-- dump date 20140620_073607 -- class Genbank::misc_feature -- table misc_feature_note -- id note 889933000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 889933000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 889933000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933000004 Walker A motif; other site 889933000005 ATP binding site [chemical binding]; other site 889933000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 889933000007 Walker B motif; other site 889933000008 arginine finger; other site 889933000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 889933000010 DnaA box-binding interface [nucleotide binding]; other site 889933000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 889933000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 889933000013 putative DNA binding surface [nucleotide binding]; other site 889933000014 dimer interface [polypeptide binding]; other site 889933000015 beta-clamp/clamp loader binding surface; other site 889933000016 beta-clamp/translesion DNA polymerase binding surface; other site 889933000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 889933000018 recF protein; Region: recf; TIGR00611 889933000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 889933000020 Walker A/P-loop; other site 889933000021 ATP binding site [chemical binding]; other site 889933000022 Q-loop/lid; other site 889933000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933000024 ABC transporter signature motif; other site 889933000025 Walker B; other site 889933000026 D-loop; other site 889933000027 H-loop/switch region; other site 889933000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 889933000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933000030 Mg2+ binding site [ion binding]; other site 889933000031 G-X-G motif; other site 889933000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 889933000033 anchoring element; other site 889933000034 dimer interface [polypeptide binding]; other site 889933000035 ATP binding site [chemical binding]; other site 889933000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 889933000037 active site 889933000038 putative metal-binding site [ion binding]; other site 889933000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 889933000040 DNA gyrase subunit A; Validated; Region: PRK05560 889933000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 889933000042 CAP-like domain; other site 889933000043 active site 889933000044 primary dimer interface [polypeptide binding]; other site 889933000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889933000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889933000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889933000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889933000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889933000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889933000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 889933000052 putative substrate binding site [chemical binding]; other site 889933000053 putative ATP binding site [chemical binding]; other site 889933000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 889933000055 active sites [active] 889933000056 tetramer interface [polypeptide binding]; other site 889933000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 889933000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 889933000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 889933000060 dimer interface [polypeptide binding]; other site 889933000061 active site 889933000062 motif 1; other site 889933000063 motif 2; other site 889933000064 motif 3; other site 889933000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 889933000066 Predicted membrane protein [Function unknown]; Region: COG4392 889933000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 889933000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 889933000069 Predicted membrane protein [Function unknown]; Region: COG4241 889933000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 889933000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 889933000072 DHH family; Region: DHH; pfam01368 889933000073 DHHA1 domain; Region: DHHA1; pfam02272 889933000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 889933000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 889933000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 889933000077 replicative DNA helicase; Region: DnaB; TIGR00665 889933000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 889933000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 889933000080 Walker A motif; other site 889933000081 ATP binding site [chemical binding]; other site 889933000082 Walker B motif; other site 889933000083 DNA binding loops [nucleotide binding] 889933000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 889933000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 889933000086 GDP-binding site [chemical binding]; other site 889933000087 ACT binding site; other site 889933000088 IMP binding site; other site 889933000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889933000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933000091 active site 889933000092 phosphorylation site [posttranslational modification] 889933000093 intermolecular recognition site; other site 889933000094 dimerization interface [polypeptide binding]; other site 889933000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889933000096 DNA binding site [nucleotide binding] 889933000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 889933000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 889933000099 dimerization interface [polypeptide binding]; other site 889933000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 889933000101 putative active site [active] 889933000102 heme pocket [chemical binding]; other site 889933000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889933000104 dimer interface [polypeptide binding]; other site 889933000105 phosphorylation site [posttranslational modification] 889933000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933000107 ATP binding site [chemical binding]; other site 889933000108 Mg2+ binding site [ion binding]; other site 889933000109 G-X-G motif; other site 889933000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 889933000111 YycH protein; Region: YycH; pfam07435 889933000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 889933000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 889933000114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 889933000115 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 889933000116 putative active site [active] 889933000117 putative metal binding site [ion binding]; other site 889933000118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 889933000119 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 889933000120 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 889933000121 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 889933000122 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 889933000123 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 889933000124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 889933000125 Integrase core domain; Region: rve; pfam00665 889933000126 potential frameshift: common BLAST hit: gi|296274673|ref|YP_003644919.1| plasmid replication protein 889933000127 Replication protein; Region: Rep_1; cl02412 889933000128 Replication protein; Region: Rep_1; pfam01446 889933000129 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 889933000130 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 889933000131 dimer interface [polypeptide binding]; other site 889933000132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889933000133 ligand binding site [chemical binding]; other site 889933000134 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cd05397 889933000135 metal binding triad [ion binding]; metal-binding site 889933000136 KNTase C-terminal domain; Region: KNTase_C; pfam07827 889933000137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 889933000138 Integrase core domain; Region: rve; pfam00665 889933000139 Protein kinase domain; Region: Pkinase; pfam00069 889933000140 Catalytic domain of Protein Kinases; Region: PKc; cd00180 889933000141 active site 889933000142 ATP binding site [chemical binding]; other site 889933000143 substrate binding site [chemical binding]; other site 889933000144 activation loop (A-loop); other site 889933000145 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 889933000146 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 889933000147 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 889933000148 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 889933000149 putative homodimer interface [polypeptide binding]; other site 889933000150 putative homotetramer interface [polypeptide binding]; other site 889933000151 putative metal binding site [ion binding]; other site 889933000152 putative homodimer-homodimer interface [polypeptide binding]; other site 889933000153 putative allosteric switch controlling residues; other site 889933000154 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 889933000155 active site residue [active] 889933000156 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 889933000157 CPxP motif; other site 889933000158 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 889933000159 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 889933000160 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 889933000161 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 889933000162 active site residue [active] 889933000163 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 889933000164 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 889933000165 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 889933000166 FMN binding site [chemical binding]; other site 889933000167 active site 889933000168 catalytic residues [active] 889933000169 substrate binding site [chemical binding]; other site 889933000170 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 889933000171 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 889933000172 Part of AAA domain; Region: AAA_19; pfam13245 889933000173 AAA domain; Region: AAA_12; pfam13087 889933000174 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 889933000175 active site 889933000176 catalytic site [active] 889933000177 putative metal binding site [ion binding]; other site 889933000178 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933000179 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933000180 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933000181 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933000182 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933000183 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 889933000184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889933000185 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 889933000186 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 889933000187 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 889933000188 metal binding site [ion binding]; metal-binding site 889933000189 dimer interface [polypeptide binding]; other site 889933000190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933000191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889933000192 putative substrate translocation pore; other site 889933000193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933000194 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 889933000195 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 889933000196 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 889933000197 PhoU domain; Region: PhoU; pfam01895 889933000198 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 889933000199 EamA-like transporter family; Region: EamA; pfam00892 889933000200 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 889933000201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889933000202 DNA-binding site [nucleotide binding]; DNA binding site 889933000203 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889933000204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933000205 homodimer interface [polypeptide binding]; other site 889933000206 catalytic residue [active] 889933000207 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 889933000208 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 889933000209 L-lactate permease; Region: Lactate_perm; cl00701 889933000210 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933000211 B domain; Region: B; pfam02216 889933000212 B domain; Region: B; pfam02216 889933000213 B domain; Region: B; pfam02216 889933000214 B domain; Region: B; pfam02216 889933000215 B domain; Region: B; pfam02216 889933000216 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 889933000217 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933000218 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889933000219 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933000220 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889933000221 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 889933000222 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933000223 ABC-ATPase subunit interface; other site 889933000224 dimer interface [polypeptide binding]; other site 889933000225 putative PBP binding regions; other site 889933000226 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 889933000227 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933000228 ABC-ATPase subunit interface; other site 889933000229 dimer interface [polypeptide binding]; other site 889933000230 putative PBP binding regions; other site 889933000231 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 889933000232 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 889933000233 siderophore binding site; other site 889933000234 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 889933000235 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 889933000236 dimer interface [polypeptide binding]; other site 889933000237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933000238 catalytic residue [active] 889933000239 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 889933000240 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 889933000241 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 889933000242 IucA / IucC family; Region: IucA_IucC; pfam04183 889933000243 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 889933000244 drug efflux system protein MdtG; Provisional; Region: PRK09874 889933000245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933000246 putative substrate translocation pore; other site 889933000247 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 889933000248 IucA / IucC family; Region: IucA_IucC; pfam04183 889933000249 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 889933000250 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 889933000251 IucA / IucC family; Region: IucA_IucC; pfam04183 889933000252 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 889933000253 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 889933000254 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 889933000255 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 889933000256 dimer interface [polypeptide binding]; other site 889933000257 active site 889933000258 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889933000259 catalytic residues [active] 889933000260 substrate binding site [chemical binding]; other site 889933000261 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 889933000262 ParB-like nuclease domain; Region: ParBc; pfam02195 889933000263 acetoin reductase; Validated; Region: PRK08643 889933000264 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 889933000265 NAD binding site [chemical binding]; other site 889933000266 homotetramer interface [polypeptide binding]; other site 889933000267 homodimer interface [polypeptide binding]; other site 889933000268 active site 889933000269 substrate binding site [chemical binding]; other site 889933000270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889933000271 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 889933000272 NAD(P) binding site [chemical binding]; other site 889933000273 active site 889933000274 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 889933000275 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 889933000276 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889933000277 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 889933000278 putative ADP-binding pocket [chemical binding]; other site 889933000279 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 889933000280 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 889933000281 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 889933000282 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 889933000283 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 889933000284 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889933000285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889933000286 DNA-binding site [nucleotide binding]; DNA binding site 889933000287 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 889933000288 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 889933000289 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889933000290 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 889933000291 intersubunit interface [polypeptide binding]; other site 889933000292 active site 889933000293 catalytic residue [active] 889933000294 phosphopentomutase; Provisional; Region: PRK05362 889933000295 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 889933000296 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 889933000297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933000298 dimer interface [polypeptide binding]; other site 889933000299 conserved gate region; other site 889933000300 putative PBP binding loops; other site 889933000301 ABC-ATPase subunit interface; other site 889933000302 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 889933000303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933000304 dimer interface [polypeptide binding]; other site 889933000305 conserved gate region; other site 889933000306 ABC-ATPase subunit interface; other site 889933000307 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 889933000308 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 889933000309 Walker A/P-loop; other site 889933000310 ATP binding site [chemical binding]; other site 889933000311 Q-loop/lid; other site 889933000312 ABC transporter signature motif; other site 889933000313 Walker B; other site 889933000314 D-loop; other site 889933000315 H-loop/switch region; other site 889933000316 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 889933000317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 889933000318 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 889933000319 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 889933000320 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 889933000321 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 889933000322 active site 889933000323 metal binding site [ion binding]; metal-binding site 889933000324 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 889933000325 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 889933000326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889933000327 non-specific DNA binding site [nucleotide binding]; other site 889933000328 salt bridge; other site 889933000329 sequence-specific DNA binding site [nucleotide binding]; other site 889933000330 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 889933000331 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 889933000332 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 889933000333 putative catalytic cysteine [active] 889933000334 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 889933000335 putative active site [active] 889933000336 metal binding site [ion binding]; metal-binding site 889933000337 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 889933000338 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 889933000339 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 889933000340 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 889933000341 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 889933000342 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 889933000343 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 889933000344 NAD(P) binding site [chemical binding]; other site 889933000345 homodimer interface [polypeptide binding]; other site 889933000346 substrate binding site [chemical binding]; other site 889933000347 active site 889933000348 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 889933000349 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 889933000350 NAD(P) binding site [chemical binding]; other site 889933000351 homodimer interface [polypeptide binding]; other site 889933000352 substrate binding site [chemical binding]; other site 889933000353 active site 889933000354 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 889933000355 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 889933000356 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 889933000357 putative NAD(P) binding site [chemical binding]; other site 889933000358 active site 889933000359 putative substrate binding site [chemical binding]; other site 889933000360 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 889933000361 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 889933000362 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 889933000363 active site 889933000364 homodimer interface [polypeptide binding]; other site 889933000365 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 889933000366 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 889933000367 trimer interface [polypeptide binding]; other site 889933000368 active site 889933000369 substrate binding site [chemical binding]; other site 889933000370 CoA binding site [chemical binding]; other site 889933000371 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889933000372 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 889933000373 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 889933000374 O-Antigen ligase; Region: Wzy_C; pfam04932 889933000375 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 889933000376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889933000377 Bacterial sugar transferase; Region: Bac_transf; pfam02397 889933000378 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 889933000379 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 889933000380 putative NAD(P) binding site [chemical binding]; other site 889933000381 active site 889933000382 putative substrate binding site [chemical binding]; other site 889933000383 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 889933000384 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 889933000385 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 889933000386 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 889933000387 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 889933000388 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 889933000389 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 889933000390 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 889933000391 Int/Topo IB signature motif; other site 889933000392 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 889933000393 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 889933000394 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 889933000395 Int/Topo IB signature motif; other site 889933000396 aminoglycoside resistance protein; Provisional; Region: PRK13746 889933000397 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 889933000398 active site 889933000399 NTP binding site [chemical binding]; other site 889933000400 metal binding triad [ion binding]; metal-binding site 889933000401 antibiotic binding site [chemical binding]; other site 889933000402 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 889933000403 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 889933000404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933000405 S-adenosylmethionine binding site [chemical binding]; other site 889933000406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933000407 S-adenosylmethionine binding site [chemical binding]; other site 889933000408 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 889933000409 active site 889933000410 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 889933000411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 889933000412 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 889933000413 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 889933000414 NAD(P) binding site [chemical binding]; other site 889933000415 catalytic residues [active] 889933000416 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 889933000417 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 889933000418 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 889933000419 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 889933000420 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 889933000421 Walker A/P-loop; other site 889933000422 ATP binding site [chemical binding]; other site 889933000423 Q-loop/lid; other site 889933000424 ABC transporter signature motif; other site 889933000425 Walker B; other site 889933000426 D-loop; other site 889933000427 H-loop/switch region; other site 889933000428 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 889933000429 NMT1-like family; Region: NMT1_2; pfam13379 889933000430 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 889933000431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 889933000432 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 889933000433 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 889933000434 active site 889933000435 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 889933000436 formate dehydrogenase; Provisional; Region: PRK07574 889933000437 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 889933000438 dimerization interface [polypeptide binding]; other site 889933000439 ligand binding site [chemical binding]; other site 889933000440 NAD binding site [chemical binding]; other site 889933000441 catalytic site [active] 889933000442 putative transporter; Provisional; Region: PRK10054 889933000443 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 889933000444 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 889933000445 acyl-activating enzyme (AAE) consensus motif; other site 889933000446 AMP binding site [chemical binding]; other site 889933000447 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 889933000448 Condensation domain; Region: Condensation; pfam00668 889933000449 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 889933000450 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 889933000451 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 889933000452 acyl-activating enzyme (AAE) consensus motif; other site 889933000453 AMP binding site [chemical binding]; other site 889933000454 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 889933000455 thioester reductase domain; Region: Thioester-redct; TIGR01746 889933000456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889933000457 NAD(P) binding site [chemical binding]; other site 889933000458 active site 889933000459 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 889933000460 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 889933000461 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 889933000462 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 889933000463 nucleotide binding site [chemical binding]; other site 889933000464 N-acetyl-L-glutamate binding site [chemical binding]; other site 889933000465 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 889933000466 heterotetramer interface [polypeptide binding]; other site 889933000467 active site pocket [active] 889933000468 cleavage site 889933000469 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 889933000470 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 889933000471 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 889933000472 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889933000473 inhibitor-cofactor binding pocket; inhibition site 889933000474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933000475 catalytic residue [active] 889933000476 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 889933000477 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 889933000478 Isochorismatase family; Region: Isochorismatase; pfam00857 889933000479 catalytic triad [active] 889933000480 conserved cis-peptide bond; other site 889933000481 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 889933000482 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 889933000483 dimer interface [polypeptide binding]; other site 889933000484 PYR/PP interface [polypeptide binding]; other site 889933000485 TPP binding site [chemical binding]; other site 889933000486 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 889933000487 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 889933000488 TPP-binding site [chemical binding]; other site 889933000489 dimer interface [polypeptide binding]; other site 889933000490 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 889933000491 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 889933000492 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889933000493 active site turn [active] 889933000494 phosphorylation site [posttranslational modification] 889933000495 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 889933000496 HPr interaction site; other site 889933000497 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889933000498 active site 889933000499 phosphorylation site [posttranslational modification] 889933000500 Uncharacterized conserved protein [Function unknown]; Region: COG3589 889933000501 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 889933000502 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 889933000503 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 889933000504 putative active site [active] 889933000505 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 889933000506 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889933000507 active site turn [active] 889933000508 phosphorylation site [posttranslational modification] 889933000509 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 889933000510 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 889933000511 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 889933000512 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 889933000513 putative active site [active] 889933000514 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 889933000515 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 889933000516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889933000517 ATP binding site [chemical binding]; other site 889933000518 putative Mg++ binding site [ion binding]; other site 889933000519 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 889933000520 HlyD family secretion protein; Region: HlyD_3; pfam13437 889933000521 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889933000522 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 889933000523 Walker A/P-loop; other site 889933000524 ATP binding site [chemical binding]; other site 889933000525 Q-loop/lid; other site 889933000526 ABC transporter signature motif; other site 889933000527 Walker B; other site 889933000528 D-loop; other site 889933000529 H-loop/switch region; other site 889933000530 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889933000531 FtsX-like permease family; Region: FtsX; pfam02687 889933000532 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 889933000533 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889933000534 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 889933000535 Walker A/P-loop; other site 889933000536 ATP binding site [chemical binding]; other site 889933000537 Q-loop/lid; other site 889933000538 ABC transporter signature motif; other site 889933000539 Walker B; other site 889933000540 D-loop; other site 889933000541 H-loop/switch region; other site 889933000542 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 889933000543 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 889933000544 Walker A/P-loop; other site 889933000545 ATP binding site [chemical binding]; other site 889933000546 Q-loop/lid; other site 889933000547 ABC transporter signature motif; other site 889933000548 Walker B; other site 889933000549 D-loop; other site 889933000550 H-loop/switch region; other site 889933000551 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 889933000552 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 889933000553 Walker A/P-loop; other site 889933000554 ATP binding site [chemical binding]; other site 889933000555 Q-loop/lid; other site 889933000556 ABC transporter signature motif; other site 889933000557 Walker B; other site 889933000558 D-loop; other site 889933000559 H-loop/switch region; other site 889933000560 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889933000561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933000562 dimer interface [polypeptide binding]; other site 889933000563 conserved gate region; other site 889933000564 putative PBP binding loops; other site 889933000565 ABC-ATPase subunit interface; other site 889933000566 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 889933000567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933000568 dimer interface [polypeptide binding]; other site 889933000569 conserved gate region; other site 889933000570 ABC-ATPase subunit interface; other site 889933000571 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 889933000572 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 889933000573 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 889933000574 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 889933000575 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 889933000576 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 889933000577 azoreductase; Reviewed; Region: PRK00170 889933000578 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 889933000579 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 889933000580 Peptidase family M23; Region: Peptidase_M23; pfam01551 889933000581 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 889933000582 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 889933000583 Walker A/P-loop; other site 889933000584 ATP binding site [chemical binding]; other site 889933000585 Q-loop/lid; other site 889933000586 ABC transporter signature motif; other site 889933000587 Walker B; other site 889933000588 D-loop; other site 889933000589 H-loop/switch region; other site 889933000590 TOBE domain; Region: TOBE; pfam03459 889933000591 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 889933000592 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 889933000593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933000594 dimer interface [polypeptide binding]; other site 889933000595 conserved gate region; other site 889933000596 ABC-ATPase subunit interface; other site 889933000597 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 889933000598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933000599 dimer interface [polypeptide binding]; other site 889933000600 conserved gate region; other site 889933000601 putative PBP binding loops; other site 889933000602 ABC-ATPase subunit interface; other site 889933000603 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 889933000604 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 889933000605 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 889933000606 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 889933000607 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 889933000608 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 889933000609 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 889933000610 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 889933000611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 889933000612 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 889933000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933000614 putative substrate translocation pore; other site 889933000615 Response regulator receiver domain; Region: Response_reg; pfam00072 889933000616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933000617 active site 889933000618 phosphorylation site [posttranslational modification] 889933000619 intermolecular recognition site; other site 889933000620 dimerization interface [polypeptide binding]; other site 889933000621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889933000622 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 889933000623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889933000624 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 889933000625 Histidine kinase; Region: His_kinase; pfam06580 889933000626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933000627 ATP binding site [chemical binding]; other site 889933000628 Mg2+ binding site [ion binding]; other site 889933000629 G-X-G motif; other site 889933000630 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 889933000631 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 889933000632 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 889933000633 Pyruvate formate lyase 1; Region: PFL1; cd01678 889933000634 coenzyme A binding site [chemical binding]; other site 889933000635 active site 889933000636 catalytic residues [active] 889933000637 glycine loop; other site 889933000638 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 889933000639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889933000640 FeS/SAM binding site; other site 889933000641 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 889933000642 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 889933000643 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 889933000644 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 889933000645 putative active site [active] 889933000646 catalytic site [active] 889933000647 putative metal binding site [ion binding]; other site 889933000648 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 889933000649 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 889933000650 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 889933000651 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 889933000652 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 889933000653 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 889933000654 dimer interface [polypeptide binding]; other site 889933000655 active site 889933000656 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 889933000657 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 889933000658 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 889933000659 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 889933000660 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 889933000661 substrate binding site [chemical binding]; other site 889933000662 oxyanion hole (OAH) forming residues; other site 889933000663 trimer interface [polypeptide binding]; other site 889933000664 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 889933000665 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 889933000666 active site 889933000667 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 889933000668 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 889933000669 acyl-activating enzyme (AAE) consensus motif; other site 889933000670 AMP binding site [chemical binding]; other site 889933000671 active site 889933000672 CoA binding site [chemical binding]; other site 889933000673 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 889933000674 Coenzyme A transferase; Region: CoA_trans; smart00882 889933000675 Coenzyme A transferase; Region: CoA_trans; cl17247 889933000676 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 889933000677 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 889933000678 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 889933000679 Uncharacterized conserved protein [Function unknown]; Region: COG3189 889933000680 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 889933000681 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 889933000682 heme-binding site [chemical binding]; other site 889933000683 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 889933000684 FAD binding pocket [chemical binding]; other site 889933000685 FAD binding motif [chemical binding]; other site 889933000686 phosphate binding motif [ion binding]; other site 889933000687 beta-alpha-beta structure motif; other site 889933000688 NAD binding pocket [chemical binding]; other site 889933000689 Heme binding pocket [chemical binding]; other site 889933000690 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 889933000691 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 889933000692 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889933000693 NAD binding site [chemical binding]; other site 889933000694 dimer interface [polypeptide binding]; other site 889933000695 substrate binding site [chemical binding]; other site 889933000696 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 889933000697 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 889933000698 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889933000699 active site turn [active] 889933000700 phosphorylation site [posttranslational modification] 889933000701 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 889933000702 active site 889933000703 tetramer interface [polypeptide binding]; other site 889933000704 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 889933000705 Mga helix-turn-helix domain; Region: Mga; pfam05043 889933000706 PRD domain; Region: PRD; pfam00874 889933000707 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 889933000708 active site 889933000709 P-loop; other site 889933000710 phosphorylation site [posttranslational modification] 889933000711 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889933000712 active site 889933000713 phosphorylation site [posttranslational modification] 889933000714 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889933000715 active site 889933000716 phosphorylation site [posttranslational modification] 889933000717 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 889933000718 active site 889933000719 P-loop; other site 889933000720 phosphorylation site [posttranslational modification] 889933000721 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 889933000722 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 889933000723 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 889933000724 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 889933000725 putative NAD(P) binding site [chemical binding]; other site 889933000726 catalytic Zn binding site [ion binding]; other site 889933000727 structural Zn binding site [ion binding]; other site 889933000728 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 889933000729 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 889933000730 putative NAD(P) binding site [chemical binding]; other site 889933000731 catalytic Zn binding site [ion binding]; other site 889933000732 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 889933000733 substrate binding site; other site 889933000734 dimer interface; other site 889933000735 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 889933000736 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 889933000737 putative NAD(P) binding site [chemical binding]; other site 889933000738 putative catalytic Zn binding site [ion binding]; other site 889933000739 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 889933000740 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 889933000741 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 889933000742 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 889933000743 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 889933000744 substrate binding site; other site 889933000745 dimer interface; other site 889933000746 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 889933000747 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 889933000748 putative NAD(P) binding site [chemical binding]; other site 889933000749 putative catalytic Zn binding site [ion binding]; other site 889933000750 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 889933000751 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 889933000752 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 889933000753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 889933000754 active site 889933000755 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 889933000756 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 889933000757 Hemerythrin-like domain; Region: Hr-like; cd12108 889933000758 Fe binding site [ion binding]; other site 889933000759 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 889933000760 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 889933000761 Histidine kinase; Region: His_kinase; pfam06580 889933000762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933000763 Mg2+ binding site [ion binding]; other site 889933000764 G-X-G motif; other site 889933000765 two-component response regulator; Provisional; Region: PRK14084 889933000766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933000767 active site 889933000768 phosphorylation site [posttranslational modification] 889933000769 intermolecular recognition site; other site 889933000770 dimerization interface [polypeptide binding]; other site 889933000771 LytTr DNA-binding domain; Region: LytTR; pfam04397 889933000772 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 889933000773 antiholin-like protein LrgB; Provisional; Region: PRK04288 889933000774 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889933000775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889933000776 DNA-binding site [nucleotide binding]; DNA binding site 889933000777 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 889933000778 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 889933000779 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 889933000780 HPr interaction site; other site 889933000781 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889933000782 active site 889933000783 phosphorylation site [posttranslational modification] 889933000784 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889933000785 beta-galactosidase; Region: BGL; TIGR03356 889933000786 Methyltransferase domain; Region: Methyltransf_31; pfam13847 889933000787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933000788 S-adenosylmethionine binding site [chemical binding]; other site 889933000789 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 889933000790 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 889933000791 substrate binding site [chemical binding]; other site 889933000792 dimer interface [polypeptide binding]; other site 889933000793 ATP binding site [chemical binding]; other site 889933000794 D-ribose pyranase; Provisional; Region: PRK11797 889933000795 Sugar transport protein; Region: Sugar_transport; pfam06800 889933000796 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889933000797 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889933000798 DNA binding site [nucleotide binding] 889933000799 domain linker motif; other site 889933000800 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 889933000801 dimerization interface [polypeptide binding]; other site 889933000802 ligand binding site [chemical binding]; other site 889933000803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933000804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933000805 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 889933000806 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 889933000807 active site 889933000808 Surface antigen [General function prediction only]; Region: COG3942 889933000809 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 889933000810 Peptidase family M23; Region: Peptidase_M23; pfam01551 889933000811 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 889933000812 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 889933000813 Walker A/P-loop; other site 889933000814 ATP binding site [chemical binding]; other site 889933000815 Q-loop/lid; other site 889933000816 ABC transporter signature motif; other site 889933000817 Walker B; other site 889933000818 D-loop; other site 889933000819 H-loop/switch region; other site 889933000820 Surface antigen [General function prediction only]; Region: COG3942 889933000821 CHAP domain; Region: CHAP; pfam05257 889933000822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 889933000823 Predicted membrane protein [Function unknown]; Region: COG1511 889933000824 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 889933000825 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 889933000826 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 889933000827 Uncharacterized small protein [Function unknown]; Region: COG5417 889933000828 Predicted membrane protein [Function unknown]; Region: COG4499 889933000829 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 889933000830 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 889933000831 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 889933000832 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 889933000833 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 889933000834 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 889933000835 Uncharacterized conserved protein [Function unknown]; Region: COG5444 889933000836 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 889933000837 Protein of unknown function, DUF600; Region: DUF600; cl04640 889933000838 Protein of unknown function, DUF600; Region: DUF600; cl04640 889933000839 Protein of unknown function, DUF600; Region: DUF600; cl04640 889933000840 Protein of unknown function, DUF600; Region: DUF600; cl04640 889933000841 Protein of unknown function, DUF600; Region: DUF600; cl04640 889933000842 Protein of unknown function, DUF600; Region: DUF600; cl04640 889933000843 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 889933000844 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 889933000845 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 889933000846 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 889933000847 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889933000848 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 889933000849 FtsX-like permease family; Region: FtsX; pfam02687 889933000850 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889933000851 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 889933000852 Walker A/P-loop; other site 889933000853 ATP binding site [chemical binding]; other site 889933000854 Q-loop/lid; other site 889933000855 ABC transporter signature motif; other site 889933000856 Walker B; other site 889933000857 D-loop; other site 889933000858 H-loop/switch region; other site 889933000859 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 889933000860 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 889933000861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889933000862 non-specific DNA binding site [nucleotide binding]; other site 889933000863 salt bridge; other site 889933000864 sequence-specific DNA binding site [nucleotide binding]; other site 889933000865 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 889933000866 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 889933000867 substrate binding site [chemical binding]; other site 889933000868 ATP binding site [chemical binding]; other site 889933000869 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 889933000870 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 889933000871 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 889933000872 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 889933000873 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 889933000874 putative transporter; Provisional; Region: PRK10484 889933000875 Na binding site [ion binding]; other site 889933000876 N-acetylneuraminate lyase; Provisional; Region: PRK04147 889933000877 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 889933000878 inhibitor site; inhibition site 889933000879 active site 889933000880 dimer interface [polypeptide binding]; other site 889933000881 catalytic residue [active] 889933000882 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889933000883 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 889933000884 nucleotide binding site [chemical binding]; other site 889933000885 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 889933000886 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 889933000887 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 889933000888 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 889933000889 putative active site [active] 889933000890 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 889933000891 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 889933000892 putative active site cavity [active] 889933000893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 889933000894 Nucleoside recognition; Region: Gate; pfam07670 889933000895 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 889933000896 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 889933000897 PGAP1-like protein; Region: PGAP1; pfam07819 889933000898 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 889933000899 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 889933000900 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 889933000901 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 889933000902 putative active site [active] 889933000903 putative FMN binding site [chemical binding]; other site 889933000904 putative substrate binding site [chemical binding]; other site 889933000905 putative catalytic residue [active] 889933000906 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 889933000907 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 889933000908 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 889933000909 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 889933000910 lipoyl attachment site [posttranslational modification]; other site 889933000911 Replication protein C N-terminal domain; Region: RP-C; pfam03428 889933000912 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 889933000913 putative ADP-ribose binding site [chemical binding]; other site 889933000914 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 889933000915 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 889933000916 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 889933000917 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 889933000918 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 889933000919 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 889933000920 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 889933000921 NADP binding site [chemical binding]; other site 889933000922 putative substrate binding site [chemical binding]; other site 889933000923 active site 889933000924 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 889933000925 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 889933000926 active site 889933000927 P-loop; other site 889933000928 phosphorylation site [posttranslational modification] 889933000929 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889933000930 active site 889933000931 phosphorylation site [posttranslational modification] 889933000932 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 889933000933 HTH domain; Region: HTH_11; pfam08279 889933000934 HTH domain; Region: HTH_11; pfam08279 889933000935 PRD domain; Region: PRD; pfam00874 889933000936 PRD domain; Region: PRD; pfam00874 889933000937 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 889933000938 active site 889933000939 P-loop; other site 889933000940 phosphorylation site [posttranslational modification] 889933000941 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889933000942 active site 889933000943 phosphorylation site [posttranslational modification] 889933000944 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889933000945 MarR family; Region: MarR_2; pfam12802 889933000946 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 889933000947 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 889933000948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 889933000949 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 889933000950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933000951 putative substrate translocation pore; other site 889933000952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933000953 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 889933000954 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889933000955 Zn binding site [ion binding]; other site 889933000956 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 889933000957 Zn binding site [ion binding]; other site 889933000958 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 889933000959 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 889933000960 Predicted flavoprotein [General function prediction only]; Region: COG0431 889933000961 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 889933000962 Predicted membrane protein [Function unknown]; Region: COG2855 889933000963 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 889933000964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 889933000965 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 889933000966 Imelysin; Region: Peptidase_M75; pfam09375 889933000967 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 889933000968 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 889933000969 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 889933000970 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 889933000971 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 889933000972 Phage envelope protein [General function prediction only]; Region: COG5562 889933000973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889933000974 non-specific DNA binding site [nucleotide binding]; other site 889933000975 salt bridge; other site 889933000976 sequence-specific DNA binding site [nucleotide binding]; other site 889933000977 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 889933000978 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889933000979 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 889933000980 Walker A/P-loop; other site 889933000981 ATP binding site [chemical binding]; other site 889933000982 Q-loop/lid; other site 889933000983 ABC transporter signature motif; other site 889933000984 Walker B; other site 889933000985 D-loop; other site 889933000986 H-loop/switch region; other site 889933000987 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 889933000988 Predicted membrane protein [Function unknown]; Region: COG4292 889933000989 putative acyltransferase; Provisional; Region: PRK05790 889933000990 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 889933000991 dimer interface [polypeptide binding]; other site 889933000992 active site 889933000993 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 889933000994 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 889933000995 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 889933000996 THF binding site; other site 889933000997 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 889933000998 substrate binding site [chemical binding]; other site 889933000999 THF binding site; other site 889933001000 zinc-binding site [ion binding]; other site 889933001001 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 889933001002 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 889933001003 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 889933001004 FAD binding site [chemical binding]; other site 889933001005 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 889933001006 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 889933001007 homodimer interface [polypeptide binding]; other site 889933001008 substrate-cofactor binding pocket; other site 889933001009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933001010 catalytic residue [active] 889933001011 cystathionine gamma-synthase; Reviewed; Region: PRK08247 889933001012 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889933001013 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889933001014 catalytic residue [active] 889933001015 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 889933001016 ParB-like nuclease domain; Region: ParB; smart00470 889933001017 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 889933001018 Mechanosensitive ion channel; Region: MS_channel; pfam00924 889933001019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 889933001020 GTP-binding protein YchF; Reviewed; Region: PRK09601 889933001021 YchF GTPase; Region: YchF; cd01900 889933001022 G1 box; other site 889933001023 GTP/Mg2+ binding site [chemical binding]; other site 889933001024 Switch I region; other site 889933001025 G2 box; other site 889933001026 Switch II region; other site 889933001027 G3 box; other site 889933001028 G4 box; other site 889933001029 G5 box; other site 889933001030 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 889933001031 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 889933001032 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 889933001033 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 889933001034 dimer interface [polypeptide binding]; other site 889933001035 ssDNA binding site [nucleotide binding]; other site 889933001036 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889933001037 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 889933001038 Abi-like protein; Region: Abi_2; pfam07751 889933001039 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 889933001040 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 889933001042 Predicted membrane protein [Function unknown]; Region: COG3212 889933001043 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 889933001044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 889933001045 non-specific DNA binding site [nucleotide binding]; other site 889933001046 salt bridge; other site 889933001047 sequence-specific DNA binding site [nucleotide binding]; other site 889933001048 Predicted membrane protein [Function unknown]; Region: COG2261 889933001049 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889933001050 catalytic core [active] 889933001051 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 889933001052 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 889933001053 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 889933001054 catalytic residue [active] 889933001055 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 889933001056 catalytic residues [active] 889933001057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 889933001058 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933001059 peroxiredoxin; Region: AhpC; TIGR03137 889933001060 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 889933001061 dimer interface [polypeptide binding]; other site 889933001062 decamer (pentamer of dimers) interface [polypeptide binding]; other site 889933001063 catalytic triad [active] 889933001064 peroxidatic and resolving cysteines [active] 889933001065 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 889933001066 dimer interface [polypeptide binding]; other site 889933001067 FMN binding site [chemical binding]; other site 889933001068 NADPH bind site [chemical binding]; other site 889933001069 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 889933001070 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 889933001071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889933001072 active site 889933001073 xanthine permease; Region: pbuX; TIGR03173 889933001074 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 889933001075 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 889933001076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 889933001077 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 889933001078 active site 889933001079 GMP synthase; Reviewed; Region: guaA; PRK00074 889933001080 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 889933001081 AMP/PPi binding site [chemical binding]; other site 889933001082 candidate oxyanion hole; other site 889933001083 catalytic triad [active] 889933001084 potential glutamine specificity residues [chemical binding]; other site 889933001085 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 889933001086 ATP Binding subdomain [chemical binding]; other site 889933001087 Ligand Binding sites [chemical binding]; other site 889933001088 Dimerization subdomain; other site 889933001089 PemK-like protein; Region: PemK; pfam02452 889933001090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 889933001091 Transposase; Region: HTH_Tnp_1; cl17663 889933001092 Predicted membrane protein [Function unknown]; Region: COG3759 889933001093 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 889933001094 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 889933001095 NADP binding site [chemical binding]; other site 889933001096 superantigen-like protein; Reviewed; Region: PRK13037 889933001097 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 889933001098 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001099 superantigen-like protein; Reviewed; Region: PRK13041 889933001100 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 889933001101 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001102 superantigen-like protein; Reviewed; Region: PRK13335 889933001103 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 889933001104 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001105 superantigen-like protein; Reviewed; Region: PRK13042 889933001106 Mucin-like glycoprotein; Region: Mucin; pfam01456 889933001107 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 889933001108 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001109 superantigen-like protein 5; Reviewed; Region: PRK13035 889933001110 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 889933001111 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001112 superantigen-like protein 7; Reviewed; Region: PRK13346 889933001113 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 889933001114 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001115 superantigen-like protein; Reviewed; Region: PRK13039 889933001116 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 889933001117 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001118 superantigen-like protein; Reviewed; Region: PRK13345 889933001119 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 889933001120 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001121 superantigen-like protein 5; Reviewed; Region: PRK13035 889933001122 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 889933001123 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001124 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 889933001125 HsdM N-terminal domain; Region: HsdM_N; pfam12161 889933001126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933001127 S-adenosylmethionine binding site [chemical binding]; other site 889933001128 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 889933001129 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 889933001130 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 889933001131 superantigen-like protein; Reviewed; Region: PRK13036 889933001132 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 889933001133 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933001134 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933001135 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933001136 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933001137 Protein of unknown function, DUF576; Region: DUF576; cl04553 889933001138 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933001139 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933001140 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933001141 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933001142 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933001143 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933001144 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 889933001145 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 889933001146 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 889933001147 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 889933001148 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 889933001149 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 889933001150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 889933001151 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 889933001152 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 889933001153 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 889933001154 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 889933001155 active site 889933001156 Esterase/lipase [General function prediction only]; Region: COG1647 889933001157 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 889933001158 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 889933001159 Na2 binding site [ion binding]; other site 889933001160 putative substrate binding site 1 [chemical binding]; other site 889933001161 Na binding site 1 [ion binding]; other site 889933001162 putative substrate binding site 2 [chemical binding]; other site 889933001163 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 889933001164 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 889933001165 dimer interface [polypeptide binding]; other site 889933001166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933001167 catalytic residue [active] 889933001168 cystathionine beta-lyase; Provisional; Region: PRK07671 889933001169 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 889933001170 homodimer interface [polypeptide binding]; other site 889933001171 substrate-cofactor binding pocket; other site 889933001172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933001173 catalytic residue [active] 889933001174 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 889933001175 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 889933001176 Walker A/P-loop; other site 889933001177 ATP binding site [chemical binding]; other site 889933001178 Q-loop/lid; other site 889933001179 ABC transporter signature motif; other site 889933001180 Walker B; other site 889933001181 D-loop; other site 889933001182 H-loop/switch region; other site 889933001183 NIL domain; Region: NIL; pfam09383 889933001184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933001185 dimer interface [polypeptide binding]; other site 889933001186 conserved gate region; other site 889933001187 ABC-ATPase subunit interface; other site 889933001188 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 889933001189 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 889933001190 LysM domain; Region: LysM; pfam01476 889933001191 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 889933001192 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 889933001193 Surface antigen [General function prediction only]; Region: COG3942 889933001194 CHAP domain; Region: CHAP; pfam05257 889933001195 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 889933001196 nudix motif; other site 889933001197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933001198 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 889933001199 Coenzyme A binding pocket [chemical binding]; other site 889933001200 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 889933001201 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 889933001202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889933001203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 889933001204 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889933001205 dimerization interface [polypeptide binding]; other site 889933001206 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 889933001207 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 889933001208 active site 889933001209 dimer interface [polypeptide binding]; other site 889933001210 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 889933001211 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 889933001212 active site 889933001213 FMN binding site [chemical binding]; other site 889933001214 substrate binding site [chemical binding]; other site 889933001215 3Fe-4S cluster binding site [ion binding]; other site 889933001216 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 889933001217 domain interface; other site 889933001218 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 889933001219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 889933001220 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 889933001221 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889933001222 active site turn [active] 889933001223 phosphorylation site [posttranslational modification] 889933001224 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 889933001225 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 889933001226 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 889933001227 Ca binding site [ion binding]; other site 889933001228 active site 889933001229 catalytic site [active] 889933001230 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 889933001231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889933001232 DNA-binding site [nucleotide binding]; DNA binding site 889933001233 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 889933001234 UTRA domain; Region: UTRA; pfam07702 889933001235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889933001236 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889933001237 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 889933001238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933001239 Coenzyme A binding pocket [chemical binding]; other site 889933001240 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 889933001241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933001242 Walker A motif; other site 889933001243 ATP binding site [chemical binding]; other site 889933001244 Walker B motif; other site 889933001245 arginine finger; other site 889933001246 hypothetical protein; Validated; Region: PRK00153 889933001247 recombination protein RecR; Reviewed; Region: recR; PRK00076 889933001248 RecR protein; Region: RecR; pfam02132 889933001249 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 889933001250 putative active site [active] 889933001251 putative metal-binding site [ion binding]; other site 889933001252 tetramer interface [polypeptide binding]; other site 889933001253 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 889933001254 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889933001255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889933001256 catalytic residue [active] 889933001257 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 889933001258 thymidylate kinase; Validated; Region: tmk; PRK00698 889933001259 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 889933001260 TMP-binding site; other site 889933001261 ATP-binding site [chemical binding]; other site 889933001262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 889933001263 DNA polymerase III subunit delta'; Validated; Region: PRK08058 889933001264 DNA polymerase III subunit delta'; Validated; Region: PRK08485 889933001265 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 889933001266 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 889933001267 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 889933001268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933001269 S-adenosylmethionine binding site [chemical binding]; other site 889933001270 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 889933001271 GIY-YIG motif/motif A; other site 889933001272 putative active site [active] 889933001273 putative metal binding site [ion binding]; other site 889933001274 Predicted methyltransferases [General function prediction only]; Region: COG0313 889933001275 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 889933001276 putative SAM binding site [chemical binding]; other site 889933001277 putative homodimer interface [polypeptide binding]; other site 889933001278 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 889933001279 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 889933001280 active site 889933001281 HIGH motif; other site 889933001282 KMSKS motif; other site 889933001283 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 889933001284 tRNA binding surface [nucleotide binding]; other site 889933001285 anticodon binding site; other site 889933001286 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 889933001287 dimer interface [polypeptide binding]; other site 889933001288 putative tRNA-binding site [nucleotide binding]; other site 889933001289 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 889933001290 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 889933001291 active site 889933001292 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 889933001293 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 889933001294 putative active site [active] 889933001295 putative metal binding site [ion binding]; other site 889933001296 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 889933001297 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 889933001298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933001299 S-adenosylmethionine binding site [chemical binding]; other site 889933001300 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 889933001301 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 889933001302 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 889933001303 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 889933001304 pur operon repressor; Provisional; Region: PRK09213 889933001305 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 889933001306 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889933001307 active site 889933001308 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 889933001309 homotrimer interaction site [polypeptide binding]; other site 889933001310 putative active site [active] 889933001311 regulatory protein SpoVG; Reviewed; Region: PRK13259 889933001312 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 889933001313 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 889933001314 Substrate binding site; other site 889933001315 Mg++ binding site; other site 889933001316 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 889933001317 active site 889933001318 substrate binding site [chemical binding]; other site 889933001319 CoA binding site [chemical binding]; other site 889933001320 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 889933001321 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 889933001322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889933001323 active site 889933001324 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 889933001325 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 889933001326 5S rRNA interface [nucleotide binding]; other site 889933001327 CTC domain interface [polypeptide binding]; other site 889933001328 L16 interface [polypeptide binding]; other site 889933001329 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 889933001330 putative active site [active] 889933001331 catalytic residue [active] 889933001332 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 889933001333 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 889933001334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889933001335 ATP binding site [chemical binding]; other site 889933001336 putative Mg++ binding site [ion binding]; other site 889933001337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889933001338 nucleotide binding region [chemical binding]; other site 889933001339 ATP-binding site [chemical binding]; other site 889933001340 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 889933001341 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 889933001342 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 889933001343 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 889933001344 putative SAM binding site [chemical binding]; other site 889933001345 putative homodimer interface [polypeptide binding]; other site 889933001346 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 889933001347 homodimer interface [polypeptide binding]; other site 889933001348 metal binding site [ion binding]; metal-binding site 889933001349 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889933001350 RNA binding surface [nucleotide binding]; other site 889933001351 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 889933001352 Septum formation initiator; Region: DivIC; pfam04977 889933001353 hypothetical protein; Provisional; Region: PRK08582 889933001354 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 889933001355 RNA binding site [nucleotide binding]; other site 889933001356 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 889933001357 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 889933001358 Ligand Binding Site [chemical binding]; other site 889933001359 TilS substrate C-terminal domain; Region: TilS_C; smart00977 889933001360 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 889933001361 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889933001362 active site 889933001363 FtsH Extracellular; Region: FtsH_ext; pfam06480 889933001364 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 889933001365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933001366 Walker A motif; other site 889933001367 ATP binding site [chemical binding]; other site 889933001368 Walker B motif; other site 889933001369 arginine finger; other site 889933001370 Peptidase family M41; Region: Peptidase_M41; pfam01434 889933001371 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 889933001372 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 889933001373 dimerization interface [polypeptide binding]; other site 889933001374 domain crossover interface; other site 889933001375 redox-dependent activation switch; other site 889933001376 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 889933001377 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 889933001378 dimer interface [polypeptide binding]; other site 889933001379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933001380 catalytic residue [active] 889933001381 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 889933001382 dihydropteroate synthase; Region: DHPS; TIGR01496 889933001383 substrate binding pocket [chemical binding]; other site 889933001384 dimer interface [polypeptide binding]; other site 889933001385 inhibitor binding site; inhibition site 889933001386 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 889933001387 homooctamer interface [polypeptide binding]; other site 889933001388 active site 889933001389 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 889933001390 catalytic center binding site [active] 889933001391 ATP binding site [chemical binding]; other site 889933001392 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 889933001393 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 889933001394 dimer interface [polypeptide binding]; other site 889933001395 putative anticodon binding site; other site 889933001396 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 889933001397 motif 1; other site 889933001398 active site 889933001399 motif 2; other site 889933001400 motif 3; other site 889933001401 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 889933001402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889933001403 DNA-binding site [nucleotide binding]; DNA binding site 889933001404 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889933001405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933001406 homodimer interface [polypeptide binding]; other site 889933001407 catalytic residue [active] 889933001408 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 889933001409 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 889933001410 active site 889933001411 multimer interface [polypeptide binding]; other site 889933001412 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 889933001413 predicted active site [active] 889933001414 catalytic triad [active] 889933001415 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 889933001416 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 889933001417 Nucleoside recognition; Region: Gate; pfam07670 889933001418 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 889933001419 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 889933001420 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 889933001421 UvrB/uvrC motif; Region: UVR; pfam02151 889933001422 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 889933001423 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 889933001424 ADP binding site [chemical binding]; other site 889933001425 phosphagen binding site; other site 889933001426 substrate specificity loop; other site 889933001427 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 889933001428 Clp amino terminal domain; Region: Clp_N; pfam02861 889933001429 Clp amino terminal domain; Region: Clp_N; pfam02861 889933001430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933001431 Walker A motif; other site 889933001432 ATP binding site [chemical binding]; other site 889933001433 Walker B motif; other site 889933001434 arginine finger; other site 889933001435 UvrB/uvrC motif; Region: UVR; pfam02151 889933001436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933001437 Walker A motif; other site 889933001438 ATP binding site [chemical binding]; other site 889933001439 Walker B motif; other site 889933001440 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 889933001441 DNA repair protein RadA; Provisional; Region: PRK11823 889933001442 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 889933001443 Walker A motif/ATP binding site; other site 889933001444 ATP binding site [chemical binding]; other site 889933001445 Walker B motif; other site 889933001446 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 889933001447 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 889933001448 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 889933001449 putative active site [active] 889933001450 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 889933001451 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 889933001452 active site 889933001453 HIGH motif; other site 889933001454 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 889933001455 active site 889933001456 KMSKS motif; other site 889933001457 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 889933001458 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 889933001459 trimer interface [polypeptide binding]; other site 889933001460 active site 889933001461 substrate binding site [chemical binding]; other site 889933001462 CoA binding site [chemical binding]; other site 889933001463 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 889933001464 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 889933001465 active site 889933001466 HIGH motif; other site 889933001467 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 889933001468 KMSKS motif; other site 889933001469 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 889933001470 tRNA binding surface [nucleotide binding]; other site 889933001471 anticodon binding site; other site 889933001472 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 889933001473 active site 889933001474 dimerization interface [polypeptide binding]; other site 889933001475 metal binding site [ion binding]; metal-binding site 889933001476 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 889933001477 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 889933001478 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 889933001479 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 889933001480 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 889933001481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889933001482 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 889933001483 DNA binding residues [nucleotide binding] 889933001484 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 889933001485 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 889933001486 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 889933001487 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 889933001488 putative homodimer interface [polypeptide binding]; other site 889933001489 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 889933001490 heterodimer interface [polypeptide binding]; other site 889933001491 homodimer interface [polypeptide binding]; other site 889933001492 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 889933001493 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 889933001494 23S rRNA interface [nucleotide binding]; other site 889933001495 L7/L12 interface [polypeptide binding]; other site 889933001496 putative thiostrepton binding site; other site 889933001497 L25 interface [polypeptide binding]; other site 889933001498 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 889933001499 mRNA/rRNA interface [nucleotide binding]; other site 889933001500 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 889933001501 23S rRNA interface [nucleotide binding]; other site 889933001502 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 889933001503 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 889933001504 peripheral dimer interface [polypeptide binding]; other site 889933001505 core dimer interface [polypeptide binding]; other site 889933001506 L10 interface [polypeptide binding]; other site 889933001507 L11 interface [polypeptide binding]; other site 889933001508 putative EF-Tu interaction site [polypeptide binding]; other site 889933001509 putative EF-G interaction site [polypeptide binding]; other site 889933001510 Methyltransferase domain; Region: Methyltransf_31; pfam13847 889933001511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933001512 S-adenosylmethionine binding site [chemical binding]; other site 889933001513 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 889933001514 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 889933001515 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 889933001516 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 889933001517 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 889933001518 RPB10 interaction site [polypeptide binding]; other site 889933001519 RPB1 interaction site [polypeptide binding]; other site 889933001520 RPB11 interaction site [polypeptide binding]; other site 889933001521 RPB3 interaction site [polypeptide binding]; other site 889933001522 RPB12 interaction site [polypeptide binding]; other site 889933001523 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 889933001524 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 889933001525 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 889933001526 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 889933001527 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 889933001528 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 889933001529 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 889933001530 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 889933001531 G-loop; other site 889933001532 DNA binding site [nucleotide binding] 889933001533 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 889933001534 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 889933001535 S17 interaction site [polypeptide binding]; other site 889933001536 S8 interaction site; other site 889933001537 16S rRNA interaction site [nucleotide binding]; other site 889933001538 streptomycin interaction site [chemical binding]; other site 889933001539 23S rRNA interaction site [nucleotide binding]; other site 889933001540 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 889933001541 30S ribosomal protein S7; Validated; Region: PRK05302 889933001542 elongation factor G; Reviewed; Region: PRK00007 889933001543 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 889933001544 G1 box; other site 889933001545 putative GEF interaction site [polypeptide binding]; other site 889933001546 GTP/Mg2+ binding site [chemical binding]; other site 889933001547 Switch I region; other site 889933001548 G2 box; other site 889933001549 G3 box; other site 889933001550 Switch II region; other site 889933001551 G4 box; other site 889933001552 G5 box; other site 889933001553 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 889933001554 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 889933001555 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 889933001556 elongation factor Tu; Reviewed; Region: PRK00049 889933001557 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 889933001558 G1 box; other site 889933001559 GEF interaction site [polypeptide binding]; other site 889933001560 GTP/Mg2+ binding site [chemical binding]; other site 889933001561 Switch I region; other site 889933001562 G2 box; other site 889933001563 G3 box; other site 889933001564 Switch II region; other site 889933001565 G4 box; other site 889933001566 G5 box; other site 889933001567 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 889933001568 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 889933001569 Antibiotic Binding Site [chemical binding]; other site 889933001570 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 889933001571 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 889933001572 metal binding site [ion binding]; metal-binding site 889933001573 dimer interface [polypeptide binding]; other site 889933001574 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 889933001575 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 889933001576 substrate-cofactor binding pocket; other site 889933001577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933001578 catalytic residue [active] 889933001579 chaperone protein HchA; Provisional; Region: PRK04155 889933001580 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 889933001581 dimer interface [polypeptide binding]; other site 889933001582 metal binding site [ion binding]; metal-binding site 889933001583 potential oxyanion hole; other site 889933001584 potential catalytic triad [active] 889933001585 conserved cys residue [active] 889933001586 ribulokinase; Provisional; Region: PRK04123 889933001587 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 889933001588 N- and C-terminal domain interface [polypeptide binding]; other site 889933001589 active site 889933001590 MgATP binding site [chemical binding]; other site 889933001591 catalytic site [active] 889933001592 metal binding site [ion binding]; metal-binding site 889933001593 carbohydrate binding site [chemical binding]; other site 889933001594 homodimer interface [polypeptide binding]; other site 889933001595 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 889933001596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889933001597 NAD(P) binding site [chemical binding]; other site 889933001598 active site 889933001599 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 889933001600 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 889933001601 homodimer interface [polypeptide binding]; other site 889933001602 substrate-cofactor binding pocket; other site 889933001603 catalytic residue [active] 889933001604 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 889933001605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933001606 motif II; other site 889933001607 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 889933001608 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 889933001609 Substrate-binding site [chemical binding]; other site 889933001610 Substrate specificity [chemical binding]; other site 889933001611 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 889933001612 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 889933001613 Substrate-binding site [chemical binding]; other site 889933001614 Substrate specificity [chemical binding]; other site 889933001615 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 889933001616 nucleoside/Zn binding site; other site 889933001617 dimer interface [polypeptide binding]; other site 889933001618 catalytic motif [active] 889933001619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933001620 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889933001621 active site 889933001622 motif I; other site 889933001623 motif II; other site 889933001624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933001625 Predicted flavoprotein [General function prediction only]; Region: COG0431 889933001626 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 889933001627 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933001628 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 889933001629 Cna protein B-type domain; Region: Cna_B; pfam05738 889933001630 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 889933001631 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933001632 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 889933001633 Cna protein B-type domain; Region: Cna_B; pfam05738 889933001634 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 889933001635 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 889933001636 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 889933001637 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 889933001638 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933001639 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 889933001640 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 889933001641 Cna protein B-type domain; Region: Cna_B; pfam05738 889933001642 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 889933001643 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 889933001644 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 889933001645 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889933001646 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 889933001647 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 889933001648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889933001649 putative GTP cyclohydrolase; Provisional; Region: PRK13674 889933001650 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 889933001651 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 889933001652 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 889933001653 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 889933001654 active site 889933001655 trimer interface [polypeptide binding]; other site 889933001656 allosteric site; other site 889933001657 active site lid [active] 889933001658 hexamer (dimer of trimers) interface [polypeptide binding]; other site 889933001659 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 889933001660 active site 889933001661 dimer interface [polypeptide binding]; other site 889933001662 magnesium binding site [ion binding]; other site 889933001663 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 889933001664 tetramer interface [polypeptide binding]; other site 889933001665 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 889933001666 active site 889933001667 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 889933001668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933001669 motif II; other site 889933001670 proline/glycine betaine transporter; Provisional; Region: PRK10642 889933001671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933001672 putative substrate translocation pore; other site 889933001673 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 889933001674 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 889933001675 acyl-activating enzyme (AAE) consensus motif; other site 889933001676 AMP binding site [chemical binding]; other site 889933001677 active site 889933001678 CoA binding site [chemical binding]; other site 889933001679 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 889933001680 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 889933001681 dimer interface [polypeptide binding]; other site 889933001682 active site 889933001683 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 889933001684 dimer interface [polypeptide binding]; other site 889933001685 substrate binding site [chemical binding]; other site 889933001686 ATP binding site [chemical binding]; other site 889933001687 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 889933001688 ligand binding site [chemical binding]; other site 889933001689 active site 889933001690 UGI interface [polypeptide binding]; other site 889933001691 catalytic site [active] 889933001692 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 889933001693 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 889933001694 Uncharacterized conserved protein [Function unknown]; Region: COG3610 889933001695 Uncharacterized conserved protein [Function unknown]; Region: COG2966 889933001696 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 889933001697 putative heme peroxidase; Provisional; Region: PRK12276 889933001698 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 889933001699 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 889933001700 mevalonate kinase; Region: mevalon_kin; TIGR00549 889933001701 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 889933001702 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 889933001703 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 889933001704 diphosphomevalonate decarboxylase; Region: PLN02407 889933001705 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 889933001706 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 889933001707 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 889933001708 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 889933001709 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 889933001710 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 889933001711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933001712 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889933001713 Predicted transcriptional regulator [Transcription]; Region: COG1959 889933001714 Transcriptional regulator; Region: Rrf2; pfam02082 889933001715 LXG domain of WXG superfamily; Region: LXG; pfam04740 889933001716 Protein of unknown function (DUF443); Region: DUF443; pfam04276 889933001717 Protein of unknown function (DUF443); Region: DUF443; pfam04276 889933001718 Protein of unknown function (DUF443); Region: DUF443; pfam04276 889933001719 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889933001720 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889933001721 active site 889933001722 catalytic tetrad [active] 889933001723 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 889933001724 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 889933001725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 889933001726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933001727 Coenzyme A binding pocket [chemical binding]; other site 889933001728 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 889933001729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889933001730 Zn2+ binding site [ion binding]; other site 889933001731 Mg2+ binding site [ion binding]; other site 889933001732 YwhD family; Region: YwhD; pfam08741 889933001733 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 889933001734 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 889933001735 NAD binding site [chemical binding]; other site 889933001736 substrate binding site [chemical binding]; other site 889933001737 catalytic Zn binding site [ion binding]; other site 889933001738 tetramer interface [polypeptide binding]; other site 889933001739 structural Zn binding site [ion binding]; other site 889933001740 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 889933001741 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 889933001742 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 889933001743 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 889933001744 active site 889933001745 HIGH motif; other site 889933001746 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889933001747 KMSK motif region; other site 889933001748 tRNA binding surface [nucleotide binding]; other site 889933001749 DALR anticodon binding domain; Region: DALR_1; smart00836 889933001750 anticodon binding site; other site 889933001751 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 889933001752 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 889933001753 minor groove reading motif; other site 889933001754 helix-hairpin-helix signature motif; other site 889933001755 substrate binding pocket [chemical binding]; other site 889933001756 active site 889933001757 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 889933001758 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 889933001759 putative binding site residues; other site 889933001760 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933001761 ABC-ATPase subunit interface; other site 889933001762 dimer interface [polypeptide binding]; other site 889933001763 putative PBP binding regions; other site 889933001764 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 889933001765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933001766 motif II; other site 889933001767 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 889933001768 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 889933001769 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 889933001770 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 889933001771 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933001772 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889933001773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 889933001774 Protein of unknown function, DUF606; Region: DUF606; pfam04657 889933001775 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 889933001776 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 889933001777 active site 889933001778 DNA binding site [nucleotide binding] 889933001779 Int/Topo IB signature motif; other site 889933001780 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 889933001781 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 889933001782 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 889933001783 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 889933001784 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 889933001785 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 889933001786 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 889933001787 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 889933001788 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 889933001789 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 889933001790 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 889933001791 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889933001792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889933001793 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889933001794 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 889933001795 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 889933001796 metal binding site [ion binding]; metal-binding site 889933001797 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 889933001798 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933001799 ABC-ATPase subunit interface; other site 889933001800 dimer interface [polypeptide binding]; other site 889933001801 putative PBP binding regions; other site 889933001802 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 889933001803 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 889933001804 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 889933001805 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 889933001806 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 889933001807 FeoA domain; Region: FeoA; pfam04023 889933001808 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 889933001809 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 889933001810 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 889933001811 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 889933001812 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 889933001813 Walker A/P-loop; other site 889933001814 ATP binding site [chemical binding]; other site 889933001815 Q-loop/lid; other site 889933001816 ABC transporter signature motif; other site 889933001817 Walker B; other site 889933001818 D-loop; other site 889933001819 H-loop/switch region; other site 889933001820 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 889933001821 ABC-2 type transporter; Region: ABC2_membrane; cl17235 889933001822 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 889933001823 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 889933001824 active site 889933001825 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889933001826 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 889933001827 active site 889933001828 nucleotide binding site [chemical binding]; other site 889933001829 HIGH motif; other site 889933001830 KMSKS motif; other site 889933001831 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 889933001832 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 889933001833 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 889933001834 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889933001835 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 889933001836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933001837 Walker A/P-loop; other site 889933001838 ATP binding site [chemical binding]; other site 889933001839 Q-loop/lid; other site 889933001840 ABC transporter signature motif; other site 889933001841 Walker B; other site 889933001842 D-loop; other site 889933001843 H-loop/switch region; other site 889933001844 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 889933001845 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 889933001846 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 889933001847 Uncharacterized conserved protein [Function unknown]; Region: COG1284 889933001848 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 889933001849 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 889933001850 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889933001851 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889933001852 Walker A/P-loop; other site 889933001853 ATP binding site [chemical binding]; other site 889933001854 Q-loop/lid; other site 889933001855 ABC transporter signature motif; other site 889933001856 Walker B; other site 889933001857 D-loop; other site 889933001858 H-loop/switch region; other site 889933001859 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 889933001860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933001861 ABC-ATPase subunit interface; other site 889933001862 dimer interface [polypeptide binding]; other site 889933001863 putative PBP binding regions; other site 889933001864 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 889933001865 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933001866 ABC-ATPase subunit interface; other site 889933001867 dimer interface [polypeptide binding]; other site 889933001868 putative PBP binding regions; other site 889933001869 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 889933001870 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 889933001871 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 889933001872 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 889933001873 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 889933001874 Uncharacterized membrane protein [Function unknown]; Region: COG3949 889933001875 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 889933001876 Na binding site [ion binding]; other site 889933001877 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 889933001878 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 889933001879 substrate binding pocket [chemical binding]; other site 889933001880 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 889933001881 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 889933001882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933001883 Coenzyme A binding pocket [chemical binding]; other site 889933001884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 889933001885 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 889933001886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889933001887 NAD(P) binding site [chemical binding]; other site 889933001888 active site 889933001889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889933001890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933001891 active site 889933001892 phosphorylation site [posttranslational modification] 889933001893 intermolecular recognition site; other site 889933001894 dimerization interface [polypeptide binding]; other site 889933001895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889933001896 DNA binding site [nucleotide binding] 889933001897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 889933001898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 889933001899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933001900 ATP binding site [chemical binding]; other site 889933001901 Mg2+ binding site [ion binding]; other site 889933001902 G-X-G motif; other site 889933001903 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889933001904 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 889933001905 Walker A/P-loop; other site 889933001906 ATP binding site [chemical binding]; other site 889933001907 Q-loop/lid; other site 889933001908 ABC transporter signature motif; other site 889933001909 Walker B; other site 889933001910 D-loop; other site 889933001911 H-loop/switch region; other site 889933001912 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 889933001913 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 889933001914 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 889933001915 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 889933001916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 889933001917 Surface antigen [General function prediction only]; Region: COG3942 889933001918 CHAP domain; Region: CHAP; pfam05257 889933001919 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 889933001920 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 889933001921 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 889933001922 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933001923 hypothetical protein; Provisional; Region: PRK12378 889933001924 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 889933001925 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 889933001926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889933001927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 889933001928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889933001929 dimerization interface [polypeptide binding]; other site 889933001930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933001931 sugar efflux transporter; Region: 2A0120; TIGR00899 889933001932 putative substrate translocation pore; other site 889933001933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 889933001934 Serine incorporator (Serinc); Region: Serinc; pfam03348 889933001935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933001936 Coenzyme A binding pocket [chemical binding]; other site 889933001937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 889933001938 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 889933001939 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 889933001940 hypothetical protein; Validated; Region: PRK00124 889933001941 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 889933001942 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 889933001943 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 889933001944 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 889933001945 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 889933001946 Walker A/P-loop; other site 889933001947 ATP binding site [chemical binding]; other site 889933001948 Q-loop/lid; other site 889933001949 ABC transporter signature motif; other site 889933001950 Walker B; other site 889933001951 D-loop; other site 889933001952 H-loop/switch region; other site 889933001953 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 889933001954 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 889933001955 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 889933001956 Walker A/P-loop; other site 889933001957 ATP binding site [chemical binding]; other site 889933001958 Q-loop/lid; other site 889933001959 ABC transporter signature motif; other site 889933001960 Walker B; other site 889933001961 D-loop; other site 889933001962 H-loop/switch region; other site 889933001963 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889933001964 MarR family; Region: MarR; pfam01047 889933001965 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 889933001966 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 889933001967 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 889933001968 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889933001969 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889933001970 active site 889933001971 catalytic tetrad [active] 889933001972 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 889933001973 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 889933001974 transmembrane helices; other site 889933001975 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 889933001976 DNA photolyase; Region: DNA_photolyase; pfam00875 889933001977 Predicted membrane protein [Function unknown]; Region: COG4330 889933001978 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 889933001979 trimer interface [polypeptide binding]; other site 889933001980 putative Zn binding site [ion binding]; other site 889933001981 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 889933001982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933001983 putative substrate translocation pore; other site 889933001984 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 889933001985 putative deacylase active site [active] 889933001986 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 889933001987 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 889933001988 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 889933001989 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 889933001990 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 889933001991 putative substrate binding site [chemical binding]; other site 889933001992 putative ATP binding site [chemical binding]; other site 889933001993 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 889933001994 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889933001995 active site 889933001996 phosphorylation site [posttranslational modification] 889933001997 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 889933001998 active site 889933001999 P-loop; other site 889933002000 phosphorylation site [posttranslational modification] 889933002001 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 889933002002 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 889933002003 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 889933002004 active site 889933002005 dimer interface [polypeptide binding]; other site 889933002006 Domain of unknown function DUF21; Region: DUF21; pfam01595 889933002007 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 889933002008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 889933002009 Transporter associated domain; Region: CorC_HlyC; pfam03471 889933002010 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889933002011 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889933002012 active site 889933002013 catalytic tetrad [active] 889933002014 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 889933002015 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 889933002016 Ligand binding site; other site 889933002017 Putative Catalytic site; other site 889933002018 DXD motif; other site 889933002019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 889933002020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889933002021 dimer interface [polypeptide binding]; other site 889933002022 phosphorylation site [posttranslational modification] 889933002023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933002024 ATP binding site [chemical binding]; other site 889933002025 Mg2+ binding site [ion binding]; other site 889933002026 G-X-G motif; other site 889933002027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889933002028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933002029 active site 889933002030 phosphorylation site [posttranslational modification] 889933002031 intermolecular recognition site; other site 889933002032 dimerization interface [polypeptide binding]; other site 889933002033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889933002034 DNA binding site [nucleotide binding] 889933002035 DoxX; Region: DoxX; pfam07681 889933002036 Electron transfer DM13; Region: DM13; pfam10517 889933002037 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 889933002038 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 889933002039 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 889933002040 active site 889933002041 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 889933002042 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 889933002043 Ligand Binding Site [chemical binding]; other site 889933002044 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 889933002045 Glutamine amidotransferase class-I; Region: GATase; pfam00117 889933002046 glutamine binding [chemical binding]; other site 889933002047 catalytic triad [active] 889933002048 aminodeoxychorismate synthase; Provisional; Region: PRK07508 889933002049 chorismate binding enzyme; Region: Chorismate_bind; cl10555 889933002050 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 889933002051 substrate-cofactor binding pocket; other site 889933002052 Aminotransferase class IV; Region: Aminotran_4; pfam01063 889933002053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933002054 catalytic residue [active] 889933002055 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 889933002056 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 889933002057 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 889933002058 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 889933002059 Sulfatase; Region: Sulfatase; pfam00884 889933002060 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 889933002061 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 889933002062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 889933002063 ABC transporter; Region: ABC_tran_2; pfam12848 889933002064 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 889933002065 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 889933002066 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889933002067 ATP binding site [chemical binding]; other site 889933002068 putative Mg++ binding site [ion binding]; other site 889933002069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889933002070 nucleotide binding region [chemical binding]; other site 889933002071 ATP-binding site [chemical binding]; other site 889933002072 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 889933002073 HRDC domain; Region: HRDC; pfam00570 889933002074 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 889933002075 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 889933002076 Walker A/P-loop; other site 889933002077 ATP binding site [chemical binding]; other site 889933002078 Q-loop/lid; other site 889933002079 ABC transporter signature motif; other site 889933002080 Walker B; other site 889933002081 D-loop; other site 889933002082 H-loop/switch region; other site 889933002083 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 889933002084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933002085 dimer interface [polypeptide binding]; other site 889933002086 conserved gate region; other site 889933002087 ABC-ATPase subunit interface; other site 889933002088 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 889933002089 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 889933002090 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 889933002091 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889933002092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933002093 homodimer interface [polypeptide binding]; other site 889933002094 catalytic residue [active] 889933002095 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 889933002096 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 889933002097 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 889933002098 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 889933002099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933002100 putative substrate translocation pore; other site 889933002101 POT family; Region: PTR2; cl17359 889933002102 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 889933002103 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 889933002104 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 889933002105 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 889933002106 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 889933002107 Class I ribonucleotide reductase; Region: RNR_I; cd01679 889933002108 active site 889933002109 dimer interface [polypeptide binding]; other site 889933002110 catalytic residues [active] 889933002111 effector binding site; other site 889933002112 R2 peptide binding site; other site 889933002113 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 889933002114 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 889933002115 dimer interface [polypeptide binding]; other site 889933002116 putative radical transfer pathway; other site 889933002117 diiron center [ion binding]; other site 889933002118 tyrosyl radical; other site 889933002119 potential frameshift: common BLAST hit: gi|161509000|ref|YP_001574659.1| iron (Fe+3) ABC transporter membrane protein 889933002120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 889933002121 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 889933002122 putative PBP binding regions; other site 889933002123 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933002124 ABC-ATPase subunit interface; other site 889933002125 dimer interface [polypeptide binding]; other site 889933002126 putative PBP binding regions; other site 889933002127 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 889933002128 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889933002129 Walker A/P-loop; other site 889933002130 ATP binding site [chemical binding]; other site 889933002131 Q-loop/lid; other site 889933002132 ABC transporter signature motif; other site 889933002133 Walker B; other site 889933002134 D-loop; other site 889933002135 H-loop/switch region; other site 889933002136 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 889933002137 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 889933002138 putative ligand binding residues [chemical binding]; other site 889933002139 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 889933002140 FAD binding domain; Region: FAD_binding_4; pfam01565 889933002141 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 889933002142 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 889933002143 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 889933002144 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 889933002145 peptidase T; Region: peptidase-T; TIGR01882 889933002146 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 889933002147 metal binding site [ion binding]; metal-binding site 889933002148 dimer interface [polypeptide binding]; other site 889933002149 Uncharacterized conserved protein [Function unknown]; Region: COG3610 889933002150 Uncharacterized conserved protein [Function unknown]; Region: COG2966 889933002151 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 889933002152 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 889933002153 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 889933002154 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 889933002155 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 889933002156 metal binding site [ion binding]; metal-binding site 889933002157 active site 889933002158 I-site; other site 889933002159 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 889933002160 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 889933002161 Mg++ binding site [ion binding]; other site 889933002162 putative catalytic motif [active] 889933002163 substrate binding site [chemical binding]; other site 889933002164 Uncharacterized conserved protein [Function unknown]; Region: COG1739 889933002165 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 889933002166 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 889933002167 EDD domain protein, DegV family; Region: DegV; TIGR00762 889933002168 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 889933002169 DEAD-like helicases superfamily; Region: DEXDc; smart00487 889933002170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889933002171 ATP binding site [chemical binding]; other site 889933002172 putative Mg++ binding site [ion binding]; other site 889933002173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889933002174 nucleotide binding region [chemical binding]; other site 889933002175 ATP-binding site [chemical binding]; other site 889933002176 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 889933002177 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889933002178 active site 889933002179 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 889933002180 30S subunit binding site; other site 889933002181 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 889933002182 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 889933002183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 889933002184 nucleotide binding region [chemical binding]; other site 889933002185 ATP-binding site [chemical binding]; other site 889933002186 SEC-C motif; Region: SEC-C; pfam02810 889933002187 peptide chain release factor 2; Provisional; Region: PRK06746 889933002188 This domain is found in peptide chain release factors; Region: PCRF; smart00937 889933002189 RF-1 domain; Region: RF-1; pfam00472 889933002190 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 889933002191 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 889933002192 Surface antigen [General function prediction only]; Region: COG3942 889933002193 CHAP domain; Region: CHAP; pfam05257 889933002194 HD domain; Region: HD_3; cl17350 889933002195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 889933002196 excinuclease ABC subunit B; Provisional; Region: PRK05298 889933002197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889933002198 ATP binding site [chemical binding]; other site 889933002199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889933002200 nucleotide binding region [chemical binding]; other site 889933002201 ATP-binding site [chemical binding]; other site 889933002202 Ultra-violet resistance protein B; Region: UvrB; pfam12344 889933002203 UvrB/uvrC motif; Region: UVR; pfam02151 889933002204 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 889933002205 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 889933002206 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 889933002207 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 889933002208 HPr kinase/phosphorylase; Provisional; Region: PRK05428 889933002209 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 889933002210 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 889933002211 Hpr binding site; other site 889933002212 active site 889933002213 homohexamer subunit interaction site [polypeptide binding]; other site 889933002214 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 889933002215 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 889933002216 putative trimer interface [polypeptide binding]; other site 889933002217 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 889933002218 putative CoA binding site [chemical binding]; other site 889933002219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 889933002220 binding surface 889933002221 TPR motif; other site 889933002222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 889933002223 TPR motif; other site 889933002224 binding surface 889933002225 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 889933002226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 889933002227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933002228 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 889933002229 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 889933002230 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 889933002231 phosphate binding site [ion binding]; other site 889933002232 dimer interface [polypeptide binding]; other site 889933002233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 889933002234 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 889933002235 Clp protease; Region: CLP_protease; pfam00574 889933002236 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 889933002237 oligomer interface [polypeptide binding]; other site 889933002238 active site residues [active] 889933002239 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 889933002240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889933002241 NAD(P) binding site [chemical binding]; other site 889933002242 active site 889933002243 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 889933002244 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 889933002245 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 889933002246 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 889933002247 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 889933002248 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 889933002249 Phosphoglycerate kinase; Region: PGK; pfam00162 889933002250 substrate binding site [chemical binding]; other site 889933002251 hinge regions; other site 889933002252 ADP binding site [chemical binding]; other site 889933002253 catalytic site [active] 889933002254 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 889933002255 triosephosphate isomerase; Provisional; Region: PRK14565 889933002256 substrate binding site [chemical binding]; other site 889933002257 dimer interface [polypeptide binding]; other site 889933002258 catalytic triad [active] 889933002259 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 889933002260 phosphoglyceromutase; Provisional; Region: PRK05434 889933002261 enolase; Provisional; Region: eno; PRK00077 889933002262 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 889933002263 dimer interface [polypeptide binding]; other site 889933002264 metal binding site [ion binding]; metal-binding site 889933002265 substrate binding pocket [chemical binding]; other site 889933002266 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 889933002267 Esterase/lipase [General function prediction only]; Region: COG1647 889933002268 ribonuclease R; Region: RNase_R; TIGR02063 889933002269 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 889933002270 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 889933002271 RNB domain; Region: RNB; pfam00773 889933002272 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 889933002273 RNA binding site [nucleotide binding]; other site 889933002274 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 889933002275 SmpB-tmRNA interface; other site 889933002276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933002277 Coenzyme A binding pocket [chemical binding]; other site 889933002278 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933002279 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 889933002280 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 889933002281 Staphylococcal nuclease homologues; Region: SNc; smart00318 889933002282 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 889933002283 Catalytic site; other site 889933002284 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 889933002285 DNA-binding site [nucleotide binding]; DNA binding site 889933002286 RNA-binding motif; other site 889933002287 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 889933002288 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 889933002289 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889933002290 catalytic core [active] 889933002291 Lysine efflux permease [General function prediction only]; Region: COG1279 889933002292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 889933002293 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 889933002294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 889933002295 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 889933002296 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 889933002297 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 889933002298 active site 889933002299 catalytic residue [active] 889933002300 dimer interface [polypeptide binding]; other site 889933002301 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 889933002302 putative FMN binding site [chemical binding]; other site 889933002303 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889933002304 catalytic residues [active] 889933002305 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 889933002306 ArsC family; Region: ArsC; pfam03960 889933002307 putative ArsC-like catalytic residues; other site 889933002308 putative TRX-like catalytic residues [active] 889933002309 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 889933002310 lipoyl attachment site [posttranslational modification]; other site 889933002311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 889933002312 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 889933002313 putative active site [active] 889933002314 putative metal binding site [ion binding]; other site 889933002315 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889933002316 catalytic residues [active] 889933002317 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 889933002318 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 889933002319 Walker A/P-loop; other site 889933002320 ATP binding site [chemical binding]; other site 889933002321 Q-loop/lid; other site 889933002322 ABC transporter signature motif; other site 889933002323 Walker B; other site 889933002324 D-loop; other site 889933002325 H-loop/switch region; other site 889933002326 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 889933002327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933002328 dimer interface [polypeptide binding]; other site 889933002329 conserved gate region; other site 889933002330 ABC-ATPase subunit interface; other site 889933002331 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 889933002332 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 889933002333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 889933002334 Predicted membrane protein [Function unknown]; Region: COG2035 889933002335 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 889933002336 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 889933002337 Walker A/P-loop; other site 889933002338 ATP binding site [chemical binding]; other site 889933002339 Q-loop/lid; other site 889933002340 ABC transporter signature motif; other site 889933002341 Walker B; other site 889933002342 D-loop; other site 889933002343 H-loop/switch region; other site 889933002344 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 889933002345 FeS assembly protein SufD; Region: sufD; TIGR01981 889933002346 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 889933002347 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 889933002348 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889933002349 catalytic residue [active] 889933002350 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 889933002351 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 889933002352 trimerization site [polypeptide binding]; other site 889933002353 active site 889933002354 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 889933002355 FeS assembly protein SufB; Region: sufB; TIGR01980 889933002356 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 889933002357 Domain of unknown function DUF21; Region: DUF21; pfam01595 889933002358 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 889933002359 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 889933002360 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 889933002361 FMN binding site [chemical binding]; other site 889933002362 substrate binding site [chemical binding]; other site 889933002363 putative catalytic residue [active] 889933002364 Uncharacterized conserved protein [Function unknown]; Region: COG1801 889933002365 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 889933002366 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 889933002367 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 889933002368 active site 889933002369 metal binding site [ion binding]; metal-binding site 889933002370 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 889933002371 lipoyl synthase; Provisional; Region: PRK05481 889933002372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889933002373 FeS/SAM binding site; other site 889933002374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 889933002375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889933002376 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889933002377 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 889933002378 Uncharacterized conserved protein [Function unknown]; Region: COG2445 889933002379 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 889933002380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933002381 active site 889933002382 motif I; other site 889933002383 motif II; other site 889933002384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933002385 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 889933002386 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 889933002387 dimerization interface [polypeptide binding]; other site 889933002388 ligand binding site [chemical binding]; other site 889933002389 NADP binding site [chemical binding]; other site 889933002390 catalytic site [active] 889933002391 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 889933002392 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 889933002393 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 889933002394 acyl-activating enzyme (AAE) consensus motif; other site 889933002395 AMP binding site [chemical binding]; other site 889933002396 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 889933002397 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 889933002398 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 889933002399 DltD N-terminal region; Region: DltD_N; pfam04915 889933002400 DltD central region; Region: DltD_M; pfam04918 889933002401 DltD C-terminal region; Region: DltD_C; pfam04914 889933002402 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 889933002403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 889933002404 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 889933002405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933002406 hypothetical protein; Provisional; Region: PRK13669 889933002407 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 889933002408 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 889933002409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933002410 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 889933002411 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 889933002412 interface (dimer of trimers) [polypeptide binding]; other site 889933002413 Substrate-binding/catalytic site; other site 889933002414 Zn-binding sites [ion binding]; other site 889933002415 Predicted permease [General function prediction only]; Region: COG2056 889933002416 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 889933002417 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 889933002418 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 889933002419 CoenzymeA binding site [chemical binding]; other site 889933002420 subunit interaction site [polypeptide binding]; other site 889933002421 PHB binding site; other site 889933002422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 889933002423 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 889933002424 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 889933002425 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 889933002426 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 889933002427 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 889933002428 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 889933002429 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 889933002430 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 889933002431 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 889933002432 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 889933002433 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 889933002434 Kinase associated protein B; Region: KapB; pfam08810 889933002435 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 889933002436 active site 889933002437 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 889933002438 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 889933002439 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 889933002440 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 889933002441 putative active site [active] 889933002442 putative FMN binding site [chemical binding]; other site 889933002443 putative substrate binding site [chemical binding]; other site 889933002444 putative catalytic residue [active] 889933002445 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 889933002446 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889933002447 inhibitor-cofactor binding pocket; inhibition site 889933002448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933002449 catalytic residue [active] 889933002450 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 889933002451 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 889933002452 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 889933002453 NAD(P) binding site [chemical binding]; other site 889933002454 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 889933002455 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 889933002456 active site 889933002457 catalytic site [active] 889933002458 metal binding site [ion binding]; metal-binding site 889933002459 argininosuccinate lyase; Provisional; Region: PRK00855 889933002460 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 889933002461 active sites [active] 889933002462 tetramer interface [polypeptide binding]; other site 889933002463 argininosuccinate synthase; Provisional; Region: PRK13820 889933002464 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 889933002465 ANP binding site [chemical binding]; other site 889933002466 Substrate Binding Site II [chemical binding]; other site 889933002467 Substrate Binding Site I [chemical binding]; other site 889933002468 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 889933002469 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 889933002470 active site 889933002471 dimer interface [polypeptide binding]; other site 889933002472 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 889933002473 dimer interface [polypeptide binding]; other site 889933002474 active site 889933002475 Uncharacterized conserved protein [Function unknown]; Region: COG0398 889933002476 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 889933002477 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 889933002478 Catalytic site [active] 889933002479 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 889933002480 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 889933002481 Catalytic site [active] 889933002482 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 889933002483 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 889933002484 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 889933002485 Part of AAA domain; Region: AAA_19; pfam13245 889933002486 Family description; Region: UvrD_C_2; pfam13538 889933002487 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 889933002488 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 889933002489 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 889933002490 hypothetical protein; Provisional; Region: PRK13673 889933002491 coenzyme A disulfide reductase; Provisional; Region: PRK13512 889933002492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 889933002493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933002494 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889933002495 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 889933002496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933002497 active site 889933002498 motif I; other site 889933002499 motif II; other site 889933002500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933002501 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 889933002502 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 889933002503 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 889933002504 catalytic triad [active] 889933002505 catalytic triad [active] 889933002506 oxyanion hole [active] 889933002507 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 889933002508 Clp amino terminal domain; Region: Clp_N; pfam02861 889933002509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933002510 Walker A motif; other site 889933002511 ATP binding site [chemical binding]; other site 889933002512 Walker B motif; other site 889933002513 arginine finger; other site 889933002514 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 889933002515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933002516 Walker A motif; other site 889933002517 ATP binding site [chemical binding]; other site 889933002518 Walker B motif; other site 889933002519 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 889933002520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889933002521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 889933002522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889933002523 dimerization interface [polypeptide binding]; other site 889933002524 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 889933002525 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 889933002526 active site 889933002527 catalytic residues [active] 889933002528 metal binding site [ion binding]; metal-binding site 889933002529 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 889933002530 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 889933002531 substrate binding site [chemical binding]; other site 889933002532 MAP domain; Region: MAP; pfam03642 889933002533 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 889933002534 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 889933002535 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 889933002536 dimer interface [polypeptide binding]; other site 889933002537 active site 889933002538 CoA binding pocket [chemical binding]; other site 889933002539 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 889933002540 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 889933002541 dimer interface [polypeptide binding]; other site 889933002542 active site 889933002543 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 889933002544 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889933002545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933002546 dimer interface [polypeptide binding]; other site 889933002547 conserved gate region; other site 889933002548 putative PBP binding loops; other site 889933002549 ABC-ATPase subunit interface; other site 889933002550 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 889933002551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933002552 dimer interface [polypeptide binding]; other site 889933002553 conserved gate region; other site 889933002554 putative PBP binding loops; other site 889933002555 ABC-ATPase subunit interface; other site 889933002556 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 889933002557 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 889933002558 Walker A/P-loop; other site 889933002559 ATP binding site [chemical binding]; other site 889933002560 Q-loop/lid; other site 889933002561 ABC transporter signature motif; other site 889933002562 Walker B; other site 889933002563 D-loop; other site 889933002564 H-loop/switch region; other site 889933002565 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889933002566 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 889933002567 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 889933002568 Walker A/P-loop; other site 889933002569 ATP binding site [chemical binding]; other site 889933002570 Q-loop/lid; other site 889933002571 ABC transporter signature motif; other site 889933002572 Walker B; other site 889933002573 D-loop; other site 889933002574 H-loop/switch region; other site 889933002575 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889933002576 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 889933002577 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 889933002578 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 889933002579 peptide binding site [polypeptide binding]; other site 889933002580 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 889933002581 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 889933002582 peptide binding site [polypeptide binding]; other site 889933002583 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 889933002584 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 889933002585 Walker A/P-loop; other site 889933002586 ATP binding site [chemical binding]; other site 889933002587 Q-loop/lid; other site 889933002588 ABC transporter signature motif; other site 889933002589 Walker B; other site 889933002590 D-loop; other site 889933002591 H-loop/switch region; other site 889933002592 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889933002593 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 889933002594 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 889933002595 Walker A/P-loop; other site 889933002596 ATP binding site [chemical binding]; other site 889933002597 Q-loop/lid; other site 889933002598 ABC transporter signature motif; other site 889933002599 Walker B; other site 889933002600 D-loop; other site 889933002601 H-loop/switch region; other site 889933002602 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 889933002603 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889933002604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933002605 dimer interface [polypeptide binding]; other site 889933002606 conserved gate region; other site 889933002607 putative PBP binding loops; other site 889933002608 ABC-ATPase subunit interface; other site 889933002609 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 889933002610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933002611 dimer interface [polypeptide binding]; other site 889933002612 conserved gate region; other site 889933002613 putative PBP binding loops; other site 889933002614 ABC-ATPase subunit interface; other site 889933002615 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 889933002616 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 889933002617 active site 889933002618 HIGH motif; other site 889933002619 dimer interface [polypeptide binding]; other site 889933002620 KMSKS motif; other site 889933002621 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 889933002622 ArsC family; Region: ArsC; pfam03960 889933002623 putative catalytic residues [active] 889933002624 thiol/disulfide switch; other site 889933002625 adaptor protein; Provisional; Region: PRK02315 889933002626 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 889933002627 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 889933002628 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 889933002629 active site 889933002630 Zn binding site [ion binding]; other site 889933002631 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 889933002632 Thioredoxin; Region: Thioredoxin_5; pfam13743 889933002633 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 889933002634 apolar tunnel; other site 889933002635 heme binding site [chemical binding]; other site 889933002636 dimerization interface [polypeptide binding]; other site 889933002637 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 889933002638 putative active site [active] 889933002639 putative metal binding residues [ion binding]; other site 889933002640 signature motif; other site 889933002641 putative triphosphate binding site [ion binding]; other site 889933002642 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 889933002643 synthetase active site [active] 889933002644 NTP binding site [chemical binding]; other site 889933002645 metal binding site [ion binding]; metal-binding site 889933002646 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 889933002647 ATP-NAD kinase; Region: NAD_kinase; pfam01513 889933002648 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 889933002649 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 889933002650 active site 889933002651 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 889933002652 MgtE intracellular N domain; Region: MgtE_N; smart00924 889933002653 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 889933002654 Divalent cation transporter; Region: MgtE; pfam01769 889933002655 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 889933002656 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 889933002657 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 889933002658 TrkA-N domain; Region: TrkA_N; pfam02254 889933002659 TrkA-C domain; Region: TrkA_C; pfam02080 889933002660 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 889933002661 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 889933002662 NAD binding site [chemical binding]; other site 889933002663 homotetramer interface [polypeptide binding]; other site 889933002664 homodimer interface [polypeptide binding]; other site 889933002665 substrate binding site [chemical binding]; other site 889933002666 active site 889933002667 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 889933002668 Domain of unknown function DUF20; Region: UPF0118; pfam01594 889933002669 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 889933002670 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 889933002671 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 889933002672 Putative esterase; Region: Esterase; pfam00756 889933002673 hypothetical protein; Provisional; Region: PRK13679 889933002674 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 889933002675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933002676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889933002677 putative substrate translocation pore; other site 889933002678 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 889933002679 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 889933002680 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 889933002681 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 889933002682 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 889933002683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889933002684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889933002685 YueH-like protein; Region: YueH; pfam14166 889933002686 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 889933002687 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 889933002688 G1 box; other site 889933002689 putative GEF interaction site [polypeptide binding]; other site 889933002690 GTP/Mg2+ binding site [chemical binding]; other site 889933002691 Switch I region; other site 889933002692 G2 box; other site 889933002693 G3 box; other site 889933002694 Switch II region; other site 889933002695 G4 box; other site 889933002696 G5 box; other site 889933002697 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 889933002698 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 889933002699 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 889933002700 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 889933002701 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 889933002702 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 889933002703 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 889933002704 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 889933002705 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 889933002706 active site 889933002707 metal binding site [ion binding]; metal-binding site 889933002708 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 889933002709 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 889933002710 IDEAL domain; Region: IDEAL; pfam08858 889933002711 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 889933002712 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 889933002713 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 889933002714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 889933002715 CAAX protease self-immunity; Region: Abi; pfam02517 889933002716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 889933002717 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 889933002718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 889933002719 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 889933002720 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 889933002721 Walker A/P-loop; other site 889933002722 ATP binding site [chemical binding]; other site 889933002723 Q-loop/lid; other site 889933002724 ABC transporter signature motif; other site 889933002725 Walker B; other site 889933002726 D-loop; other site 889933002727 H-loop/switch region; other site 889933002728 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 889933002729 Predicted membrane protein [Function unknown]; Region: COG2259 889933002730 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 889933002731 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 889933002732 siderophore binding site; other site 889933002733 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 889933002734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933002735 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 889933002736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 889933002737 Coenzyme A binding pocket [chemical binding]; other site 889933002738 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 889933002739 UbiA prenyltransferase family; Region: UbiA; pfam01040 889933002740 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 889933002741 isochorismate synthases; Region: isochor_syn; TIGR00543 889933002742 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 889933002743 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 889933002744 dimer interface [polypeptide binding]; other site 889933002745 tetramer interface [polypeptide binding]; other site 889933002746 PYR/PP interface [polypeptide binding]; other site 889933002747 TPP binding site [chemical binding]; other site 889933002748 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 889933002749 TPP-binding site; other site 889933002750 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 889933002751 PGAP1-like protein; Region: PGAP1; pfam07819 889933002752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 889933002753 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 889933002754 substrate binding site [chemical binding]; other site 889933002755 oxyanion hole (OAH) forming residues; other site 889933002756 trimer interface [polypeptide binding]; other site 889933002757 Staphostatin B; Region: Staphostatin_B; pfam09023 889933002758 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 889933002759 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 889933002760 aminotransferase A; Validated; Region: PRK07683 889933002761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889933002762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933002763 homodimer interface [polypeptide binding]; other site 889933002764 catalytic residue [active] 889933002765 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 889933002766 Acyltransferase family; Region: Acyl_transf_3; pfam01757 889933002767 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889933002768 MarR family; Region: MarR; pfam01047 889933002769 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 889933002770 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 889933002771 amidase catalytic site [active] 889933002772 Zn binding residues [ion binding]; other site 889933002773 substrate binding site [chemical binding]; other site 889933002774 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 889933002775 Lysozyme subfamily 2; Region: LYZ2; smart00047 889933002776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933002777 Coenzyme A binding pocket [chemical binding]; other site 889933002778 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 889933002779 Transcriptional regulator [Transcription]; Region: LytR; COG1316 889933002780 Beta-lactamase; Region: Beta-lactamase; pfam00144 889933002781 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 889933002782 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 889933002783 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 889933002784 Subunit I/III interface [polypeptide binding]; other site 889933002785 Subunit III/IV interface [polypeptide binding]; other site 889933002786 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 889933002787 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 889933002788 D-pathway; other site 889933002789 Putative ubiquinol binding site [chemical binding]; other site 889933002790 Low-spin heme (heme b) binding site [chemical binding]; other site 889933002791 Putative water exit pathway; other site 889933002792 Binuclear center (heme o3/CuB) [ion binding]; other site 889933002793 K-pathway; other site 889933002794 Putative proton exit pathway; other site 889933002795 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 889933002796 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 889933002797 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 889933002798 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 889933002799 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 889933002800 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 889933002801 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 889933002802 homodimer interface [polypeptide binding]; other site 889933002803 NADP binding site [chemical binding]; other site 889933002804 substrate binding site [chemical binding]; other site 889933002805 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 889933002806 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 889933002807 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 889933002808 NAD binding site [chemical binding]; other site 889933002809 ATP-grasp domain; Region: ATP-grasp; pfam02222 889933002810 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 889933002811 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 889933002812 ATP binding site [chemical binding]; other site 889933002813 active site 889933002814 substrate binding site [chemical binding]; other site 889933002815 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 889933002816 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 889933002817 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 889933002818 putative active site [active] 889933002819 catalytic triad [active] 889933002820 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 889933002821 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 889933002822 dimerization interface [polypeptide binding]; other site 889933002823 ATP binding site [chemical binding]; other site 889933002824 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 889933002825 dimerization interface [polypeptide binding]; other site 889933002826 ATP binding site [chemical binding]; other site 889933002827 amidophosphoribosyltransferase; Provisional; Region: PRK07272 889933002828 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 889933002829 active site 889933002830 tetramer interface [polypeptide binding]; other site 889933002831 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889933002832 active site 889933002833 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 889933002834 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 889933002835 dimerization interface [polypeptide binding]; other site 889933002836 putative ATP binding site [chemical binding]; other site 889933002837 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 889933002838 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 889933002839 active site 889933002840 substrate binding site [chemical binding]; other site 889933002841 cosubstrate binding site; other site 889933002842 catalytic site [active] 889933002843 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 889933002844 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 889933002845 purine monophosphate binding site [chemical binding]; other site 889933002846 dimer interface [polypeptide binding]; other site 889933002847 putative catalytic residues [active] 889933002848 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 889933002849 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 889933002850 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 889933002851 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 889933002852 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 889933002853 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 889933002854 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 889933002855 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889933002856 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 889933002857 Walker A/P-loop; other site 889933002858 ATP binding site [chemical binding]; other site 889933002859 Q-loop/lid; other site 889933002860 ABC transporter signature motif; other site 889933002861 Walker B; other site 889933002862 D-loop; other site 889933002863 H-loop/switch region; other site 889933002864 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 889933002865 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 889933002866 Walker A/P-loop; other site 889933002867 ATP binding site [chemical binding]; other site 889933002868 Q-loop/lid; other site 889933002869 ABC transporter signature motif; other site 889933002870 Walker B; other site 889933002871 D-loop; other site 889933002872 H-loop/switch region; other site 889933002873 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 889933002874 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 889933002875 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 889933002876 putative RNA binding site [nucleotide binding]; other site 889933002877 Methyltransferase domain; Region: Methyltransf_26; pfam13659 889933002878 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 889933002879 dimerization domain swap beta strand [polypeptide binding]; other site 889933002880 regulatory protein interface [polypeptide binding]; other site 889933002881 active site 889933002882 regulatory phosphorylation site [posttranslational modification]; other site 889933002883 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 889933002884 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 889933002885 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 889933002886 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 889933002887 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 889933002888 catalytic residues [active] 889933002889 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 889933002890 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 889933002891 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 889933002892 TrkA-N domain; Region: TrkA_N; pfam02254 889933002893 TrkA-C domain; Region: TrkA_C; pfam02080 889933002894 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 889933002895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 889933002896 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 889933002897 hypothetical protein; Provisional; Region: PRK13667 889933002898 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 889933002899 active site 889933002900 catalytic residues [active] 889933002901 metal binding site [ion binding]; metal-binding site 889933002902 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 889933002903 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 889933002904 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 889933002905 TPP-binding site [chemical binding]; other site 889933002906 tetramer interface [polypeptide binding]; other site 889933002907 heterodimer interface [polypeptide binding]; other site 889933002908 phosphorylation loop region [posttranslational modification] 889933002909 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 889933002910 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 889933002911 alpha subunit interface [polypeptide binding]; other site 889933002912 TPP binding site [chemical binding]; other site 889933002913 heterodimer interface [polypeptide binding]; other site 889933002914 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 889933002915 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 889933002916 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 889933002917 E3 interaction surface; other site 889933002918 lipoyl attachment site [posttranslational modification]; other site 889933002919 e3 binding domain; Region: E3_binding; pfam02817 889933002920 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 889933002921 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 889933002922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 889933002923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933002924 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889933002925 hypothetical protein; Provisional; Region: PRK04387 889933002926 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 889933002927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889933002928 non-specific DNA binding site [nucleotide binding]; other site 889933002929 salt bridge; other site 889933002930 sequence-specific DNA binding site [nucleotide binding]; other site 889933002931 Cupin domain; Region: Cupin_2; pfam07883 889933002932 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 889933002933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933002934 Walker A/P-loop; other site 889933002935 ATP binding site [chemical binding]; other site 889933002936 Q-loop/lid; other site 889933002937 ABC transporter signature motif; other site 889933002938 Walker B; other site 889933002939 D-loop; other site 889933002940 H-loop/switch region; other site 889933002941 TOBE domain; Region: TOBE_2; pfam08402 889933002942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933002943 putative PBP binding loops; other site 889933002944 dimer interface [polypeptide binding]; other site 889933002945 ABC-ATPase subunit interface; other site 889933002946 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 889933002947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933002948 dimer interface [polypeptide binding]; other site 889933002949 conserved gate region; other site 889933002950 putative PBP binding loops; other site 889933002951 ABC-ATPase subunit interface; other site 889933002952 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 889933002953 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 889933002954 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 889933002955 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 889933002956 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 889933002957 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 889933002958 manganese transport protein MntH; Reviewed; Region: PRK00701 889933002959 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 889933002960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 889933002961 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 889933002962 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 889933002963 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 889933002964 active site 889933002965 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 889933002966 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 889933002967 G1 box; other site 889933002968 putative GEF interaction site [polypeptide binding]; other site 889933002969 GTP/Mg2+ binding site [chemical binding]; other site 889933002970 Switch I region; other site 889933002971 G2 box; other site 889933002972 G3 box; other site 889933002973 Switch II region; other site 889933002974 G4 box; other site 889933002975 G5 box; other site 889933002976 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 889933002977 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 889933002978 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 889933002979 hypothetical protein; Provisional; Region: PRK13666 889933002980 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 889933002981 pyruvate carboxylase; Reviewed; Region: PRK12999 889933002982 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889933002983 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 889933002984 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 889933002985 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 889933002986 active site 889933002987 catalytic residues [active] 889933002988 metal binding site [ion binding]; metal-binding site 889933002989 homodimer binding site [polypeptide binding]; other site 889933002990 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889933002991 carboxyltransferase (CT) interaction site; other site 889933002992 biotinylation site [posttranslational modification]; other site 889933002993 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 889933002994 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 889933002995 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 889933002996 UbiA prenyltransferase family; Region: UbiA; pfam01040 889933002997 Predicted membrane protein [Function unknown]; Region: COG2322 889933002998 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 889933002999 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 889933003000 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 889933003001 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 889933003002 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 889933003003 putative active site [active] 889933003004 catalytic site [active] 889933003005 putative metal binding site [ion binding]; other site 889933003006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 889933003007 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 889933003008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933003009 S-adenosylmethionine binding site [chemical binding]; other site 889933003010 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 889933003011 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 889933003012 active site 889933003013 (T/H)XGH motif; other site 889933003014 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 889933003015 hypothetical protein; Provisional; Region: PRK13670 889933003016 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 889933003017 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 889933003018 heme uptake protein IsdB; Region: IsdB; TIGR03657 889933003019 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933003020 NEAr Transporter domain; Region: NEAT; smart00725 889933003021 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 889933003022 heme-binding site [chemical binding]; other site 889933003023 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 889933003024 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 889933003025 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 889933003026 heme-binding site [chemical binding]; other site 889933003027 heme uptake protein IsdC; Region: IsdC; TIGR03656 889933003028 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 889933003029 heme-binding site [chemical binding]; other site 889933003030 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 889933003031 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889933003032 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 889933003033 intersubunit interface [polypeptide binding]; other site 889933003034 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 889933003035 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933003036 ABC-ATPase subunit interface; other site 889933003037 dimer interface [polypeptide binding]; other site 889933003038 putative PBP binding regions; other site 889933003039 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 889933003040 active site 889933003041 catalytic site [active] 889933003042 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 889933003043 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 889933003044 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 889933003045 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 889933003046 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 889933003047 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 889933003048 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 889933003049 dimer interface [polypeptide binding]; other site 889933003050 motif 1; other site 889933003051 active site 889933003052 motif 2; other site 889933003053 motif 3; other site 889933003054 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 889933003055 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 889933003056 putative tRNA-binding site [nucleotide binding]; other site 889933003057 B3/4 domain; Region: B3_4; pfam03483 889933003058 tRNA synthetase B5 domain; Region: B5; smart00874 889933003059 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 889933003060 dimer interface [polypeptide binding]; other site 889933003061 motif 1; other site 889933003062 motif 3; other site 889933003063 motif 2; other site 889933003064 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 889933003065 ribonuclease HIII; Provisional; Region: PRK00996 889933003066 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 889933003067 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 889933003068 RNA/DNA hybrid binding site [nucleotide binding]; other site 889933003069 active site 889933003070 Cell division protein ZapA; Region: ZapA; cl01146 889933003071 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 889933003072 Colicin V production protein; Region: Colicin_V; pfam02674 889933003073 hypothetical protein; Provisional; Region: PRK08609 889933003074 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 889933003075 active site 889933003076 primer binding site [nucleotide binding]; other site 889933003077 NTP binding site [chemical binding]; other site 889933003078 metal binding triad [ion binding]; metal-binding site 889933003079 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 889933003080 active site 889933003081 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 889933003082 MutS domain III; Region: MutS_III; pfam05192 889933003083 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 889933003084 Walker A/P-loop; other site 889933003085 ATP binding site [chemical binding]; other site 889933003086 Q-loop/lid; other site 889933003087 ABC transporter signature motif; other site 889933003088 Walker B; other site 889933003089 D-loop; other site 889933003090 H-loop/switch region; other site 889933003091 Smr domain; Region: Smr; pfam01713 889933003092 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889933003093 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 889933003094 catalytic residues [active] 889933003095 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 889933003096 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 889933003097 GIY-YIG motif/motif A; other site 889933003098 active site 889933003099 catalytic site [active] 889933003100 putative DNA binding site [nucleotide binding]; other site 889933003101 metal binding site [ion binding]; metal-binding site 889933003102 UvrB/uvrC motif; Region: UVR; pfam02151 889933003103 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 889933003104 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 889933003105 putative Iron-sulfur protein interface [polypeptide binding]; other site 889933003106 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 889933003107 proximal heme binding site [chemical binding]; other site 889933003108 distal heme binding site [chemical binding]; other site 889933003109 putative dimer interface [polypeptide binding]; other site 889933003110 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 889933003111 L-aspartate oxidase; Provisional; Region: PRK06175 889933003112 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 889933003113 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 889933003114 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 889933003115 glutamate racemase; Provisional; Region: PRK00865 889933003116 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 889933003117 active site 889933003118 dimerization interface [polypeptide binding]; other site 889933003119 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 889933003120 active site 889933003121 metal binding site [ion binding]; metal-binding site 889933003122 homotetramer interface [polypeptide binding]; other site 889933003123 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 889933003124 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 889933003125 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 889933003126 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 889933003127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889933003128 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889933003129 beta-channel forming cytolysin; Region: hlyII; TIGR01002 889933003130 superantigen-like protein; Reviewed; Region: PRK13350 889933003131 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933003132 superantigen-like protein; Reviewed; Region: PRK13349 889933003133 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933003134 superantigen-like protein; Reviewed; Region: PRK13043 889933003135 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933003136 ornithine carbamoyltransferase; Provisional; Region: PRK04284 889933003137 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 889933003138 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 889933003139 carbamate kinase; Reviewed; Region: PRK12686 889933003140 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 889933003141 putative substrate binding site [chemical binding]; other site 889933003142 nucleotide binding site [chemical binding]; other site 889933003143 nucleotide binding site [chemical binding]; other site 889933003144 homodimer interface [polypeptide binding]; other site 889933003145 Predicted membrane protein [Function unknown]; Region: COG1288 889933003146 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 889933003147 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 889933003148 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 889933003149 gating phenylalanine in ion channel; other site 889933003150 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 889933003151 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 889933003152 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 889933003153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933003154 motif II; other site 889933003155 hypothetical protein; Provisional; Region: PRK13688 889933003156 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 889933003157 Coenzyme A binding pocket [chemical binding]; other site 889933003158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 889933003159 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 889933003160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 889933003161 MraZ protein; Region: MraZ; pfam02381 889933003162 MraZ protein; Region: MraZ; pfam02381 889933003163 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 889933003164 MraW methylase family; Region: Methyltransf_5; pfam01795 889933003165 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 889933003166 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 889933003167 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 889933003168 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 889933003169 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 889933003170 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 889933003171 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 889933003172 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 889933003173 Mg++ binding site [ion binding]; other site 889933003174 putative catalytic motif [active] 889933003175 putative substrate binding site [chemical binding]; other site 889933003176 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 889933003177 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 889933003178 NAD binding site [chemical binding]; other site 889933003179 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889933003180 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889933003181 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 889933003182 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 889933003183 Cell division protein FtsQ; Region: FtsQ; pfam03799 889933003184 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 889933003185 Cell division protein FtsA; Region: FtsA; smart00842 889933003186 Cell division protein FtsA; Region: FtsA; pfam14450 889933003187 cell division protein FtsZ; Validated; Region: PRK09330 889933003188 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 889933003189 nucleotide binding site [chemical binding]; other site 889933003190 SulA interaction site; other site 889933003191 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 889933003192 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 889933003193 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 889933003194 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889933003195 catalytic residue [active] 889933003196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 889933003197 YGGT family; Region: YGGT; pfam02325 889933003198 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 889933003199 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889933003200 RNA binding surface [nucleotide binding]; other site 889933003201 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 889933003202 DivIVA domain; Region: DivI1A_domain; TIGR03544 889933003203 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 889933003204 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 889933003205 HIGH motif; other site 889933003206 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 889933003207 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 889933003208 active site 889933003209 KMSKS motif; other site 889933003210 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 889933003211 tRNA binding surface [nucleotide binding]; other site 889933003212 anticodon binding site; other site 889933003213 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 889933003214 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 889933003215 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 889933003216 active site 889933003217 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 889933003218 lipoprotein signal peptidase; Provisional; Region: PRK14787 889933003219 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 889933003220 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889933003221 RNA binding surface [nucleotide binding]; other site 889933003222 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 889933003223 active site 889933003224 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 889933003225 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 889933003226 uracil transporter; Provisional; Region: PRK10720 889933003227 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 889933003228 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 889933003229 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 889933003230 dihydroorotase; Validated; Region: pyrC; PRK09357 889933003231 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 889933003232 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 889933003233 active site 889933003234 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 889933003235 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 889933003236 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 889933003237 catalytic site [active] 889933003238 subunit interface [polypeptide binding]; other site 889933003239 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 889933003240 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889933003241 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 889933003242 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 889933003243 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889933003244 ATP-grasp domain; Region: ATP-grasp_4; cl17255 889933003245 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 889933003246 IMP binding site; other site 889933003247 dimer interface [polypeptide binding]; other site 889933003248 interdomain contacts; other site 889933003249 partial ornithine binding site; other site 889933003250 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 889933003251 active site 889933003252 dimer interface [polypeptide binding]; other site 889933003253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889933003254 active site 889933003255 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 889933003256 dimer interface [polypeptide binding]; other site 889933003257 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 889933003258 Domain of unknown function (DUF814); Region: DUF814; pfam05670 889933003259 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 889933003260 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 889933003261 catalytic site [active] 889933003262 G-X2-G-X-G-K; other site 889933003263 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 889933003264 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 889933003265 Flavoprotein; Region: Flavoprotein; pfam02441 889933003266 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 889933003267 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 889933003268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889933003269 ATP binding site [chemical binding]; other site 889933003270 putative Mg++ binding site [ion binding]; other site 889933003271 helicase superfamily c-terminal domain; Region: HELICc; smart00490 889933003272 nucleotide binding region [chemical binding]; other site 889933003273 ATP-binding site [chemical binding]; other site 889933003274 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 889933003275 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 889933003276 active site 889933003277 catalytic residues [active] 889933003278 metal binding site [ion binding]; metal-binding site 889933003279 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 889933003280 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 889933003281 putative active site [active] 889933003282 substrate binding site [chemical binding]; other site 889933003283 putative cosubstrate binding site; other site 889933003284 catalytic site [active] 889933003285 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 889933003286 substrate binding site [chemical binding]; other site 889933003287 16S rRNA methyltransferase B; Provisional; Region: PRK14902 889933003288 NusB family; Region: NusB; pfam01029 889933003289 putative RNA binding site [nucleotide binding]; other site 889933003290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933003291 S-adenosylmethionine binding site [chemical binding]; other site 889933003292 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 889933003293 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889933003294 FeS/SAM binding site; other site 889933003295 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 889933003296 Protein phosphatase 2C; Region: PP2C; pfam00481 889933003297 active site 889933003298 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 889933003299 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 889933003300 active site 889933003301 ATP binding site [chemical binding]; other site 889933003302 substrate binding site [chemical binding]; other site 889933003303 activation loop (A-loop); other site 889933003304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 889933003305 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889933003306 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889933003307 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889933003308 Predicted GTPases [General function prediction only]; Region: COG1162 889933003309 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 889933003310 RNA binding site [nucleotide binding]; other site 889933003311 homodimer interface [polypeptide binding]; other site 889933003312 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 889933003313 GTPase/Zn-binding domain interface [polypeptide binding]; other site 889933003314 GTP/Mg2+ binding site [chemical binding]; other site 889933003315 G4 box; other site 889933003316 G5 box; other site 889933003317 G1 box; other site 889933003318 Switch I region; other site 889933003319 G2 box; other site 889933003320 G3 box; other site 889933003321 Switch II region; other site 889933003322 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 889933003323 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 889933003324 substrate binding site [chemical binding]; other site 889933003325 hexamer interface [polypeptide binding]; other site 889933003326 metal binding site [ion binding]; metal-binding site 889933003327 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 889933003328 Thiamine pyrophosphokinase; Region: TPK; cd07995 889933003329 active site 889933003330 dimerization interface [polypeptide binding]; other site 889933003331 thiamine binding site [chemical binding]; other site 889933003332 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 889933003333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 889933003334 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 889933003335 DAK2 domain; Region: Dak2; pfam02734 889933003336 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 889933003337 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 889933003338 generic binding surface II; other site 889933003339 ssDNA binding site; other site 889933003340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889933003341 ATP binding site [chemical binding]; other site 889933003342 putative Mg++ binding site [ion binding]; other site 889933003343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889933003344 nucleotide binding region [chemical binding]; other site 889933003345 ATP-binding site [chemical binding]; other site 889933003346 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 889933003347 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 889933003348 active site 2 [active] 889933003349 active site 1 [active] 889933003350 putative phosphate acyltransferase; Provisional; Region: PRK05331 889933003351 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 889933003352 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 889933003353 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 889933003354 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 889933003355 NAD(P) binding site [chemical binding]; other site 889933003356 homotetramer interface [polypeptide binding]; other site 889933003357 homodimer interface [polypeptide binding]; other site 889933003358 active site 889933003359 acyl carrier protein; Provisional; Region: acpP; PRK00982 889933003360 ribonuclease III; Reviewed; Region: rnc; PRK00102 889933003361 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 889933003362 dimerization interface [polypeptide binding]; other site 889933003363 active site 889933003364 metal binding site [ion binding]; metal-binding site 889933003365 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 889933003366 dsRNA binding site [nucleotide binding]; other site 889933003367 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 889933003368 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 889933003369 Walker A/P-loop; other site 889933003370 ATP binding site [chemical binding]; other site 889933003371 Q-loop/lid; other site 889933003372 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 889933003373 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 889933003374 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 889933003375 ABC transporter signature motif; other site 889933003376 Walker B; other site 889933003377 D-loop; other site 889933003378 H-loop/switch region; other site 889933003379 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 889933003380 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 889933003381 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 889933003382 P loop; other site 889933003383 GTP binding site [chemical binding]; other site 889933003384 putative DNA-binding protein; Validated; Region: PRK00118 889933003385 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 889933003386 signal recognition particle protein; Provisional; Region: PRK10867 889933003387 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 889933003388 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 889933003389 P loop; other site 889933003390 GTP binding site [chemical binding]; other site 889933003391 Signal peptide binding domain; Region: SRP_SPB; pfam02978 889933003392 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 889933003393 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 889933003394 RimM N-terminal domain; Region: RimM; pfam01782 889933003395 PRC-barrel domain; Region: PRC; pfam05239 889933003396 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 889933003397 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 889933003398 Predicted membrane protein [Function unknown]; Region: COG4485 889933003399 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 889933003400 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 889933003401 GTP/Mg2+ binding site [chemical binding]; other site 889933003402 G4 box; other site 889933003403 G5 box; other site 889933003404 G1 box; other site 889933003405 Switch I region; other site 889933003406 G2 box; other site 889933003407 G3 box; other site 889933003408 Switch II region; other site 889933003409 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 889933003410 RNA/DNA hybrid binding site [nucleotide binding]; other site 889933003411 active site 889933003412 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 889933003413 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 889933003414 CoA-ligase; Region: Ligase_CoA; pfam00549 889933003415 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 889933003416 CoA binding domain; Region: CoA_binding; pfam02629 889933003417 CoA-ligase; Region: Ligase_CoA; pfam00549 889933003418 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 889933003419 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 889933003420 CHAP domain; Region: CHAP; pfam05257 889933003421 FemAB family; Region: FemAB; pfam02388 889933003422 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 889933003423 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 889933003424 DNA protecting protein DprA; Region: dprA; TIGR00732 889933003425 DNA topoisomerase I; Validated; Region: PRK05582 889933003426 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 889933003427 active site 889933003428 interdomain interaction site; other site 889933003429 putative metal-binding site [ion binding]; other site 889933003430 nucleotide binding site [chemical binding]; other site 889933003431 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 889933003432 domain I; other site 889933003433 DNA binding groove [nucleotide binding] 889933003434 phosphate binding site [ion binding]; other site 889933003435 domain II; other site 889933003436 domain III; other site 889933003437 nucleotide binding site [chemical binding]; other site 889933003438 catalytic site [active] 889933003439 domain IV; other site 889933003440 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 889933003441 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 889933003442 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 889933003443 Glucose inhibited division protein A; Region: GIDA; pfam01134 889933003444 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 889933003445 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 889933003446 active site 889933003447 DNA binding site [nucleotide binding] 889933003448 Int/Topo IB signature motif; other site 889933003449 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 889933003450 active site 889933003451 HslU subunit interaction site [polypeptide binding]; other site 889933003452 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 889933003453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933003454 Walker A motif; other site 889933003455 ATP binding site [chemical binding]; other site 889933003456 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 889933003457 Walker B motif; other site 889933003458 arginine finger; other site 889933003459 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 889933003460 transcriptional repressor CodY; Validated; Region: PRK04158 889933003461 CodY GAF-like domain; Region: CodY; pfam06018 889933003462 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 889933003463 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 889933003464 rRNA interaction site [nucleotide binding]; other site 889933003465 S8 interaction site; other site 889933003466 putative laminin-1 binding site; other site 889933003467 elongation factor Ts; Provisional; Region: tsf; PRK09377 889933003468 UBA/TS-N domain; Region: UBA; pfam00627 889933003469 Elongation factor TS; Region: EF_TS; pfam00889 889933003470 Elongation factor TS; Region: EF_TS; pfam00889 889933003471 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 889933003472 putative nucleotide binding site [chemical binding]; other site 889933003473 uridine monophosphate binding site [chemical binding]; other site 889933003474 homohexameric interface [polypeptide binding]; other site 889933003475 ribosome recycling factor; Reviewed; Region: frr; PRK00083 889933003476 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 889933003477 hinge region; other site 889933003478 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 889933003479 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 889933003480 catalytic residue [active] 889933003481 putative FPP diphosphate binding site; other site 889933003482 putative FPP binding hydrophobic cleft; other site 889933003483 dimer interface [polypeptide binding]; other site 889933003484 putative IPP diphosphate binding site; other site 889933003485 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 889933003486 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 889933003487 RIP metalloprotease RseP; Region: TIGR00054 889933003488 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 889933003489 active site 889933003490 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 889933003491 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 889933003492 protein binding site [polypeptide binding]; other site 889933003493 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 889933003494 putative substrate binding region [chemical binding]; other site 889933003495 prolyl-tRNA synthetase; Provisional; Region: PRK09194 889933003496 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 889933003497 dimer interface [polypeptide binding]; other site 889933003498 motif 1; other site 889933003499 active site 889933003500 motif 2; other site 889933003501 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 889933003502 putative deacylase active site [active] 889933003503 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 889933003504 active site 889933003505 motif 3; other site 889933003506 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 889933003507 anticodon binding site; other site 889933003508 DNA polymerase III PolC; Validated; Region: polC; PRK00448 889933003509 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 889933003510 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 889933003511 generic binding surface II; other site 889933003512 generic binding surface I; other site 889933003513 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 889933003514 active site 889933003515 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 889933003516 active site 889933003517 catalytic site [active] 889933003518 substrate binding site [chemical binding]; other site 889933003519 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 889933003520 ribosome maturation protein RimP; Reviewed; Region: PRK00092 889933003521 Sm and related proteins; Region: Sm_like; cl00259 889933003522 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 889933003523 putative oligomer interface [polypeptide binding]; other site 889933003524 putative RNA binding site [nucleotide binding]; other site 889933003525 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 889933003526 NusA N-terminal domain; Region: NusA_N; pfam08529 889933003527 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 889933003528 RNA binding site [nucleotide binding]; other site 889933003529 homodimer interface [polypeptide binding]; other site 889933003530 NusA-like KH domain; Region: KH_5; pfam13184 889933003531 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 889933003532 G-X-X-G motif; other site 889933003533 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 889933003534 putative RNA binding cleft [nucleotide binding]; other site 889933003535 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 889933003536 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 889933003537 translation initiation factor IF-2; Region: IF-2; TIGR00487 889933003538 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 889933003539 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 889933003540 G1 box; other site 889933003541 putative GEF interaction site [polypeptide binding]; other site 889933003542 GTP/Mg2+ binding site [chemical binding]; other site 889933003543 Switch I region; other site 889933003544 G2 box; other site 889933003545 G3 box; other site 889933003546 Switch II region; other site 889933003547 G4 box; other site 889933003548 G5 box; other site 889933003549 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 889933003550 Translation-initiation factor 2; Region: IF-2; pfam11987 889933003551 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 889933003552 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 889933003553 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 889933003554 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 889933003555 RNA binding site [nucleotide binding]; other site 889933003556 active site 889933003557 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 889933003558 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 889933003559 active site 889933003560 Riboflavin kinase; Region: Flavokinase; smart00904 889933003561 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 889933003562 16S/18S rRNA binding site [nucleotide binding]; other site 889933003563 S13e-L30e interaction site [polypeptide binding]; other site 889933003564 25S rRNA binding site [nucleotide binding]; other site 889933003565 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 889933003566 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 889933003567 RNase E interface [polypeptide binding]; other site 889933003568 trimer interface [polypeptide binding]; other site 889933003569 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 889933003570 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 889933003571 RNase E interface [polypeptide binding]; other site 889933003572 trimer interface [polypeptide binding]; other site 889933003573 active site 889933003574 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 889933003575 putative nucleic acid binding region [nucleotide binding]; other site 889933003576 G-X-X-G motif; other site 889933003577 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 889933003578 RNA binding site [nucleotide binding]; other site 889933003579 domain interface; other site 889933003580 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 889933003581 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 889933003582 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 889933003583 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 889933003584 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 889933003585 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 889933003586 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 889933003587 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 889933003588 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889933003589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 889933003590 DNA-binding site [nucleotide binding]; DNA binding site 889933003591 UTRA domain; Region: UTRA; pfam07702 889933003592 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 889933003593 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 889933003594 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 889933003595 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 889933003596 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 889933003597 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 889933003598 classical (c) SDRs; Region: SDR_c; cd05233 889933003599 NAD(P) binding site [chemical binding]; other site 889933003600 active site 889933003601 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 889933003602 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 889933003603 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 889933003604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889933003605 non-specific DNA binding site [nucleotide binding]; other site 889933003606 salt bridge; other site 889933003607 sequence-specific DNA binding site [nucleotide binding]; other site 889933003608 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 889933003609 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 889933003610 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 889933003611 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 889933003612 putative MPT binding site; other site 889933003613 recombinase A; Provisional; Region: recA; PRK09354 889933003614 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 889933003615 hexamer interface [polypeptide binding]; other site 889933003616 Walker A motif; other site 889933003617 ATP binding site [chemical binding]; other site 889933003618 Walker B motif; other site 889933003619 phosphodiesterase; Provisional; Region: PRK12704 889933003620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889933003621 Zn2+ binding site [ion binding]; other site 889933003622 Mg2+ binding site [ion binding]; other site 889933003623 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 889933003624 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 889933003625 putative active site [active] 889933003626 metal binding site [ion binding]; metal-binding site 889933003627 homodimer binding site [polypeptide binding]; other site 889933003628 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 889933003629 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 889933003630 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 889933003631 dimer interface [polypeptide binding]; other site 889933003632 PYR/PP interface [polypeptide binding]; other site 889933003633 TPP binding site [chemical binding]; other site 889933003634 substrate binding site [chemical binding]; other site 889933003635 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 889933003636 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 889933003637 TPP-binding site [chemical binding]; other site 889933003638 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 889933003639 Uncharacterized conserved protein [Function unknown]; Region: COG0011 889933003640 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 889933003641 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 889933003642 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889933003643 FeS/SAM binding site; other site 889933003644 TRAM domain; Region: TRAM; pfam01938 889933003645 Predicted membrane protein [Function unknown]; Region: COG4550 889933003646 Predicted membrane protein [Function unknown]; Region: COG4732 889933003647 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 889933003648 MutS domain I; Region: MutS_I; pfam01624 889933003649 MutS domain II; Region: MutS_II; pfam05188 889933003650 MutS domain III; Region: MutS_III; pfam05192 889933003651 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 889933003652 Walker A/P-loop; other site 889933003653 ATP binding site [chemical binding]; other site 889933003654 Q-loop/lid; other site 889933003655 ABC transporter signature motif; other site 889933003656 Walker B; other site 889933003657 D-loop; other site 889933003658 H-loop/switch region; other site 889933003659 potential frameshift: common BLAST hit: gi|269202913|ref|YP_003282182.1| DNA mismatch repair protein 889933003660 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 889933003661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933003662 ATP binding site [chemical binding]; other site 889933003663 Mg2+ binding site [ion binding]; other site 889933003664 G-X-G motif; other site 889933003665 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 889933003666 ATP binding site [chemical binding]; other site 889933003667 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 889933003668 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 889933003669 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 889933003670 amphipathic channel; other site 889933003671 Asn-Pro-Ala signature motifs; other site 889933003672 glycerol kinase; Provisional; Region: glpK; PRK00047 889933003673 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 889933003674 N- and C-terminal domain interface [polypeptide binding]; other site 889933003675 active site 889933003676 MgATP binding site [chemical binding]; other site 889933003677 catalytic site [active] 889933003678 metal binding site [ion binding]; metal-binding site 889933003679 glycerol binding site [chemical binding]; other site 889933003680 homotetramer interface [polypeptide binding]; other site 889933003681 homodimer interface [polypeptide binding]; other site 889933003682 FBP binding site [chemical binding]; other site 889933003683 protein IIAGlc interface [polypeptide binding]; other site 889933003684 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 889933003685 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 889933003686 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 889933003687 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 889933003688 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 889933003689 bacterial Hfq-like; Region: Hfq; cd01716 889933003690 hexamer interface [polypeptide binding]; other site 889933003691 Sm1 motif; other site 889933003692 RNA binding site [nucleotide binding]; other site 889933003693 Sm2 motif; other site 889933003694 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 889933003695 catalytic residues [active] 889933003696 dimer interface [polypeptide binding]; other site 889933003697 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 889933003698 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 889933003699 HflX GTPase family; Region: HflX; cd01878 889933003700 G1 box; other site 889933003701 GTP/Mg2+ binding site [chemical binding]; other site 889933003702 Switch I region; other site 889933003703 G2 box; other site 889933003704 G3 box; other site 889933003705 Switch II region; other site 889933003706 G4 box; other site 889933003707 G5 box; other site 889933003708 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 889933003709 Aluminium resistance protein; Region: Alum_res; pfam06838 889933003710 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 889933003711 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 889933003712 DNA binding residues [nucleotide binding] 889933003713 putative dimer interface [polypeptide binding]; other site 889933003714 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 889933003715 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 889933003716 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 889933003717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 889933003718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 889933003719 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 889933003720 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 889933003721 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889933003722 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889933003723 catalytic residue [active] 889933003724 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 889933003725 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 889933003726 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 889933003727 putative active site [active] 889933003728 catalytic site [active] 889933003729 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 889933003730 putative active site [active] 889933003731 catalytic site [active] 889933003732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889933003733 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 889933003734 Walker A/P-loop; other site 889933003735 ATP binding site [chemical binding]; other site 889933003736 Q-loop/lid; other site 889933003737 ABC transporter signature motif; other site 889933003738 Walker B; other site 889933003739 D-loop; other site 889933003740 H-loop/switch region; other site 889933003741 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 889933003742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 889933003743 Histidine kinase; Region: HisKA_3; pfam07730 889933003744 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 889933003745 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 889933003746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933003747 active site 889933003748 phosphorylation site [posttranslational modification] 889933003749 intermolecular recognition site; other site 889933003750 dimerization interface [polypeptide binding]; other site 889933003751 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889933003752 DNA binding residues [nucleotide binding] 889933003753 dimerization interface [polypeptide binding]; other site 889933003754 Staphylococcal nuclease homologues; Region: SNc; smart00318 889933003755 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 889933003756 Catalytic site; other site 889933003757 AAA domain; Region: AAA_11; pfam13086 889933003758 aspartate kinase; Reviewed; Region: PRK09034 889933003759 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 889933003760 putative catalytic residues [active] 889933003761 putative nucleotide binding site [chemical binding]; other site 889933003762 putative aspartate binding site [chemical binding]; other site 889933003763 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 889933003764 allosteric regulatory residue; other site 889933003765 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 889933003766 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 889933003767 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 889933003768 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 889933003769 threonine synthase; Reviewed; Region: PRK06721 889933003770 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 889933003771 homodimer interface [polypeptide binding]; other site 889933003772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933003773 catalytic residue [active] 889933003774 homoserine kinase; Provisional; Region: PRK01212 889933003775 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 889933003776 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 889933003777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933003778 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889933003779 active site 889933003780 motif I; other site 889933003781 motif II; other site 889933003782 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 889933003783 lysine transporter; Provisional; Region: PRK10836 889933003784 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 889933003785 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 889933003786 tetramer interface [polypeptide binding]; other site 889933003787 heme binding pocket [chemical binding]; other site 889933003788 NADPH binding site [chemical binding]; other site 889933003789 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 889933003790 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 889933003791 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 889933003792 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 889933003793 active site 889933003794 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 889933003795 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 889933003796 LexA repressor; Validated; Region: PRK00215 889933003797 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889933003798 putative DNA binding site [nucleotide binding]; other site 889933003799 putative Zn2+ binding site [ion binding]; other site 889933003800 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 889933003801 Catalytic site [active] 889933003802 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 889933003803 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 889933003804 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 889933003805 TPP-binding site [chemical binding]; other site 889933003806 dimer interface [polypeptide binding]; other site 889933003807 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 889933003808 PYR/PP interface [polypeptide binding]; other site 889933003809 dimer interface [polypeptide binding]; other site 889933003810 TPP binding site [chemical binding]; other site 889933003811 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 889933003812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 889933003813 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 889933003814 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 889933003815 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 889933003816 active site 889933003817 metal binding site [ion binding]; metal-binding site 889933003818 DNA binding site [nucleotide binding] 889933003819 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 889933003820 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 889933003821 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 889933003822 Walker A/P-loop; other site 889933003823 ATP binding site [chemical binding]; other site 889933003824 Q-loop/lid; other site 889933003825 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 889933003826 ABC transporter signature motif; other site 889933003827 Walker B; other site 889933003828 D-loop; other site 889933003829 H-loop/switch region; other site 889933003830 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 889933003831 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 889933003832 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 889933003833 aconitate hydratase; Validated; Region: PRK09277 889933003834 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 889933003835 substrate binding site [chemical binding]; other site 889933003836 ligand binding site [chemical binding]; other site 889933003837 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 889933003838 substrate binding site [chemical binding]; other site 889933003839 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 889933003840 active site 889933003841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 889933003842 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 889933003843 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 889933003844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933003845 ATP binding site [chemical binding]; other site 889933003846 Mg2+ binding site [ion binding]; other site 889933003847 G-X-G motif; other site 889933003848 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 889933003849 anchoring element; other site 889933003850 dimer interface [polypeptide binding]; other site 889933003851 ATP binding site [chemical binding]; other site 889933003852 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 889933003853 active site 889933003854 putative metal-binding site [ion binding]; other site 889933003855 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 889933003856 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 889933003857 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 889933003858 CAP-like domain; other site 889933003859 active site 889933003860 primary dimer interface [polypeptide binding]; other site 889933003861 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889933003862 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 889933003863 amino acid carrier protein; Region: agcS; TIGR00835 889933003864 CAT RNA binding domain; Region: CAT_RBD; smart01061 889933003865 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 889933003866 PRD domain; Region: PRD; pfam00874 889933003867 PRD domain; Region: PRD; pfam00874 889933003868 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 889933003869 Domain of unknown function DUF20; Region: UPF0118; pfam01594 889933003870 Predicted integral membrane protein [Function unknown]; Region: COG0392 889933003871 Uncharacterized conserved protein [Function unknown]; Region: COG2898 889933003872 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 889933003873 methionine sulfoxide reductase A; Provisional; Region: PRK14054 889933003874 Transcriptional regulator [Transcription]; Region: LytR; COG1316 889933003875 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 889933003876 active site 1 [active] 889933003877 dimer interface [polypeptide binding]; other site 889933003878 hexamer interface [polypeptide binding]; other site 889933003879 active site 2 [active] 889933003880 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 889933003881 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 889933003882 active site 889933003883 DNA binding site [nucleotide binding] 889933003884 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 889933003885 prephenate dehydrogenase; Validated; Region: PRK06545 889933003886 prephenate dehydrogenase; Validated; Region: PRK08507 889933003887 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 889933003888 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 889933003889 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 889933003890 metal binding site [ion binding]; metal-binding site 889933003891 anthranilate synthase component I; Provisional; Region: PRK13567 889933003892 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 889933003893 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 889933003894 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 889933003895 Glutamine amidotransferase class-I; Region: GATase; pfam00117 889933003896 glutamine binding [chemical binding]; other site 889933003897 catalytic triad [active] 889933003898 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 889933003899 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 889933003900 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 889933003901 active site 889933003902 ribulose/triose binding site [chemical binding]; other site 889933003903 phosphate binding site [ion binding]; other site 889933003904 substrate (anthranilate) binding pocket [chemical binding]; other site 889933003905 product (indole) binding pocket [chemical binding]; other site 889933003906 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 889933003907 active site 889933003908 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 889933003909 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 889933003910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933003911 catalytic residue [active] 889933003912 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 889933003913 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 889933003914 substrate binding site [chemical binding]; other site 889933003915 active site 889933003916 catalytic residues [active] 889933003917 heterodimer interface [polypeptide binding]; other site 889933003918 FemAB family; Region: FemAB; pfam02388 889933003919 FlxA-like protein; Region: FlxA; pfam14282 889933003920 FemAB family; Region: FemAB; pfam02388 889933003921 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 889933003922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933003923 active site 889933003924 motif I; other site 889933003925 motif II; other site 889933003926 SWIM zinc finger; Region: SWIM; pfam04434 889933003927 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 889933003928 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 889933003929 Walker A/P-loop; other site 889933003930 ATP binding site [chemical binding]; other site 889933003931 Q-loop/lid; other site 889933003932 ABC transporter signature motif; other site 889933003933 Walker B; other site 889933003934 D-loop; other site 889933003935 H-loop/switch region; other site 889933003936 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 889933003937 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 889933003938 Walker A/P-loop; other site 889933003939 ATP binding site [chemical binding]; other site 889933003940 Q-loop/lid; other site 889933003941 ABC transporter signature motif; other site 889933003942 Walker B; other site 889933003943 D-loop; other site 889933003944 H-loop/switch region; other site 889933003945 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 889933003946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933003947 dimer interface [polypeptide binding]; other site 889933003948 conserved gate region; other site 889933003949 putative PBP binding loops; other site 889933003950 ABC-ATPase subunit interface; other site 889933003951 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889933003952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933003953 dimer interface [polypeptide binding]; other site 889933003954 conserved gate region; other site 889933003955 putative PBP binding loops; other site 889933003956 ABC-ATPase subunit interface; other site 889933003957 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 889933003958 oligoendopeptidase F; Region: pepF; TIGR00181 889933003959 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 889933003960 active site 889933003961 Zn binding site [ion binding]; other site 889933003962 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 889933003963 PhoU domain; Region: PhoU; pfam01895 889933003964 PhoU domain; Region: PhoU; pfam01895 889933003965 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 889933003966 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 889933003967 Walker A/P-loop; other site 889933003968 ATP binding site [chemical binding]; other site 889933003969 Q-loop/lid; other site 889933003970 ABC transporter signature motif; other site 889933003971 Walker B; other site 889933003972 D-loop; other site 889933003973 H-loop/switch region; other site 889933003974 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 889933003975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933003976 dimer interface [polypeptide binding]; other site 889933003977 conserved gate region; other site 889933003978 putative PBP binding loops; other site 889933003979 ABC-ATPase subunit interface; other site 889933003980 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 889933003981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933003982 dimer interface [polypeptide binding]; other site 889933003983 conserved gate region; other site 889933003984 ABC-ATPase subunit interface; other site 889933003985 phosphate binding protein; Region: ptsS_2; TIGR02136 889933003986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 889933003987 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 889933003988 S1 domain; Region: S1_2; pfam13509 889933003989 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 889933003990 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 889933003991 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 889933003992 ABC transporter; Region: ABC_tran_2; pfam12848 889933003993 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 889933003994 aspartate kinase; Reviewed; Region: PRK06635 889933003995 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 889933003996 putative nucleotide binding site [chemical binding]; other site 889933003997 putative catalytic residues [active] 889933003998 putative Mg ion binding site [ion binding]; other site 889933003999 putative aspartate binding site [chemical binding]; other site 889933004000 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 889933004001 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 889933004002 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 889933004003 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 889933004004 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 889933004005 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 889933004006 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 889933004007 dimer interface [polypeptide binding]; other site 889933004008 active site 889933004009 catalytic residue [active] 889933004010 dihydrodipicolinate reductase; Provisional; Region: PRK00048 889933004011 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 889933004012 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 889933004013 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 889933004014 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 889933004015 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 889933004016 active site 889933004017 trimer interface [polypeptide binding]; other site 889933004018 substrate binding site [chemical binding]; other site 889933004019 CoA binding site [chemical binding]; other site 889933004020 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 889933004021 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 889933004022 metal binding site [ion binding]; metal-binding site 889933004023 dimer interface [polypeptide binding]; other site 889933004024 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 889933004025 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 889933004026 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889933004027 catalytic residue [active] 889933004028 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 889933004029 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 889933004030 active site 889933004031 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889933004032 substrate binding site [chemical binding]; other site 889933004033 catalytic residues [active] 889933004034 dimer interface [polypeptide binding]; other site 889933004035 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 889933004036 DNA-binding site [nucleotide binding]; DNA binding site 889933004037 RNA-binding motif; other site 889933004038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 889933004039 acylphosphatase; Provisional; Region: PRK14431 889933004040 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 889933004041 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 889933004042 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 889933004043 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 889933004044 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 889933004045 metal ion-dependent adhesion site (MIDAS); other site 889933004046 MoxR-like ATPases [General function prediction only]; Region: COG0714 889933004047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933004048 Walker A motif; other site 889933004049 ATP binding site [chemical binding]; other site 889933004050 Walker B motif; other site 889933004051 arginine finger; other site 889933004052 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 889933004053 active site 889933004054 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 889933004055 active site 889933004056 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 889933004057 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 889933004058 E3 interaction surface; other site 889933004059 lipoyl attachment site [posttranslational modification]; other site 889933004060 e3 binding domain; Region: E3_binding; pfam02817 889933004061 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 889933004062 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 889933004063 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 889933004064 TPP-binding site [chemical binding]; other site 889933004065 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 889933004066 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 889933004067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 889933004068 HAMP domain; Region: HAMP; pfam00672 889933004069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889933004070 dimer interface [polypeptide binding]; other site 889933004071 phosphorylation site [posttranslational modification] 889933004072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933004073 ATP binding site [chemical binding]; other site 889933004074 Mg2+ binding site [ion binding]; other site 889933004075 G-X-G motif; other site 889933004076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889933004077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933004078 active site 889933004079 phosphorylation site [posttranslational modification] 889933004080 intermolecular recognition site; other site 889933004081 dimerization interface [polypeptide binding]; other site 889933004082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889933004083 DNA binding site [nucleotide binding] 889933004084 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 889933004085 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 889933004086 active site 889933004087 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 889933004088 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 889933004089 active site 889933004090 homodimer interface [polypeptide binding]; other site 889933004091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933004092 Coenzyme A binding pocket [chemical binding]; other site 889933004093 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 889933004094 C-terminal peptidase (prc); Region: prc; TIGR00225 889933004095 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 889933004096 protein binding site [polypeptide binding]; other site 889933004097 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 889933004098 Catalytic dyad [active] 889933004099 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 889933004100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 889933004101 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 889933004102 HPr interaction site; other site 889933004103 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889933004104 active site 889933004105 phosphorylation site [posttranslational modification] 889933004106 methionine sulfoxide reductase B; Provisional; Region: PRK00222 889933004107 SelR domain; Region: SelR; pfam01641 889933004108 methionine sulfoxide reductase A; Provisional; Region: PRK13014 889933004109 EDD domain protein, DegV family; Region: DegV; TIGR00762 889933004110 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 889933004111 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 889933004112 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 889933004113 folate binding site [chemical binding]; other site 889933004114 NADP+ binding site [chemical binding]; other site 889933004115 thymidylate synthase; Region: thym_sym; TIGR03284 889933004116 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 889933004117 dimerization interface [polypeptide binding]; other site 889933004118 active site 889933004119 Disulphide isomerase; Region: Disulph_isomer; pfam06491 889933004120 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 889933004121 Virulence factor; Region: Virulence_fact; pfam13769 889933004122 HEAT repeats; Region: HEAT_2; pfam13646 889933004123 HEAT repeat; Region: HEAT; pfam02985 889933004124 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 889933004125 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 889933004126 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 889933004127 RNA/DNA hybrid binding site [nucleotide binding]; other site 889933004128 active site 889933004129 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933004130 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 889933004131 GA module; Region: GA; smart00844 889933004132 GA module; Region: GA; smart00844 889933004133 GA module; Region: GA; smart00844 889933004134 GA module; Region: GA; smart00844 889933004135 GA module; Region: GA; smart00844 889933004136 GA module; Region: GA; smart00844 889933004137 GA module; Region: GA; smart00844 889933004138 GA module; Region: GA; smart00844 889933004139 GA module; Region: GA; smart00844 889933004140 GA module; Region: GA; smart00844 889933004141 GA module; Region: GA; smart00844 889933004142 GA module; Region: GA; smart00844 889933004143 GA module; Region: GA; smart00844 889933004144 GA module; Region: GA; smart00844 889933004145 GA module; Region: GA; smart00844 889933004146 GA module; Region: GA; smart00844 889933004147 GA module; Region: GA; smart00844 889933004148 GA module; Region: GA; smart00844 889933004149 GA module; Region: GA; smart00844 889933004150 GA module; Region: GA; smart00844 889933004151 GA module; Region: GA; smart00844 889933004152 GA module; Region: GA; smart00844 889933004153 GA module; Region: GA; smart00844 889933004154 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 889933004155 GA module; Region: GA; smart00844 889933004156 GA module; Region: GA; smart00844 889933004157 GA module; Region: GA; pfam01468 889933004158 GA module; Region: GA; smart00844 889933004159 GA module; Region: GA; smart00844 889933004160 GA module; Region: GA; smart00844 889933004161 GA module; Region: GA; smart00844 889933004162 GA module; Region: GA; pfam01468 889933004163 GA module; Region: GA; smart00844 889933004164 GA module; Region: GA; smart00844 889933004165 GA module; Region: GA; smart00844 889933004166 GA module; Region: GA; smart00844 889933004167 GA module; Region: GA; smart00844 889933004168 GA module; Region: GA; smart00844 889933004169 chromosome segregation protein; Provisional; Region: PRK02224 889933004170 GA module; Region: GA; smart00844 889933004171 GA module; Region: GA; smart00844 889933004172 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 889933004173 GA module; Region: GA; pfam01468 889933004174 GA module; Region: GA; smart00844 889933004175 GA module; Region: GA; smart00844 889933004176 GA module; Region: GA; smart00844 889933004177 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933004178 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933004179 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 889933004180 Amino acid permease; Region: AA_permease_2; pfam13520 889933004181 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 889933004182 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 889933004183 tetramer interface [polypeptide binding]; other site 889933004184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933004185 catalytic residue [active] 889933004186 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 889933004187 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 889933004188 hexamer interface [polypeptide binding]; other site 889933004189 ligand binding site [chemical binding]; other site 889933004190 putative active site [active] 889933004191 NAD(P) binding site [chemical binding]; other site 889933004192 5'-3' exonuclease; Region: 53EXOc; smart00475 889933004193 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 889933004194 active site 889933004195 metal binding site 1 [ion binding]; metal-binding site 889933004196 putative 5' ssDNA interaction site; other site 889933004197 metal binding site 3; metal-binding site 889933004198 metal binding site 2 [ion binding]; metal-binding site 889933004199 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 889933004200 putative DNA binding site [nucleotide binding]; other site 889933004201 putative metal binding site [ion binding]; other site 889933004202 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 889933004203 Dynamin family; Region: Dynamin_N; pfam00350 889933004204 G1 box; other site 889933004205 GTP/Mg2+ binding site [chemical binding]; other site 889933004206 G2 box; other site 889933004207 Switch I region; other site 889933004208 G3 box; other site 889933004209 Switch II region; other site 889933004210 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 889933004211 G4 box; other site 889933004212 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 889933004213 Dynamin family; Region: Dynamin_N; pfam00350 889933004214 G1 box; other site 889933004215 GTP/Mg2+ binding site [chemical binding]; other site 889933004216 G2 box; other site 889933004217 Switch I region; other site 889933004218 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 889933004219 G3 box; other site 889933004220 Switch II region; other site 889933004221 GTP/Mg2+ binding site [chemical binding]; other site 889933004222 G4 box; other site 889933004223 G5 box; other site 889933004224 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 889933004225 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 889933004226 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 889933004227 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 889933004228 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 889933004229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 889933004230 cell division protein GpsB; Provisional; Region: PRK14127 889933004231 DivIVA domain; Region: DivI1A_domain; TIGR03544 889933004232 hypothetical protein; Provisional; Region: PRK13660 889933004233 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 889933004234 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 889933004235 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 889933004236 Transglycosylase; Region: Transgly; pfam00912 889933004237 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 889933004238 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 889933004239 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 889933004240 minor groove reading motif; other site 889933004241 helix-hairpin-helix signature motif; other site 889933004242 substrate binding pocket [chemical binding]; other site 889933004243 active site 889933004244 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 889933004245 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 889933004246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 889933004247 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 889933004248 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 889933004249 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 889933004250 putative dimer interface [polypeptide binding]; other site 889933004251 putative anticodon binding site; other site 889933004252 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 889933004253 homodimer interface [polypeptide binding]; other site 889933004254 motif 1; other site 889933004255 motif 2; other site 889933004256 active site 889933004257 motif 3; other site 889933004258 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 889933004259 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 889933004260 active site 889933004261 catalytic site [active] 889933004262 substrate binding site [chemical binding]; other site 889933004263 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 889933004264 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 889933004265 Biotin operon repressor [Transcription]; Region: BirA; COG1654 889933004266 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 889933004267 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 889933004268 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 889933004269 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 889933004270 active site 889933004271 NTP binding site [chemical binding]; other site 889933004272 metal binding triad [ion binding]; metal-binding site 889933004273 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 889933004274 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 889933004275 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 889933004276 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 889933004277 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 889933004278 homodimer interface [polypeptide binding]; other site 889933004279 metal binding site [ion binding]; metal-binding site 889933004280 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 889933004281 Predicted membrane protein [Function unknown]; Region: COG4347 889933004282 Uncharacterized conserved protein [Function unknown]; Region: COG5582 889933004283 UPF0302 domain; Region: UPF0302; pfam08864 889933004284 A short protein domain of unknown function; Region: IDEAL; smart00914 889933004285 TPR repeat; Region: TPR_11; pfam13414 889933004286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 889933004287 binding surface 889933004288 TPR motif; other site 889933004289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 889933004290 TPR motif; other site 889933004291 binding surface 889933004292 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 889933004293 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 889933004294 hinge; other site 889933004295 active site 889933004296 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 889933004297 active site 889933004298 NAD binding site [chemical binding]; other site 889933004299 metal binding site [ion binding]; metal-binding site 889933004300 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 889933004301 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 889933004302 Tetramer interface [polypeptide binding]; other site 889933004303 active site 889933004304 FMN-binding site [chemical binding]; other site 889933004305 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 889933004306 active site 889933004307 multimer interface [polypeptide binding]; other site 889933004308 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 889933004309 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 889933004310 substrate binding pocket [chemical binding]; other site 889933004311 chain length determination region; other site 889933004312 substrate-Mg2+ binding site; other site 889933004313 catalytic residues [active] 889933004314 aspartate-rich region 1; other site 889933004315 active site lid residues [active] 889933004316 aspartate-rich region 2; other site 889933004317 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 889933004318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933004319 S-adenosylmethionine binding site [chemical binding]; other site 889933004320 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 889933004321 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 889933004322 IHF dimer interface [polypeptide binding]; other site 889933004323 IHF - DNA interface [nucleotide binding]; other site 889933004324 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 889933004325 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 889933004326 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 889933004327 GTP-binding protein Der; Reviewed; Region: PRK00093 889933004328 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 889933004329 G1 box; other site 889933004330 GTP/Mg2+ binding site [chemical binding]; other site 889933004331 Switch I region; other site 889933004332 G2 box; other site 889933004333 Switch II region; other site 889933004334 G3 box; other site 889933004335 G4 box; other site 889933004336 G5 box; other site 889933004337 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 889933004338 G1 box; other site 889933004339 GTP/Mg2+ binding site [chemical binding]; other site 889933004340 Switch I region; other site 889933004341 G2 box; other site 889933004342 G3 box; other site 889933004343 Switch II region; other site 889933004344 G4 box; other site 889933004345 G5 box; other site 889933004346 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 889933004347 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 889933004348 RNA binding site [nucleotide binding]; other site 889933004349 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 889933004350 RNA binding site [nucleotide binding]; other site 889933004351 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 889933004352 RNA binding site [nucleotide binding]; other site 889933004353 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 889933004354 RNA binding site [nucleotide binding]; other site 889933004355 cytidylate kinase; Provisional; Region: cmk; PRK00023 889933004356 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 889933004357 CMP-binding site; other site 889933004358 The sites determining sugar specificity; other site 889933004359 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 889933004360 active site 889933004361 homotetramer interface [polypeptide binding]; other site 889933004362 homodimer interface [polypeptide binding]; other site 889933004363 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 889933004364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 889933004365 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933004366 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 889933004367 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 889933004368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889933004369 ATP binding site [chemical binding]; other site 889933004370 putative Mg++ binding site [ion binding]; other site 889933004371 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889933004372 nucleotide binding region [chemical binding]; other site 889933004373 ATP-binding site [chemical binding]; other site 889933004374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 889933004375 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 889933004376 Predicted membrane protein [Function unknown]; Region: COG3601 889933004377 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 889933004378 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 889933004379 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 889933004380 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 889933004381 dimerization interface [polypeptide binding]; other site 889933004382 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 889933004383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889933004384 dimer interface [polypeptide binding]; other site 889933004385 phosphorylation site [posttranslational modification] 889933004386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933004387 ATP binding site [chemical binding]; other site 889933004388 Mg2+ binding site [ion binding]; other site 889933004389 G-X-G motif; other site 889933004390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889933004391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933004392 active site 889933004393 phosphorylation site [posttranslational modification] 889933004394 intermolecular recognition site; other site 889933004395 dimerization interface [polypeptide binding]; other site 889933004396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889933004397 DNA binding site [nucleotide binding] 889933004398 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 889933004399 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889933004400 RNA binding surface [nucleotide binding]; other site 889933004401 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 889933004402 active site 889933004403 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 889933004404 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 889933004405 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 889933004406 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 889933004407 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 889933004408 active site 889933004409 Int/Topo IB signature motif; other site 889933004410 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 889933004411 metal binding site 2 [ion binding]; metal-binding site 889933004412 putative DNA binding helix; other site 889933004413 metal binding site 1 [ion binding]; metal-binding site 889933004414 dimer interface [polypeptide binding]; other site 889933004415 structural Zn2+ binding site [ion binding]; other site 889933004416 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 889933004417 dimer interface [polypeptide binding]; other site 889933004418 ADP-ribose binding site [chemical binding]; other site 889933004419 active site 889933004420 nudix motif; other site 889933004421 metal binding site [ion binding]; metal-binding site 889933004422 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889933004423 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889933004424 active site 889933004425 catalytic tetrad [active] 889933004426 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 889933004427 classical (c) SDRs; Region: SDR_c; cd05233 889933004428 NAD(P) binding site [chemical binding]; other site 889933004429 active site 889933004430 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 889933004431 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 889933004432 ribonuclease Z; Region: RNase_Z; TIGR02651 889933004433 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 889933004434 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 889933004435 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 889933004436 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 889933004437 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 889933004438 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 889933004439 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 889933004440 Ca binding site [ion binding]; other site 889933004441 active site 889933004442 catalytic site [active] 889933004443 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889933004444 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889933004445 DNA binding site [nucleotide binding] 889933004446 domain linker motif; other site 889933004447 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 889933004448 putative ligand binding site [chemical binding]; other site 889933004449 putative dimerization interface [polypeptide binding]; other site 889933004450 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889933004451 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 889933004452 H+ Antiporter protein; Region: 2A0121; TIGR00900 889933004453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933004454 putative substrate translocation pore; other site 889933004455 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 889933004456 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 889933004457 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 889933004458 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 889933004459 peptidase T-like protein; Region: PepT-like; TIGR01883 889933004460 metal binding site [ion binding]; metal-binding site 889933004461 putative dimer interface [polypeptide binding]; other site 889933004462 Predicted membrane protein [Function unknown]; Region: COG4129 889933004463 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 889933004464 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 889933004465 Disulphide isomerase; Region: Disulph_isomer; pfam06491 889933004466 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 889933004467 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 889933004468 E3 interaction surface; other site 889933004469 lipoyl attachment site [posttranslational modification]; other site 889933004470 e3 binding domain; Region: E3_binding; pfam02817 889933004471 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 889933004472 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 889933004473 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 889933004474 alpha subunit interface [polypeptide binding]; other site 889933004475 TPP binding site [chemical binding]; other site 889933004476 heterodimer interface [polypeptide binding]; other site 889933004477 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 889933004478 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 889933004479 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 889933004480 tetramer interface [polypeptide binding]; other site 889933004481 TPP-binding site [chemical binding]; other site 889933004482 heterodimer interface [polypeptide binding]; other site 889933004483 phosphorylation loop region [posttranslational modification] 889933004484 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 889933004485 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 889933004486 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933004487 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889933004488 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 889933004489 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 889933004490 Walker A/P-loop; other site 889933004491 ATP binding site [chemical binding]; other site 889933004492 Q-loop/lid; other site 889933004493 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 889933004494 ABC transporter signature motif; other site 889933004495 Walker B; other site 889933004496 D-loop; other site 889933004497 H-loop/switch region; other site 889933004498 arginine repressor; Provisional; Region: PRK04280 889933004499 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 889933004500 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 889933004501 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 889933004502 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 889933004503 substrate binding pocket [chemical binding]; other site 889933004504 chain length determination region; other site 889933004505 substrate-Mg2+ binding site; other site 889933004506 catalytic residues [active] 889933004507 aspartate-rich region 1; other site 889933004508 active site lid residues [active] 889933004509 aspartate-rich region 2; other site 889933004510 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 889933004511 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 889933004512 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 889933004513 generic binding surface II; other site 889933004514 generic binding surface I; other site 889933004515 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 889933004516 putative RNA binding site [nucleotide binding]; other site 889933004517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 889933004518 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 889933004519 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889933004520 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 889933004521 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 889933004522 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 889933004523 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889933004524 carboxyltransferase (CT) interaction site; other site 889933004525 biotinylation site [posttranslational modification]; other site 889933004526 elongation factor P; Validated; Region: PRK00529 889933004527 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 889933004528 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 889933004529 RNA binding site [nucleotide binding]; other site 889933004530 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 889933004531 RNA binding site [nucleotide binding]; other site 889933004532 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 889933004533 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 889933004534 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 889933004535 active site 889933004536 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 889933004537 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 889933004538 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 889933004539 active site residue [active] 889933004540 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 889933004541 tetramer interface [polypeptide binding]; other site 889933004542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933004543 catalytic residue [active] 889933004544 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 889933004545 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 889933004546 tetramer interface [polypeptide binding]; other site 889933004547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933004548 catalytic residue [active] 889933004549 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 889933004550 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 889933004551 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 889933004552 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 889933004553 ADP binding site [chemical binding]; other site 889933004554 magnesium binding site [ion binding]; other site 889933004555 putative shikimate binding site; other site 889933004556 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 889933004557 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 889933004558 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 889933004559 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 889933004560 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 889933004561 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 889933004562 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 889933004563 Type II/IV secretion system protein; Region: T2SE; pfam00437 889933004564 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 889933004565 Walker A motif; other site 889933004566 ATP binding site [chemical binding]; other site 889933004567 Walker B motif; other site 889933004568 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 889933004569 Uncharacterized conserved protein [Function unknown]; Region: COG0011 889933004570 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 889933004571 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 889933004572 Rhomboid family; Region: Rhomboid; pfam01694 889933004573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 889933004574 binding surface 889933004575 TPR motif; other site 889933004576 Tetratricopeptide repeat; Region: TPR_16; pfam13432 889933004577 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 889933004578 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 889933004579 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 889933004580 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 889933004581 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 889933004582 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 889933004583 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 889933004584 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 889933004585 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 889933004586 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 889933004587 metal binding site 2 [ion binding]; metal-binding site 889933004588 putative DNA binding helix; other site 889933004589 metal binding site 1 [ion binding]; metal-binding site 889933004590 dimer interface [polypeptide binding]; other site 889933004591 structural Zn2+ binding site [ion binding]; other site 889933004592 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 889933004593 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933004594 ABC-ATPase subunit interface; other site 889933004595 dimer interface [polypeptide binding]; other site 889933004596 putative PBP binding regions; other site 889933004597 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 889933004598 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 889933004599 endonuclease IV; Provisional; Region: PRK01060 889933004600 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 889933004601 AP (apurinic/apyrimidinic) site pocket; other site 889933004602 DNA interaction; other site 889933004603 Metal-binding active site; metal-binding site 889933004604 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 889933004605 DEAD-like helicases superfamily; Region: DEXDc; smart00487 889933004606 ATP binding site [chemical binding]; other site 889933004607 putative Mg++ binding site [ion binding]; other site 889933004608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889933004609 nucleotide binding region [chemical binding]; other site 889933004610 ATP-binding site [chemical binding]; other site 889933004611 Uncharacterized conserved protein [Function unknown]; Region: COG0327 889933004612 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 889933004613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 889933004614 Uncharacterized conserved protein [Function unknown]; Region: COG0327 889933004615 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 889933004616 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 889933004617 Family of unknown function (DUF633); Region: DUF633; pfam04816 889933004618 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 889933004619 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 889933004620 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 889933004621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889933004622 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 889933004623 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 889933004624 DNA binding residues [nucleotide binding] 889933004625 DNA primase, catalytic core; Region: dnaG; TIGR01391 889933004626 CHC2 zinc finger; Region: zf-CHC2; pfam01807 889933004627 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 889933004628 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 889933004629 active site 889933004630 metal binding site [ion binding]; metal-binding site 889933004631 interdomain interaction site; other site 889933004632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 889933004633 HTH domain; Region: HTH_11; cl17392 889933004634 FOG: CBS domain [General function prediction only]; Region: COG0517 889933004635 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 889933004636 glycyl-tRNA synthetase; Provisional; Region: PRK04173 889933004637 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 889933004638 motif 1; other site 889933004639 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 889933004640 active site 889933004641 motif 2; other site 889933004642 motif 3; other site 889933004643 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 889933004644 anticodon binding site; other site 889933004645 DNA repair protein RecO; Region: reco; TIGR00613 889933004646 Recombination protein O N terminal; Region: RecO_N; pfam11967 889933004647 Recombination protein O C terminal; Region: RecO_C; pfam02565 889933004648 GTPase Era; Reviewed; Region: era; PRK00089 889933004649 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 889933004650 G1 box; other site 889933004651 GTP/Mg2+ binding site [chemical binding]; other site 889933004652 Switch I region; other site 889933004653 G2 box; other site 889933004654 Switch II region; other site 889933004655 G3 box; other site 889933004656 G4 box; other site 889933004657 G5 box; other site 889933004658 KH domain; Region: KH_2; pfam07650 889933004659 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 889933004660 active site 889933004661 catalytic motif [active] 889933004662 Zn binding site [ion binding]; other site 889933004663 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 889933004664 metal-binding heat shock protein; Provisional; Region: PRK00016 889933004665 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 889933004666 PhoH-like protein; Region: PhoH; pfam02562 889933004667 hypothetical protein; Provisional; Region: PRK13665 889933004668 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 889933004669 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 889933004670 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 889933004671 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 889933004672 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889933004673 FeS/SAM binding site; other site 889933004674 TRAM domain; Region: TRAM; cl01282 889933004675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 889933004676 RNA methyltransferase, RsmE family; Region: TIGR00046 889933004677 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 889933004678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933004679 S-adenosylmethionine binding site [chemical binding]; other site 889933004680 chaperone protein DnaJ; Provisional; Region: PRK14280 889933004681 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 889933004682 HSP70 interaction site [polypeptide binding]; other site 889933004683 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 889933004684 substrate binding site [polypeptide binding]; other site 889933004685 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 889933004686 Zn binding sites [ion binding]; other site 889933004687 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 889933004688 dimer interface [polypeptide binding]; other site 889933004689 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 889933004690 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 889933004691 nucleotide binding site [chemical binding]; other site 889933004692 NEF interaction site [polypeptide binding]; other site 889933004693 SBD interface [polypeptide binding]; other site 889933004694 heat shock protein GrpE; Provisional; Region: PRK14140 889933004695 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 889933004696 dimer interface [polypeptide binding]; other site 889933004697 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 889933004698 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 889933004699 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 889933004700 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 889933004701 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 889933004702 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889933004703 FeS/SAM binding site; other site 889933004704 HemN C-terminal domain; Region: HemN_C; pfam06969 889933004705 GTP-binding protein LepA; Provisional; Region: PRK05433 889933004706 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 889933004707 G1 box; other site 889933004708 putative GEF interaction site [polypeptide binding]; other site 889933004709 GTP/Mg2+ binding site [chemical binding]; other site 889933004710 Switch I region; other site 889933004711 G2 box; other site 889933004712 G3 box; other site 889933004713 Switch II region; other site 889933004714 G4 box; other site 889933004715 G5 box; other site 889933004716 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 889933004717 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 889933004718 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 889933004719 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 889933004720 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 889933004721 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 889933004722 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 889933004723 Competence protein; Region: Competence; pfam03772 889933004724 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 889933004725 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 889933004726 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 889933004727 catalytic motif [active] 889933004728 Zn binding site [ion binding]; other site 889933004729 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 889933004730 Helix-hairpin-helix motif; Region: HHH; pfam00633 889933004731 Methyltransferase domain; Region: Methyltransf_31; pfam13847 889933004732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933004733 S-adenosylmethionine binding site [chemical binding]; other site 889933004734 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 889933004735 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889933004736 Zn2+ binding site [ion binding]; other site 889933004737 Mg2+ binding site [ion binding]; other site 889933004738 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 889933004739 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 889933004740 active site 889933004741 (T/H)XGH motif; other site 889933004742 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 889933004743 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 889933004744 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 889933004745 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 889933004746 shikimate binding site; other site 889933004747 NAD(P) binding site [chemical binding]; other site 889933004748 GTPase YqeH; Provisional; Region: PRK13796 889933004749 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 889933004750 GTP/Mg2+ binding site [chemical binding]; other site 889933004751 G4 box; other site 889933004752 G5 box; other site 889933004753 G1 box; other site 889933004754 Switch I region; other site 889933004755 G2 box; other site 889933004756 G3 box; other site 889933004757 Switch II region; other site 889933004758 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 889933004759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933004760 active site 889933004761 motif I; other site 889933004762 motif II; other site 889933004763 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 889933004764 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 889933004765 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933004766 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933004767 Fic family protein [Function unknown]; Region: COG3177 889933004768 Fic/DOC family; Region: Fic; pfam02661 889933004769 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 889933004770 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 889933004771 putative active site [active] 889933004772 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889933004773 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 889933004774 ATP-grasp domain; Region: ATP-grasp_4; cl17255 889933004775 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 889933004776 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 889933004777 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889933004778 carboxyltransferase (CT) interaction site; other site 889933004779 biotinylation site [posttranslational modification]; other site 889933004780 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 889933004781 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 889933004782 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 889933004783 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 889933004784 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 889933004785 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 889933004786 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 889933004787 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 889933004788 Sugar specificity; other site 889933004789 Pyrimidine base specificity; other site 889933004790 ATP-binding site [chemical binding]; other site 889933004791 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 889933004792 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 889933004793 Peptidase family U32; Region: Peptidase_U32; pfam01136 889933004794 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 889933004795 Peptidase family U32; Region: Peptidase_U32; pfam01136 889933004796 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 889933004797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933004798 S-adenosylmethionine binding site [chemical binding]; other site 889933004799 hypothetical protein; Provisional; Region: PRK13678 889933004800 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 889933004801 hypothetical protein; Provisional; Region: PRK05473 889933004802 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 889933004803 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 889933004804 motif 1; other site 889933004805 active site 889933004806 motif 2; other site 889933004807 motif 3; other site 889933004808 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 889933004809 DHHA1 domain; Region: DHHA1; pfam02272 889933004810 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 889933004811 AAA domain; Region: AAA_30; pfam13604 889933004812 Family description; Region: UvrD_C_2; pfam13538 889933004813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 889933004814 binding surface 889933004815 TPR motif; other site 889933004816 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 889933004817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 889933004818 binding surface 889933004819 TPR motif; other site 889933004820 TPR repeat; Region: TPR_11; pfam13414 889933004821 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 889933004822 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 889933004823 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 889933004824 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 889933004825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889933004826 catalytic residue [active] 889933004827 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 889933004828 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 889933004829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 889933004830 Predicted transcriptional regulator [Transcription]; Region: COG1959 889933004831 Transcriptional regulator; Region: Rrf2; pfam02082 889933004832 recombination factor protein RarA; Reviewed; Region: PRK13342 889933004833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933004834 Walker A motif; other site 889933004835 ATP binding site [chemical binding]; other site 889933004836 Walker B motif; other site 889933004837 arginine finger; other site 889933004838 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 889933004839 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 889933004840 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 889933004841 putative ATP binding site [chemical binding]; other site 889933004842 putative substrate interface [chemical binding]; other site 889933004843 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 889933004844 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 889933004845 dimer interface [polypeptide binding]; other site 889933004846 anticodon binding site; other site 889933004847 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 889933004848 homodimer interface [polypeptide binding]; other site 889933004849 motif 1; other site 889933004850 active site 889933004851 motif 2; other site 889933004852 GAD domain; Region: GAD; pfam02938 889933004853 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 889933004854 motif 3; other site 889933004855 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 889933004856 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 889933004857 dimer interface [polypeptide binding]; other site 889933004858 motif 1; other site 889933004859 active site 889933004860 motif 2; other site 889933004861 motif 3; other site 889933004862 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 889933004863 anticodon binding site; other site 889933004864 Bacterial SH3 domain homologues; Region: SH3b; smart00287 889933004865 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 889933004866 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 889933004867 active site 889933004868 metal binding site [ion binding]; metal-binding site 889933004869 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 889933004870 putative active site [active] 889933004871 dimerization interface [polypeptide binding]; other site 889933004872 putative tRNAtyr binding site [nucleotide binding]; other site 889933004873 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 889933004874 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889933004875 Zn2+ binding site [ion binding]; other site 889933004876 Mg2+ binding site [ion binding]; other site 889933004877 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 889933004878 synthetase active site [active] 889933004879 NTP binding site [chemical binding]; other site 889933004880 metal binding site [ion binding]; metal-binding site 889933004881 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 889933004882 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 889933004883 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889933004884 active site 889933004885 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 889933004886 DHH family; Region: DHH; pfam01368 889933004887 DHHA1 domain; Region: DHHA1; pfam02272 889933004888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 889933004889 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 889933004890 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 889933004891 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 889933004892 Protein export membrane protein; Region: SecD_SecF; pfam02355 889933004893 Preprotein translocase subunit; Region: YajC; pfam02699 889933004894 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 889933004895 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 889933004896 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 889933004897 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 889933004898 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 889933004899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933004900 Walker A motif; other site 889933004901 ATP binding site [chemical binding]; other site 889933004902 Walker B motif; other site 889933004903 arginine finger; other site 889933004904 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 889933004905 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 889933004906 RuvA N terminal domain; Region: RuvA_N; pfam01330 889933004907 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 889933004908 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 889933004909 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 889933004910 GTPase CgtA; Reviewed; Region: obgE; PRK12297 889933004911 GTP1/OBG; Region: GTP1_OBG; pfam01018 889933004912 Obg GTPase; Region: Obg; cd01898 889933004913 G1 box; other site 889933004914 GTP/Mg2+ binding site [chemical binding]; other site 889933004915 Switch I region; other site 889933004916 G2 box; other site 889933004917 G3 box; other site 889933004918 Switch II region; other site 889933004919 G4 box; other site 889933004920 G5 box; other site 889933004921 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 889933004922 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 889933004923 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 889933004924 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 889933004925 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 889933004926 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 889933004927 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 889933004928 rod shape-determining protein MreC; Region: MreC; pfam04085 889933004929 hypothetical protein; Reviewed; Region: PRK00024 889933004930 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 889933004931 MPN+ (JAMM) motif; other site 889933004932 Zinc-binding site [ion binding]; other site 889933004933 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 889933004934 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 889933004935 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 889933004936 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 889933004937 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889933004938 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889933004939 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 889933004940 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889933004941 active site 889933004942 HIGH motif; other site 889933004943 nucleotide binding site [chemical binding]; other site 889933004944 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 889933004945 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 889933004946 active site 889933004947 KMSKS motif; other site 889933004948 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 889933004949 tRNA binding surface [nucleotide binding]; other site 889933004950 anticodon binding site; other site 889933004951 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 889933004952 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 889933004953 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 889933004954 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 889933004955 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889933004956 inhibitor-cofactor binding pocket; inhibition site 889933004957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933004958 catalytic residue [active] 889933004959 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 889933004960 dimer interface [polypeptide binding]; other site 889933004961 active site 889933004962 Schiff base residues; other site 889933004963 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 889933004964 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 889933004965 active site 889933004966 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 889933004967 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 889933004968 domain interfaces; other site 889933004969 active site 889933004970 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 889933004971 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 889933004972 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 889933004973 tRNA; other site 889933004974 putative tRNA binding site [nucleotide binding]; other site 889933004975 putative NADP binding site [chemical binding]; other site 889933004976 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 889933004977 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 889933004978 G1 box; other site 889933004979 GTP/Mg2+ binding site [chemical binding]; other site 889933004980 Switch I region; other site 889933004981 G2 box; other site 889933004982 G3 box; other site 889933004983 Switch II region; other site 889933004984 G4 box; other site 889933004985 G5 box; other site 889933004986 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 889933004987 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 889933004988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933004989 Walker A motif; other site 889933004990 ATP binding site [chemical binding]; other site 889933004991 Walker B motif; other site 889933004992 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 889933004993 trigger factor; Provisional; Region: tig; PRK01490 889933004994 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 889933004995 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 889933004996 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 889933004997 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 889933004998 23S rRNA binding site [nucleotide binding]; other site 889933004999 L21 binding site [polypeptide binding]; other site 889933005000 L13 binding site [polypeptide binding]; other site 889933005001 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 889933005002 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 889933005003 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 889933005004 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 889933005005 lysine transporter; Provisional; Region: PRK10836 889933005006 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 889933005007 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 889933005008 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 889933005009 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 889933005010 active site 889933005011 dimer interface [polypeptide binding]; other site 889933005012 motif 1; other site 889933005013 motif 2; other site 889933005014 motif 3; other site 889933005015 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 889933005016 anticodon binding site; other site 889933005017 primosomal protein DnaI; Reviewed; Region: PRK08939 889933005018 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 889933005019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933005020 Walker A motif; other site 889933005021 ATP binding site [chemical binding]; other site 889933005022 Walker B motif; other site 889933005023 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 889933005024 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 889933005025 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 889933005026 ATP cone domain; Region: ATP-cone; pfam03477 889933005027 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 889933005028 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 889933005029 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 889933005030 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 889933005031 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 889933005032 CoA-binding site [chemical binding]; other site 889933005033 ATP-binding [chemical binding]; other site 889933005034 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 889933005035 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 889933005036 DNA binding site [nucleotide binding] 889933005037 catalytic residue [active] 889933005038 H2TH interface [polypeptide binding]; other site 889933005039 putative catalytic residues [active] 889933005040 turnover-facilitating residue; other site 889933005041 intercalation triad [nucleotide binding]; other site 889933005042 8OG recognition residue [nucleotide binding]; other site 889933005043 putative reading head residues; other site 889933005044 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 889933005045 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 889933005046 DNA polymerase I; Provisional; Region: PRK05755 889933005047 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 889933005048 active site 889933005049 metal binding site 1 [ion binding]; metal-binding site 889933005050 putative 5' ssDNA interaction site; other site 889933005051 metal binding site 3; metal-binding site 889933005052 metal binding site 2 [ion binding]; metal-binding site 889933005053 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 889933005054 putative DNA binding site [nucleotide binding]; other site 889933005055 putative metal binding site [ion binding]; other site 889933005056 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 889933005057 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 889933005058 active site 889933005059 DNA binding site [nucleotide binding] 889933005060 catalytic site [active] 889933005061 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 889933005062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889933005063 dimer interface [polypeptide binding]; other site 889933005064 phosphorylation site [posttranslational modification] 889933005065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933005066 ATP binding site [chemical binding]; other site 889933005067 Mg2+ binding site [ion binding]; other site 889933005068 G-X-G motif; other site 889933005069 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889933005070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933005071 active site 889933005072 phosphorylation site [posttranslational modification] 889933005073 intermolecular recognition site; other site 889933005074 dimerization interface [polypeptide binding]; other site 889933005075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889933005076 DNA binding site [nucleotide binding] 889933005077 isocitrate dehydrogenase; Reviewed; Region: PRK07006 889933005078 isocitrate dehydrogenase; Validated; Region: PRK07362 889933005079 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 889933005080 dimer interface [polypeptide binding]; other site 889933005081 Citrate synthase; Region: Citrate_synt; pfam00285 889933005082 active site 889933005083 citrylCoA binding site [chemical binding]; other site 889933005084 oxalacetate/citrate binding site [chemical binding]; other site 889933005085 coenzyme A binding site [chemical binding]; other site 889933005086 catalytic triad [active] 889933005087 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 889933005088 pyruvate kinase; Provisional; Region: PRK06354 889933005089 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 889933005090 domain interfaces; other site 889933005091 active site 889933005092 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 889933005093 6-phosphofructokinase; Provisional; Region: PRK03202 889933005094 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 889933005095 active site 889933005096 ADP/pyrophosphate binding site [chemical binding]; other site 889933005097 dimerization interface [polypeptide binding]; other site 889933005098 allosteric effector site; other site 889933005099 fructose-1,6-bisphosphate binding site; other site 889933005100 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 889933005101 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 889933005102 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 889933005103 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 889933005104 Malic enzyme, N-terminal domain; Region: malic; pfam00390 889933005105 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 889933005106 putative NAD(P) binding site [chemical binding]; other site 889933005107 Malic enzyme, N-terminal domain; Region: malic; pfam00390 889933005108 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 889933005109 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 889933005110 active site 889933005111 PHP Thumb interface [polypeptide binding]; other site 889933005112 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 889933005113 generic binding surface I; other site 889933005114 generic binding surface II; other site 889933005115 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 889933005116 DHH family; Region: DHH; pfam01368 889933005117 DHHA1 domain; Region: DHHA1; pfam02272 889933005118 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 889933005119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 889933005120 DNA-binding site [nucleotide binding]; DNA binding site 889933005121 DRTGG domain; Region: DRTGG; pfam07085 889933005122 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 889933005123 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 889933005124 active site 2 [active] 889933005125 active site 1 [active] 889933005126 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889933005127 Ligand Binding Site [chemical binding]; other site 889933005128 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 889933005129 metal-dependent hydrolase; Provisional; Region: PRK00685 889933005130 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 889933005131 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 889933005132 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 889933005133 active site 889933005134 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 889933005135 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 889933005136 hexamer interface [polypeptide binding]; other site 889933005137 ligand binding site [chemical binding]; other site 889933005138 putative active site [active] 889933005139 NAD(P) binding site [chemical binding]; other site 889933005140 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889933005141 Ligand Binding Site [chemical binding]; other site 889933005142 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 889933005143 propionate/acetate kinase; Provisional; Region: PRK12379 889933005144 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 889933005145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933005146 S-adenosylmethionine binding site [chemical binding]; other site 889933005147 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 889933005148 dimer interface [polypeptide binding]; other site 889933005149 catalytic triad [active] 889933005150 peroxidatic and resolving cysteines [active] 889933005151 hypothetical protein; Provisional; Region: PRK10621 889933005152 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 889933005153 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 889933005154 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 889933005155 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 889933005156 Ligand Binding Site [chemical binding]; other site 889933005157 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 889933005158 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 889933005159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889933005160 catalytic residue [active] 889933005161 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 889933005162 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 889933005163 GAF domain; Region: GAF_2; pfam13185 889933005164 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 889933005165 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 889933005166 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889933005167 RNA binding surface [nucleotide binding]; other site 889933005168 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 889933005169 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 889933005170 active site 889933005171 catalytic site [active] 889933005172 OsmC-like protein; Region: OsmC; cl00767 889933005173 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 889933005174 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889933005175 catalytic residue [active] 889933005176 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 889933005177 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 889933005178 ligand binding site [chemical binding]; other site 889933005179 NAD binding site [chemical binding]; other site 889933005180 dimerization interface [polypeptide binding]; other site 889933005181 catalytic site [active] 889933005182 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 889933005183 putative L-serine binding site [chemical binding]; other site 889933005184 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 889933005185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933005186 motif II; other site 889933005187 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 889933005188 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 889933005189 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889933005190 active site turn [active] 889933005191 phosphorylation site [posttranslational modification] 889933005192 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 889933005193 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 889933005194 putative acyl-acceptor binding pocket; other site 889933005195 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 889933005196 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 889933005197 protein binding site [polypeptide binding]; other site 889933005198 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 889933005199 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 889933005200 active site 889933005201 HIGH motif; other site 889933005202 dimer interface [polypeptide binding]; other site 889933005203 KMSKS motif; other site 889933005204 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889933005205 RNA binding surface [nucleotide binding]; other site 889933005206 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 889933005207 Transglycosylase; Region: Transgly; pfam00912 889933005208 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 889933005209 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 889933005210 NEAr Transporter domain; Region: NEAT; smart00725 889933005211 NEAr Transporter domain; Region: NEAT; smart00725 889933005212 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 889933005213 heme-binding site [chemical binding]; other site 889933005214 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 889933005215 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 889933005216 Potassium binding sites [ion binding]; other site 889933005217 Cesium cation binding sites [ion binding]; other site 889933005218 acetyl-CoA synthetase; Provisional; Region: PRK04319 889933005219 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 889933005220 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 889933005221 active site 889933005222 acyl-activating enzyme (AAE) consensus motif; other site 889933005223 putative CoA binding site [chemical binding]; other site 889933005224 AMP binding site [chemical binding]; other site 889933005225 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 889933005226 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 889933005227 active site 889933005228 Zn binding site [ion binding]; other site 889933005229 catabolite control protein A; Region: ccpA; TIGR01481 889933005230 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889933005231 DNA binding site [nucleotide binding] 889933005232 domain linker motif; other site 889933005233 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 889933005234 dimerization interface [polypeptide binding]; other site 889933005235 effector binding site; other site 889933005236 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 889933005237 Chorismate mutase type II; Region: CM_2; cl00693 889933005238 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 889933005239 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 889933005240 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 889933005241 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 889933005242 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889933005243 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889933005244 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 889933005245 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 889933005246 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 889933005247 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 889933005248 putative tRNA-binding site [nucleotide binding]; other site 889933005249 hypothetical protein; Provisional; Region: PRK13668 889933005250 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889933005251 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 889933005252 catalytic residues [active] 889933005253 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 889933005254 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 889933005255 oligomer interface [polypeptide binding]; other site 889933005256 active site 889933005257 metal binding site [ion binding]; metal-binding site 889933005258 Predicted small secreted protein [Function unknown]; Region: COG5584 889933005259 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 889933005260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933005261 S-adenosylmethionine binding site [chemical binding]; other site 889933005262 Phosphotransferase enzyme family; Region: APH; pfam01636 889933005263 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 889933005264 active site 889933005265 substrate binding site [chemical binding]; other site 889933005266 ATP binding site [chemical binding]; other site 889933005267 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 889933005268 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 889933005269 homodimer interface [polypeptide binding]; other site 889933005270 substrate-cofactor binding pocket; other site 889933005271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933005272 catalytic residue [active] 889933005273 dipeptidase PepV; Reviewed; Region: PRK07318 889933005274 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 889933005275 active site 889933005276 metal binding site [ion binding]; metal-binding site 889933005277 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 889933005278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889933005279 RNA binding surface [nucleotide binding]; other site 889933005280 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 889933005281 active site 889933005282 uracil binding [chemical binding]; other site 889933005283 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 889933005284 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 889933005285 HI0933-like protein; Region: HI0933_like; pfam03486 889933005286 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933005287 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 889933005288 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005289 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005290 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005291 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005292 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005293 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005294 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005295 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005296 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005297 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005298 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005299 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005300 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005301 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005302 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933005303 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 889933005304 active site residue [active] 889933005305 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 889933005306 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 889933005307 HIGH motif; other site 889933005308 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 889933005309 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 889933005310 active site 889933005311 KMSKS motif; other site 889933005312 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 889933005313 tRNA binding surface [nucleotide binding]; other site 889933005314 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889933005315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933005316 putative substrate translocation pore; other site 889933005317 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 889933005318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933005319 S-adenosylmethionine binding site [chemical binding]; other site 889933005320 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933005321 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 889933005322 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 889933005323 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 889933005324 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 889933005325 homopentamer interface [polypeptide binding]; other site 889933005326 active site 889933005327 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 889933005328 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 889933005329 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 889933005330 dimerization interface [polypeptide binding]; other site 889933005331 active site 889933005332 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 889933005333 Lumazine binding domain; Region: Lum_binding; pfam00677 889933005334 Lumazine binding domain; Region: Lum_binding; pfam00677 889933005335 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 889933005336 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 889933005337 catalytic motif [active] 889933005338 Zn binding site [ion binding]; other site 889933005339 RibD C-terminal domain; Region: RibD_C; cl17279 889933005340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 889933005341 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 889933005342 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 889933005343 arsenical pump membrane protein; Provisional; Region: PRK15445 889933005344 transmembrane helices; other site 889933005345 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 889933005346 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 889933005347 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 889933005348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 889933005349 DNA binding residues [nucleotide binding] 889933005350 CAAX protease self-immunity; Region: Abi; pfam02517 889933005351 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 889933005352 active site 889933005353 intersubunit interactions; other site 889933005354 catalytic residue [active] 889933005355 camphor resistance protein CrcB; Provisional; Region: PRK14201 889933005356 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 889933005357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 889933005358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 889933005359 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 889933005360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889933005361 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889933005362 active site 889933005363 catalytic tetrad [active] 889933005364 S-adenosylmethionine synthetase; Validated; Region: PRK05250 889933005365 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 889933005366 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 889933005367 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 889933005368 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 889933005369 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 889933005370 active site 889933005371 substrate-binding site [chemical binding]; other site 889933005372 metal-binding site [ion binding] 889933005373 ATP binding site [chemical binding]; other site 889933005374 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 889933005375 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 889933005376 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 889933005377 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 889933005378 nudix motif; other site 889933005379 Haemolytic domain; Region: Haemolytic; pfam01809 889933005380 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 889933005381 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 889933005382 metal binding site [ion binding]; metal-binding site 889933005383 substrate binding pocket [chemical binding]; other site 889933005384 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 889933005385 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 889933005386 acyl-activating enzyme (AAE) consensus motif; other site 889933005387 putative AMP binding site [chemical binding]; other site 889933005388 putative active site [active] 889933005389 putative CoA binding site [chemical binding]; other site 889933005390 Excalibur calcium-binding domain; Region: Excalibur; smart00894 889933005391 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 889933005392 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 889933005393 Integrase core domain; Region: rve; pfam00665 889933005394 DDE domain; Region: DDE_Tnp_IS240; pfam13610 889933005395 Integrase core domain; Region: rve_3; pfam13683 889933005396 Winged helix-turn helix; Region: HTH_29; pfam13551 889933005397 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 889933005398 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 889933005399 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 889933005400 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 889933005401 HsdM N-terminal domain; Region: HsdM_N; pfam12161 889933005402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933005403 S-adenosylmethionine binding site [chemical binding]; other site 889933005404 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 889933005405 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 889933005406 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 889933005407 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 889933005408 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 889933005409 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 889933005410 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 889933005411 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 889933005412 beta-channel forming cytolysin; Region: hlyII; TIGR01002 889933005413 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 889933005414 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 889933005415 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 889933005416 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 889933005417 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 889933005418 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933005419 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933005420 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933005421 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933005422 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933005423 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933005424 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933005425 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933005426 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933005427 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933005428 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933005429 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933005430 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 889933005431 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 889933005432 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 889933005433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 889933005434 ferrochelatase; Provisional; Region: PRK12435 889933005435 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 889933005436 C-terminal domain interface [polypeptide binding]; other site 889933005437 active site 889933005438 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 889933005439 active site 889933005440 N-terminal domain interface [polypeptide binding]; other site 889933005441 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 889933005442 substrate binding site [chemical binding]; other site 889933005443 active site 889933005444 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 889933005445 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 889933005446 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 889933005447 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 889933005448 Walker A/P-loop; other site 889933005449 ATP binding site [chemical binding]; other site 889933005450 Q-loop/lid; other site 889933005451 ABC transporter signature motif; other site 889933005452 Walker B; other site 889933005453 D-loop; other site 889933005454 H-loop/switch region; other site 889933005455 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 889933005456 HIT family signature motif; other site 889933005457 catalytic residue [active] 889933005458 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 889933005459 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 889933005460 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 889933005461 SurA N-terminal domain; Region: SurA_N_3; cl07813 889933005462 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 889933005463 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 889933005464 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 889933005465 generic binding surface II; other site 889933005466 generic binding surface I; other site 889933005467 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889933005468 Zn2+ binding site [ion binding]; other site 889933005469 Mg2+ binding site [ion binding]; other site 889933005470 Uncharacterized conserved protein [Function unknown]; Region: COG4717 889933005471 P-loop containing region of AAA domain; Region: AAA_29; cl17516 889933005472 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 889933005473 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 889933005474 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 889933005475 active site 889933005476 metal binding site [ion binding]; metal-binding site 889933005477 DNA binding site [nucleotide binding] 889933005478 hypothetical protein; Provisional; Region: PRK13676 889933005479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 889933005480 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 889933005481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889933005482 non-specific DNA binding site [nucleotide binding]; other site 889933005483 salt bridge; other site 889933005484 sequence-specific DNA binding site [nucleotide binding]; other site 889933005485 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 889933005486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933005487 active site 889933005488 phosphorylation site [posttranslational modification] 889933005489 intermolecular recognition site; other site 889933005490 dimerization interface [polypeptide binding]; other site 889933005491 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889933005492 DNA binding residues [nucleotide binding] 889933005493 dimerization interface [polypeptide binding]; other site 889933005494 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 889933005495 GAF domain; Region: GAF_3; pfam13492 889933005496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 889933005497 Histidine kinase; Region: HisKA_3; pfam07730 889933005498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933005499 ATP binding site [chemical binding]; other site 889933005500 Mg2+ binding site [ion binding]; other site 889933005501 G-X-G motif; other site 889933005502 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 889933005503 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 889933005504 active site 889933005505 fumarate hydratase; Reviewed; Region: fumC; PRK00485 889933005506 Class II fumarases; Region: Fumarase_classII; cd01362 889933005507 active site 889933005508 tetramer interface [polypeptide binding]; other site 889933005509 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 889933005510 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 889933005511 active site 889933005512 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 889933005513 epoxyqueuosine reductase; Region: TIGR00276 889933005514 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 889933005515 HEAT repeats; Region: HEAT_2; pfam13646 889933005516 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 889933005517 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 889933005518 Walker A/P-loop; other site 889933005519 ATP binding site [chemical binding]; other site 889933005520 Q-loop/lid; other site 889933005521 ABC transporter signature motif; other site 889933005522 Walker B; other site 889933005523 D-loop; other site 889933005524 H-loop/switch region; other site 889933005525 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889933005526 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 889933005527 substrate binding pocket [chemical binding]; other site 889933005528 membrane-bound complex binding site; other site 889933005529 hinge residues; other site 889933005530 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 889933005531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933005532 dimer interface [polypeptide binding]; other site 889933005533 conserved gate region; other site 889933005534 putative PBP binding loops; other site 889933005535 ABC-ATPase subunit interface; other site 889933005536 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 889933005537 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 889933005538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889933005539 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889933005540 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 889933005541 metal binding site 2 [ion binding]; metal-binding site 889933005542 putative DNA binding helix; other site 889933005543 metal binding site 1 [ion binding]; metal-binding site 889933005544 dimer interface [polypeptide binding]; other site 889933005545 structural Zn2+ binding site [ion binding]; other site 889933005546 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 889933005547 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 889933005548 putative ligand binding site [chemical binding]; other site 889933005549 NAD binding site [chemical binding]; other site 889933005550 catalytic site [active] 889933005551 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 889933005552 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 889933005553 catalytic triad [active] 889933005554 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 889933005555 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889933005556 inhibitor-cofactor binding pocket; inhibition site 889933005557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933005558 catalytic residue [active] 889933005559 Predicted membrane protein [Function unknown]; Region: COG4129 889933005560 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 889933005561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889933005562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 889933005563 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 889933005564 Walker A/P-loop; other site 889933005565 ATP binding site [chemical binding]; other site 889933005566 Q-loop/lid; other site 889933005567 ABC transporter signature motif; other site 889933005568 Walker B; other site 889933005569 D-loop; other site 889933005570 H-loop/switch region; other site 889933005571 hypothetical protein; Provisional; Region: PRK13662 889933005572 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 889933005573 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 889933005574 minor groove reading motif; other site 889933005575 helix-hairpin-helix signature motif; other site 889933005576 substrate binding pocket [chemical binding]; other site 889933005577 active site 889933005578 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 889933005579 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 889933005580 DNA binding and oxoG recognition site [nucleotide binding] 889933005581 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 889933005582 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 889933005583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933005584 Walker A/P-loop; other site 889933005585 ATP binding site [chemical binding]; other site 889933005586 Q-loop/lid; other site 889933005587 ABC transporter signature motif; other site 889933005588 Walker B; other site 889933005589 H-loop/switch region; other site 889933005590 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 889933005591 recombination regulator RecX; Provisional; Region: recX; PRK14135 889933005592 glycosyltransferase; Provisional; Region: PRK13481 889933005593 Transglycosylase; Region: Transgly; pfam00912 889933005594 intracellular protease, PfpI family; Region: PfpI; TIGR01382 889933005595 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 889933005596 proposed catalytic triad [active] 889933005597 conserved cys residue [active] 889933005598 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 889933005599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889933005600 FeS/SAM binding site; other site 889933005601 YfkB-like domain; Region: YfkB; pfam08756 889933005602 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 889933005603 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 889933005604 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 889933005605 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 889933005606 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 889933005607 Low molecular weight phosphatase family; Region: LMWPc; cd00115 889933005608 active site 889933005609 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 889933005610 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 889933005611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933005612 active site 889933005613 phosphorylation site [posttranslational modification] 889933005614 intermolecular recognition site; other site 889933005615 dimerization interface [polypeptide binding]; other site 889933005616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889933005617 DNA binding residues [nucleotide binding] 889933005618 dimerization interface [polypeptide binding]; other site 889933005619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 889933005620 Histidine kinase; Region: HisKA_3; pfam07730 889933005621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933005622 ATP binding site [chemical binding]; other site 889933005623 Mg2+ binding site [ion binding]; other site 889933005624 G-X-G motif; other site 889933005625 Predicted membrane protein [Function unknown]; Region: COG4758 889933005626 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 889933005627 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 889933005628 active site 889933005629 Predicted membrane protein [Function unknown]; Region: COG4129 889933005630 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 889933005631 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 889933005632 catalytic triad [active] 889933005633 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 889933005634 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889933005635 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 889933005636 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 889933005637 Ferritin-like domain; Region: Ferritin; pfam00210 889933005638 ferroxidase diiron center [ion binding]; other site 889933005639 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 889933005640 active site 889933005641 catalytic site [active] 889933005642 substrate binding site [chemical binding]; other site 889933005643 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 889933005644 active site 889933005645 DNA polymerase IV; Validated; Region: PRK02406 889933005646 DNA binding site [nucleotide binding] 889933005647 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 889933005648 TRAM domain; Region: TRAM; cl01282 889933005649 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 889933005650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933005651 S-adenosylmethionine binding site [chemical binding]; other site 889933005652 putative lipid kinase; Reviewed; Region: PRK13337 889933005653 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 889933005654 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 889933005655 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 889933005656 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 889933005657 GatB domain; Region: GatB_Yqey; pfam02637 889933005658 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 889933005659 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 889933005660 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 889933005661 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 889933005662 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 889933005663 Na binding site [ion binding]; other site 889933005664 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 889933005665 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 889933005666 putative dimer interface [polypeptide binding]; other site 889933005667 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 889933005668 putative dimer interface [polypeptide binding]; other site 889933005669 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 889933005670 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 889933005671 nucleotide binding pocket [chemical binding]; other site 889933005672 K-X-D-G motif; other site 889933005673 catalytic site [active] 889933005674 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 889933005675 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 889933005676 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 889933005677 Dimer interface [polypeptide binding]; other site 889933005678 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 889933005679 Part of AAA domain; Region: AAA_19; pfam13245 889933005680 Family description; Region: UvrD_C_2; pfam13538 889933005681 PcrB family; Region: PcrB; pfam01884 889933005682 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 889933005683 substrate binding site [chemical binding]; other site 889933005684 putative active site [active] 889933005685 dimer interface [polypeptide binding]; other site 889933005686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 889933005687 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 889933005688 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 889933005689 tetramer interface [polypeptide binding]; other site 889933005690 active site 889933005691 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 889933005692 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 889933005693 NETI protein; Region: NETI; pfam14044 889933005694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 889933005695 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 889933005696 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 889933005697 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 889933005698 homodimer interface [polypeptide binding]; other site 889933005699 NAD binding pocket [chemical binding]; other site 889933005700 ATP binding pocket [chemical binding]; other site 889933005701 Mg binding site [ion binding]; other site 889933005702 active-site loop [active] 889933005703 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 889933005704 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 889933005705 active site 889933005706 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 889933005707 active site 889933005708 dimer interface [polypeptide binding]; other site 889933005709 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 889933005710 Prephenate dehydratase; Region: PDT; pfam00800 889933005711 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 889933005712 putative L-Phe binding site [chemical binding]; other site 889933005713 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 889933005714 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 889933005715 transmembrane helices; other site 889933005716 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 889933005717 Isochorismatase family; Region: Isochorismatase; pfam00857 889933005718 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 889933005719 catalytic triad [active] 889933005720 conserved cis-peptide bond; other site 889933005721 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 889933005722 DHH family; Region: DHH; pfam01368 889933005723 DHHA2 domain; Region: DHHA2; pfam02833 889933005724 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 889933005725 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 889933005726 NAD(P) binding site [chemical binding]; other site 889933005727 catalytic residues [active] 889933005728 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 889933005729 YolD-like protein; Region: YolD; pfam08863 889933005730 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 889933005731 active site 889933005732 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 889933005733 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 889933005734 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 889933005735 Bacterial PH domain; Region: DUF304; cl01348 889933005736 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 889933005737 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889933005738 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 889933005739 Walker A/P-loop; other site 889933005740 ATP binding site [chemical binding]; other site 889933005741 Q-loop/lid; other site 889933005742 ABC transporter signature motif; other site 889933005743 Walker B; other site 889933005744 D-loop; other site 889933005745 H-loop/switch region; other site 889933005746 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 889933005747 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889933005748 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 889933005749 Walker A/P-loop; other site 889933005750 ATP binding site [chemical binding]; other site 889933005751 Q-loop/lid; other site 889933005752 ABC transporter signature motif; other site 889933005753 Walker B; other site 889933005754 D-loop; other site 889933005755 H-loop/switch region; other site 889933005756 Predicted transcriptional regulators [Transcription]; Region: COG1725 889933005757 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889933005758 DNA-binding site [nucleotide binding]; DNA binding site 889933005759 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 889933005760 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889933005761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933005762 homodimer interface [polypeptide binding]; other site 889933005763 catalytic residue [active] 889933005764 MAP domain; Region: MAP; pfam03642 889933005765 MAP domain; Region: MAP; pfam03642 889933005766 MAP domain; Region: MAP; pfam03642 889933005767 MAP domain; Region: MAP; pfam03642 889933005768 MAP domain; Region: MAP; pfam03642 889933005769 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 889933005770 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 889933005771 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 889933005772 Bacterial SH3 domain homologues; Region: SH3b; smart00287 889933005773 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 889933005774 CHAP domain; Region: CHAP; pfam05257 889933005775 Small integral membrane protein [Function unknown]; Region: COG5546 889933005776 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933005777 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933005778 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 889933005779 Ligand-gated ion channel; Region: Lig_chan; pfam00060 889933005780 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 889933005781 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 889933005782 Phage tail protein; Region: Sipho_tail; cl17486 889933005783 Phage tail protein; Region: Sipho_tail; cl17486 889933005784 Phage-related minor tail protein [Function unknown]; Region: COG5280 889933005785 Phage-related protein [Function unknown]; Region: COG5412 889933005786 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 889933005787 Peptidase family M23; Region: Peptidase_M23; pfam01551 889933005788 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 889933005789 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 889933005790 N-acetyl-D-glucosamine binding site [chemical binding]; other site 889933005791 catalytic residue [active] 889933005792 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 889933005793 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 889933005794 Translocation protein Sec62; Region: Sec62; cl02170 889933005795 Phage capsid family; Region: Phage_capsid; pfam05065 889933005796 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 889933005797 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 889933005798 oligomer interface [polypeptide binding]; other site 889933005799 active site residues [active] 889933005800 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 889933005801 Phage-related protein [Function unknown]; Region: COG4695; cl01923 889933005802 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 889933005803 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 889933005804 HNH endonuclease; Region: HNH; pfam01844 889933005805 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 889933005806 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 889933005807 Transcriptional activator RinB; Region: RinB; pfam06116 889933005808 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 889933005809 dUTPase; Region: dUTPase_2; pfam08761 889933005810 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 889933005811 active site 889933005812 homodimer interface [polypeptide binding]; other site 889933005813 metal binding site [ion binding]; metal-binding site 889933005814 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 889933005815 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 889933005816 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 889933005817 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 889933005818 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 889933005819 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 889933005820 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 889933005821 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 889933005822 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 889933005823 dimer interface [polypeptide binding]; other site 889933005824 ssDNA binding site [nucleotide binding]; other site 889933005825 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889933005826 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 889933005827 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 889933005828 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 889933005829 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 889933005830 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 889933005831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 889933005832 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 889933005833 Phage anti-repressor protein [Transcription]; Region: COG3561 889933005834 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 889933005835 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 889933005836 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 889933005837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889933005838 non-specific DNA binding site [nucleotide binding]; other site 889933005839 salt bridge; other site 889933005840 sequence-specific DNA binding site [nucleotide binding]; other site 889933005841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889933005842 non-specific DNA binding site [nucleotide binding]; other site 889933005843 salt bridge; other site 889933005844 sequence-specific DNA binding site [nucleotide binding]; other site 889933005845 Predicted transcriptional regulator [Transcription]; Region: COG2932 889933005846 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 889933005847 Catalytic site [active] 889933005848 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 889933005849 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 889933005850 active site 889933005851 catalytic site [active] 889933005852 substrate binding site [chemical binding]; other site 889933005853 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 889933005854 active site 889933005855 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 889933005856 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 889933005857 Int/Topo IB signature motif; other site 889933005858 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 889933005859 putative catalytic site [active] 889933005860 phosphate binding site [ion binding]; other site 889933005861 metal binding site A [ion binding]; metal-binding site 889933005862 metal binding site C [ion binding]; metal-binding site 889933005863 metal binding site B [ion binding]; metal-binding site 889933005864 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 889933005865 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 889933005866 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 889933005867 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 889933005868 metal binding site [ion binding]; metal-binding site 889933005869 dimer interface [polypeptide binding]; other site 889933005870 Cation transport protein; Region: TrkH; cl17365 889933005871 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 889933005872 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 889933005873 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 889933005874 ring oligomerisation interface [polypeptide binding]; other site 889933005875 ATP/Mg binding site [chemical binding]; other site 889933005876 stacking interactions; other site 889933005877 hinge regions; other site 889933005878 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 889933005879 oligomerisation interface [polypeptide binding]; other site 889933005880 mobile loop; other site 889933005881 roof hairpin; other site 889933005882 CAAX protease self-immunity; Region: Abi; pfam02517 889933005883 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 889933005884 dimer interface [polypeptide binding]; other site 889933005885 FMN binding site [chemical binding]; other site 889933005886 Predicted amidohydrolase [General function prediction only]; Region: COG0388 889933005887 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 889933005888 putative active site [active] 889933005889 catalytic triad [active] 889933005890 putative dimer interface [polypeptide binding]; other site 889933005891 delta-hemolysin; Provisional; Region: PRK14752 889933005892 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512 889933005893 Staphylococcal AgrD protein; Region: AgrD; pfam05931 889933005894 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 889933005895 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 889933005896 Mg2+ binding site [ion binding]; other site 889933005897 G-X-G motif; other site 889933005898 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 889933005899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933005900 active site 889933005901 phosphorylation site [posttranslational modification] 889933005902 intermolecular recognition site; other site 889933005903 dimerization interface [polypeptide binding]; other site 889933005904 LytTr DNA-binding domain; Region: LytTR; pfam04397 889933005905 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 889933005906 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 889933005907 putative substrate binding site [chemical binding]; other site 889933005908 putative ATP binding site [chemical binding]; other site 889933005909 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 889933005910 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 889933005911 substrate binding [chemical binding]; other site 889933005912 active site 889933005913 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 889933005914 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889933005915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889933005916 DNA binding site [nucleotide binding] 889933005917 domain linker motif; other site 889933005918 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 889933005919 dimerization interface [polypeptide binding]; other site 889933005920 ligand binding site [chemical binding]; other site 889933005921 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 889933005922 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 889933005923 CPxP motif; other site 889933005924 Predicted transporter component [General function prediction only]; Region: COG2391 889933005925 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 889933005926 Sulphur transport; Region: Sulf_transp; pfam04143 889933005927 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 889933005928 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 889933005929 CoA binding domain; Region: CoA_binding; pfam02629 889933005930 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 889933005931 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 889933005932 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 889933005933 ABC transporter; Region: ABC_tran_2; pfam12848 889933005934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 889933005935 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 889933005936 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 889933005937 Walker A/P-loop; other site 889933005938 ATP binding site [chemical binding]; other site 889933005939 Q-loop/lid; other site 889933005940 ABC transporter signature motif; other site 889933005941 Walker B; other site 889933005942 D-loop; other site 889933005943 H-loop/switch region; other site 889933005944 UGMP family protein; Validated; Region: PRK09604 889933005945 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 889933005946 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 889933005947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933005948 Coenzyme A binding pocket [chemical binding]; other site 889933005949 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 889933005950 Glycoprotease family; Region: Peptidase_M22; pfam00814 889933005951 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 889933005952 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 889933005953 6-phosphogluconate dehydratase; Region: edd; TIGR01196 889933005954 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 889933005955 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 889933005956 PYR/PP interface [polypeptide binding]; other site 889933005957 dimer interface [polypeptide binding]; other site 889933005958 TPP binding site [chemical binding]; other site 889933005959 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 889933005960 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 889933005961 TPP-binding site [chemical binding]; other site 889933005962 dimer interface [polypeptide binding]; other site 889933005963 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 889933005964 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 889933005965 ketol-acid reductoisomerase; Provisional; Region: PRK05479 889933005966 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 889933005967 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 889933005968 2-isopropylmalate synthase; Validated; Region: PRK00915 889933005969 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 889933005970 active site 889933005971 catalytic residues [active] 889933005972 metal binding site [ion binding]; metal-binding site 889933005973 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 889933005974 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 889933005975 tartrate dehydrogenase; Region: TTC; TIGR02089 889933005976 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 889933005977 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 889933005978 substrate binding site [chemical binding]; other site 889933005979 ligand binding site [chemical binding]; other site 889933005980 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 889933005981 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 889933005982 substrate binding site [chemical binding]; other site 889933005983 threonine dehydratase; Validated; Region: PRK08639 889933005984 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 889933005985 tetramer interface [polypeptide binding]; other site 889933005986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933005987 catalytic residue [active] 889933005988 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 889933005989 putative Ile/Val binding site [chemical binding]; other site 889933005990 hypothetical protein; Provisional; Region: PRK04351 889933005991 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 889933005992 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 889933005993 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 889933005994 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 889933005995 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 889933005996 RNA binding site [nucleotide binding]; other site 889933005997 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 889933005998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889933005999 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 889933006000 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 889933006001 DNA binding residues [nucleotide binding] 889933006002 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 889933006003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933006004 ATP binding site [chemical binding]; other site 889933006005 Mg2+ binding site [ion binding]; other site 889933006006 G-X-G motif; other site 889933006007 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 889933006008 anti sigma factor interaction site; other site 889933006009 regulatory phosphorylation site [posttranslational modification]; other site 889933006010 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 889933006011 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 889933006012 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 889933006013 PemK-like protein; Region: PemK; pfam02452 889933006014 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 889933006015 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 889933006016 active site 889933006017 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889933006018 dimer interface [polypeptide binding]; other site 889933006019 substrate binding site [chemical binding]; other site 889933006020 catalytic residues [active] 889933006021 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 889933006022 Uncharacterized conserved protein [Function unknown]; Region: COG3402 889933006023 Predicted membrane protein [Function unknown]; Region: COG3428 889933006024 Bacterial PH domain; Region: DUF304; pfam03703 889933006025 Bacterial PH domain; Region: DUF304; pfam03703 889933006026 Bacterial PH domain; Region: DUF304; cl01348 889933006027 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 889933006028 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 889933006029 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889933006030 Soluble P-type ATPase [General function prediction only]; Region: COG4087 889933006031 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 889933006032 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 889933006033 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 889933006034 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 889933006035 Ligand Binding Site [chemical binding]; other site 889933006036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889933006037 dimer interface [polypeptide binding]; other site 889933006038 phosphorylation site [posttranslational modification] 889933006039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933006040 ATP binding site [chemical binding]; other site 889933006041 Mg2+ binding site [ion binding]; other site 889933006042 G-X-G motif; other site 889933006043 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889933006044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933006045 active site 889933006046 phosphorylation site [posttranslational modification] 889933006047 intermolecular recognition site; other site 889933006048 dimerization interface [polypeptide binding]; other site 889933006049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889933006050 DNA binding site [nucleotide binding] 889933006051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889933006052 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889933006053 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 889933006054 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 889933006055 ATP binding site [chemical binding]; other site 889933006056 Mg++ binding site [ion binding]; other site 889933006057 motif III; other site 889933006058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889933006059 nucleotide binding region [chemical binding]; other site 889933006060 ATP-binding site [chemical binding]; other site 889933006061 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 889933006062 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 889933006063 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889933006064 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889933006065 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 889933006066 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 889933006067 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 889933006068 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 889933006069 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 889933006070 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 889933006071 putative homodimer interface [polypeptide binding]; other site 889933006072 putative homotetramer interface [polypeptide binding]; other site 889933006073 allosteric switch controlling residues; other site 889933006074 putative metal binding site [ion binding]; other site 889933006075 putative homodimer-homodimer interface [polypeptide binding]; other site 889933006076 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 889933006077 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 889933006078 putative active site [active] 889933006079 catalytic site [active] 889933006080 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 889933006081 putative active site [active] 889933006082 catalytic site [active] 889933006083 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 889933006084 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889933006085 Zn2+ binding site [ion binding]; other site 889933006086 Mg2+ binding site [ion binding]; other site 889933006087 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 889933006088 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 889933006089 thiamine phosphate binding site [chemical binding]; other site 889933006090 active site 889933006091 pyrophosphate binding site [ion binding]; other site 889933006092 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 889933006093 substrate binding site [chemical binding]; other site 889933006094 multimerization interface [polypeptide binding]; other site 889933006095 ATP binding site [chemical binding]; other site 889933006096 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 889933006097 dimer interface [polypeptide binding]; other site 889933006098 substrate binding site [chemical binding]; other site 889933006099 ATP binding site [chemical binding]; other site 889933006100 thiaminase II; Region: salvage_TenA; TIGR04306 889933006101 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 889933006102 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 889933006103 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 889933006104 dimer interface [polypeptide binding]; other site 889933006105 ssDNA binding site [nucleotide binding]; other site 889933006106 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889933006107 YwpF-like protein; Region: YwpF; pfam14183 889933006108 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 889933006109 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 889933006110 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 889933006111 hinge; other site 889933006112 active site 889933006113 Predicted membrane protein [Function unknown]; Region: COG4836 889933006114 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 889933006115 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 889933006116 gamma subunit interface [polypeptide binding]; other site 889933006117 epsilon subunit interface [polypeptide binding]; other site 889933006118 LBP interface [polypeptide binding]; other site 889933006119 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 889933006120 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 889933006121 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 889933006122 alpha subunit interaction interface [polypeptide binding]; other site 889933006123 Walker A motif; other site 889933006124 ATP binding site [chemical binding]; other site 889933006125 Walker B motif; other site 889933006126 inhibitor binding site; inhibition site 889933006127 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 889933006128 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 889933006129 core domain interface [polypeptide binding]; other site 889933006130 delta subunit interface [polypeptide binding]; other site 889933006131 epsilon subunit interface [polypeptide binding]; other site 889933006132 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 889933006133 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 889933006134 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 889933006135 beta subunit interaction interface [polypeptide binding]; other site 889933006136 Walker A motif; other site 889933006137 ATP binding site [chemical binding]; other site 889933006138 Walker B motif; other site 889933006139 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 889933006140 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 889933006141 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 889933006142 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 889933006143 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 889933006144 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 889933006145 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 889933006146 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 889933006147 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 889933006148 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 889933006149 active site 889933006150 homodimer interface [polypeptide binding]; other site 889933006151 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889933006152 active site 889933006153 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 889933006154 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 889933006155 dimer interface [polypeptide binding]; other site 889933006156 active site 889933006157 glycine-pyridoxal phosphate binding site [chemical binding]; other site 889933006158 folate binding site [chemical binding]; other site 889933006159 hypothetical protein; Provisional; Region: PRK13690 889933006160 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 889933006161 Low molecular weight phosphatase family; Region: LMWPc; cd00115 889933006162 active site 889933006163 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 889933006164 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 889933006165 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 889933006166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933006167 S-adenosylmethionine binding site [chemical binding]; other site 889933006168 peptide chain release factor 1; Validated; Region: prfA; PRK00591 889933006169 This domain is found in peptide chain release factors; Region: PCRF; smart00937 889933006170 RF-1 domain; Region: RF-1; pfam00472 889933006171 thymidine kinase; Provisional; Region: PRK04296 889933006172 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 889933006173 transcription termination factor Rho; Provisional; Region: rho; PRK09376 889933006174 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 889933006175 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 889933006176 RNA binding site [nucleotide binding]; other site 889933006177 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 889933006178 multimer interface [polypeptide binding]; other site 889933006179 Walker A motif; other site 889933006180 ATP binding site [chemical binding]; other site 889933006181 Walker B motif; other site 889933006182 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 889933006183 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 889933006184 NAD binding site [chemical binding]; other site 889933006185 catalytic residues [active] 889933006186 Predicted transcriptional regulators [Transcription]; Region: COG1733 889933006187 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 889933006188 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 889933006189 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 889933006190 hinge; other site 889933006191 active site 889933006192 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 889933006193 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 889933006194 intersubunit interface [polypeptide binding]; other site 889933006195 active site 889933006196 zinc binding site [ion binding]; other site 889933006197 Na+ binding site [ion binding]; other site 889933006198 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 889933006199 CTP synthetase; Validated; Region: pyrG; PRK05380 889933006200 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 889933006201 Catalytic site [active] 889933006202 active site 889933006203 UTP binding site [chemical binding]; other site 889933006204 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 889933006205 active site 889933006206 putative oxyanion hole; other site 889933006207 catalytic triad [active] 889933006208 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 889933006209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933006210 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 889933006211 Coenzyme A binding pocket [chemical binding]; other site 889933006212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 889933006213 Coenzyme A binding pocket [chemical binding]; other site 889933006214 pantothenate kinase; Provisional; Region: PRK13317 889933006215 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 889933006216 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 889933006217 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 889933006218 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 889933006219 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 889933006220 metal binding site [ion binding]; metal-binding site 889933006221 S-ribosylhomocysteinase; Provisional; Region: PRK02260 889933006222 Predicted membrane protein [Function unknown]; Region: COG4270 889933006223 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 889933006224 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 889933006225 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 889933006226 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 889933006227 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 889933006228 intersubunit interface [polypeptide binding]; other site 889933006229 active site 889933006230 catalytic residue [active] 889933006231 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 889933006232 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 889933006233 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 889933006234 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 889933006235 dimerization interface [polypeptide binding]; other site 889933006236 DPS ferroxidase diiron center [ion binding]; other site 889933006237 ion pore; other site 889933006238 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 889933006239 EVE domain; Region: EVE; cl00728 889933006240 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 889933006241 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 889933006242 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 889933006243 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889933006244 NAD(P) binding site [chemical binding]; other site 889933006245 putative active site [active] 889933006246 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889933006247 dimerization interface [polypeptide binding]; other site 889933006248 putative DNA binding site [nucleotide binding]; other site 889933006249 putative Zn2+ binding site [ion binding]; other site 889933006250 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 889933006251 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 889933006252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 889933006253 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 889933006254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933006255 active site 889933006256 motif I; other site 889933006257 motif II; other site 889933006258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933006259 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889933006260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933006261 Walker A/P-loop; other site 889933006262 ATP binding site [chemical binding]; other site 889933006263 Q-loop/lid; other site 889933006264 ABC transporter signature motif; other site 889933006265 Walker B; other site 889933006266 D-loop; other site 889933006267 H-loop/switch region; other site 889933006268 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 889933006269 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 889933006270 glutaminase active site [active] 889933006271 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 889933006272 dimer interface [polypeptide binding]; other site 889933006273 active site 889933006274 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 889933006275 dimer interface [polypeptide binding]; other site 889933006276 active site 889933006277 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 889933006278 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 889933006279 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 889933006280 active site 889933006281 P-loop; other site 889933006282 phosphorylation site [posttranslational modification] 889933006283 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 889933006284 HTH domain; Region: HTH_11; pfam08279 889933006285 Mga helix-turn-helix domain; Region: Mga; pfam05043 889933006286 PRD domain; Region: PRD; pfam00874 889933006287 PRD domain; Region: PRD; pfam00874 889933006288 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 889933006289 active site 889933006290 P-loop; other site 889933006291 phosphorylation site [posttranslational modification] 889933006292 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 889933006293 active site 889933006294 phosphorylation site [posttranslational modification] 889933006295 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889933006296 active site 889933006297 phosphorylation site [posttranslational modification] 889933006298 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 889933006299 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 889933006300 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 889933006301 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933006302 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 889933006303 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933006304 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933006305 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933006306 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933006307 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 889933006308 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 889933006309 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 889933006310 active site 889933006311 substrate binding site [chemical binding]; other site 889933006312 metal binding site [ion binding]; metal-binding site 889933006313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 889933006314 YbbR-like protein; Region: YbbR; pfam07949 889933006315 TIGR00159 family protein; Region: TIGR00159 889933006316 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 889933006317 Arginase family; Region: Arginase; cd09989 889933006318 active site 889933006319 Mn binding site [ion binding]; other site 889933006320 oligomer interface [polypeptide binding]; other site 889933006321 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 889933006322 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 889933006323 Walker A motif; other site 889933006324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933006325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889933006326 putative substrate translocation pore; other site 889933006327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933006328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889933006329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933006330 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 889933006331 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 889933006332 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 889933006333 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 889933006334 substrate binding site; other site 889933006335 dimerization interface; other site 889933006336 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 889933006337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 889933006338 Nucleoside recognition; Region: Gate; pfam07670 889933006339 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 889933006340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933006341 ABC-ATPase subunit interface; other site 889933006342 dimer interface [polypeptide binding]; other site 889933006343 putative PBP binding regions; other site 889933006344 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 889933006345 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889933006346 ABC-ATPase subunit interface; other site 889933006347 dimer interface [polypeptide binding]; other site 889933006348 putative PBP binding regions; other site 889933006349 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 889933006350 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 889933006351 siderophore binding site; other site 889933006352 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 889933006353 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 889933006354 dimer interface [polypeptide binding]; other site 889933006355 active site 889933006356 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889933006357 substrate binding site [chemical binding]; other site 889933006358 catalytic residue [active] 889933006359 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 889933006360 IucA / IucC family; Region: IucA_IucC; pfam04183 889933006361 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 889933006362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933006363 putative substrate translocation pore; other site 889933006364 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 889933006365 IucA / IucC family; Region: IucA_IucC; pfam04183 889933006366 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 889933006367 Asp23 family; Region: Asp23; pfam03780 889933006368 Small integral membrane protein [Function unknown]; Region: COG5547 889933006369 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 889933006370 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 889933006371 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 889933006372 putative NAD(P) binding site [chemical binding]; other site 889933006373 dimer interface [polypeptide binding]; other site 889933006374 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 889933006375 Prostaglandin dehydrogenases; Region: PGDH; cd05288 889933006376 NAD(P) binding site [chemical binding]; other site 889933006377 substrate binding site [chemical binding]; other site 889933006378 dimer interface [polypeptide binding]; other site 889933006379 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 889933006380 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 889933006381 beta-galactosidase; Region: BGL; TIGR03356 889933006382 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 889933006383 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 889933006384 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 889933006385 active site 889933006386 P-loop; other site 889933006387 phosphorylation site [posttranslational modification] 889933006388 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 889933006389 methionine cluster; other site 889933006390 active site 889933006391 phosphorylation site [posttranslational modification] 889933006392 metal binding site [ion binding]; metal-binding site 889933006393 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 889933006394 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 889933006395 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 889933006396 putative substrate binding site [chemical binding]; other site 889933006397 putative ATP binding site [chemical binding]; other site 889933006398 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 889933006399 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 889933006400 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 889933006401 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 889933006402 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 889933006403 NAD-dependent deacetylase; Provisional; Region: PRK00481 889933006404 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 889933006405 NAD+ binding site [chemical binding]; other site 889933006406 substrate binding site [chemical binding]; other site 889933006407 putative Zn binding site [ion binding]; other site 889933006408 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889933006409 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889933006410 active site 889933006411 catalytic tetrad [active] 889933006412 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 889933006413 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 889933006414 DNA binding residues [nucleotide binding] 889933006415 putative dimer interface [polypeptide binding]; other site 889933006416 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 889933006417 substrate binding site [chemical binding]; other site 889933006418 catalytic residues [active] 889933006419 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 889933006420 Peptidase family M23; Region: Peptidase_M23; pfam01551 889933006421 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 889933006422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 889933006423 active site 889933006424 motif I; other site 889933006425 motif II; other site 889933006426 MAP domain; Region: MAP; pfam03642 889933006427 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 889933006428 acetolactate synthase; Reviewed; Region: PRK08617 889933006429 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 889933006430 PYR/PP interface [polypeptide binding]; other site 889933006431 dimer interface [polypeptide binding]; other site 889933006432 TPP binding site [chemical binding]; other site 889933006433 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 889933006434 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 889933006435 TPP-binding site [chemical binding]; other site 889933006436 potential frameshift: common BLAST hit: gi|150394717|ref|YP_001317392.1| RNA-directed DNA polymerase 889933006437 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 889933006438 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 889933006439 putative active site [active] 889933006440 putative NTP binding site [chemical binding]; other site 889933006441 putative nucleic acid binding site [nucleotide binding]; other site 889933006442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 889933006443 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 889933006444 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 889933006445 23S rRNA interface [nucleotide binding]; other site 889933006446 L3 interface [polypeptide binding]; other site 889933006447 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 889933006448 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 889933006449 dimerization interface 3.5A [polypeptide binding]; other site 889933006450 active site 889933006451 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 889933006452 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 889933006453 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 889933006454 Walker A/P-loop; other site 889933006455 ATP binding site [chemical binding]; other site 889933006456 Q-loop/lid; other site 889933006457 ABC transporter signature motif; other site 889933006458 Walker B; other site 889933006459 D-loop; other site 889933006460 H-loop/switch region; other site 889933006461 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 889933006462 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 889933006463 Walker A/P-loop; other site 889933006464 ATP binding site [chemical binding]; other site 889933006465 Q-loop/lid; other site 889933006466 ABC transporter signature motif; other site 889933006467 Walker B; other site 889933006468 D-loop; other site 889933006469 H-loop/switch region; other site 889933006470 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 889933006471 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 889933006472 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 889933006473 alphaNTD homodimer interface [polypeptide binding]; other site 889933006474 alphaNTD - beta interaction site [polypeptide binding]; other site 889933006475 alphaNTD - beta' interaction site [polypeptide binding]; other site 889933006476 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 889933006477 30S ribosomal protein S11; Validated; Region: PRK05309 889933006478 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 889933006479 30S ribosomal protein S13; Region: bact_S13; TIGR03631 889933006480 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 889933006481 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 889933006482 rRNA binding site [nucleotide binding]; other site 889933006483 predicted 30S ribosome binding site; other site 889933006484 adenylate kinase; Reviewed; Region: adk; PRK00279 889933006485 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 889933006486 AMP-binding site [chemical binding]; other site 889933006487 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 889933006488 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 889933006489 SecY translocase; Region: SecY; pfam00344 889933006490 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 889933006491 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 889933006492 23S rRNA binding site [nucleotide binding]; other site 889933006493 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 889933006494 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 889933006495 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 889933006496 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 889933006497 5S rRNA interface [nucleotide binding]; other site 889933006498 L27 interface [polypeptide binding]; other site 889933006499 23S rRNA interface [nucleotide binding]; other site 889933006500 L5 interface [polypeptide binding]; other site 889933006501 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 889933006502 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 889933006503 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 889933006504 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 889933006505 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 889933006506 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 889933006507 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 889933006508 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 889933006509 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 889933006510 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 889933006511 RNA binding site [nucleotide binding]; other site 889933006512 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 889933006513 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 889933006514 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 889933006515 23S rRNA interface [nucleotide binding]; other site 889933006516 putative translocon interaction site; other site 889933006517 signal recognition particle (SRP54) interaction site; other site 889933006518 L23 interface [polypeptide binding]; other site 889933006519 trigger factor interaction site; other site 889933006520 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 889933006521 23S rRNA interface [nucleotide binding]; other site 889933006522 5S rRNA interface [nucleotide binding]; other site 889933006523 putative antibiotic binding site [chemical binding]; other site 889933006524 L25 interface [polypeptide binding]; other site 889933006525 L27 interface [polypeptide binding]; other site 889933006526 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 889933006527 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 889933006528 G-X-X-G motif; other site 889933006529 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 889933006530 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 889933006531 putative translocon binding site; other site 889933006532 protein-rRNA interface [nucleotide binding]; other site 889933006533 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 889933006534 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 889933006535 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 889933006536 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 889933006537 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 889933006538 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 889933006539 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 889933006540 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 889933006541 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 889933006542 DNA topoisomerase III; Provisional; Region: PRK07726 889933006543 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 889933006544 active site 889933006545 putative interdomain interaction site [polypeptide binding]; other site 889933006546 putative metal-binding site [ion binding]; other site 889933006547 putative nucleotide binding site [chemical binding]; other site 889933006548 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 889933006549 domain I; other site 889933006550 DNA binding groove [nucleotide binding] 889933006551 phosphate binding site [ion binding]; other site 889933006552 domain II; other site 889933006553 domain III; other site 889933006554 nucleotide binding site [chemical binding]; other site 889933006555 catalytic site [active] 889933006556 domain IV; other site 889933006557 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 889933006558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933006559 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 889933006560 Coenzyme A binding pocket [chemical binding]; other site 889933006561 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 889933006562 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 889933006563 Predicted permeases [General function prediction only]; Region: COG0679 889933006564 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 889933006565 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 889933006566 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 889933006567 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 889933006568 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 889933006569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933006570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889933006571 putative substrate translocation pore; other site 889933006572 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933006573 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889933006574 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 889933006575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889933006576 FeS/SAM binding site; other site 889933006577 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 889933006578 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 889933006579 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 889933006580 GTP binding site; other site 889933006581 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 889933006582 MoaE interaction surface [polypeptide binding]; other site 889933006583 MoeB interaction surface [polypeptide binding]; other site 889933006584 thiocarboxylated glycine; other site 889933006585 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 889933006586 MoaE homodimer interface [polypeptide binding]; other site 889933006587 MoaD interaction [polypeptide binding]; other site 889933006588 active site residues [active] 889933006589 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 889933006590 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 889933006591 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 889933006592 dimer interface [polypeptide binding]; other site 889933006593 putative functional site; other site 889933006594 putative MPT binding site; other site 889933006595 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 889933006596 trimer interface [polypeptide binding]; other site 889933006597 dimer interface [polypeptide binding]; other site 889933006598 putative active site [active] 889933006599 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 889933006600 MPT binding site; other site 889933006601 trimer interface [polypeptide binding]; other site 889933006602 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 889933006603 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 889933006604 ATP binding site [chemical binding]; other site 889933006605 substrate interface [chemical binding]; other site 889933006606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933006607 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 889933006608 Walker A/P-loop; other site 889933006609 ATP binding site [chemical binding]; other site 889933006610 Q-loop/lid; other site 889933006611 ABC transporter signature motif; other site 889933006612 Walker B; other site 889933006613 D-loop; other site 889933006614 H-loop/switch region; other site 889933006615 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 889933006616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933006617 dimer interface [polypeptide binding]; other site 889933006618 conserved gate region; other site 889933006619 putative PBP binding loops; other site 889933006620 ABC-ATPase subunit interface; other site 889933006621 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 889933006622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889933006623 substrate binding pocket [chemical binding]; other site 889933006624 membrane-bound complex binding site; other site 889933006625 hinge residues; other site 889933006626 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 889933006627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933006628 Coenzyme A binding pocket [chemical binding]; other site 889933006629 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 889933006630 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 889933006631 active site 889933006632 dimerization interface [polypeptide binding]; other site 889933006633 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 889933006634 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889933006635 intersubunit interface [polypeptide binding]; other site 889933006636 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 889933006637 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 889933006638 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 889933006639 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 889933006640 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 889933006641 alpha-gamma subunit interface [polypeptide binding]; other site 889933006642 beta-gamma subunit interface [polypeptide binding]; other site 889933006643 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 889933006644 gamma-beta subunit interface [polypeptide binding]; other site 889933006645 alpha-beta subunit interface [polypeptide binding]; other site 889933006646 urease subunit alpha; Reviewed; Region: ureC; PRK13207 889933006647 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 889933006648 subunit interactions [polypeptide binding]; other site 889933006649 active site 889933006650 flap region; other site 889933006651 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 889933006652 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 889933006653 dimer interface [polypeptide binding]; other site 889933006654 catalytic residues [active] 889933006655 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 889933006656 UreF; Region: UreF; pfam01730 889933006657 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 889933006658 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 889933006659 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933006660 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933006661 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933006662 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889933006663 Helix-turn-helix domain; Region: HTH_18; pfam12833 889933006664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889933006665 Surface antigen [General function prediction only]; Region: COG3942 889933006666 CHAP domain; Region: CHAP; pfam05257 889933006667 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 889933006668 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 889933006669 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 889933006670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 889933006671 Surface antigen [General function prediction only]; Region: COG3942 889933006672 CHAP domain; Region: CHAP; pfam05257 889933006673 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 889933006674 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 889933006675 putative ligand binding site [chemical binding]; other site 889933006676 putative NAD binding site [chemical binding]; other site 889933006677 catalytic site [active] 889933006678 hypothetical protein; Provisional; Region: PRK06753 889933006679 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 889933006680 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 889933006681 Lysozyme subfamily 2; Region: LYZ2; smart00047 889933006682 Uncharacterized conserved protein [Function unknown]; Region: COG2427 889933006683 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 889933006684 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 889933006685 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 889933006686 4Fe-4S binding domain; Region: Fer4; pfam00037 889933006687 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 889933006688 [4Fe-4S] binding site [ion binding]; other site 889933006689 molybdopterin cofactor binding site; other site 889933006690 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 889933006691 molybdopterin cofactor binding site; other site 889933006692 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 889933006693 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 889933006694 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 889933006695 active site 889933006696 Predicted transcriptional regulator [Transcription]; Region: COG2378 889933006697 HTH domain; Region: HTH_11; pfam08279 889933006698 CAAX protease self-immunity; Region: Abi; pfam02517 889933006699 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 889933006700 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 889933006701 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 889933006702 putative active site [active] 889933006703 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 889933006704 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 889933006705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933006706 active site 889933006707 motif I; other site 889933006708 motif II; other site 889933006709 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 889933006710 Sodium Bile acid symporter family; Region: SBF; pfam01758 889933006711 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 889933006712 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 889933006713 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889933006714 active site turn [active] 889933006715 phosphorylation site [posttranslational modification] 889933006716 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 889933006717 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 889933006718 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 889933006719 putative active site [active] 889933006720 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 889933006721 putative hydrophobic ligand binding site [chemical binding]; other site 889933006722 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 889933006723 oxidoreductase; Provisional; Region: PRK07985 889933006724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889933006725 NAD(P) binding site [chemical binding]; other site 889933006726 active site 889933006727 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 889933006728 amidohydrolase; Region: amidohydrolases; TIGR01891 889933006729 metal binding site [ion binding]; metal-binding site 889933006730 dimer interface [polypeptide binding]; other site 889933006731 imidazolonepropionase; Validated; Region: PRK09356 889933006732 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 889933006733 active site 889933006734 urocanate hydratase; Provisional; Region: PRK05414 889933006735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889933006736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 889933006737 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889933006738 dimerization interface [polypeptide binding]; other site 889933006739 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 889933006740 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 889933006741 putative active site [active] 889933006742 putative Mg binding site [ion binding]; other site 889933006743 formimidoylglutamase; Provisional; Region: PRK13775 889933006744 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 889933006745 putative active site [active] 889933006746 putative metal binding site [ion binding]; other site 889933006747 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 889933006748 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 889933006749 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889933006750 active site 889933006751 dimer interface [polypeptide binding]; other site 889933006752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 889933006753 MOSC domain; Region: MOSC; pfam03473 889933006754 3-alpha domain; Region: 3-alpha; pfam03475 889933006755 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 889933006756 active site 889933006757 catalytic residues [active] 889933006758 Uncharacterized conserved protein [Function unknown]; Region: COG1742 889933006759 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 889933006760 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 889933006761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933006762 Walker A/P-loop; other site 889933006763 ATP binding site [chemical binding]; other site 889933006764 Q-loop/lid; other site 889933006765 ABC transporter signature motif; other site 889933006766 Walker B; other site 889933006767 D-loop; other site 889933006768 H-loop/switch region; other site 889933006769 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 889933006770 Predicted membrane protein [Function unknown]; Region: COG3152 889933006771 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 889933006772 active site 889933006773 DNA binding site [nucleotide binding] 889933006774 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 889933006775 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 889933006776 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 889933006777 homotetramer interface [polypeptide binding]; other site 889933006778 FMN binding site [chemical binding]; other site 889933006779 homodimer contacts [polypeptide binding]; other site 889933006780 putative active site [active] 889933006781 putative substrate binding site [chemical binding]; other site 889933006782 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 889933006783 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 889933006784 oligomer interface [polypeptide binding]; other site 889933006785 metal binding site [ion binding]; metal-binding site 889933006786 metal binding site [ion binding]; metal-binding site 889933006787 putative Cl binding site [ion binding]; other site 889933006788 aspartate ring; other site 889933006789 basic sphincter; other site 889933006790 hydrophobic gate; other site 889933006791 periplasmic entrance; other site 889933006792 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 889933006793 active site 889933006794 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 889933006795 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 889933006796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933006797 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 889933006798 putative substrate translocation pore; other site 889933006799 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 889933006800 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 889933006801 HlyD family secretion protein; Region: HlyD_3; pfam13437 889933006802 lipoyl-biotinyl attachment site [posttranslational modification]; other site 889933006803 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 889933006804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933006805 putative substrate translocation pore; other site 889933006806 Predicted membrane protein [Function unknown]; Region: COG4640 889933006807 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 889933006808 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889933006809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889933006810 putative Zn2+ binding site [ion binding]; other site 889933006811 putative DNA binding site [nucleotide binding]; other site 889933006812 Uncharacterized conserved protein [Function unknown]; Region: COG1434 889933006813 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 889933006814 putative active site [active] 889933006815 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889933006816 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 889933006817 Walker A/P-loop; other site 889933006818 ATP binding site [chemical binding]; other site 889933006819 Q-loop/lid; other site 889933006820 ABC transporter signature motif; other site 889933006821 Walker B; other site 889933006822 D-loop; other site 889933006823 H-loop/switch region; other site 889933006824 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889933006825 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 889933006826 FtsX-like permease family; Region: FtsX; pfam02687 889933006827 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889933006828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933006829 active site 889933006830 phosphorylation site [posttranslational modification] 889933006831 intermolecular recognition site; other site 889933006832 dimerization interface [polypeptide binding]; other site 889933006833 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889933006834 DNA binding site [nucleotide binding] 889933006835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 889933006836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 889933006837 dimerization interface [polypeptide binding]; other site 889933006838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889933006839 dimer interface [polypeptide binding]; other site 889933006840 phosphorylation site [posttranslational modification] 889933006841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933006842 ATP binding site [chemical binding]; other site 889933006843 Mg2+ binding site [ion binding]; other site 889933006844 G-X-G motif; other site 889933006845 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 889933006846 LytTr DNA-binding domain; Region: LytTR; smart00850 889933006847 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 889933006848 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 889933006849 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 889933006850 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 889933006851 L-lactate permease; Region: Lactate_perm; cl00701 889933006852 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 889933006853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933006854 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 889933006855 Coenzyme A binding pocket [chemical binding]; other site 889933006856 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 889933006857 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 889933006858 NAD(P) binding site [chemical binding]; other site 889933006859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933006860 Coenzyme A binding pocket [chemical binding]; other site 889933006861 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 889933006862 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 889933006863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933006864 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 889933006865 Predicted membrane protein [Function unknown]; Region: COG1511 889933006866 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 889933006867 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 889933006868 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 889933006869 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 889933006870 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 889933006871 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 889933006872 Cl binding site [ion binding]; other site 889933006873 oligomer interface [polypeptide binding]; other site 889933006874 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 889933006875 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889933006876 active site turn [active] 889933006877 phosphorylation site [posttranslational modification] 889933006878 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 889933006879 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 889933006880 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 889933006881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889933006882 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 889933006883 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 889933006884 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 889933006885 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 889933006886 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 889933006887 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889933006888 MarR family; Region: MarR_2; pfam12802 889933006889 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 889933006890 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 889933006891 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 889933006892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933006893 putative substrate translocation pore; other site 889933006894 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 889933006895 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 889933006896 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 889933006897 DNA binding residues [nucleotide binding] 889933006898 dimer interface [polypeptide binding]; other site 889933006899 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 889933006900 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 889933006901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933006902 active site 889933006903 phosphorylation site [posttranslational modification] 889933006904 intermolecular recognition site; other site 889933006905 dimerization interface [polypeptide binding]; other site 889933006906 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889933006907 DNA binding residues [nucleotide binding] 889933006908 dimerization interface [polypeptide binding]; other site 889933006909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 889933006910 Histidine kinase; Region: HisKA_3; pfam07730 889933006911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933006912 ATP binding site [chemical binding]; other site 889933006913 Mg2+ binding site [ion binding]; other site 889933006914 G-X-G motif; other site 889933006915 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 889933006916 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 889933006917 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 889933006918 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 889933006919 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 889933006920 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 889933006921 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 889933006922 [4Fe-4S] binding site [ion binding]; other site 889933006923 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 889933006924 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 889933006925 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 889933006926 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 889933006927 molybdopterin cofactor binding site; other site 889933006928 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 889933006929 active site 889933006930 SAM binding site [chemical binding]; other site 889933006931 homodimer interface [polypeptide binding]; other site 889933006932 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 889933006933 [2Fe-2S] cluster binding site [ion binding]; other site 889933006934 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 889933006935 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 889933006936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889933006937 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 889933006938 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 889933006939 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 889933006940 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 889933006941 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 889933006942 putative active site [active] 889933006943 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 889933006944 active site 889933006945 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 889933006946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933006947 Coenzyme A binding pocket [chemical binding]; other site 889933006948 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 889933006949 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 889933006950 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 889933006951 putative hydrophobic ligand binding site [chemical binding]; other site 889933006952 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 889933006953 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889933006954 intersubunit interface [polypeptide binding]; other site 889933006955 YodA lipocalin-like domain; Region: YodA; pfam09223 889933006956 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 889933006957 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 889933006958 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 889933006959 Thioredoxin; Region: Thioredoxin_4; cl17273 889933006960 FemAB family; Region: FemAB; pfam02388 889933006961 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 889933006962 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 889933006963 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 889933006964 Walker A/P-loop; other site 889933006965 ATP binding site [chemical binding]; other site 889933006966 Q-loop/lid; other site 889933006967 ABC transporter signature motif; other site 889933006968 Walker B; other site 889933006969 D-loop; other site 889933006970 H-loop/switch region; other site 889933006971 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 889933006972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933006973 dimer interface [polypeptide binding]; other site 889933006974 conserved gate region; other site 889933006975 putative PBP binding loops; other site 889933006976 ABC-ATPase subunit interface; other site 889933006977 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 889933006978 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889933006979 substrate binding pocket [chemical binding]; other site 889933006980 membrane-bound complex binding site; other site 889933006981 hinge residues; other site 889933006982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933006983 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889933006984 putative substrate translocation pore; other site 889933006985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933006986 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889933006987 catalytic core [active] 889933006988 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889933006989 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 889933006990 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 889933006991 B domain; Region: B; pfam02216 889933006992 B domain; Region: B; pfam02216 889933006993 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 889933006994 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 889933006995 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 889933006996 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 889933006997 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 889933006998 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 889933006999 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 889933007000 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889933007001 catalytic residue [active] 889933007002 biotin synthase; Validated; Region: PRK06256 889933007003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889933007004 FeS/SAM binding site; other site 889933007005 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 889933007006 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889933007007 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 889933007008 inhibitor-cofactor binding pocket; inhibition site 889933007009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933007010 catalytic residue [active] 889933007011 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 889933007012 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 889933007013 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 889933007014 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889933007015 Walker A/P-loop; other site 889933007016 ATP binding site [chemical binding]; other site 889933007017 Q-loop/lid; other site 889933007018 ABC transporter signature motif; other site 889933007019 Walker B; other site 889933007020 D-loop; other site 889933007021 H-loop/switch region; other site 889933007022 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889933007023 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 889933007024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933007025 Walker A/P-loop; other site 889933007026 ATP binding site [chemical binding]; other site 889933007027 Q-loop/lid; other site 889933007028 ABC transporter signature motif; other site 889933007029 Walker B; other site 889933007030 D-loop; other site 889933007031 H-loop/switch region; other site 889933007032 Predicted membrane protein [Function unknown]; Region: COG2246 889933007033 GtrA-like protein; Region: GtrA; pfam04138 889933007034 glycerate kinase; Region: TIGR00045 889933007035 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 889933007036 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 889933007037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933007038 putative substrate translocation pore; other site 889933007039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 889933007040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 889933007041 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 889933007042 putative phosphoesterase; Region: acc_ester; TIGR03729 889933007043 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 889933007044 Spore germination protein; Region: Spore_permease; cl17796 889933007045 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 889933007046 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 889933007047 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 889933007048 Beta-lactamase; Region: Beta-lactamase; pfam00144 889933007049 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 889933007050 extended (e) SDRs; Region: SDR_e; cd08946 889933007051 NAD(P) binding site [chemical binding]; other site 889933007052 active site 889933007053 substrate binding site [chemical binding]; other site 889933007054 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 889933007055 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 889933007056 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 889933007057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933007058 putative substrate translocation pore; other site 889933007059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933007060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933007061 dimer interface [polypeptide binding]; other site 889933007062 conserved gate region; other site 889933007063 ABC-ATPase subunit interface; other site 889933007064 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 889933007065 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 889933007066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933007067 dimer interface [polypeptide binding]; other site 889933007068 conserved gate region; other site 889933007069 putative PBP binding loops; other site 889933007070 ABC-ATPase subunit interface; other site 889933007071 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 889933007072 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 889933007073 Walker A/P-loop; other site 889933007074 ATP binding site [chemical binding]; other site 889933007075 Q-loop/lid; other site 889933007076 ABC transporter signature motif; other site 889933007077 Walker B; other site 889933007078 D-loop; other site 889933007079 H-loop/switch region; other site 889933007080 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 889933007081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 889933007082 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 889933007083 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 889933007084 amino acid transporter; Region: 2A0306; TIGR00909 889933007085 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 889933007086 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 889933007087 substrate binding pocket [chemical binding]; other site 889933007088 catalytic triad [active] 889933007089 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 889933007090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933007091 putative substrate translocation pore; other site 889933007092 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 889933007093 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 889933007094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933007095 Walker A/P-loop; other site 889933007096 ATP binding site [chemical binding]; other site 889933007097 Q-loop/lid; other site 889933007098 ABC transporter signature motif; other site 889933007099 Walker B; other site 889933007100 D-loop; other site 889933007101 H-loop/switch region; other site 889933007102 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 889933007103 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 889933007104 oligomer interface [polypeptide binding]; other site 889933007105 active site 889933007106 metal binding site [ion binding]; metal-binding site 889933007107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 889933007108 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 889933007109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 889933007110 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 889933007111 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 889933007112 active site 889933007113 FMN binding site [chemical binding]; other site 889933007114 substrate binding site [chemical binding]; other site 889933007115 3Fe-4S cluster binding site [ion binding]; other site 889933007116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933007117 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889933007118 putative substrate translocation pore; other site 889933007119 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 889933007120 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 889933007121 Walker A/P-loop; other site 889933007122 ATP binding site [chemical binding]; other site 889933007123 Q-loop/lid; other site 889933007124 ABC transporter signature motif; other site 889933007125 Walker B; other site 889933007126 D-loop; other site 889933007127 H-loop/switch region; other site 889933007128 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 889933007129 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 889933007130 Walker A/P-loop; other site 889933007131 ATP binding site [chemical binding]; other site 889933007132 Q-loop/lid; other site 889933007133 ABC transporter signature motif; other site 889933007134 Walker B; other site 889933007135 D-loop; other site 889933007136 H-loop/switch region; other site 889933007137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889933007138 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 889933007139 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 889933007140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933007141 dimer interface [polypeptide binding]; other site 889933007142 conserved gate region; other site 889933007143 ABC-ATPase subunit interface; other site 889933007144 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889933007145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889933007146 dimer interface [polypeptide binding]; other site 889933007147 conserved gate region; other site 889933007148 putative PBP binding loops; other site 889933007149 ABC-ATPase subunit interface; other site 889933007150 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 889933007151 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 889933007152 substrate binding site [chemical binding]; other site 889933007153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 889933007154 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 889933007155 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 889933007156 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 889933007157 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 889933007158 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 889933007159 short chain dehydrogenase; Validated; Region: PRK08589 889933007160 classical (c) SDRs; Region: SDR_c; cd05233 889933007161 NAD(P) binding site [chemical binding]; other site 889933007162 active site 889933007163 AbgT putative transporter family; Region: ABG_transport; pfam03806 889933007164 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 889933007165 Uncharacterized conserved protein [Function unknown]; Region: COG2128 889933007166 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 889933007167 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 889933007168 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 889933007169 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 889933007170 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 889933007171 classical (c) SDRs; Region: SDR_c; cd05233 889933007172 NAD(P) binding site [chemical binding]; other site 889933007173 active site 889933007174 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 889933007175 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933007176 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933007177 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933007178 Protein of unknown function, DUF576; Region: DUF576; pfam04507 889933007179 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 889933007180 PLD-like domain; Region: PLDc_2; pfam13091 889933007181 putative homodimer interface [polypeptide binding]; other site 889933007182 putative active site [active] 889933007183 catalytic site [active] 889933007184 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 889933007185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889933007186 ATP binding site [chemical binding]; other site 889933007187 putative Mg++ binding site [ion binding]; other site 889933007188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889933007189 nucleotide binding region [chemical binding]; other site 889933007190 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 889933007191 ATP-binding site [chemical binding]; other site 889933007192 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 889933007193 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 889933007194 active site 889933007195 8-oxo-dGMP binding site [chemical binding]; other site 889933007196 nudix motif; other site 889933007197 metal binding site [ion binding]; metal-binding site 889933007198 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 889933007199 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 889933007200 active site 889933007201 substrate binding site [chemical binding]; other site 889933007202 metal binding site [ion binding]; metal-binding site 889933007203 H+ Antiporter protein; Region: 2A0121; TIGR00900 889933007204 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933007205 legume lectins; Region: lectin_L-type; cl14058 889933007206 homotetramer interaction site [polypeptide binding]; other site 889933007207 carbohydrate binding site [chemical binding]; other site 889933007208 metal binding site [ion binding]; metal-binding site 889933007209 G5 domain; Region: G5; pfam07501 889933007210 G5 domain; Region: G5; pfam07501 889933007211 G5 domain; Region: G5; pfam07501 889933007212 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 889933007213 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933007214 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889933007215 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933007216 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889933007217 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 889933007218 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 889933007219 tetramer interface; other site 889933007220 active site 889933007221 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 889933007222 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 889933007223 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 889933007224 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 889933007225 GntP family permease; Region: GntP_permease; pfam02447 889933007226 fructuronate transporter; Provisional; Region: PRK10034; cl15264 889933007227 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 889933007228 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 889933007229 N- and C-terminal domain interface [polypeptide binding]; other site 889933007230 active site 889933007231 catalytic site [active] 889933007232 metal binding site [ion binding]; metal-binding site 889933007233 carbohydrate binding site [chemical binding]; other site 889933007234 ATP binding site [chemical binding]; other site 889933007235 Transcriptional regulators [Transcription]; Region: GntR; COG1802 889933007236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889933007237 DNA-binding site [nucleotide binding]; DNA binding site 889933007238 FCD domain; Region: FCD; pfam07729 889933007239 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 889933007240 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 889933007241 DNA binding residues [nucleotide binding] 889933007242 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 889933007243 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 889933007244 synthetase active site [active] 889933007245 NTP binding site [chemical binding]; other site 889933007246 metal binding site [ion binding]; metal-binding site 889933007247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 889933007248 Predicted membrane protein [Function unknown]; Region: COG1289 889933007249 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 889933007250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889933007251 D-galactonate transporter; Region: 2A0114; TIGR00893 889933007252 putative substrate translocation pore; other site 889933007253 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 889933007254 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 889933007255 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 889933007256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933007257 Walker A/P-loop; other site 889933007258 ATP binding site [chemical binding]; other site 889933007259 Q-loop/lid; other site 889933007260 ABC transporter signature motif; other site 889933007261 Walker B; other site 889933007262 D-loop; other site 889933007263 H-loop/switch region; other site 889933007264 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 889933007265 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 889933007266 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 889933007267 Uncharacterized membrane protein [Function unknown]; Region: COG3949 889933007268 Predicted esterase [General function prediction only]; Region: COG0400 889933007269 putative hydrolase; Provisional; Region: PRK11460 889933007270 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 889933007271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889933007272 Zn binding site [ion binding]; other site 889933007273 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 889933007274 Zn binding site [ion binding]; other site 889933007275 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889933007276 MarR family; Region: MarR; pfam01047 889933007277 Predicted acetyltransferase [General function prediction only]; Region: COG2388 889933007278 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 889933007279 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 889933007280 putative metal binding site [ion binding]; other site 889933007281 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 889933007282 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 889933007283 dimer interface [polypeptide binding]; other site 889933007284 FMN binding site [chemical binding]; other site 889933007285 D-lactate dehydrogenase; Provisional; Region: PRK12480 889933007286 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 889933007287 homodimer interface [polypeptide binding]; other site 889933007288 ligand binding site [chemical binding]; other site 889933007289 NAD binding site [chemical binding]; other site 889933007290 catalytic site [active] 889933007291 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 889933007292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889933007293 active site 889933007294 motif I; other site 889933007295 motif II; other site 889933007296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 889933007297 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889933007298 Walker A/P-loop; other site 889933007299 ATP binding site [chemical binding]; other site 889933007300 Q-loop/lid; other site 889933007301 ABC transporter signature motif; other site 889933007302 Walker B; other site 889933007303 D-loop; other site 889933007304 H-loop/switch region; other site 889933007305 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 889933007306 active site 889933007307 catalytic site [active] 889933007308 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 889933007309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933007310 Coenzyme A binding pocket [chemical binding]; other site 889933007311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 889933007312 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 889933007313 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 889933007314 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 889933007315 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 889933007316 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 889933007317 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 889933007318 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 889933007319 EamA-like transporter family; Region: EamA; pfam00892 889933007320 EamA-like transporter family; Region: EamA; pfam00892 889933007321 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 889933007322 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 889933007323 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889933007324 catalytic residues [active] 889933007325 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 889933007326 active site 889933007327 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 889933007328 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 889933007329 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889933007330 active site turn [active] 889933007331 phosphorylation site [posttranslational modification] 889933007332 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 889933007333 HPr interaction site; other site 889933007334 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889933007335 active site 889933007336 phosphorylation site [posttranslational modification] 889933007337 pyruvate oxidase; Provisional; Region: PRK08611 889933007338 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 889933007339 PYR/PP interface [polypeptide binding]; other site 889933007340 tetramer interface [polypeptide binding]; other site 889933007341 dimer interface [polypeptide binding]; other site 889933007342 TPP binding site [chemical binding]; other site 889933007343 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 889933007344 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 889933007345 TPP-binding site [chemical binding]; other site 889933007346 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 889933007347 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 889933007348 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889933007349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 889933007350 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 889933007351 putative dimerization interface [polypeptide binding]; other site 889933007352 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 889933007353 Surface antigen [General function prediction only]; Region: COG3942 889933007354 CHAP domain; Region: CHAP; pfam05257 889933007355 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 889933007356 homodimer interface [polypeptide binding]; other site 889933007357 catalytic residues [active] 889933007358 NAD binding site [chemical binding]; other site 889933007359 substrate binding pocket [chemical binding]; other site 889933007360 flexible flap; other site 889933007361 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 889933007362 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 889933007363 dimer interface [polypeptide binding]; other site 889933007364 active site 889933007365 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 889933007366 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 889933007367 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 889933007368 DNA binding site [nucleotide binding] 889933007369 active site 889933007370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933007371 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 889933007372 Walker A motif; other site 889933007373 ATP binding site [chemical binding]; other site 889933007374 Walker B motif; other site 889933007375 arginine finger; other site 889933007376 UvrB/uvrC motif; Region: UVR; pfam02151 889933007377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889933007378 Walker A motif; other site 889933007379 ATP binding site [chemical binding]; other site 889933007380 Walker B motif; other site 889933007381 arginine finger; other site 889933007382 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 889933007383 Virus attachment protein p12 family; Region: P12; pfam12669 889933007384 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 889933007385 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 889933007386 G1 box; other site 889933007387 GTP/Mg2+ binding site [chemical binding]; other site 889933007388 Switch I region; other site 889933007389 G2 box; other site 889933007390 G3 box; other site 889933007391 Switch II region; other site 889933007392 G4 box; other site 889933007393 G5 box; other site 889933007394 Nucleoside recognition; Region: Gate; pfam07670 889933007395 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 889933007396 Nucleoside recognition; Region: Gate; pfam07670 889933007397 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 889933007398 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 889933007399 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 889933007400 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889933007401 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 889933007402 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 889933007403 Glutamate binding site [chemical binding]; other site 889933007404 homodimer interface [polypeptide binding]; other site 889933007405 NAD binding site [chemical binding]; other site 889933007406 catalytic residues [active] 889933007407 maltose O-acetyltransferase; Provisional; Region: PRK10092 889933007408 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 889933007409 active site 889933007410 substrate binding site [chemical binding]; other site 889933007411 trimer interface [polypeptide binding]; other site 889933007412 CoA binding site [chemical binding]; other site 889933007413 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 889933007414 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 889933007415 metal-binding site [ion binding] 889933007416 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 889933007417 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 889933007418 metal-binding site [ion binding] 889933007419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889933007420 Soluble P-type ATPase [General function prediction only]; Region: COG4087 889933007421 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 889933007422 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 889933007423 metal-binding site [ion binding] 889933007424 D-lactate dehydrogenase; Validated; Region: PRK08605 889933007425 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 889933007426 homodimer interface [polypeptide binding]; other site 889933007427 ligand binding site [chemical binding]; other site 889933007428 NAD binding site [chemical binding]; other site 889933007429 catalytic site [active] 889933007430 transaminase; Reviewed; Region: PRK08068 889933007431 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889933007432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933007433 homodimer interface [polypeptide binding]; other site 889933007434 catalytic residue [active] 889933007435 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 889933007436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 889933007437 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 889933007438 active site lid residues [active] 889933007439 substrate binding pocket [chemical binding]; other site 889933007440 catalytic residues [active] 889933007441 substrate-Mg2+ binding site; other site 889933007442 aspartate-rich region 1; other site 889933007443 aspartate-rich region 2; other site 889933007444 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 889933007445 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 889933007446 active site 889933007447 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 889933007448 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 889933007449 Surface antigen [General function prediction only]; Region: COG3942 889933007450 CHAP domain; Region: CHAP; pfam05257 889933007451 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 889933007452 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 889933007453 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 889933007454 catalytic triad [active] 889933007455 catalytic triad [active] 889933007456 oxyanion hole [active] 889933007457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933007458 Coenzyme A binding pocket [chemical binding]; other site 889933007459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889933007460 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889933007461 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 889933007462 N-acetyl-D-glucosamine binding site [chemical binding]; other site 889933007463 catalytic residue [active] 889933007464 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 889933007465 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 889933007466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889933007467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 889933007468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 889933007469 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 889933007470 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889933007471 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 889933007472 NmrA-like family; Region: NmrA; pfam05368 889933007473 NADP binding site [chemical binding]; other site 889933007474 active site 889933007475 regulatory binding site [polypeptide binding]; other site 889933007476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 889933007477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889933007478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 889933007479 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 889933007480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889933007481 NAD(P) binding site [chemical binding]; other site 889933007482 active site 889933007483 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 889933007484 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 889933007485 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 889933007486 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 889933007487 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 889933007488 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 889933007489 Nucleoside recognition; Region: Gate; pfam07670 889933007490 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 889933007491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 889933007492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 889933007493 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 889933007494 Phosphotransferase enzyme family; Region: APH; pfam01636 889933007495 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 889933007496 active site 889933007497 ATP binding site [chemical binding]; other site 889933007498 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 889933007499 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 889933007500 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 889933007501 quinone interaction residues [chemical binding]; other site 889933007502 active site 889933007503 catalytic residues [active] 889933007504 FMN binding site [chemical binding]; other site 889933007505 substrate binding site [chemical binding]; other site 889933007506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 889933007507 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 889933007508 dimer interface [polypeptide binding]; other site 889933007509 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889933007510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889933007511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 889933007512 Predicted acyl esterases [General function prediction only]; Region: COG2936 889933007513 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 889933007514 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 889933007515 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 889933007516 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 889933007517 tetramerization interface [polypeptide binding]; other site 889933007518 active site 889933007519 pantoate--beta-alanine ligase; Region: panC; TIGR00018 889933007520 Pantoate-beta-alanine ligase; Region: PanC; cd00560 889933007521 active site 889933007522 ATP-binding site [chemical binding]; other site 889933007523 pantoate-binding site; other site 889933007524 HXXH motif; other site 889933007525 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 889933007526 oligomerization interface [polypeptide binding]; other site 889933007527 active site 889933007528 metal binding site [ion binding]; metal-binding site 889933007529 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 889933007530 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 889933007531 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 889933007532 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 889933007533 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 889933007534 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 889933007535 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889933007536 NAD binding site [chemical binding]; other site 889933007537 dimer interface [polypeptide binding]; other site 889933007538 substrate binding site [chemical binding]; other site 889933007539 amino acid transporter; Region: 2A0306; TIGR00909 889933007540 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 889933007541 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 889933007542 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889933007543 inhibitor-cofactor binding pocket; inhibition site 889933007544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933007545 catalytic residue [active] 889933007546 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 889933007547 catalytic residue [active] 889933007548 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 889933007549 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 889933007550 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 889933007551 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 889933007552 acyl-activating enzyme (AAE) consensus motif; other site 889933007553 AMP binding site [chemical binding]; other site 889933007554 active site 889933007555 CoA binding site [chemical binding]; other site 889933007556 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 889933007557 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 889933007558 choline dehydrogenase; Validated; Region: PRK02106 889933007559 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 889933007560 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 889933007561 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 889933007562 tetramerization interface [polypeptide binding]; other site 889933007563 NAD(P) binding site [chemical binding]; other site 889933007564 catalytic residues [active] 889933007565 Predicted transcriptional regulators [Transcription]; Region: COG1510 889933007566 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 889933007567 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 889933007568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889933007569 FeS/SAM binding site; other site 889933007570 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 889933007571 Class III ribonucleotide reductase; Region: RNR_III; cd01675 889933007572 effector binding site; other site 889933007573 active site 889933007574 Zn binding site [ion binding]; other site 889933007575 glycine loop; other site 889933007576 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 889933007577 Citrate transporter; Region: CitMHS; pfam03600 889933007578 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 889933007579 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 889933007580 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 889933007581 Flavodoxin; Region: Flavodoxin_1; pfam00258 889933007582 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 889933007583 FAD binding pocket [chemical binding]; other site 889933007584 FAD binding motif [chemical binding]; other site 889933007585 catalytic residues [active] 889933007586 NAD binding pocket [chemical binding]; other site 889933007587 phosphate binding motif [ion binding]; other site 889933007588 beta-alpha-beta structure motif; other site 889933007589 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 889933007590 catalytic residues [active] 889933007591 dimer interface [polypeptide binding]; other site 889933007592 FtsX-like permease family; Region: FtsX; pfam02687 889933007593 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889933007594 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 889933007595 Walker A/P-loop; other site 889933007596 ATP binding site [chemical binding]; other site 889933007597 Q-loop/lid; other site 889933007598 ABC transporter signature motif; other site 889933007599 Walker B; other site 889933007600 D-loop; other site 889933007601 H-loop/switch region; other site 889933007602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 889933007603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889933007604 ATP binding site [chemical binding]; other site 889933007605 Mg2+ binding site [ion binding]; other site 889933007606 G-X-G motif; other site 889933007607 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889933007608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889933007609 active site 889933007610 phosphorylation site [posttranslational modification] 889933007611 intermolecular recognition site; other site 889933007612 dimerization interface [polypeptide binding]; other site 889933007613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889933007614 DNA binding site [nucleotide binding] 889933007615 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 889933007616 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 889933007617 dimer interface [polypeptide binding]; other site 889933007618 active site 889933007619 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 889933007620 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889933007621 MarR family; Region: MarR_2; pfam12802 889933007622 Predicted esterase [General function prediction only]; Region: COG0627 889933007623 S-formylglutathione hydrolase; Region: PLN02442 889933007624 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 889933007625 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 889933007626 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 889933007627 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 889933007628 ligand binding site [chemical binding]; other site 889933007629 flexible hinge region; other site 889933007630 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 889933007631 carbamate kinase; Reviewed; Region: PRK12686 889933007632 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 889933007633 putative substrate binding site [chemical binding]; other site 889933007634 nucleotide binding site [chemical binding]; other site 889933007635 nucleotide binding site [chemical binding]; other site 889933007636 homodimer interface [polypeptide binding]; other site 889933007637 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 889933007638 ornithine carbamoyltransferase; Validated; Region: PRK02102 889933007639 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 889933007640 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 889933007641 arginine deiminase; Provisional; Region: PRK01388 889933007642 Arginine repressor [Transcription]; Region: ArgR; COG1438 889933007643 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 889933007644 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 889933007645 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 889933007646 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 889933007647 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 889933007648 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 889933007649 active site 889933007650 Zn binding site [ion binding]; other site 889933007651 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 889933007652 HTH domain; Region: HTH_11; pfam08279 889933007653 PRD domain; Region: PRD; pfam00874 889933007654 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 889933007655 active site 889933007656 P-loop; other site 889933007657 phosphorylation site [posttranslational modification] 889933007658 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889933007659 active site 889933007660 phosphorylation site [posttranslational modification] 889933007661 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 889933007662 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 889933007663 active site 889933007664 P-loop; other site 889933007665 phosphorylation site [posttranslational modification] 889933007666 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 889933007667 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889933007668 active site 889933007669 phosphorylation site [posttranslational modification] 889933007670 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 889933007671 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 889933007672 Predicted membrane protein [Function unknown]; Region: COG1511 889933007673 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 889933007674 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 889933007675 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 889933007676 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 889933007677 CHAP domain; Region: CHAP; pfam05257 889933007678 Isochorismatase family; Region: Isochorismatase; pfam00857 889933007679 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 889933007680 catalytic triad [active] 889933007681 conserved cis-peptide bond; other site 889933007682 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 889933007683 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 889933007684 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 889933007685 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 889933007686 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 889933007687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 889933007688 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 889933007689 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 889933007690 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 889933007691 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 889933007692 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 889933007693 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 889933007694 SecY translocase; Region: SecY; pfam00344 889933007695 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 889933007696 legume lectins; Region: lectin_L-type; cd01951 889933007697 homotetramer interaction site [polypeptide binding]; other site 889933007698 carbohydrate binding site [chemical binding]; other site 889933007699 metal binding site [ion binding]; metal-binding site 889933007700 Putative Ig domain; Region: He_PIG; pfam05345 889933007701 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 889933007702 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 889933007703 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 889933007704 methionine sulfoxide reductase A; Provisional; Region: PRK05528 889933007705 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 889933007706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889933007707 Coenzyme A binding pocket [chemical binding]; other site 889933007708 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 889933007709 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 889933007710 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 889933007711 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 889933007712 Chain length determinant protein; Region: Wzz; cl15801 889933007713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889933007714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 889933007715 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 889933007716 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 889933007717 DXD motif; other site 889933007718 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 889933007719 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 889933007720 Acyltransferase family; Region: Acyl_transf_3; pfam01757 889933007721 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 889933007722 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 889933007723 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 889933007724 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 889933007725 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 889933007726 metal binding site [ion binding]; metal-binding site 889933007727 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 889933007728 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 889933007729 substrate binding site [chemical binding]; other site 889933007730 glutamase interaction surface [polypeptide binding]; other site 889933007731 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 889933007732 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 889933007733 catalytic residues [active] 889933007734 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 889933007735 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 889933007736 putative active site [active] 889933007737 oxyanion strand; other site 889933007738 catalytic triad [active] 889933007739 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 889933007740 putative active site pocket [active] 889933007741 4-fold oligomerization interface [polypeptide binding]; other site 889933007742 metal binding residues [ion binding]; metal-binding site 889933007743 3-fold/trimer interface [polypeptide binding]; other site 889933007744 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 889933007745 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889933007746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889933007747 homodimer interface [polypeptide binding]; other site 889933007748 catalytic residue [active] 889933007749 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 889933007750 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 889933007751 NAD binding site [chemical binding]; other site 889933007752 dimerization interface [polypeptide binding]; other site 889933007753 product binding site; other site 889933007754 substrate binding site [chemical binding]; other site 889933007755 zinc binding site [ion binding]; other site 889933007756 catalytic residues [active] 889933007757 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 889933007758 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 889933007759 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 889933007760 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 889933007761 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 889933007762 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 889933007763 putative active site [active] 889933007764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 889933007765 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 889933007766 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889933007767 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 889933007768 Walker A/P-loop; other site 889933007769 ATP binding site [chemical binding]; other site 889933007770 Q-loop/lid; other site 889933007771 ABC transporter signature motif; other site 889933007772 Walker B; other site 889933007773 D-loop; other site 889933007774 H-loop/switch region; other site 889933007775 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 889933007776 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889933007777 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 889933007778 Walker A/P-loop; other site 889933007779 ATP binding site [chemical binding]; other site 889933007780 Q-loop/lid; other site 889933007781 ABC transporter signature motif; other site 889933007782 Walker B; other site 889933007783 D-loop; other site 889933007784 H-loop/switch region; other site 889933007785 hypothetical protein; Provisional; Region: PRK13661 889933007786 Uncharacterized conserved protein [Function unknown]; Region: COG1912 889933007787 Uncharacterized conserved protein [Function unknown]; Region: COG2353 889933007788 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 889933007789 Strictosidine synthase; Region: Str_synth; pfam03088 889933007790 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 889933007791 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 889933007792 active site residue [active] 889933007793 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 889933007794 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 889933007795 putative substrate binding pocket [chemical binding]; other site 889933007796 AC domain interface; other site 889933007797 catalytic triad [active] 889933007798 AB domain interface; other site 889933007799 interchain disulfide; other site 889933007800 Predicted transcriptional regulators [Transcription]; Region: COG1695 889933007801 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 889933007802 DinB superfamily; Region: DinB_2; pfam12867 889933007803 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 889933007804 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 889933007805 transmembrane helices; other site 889933007806 Predicted permeases [General function prediction only]; Region: RarD; COG2962 889933007807 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 889933007808 hypothetical protein; Provisional; Region: PRK07758 889933007809 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 889933007810 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 889933007811 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 889933007812 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889933007813 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 889933007814 Walker A/P-loop; other site 889933007815 ATP binding site [chemical binding]; other site 889933007816 Q-loop/lid; other site 889933007817 ABC transporter signature motif; other site 889933007818 Walker B; other site 889933007819 D-loop; other site 889933007820 H-loop/switch region; other site 889933007821 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 889933007822 FtsX-like permease family; Region: FtsX; pfam02687 889933007823 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 889933007824 DNA-binding site [nucleotide binding]; DNA binding site 889933007825 RNA-binding motif; other site 889933007826 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 889933007827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889933007828 non-specific DNA binding site [nucleotide binding]; other site 889933007829 salt bridge; other site 889933007830 sequence-specific DNA binding site [nucleotide binding]; other site 889933007831 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 889933007832 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 889933007833 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 889933007834 ParB-like nuclease domain; Region: ParBc; pfam02195 889933007835 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 889933007836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889933007837 S-adenosylmethionine binding site [chemical binding]; other site 889933007838 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 889933007839 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 889933007840 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 889933007841 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 889933007842 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 889933007843 trmE is a tRNA modification GTPase; Region: trmE; cd04164 889933007844 G1 box; other site 889933007845 GTP/Mg2+ binding site [chemical binding]; other site 889933007846 Switch I region; other site 889933007847 G2 box; other site 889933007848 Switch II region; other site 889933007849 G3 box; other site 889933007850 G4 box; other site 889933007851 G5 box; other site 889933007852 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 889933007853 ribonuclease P; Reviewed; Region: rnpA; PRK00499 889933007854 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 889933007855 Replication protein; Region: Rep_1; cl02412 889933007856 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889933007857 putative DNA binding site [nucleotide binding]; other site 889933007858 putative Zn2+ binding site [ion binding]; other site 889933007859 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 889933007860 Cadmium resistance transporter; Region: Cad; pfam03596 889933007861 Replication protein; Region: Rep_1; cl02412 889933007862 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 889933007863 Replication protein; Region: Rep_1; pfam01446 889933007864 Replication protein; Region: Rep_1; cl02412 889933007865 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 889933007866 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933007867 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933007868 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933007869 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933007870 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 889933007871 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 889933007872 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 889933007873 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 889933007874 NADP binding site [chemical binding]; other site 889933007875 dimer interface [polypeptide binding]; other site 889933007876 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889933007877 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 889933007878 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 889933007879 catalytic residues [active] 889933007880 catalytic nucleophile [active] 889933007881 Presynaptic Site I dimer interface [polypeptide binding]; other site 889933007882 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 889933007883 Synaptic Flat tetramer interface [polypeptide binding]; other site 889933007884 Synaptic Site I dimer interface [polypeptide binding]; other site 889933007885 DNA binding site [nucleotide binding] 889933007886 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 889933007887 DNA-binding interface [nucleotide binding]; DNA binding site 889933007888 multiple promoter invertase; Provisional; Region: mpi; PRK13413 889933007889 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 889933007890 catalytic residues [active] 889933007891 catalytic nucleophile [active] 889933007892 Presynaptic Site I dimer interface [polypeptide binding]; other site 889933007893 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 889933007894 Synaptic Flat tetramer interface [polypeptide binding]; other site 889933007895 Synaptic Site I dimer interface [polypeptide binding]; other site 889933007896 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 889933007897 DNA-binding interface [nucleotide binding]; DNA binding site 889933007898 Predicted transcriptional regulator [Transcription]; Region: COG3682 889933007899 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 889933007900 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 889933007901 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 889933007902 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 889933007903 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 889933007904 potential frameshift: common BLAST hit: gi|379793825|ref|YP_005327054.1| putative reverse transcriptase 889933007905 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 889933007906 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 889933007907 NTP binding site [chemical binding]; other site 889933007908 Replication protein; Region: Rep_1; pfam01446