-- dump date 20140620_073646 -- class Genbank::misc_feature -- table misc_feature_note -- id note 685039000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 685039000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 685039000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039000004 Walker A motif; other site 685039000005 ATP binding site [chemical binding]; other site 685039000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 685039000007 Walker B motif; other site 685039000008 arginine finger; other site 685039000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 685039000010 DnaA box-binding interface [nucleotide binding]; other site 685039000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 685039000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 685039000013 putative DNA binding surface [nucleotide binding]; other site 685039000014 dimer interface [polypeptide binding]; other site 685039000015 beta-clamp/clamp loader binding surface; other site 685039000016 beta-clamp/translesion DNA polymerase binding surface; other site 685039000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 685039000018 recF protein; Region: recf; TIGR00611 685039000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 685039000020 Walker A/P-loop; other site 685039000021 ATP binding site [chemical binding]; other site 685039000022 Q-loop/lid; other site 685039000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039000024 ABC transporter signature motif; other site 685039000025 Walker B; other site 685039000026 D-loop; other site 685039000027 H-loop/switch region; other site 685039000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 685039000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039000030 Mg2+ binding site [ion binding]; other site 685039000031 G-X-G motif; other site 685039000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 685039000033 anchoring element; other site 685039000034 dimer interface [polypeptide binding]; other site 685039000035 ATP binding site [chemical binding]; other site 685039000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 685039000037 active site 685039000038 putative metal-binding site [ion binding]; other site 685039000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 685039000040 DNA gyrase subunit A; Validated; Region: PRK05560 685039000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 685039000042 CAP-like domain; other site 685039000043 active site 685039000044 primary dimer interface [polypeptide binding]; other site 685039000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685039000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685039000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685039000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685039000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685039000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685039000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 685039000052 putative substrate binding site [chemical binding]; other site 685039000053 putative ATP binding site [chemical binding]; other site 685039000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 685039000055 active sites [active] 685039000056 tetramer interface [polypeptide binding]; other site 685039000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 685039000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 685039000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 685039000060 dimer interface [polypeptide binding]; other site 685039000061 active site 685039000062 motif 1; other site 685039000063 motif 2; other site 685039000064 motif 3; other site 685039000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 685039000066 Predicted membrane protein [Function unknown]; Region: COG4392 685039000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 685039000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685039000069 Predicted membrane protein [Function unknown]; Region: COG4241 685039000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 685039000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 685039000072 DHH family; Region: DHH; pfam01368 685039000073 DHHA1 domain; Region: DHHA1; pfam02272 685039000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 685039000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 685039000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 685039000077 replicative DNA helicase; Region: DnaB; TIGR00665 685039000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 685039000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 685039000080 Walker A motif; other site 685039000081 ATP binding site [chemical binding]; other site 685039000082 Walker B motif; other site 685039000083 DNA binding loops [nucleotide binding] 685039000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 685039000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 685039000086 GDP-binding site [chemical binding]; other site 685039000087 ACT binding site; other site 685039000088 IMP binding site; other site 685039000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685039000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039000091 active site 685039000092 phosphorylation site [posttranslational modification] 685039000093 intermolecular recognition site; other site 685039000094 dimerization interface [polypeptide binding]; other site 685039000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685039000096 DNA binding site [nucleotide binding] 685039000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 685039000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685039000099 dimerization interface [polypeptide binding]; other site 685039000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 685039000101 putative active site [active] 685039000102 heme pocket [chemical binding]; other site 685039000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685039000104 dimer interface [polypeptide binding]; other site 685039000105 phosphorylation site [posttranslational modification] 685039000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039000107 ATP binding site [chemical binding]; other site 685039000108 Mg2+ binding site [ion binding]; other site 685039000109 G-X-G motif; other site 685039000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 685039000111 YycH protein; Region: YycH; pfam07435 685039000112 YycH protein; Region: YycI; cl02015 685039000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 685039000114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 685039000115 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 685039000116 putative active site [active] 685039000117 putative metal binding site [ion binding]; other site 685039000118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 685039000119 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 685039000120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039000121 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 685039000122 Walker A motif; other site 685039000123 ATP binding site [chemical binding]; other site 685039000124 Walker B motif; other site 685039000125 Family description; Region: UvrD_C_2; pfam13538 685039000126 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 685039000127 Transposase; Region: HTH_Tnp_1; cl17663 685039000128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039000129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039000130 Helix-turn-helix domain; Region: HTH_28; pfam13518 685039000131 HTH-like domain; Region: HTH_21; pfam13276 685039000132 Integrase core domain; Region: rve; pfam00665 685039000133 Integrase core domain; Region: rve_3; cl15866 685039000134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 685039000135 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 685039000136 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 685039000137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 685039000138 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 685039000139 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685039000140 phosphate binding site [ion binding]; other site 685039000141 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 685039000142 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 685039000143 putative homodimer interface [polypeptide binding]; other site 685039000144 putative homotetramer interface [polypeptide binding]; other site 685039000145 putative metal binding site [ion binding]; other site 685039000146 putative homodimer-homodimer interface [polypeptide binding]; other site 685039000147 putative allosteric switch controlling residues; other site 685039000148 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685039000149 active site residue [active] 685039000150 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 685039000151 CPxP motif; other site 685039000152 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 685039000153 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 685039000154 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 685039000155 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685039000156 active site residue [active] 685039000157 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 685039000158 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 685039000159 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 685039000160 FMN binding site [chemical binding]; other site 685039000161 active site 685039000162 catalytic residues [active] 685039000163 substrate binding site [chemical binding]; other site 685039000164 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 685039000165 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 685039000166 Part of AAA domain; Region: AAA_19; pfam13245 685039000167 AAA domain; Region: AAA_12; pfam13087 685039000168 HTH-like domain; Region: HTH_21; pfam13276 685039000169 Integrase core domain; Region: rve; pfam00665 685039000170 Integrase core domain; Region: rve_3; cl15866 685039000171 Transposase; Region: HTH_Tnp_1; cl17663 685039000172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039000173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039000174 Helix-turn-helix domain; Region: HTH_28; pfam13518 685039000175 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 685039000176 active site 685039000177 catalytic site [active] 685039000178 putative metal binding site [ion binding]; other site 685039000179 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 685039000180 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685039000181 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 685039000182 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 685039000183 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 685039000184 metal binding site [ion binding]; metal-binding site 685039000185 dimer interface [polypeptide binding]; other site 685039000186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039000187 putative transporter; Provisional; Region: PRK10504 685039000188 putative substrate translocation pore; other site 685039000189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039000190 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 685039000191 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 685039000192 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 685039000193 PhoU domain; Region: PhoU; pfam01895 685039000194 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 685039000195 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 685039000196 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 685039000197 L-lactate permease; Region: Lactate_perm; cl00701 685039000198 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 685039000199 B domain; Region: B; pfam02216 685039000200 B domain; Region: B; pfam02216 685039000201 B domain; Region: B; pfam02216 685039000202 B domain; Region: B; pfam02216 685039000203 B domain; Region: B; pfam02216 685039000204 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 685039000205 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685039000206 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 685039000207 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685039000208 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 685039000209 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685039000210 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685039000211 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039000212 ABC-ATPase subunit interface; other site 685039000213 dimer interface [polypeptide binding]; other site 685039000214 putative PBP binding regions; other site 685039000215 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685039000216 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039000217 ABC-ATPase subunit interface; other site 685039000218 dimer interface [polypeptide binding]; other site 685039000219 putative PBP binding regions; other site 685039000220 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685039000221 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685039000222 siderophore binding site; other site 685039000223 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 685039000224 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 685039000225 dimer interface [polypeptide binding]; other site 685039000226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039000227 catalytic residue [active] 685039000228 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 685039000229 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 685039000230 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 685039000231 IucA / IucC family; Region: IucA_IucC; pfam04183 685039000232 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 685039000233 drug efflux system protein MdtG; Provisional; Region: PRK09874 685039000234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039000235 putative substrate translocation pore; other site 685039000236 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 685039000237 IucA / IucC family; Region: IucA_IucC; pfam04183 685039000238 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 685039000239 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 685039000240 IucA / IucC family; Region: IucA_IucC; pfam04183 685039000241 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 685039000242 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 685039000243 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 685039000244 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 685039000245 dimer interface [polypeptide binding]; other site 685039000246 active site 685039000247 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685039000248 catalytic residues [active] 685039000249 substrate binding site [chemical binding]; other site 685039000250 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 685039000251 ParB-like nuclease domain; Region: ParBc; pfam02195 685039000252 acetoin reductase; Validated; Region: PRK08643 685039000253 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 685039000254 NAD binding site [chemical binding]; other site 685039000255 homotetramer interface [polypeptide binding]; other site 685039000256 homodimer interface [polypeptide binding]; other site 685039000257 active site 685039000258 substrate binding site [chemical binding]; other site 685039000259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685039000260 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 685039000261 NAD(P) binding site [chemical binding]; other site 685039000262 active site 685039000263 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 685039000264 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 685039000265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 685039000266 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 685039000267 putative ADP-binding pocket [chemical binding]; other site 685039000268 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 685039000269 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 685039000270 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 685039000271 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 685039000272 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 685039000273 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 685039000274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685039000275 DNA-binding site [nucleotide binding]; DNA binding site 685039000276 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 685039000277 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 685039000278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039000279 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 685039000280 intersubunit interface [polypeptide binding]; other site 685039000281 active site 685039000282 catalytic residue [active] 685039000283 phosphopentomutase; Provisional; Region: PRK05362 685039000284 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 685039000285 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 685039000286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039000287 dimer interface [polypeptide binding]; other site 685039000288 conserved gate region; other site 685039000289 putative PBP binding loops; other site 685039000290 ABC-ATPase subunit interface; other site 685039000291 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 685039000292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039000293 dimer interface [polypeptide binding]; other site 685039000294 conserved gate region; other site 685039000295 ABC-ATPase subunit interface; other site 685039000296 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 685039000297 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 685039000298 Walker A/P-loop; other site 685039000299 ATP binding site [chemical binding]; other site 685039000300 Q-loop/lid; other site 685039000301 ABC transporter signature motif; other site 685039000302 Walker B; other site 685039000303 D-loop; other site 685039000304 H-loop/switch region; other site 685039000305 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 685039000306 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 685039000307 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 685039000308 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 685039000309 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 685039000310 active site 685039000311 metal binding site [ion binding]; metal-binding site 685039000312 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 685039000313 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685039000314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039000315 non-specific DNA binding site [nucleotide binding]; other site 685039000316 salt bridge; other site 685039000317 sequence-specific DNA binding site [nucleotide binding]; other site 685039000318 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 685039000319 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 685039000320 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 685039000321 putative catalytic cysteine [active] 685039000322 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 685039000323 putative active site [active] 685039000324 metal binding site [ion binding]; metal-binding site 685039000325 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 685039000326 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 685039000327 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 685039000328 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685039000329 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 685039000330 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 685039000331 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 685039000332 NAD(P) binding site [chemical binding]; other site 685039000333 homodimer interface [polypeptide binding]; other site 685039000334 substrate binding site [chemical binding]; other site 685039000335 active site 685039000336 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 685039000337 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 685039000338 NAD(P) binding site [chemical binding]; other site 685039000339 homodimer interface [polypeptide binding]; other site 685039000340 substrate binding site [chemical binding]; other site 685039000341 active site 685039000342 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 685039000343 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 685039000344 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 685039000345 putative NAD(P) binding site [chemical binding]; other site 685039000346 active site 685039000347 putative substrate binding site [chemical binding]; other site 685039000348 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 685039000349 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 685039000350 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 685039000351 active site 685039000352 homodimer interface [polypeptide binding]; other site 685039000353 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 685039000354 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 685039000355 trimer interface [polypeptide binding]; other site 685039000356 active site 685039000357 substrate binding site [chemical binding]; other site 685039000358 CoA binding site [chemical binding]; other site 685039000359 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 685039000360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 685039000361 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 685039000362 Bacterial sugar transferase; Region: Bac_transf; pfam02397 685039000363 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 685039000364 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 685039000365 putative NAD(P) binding site [chemical binding]; other site 685039000366 active site 685039000367 putative substrate binding site [chemical binding]; other site 685039000368 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 685039000369 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 685039000370 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 685039000371 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 685039000372 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 685039000373 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 685039000374 active site 685039000375 homodimer interface [polypeptide binding]; other site 685039000376 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 685039000377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 685039000378 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 685039000379 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 685039000380 NAD(P) binding site [chemical binding]; other site 685039000381 catalytic residues [active] 685039000382 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 685039000383 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 685039000384 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 685039000385 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 685039000386 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 685039000387 Walker A/P-loop; other site 685039000388 ATP binding site [chemical binding]; other site 685039000389 Q-loop/lid; other site 685039000390 ABC transporter signature motif; other site 685039000391 Walker B; other site 685039000392 D-loop; other site 685039000393 H-loop/switch region; other site 685039000394 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 685039000395 NMT1-like family; Region: NMT1_2; pfam13379 685039000396 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685039000397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 685039000398 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685039000399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685039000400 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039000401 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 685039000402 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685039000403 acyl-activating enzyme (AAE) consensus motif; other site 685039000404 AMP binding site [chemical binding]; other site 685039000405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685039000406 Condensation domain; Region: Condensation; pfam00668 685039000407 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685039000408 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685039000409 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685039000410 acyl-activating enzyme (AAE) consensus motif; other site 685039000411 AMP binding site [chemical binding]; other site 685039000412 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685039000413 thioester reductase domain; Region: Thioester-redct; TIGR01746 685039000414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685039000415 NAD(P) binding site [chemical binding]; other site 685039000416 active site 685039000417 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 685039000418 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 685039000419 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 685039000420 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 685039000421 nucleotide binding site [chemical binding]; other site 685039000422 N-acetyl-L-glutamate binding site [chemical binding]; other site 685039000423 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 685039000424 heterotetramer interface [polypeptide binding]; other site 685039000425 active site pocket [active] 685039000426 cleavage site 685039000427 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 685039000428 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 685039000429 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 685039000430 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685039000431 inhibitor-cofactor binding pocket; inhibition site 685039000432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039000433 catalytic residue [active] 685039000434 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 685039000435 Isochorismatase family; Region: Isochorismatase; pfam00857 685039000436 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 685039000437 catalytic triad [active] 685039000438 conserved cis-peptide bond; other site 685039000439 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 685039000440 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 685039000441 dimer interface [polypeptide binding]; other site 685039000442 PYR/PP interface [polypeptide binding]; other site 685039000443 TPP binding site [chemical binding]; other site 685039000444 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685039000445 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 685039000446 TPP-binding site [chemical binding]; other site 685039000447 dimer interface [polypeptide binding]; other site 685039000448 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 685039000449 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685039000450 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685039000451 active site turn [active] 685039000452 phosphorylation site [posttranslational modification] 685039000453 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 685039000454 HPr interaction site; other site 685039000455 glycerol kinase (GK) interaction site [polypeptide binding]; other site 685039000456 active site 685039000457 phosphorylation site [posttranslational modification] 685039000458 Uncharacterized conserved protein [Function unknown]; Region: COG3589 685039000459 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 685039000460 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 685039000461 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 685039000462 putative active site [active] 685039000463 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 685039000464 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685039000465 active site turn [active] 685039000466 phosphorylation site [posttranslational modification] 685039000467 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685039000468 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 685039000469 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 685039000470 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 685039000471 putative active site [active] 685039000472 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 685039000473 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 685039000474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685039000475 ATP binding site [chemical binding]; other site 685039000476 putative Mg++ binding site [ion binding]; other site 685039000477 RES domain; Region: RES; pfam08808 685039000478 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 685039000479 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685039000480 Walker A/P-loop; other site 685039000481 ATP binding site [chemical binding]; other site 685039000482 Q-loop/lid; other site 685039000483 ABC transporter signature motif; other site 685039000484 Walker B; other site 685039000485 D-loop; other site 685039000486 H-loop/switch region; other site 685039000487 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 685039000488 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685039000489 Walker A/P-loop; other site 685039000490 ATP binding site [chemical binding]; other site 685039000491 Q-loop/lid; other site 685039000492 ABC transporter signature motif; other site 685039000493 Walker B; other site 685039000494 D-loop; other site 685039000495 H-loop/switch region; other site 685039000496 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685039000497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039000498 dimer interface [polypeptide binding]; other site 685039000499 conserved gate region; other site 685039000500 putative PBP binding loops; other site 685039000501 ABC-ATPase subunit interface; other site 685039000502 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 685039000503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039000504 dimer interface [polypeptide binding]; other site 685039000505 conserved gate region; other site 685039000506 ABC-ATPase subunit interface; other site 685039000507 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 685039000508 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 685039000509 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 685039000510 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 685039000511 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 685039000512 azoreductase; Reviewed; Region: PRK00170 685039000513 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 685039000514 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 685039000515 Peptidase family M23; Region: Peptidase_M23; pfam01551 685039000516 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 685039000517 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 685039000518 Walker A/P-loop; other site 685039000519 ATP binding site [chemical binding]; other site 685039000520 Q-loop/lid; other site 685039000521 ABC transporter signature motif; other site 685039000522 Walker B; other site 685039000523 D-loop; other site 685039000524 H-loop/switch region; other site 685039000525 TOBE domain; Region: TOBE; pfam03459 685039000526 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 685039000527 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 685039000528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039000529 dimer interface [polypeptide binding]; other site 685039000530 conserved gate region; other site 685039000531 ABC-ATPase subunit interface; other site 685039000532 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 685039000533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039000534 dimer interface [polypeptide binding]; other site 685039000535 conserved gate region; other site 685039000536 putative PBP binding loops; other site 685039000537 ABC-ATPase subunit interface; other site 685039000538 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 685039000539 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 685039000540 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 685039000541 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 685039000542 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 685039000543 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 685039000544 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 685039000545 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685039000546 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 685039000547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 685039000548 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 685039000549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039000550 putative substrate translocation pore; other site 685039000551 Response regulator receiver domain; Region: Response_reg; pfam00072 685039000552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039000553 active site 685039000554 phosphorylation site [posttranslational modification] 685039000555 intermolecular recognition site; other site 685039000556 dimerization interface [polypeptide binding]; other site 685039000557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685039000558 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685039000559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685039000560 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 685039000561 Histidine kinase; Region: His_kinase; pfam06580 685039000562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039000563 ATP binding site [chemical binding]; other site 685039000564 Mg2+ binding site [ion binding]; other site 685039000565 G-X-G motif; other site 685039000566 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 685039000567 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 685039000568 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 685039000569 Pyruvate formate lyase 1; Region: PFL1; cd01678 685039000570 coenzyme A binding site [chemical binding]; other site 685039000571 active site 685039000572 catalytic residues [active] 685039000573 glycine loop; other site 685039000574 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 685039000575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685039000576 FeS/SAM binding site; other site 685039000577 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 685039000578 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 685039000579 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 685039000580 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 685039000581 putative active site [active] 685039000582 catalytic site [active] 685039000583 putative metal binding site [ion binding]; other site 685039000584 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 685039000585 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 685039000586 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 685039000587 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 685039000588 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 685039000589 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 685039000590 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 685039000591 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 685039000592 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 685039000593 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 685039000594 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 685039000595 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685039000596 dimer interface [polypeptide binding]; other site 685039000597 active site 685039000598 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 685039000599 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 685039000600 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 685039000601 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 685039000602 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685039000603 substrate binding site [chemical binding]; other site 685039000604 oxyanion hole (OAH) forming residues; other site 685039000605 trimer interface [polypeptide binding]; other site 685039000606 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685039000607 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685039000608 active site 685039000609 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685039000610 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685039000611 acyl-activating enzyme (AAE) consensus motif; other site 685039000612 AMP binding site [chemical binding]; other site 685039000613 active site 685039000614 CoA binding site [chemical binding]; other site 685039000615 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 685039000616 Coenzyme A transferase; Region: CoA_trans; smart00882 685039000617 Coenzyme A transferase; Region: CoA_trans; cl17247 685039000618 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 685039000619 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 685039000620 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 685039000621 Uncharacterized conserved protein [Function unknown]; Region: COG3189 685039000622 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 685039000623 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 685039000624 heme-binding site [chemical binding]; other site 685039000625 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 685039000626 FAD binding pocket [chemical binding]; other site 685039000627 FAD binding motif [chemical binding]; other site 685039000628 phosphate binding motif [ion binding]; other site 685039000629 beta-alpha-beta structure motif; other site 685039000630 NAD binding pocket [chemical binding]; other site 685039000631 Heme binding pocket [chemical binding]; other site 685039000632 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 685039000633 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 685039000634 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685039000635 NAD binding site [chemical binding]; other site 685039000636 dimer interface [polypeptide binding]; other site 685039000637 substrate binding site [chemical binding]; other site 685039000638 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 685039000639 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685039000640 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685039000641 active site turn [active] 685039000642 phosphorylation site [posttranslational modification] 685039000643 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 685039000644 active site 685039000645 tetramer interface [polypeptide binding]; other site 685039000646 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 685039000647 Mga helix-turn-helix domain; Region: Mga; pfam05043 685039000648 PRD domain; Region: PRD; pfam00874 685039000649 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 685039000650 active site 685039000651 P-loop; other site 685039000652 phosphorylation site [posttranslational modification] 685039000653 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685039000654 active site 685039000655 phosphorylation site [posttranslational modification] 685039000656 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685039000657 active site 685039000658 phosphorylation site [posttranslational modification] 685039000659 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 685039000660 active site 685039000661 P-loop; other site 685039000662 phosphorylation site [posttranslational modification] 685039000663 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 685039000664 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 685039000665 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685039000666 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 685039000667 putative NAD(P) binding site [chemical binding]; other site 685039000668 catalytic Zn binding site [ion binding]; other site 685039000669 structural Zn binding site [ion binding]; other site 685039000670 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685039000671 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 685039000672 putative NAD(P) binding site [chemical binding]; other site 685039000673 catalytic Zn binding site [ion binding]; other site 685039000674 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 685039000675 substrate binding site; other site 685039000676 dimer interface; other site 685039000677 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 685039000678 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685039000679 putative NAD(P) binding site [chemical binding]; other site 685039000680 putative catalytic Zn binding site [ion binding]; other site 685039000681 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 685039000682 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 685039000683 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 685039000684 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 685039000685 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 685039000686 substrate binding site; other site 685039000687 dimer interface; other site 685039000688 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 685039000689 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685039000690 putative NAD(P) binding site [chemical binding]; other site 685039000691 putative catalytic Zn binding site [ion binding]; other site 685039000692 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 685039000693 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 685039000694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 685039000695 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 685039000696 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 685039000697 Hemerythrin-like domain; Region: Hr-like; cd12108 685039000698 Fe binding site [ion binding]; other site 685039000699 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 685039000700 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 685039000701 Histidine kinase; Region: His_kinase; pfam06580 685039000702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039000703 Mg2+ binding site [ion binding]; other site 685039000704 G-X-G motif; other site 685039000705 two-component response regulator; Provisional; Region: PRK14084 685039000706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039000707 active site 685039000708 phosphorylation site [posttranslational modification] 685039000709 intermolecular recognition site; other site 685039000710 dimerization interface [polypeptide binding]; other site 685039000711 LytTr DNA-binding domain; Region: LytTR; pfam04397 685039000712 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 685039000713 antiholin-like protein LrgB; Provisional; Region: PRK04288 685039000714 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 685039000715 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 685039000716 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 685039000717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685039000718 DNA-binding site [nucleotide binding]; DNA binding site 685039000719 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 685039000720 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 685039000721 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 685039000722 HPr interaction site; other site 685039000723 glycerol kinase (GK) interaction site [polypeptide binding]; other site 685039000724 active site 685039000725 phosphorylation site [posttranslational modification] 685039000726 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 685039000727 beta-galactosidase; Region: BGL; TIGR03356 685039000728 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685039000729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039000730 S-adenosylmethionine binding site [chemical binding]; other site 685039000731 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 685039000732 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 685039000733 substrate binding site [chemical binding]; other site 685039000734 dimer interface [polypeptide binding]; other site 685039000735 ATP binding site [chemical binding]; other site 685039000736 D-ribose pyranase; Provisional; Region: PRK11797 685039000737 Sugar transport protein; Region: Sugar_transport; pfam06800 685039000738 Transcriptional regulators [Transcription]; Region: PurR; COG1609 685039000739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685039000740 DNA binding site [nucleotide binding] 685039000741 domain linker motif; other site 685039000742 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 685039000743 dimerization interface [polypeptide binding]; other site 685039000744 ligand binding site [chemical binding]; other site 685039000745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039000746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039000747 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 685039000748 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 685039000749 active site 685039000750 Surface antigen [General function prediction only]; Region: COG3942 685039000751 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 685039000752 Peptidase family M23; Region: Peptidase_M23; pfam01551 685039000753 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685039000754 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 685039000755 Walker A/P-loop; other site 685039000756 ATP binding site [chemical binding]; other site 685039000757 Q-loop/lid; other site 685039000758 ABC transporter signature motif; other site 685039000759 Walker B; other site 685039000760 D-loop; other site 685039000761 H-loop/switch region; other site 685039000762 Surface antigen [General function prediction only]; Region: COG3942 685039000763 CHAP domain; Region: CHAP; pfam05257 685039000764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 685039000765 Predicted membrane protein [Function unknown]; Region: COG1511 685039000766 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 685039000767 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 685039000768 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 685039000769 Uncharacterized small protein [Function unknown]; Region: COG5417 685039000770 Predicted membrane protein [Function unknown]; Region: COG4499 685039000771 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 685039000772 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 685039000773 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 685039000774 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685039000775 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685039000776 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 685039000777 Uncharacterized conserved protein [Function unknown]; Region: COG5444 685039000778 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 685039000779 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 685039000780 Protein of unknown function, DUF600; Region: DUF600; cl04640 685039000781 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 685039000782 Protein of unknown function, DUF600; Region: DUF600; cl04640 685039000783 Protein of unknown function, DUF600; Region: DUF600; cl04640 685039000784 Protein of unknown function, DUF600; Region: DUF600; cl04640 685039000785 Protein of unknown function, DUF600; Region: DUF600; cl04640 685039000786 Protein of unknown function, DUF600; Region: DUF600; cl04640 685039000787 Protein of unknown function, DUF600; Region: DUF600; cl04640 685039000788 Protein of unknown function, DUF600; Region: DUF600; cl04640 685039000789 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 685039000790 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 685039000791 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 685039000792 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685039000793 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 685039000794 FtsX-like permease family; Region: FtsX; pfam02687 685039000795 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685039000796 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685039000797 Walker A/P-loop; other site 685039000798 ATP binding site [chemical binding]; other site 685039000799 Q-loop/lid; other site 685039000800 ABC transporter signature motif; other site 685039000801 Walker B; other site 685039000802 D-loop; other site 685039000803 H-loop/switch region; other site 685039000804 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 685039000805 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 685039000806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039000807 non-specific DNA binding site [nucleotide binding]; other site 685039000808 salt bridge; other site 685039000809 sequence-specific DNA binding site [nucleotide binding]; other site 685039000810 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 685039000811 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 685039000812 substrate binding site [chemical binding]; other site 685039000813 ATP binding site [chemical binding]; other site 685039000814 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 685039000815 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 685039000816 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 685039000817 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 685039000818 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 685039000819 putative transporter; Provisional; Region: PRK10484 685039000820 Na binding site [ion binding]; other site 685039000821 N-acetylneuraminate lyase; Provisional; Region: PRK04147 685039000822 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 685039000823 inhibitor site; inhibition site 685039000824 active site 685039000825 dimer interface [polypeptide binding]; other site 685039000826 catalytic residue [active] 685039000827 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685039000828 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685039000829 nucleotide binding site [chemical binding]; other site 685039000830 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 685039000831 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 685039000832 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 685039000833 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 685039000834 putative active site [active] 685039000835 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 685039000836 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 685039000837 putative active site cavity [active] 685039000838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 685039000839 Nucleoside recognition; Region: Gate; pfam07670 685039000840 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 685039000841 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 685039000842 PGAP1-like protein; Region: PGAP1; pfam07819 685039000843 probable integrated prophage, phiSaov1 685039000844 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 685039000845 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 685039000846 Int/Topo IB signature motif; other site 685039000847 CAAX protease self-immunity; Region: Abi; pfam02517 685039000848 Domain of unknown function (DUF955); Region: DUF955; cl01076 685039000849 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685039000850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039000851 non-specific DNA binding site [nucleotide binding]; other site 685039000852 salt bridge; other site 685039000853 sequence-specific DNA binding site [nucleotide binding]; other site 685039000854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039000855 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685039000856 non-specific DNA binding site [nucleotide binding]; other site 685039000857 salt bridge; other site 685039000858 sequence-specific DNA binding site [nucleotide binding]; other site 685039000859 Phage anti-repressor protein [Transcription]; Region: COG3561 685039000860 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 685039000861 Homeodomain-like domain; Region: HTH_23; pfam13384 685039000862 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 685039000863 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 685039000864 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 685039000865 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 685039000866 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 685039000867 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685039000868 dimer interface [polypeptide binding]; other site 685039000869 ssDNA binding site [nucleotide binding]; other site 685039000870 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685039000871 Protein of unknown function (DUF968); Region: DUF968; pfam06147 685039000872 phage replisome organizer, putative, N-terminal region; Region: phage_rep_org_N; TIGR01714 685039000873 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 685039000874 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 685039000875 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 685039000876 Walker A motif; other site 685039000877 ATP binding site [chemical binding]; other site 685039000878 Walker B motif; other site 685039000879 DNA binding loops [nucleotide binding] 685039000880 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 685039000881 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 685039000882 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 685039000883 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685039000884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039000885 non-specific DNA binding site [nucleotide binding]; other site 685039000886 salt bridge; other site 685039000887 sequence-specific DNA binding site [nucleotide binding]; other site 685039000888 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 685039000889 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 685039000890 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 685039000891 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 685039000892 active site 685039000893 homodimer interface [polypeptide binding]; other site 685039000894 dUTPase; Region: dUTPase_2; pfam08761 685039000895 metal binding site [ion binding]; metal-binding site 685039000896 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 685039000897 Transcriptional activator RinB; Region: RinB; pfam06116 685039000898 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 685039000899 Virulence-associated protein E; Region: VirE; pfam05272 685039000900 VRR-NUC domain; Region: VRR_NUC; pfam08774 685039000901 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 685039000902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685039000903 ATP binding site [chemical binding]; other site 685039000904 putative Mg++ binding site [ion binding]; other site 685039000905 helicase superfamily c-terminal domain; Region: HELICc; smart00490 685039000906 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 685039000907 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 685039000908 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685039000909 active site 685039000910 Phage terminase, small subunit; Region: Terminase_4; pfam05119 685039000911 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 685039000912 Phage-related protein [Function unknown]; Region: COG4695; cl01923 685039000913 Clp protease; Region: CLP_protease; pfam00574 685039000914 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 685039000915 oligomer interface [polypeptide binding]; other site 685039000916 active site residues [active] 685039000917 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 685039000918 Phage capsid family; Region: Phage_capsid; pfam05065 685039000919 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 685039000920 oligomerization interface [polypeptide binding]; other site 685039000921 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 685039000922 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 685039000923 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 685039000924 potential frameshift: common BLAST hit: gi|150393559|ref|YP_001316234.1| TP901 family phage tail tape measure protein 685039000925 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 685039000926 linker region; other site 685039000927 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 685039000928 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 685039000929 Peptidase family M23; Region: Peptidase_M23; pfam01551 685039000930 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685039000931 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685039000932 catalytic residue [active] 685039000933 Phage tail protein; Region: Sipho_tail; pfam05709 685039000934 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 685039000935 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 685039000936 hypothetical protein; Provisional; Region: PRK05926 685039000937 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 685039000938 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 685039000939 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 685039000940 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 685039000941 holin, SPP1 family; Region: holin_SPP1; TIGR01592 685039000942 CHAP domain; Region: CHAP; pfam05257 685039000943 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 685039000944 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 685039000945 active site 685039000946 metal binding site [ion binding]; metal-binding site 685039000947 Bacterial SH3 domain; Region: SH3_5; pfam08460 685039000948 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 685039000949 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 685039000950 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 685039000951 putative active site [active] 685039000952 putative FMN binding site [chemical binding]; other site 685039000953 putative substrate binding site [chemical binding]; other site 685039000954 putative catalytic residue [active] 685039000955 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 685039000956 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 685039000957 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 685039000958 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 685039000959 lipoyl attachment site [posttranslational modification]; other site 685039000960 Replication protein C N-terminal domain; Region: RP-C; pfam03428 685039000961 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 685039000962 putative ADP-ribose binding site [chemical binding]; other site 685039000963 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 685039000964 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 685039000965 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 685039000966 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 685039000967 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 685039000968 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 685039000969 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 685039000970 active site 685039000971 P-loop; other site 685039000972 phosphorylation site [posttranslational modification] 685039000973 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685039000974 active site 685039000975 phosphorylation site [posttranslational modification] 685039000976 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 685039000977 HTH domain; Region: HTH_11; pfam08279 685039000978 HTH domain; Region: HTH_11; pfam08279 685039000979 PRD domain; Region: PRD; pfam00874 685039000980 PRD domain; Region: PRD; pfam00874 685039000981 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 685039000982 active site 685039000983 P-loop; other site 685039000984 phosphorylation site [posttranslational modification] 685039000985 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685039000986 active site 685039000987 phosphorylation site [posttranslational modification] 685039000988 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685039000989 MarR family; Region: MarR_2; pfam12802 685039000990 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 685039000991 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 685039000992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 685039000993 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 685039000994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039000995 putative substrate translocation pore; other site 685039000996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039000997 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 685039000998 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685039000999 Zn binding site [ion binding]; other site 685039001000 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 685039001001 Zn binding site [ion binding]; other site 685039001002 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 685039001003 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685039001004 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 685039001005 Predicted flavoprotein [General function prediction only]; Region: COG0431 685039001006 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 685039001007 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 685039001008 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 685039001009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 685039001010 Imelysin; Region: Peptidase_M75; pfam09375 685039001011 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 685039001012 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 685039001013 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 685039001014 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 685039001015 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 685039001016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039001017 non-specific DNA binding site [nucleotide binding]; other site 685039001018 salt bridge; other site 685039001019 sequence-specific DNA binding site [nucleotide binding]; other site 685039001020 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 685039001021 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685039001022 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685039001023 Walker A/P-loop; other site 685039001024 ATP binding site [chemical binding]; other site 685039001025 Q-loop/lid; other site 685039001026 ABC transporter signature motif; other site 685039001027 Walker B; other site 685039001028 D-loop; other site 685039001029 H-loop/switch region; other site 685039001030 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 685039001031 Predicted membrane protein [Function unknown]; Region: COG4292 685039001032 putative acyltransferase; Provisional; Region: PRK05790 685039001033 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685039001034 dimer interface [polypeptide binding]; other site 685039001035 active site 685039001036 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 685039001037 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 685039001038 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 685039001039 THF binding site; other site 685039001040 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 685039001041 substrate binding site [chemical binding]; other site 685039001042 THF binding site; other site 685039001043 zinc-binding site [ion binding]; other site 685039001044 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 685039001045 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 685039001046 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 685039001047 FAD binding site [chemical binding]; other site 685039001048 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 685039001049 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 685039001050 homodimer interface [polypeptide binding]; other site 685039001051 substrate-cofactor binding pocket; other site 685039001052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039001053 catalytic residue [active] 685039001054 cystathionine gamma-synthase; Reviewed; Region: PRK08247 685039001055 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 685039001056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685039001057 catalytic residue [active] 685039001058 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 685039001059 ParB-like nuclease domain; Region: ParB; smart00470 685039001060 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 685039001061 Mechanosensitive ion channel; Region: MS_channel; pfam00924 685039001062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 685039001063 GTP-binding protein YchF; Reviewed; Region: PRK09601 685039001064 YchF GTPase; Region: YchF; cd01900 685039001065 G1 box; other site 685039001066 GTP/Mg2+ binding site [chemical binding]; other site 685039001067 Switch I region; other site 685039001068 G2 box; other site 685039001069 Switch II region; other site 685039001070 G3 box; other site 685039001071 G4 box; other site 685039001072 G5 box; other site 685039001073 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 685039001074 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 685039001075 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 685039001076 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685039001077 dimer interface [polypeptide binding]; other site 685039001078 ssDNA binding site [nucleotide binding]; other site 685039001079 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685039001080 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 685039001081 Abi-like protein; Region: Abi_2; pfam07751 685039001082 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 685039001083 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 685039001085 Predicted membrane protein [Function unknown]; Region: COG3212 685039001086 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 685039001087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 685039001088 non-specific DNA binding site [nucleotide binding]; other site 685039001089 salt bridge; other site 685039001090 sequence-specific DNA binding site [nucleotide binding]; other site 685039001091 Predicted membrane protein [Function unknown]; Region: COG2261 685039001092 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685039001093 catalytic core [active] 685039001094 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 685039001095 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 685039001096 catalytic residue [active] 685039001097 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 685039001098 catalytic residues [active] 685039001099 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685039001100 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039001101 peroxiredoxin; Region: AhpC; TIGR03137 685039001102 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 685039001103 dimer interface [polypeptide binding]; other site 685039001104 decamer (pentamer of dimers) interface [polypeptide binding]; other site 685039001105 catalytic triad [active] 685039001106 peroxidatic and resolving cysteines [active] 685039001107 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 685039001108 dimer interface [polypeptide binding]; other site 685039001109 FMN binding site [chemical binding]; other site 685039001110 NADPH bind site [chemical binding]; other site 685039001111 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 685039001112 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 685039001113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685039001114 active site 685039001115 xanthine permease; Region: pbuX; TIGR03173 685039001116 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 685039001117 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685039001118 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 685039001119 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 685039001120 active site 685039001121 GMP synthase; Reviewed; Region: guaA; PRK00074 685039001122 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 685039001123 AMP/PPi binding site [chemical binding]; other site 685039001124 candidate oxyanion hole; other site 685039001125 catalytic triad [active] 685039001126 potential glutamine specificity residues [chemical binding]; other site 685039001127 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 685039001128 ATP Binding subdomain [chemical binding]; other site 685039001129 Ligand Binding sites [chemical binding]; other site 685039001130 Dimerization subdomain; other site 685039001131 pathogenecity island SaPIov 685039001132 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 685039001133 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 685039001134 Int/Topo IB signature motif; other site 685039001135 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685039001136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039001137 non-specific DNA binding site [nucleotide binding]; other site 685039001138 salt bridge; other site 685039001139 sequence-specific DNA binding site [nucleotide binding]; other site 685039001140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039001141 non-specific DNA binding site [nucleotide binding]; other site 685039001142 salt bridge; other site 685039001143 sequence-specific DNA binding site [nucleotide binding]; other site 685039001144 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 685039001145 Uncharacterized conserved protein [Function unknown]; Region: COG4983 685039001146 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 685039001147 nucleotide binding site [chemical binding]; other site 685039001148 D5 N terminal like; Region: D5_N; smart00885 685039001149 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 685039001150 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 685039001151 Coat F domain; Region: Coat_F; cl17715 685039001152 Terminase small subunit; Region: Terminase_2; cl01513 685039001153 superantigen-like protein; Reviewed; Region: PRK13038 685039001154 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 685039001155 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001156 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 685039001157 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001158 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 685039001159 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001160 PemK-like protein; Region: PemK; pfam02452 685039001161 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 685039001162 Protein of unknown function (DUF523); Region: DUF523; pfam04463 685039001163 LabA_like proteins; Region: LabA_like; cd06167 685039001164 putative metal binding site [ion binding]; other site 685039001165 Uncharacterized conserved protein [Function unknown]; Region: COG1432 685039001166 Predicted membrane protein [Function unknown]; Region: COG3759 685039001167 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 685039001168 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 685039001169 NADP binding site [chemical binding]; other site 685039001170 superantigen-like protein; Reviewed; Region: PRK13037 685039001171 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001172 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001173 superantigen-like protein; Reviewed; Region: PRK13041 685039001174 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001175 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001176 superantigen-like protein; Reviewed; Region: PRK13335 685039001177 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001178 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001179 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 685039001180 superantigen-like protein; Reviewed; Region: PRK13042 685039001181 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001182 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001183 superantigen-like protein 5; Reviewed; Region: PRK13035 685039001184 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001185 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001186 superantigen-like protein; Reviewed; Region: PRK13040 685039001187 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001188 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001189 superantigen-like protein 7; Reviewed; Region: PRK13346 685039001190 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001191 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001192 superantigen-like protein; Reviewed; Region: PRK13039 685039001193 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001194 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001195 superantigen-like protein; Reviewed; Region: PRK13345 685039001196 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001197 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001198 superantigen-like protein; Reviewed; Region: PRK13038 685039001199 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001200 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001201 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 685039001202 HsdM N-terminal domain; Region: HsdM_N; pfam12161 685039001203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039001204 S-adenosylmethionine binding site [chemical binding]; other site 685039001205 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 685039001206 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 685039001207 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 685039001208 superantigen-like protein; Reviewed; Region: PRK13036 685039001209 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 685039001210 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039001211 Protein of unknown function, DUF576; Region: DUF576; pfam04507 685039001212 Protein of unknown function, DUF576; Region: DUF576; pfam04507 685039001213 Protein of unknown function, DUF576; Region: DUF576; pfam04507 685039001214 Transposase; Region: HTH_Tnp_1; cl17663 685039001215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039001216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039001217 Helix-turn-helix domain; Region: HTH_28; pfam13518 685039001218 HTH-like domain; Region: HTH_21; pfam13276 685039001219 Integrase core domain; Region: rve; pfam00665 685039001220 Integrase core domain; Region: rve_3; cl15866 685039001221 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 685039001222 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 685039001223 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 685039001224 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 685039001225 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685039001226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 685039001227 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 685039001228 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 685039001229 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 685039001230 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 685039001231 active site 685039001232 Esterase/lipase [General function prediction only]; Region: COG1647 685039001233 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685039001234 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 685039001235 Na2 binding site [ion binding]; other site 685039001236 putative substrate binding site 1 [chemical binding]; other site 685039001237 Na binding site 1 [ion binding]; other site 685039001238 putative substrate binding site 2 [chemical binding]; other site 685039001239 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 685039001240 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 685039001241 dimer interface [polypeptide binding]; other site 685039001242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039001243 catalytic residue [active] 685039001244 cystathionine beta-lyase; Provisional; Region: PRK07671 685039001245 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 685039001246 homodimer interface [polypeptide binding]; other site 685039001247 substrate-cofactor binding pocket; other site 685039001248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039001249 catalytic residue [active] 685039001250 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 685039001251 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 685039001252 Walker A/P-loop; other site 685039001253 ATP binding site [chemical binding]; other site 685039001254 Q-loop/lid; other site 685039001255 ABC transporter signature motif; other site 685039001256 Walker B; other site 685039001257 D-loop; other site 685039001258 H-loop/switch region; other site 685039001259 NIL domain; Region: NIL; pfam09383 685039001260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039001261 dimer interface [polypeptide binding]; other site 685039001262 conserved gate region; other site 685039001263 ABC-ATPase subunit interface; other site 685039001264 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 685039001265 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 685039001266 LysM domain; Region: LysM; pfam01476 685039001267 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685039001268 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685039001269 Surface antigen [General function prediction only]; Region: COG3942 685039001270 CHAP domain; Region: CHAP; pfam05257 685039001271 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 685039001272 nudix motif; other site 685039001273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039001274 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 685039001275 Coenzyme A binding pocket [chemical binding]; other site 685039001276 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 685039001277 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 685039001278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685039001279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685039001280 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 685039001281 dimerization interface [polypeptide binding]; other site 685039001282 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 685039001283 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 685039001284 active site 685039001285 dimer interface [polypeptide binding]; other site 685039001286 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 685039001287 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 685039001288 active site 685039001289 FMN binding site [chemical binding]; other site 685039001290 substrate binding site [chemical binding]; other site 685039001291 3Fe-4S cluster binding site [ion binding]; other site 685039001292 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 685039001293 domain interface; other site 685039001294 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 685039001295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685039001296 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 685039001297 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685039001298 active site turn [active] 685039001299 phosphorylation site [posttranslational modification] 685039001300 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685039001301 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 685039001302 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 685039001303 Ca binding site [ion binding]; other site 685039001304 active site 685039001305 catalytic site [active] 685039001306 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 685039001307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685039001308 DNA-binding site [nucleotide binding]; DNA binding site 685039001309 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 685039001310 UTRA domain; Region: UTRA; pfam07702 685039001311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039001312 Coenzyme A binding pocket [chemical binding]; other site 685039001313 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 685039001314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039001315 Walker A motif; other site 685039001316 ATP binding site [chemical binding]; other site 685039001317 Walker B motif; other site 685039001318 arginine finger; other site 685039001319 hypothetical protein; Validated; Region: PRK00153 685039001320 recombination protein RecR; Reviewed; Region: recR; PRK00076 685039001321 RecR protein; Region: RecR; pfam02132 685039001322 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 685039001323 putative active site [active] 685039001324 putative metal-binding site [ion binding]; other site 685039001325 tetramer interface [polypeptide binding]; other site 685039001326 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 685039001327 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 685039001328 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685039001329 catalytic residue [active] 685039001330 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 685039001331 thymidylate kinase; Validated; Region: tmk; PRK00698 685039001332 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 685039001333 TMP-binding site; other site 685039001334 ATP-binding site [chemical binding]; other site 685039001335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 685039001336 DNA polymerase III subunit delta'; Validated; Region: PRK08058 685039001337 DNA polymerase III subunit delta'; Validated; Region: PRK08485 685039001338 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 685039001339 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 685039001340 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 685039001341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039001342 S-adenosylmethionine binding site [chemical binding]; other site 685039001343 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 685039001344 GIY-YIG motif/motif A; other site 685039001345 putative active site [active] 685039001346 putative metal binding site [ion binding]; other site 685039001347 Predicted methyltransferases [General function prediction only]; Region: COG0313 685039001348 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 685039001349 putative SAM binding site [chemical binding]; other site 685039001350 putative homodimer interface [polypeptide binding]; other site 685039001351 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 685039001352 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 685039001353 active site 685039001354 HIGH motif; other site 685039001355 KMSKS motif; other site 685039001356 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 685039001357 tRNA binding surface [nucleotide binding]; other site 685039001358 anticodon binding site; other site 685039001359 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 685039001360 dimer interface [polypeptide binding]; other site 685039001361 putative tRNA-binding site [nucleotide binding]; other site 685039001362 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 685039001363 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 685039001364 active site 685039001365 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 685039001366 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 685039001367 putative active site [active] 685039001368 putative metal binding site [ion binding]; other site 685039001369 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 685039001370 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 685039001371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039001372 S-adenosylmethionine binding site [chemical binding]; other site 685039001373 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 685039001374 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 685039001375 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 685039001376 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 685039001377 pur operon repressor; Provisional; Region: PRK09213 685039001378 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 685039001379 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685039001380 active site 685039001381 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 685039001382 homotrimer interaction site [polypeptide binding]; other site 685039001383 putative active site [active] 685039001384 regulatory protein SpoVG; Reviewed; Region: PRK13259 685039001385 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 685039001386 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 685039001387 Substrate binding site; other site 685039001388 Mg++ binding site; other site 685039001389 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 685039001390 active site 685039001391 substrate binding site [chemical binding]; other site 685039001392 CoA binding site [chemical binding]; other site 685039001393 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 685039001394 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 685039001395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685039001396 active site 685039001397 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 685039001398 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 685039001399 5S rRNA interface [nucleotide binding]; other site 685039001400 CTC domain interface [polypeptide binding]; other site 685039001401 L16 interface [polypeptide binding]; other site 685039001402 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 685039001403 putative active site [active] 685039001404 catalytic residue [active] 685039001405 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 685039001406 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 685039001407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685039001408 ATP binding site [chemical binding]; other site 685039001409 putative Mg++ binding site [ion binding]; other site 685039001410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685039001411 nucleotide binding region [chemical binding]; other site 685039001412 ATP-binding site [chemical binding]; other site 685039001413 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 685039001414 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 685039001415 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 685039001416 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 685039001417 putative SAM binding site [chemical binding]; other site 685039001418 putative homodimer interface [polypeptide binding]; other site 685039001419 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 685039001420 homodimer interface [polypeptide binding]; other site 685039001421 metal binding site [ion binding]; metal-binding site 685039001422 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685039001423 RNA binding surface [nucleotide binding]; other site 685039001424 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 685039001425 Septum formation initiator; Region: DivIC; pfam04977 685039001426 hypothetical protein; Provisional; Region: PRK08582 685039001427 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 685039001428 RNA binding site [nucleotide binding]; other site 685039001429 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 685039001430 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 685039001431 Ligand Binding Site [chemical binding]; other site 685039001432 TilS substrate C-terminal domain; Region: TilS_C; smart00977 685039001433 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 685039001434 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685039001435 active site 685039001436 FtsH Extracellular; Region: FtsH_ext; pfam06480 685039001437 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 685039001438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039001439 Walker A motif; other site 685039001440 ATP binding site [chemical binding]; other site 685039001441 Walker B motif; other site 685039001442 arginine finger; other site 685039001443 Peptidase family M41; Region: Peptidase_M41; pfam01434 685039001444 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 685039001445 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 685039001446 dimerization interface [polypeptide binding]; other site 685039001447 domain crossover interface; other site 685039001448 redox-dependent activation switch; other site 685039001449 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 685039001450 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 685039001451 dimer interface [polypeptide binding]; other site 685039001452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039001453 catalytic residue [active] 685039001454 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 685039001455 dihydropteroate synthase; Region: DHPS; TIGR01496 685039001456 substrate binding pocket [chemical binding]; other site 685039001457 dimer interface [polypeptide binding]; other site 685039001458 inhibitor binding site; inhibition site 685039001459 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 685039001460 homooctamer interface [polypeptide binding]; other site 685039001461 active site 685039001462 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 685039001463 catalytic center binding site [active] 685039001464 ATP binding site [chemical binding]; other site 685039001465 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 685039001466 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 685039001467 dimer interface [polypeptide binding]; other site 685039001468 putative anticodon binding site; other site 685039001469 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 685039001470 motif 1; other site 685039001471 active site 685039001472 motif 2; other site 685039001473 motif 3; other site 685039001474 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 685039001475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685039001476 DNA-binding site [nucleotide binding]; DNA binding site 685039001477 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685039001478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039001479 homodimer interface [polypeptide binding]; other site 685039001480 catalytic residue [active] 685039001481 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 685039001482 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 685039001483 active site 685039001484 multimer interface [polypeptide binding]; other site 685039001485 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 685039001486 predicted active site [active] 685039001487 catalytic triad [active] 685039001488 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 685039001489 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 685039001490 Nucleoside recognition; Region: Gate; pfam07670 685039001491 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 685039001492 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 685039001493 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 685039001494 UvrB/uvrC motif; Region: UVR; pfam02151 685039001495 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 685039001496 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 685039001497 ADP binding site [chemical binding]; other site 685039001498 phosphagen binding site; other site 685039001499 substrate specificity loop; other site 685039001500 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 685039001501 Clp amino terminal domain; Region: Clp_N; pfam02861 685039001502 Clp amino terminal domain; Region: Clp_N; pfam02861 685039001503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039001504 Walker A motif; other site 685039001505 ATP binding site [chemical binding]; other site 685039001506 Walker B motif; other site 685039001507 arginine finger; other site 685039001508 UvrB/uvrC motif; Region: UVR; pfam02151 685039001509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039001510 Walker A motif; other site 685039001511 ATP binding site [chemical binding]; other site 685039001512 Walker B motif; other site 685039001513 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 685039001514 DNA repair protein RadA; Provisional; Region: PRK11823 685039001515 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 685039001516 Walker A motif/ATP binding site; other site 685039001517 ATP binding site [chemical binding]; other site 685039001518 Walker B motif; other site 685039001519 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 685039001520 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 685039001521 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 685039001522 putative active site [active] 685039001523 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 685039001524 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 685039001525 active site 685039001526 HIGH motif; other site 685039001527 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 685039001528 active site 685039001529 KMSKS motif; other site 685039001530 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 685039001531 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 685039001532 trimer interface [polypeptide binding]; other site 685039001533 active site 685039001534 substrate binding site [chemical binding]; other site 685039001535 CoA binding site [chemical binding]; other site 685039001536 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 685039001537 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 685039001538 active site 685039001539 HIGH motif; other site 685039001540 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 685039001541 KMSKS motif; other site 685039001542 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 685039001543 tRNA binding surface [nucleotide binding]; other site 685039001544 anticodon binding site; other site 685039001545 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 685039001546 active site 685039001547 metal binding site [ion binding]; metal-binding site 685039001548 dimerization interface [polypeptide binding]; other site 685039001549 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 685039001550 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 685039001551 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 685039001552 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 685039001553 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 685039001554 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685039001555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 685039001556 DNA binding residues [nucleotide binding] 685039001557 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 685039001558 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 685039001559 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 685039001560 putative homodimer interface [polypeptide binding]; other site 685039001561 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 685039001562 heterodimer interface [polypeptide binding]; other site 685039001563 homodimer interface [polypeptide binding]; other site 685039001564 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 685039001565 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 685039001566 23S rRNA interface [nucleotide binding]; other site 685039001567 L7/L12 interface [polypeptide binding]; other site 685039001568 putative thiostrepton binding site; other site 685039001569 L25 interface [polypeptide binding]; other site 685039001570 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 685039001571 mRNA/rRNA interface [nucleotide binding]; other site 685039001572 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 685039001573 23S rRNA interface [nucleotide binding]; other site 685039001574 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 685039001575 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 685039001576 peripheral dimer interface [polypeptide binding]; other site 685039001577 core dimer interface [polypeptide binding]; other site 685039001578 L10 interface [polypeptide binding]; other site 685039001579 L11 interface [polypeptide binding]; other site 685039001580 putative EF-Tu interaction site [polypeptide binding]; other site 685039001581 putative EF-G interaction site [polypeptide binding]; other site 685039001582 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685039001583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039001584 S-adenosylmethionine binding site [chemical binding]; other site 685039001585 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 685039001586 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 685039001587 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 685039001588 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 685039001589 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 685039001590 RPB10 interaction site [polypeptide binding]; other site 685039001591 RPB1 interaction site [polypeptide binding]; other site 685039001592 RPB11 interaction site [polypeptide binding]; other site 685039001593 RPB3 interaction site [polypeptide binding]; other site 685039001594 RPB12 interaction site [polypeptide binding]; other site 685039001595 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 685039001596 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 685039001597 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 685039001598 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 685039001599 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 685039001600 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 685039001601 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 685039001602 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 685039001603 G-loop; other site 685039001604 DNA binding site [nucleotide binding] 685039001605 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 685039001606 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 685039001607 S17 interaction site [polypeptide binding]; other site 685039001608 S8 interaction site; other site 685039001609 16S rRNA interaction site [nucleotide binding]; other site 685039001610 streptomycin interaction site [chemical binding]; other site 685039001611 23S rRNA interaction site [nucleotide binding]; other site 685039001612 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 685039001613 30S ribosomal protein S7; Validated; Region: PRK05302 685039001614 elongation factor G; Reviewed; Region: PRK00007 685039001615 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 685039001616 G1 box; other site 685039001617 putative GEF interaction site [polypeptide binding]; other site 685039001618 GTP/Mg2+ binding site [chemical binding]; other site 685039001619 Switch I region; other site 685039001620 G2 box; other site 685039001621 G3 box; other site 685039001622 Switch II region; other site 685039001623 G4 box; other site 685039001624 G5 box; other site 685039001625 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 685039001626 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 685039001627 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 685039001628 elongation factor Tu; Reviewed; Region: PRK00049 685039001629 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 685039001630 G1 box; other site 685039001631 GEF interaction site [polypeptide binding]; other site 685039001632 GTP/Mg2+ binding site [chemical binding]; other site 685039001633 Switch I region; other site 685039001634 G2 box; other site 685039001635 G3 box; other site 685039001636 Switch II region; other site 685039001637 G4 box; other site 685039001638 G5 box; other site 685039001639 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 685039001640 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 685039001641 Antibiotic Binding Site [chemical binding]; other site 685039001642 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 685039001643 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 685039001644 metal binding site [ion binding]; metal-binding site 685039001645 dimer interface [polypeptide binding]; other site 685039001646 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 685039001647 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 685039001648 substrate-cofactor binding pocket; other site 685039001649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039001650 catalytic residue [active] 685039001651 chaperone protein HchA; Provisional; Region: PRK04155 685039001652 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 685039001653 conserved cys residue [active] 685039001654 ribulokinase; Provisional; Region: PRK04123 685039001655 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 685039001656 N- and C-terminal domain interface [polypeptide binding]; other site 685039001657 active site 685039001658 MgATP binding site [chemical binding]; other site 685039001659 catalytic site [active] 685039001660 metal binding site [ion binding]; metal-binding site 685039001661 carbohydrate binding site [chemical binding]; other site 685039001662 homodimer interface [polypeptide binding]; other site 685039001663 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685039001664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685039001665 NAD(P) binding site [chemical binding]; other site 685039001666 active site 685039001667 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 685039001668 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 685039001669 homodimer interface [polypeptide binding]; other site 685039001670 substrate-cofactor binding pocket; other site 685039001671 catalytic residue [active] 685039001672 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 685039001673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039001674 motif II; other site 685039001675 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 685039001676 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 685039001677 Substrate-binding site [chemical binding]; other site 685039001678 Substrate specificity [chemical binding]; other site 685039001679 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 685039001680 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 685039001681 Substrate-binding site [chemical binding]; other site 685039001682 Substrate specificity [chemical binding]; other site 685039001683 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 685039001684 nucleoside/Zn binding site; other site 685039001685 dimer interface [polypeptide binding]; other site 685039001686 catalytic motif [active] 685039001687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039001688 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 685039001689 active site 685039001690 motif I; other site 685039001691 motif II; other site 685039001692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039001693 Predicted flavoprotein [General function prediction only]; Region: COG0431 685039001694 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 685039001695 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 685039001696 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 685039001697 Cna protein B-type domain; Region: Cna_B; pfam05738 685039001698 Cna protein B-type domain; Region: Cna_B; pfam05738 685039001699 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 685039001700 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 685039001701 Cna protein B-type domain; Region: Cna_B; pfam05738 685039001702 Cna protein B-type domain; Region: Cna_B; pfam05738 685039001703 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 685039001704 Cna protein B-type domain; Region: Cna_B; pfam05738 685039001705 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 685039001706 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 685039001707 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 685039001708 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 685039001709 Cna protein B-type domain; Region: Cna_B; pfam05738 685039001710 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 685039001711 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 685039001712 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 685039001713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 685039001714 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 685039001715 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 685039001716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 685039001717 putative GTP cyclohydrolase; Provisional; Region: PRK13674 685039001718 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 685039001719 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 685039001720 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 685039001721 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 685039001722 active site 685039001723 trimer interface [polypeptide binding]; other site 685039001724 allosteric site; other site 685039001725 active site lid [active] 685039001726 hexamer (dimer of trimers) interface [polypeptide binding]; other site 685039001727 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 685039001728 active site 685039001729 dimer interface [polypeptide binding]; other site 685039001730 magnesium binding site [ion binding]; other site 685039001731 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 685039001732 tetramer interface [polypeptide binding]; other site 685039001733 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 685039001734 active site 685039001735 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 685039001736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039001737 motif II; other site 685039001738 proline/glycine betaine transporter; Provisional; Region: PRK10642 685039001739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039001740 putative substrate translocation pore; other site 685039001741 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685039001742 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 685039001743 acyl-activating enzyme (AAE) consensus motif; other site 685039001744 AMP binding site [chemical binding]; other site 685039001745 active site 685039001746 CoA binding site [chemical binding]; other site 685039001747 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685039001748 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 685039001749 dimer interface [polypeptide binding]; other site 685039001750 active site 685039001751 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 685039001752 dimer interface [polypeptide binding]; other site 685039001753 substrate binding site [chemical binding]; other site 685039001754 ATP binding site [chemical binding]; other site 685039001755 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 685039001756 ligand binding site [chemical binding]; other site 685039001757 active site 685039001758 UGI interface [polypeptide binding]; other site 685039001759 catalytic site [active] 685039001760 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 685039001761 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 685039001762 Uncharacterized conserved protein [Function unknown]; Region: COG3610 685039001763 Uncharacterized conserved protein [Function unknown]; Region: COG2966 685039001764 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 685039001765 putative heme peroxidase; Provisional; Region: PRK12276 685039001766 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 685039001767 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 685039001768 mevalonate kinase; Region: mevalon_kin; TIGR00549 685039001769 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 685039001770 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 685039001771 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 685039001772 diphosphomevalonate decarboxylase; Region: PLN02407 685039001773 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 685039001774 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 685039001775 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 685039001776 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 685039001777 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 685039001778 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 685039001779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039001780 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 685039001781 Predicted transcriptional regulator [Transcription]; Region: COG1959 685039001782 Transcriptional regulator; Region: Rrf2; pfam02082 685039001783 LXG domain of WXG superfamily; Region: LXG; pfam04740 685039001784 Protein of unknown function (DUF443); Region: DUF443; pfam04276 685039001785 Protein of unknown function (DUF443); Region: DUF443; pfam04276 685039001786 Protein of unknown function (DUF443); Region: DUF443; pfam04276 685039001787 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685039001788 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685039001789 active site 685039001790 catalytic tetrad [active] 685039001791 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 685039001792 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 685039001793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 685039001794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039001795 Coenzyme A binding pocket [chemical binding]; other site 685039001796 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 685039001797 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685039001798 Zn2+ binding site [ion binding]; other site 685039001799 Mg2+ binding site [ion binding]; other site 685039001800 YwhD family; Region: YwhD; pfam08741 685039001801 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 685039001802 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 685039001803 NAD binding site [chemical binding]; other site 685039001804 substrate binding site [chemical binding]; other site 685039001805 catalytic Zn binding site [ion binding]; other site 685039001806 tetramer interface [polypeptide binding]; other site 685039001807 structural Zn binding site [ion binding]; other site 685039001808 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 685039001809 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 685039001810 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 685039001811 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 685039001812 active site 685039001813 HIGH motif; other site 685039001814 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 685039001815 KMSK motif region; other site 685039001816 tRNA binding surface [nucleotide binding]; other site 685039001817 DALR anticodon binding domain; Region: DALR_1; smart00836 685039001818 anticodon binding site; other site 685039001819 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 685039001820 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 685039001821 minor groove reading motif; other site 685039001822 helix-hairpin-helix signature motif; other site 685039001823 substrate binding pocket [chemical binding]; other site 685039001824 active site 685039001825 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685039001826 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 685039001827 putative binding site residues; other site 685039001828 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 685039001829 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 685039001830 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039001831 ABC-ATPase subunit interface; other site 685039001832 dimer interface [polypeptide binding]; other site 685039001833 putative PBP binding regions; other site 685039001834 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 685039001835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039001836 motif II; other site 685039001837 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685039001838 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685039001839 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685039001840 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685039001841 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 685039001842 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685039001843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 685039001844 Protein of unknown function, DUF606; Region: DUF606; pfam04657 685039001845 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 685039001846 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 685039001847 active site 685039001848 DNA binding site [nucleotide binding] 685039001849 Int/Topo IB signature motif; other site 685039001850 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 685039001851 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685039001852 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 685039001853 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 685039001854 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 685039001855 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 685039001856 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685039001857 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 685039001858 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 685039001859 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 685039001860 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 685039001861 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 685039001862 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 685039001863 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 685039001864 metal binding site [ion binding]; metal-binding site 685039001865 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 685039001866 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039001867 ABC-ATPase subunit interface; other site 685039001868 dimer interface [polypeptide binding]; other site 685039001869 putative PBP binding regions; other site 685039001870 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 685039001871 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 685039001872 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 685039001873 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 685039001874 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 685039001875 FeoA domain; Region: FeoA; pfam04023 685039001876 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 685039001877 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 685039001878 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 685039001879 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 685039001880 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 685039001881 Walker A/P-loop; other site 685039001882 ATP binding site [chemical binding]; other site 685039001883 Q-loop/lid; other site 685039001884 ABC transporter signature motif; other site 685039001885 Walker B; other site 685039001886 D-loop; other site 685039001887 H-loop/switch region; other site 685039001888 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 685039001889 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685039001890 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 685039001891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 685039001892 active site 685039001893 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 685039001894 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 685039001895 active site 685039001896 nucleotide binding site [chemical binding]; other site 685039001897 HIGH motif; other site 685039001898 KMSKS motif; other site 685039001899 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 685039001900 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 685039001901 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 685039001902 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685039001903 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685039001904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039001905 Walker A/P-loop; other site 685039001906 ATP binding site [chemical binding]; other site 685039001907 Q-loop/lid; other site 685039001908 ABC transporter signature motif; other site 685039001909 Walker B; other site 685039001910 D-loop; other site 685039001911 H-loop/switch region; other site 685039001912 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 685039001913 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 685039001914 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 685039001915 Uncharacterized conserved protein [Function unknown]; Region: COG1284 685039001916 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 685039001917 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 685039001918 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 685039001919 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685039001920 Walker A/P-loop; other site 685039001921 ATP binding site [chemical binding]; other site 685039001922 Q-loop/lid; other site 685039001923 ABC transporter signature motif; other site 685039001924 Walker B; other site 685039001925 D-loop; other site 685039001926 H-loop/switch region; other site 685039001927 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685039001928 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039001929 ABC-ATPase subunit interface; other site 685039001930 dimer interface [polypeptide binding]; other site 685039001931 putative PBP binding regions; other site 685039001932 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 685039001933 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039001934 ABC-ATPase subunit interface; other site 685039001935 dimer interface [polypeptide binding]; other site 685039001936 putative PBP binding regions; other site 685039001937 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 685039001938 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 685039001939 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 685039001940 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 685039001941 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 685039001942 Uncharacterized membrane protein [Function unknown]; Region: COG3949 685039001943 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 685039001944 Na binding site [ion binding]; other site 685039001945 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 685039001946 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 685039001947 substrate binding pocket [chemical binding]; other site 685039001948 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685039001949 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 685039001950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039001951 Coenzyme A binding pocket [chemical binding]; other site 685039001952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 685039001953 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685039001954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685039001955 NAD(P) binding site [chemical binding]; other site 685039001956 active site 685039001957 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685039001958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039001959 active site 685039001960 phosphorylation site [posttranslational modification] 685039001961 intermolecular recognition site; other site 685039001962 dimerization interface [polypeptide binding]; other site 685039001963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685039001964 DNA binding site [nucleotide binding] 685039001965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685039001966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 685039001967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039001968 ATP binding site [chemical binding]; other site 685039001969 Mg2+ binding site [ion binding]; other site 685039001970 G-X-G motif; other site 685039001971 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685039001972 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685039001973 Walker A/P-loop; other site 685039001974 ATP binding site [chemical binding]; other site 685039001975 Q-loop/lid; other site 685039001976 ABC transporter signature motif; other site 685039001977 Walker B; other site 685039001978 D-loop; other site 685039001979 H-loop/switch region; other site 685039001980 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 685039001981 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 685039001982 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685039001983 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 685039001984 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685039001985 Surface antigen [General function prediction only]; Region: COG3942 685039001986 CHAP domain; Region: CHAP; pfam05257 685039001987 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 685039001988 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 685039001989 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685039001990 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 685039001991 hypothetical protein; Provisional; Region: PRK12378 685039001992 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 685039001993 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 685039001994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685039001995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685039001996 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 685039001997 dimerization interface [polypeptide binding]; other site 685039001998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039001999 sugar efflux transporter; Region: 2A0120; TIGR00899 685039002000 putative substrate translocation pore; other site 685039002001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 685039002002 Serine incorporator (Serinc); Region: Serinc; pfam03348 685039002003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039002004 Coenzyme A binding pocket [chemical binding]; other site 685039002005 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 685039002006 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 685039002007 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 685039002008 hypothetical protein; Validated; Region: PRK00124 685039002009 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 685039002010 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 685039002011 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 685039002012 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685039002013 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 685039002014 Walker A/P-loop; other site 685039002015 ATP binding site [chemical binding]; other site 685039002016 Q-loop/lid; other site 685039002017 ABC transporter signature motif; other site 685039002018 Walker B; other site 685039002019 D-loop; other site 685039002020 H-loop/switch region; other site 685039002021 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 685039002022 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685039002023 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 685039002024 Walker A/P-loop; other site 685039002025 ATP binding site [chemical binding]; other site 685039002026 Q-loop/lid; other site 685039002027 ABC transporter signature motif; other site 685039002028 Walker B; other site 685039002029 D-loop; other site 685039002030 H-loop/switch region; other site 685039002031 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685039002032 MarR family; Region: MarR; pfam01047 685039002033 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 685039002034 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 685039002035 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 685039002036 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685039002037 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685039002038 active site 685039002039 catalytic tetrad [active] 685039002040 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 685039002041 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 685039002042 transmembrane helices; other site 685039002043 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 685039002044 DNA photolyase; Region: DNA_photolyase; pfam00875 685039002045 Predicted membrane protein [Function unknown]; Region: COG4330 685039002046 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 685039002047 trimer interface [polypeptide binding]; other site 685039002048 putative Zn binding site [ion binding]; other site 685039002049 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685039002050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039002051 putative substrate translocation pore; other site 685039002052 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 685039002053 putative deacylase active site [active] 685039002054 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 685039002055 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 685039002056 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685039002057 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 685039002058 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 685039002059 putative substrate binding site [chemical binding]; other site 685039002060 putative ATP binding site [chemical binding]; other site 685039002061 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 685039002062 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685039002063 active site 685039002064 phosphorylation site [posttranslational modification] 685039002065 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 685039002066 active site 685039002067 P-loop; other site 685039002068 phosphorylation site [posttranslational modification] 685039002069 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 685039002070 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 685039002071 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 685039002072 active site 685039002073 dimer interface [polypeptide binding]; other site 685039002074 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 685039002075 Domain of unknown function DUF21; Region: DUF21; pfam01595 685039002076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685039002077 Transporter associated domain; Region: CorC_HlyC; pfam03471 685039002078 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685039002079 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685039002080 active site 685039002081 catalytic tetrad [active] 685039002082 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 685039002083 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 685039002084 Ligand binding site; other site 685039002085 Putative Catalytic site; other site 685039002086 DXD motif; other site 685039002087 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685039002088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685039002089 dimer interface [polypeptide binding]; other site 685039002090 phosphorylation site [posttranslational modification] 685039002091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039002092 ATP binding site [chemical binding]; other site 685039002093 Mg2+ binding site [ion binding]; other site 685039002094 G-X-G motif; other site 685039002095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685039002096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039002097 active site 685039002098 phosphorylation site [posttranslational modification] 685039002099 intermolecular recognition site; other site 685039002100 dimerization interface [polypeptide binding]; other site 685039002101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685039002102 DNA binding site [nucleotide binding] 685039002103 DoxX; Region: DoxX; pfam07681 685039002104 Electron transfer DM13; Region: DM13; pfam10517 685039002105 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 685039002106 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 685039002107 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 685039002108 active site 685039002109 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 685039002110 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 685039002111 Ligand Binding Site [chemical binding]; other site 685039002112 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 685039002113 Glutamine amidotransferase class-I; Region: GATase; pfam00117 685039002114 glutamine binding [chemical binding]; other site 685039002115 catalytic triad [active] 685039002116 aminodeoxychorismate synthase; Provisional; Region: PRK07508 685039002117 chorismate binding enzyme; Region: Chorismate_bind; cl10555 685039002118 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 685039002119 substrate-cofactor binding pocket; other site 685039002120 Aminotransferase class IV; Region: Aminotran_4; pfam01063 685039002121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039002122 catalytic residue [active] 685039002123 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 685039002124 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 685039002125 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 685039002126 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 685039002127 Sulfatase; Region: Sulfatase; pfam00884 685039002128 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 685039002129 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685039002130 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685039002131 ABC transporter; Region: ABC_tran_2; pfam12848 685039002132 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685039002133 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 685039002134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685039002135 ATP binding site [chemical binding]; other site 685039002136 putative Mg++ binding site [ion binding]; other site 685039002137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685039002138 nucleotide binding region [chemical binding]; other site 685039002139 ATP-binding site [chemical binding]; other site 685039002140 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 685039002141 HRDC domain; Region: HRDC; pfam00570 685039002142 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 685039002143 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 685039002144 Walker A/P-loop; other site 685039002145 ATP binding site [chemical binding]; other site 685039002146 Q-loop/lid; other site 685039002147 ABC transporter signature motif; other site 685039002148 Walker B; other site 685039002149 D-loop; other site 685039002150 H-loop/switch region; other site 685039002151 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685039002152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039002153 dimer interface [polypeptide binding]; other site 685039002154 conserved gate region; other site 685039002155 ABC-ATPase subunit interface; other site 685039002156 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 685039002157 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 685039002158 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 685039002159 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685039002160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039002161 homodimer interface [polypeptide binding]; other site 685039002162 catalytic residue [active] 685039002163 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 685039002164 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 685039002165 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 685039002166 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 685039002167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039002168 putative substrate translocation pore; other site 685039002169 POT family; Region: PTR2; cl17359 685039002170 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 685039002171 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 685039002172 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 685039002173 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 685039002174 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 685039002175 Class I ribonucleotide reductase; Region: RNR_I; cd01679 685039002176 active site 685039002177 dimer interface [polypeptide binding]; other site 685039002178 catalytic residues [active] 685039002179 effector binding site; other site 685039002180 R2 peptide binding site; other site 685039002181 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 685039002182 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 685039002183 dimer interface [polypeptide binding]; other site 685039002184 putative radical transfer pathway; other site 685039002185 diiron center [ion binding]; other site 685039002186 tyrosyl radical; other site 685039002187 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039002188 ABC-ATPase subunit interface; other site 685039002189 dimer interface [polypeptide binding]; other site 685039002190 putative PBP binding regions; other site 685039002191 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039002192 ABC-ATPase subunit interface; other site 685039002193 dimer interface [polypeptide binding]; other site 685039002194 putative PBP binding regions; other site 685039002195 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 685039002196 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685039002197 Walker A/P-loop; other site 685039002198 ATP binding site [chemical binding]; other site 685039002199 Q-loop/lid; other site 685039002200 ABC transporter signature motif; other site 685039002201 Walker B; other site 685039002202 D-loop; other site 685039002203 H-loop/switch region; other site 685039002204 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 685039002205 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 685039002206 putative ligand binding residues [chemical binding]; other site 685039002207 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 685039002208 CHY zinc finger; Region: zf-CHY; pfam05495 685039002209 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 685039002210 FAD binding domain; Region: FAD_binding_4; pfam01565 685039002211 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 685039002212 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 685039002213 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 685039002214 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 685039002215 peptidase T; Region: peptidase-T; TIGR01882 685039002216 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 685039002217 metal binding site [ion binding]; metal-binding site 685039002218 dimer interface [polypeptide binding]; other site 685039002219 Uncharacterized conserved protein [Function unknown]; Region: COG3610 685039002220 Uncharacterized conserved protein [Function unknown]; Region: COG2966 685039002221 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 685039002222 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 685039002223 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 685039002224 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 685039002225 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 685039002226 metal binding site [ion binding]; metal-binding site 685039002227 active site 685039002228 I-site; other site 685039002229 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 685039002230 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 685039002231 Mg++ binding site [ion binding]; other site 685039002232 putative catalytic motif [active] 685039002233 substrate binding site [chemical binding]; other site 685039002234 Uncharacterized conserved protein [Function unknown]; Region: COG1739 685039002235 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 685039002236 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 685039002237 EDD domain protein, DegV family; Region: DegV; TIGR00762 685039002238 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 685039002239 DEAD-like helicases superfamily; Region: DEXDc; smart00487 685039002240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685039002241 ATP binding site [chemical binding]; other site 685039002242 putative Mg++ binding site [ion binding]; other site 685039002243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685039002244 nucleotide binding region [chemical binding]; other site 685039002245 ATP-binding site [chemical binding]; other site 685039002246 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 685039002247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685039002248 active site 685039002249 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 685039002250 30S subunit binding site; other site 685039002251 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 685039002252 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 685039002253 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 685039002254 nucleotide binding region [chemical binding]; other site 685039002255 ATP-binding site [chemical binding]; other site 685039002256 SEC-C motif; Region: SEC-C; pfam02810 685039002257 peptide chain release factor 2; Provisional; Region: PRK06746 685039002258 This domain is found in peptide chain release factors; Region: PCRF; smart00937 685039002259 RF-1 domain; Region: RF-1; pfam00472 685039002260 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 685039002261 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685039002262 Surface antigen [General function prediction only]; Region: COG3942 685039002263 CHAP domain; Region: CHAP; pfam05257 685039002264 HD domain; Region: HD_3; cl17350 685039002265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 685039002266 excinuclease ABC subunit B; Provisional; Region: PRK05298 685039002267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685039002268 ATP binding site [chemical binding]; other site 685039002269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685039002270 nucleotide binding region [chemical binding]; other site 685039002271 ATP-binding site [chemical binding]; other site 685039002272 Ultra-violet resistance protein B; Region: UvrB; pfam12344 685039002273 UvrB/uvrC motif; Region: UVR; pfam02151 685039002274 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 685039002275 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 685039002276 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 685039002277 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 685039002278 HPr kinase/phosphorylase; Provisional; Region: PRK05428 685039002279 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 685039002280 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 685039002281 Hpr binding site; other site 685039002282 active site 685039002283 homohexamer subunit interaction site [polypeptide binding]; other site 685039002284 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 685039002285 putative acyl transferase; Provisional; Region: PRK10191 685039002286 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 685039002287 trimer interface [polypeptide binding]; other site 685039002288 active site 685039002289 substrate binding site [chemical binding]; other site 685039002290 CoA binding site [chemical binding]; other site 685039002291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 685039002292 binding surface 685039002293 TPR motif; other site 685039002294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 685039002295 TPR motif; other site 685039002296 binding surface 685039002297 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 685039002298 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685039002299 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039002300 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 685039002301 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 685039002302 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 685039002303 phosphate binding site [ion binding]; other site 685039002304 dimer interface [polypeptide binding]; other site 685039002305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 685039002306 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 685039002307 Clp protease; Region: CLP_protease; pfam00574 685039002308 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 685039002309 oligomer interface [polypeptide binding]; other site 685039002310 active site residues [active] 685039002311 malate dehydrogenase; Provisional; Region: PRK13529 685039002312 Malic enzyme, N-terminal domain; Region: malic; pfam00390 685039002313 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 685039002314 NAD(P) binding site [chemical binding]; other site 685039002315 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 685039002316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685039002317 NAD(P) binding site [chemical binding]; other site 685039002318 active site 685039002319 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 685039002320 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 685039002321 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 685039002322 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 685039002323 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 685039002324 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 685039002325 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 685039002326 Phosphoglycerate kinase; Region: PGK; pfam00162 685039002327 substrate binding site [chemical binding]; other site 685039002328 hinge regions; other site 685039002329 ADP binding site [chemical binding]; other site 685039002330 catalytic site [active] 685039002331 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 685039002332 triosephosphate isomerase; Provisional; Region: PRK14565 685039002333 substrate binding site [chemical binding]; other site 685039002334 dimer interface [polypeptide binding]; other site 685039002335 catalytic triad [active] 685039002336 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 685039002337 phosphoglyceromutase; Provisional; Region: PRK05434 685039002338 enolase; Provisional; Region: eno; PRK00077 685039002339 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 685039002340 dimer interface [polypeptide binding]; other site 685039002341 metal binding site [ion binding]; metal-binding site 685039002342 substrate binding pocket [chemical binding]; other site 685039002343 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 685039002344 Esterase/lipase [General function prediction only]; Region: COG1647 685039002345 ribonuclease R; Region: RNase_R; TIGR02063 685039002346 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 685039002347 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 685039002348 RNB domain; Region: RNB; pfam00773 685039002349 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 685039002350 RNA binding site [nucleotide binding]; other site 685039002351 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 685039002352 SmpB-tmRNA interface; other site 685039002353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039002354 Coenzyme A binding pocket [chemical binding]; other site 685039002355 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 685039002356 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 685039002357 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 685039002358 Staphylococcal nuclease homologues; Region: SNc; smart00318 685039002359 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 685039002360 Catalytic site; other site 685039002361 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685039002362 DNA-binding site [nucleotide binding]; DNA binding site 685039002363 RNA-binding motif; other site 685039002364 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 685039002365 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 685039002366 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685039002367 catalytic core [active] 685039002368 Lysine efflux permease [General function prediction only]; Region: COG1279 685039002369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 685039002370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 685039002371 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 685039002372 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 685039002373 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 685039002374 active site 685039002375 catalytic residue [active] 685039002376 dimer interface [polypeptide binding]; other site 685039002377 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 685039002378 putative FMN binding site [chemical binding]; other site 685039002379 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 685039002380 catalytic residues [active] 685039002381 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 685039002382 ArsC family; Region: ArsC; pfam03960 685039002383 putative ArsC-like catalytic residues; other site 685039002384 putative TRX-like catalytic residues [active] 685039002385 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 685039002386 lipoyl attachment site [posttranslational modification]; other site 685039002387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 685039002388 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 685039002389 putative active site [active] 685039002390 putative metal binding site [ion binding]; other site 685039002391 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 685039002392 catalytic residues [active] 685039002393 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 685039002394 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 685039002395 Walker A/P-loop; other site 685039002396 ATP binding site [chemical binding]; other site 685039002397 Q-loop/lid; other site 685039002398 ABC transporter signature motif; other site 685039002399 Walker B; other site 685039002400 D-loop; other site 685039002401 H-loop/switch region; other site 685039002402 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 685039002403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039002404 dimer interface [polypeptide binding]; other site 685039002405 conserved gate region; other site 685039002406 ABC-ATPase subunit interface; other site 685039002407 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 685039002408 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 685039002409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 685039002410 Predicted membrane protein [Function unknown]; Region: COG2035 685039002411 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 685039002412 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 685039002413 Walker A/P-loop; other site 685039002414 ATP binding site [chemical binding]; other site 685039002415 Q-loop/lid; other site 685039002416 ABC transporter signature motif; other site 685039002417 Walker B; other site 685039002418 D-loop; other site 685039002419 H-loop/switch region; other site 685039002420 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 685039002421 FeS assembly protein SufD; Region: sufD; TIGR01981 685039002422 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 685039002423 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 685039002424 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685039002425 catalytic residue [active] 685039002426 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 685039002427 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 685039002428 trimerization site [polypeptide binding]; other site 685039002429 active site 685039002430 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 685039002431 FeS assembly protein SufB; Region: sufB; TIGR01980 685039002432 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 685039002433 Domain of unknown function DUF21; Region: DUF21; pfam01595 685039002434 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685039002435 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 685039002436 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 685039002437 FMN binding site [chemical binding]; other site 685039002438 substrate binding site [chemical binding]; other site 685039002439 putative catalytic residue [active] 685039002440 Uncharacterized conserved protein [Function unknown]; Region: COG1801 685039002441 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 685039002442 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 685039002443 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 685039002444 active site 685039002445 metal binding site [ion binding]; metal-binding site 685039002446 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 685039002447 lipoyl synthase; Provisional; Region: PRK05481 685039002448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685039002449 FeS/SAM binding site; other site 685039002450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 685039002451 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 685039002452 Uncharacterized conserved protein [Function unknown]; Region: COG2445 685039002453 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 685039002454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039002455 active site 685039002456 motif I; other site 685039002457 motif II; other site 685039002458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039002459 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 685039002460 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 685039002461 dimerization interface [polypeptide binding]; other site 685039002462 ligand binding site [chemical binding]; other site 685039002463 NADP binding site [chemical binding]; other site 685039002464 catalytic site [active] 685039002465 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 685039002466 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 685039002467 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 685039002468 acyl-activating enzyme (AAE) consensus motif; other site 685039002469 AMP binding site [chemical binding]; other site 685039002470 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 685039002471 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 685039002472 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 685039002473 DltD N-terminal region; Region: DltD_N; pfam04915 685039002474 DltD central region; Region: DltD_M; pfam04918 685039002475 DltD C-terminal region; Region: DltD_C; pfam04914 685039002476 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 685039002477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 685039002478 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 685039002479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039002480 hypothetical protein; Provisional; Region: PRK13669 685039002481 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 685039002482 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 685039002483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039002484 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 685039002485 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 685039002486 interface (dimer of trimers) [polypeptide binding]; other site 685039002487 Substrate-binding/catalytic site; other site 685039002488 Zn-binding sites [ion binding]; other site 685039002489 Predicted permease [General function prediction only]; Region: COG2056 685039002490 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 685039002491 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 685039002492 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685039002493 CoenzymeA binding site [chemical binding]; other site 685039002494 subunit interaction site [polypeptide binding]; other site 685039002495 PHB binding site; other site 685039002496 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685039002497 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 685039002498 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 685039002499 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 685039002500 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 685039002501 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 685039002502 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685039002503 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 685039002504 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 685039002505 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 685039002506 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685039002507 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 685039002508 Kinase associated protein B; Region: KapB; pfam08810 685039002509 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 685039002510 active site 685039002511 general stress protein 13; Validated; Region: PRK08059 685039002512 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 685039002513 RNA binding site [nucleotide binding]; other site 685039002514 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 685039002515 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 685039002516 putative active site [active] 685039002517 putative FMN binding site [chemical binding]; other site 685039002518 putative substrate binding site [chemical binding]; other site 685039002519 putative catalytic residue [active] 685039002520 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 685039002521 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685039002522 inhibitor-cofactor binding pocket; inhibition site 685039002523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039002524 catalytic residue [active] 685039002525 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 685039002526 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 685039002527 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 685039002528 NAD(P) binding site [chemical binding]; other site 685039002529 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 685039002530 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 685039002531 active site 685039002532 catalytic site [active] 685039002533 metal binding site [ion binding]; metal-binding site 685039002534 argininosuccinate lyase; Provisional; Region: PRK00855 685039002535 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 685039002536 active sites [active] 685039002537 tetramer interface [polypeptide binding]; other site 685039002538 argininosuccinate synthase; Provisional; Region: PRK13820 685039002539 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 685039002540 ANP binding site [chemical binding]; other site 685039002541 Substrate Binding Site II [chemical binding]; other site 685039002542 Substrate Binding Site I [chemical binding]; other site 685039002543 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 685039002544 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 685039002545 active site 685039002546 dimer interface [polypeptide binding]; other site 685039002547 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 685039002548 dimer interface [polypeptide binding]; other site 685039002549 active site 685039002550 Uncharacterized conserved protein [Function unknown]; Region: COG0398 685039002551 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 685039002552 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 685039002553 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 685039002554 Catalytic site [active] 685039002555 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 685039002556 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 685039002557 Catalytic site [active] 685039002558 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 685039002559 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 685039002560 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 685039002561 Part of AAA domain; Region: AAA_19; pfam13245 685039002562 Family description; Region: UvrD_C_2; pfam13538 685039002563 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 685039002564 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 685039002565 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 685039002566 hypothetical protein; Provisional; Region: PRK13673 685039002567 coenzyme A disulfide reductase; Provisional; Region: PRK13512 685039002568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685039002569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039002570 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 685039002571 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 685039002572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039002573 active site 685039002574 motif I; other site 685039002575 motif II; other site 685039002576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039002577 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 685039002578 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 685039002579 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 685039002580 catalytic triad [active] 685039002581 catalytic triad [active] 685039002582 oxyanion hole [active] 685039002583 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 685039002584 Clp amino terminal domain; Region: Clp_N; pfam02861 685039002585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039002586 Walker A motif; other site 685039002587 ATP binding site [chemical binding]; other site 685039002588 Walker B motif; other site 685039002589 arginine finger; other site 685039002590 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 685039002591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039002592 Walker A motif; other site 685039002593 ATP binding site [chemical binding]; other site 685039002594 Walker B motif; other site 685039002595 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 685039002596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685039002597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685039002598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 685039002599 dimerization interface [polypeptide binding]; other site 685039002600 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 685039002601 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 685039002602 active site 685039002603 metal binding site [ion binding]; metal-binding site 685039002604 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 685039002605 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 685039002606 substrate binding site [chemical binding]; other site 685039002607 MAP domain; Region: MAP; pfam03642 685039002608 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 685039002609 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 685039002610 dimer interface [polypeptide binding]; other site 685039002611 active site 685039002612 CoA binding pocket [chemical binding]; other site 685039002613 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 685039002614 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 685039002615 dimer interface [polypeptide binding]; other site 685039002616 active site 685039002617 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 685039002618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685039002619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039002620 dimer interface [polypeptide binding]; other site 685039002621 conserved gate region; other site 685039002622 putative PBP binding loops; other site 685039002623 ABC-ATPase subunit interface; other site 685039002624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 685039002625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039002626 dimer interface [polypeptide binding]; other site 685039002627 conserved gate region; other site 685039002628 putative PBP binding loops; other site 685039002629 ABC-ATPase subunit interface; other site 685039002630 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 685039002631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685039002632 Walker A/P-loop; other site 685039002633 ATP binding site [chemical binding]; other site 685039002634 Q-loop/lid; other site 685039002635 ABC transporter signature motif; other site 685039002636 Walker B; other site 685039002637 D-loop; other site 685039002638 H-loop/switch region; other site 685039002639 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685039002640 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 685039002641 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685039002642 Walker A/P-loop; other site 685039002643 ATP binding site [chemical binding]; other site 685039002644 Q-loop/lid; other site 685039002645 ABC transporter signature motif; other site 685039002646 Walker B; other site 685039002647 D-loop; other site 685039002648 H-loop/switch region; other site 685039002649 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685039002650 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 685039002651 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 685039002652 peptide binding site [polypeptide binding]; other site 685039002653 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685039002654 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 685039002655 peptide binding site [polypeptide binding]; other site 685039002656 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 685039002657 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685039002658 Walker A/P-loop; other site 685039002659 ATP binding site [chemical binding]; other site 685039002660 Q-loop/lid; other site 685039002661 ABC transporter signature motif; other site 685039002662 Walker B; other site 685039002663 D-loop; other site 685039002664 H-loop/switch region; other site 685039002665 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685039002666 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 685039002667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685039002668 Walker A/P-loop; other site 685039002669 ATP binding site [chemical binding]; other site 685039002670 Q-loop/lid; other site 685039002671 ABC transporter signature motif; other site 685039002672 Walker B; other site 685039002673 D-loop; other site 685039002674 H-loop/switch region; other site 685039002675 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 685039002676 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685039002677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039002678 dimer interface [polypeptide binding]; other site 685039002679 conserved gate region; other site 685039002680 putative PBP binding loops; other site 685039002681 ABC-ATPase subunit interface; other site 685039002682 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 685039002683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039002684 dimer interface [polypeptide binding]; other site 685039002685 conserved gate region; other site 685039002686 putative PBP binding loops; other site 685039002687 ABC-ATPase subunit interface; other site 685039002688 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 685039002689 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 685039002690 active site 685039002691 HIGH motif; other site 685039002692 dimer interface [polypeptide binding]; other site 685039002693 KMSKS motif; other site 685039002694 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 685039002695 ArsC family; Region: ArsC; pfam03960 685039002696 putative catalytic residues [active] 685039002697 thiol/disulfide switch; other site 685039002698 adaptor protein; Provisional; Region: PRK02315 685039002699 Competence protein CoiA-like family; Region: CoiA; cl11541 685039002700 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 685039002701 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 685039002702 active site 685039002703 Zn binding site [ion binding]; other site 685039002704 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 685039002705 Thioredoxin; Region: Thioredoxin_5; pfam13743 685039002706 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 685039002707 apolar tunnel; other site 685039002708 heme binding site [chemical binding]; other site 685039002709 dimerization interface [polypeptide binding]; other site 685039002710 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 685039002711 putative active site [active] 685039002712 putative metal binding residues [ion binding]; other site 685039002713 signature motif; other site 685039002714 putative triphosphate binding site [ion binding]; other site 685039002715 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 685039002716 synthetase active site [active] 685039002717 NTP binding site [chemical binding]; other site 685039002718 metal binding site [ion binding]; metal-binding site 685039002719 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 685039002720 ATP-NAD kinase; Region: NAD_kinase; pfam01513 685039002721 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 685039002722 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 685039002723 active site 685039002724 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 685039002725 MgtE intracellular N domain; Region: MgtE_N; smart00924 685039002726 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 685039002727 Divalent cation transporter; Region: MgtE; pfam01769 685039002728 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 685039002729 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 685039002730 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 685039002731 TrkA-N domain; Region: TrkA_N; pfam02254 685039002732 TrkA-C domain; Region: TrkA_C; pfam02080 685039002733 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 685039002734 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 685039002735 NAD binding site [chemical binding]; other site 685039002736 homotetramer interface [polypeptide binding]; other site 685039002737 homodimer interface [polypeptide binding]; other site 685039002738 substrate binding site [chemical binding]; other site 685039002739 active site 685039002740 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 685039002741 Domain of unknown function DUF20; Region: UPF0118; pfam01594 685039002742 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 685039002743 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 685039002744 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 685039002745 Putative esterase; Region: Esterase; pfam00756 685039002746 hypothetical protein; Provisional; Region: PRK13679 685039002747 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 685039002748 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039002749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039002750 putative substrate translocation pore; other site 685039002751 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 685039002752 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 685039002753 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 685039002754 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 685039002755 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685039002756 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685039002757 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685039002758 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 685039002759 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 685039002760 G1 box; other site 685039002761 putative GEF interaction site [polypeptide binding]; other site 685039002762 GTP/Mg2+ binding site [chemical binding]; other site 685039002763 Switch I region; other site 685039002764 G2 box; other site 685039002765 G3 box; other site 685039002766 Switch II region; other site 685039002767 G4 box; other site 685039002768 G5 box; other site 685039002769 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 685039002770 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 685039002771 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 685039002772 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 685039002773 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685039002774 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 685039002775 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 685039002776 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 685039002777 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 685039002778 active site 685039002779 metal binding site [ion binding]; metal-binding site 685039002780 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 685039002781 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 685039002782 IDEAL domain; Region: IDEAL; pfam08858 685039002783 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 685039002784 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 685039002785 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 685039002786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 685039002787 CAAX protease self-immunity; Region: Abi; pfam02517 685039002788 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 685039002789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 685039002790 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 685039002791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 685039002792 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685039002793 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 685039002794 Walker A/P-loop; other site 685039002795 ATP binding site [chemical binding]; other site 685039002796 Q-loop/lid; other site 685039002797 ABC transporter signature motif; other site 685039002798 Walker B; other site 685039002799 D-loop; other site 685039002800 H-loop/switch region; other site 685039002801 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 685039002802 Predicted membrane protein [Function unknown]; Region: COG2259 685039002803 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 685039002804 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685039002805 siderophore binding site; other site 685039002806 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 685039002807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039002808 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 685039002809 Coenzyme A binding pocket [chemical binding]; other site 685039002810 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 685039002811 UbiA prenyltransferase family; Region: UbiA; pfam01040 685039002812 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 685039002813 isochorismate synthases; Region: isochor_syn; TIGR00543 685039002814 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 685039002815 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 685039002816 dimer interface [polypeptide binding]; other site 685039002817 tetramer interface [polypeptide binding]; other site 685039002818 PYR/PP interface [polypeptide binding]; other site 685039002819 TPP binding site [chemical binding]; other site 685039002820 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 685039002821 TPP-binding site; other site 685039002822 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 685039002823 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685039002824 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 685039002825 substrate binding site [chemical binding]; other site 685039002826 oxyanion hole (OAH) forming residues; other site 685039002827 trimer interface [polypeptide binding]; other site 685039002828 Staphostatin B; Region: Staphostatin_B; pfam09023 685039002829 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 685039002830 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 685039002831 aminotransferase A; Validated; Region: PRK07683 685039002832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685039002833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039002834 homodimer interface [polypeptide binding]; other site 685039002835 catalytic residue [active] 685039002836 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 685039002837 Acyltransferase family; Region: Acyl_transf_3; pfam01757 685039002838 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685039002839 MarR family; Region: MarR; pfam01047 685039002840 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 685039002841 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 685039002842 amidase catalytic site [active] 685039002843 Zn binding residues [ion binding]; other site 685039002844 substrate binding site [chemical binding]; other site 685039002845 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 685039002846 Lysozyme subfamily 2; Region: LYZ2; smart00047 685039002847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039002848 Coenzyme A binding pocket [chemical binding]; other site 685039002849 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 685039002850 Transcriptional regulator [Transcription]; Region: LytR; COG1316 685039002851 Beta-lactamase; Region: Beta-lactamase; pfam00144 685039002852 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685039002853 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 685039002854 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 685039002855 Subunit I/III interface [polypeptide binding]; other site 685039002856 Subunit III/IV interface [polypeptide binding]; other site 685039002857 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 685039002858 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 685039002859 D-pathway; other site 685039002860 Putative ubiquinol binding site [chemical binding]; other site 685039002861 Low-spin heme (heme b) binding site [chemical binding]; other site 685039002862 Putative water exit pathway; other site 685039002863 Binuclear center (heme o3/CuB) [ion binding]; other site 685039002864 K-pathway; other site 685039002865 Putative proton exit pathway; other site 685039002866 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 685039002867 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 685039002868 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 685039002869 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 685039002870 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 685039002871 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 685039002872 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 685039002873 homodimer interface [polypeptide binding]; other site 685039002874 NADP binding site [chemical binding]; other site 685039002875 substrate binding site [chemical binding]; other site 685039002876 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 685039002877 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 685039002878 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 685039002879 NAD binding site [chemical binding]; other site 685039002880 ATP-grasp domain; Region: ATP-grasp; pfam02222 685039002881 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 685039002882 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 685039002883 ATP binding site [chemical binding]; other site 685039002884 active site 685039002885 substrate binding site [chemical binding]; other site 685039002886 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 685039002887 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 685039002888 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 685039002889 putative active site [active] 685039002890 catalytic triad [active] 685039002891 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 685039002892 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 685039002893 dimerization interface [polypeptide binding]; other site 685039002894 ATP binding site [chemical binding]; other site 685039002895 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 685039002896 dimerization interface [polypeptide binding]; other site 685039002897 ATP binding site [chemical binding]; other site 685039002898 amidophosphoribosyltransferase; Provisional; Region: PRK07272 685039002899 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 685039002900 active site 685039002901 tetramer interface [polypeptide binding]; other site 685039002902 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685039002903 active site 685039002904 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 685039002905 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 685039002906 dimerization interface [polypeptide binding]; other site 685039002907 putative ATP binding site [chemical binding]; other site 685039002908 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 685039002909 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 685039002910 active site 685039002911 substrate binding site [chemical binding]; other site 685039002912 cosubstrate binding site; other site 685039002913 catalytic site [active] 685039002914 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 685039002915 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 685039002916 purine monophosphate binding site [chemical binding]; other site 685039002917 dimer interface [polypeptide binding]; other site 685039002918 putative catalytic residues [active] 685039002919 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 685039002920 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 685039002921 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 685039002922 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 685039002923 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 685039002924 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 685039002925 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 685039002926 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 685039002927 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 685039002928 Q-loop/lid; other site 685039002929 ABC transporter signature motif; other site 685039002930 Walker B; other site 685039002931 D-loop; other site 685039002932 H-loop/switch region; other site 685039002933 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 685039002934 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 685039002935 Walker A/P-loop; other site 685039002936 ATP binding site [chemical binding]; other site 685039002937 Q-loop/lid; other site 685039002938 ABC transporter signature motif; other site 685039002939 Walker B; other site 685039002940 D-loop; other site 685039002941 H-loop/switch region; other site 685039002942 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 685039002943 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 685039002944 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 685039002945 putative RNA binding site [nucleotide binding]; other site 685039002946 Methyltransferase domain; Region: Methyltransf_26; pfam13659 685039002947 Domain of unknown function (DUF697); Region: DUF697; cl12064 685039002948 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 685039002949 dimerization domain swap beta strand [polypeptide binding]; other site 685039002950 regulatory protein interface [polypeptide binding]; other site 685039002951 active site 685039002952 regulatory phosphorylation site [posttranslational modification]; other site 685039002953 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 685039002954 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 685039002955 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 685039002956 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 685039002957 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 685039002958 catalytic residues [active] 685039002959 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 685039002960 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 685039002961 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 685039002962 TrkA-N domain; Region: TrkA_N; pfam02254 685039002963 TrkA-C domain; Region: TrkA_C; pfam02080 685039002964 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 685039002965 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 685039002966 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 685039002967 hypothetical protein; Provisional; Region: PRK13667 685039002968 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 685039002969 active site 685039002970 catalytic residues [active] 685039002971 metal binding site [ion binding]; metal-binding site 685039002972 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 685039002973 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 685039002974 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 685039002975 TPP-binding site [chemical binding]; other site 685039002976 tetramer interface [polypeptide binding]; other site 685039002977 heterodimer interface [polypeptide binding]; other site 685039002978 phosphorylation loop region [posttranslational modification] 685039002979 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 685039002980 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 685039002981 alpha subunit interface [polypeptide binding]; other site 685039002982 TPP binding site [chemical binding]; other site 685039002983 heterodimer interface [polypeptide binding]; other site 685039002984 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 685039002985 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 685039002986 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685039002987 E3 interaction surface; other site 685039002988 lipoyl attachment site [posttranslational modification]; other site 685039002989 e3 binding domain; Region: E3_binding; pfam02817 685039002990 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 685039002991 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 685039002992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685039002993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039002994 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 685039002995 hypothetical protein; Provisional; Region: PRK04387 685039002996 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685039002997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039002998 non-specific DNA binding site [nucleotide binding]; other site 685039002999 salt bridge; other site 685039003000 sequence-specific DNA binding site [nucleotide binding]; other site 685039003001 Cupin domain; Region: Cupin_2; cl17218 685039003002 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 685039003003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039003004 Walker A/P-loop; other site 685039003005 ATP binding site [chemical binding]; other site 685039003006 Q-loop/lid; other site 685039003007 ABC transporter signature motif; other site 685039003008 Walker B; other site 685039003009 D-loop; other site 685039003010 H-loop/switch region; other site 685039003011 TOBE domain; Region: TOBE_2; pfam08402 685039003012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 685039003013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039003014 putative PBP binding loops; other site 685039003015 dimer interface [polypeptide binding]; other site 685039003016 ABC-ATPase subunit interface; other site 685039003017 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 685039003018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039003019 dimer interface [polypeptide binding]; other site 685039003020 conserved gate region; other site 685039003021 putative PBP binding loops; other site 685039003022 ABC-ATPase subunit interface; other site 685039003023 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 685039003024 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 685039003025 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 685039003026 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 685039003027 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 685039003028 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 685039003029 manganese transport protein MntH; Reviewed; Region: PRK00701 685039003030 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 685039003031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 685039003032 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 685039003033 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 685039003034 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 685039003035 active site 685039003036 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 685039003037 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 685039003038 G1 box; other site 685039003039 putative GEF interaction site [polypeptide binding]; other site 685039003040 GTP/Mg2+ binding site [chemical binding]; other site 685039003041 Switch I region; other site 685039003042 G2 box; other site 685039003043 G3 box; other site 685039003044 Switch II region; other site 685039003045 G4 box; other site 685039003046 G5 box; other site 685039003047 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 685039003048 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 685039003049 hypothetical protein; Provisional; Region: PRK13666 685039003050 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 685039003051 pyruvate carboxylase; Reviewed; Region: PRK12999 685039003052 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685039003053 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 685039003054 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 685039003055 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 685039003056 active site 685039003057 catalytic residues [active] 685039003058 metal binding site [ion binding]; metal-binding site 685039003059 homodimer binding site [polypeptide binding]; other site 685039003060 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 685039003061 carboxyltransferase (CT) interaction site; other site 685039003062 biotinylation site [posttranslational modification]; other site 685039003063 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 685039003064 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 685039003065 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 685039003066 UbiA prenyltransferase family; Region: UbiA; pfam01040 685039003067 Predicted membrane protein [Function unknown]; Region: COG2322 685039003068 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 685039003069 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 685039003070 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 685039003071 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 685039003072 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 685039003073 putative active site [active] 685039003074 catalytic site [active] 685039003075 putative metal binding site [ion binding]; other site 685039003076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 685039003077 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 685039003078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039003079 S-adenosylmethionine binding site [chemical binding]; other site 685039003080 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 685039003081 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 685039003082 active site 685039003083 (T/H)XGH motif; other site 685039003084 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 685039003085 hypothetical protein; Provisional; Region: PRK13670 685039003086 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 685039003087 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 685039003088 Probable integrated prophage, phiSaov2 685039003089 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 685039003090 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 685039003091 catalytic residues [active] 685039003092 catalytic nucleophile [active] 685039003093 Presynaptic Site I dimer interface [polypeptide binding]; other site 685039003094 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 685039003095 Synaptic Flat tetramer interface [polypeptide binding]; other site 685039003096 Synaptic Site I dimer interface [polypeptide binding]; other site 685039003097 DNA binding site [nucleotide binding] 685039003098 Recombinase; Region: Recombinase; pfam07508 685039003099 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685039003100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039003101 non-specific DNA binding site [nucleotide binding]; other site 685039003102 salt bridge; other site 685039003103 sequence-specific DNA binding site [nucleotide binding]; other site 685039003104 Predicted transcriptional regulator [Transcription]; Region: COG2932 685039003105 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 685039003106 Catalytic site [active] 685039003107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039003108 non-specific DNA binding site [nucleotide binding]; other site 685039003109 salt bridge; other site 685039003110 sequence-specific DNA binding site [nucleotide binding]; other site 685039003111 Prophage antirepressor [Transcription]; Region: COG3617 685039003112 BRO family, N-terminal domain; Region: Bro-N; smart01040 685039003113 ORF6C domain; Region: ORF6C; pfam10552 685039003114 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 685039003115 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 685039003116 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 685039003117 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 685039003118 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685039003119 dimer interface [polypeptide binding]; other site 685039003120 ssDNA binding site [nucleotide binding]; other site 685039003121 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685039003122 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 685039003123 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 685039003124 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 685039003125 Walker A motif; other site 685039003126 ATP binding site [chemical binding]; other site 685039003127 Walker B motif; other site 685039003128 DNA binding loops [nucleotide binding] 685039003129 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 685039003130 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 685039003131 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 685039003132 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 685039003133 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 685039003134 trimer interface [polypeptide binding]; other site 685039003135 active site 685039003136 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 685039003137 Transcriptional activator RinB; Region: RinB; pfam06116 685039003138 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 685039003139 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 685039003140 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 685039003141 HNH endonuclease; Region: HNH; pfam01844 685039003142 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 685039003143 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 685039003144 Phage-related protein [Function unknown]; Region: COG4695; cl01923 685039003145 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 685039003146 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 685039003147 oligomer interface [polypeptide binding]; other site 685039003148 active site residues [active] 685039003149 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 685039003150 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 685039003151 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 685039003152 Phage-related minor tail protein [Function unknown]; Region: COG5280 685039003153 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 685039003154 Phage-related protein [Function unknown]; Region: COG5412 685039003155 Peptidase family M23; Region: Peptidase_M23; pfam01551 685039003156 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 685039003157 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685039003158 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685039003159 catalytic residue [active] 685039003160 Phage tail protein; Region: Sipho_tail; cl17486 685039003161 Phage tail protein; Region: Sipho_tail; cl17486 685039003162 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 685039003163 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 685039003164 Ligand-gated ion channel; Region: Lig_chan; pfam00060 685039003165 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 685039003166 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039003167 Bacteriophage holin; Region: Phage_holin_1; pfam04531 685039003168 CHAP domain; Region: CHAP; pfam05257 685039003169 NUMOD4 motif; Region: NUMOD4; pfam07463 685039003170 HNH endonuclease; Region: HNH_3; pfam13392 685039003171 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 685039003172 Bacterial SH3 domain; Region: SH3_5; pfam08460 685039003173 heme uptake protein IsdB; Region: IsdB; TIGR03657 685039003174 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 685039003175 NEAr Transporter domain; Region: NEAT; smart00725 685039003176 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 685039003177 heme-binding site [chemical binding]; other site 685039003178 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 685039003179 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 685039003180 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 685039003181 heme-binding site [chemical binding]; other site 685039003182 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 685039003183 heme-binding site [chemical binding]; other site 685039003184 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 685039003185 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685039003186 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 685039003187 intersubunit interface [polypeptide binding]; other site 685039003188 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685039003189 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039003190 ABC-ATPase subunit interface; other site 685039003191 dimer interface [polypeptide binding]; other site 685039003192 putative PBP binding regions; other site 685039003193 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 685039003194 active site 685039003195 catalytic site [active] 685039003196 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 685039003197 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 685039003198 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 685039003199 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 685039003200 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 685039003201 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 685039003202 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 685039003203 dimer interface [polypeptide binding]; other site 685039003204 motif 1; other site 685039003205 active site 685039003206 motif 2; other site 685039003207 motif 3; other site 685039003208 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 685039003209 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 685039003210 putative tRNA-binding site [nucleotide binding]; other site 685039003211 B3/4 domain; Region: B3_4; pfam03483 685039003212 tRNA synthetase B5 domain; Region: B5; smart00874 685039003213 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 685039003214 dimer interface [polypeptide binding]; other site 685039003215 motif 1; other site 685039003216 motif 3; other site 685039003217 motif 2; other site 685039003218 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 685039003219 ribonuclease HIII; Provisional; Region: PRK00996 685039003220 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 685039003221 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 685039003222 RNA/DNA hybrid binding site [nucleotide binding]; other site 685039003223 active site 685039003224 Cell division protein ZapA; Region: ZapA; cl01146 685039003225 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 685039003226 Colicin V production protein; Region: Colicin_V; pfam02674 685039003227 hypothetical protein; Provisional; Region: PRK08609 685039003228 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 685039003229 active site 685039003230 primer binding site [nucleotide binding]; other site 685039003231 NTP binding site [chemical binding]; other site 685039003232 metal binding triad [ion binding]; metal-binding site 685039003233 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 685039003234 active site 685039003235 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 685039003236 MutS domain III; Region: MutS_III; pfam05192 685039003237 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 685039003238 Walker A/P-loop; other site 685039003239 ATP binding site [chemical binding]; other site 685039003240 Q-loop/lid; other site 685039003241 ABC transporter signature motif; other site 685039003242 Walker B; other site 685039003243 D-loop; other site 685039003244 H-loop/switch region; other site 685039003245 Smr domain; Region: Smr; pfam01713 685039003246 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 685039003247 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 685039003248 catalytic residues [active] 685039003249 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 685039003250 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 685039003251 GIY-YIG motif/motif A; other site 685039003252 active site 685039003253 catalytic site [active] 685039003254 putative DNA binding site [nucleotide binding]; other site 685039003255 metal binding site [ion binding]; metal-binding site 685039003256 UvrB/uvrC motif; Region: UVR; pfam02151 685039003257 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 685039003258 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 685039003259 putative Iron-sulfur protein interface [polypeptide binding]; other site 685039003260 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 685039003261 proximal heme binding site [chemical binding]; other site 685039003262 distal heme binding site [chemical binding]; other site 685039003263 putative dimer interface [polypeptide binding]; other site 685039003264 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 685039003265 L-aspartate oxidase; Provisional; Region: PRK06175 685039003266 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 685039003267 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 685039003268 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 685039003269 glutamate racemase; Provisional; Region: PRK00865 685039003270 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 685039003271 active site 685039003272 dimerization interface [polypeptide binding]; other site 685039003273 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 685039003274 active site 685039003275 metal binding site [ion binding]; metal-binding site 685039003276 homotetramer interface [polypeptide binding]; other site 685039003277 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 685039003278 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 685039003279 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 685039003280 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 685039003281 beta-channel forming cytolysin; Region: hlyII; TIGR01002 685039003282 superantigen-like protein; Reviewed; Region: PRK13350 685039003283 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039003284 superantigen-like protein; Reviewed; Region: PRK13349 685039003285 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039003286 superantigen-like protein; Reviewed; Region: PRK13043 685039003287 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039003288 ornithine carbamoyltransferase; Provisional; Region: PRK04284 685039003289 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 685039003290 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 685039003291 carbamate kinase; Reviewed; Region: PRK12686 685039003292 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 685039003293 putative substrate binding site [chemical binding]; other site 685039003294 nucleotide binding site [chemical binding]; other site 685039003295 nucleotide binding site [chemical binding]; other site 685039003296 homodimer interface [polypeptide binding]; other site 685039003297 Predicted membrane protein [Function unknown]; Region: COG1288 685039003298 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 685039003299 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 685039003300 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 685039003301 gating phenylalanine in ion channel; other site 685039003302 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 685039003303 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 685039003304 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 685039003305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039003306 motif II; other site 685039003307 hypothetical protein; Provisional; Region: PRK13688 685039003308 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 685039003309 Coenzyme A binding pocket [chemical binding]; other site 685039003310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 685039003311 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 685039003312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 685039003313 MraZ protein; Region: MraZ; pfam02381 685039003314 MraZ protein; Region: MraZ; pfam02381 685039003315 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 685039003316 MraW methylase family; Region: Methyltransf_5; pfam01795 685039003317 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 685039003318 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 685039003319 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 685039003320 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685039003321 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 685039003322 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 685039003323 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 685039003324 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 685039003325 Mg++ binding site [ion binding]; other site 685039003326 putative catalytic motif [active] 685039003327 putative substrate binding site [chemical binding]; other site 685039003328 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 685039003329 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 685039003330 NAD binding site [chemical binding]; other site 685039003331 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685039003332 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685039003333 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 685039003334 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 685039003335 Cell division protein FtsQ; Region: FtsQ; pfam03799 685039003336 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 685039003337 Cell division protein FtsA; Region: FtsA; smart00842 685039003338 Cell division protein FtsA; Region: FtsA; pfam14450 685039003339 cell division protein FtsZ; Validated; Region: PRK09330 685039003340 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 685039003341 nucleotide binding site [chemical binding]; other site 685039003342 SulA interaction site; other site 685039003343 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 685039003344 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 685039003345 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 685039003346 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685039003347 catalytic residue [active] 685039003348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 685039003349 YGGT family; Region: YGGT; pfam02325 685039003350 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 685039003351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685039003352 RNA binding surface [nucleotide binding]; other site 685039003353 DivIVA protein; Region: DivIVA; pfam05103 685039003354 DivIVA domain; Region: DivI1A_domain; TIGR03544 685039003355 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 685039003356 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 685039003357 HIGH motif; other site 685039003358 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 685039003359 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 685039003360 active site 685039003361 KMSKS motif; other site 685039003362 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 685039003363 tRNA binding surface [nucleotide binding]; other site 685039003364 anticodon binding site; other site 685039003365 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 685039003366 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 685039003367 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 685039003368 active site 685039003369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 685039003370 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 685039003371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039003372 Transposase; Region: HTH_Tnp_1; pfam01527 685039003373 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 685039003374 lipoprotein signal peptidase; Provisional; Region: PRK14787 685039003375 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 685039003376 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685039003377 RNA binding surface [nucleotide binding]; other site 685039003378 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 685039003379 active site 685039003380 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 685039003381 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 685039003382 uracil transporter; Provisional; Region: PRK10720 685039003383 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 685039003384 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 685039003385 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 685039003386 dihydroorotase; Validated; Region: pyrC; PRK09357 685039003387 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685039003388 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 685039003389 active site 685039003390 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 685039003391 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 685039003392 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 685039003393 catalytic site [active] 685039003394 subunit interface [polypeptide binding]; other site 685039003395 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 685039003396 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685039003397 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 685039003398 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 685039003399 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685039003400 ATP-grasp domain; Region: ATP-grasp_4; cl17255 685039003401 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 685039003402 IMP binding site; other site 685039003403 dimer interface [polypeptide binding]; other site 685039003404 interdomain contacts; other site 685039003405 partial ornithine binding site; other site 685039003406 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 685039003407 active site 685039003408 dimer interface [polypeptide binding]; other site 685039003409 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685039003410 active site 685039003411 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 685039003412 dimer interface [polypeptide binding]; other site 685039003413 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 685039003414 Domain of unknown function (DUF814); Region: DUF814; pfam05670 685039003415 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 685039003416 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 685039003417 catalytic site [active] 685039003418 G-X2-G-X-G-K; other site 685039003419 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 685039003420 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 685039003421 Flavoprotein; Region: Flavoprotein; pfam02441 685039003422 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 685039003423 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 685039003424 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685039003425 ATP binding site [chemical binding]; other site 685039003426 putative Mg++ binding site [ion binding]; other site 685039003427 helicase superfamily c-terminal domain; Region: HELICc; smart00490 685039003428 nucleotide binding region [chemical binding]; other site 685039003429 ATP-binding site [chemical binding]; other site 685039003430 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 685039003431 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 685039003432 active site 685039003433 catalytic residues [active] 685039003434 metal binding site [ion binding]; metal-binding site 685039003435 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 685039003436 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 685039003437 putative active site [active] 685039003438 substrate binding site [chemical binding]; other site 685039003439 putative cosubstrate binding site; other site 685039003440 catalytic site [active] 685039003441 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 685039003442 substrate binding site [chemical binding]; other site 685039003443 16S rRNA methyltransferase B; Provisional; Region: PRK14902 685039003444 NusB family; Region: NusB; pfam01029 685039003445 putative RNA binding site [nucleotide binding]; other site 685039003446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039003447 S-adenosylmethionine binding site [chemical binding]; other site 685039003448 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 685039003449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685039003450 FeS/SAM binding site; other site 685039003451 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 685039003452 Protein phosphatase 2C; Region: PP2C; pfam00481 685039003453 active site 685039003454 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 685039003455 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 685039003456 active site 685039003457 ATP binding site [chemical binding]; other site 685039003458 substrate binding site [chemical binding]; other site 685039003459 activation loop (A-loop); other site 685039003460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 685039003461 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 685039003462 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 685039003463 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 685039003464 Predicted GTPases [General function prediction only]; Region: COG1162 685039003465 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 685039003466 RNA binding site [nucleotide binding]; other site 685039003467 homodimer interface [polypeptide binding]; other site 685039003468 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 685039003469 GTPase/Zn-binding domain interface [polypeptide binding]; other site 685039003470 GTP/Mg2+ binding site [chemical binding]; other site 685039003471 G4 box; other site 685039003472 G5 box; other site 685039003473 G1 box; other site 685039003474 Switch I region; other site 685039003475 G2 box; other site 685039003476 G3 box; other site 685039003477 Switch II region; other site 685039003478 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 685039003479 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 685039003480 substrate binding site [chemical binding]; other site 685039003481 hexamer interface [polypeptide binding]; other site 685039003482 metal binding site [ion binding]; metal-binding site 685039003483 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 685039003484 Thiamine pyrophosphokinase; Region: TPK; cd07995 685039003485 active site 685039003486 dimerization interface [polypeptide binding]; other site 685039003487 thiamine binding site [chemical binding]; other site 685039003488 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 685039003489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 685039003490 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 685039003491 DAK2 domain; Region: Dak2; pfam02734 685039003492 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 685039003493 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 685039003494 generic binding surface II; other site 685039003495 ssDNA binding site; other site 685039003496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685039003497 ATP binding site [chemical binding]; other site 685039003498 putative Mg++ binding site [ion binding]; other site 685039003499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685039003500 nucleotide binding region [chemical binding]; other site 685039003501 ATP-binding site [chemical binding]; other site 685039003502 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 685039003503 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 685039003504 active site 2 [active] 685039003505 active site 1 [active] 685039003506 putative phosphate acyltransferase; Provisional; Region: PRK05331 685039003507 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 685039003508 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 685039003509 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 685039003510 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 685039003511 NAD(P) binding site [chemical binding]; other site 685039003512 homotetramer interface [polypeptide binding]; other site 685039003513 homodimer interface [polypeptide binding]; other site 685039003514 active site 685039003515 acyl carrier protein; Provisional; Region: acpP; PRK00982 685039003516 ribonuclease III; Reviewed; Region: rnc; PRK00102 685039003517 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 685039003518 dimerization interface [polypeptide binding]; other site 685039003519 active site 685039003520 metal binding site [ion binding]; metal-binding site 685039003521 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 685039003522 dsRNA binding site [nucleotide binding]; other site 685039003523 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 685039003524 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 685039003525 Walker A/P-loop; other site 685039003526 ATP binding site [chemical binding]; other site 685039003527 Q-loop/lid; other site 685039003528 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 685039003529 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 685039003530 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 685039003531 ABC transporter signature motif; other site 685039003532 Walker B; other site 685039003533 D-loop; other site 685039003534 H-loop/switch region; other site 685039003535 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 685039003536 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 685039003537 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 685039003538 P loop; other site 685039003539 GTP binding site [chemical binding]; other site 685039003540 putative DNA-binding protein; Validated; Region: PRK00118 685039003541 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 685039003542 signal recognition particle protein; Provisional; Region: PRK10867 685039003543 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 685039003544 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 685039003545 P loop; other site 685039003546 GTP binding site [chemical binding]; other site 685039003547 Signal peptide binding domain; Region: SRP_SPB; pfam02978 685039003548 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 685039003549 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 685039003550 RimM N-terminal domain; Region: RimM; pfam01782 685039003551 PRC-barrel domain; Region: PRC; pfam05239 685039003552 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 685039003553 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 685039003554 Predicted membrane protein [Function unknown]; Region: COG4485 685039003555 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 685039003556 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 685039003557 GTP/Mg2+ binding site [chemical binding]; other site 685039003558 G4 box; other site 685039003559 G5 box; other site 685039003560 G1 box; other site 685039003561 Switch I region; other site 685039003562 G2 box; other site 685039003563 G3 box; other site 685039003564 Switch II region; other site 685039003565 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 685039003566 RNA/DNA hybrid binding site [nucleotide binding]; other site 685039003567 active site 685039003568 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 685039003569 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 685039003570 CoA-ligase; Region: Ligase_CoA; pfam00549 685039003571 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 685039003572 CoA binding domain; Region: CoA_binding; pfam02629 685039003573 CoA-ligase; Region: Ligase_CoA; pfam00549 685039003574 FemAB family; Region: FemAB; pfam02388 685039003575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 685039003576 DNA protecting protein DprA; Region: dprA; TIGR00732 685039003577 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 685039003578 DNA topoisomerase I; Validated; Region: PRK05582 685039003579 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 685039003580 active site 685039003581 interdomain interaction site; other site 685039003582 putative metal-binding site [ion binding]; other site 685039003583 nucleotide binding site [chemical binding]; other site 685039003584 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 685039003585 domain I; other site 685039003586 DNA binding groove [nucleotide binding] 685039003587 phosphate binding site [ion binding]; other site 685039003588 domain II; other site 685039003589 domain III; other site 685039003590 nucleotide binding site [chemical binding]; other site 685039003591 catalytic site [active] 685039003592 domain IV; other site 685039003593 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 685039003594 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 685039003595 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 685039003596 Glucose inhibited division protein A; Region: GIDA; pfam01134 685039003597 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 685039003598 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 685039003599 active site 685039003600 DNA binding site [nucleotide binding] 685039003601 Int/Topo IB signature motif; other site 685039003602 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 685039003603 active site 685039003604 HslU subunit interaction site [polypeptide binding]; other site 685039003605 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 685039003606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039003607 Walker A motif; other site 685039003608 ATP binding site [chemical binding]; other site 685039003609 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 685039003610 Walker B motif; other site 685039003611 arginine finger; other site 685039003612 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 685039003613 transcriptional repressor CodY; Validated; Region: PRK04158 685039003614 CodY GAF-like domain; Region: CodY; pfam06018 685039003615 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 685039003616 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 685039003617 rRNA interaction site [nucleotide binding]; other site 685039003618 S8 interaction site; other site 685039003619 putative laminin-1 binding site; other site 685039003620 elongation factor Ts; Provisional; Region: tsf; PRK09377 685039003621 UBA/TS-N domain; Region: UBA; pfam00627 685039003622 Elongation factor TS; Region: EF_TS; pfam00889 685039003623 Elongation factor TS; Region: EF_TS; pfam00889 685039003624 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 685039003625 putative nucleotide binding site [chemical binding]; other site 685039003626 uridine monophosphate binding site [chemical binding]; other site 685039003627 homohexameric interface [polypeptide binding]; other site 685039003628 ribosome recycling factor; Reviewed; Region: frr; PRK00083 685039003629 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 685039003630 hinge region; other site 685039003631 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 685039003632 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 685039003633 catalytic residue [active] 685039003634 putative FPP diphosphate binding site; other site 685039003635 putative FPP binding hydrophobic cleft; other site 685039003636 dimer interface [polypeptide binding]; other site 685039003637 putative IPP diphosphate binding site; other site 685039003638 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 685039003639 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 685039003640 RIP metalloprotease RseP; Region: TIGR00054 685039003641 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 685039003642 active site 685039003643 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 685039003644 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 685039003645 protein binding site [polypeptide binding]; other site 685039003646 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 685039003647 putative substrate binding region [chemical binding]; other site 685039003648 prolyl-tRNA synthetase; Provisional; Region: PRK09194 685039003649 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 685039003650 dimer interface [polypeptide binding]; other site 685039003651 motif 1; other site 685039003652 active site 685039003653 motif 2; other site 685039003654 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 685039003655 putative deacylase active site [active] 685039003656 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 685039003657 active site 685039003658 motif 3; other site 685039003659 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 685039003660 anticodon binding site; other site 685039003661 DNA polymerase III PolC; Validated; Region: polC; PRK00448 685039003662 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 685039003663 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 685039003664 generic binding surface II; other site 685039003665 generic binding surface I; other site 685039003666 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 685039003667 active site 685039003668 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 685039003669 active site 685039003670 catalytic site [active] 685039003671 substrate binding site [chemical binding]; other site 685039003672 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 685039003673 ribosome maturation protein RimP; Reviewed; Region: PRK00092 685039003674 Sm and related proteins; Region: Sm_like; cl00259 685039003675 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 685039003676 putative oligomer interface [polypeptide binding]; other site 685039003677 putative RNA binding site [nucleotide binding]; other site 685039003678 NusA N-terminal domain; Region: NusA_N; pfam08529 685039003679 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 685039003680 RNA binding site [nucleotide binding]; other site 685039003681 homodimer interface [polypeptide binding]; other site 685039003682 Transcription elongation factor [Transcription]; Region: NusA; COG0195 685039003683 NusA-like KH domain; Region: KH_5; pfam13184 685039003684 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 685039003685 G-X-X-G motif; other site 685039003686 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 685039003687 putative RNA binding cleft [nucleotide binding]; other site 685039003688 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 685039003689 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 685039003690 translation initiation factor IF-2; Region: IF-2; TIGR00487 685039003691 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 685039003692 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 685039003693 G1 box; other site 685039003694 putative GEF interaction site [polypeptide binding]; other site 685039003695 GTP/Mg2+ binding site [chemical binding]; other site 685039003696 Switch I region; other site 685039003697 G2 box; other site 685039003698 G3 box; other site 685039003699 Switch II region; other site 685039003700 G4 box; other site 685039003701 G5 box; other site 685039003702 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 685039003703 Translation-initiation factor 2; Region: IF-2; pfam11987 685039003704 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 685039003705 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 685039003706 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 685039003707 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 685039003708 RNA binding site [nucleotide binding]; other site 685039003709 active site 685039003710 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 685039003711 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 685039003712 active site 685039003713 Riboflavin kinase; Region: Flavokinase; smart00904 685039003714 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 685039003715 16S/18S rRNA binding site [nucleotide binding]; other site 685039003716 S13e-L30e interaction site [polypeptide binding]; other site 685039003717 25S rRNA binding site [nucleotide binding]; other site 685039003718 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 685039003719 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 685039003720 RNase E interface [polypeptide binding]; other site 685039003721 trimer interface [polypeptide binding]; other site 685039003722 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 685039003723 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 685039003724 RNase E interface [polypeptide binding]; other site 685039003725 trimer interface [polypeptide binding]; other site 685039003726 active site 685039003727 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 685039003728 putative nucleic acid binding region [nucleotide binding]; other site 685039003729 G-X-X-G motif; other site 685039003730 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 685039003731 RNA binding site [nucleotide binding]; other site 685039003732 domain interface; other site 685039003733 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 685039003734 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685039003735 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 685039003736 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 685039003737 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685039003738 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 685039003739 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 685039003740 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 685039003741 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 685039003742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 685039003743 DNA-binding site [nucleotide binding]; DNA binding site 685039003744 UTRA domain; Region: UTRA; pfam07702 685039003745 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 685039003746 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 685039003747 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 685039003748 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 685039003749 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 685039003750 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 685039003751 classical (c) SDRs; Region: SDR_c; cd05233 685039003752 NAD(P) binding site [chemical binding]; other site 685039003753 active site 685039003754 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 685039003755 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 685039003756 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 685039003757 Helix-turn-helix domain; Region: HTH_25; pfam13413 685039003758 sequence-specific DNA binding site [nucleotide binding]; other site 685039003759 salt bridge; other site 685039003760 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 685039003761 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 685039003762 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 685039003763 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 685039003764 putative MPT binding site; other site 685039003765 recombinase A; Provisional; Region: recA; PRK09354 685039003766 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 685039003767 hexamer interface [polypeptide binding]; other site 685039003768 Walker A motif; other site 685039003769 ATP binding site [chemical binding]; other site 685039003770 Walker B motif; other site 685039003771 phosphodiesterase; Provisional; Region: PRK12704 685039003772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685039003773 Zn2+ binding site [ion binding]; other site 685039003774 Mg2+ binding site [ion binding]; other site 685039003775 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 685039003776 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 685039003777 putative active site [active] 685039003778 metal binding site [ion binding]; metal-binding site 685039003779 homodimer binding site [polypeptide binding]; other site 685039003780 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 685039003781 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 685039003782 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 685039003783 dimer interface [polypeptide binding]; other site 685039003784 PYR/PP interface [polypeptide binding]; other site 685039003785 TPP binding site [chemical binding]; other site 685039003786 substrate binding site [chemical binding]; other site 685039003787 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 685039003788 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 685039003789 TPP-binding site [chemical binding]; other site 685039003790 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 685039003791 Uncharacterized conserved protein [Function unknown]; Region: COG0011 685039003792 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 685039003793 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 685039003794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685039003795 FeS/SAM binding site; other site 685039003796 TRAM domain; Region: TRAM; pfam01938 685039003797 Predicted membrane protein [Function unknown]; Region: COG4550 685039003798 Predicted membrane protein [Function unknown]; Region: COG4732 685039003799 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 685039003800 MutS domain I; Region: MutS_I; pfam01624 685039003801 MutS domain II; Region: MutS_II; pfam05188 685039003802 MutS domain III; Region: MutS_III; pfam05192 685039003803 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 685039003804 Walker A/P-loop; other site 685039003805 ATP binding site [chemical binding]; other site 685039003806 Q-loop/lid; other site 685039003807 ABC transporter signature motif; other site 685039003808 Walker B; other site 685039003809 D-loop; other site 685039003810 H-loop/switch region; other site 685039003811 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 685039003812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039003813 ATP binding site [chemical binding]; other site 685039003814 Mg2+ binding site [ion binding]; other site 685039003815 G-X-G motif; other site 685039003816 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 685039003817 ATP binding site [chemical binding]; other site 685039003818 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 685039003819 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 685039003820 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 685039003821 amphipathic channel; other site 685039003822 Asn-Pro-Ala signature motifs; other site 685039003823 glycerol kinase; Provisional; Region: glpK; PRK00047 685039003824 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 685039003825 N- and C-terminal domain interface [polypeptide binding]; other site 685039003826 active site 685039003827 MgATP binding site [chemical binding]; other site 685039003828 catalytic site [active] 685039003829 metal binding site [ion binding]; metal-binding site 685039003830 glycerol binding site [chemical binding]; other site 685039003831 homotetramer interface [polypeptide binding]; other site 685039003832 homodimer interface [polypeptide binding]; other site 685039003833 FBP binding site [chemical binding]; other site 685039003834 protein IIAGlc interface [polypeptide binding]; other site 685039003835 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 685039003836 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 685039003837 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685039003838 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 685039003839 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 685039003840 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 685039003841 bacterial Hfq-like; Region: Hfq; cd01716 685039003842 hexamer interface [polypeptide binding]; other site 685039003843 Sm1 motif; other site 685039003844 RNA binding site [nucleotide binding]; other site 685039003845 Sm2 motif; other site 685039003846 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 685039003847 catalytic residues [active] 685039003848 dimer interface [polypeptide binding]; other site 685039003849 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 685039003850 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 685039003851 HflX GTPase family; Region: HflX; cd01878 685039003852 G1 box; other site 685039003853 GTP/Mg2+ binding site [chemical binding]; other site 685039003854 Switch I region; other site 685039003855 G2 box; other site 685039003856 G3 box; other site 685039003857 Switch II region; other site 685039003858 G4 box; other site 685039003859 G5 box; other site 685039003860 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 685039003861 Aluminium resistance protein; Region: Alum_res; pfam06838 685039003862 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 685039003863 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685039003864 DNA binding residues [nucleotide binding] 685039003865 putative dimer interface [polypeptide binding]; other site 685039003866 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 685039003867 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 685039003868 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 685039003869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 685039003870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 685039003871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 685039003872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 685039003873 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 685039003874 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 685039003875 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685039003876 catalytic residue [active] 685039003877 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 685039003878 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 685039003879 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 685039003880 putative active site [active] 685039003881 catalytic site [active] 685039003882 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 685039003883 putative active site [active] 685039003884 catalytic site [active] 685039003885 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685039003886 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685039003887 Walker A/P-loop; other site 685039003888 ATP binding site [chemical binding]; other site 685039003889 Q-loop/lid; other site 685039003890 ABC transporter signature motif; other site 685039003891 Walker B; other site 685039003892 D-loop; other site 685039003893 H-loop/switch region; other site 685039003894 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685039003895 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685039003896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 685039003897 Histidine kinase; Region: HisKA_3; pfam07730 685039003898 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 685039003899 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685039003900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039003901 active site 685039003902 phosphorylation site [posttranslational modification] 685039003903 intermolecular recognition site; other site 685039003904 dimerization interface [polypeptide binding]; other site 685039003905 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685039003906 DNA binding residues [nucleotide binding] 685039003907 dimerization interface [polypeptide binding]; other site 685039003908 Staphylococcal nuclease homologues; Region: SNc; smart00318 685039003909 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 685039003910 Catalytic site; other site 685039003911 AAA domain; Region: AAA_11; pfam13086 685039003912 aspartate kinase; Reviewed; Region: PRK09034 685039003913 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 685039003914 putative catalytic residues [active] 685039003915 putative nucleotide binding site [chemical binding]; other site 685039003916 putative aspartate binding site [chemical binding]; other site 685039003917 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 685039003918 allosteric regulatory residue; other site 685039003919 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 685039003920 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 685039003921 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 685039003922 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 685039003923 threonine synthase; Reviewed; Region: PRK06721 685039003924 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 685039003925 homodimer interface [polypeptide binding]; other site 685039003926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039003927 catalytic residue [active] 685039003928 homoserine kinase; Provisional; Region: PRK01212 685039003929 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 685039003930 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 685039003931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039003932 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 685039003933 active site 685039003934 motif I; other site 685039003935 motif II; other site 685039003936 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 685039003937 lysine transporter; Provisional; Region: PRK10836 685039003938 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 685039003939 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 685039003940 tetramer interface [polypeptide binding]; other site 685039003941 heme binding pocket [chemical binding]; other site 685039003942 NADPH binding site [chemical binding]; other site 685039003943 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 685039003944 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 685039003945 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 685039003946 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 685039003947 active site 685039003948 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 685039003949 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 685039003950 LexA repressor; Validated; Region: PRK00215 685039003951 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685039003952 putative DNA binding site [nucleotide binding]; other site 685039003953 putative Zn2+ binding site [ion binding]; other site 685039003954 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 685039003955 Catalytic site [active] 685039003956 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 685039003957 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 685039003958 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 685039003959 TPP-binding site [chemical binding]; other site 685039003960 dimer interface [polypeptide binding]; other site 685039003961 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 685039003962 PYR/PP interface [polypeptide binding]; other site 685039003963 dimer interface [polypeptide binding]; other site 685039003964 TPP binding site [chemical binding]; other site 685039003965 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 685039003966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 685039003967 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 685039003968 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 685039003969 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 685039003970 active site 685039003971 metal binding site [ion binding]; metal-binding site 685039003972 DNA binding site [nucleotide binding] 685039003973 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 685039003974 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 685039003975 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 685039003976 Walker A/P-loop; other site 685039003977 ATP binding site [chemical binding]; other site 685039003978 Q-loop/lid; other site 685039003979 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 685039003980 ABC transporter signature motif; other site 685039003981 Walker B; other site 685039003982 D-loop; other site 685039003983 H-loop/switch region; other site 685039003984 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 685039003985 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 685039003986 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 685039003987 aconitate hydratase; Validated; Region: PRK09277 685039003988 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 685039003989 substrate binding site [chemical binding]; other site 685039003990 ligand binding site [chemical binding]; other site 685039003991 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 685039003992 substrate binding site [chemical binding]; other site 685039003993 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 685039003994 active site 685039003995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 685039003996 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 685039003997 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 685039003998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039003999 ATP binding site [chemical binding]; other site 685039004000 Mg2+ binding site [ion binding]; other site 685039004001 G-X-G motif; other site 685039004002 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 685039004003 anchoring element; other site 685039004004 dimer interface [polypeptide binding]; other site 685039004005 ATP binding site [chemical binding]; other site 685039004006 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 685039004007 active site 685039004008 putative metal-binding site [ion binding]; other site 685039004009 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 685039004010 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 685039004011 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 685039004012 CAP-like domain; other site 685039004013 active site 685039004014 primary dimer interface [polypeptide binding]; other site 685039004015 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685039004016 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 685039004017 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 685039004018 CAT RNA binding domain; Region: CAT_RBD; smart01061 685039004019 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 685039004020 PRD domain; Region: PRD; pfam00874 685039004021 PRD domain; Region: PRD; pfam00874 685039004022 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 685039004023 Domain of unknown function DUF20; Region: UPF0118; pfam01594 685039004024 Predicted integral membrane protein [Function unknown]; Region: COG0392 685039004025 Uncharacterized conserved protein [Function unknown]; Region: COG2898 685039004026 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 685039004027 methionine sulfoxide reductase A; Provisional; Region: PRK14054 685039004028 Transcriptional regulator [Transcription]; Region: LytR; COG1316 685039004029 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 685039004030 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 685039004031 active site 685039004032 DNA binding site [nucleotide binding] 685039004033 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 685039004034 prephenate dehydrogenase; Validated; Region: PRK06545 685039004035 prephenate dehydrogenase; Validated; Region: PRK08507 685039004036 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 685039004037 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 685039004038 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 685039004039 putative oligomer interface [polypeptide binding]; other site 685039004040 putative active site [active] 685039004041 metal binding site [ion binding]; metal-binding site 685039004042 anthranilate synthase component I; Provisional; Region: PRK13567 685039004043 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 685039004044 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 685039004045 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 685039004046 Glutamine amidotransferase class-I; Region: GATase; pfam00117 685039004047 glutamine binding [chemical binding]; other site 685039004048 catalytic triad [active] 685039004049 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 685039004050 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 685039004051 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 685039004052 active site 685039004053 ribulose/triose binding site [chemical binding]; other site 685039004054 phosphate binding site [ion binding]; other site 685039004055 substrate (anthranilate) binding pocket [chemical binding]; other site 685039004056 product (indole) binding pocket [chemical binding]; other site 685039004057 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 685039004058 active site 685039004059 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 685039004060 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 685039004061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039004062 catalytic residue [active] 685039004063 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 685039004064 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 685039004065 substrate binding site [chemical binding]; other site 685039004066 active site 685039004067 catalytic residues [active] 685039004068 heterodimer interface [polypeptide binding]; other site 685039004069 FemAB family; Region: FemAB; pfam02388 685039004070 FlxA-like protein; Region: FlxA; pfam14282 685039004071 FemAB family; Region: FemAB; pfam02388 685039004072 SWIM zinc finger; Region: SWIM; pfam04434 685039004073 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 685039004074 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685039004075 Walker A/P-loop; other site 685039004076 ATP binding site [chemical binding]; other site 685039004077 Q-loop/lid; other site 685039004078 ABC transporter signature motif; other site 685039004079 Walker B; other site 685039004080 D-loop; other site 685039004081 H-loop/switch region; other site 685039004082 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685039004083 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 685039004084 Walker A/P-loop; other site 685039004085 ATP binding site [chemical binding]; other site 685039004086 Q-loop/lid; other site 685039004087 ABC transporter signature motif; other site 685039004088 Walker B; other site 685039004089 D-loop; other site 685039004090 H-loop/switch region; other site 685039004091 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 685039004092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039004093 dimer interface [polypeptide binding]; other site 685039004094 conserved gate region; other site 685039004095 putative PBP binding loops; other site 685039004096 ABC-ATPase subunit interface; other site 685039004097 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685039004098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039004099 dimer interface [polypeptide binding]; other site 685039004100 conserved gate region; other site 685039004101 putative PBP binding loops; other site 685039004102 ABC-ATPase subunit interface; other site 685039004103 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 685039004104 oligoendopeptidase F; Region: pepF; TIGR00181 685039004105 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 685039004106 active site 685039004107 Zn binding site [ion binding]; other site 685039004108 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 685039004109 PhoU domain; Region: PhoU; pfam01895 685039004110 PhoU domain; Region: PhoU; pfam01895 685039004111 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 685039004112 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 685039004113 Walker A/P-loop; other site 685039004114 ATP binding site [chemical binding]; other site 685039004115 Q-loop/lid; other site 685039004116 ABC transporter signature motif; other site 685039004117 Walker B; other site 685039004118 D-loop; other site 685039004119 H-loop/switch region; other site 685039004120 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 685039004121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039004122 dimer interface [polypeptide binding]; other site 685039004123 conserved gate region; other site 685039004124 putative PBP binding loops; other site 685039004125 ABC-ATPase subunit interface; other site 685039004126 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 685039004127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039004128 dimer interface [polypeptide binding]; other site 685039004129 conserved gate region; other site 685039004130 ABC-ATPase subunit interface; other site 685039004131 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 685039004132 S1 domain; Region: S1_2; pfam13509 685039004133 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 685039004134 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685039004135 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685039004136 ABC transporter; Region: ABC_tran_2; pfam12848 685039004137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685039004138 aspartate kinase; Reviewed; Region: PRK06635 685039004139 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 685039004140 putative nucleotide binding site [chemical binding]; other site 685039004141 putative catalytic residues [active] 685039004142 putative Mg ion binding site [ion binding]; other site 685039004143 putative aspartate binding site [chemical binding]; other site 685039004144 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 685039004145 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 685039004146 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 685039004147 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 685039004148 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 685039004149 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 685039004150 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 685039004151 dimer interface [polypeptide binding]; other site 685039004152 active site 685039004153 catalytic residue [active] 685039004154 dihydrodipicolinate reductase; Provisional; Region: PRK00048 685039004155 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 685039004156 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 685039004157 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 685039004158 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 685039004159 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 685039004160 active site 685039004161 trimer interface [polypeptide binding]; other site 685039004162 substrate binding site [chemical binding]; other site 685039004163 CoA binding site [chemical binding]; other site 685039004164 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 685039004165 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 685039004166 metal binding site [ion binding]; metal-binding site 685039004167 dimer interface [polypeptide binding]; other site 685039004168 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 685039004169 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 685039004170 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685039004171 catalytic residue [active] 685039004172 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 685039004173 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 685039004174 active site 685039004175 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685039004176 substrate binding site [chemical binding]; other site 685039004177 catalytic residues [active] 685039004178 dimer interface [polypeptide binding]; other site 685039004179 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 685039004180 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685039004181 DNA-binding site [nucleotide binding]; DNA binding site 685039004182 RNA-binding motif; other site 685039004183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 685039004184 acylphosphatase; Provisional; Region: PRK14431 685039004185 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 685039004186 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 685039004187 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 685039004188 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 685039004189 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 685039004190 metal ion-dependent adhesion site (MIDAS); other site 685039004191 MoxR-like ATPases [General function prediction only]; Region: COG0714 685039004192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039004193 Walker A motif; other site 685039004194 ATP binding site [chemical binding]; other site 685039004195 Walker B motif; other site 685039004196 arginine finger; other site 685039004197 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 685039004198 active site 685039004199 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 685039004200 active site 685039004201 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 685039004202 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685039004203 E3 interaction surface; other site 685039004204 lipoyl attachment site [posttranslational modification]; other site 685039004205 e3 binding domain; Region: E3_binding; pfam02817 685039004206 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 685039004207 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 685039004208 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 685039004209 TPP-binding site [chemical binding]; other site 685039004210 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 685039004211 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 685039004212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685039004213 HAMP domain; Region: HAMP; pfam00672 685039004214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685039004215 dimer interface [polypeptide binding]; other site 685039004216 phosphorylation site [posttranslational modification] 685039004217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039004218 ATP binding site [chemical binding]; other site 685039004219 Mg2+ binding site [ion binding]; other site 685039004220 G-X-G motif; other site 685039004221 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685039004222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039004223 active site 685039004224 phosphorylation site [posttranslational modification] 685039004225 intermolecular recognition site; other site 685039004226 dimerization interface [polypeptide binding]; other site 685039004227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685039004228 DNA binding site [nucleotide binding] 685039004229 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 685039004230 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 685039004231 active site 685039004232 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 685039004233 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 685039004234 active site 685039004235 homodimer interface [polypeptide binding]; other site 685039004236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039004237 Coenzyme A binding pocket [chemical binding]; other site 685039004238 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 685039004239 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 685039004240 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 685039004241 protein binding site [polypeptide binding]; other site 685039004242 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 685039004243 Catalytic dyad [active] 685039004244 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 685039004245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 685039004246 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 685039004247 HPr interaction site; other site 685039004248 glycerol kinase (GK) interaction site [polypeptide binding]; other site 685039004249 active site 685039004250 phosphorylation site [posttranslational modification] 685039004251 methionine sulfoxide reductase B; Provisional; Region: PRK00222 685039004252 SelR domain; Region: SelR; pfam01641 685039004253 methionine sulfoxide reductase A; Provisional; Region: PRK13014 685039004254 EDD domain protein, DegV family; Region: DegV; TIGR00762 685039004255 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 685039004256 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 685039004257 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 685039004258 folate binding site [chemical binding]; other site 685039004259 NADP+ binding site [chemical binding]; other site 685039004260 thymidylate synthase; Region: thym_sym; TIGR03284 685039004261 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 685039004262 dimerization interface [polypeptide binding]; other site 685039004263 active site 685039004264 Disulphide isomerase; Region: Disulph_isomer; cl05813 685039004265 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 685039004266 Virulence factor; Region: Virulence_fact; pfam13769 685039004267 HEAT repeats; Region: HEAT_2; pfam13646 685039004268 HEAT repeat; Region: HEAT; pfam02985 685039004269 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 685039004270 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 685039004271 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 685039004272 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 685039004273 RNA/DNA hybrid binding site [nucleotide binding]; other site 685039004274 active site 685039004275 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685039004276 Amino acid permease; Region: AA_permease_2; pfam13520 685039004277 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 685039004278 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 685039004279 tetramer interface [polypeptide binding]; other site 685039004280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039004281 catalytic residue [active] 685039004282 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 685039004283 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 685039004284 hexamer interface [polypeptide binding]; other site 685039004285 ligand binding site [chemical binding]; other site 685039004286 putative active site [active] 685039004287 NAD(P) binding site [chemical binding]; other site 685039004288 5'-3' exonuclease; Region: 53EXOc; smart00475 685039004289 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 685039004290 active site 685039004291 metal binding site 1 [ion binding]; metal-binding site 685039004292 putative 5' ssDNA interaction site; other site 685039004293 metal binding site 3; metal-binding site 685039004294 metal binding site 2 [ion binding]; metal-binding site 685039004295 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 685039004296 putative DNA binding site [nucleotide binding]; other site 685039004297 putative metal binding site [ion binding]; other site 685039004298 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 685039004299 Dynamin family; Region: Dynamin_N; pfam00350 685039004300 G1 box; other site 685039004301 GTP/Mg2+ binding site [chemical binding]; other site 685039004302 G2 box; other site 685039004303 Switch I region; other site 685039004304 G3 box; other site 685039004305 Switch II region; other site 685039004306 G4 box; other site 685039004307 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 685039004308 Dynamin family; Region: Dynamin_N; pfam00350 685039004309 G1 box; other site 685039004310 GTP/Mg2+ binding site [chemical binding]; other site 685039004311 G2 box; other site 685039004312 Switch I region; other site 685039004313 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 685039004314 G3 box; other site 685039004315 Switch II region; other site 685039004316 GTP/Mg2+ binding site [chemical binding]; other site 685039004317 G4 box; other site 685039004318 G5 box; other site 685039004319 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 685039004320 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 685039004321 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 685039004322 Cobalt transport protein component CbiN; Region: CbiN; cl00842 685039004323 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 685039004324 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 685039004325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 685039004326 cell division protein GpsB; Provisional; Region: PRK14127 685039004327 DivIVA domain; Region: DivI1A_domain; TIGR03544 685039004328 hypothetical protein; Provisional; Region: PRK13660 685039004329 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 685039004330 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 685039004331 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 685039004332 Transglycosylase; Region: Transgly; pfam00912 685039004333 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 685039004334 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 685039004335 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 685039004336 minor groove reading motif; other site 685039004337 helix-hairpin-helix signature motif; other site 685039004338 substrate binding pocket [chemical binding]; other site 685039004339 active site 685039004340 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 685039004341 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 685039004342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 685039004343 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 685039004344 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 685039004345 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 685039004346 putative dimer interface [polypeptide binding]; other site 685039004347 putative anticodon binding site; other site 685039004348 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 685039004349 homodimer interface [polypeptide binding]; other site 685039004350 motif 1; other site 685039004351 motif 2; other site 685039004352 active site 685039004353 motif 3; other site 685039004354 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 685039004355 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 685039004356 active site 685039004357 catalytic site [active] 685039004358 substrate binding site [chemical binding]; other site 685039004359 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 685039004360 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 685039004361 Biotin operon repressor [Transcription]; Region: BirA; COG1654 685039004362 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 685039004363 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 685039004364 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 685039004365 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 685039004366 active site 685039004367 NTP binding site [chemical binding]; other site 685039004368 metal binding triad [ion binding]; metal-binding site 685039004369 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 685039004370 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 685039004371 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 685039004372 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 685039004373 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 685039004374 homodimer interface [polypeptide binding]; other site 685039004375 metal binding site [ion binding]; metal-binding site 685039004376 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 685039004377 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 685039004378 Uncharacterized conserved protein [Function unknown]; Region: COG5582 685039004379 UPF0302 domain; Region: UPF0302; pfam08864 685039004380 A short protein domain of unknown function; Region: IDEAL; smart00914 685039004381 TPR repeat; Region: TPR_11; pfam13414 685039004382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685039004383 binding surface 685039004384 TPR motif; other site 685039004385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685039004386 TPR motif; other site 685039004387 binding surface 685039004388 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 685039004389 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 685039004390 hinge; other site 685039004391 active site 685039004392 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 685039004393 active site 685039004394 NAD binding site [chemical binding]; other site 685039004395 metal binding site [ion binding]; metal-binding site 685039004396 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 685039004397 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 685039004398 Tetramer interface [polypeptide binding]; other site 685039004399 active site 685039004400 FMN-binding site [chemical binding]; other site 685039004401 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 685039004402 active site 685039004403 multimer interface [polypeptide binding]; other site 685039004404 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 685039004405 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 685039004406 substrate binding pocket [chemical binding]; other site 685039004407 chain length determination region; other site 685039004408 substrate-Mg2+ binding site; other site 685039004409 catalytic residues [active] 685039004410 aspartate-rich region 1; other site 685039004411 active site lid residues [active] 685039004412 aspartate-rich region 2; other site 685039004413 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 685039004414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039004415 S-adenosylmethionine binding site [chemical binding]; other site 685039004416 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 685039004417 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 685039004418 IHF dimer interface [polypeptide binding]; other site 685039004419 IHF - DNA interface [nucleotide binding]; other site 685039004420 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 685039004421 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 685039004422 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 685039004423 GTP-binding protein Der; Reviewed; Region: PRK00093 685039004424 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 685039004425 G1 box; other site 685039004426 GTP/Mg2+ binding site [chemical binding]; other site 685039004427 Switch I region; other site 685039004428 G2 box; other site 685039004429 Switch II region; other site 685039004430 G3 box; other site 685039004431 G4 box; other site 685039004432 G5 box; other site 685039004433 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 685039004434 G1 box; other site 685039004435 GTP/Mg2+ binding site [chemical binding]; other site 685039004436 Switch I region; other site 685039004437 G2 box; other site 685039004438 G3 box; other site 685039004439 Switch II region; other site 685039004440 G4 box; other site 685039004441 G5 box; other site 685039004442 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 685039004443 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 685039004444 RNA binding site [nucleotide binding]; other site 685039004445 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 685039004446 RNA binding site [nucleotide binding]; other site 685039004447 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 685039004448 RNA binding site [nucleotide binding]; other site 685039004449 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 685039004450 RNA binding site [nucleotide binding]; other site 685039004451 cytidylate kinase; Provisional; Region: cmk; PRK00023 685039004452 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 685039004453 CMP-binding site; other site 685039004454 The sites determining sugar specificity; other site 685039004455 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 685039004456 active site 685039004457 homotetramer interface [polypeptide binding]; other site 685039004458 homodimer interface [polypeptide binding]; other site 685039004459 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 685039004460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685039004461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039004462 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685039004463 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 685039004464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685039004465 ATP binding site [chemical binding]; other site 685039004466 putative Mg++ binding site [ion binding]; other site 685039004467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685039004468 nucleotide binding region [chemical binding]; other site 685039004469 ATP-binding site [chemical binding]; other site 685039004470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 685039004471 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 685039004472 Predicted membrane protein [Function unknown]; Region: COG3601 685039004473 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 685039004474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685039004475 dimerization interface [polypeptide binding]; other site 685039004476 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 685039004477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685039004478 dimer interface [polypeptide binding]; other site 685039004479 phosphorylation site [posttranslational modification] 685039004480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039004481 ATP binding site [chemical binding]; other site 685039004482 Mg2+ binding site [ion binding]; other site 685039004483 G-X-G motif; other site 685039004484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685039004485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039004486 active site 685039004487 phosphorylation site [posttranslational modification] 685039004488 intermolecular recognition site; other site 685039004489 dimerization interface [polypeptide binding]; other site 685039004490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685039004491 DNA binding site [nucleotide binding] 685039004492 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 685039004493 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685039004494 RNA binding surface [nucleotide binding]; other site 685039004495 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 685039004496 active site 685039004497 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 685039004498 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 685039004499 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 685039004500 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 685039004501 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 685039004502 active site 685039004503 Int/Topo IB signature motif; other site 685039004504 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 685039004505 metal binding site 2 [ion binding]; metal-binding site 685039004506 putative DNA binding helix; other site 685039004507 metal binding site 1 [ion binding]; metal-binding site 685039004508 dimer interface [polypeptide binding]; other site 685039004509 structural Zn2+ binding site [ion binding]; other site 685039004510 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 685039004511 dimer interface [polypeptide binding]; other site 685039004512 ADP-ribose binding site [chemical binding]; other site 685039004513 active site 685039004514 nudix motif; other site 685039004515 metal binding site [ion binding]; metal-binding site 685039004516 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685039004517 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685039004518 active site 685039004519 catalytic tetrad [active] 685039004520 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 685039004521 classical (c) SDRs; Region: SDR_c; cd05233 685039004522 NAD(P) binding site [chemical binding]; other site 685039004523 active site 685039004524 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 685039004525 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 685039004526 ribonuclease Z; Region: RNase_Z; TIGR02651 685039004527 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 685039004528 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 685039004529 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 685039004530 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685039004531 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 685039004532 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 685039004533 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 685039004534 Ca binding site [ion binding]; other site 685039004535 active site 685039004536 catalytic site [active] 685039004537 Transcriptional regulators [Transcription]; Region: PurR; COG1609 685039004538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685039004539 DNA binding site [nucleotide binding] 685039004540 domain linker motif; other site 685039004541 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 685039004542 putative ligand binding site [chemical binding]; other site 685039004543 putative dimerization interface [polypeptide binding]; other site 685039004544 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685039004545 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 685039004546 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 685039004547 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 685039004548 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 685039004549 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 685039004550 peptidase T-like protein; Region: PepT-like; TIGR01883 685039004551 metal binding site [ion binding]; metal-binding site 685039004552 putative dimer interface [polypeptide binding]; other site 685039004553 Predicted membrane protein [Function unknown]; Region: COG4129 685039004554 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 685039004555 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 685039004556 Disulphide isomerase; Region: Disulph_isomer; pfam06491 685039004557 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685039004558 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 685039004559 E3 interaction surface; other site 685039004560 lipoyl attachment site [posttranslational modification]; other site 685039004561 e3 binding domain; Region: E3_binding; pfam02817 685039004562 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 685039004563 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 685039004564 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 685039004565 alpha subunit interface [polypeptide binding]; other site 685039004566 TPP binding site [chemical binding]; other site 685039004567 heterodimer interface [polypeptide binding]; other site 685039004568 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 685039004569 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 685039004570 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 685039004571 tetramer interface [polypeptide binding]; other site 685039004572 TPP-binding site [chemical binding]; other site 685039004573 heterodimer interface [polypeptide binding]; other site 685039004574 phosphorylation loop region [posttranslational modification] 685039004575 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 685039004576 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 685039004577 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039004578 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 685039004579 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 685039004580 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 685039004581 Walker A/P-loop; other site 685039004582 ATP binding site [chemical binding]; other site 685039004583 Q-loop/lid; other site 685039004584 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 685039004585 ABC transporter signature motif; other site 685039004586 Walker B; other site 685039004587 D-loop; other site 685039004588 H-loop/switch region; other site 685039004589 arginine repressor; Provisional; Region: PRK04280 685039004590 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 685039004591 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 685039004592 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 685039004593 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 685039004594 substrate binding pocket [chemical binding]; other site 685039004595 chain length determination region; other site 685039004596 substrate-Mg2+ binding site; other site 685039004597 catalytic residues [active] 685039004598 aspartate-rich region 1; other site 685039004599 active site lid residues [active] 685039004600 aspartate-rich region 2; other site 685039004601 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 685039004602 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 685039004603 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 685039004604 generic binding surface II; other site 685039004605 generic binding surface I; other site 685039004606 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 685039004607 putative RNA binding site [nucleotide binding]; other site 685039004608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 685039004609 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 685039004610 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685039004611 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 685039004612 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 685039004613 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 685039004614 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 685039004615 carboxyltransferase (CT) interaction site; other site 685039004616 biotinylation site [posttranslational modification]; other site 685039004617 elongation factor P; Validated; Region: PRK00529 685039004618 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 685039004619 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 685039004620 RNA binding site [nucleotide binding]; other site 685039004621 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 685039004622 RNA binding site [nucleotide binding]; other site 685039004623 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 685039004624 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 685039004625 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 685039004626 active site 685039004627 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 685039004628 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 685039004629 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685039004630 active site residue [active] 685039004631 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 685039004632 tetramer interface [polypeptide binding]; other site 685039004633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039004634 catalytic residue [active] 685039004635 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 685039004636 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 685039004637 tetramer interface [polypeptide binding]; other site 685039004638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039004639 catalytic residue [active] 685039004640 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 685039004641 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 685039004642 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 685039004643 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 685039004644 ADP binding site [chemical binding]; other site 685039004645 magnesium binding site [ion binding]; other site 685039004646 putative shikimate binding site; other site 685039004647 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 685039004648 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 685039004649 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 685039004650 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 685039004651 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 685039004652 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 685039004653 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 685039004654 Type II/IV secretion system protein; Region: T2SE; pfam00437 685039004655 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 685039004656 Walker A motif; other site 685039004657 ATP binding site [chemical binding]; other site 685039004658 Walker B motif; other site 685039004659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685039004660 Uncharacterized conserved protein [Function unknown]; Region: COG0011 685039004661 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 685039004662 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 685039004663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 685039004664 Rhomboid family; Region: Rhomboid; pfam01694 685039004665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685039004666 binding surface 685039004667 TPR motif; other site 685039004668 Tetratricopeptide repeat; Region: TPR_16; pfam13432 685039004669 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 685039004670 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 685039004671 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 685039004672 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 685039004673 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 685039004674 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685039004675 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 685039004676 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 685039004677 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 685039004678 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 685039004679 metal binding site 2 [ion binding]; metal-binding site 685039004680 putative DNA binding helix; other site 685039004681 metal binding site 1 [ion binding]; metal-binding site 685039004682 dimer interface [polypeptide binding]; other site 685039004683 structural Zn2+ binding site [ion binding]; other site 685039004684 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 685039004685 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039004686 ABC-ATPase subunit interface; other site 685039004687 dimer interface [polypeptide binding]; other site 685039004688 putative PBP binding regions; other site 685039004689 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 685039004690 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 685039004691 endonuclease IV; Provisional; Region: PRK01060 685039004692 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 685039004693 AP (apurinic/apyrimidinic) site pocket; other site 685039004694 DNA interaction; other site 685039004695 Metal-binding active site; metal-binding site 685039004696 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 685039004697 DEAD-like helicases superfamily; Region: DEXDc; smart00487 685039004698 ATP binding site [chemical binding]; other site 685039004699 putative Mg++ binding site [ion binding]; other site 685039004700 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685039004701 nucleotide binding region [chemical binding]; other site 685039004702 ATP-binding site [chemical binding]; other site 685039004703 Uncharacterized conserved protein [Function unknown]; Region: COG0327 685039004704 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 685039004705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 685039004706 Uncharacterized conserved protein [Function unknown]; Region: COG0327 685039004707 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 685039004708 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 685039004709 Family of unknown function (DUF633); Region: DUF633; pfam04816 685039004710 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 685039004711 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 685039004712 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 685039004713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685039004714 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 685039004715 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685039004716 DNA binding residues [nucleotide binding] 685039004717 DNA primase, catalytic core; Region: dnaG; TIGR01391 685039004718 CHC2 zinc finger; Region: zf-CHC2; pfam01807 685039004719 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 685039004720 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 685039004721 active site 685039004722 metal binding site [ion binding]; metal-binding site 685039004723 interdomain interaction site; other site 685039004724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 685039004725 FOG: CBS domain [General function prediction only]; Region: COG0517 685039004726 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 685039004727 glycyl-tRNA synthetase; Provisional; Region: PRK04173 685039004728 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 685039004729 motif 1; other site 685039004730 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 685039004731 active site 685039004732 motif 2; other site 685039004733 motif 3; other site 685039004734 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 685039004735 anticodon binding site; other site 685039004736 DNA repair protein RecO; Region: reco; TIGR00613 685039004737 Recombination protein O N terminal; Region: RecO_N; pfam11967 685039004738 Recombination protein O C terminal; Region: RecO_C; pfam02565 685039004739 GTPase Era; Reviewed; Region: era; PRK00089 685039004740 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 685039004741 G1 box; other site 685039004742 GTP/Mg2+ binding site [chemical binding]; other site 685039004743 Switch I region; other site 685039004744 G2 box; other site 685039004745 Switch II region; other site 685039004746 G3 box; other site 685039004747 G4 box; other site 685039004748 G5 box; other site 685039004749 KH domain; Region: KH_2; pfam07650 685039004750 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 685039004751 active site 685039004752 catalytic motif [active] 685039004753 Zn binding site [ion binding]; other site 685039004754 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 685039004755 metal-binding heat shock protein; Provisional; Region: PRK00016 685039004756 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 685039004757 PhoH-like protein; Region: PhoH; pfam02562 685039004758 hypothetical protein; Provisional; Region: PRK13665 685039004759 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 685039004760 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 685039004761 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 685039004762 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 685039004763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685039004764 FeS/SAM binding site; other site 685039004765 TRAM domain; Region: TRAM; cl01282 685039004766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 685039004767 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 685039004768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039004769 S-adenosylmethionine binding site [chemical binding]; other site 685039004770 chaperone protein DnaJ; Provisional; Region: PRK14280 685039004771 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 685039004772 HSP70 interaction site [polypeptide binding]; other site 685039004773 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 685039004774 substrate binding site [polypeptide binding]; other site 685039004775 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 685039004776 Zn binding sites [ion binding]; other site 685039004777 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 685039004778 dimer interface [polypeptide binding]; other site 685039004779 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 685039004780 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 685039004781 nucleotide binding site [chemical binding]; other site 685039004782 NEF interaction site [polypeptide binding]; other site 685039004783 SBD interface [polypeptide binding]; other site 685039004784 heat shock protein GrpE; Provisional; Region: PRK14140 685039004785 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 685039004786 dimer interface [polypeptide binding]; other site 685039004787 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 685039004788 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 685039004789 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 685039004790 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 685039004791 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 685039004792 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685039004793 FeS/SAM binding site; other site 685039004794 HemN C-terminal domain; Region: HemN_C; pfam06969 685039004795 GTP-binding protein LepA; Provisional; Region: PRK05433 685039004796 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 685039004797 G1 box; other site 685039004798 putative GEF interaction site [polypeptide binding]; other site 685039004799 GTP/Mg2+ binding site [chemical binding]; other site 685039004800 Switch I region; other site 685039004801 G2 box; other site 685039004802 G3 box; other site 685039004803 Switch II region; other site 685039004804 G4 box; other site 685039004805 G5 box; other site 685039004806 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 685039004807 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 685039004808 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 685039004809 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 685039004810 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 685039004811 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 685039004812 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 685039004813 Competence protein; Region: Competence; pfam03772 685039004814 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 685039004815 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685039004816 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 685039004817 catalytic motif [active] 685039004818 Zn binding site [ion binding]; other site 685039004819 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 685039004820 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 685039004821 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685039004822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039004823 S-adenosylmethionine binding site [chemical binding]; other site 685039004824 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 685039004825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685039004826 Zn2+ binding site [ion binding]; other site 685039004827 Mg2+ binding site [ion binding]; other site 685039004828 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 685039004829 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 685039004830 active site 685039004831 (T/H)XGH motif; other site 685039004832 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 685039004833 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 685039004834 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 685039004835 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 685039004836 shikimate binding site; other site 685039004837 NAD(P) binding site [chemical binding]; other site 685039004838 GTPase YqeH; Provisional; Region: PRK13796 685039004839 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 685039004840 GTP/Mg2+ binding site [chemical binding]; other site 685039004841 G4 box; other site 685039004842 G5 box; other site 685039004843 G1 box; other site 685039004844 Switch I region; other site 685039004845 G2 box; other site 685039004846 G3 box; other site 685039004847 Switch II region; other site 685039004848 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 685039004849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039004850 active site 685039004851 motif I; other site 685039004852 motif II; other site 685039004853 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 685039004854 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 685039004855 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 685039004856 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 685039004857 Fic family protein [Function unknown]; Region: COG3177 685039004858 Fic/DOC family; Region: Fic; pfam02661 685039004859 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 685039004860 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 685039004861 putative active site [active] 685039004862 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685039004863 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 685039004864 ATP-grasp domain; Region: ATP-grasp_4; cl17255 685039004865 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 685039004866 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 685039004867 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 685039004868 carboxyltransferase (CT) interaction site; other site 685039004869 biotinylation site [posttranslational modification]; other site 685039004870 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 685039004871 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 685039004872 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 685039004873 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 685039004874 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 685039004875 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 685039004876 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 685039004877 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 685039004878 Sugar specificity; other site 685039004879 Pyrimidine base specificity; other site 685039004880 ATP-binding site [chemical binding]; other site 685039004881 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 685039004882 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685039004883 Peptidase family U32; Region: Peptidase_U32; pfam01136 685039004884 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 685039004885 Peptidase family U32; Region: Peptidase_U32; pfam01136 685039004886 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 685039004887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039004888 S-adenosylmethionine binding site [chemical binding]; other site 685039004889 hypothetical protein; Provisional; Region: PRK13678 685039004890 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 685039004891 hypothetical protein; Provisional; Region: PRK05473 685039004892 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 685039004893 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 685039004894 motif 1; other site 685039004895 active site 685039004896 motif 2; other site 685039004897 motif 3; other site 685039004898 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 685039004899 DHHA1 domain; Region: DHHA1; pfam02272 685039004900 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 685039004901 AAA domain; Region: AAA_30; pfam13604 685039004902 Family description; Region: UvrD_C_2; pfam13538 685039004903 Tetratricopeptide repeat; Region: TPR_12; pfam13424 685039004904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685039004905 binding surface 685039004906 TPR motif; other site 685039004907 TPR repeat; Region: TPR_11; pfam13414 685039004908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685039004909 binding surface 685039004910 TPR motif; other site 685039004911 TPR repeat; Region: TPR_11; pfam13414 685039004912 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 685039004913 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 685039004914 Ligand Binding Site [chemical binding]; other site 685039004915 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 685039004916 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 685039004917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685039004918 catalytic residue [active] 685039004919 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 685039004920 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685039004921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 685039004922 Predicted transcriptional regulator [Transcription]; Region: COG1959 685039004923 Transcriptional regulator; Region: Rrf2; pfam02082 685039004924 recombination factor protein RarA; Reviewed; Region: PRK13342 685039004925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039004926 Walker A motif; other site 685039004927 ATP binding site [chemical binding]; other site 685039004928 Walker B motif; other site 685039004929 arginine finger; other site 685039004930 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 685039004931 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 685039004932 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 685039004933 putative ATP binding site [chemical binding]; other site 685039004934 putative substrate interface [chemical binding]; other site 685039004935 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 685039004936 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 685039004937 dimer interface [polypeptide binding]; other site 685039004938 anticodon binding site; other site 685039004939 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 685039004940 homodimer interface [polypeptide binding]; other site 685039004941 motif 1; other site 685039004942 active site 685039004943 motif 2; other site 685039004944 GAD domain; Region: GAD; pfam02938 685039004945 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 685039004946 motif 3; other site 685039004947 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 685039004948 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 685039004949 dimer interface [polypeptide binding]; other site 685039004950 motif 1; other site 685039004951 active site 685039004952 motif 2; other site 685039004953 motif 3; other site 685039004954 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 685039004955 anticodon binding site; other site 685039004956 Bacterial SH3 domain homologues; Region: SH3b; smart00287 685039004957 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 685039004958 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 685039004959 active site 685039004960 metal binding site [ion binding]; metal-binding site 685039004961 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 685039004962 putative active site [active] 685039004963 dimerization interface [polypeptide binding]; other site 685039004964 putative tRNAtyr binding site [nucleotide binding]; other site 685039004965 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 685039004966 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685039004967 Zn2+ binding site [ion binding]; other site 685039004968 Mg2+ binding site [ion binding]; other site 685039004969 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 685039004970 synthetase active site [active] 685039004971 NTP binding site [chemical binding]; other site 685039004972 metal binding site [ion binding]; metal-binding site 685039004973 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 685039004974 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 685039004975 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685039004976 active site 685039004977 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 685039004978 DHH family; Region: DHH; pfam01368 685039004979 DHHA1 domain; Region: DHHA1; pfam02272 685039004980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 685039004981 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 685039004982 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 685039004983 Protein export membrane protein; Region: SecD_SecF; cl14618 685039004984 Protein export membrane protein; Region: SecD_SecF; pfam02355 685039004985 Preprotein translocase subunit; Region: YajC; pfam02699 685039004986 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 685039004987 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 685039004988 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 685039004989 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 685039004990 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 685039004991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039004992 Walker A motif; other site 685039004993 ATP binding site [chemical binding]; other site 685039004994 Walker B motif; other site 685039004995 arginine finger; other site 685039004996 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 685039004997 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 685039004998 RuvA N terminal domain; Region: RuvA_N; pfam01330 685039004999 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 685039005000 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 685039005001 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 685039005002 GTPase CgtA; Reviewed; Region: obgE; PRK12297 685039005003 GTP1/OBG; Region: GTP1_OBG; pfam01018 685039005004 Obg GTPase; Region: Obg; cd01898 685039005005 G1 box; other site 685039005006 GTP/Mg2+ binding site [chemical binding]; other site 685039005007 Switch I region; other site 685039005008 G2 box; other site 685039005009 G3 box; other site 685039005010 Switch II region; other site 685039005011 G4 box; other site 685039005012 G5 box; other site 685039005013 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 685039005014 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 685039005015 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 685039005016 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 685039005017 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 685039005018 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 685039005019 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 685039005020 rod shape-determining protein MreC; Region: MreC; pfam04085 685039005021 hypothetical protein; Reviewed; Region: PRK00024 685039005022 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 685039005023 MPN+ (JAMM) motif; other site 685039005024 Zinc-binding site [ion binding]; other site 685039005025 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 685039005026 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 685039005027 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 685039005028 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 685039005029 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685039005030 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685039005031 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 685039005032 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 685039005033 active site 685039005034 HIGH motif; other site 685039005035 nucleotide binding site [chemical binding]; other site 685039005036 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 685039005037 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 685039005038 active site 685039005039 KMSKS motif; other site 685039005040 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 685039005041 tRNA binding surface [nucleotide binding]; other site 685039005042 anticodon binding site; other site 685039005043 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 685039005044 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 685039005045 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 685039005046 Putative ammonia monooxygenase; Region: AmoA; pfam05145 685039005047 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 685039005048 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 685039005049 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685039005050 inhibitor-cofactor binding pocket; inhibition site 685039005051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039005052 catalytic residue [active] 685039005053 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 685039005054 dimer interface [polypeptide binding]; other site 685039005055 active site 685039005056 Schiff base residues; other site 685039005057 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 685039005058 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 685039005059 active site 685039005060 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 685039005061 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 685039005062 domain interfaces; other site 685039005063 active site 685039005064 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 685039005065 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 685039005066 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 685039005067 tRNA; other site 685039005068 putative tRNA binding site [nucleotide binding]; other site 685039005069 putative NADP binding site [chemical binding]; other site 685039005070 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 685039005071 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 685039005072 G1 box; other site 685039005073 GTP/Mg2+ binding site [chemical binding]; other site 685039005074 Switch I region; other site 685039005075 G2 box; other site 685039005076 G3 box; other site 685039005077 Switch II region; other site 685039005078 G4 box; other site 685039005079 G5 box; other site 685039005080 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 685039005081 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 685039005082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039005083 Walker A motif; other site 685039005084 ATP binding site [chemical binding]; other site 685039005085 Walker B motif; other site 685039005086 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 685039005087 trigger factor; Provisional; Region: tig; PRK01490 685039005088 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 685039005089 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 685039005090 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 685039005091 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 685039005092 23S rRNA binding site [nucleotide binding]; other site 685039005093 L21 binding site [polypeptide binding]; other site 685039005094 L13 binding site [polypeptide binding]; other site 685039005095 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 685039005096 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 685039005097 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 685039005098 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 685039005099 lysine transporter; Provisional; Region: PRK10836 685039005100 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 685039005101 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 685039005102 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 685039005103 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 685039005104 active site 685039005105 dimer interface [polypeptide binding]; other site 685039005106 motif 1; other site 685039005107 motif 2; other site 685039005108 motif 3; other site 685039005109 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 685039005110 anticodon binding site; other site 685039005111 primosomal protein DnaI; Reviewed; Region: PRK08939 685039005112 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 685039005113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039005114 Walker A motif; other site 685039005115 ATP binding site [chemical binding]; other site 685039005116 Walker B motif; other site 685039005117 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 685039005118 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 685039005119 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 685039005120 ATP cone domain; Region: ATP-cone; pfam03477 685039005121 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 685039005122 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 685039005123 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 685039005124 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 685039005125 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 685039005126 CoA-binding site [chemical binding]; other site 685039005127 ATP-binding [chemical binding]; other site 685039005128 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 685039005129 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 685039005130 DNA binding site [nucleotide binding] 685039005131 catalytic residue [active] 685039005132 H2TH interface [polypeptide binding]; other site 685039005133 putative catalytic residues [active] 685039005134 turnover-facilitating residue; other site 685039005135 intercalation triad [nucleotide binding]; other site 685039005136 8OG recognition residue [nucleotide binding]; other site 685039005137 putative reading head residues; other site 685039005138 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 685039005139 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 685039005140 DNA polymerase I; Provisional; Region: PRK05755 685039005141 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 685039005142 active site 685039005143 metal binding site 1 [ion binding]; metal-binding site 685039005144 putative 5' ssDNA interaction site; other site 685039005145 metal binding site 3; metal-binding site 685039005146 metal binding site 2 [ion binding]; metal-binding site 685039005147 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 685039005148 putative DNA binding site [nucleotide binding]; other site 685039005149 putative metal binding site [ion binding]; other site 685039005150 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 685039005151 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 685039005152 active site 685039005153 DNA binding site [nucleotide binding] 685039005154 catalytic site [active] 685039005155 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 685039005156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685039005157 dimer interface [polypeptide binding]; other site 685039005158 phosphorylation site [posttranslational modification] 685039005159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039005160 ATP binding site [chemical binding]; other site 685039005161 Mg2+ binding site [ion binding]; other site 685039005162 G-X-G motif; other site 685039005163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685039005164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039005165 active site 685039005166 phosphorylation site [posttranslational modification] 685039005167 intermolecular recognition site; other site 685039005168 dimerization interface [polypeptide binding]; other site 685039005169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685039005170 DNA binding site [nucleotide binding] 685039005171 isocitrate dehydrogenase; Reviewed; Region: PRK07006 685039005172 isocitrate dehydrogenase; Validated; Region: PRK07362 685039005173 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 685039005174 dimer interface [polypeptide binding]; other site 685039005175 Citrate synthase; Region: Citrate_synt; pfam00285 685039005176 active site 685039005177 citrylCoA binding site [chemical binding]; other site 685039005178 oxalacetate/citrate binding site [chemical binding]; other site 685039005179 coenzyme A binding site [chemical binding]; other site 685039005180 catalytic triad [active] 685039005181 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 685039005182 pyruvate kinase; Provisional; Region: PRK06354 685039005183 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 685039005184 domain interfaces; other site 685039005185 active site 685039005186 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 685039005187 6-phosphofructokinase; Provisional; Region: PRK03202 685039005188 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 685039005189 active site 685039005190 ADP/pyrophosphate binding site [chemical binding]; other site 685039005191 dimerization interface [polypeptide binding]; other site 685039005192 allosteric effector site; other site 685039005193 fructose-1,6-bisphosphate binding site; other site 685039005194 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 685039005195 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 685039005196 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 685039005197 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 685039005198 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 685039005199 Malic enzyme, N-terminal domain; Region: malic; pfam00390 685039005200 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 685039005201 putative NAD(P) binding site [chemical binding]; other site 685039005202 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 685039005203 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 685039005204 active site 685039005205 PHP Thumb interface [polypeptide binding]; other site 685039005206 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 685039005207 generic binding surface I; other site 685039005208 generic binding surface II; other site 685039005209 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 685039005210 DHH family; Region: DHH; pfam01368 685039005211 DHHA1 domain; Region: DHHA1; pfam02272 685039005212 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 685039005213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 685039005214 DNA-binding site [nucleotide binding]; DNA binding site 685039005215 DRTGG domain; Region: DRTGG; pfam07085 685039005216 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 685039005217 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 685039005218 active site 2 [active] 685039005219 active site 1 [active] 685039005220 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685039005221 Ligand Binding Site [chemical binding]; other site 685039005222 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 685039005223 metal-dependent hydrolase; Provisional; Region: PRK00685 685039005224 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 685039005225 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 685039005226 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 685039005227 active site 685039005228 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 685039005229 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 685039005230 hexamer interface [polypeptide binding]; other site 685039005231 ligand binding site [chemical binding]; other site 685039005232 putative active site [active] 685039005233 NAD(P) binding site [chemical binding]; other site 685039005234 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685039005235 Ligand Binding Site [chemical binding]; other site 685039005236 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 685039005237 propionate/acetate kinase; Provisional; Region: PRK12379 685039005238 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 685039005239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039005240 S-adenosylmethionine binding site [chemical binding]; other site 685039005241 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 685039005242 dimer interface [polypeptide binding]; other site 685039005243 catalytic triad [active] 685039005244 peroxidatic and resolving cysteines [active] 685039005245 hypothetical protein; Provisional; Region: PRK10621 685039005246 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 685039005247 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 685039005248 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 685039005249 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 685039005250 Ligand Binding Site [chemical binding]; other site 685039005251 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 685039005252 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 685039005253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685039005254 catalytic residue [active] 685039005255 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 685039005256 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 685039005257 GAF domain; Region: GAF_2; pfam13185 685039005258 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 685039005259 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 685039005260 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685039005261 RNA binding surface [nucleotide binding]; other site 685039005262 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 685039005263 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 685039005264 active site 685039005265 catalytic site [active] 685039005266 OsmC-like protein; Region: OsmC; cl00767 685039005267 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 685039005268 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685039005269 catalytic residue [active] 685039005270 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 685039005271 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 685039005272 ligand binding site [chemical binding]; other site 685039005273 NAD binding site [chemical binding]; other site 685039005274 dimerization interface [polypeptide binding]; other site 685039005275 catalytic site [active] 685039005276 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 685039005277 putative L-serine binding site [chemical binding]; other site 685039005278 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 685039005279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039005280 motif II; other site 685039005281 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 685039005282 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685039005283 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685039005284 active site turn [active] 685039005285 phosphorylation site [posttranslational modification] 685039005286 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 685039005287 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 685039005288 putative acyl-acceptor binding pocket; other site 685039005289 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 685039005290 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685039005291 protein binding site [polypeptide binding]; other site 685039005292 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 685039005293 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 685039005294 active site 685039005295 HIGH motif; other site 685039005296 dimer interface [polypeptide binding]; other site 685039005297 KMSKS motif; other site 685039005298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685039005299 RNA binding surface [nucleotide binding]; other site 685039005300 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 685039005301 Transglycosylase; Region: Transgly; pfam00912 685039005302 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 685039005303 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 685039005304 NEAr Transporter domain; Region: NEAT; smart00725 685039005305 NEAr Transporter domain; Region: NEAT; smart00725 685039005306 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 685039005307 heme-binding site [chemical binding]; other site 685039005308 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 685039005309 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 685039005310 Potassium binding sites [ion binding]; other site 685039005311 Cesium cation binding sites [ion binding]; other site 685039005312 acetyl-CoA synthetase; Provisional; Region: PRK04319 685039005313 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 685039005314 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 685039005315 active site 685039005316 acyl-activating enzyme (AAE) consensus motif; other site 685039005317 putative CoA binding site [chemical binding]; other site 685039005318 AMP binding site [chemical binding]; other site 685039005319 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 685039005320 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 685039005321 active site 685039005322 Zn binding site [ion binding]; other site 685039005323 catabolite control protein A; Region: ccpA; TIGR01481 685039005324 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685039005325 DNA binding site [nucleotide binding] 685039005326 domain linker motif; other site 685039005327 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 685039005328 dimerization interface [polypeptide binding]; other site 685039005329 effector binding site; other site 685039005330 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 685039005331 Chorismate mutase type II; Region: CM_2; cl00693 685039005332 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 685039005333 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 685039005334 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 685039005335 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685039005336 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685039005337 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685039005338 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 685039005339 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685039005340 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 685039005341 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 685039005342 putative tRNA-binding site [nucleotide binding]; other site 685039005343 hypothetical protein; Provisional; Region: PRK13668 685039005344 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 685039005345 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 685039005346 catalytic residues [active] 685039005347 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 685039005348 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 685039005349 oligomer interface [polypeptide binding]; other site 685039005350 active site 685039005351 metal binding site [ion binding]; metal-binding site 685039005352 Predicted small secreted protein [Function unknown]; Region: COG5584 685039005353 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 685039005354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039005355 S-adenosylmethionine binding site [chemical binding]; other site 685039005356 Phosphotransferase enzyme family; Region: APH; pfam01636 685039005357 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 685039005358 active site 685039005359 substrate binding site [chemical binding]; other site 685039005360 ATP binding site [chemical binding]; other site 685039005361 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 685039005362 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 685039005363 homodimer interface [polypeptide binding]; other site 685039005364 substrate-cofactor binding pocket; other site 685039005365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039005366 catalytic residue [active] 685039005367 dipeptidase PepV; Reviewed; Region: PRK07318 685039005368 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 685039005369 active site 685039005370 metal binding site [ion binding]; metal-binding site 685039005371 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 685039005372 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685039005373 RNA binding surface [nucleotide binding]; other site 685039005374 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 685039005375 active site 685039005376 uracil binding [chemical binding]; other site 685039005377 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 685039005378 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 685039005379 HI0933-like protein; Region: HI0933_like; pfam03486 685039005380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685039005381 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 685039005382 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 685039005383 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005384 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005385 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005386 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005387 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005388 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005389 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005390 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005391 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005392 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005393 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005394 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005395 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005396 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005397 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039005398 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685039005399 active site residue [active] 685039005400 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 685039005401 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 685039005402 HIGH motif; other site 685039005403 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 685039005404 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 685039005405 active site 685039005406 KMSKS motif; other site 685039005407 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 685039005408 tRNA binding surface [nucleotide binding]; other site 685039005409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039005410 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039005411 putative substrate translocation pore; other site 685039005412 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 685039005413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039005414 S-adenosylmethionine binding site [chemical binding]; other site 685039005415 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 685039005416 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 685039005417 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685039005418 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 685039005419 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 685039005420 homopentamer interface [polypeptide binding]; other site 685039005421 active site 685039005422 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 685039005423 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 685039005424 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 685039005425 dimerization interface [polypeptide binding]; other site 685039005426 active site 685039005427 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 685039005428 Lumazine binding domain; Region: Lum_binding; pfam00677 685039005429 Lumazine binding domain; Region: Lum_binding; pfam00677 685039005430 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 685039005431 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 685039005432 catalytic motif [active] 685039005433 Zn binding site [ion binding]; other site 685039005434 RibD C-terminal domain; Region: RibD_C; cl17279 685039005435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 685039005436 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 685039005437 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685039005438 dimerization interface [polypeptide binding]; other site 685039005439 putative DNA binding site [nucleotide binding]; other site 685039005440 putative Zn2+ binding site [ion binding]; other site 685039005441 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 685039005442 arsenical pump membrane protein; Provisional; Region: PRK15445 685039005443 transmembrane helices; other site 685039005444 Low molecular weight phosphatase family; Region: LMWPc; cd00115 685039005445 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 685039005446 active site 685039005447 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 685039005448 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 685039005449 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 685039005450 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 685039005451 DNA binding residues [nucleotide binding] 685039005452 CAAX protease self-immunity; Region: Abi; pfam02517 685039005453 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 685039005454 active site 685039005455 intersubunit interactions; other site 685039005456 catalytic residue [active] 685039005457 camphor resistance protein CrcB; Provisional; Region: PRK14201 685039005458 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 685039005459 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685039005460 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685039005461 active site 685039005462 catalytic tetrad [active] 685039005463 S-adenosylmethionine synthetase; Validated; Region: PRK05250 685039005464 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 685039005465 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 685039005466 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 685039005467 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 685039005468 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 685039005469 active site 685039005470 substrate-binding site [chemical binding]; other site 685039005471 metal-binding site [ion binding] 685039005472 ATP binding site [chemical binding]; other site 685039005473 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 685039005474 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685039005475 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 685039005476 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 685039005477 nudix motif; other site 685039005478 Haemolytic domain; Region: Haemolytic; pfam01809 685039005479 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 685039005480 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 685039005481 metal binding site [ion binding]; metal-binding site 685039005482 substrate binding pocket [chemical binding]; other site 685039005483 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 685039005484 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 685039005485 acyl-activating enzyme (AAE) consensus motif; other site 685039005486 putative AMP binding site [chemical binding]; other site 685039005487 putative active site [active] 685039005488 putative CoA binding site [chemical binding]; other site 685039005489 Excalibur calcium-binding domain; Region: Excalibur; smart00894 685039005490 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 685039005491 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 685039005492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039005493 Walker A/P-loop; other site 685039005494 ATP binding site [chemical binding]; other site 685039005495 ABC transporter; Region: ABC_tran; pfam00005 685039005496 Q-loop/lid; other site 685039005497 ABC transporter signature motif; other site 685039005498 Walker B; other site 685039005499 D-loop; other site 685039005500 H-loop/switch region; other site 685039005501 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 685039005502 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 685039005503 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 685039005504 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 685039005505 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 685039005506 nucleophilic elbow; other site 685039005507 catalytic triad; other site 685039005508 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 685039005509 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 685039005510 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 685039005511 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 685039005512 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 685039005513 HsdM N-terminal domain; Region: HsdM_N; pfam12161 685039005514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039005515 S-adenosylmethionine binding site [chemical binding]; other site 685039005516 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 685039005517 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 685039005518 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 685039005519 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 685039005520 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 685039005521 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 685039005522 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 685039005523 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 685039005524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039005525 Walker A/P-loop; other site 685039005526 ATP binding site [chemical binding]; other site 685039005527 Q-loop/lid; other site 685039005528 ABC transporter signature motif; other site 685039005529 Walker B; other site 685039005530 D-loop; other site 685039005531 H-loop/switch region; other site 685039005532 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 685039005533 active site 685039005534 catalytic triad [active] 685039005535 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 685039005536 Flavoprotein; Region: Flavoprotein; pfam02441 685039005537 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 685039005538 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 685039005539 active site 685039005540 zinc binding site [ion binding]; other site 685039005541 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 685039005542 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 685039005543 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 685039005544 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 685039005545 HTH-like domain; Region: HTH_21; pfam13276 685039005546 Integrase core domain; Region: rve; pfam00665 685039005547 Integrase core domain; Region: rve_3; cl15866 685039005548 Transposase; Region: HTH_Tnp_1; cl17663 685039005549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039005550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039005551 Helix-turn-helix domain; Region: HTH_28; pfam13518 685039005552 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 685039005553 beta-channel forming cytolysin; Region: hlyII; TIGR01002 685039005554 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 685039005555 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 685039005556 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 685039005557 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 685039005558 active site 685039005559 DNA binding site [nucleotide binding] 685039005560 Int/Topo IB signature motif; other site 685039005561 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 685039005562 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 685039005563 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 685039005564 ferrochelatase; Provisional; Region: PRK12435 685039005565 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 685039005566 C-terminal domain interface [polypeptide binding]; other site 685039005567 active site 685039005568 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 685039005569 active site 685039005570 N-terminal domain interface [polypeptide binding]; other site 685039005571 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 685039005572 substrate binding site [chemical binding]; other site 685039005573 active site 685039005574 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 685039005575 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 685039005576 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 685039005577 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685039005578 Walker A/P-loop; other site 685039005579 ATP binding site [chemical binding]; other site 685039005580 Q-loop/lid; other site 685039005581 ABC transporter signature motif; other site 685039005582 Walker B; other site 685039005583 D-loop; other site 685039005584 H-loop/switch region; other site 685039005585 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 685039005586 HIT family signature motif; other site 685039005587 catalytic residue [active] 685039005588 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 685039005589 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 685039005590 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 685039005591 SurA N-terminal domain; Region: SurA_N_3; cl07813 685039005592 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 685039005593 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 685039005594 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 685039005595 generic binding surface II; other site 685039005596 generic binding surface I; other site 685039005597 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685039005598 Zn2+ binding site [ion binding]; other site 685039005599 Mg2+ binding site [ion binding]; other site 685039005600 Uncharacterized conserved protein [Function unknown]; Region: COG4717 685039005601 P-loop containing region of AAA domain; Region: AAA_29; cl17516 685039005602 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 685039005603 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 685039005604 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 685039005605 active site 685039005606 metal binding site [ion binding]; metal-binding site 685039005607 DNA binding site [nucleotide binding] 685039005608 hypothetical protein; Provisional; Region: PRK13676 685039005609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 685039005610 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685039005611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039005612 non-specific DNA binding site [nucleotide binding]; other site 685039005613 salt bridge; other site 685039005614 sequence-specific DNA binding site [nucleotide binding]; other site 685039005615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685039005616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039005617 active site 685039005618 phosphorylation site [posttranslational modification] 685039005619 intermolecular recognition site; other site 685039005620 dimerization interface [polypeptide binding]; other site 685039005621 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685039005622 DNA binding residues [nucleotide binding] 685039005623 dimerization interface [polypeptide binding]; other site 685039005624 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 685039005625 GAF domain; Region: GAF_3; pfam13492 685039005626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 685039005627 Histidine kinase; Region: HisKA_3; pfam07730 685039005628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039005629 ATP binding site [chemical binding]; other site 685039005630 Mg2+ binding site [ion binding]; other site 685039005631 G-X-G motif; other site 685039005632 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 685039005633 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 685039005634 active site 685039005635 fumarate hydratase; Reviewed; Region: fumC; PRK00485 685039005636 Class II fumarases; Region: Fumarase_classII; cd01362 685039005637 active site 685039005638 tetramer interface [polypeptide binding]; other site 685039005639 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 685039005640 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 685039005641 active site 685039005642 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 685039005643 epoxyqueuosine reductase; Region: TIGR00276 685039005644 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 685039005645 HEAT repeats; Region: HEAT_2; pfam13646 685039005646 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 685039005647 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 685039005648 Walker A/P-loop; other site 685039005649 ATP binding site [chemical binding]; other site 685039005650 Q-loop/lid; other site 685039005651 ABC transporter signature motif; other site 685039005652 Walker B; other site 685039005653 D-loop; other site 685039005654 H-loop/switch region; other site 685039005655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685039005656 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 685039005657 substrate binding pocket [chemical binding]; other site 685039005658 membrane-bound complex binding site; other site 685039005659 hinge residues; other site 685039005660 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 685039005661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039005662 dimer interface [polypeptide binding]; other site 685039005663 conserved gate region; other site 685039005664 putative PBP binding loops; other site 685039005665 ABC-ATPase subunit interface; other site 685039005666 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 685039005667 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 685039005668 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 685039005669 metal binding site 2 [ion binding]; metal-binding site 685039005670 putative DNA binding helix; other site 685039005671 metal binding site 1 [ion binding]; metal-binding site 685039005672 dimer interface [polypeptide binding]; other site 685039005673 structural Zn2+ binding site [ion binding]; other site 685039005674 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 685039005675 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 685039005676 NAD binding site [chemical binding]; other site 685039005677 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 685039005678 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 685039005679 catalytic triad [active] 685039005680 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 685039005681 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685039005682 inhibitor-cofactor binding pocket; inhibition site 685039005683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039005684 catalytic residue [active] 685039005685 Predicted membrane protein [Function unknown]; Region: COG4129 685039005686 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 685039005687 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685039005688 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685039005689 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 685039005690 Walker A/P-loop; other site 685039005691 ATP binding site [chemical binding]; other site 685039005692 Q-loop/lid; other site 685039005693 ABC transporter signature motif; other site 685039005694 Walker B; other site 685039005695 D-loop; other site 685039005696 H-loop/switch region; other site 685039005697 hypothetical protein; Provisional; Region: PRK13662 685039005698 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 685039005699 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 685039005700 minor groove reading motif; other site 685039005701 helix-hairpin-helix signature motif; other site 685039005702 substrate binding pocket [chemical binding]; other site 685039005703 active site 685039005704 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 685039005705 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 685039005706 DNA binding and oxoG recognition site [nucleotide binding] 685039005707 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 685039005708 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 685039005709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039005710 Walker A/P-loop; other site 685039005711 ATP binding site [chemical binding]; other site 685039005712 Q-loop/lid; other site 685039005713 ABC transporter signature motif; other site 685039005714 Walker B; other site 685039005715 H-loop/switch region; other site 685039005716 RecX family; Region: RecX; cl00936 685039005717 glycosyltransferase; Provisional; Region: PRK13481 685039005718 Transglycosylase; Region: Transgly; pfam00912 685039005719 Transposase; Region: HTH_Tnp_1; cl17663 685039005720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039005721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039005722 Helix-turn-helix domain; Region: HTH_28; pfam13518 685039005723 HTH-like domain; Region: HTH_21; pfam13276 685039005724 Integrase core domain; Region: rve; pfam00665 685039005725 Integrase core domain; Region: rve_3; cl15866 685039005726 intracellular protease, PfpI family; Region: PfpI; TIGR01382 685039005727 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 685039005728 proposed catalytic triad [active] 685039005729 conserved cys residue [active] 685039005730 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 685039005731 probable integrated prophage, phiSaov3 685039005732 beta-channel forming cytolysin; Region: hlyII; TIGR01002 685039005733 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 685039005734 CHAP domain; Region: CHAP; pfam05257 685039005735 Small integral membrane protein [Function unknown]; Region: COG5546 685039005736 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 685039005737 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 685039005738 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 685039005739 Phage tail protein; Region: Sipho_tail; cl17486 685039005740 Phage tail protein; Region: Sipho_tail; cl17486 685039005741 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 685039005742 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 685039005743 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 685039005744 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 685039005745 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 685039005746 oligomerization interface [polypeptide binding]; other site 685039005747 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 685039005748 Phage capsid family; Region: Phage_capsid; pfam05065 685039005749 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 685039005750 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 685039005751 Phage-related protein [Function unknown]; Region: COG4695; cl01923 685039005752 Phage Terminase; Region: Terminase_1; pfam03354 685039005753 Phage terminase, small subunit; Region: Terminase_4; pfam05119 685039005754 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 685039005755 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685039005756 active site 685039005757 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 685039005758 putative metal binding site [ion binding]; other site 685039005759 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 685039005760 Transcriptional activator RinB; Region: RinB; pfam06116 685039005761 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 685039005762 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 685039005763 trimer interface [polypeptide binding]; other site 685039005764 active site 685039005765 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 685039005766 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 685039005767 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 685039005768 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 685039005769 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 685039005770 potential frameshift: common BLAST hit: gi|88195751|ref|YP_500560.1| bacteriophage L54a, DnaB-like helicase family protein 685039005771 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 685039005772 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 685039005773 Walker A motif; other site 685039005774 ATP binding site [chemical binding]; other site 685039005775 Walker B motif; other site 685039005776 DNA binding loops [nucleotide binding] 685039005777 phage replisome organizer, putative, N-terminal region; Region: phage_rep_org_N; TIGR01714 685039005778 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 685039005779 AP2 domain; Region: AP2; pfam00847 685039005780 DNA binding site [nucleotide binding] 685039005781 Protein of unknown function (DUF968); Region: DUF968; pfam06147 685039005782 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 685039005783 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685039005784 dimer interface [polypeptide binding]; other site 685039005785 ssDNA binding site [nucleotide binding]; other site 685039005786 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685039005787 ERF superfamily; Region: ERF; pfam04404 685039005788 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 685039005789 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 685039005790 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 685039005791 DNA-binding interface [nucleotide binding]; DNA binding site 685039005792 Prophage antirepressor [Transcription]; Region: COG3617 685039005793 BRO family, N-terminal domain; Region: Bro-N; smart01040 685039005794 ORF6C domain; Region: ORF6C; pfam10552 685039005795 Protein of unknown function (DUF739); Region: DUF739; pfam05339 685039005796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039005797 sequence-specific DNA binding site [nucleotide binding]; other site 685039005798 salt bridge; other site 685039005799 Predicted transcriptional regulator [Transcription]; Region: COG2932 685039005800 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 685039005801 Catalytic site [active] 685039005802 HIRAN domain; Region: HIRAN; pfam08797 685039005803 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 685039005804 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 685039005805 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 685039005806 Int/Topo IB signature motif; other site 685039005807 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 685039005808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685039005809 FeS/SAM binding site; other site 685039005810 YfkB-like domain; Region: YfkB; pfam08756 685039005811 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 685039005812 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 685039005813 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 685039005814 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 685039005815 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 685039005816 Low molecular weight phosphatase family; Region: LMWPc; cd00115 685039005817 active site 685039005818 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 685039005819 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685039005820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039005821 active site 685039005822 phosphorylation site [posttranslational modification] 685039005823 intermolecular recognition site; other site 685039005824 dimerization interface [polypeptide binding]; other site 685039005825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685039005826 DNA binding residues [nucleotide binding] 685039005827 dimerization interface [polypeptide binding]; other site 685039005828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 685039005829 Histidine kinase; Region: HisKA_3; pfam07730 685039005830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039005831 ATP binding site [chemical binding]; other site 685039005832 Mg2+ binding site [ion binding]; other site 685039005833 G-X-G motif; other site 685039005834 Predicted membrane protein [Function unknown]; Region: COG4758 685039005835 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 685039005836 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 685039005837 active site 685039005838 Predicted membrane protein [Function unknown]; Region: COG4129 685039005839 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 685039005840 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 685039005841 catalytic triad [active] 685039005842 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 685039005843 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685039005844 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 685039005845 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 685039005846 Ferritin-like domain; Region: Ferritin; pfam00210 685039005847 ferroxidase diiron center [ion binding]; other site 685039005848 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 685039005849 active site 685039005850 catalytic site [active] 685039005851 substrate binding site [chemical binding]; other site 685039005852 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 685039005853 active site 685039005854 DNA polymerase IV; Validated; Region: PRK02406 685039005855 DNA binding site [nucleotide binding] 685039005856 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 685039005857 TRAM domain; Region: TRAM; cl01282 685039005858 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 685039005859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039005860 S-adenosylmethionine binding site [chemical binding]; other site 685039005861 putative lipid kinase; Reviewed; Region: PRK13337 685039005862 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 685039005863 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 685039005864 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 685039005865 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 685039005866 GatB domain; Region: GatB_Yqey; pfam02637 685039005867 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 685039005868 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 685039005869 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 685039005870 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 685039005871 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 685039005872 Na binding site [ion binding]; other site 685039005873 Predicted transcriptional regulators [Transcription]; Region: COG1733 685039005874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685039005875 dimerization interface [polypeptide binding]; other site 685039005876 putative Zn2+ binding site [ion binding]; other site 685039005877 putative DNA binding site [nucleotide binding]; other site 685039005878 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 685039005879 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 685039005880 FMN binding site [chemical binding]; other site 685039005881 substrate binding site [chemical binding]; other site 685039005882 putative catalytic residue [active] 685039005883 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 685039005884 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 685039005885 putative dimer interface [polypeptide binding]; other site 685039005886 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 685039005887 putative dimer interface [polypeptide binding]; other site 685039005888 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 685039005889 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 685039005890 nucleotide binding pocket [chemical binding]; other site 685039005891 K-X-D-G motif; other site 685039005892 catalytic site [active] 685039005893 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 685039005894 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 685039005895 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 685039005896 Dimer interface [polypeptide binding]; other site 685039005897 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 685039005898 Part of AAA domain; Region: AAA_19; pfam13245 685039005899 Family description; Region: UvrD_C_2; pfam13538 685039005900 PcrB family; Region: PcrB; pfam01884 685039005901 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 685039005902 substrate binding site [chemical binding]; other site 685039005903 putative active site [active] 685039005904 dimer interface [polypeptide binding]; other site 685039005905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 685039005906 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 685039005907 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 685039005908 tetramer interface [polypeptide binding]; other site 685039005909 active site 685039005910 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 685039005911 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 685039005912 Staphostatin A; Region: Staphostatin_A; pfam09022 685039005913 NETI protein; Region: NETI; pfam14044 685039005914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 685039005915 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 685039005916 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 685039005917 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 685039005918 homodimer interface [polypeptide binding]; other site 685039005919 NAD binding pocket [chemical binding]; other site 685039005920 ATP binding pocket [chemical binding]; other site 685039005921 Mg binding site [ion binding]; other site 685039005922 active-site loop [active] 685039005923 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 685039005924 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 685039005925 active site 685039005926 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 685039005927 active site 685039005928 dimer interface [polypeptide binding]; other site 685039005929 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 685039005930 Prephenate dehydratase; Region: PDT; pfam00800 685039005931 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 685039005932 putative L-Phe binding site [chemical binding]; other site 685039005933 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 685039005934 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 685039005935 transmembrane helices; other site 685039005936 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 685039005937 Isochorismatase family; Region: Isochorismatase; pfam00857 685039005938 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 685039005939 catalytic triad [active] 685039005940 conserved cis-peptide bond; other site 685039005941 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 685039005942 DHH family; Region: DHH; pfam01368 685039005943 DHHA2 domain; Region: DHHA2; pfam02833 685039005944 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 685039005945 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 685039005946 NAD(P) binding site [chemical binding]; other site 685039005947 catalytic residues [active] 685039005948 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 685039005949 YolD-like protein; Region: YolD; pfam08863 685039005950 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 685039005951 active site 685039005952 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 685039005953 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 685039005954 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 685039005955 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 685039005956 Bacterial PH domain; Region: DUF304; cl01348 685039005957 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 685039005958 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685039005959 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685039005960 Walker A/P-loop; other site 685039005961 ATP binding site [chemical binding]; other site 685039005962 Q-loop/lid; other site 685039005963 ABC transporter signature motif; other site 685039005964 Walker B; other site 685039005965 D-loop; other site 685039005966 H-loop/switch region; other site 685039005967 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 685039005968 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685039005969 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685039005970 Walker A/P-loop; other site 685039005971 ATP binding site [chemical binding]; other site 685039005972 Q-loop/lid; other site 685039005973 ABC transporter signature motif; other site 685039005974 Walker B; other site 685039005975 D-loop; other site 685039005976 H-loop/switch region; other site 685039005977 Predicted transcriptional regulators [Transcription]; Region: COG1725 685039005978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685039005979 DNA-binding site [nucleotide binding]; DNA binding site 685039005980 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 685039005981 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685039005982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039005983 homodimer interface [polypeptide binding]; other site 685039005984 catalytic residue [active] 685039005985 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 685039005986 putative catalytic site [active] 685039005987 metal binding site A [ion binding]; metal-binding site 685039005988 phosphate binding site [ion binding]; other site 685039005989 metal binding site C [ion binding]; metal-binding site 685039005990 metal binding site B [ion binding]; metal-binding site 685039005991 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 685039005992 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 685039005993 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 685039005994 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 685039005995 metal binding site [ion binding]; metal-binding site 685039005996 dimer interface [polypeptide binding]; other site 685039005997 EamA-like transporter family; Region: EamA; pfam00892 685039005998 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 685039005999 EamA-like transporter family; Region: EamA; pfam00892 685039006000 5-aminolevulinate synthase; Validated; Region: PRK09064 685039006001 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 685039006002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685039006003 catalytic residue [active] 685039006004 Cation transport protein; Region: TrkH; cl17365 685039006005 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 685039006006 genomic island, SaPIov2 685039006007 CAAX protease self-immunity; Region: Abi; pfam02517 685039006008 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 685039006009 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 685039006010 Uncharacterized conserved protein [Function unknown]; Region: COG4983 685039006011 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 685039006012 nucleotide binding site [chemical binding]; other site 685039006013 D5 N terminal like; Region: D5_N; smart00885 685039006014 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 685039006015 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 685039006016 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 685039006017 DNA binding domain, excisionase family; Region: excise; TIGR01764 685039006018 BRO family, N-terminal domain; Region: Bro-N; smart01040 685039006019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039006020 non-specific DNA binding site [nucleotide binding]; other site 685039006021 salt bridge; other site 685039006022 sequence-specific DNA binding site [nucleotide binding]; other site 685039006023 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685039006024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685039006025 non-specific DNA binding site [nucleotide binding]; other site 685039006026 salt bridge; other site 685039006027 sequence-specific DNA binding site [nucleotide binding]; other site 685039006028 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 685039006029 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 685039006030 Int/Topo IB signature motif; other site 685039006031 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 685039006032 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 685039006033 ring oligomerisation interface [polypeptide binding]; other site 685039006034 ATP/Mg binding site [chemical binding]; other site 685039006035 stacking interactions; other site 685039006036 hinge regions; other site 685039006037 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 685039006038 oligomerisation interface [polypeptide binding]; other site 685039006039 mobile loop; other site 685039006040 roof hairpin; other site 685039006041 CAAX protease self-immunity; Region: Abi; pfam02517 685039006042 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 685039006043 dimer interface [polypeptide binding]; other site 685039006044 FMN binding site [chemical binding]; other site 685039006045 Predicted amidohydrolase [General function prediction only]; Region: COG0388 685039006046 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 685039006047 putative active site [active] 685039006048 catalytic triad [active] 685039006049 putative dimer interface [polypeptide binding]; other site 685039006050 Accessory gene regulator B; Region: AgrB; smart00793 685039006051 Staphylococcal AgrD protein; Region: AgrD; smart00794 685039006052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039006053 Mg2+ binding site [ion binding]; other site 685039006054 G-X-G motif; other site 685039006055 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 685039006056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039006057 active site 685039006058 phosphorylation site [posttranslational modification] 685039006059 intermolecular recognition site; other site 685039006060 dimerization interface [polypeptide binding]; other site 685039006061 LytTr DNA-binding domain; Region: LytTR; pfam04397 685039006062 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 685039006063 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 685039006064 putative substrate binding site [chemical binding]; other site 685039006065 putative ATP binding site [chemical binding]; other site 685039006066 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 685039006067 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 685039006068 substrate binding [chemical binding]; other site 685039006069 active site 685039006070 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 685039006071 Transcriptional regulators [Transcription]; Region: PurR; COG1609 685039006072 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685039006073 DNA binding site [nucleotide binding] 685039006074 domain linker motif; other site 685039006075 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 685039006076 dimerization interface [polypeptide binding]; other site 685039006077 ligand binding site [chemical binding]; other site 685039006078 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 685039006079 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 685039006080 CPxP motif; other site 685039006081 Predicted transporter component [General function prediction only]; Region: COG2391 685039006082 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 685039006083 Sulphur transport; Region: Sulf_transp; pfam04143 685039006084 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 685039006085 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 685039006086 CoA binding domain; Region: CoA_binding; pfam02629 685039006087 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 685039006088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685039006089 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685039006090 ABC transporter; Region: ABC_tran_2; pfam12848 685039006091 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685039006092 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 685039006093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039006094 Walker A/P-loop; other site 685039006095 ATP binding site [chemical binding]; other site 685039006096 Q-loop/lid; other site 685039006097 ABC transporter signature motif; other site 685039006098 Walker B; other site 685039006099 D-loop; other site 685039006100 H-loop/switch region; other site 685039006101 UGMP family protein; Validated; Region: PRK09604 685039006102 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 685039006103 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 685039006104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039006105 Coenzyme A binding pocket [chemical binding]; other site 685039006106 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 685039006107 Glycoprotease family; Region: Peptidase_M22; pfam00814 685039006108 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 685039006109 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 685039006110 6-phosphogluconate dehydratase; Region: edd; TIGR01196 685039006111 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 685039006112 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685039006113 PYR/PP interface [polypeptide binding]; other site 685039006114 dimer interface [polypeptide binding]; other site 685039006115 TPP binding site [chemical binding]; other site 685039006116 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685039006117 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 685039006118 TPP-binding site [chemical binding]; other site 685039006119 dimer interface [polypeptide binding]; other site 685039006120 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 685039006121 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 685039006122 ketol-acid reductoisomerase; Provisional; Region: PRK05479 685039006123 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 685039006124 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 685039006125 2-isopropylmalate synthase; Validated; Region: PRK00915 685039006126 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 685039006127 active site 685039006128 catalytic residues [active] 685039006129 metal binding site [ion binding]; metal-binding site 685039006130 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 685039006131 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 685039006132 tartrate dehydrogenase; Region: TTC; TIGR02089 685039006133 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 685039006134 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 685039006135 substrate binding site [chemical binding]; other site 685039006136 ligand binding site [chemical binding]; other site 685039006137 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 685039006138 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 685039006139 substrate binding site [chemical binding]; other site 685039006140 threonine dehydratase; Validated; Region: PRK08639 685039006141 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 685039006142 tetramer interface [polypeptide binding]; other site 685039006143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039006144 catalytic residue [active] 685039006145 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 685039006146 putative Ile/Val binding site [chemical binding]; other site 685039006147 hypothetical protein; Provisional; Region: PRK04351 685039006148 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 685039006149 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 685039006150 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 685039006151 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 685039006152 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 685039006153 RNA binding site [nucleotide binding]; other site 685039006154 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 685039006155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685039006156 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 685039006157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685039006158 DNA binding residues [nucleotide binding] 685039006159 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 685039006160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039006161 ATP binding site [chemical binding]; other site 685039006162 Mg2+ binding site [ion binding]; other site 685039006163 G-X-G motif; other site 685039006164 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 685039006165 anti sigma factor interaction site; other site 685039006166 regulatory phosphorylation site [posttranslational modification]; other site 685039006167 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 685039006168 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 685039006169 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 685039006170 PemK-like protein; Region: PemK; pfam02452 685039006171 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 685039006172 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 685039006173 active site 685039006174 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685039006175 dimer interface [polypeptide binding]; other site 685039006176 substrate binding site [chemical binding]; other site 685039006177 catalytic residues [active] 685039006178 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 685039006179 Uncharacterized conserved protein [Function unknown]; Region: COG3402 685039006180 Predicted membrane protein [Function unknown]; Region: COG3428 685039006181 Bacterial PH domain; Region: DUF304; pfam03703 685039006182 Bacterial PH domain; Region: DUF304; pfam03703 685039006183 Bacterial PH domain; Region: DUF304; cl01348 685039006184 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 685039006185 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 685039006186 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685039006187 Soluble P-type ATPase [General function prediction only]; Region: COG4087 685039006188 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 685039006189 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 685039006190 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 685039006191 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 685039006192 Ligand Binding Site [chemical binding]; other site 685039006193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685039006194 dimer interface [polypeptide binding]; other site 685039006195 phosphorylation site [posttranslational modification] 685039006196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039006197 ATP binding site [chemical binding]; other site 685039006198 Mg2+ binding site [ion binding]; other site 685039006199 G-X-G motif; other site 685039006200 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685039006201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039006202 active site 685039006203 phosphorylation site [posttranslational modification] 685039006204 intermolecular recognition site; other site 685039006205 dimerization interface [polypeptide binding]; other site 685039006206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685039006207 DNA binding site [nucleotide binding] 685039006208 DEAD-like helicases superfamily; Region: DEXDc; smart00487 685039006209 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 685039006210 ATP binding site [chemical binding]; other site 685039006211 Mg++ binding site [ion binding]; other site 685039006212 motif III; other site 685039006213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685039006214 nucleotide binding region [chemical binding]; other site 685039006215 ATP-binding site [chemical binding]; other site 685039006216 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 685039006217 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685039006218 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685039006219 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685039006220 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 685039006221 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 685039006222 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 685039006223 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 685039006224 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 685039006225 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 685039006226 putative homodimer interface [polypeptide binding]; other site 685039006227 putative homotetramer interface [polypeptide binding]; other site 685039006228 allosteric switch controlling residues; other site 685039006229 putative metal binding site [ion binding]; other site 685039006230 putative homodimer-homodimer interface [polypeptide binding]; other site 685039006231 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 685039006232 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 685039006233 putative active site [active] 685039006234 catalytic site [active] 685039006235 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 685039006236 putative active site [active] 685039006237 catalytic site [active] 685039006238 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 685039006239 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685039006240 Zn2+ binding site [ion binding]; other site 685039006241 Mg2+ binding site [ion binding]; other site 685039006242 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 685039006243 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 685039006244 thiamine phosphate binding site [chemical binding]; other site 685039006245 active site 685039006246 pyrophosphate binding site [ion binding]; other site 685039006247 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 685039006248 substrate binding site [chemical binding]; other site 685039006249 multimerization interface [polypeptide binding]; other site 685039006250 ATP binding site [chemical binding]; other site 685039006251 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 685039006252 dimer interface [polypeptide binding]; other site 685039006253 substrate binding site [chemical binding]; other site 685039006254 ATP binding site [chemical binding]; other site 685039006255 thiaminase II; Region: salvage_TenA; TIGR04306 685039006256 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 685039006257 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 685039006258 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685039006259 dimer interface [polypeptide binding]; other site 685039006260 ssDNA binding site [nucleotide binding]; other site 685039006261 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685039006262 YwpF-like protein; Region: YwpF; pfam14183 685039006263 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 685039006264 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 685039006265 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 685039006266 hinge; other site 685039006267 active site 685039006268 Predicted membrane protein [Function unknown]; Region: COG4836 685039006269 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 685039006270 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 685039006271 gamma subunit interface [polypeptide binding]; other site 685039006272 epsilon subunit interface [polypeptide binding]; other site 685039006273 LBP interface [polypeptide binding]; other site 685039006274 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 685039006275 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 685039006276 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 685039006277 alpha subunit interaction interface [polypeptide binding]; other site 685039006278 Walker A motif; other site 685039006279 ATP binding site [chemical binding]; other site 685039006280 Walker B motif; other site 685039006281 inhibitor binding site; inhibition site 685039006282 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 685039006283 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 685039006284 core domain interface [polypeptide binding]; other site 685039006285 delta subunit interface [polypeptide binding]; other site 685039006286 epsilon subunit interface [polypeptide binding]; other site 685039006287 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 685039006288 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 685039006289 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 685039006290 beta subunit interaction interface [polypeptide binding]; other site 685039006291 Walker A motif; other site 685039006292 ATP binding site [chemical binding]; other site 685039006293 Walker B motif; other site 685039006294 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 685039006295 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 685039006296 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 685039006297 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 685039006298 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 685039006299 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 685039006300 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 685039006301 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 685039006302 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 685039006303 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 685039006304 active site 685039006305 homodimer interface [polypeptide binding]; other site 685039006306 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685039006307 active site 685039006308 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 685039006309 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 685039006310 dimer interface [polypeptide binding]; other site 685039006311 active site 685039006312 glycine-pyridoxal phosphate binding site [chemical binding]; other site 685039006313 folate binding site [chemical binding]; other site 685039006314 hypothetical protein; Provisional; Region: PRK13690 685039006315 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 685039006316 Low molecular weight phosphatase family; Region: LMWPc; cd00115 685039006317 active site 685039006318 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 685039006319 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 685039006320 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 685039006321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039006322 S-adenosylmethionine binding site [chemical binding]; other site 685039006323 peptide chain release factor 1; Validated; Region: prfA; PRK00591 685039006324 This domain is found in peptide chain release factors; Region: PCRF; smart00937 685039006325 RF-1 domain; Region: RF-1; pfam00472 685039006326 thymidine kinase; Provisional; Region: PRK04296 685039006327 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 685039006328 transcription termination factor Rho; Provisional; Region: rho; PRK09376 685039006329 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 685039006330 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 685039006331 RNA binding site [nucleotide binding]; other site 685039006332 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 685039006333 multimer interface [polypeptide binding]; other site 685039006334 Walker A motif; other site 685039006335 ATP binding site [chemical binding]; other site 685039006336 Walker B motif; other site 685039006337 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 685039006338 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 685039006339 NAD binding site [chemical binding]; other site 685039006340 catalytic residues [active] 685039006341 Predicted transcriptional regulators [Transcription]; Region: COG1733 685039006342 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 685039006343 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 685039006344 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 685039006345 hinge; other site 685039006346 active site 685039006347 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 685039006348 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 685039006349 intersubunit interface [polypeptide binding]; other site 685039006350 active site 685039006351 zinc binding site [ion binding]; other site 685039006352 Na+ binding site [ion binding]; other site 685039006353 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 685039006354 CTP synthetase; Validated; Region: pyrG; PRK05380 685039006355 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 685039006356 Catalytic site [active] 685039006357 active site 685039006358 UTP binding site [chemical binding]; other site 685039006359 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 685039006360 active site 685039006361 putative oxyanion hole; other site 685039006362 catalytic triad [active] 685039006363 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 685039006364 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 685039006365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039006366 Coenzyme A binding pocket [chemical binding]; other site 685039006367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 685039006368 Coenzyme A binding pocket [chemical binding]; other site 685039006369 pantothenate kinase; Provisional; Region: PRK13317 685039006370 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 685039006371 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 685039006372 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 685039006373 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 685039006374 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 685039006375 metal binding site [ion binding]; metal-binding site 685039006376 S-ribosylhomocysteinase; Provisional; Region: PRK02260 685039006377 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 685039006378 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 685039006379 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 685039006380 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 685039006381 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 685039006382 intersubunit interface [polypeptide binding]; other site 685039006383 active site 685039006384 catalytic residue [active] 685039006385 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 685039006386 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 685039006387 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 685039006388 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 685039006389 dimerization interface [polypeptide binding]; other site 685039006390 DPS ferroxidase diiron center [ion binding]; other site 685039006391 ion pore; other site 685039006392 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 685039006393 EVE domain; Region: EVE; cl00728 685039006394 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 685039006395 NADH(P)-binding; Region: NAD_binding_10; pfam13460 685039006396 NAD(P) binding site [chemical binding]; other site 685039006397 putative active site [active] 685039006398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685039006399 dimerization interface [polypeptide binding]; other site 685039006400 putative DNA binding site [nucleotide binding]; other site 685039006401 putative Zn2+ binding site [ion binding]; other site 685039006402 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 685039006403 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 685039006404 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 685039006405 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 685039006406 catalytic residues [active] 685039006407 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 685039006408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039006409 active site 685039006410 motif I; other site 685039006411 motif II; other site 685039006412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039006413 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 685039006414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039006415 Walker A/P-loop; other site 685039006416 ATP binding site [chemical binding]; other site 685039006417 Q-loop/lid; other site 685039006418 ABC transporter signature motif; other site 685039006419 Walker B; other site 685039006420 D-loop; other site 685039006421 H-loop/switch region; other site 685039006422 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 685039006423 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 685039006424 glutaminase active site [active] 685039006425 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 685039006426 dimer interface [polypeptide binding]; other site 685039006427 active site 685039006428 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 685039006429 dimer interface [polypeptide binding]; other site 685039006430 active site 685039006431 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 685039006432 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 685039006433 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 685039006434 active site 685039006435 P-loop; other site 685039006436 phosphorylation site [posttranslational modification] 685039006437 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 685039006438 HTH domain; Region: HTH_11; pfam08279 685039006439 Mga helix-turn-helix domain; Region: Mga; pfam05043 685039006440 PRD domain; Region: PRD; pfam00874 685039006441 PRD domain; Region: PRD; pfam00874 685039006442 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 685039006443 active site 685039006444 P-loop; other site 685039006445 phosphorylation site [posttranslational modification] 685039006446 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 685039006447 active site 685039006448 phosphorylation site [posttranslational modification] 685039006449 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685039006450 active site 685039006451 phosphorylation site [posttranslational modification] 685039006452 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 685039006453 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 685039006454 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 685039006455 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 685039006456 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 685039006457 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039006458 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039006459 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039006460 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039006461 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039006462 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 685039006463 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 685039006464 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 685039006465 active site 685039006466 substrate binding site [chemical binding]; other site 685039006467 metal binding site [ion binding]; metal-binding site 685039006468 TIGR00159 family protein; Region: TIGR00159 685039006469 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 685039006470 Arginase family; Region: Arginase; cd09989 685039006471 active site 685039006472 Mn binding site [ion binding]; other site 685039006473 oligomer interface [polypeptide binding]; other site 685039006474 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 685039006475 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 685039006476 Walker A motif; other site 685039006477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039006478 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039006479 putative substrate translocation pore; other site 685039006480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039006481 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039006482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039006483 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 685039006484 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 685039006485 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 685039006486 substrate binding site; other site 685039006487 dimerization interface; other site 685039006488 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 685039006489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 685039006490 Nucleoside recognition; Region: Gate; pfam07670 685039006491 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685039006492 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039006493 ABC-ATPase subunit interface; other site 685039006494 dimer interface [polypeptide binding]; other site 685039006495 putative PBP binding regions; other site 685039006496 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 685039006497 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685039006498 ABC-ATPase subunit interface; other site 685039006499 dimer interface [polypeptide binding]; other site 685039006500 putative PBP binding regions; other site 685039006501 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 685039006502 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685039006503 siderophore binding site; other site 685039006504 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 685039006505 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 685039006506 dimer interface [polypeptide binding]; other site 685039006507 active site 685039006508 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685039006509 substrate binding site [chemical binding]; other site 685039006510 catalytic residue [active] 685039006511 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 685039006512 IucA / IucC family; Region: IucA_IucC; pfam04183 685039006513 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 685039006514 H+ Antiporter protein; Region: 2A0121; TIGR00900 685039006515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039006516 putative substrate translocation pore; other site 685039006517 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 685039006518 IucA / IucC family; Region: IucA_IucC; pfam04183 685039006519 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 685039006520 Asp23 family; Region: Asp23; pfam03780 685039006521 Small integral membrane protein [Function unknown]; Region: COG5547 685039006522 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 685039006523 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 685039006524 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 685039006525 putative NAD(P) binding site [chemical binding]; other site 685039006526 dimer interface [polypeptide binding]; other site 685039006527 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 685039006528 Prostaglandin dehydrogenases; Region: PGDH; cd05288 685039006529 NAD(P) binding site [chemical binding]; other site 685039006530 substrate binding site [chemical binding]; other site 685039006531 dimer interface [polypeptide binding]; other site 685039006532 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 685039006533 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 685039006534 beta-galactosidase; Region: BGL; TIGR03356 685039006535 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 685039006536 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 685039006537 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 685039006538 active site 685039006539 P-loop; other site 685039006540 phosphorylation site [posttranslational modification] 685039006541 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 685039006542 methionine cluster; other site 685039006543 active site 685039006544 phosphorylation site [posttranslational modification] 685039006545 metal binding site [ion binding]; metal-binding site 685039006546 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 685039006547 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 685039006548 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 685039006549 putative substrate binding site [chemical binding]; other site 685039006550 putative ATP binding site [chemical binding]; other site 685039006551 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 685039006552 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 685039006553 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 685039006554 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 685039006555 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 685039006556 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 685039006557 NAD-dependent deacetylase; Provisional; Region: PRK00481 685039006558 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685039006559 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685039006560 active site 685039006561 catalytic tetrad [active] 685039006562 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 685039006563 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 685039006564 DNA binding residues [nucleotide binding] 685039006565 putative dimer interface [polypeptide binding]; other site 685039006566 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 685039006567 substrate binding site [chemical binding]; other site 685039006568 catalytic residues [active] 685039006569 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 685039006570 Peptidase family M23; Region: Peptidase_M23; pfam01551 685039006571 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 685039006572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 685039006573 active site 685039006574 motif I; other site 685039006575 motif II; other site 685039006576 MAP domain; Region: MAP; pfam03642 685039006577 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 685039006578 acetolactate synthase; Reviewed; Region: PRK08617 685039006579 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685039006580 PYR/PP interface [polypeptide binding]; other site 685039006581 dimer interface [polypeptide binding]; other site 685039006582 TPP binding site [chemical binding]; other site 685039006583 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685039006584 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 685039006585 TPP-binding site [chemical binding]; other site 685039006586 Transcriptional regulator; Region: Rrf2; cl17282 685039006587 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 685039006588 Divergent AAA domain; Region: AAA_4; pfam04326 685039006589 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 685039006590 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685039006591 putative DNA binding site [nucleotide binding]; other site 685039006592 putative Zn2+ binding site [ion binding]; other site 685039006593 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 685039006594 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 685039006595 23S rRNA interface [nucleotide binding]; other site 685039006596 L3 interface [polypeptide binding]; other site 685039006597 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 685039006598 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 685039006599 dimerization interface 3.5A [polypeptide binding]; other site 685039006600 active site 685039006601 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 685039006602 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 685039006603 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 685039006604 Walker A/P-loop; other site 685039006605 ATP binding site [chemical binding]; other site 685039006606 Q-loop/lid; other site 685039006607 ABC transporter signature motif; other site 685039006608 Walker B; other site 685039006609 D-loop; other site 685039006610 H-loop/switch region; other site 685039006611 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 685039006612 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 685039006613 Walker A/P-loop; other site 685039006614 ATP binding site [chemical binding]; other site 685039006615 Q-loop/lid; other site 685039006616 ABC transporter signature motif; other site 685039006617 Walker B; other site 685039006618 D-loop; other site 685039006619 H-loop/switch region; other site 685039006620 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 685039006621 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 685039006622 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 685039006623 alphaNTD homodimer interface [polypeptide binding]; other site 685039006624 alphaNTD - beta interaction site [polypeptide binding]; other site 685039006625 alphaNTD - beta' interaction site [polypeptide binding]; other site 685039006626 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 685039006627 30S ribosomal protein S11; Validated; Region: PRK05309 685039006628 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 685039006629 30S ribosomal protein S13; Region: bact_S13; TIGR03631 685039006630 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 685039006631 rRNA binding site [nucleotide binding]; other site 685039006632 predicted 30S ribosome binding site; other site 685039006633 adenylate kinase; Reviewed; Region: adk; PRK00279 685039006634 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 685039006635 AMP-binding site [chemical binding]; other site 685039006636 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 685039006637 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 685039006638 SecY translocase; Region: SecY; pfam00344 685039006639 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 685039006640 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 685039006641 23S rRNA binding site [nucleotide binding]; other site 685039006642 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 685039006643 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 685039006644 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 685039006645 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 685039006646 5S rRNA interface [nucleotide binding]; other site 685039006647 L27 interface [polypeptide binding]; other site 685039006648 23S rRNA interface [nucleotide binding]; other site 685039006649 L5 interface [polypeptide binding]; other site 685039006650 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 685039006651 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 685039006652 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 685039006653 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 685039006654 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 685039006655 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 685039006656 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 685039006657 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 685039006658 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 685039006659 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 685039006660 RNA binding site [nucleotide binding]; other site 685039006661 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 685039006662 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 685039006663 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 685039006664 23S rRNA interface [nucleotide binding]; other site 685039006665 putative translocon interaction site; other site 685039006666 signal recognition particle (SRP54) interaction site; other site 685039006667 L23 interface [polypeptide binding]; other site 685039006668 trigger factor interaction site; other site 685039006669 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 685039006670 23S rRNA interface [nucleotide binding]; other site 685039006671 5S rRNA interface [nucleotide binding]; other site 685039006672 putative antibiotic binding site [chemical binding]; other site 685039006673 L25 interface [polypeptide binding]; other site 685039006674 L27 interface [polypeptide binding]; other site 685039006675 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 685039006676 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 685039006677 G-X-X-G motif; other site 685039006678 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 685039006679 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 685039006680 putative translocon binding site; other site 685039006681 protein-rRNA interface [nucleotide binding]; other site 685039006682 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 685039006683 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 685039006684 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 685039006685 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 685039006686 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 685039006687 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 685039006688 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 685039006689 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 685039006690 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 685039006691 DNA topoisomerase III; Provisional; Region: PRK07726 685039006692 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 685039006693 active site 685039006694 putative interdomain interaction site [polypeptide binding]; other site 685039006695 putative metal-binding site [ion binding]; other site 685039006696 putative nucleotide binding site [chemical binding]; other site 685039006697 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 685039006698 domain I; other site 685039006699 DNA binding groove [nucleotide binding] 685039006700 phosphate binding site [ion binding]; other site 685039006701 domain II; other site 685039006702 domain III; other site 685039006703 nucleotide binding site [chemical binding]; other site 685039006704 catalytic site [active] 685039006705 domain IV; other site 685039006706 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 685039006707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039006708 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 685039006709 Coenzyme A binding pocket [chemical binding]; other site 685039006710 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 685039006711 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 685039006712 Predicted permeases [General function prediction only]; Region: COG0679 685039006713 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 685039006714 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 685039006715 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 685039006716 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 685039006717 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 685039006718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039006719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039006720 putative substrate translocation pore; other site 685039006721 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 685039006722 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685039006723 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 685039006724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685039006725 FeS/SAM binding site; other site 685039006726 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 685039006727 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 685039006728 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 685039006729 GTP binding site; other site 685039006730 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 685039006731 MoaE interaction surface [polypeptide binding]; other site 685039006732 MoeB interaction surface [polypeptide binding]; other site 685039006733 thiocarboxylated glycine; other site 685039006734 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 685039006735 MoaE homodimer interface [polypeptide binding]; other site 685039006736 MoaD interaction [polypeptide binding]; other site 685039006737 active site residues [active] 685039006738 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 685039006739 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 685039006740 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 685039006741 dimer interface [polypeptide binding]; other site 685039006742 putative functional site; other site 685039006743 putative MPT binding site; other site 685039006744 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 685039006745 trimer interface [polypeptide binding]; other site 685039006746 dimer interface [polypeptide binding]; other site 685039006747 putative active site [active] 685039006748 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 685039006749 MPT binding site; other site 685039006750 trimer interface [polypeptide binding]; other site 685039006751 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 685039006752 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 685039006753 ATP binding site [chemical binding]; other site 685039006754 substrate interface [chemical binding]; other site 685039006755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039006756 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 685039006757 Walker A/P-loop; other site 685039006758 ATP binding site [chemical binding]; other site 685039006759 Q-loop/lid; other site 685039006760 ABC transporter signature motif; other site 685039006761 Walker B; other site 685039006762 D-loop; other site 685039006763 H-loop/switch region; other site 685039006764 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 685039006765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039006766 dimer interface [polypeptide binding]; other site 685039006767 conserved gate region; other site 685039006768 putative PBP binding loops; other site 685039006769 ABC-ATPase subunit interface; other site 685039006770 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 685039006771 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685039006772 substrate binding pocket [chemical binding]; other site 685039006773 membrane-bound complex binding site; other site 685039006774 hinge residues; other site 685039006775 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 685039006776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039006777 Coenzyme A binding pocket [chemical binding]; other site 685039006778 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 685039006779 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 685039006780 active site 685039006781 dimerization interface [polypeptide binding]; other site 685039006782 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685039006783 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685039006784 intersubunit interface [polypeptide binding]; other site 685039006785 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685039006786 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685039006787 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 685039006788 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 685039006789 alpha-gamma subunit interface [polypeptide binding]; other site 685039006790 beta-gamma subunit interface [polypeptide binding]; other site 685039006791 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 685039006792 gamma-beta subunit interface [polypeptide binding]; other site 685039006793 alpha-beta subunit interface [polypeptide binding]; other site 685039006794 urease subunit alpha; Reviewed; Region: ureC; PRK13207 685039006795 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 685039006796 subunit interactions [polypeptide binding]; other site 685039006797 active site 685039006798 flap region; other site 685039006799 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 685039006800 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 685039006801 dimer interface [polypeptide binding]; other site 685039006802 catalytic residues [active] 685039006803 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 685039006804 UreF; Region: UreF; pfam01730 685039006805 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685039006806 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 685039006807 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 685039006808 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 685039006809 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 685039006810 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685039006811 Helix-turn-helix domain; Region: HTH_18; pfam12833 685039006812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685039006813 Surface antigen [General function prediction only]; Region: COG3942 685039006814 CHAP domain; Region: CHAP; pfam05257 685039006815 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 685039006816 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 685039006817 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 685039006818 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 685039006819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 685039006820 Surface antigen [General function prediction only]; Region: COG3942 685039006821 CHAP domain; Region: CHAP; pfam05257 685039006822 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 685039006823 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 685039006824 putative ligand binding site [chemical binding]; other site 685039006825 putative NAD binding site [chemical binding]; other site 685039006826 catalytic site [active] 685039006827 hypothetical protein; Provisional; Region: PRK06753 685039006828 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 685039006829 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 685039006830 Lysozyme subfamily 2; Region: LYZ2; smart00047 685039006831 Uncharacterized conserved protein [Function unknown]; Region: COG2427 685039006832 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 685039006833 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 685039006834 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 685039006835 4Fe-4S binding domain; Region: Fer4; pfam00037 685039006836 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 685039006837 [4Fe-4S] binding site [ion binding]; other site 685039006838 molybdopterin cofactor binding site; other site 685039006839 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 685039006840 molybdopterin cofactor binding site; other site 685039006841 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 685039006842 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 685039006843 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 685039006844 active site 685039006845 Predicted transcriptional regulator [Transcription]; Region: COG2378 685039006846 HTH domain; Region: HTH_11; pfam08279 685039006847 CAAX protease self-immunity; Region: Abi; pfam02517 685039006848 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 685039006849 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 685039006850 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 685039006851 putative active site [active] 685039006852 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 685039006853 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 685039006854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039006855 active site 685039006856 motif I; other site 685039006857 motif II; other site 685039006858 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 685039006859 Sodium Bile acid symporter family; Region: SBF; pfam01758 685039006860 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 685039006861 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 685039006862 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 685039006863 putative active site [active] 685039006864 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 685039006865 putative hydrophobic ligand binding site [chemical binding]; other site 685039006866 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 685039006867 oxidoreductase; Provisional; Region: PRK07985 685039006868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685039006869 NAD(P) binding site [chemical binding]; other site 685039006870 active site 685039006871 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 685039006872 amidohydrolase; Region: amidohydrolases; TIGR01891 685039006873 metal binding site [ion binding]; metal-binding site 685039006874 dimer interface [polypeptide binding]; other site 685039006875 imidazolonepropionase; Validated; Region: PRK09356 685039006876 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 685039006877 active site 685039006878 urocanate hydratase; Provisional; Region: PRK05414 685039006879 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685039006880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685039006881 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 685039006882 dimerization interface [polypeptide binding]; other site 685039006883 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 685039006884 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 685039006885 active site 685039006886 metal binding site [ion binding]; metal-binding site 685039006887 formimidoylglutamase; Provisional; Region: PRK13775 685039006888 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 685039006889 putative active site [active] 685039006890 putative metal binding site [ion binding]; other site 685039006891 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 685039006892 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 685039006893 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685039006894 active site 685039006895 dimer interface [polypeptide binding]; other site 685039006896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 685039006897 MOSC domain; Region: MOSC; pfam03473 685039006898 3-alpha domain; Region: 3-alpha; pfam03475 685039006899 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 685039006900 active site 685039006901 catalytic residues [active] 685039006902 Uncharacterized conserved protein [Function unknown]; Region: COG1742 685039006903 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 685039006904 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 685039006905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039006906 Walker A/P-loop; other site 685039006907 ATP binding site [chemical binding]; other site 685039006908 Q-loop/lid; other site 685039006909 ABC transporter signature motif; other site 685039006910 Walker B; other site 685039006911 D-loop; other site 685039006912 H-loop/switch region; other site 685039006913 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 685039006914 Predicted membrane protein [Function unknown]; Region: COG3152 685039006915 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 685039006916 active site 685039006917 DNA binding site [nucleotide binding] 685039006918 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 685039006919 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 685039006920 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 685039006921 homotetramer interface [polypeptide binding]; other site 685039006922 FMN binding site [chemical binding]; other site 685039006923 homodimer contacts [polypeptide binding]; other site 685039006924 putative active site [active] 685039006925 putative substrate binding site [chemical binding]; other site 685039006926 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 685039006927 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 685039006928 oligomer interface [polypeptide binding]; other site 685039006929 metal binding site [ion binding]; metal-binding site 685039006930 metal binding site [ion binding]; metal-binding site 685039006931 putative Cl binding site [ion binding]; other site 685039006932 aspartate ring; other site 685039006933 basic sphincter; other site 685039006934 hydrophobic gate; other site 685039006935 periplasmic entrance; other site 685039006936 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 685039006937 active site 685039006938 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 685039006939 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 685039006940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039006941 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685039006942 putative substrate translocation pore; other site 685039006943 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 685039006944 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 685039006945 lipoyl-biotinyl attachment site [posttranslational modification]; other site 685039006946 HlyD family secretion protein; Region: HlyD_3; pfam13437 685039006947 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 685039006948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039006949 putative substrate translocation pore; other site 685039006950 Predicted membrane protein [Function unknown]; Region: COG4640 685039006951 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 685039006952 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685039006953 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685039006954 putative Zn2+ binding site [ion binding]; other site 685039006955 putative DNA binding site [nucleotide binding]; other site 685039006956 Uncharacterized conserved protein [Function unknown]; Region: COG1434 685039006957 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 685039006958 putative active site [active] 685039006959 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685039006960 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685039006961 Walker A/P-loop; other site 685039006962 ATP binding site [chemical binding]; other site 685039006963 Q-loop/lid; other site 685039006964 ABC transporter signature motif; other site 685039006965 Walker B; other site 685039006966 D-loop; other site 685039006967 H-loop/switch region; other site 685039006968 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685039006969 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 685039006970 FtsX-like permease family; Region: FtsX; pfam02687 685039006971 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685039006972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039006973 active site 685039006974 phosphorylation site [posttranslational modification] 685039006975 intermolecular recognition site; other site 685039006976 dimerization interface [polypeptide binding]; other site 685039006977 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685039006978 DNA binding site [nucleotide binding] 685039006979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685039006980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685039006981 dimerization interface [polypeptide binding]; other site 685039006982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685039006983 dimer interface [polypeptide binding]; other site 685039006984 phosphorylation site [posttranslational modification] 685039006985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039006986 ATP binding site [chemical binding]; other site 685039006987 Mg2+ binding site [ion binding]; other site 685039006988 G-X-G motif; other site 685039006989 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 685039006990 LytTr DNA-binding domain; Region: LytTR; smart00850 685039006991 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 685039006992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685039006993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685039006994 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 685039006995 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 685039006996 Walker A/P-loop; other site 685039006997 ATP binding site [chemical binding]; other site 685039006998 Q-loop/lid; other site 685039006999 ABC transporter signature motif; other site 685039007000 Walker B; other site 685039007001 D-loop; other site 685039007002 H-loop/switch region; other site 685039007003 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685039007004 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 685039007005 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 685039007006 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 685039007007 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 685039007008 L-lactate permease; Region: Lactate_perm; cl00701 685039007009 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 685039007010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039007011 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 685039007012 Coenzyme A binding pocket [chemical binding]; other site 685039007013 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685039007014 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 685039007015 NAD(P) binding site [chemical binding]; other site 685039007016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039007017 Coenzyme A binding pocket [chemical binding]; other site 685039007018 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 685039007019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685039007020 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039007021 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 685039007022 Predicted membrane protein [Function unknown]; Region: COG1511 685039007023 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 685039007024 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 685039007025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685039007026 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 685039007027 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 685039007028 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 685039007029 Cl binding site [ion binding]; other site 685039007030 oligomer interface [polypeptide binding]; other site 685039007031 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 685039007032 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685039007033 active site turn [active] 685039007034 phosphorylation site [posttranslational modification] 685039007035 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685039007036 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 685039007037 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685039007038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685039007039 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 685039007040 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 685039007041 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 685039007042 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 685039007043 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 685039007044 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685039007045 MarR family; Region: MarR_2; pfam12802 685039007046 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 685039007047 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 685039007048 putative dimer interface [polypeptide binding]; other site 685039007049 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 685039007050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039007051 putative substrate translocation pore; other site 685039007052 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 685039007053 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 685039007054 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685039007055 DNA binding residues [nucleotide binding] 685039007056 dimer interface [polypeptide binding]; other site 685039007057 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 685039007058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685039007059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039007060 active site 685039007061 phosphorylation site [posttranslational modification] 685039007062 intermolecular recognition site; other site 685039007063 dimerization interface [polypeptide binding]; other site 685039007064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685039007065 DNA binding residues [nucleotide binding] 685039007066 dimerization interface [polypeptide binding]; other site 685039007067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 685039007068 Histidine kinase; Region: HisKA_3; pfam07730 685039007069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039007070 ATP binding site [chemical binding]; other site 685039007071 Mg2+ binding site [ion binding]; other site 685039007072 G-X-G motif; other site 685039007073 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 685039007074 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 685039007075 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 685039007076 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 685039007077 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 685039007078 [4Fe-4S] binding site [ion binding]; other site 685039007079 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685039007080 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685039007081 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685039007082 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 685039007083 molybdopterin cofactor binding site; other site 685039007084 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 685039007085 active site 685039007086 SAM binding site [chemical binding]; other site 685039007087 homodimer interface [polypeptide binding]; other site 685039007088 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 685039007089 [2Fe-2S] cluster binding site [ion binding]; other site 685039007090 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 685039007091 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685039007092 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685039007093 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 685039007094 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 685039007095 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 685039007096 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 685039007097 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 685039007098 putative active site [active] 685039007099 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 685039007100 active site 685039007101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 685039007102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039007103 Coenzyme A binding pocket [chemical binding]; other site 685039007104 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 685039007105 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 685039007106 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 685039007107 putative hydrophobic ligand binding site [chemical binding]; other site 685039007108 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 685039007109 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685039007110 intersubunit interface [polypeptide binding]; other site 685039007111 YodA lipocalin-like domain; Region: YodA; pfam09223 685039007112 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 685039007113 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 685039007114 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 685039007115 Thioredoxin; Region: Thioredoxin_4; cl17273 685039007116 FemAB family; Region: FemAB; pfam02388 685039007117 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 685039007118 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 685039007119 Walker A/P-loop; other site 685039007120 ATP binding site [chemical binding]; other site 685039007121 Q-loop/lid; other site 685039007122 ABC transporter signature motif; other site 685039007123 Walker B; other site 685039007124 D-loop; other site 685039007125 H-loop/switch region; other site 685039007126 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 685039007127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039007128 dimer interface [polypeptide binding]; other site 685039007129 conserved gate region; other site 685039007130 putative PBP binding loops; other site 685039007131 ABC-ATPase subunit interface; other site 685039007132 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 685039007133 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685039007134 substrate binding pocket [chemical binding]; other site 685039007135 membrane-bound complex binding site; other site 685039007136 hinge residues; other site 685039007137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039007138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039007139 putative substrate translocation pore; other site 685039007140 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685039007141 catalytic core [active] 685039007142 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685039007143 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 685039007144 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 685039007145 B domain; Region: B; pfam02216 685039007146 B domain; Region: B; pfam02216 685039007147 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 685039007148 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 685039007149 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 685039007150 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 685039007151 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 685039007152 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 685039007153 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 685039007154 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 685039007155 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685039007156 catalytic residue [active] 685039007157 biotin synthase; Validated; Region: PRK06256 685039007158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685039007159 FeS/SAM binding site; other site 685039007160 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 685039007161 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685039007162 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 685039007163 inhibitor-cofactor binding pocket; inhibition site 685039007164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039007165 catalytic residue [active] 685039007166 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 685039007167 AAA domain; Region: AAA_26; pfam13500 685039007168 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 685039007169 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 685039007170 Walker A/P-loop; other site 685039007171 ATP binding site [chemical binding]; other site 685039007172 Q-loop/lid; other site 685039007173 ABC transporter signature motif; other site 685039007174 Walker B; other site 685039007175 D-loop; other site 685039007176 H-loop/switch region; other site 685039007177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685039007178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685039007179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039007180 Walker A/P-loop; other site 685039007181 ATP binding site [chemical binding]; other site 685039007182 Q-loop/lid; other site 685039007183 ABC transporter signature motif; other site 685039007184 Walker B; other site 685039007185 D-loop; other site 685039007186 H-loop/switch region; other site 685039007187 Predicted membrane protein [Function unknown]; Region: COG2246 685039007188 GtrA-like protein; Region: GtrA; pfam04138 685039007189 glycerate kinase; Region: TIGR00045 685039007190 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 685039007191 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 685039007192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039007193 putative substrate translocation pore; other site 685039007194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 685039007195 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 685039007196 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 685039007197 putative phosphoesterase; Region: acc_ester; TIGR03729 685039007198 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 685039007199 Spore germination protein; Region: Spore_permease; cl17796 685039007200 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 685039007201 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 685039007202 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685039007203 Beta-lactamase; Region: Beta-lactamase; pfam00144 685039007204 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685039007205 extended (e) SDRs; Region: SDR_e; cd08946 685039007206 NAD(P) binding site [chemical binding]; other site 685039007207 active site 685039007208 substrate binding site [chemical binding]; other site 685039007209 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 685039007210 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 685039007211 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 685039007212 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039007213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039007214 putative substrate translocation pore; other site 685039007215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039007216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039007217 dimer interface [polypeptide binding]; other site 685039007218 conserved gate region; other site 685039007219 ABC-ATPase subunit interface; other site 685039007220 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 685039007221 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 685039007222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039007223 dimer interface [polypeptide binding]; other site 685039007224 conserved gate region; other site 685039007225 putative PBP binding loops; other site 685039007226 ABC-ATPase subunit interface; other site 685039007227 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 685039007228 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 685039007229 Walker A/P-loop; other site 685039007230 ATP binding site [chemical binding]; other site 685039007231 Q-loop/lid; other site 685039007232 ABC transporter signature motif; other site 685039007233 Walker B; other site 685039007234 D-loop; other site 685039007235 H-loop/switch region; other site 685039007236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 685039007237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 685039007238 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 685039007239 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 685039007240 amino acid transporter; Region: 2A0306; TIGR00909 685039007241 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 685039007242 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 685039007243 substrate binding pocket [chemical binding]; other site 685039007244 catalytic triad [active] 685039007245 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685039007246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039007247 putative substrate translocation pore; other site 685039007248 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 685039007249 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 685039007250 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 685039007251 Walker A/P-loop; other site 685039007252 ATP binding site [chemical binding]; other site 685039007253 Q-loop/lid; other site 685039007254 ABC transporter signature motif; other site 685039007255 Walker B; other site 685039007256 D-loop; other site 685039007257 H-loop/switch region; other site 685039007258 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 685039007259 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 685039007260 oligomer interface [polypeptide binding]; other site 685039007261 active site 685039007262 metal binding site [ion binding]; metal-binding site 685039007263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 685039007264 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 685039007265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 685039007266 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 685039007267 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 685039007268 active site 685039007269 FMN binding site [chemical binding]; other site 685039007270 substrate binding site [chemical binding]; other site 685039007271 3Fe-4S cluster binding site [ion binding]; other site 685039007272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039007273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039007274 putative substrate translocation pore; other site 685039007275 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 685039007276 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685039007277 Walker A/P-loop; other site 685039007278 ATP binding site [chemical binding]; other site 685039007279 Q-loop/lid; other site 685039007280 ABC transporter signature motif; other site 685039007281 Walker B; other site 685039007282 D-loop; other site 685039007283 H-loop/switch region; other site 685039007284 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685039007285 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 685039007286 Walker A/P-loop; other site 685039007287 ATP binding site [chemical binding]; other site 685039007288 Q-loop/lid; other site 685039007289 ABC transporter signature motif; other site 685039007290 Walker B; other site 685039007291 D-loop; other site 685039007292 H-loop/switch region; other site 685039007293 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685039007294 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 685039007295 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 685039007296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039007297 dimer interface [polypeptide binding]; other site 685039007298 conserved gate region; other site 685039007299 ABC-ATPase subunit interface; other site 685039007300 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685039007301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685039007302 dimer interface [polypeptide binding]; other site 685039007303 conserved gate region; other site 685039007304 putative PBP binding loops; other site 685039007305 ABC-ATPase subunit interface; other site 685039007306 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685039007307 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 685039007308 substrate binding site [chemical binding]; other site 685039007309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 685039007310 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 685039007311 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685039007312 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 685039007313 short chain dehydrogenase; Validated; Region: PRK08589 685039007314 classical (c) SDRs; Region: SDR_c; cd05233 685039007315 NAD(P) binding site [chemical binding]; other site 685039007316 active site 685039007317 AbgT putative transporter family; Region: ABG_transport; pfam03806 685039007318 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 685039007319 Uncharacterized conserved protein [Function unknown]; Region: COG2128 685039007320 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 685039007321 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 685039007322 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 685039007323 classical (c) SDRs; Region: SDR_c; cd05233 685039007324 NAD(P) binding site [chemical binding]; other site 685039007325 active site 685039007326 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 685039007327 Protein of unknown function, DUF576; Region: DUF576; pfam04507 685039007328 Protein of unknown function, DUF576; Region: DUF576; pfam04507 685039007329 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 685039007330 PLD-like domain; Region: PLDc_2; pfam13091 685039007331 putative homodimer interface [polypeptide binding]; other site 685039007332 putative active site [active] 685039007333 catalytic site [active] 685039007334 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 685039007335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685039007336 ATP binding site [chemical binding]; other site 685039007337 putative Mg++ binding site [ion binding]; other site 685039007338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685039007339 nucleotide binding region [chemical binding]; other site 685039007340 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 685039007341 ATP-binding site [chemical binding]; other site 685039007342 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 685039007343 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 685039007344 active site 685039007345 8-oxo-dGMP binding site [chemical binding]; other site 685039007346 nudix motif; other site 685039007347 metal binding site [ion binding]; metal-binding site 685039007348 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 685039007349 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 685039007350 active site 685039007351 substrate binding site [chemical binding]; other site 685039007352 metal binding site [ion binding]; metal-binding site 685039007353 H+ Antiporter protein; Region: 2A0121; TIGR00900 685039007354 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 685039007355 tetramer interface; other site 685039007356 active site 685039007357 Transposase; Region: HTH_Tnp_1; cl17663 685039007358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039007359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039007360 Helix-turn-helix domain; Region: HTH_28; pfam13518 685039007361 HTH-like domain; Region: HTH_21; pfam13276 685039007362 Integrase core domain; Region: rve; pfam00665 685039007363 Integrase core domain; Region: rve_3; cl15866 685039007364 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 685039007365 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 685039007366 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 685039007367 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 685039007368 GntP family permease; Region: GntP_permease; pfam02447 685039007369 fructuronate transporter; Provisional; Region: PRK10034; cl15264 685039007370 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 685039007371 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 685039007372 N- and C-terminal domain interface [polypeptide binding]; other site 685039007373 active site 685039007374 catalytic site [active] 685039007375 metal binding site [ion binding]; metal-binding site 685039007376 carbohydrate binding site [chemical binding]; other site 685039007377 ATP binding site [chemical binding]; other site 685039007378 Transcriptional regulators [Transcription]; Region: GntR; COG1802 685039007379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685039007380 DNA-binding site [nucleotide binding]; DNA binding site 685039007381 FCD domain; Region: FCD; pfam07729 685039007382 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 685039007383 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 685039007384 DNA binding residues [nucleotide binding] 685039007385 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 685039007386 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 685039007387 synthetase active site [active] 685039007388 NTP binding site [chemical binding]; other site 685039007389 metal binding site [ion binding]; metal-binding site 685039007390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 685039007391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 685039007392 Predicted membrane protein [Function unknown]; Region: COG1289 685039007393 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 685039007394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039007395 D-galactonate transporter; Region: 2A0114; TIGR00893 685039007396 putative substrate translocation pore; other site 685039007397 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 685039007398 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 685039007399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685039007400 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685039007401 putative substrate translocation pore; other site 685039007402 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685039007403 MarR family; Region: MarR; pfam01047 685039007404 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 685039007405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039007406 Walker A/P-loop; other site 685039007407 ATP binding site [chemical binding]; other site 685039007408 Q-loop/lid; other site 685039007409 ABC transporter signature motif; other site 685039007410 Walker B; other site 685039007411 D-loop; other site 685039007412 H-loop/switch region; other site 685039007413 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 685039007414 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 685039007415 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 685039007416 Uncharacterized membrane protein [Function unknown]; Region: COG3949 685039007417 Predicted esterase [General function prediction only]; Region: COG0400 685039007418 putative hydrolase; Provisional; Region: PRK11460 685039007419 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 685039007420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685039007421 Zn binding site [ion binding]; other site 685039007422 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 685039007423 Zn binding site [ion binding]; other site 685039007424 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685039007425 MarR family; Region: MarR; pfam01047 685039007426 Predicted acetyltransferase [General function prediction only]; Region: COG2388 685039007427 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 685039007428 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 685039007429 putative metal binding site [ion binding]; other site 685039007430 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 685039007431 dimer interface [polypeptide binding]; other site 685039007432 FMN binding site [chemical binding]; other site 685039007433 D-lactate dehydrogenase; Provisional; Region: PRK12480 685039007434 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 685039007435 homodimer interface [polypeptide binding]; other site 685039007436 ligand binding site [chemical binding]; other site 685039007437 NAD binding site [chemical binding]; other site 685039007438 catalytic site [active] 685039007439 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 685039007440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685039007441 active site 685039007442 motif I; other site 685039007443 motif II; other site 685039007444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685039007445 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 685039007446 Walker A/P-loop; other site 685039007447 ATP binding site [chemical binding]; other site 685039007448 Q-loop/lid; other site 685039007449 ABC transporter signature motif; other site 685039007450 Walker B; other site 685039007451 D-loop; other site 685039007452 H-loop/switch region; other site 685039007453 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 685039007454 active site 685039007455 catalytic site [active] 685039007456 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 685039007457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039007458 Coenzyme A binding pocket [chemical binding]; other site 685039007459 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 685039007460 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 685039007461 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 685039007462 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 685039007463 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 685039007464 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 685039007465 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 685039007466 EamA-like transporter family; Region: EamA; pfam00892 685039007467 EamA-like transporter family; Region: EamA; pfam00892 685039007468 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 685039007469 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 685039007470 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 685039007471 catalytic residues [active] 685039007472 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 685039007473 active site 685039007474 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 685039007475 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 685039007476 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 685039007477 active site turn [active] 685039007478 phosphorylation site [posttranslational modification] 685039007479 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 685039007480 HPr interaction site; other site 685039007481 glycerol kinase (GK) interaction site [polypeptide binding]; other site 685039007482 active site 685039007483 phosphorylation site [posttranslational modification] 685039007484 pyruvate oxidase; Provisional; Region: PRK08611 685039007485 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 685039007486 PYR/PP interface [polypeptide binding]; other site 685039007487 tetramer interface [polypeptide binding]; other site 685039007488 dimer interface [polypeptide binding]; other site 685039007489 TPP binding site [chemical binding]; other site 685039007490 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685039007491 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 685039007492 TPP-binding site [chemical binding]; other site 685039007493 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 685039007494 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 685039007495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685039007496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685039007497 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 685039007498 putative dimerization interface [polypeptide binding]; other site 685039007499 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 685039007500 Surface antigen [General function prediction only]; Region: COG3942 685039007501 CHAP domain; Region: CHAP; pfam05257 685039007502 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 685039007503 homodimer interface [polypeptide binding]; other site 685039007504 catalytic residues [active] 685039007505 NAD binding site [chemical binding]; other site 685039007506 substrate binding pocket [chemical binding]; other site 685039007507 flexible flap; other site 685039007508 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 685039007509 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 685039007510 dimer interface [polypeptide binding]; other site 685039007511 active site 685039007512 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 685039007513 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 685039007514 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 685039007515 DNA binding site [nucleotide binding] 685039007516 active site 685039007517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039007518 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 685039007519 Walker A motif; other site 685039007520 ATP binding site [chemical binding]; other site 685039007521 Walker B motif; other site 685039007522 arginine finger; other site 685039007523 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 685039007524 UvrB/uvrC motif; Region: UVR; pfam02151 685039007525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685039007526 Walker A motif; other site 685039007527 ATP binding site [chemical binding]; other site 685039007528 Walker B motif; other site 685039007529 arginine finger; other site 685039007530 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 685039007531 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 685039007532 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 685039007533 G1 box; other site 685039007534 GTP/Mg2+ binding site [chemical binding]; other site 685039007535 Switch I region; other site 685039007536 G2 box; other site 685039007537 G3 box; other site 685039007538 Switch II region; other site 685039007539 G4 box; other site 685039007540 G5 box; other site 685039007541 Nucleoside recognition; Region: Gate; pfam07670 685039007542 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 685039007543 Nucleoside recognition; Region: Gate; pfam07670 685039007544 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 685039007545 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 685039007546 Protein export membrane protein; Region: SecD_SecF; cl14618 685039007547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685039007548 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 685039007549 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 685039007550 Glutamate binding site [chemical binding]; other site 685039007551 homodimer interface [polypeptide binding]; other site 685039007552 NAD binding site [chemical binding]; other site 685039007553 catalytic residues [active] 685039007554 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 685039007555 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 685039007556 active site 685039007557 substrate binding site [chemical binding]; other site 685039007558 trimer interface [polypeptide binding]; other site 685039007559 CoA binding site [chemical binding]; other site 685039007560 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 685039007561 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685039007562 metal-binding site [ion binding] 685039007563 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 685039007564 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685039007565 metal-binding site [ion binding] 685039007566 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685039007567 Soluble P-type ATPase [General function prediction only]; Region: COG4087 685039007568 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 685039007569 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685039007570 metal-binding site [ion binding] 685039007571 D-lactate dehydrogenase; Validated; Region: PRK08605 685039007572 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 685039007573 homodimer interface [polypeptide binding]; other site 685039007574 ligand binding site [chemical binding]; other site 685039007575 NAD binding site [chemical binding]; other site 685039007576 catalytic site [active] 685039007577 transaminase; Reviewed; Region: PRK08068 685039007578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685039007579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039007580 homodimer interface [polypeptide binding]; other site 685039007581 catalytic residue [active] 685039007582 phytoene desaturase; Region: crtI_fam; TIGR02734 685039007583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685039007584 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 685039007585 active site lid residues [active] 685039007586 substrate binding pocket [chemical binding]; other site 685039007587 catalytic residues [active] 685039007588 substrate-Mg2+ binding site; other site 685039007589 aspartate-rich region 1; other site 685039007590 aspartate-rich region 2; other site 685039007591 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 685039007592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 685039007593 active site 685039007594 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 685039007595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685039007596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685039007597 Surface antigen [General function prediction only]; Region: COG3942 685039007598 CHAP domain; Region: CHAP; pfam05257 685039007599 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 685039007600 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 685039007601 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 685039007602 catalytic triad [active] 685039007603 catalytic triad [active] 685039007604 oxyanion hole [active] 685039007605 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685039007606 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685039007607 catalytic residue [active] 685039007608 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 685039007609 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 685039007610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685039007611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685039007612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 685039007613 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 685039007614 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685039007615 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 685039007616 active site 685039007617 regulatory binding site [polypeptide binding]; other site 685039007618 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 685039007619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685039007620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685039007621 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 685039007622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685039007623 NAD(P) binding site [chemical binding]; other site 685039007624 active site 685039007625 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 685039007626 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685039007627 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 685039007628 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 685039007629 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 685039007630 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 685039007631 Nucleoside recognition; Region: Gate; pfam07670 685039007632 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 685039007633 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685039007634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 685039007635 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 685039007636 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 685039007637 Phosphotransferase enzyme family; Region: APH; pfam01636 685039007638 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 685039007639 active site 685039007640 ATP binding site [chemical binding]; other site 685039007641 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 685039007642 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 685039007643 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 685039007644 quinone interaction residues [chemical binding]; other site 685039007645 active site 685039007646 catalytic residues [active] 685039007647 FMN binding site [chemical binding]; other site 685039007648 substrate binding site [chemical binding]; other site 685039007649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 685039007650 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 685039007651 dimer interface [polypeptide binding]; other site 685039007652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685039007653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685039007654 Predicted acyl esterases [General function prediction only]; Region: COG2936 685039007655 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 685039007656 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 685039007657 tetramerization interface [polypeptide binding]; other site 685039007658 active site 685039007659 pantoate--beta-alanine ligase; Region: panC; TIGR00018 685039007660 Pantoate-beta-alanine ligase; Region: PanC; cd00560 685039007661 active site 685039007662 ATP-binding site [chemical binding]; other site 685039007663 pantoate-binding site; other site 685039007664 HXXH motif; other site 685039007665 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 685039007666 active site 685039007667 oligomerization interface [polypeptide binding]; other site 685039007668 metal binding site [ion binding]; metal-binding site 685039007669 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 685039007670 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 685039007671 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 685039007672 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 685039007673 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 685039007674 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 685039007675 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685039007676 NAD binding site [chemical binding]; other site 685039007677 dimer interface [polypeptide binding]; other site 685039007678 substrate binding site [chemical binding]; other site 685039007679 amino acid transporter; Region: 2A0306; TIGR00909 685039007680 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 685039007681 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 685039007682 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685039007683 inhibitor-cofactor binding pocket; inhibition site 685039007684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039007685 catalytic residue [active] 685039007686 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 685039007687 catalytic residue [active] 685039007688 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 685039007689 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 685039007690 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 685039007691 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685039007692 acyl-activating enzyme (AAE) consensus motif; other site 685039007693 AMP binding site [chemical binding]; other site 685039007694 active site 685039007695 CoA binding site [chemical binding]; other site 685039007696 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 685039007697 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 685039007698 choline dehydrogenase; Validated; Region: PRK02106 685039007699 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 685039007700 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 685039007701 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 685039007702 tetramerization interface [polypeptide binding]; other site 685039007703 NAD(P) binding site [chemical binding]; other site 685039007704 catalytic residues [active] 685039007705 Predicted transcriptional regulators [Transcription]; Region: COG1510 685039007706 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 685039007707 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 685039007708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685039007709 FeS/SAM binding site; other site 685039007710 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 685039007711 Class III ribonucleotide reductase; Region: RNR_III; cd01675 685039007712 effector binding site; other site 685039007713 active site 685039007714 Zn binding site [ion binding]; other site 685039007715 glycine loop; other site 685039007716 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 685039007717 Citrate transporter; Region: CitMHS; pfam03600 685039007718 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 685039007719 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 685039007720 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 685039007721 Flavodoxin; Region: Flavodoxin_1; pfam00258 685039007722 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 685039007723 FAD binding pocket [chemical binding]; other site 685039007724 FAD binding motif [chemical binding]; other site 685039007725 catalytic residues [active] 685039007726 NAD binding pocket [chemical binding]; other site 685039007727 phosphate binding motif [ion binding]; other site 685039007728 beta-alpha-beta structure motif; other site 685039007729 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 685039007730 catalytic residues [active] 685039007731 dimer interface [polypeptide binding]; other site 685039007732 FtsX-like permease family; Region: FtsX; pfam02687 685039007733 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685039007734 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685039007735 Walker A/P-loop; other site 685039007736 ATP binding site [chemical binding]; other site 685039007737 Q-loop/lid; other site 685039007738 ABC transporter signature motif; other site 685039007739 Walker B; other site 685039007740 D-loop; other site 685039007741 H-loop/switch region; other site 685039007742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685039007743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685039007744 ATP binding site [chemical binding]; other site 685039007745 Mg2+ binding site [ion binding]; other site 685039007746 G-X-G motif; other site 685039007747 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685039007748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685039007749 active site 685039007750 phosphorylation site [posttranslational modification] 685039007751 intermolecular recognition site; other site 685039007752 dimerization interface [polypeptide binding]; other site 685039007753 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685039007754 DNA binding site [nucleotide binding] 685039007755 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 685039007756 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 685039007757 dimer interface [polypeptide binding]; other site 685039007758 active site 685039007759 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 685039007760 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 685039007761 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685039007762 MarR family; Region: MarR_2; pfam12802 685039007763 Predicted esterase [General function prediction only]; Region: COG0627 685039007764 S-formylglutathione hydrolase; Region: PLN02442 685039007765 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 685039007766 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 685039007767 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 685039007768 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 685039007769 ligand binding site [chemical binding]; other site 685039007770 flexible hinge region; other site 685039007771 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 685039007772 carbamate kinase; Reviewed; Region: PRK12686 685039007773 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 685039007774 putative substrate binding site [chemical binding]; other site 685039007775 nucleotide binding site [chemical binding]; other site 685039007776 nucleotide binding site [chemical binding]; other site 685039007777 homodimer interface [polypeptide binding]; other site 685039007778 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 685039007779 ornithine carbamoyltransferase; Validated; Region: PRK02102 685039007780 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 685039007781 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 685039007782 arginine deiminase; Provisional; Region: PRK01388 685039007783 Arginine repressor [Transcription]; Region: ArgR; COG1438 685039007784 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 685039007785 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 685039007786 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 685039007787 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 685039007788 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 685039007789 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 685039007790 active site 685039007791 Zn binding site [ion binding]; other site 685039007792 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 685039007793 HTH domain; Region: HTH_11; pfam08279 685039007794 PRD domain; Region: PRD; pfam00874 685039007795 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 685039007796 active site 685039007797 P-loop; other site 685039007798 phosphorylation site [posttranslational modification] 685039007799 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685039007800 active site 685039007801 phosphorylation site [posttranslational modification] 685039007802 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 685039007803 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 685039007804 active site 685039007805 P-loop; other site 685039007806 phosphorylation site [posttranslational modification] 685039007807 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 685039007808 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 685039007809 active site 685039007810 phosphorylation site [posttranslational modification] 685039007811 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 685039007812 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 685039007813 Predicted membrane protein [Function unknown]; Region: COG1511 685039007814 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 685039007815 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 685039007816 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 685039007817 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 685039007818 CHAP domain; Region: CHAP; pfam05257 685039007819 Transposase; Region: HTH_Tnp_1; cl17663 685039007820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039007821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 685039007822 Helix-turn-helix domain; Region: HTH_28; pfam13518 685039007823 HTH-like domain; Region: HTH_21; pfam13276 685039007824 Integrase core domain; Region: rve; pfam00665 685039007825 Integrase core domain; Region: rve_3; cl15866 685039007826 Isochorismatase family; Region: Isochorismatase; pfam00857 685039007827 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 685039007828 catalytic triad [active] 685039007829 conserved cis-peptide bond; other site 685039007830 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 685039007831 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 685039007832 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 685039007833 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 685039007834 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 685039007835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 685039007836 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 685039007837 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 685039007838 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 685039007839 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 685039007840 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 685039007841 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 685039007842 SecY translocase; Region: SecY; pfam00344 685039007843 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 685039007844 legume lectins; Region: lectin_L-type; cd01951 685039007845 homotetramer interaction site [polypeptide binding]; other site 685039007846 carbohydrate binding site [chemical binding]; other site 685039007847 metal binding site [ion binding]; metal-binding site 685039007848 Putative Ig domain; Region: He_PIG; pfam05345 685039007849 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 685039007850 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 685039007851 methionine sulfoxide reductase A; Provisional; Region: PRK05528 685039007852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 685039007853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685039007854 Coenzyme A binding pocket [chemical binding]; other site 685039007855 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 685039007856 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 685039007857 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685039007858 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 685039007859 Chain length determinant protein; Region: Wzz; cl15801 685039007860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685039007861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685039007862 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 685039007863 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 685039007864 DXD motif; other site 685039007865 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 685039007866 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 685039007867 Acyltransferase family; Region: Acyl_transf_3; pfam01757 685039007868 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 685039007869 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 685039007870 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 685039007871 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 685039007872 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 685039007873 metal binding site [ion binding]; metal-binding site 685039007874 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 685039007875 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 685039007876 substrate binding site [chemical binding]; other site 685039007877 glutamase interaction surface [polypeptide binding]; other site 685039007878 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 685039007879 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 685039007880 catalytic residues [active] 685039007881 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 685039007882 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 685039007883 putative active site [active] 685039007884 oxyanion strand; other site 685039007885 catalytic triad [active] 685039007886 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 685039007887 putative active site pocket [active] 685039007888 4-fold oligomerization interface [polypeptide binding]; other site 685039007889 metal binding residues [ion binding]; metal-binding site 685039007890 3-fold/trimer interface [polypeptide binding]; other site 685039007891 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 685039007892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685039007893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685039007894 homodimer interface [polypeptide binding]; other site 685039007895 catalytic residue [active] 685039007896 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 685039007897 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 685039007898 NAD binding site [chemical binding]; other site 685039007899 dimerization interface [polypeptide binding]; other site 685039007900 product binding site; other site 685039007901 substrate binding site [chemical binding]; other site 685039007902 zinc binding site [ion binding]; other site 685039007903 catalytic residues [active] 685039007904 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 685039007905 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 685039007906 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 685039007907 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 685039007908 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 685039007909 putative active site [active] 685039007910 Uncharacterized conserved protein [Function unknown]; Region: COG2353 685039007911 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 685039007912 Strictosidine synthase; Region: Str_synth; pfam03088 685039007913 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 685039007914 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 685039007915 active site residue [active] 685039007916 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 685039007917 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 685039007918 putative substrate binding pocket [chemical binding]; other site 685039007919 AC domain interface; other site 685039007920 catalytic triad [active] 685039007921 AB domain interface; other site 685039007922 interchain disulfide; other site 685039007923 DinB superfamily; Region: DinB_2; pfam12867 685039007924 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 685039007925 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 685039007926 transmembrane helices; other site 685039007927 Predicted permeases [General function prediction only]; Region: RarD; COG2962 685039007928 hypothetical protein; Provisional; Region: PRK07758 685039007929 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 685039007930 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 685039007931 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 685039007932 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685039007933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685039007934 Walker A/P-loop; other site 685039007935 ATP binding site [chemical binding]; other site 685039007936 Q-loop/lid; other site 685039007937 ABC transporter signature motif; other site 685039007938 Walker B; other site 685039007939 D-loop; other site 685039007940 H-loop/switch region; other site 685039007941 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 685039007942 FtsX-like permease family; Region: FtsX; pfam02687 685039007943 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685039007944 DNA-binding site [nucleotide binding]; DNA binding site 685039007945 RNA-binding motif; other site 685039007946 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 685039007947 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 685039007948 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 685039007949 ParB-like nuclease domain; Region: ParBc; pfam02195 685039007950 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 685039007951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685039007952 S-adenosylmethionine binding site [chemical binding]; other site 685039007953 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 685039007954 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 685039007955 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 685039007956 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 685039007957 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 685039007958 trmE is a tRNA modification GTPase; Region: trmE; cd04164 685039007959 G1 box; other site 685039007960 GTP/Mg2+ binding site [chemical binding]; other site 685039007961 Switch I region; other site 685039007962 G2 box; other site 685039007963 Switch II region; other site 685039007964 G3 box; other site 685039007965 G4 box; other site 685039007966 G5 box; other site 685039007967 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 685039007968 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399