-- dump date 20140620_073717 -- class Genbank::misc_feature -- table misc_feature_note -- id note 681288000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 681288000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 681288000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288000004 Walker A motif; other site 681288000005 ATP binding site [chemical binding]; other site 681288000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 681288000007 Walker B motif; other site 681288000008 arginine finger; other site 681288000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 681288000010 DnaA box-binding interface [nucleotide binding]; other site 681288000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 681288000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 681288000013 putative DNA binding surface [nucleotide binding]; other site 681288000014 dimer interface [polypeptide binding]; other site 681288000015 beta-clamp/clamp loader binding surface; other site 681288000016 beta-clamp/translesion DNA polymerase binding surface; other site 681288000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 681288000018 recF protein; Region: recf; TIGR00611 681288000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 681288000020 Walker A/P-loop; other site 681288000021 ATP binding site [chemical binding]; other site 681288000022 Q-loop/lid; other site 681288000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288000024 ABC transporter signature motif; other site 681288000025 Walker B; other site 681288000026 D-loop; other site 681288000027 H-loop/switch region; other site 681288000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 681288000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288000030 Mg2+ binding site [ion binding]; other site 681288000031 G-X-G motif; other site 681288000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 681288000033 anchoring element; other site 681288000034 dimer interface [polypeptide binding]; other site 681288000035 ATP binding site [chemical binding]; other site 681288000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 681288000037 active site 681288000038 putative metal-binding site [ion binding]; other site 681288000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 681288000040 DNA gyrase subunit A; Validated; Region: PRK05560 681288000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 681288000042 CAP-like domain; other site 681288000043 active site 681288000044 primary dimer interface [polypeptide binding]; other site 681288000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 681288000052 putative substrate binding site [chemical binding]; other site 681288000053 putative ATP binding site [chemical binding]; other site 681288000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 681288000055 active sites [active] 681288000056 tetramer interface [polypeptide binding]; other site 681288000057 SAAV_0009 681288000058 seryl-tRNA synthetase; Provisional; Region: PRK05431 681288000059 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 681288000060 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 681288000061 dimer interface [polypeptide binding]; other site 681288000062 active site 681288000063 motif 1; other site 681288000064 motif 2; other site 681288000065 motif 3; other site 681288000066 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 681288000067 Predicted membrane protein [Function unknown]; Region: COG4392 681288000068 SAAV_0013 681288000069 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 681288000070 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 681288000071 Predicted membrane protein [Function unknown]; Region: COG4241 681288000072 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 681288000073 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 681288000074 DHH family; Region: DHH; pfam01368 681288000075 DHHA1 domain; Region: DHHA1; pfam02272 681288000076 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 681288000077 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 681288000078 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 681288000079 replicative DNA helicase; Region: DnaB; TIGR00665 681288000080 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 681288000081 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 681288000082 Walker A motif; other site 681288000083 ATP binding site [chemical binding]; other site 681288000084 Walker B motif; other site 681288000085 DNA binding loops [nucleotide binding] 681288000086 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 681288000087 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 681288000088 GDP-binding site [chemical binding]; other site 681288000089 ACT binding site; other site 681288000090 IMP binding site; other site 681288000091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288000092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288000093 active site 681288000094 phosphorylation site [posttranslational modification] 681288000095 intermolecular recognition site; other site 681288000096 dimerization interface [polypeptide binding]; other site 681288000097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288000098 DNA binding site [nucleotide binding] 681288000099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 681288000100 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 681288000101 dimerization interface [polypeptide binding]; other site 681288000102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 681288000103 putative active site [active] 681288000104 heme pocket [chemical binding]; other site 681288000105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288000106 dimer interface [polypeptide binding]; other site 681288000107 phosphorylation site [posttranslational modification] 681288000108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288000109 ATP binding site [chemical binding]; other site 681288000110 Mg2+ binding site [ion binding]; other site 681288000111 G-X-G motif; other site 681288000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 681288000113 YycH protein; Region: YycH; pfam07435 681288000114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 681288000115 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 681288000116 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 681288000117 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 681288000118 putative active site [active] 681288000119 putative metal binding site [ion binding]; other site 681288000120 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 681288000121 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 681288000122 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 681288000123 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 681288000124 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 681288000125 phosphate binding site [ion binding]; other site 681288000126 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 681288000127 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 681288000128 putative homodimer interface [polypeptide binding]; other site 681288000129 putative homotetramer interface [polypeptide binding]; other site 681288000130 putative metal binding site [ion binding]; other site 681288000131 putative homodimer-homodimer interface [polypeptide binding]; other site 681288000132 putative allosteric switch controlling residues; other site 681288000133 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 681288000134 active site residue [active] 681288000135 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 681288000136 CPxP motif; other site 681288000137 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 681288000138 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 681288000139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 681288000140 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 681288000141 active site residue [active] 681288000142 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 681288000143 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 681288000144 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 681288000145 FMN binding site [chemical binding]; other site 681288000146 active site 681288000147 catalytic residues [active] 681288000148 substrate binding site [chemical binding]; other site 681288000149 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 681288000150 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 681288000151 Part of AAA domain; Region: AAA_19; pfam13245 681288000152 AAA domain; Region: AAA_12; pfam13087 681288000153 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 681288000154 active site 681288000155 catalytic site [active] 681288000156 putative metal binding site [ion binding]; other site 681288000157 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288000158 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288000159 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288000160 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 681288000161 Integrase core domain; Region: rve; pfam00665 681288000162 Integrase core domain; Region: rve_3; cl15866 681288000163 Helix-turn-helix domain; Region: HTH_38; pfam13936 681288000164 Winged helix-turn helix; Region: HTH_29; pfam13551 681288000165 Homeodomain-like domain; Region: HTH_32; pfam13565 681288000166 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 681288000167 Surface antigen [General function prediction only]; Region: COG3942 681288000168 CHAP domain; Region: CHAP; pfam05257 681288000169 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 681288000170 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 681288000171 Mitochondrial 28S ribosomal protein S30 (PDCD9); Region: PDCD9; pfam07147 681288000172 AAA-like domain; Region: AAA_10; pfam12846 681288000173 TcpE family; Region: TcpE; pfam12648 681288000174 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 681288000175 Replication initiation factor; Region: Rep_trans; pfam02486 681288000176 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 681288000177 glyoxylate carboligase; Provisional; Region: PRK11269 681288000178 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288000179 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288000180 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288000181 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 681288000182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288000183 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 681288000184 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 681288000185 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 681288000186 metal binding site [ion binding]; metal-binding site 681288000187 dimer interface [polypeptide binding]; other site 681288000188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000189 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288000190 putative substrate translocation pore; other site 681288000191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000192 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 681288000193 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 681288000194 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 681288000195 PhoU domain; Region: PhoU; pfam01895 681288000196 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 681288000197 EamA-like transporter family; Region: EamA; pfam00892 681288000198 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 681288000199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288000200 DNA-binding site [nucleotide binding]; DNA binding site 681288000201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288000202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288000203 homodimer interface [polypeptide binding]; other site 681288000204 catalytic residue [active] 681288000205 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 681288000206 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 681288000207 L-lactate permease; Region: Lactate_perm; cl00701 681288000208 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288000209 Transcriptional regulators [Transcription]; Region: MarR; COG1846 681288000210 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288000211 Transcriptional regulators [Transcription]; Region: MarR; COG1846 681288000212 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 681288000213 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288000214 ABC-ATPase subunit interface; other site 681288000215 dimer interface [polypeptide binding]; other site 681288000216 putative PBP binding regions; other site 681288000217 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 681288000218 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288000219 ABC-ATPase subunit interface; other site 681288000220 dimer interface [polypeptide binding]; other site 681288000221 putative PBP binding regions; other site 681288000222 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 681288000223 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 681288000224 siderophore binding site; other site 681288000225 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 681288000226 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 681288000227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288000228 catalytic residue [active] 681288000229 dimer interface [polypeptide binding]; other site 681288000230 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 681288000231 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 681288000232 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 681288000233 IucA / IucC family; Region: IucA_IucC; pfam04183 681288000234 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 681288000235 drug efflux system protein MdtG; Provisional; Region: PRK09874 681288000236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000237 putative substrate translocation pore; other site 681288000238 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 681288000239 IucA / IucC family; Region: IucA_IucC; pfam04183 681288000240 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 681288000241 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 681288000242 IucA / IucC family; Region: IucA_IucC; pfam04183 681288000243 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 681288000244 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 681288000245 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 681288000246 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 681288000247 dimer interface [polypeptide binding]; other site 681288000248 active site 681288000249 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288000250 catalytic residues [active] 681288000251 substrate binding site [chemical binding]; other site 681288000252 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 681288000253 ParB-like nuclease domain; Region: ParBc; pfam02195 681288000254 acetoin reductase; Validated; Region: PRK08643 681288000255 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 681288000256 NAD binding site [chemical binding]; other site 681288000257 homotetramer interface [polypeptide binding]; other site 681288000258 homodimer interface [polypeptide binding]; other site 681288000259 active site 681288000260 substrate binding site [chemical binding]; other site 681288000261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000262 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 681288000263 NAD(P) binding site [chemical binding]; other site 681288000264 active site 681288000265 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 681288000266 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 681288000267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 681288000268 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 681288000269 putative ADP-binding pocket [chemical binding]; other site 681288000270 O-Antigen Polymerase; Region: Wzy_C; cl04850 681288000271 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 681288000272 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 681288000273 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 681288000274 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 681288000275 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 681288000276 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 681288000277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288000278 DNA-binding site [nucleotide binding]; DNA binding site 681288000279 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 681288000280 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 681288000281 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288000282 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 681288000283 intersubunit interface [polypeptide binding]; other site 681288000284 active site 681288000285 catalytic residue [active] 681288000286 phosphopentomutase; Provisional; Region: PRK05362 681288000287 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 681288000288 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 681288000289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000290 dimer interface [polypeptide binding]; other site 681288000291 conserved gate region; other site 681288000292 putative PBP binding loops; other site 681288000293 ABC-ATPase subunit interface; other site 681288000294 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 681288000295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000296 dimer interface [polypeptide binding]; other site 681288000297 conserved gate region; other site 681288000298 ABC-ATPase subunit interface; other site 681288000299 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 681288000300 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 681288000301 Walker A/P-loop; other site 681288000302 ATP binding site [chemical binding]; other site 681288000303 Q-loop/lid; other site 681288000304 ABC transporter signature motif; other site 681288000305 Walker B; other site 681288000306 D-loop; other site 681288000307 H-loop/switch region; other site 681288000308 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 681288000309 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 681288000310 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 681288000311 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 681288000312 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 681288000313 active site 681288000314 metal binding site [ion binding]; metal-binding site 681288000315 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 681288000316 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 681288000317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288000318 non-specific DNA binding site [nucleotide binding]; other site 681288000319 salt bridge; other site 681288000320 sequence-specific DNA binding site [nucleotide binding]; other site 681288000321 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 681288000322 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 681288000323 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 681288000324 putative catalytic cysteine [active] 681288000325 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 681288000326 putative active site [active] 681288000327 metal binding site [ion binding]; metal-binding site 681288000328 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 681288000329 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 681288000330 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 681288000331 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 681288000332 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 681288000333 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 681288000334 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 681288000335 NAD(P) binding site [chemical binding]; other site 681288000336 homodimer interface [polypeptide binding]; other site 681288000337 substrate binding site [chemical binding]; other site 681288000338 active site 681288000339 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 681288000340 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 681288000341 NAD(P) binding site [chemical binding]; other site 681288000342 homodimer interface [polypeptide binding]; other site 681288000343 substrate binding site [chemical binding]; other site 681288000344 active site 681288000345 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 681288000346 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 681288000347 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 681288000348 putative NAD(P) binding site [chemical binding]; other site 681288000349 active site 681288000350 putative substrate binding site [chemical binding]; other site 681288000351 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 681288000352 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 681288000353 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 681288000354 active site 681288000355 homodimer interface [polypeptide binding]; other site 681288000356 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 681288000357 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 681288000358 trimer interface [polypeptide binding]; other site 681288000359 active site 681288000360 substrate binding site [chemical binding]; other site 681288000361 CoA binding site [chemical binding]; other site 681288000362 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 681288000363 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 681288000364 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 681288000365 O-Antigen ligase; Region: Wzy_C; pfam04932 681288000366 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 681288000367 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 681288000368 Bacterial sugar transferase; Region: Bac_transf; pfam02397 681288000369 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 681288000370 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 681288000371 putative NAD(P) binding site [chemical binding]; other site 681288000372 active site 681288000373 putative substrate binding site [chemical binding]; other site 681288000374 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 681288000375 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 681288000376 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 681288000377 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 681288000378 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 681288000379 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 681288000380 active site 681288000381 homodimer interface [polypeptide binding]; other site 681288000382 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 681288000383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 681288000384 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 681288000385 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 681288000386 NAD(P) binding site [chemical binding]; other site 681288000387 catalytic residues [active] 681288000388 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 681288000389 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 681288000390 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 681288000391 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 681288000392 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 681288000393 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 681288000394 Walker A/P-loop; other site 681288000395 ATP binding site [chemical binding]; other site 681288000396 Q-loop/lid; other site 681288000397 ABC transporter signature motif; other site 681288000398 Walker B; other site 681288000399 D-loop; other site 681288000400 H-loop/switch region; other site 681288000401 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 681288000402 NMT1-like family; Region: NMT1_2; pfam13379 681288000403 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 681288000404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 681288000405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 681288000406 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 681288000407 active site 681288000408 Uncharacterized conserved protein [Function unknown]; Region: COG5609 681288000409 putative transporter; Provisional; Region: PRK10054 681288000410 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 681288000411 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 681288000412 acyl-activating enzyme (AAE) consensus motif; other site 681288000413 AMP binding site [chemical binding]; other site 681288000414 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 681288000415 Condensation domain; Region: Condensation; pfam00668 681288000416 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 681288000417 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 681288000418 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 681288000419 acyl-activating enzyme (AAE) consensus motif; other site 681288000420 AMP binding site [chemical binding]; other site 681288000421 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 681288000422 thioester reductase domain; Region: Thioester-redct; TIGR01746 681288000423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000424 NAD(P) binding site [chemical binding]; other site 681288000425 active site 681288000426 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 681288000427 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 681288000428 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 681288000429 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 681288000430 nucleotide binding site [chemical binding]; other site 681288000431 N-acetyl-L-glutamate binding site [chemical binding]; other site 681288000432 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 681288000433 heterotetramer interface [polypeptide binding]; other site 681288000434 active site pocket [active] 681288000435 cleavage site 681288000436 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 681288000437 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 681288000438 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 681288000439 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288000440 inhibitor-cofactor binding pocket; inhibition site 681288000441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288000442 catalytic residue [active] 681288000443 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 681288000444 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 681288000445 Isochorismatase family; Region: Isochorismatase; pfam00857 681288000446 catalytic triad [active] 681288000447 conserved cis-peptide bond; other site 681288000448 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 681288000449 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 681288000450 dimer interface [polypeptide binding]; other site 681288000451 PYR/PP interface [polypeptide binding]; other site 681288000452 TPP binding site [chemical binding]; other site 681288000453 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 681288000454 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 681288000455 TPP-binding site [chemical binding]; other site 681288000456 dimer interface [polypeptide binding]; other site 681288000457 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 681288000458 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 681288000459 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288000460 active site turn [active] 681288000461 phosphorylation site [posttranslational modification] 681288000462 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 681288000463 HPr interaction site; other site 681288000464 glycerol kinase (GK) interaction site [polypeptide binding]; other site 681288000465 active site 681288000466 phosphorylation site [posttranslational modification] 681288000467 Uncharacterized conserved protein [Function unknown]; Region: COG3589 681288000468 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 681288000469 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 681288000470 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 681288000471 putative active site [active] 681288000472 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 681288000473 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288000474 active site turn [active] 681288000475 phosphorylation site [posttranslational modification] 681288000476 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 681288000477 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 681288000478 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 681288000479 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 681288000480 putative active site [active] 681288000481 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 681288000482 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 681288000483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288000484 ATP binding site [chemical binding]; other site 681288000485 putative Mg++ binding site [ion binding]; other site 681288000486 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 681288000487 HlyD family secretion protein; Region: HlyD_3; pfam13437 681288000488 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 681288000489 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 681288000490 FtsX-like permease family; Region: FtsX; pfam02687 681288000491 Integral membrane protein DUF95; Region: DUF95; cl00572 681288000492 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 681288000493 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 681288000494 Walker A/P-loop; other site 681288000495 ATP binding site [chemical binding]; other site 681288000496 Q-loop/lid; other site 681288000497 ABC transporter signature motif; other site 681288000498 Walker B; other site 681288000499 D-loop; other site 681288000500 H-loop/switch region; other site 681288000501 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 681288000502 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 681288000503 Walker A/P-loop; other site 681288000504 ATP binding site [chemical binding]; other site 681288000505 Q-loop/lid; other site 681288000506 ABC transporter signature motif; other site 681288000507 Walker B; other site 681288000508 D-loop; other site 681288000509 H-loop/switch region; other site 681288000510 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 681288000511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 681288000512 Walker A/P-loop; other site 681288000513 ATP binding site [chemical binding]; other site 681288000514 Q-loop/lid; other site 681288000515 ABC transporter signature motif; other site 681288000516 Walker B; other site 681288000517 D-loop; other site 681288000518 H-loop/switch region; other site 681288000519 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 681288000520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000521 dimer interface [polypeptide binding]; other site 681288000522 conserved gate region; other site 681288000523 putative PBP binding loops; other site 681288000524 ABC-ATPase subunit interface; other site 681288000525 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 681288000526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000527 dimer interface [polypeptide binding]; other site 681288000528 conserved gate region; other site 681288000529 ABC-ATPase subunit interface; other site 681288000530 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 681288000531 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 681288000532 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 681288000533 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 681288000534 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 681288000535 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 681288000536 azoreductase; Reviewed; Region: PRK00170 681288000537 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 681288000538 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 681288000539 Peptidase family M23; Region: Peptidase_M23; pfam01551 681288000540 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 681288000541 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 681288000542 Walker A/P-loop; other site 681288000543 ATP binding site [chemical binding]; other site 681288000544 Q-loop/lid; other site 681288000545 ABC transporter signature motif; other site 681288000546 Walker B; other site 681288000547 D-loop; other site 681288000548 H-loop/switch region; other site 681288000549 TOBE domain; Region: TOBE; pfam03459 681288000550 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 681288000551 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 681288000552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000553 dimer interface [polypeptide binding]; other site 681288000554 conserved gate region; other site 681288000555 ABC-ATPase subunit interface; other site 681288000556 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 681288000557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000558 dimer interface [polypeptide binding]; other site 681288000559 conserved gate region; other site 681288000560 putative PBP binding loops; other site 681288000561 ABC-ATPase subunit interface; other site 681288000562 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 681288000563 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 681288000564 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 681288000565 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 681288000566 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 681288000567 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 681288000568 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 681288000569 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 681288000570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 681288000571 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 681288000572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000573 putative substrate translocation pore; other site 681288000574 Response regulator receiver domain; Region: Response_reg; pfam00072 681288000575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288000576 active site 681288000577 phosphorylation site [posttranslational modification] 681288000578 intermolecular recognition site; other site 681288000579 dimerization interface [polypeptide binding]; other site 681288000580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288000581 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 681288000582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288000583 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 681288000584 Histidine kinase; Region: His_kinase; pfam06580 681288000585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288000586 ATP binding site [chemical binding]; other site 681288000587 Mg2+ binding site [ion binding]; other site 681288000588 G-X-G motif; other site 681288000589 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 681288000590 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 681288000591 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 681288000592 Pyruvate formate lyase 1; Region: PFL1; cd01678 681288000593 coenzyme A binding site [chemical binding]; other site 681288000594 active site 681288000595 catalytic residues [active] 681288000596 glycine loop; other site 681288000597 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 681288000598 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288000599 FeS/SAM binding site; other site 681288000600 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 681288000601 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 681288000602 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 681288000603 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 681288000604 putative active site [active] 681288000605 catalytic site [active] 681288000606 putative metal binding site [ion binding]; other site 681288000607 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 681288000608 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 681288000609 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000610 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000611 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000612 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000613 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000614 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000615 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 681288000616 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 681288000617 dimer interface [polypeptide binding]; other site 681288000618 active site 681288000619 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 681288000620 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 681288000621 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 681288000622 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 681288000623 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 681288000624 substrate binding site [chemical binding]; other site 681288000625 oxyanion hole (OAH) forming residues; other site 681288000626 trimer interface [polypeptide binding]; other site 681288000627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 681288000628 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 681288000629 active site 681288000630 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 681288000631 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 681288000632 acyl-activating enzyme (AAE) consensus motif; other site 681288000633 AMP binding site [chemical binding]; other site 681288000634 active site 681288000635 CoA binding site [chemical binding]; other site 681288000636 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 681288000637 Coenzyme A transferase; Region: CoA_trans; smart00882 681288000638 Coenzyme A transferase; Region: CoA_trans; cl17247 681288000639 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 681288000640 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 681288000641 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 681288000642 Uncharacterized conserved protein [Function unknown]; Region: COG3189 681288000643 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 681288000644 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 681288000645 heme-binding site [chemical binding]; other site 681288000646 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 681288000647 FAD binding pocket [chemical binding]; other site 681288000648 FAD binding motif [chemical binding]; other site 681288000649 phosphate binding motif [ion binding]; other site 681288000650 beta-alpha-beta structure motif; other site 681288000651 NAD binding pocket [chemical binding]; other site 681288000652 Heme binding pocket [chemical binding]; other site 681288000653 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 681288000654 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 681288000655 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288000656 NAD binding site [chemical binding]; other site 681288000657 dimer interface [polypeptide binding]; other site 681288000658 substrate binding site [chemical binding]; other site 681288000659 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 681288000660 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 681288000661 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288000662 active site turn [active] 681288000663 phosphorylation site [posttranslational modification] 681288000664 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 681288000665 active site 681288000666 tetramer interface [polypeptide binding]; other site 681288000667 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 681288000668 Mga helix-turn-helix domain; Region: Mga; pfam05043 681288000669 PRD domain; Region: PRD; pfam00874 681288000670 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 681288000671 active site 681288000672 P-loop; other site 681288000673 phosphorylation site [posttranslational modification] 681288000674 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288000675 active site 681288000676 phosphorylation site [posttranslational modification] 681288000677 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288000678 active site 681288000679 phosphorylation site [posttranslational modification] 681288000680 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 681288000681 active site 681288000682 P-loop; other site 681288000683 phosphorylation site [posttranslational modification] 681288000684 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 681288000685 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 681288000686 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 681288000687 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 681288000688 putative NAD(P) binding site [chemical binding]; other site 681288000689 catalytic Zn binding site [ion binding]; other site 681288000690 structural Zn binding site [ion binding]; other site 681288000691 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 681288000692 substrate binding site; other site 681288000693 dimer interface; other site 681288000694 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 681288000695 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 681288000696 putative NAD(P) binding site [chemical binding]; other site 681288000697 putative catalytic Zn binding site [ion binding]; other site 681288000698 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 681288000699 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 681288000700 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 681288000701 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 681288000702 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 681288000703 substrate binding site; other site 681288000704 dimer interface; other site 681288000705 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 681288000706 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 681288000707 putative NAD(P) binding site [chemical binding]; other site 681288000708 putative catalytic Zn binding site [ion binding]; other site 681288000709 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 681288000710 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 681288000711 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 681288000712 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 681288000713 active site 681288000714 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 681288000715 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 681288000716 Hemerythrin-like domain; Region: Hr-like; cd12108 681288000717 Fe binding site [ion binding]; other site 681288000718 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 681288000719 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 681288000720 Histidine kinase; Region: His_kinase; pfam06580 681288000721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288000722 Mg2+ binding site [ion binding]; other site 681288000723 G-X-G motif; other site 681288000724 two-component response regulator; Provisional; Region: PRK14084 681288000725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288000726 active site 681288000727 phosphorylation site [posttranslational modification] 681288000728 intermolecular recognition site; other site 681288000729 dimerization interface [polypeptide binding]; other site 681288000730 LytTr DNA-binding domain; Region: LytTR; pfam04397 681288000731 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 681288000732 antiholin-like protein LrgB; Provisional; Region: PRK04288 681288000733 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 681288000734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288000735 DNA-binding site [nucleotide binding]; DNA binding site 681288000736 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 681288000737 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 681288000738 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 681288000739 HPr interaction site; other site 681288000740 glycerol kinase (GK) interaction site [polypeptide binding]; other site 681288000741 active site 681288000742 phosphorylation site [posttranslational modification] 681288000743 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 681288000744 beta-galactosidase; Region: BGL; TIGR03356 681288000745 Methyltransferase domain; Region: Methyltransf_31; pfam13847 681288000746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288000747 S-adenosylmethionine binding site [chemical binding]; other site 681288000748 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 681288000749 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 681288000750 substrate binding site [chemical binding]; other site 681288000751 dimer interface [polypeptide binding]; other site 681288000752 ATP binding site [chemical binding]; other site 681288000753 D-ribose pyranase; Provisional; Region: PRK11797 681288000754 Sugar transport protein; Region: Sugar_transport; pfam06800 681288000755 Transcriptional regulators [Transcription]; Region: PurR; COG1609 681288000756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 681288000757 DNA binding site [nucleotide binding] 681288000758 domain linker motif; other site 681288000759 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 681288000760 dimerization interface [polypeptide binding]; other site 681288000761 ligand binding site [chemical binding]; other site 681288000762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000764 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 681288000765 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 681288000766 active site 681288000767 Surface antigen [General function prediction only]; Region: COG3942 681288000768 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 681288000769 Peptidase family M23; Region: Peptidase_M23; pfam01551 681288000770 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 681288000771 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 681288000772 Walker A/P-loop; other site 681288000773 ATP binding site [chemical binding]; other site 681288000774 Q-loop/lid; other site 681288000775 ABC transporter signature motif; other site 681288000776 Walker B; other site 681288000777 D-loop; other site 681288000778 H-loop/switch region; other site 681288000779 Surface antigen [General function prediction only]; Region: COG3942 681288000780 CHAP domain; Region: CHAP; pfam05257 681288000781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 681288000782 Predicted membrane protein [Function unknown]; Region: COG1511 681288000783 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 681288000784 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 681288000785 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 681288000786 Uncharacterized small protein [Function unknown]; Region: COG5417 681288000787 Predicted membrane protein [Function unknown]; Region: COG4499 681288000788 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 681288000789 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 681288000790 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 681288000791 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 681288000792 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 681288000793 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 681288000794 Uncharacterized conserved protein [Function unknown]; Region: COG5444 681288000795 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 681288000796 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000797 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000798 Protein of unknown function, DUF600; Region: DUF600; pfam04634 681288000799 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000800 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000801 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000802 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 681288000803 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 681288000804 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 681288000805 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 681288000806 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 681288000807 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 681288000808 FtsX-like permease family; Region: FtsX; pfam02687 681288000809 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288000810 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 681288000811 Walker A/P-loop; other site 681288000812 ATP binding site [chemical binding]; other site 681288000813 Q-loop/lid; other site 681288000814 ABC transporter signature motif; other site 681288000815 Walker B; other site 681288000816 D-loop; other site 681288000817 H-loop/switch region; other site 681288000818 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 681288000819 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 681288000820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288000821 non-specific DNA binding site [nucleotide binding]; other site 681288000822 salt bridge; other site 681288000823 sequence-specific DNA binding site [nucleotide binding]; other site 681288000824 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 681288000825 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 681288000826 substrate binding site [chemical binding]; other site 681288000827 ATP binding site [chemical binding]; other site 681288000828 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 681288000829 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 681288000830 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 681288000831 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 681288000832 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 681288000833 putative transporter; Provisional; Region: PRK10484 681288000834 Na binding site [ion binding]; other site 681288000835 N-acetylneuraminate lyase; Provisional; Region: PRK04147 681288000836 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 681288000837 inhibitor site; inhibition site 681288000838 active site 681288000839 dimer interface [polypeptide binding]; other site 681288000840 catalytic residue [active] 681288000841 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 681288000842 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 681288000843 nucleotide binding site [chemical binding]; other site 681288000844 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 681288000845 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 681288000846 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 681288000847 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 681288000848 putative active site [active] 681288000849 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 681288000850 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 681288000851 putative active site cavity [active] 681288000852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 681288000853 Nucleoside recognition; Region: Gate; pfam07670 681288000854 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 681288000855 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 681288000856 PGAP1-like protein; Region: PGAP1; pfam07819 681288000857 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 681288000858 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 681288000859 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 681288000860 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 681288000861 putative active site [active] 681288000862 putative FMN binding site [chemical binding]; other site 681288000863 putative substrate binding site [chemical binding]; other site 681288000864 putative catalytic residue [active] 681288000865 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 681288000866 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 681288000867 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 681288000868 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 681288000869 lipoyl attachment site [posttranslational modification]; other site 681288000870 Replication protein C N-terminal domain; Region: RP-C; pfam03428 681288000871 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 681288000872 putative ADP-ribose binding site [chemical binding]; other site 681288000873 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 681288000874 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 681288000875 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 681288000876 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 681288000877 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 681288000878 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 681288000879 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 681288000880 NADP binding site [chemical binding]; other site 681288000881 putative substrate binding site [chemical binding]; other site 681288000882 active site 681288000883 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 681288000884 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 681288000885 active site 681288000886 P-loop; other site 681288000887 phosphorylation site [posttranslational modification] 681288000888 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288000889 active site 681288000890 phosphorylation site [posttranslational modification] 681288000891 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 681288000892 HTH domain; Region: HTH_11; pfam08279 681288000893 HTH domain; Region: HTH_11; pfam08279 681288000894 PRD domain; Region: PRD; pfam00874 681288000895 PRD domain; Region: PRD; pfam00874 681288000896 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 681288000897 active site 681288000898 P-loop; other site 681288000899 phosphorylation site [posttranslational modification] 681288000900 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288000901 active site 681288000902 phosphorylation site [posttranslational modification] 681288000903 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288000904 MarR family; Region: MarR_2; pfam12802 681288000905 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 681288000906 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 681288000907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 681288000908 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 681288000909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000910 putative substrate translocation pore; other site 681288000911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000912 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 681288000913 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 681288000914 Zn binding site [ion binding]; other site 681288000915 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 681288000916 Zn binding site [ion binding]; other site 681288000917 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 681288000918 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 681288000919 Predicted flavoprotein [General function prediction only]; Region: COG0431 681288000920 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 681288000921 Predicted membrane protein [Function unknown]; Region: COG2855 681288000922 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 681288000923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 681288000924 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 681288000925 Imelysin; Region: Peptidase_M75; pfam09375 681288000926 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 681288000927 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 681288000928 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 681288000929 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 681288000930 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 681288000931 Phage envelope protein [General function prediction only]; Region: COG5562 681288000932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288000933 non-specific DNA binding site [nucleotide binding]; other site 681288000934 salt bridge; other site 681288000935 sequence-specific DNA binding site [nucleotide binding]; other site 681288000936 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 681288000937 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 681288000938 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 681288000939 Walker A/P-loop; other site 681288000940 ATP binding site [chemical binding]; other site 681288000941 Q-loop/lid; other site 681288000942 ABC transporter signature motif; other site 681288000943 Walker B; other site 681288000944 D-loop; other site 681288000945 H-loop/switch region; other site 681288000946 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 681288000947 Predicted membrane protein [Function unknown]; Region: COG4292 681288000948 putative acyltransferase; Provisional; Region: PRK05790 681288000949 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 681288000950 dimer interface [polypeptide binding]; other site 681288000951 active site 681288000952 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 681288000953 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 681288000954 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 681288000955 THF binding site; other site 681288000956 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 681288000957 substrate binding site [chemical binding]; other site 681288000958 THF binding site; other site 681288000959 zinc-binding site [ion binding]; other site 681288000960 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 681288000961 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 681288000962 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 681288000963 FAD binding site [chemical binding]; other site 681288000964 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 681288000965 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 681288000966 homodimer interface [polypeptide binding]; other site 681288000967 substrate-cofactor binding pocket; other site 681288000968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288000969 catalytic residue [active] 681288000970 cystathionine gamma-synthase; Reviewed; Region: PRK08247 681288000971 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288000972 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288000973 catalytic residue [active] 681288000974 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 681288000975 ParB-like nuclease domain; Region: ParB; smart00470 681288000976 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 681288000977 Mechanosensitive ion channel; Region: MS_channel; pfam00924 681288000978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 681288000979 GTP-binding protein YchF; Reviewed; Region: PRK09601 681288000980 YchF GTPase; Region: YchF; cd01900 681288000981 G1 box; other site 681288000982 GTP/Mg2+ binding site [chemical binding]; other site 681288000983 Switch I region; other site 681288000984 G2 box; other site 681288000985 Switch II region; other site 681288000986 G3 box; other site 681288000987 G4 box; other site 681288000988 G5 box; other site 681288000989 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 681288000990 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 681288000991 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 681288000992 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 681288000993 dimer interface [polypeptide binding]; other site 681288000994 ssDNA binding site [nucleotide binding]; other site 681288000995 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288000996 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 681288000997 Abi-like protein; Region: Abi_2; pfam07751 681288000998 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 681288000999 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 681288001001 Predicted membrane protein [Function unknown]; Region: COG3212 681288001002 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 681288001003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 681288001004 non-specific DNA binding site [nucleotide binding]; other site 681288001005 salt bridge; other site 681288001006 sequence-specific DNA binding site [nucleotide binding]; other site 681288001007 Predicted membrane protein [Function unknown]; Region: COG2261 681288001008 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 681288001009 catalytic core [active] 681288001010 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 681288001011 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 681288001012 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 681288001013 catalytic residue [active] 681288001014 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 681288001015 catalytic residues [active] 681288001016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 681288001017 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288001018 peroxiredoxin; Region: AhpC; TIGR03137 681288001019 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 681288001020 dimer interface [polypeptide binding]; other site 681288001021 decamer (pentamer of dimers) interface [polypeptide binding]; other site 681288001022 catalytic triad [active] 681288001023 peroxidatic and resolving cysteines [active] 681288001024 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 681288001025 dimer interface [polypeptide binding]; other site 681288001026 FMN binding site [chemical binding]; other site 681288001027 NADPH bind site [chemical binding]; other site 681288001028 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 681288001029 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 681288001031 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288001032 active site 681288001033 xanthine permease; Region: pbuX; TIGR03173 681288001034 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 681288001035 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 681288001036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 681288001037 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 681288001038 active site 681288001039 GMP synthase; Reviewed; Region: guaA; PRK00074 681288001040 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 681288001041 AMP/PPi binding site [chemical binding]; other site 681288001042 candidate oxyanion hole; other site 681288001043 catalytic triad [active] 681288001044 potential glutamine specificity residues [chemical binding]; other site 681288001045 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 681288001046 ATP Binding subdomain [chemical binding]; other site 681288001047 Ligand Binding sites [chemical binding]; other site 681288001048 Dimerization subdomain; other site 681288001049 PemK-like protein; Region: PemK; pfam02452 681288001050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 681288001051 Transposase; Region: HTH_Tnp_1; cl17663 681288001052 Predicted membrane protein [Function unknown]; Region: COG3759 681288001053 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 681288001054 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 681288001055 NADP binding site [chemical binding]; other site 681288001056 superantigen-like protein; Reviewed; Region: PRK13037 681288001057 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001058 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001059 superantigen-like protein; Reviewed; Region: PRK13041 681288001060 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001061 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001062 superantigen-like protein; Reviewed; Region: PRK13335 681288001063 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001064 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001065 superantigen-like protein; Reviewed; Region: PRK13042 681288001066 Mucin-like glycoprotein; Region: Mucin; pfam01456 681288001067 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001068 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001069 superantigen-like protein 5; Reviewed; Region: PRK13035 681288001070 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001071 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001072 superantigen-like protein 7; Reviewed; Region: PRK13346 681288001073 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001074 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001075 superantigen-like protein; Reviewed; Region: PRK13039 681288001076 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001077 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001078 superantigen-like protein; Reviewed; Region: PRK13345 681288001079 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001080 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001081 superantigen-like protein 5; Reviewed; Region: PRK13035 681288001082 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001083 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001084 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 681288001085 HsdM N-terminal domain; Region: HsdM_N; pfam12161 681288001086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288001087 S-adenosylmethionine binding site [chemical binding]; other site 681288001088 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 681288001089 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 681288001090 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 681288001091 superantigen-like protein; Reviewed; Region: PRK13036 681288001092 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001093 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001094 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288001095 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288001096 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288001097 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288001098 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288001099 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288001100 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288001101 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288001102 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288001103 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288001104 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 681288001105 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 681288001106 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 681288001107 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 681288001108 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 681288001109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 681288001110 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 681288001111 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 681288001112 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 681288001113 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 681288001114 active site 681288001115 Esterase/lipase [General function prediction only]; Region: COG1647 681288001116 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 681288001117 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 681288001118 Na2 binding site [ion binding]; other site 681288001119 putative substrate binding site 1 [chemical binding]; other site 681288001120 Na binding site 1 [ion binding]; other site 681288001121 putative substrate binding site 2 [chemical binding]; other site 681288001122 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 681288001123 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 681288001124 dimer interface [polypeptide binding]; other site 681288001125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001126 catalytic residue [active] 681288001127 cystathionine beta-lyase; Provisional; Region: PRK07671 681288001128 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 681288001129 homodimer interface [polypeptide binding]; other site 681288001130 substrate-cofactor binding pocket; other site 681288001131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001132 catalytic residue [active] 681288001133 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 681288001134 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 681288001135 Walker A/P-loop; other site 681288001136 ATP binding site [chemical binding]; other site 681288001137 Q-loop/lid; other site 681288001138 ABC transporter signature motif; other site 681288001139 Walker B; other site 681288001140 D-loop; other site 681288001141 H-loop/switch region; other site 681288001142 NIL domain; Region: NIL; pfam09383 681288001143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288001144 dimer interface [polypeptide binding]; other site 681288001145 conserved gate region; other site 681288001146 ABC-ATPase subunit interface; other site 681288001147 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 681288001148 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 681288001149 LysM domain; Region: LysM; pfam01476 681288001150 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 681288001151 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 681288001152 Surface antigen [General function prediction only]; Region: COG3942 681288001153 CHAP domain; Region: CHAP; pfam05257 681288001154 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 681288001155 nudix motif; other site 681288001156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288001157 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 681288001158 Coenzyme A binding pocket [chemical binding]; other site 681288001159 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 681288001160 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 681288001161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 681288001162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 681288001163 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 681288001164 dimerization interface [polypeptide binding]; other site 681288001165 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 681288001166 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 681288001167 active site 681288001168 dimer interface [polypeptide binding]; other site 681288001169 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 681288001170 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 681288001171 active site 681288001172 FMN binding site [chemical binding]; other site 681288001173 substrate binding site [chemical binding]; other site 681288001174 3Fe-4S cluster binding site [ion binding]; other site 681288001175 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 681288001176 domain interface; other site 681288001177 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 681288001178 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 681288001179 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 681288001180 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288001181 active site turn [active] 681288001182 phosphorylation site [posttranslational modification] 681288001183 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 681288001184 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 681288001185 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 681288001186 Ca binding site [ion binding]; other site 681288001187 active site 681288001188 catalytic site [active] 681288001189 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 681288001190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288001191 DNA-binding site [nucleotide binding]; DNA binding site 681288001192 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 681288001193 UTRA domain; Region: UTRA; pfam07702 681288001194 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 681288001195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288001196 Coenzyme A binding pocket [chemical binding]; other site 681288001197 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 681288001198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288001199 Walker A motif; other site 681288001200 ATP binding site [chemical binding]; other site 681288001201 Walker B motif; other site 681288001202 arginine finger; other site 681288001203 hypothetical protein; Validated; Region: PRK00153 681288001204 recombination protein RecR; Reviewed; Region: recR; PRK00076 681288001205 RecR protein; Region: RecR; pfam02132 681288001206 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 681288001207 putative active site [active] 681288001208 putative metal-binding site [ion binding]; other site 681288001209 tetramer interface [polypeptide binding]; other site 681288001210 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 681288001211 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288001212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288001213 catalytic residue [active] 681288001214 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 681288001215 thymidylate kinase; Validated; Region: tmk; PRK00698 681288001216 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 681288001217 TMP-binding site; other site 681288001218 ATP-binding site [chemical binding]; other site 681288001219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 681288001220 DNA polymerase III subunit delta'; Validated; Region: PRK08058 681288001221 DNA polymerase III subunit delta'; Validated; Region: PRK08485 681288001222 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 681288001223 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 681288001224 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 681288001225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288001226 S-adenosylmethionine binding site [chemical binding]; other site 681288001227 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 681288001228 GIY-YIG motif/motif A; other site 681288001229 putative active site [active] 681288001230 putative metal binding site [ion binding]; other site 681288001231 Predicted methyltransferases [General function prediction only]; Region: COG0313 681288001232 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 681288001233 putative SAM binding site [chemical binding]; other site 681288001234 putative homodimer interface [polypeptide binding]; other site 681288001235 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 681288001236 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 681288001237 active site 681288001238 HIGH motif; other site 681288001239 KMSKS motif; other site 681288001240 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 681288001241 tRNA binding surface [nucleotide binding]; other site 681288001242 anticodon binding site; other site 681288001243 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 681288001244 dimer interface [polypeptide binding]; other site 681288001245 putative tRNA-binding site [nucleotide binding]; other site 681288001246 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 681288001247 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 681288001248 active site 681288001249 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 681288001250 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 681288001251 putative active site [active] 681288001252 putative metal binding site [ion binding]; other site 681288001253 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 681288001254 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 681288001255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288001256 S-adenosylmethionine binding site [chemical binding]; other site 681288001257 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 681288001258 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 681288001259 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 681288001260 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 681288001261 pur operon repressor; Provisional; Region: PRK09213 681288001262 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 681288001263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288001264 active site 681288001265 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 681288001266 homotrimer interaction site [polypeptide binding]; other site 681288001267 putative active site [active] 681288001268 regulatory protein SpoVG; Reviewed; Region: PRK13259 681288001269 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 681288001270 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 681288001271 Substrate binding site; other site 681288001272 Mg++ binding site; other site 681288001273 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 681288001274 active site 681288001275 substrate binding site [chemical binding]; other site 681288001276 CoA binding site [chemical binding]; other site 681288001277 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 681288001278 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 681288001279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288001280 active site 681288001281 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 681288001282 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 681288001283 5S rRNA interface [nucleotide binding]; other site 681288001284 CTC domain interface [polypeptide binding]; other site 681288001285 L16 interface [polypeptide binding]; other site 681288001286 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 681288001287 putative active site [active] 681288001288 catalytic residue [active] 681288001289 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 681288001290 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 681288001291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288001292 ATP binding site [chemical binding]; other site 681288001293 putative Mg++ binding site [ion binding]; other site 681288001294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288001295 nucleotide binding region [chemical binding]; other site 681288001296 ATP-binding site [chemical binding]; other site 681288001297 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 681288001298 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 681288001299 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 681288001300 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 681288001301 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 681288001302 putative SAM binding site [chemical binding]; other site 681288001303 putative homodimer interface [polypeptide binding]; other site 681288001304 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 681288001305 homodimer interface [polypeptide binding]; other site 681288001306 metal binding site [ion binding]; metal-binding site 681288001307 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288001308 RNA binding surface [nucleotide binding]; other site 681288001309 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 681288001310 Septum formation initiator; Region: DivIC; pfam04977 681288001311 hypothetical protein; Provisional; Region: PRK08582 681288001312 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 681288001313 RNA binding site [nucleotide binding]; other site 681288001314 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 681288001315 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 681288001316 Ligand Binding Site [chemical binding]; other site 681288001317 TilS substrate C-terminal domain; Region: TilS_C; smart00977 681288001318 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 681288001319 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288001320 active site 681288001321 FtsH Extracellular; Region: FtsH_ext; pfam06480 681288001322 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 681288001323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288001324 Walker A motif; other site 681288001325 ATP binding site [chemical binding]; other site 681288001326 Walker B motif; other site 681288001327 arginine finger; other site 681288001328 Peptidase family M41; Region: Peptidase_M41; pfam01434 681288001329 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 681288001330 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 681288001331 dimerization interface [polypeptide binding]; other site 681288001332 domain crossover interface; other site 681288001333 redox-dependent activation switch; other site 681288001334 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 681288001335 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 681288001336 dimer interface [polypeptide binding]; other site 681288001337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001338 catalytic residue [active] 681288001339 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 681288001340 dihydropteroate synthase; Region: DHPS; TIGR01496 681288001341 substrate binding pocket [chemical binding]; other site 681288001342 dimer interface [polypeptide binding]; other site 681288001343 inhibitor binding site; inhibition site 681288001344 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 681288001345 homooctamer interface [polypeptide binding]; other site 681288001346 active site 681288001347 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 681288001348 catalytic center binding site [active] 681288001349 ATP binding site [chemical binding]; other site 681288001350 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 681288001351 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 681288001352 dimer interface [polypeptide binding]; other site 681288001353 putative anticodon binding site; other site 681288001354 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 681288001355 motif 1; other site 681288001356 active site 681288001357 motif 2; other site 681288001358 motif 3; other site 681288001359 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 681288001360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288001361 DNA-binding site [nucleotide binding]; DNA binding site 681288001362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288001363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001364 homodimer interface [polypeptide binding]; other site 681288001365 catalytic residue [active] 681288001366 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 681288001367 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 681288001368 active site 681288001369 multimer interface [polypeptide binding]; other site 681288001370 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 681288001371 predicted active site [active] 681288001372 catalytic triad [active] 681288001373 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 681288001374 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 681288001375 Nucleoside recognition; Region: Gate; pfam07670 681288001376 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 681288001377 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 681288001378 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 681288001379 UvrB/uvrC motif; Region: UVR; pfam02151 681288001380 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 681288001381 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 681288001382 ADP binding site [chemical binding]; other site 681288001383 phosphagen binding site; other site 681288001384 substrate specificity loop; other site 681288001385 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 681288001386 Clp amino terminal domain; Region: Clp_N; pfam02861 681288001387 Clp amino terminal domain; Region: Clp_N; pfam02861 681288001388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288001389 Walker A motif; other site 681288001390 ATP binding site [chemical binding]; other site 681288001391 Walker B motif; other site 681288001392 arginine finger; other site 681288001393 UvrB/uvrC motif; Region: UVR; pfam02151 681288001394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288001395 Walker A motif; other site 681288001396 ATP binding site [chemical binding]; other site 681288001397 Walker B motif; other site 681288001398 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 681288001399 DNA repair protein RadA; Provisional; Region: PRK11823 681288001400 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 681288001401 Walker A motif/ATP binding site; other site 681288001402 ATP binding site [chemical binding]; other site 681288001403 Walker B motif; other site 681288001404 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 681288001405 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 681288001406 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 681288001407 putative active site [active] 681288001408 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 681288001409 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 681288001410 active site 681288001411 HIGH motif; other site 681288001412 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 681288001413 active site 681288001414 KMSKS motif; other site 681288001415 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 681288001416 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 681288001417 trimer interface [polypeptide binding]; other site 681288001418 active site 681288001419 substrate binding site [chemical binding]; other site 681288001420 CoA binding site [chemical binding]; other site 681288001421 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 681288001422 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 681288001423 active site 681288001424 HIGH motif; other site 681288001425 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 681288001426 KMSKS motif; other site 681288001427 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 681288001428 tRNA binding surface [nucleotide binding]; other site 681288001429 anticodon binding site; other site 681288001430 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 681288001431 active site 681288001432 dimerization interface [polypeptide binding]; other site 681288001433 metal binding site [ion binding]; metal-binding site 681288001434 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 681288001435 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 681288001436 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 681288001437 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 681288001438 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 681288001439 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 681288001440 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 681288001441 DNA binding residues [nucleotide binding] 681288001442 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 681288001443 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 681288001444 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 681288001445 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 681288001446 putative homodimer interface [polypeptide binding]; other site 681288001447 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 681288001448 heterodimer interface [polypeptide binding]; other site 681288001449 homodimer interface [polypeptide binding]; other site 681288001450 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 681288001451 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 681288001452 23S rRNA interface [nucleotide binding]; other site 681288001453 L7/L12 interface [polypeptide binding]; other site 681288001454 putative thiostrepton binding site; other site 681288001455 L25 interface [polypeptide binding]; other site 681288001456 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 681288001457 mRNA/rRNA interface [nucleotide binding]; other site 681288001458 SAAV_0501 681288001459 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 681288001460 23S rRNA interface [nucleotide binding]; other site 681288001461 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 681288001462 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 681288001463 peripheral dimer interface [polypeptide binding]; other site 681288001464 core dimer interface [polypeptide binding]; other site 681288001465 L10 interface [polypeptide binding]; other site 681288001466 L11 interface [polypeptide binding]; other site 681288001467 putative EF-Tu interaction site [polypeptide binding]; other site 681288001468 putative EF-G interaction site [polypeptide binding]; other site 681288001469 Methyltransferase domain; Region: Methyltransf_31; pfam13847 681288001470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288001471 S-adenosylmethionine binding site [chemical binding]; other site 681288001472 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 681288001473 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 681288001474 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 681288001475 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 681288001476 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 681288001477 RPB10 interaction site [polypeptide binding]; other site 681288001478 RPB1 interaction site [polypeptide binding]; other site 681288001479 RPB11 interaction site [polypeptide binding]; other site 681288001480 RPB3 interaction site [polypeptide binding]; other site 681288001481 RPB12 interaction site [polypeptide binding]; other site 681288001482 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 681288001483 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 681288001484 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 681288001485 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 681288001486 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 681288001487 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 681288001488 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 681288001489 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 681288001490 G-loop; other site 681288001491 DNA binding site [nucleotide binding] 681288001492 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 681288001493 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 681288001494 S17 interaction site [polypeptide binding]; other site 681288001495 S8 interaction site; other site 681288001496 16S rRNA interaction site [nucleotide binding]; other site 681288001497 streptomycin interaction site [chemical binding]; other site 681288001498 23S rRNA interaction site [nucleotide binding]; other site 681288001499 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 681288001500 30S ribosomal protein S7; Validated; Region: PRK05302 681288001501 elongation factor G; Reviewed; Region: PRK00007 681288001502 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 681288001503 G1 box; other site 681288001504 putative GEF interaction site [polypeptide binding]; other site 681288001505 GTP/Mg2+ binding site [chemical binding]; other site 681288001506 Switch I region; other site 681288001507 G2 box; other site 681288001508 G3 box; other site 681288001509 Switch II region; other site 681288001510 G4 box; other site 681288001511 G5 box; other site 681288001512 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 681288001513 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 681288001514 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 681288001515 elongation factor Tu; Reviewed; Region: PRK00049 681288001516 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 681288001517 G1 box; other site 681288001518 GEF interaction site [polypeptide binding]; other site 681288001519 GTP/Mg2+ binding site [chemical binding]; other site 681288001520 Switch I region; other site 681288001521 G2 box; other site 681288001522 G3 box; other site 681288001523 Switch II region; other site 681288001524 G4 box; other site 681288001525 G5 box; other site 681288001526 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 681288001527 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 681288001528 Antibiotic Binding Site [chemical binding]; other site 681288001529 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 681288001530 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 681288001531 metal binding site [ion binding]; metal-binding site 681288001532 dimer interface [polypeptide binding]; other site 681288001533 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 681288001534 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 681288001535 substrate-cofactor binding pocket; other site 681288001536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001537 catalytic residue [active] 681288001538 chaperone protein HchA; Provisional; Region: PRK04155 681288001539 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 681288001540 dimer interface [polypeptide binding]; other site 681288001541 metal binding site [ion binding]; metal-binding site 681288001542 potential oxyanion hole; other site 681288001543 potential catalytic triad [active] 681288001544 conserved cys residue [active] 681288001545 ribulokinase; Provisional; Region: PRK04123 681288001546 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 681288001547 N- and C-terminal domain interface [polypeptide binding]; other site 681288001548 active site 681288001549 MgATP binding site [chemical binding]; other site 681288001550 catalytic site [active] 681288001551 metal binding site [ion binding]; metal-binding site 681288001552 carbohydrate binding site [chemical binding]; other site 681288001553 homodimer interface [polypeptide binding]; other site 681288001554 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 681288001555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288001556 NAD(P) binding site [chemical binding]; other site 681288001557 active site 681288001558 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 681288001559 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 681288001560 homodimer interface [polypeptide binding]; other site 681288001561 substrate-cofactor binding pocket; other site 681288001562 catalytic residue [active] 681288001563 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 681288001564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288001565 motif II; other site 681288001566 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 681288001567 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 681288001568 Substrate-binding site [chemical binding]; other site 681288001569 Substrate specificity [chemical binding]; other site 681288001570 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 681288001571 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 681288001572 Substrate-binding site [chemical binding]; other site 681288001573 Substrate specificity [chemical binding]; other site 681288001574 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 681288001575 nucleoside/Zn binding site; other site 681288001576 dimer interface [polypeptide binding]; other site 681288001577 catalytic motif [active] 681288001578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288001579 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 681288001580 active site 681288001581 motif I; other site 681288001582 motif II; other site 681288001583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288001584 Predicted flavoprotein [General function prediction only]; Region: COG0431 681288001585 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 681288001586 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 681288001587 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288001588 Cna protein B-type domain; Region: Cna_B; pfam05738 681288001589 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 681288001590 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 681288001591 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288001592 Cna protein B-type domain; Region: Cna_B; pfam05738 681288001593 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 681288001594 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 681288001595 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 681288001596 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 681288001597 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 681288001598 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288001599 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 681288001600 Cna protein B-type domain; Region: Cna_B; pfam05738 681288001601 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 681288001602 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 681288001603 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 681288001604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 681288001605 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 681288001606 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 681288001607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 681288001608 putative GTP cyclohydrolase; Provisional; Region: PRK13674 681288001609 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 681288001610 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 681288001611 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 681288001612 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 681288001613 active site 681288001614 trimer interface [polypeptide binding]; other site 681288001615 allosteric site; other site 681288001616 active site lid [active] 681288001617 hexamer (dimer of trimers) interface [polypeptide binding]; other site 681288001618 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 681288001619 active site 681288001620 dimer interface [polypeptide binding]; other site 681288001621 magnesium binding site [ion binding]; other site 681288001622 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 681288001623 tetramer interface [polypeptide binding]; other site 681288001624 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 681288001625 active site 681288001626 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 681288001627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288001628 motif II; other site 681288001629 proline/glycine betaine transporter; Provisional; Region: PRK10642 681288001630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288001631 putative substrate translocation pore; other site 681288001632 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 681288001633 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 681288001634 acyl-activating enzyme (AAE) consensus motif; other site 681288001635 AMP binding site [chemical binding]; other site 681288001636 active site 681288001637 CoA binding site [chemical binding]; other site 681288001638 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 681288001639 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 681288001640 dimer interface [polypeptide binding]; other site 681288001641 active site 681288001642 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 681288001643 dimer interface [polypeptide binding]; other site 681288001644 substrate binding site [chemical binding]; other site 681288001645 ATP binding site [chemical binding]; other site 681288001646 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 681288001647 ligand binding site [chemical binding]; other site 681288001648 active site 681288001649 UGI interface [polypeptide binding]; other site 681288001650 catalytic site [active] 681288001651 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 681288001652 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 681288001653 Uncharacterized conserved protein [Function unknown]; Region: COG3610 681288001654 Uncharacterized conserved protein [Function unknown]; Region: COG2966 681288001655 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 681288001656 putative heme peroxidase; Provisional; Region: PRK12276 681288001657 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 681288001658 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 681288001659 mevalonate kinase; Region: mevalon_kin; TIGR00549 681288001660 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 681288001661 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 681288001662 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 681288001663 diphosphomevalonate decarboxylase; Region: PLN02407 681288001664 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 681288001665 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 681288001666 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 681288001667 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 681288001668 Predicted transcriptional regulator [Transcription]; Region: COG1959 681288001669 Transcriptional regulator; Region: Rrf2; pfam02082 681288001670 LXG domain of WXG superfamily; Region: LXG; pfam04740 681288001671 Protein of unknown function (DUF443); Region: DUF443; pfam04276 681288001672 Protein of unknown function (DUF443); Region: DUF443; pfam04276 681288001673 Protein of unknown function (DUF443); Region: DUF443; pfam04276 681288001674 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288001675 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 681288001676 active site 681288001677 catalytic tetrad [active] 681288001678 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 681288001679 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 681288001680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 681288001681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288001682 Coenzyme A binding pocket [chemical binding]; other site 681288001683 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 681288001684 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 681288001685 Zn2+ binding site [ion binding]; other site 681288001686 Mg2+ binding site [ion binding]; other site 681288001687 YwhD family; Region: YwhD; pfam08741 681288001688 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 681288001689 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 681288001690 NAD binding site [chemical binding]; other site 681288001691 substrate binding site [chemical binding]; other site 681288001692 catalytic Zn binding site [ion binding]; other site 681288001693 tetramer interface [polypeptide binding]; other site 681288001694 structural Zn binding site [ion binding]; other site 681288001695 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 681288001696 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 681288001697 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 681288001698 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 681288001699 active site 681288001700 HIGH motif; other site 681288001701 KMSK motif region; other site 681288001702 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 681288001703 tRNA binding surface [nucleotide binding]; other site 681288001704 anticodon binding site; other site 681288001705 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 681288001706 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 681288001707 minor groove reading motif; other site 681288001708 helix-hairpin-helix signature motif; other site 681288001709 substrate binding pocket [chemical binding]; other site 681288001710 active site 681288001711 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 681288001712 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 681288001713 putative binding site residues; other site 681288001714 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288001715 ABC-ATPase subunit interface; other site 681288001716 dimer interface [polypeptide binding]; other site 681288001717 putative PBP binding regions; other site 681288001718 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 681288001719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288001720 motif II; other site 681288001721 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 681288001722 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 681288001723 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 681288001724 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 681288001725 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288001726 Transcriptional regulators [Transcription]; Region: MarR; COG1846 681288001727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 681288001728 Protein of unknown function, DUF606; Region: DUF606; pfam04657 681288001729 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 681288001730 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 681288001731 active site 681288001732 DNA binding site [nucleotide binding] 681288001733 Int/Topo IB signature motif; other site 681288001734 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 681288001735 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 681288001736 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 681288001737 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 681288001738 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 681288001739 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 681288001740 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 681288001741 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 681288001742 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 681288001743 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 681288001744 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 681288001745 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 681288001746 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 681288001747 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 681288001748 metal binding site [ion binding]; metal-binding site 681288001749 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 681288001750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288001751 ABC-ATPase subunit interface; other site 681288001752 dimer interface [polypeptide binding]; other site 681288001753 putative PBP binding regions; other site 681288001754 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 681288001755 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 681288001756 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 681288001757 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 681288001758 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 681288001759 FeoA domain; Region: FeoA; pfam04023 681288001760 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 681288001761 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 681288001762 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 681288001763 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 681288001764 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 681288001765 Walker A/P-loop; other site 681288001766 ATP binding site [chemical binding]; other site 681288001767 Q-loop/lid; other site 681288001768 ABC transporter signature motif; other site 681288001769 Walker B; other site 681288001770 D-loop; other site 681288001771 H-loop/switch region; other site 681288001772 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 681288001773 ABC-2 type transporter; Region: ABC2_membrane; cl17235 681288001774 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 681288001775 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 681288001776 active site 681288001777 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 681288001778 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 681288001779 active site 681288001780 nucleotide binding site [chemical binding]; other site 681288001781 HIGH motif; other site 681288001782 KMSKS motif; other site 681288001783 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 681288001784 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 681288001785 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 681288001786 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 681288001787 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 681288001788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288001789 Walker A/P-loop; other site 681288001790 ATP binding site [chemical binding]; other site 681288001791 Q-loop/lid; other site 681288001792 ABC transporter signature motif; other site 681288001793 Walker B; other site 681288001794 D-loop; other site 681288001795 H-loop/switch region; other site 681288001796 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 681288001797 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 681288001798 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 681288001799 Uncharacterized conserved protein [Function unknown]; Region: COG1284 681288001800 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 681288001801 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 681288001802 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 681288001803 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 681288001804 Walker A/P-loop; other site 681288001805 ATP binding site [chemical binding]; other site 681288001806 Q-loop/lid; other site 681288001807 ABC transporter signature motif; other site 681288001808 Walker B; other site 681288001809 D-loop; other site 681288001810 H-loop/switch region; other site 681288001811 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 681288001812 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288001813 ABC-ATPase subunit interface; other site 681288001814 dimer interface [polypeptide binding]; other site 681288001815 putative PBP binding regions; other site 681288001816 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 681288001817 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288001818 ABC-ATPase subunit interface; other site 681288001819 dimer interface [polypeptide binding]; other site 681288001820 putative PBP binding regions; other site 681288001821 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 681288001822 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 681288001823 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 681288001824 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 681288001825 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 681288001826 Uncharacterized membrane protein [Function unknown]; Region: COG3949 681288001827 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 681288001828 Na binding site [ion binding]; other site 681288001829 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 681288001830 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 681288001831 substrate binding pocket [chemical binding]; other site 681288001832 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 681288001833 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 681288001834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288001835 Coenzyme A binding pocket [chemical binding]; other site 681288001836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 681288001837 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 681288001838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288001839 NAD(P) binding site [chemical binding]; other site 681288001840 active site 681288001841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288001842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288001843 active site 681288001844 phosphorylation site [posttranslational modification] 681288001845 intermolecular recognition site; other site 681288001846 dimerization interface [polypeptide binding]; other site 681288001847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288001848 DNA binding site [nucleotide binding] 681288001849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 681288001850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 681288001851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288001852 ATP binding site [chemical binding]; other site 681288001853 Mg2+ binding site [ion binding]; other site 681288001854 G-X-G motif; other site 681288001855 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288001856 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 681288001857 Walker A/P-loop; other site 681288001858 ATP binding site [chemical binding]; other site 681288001859 Q-loop/lid; other site 681288001860 ABC transporter signature motif; other site 681288001861 Walker B; other site 681288001862 D-loop; other site 681288001863 H-loop/switch region; other site 681288001864 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 681288001865 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 681288001866 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 681288001867 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 681288001868 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 681288001869 Surface antigen [General function prediction only]; Region: COG3942 681288001870 CHAP domain; Region: CHAP; pfam05257 681288001871 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 681288001872 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 681288001873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 681288001874 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288001875 hypothetical protein; Provisional; Region: PRK12378 681288001876 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 681288001877 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 681288001878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 681288001879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 681288001880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 681288001881 dimerization interface [polypeptide binding]; other site 681288001882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288001883 sugar efflux transporter; Region: 2A0120; TIGR00899 681288001884 putative substrate translocation pore; other site 681288001885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 681288001886 Serine incorporator (Serinc); Region: Serinc; pfam03348 681288001887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288001888 Coenzyme A binding pocket [chemical binding]; other site 681288001889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 681288001890 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 681288001891 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 681288001892 hypothetical protein; Validated; Region: PRK00124 681288001893 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 681288001894 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 681288001895 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 681288001896 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 681288001897 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 681288001898 Walker A/P-loop; other site 681288001899 ATP binding site [chemical binding]; other site 681288001900 Q-loop/lid; other site 681288001901 ABC transporter signature motif; other site 681288001902 Walker B; other site 681288001903 D-loop; other site 681288001904 H-loop/switch region; other site 681288001905 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 681288001906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 681288001907 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 681288001908 Walker A/P-loop; other site 681288001909 ATP binding site [chemical binding]; other site 681288001910 Q-loop/lid; other site 681288001911 ABC transporter signature motif; other site 681288001912 Walker B; other site 681288001913 D-loop; other site 681288001914 H-loop/switch region; other site 681288001915 Transcriptional regulators [Transcription]; Region: MarR; COG1846 681288001916 MarR family; Region: MarR; pfam01047 681288001917 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 681288001918 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 681288001919 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 681288001920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288001921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 681288001922 active site 681288001923 catalytic tetrad [active] 681288001924 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 681288001925 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 681288001926 transmembrane helices; other site 681288001927 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 681288001928 DNA photolyase; Region: DNA_photolyase; pfam00875 681288001929 Predicted membrane protein [Function unknown]; Region: COG4330 681288001930 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 681288001931 trimer interface [polypeptide binding]; other site 681288001932 putative Zn binding site [ion binding]; other site 681288001933 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 681288001934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288001935 putative substrate translocation pore; other site 681288001936 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 681288001937 putative deacylase active site [active] 681288001938 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 681288001939 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 681288001940 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 681288001941 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 681288001942 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 681288001943 putative substrate binding site [chemical binding]; other site 681288001944 putative ATP binding site [chemical binding]; other site 681288001945 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 681288001946 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288001947 active site 681288001948 phosphorylation site [posttranslational modification] 681288001949 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 681288001950 active site 681288001951 P-loop; other site 681288001952 phosphorylation site [posttranslational modification] 681288001953 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 681288001954 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 681288001955 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 681288001956 active site 681288001957 dimer interface [polypeptide binding]; other site 681288001958 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 681288001959 Domain of unknown function DUF21; Region: DUF21; pfam01595 681288001960 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 681288001961 Transporter associated domain; Region: CorC_HlyC; pfam03471 681288001962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288001963 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 681288001964 active site 681288001965 catalytic tetrad [active] 681288001966 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 681288001967 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 681288001968 Ligand binding site; other site 681288001969 Putative Catalytic site; other site 681288001970 DXD motif; other site 681288001971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 681288001972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288001973 dimer interface [polypeptide binding]; other site 681288001974 phosphorylation site [posttranslational modification] 681288001975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288001976 ATP binding site [chemical binding]; other site 681288001977 Mg2+ binding site [ion binding]; other site 681288001978 G-X-G motif; other site 681288001979 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288001980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288001981 active site 681288001982 phosphorylation site [posttranslational modification] 681288001983 intermolecular recognition site; other site 681288001984 dimerization interface [polypeptide binding]; other site 681288001985 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288001986 DNA binding site [nucleotide binding] 681288001987 DoxX; Region: DoxX; pfam07681 681288001988 Electron transfer DM13; Region: DM13; pfam10517 681288001989 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 681288001990 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 681288001991 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 681288001992 active site 681288001993 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 681288001994 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 681288001995 Ligand Binding Site [chemical binding]; other site 681288001996 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 681288001997 Glutamine amidotransferase class-I; Region: GATase; pfam00117 681288001998 glutamine binding [chemical binding]; other site 681288001999 catalytic triad [active] 681288002000 aminodeoxychorismate synthase; Provisional; Region: PRK07508 681288002001 chorismate binding enzyme; Region: Chorismate_bind; cl10555 681288002002 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 681288002003 substrate-cofactor binding pocket; other site 681288002004 Aminotransferase class IV; Region: Aminotran_4; pfam01063 681288002005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288002006 catalytic residue [active] 681288002007 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 681288002008 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 681288002009 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 681288002010 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 681288002011 Sulfatase; Region: Sulfatase; pfam00884 681288002012 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 681288002013 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 681288002014 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 681288002015 ABC transporter; Region: ABC_tran_2; pfam12848 681288002016 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 681288002017 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 681288002018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288002019 ATP binding site [chemical binding]; other site 681288002020 putative Mg++ binding site [ion binding]; other site 681288002021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288002022 nucleotide binding region [chemical binding]; other site 681288002023 ATP-binding site [chemical binding]; other site 681288002024 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 681288002025 HRDC domain; Region: HRDC; pfam00570 681288002026 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 681288002027 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 681288002028 Walker A/P-loop; other site 681288002029 ATP binding site [chemical binding]; other site 681288002030 Q-loop/lid; other site 681288002031 ABC transporter signature motif; other site 681288002032 Walker B; other site 681288002033 D-loop; other site 681288002034 H-loop/switch region; other site 681288002035 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 681288002036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002037 dimer interface [polypeptide binding]; other site 681288002038 conserved gate region; other site 681288002039 ABC-ATPase subunit interface; other site 681288002040 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 681288002041 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 681288002042 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 681288002043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288002044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288002045 homodimer interface [polypeptide binding]; other site 681288002046 catalytic residue [active] 681288002047 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 681288002048 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 681288002049 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 681288002050 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 681288002051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288002052 putative substrate translocation pore; other site 681288002053 POT family; Region: PTR2; cl17359 681288002054 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 681288002055 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 681288002056 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 681288002057 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 681288002058 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 681288002059 Class I ribonucleotide reductase; Region: RNR_I; cd01679 681288002060 active site 681288002061 dimer interface [polypeptide binding]; other site 681288002062 catalytic residues [active] 681288002063 effector binding site; other site 681288002064 R2 peptide binding site; other site 681288002065 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 681288002066 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 681288002067 dimer interface [polypeptide binding]; other site 681288002068 putative radical transfer pathway; other site 681288002069 diiron center [ion binding]; other site 681288002070 tyrosyl radical; other site 681288002071 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288002072 ABC-ATPase subunit interface; other site 681288002073 dimer interface [polypeptide binding]; other site 681288002074 putative PBP binding regions; other site 681288002075 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288002076 ABC-ATPase subunit interface; other site 681288002077 dimer interface [polypeptide binding]; other site 681288002078 putative PBP binding regions; other site 681288002079 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 681288002080 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 681288002081 Walker A/P-loop; other site 681288002082 ATP binding site [chemical binding]; other site 681288002083 Q-loop/lid; other site 681288002084 ABC transporter signature motif; other site 681288002085 Walker B; other site 681288002086 D-loop; other site 681288002087 H-loop/switch region; other site 681288002088 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 681288002089 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 681288002090 putative ligand binding residues [chemical binding]; other site 681288002091 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 681288002092 CHY zinc finger; Region: zf-CHY; pfam05495 681288002093 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 681288002094 FAD binding domain; Region: FAD_binding_4; pfam01565 681288002095 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 681288002096 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 681288002097 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 681288002098 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 681288002099 peptidase T; Region: peptidase-T; TIGR01882 681288002100 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 681288002101 metal binding site [ion binding]; metal-binding site 681288002102 dimer interface [polypeptide binding]; other site 681288002103 Uncharacterized conserved protein [Function unknown]; Region: COG3610 681288002104 Uncharacterized conserved protein [Function unknown]; Region: COG2966 681288002105 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 681288002106 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 681288002107 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 681288002108 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 681288002109 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 681288002110 metal binding site [ion binding]; metal-binding site 681288002111 active site 681288002112 I-site; other site 681288002113 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 681288002114 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 681288002115 Mg++ binding site [ion binding]; other site 681288002116 putative catalytic motif [active] 681288002117 substrate binding site [chemical binding]; other site 681288002118 Uncharacterized conserved protein [Function unknown]; Region: COG1739 681288002119 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 681288002120 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 681288002121 EDD domain protein, DegV family; Region: DegV; TIGR00762 681288002122 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 681288002123 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 681288002124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288002125 ATP binding site [chemical binding]; other site 681288002126 putative Mg++ binding site [ion binding]; other site 681288002127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288002128 nucleotide binding region [chemical binding]; other site 681288002129 ATP-binding site [chemical binding]; other site 681288002130 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 681288002131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288002132 active site 681288002133 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 681288002134 30S subunit binding site; other site 681288002135 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 681288002136 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 681288002137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 681288002138 nucleotide binding region [chemical binding]; other site 681288002139 ATP-binding site [chemical binding]; other site 681288002140 SEC-C motif; Region: SEC-C; pfam02810 681288002141 peptide chain release factor 2; Provisional; Region: PRK06746 681288002142 This domain is found in peptide chain release factors; Region: PCRF; smart00937 681288002143 RF-1 domain; Region: RF-1; pfam00472 681288002144 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 681288002145 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 681288002146 Surface antigen [General function prediction only]; Region: COG3942 681288002147 CHAP domain; Region: CHAP; pfam05257 681288002148 HD domain; Region: HD_3; cl17350 681288002149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 681288002150 excinuclease ABC subunit B; Provisional; Region: PRK05298 681288002151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288002152 ATP binding site [chemical binding]; other site 681288002153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288002154 nucleotide binding region [chemical binding]; other site 681288002155 ATP-binding site [chemical binding]; other site 681288002156 Ultra-violet resistance protein B; Region: UvrB; pfam12344 681288002157 UvrB/uvrC motif; Region: UVR; pfam02151 681288002158 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 681288002159 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 681288002160 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 681288002161 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 681288002162 HPr kinase/phosphorylase; Provisional; Region: PRK05428 681288002163 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 681288002164 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 681288002165 Hpr binding site; other site 681288002166 active site 681288002167 homohexamer subunit interaction site [polypeptide binding]; other site 681288002168 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 681288002169 putative acyl transferase; Provisional; Region: PRK10191 681288002170 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 681288002171 trimer interface [polypeptide binding]; other site 681288002172 active site 681288002173 substrate binding site [chemical binding]; other site 681288002174 CoA binding site [chemical binding]; other site 681288002175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 681288002176 binding surface 681288002177 TPR motif; other site 681288002178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288002179 TPR motif; other site 681288002180 binding surface 681288002181 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 681288002182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 681288002183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288002184 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 681288002185 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 681288002186 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 681288002187 phosphate binding site [ion binding]; other site 681288002188 dimer interface [polypeptide binding]; other site 681288002189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 681288002190 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 681288002191 Clp protease; Region: CLP_protease; pfam00574 681288002192 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 681288002193 oligomer interface [polypeptide binding]; other site 681288002194 active site residues [active] 681288002195 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 681288002196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002197 NAD(P) binding site [chemical binding]; other site 681288002198 active site 681288002199 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 681288002200 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 681288002201 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 681288002202 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 681288002203 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 681288002204 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 681288002205 Phosphoglycerate kinase; Region: PGK; pfam00162 681288002206 substrate binding site [chemical binding]; other site 681288002207 hinge regions; other site 681288002208 ADP binding site [chemical binding]; other site 681288002209 catalytic site [active] 681288002210 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 681288002211 triosephosphate isomerase; Provisional; Region: PRK14565 681288002212 substrate binding site [chemical binding]; other site 681288002213 dimer interface [polypeptide binding]; other site 681288002214 catalytic triad [active] 681288002215 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 681288002216 phosphoglyceromutase; Provisional; Region: PRK05434 681288002217 enolase; Provisional; Region: eno; PRK00077 681288002218 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 681288002219 dimer interface [polypeptide binding]; other site 681288002220 metal binding site [ion binding]; metal-binding site 681288002221 substrate binding pocket [chemical binding]; other site 681288002222 Preprotein translocase SecG subunit; Region: SecG; cl09123 681288002223 Esterase/lipase [General function prediction only]; Region: COG1647 681288002224 ribonuclease R; Region: RNase_R; TIGR02063 681288002225 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 681288002226 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 681288002227 RNB domain; Region: RNB; pfam00773 681288002228 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 681288002229 RNA binding site [nucleotide binding]; other site 681288002230 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 681288002231 SmpB-tmRNA interface; other site 681288002232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288002233 Coenzyme A binding pocket [chemical binding]; other site 681288002234 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 681288002235 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288002236 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 681288002237 Staphylococcal nuclease homologues; Region: SNc; smart00318 681288002238 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 681288002239 Catalytic site; other site 681288002240 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 681288002241 DNA-binding site [nucleotide binding]; DNA binding site 681288002242 RNA-binding motif; other site 681288002243 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 681288002244 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 681288002245 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 681288002246 catalytic core [active] 681288002247 Lysine efflux permease [General function prediction only]; Region: COG1279 681288002248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 681288002249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 681288002250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 681288002251 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 681288002252 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 681288002253 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 681288002254 active site 681288002255 catalytic residue [active] 681288002256 dimer interface [polypeptide binding]; other site 681288002257 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 681288002258 putative FMN binding site [chemical binding]; other site 681288002259 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 681288002260 catalytic residues [active] 681288002261 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 681288002262 ArsC family; Region: ArsC; pfam03960 681288002263 putative ArsC-like catalytic residues; other site 681288002264 putative TRX-like catalytic residues [active] 681288002265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 681288002266 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 681288002267 putative active site [active] 681288002268 putative metal binding site [ion binding]; other site 681288002269 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 681288002270 catalytic residues [active] 681288002271 SAAV_0983 681288002272 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 681288002273 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 681288002274 Walker A/P-loop; other site 681288002275 ATP binding site [chemical binding]; other site 681288002276 Q-loop/lid; other site 681288002277 ABC transporter signature motif; other site 681288002278 Walker B; other site 681288002279 D-loop; other site 681288002280 H-loop/switch region; other site 681288002281 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 681288002282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002283 dimer interface [polypeptide binding]; other site 681288002284 conserved gate region; other site 681288002285 ABC-ATPase subunit interface; other site 681288002286 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 681288002287 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 681288002288 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 681288002289 Int/Topo IB signature motif; other site 681288002290 SAP domain; Region: SAP; pfam02037 681288002291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288002292 non-specific DNA binding site [nucleotide binding]; other site 681288002293 salt bridge; other site 681288002294 sequence-specific DNA binding site [nucleotide binding]; other site 681288002295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288002296 non-specific DNA binding site [nucleotide binding]; other site 681288002297 salt bridge; other site 681288002298 sequence-specific DNA binding site [nucleotide binding]; other site 681288002299 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 681288002300 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 681288002301 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 681288002302 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 681288002303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 681288002304 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 681288002305 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 681288002306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 681288002307 Predicted membrane protein [Function unknown]; Region: COG2035 681288002308 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 681288002309 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 681288002310 Walker A/P-loop; other site 681288002311 ATP binding site [chemical binding]; other site 681288002312 Q-loop/lid; other site 681288002313 ABC transporter signature motif; other site 681288002314 Walker B; other site 681288002315 D-loop; other site 681288002316 H-loop/switch region; other site 681288002317 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 681288002318 FeS assembly protein SufD; Region: sufD; TIGR01981 681288002319 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 681288002320 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 681288002321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288002322 catalytic residue [active] 681288002323 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 681288002324 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 681288002325 trimerization site [polypeptide binding]; other site 681288002326 active site 681288002327 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 681288002328 FeS assembly protein SufB; Region: sufB; TIGR01980 681288002329 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 681288002330 active site 681288002331 DNA binding site [nucleotide binding] 681288002332 Int/Topo IB signature motif; other site 681288002333 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 681288002334 DpnII restriction endonuclease; Region: DpnII; pfam04556 681288002335 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 681288002336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288002337 non-specific DNA binding site [nucleotide binding]; other site 681288002338 salt bridge; other site 681288002339 sequence-specific DNA binding site [nucleotide binding]; other site 681288002340 Predicted transcriptional regulator [Transcription]; Region: COG2932 681288002341 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 681288002342 Catalytic site [active] 681288002343 Protein of unknown function (DUF739); Region: DUF739; pfam05339 681288002344 Phage anti-repressor protein [Transcription]; Region: COG3561 681288002345 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 681288002346 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 681288002347 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 681288002348 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 681288002349 ERF superfamily; Region: ERF; pfam04404 681288002350 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 681288002351 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 681288002352 dimer interface [polypeptide binding]; other site 681288002353 ssDNA binding site [nucleotide binding]; other site 681288002354 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288002355 Helix-turn-helix domain; Region: HTH_36; pfam13730 681288002356 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 681288002357 hypothetical protein; Validated; Region: PRK08116 681288002358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288002359 Walker A motif; other site 681288002360 ATP binding site [chemical binding]; other site 681288002361 Endodeoxyribonuclease RusA; Region: RusA; cl01885 681288002362 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 681288002363 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 681288002364 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 681288002365 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 681288002366 trimer interface [polypeptide binding]; other site 681288002367 active site 681288002368 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 681288002369 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 681288002370 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 681288002371 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 681288002372 putative metal binding site [ion binding]; other site 681288002373 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 681288002374 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 681288002375 active site 681288002376 Phage terminase, small subunit; Region: Terminase_4; pfam05119 681288002377 Phage Terminase; Region: Terminase_1; pfam03354 681288002378 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 681288002379 Phage-related protein [Function unknown]; Region: COG4695; cl01923 681288002380 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 681288002381 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 681288002382 Phage capsid family; Region: Phage_capsid; pfam05065 681288002383 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 681288002384 oligomerization interface [polypeptide binding]; other site 681288002385 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 681288002386 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 681288002387 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 681288002388 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 681288002389 Phage-related protein [Function unknown]; Region: COG5412 681288002390 Peptidase family M23; Region: Peptidase_M23; pfam01551 681288002391 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 681288002392 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 681288002393 N-acetyl-D-glucosamine binding site [chemical binding]; other site 681288002394 catalytic residue [active] 681288002395 Phage tail protein; Region: Sipho_tail; cl17486 681288002396 Phage tail protein; Region: Sipho_tail; cl17486 681288002397 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 681288002398 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 681288002399 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 681288002400 Ligand-gated ion channel; Region: Lig_chan; pfam00060 681288002401 holin, SPP1 family; Region: holin_SPP1; TIGR01592 681288002402 CHAP domain; Region: CHAP; pfam05257 681288002403 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 681288002404 active site 681288002405 metal binding site [ion binding]; metal-binding site 681288002406 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 681288002407 Domain of unknown function DUF21; Region: DUF21; pfam01595 681288002408 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 681288002409 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 681288002410 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 681288002411 FMN binding site [chemical binding]; other site 681288002412 substrate binding site [chemical binding]; other site 681288002413 putative catalytic residue [active] 681288002414 Uncharacterized conserved protein [Function unknown]; Region: COG1801 681288002415 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 681288002416 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 681288002417 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 681288002418 active site 681288002419 metal binding site [ion binding]; metal-binding site 681288002420 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 681288002421 lipoyl synthase; Provisional; Region: PRK05481 681288002422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288002423 FeS/SAM binding site; other site 681288002424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 681288002425 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 681288002426 Uncharacterized conserved protein [Function unknown]; Region: COG2445 681288002427 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 681288002428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288002429 active site 681288002430 motif I; other site 681288002431 motif II; other site 681288002432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288002433 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 681288002434 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 681288002435 dimerization interface [polypeptide binding]; other site 681288002436 ligand binding site [chemical binding]; other site 681288002437 NADP binding site [chemical binding]; other site 681288002438 catalytic site [active] 681288002439 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 681288002440 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 681288002441 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 681288002442 acyl-activating enzyme (AAE) consensus motif; other site 681288002443 AMP binding site [chemical binding]; other site 681288002444 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 681288002445 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 681288002446 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 681288002447 DltD N-terminal region; Region: DltD_N; pfam04915 681288002448 DltD central region; Region: DltD_M; pfam04918 681288002449 DltD C-terminal region; Region: DltD_C; pfam04914 681288002450 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 681288002451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 681288002452 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 681288002453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288002454 hypothetical protein; Provisional; Region: PRK13669 681288002455 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 681288002456 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 681288002457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288002458 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 681288002459 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 681288002460 interface (dimer of trimers) [polypeptide binding]; other site 681288002461 Substrate-binding/catalytic site; other site 681288002462 Zn-binding sites [ion binding]; other site 681288002463 Predicted permease [General function prediction only]; Region: COG2056 681288002464 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 681288002465 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 681288002466 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 681288002467 CoenzymeA binding site [chemical binding]; other site 681288002468 subunit interaction site [polypeptide binding]; other site 681288002469 PHB binding site; other site 681288002470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 681288002471 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 681288002472 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 681288002473 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 681288002474 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 681288002475 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 681288002476 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 681288002477 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 681288002478 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 681288002479 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 681288002480 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 681288002481 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 681288002482 Kinase associated protein B; Region: KapB; pfam08810 681288002483 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 681288002484 active site 681288002485 general stress protein 13; Validated; Region: PRK08059 681288002486 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 681288002487 RNA binding site [nucleotide binding]; other site 681288002488 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 681288002489 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 681288002490 putative active site [active] 681288002491 putative FMN binding site [chemical binding]; other site 681288002492 putative substrate binding site [chemical binding]; other site 681288002493 putative catalytic residue [active] 681288002494 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 681288002495 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288002496 inhibitor-cofactor binding pocket; inhibition site 681288002497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288002498 catalytic residue [active] 681288002499 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 681288002500 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 681288002501 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 681288002502 NAD(P) binding site [chemical binding]; other site 681288002503 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 681288002504 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 681288002505 active site 681288002506 catalytic site [active] 681288002507 metal binding site [ion binding]; metal-binding site 681288002508 argininosuccinate lyase; Provisional; Region: PRK00855 681288002509 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 681288002510 active sites [active] 681288002511 tetramer interface [polypeptide binding]; other site 681288002512 argininosuccinate synthase; Provisional; Region: PRK13820 681288002513 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 681288002514 ANP binding site [chemical binding]; other site 681288002515 Substrate Binding Site II [chemical binding]; other site 681288002516 Substrate Binding Site I [chemical binding]; other site 681288002517 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 681288002518 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 681288002519 active site 681288002520 dimer interface [polypeptide binding]; other site 681288002521 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 681288002522 dimer interface [polypeptide binding]; other site 681288002523 active site 681288002524 Uncharacterized conserved protein [Function unknown]; Region: COG0398 681288002525 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 681288002526 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 681288002527 Catalytic site [active] 681288002528 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 681288002529 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 681288002530 Catalytic site [active] 681288002531 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 681288002532 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 681288002533 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 681288002534 Part of AAA domain; Region: AAA_19; pfam13245 681288002535 Family description; Region: UvrD_C_2; pfam13538 681288002536 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 681288002537 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 681288002538 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 681288002539 hypothetical protein; Provisional; Region: PRK13673 681288002540 coenzyme A disulfide reductase; Provisional; Region: PRK13512 681288002541 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 681288002542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288002543 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 681288002544 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 681288002545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288002546 active site 681288002547 motif I; other site 681288002548 motif II; other site 681288002549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288002550 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 681288002551 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 681288002552 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 681288002553 catalytic triad [active] 681288002554 catalytic triad [active] 681288002555 oxyanion hole [active] 681288002556 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 681288002557 Clp amino terminal domain; Region: Clp_N; pfam02861 681288002558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288002559 Walker A motif; other site 681288002560 ATP binding site [chemical binding]; other site 681288002561 Walker B motif; other site 681288002562 arginine finger; other site 681288002563 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 681288002564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288002565 Walker A motif; other site 681288002566 ATP binding site [chemical binding]; other site 681288002567 Walker B motif; other site 681288002568 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 681288002569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 681288002570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 681288002571 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 681288002572 dimerization interface [polypeptide binding]; other site 681288002573 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 681288002574 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 681288002575 substrate binding site [chemical binding]; other site 681288002576 MAP domain; Region: MAP; pfam03642 681288002577 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 681288002578 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 681288002579 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 681288002580 dimer interface [polypeptide binding]; other site 681288002581 active site 681288002582 CoA binding pocket [chemical binding]; other site 681288002583 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 681288002584 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 681288002585 dimer interface [polypeptide binding]; other site 681288002586 active site 681288002587 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 681288002588 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 681288002589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002590 dimer interface [polypeptide binding]; other site 681288002591 conserved gate region; other site 681288002592 putative PBP binding loops; other site 681288002593 ABC-ATPase subunit interface; other site 681288002594 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 681288002595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002596 dimer interface [polypeptide binding]; other site 681288002597 conserved gate region; other site 681288002598 putative PBP binding loops; other site 681288002599 ABC-ATPase subunit interface; other site 681288002600 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 681288002601 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 681288002602 Walker A/P-loop; other site 681288002603 ATP binding site [chemical binding]; other site 681288002604 Q-loop/lid; other site 681288002605 ABC transporter signature motif; other site 681288002606 Walker B; other site 681288002607 D-loop; other site 681288002608 H-loop/switch region; other site 681288002609 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 681288002610 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 681288002611 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 681288002612 Walker A/P-loop; other site 681288002613 ATP binding site [chemical binding]; other site 681288002614 Q-loop/lid; other site 681288002615 ABC transporter signature motif; other site 681288002616 Walker B; other site 681288002617 D-loop; other site 681288002618 H-loop/switch region; other site 681288002619 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 681288002620 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 681288002621 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 681288002622 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 681288002623 peptide binding site [polypeptide binding]; other site 681288002624 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 681288002625 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 681288002626 peptide binding site [polypeptide binding]; other site 681288002627 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 681288002628 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 681288002629 Walker A/P-loop; other site 681288002630 ATP binding site [chemical binding]; other site 681288002631 Q-loop/lid; other site 681288002632 ABC transporter signature motif; other site 681288002633 Walker B; other site 681288002634 D-loop; other site 681288002635 H-loop/switch region; other site 681288002636 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 681288002637 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 681288002638 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 681288002639 Walker A/P-loop; other site 681288002640 ATP binding site [chemical binding]; other site 681288002641 Q-loop/lid; other site 681288002642 ABC transporter signature motif; other site 681288002643 Walker B; other site 681288002644 D-loop; other site 681288002645 H-loop/switch region; other site 681288002646 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 681288002647 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 681288002648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002649 dimer interface [polypeptide binding]; other site 681288002650 conserved gate region; other site 681288002651 putative PBP binding loops; other site 681288002652 ABC-ATPase subunit interface; other site 681288002653 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 681288002654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002655 dimer interface [polypeptide binding]; other site 681288002656 conserved gate region; other site 681288002657 putative PBP binding loops; other site 681288002658 ABC-ATPase subunit interface; other site 681288002659 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 681288002660 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 681288002661 active site 681288002662 HIGH motif; other site 681288002663 dimer interface [polypeptide binding]; other site 681288002664 KMSKS motif; other site 681288002665 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 681288002666 ArsC family; Region: ArsC; pfam03960 681288002667 putative catalytic residues [active] 681288002668 thiol/disulfide switch; other site 681288002669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288002670 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288002671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288002672 adaptor protein; Provisional; Region: PRK02315 681288002673 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 681288002674 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 681288002675 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 681288002676 active site 681288002677 Zn binding site [ion binding]; other site 681288002678 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 681288002679 Thioredoxin; Region: Thioredoxin_5; pfam13743 681288002680 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 681288002681 apolar tunnel; other site 681288002682 heme binding site [chemical binding]; other site 681288002683 dimerization interface [polypeptide binding]; other site 681288002684 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 681288002685 putative active site [active] 681288002686 putative metal binding residues [ion binding]; other site 681288002687 signature motif; other site 681288002688 putative triphosphate binding site [ion binding]; other site 681288002689 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 681288002690 synthetase active site [active] 681288002691 NTP binding site [chemical binding]; other site 681288002692 metal binding site [ion binding]; metal-binding site 681288002693 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 681288002694 ATP-NAD kinase; Region: NAD_kinase; pfam01513 681288002695 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 681288002696 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 681288002697 active site 681288002698 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 681288002699 MgtE intracellular N domain; Region: MgtE_N; smart00924 681288002700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 681288002701 Divalent cation transporter; Region: MgtE; pfam01769 681288002702 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 681288002703 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 681288002704 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 681288002705 TrkA-N domain; Region: TrkA_N; pfam02254 681288002706 TrkA-C domain; Region: TrkA_C; pfam02080 681288002707 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 681288002708 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 681288002709 NAD binding site [chemical binding]; other site 681288002710 homotetramer interface [polypeptide binding]; other site 681288002711 homodimer interface [polypeptide binding]; other site 681288002712 substrate binding site [chemical binding]; other site 681288002713 active site 681288002714 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 681288002715 Domain of unknown function DUF20; Region: UPF0118; pfam01594 681288002716 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 681288002717 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 681288002718 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 681288002719 Putative esterase; Region: Esterase; pfam00756 681288002720 hypothetical protein; Provisional; Region: PRK13679 681288002721 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 681288002722 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288002723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288002724 putative substrate translocation pore; other site 681288002725 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 681288002726 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 681288002727 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 681288002728 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 681288002729 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 681288002730 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288002731 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 681288002732 YueH-like protein; Region: YueH; pfam14166 681288002733 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 681288002734 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 681288002735 G1 box; other site 681288002736 putative GEF interaction site [polypeptide binding]; other site 681288002737 GTP/Mg2+ binding site [chemical binding]; other site 681288002738 Switch I region; other site 681288002739 G2 box; other site 681288002740 G3 box; other site 681288002741 Switch II region; other site 681288002742 G4 box; other site 681288002743 G5 box; other site 681288002744 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 681288002745 SAAV_0983 681288002746 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 681288002747 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 681288002748 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 681288002749 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 681288002750 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 681288002751 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 681288002752 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 681288002753 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 681288002754 active site 681288002755 metal binding site [ion binding]; metal-binding site 681288002756 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 681288002757 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 681288002758 IDEAL domain; Region: IDEAL; pfam08858 681288002759 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 681288002760 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 681288002761 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 681288002762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 681288002763 CAAX protease self-immunity; Region: Abi; pfam02517 681288002764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 681288002765 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 681288002766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 681288002767 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 681288002768 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 681288002769 Walker A/P-loop; other site 681288002770 ATP binding site [chemical binding]; other site 681288002771 Q-loop/lid; other site 681288002772 ABC transporter signature motif; other site 681288002773 Walker B; other site 681288002774 D-loop; other site 681288002775 H-loop/switch region; other site 681288002776 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 681288002777 Predicted membrane protein [Function unknown]; Region: COG2259 681288002778 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 681288002779 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 681288002780 siderophore binding site; other site 681288002781 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 681288002782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288002783 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 681288002784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 681288002785 Coenzyme A binding pocket [chemical binding]; other site 681288002786 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 681288002787 UbiA prenyltransferase family; Region: UbiA; pfam01040 681288002788 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 681288002789 isochorismate synthases; Region: isochor_syn; TIGR00543 681288002790 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 681288002791 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 681288002792 dimer interface [polypeptide binding]; other site 681288002793 tetramer interface [polypeptide binding]; other site 681288002794 PYR/PP interface [polypeptide binding]; other site 681288002795 TPP binding site [chemical binding]; other site 681288002796 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 681288002797 TPP-binding site; other site 681288002798 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 681288002799 PGAP1-like protein; Region: PGAP1; pfam07819 681288002800 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 681288002801 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 681288002802 substrate binding site [chemical binding]; other site 681288002803 oxyanion hole (OAH) forming residues; other site 681288002804 trimer interface [polypeptide binding]; other site 681288002805 Staphostatin B; Region: Staphostatin_B; pfam09023 681288002806 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 681288002807 aminotransferase A; Validated; Region: PRK07683 681288002808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288002809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288002810 homodimer interface [polypeptide binding]; other site 681288002811 catalytic residue [active] 681288002812 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 681288002813 Acyltransferase family; Region: Acyl_transf_3; pfam01757 681288002814 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288002815 MarR family; Region: MarR; pfam01047 681288002816 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 681288002817 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 681288002818 amidase catalytic site [active] 681288002819 Zn binding residues [ion binding]; other site 681288002820 substrate binding site [chemical binding]; other site 681288002821 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 681288002822 Lysozyme subfamily 2; Region: LYZ2; smart00047 681288002823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288002824 Coenzyme A binding pocket [chemical binding]; other site 681288002825 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 681288002826 Transcriptional regulator [Transcription]; Region: LytR; COG1316 681288002827 Beta-lactamase; Region: Beta-lactamase; pfam00144 681288002828 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 681288002829 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 681288002830 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 681288002831 Subunit I/III interface [polypeptide binding]; other site 681288002832 Subunit III/IV interface [polypeptide binding]; other site 681288002833 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 681288002834 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 681288002835 D-pathway; other site 681288002836 Putative ubiquinol binding site [chemical binding]; other site 681288002837 Low-spin heme (heme b) binding site [chemical binding]; other site 681288002838 Putative water exit pathway; other site 681288002839 Binuclear center (heme o3/CuB) [ion binding]; other site 681288002840 K-pathway; other site 681288002841 Putative proton exit pathway; other site 681288002842 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 681288002843 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 681288002844 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 681288002845 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 681288002846 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 681288002847 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 681288002848 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 681288002849 homodimer interface [polypeptide binding]; other site 681288002850 NADP binding site [chemical binding]; other site 681288002851 substrate binding site [chemical binding]; other site 681288002852 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 681288002853 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 681288002854 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 681288002855 NAD binding site [chemical binding]; other site 681288002856 ATP-grasp domain; Region: ATP-grasp; pfam02222 681288002857 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 681288002858 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 681288002859 ATP binding site [chemical binding]; other site 681288002860 active site 681288002861 substrate binding site [chemical binding]; other site 681288002862 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 681288002863 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 681288002864 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 681288002865 putative active site [active] 681288002866 catalytic triad [active] 681288002867 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 681288002868 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 681288002869 dimerization interface [polypeptide binding]; other site 681288002870 ATP binding site [chemical binding]; other site 681288002871 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 681288002872 dimerization interface [polypeptide binding]; other site 681288002873 ATP binding site [chemical binding]; other site 681288002874 amidophosphoribosyltransferase; Provisional; Region: PRK07272 681288002875 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 681288002876 active site 681288002877 tetramer interface [polypeptide binding]; other site 681288002878 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288002879 active site 681288002880 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 681288002881 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 681288002882 dimerization interface [polypeptide binding]; other site 681288002883 putative ATP binding site [chemical binding]; other site 681288002884 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 681288002885 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 681288002886 active site 681288002887 substrate binding site [chemical binding]; other site 681288002888 cosubstrate binding site; other site 681288002889 catalytic site [active] 681288002890 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 681288002891 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 681288002892 purine monophosphate binding site [chemical binding]; other site 681288002893 dimer interface [polypeptide binding]; other site 681288002894 putative catalytic residues [active] 681288002895 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 681288002896 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 681288002897 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 681288002898 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 681288002899 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 681288002900 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 681288002901 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 681288002902 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 681288002903 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 681288002904 Walker A/P-loop; other site 681288002905 ATP binding site [chemical binding]; other site 681288002906 Q-loop/lid; other site 681288002907 ABC transporter signature motif; other site 681288002908 Walker B; other site 681288002909 D-loop; other site 681288002910 H-loop/switch region; other site 681288002911 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 681288002912 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 681288002913 Walker A/P-loop; other site 681288002914 ATP binding site [chemical binding]; other site 681288002915 Q-loop/lid; other site 681288002916 ABC transporter signature motif; other site 681288002917 Walker B; other site 681288002918 D-loop; other site 681288002919 H-loop/switch region; other site 681288002920 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 681288002921 SAAV_1043 681288002922 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 681288002923 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 681288002924 putative RNA binding site [nucleotide binding]; other site 681288002925 Methyltransferase domain; Region: Methyltransf_26; pfam13659 681288002926 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 681288002927 dimerization domain swap beta strand [polypeptide binding]; other site 681288002928 regulatory protein interface [polypeptide binding]; other site 681288002929 active site 681288002930 regulatory phosphorylation site [posttranslational modification]; other site 681288002931 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 681288002932 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 681288002933 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 681288002934 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 681288002935 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 681288002936 catalytic residues [active] 681288002937 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 681288002938 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 681288002939 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 681288002940 TrkA-N domain; Region: TrkA_N; pfam02254 681288002941 TrkA-C domain; Region: TrkA_C; pfam02080 681288002942 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 681288002943 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 681288002944 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 681288002945 hypothetical protein; Provisional; Region: PRK13667 681288002946 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 681288002947 active site 681288002948 catalytic residues [active] 681288002949 metal binding site [ion binding]; metal-binding site 681288002950 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 681288002951 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 681288002952 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 681288002953 TPP-binding site [chemical binding]; other site 681288002954 tetramer interface [polypeptide binding]; other site 681288002955 heterodimer interface [polypeptide binding]; other site 681288002956 phosphorylation loop region [posttranslational modification] 681288002957 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 681288002958 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 681288002959 alpha subunit interface [polypeptide binding]; other site 681288002960 TPP binding site [chemical binding]; other site 681288002961 heterodimer interface [polypeptide binding]; other site 681288002962 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 681288002963 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 681288002964 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 681288002965 E3 interaction surface; other site 681288002966 lipoyl attachment site [posttranslational modification]; other site 681288002967 e3 binding domain; Region: E3_binding; pfam02817 681288002968 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 681288002969 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 681288002970 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 681288002971 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288002972 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 681288002973 hypothetical protein; Provisional; Region: PRK04387 681288002974 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 681288002975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288002976 non-specific DNA binding site [nucleotide binding]; other site 681288002977 salt bridge; other site 681288002978 sequence-specific DNA binding site [nucleotide binding]; other site 681288002979 Cupin domain; Region: Cupin_2; pfam07883 681288002980 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 681288002981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288002982 Walker A/P-loop; other site 681288002983 ATP binding site [chemical binding]; other site 681288002984 Q-loop/lid; other site 681288002985 ABC transporter signature motif; other site 681288002986 Walker B; other site 681288002987 D-loop; other site 681288002988 H-loop/switch region; other site 681288002989 TOBE domain; Region: TOBE_2; pfam08402 681288002990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002991 putative PBP binding loops; other site 681288002992 dimer interface [polypeptide binding]; other site 681288002993 ABC-ATPase subunit interface; other site 681288002994 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 681288002995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002996 dimer interface [polypeptide binding]; other site 681288002997 conserved gate region; other site 681288002998 putative PBP binding loops; other site 681288002999 ABC-ATPase subunit interface; other site 681288003000 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 681288003001 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 681288003002 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 681288003003 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 681288003004 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 681288003005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288003006 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288003007 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 681288003008 manganese transport protein MntH; Reviewed; Region: PRK00701 681288003009 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 681288003010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 681288003011 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 681288003012 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 681288003013 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 681288003014 active site 681288003015 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 681288003016 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 681288003017 G1 box; other site 681288003018 putative GEF interaction site [polypeptide binding]; other site 681288003019 GTP/Mg2+ binding site [chemical binding]; other site 681288003020 Switch I region; other site 681288003021 G2 box; other site 681288003022 G3 box; other site 681288003023 Switch II region; other site 681288003024 G4 box; other site 681288003025 G5 box; other site 681288003026 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 681288003027 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 681288003028 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 681288003029 hypothetical protein; Provisional; Region: PRK13666 681288003030 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 681288003031 pyruvate carboxylase; Reviewed; Region: PRK12999 681288003032 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 681288003033 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 681288003034 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 681288003035 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 681288003036 active site 681288003037 catalytic residues [active] 681288003038 metal binding site [ion binding]; metal-binding site 681288003039 homodimer binding site [polypeptide binding]; other site 681288003040 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 681288003041 carboxyltransferase (CT) interaction site; other site 681288003042 biotinylation site [posttranslational modification]; other site 681288003043 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 681288003044 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 681288003045 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 681288003046 UbiA prenyltransferase family; Region: UbiA; pfam01040 681288003047 Predicted membrane protein [Function unknown]; Region: COG2322 681288003048 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 681288003049 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 681288003050 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 681288003051 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 681288003052 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 681288003053 putative active site [active] 681288003054 catalytic site [active] 681288003055 putative metal binding site [ion binding]; other site 681288003056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 681288003057 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 681288003058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288003059 S-adenosylmethionine binding site [chemical binding]; other site 681288003060 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 681288003061 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 681288003062 active site 681288003063 (T/H)XGH motif; other site 681288003064 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 681288003065 hypothetical protein; Provisional; Region: PRK13670 681288003066 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 681288003067 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 681288003068 heme uptake protein IsdB; Region: IsdB; TIGR03657 681288003069 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 681288003070 NEAr Transporter domain; Region: NEAT; smart00725 681288003071 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 681288003072 heme-binding site [chemical binding]; other site 681288003073 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 681288003074 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 681288003075 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 681288003076 heme-binding site [chemical binding]; other site 681288003077 heme uptake protein IsdC; Region: IsdC; TIGR03656 681288003078 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 681288003079 heme-binding site [chemical binding]; other site 681288003080 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 681288003081 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 681288003082 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 681288003083 intersubunit interface [polypeptide binding]; other site 681288003084 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 681288003085 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288003086 ABC-ATPase subunit interface; other site 681288003087 dimer interface [polypeptide binding]; other site 681288003088 putative PBP binding regions; other site 681288003089 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 681288003090 active site 681288003091 catalytic site [active] 681288003092 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 681288003093 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 681288003094 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 681288003095 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 681288003096 SAAV_1104 681288003097 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 681288003098 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 681288003099 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 681288003100 dimer interface [polypeptide binding]; other site 681288003101 motif 1; other site 681288003102 active site 681288003103 motif 2; other site 681288003104 motif 3; other site 681288003105 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 681288003106 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 681288003107 putative tRNA-binding site [nucleotide binding]; other site 681288003108 B3/4 domain; Region: B3_4; pfam03483 681288003109 tRNA synthetase B5 domain; Region: B5; smart00874 681288003110 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 681288003111 dimer interface [polypeptide binding]; other site 681288003112 motif 1; other site 681288003113 motif 3; other site 681288003114 motif 2; other site 681288003115 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 681288003116 ribonuclease HIII; Provisional; Region: PRK00996 681288003117 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 681288003118 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 681288003119 RNA/DNA hybrid binding site [nucleotide binding]; other site 681288003120 active site 681288003121 Cell division protein ZapA; Region: ZapA; cl01146 681288003122 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 681288003123 Colicin V production protein; Region: Colicin_V; pfam02674 681288003124 hypothetical protein; Provisional; Region: PRK08609 681288003125 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 681288003126 active site 681288003127 primer binding site [nucleotide binding]; other site 681288003128 NTP binding site [chemical binding]; other site 681288003129 metal binding triad [ion binding]; metal-binding site 681288003130 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 681288003131 active site 681288003132 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 681288003133 MutS domain III; Region: MutS_III; pfam05192 681288003134 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 681288003135 Walker A/P-loop; other site 681288003136 ATP binding site [chemical binding]; other site 681288003137 Q-loop/lid; other site 681288003138 ABC transporter signature motif; other site 681288003139 Walker B; other site 681288003140 D-loop; other site 681288003141 H-loop/switch region; other site 681288003142 Smr domain; Region: Smr; pfam01713 681288003143 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 681288003144 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 681288003145 catalytic residues [active] 681288003146 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 681288003147 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 681288003148 GIY-YIG motif/motif A; other site 681288003149 active site 681288003150 catalytic site [active] 681288003151 putative DNA binding site [nucleotide binding]; other site 681288003152 metal binding site [ion binding]; metal-binding site 681288003153 UvrB/uvrC motif; Region: UVR; pfam02151 681288003154 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 681288003155 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 681288003156 putative Iron-sulfur protein interface [polypeptide binding]; other site 681288003157 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 681288003158 proximal heme binding site [chemical binding]; other site 681288003159 distal heme binding site [chemical binding]; other site 681288003160 putative dimer interface [polypeptide binding]; other site 681288003161 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 681288003162 L-aspartate oxidase; Provisional; Region: PRK06175 681288003163 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 681288003164 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 681288003165 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 681288003166 glutamate racemase; Provisional; Region: PRK00865 681288003167 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 681288003168 active site 681288003169 dimerization interface [polypeptide binding]; other site 681288003170 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 681288003171 active site 681288003172 metal binding site [ion binding]; metal-binding site 681288003173 homotetramer interface [polypeptide binding]; other site 681288003174 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 681288003175 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 681288003176 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 681288003177 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 681288003178 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288003179 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288003180 beta-channel forming cytolysin; Region: hlyII; TIGR01002 681288003181 superantigen-like protein; Reviewed; Region: PRK13350 681288003182 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288003183 superantigen-like protein; Reviewed; Region: PRK13349 681288003184 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288003185 superantigen-like protein; Reviewed; Region: PRK13043 681288003186 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288003187 ornithine carbamoyltransferase; Provisional; Region: PRK04284 681288003188 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 681288003189 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 681288003190 carbamate kinase; Reviewed; Region: PRK12686 681288003191 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 681288003192 putative substrate binding site [chemical binding]; other site 681288003193 nucleotide binding site [chemical binding]; other site 681288003194 nucleotide binding site [chemical binding]; other site 681288003195 homodimer interface [polypeptide binding]; other site 681288003196 Predicted membrane protein [Function unknown]; Region: COG1288 681288003197 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 681288003198 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 681288003199 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 681288003200 gating phenylalanine in ion channel; other site 681288003201 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 681288003202 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 681288003203 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 681288003204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288003205 motif II; other site 681288003206 hypothetical protein; Provisional; Region: PRK13688 681288003207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 681288003208 Coenzyme A binding pocket [chemical binding]; other site 681288003209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 681288003210 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 681288003211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 681288003212 MraZ protein; Region: MraZ; pfam02381 681288003213 MraZ protein; Region: MraZ; pfam02381 681288003214 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 681288003215 MraW methylase family; Region: Methyltransf_5; pfam01795 681288003216 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 681288003217 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 681288003218 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 681288003219 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 681288003220 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 681288003221 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 681288003222 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 681288003223 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 681288003224 Mg++ binding site [ion binding]; other site 681288003225 putative catalytic motif [active] 681288003226 putative substrate binding site [chemical binding]; other site 681288003227 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 681288003228 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 681288003229 NAD binding site [chemical binding]; other site 681288003230 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288003231 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 681288003232 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 681288003233 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 681288003234 Cell division protein FtsQ; Region: FtsQ; pfam03799 681288003235 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 681288003236 Cell division protein FtsA; Region: FtsA; smart00842 681288003237 Cell division protein FtsA; Region: FtsA; pfam14450 681288003238 cell division protein FtsZ; Validated; Region: PRK09330 681288003239 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 681288003240 nucleotide binding site [chemical binding]; other site 681288003241 SulA interaction site; other site 681288003242 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 681288003243 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 681288003244 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 681288003245 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288003246 catalytic residue [active] 681288003247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 681288003248 YGGT family; Region: YGGT; pfam02325 681288003249 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 681288003250 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288003251 RNA binding surface [nucleotide binding]; other site 681288003252 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 681288003253 DivIVA domain; Region: DivI1A_domain; TIGR03544 681288003254 SAAV_1164 681288003255 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 681288003256 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 681288003257 HIGH motif; other site 681288003258 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 681288003259 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 681288003260 active site 681288003261 KMSKS motif; other site 681288003262 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 681288003263 tRNA binding surface [nucleotide binding]; other site 681288003264 anticodon binding site; other site 681288003265 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 681288003266 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 681288003267 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 681288003268 active site 681288003269 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 681288003270 lipoprotein signal peptidase; Provisional; Region: PRK14787 681288003271 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 681288003272 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288003273 RNA binding surface [nucleotide binding]; other site 681288003274 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 681288003275 active site 681288003276 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 681288003277 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 681288003278 uracil transporter; Provisional; Region: PRK10720 681288003279 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 681288003280 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 681288003281 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 681288003282 dihydroorotase; Validated; Region: pyrC; PRK09357 681288003283 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 681288003284 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 681288003285 active site 681288003286 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 681288003287 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 681288003288 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 681288003289 catalytic site [active] 681288003290 subunit interface [polypeptide binding]; other site 681288003291 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 681288003292 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 681288003293 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 681288003294 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 681288003295 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 681288003296 ATP-grasp domain; Region: ATP-grasp_4; cl17255 681288003297 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 681288003298 IMP binding site; other site 681288003299 dimer interface [polypeptide binding]; other site 681288003300 interdomain contacts; other site 681288003301 partial ornithine binding site; other site 681288003302 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 681288003303 active site 681288003304 dimer interface [polypeptide binding]; other site 681288003305 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288003306 active site 681288003307 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 681288003308 dimer interface [polypeptide binding]; other site 681288003309 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 681288003310 Domain of unknown function (DUF814); Region: DUF814; pfam05670 681288003311 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 681288003312 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 681288003313 catalytic site [active] 681288003314 G-X2-G-X-G-K; other site 681288003315 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 681288003316 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 681288003317 Flavoprotein; Region: Flavoprotein; pfam02441 681288003318 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 681288003319 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 681288003320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288003321 ATP binding site [chemical binding]; other site 681288003322 putative Mg++ binding site [ion binding]; other site 681288003323 helicase superfamily c-terminal domain; Region: HELICc; smart00490 681288003324 nucleotide binding region [chemical binding]; other site 681288003325 ATP-binding site [chemical binding]; other site 681288003326 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 681288003327 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 681288003328 active site 681288003329 catalytic residues [active] 681288003330 metal binding site [ion binding]; metal-binding site 681288003331 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 681288003332 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 681288003333 putative active site [active] 681288003334 substrate binding site [chemical binding]; other site 681288003335 putative cosubstrate binding site; other site 681288003336 catalytic site [active] 681288003337 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 681288003338 substrate binding site [chemical binding]; other site 681288003339 16S rRNA methyltransferase B; Provisional; Region: PRK14902 681288003340 NusB family; Region: NusB; pfam01029 681288003341 putative RNA binding site [nucleotide binding]; other site 681288003342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288003343 S-adenosylmethionine binding site [chemical binding]; other site 681288003344 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 681288003345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288003346 FeS/SAM binding site; other site 681288003347 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 681288003348 Protein phosphatase 2C; Region: PP2C; pfam00481 681288003349 active site 681288003350 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 681288003351 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 681288003352 active site 681288003353 ATP binding site [chemical binding]; other site 681288003354 substrate binding site [chemical binding]; other site 681288003355 activation loop (A-loop); other site 681288003356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 681288003357 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 681288003358 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 681288003359 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 681288003360 Predicted GTPases [General function prediction only]; Region: COG1162 681288003361 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 681288003362 RNA binding site [nucleotide binding]; other site 681288003363 homodimer interface [polypeptide binding]; other site 681288003364 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 681288003365 GTPase/Zn-binding domain interface [polypeptide binding]; other site 681288003366 GTP/Mg2+ binding site [chemical binding]; other site 681288003367 G4 box; other site 681288003368 G5 box; other site 681288003369 G1 box; other site 681288003370 Switch I region; other site 681288003371 G2 box; other site 681288003372 G3 box; other site 681288003373 Switch II region; other site 681288003374 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 681288003375 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 681288003376 substrate binding site [chemical binding]; other site 681288003377 hexamer interface [polypeptide binding]; other site 681288003378 metal binding site [ion binding]; metal-binding site 681288003379 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 681288003380 Thiamine pyrophosphokinase; Region: TPK; cd07995 681288003381 active site 681288003382 dimerization interface [polypeptide binding]; other site 681288003383 thiamine binding site [chemical binding]; other site 681288003384 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 681288003385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 681288003386 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 681288003387 DAK2 domain; Region: Dak2; pfam02734 681288003388 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 681288003389 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 681288003390 generic binding surface II; other site 681288003391 ssDNA binding site; other site 681288003392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288003393 ATP binding site [chemical binding]; other site 681288003394 putative Mg++ binding site [ion binding]; other site 681288003395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288003396 nucleotide binding region [chemical binding]; other site 681288003397 ATP-binding site [chemical binding]; other site 681288003398 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 681288003399 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 681288003400 active site 2 [active] 681288003401 active site 1 [active] 681288003402 putative phosphate acyltransferase; Provisional; Region: PRK05331 681288003403 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 681288003404 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 681288003405 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 681288003406 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 681288003407 NAD(P) binding site [chemical binding]; other site 681288003408 homotetramer interface [polypeptide binding]; other site 681288003409 homodimer interface [polypeptide binding]; other site 681288003410 active site 681288003411 acyl carrier protein; Provisional; Region: acpP; PRK00982 681288003412 ribonuclease III; Reviewed; Region: rnc; PRK00102 681288003413 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 681288003414 dimerization interface [polypeptide binding]; other site 681288003415 active site 681288003416 metal binding site [ion binding]; metal-binding site 681288003417 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 681288003418 dsRNA binding site [nucleotide binding]; other site 681288003419 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 681288003420 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 681288003421 Walker A/P-loop; other site 681288003422 ATP binding site [chemical binding]; other site 681288003423 Q-loop/lid; other site 681288003424 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 681288003425 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 681288003426 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 681288003427 ABC transporter signature motif; other site 681288003428 Walker B; other site 681288003429 D-loop; other site 681288003430 H-loop/switch region; other site 681288003431 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 681288003432 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 681288003433 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 681288003434 P loop; other site 681288003435 GTP binding site [chemical binding]; other site 681288003436 putative DNA-binding protein; Validated; Region: PRK00118 681288003437 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 681288003438 signal recognition particle protein; Provisional; Region: PRK10867 681288003439 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 681288003440 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 681288003441 P loop; other site 681288003442 GTP binding site [chemical binding]; other site 681288003443 Signal peptide binding domain; Region: SRP_SPB; pfam02978 681288003444 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 681288003445 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 681288003446 RimM N-terminal domain; Region: RimM; pfam01782 681288003447 PRC-barrel domain; Region: PRC; pfam05239 681288003448 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 681288003449 SAAV_1214 681288003450 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 681288003451 Predicted membrane protein [Function unknown]; Region: COG4485 681288003452 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 681288003453 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 681288003454 GTP/Mg2+ binding site [chemical binding]; other site 681288003455 G4 box; other site 681288003456 G5 box; other site 681288003457 G1 box; other site 681288003458 Switch I region; other site 681288003459 G2 box; other site 681288003460 G3 box; other site 681288003461 Switch II region; other site 681288003462 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 681288003463 RNA/DNA hybrid binding site [nucleotide binding]; other site 681288003464 active site 681288003465 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 681288003466 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 681288003467 CoA-ligase; Region: Ligase_CoA; pfam00549 681288003468 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 681288003469 CoA binding domain; Region: CoA_binding; pfam02629 681288003470 CoA-ligase; Region: Ligase_CoA; pfam00549 681288003471 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 681288003472 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 681288003473 CHAP domain; Region: CHAP; pfam05257 681288003474 FemAB family; Region: FemAB; pfam02388 681288003475 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 681288003476 DNA protecting protein DprA; Region: dprA; TIGR00732 681288003477 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 681288003478 DNA topoisomerase I; Validated; Region: PRK05582 681288003479 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 681288003480 active site 681288003481 interdomain interaction site; other site 681288003482 putative metal-binding site [ion binding]; other site 681288003483 nucleotide binding site [chemical binding]; other site 681288003484 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 681288003485 domain I; other site 681288003486 DNA binding groove [nucleotide binding] 681288003487 phosphate binding site [ion binding]; other site 681288003488 domain II; other site 681288003489 domain III; other site 681288003490 nucleotide binding site [chemical binding]; other site 681288003491 catalytic site [active] 681288003492 domain IV; other site 681288003493 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 681288003494 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 681288003495 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 681288003496 Glucose inhibited division protein A; Region: GIDA; pfam01134 681288003497 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 681288003498 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 681288003499 active site 681288003500 DNA binding site [nucleotide binding] 681288003501 Int/Topo IB signature motif; other site 681288003502 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 681288003503 active site 681288003504 HslU subunit interaction site [polypeptide binding]; other site 681288003505 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 681288003506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288003507 Walker A motif; other site 681288003508 ATP binding site [chemical binding]; other site 681288003509 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 681288003510 Walker B motif; other site 681288003511 arginine finger; other site 681288003512 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 681288003513 transcriptional repressor CodY; Validated; Region: PRK04158 681288003514 CodY GAF-like domain; Region: CodY; pfam06018 681288003515 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 681288003516 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 681288003517 rRNA interaction site [nucleotide binding]; other site 681288003518 S8 interaction site; other site 681288003519 putative laminin-1 binding site; other site 681288003520 elongation factor Ts; Provisional; Region: tsf; PRK09377 681288003521 UBA/TS-N domain; Region: UBA; pfam00627 681288003522 Elongation factor TS; Region: EF_TS; pfam00889 681288003523 Elongation factor TS; Region: EF_TS; pfam00889 681288003524 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 681288003525 putative nucleotide binding site [chemical binding]; other site 681288003526 uridine monophosphate binding site [chemical binding]; other site 681288003527 homohexameric interface [polypeptide binding]; other site 681288003528 ribosome recycling factor; Reviewed; Region: frr; PRK00083 681288003529 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 681288003530 hinge region; other site 681288003531 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 681288003532 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 681288003533 catalytic residue [active] 681288003534 putative FPP diphosphate binding site; other site 681288003535 putative FPP binding hydrophobic cleft; other site 681288003536 dimer interface [polypeptide binding]; other site 681288003537 putative IPP diphosphate binding site; other site 681288003538 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 681288003539 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 681288003540 RIP metalloprotease RseP; Region: TIGR00054 681288003541 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 681288003542 active site 681288003543 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 681288003544 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 681288003545 protein binding site [polypeptide binding]; other site 681288003546 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 681288003547 putative substrate binding region [chemical binding]; other site 681288003548 prolyl-tRNA synthetase; Provisional; Region: PRK09194 681288003549 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 681288003550 dimer interface [polypeptide binding]; other site 681288003551 motif 1; other site 681288003552 active site 681288003553 motif 2; other site 681288003554 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 681288003555 putative deacylase active site [active] 681288003556 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 681288003557 active site 681288003558 motif 3; other site 681288003559 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 681288003560 anticodon binding site; other site 681288003561 DNA polymerase III PolC; Validated; Region: polC; PRK00448 681288003562 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 681288003563 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 681288003564 generic binding surface II; other site 681288003565 generic binding surface I; other site 681288003566 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 681288003567 active site 681288003568 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 681288003569 active site 681288003570 catalytic site [active] 681288003571 substrate binding site [chemical binding]; other site 681288003572 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 681288003573 ribosome maturation protein RimP; Reviewed; Region: PRK00092 681288003574 Sm and related proteins; Region: Sm_like; cl00259 681288003575 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 681288003576 putative oligomer interface [polypeptide binding]; other site 681288003577 putative RNA binding site [nucleotide binding]; other site 681288003578 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 681288003579 NusA N-terminal domain; Region: NusA_N; pfam08529 681288003580 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 681288003581 RNA binding site [nucleotide binding]; other site 681288003582 homodimer interface [polypeptide binding]; other site 681288003583 NusA-like KH domain; Region: KH_5; pfam13184 681288003584 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 681288003585 G-X-X-G motif; other site 681288003586 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 681288003587 putative RNA binding cleft [nucleotide binding]; other site 681288003588 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 681288003589 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 681288003590 translation initiation factor IF-2; Region: IF-2; TIGR00487 681288003591 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 681288003592 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 681288003593 G1 box; other site 681288003594 putative GEF interaction site [polypeptide binding]; other site 681288003595 GTP/Mg2+ binding site [chemical binding]; other site 681288003596 Switch I region; other site 681288003597 G2 box; other site 681288003598 G3 box; other site 681288003599 Switch II region; other site 681288003600 G4 box; other site 681288003601 G5 box; other site 681288003602 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 681288003603 Translation-initiation factor 2; Region: IF-2; pfam11987 681288003604 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 681288003605 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 681288003606 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 681288003607 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 681288003608 RNA binding site [nucleotide binding]; other site 681288003609 active site 681288003610 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 681288003611 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 681288003612 active site 681288003613 Riboflavin kinase; Region: Flavokinase; smart00904 681288003614 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 681288003615 16S/18S rRNA binding site [nucleotide binding]; other site 681288003616 S13e-L30e interaction site [polypeptide binding]; other site 681288003617 25S rRNA binding site [nucleotide binding]; other site 681288003618 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 681288003619 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 681288003620 RNase E interface [polypeptide binding]; other site 681288003621 trimer interface [polypeptide binding]; other site 681288003622 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 681288003623 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 681288003624 RNase E interface [polypeptide binding]; other site 681288003625 trimer interface [polypeptide binding]; other site 681288003626 active site 681288003627 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 681288003628 putative nucleic acid binding region [nucleotide binding]; other site 681288003629 G-X-X-G motif; other site 681288003630 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 681288003631 RNA binding site [nucleotide binding]; other site 681288003632 domain interface; other site 681288003633 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 681288003634 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 681288003635 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 681288003636 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 681288003637 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 681288003638 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 681288003639 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 681288003640 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 681288003641 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 681288003642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 681288003643 DNA-binding site [nucleotide binding]; DNA binding site 681288003644 UTRA domain; Region: UTRA; pfam07702 681288003645 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 681288003646 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 681288003647 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 681288003648 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 681288003649 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 681288003650 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 681288003651 classical (c) SDRs; Region: SDR_c; cd05233 681288003652 NAD(P) binding site [chemical binding]; other site 681288003653 active site 681288003654 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 681288003655 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 681288003656 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 681288003657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288003658 non-specific DNA binding site [nucleotide binding]; other site 681288003659 salt bridge; other site 681288003660 sequence-specific DNA binding site [nucleotide binding]; other site 681288003661 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 681288003662 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 681288003663 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 681288003664 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 681288003665 putative MPT binding site; other site 681288003666 recombinase A; Provisional; Region: recA; PRK09354 681288003667 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 681288003668 hexamer interface [polypeptide binding]; other site 681288003669 Walker A motif; other site 681288003670 ATP binding site [chemical binding]; other site 681288003671 Walker B motif; other site 681288003672 phosphodiesterase; Provisional; Region: PRK12704 681288003673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 681288003674 Zn2+ binding site [ion binding]; other site 681288003675 Mg2+ binding site [ion binding]; other site 681288003676 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 681288003677 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 681288003678 putative active site [active] 681288003679 metal binding site [ion binding]; metal-binding site 681288003680 homodimer binding site [polypeptide binding]; other site 681288003681 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 681288003682 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 681288003683 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 681288003684 dimer interface [polypeptide binding]; other site 681288003685 PYR/PP interface [polypeptide binding]; other site 681288003686 TPP binding site [chemical binding]; other site 681288003687 substrate binding site [chemical binding]; other site 681288003688 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 681288003689 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 681288003690 TPP-binding site [chemical binding]; other site 681288003691 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 681288003692 Uncharacterized conserved protein [Function unknown]; Region: COG0011 681288003693 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 681288003694 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 681288003695 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288003696 FeS/SAM binding site; other site 681288003697 TRAM domain; Region: TRAM; pfam01938 681288003698 Predicted membrane protein [Function unknown]; Region: COG4550 681288003699 Predicted membrane protein [Function unknown]; Region: COG4732 681288003700 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 681288003701 MutS domain I; Region: MutS_I; pfam01624 681288003702 MutS domain II; Region: MutS_II; pfam05188 681288003703 MutS domain III; Region: MutS_III; pfam05192 681288003704 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 681288003705 Walker A/P-loop; other site 681288003706 ATP binding site [chemical binding]; other site 681288003707 Q-loop/lid; other site 681288003708 ABC transporter signature motif; other site 681288003709 Walker B; other site 681288003710 D-loop; other site 681288003711 H-loop/switch region; other site 681288003712 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 681288003713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288003714 ATP binding site [chemical binding]; other site 681288003715 Mg2+ binding site [ion binding]; other site 681288003716 G-X-G motif; other site 681288003717 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 681288003718 ATP binding site [chemical binding]; other site 681288003719 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 681288003720 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 681288003721 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 681288003722 amphipathic channel; other site 681288003723 Asn-Pro-Ala signature motifs; other site 681288003724 glycerol kinase; Provisional; Region: glpK; PRK00047 681288003725 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 681288003726 N- and C-terminal domain interface [polypeptide binding]; other site 681288003727 active site 681288003728 MgATP binding site [chemical binding]; other site 681288003729 catalytic site [active] 681288003730 metal binding site [ion binding]; metal-binding site 681288003731 glycerol binding site [chemical binding]; other site 681288003732 homotetramer interface [polypeptide binding]; other site 681288003733 homodimer interface [polypeptide binding]; other site 681288003734 FBP binding site [chemical binding]; other site 681288003735 protein IIAGlc interface [polypeptide binding]; other site 681288003736 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 681288003737 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 681288003738 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 681288003739 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 681288003740 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 681288003741 bacterial Hfq-like; Region: Hfq; cd01716 681288003742 hexamer interface [polypeptide binding]; other site 681288003743 Sm1 motif; other site 681288003744 RNA binding site [nucleotide binding]; other site 681288003745 Sm2 motif; other site 681288003746 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 681288003747 catalytic residues [active] 681288003748 dimer interface [polypeptide binding]; other site 681288003749 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 681288003750 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 681288003751 HflX GTPase family; Region: HflX; cd01878 681288003752 G1 box; other site 681288003753 GTP/Mg2+ binding site [chemical binding]; other site 681288003754 Switch I region; other site 681288003755 G2 box; other site 681288003756 G3 box; other site 681288003757 Switch II region; other site 681288003758 G4 box; other site 681288003759 G5 box; other site 681288003760 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 681288003761 Aluminium resistance protein; Region: Alum_res; pfam06838 681288003762 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 681288003763 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 681288003764 DNA binding residues [nucleotide binding] 681288003765 putative dimer interface [polypeptide binding]; other site 681288003766 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 681288003767 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 681288003768 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 681288003769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 681288003770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 681288003771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 681288003772 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 681288003773 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 681288003774 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288003775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288003776 catalytic residue [active] 681288003777 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 681288003778 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 681288003779 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 681288003780 putative active site [active] 681288003781 catalytic site [active] 681288003782 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 681288003783 putative active site [active] 681288003784 catalytic site [active] 681288003785 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 681288003786 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 681288003787 Walker A/P-loop; other site 681288003788 ATP binding site [chemical binding]; other site 681288003789 Q-loop/lid; other site 681288003790 ABC transporter signature motif; other site 681288003791 Walker B; other site 681288003792 D-loop; other site 681288003793 H-loop/switch region; other site 681288003794 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 681288003795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 681288003796 Histidine kinase; Region: HisKA_3; pfam07730 681288003797 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 681288003798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 681288003799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288003800 active site 681288003801 phosphorylation site [posttranslational modification] 681288003802 intermolecular recognition site; other site 681288003803 dimerization interface [polypeptide binding]; other site 681288003804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 681288003805 DNA binding residues [nucleotide binding] 681288003806 dimerization interface [polypeptide binding]; other site 681288003807 Staphylococcal nuclease homologues; Region: SNc; smart00318 681288003808 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 681288003809 Catalytic site; other site 681288003810 AAA domain; Region: AAA_11; pfam13086 681288003811 aspartate kinase; Reviewed; Region: PRK09034 681288003812 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 681288003813 putative catalytic residues [active] 681288003814 putative nucleotide binding site [chemical binding]; other site 681288003815 putative aspartate binding site [chemical binding]; other site 681288003816 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 681288003817 allosteric regulatory residue; other site 681288003818 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 681288003819 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 681288003820 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 681288003821 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 681288003822 threonine synthase; Reviewed; Region: PRK06721 681288003823 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 681288003824 homodimer interface [polypeptide binding]; other site 681288003825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288003826 catalytic residue [active] 681288003827 homoserine kinase; Provisional; Region: PRK01212 681288003828 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 681288003829 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 681288003830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288003831 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 681288003832 active site 681288003833 motif I; other site 681288003834 motif II; other site 681288003835 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 681288003836 lysine transporter; Provisional; Region: PRK10836 681288003837 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 681288003838 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 681288003839 tetramer interface [polypeptide binding]; other site 681288003840 heme binding pocket [chemical binding]; other site 681288003841 NADPH binding site [chemical binding]; other site 681288003842 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 681288003843 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 681288003844 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 681288003845 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 681288003846 active site 681288003847 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 681288003848 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 681288003849 LexA repressor; Validated; Region: PRK00215 681288003850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 681288003851 putative DNA binding site [nucleotide binding]; other site 681288003852 putative Zn2+ binding site [ion binding]; other site 681288003853 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 681288003854 Catalytic site [active] 681288003855 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 681288003856 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 681288003857 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 681288003858 TPP-binding site [chemical binding]; other site 681288003859 dimer interface [polypeptide binding]; other site 681288003860 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 681288003861 PYR/PP interface [polypeptide binding]; other site 681288003862 dimer interface [polypeptide binding]; other site 681288003863 TPP binding site [chemical binding]; other site 681288003864 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 681288003865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 681288003866 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 681288003867 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 681288003868 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 681288003869 active site 681288003870 metal binding site [ion binding]; metal-binding site 681288003871 DNA binding site [nucleotide binding] 681288003872 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 681288003873 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 681288003874 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 681288003875 Walker A/P-loop; other site 681288003876 ATP binding site [chemical binding]; other site 681288003877 Q-loop/lid; other site 681288003878 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 681288003879 ABC transporter signature motif; other site 681288003880 Walker B; other site 681288003881 D-loop; other site 681288003882 H-loop/switch region; other site 681288003883 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 681288003884 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 681288003885 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 681288003886 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 681288003887 aconitate hydratase; Validated; Region: PRK09277 681288003888 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 681288003889 substrate binding site [chemical binding]; other site 681288003890 ligand binding site [chemical binding]; other site 681288003891 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 681288003892 substrate binding site [chemical binding]; other site 681288003893 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 681288003894 active site 681288003895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 681288003896 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 681288003897 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 681288003898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288003899 ATP binding site [chemical binding]; other site 681288003900 Mg2+ binding site [ion binding]; other site 681288003901 G-X-G motif; other site 681288003902 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 681288003903 anchoring element; other site 681288003904 dimer interface [polypeptide binding]; other site 681288003905 ATP binding site [chemical binding]; other site 681288003906 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 681288003907 active site 681288003908 putative metal-binding site [ion binding]; other site 681288003909 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 681288003910 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 681288003911 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 681288003912 CAP-like domain; other site 681288003913 active site 681288003914 primary dimer interface [polypeptide binding]; other site 681288003915 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288003916 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 681288003917 amino acid carrier protein; Region: agcS; TIGR00835 681288003918 CAT RNA binding domain; Region: CAT_RBD; smart01061 681288003919 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 681288003920 PRD domain; Region: PRD; pfam00874 681288003921 PRD domain; Region: PRD; pfam00874 681288003922 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 681288003923 Domain of unknown function DUF20; Region: UPF0118; pfam01594 681288003924 Predicted integral membrane protein [Function unknown]; Region: COG0392 681288003925 Uncharacterized conserved protein [Function unknown]; Region: COG2898 681288003926 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 681288003927 methionine sulfoxide reductase A; Provisional; Region: PRK14054 681288003928 Transcriptional regulator [Transcription]; Region: LytR; COG1316 681288003929 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 681288003930 active site 1 [active] 681288003931 dimer interface [polypeptide binding]; other site 681288003932 hexamer interface [polypeptide binding]; other site 681288003933 active site 2 [active] 681288003934 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 681288003935 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 681288003936 active site 681288003937 DNA binding site [nucleotide binding] 681288003938 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 681288003939 prephenate dehydrogenase; Validated; Region: PRK06545 681288003940 prephenate dehydrogenase; Validated; Region: PRK08507 681288003941 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 681288003942 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 681288003943 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 681288003944 putative oligomer interface [polypeptide binding]; other site 681288003945 putative active site [active] 681288003946 metal binding site [ion binding]; metal-binding site 681288003947 SAAV_1347 681288003948 SAAV_1348 681288003949 anthranilate synthase component I; Provisional; Region: PRK13567 681288003950 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 681288003951 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 681288003952 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 681288003953 Glutamine amidotransferase class-I; Region: GATase; pfam00117 681288003954 glutamine binding [chemical binding]; other site 681288003955 catalytic triad [active] 681288003956 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 681288003957 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 681288003958 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 681288003959 active site 681288003960 ribulose/triose binding site [chemical binding]; other site 681288003961 phosphate binding site [ion binding]; other site 681288003962 substrate (anthranilate) binding pocket [chemical binding]; other site 681288003963 product (indole) binding pocket [chemical binding]; other site 681288003964 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 681288003965 active site 681288003966 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 681288003967 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 681288003968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288003969 catalytic residue [active] 681288003970 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 681288003971 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 681288003972 substrate binding site [chemical binding]; other site 681288003973 active site 681288003974 catalytic residues [active] 681288003975 heterodimer interface [polypeptide binding]; other site 681288003976 FemAB family; Region: FemAB; pfam02388 681288003977 FlxA-like protein; Region: FlxA; pfam14282 681288003978 FemAB family; Region: FemAB; pfam02388 681288003979 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 681288003980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288003981 active site 681288003982 motif I; other site 681288003983 motif II; other site 681288003984 SWIM zinc finger; Region: SWIM; pfam04434 681288003985 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 681288003986 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 681288003987 Walker A/P-loop; other site 681288003988 ATP binding site [chemical binding]; other site 681288003989 Q-loop/lid; other site 681288003990 ABC transporter signature motif; other site 681288003991 Walker B; other site 681288003992 D-loop; other site 681288003993 H-loop/switch region; other site 681288003994 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 681288003995 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 681288003996 Walker A/P-loop; other site 681288003997 ATP binding site [chemical binding]; other site 681288003998 Q-loop/lid; other site 681288003999 ABC transporter signature motif; other site 681288004000 Walker B; other site 681288004001 D-loop; other site 681288004002 H-loop/switch region; other site 681288004003 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 681288004004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288004005 dimer interface [polypeptide binding]; other site 681288004006 conserved gate region; other site 681288004007 putative PBP binding loops; other site 681288004008 ABC-ATPase subunit interface; other site 681288004009 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 681288004010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288004011 dimer interface [polypeptide binding]; other site 681288004012 conserved gate region; other site 681288004013 putative PBP binding loops; other site 681288004014 ABC-ATPase subunit interface; other site 681288004015 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 681288004016 oligoendopeptidase F; Region: pepF; TIGR00181 681288004017 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 681288004018 active site 681288004019 Zn binding site [ion binding]; other site 681288004020 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 681288004021 PhoU domain; Region: PhoU; pfam01895 681288004022 PhoU domain; Region: PhoU; pfam01895 681288004023 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 681288004024 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 681288004025 Walker A/P-loop; other site 681288004026 ATP binding site [chemical binding]; other site 681288004027 Q-loop/lid; other site 681288004028 ABC transporter signature motif; other site 681288004029 Walker B; other site 681288004030 D-loop; other site 681288004031 H-loop/switch region; other site 681288004032 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 681288004033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288004034 dimer interface [polypeptide binding]; other site 681288004035 conserved gate region; other site 681288004036 putative PBP binding loops; other site 681288004037 ABC-ATPase subunit interface; other site 681288004038 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 681288004039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288004040 dimer interface [polypeptide binding]; other site 681288004041 conserved gate region; other site 681288004042 ABC-ATPase subunit interface; other site 681288004043 phosphate binding protein; Region: ptsS_2; TIGR02136 681288004044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 681288004045 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 681288004046 S1 domain; Region: S1_2; pfam13509 681288004047 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 681288004048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 681288004049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 681288004050 ABC transporter; Region: ABC_tran_2; pfam12848 681288004051 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 681288004052 SAAV_1375 681288004053 aspartate kinase; Reviewed; Region: PRK06635 681288004054 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 681288004055 putative nucleotide binding site [chemical binding]; other site 681288004056 putative catalytic residues [active] 681288004057 putative Mg ion binding site [ion binding]; other site 681288004058 putative aspartate binding site [chemical binding]; other site 681288004059 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 681288004060 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 681288004061 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 681288004062 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 681288004063 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 681288004064 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 681288004065 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 681288004066 dimer interface [polypeptide binding]; other site 681288004067 active site 681288004068 catalytic residue [active] 681288004069 dihydrodipicolinate reductase; Provisional; Region: PRK00048 681288004070 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 681288004071 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 681288004072 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 681288004073 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 681288004074 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 681288004075 active site 681288004076 trimer interface [polypeptide binding]; other site 681288004077 substrate binding site [chemical binding]; other site 681288004078 CoA binding site [chemical binding]; other site 681288004079 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 681288004080 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 681288004081 metal binding site [ion binding]; metal-binding site 681288004082 dimer interface [polypeptide binding]; other site 681288004083 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 681288004084 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 681288004085 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288004086 catalytic residue [active] 681288004087 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 681288004088 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 681288004089 active site 681288004090 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288004091 substrate binding site [chemical binding]; other site 681288004092 catalytic residues [active] 681288004093 dimer interface [polypeptide binding]; other site 681288004094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288004095 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288004096 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 681288004097 DNA-binding site [nucleotide binding]; DNA binding site 681288004098 RNA-binding motif; other site 681288004099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 681288004100 acylphosphatase; Provisional; Region: PRK14431 681288004101 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 681288004102 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 681288004103 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 681288004104 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 681288004105 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 681288004106 metal ion-dependent adhesion site (MIDAS); other site 681288004107 MoxR-like ATPases [General function prediction only]; Region: COG0714 681288004108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288004109 Walker A motif; other site 681288004110 ATP binding site [chemical binding]; other site 681288004111 Walker B motif; other site 681288004112 arginine finger; other site 681288004113 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 681288004114 active site 681288004115 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 681288004116 active site 681288004117 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 681288004118 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 681288004119 E3 interaction surface; other site 681288004120 lipoyl attachment site [posttranslational modification]; other site 681288004121 e3 binding domain; Region: E3_binding; pfam02817 681288004122 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 681288004123 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 681288004124 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 681288004125 TPP-binding site [chemical binding]; other site 681288004126 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 681288004127 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 681288004128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 681288004129 HAMP domain; Region: HAMP; pfam00672 681288004130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288004131 dimer interface [polypeptide binding]; other site 681288004132 phosphorylation site [posttranslational modification] 681288004133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288004134 ATP binding site [chemical binding]; other site 681288004135 Mg2+ binding site [ion binding]; other site 681288004136 G-X-G motif; other site 681288004137 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288004138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288004139 active site 681288004140 phosphorylation site [posttranslational modification] 681288004141 intermolecular recognition site; other site 681288004142 dimerization interface [polypeptide binding]; other site 681288004143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288004144 DNA binding site [nucleotide binding] 681288004145 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 681288004146 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 681288004147 active site 681288004148 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 681288004149 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 681288004150 active site 681288004151 homodimer interface [polypeptide binding]; other site 681288004152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288004153 Coenzyme A binding pocket [chemical binding]; other site 681288004154 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 681288004155 C-terminal peptidase (prc); Region: prc; TIGR00225 681288004156 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 681288004157 protein binding site [polypeptide binding]; other site 681288004158 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 681288004159 Catalytic dyad [active] 681288004160 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 681288004161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 681288004162 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 681288004163 HPr interaction site; other site 681288004164 glycerol kinase (GK) interaction site [polypeptide binding]; other site 681288004165 active site 681288004166 phosphorylation site [posttranslational modification] 681288004167 methionine sulfoxide reductase B; Provisional; Region: PRK00222 681288004168 SelR domain; Region: SelR; pfam01641 681288004169 methionine sulfoxide reductase A; Provisional; Region: PRK13014 681288004170 EDD domain protein, DegV family; Region: DegV; TIGR00762 681288004171 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 681288004172 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 681288004173 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 681288004174 folate binding site [chemical binding]; other site 681288004175 NADP+ binding site [chemical binding]; other site 681288004176 thymidylate synthase; Region: thym_sym; TIGR03284 681288004177 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 681288004178 dimerization interface [polypeptide binding]; other site 681288004179 active site 681288004180 Disulphide isomerase; Region: Disulph_isomer; pfam06491 681288004181 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 681288004182 Virulence factor; Region: Virulence_fact; pfam13769 681288004183 HEAT repeats; Region: HEAT_2; pfam13646 681288004184 HEAT repeat; Region: HEAT; pfam02985 681288004185 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 681288004186 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 681288004187 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 681288004188 RNA/DNA hybrid binding site [nucleotide binding]; other site 681288004189 active site 681288004190 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288004191 GA module; Region: GA; smart00844 681288004192 GA module; Region: GA; smart00844 681288004193 GA module; Region: GA; smart00844 681288004194 GA module; Region: GA; smart00844 681288004195 GA module; Region: GA; smart00844 681288004196 GA module; Region: GA; smart00844 681288004197 GA module; Region: GA; smart00844 681288004198 GA module; Region: GA; smart00844 681288004199 GA module; Region: GA; smart00844 681288004200 GA module; Region: GA; smart00844 681288004201 GA module; Region: GA; smart00844 681288004202 GA module; Region: GA; smart00844 681288004203 GA module; Region: GA; smart00844 681288004204 Predicted membrane protein [Function unknown]; Region: COG1511 681288004205 GA module; Region: GA; smart00844 681288004206 GA module; Region: GA; pfam01468 681288004207 GA module; Region: GA; smart00844 681288004208 GA module; Region: GA; smart00844 681288004209 GA module; Region: GA; smart00844 681288004210 GA module; Region: GA; pfam01468 681288004211 GA module; Region: GA; smart00844 681288004212 GA module; Region: GA; smart00844 681288004213 GA module; Region: GA; smart00844 681288004214 GA module; Region: GA; smart00844 681288004215 GA module; Region: GA; smart00844 681288004216 GA module; Region: GA; smart00844 681288004217 GA module; Region: GA; smart00844 681288004218 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 681288004219 GA module; Region: GA; pfam01468 681288004220 GA module; Region: GA; smart00844 681288004221 GA module; Region: GA; smart00844 681288004222 GA module; Region: GA; smart00844 681288004223 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 681288004224 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 681288004225 GA module; Region: GA; smart00844 681288004226 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004227 GA module; Region: GA; smart00844 681288004228 GA module; Region: GA; smart00844 681288004229 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004230 GA module; Region: GA; smart00844 681288004231 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004232 GA module; Region: GA; smart00844 681288004233 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004234 GA module; Region: GA; smart00844 681288004235 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004236 GA module; Region: GA; smart00844 681288004237 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004238 GA module; Region: GA; smart00844 681288004239 GA module; Region: GA; smart00844 681288004240 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004241 GA module; Region: GA; smart00844 681288004242 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 681288004243 Amino acid permease; Region: AA_permease_2; pfam13520 681288004244 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 681288004245 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 681288004246 tetramer interface [polypeptide binding]; other site 681288004247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288004248 catalytic residue [active] 681288004249 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 681288004250 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 681288004251 hexamer interface [polypeptide binding]; other site 681288004252 ligand binding site [chemical binding]; other site 681288004253 putative active site [active] 681288004254 NAD(P) binding site [chemical binding]; other site 681288004255 5'-3' exonuclease; Region: 53EXOc; smart00475 681288004256 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 681288004257 active site 681288004258 metal binding site 1 [ion binding]; metal-binding site 681288004259 putative 5' ssDNA interaction site; other site 681288004260 metal binding site 3; metal-binding site 681288004261 metal binding site 2 [ion binding]; metal-binding site 681288004262 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 681288004263 putative DNA binding site [nucleotide binding]; other site 681288004264 putative metal binding site [ion binding]; other site 681288004265 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 681288004266 Dynamin family; Region: Dynamin_N; pfam00350 681288004267 G1 box; other site 681288004268 GTP/Mg2+ binding site [chemical binding]; other site 681288004269 G2 box; other site 681288004270 Switch I region; other site 681288004271 G3 box; other site 681288004272 Switch II region; other site 681288004273 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 681288004274 G4 box; other site 681288004275 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 681288004276 Dynamin family; Region: Dynamin_N; pfam00350 681288004277 G1 box; other site 681288004278 GTP/Mg2+ binding site [chemical binding]; other site 681288004279 G2 box; other site 681288004280 Switch I region; other site 681288004281 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 681288004282 G3 box; other site 681288004283 Switch II region; other site 681288004284 GTP/Mg2+ binding site [chemical binding]; other site 681288004285 G4 box; other site 681288004286 G5 box; other site 681288004287 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 681288004288 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 681288004289 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 681288004290 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 681288004291 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 681288004292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 681288004293 cell division protein GpsB; Provisional; Region: PRK14127 681288004294 DivIVA domain; Region: DivI1A_domain; TIGR03544 681288004295 hypothetical protein; Provisional; Region: PRK13660 681288004296 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 681288004297 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 681288004298 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 681288004299 Transglycosylase; Region: Transgly; pfam00912 681288004300 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 681288004301 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 681288004302 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 681288004303 minor groove reading motif; other site 681288004304 helix-hairpin-helix signature motif; other site 681288004305 substrate binding pocket [chemical binding]; other site 681288004306 active site 681288004307 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 681288004308 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 681288004309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 681288004310 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 681288004311 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 681288004312 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 681288004313 putative dimer interface [polypeptide binding]; other site 681288004314 putative anticodon binding site; other site 681288004315 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 681288004316 homodimer interface [polypeptide binding]; other site 681288004317 motif 1; other site 681288004318 motif 2; other site 681288004319 active site 681288004320 motif 3; other site 681288004321 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 681288004322 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 681288004323 active site 681288004324 catalytic site [active] 681288004325 substrate binding site [chemical binding]; other site 681288004326 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 681288004327 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 681288004328 Biotin operon repressor [Transcription]; Region: BirA; COG1654 681288004329 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 681288004330 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 681288004331 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 681288004332 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 681288004333 active site 681288004334 NTP binding site [chemical binding]; other site 681288004335 metal binding triad [ion binding]; metal-binding site 681288004336 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 681288004337 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 681288004338 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 681288004339 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 681288004340 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 681288004341 homodimer interface [polypeptide binding]; other site 681288004342 metal binding site [ion binding]; metal-binding site 681288004343 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 681288004344 Predicted membrane protein [Function unknown]; Region: COG4347 681288004345 Uncharacterized conserved protein [Function unknown]; Region: COG5582 681288004346 UPF0302 domain; Region: UPF0302; pfam08864 681288004347 A short protein domain of unknown function; Region: IDEAL; smart00914 681288004348 TPR repeat; Region: TPR_11; pfam13414 681288004349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288004350 binding surface 681288004351 TPR motif; other site 681288004352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288004353 TPR motif; other site 681288004354 binding surface 681288004355 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 681288004356 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 681288004357 hinge; other site 681288004358 active site 681288004359 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 681288004360 active site 681288004361 NAD binding site [chemical binding]; other site 681288004362 metal binding site [ion binding]; metal-binding site 681288004363 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 681288004364 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 681288004365 Tetramer interface [polypeptide binding]; other site 681288004366 active site 681288004367 FMN-binding site [chemical binding]; other site 681288004368 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 681288004369 active site 681288004370 multimer interface [polypeptide binding]; other site 681288004371 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 681288004372 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 681288004373 substrate binding pocket [chemical binding]; other site 681288004374 chain length determination region; other site 681288004375 substrate-Mg2+ binding site; other site 681288004376 catalytic residues [active] 681288004377 aspartate-rich region 1; other site 681288004378 active site lid residues [active] 681288004379 aspartate-rich region 2; other site 681288004380 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 681288004381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288004382 S-adenosylmethionine binding site [chemical binding]; other site 681288004383 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 681288004384 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 681288004385 IHF dimer interface [polypeptide binding]; other site 681288004386 IHF - DNA interface [nucleotide binding]; other site 681288004387 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 681288004388 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 681288004389 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 681288004390 GTP-binding protein Der; Reviewed; Region: PRK00093 681288004391 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 681288004392 G1 box; other site 681288004393 GTP/Mg2+ binding site [chemical binding]; other site 681288004394 Switch I region; other site 681288004395 G2 box; other site 681288004396 Switch II region; other site 681288004397 G3 box; other site 681288004398 G4 box; other site 681288004399 G5 box; other site 681288004400 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 681288004401 G1 box; other site 681288004402 GTP/Mg2+ binding site [chemical binding]; other site 681288004403 Switch I region; other site 681288004404 G2 box; other site 681288004405 G3 box; other site 681288004406 Switch II region; other site 681288004407 G4 box; other site 681288004408 G5 box; other site 681288004409 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 681288004410 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 681288004411 RNA binding site [nucleotide binding]; other site 681288004412 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 681288004413 RNA binding site [nucleotide binding]; other site 681288004414 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 681288004415 RNA binding site [nucleotide binding]; other site 681288004416 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 681288004417 RNA binding site [nucleotide binding]; other site 681288004418 cytidylate kinase; Provisional; Region: cmk; PRK00023 681288004419 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 681288004420 CMP-binding site; other site 681288004421 The sites determining sugar specificity; other site 681288004422 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 681288004423 active site 681288004424 homotetramer interface [polypeptide binding]; other site 681288004425 homodimer interface [polypeptide binding]; other site 681288004426 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 681288004427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 681288004428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288004429 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 681288004430 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 681288004431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288004432 ATP binding site [chemical binding]; other site 681288004433 putative Mg++ binding site [ion binding]; other site 681288004434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288004435 nucleotide binding region [chemical binding]; other site 681288004436 ATP-binding site [chemical binding]; other site 681288004437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 681288004438 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 681288004439 Predicted membrane protein [Function unknown]; Region: COG3601 681288004440 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 681288004441 SAAV_1473 681288004442 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 681288004443 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 681288004444 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 681288004445 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 681288004446 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 681288004447 dimerization interface [polypeptide binding]; other site 681288004448 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 681288004449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288004450 dimer interface [polypeptide binding]; other site 681288004451 phosphorylation site [posttranslational modification] 681288004452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288004453 ATP binding site [chemical binding]; other site 681288004454 Mg2+ binding site [ion binding]; other site 681288004455 G-X-G motif; other site 681288004456 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288004457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288004458 active site 681288004459 phosphorylation site [posttranslational modification] 681288004460 intermolecular recognition site; other site 681288004461 dimerization interface [polypeptide binding]; other site 681288004462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288004463 DNA binding site [nucleotide binding] 681288004464 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 681288004465 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288004466 RNA binding surface [nucleotide binding]; other site 681288004467 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 681288004468 active site 681288004469 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 681288004470 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 681288004471 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 681288004472 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 681288004473 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 681288004474 active site 681288004475 Int/Topo IB signature motif; other site 681288004476 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 681288004477 metal binding site 2 [ion binding]; metal-binding site 681288004478 putative DNA binding helix; other site 681288004479 metal binding site 1 [ion binding]; metal-binding site 681288004480 dimer interface [polypeptide binding]; other site 681288004481 structural Zn2+ binding site [ion binding]; other site 681288004482 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 681288004483 dimer interface [polypeptide binding]; other site 681288004484 ADP-ribose binding site [chemical binding]; other site 681288004485 active site 681288004486 nudix motif; other site 681288004487 metal binding site [ion binding]; metal-binding site 681288004488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288004489 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 681288004490 active site 681288004491 catalytic tetrad [active] 681288004492 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 681288004493 classical (c) SDRs; Region: SDR_c; cd05233 681288004494 NAD(P) binding site [chemical binding]; other site 681288004495 active site 681288004496 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 681288004497 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 681288004498 ribonuclease Z; Region: RNase_Z; TIGR02651 681288004499 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 681288004500 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 681288004501 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 681288004502 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 681288004503 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 681288004504 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 681288004505 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 681288004506 Ca binding site [ion binding]; other site 681288004507 active site 681288004508 catalytic site [active] 681288004509 Transcriptional regulators [Transcription]; Region: PurR; COG1609 681288004510 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 681288004511 DNA binding site [nucleotide binding] 681288004512 domain linker motif; other site 681288004513 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 681288004514 putative ligand binding site [chemical binding]; other site 681288004515 putative dimerization interface [polypeptide binding]; other site 681288004516 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 681288004517 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 681288004518 H+ Antiporter protein; Region: 2A0121; TIGR00900 681288004519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288004520 putative substrate translocation pore; other site 681288004521 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 681288004522 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 681288004523 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 681288004524 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 681288004525 peptidase T-like protein; Region: PepT-like; TIGR01883 681288004526 metal binding site [ion binding]; metal-binding site 681288004527 putative dimer interface [polypeptide binding]; other site 681288004528 Predicted membrane protein [Function unknown]; Region: COG4129 681288004529 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 681288004530 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 681288004531 Disulphide isomerase; Region: Disulph_isomer; pfam06491 681288004532 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 681288004533 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 681288004534 E3 interaction surface; other site 681288004535 lipoyl attachment site [posttranslational modification]; other site 681288004536 e3 binding domain; Region: E3_binding; pfam02817 681288004537 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 681288004538 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 681288004539 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 681288004540 alpha subunit interface [polypeptide binding]; other site 681288004541 TPP binding site [chemical binding]; other site 681288004542 heterodimer interface [polypeptide binding]; other site 681288004543 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 681288004544 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 681288004545 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 681288004546 tetramer interface [polypeptide binding]; other site 681288004547 TPP-binding site [chemical binding]; other site 681288004548 heterodimer interface [polypeptide binding]; other site 681288004549 phosphorylation loop region [posttranslational modification] 681288004550 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 681288004551 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 681288004552 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288004553 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 681288004554 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 681288004555 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 681288004556 Walker A/P-loop; other site 681288004557 ATP binding site [chemical binding]; other site 681288004558 Q-loop/lid; other site 681288004559 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 681288004560 ABC transporter signature motif; other site 681288004561 Walker B; other site 681288004562 D-loop; other site 681288004563 H-loop/switch region; other site 681288004564 arginine repressor; Provisional; Region: PRK04280 681288004565 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 681288004566 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 681288004567 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 681288004568 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 681288004569 substrate binding pocket [chemical binding]; other site 681288004570 chain length determination region; other site 681288004571 substrate-Mg2+ binding site; other site 681288004572 catalytic residues [active] 681288004573 aspartate-rich region 1; other site 681288004574 active site lid residues [active] 681288004575 aspartate-rich region 2; other site 681288004576 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 681288004577 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 681288004578 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 681288004579 generic binding surface II; other site 681288004580 generic binding surface I; other site 681288004581 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 681288004582 putative RNA binding site [nucleotide binding]; other site 681288004583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 681288004584 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 681288004585 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 681288004586 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 681288004587 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 681288004588 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 681288004589 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 681288004590 carboxyltransferase (CT) interaction site; other site 681288004591 biotinylation site [posttranslational modification]; other site 681288004592 elongation factor P; Validated; Region: PRK00529 681288004593 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 681288004594 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 681288004595 RNA binding site [nucleotide binding]; other site 681288004596 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 681288004597 RNA binding site [nucleotide binding]; other site 681288004598 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 681288004599 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 681288004600 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 681288004601 active site 681288004602 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 681288004603 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 681288004604 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 681288004605 active site residue [active] 681288004606 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 681288004607 tetramer interface [polypeptide binding]; other site 681288004608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288004609 catalytic residue [active] 681288004610 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 681288004611 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 681288004612 tetramer interface [polypeptide binding]; other site 681288004613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288004614 catalytic residue [active] 681288004615 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 681288004616 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 681288004617 SAAV_1530 681288004618 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 681288004619 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 681288004620 ADP binding site [chemical binding]; other site 681288004621 magnesium binding site [ion binding]; other site 681288004622 putative shikimate binding site; other site 681288004623 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 681288004624 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 681288004625 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 681288004626 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 681288004627 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 681288004628 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 681288004629 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 681288004630 Type II/IV secretion system protein; Region: T2SE; pfam00437 681288004631 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 681288004632 Walker A motif; other site 681288004633 ATP binding site [chemical binding]; other site 681288004634 Walker B motif; other site 681288004635 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 681288004636 Uncharacterized conserved protein [Function unknown]; Region: COG0011 681288004637 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 681288004638 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 681288004639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 681288004640 Rhomboid family; Region: Rhomboid; pfam01694 681288004641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288004642 binding surface 681288004643 TPR motif; other site 681288004644 Tetratricopeptide repeat; Region: TPR_16; pfam13432 681288004645 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 681288004646 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 681288004647 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 681288004648 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 681288004649 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 681288004650 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 681288004651 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 681288004652 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 681288004653 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 681288004654 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 681288004655 metal binding site 2 [ion binding]; metal-binding site 681288004656 putative DNA binding helix; other site 681288004657 metal binding site 1 [ion binding]; metal-binding site 681288004658 dimer interface [polypeptide binding]; other site 681288004659 structural Zn2+ binding site [ion binding]; other site 681288004660 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 681288004661 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288004662 ABC-ATPase subunit interface; other site 681288004663 dimer interface [polypeptide binding]; other site 681288004664 putative PBP binding regions; other site 681288004665 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 681288004666 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 681288004667 endonuclease IV; Provisional; Region: PRK01060 681288004668 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 681288004669 AP (apurinic/apyrimidinic) site pocket; other site 681288004670 DNA interaction; other site 681288004671 Metal-binding active site; metal-binding site 681288004672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 681288004673 DEAD-like helicases superfamily; Region: DEXDc; smart00487 681288004674 ATP binding site [chemical binding]; other site 681288004675 putative Mg++ binding site [ion binding]; other site 681288004676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288004677 nucleotide binding region [chemical binding]; other site 681288004678 ATP-binding site [chemical binding]; other site 681288004679 Uncharacterized conserved protein [Function unknown]; Region: COG0327 681288004680 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 681288004681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 681288004682 Uncharacterized conserved protein [Function unknown]; Region: COG0327 681288004683 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 681288004684 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 681288004685 Family of unknown function (DUF633); Region: DUF633; pfam04816 681288004686 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 681288004687 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 681288004688 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 681288004689 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 681288004690 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 681288004691 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 681288004692 DNA binding residues [nucleotide binding] 681288004693 DNA primase, catalytic core; Region: dnaG; TIGR01391 681288004694 CHC2 zinc finger; Region: zf-CHC2; pfam01807 681288004695 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 681288004696 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 681288004697 active site 681288004698 metal binding site [ion binding]; metal-binding site 681288004699 interdomain interaction site; other site 681288004700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 681288004701 HTH domain; Region: HTH_11; cl17392 681288004702 FOG: CBS domain [General function prediction only]; Region: COG0517 681288004703 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 681288004704 glycyl-tRNA synthetase; Provisional; Region: PRK04173 681288004705 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 681288004706 motif 1; other site 681288004707 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 681288004708 active site 681288004709 motif 2; other site 681288004710 motif 3; other site 681288004711 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 681288004712 anticodon binding site; other site 681288004713 DNA repair protein RecO; Region: reco; TIGR00613 681288004714 Recombination protein O N terminal; Region: RecO_N; pfam11967 681288004715 Recombination protein O C terminal; Region: RecO_C; pfam02565 681288004716 GTPase Era; Reviewed; Region: era; PRK00089 681288004717 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 681288004718 G1 box; other site 681288004719 GTP/Mg2+ binding site [chemical binding]; other site 681288004720 Switch I region; other site 681288004721 G2 box; other site 681288004722 Switch II region; other site 681288004723 G3 box; other site 681288004724 G4 box; other site 681288004725 G5 box; other site 681288004726 KH domain; Region: KH_2; pfam07650 681288004727 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 681288004728 active site 681288004729 catalytic motif [active] 681288004730 Zn binding site [ion binding]; other site 681288004731 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 681288004732 metal-binding heat shock protein; Provisional; Region: PRK00016 681288004733 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 681288004734 PhoH-like protein; Region: PhoH; pfam02562 681288004735 hypothetical protein; Provisional; Region: PRK13665 681288004736 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 681288004737 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 681288004738 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 681288004739 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 681288004740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288004741 FeS/SAM binding site; other site 681288004742 TRAM domain; Region: TRAM; cl01282 681288004743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 681288004744 RNA methyltransferase, RsmE family; Region: TIGR00046 681288004745 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 681288004746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288004747 S-adenosylmethionine binding site [chemical binding]; other site 681288004748 chaperone protein DnaJ; Provisional; Region: PRK14280 681288004749 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 681288004750 HSP70 interaction site [polypeptide binding]; other site 681288004751 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 681288004752 substrate binding site [polypeptide binding]; other site 681288004753 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 681288004754 Zn binding sites [ion binding]; other site 681288004755 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 681288004756 dimer interface [polypeptide binding]; other site 681288004757 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 681288004758 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 681288004759 nucleotide binding site [chemical binding]; other site 681288004760 NEF interaction site [polypeptide binding]; other site 681288004761 SBD interface [polypeptide binding]; other site 681288004762 heat shock protein GrpE; Provisional; Region: PRK14140 681288004763 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 681288004764 dimer interface [polypeptide binding]; other site 681288004765 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 681288004766 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 681288004767 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 681288004768 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 681288004769 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 681288004770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288004771 FeS/SAM binding site; other site 681288004772 HemN C-terminal domain; Region: HemN_C; pfam06969 681288004773 GTP-binding protein LepA; Provisional; Region: PRK05433 681288004774 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 681288004775 G1 box; other site 681288004776 putative GEF interaction site [polypeptide binding]; other site 681288004777 GTP/Mg2+ binding site [chemical binding]; other site 681288004778 Switch I region; other site 681288004779 G2 box; other site 681288004780 G3 box; other site 681288004781 Switch II region; other site 681288004782 G4 box; other site 681288004783 G5 box; other site 681288004784 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 681288004785 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 681288004786 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 681288004787 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 681288004788 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 681288004789 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 681288004790 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 681288004791 Competence protein; Region: Competence; pfam03772 681288004792 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 681288004793 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 681288004794 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 681288004795 catalytic motif [active] 681288004796 Zn binding site [ion binding]; other site 681288004797 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 681288004798 Helix-hairpin-helix motif; Region: HHH; pfam00633 681288004799 Methyltransferase domain; Region: Methyltransf_31; pfam13847 681288004800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288004801 S-adenosylmethionine binding site [chemical binding]; other site 681288004802 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 681288004803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 681288004804 Zn2+ binding site [ion binding]; other site 681288004805 Mg2+ binding site [ion binding]; other site 681288004806 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 681288004807 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 681288004808 active site 681288004809 (T/H)XGH motif; other site 681288004810 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 681288004811 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 681288004812 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 681288004813 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 681288004814 shikimate binding site; other site 681288004815 NAD(P) binding site [chemical binding]; other site 681288004816 GTPase YqeH; Provisional; Region: PRK13796 681288004817 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 681288004818 GTP/Mg2+ binding site [chemical binding]; other site 681288004819 G4 box; other site 681288004820 G5 box; other site 681288004821 G1 box; other site 681288004822 Switch I region; other site 681288004823 G2 box; other site 681288004824 G3 box; other site 681288004825 Switch II region; other site 681288004826 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 681288004827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288004828 active site 681288004829 motif I; other site 681288004830 motif II; other site 681288004831 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 681288004832 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 681288004833 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288004834 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288004835 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 681288004836 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 681288004837 putative active site [active] 681288004838 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 681288004839 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 681288004840 ATP-grasp domain; Region: ATP-grasp_4; cl17255 681288004841 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 681288004842 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 681288004843 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 681288004844 carboxyltransferase (CT) interaction site; other site 681288004845 biotinylation site [posttranslational modification]; other site 681288004846 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 681288004847 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 681288004848 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 681288004849 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 681288004850 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 681288004851 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 681288004852 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 681288004853 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 681288004854 Sugar specificity; other site 681288004855 Pyrimidine base specificity; other site 681288004856 ATP-binding site [chemical binding]; other site 681288004857 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 681288004858 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 681288004859 Peptidase family U32; Region: Peptidase_U32; pfam01136 681288004860 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 681288004861 Peptidase family U32; Region: Peptidase_U32; pfam01136 681288004862 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 681288004863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288004864 S-adenosylmethionine binding site [chemical binding]; other site 681288004865 hypothetical protein; Provisional; Region: PRK13678 681288004866 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 681288004867 hypothetical protein; Provisional; Region: PRK05473 681288004868 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 681288004869 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 681288004870 motif 1; other site 681288004871 active site 681288004872 motif 2; other site 681288004873 motif 3; other site 681288004874 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 681288004875 DHHA1 domain; Region: DHHA1; pfam02272 681288004876 SAAV_1611 681288004877 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 681288004878 AAA domain; Region: AAA_30; pfam13604 681288004879 Family description; Region: UvrD_C_2; pfam13538 681288004880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288004881 binding surface 681288004882 TPR motif; other site 681288004883 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 681288004884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288004885 binding surface 681288004886 TPR motif; other site 681288004887 TPR repeat; Region: TPR_11; pfam13414 681288004888 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 681288004889 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 681288004890 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 681288004891 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 681288004892 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288004893 catalytic residue [active] 681288004894 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 681288004895 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 681288004896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 681288004897 Predicted transcriptional regulator [Transcription]; Region: COG1959 681288004898 Transcriptional regulator; Region: Rrf2; pfam02082 681288004899 recombination factor protein RarA; Reviewed; Region: PRK13342 681288004900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288004901 Walker A motif; other site 681288004902 ATP binding site [chemical binding]; other site 681288004903 Walker B motif; other site 681288004904 arginine finger; other site 681288004905 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 681288004906 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 681288004907 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 681288004908 putative ATP binding site [chemical binding]; other site 681288004909 putative substrate interface [chemical binding]; other site 681288004910 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 681288004911 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 681288004912 dimer interface [polypeptide binding]; other site 681288004913 anticodon binding site; other site 681288004914 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 681288004915 homodimer interface [polypeptide binding]; other site 681288004916 motif 1; other site 681288004917 active site 681288004918 motif 2; other site 681288004919 GAD domain; Region: GAD; pfam02938 681288004920 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 681288004921 motif 3; other site 681288004922 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 681288004923 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 681288004924 dimer interface [polypeptide binding]; other site 681288004925 motif 1; other site 681288004926 active site 681288004927 motif 2; other site 681288004928 motif 3; other site 681288004929 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 681288004930 anticodon binding site; other site 681288004931 Bacterial SH3 domain homologues; Region: SH3b; smart00287 681288004932 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 681288004933 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 681288004934 active site 681288004935 metal binding site [ion binding]; metal-binding site 681288004936 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 681288004937 putative active site [active] 681288004938 dimerization interface [polypeptide binding]; other site 681288004939 putative tRNAtyr binding site [nucleotide binding]; other site 681288004940 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 681288004941 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 681288004942 Zn2+ binding site [ion binding]; other site 681288004943 Mg2+ binding site [ion binding]; other site 681288004944 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 681288004945 synthetase active site [active] 681288004946 NTP binding site [chemical binding]; other site 681288004947 metal binding site [ion binding]; metal-binding site 681288004948 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 681288004949 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 681288004950 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288004951 active site 681288004952 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 681288004953 DHH family; Region: DHH; pfam01368 681288004954 DHHA1 domain; Region: DHHA1; pfam02272 681288004955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 681288004956 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 681288004957 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 681288004958 Protein export membrane protein; Region: SecD_SecF; cl14618 681288004959 Protein export membrane protein; Region: SecD_SecF; pfam02355 681288004960 Preprotein translocase subunit; Region: YajC; pfam02699 681288004961 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 681288004962 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 681288004963 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 681288004964 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 681288004965 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 681288004966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288004967 Walker A motif; other site 681288004968 ATP binding site [chemical binding]; other site 681288004969 Walker B motif; other site 681288004970 arginine finger; other site 681288004971 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 681288004972 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 681288004973 RuvA N terminal domain; Region: RuvA_N; pfam01330 681288004974 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 681288004975 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 681288004976 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 681288004977 GTPase CgtA; Reviewed; Region: obgE; PRK12297 681288004978 GTP1/OBG; Region: GTP1_OBG; pfam01018 681288004979 Obg GTPase; Region: Obg; cd01898 681288004980 G1 box; other site 681288004981 GTP/Mg2+ binding site [chemical binding]; other site 681288004982 Switch I region; other site 681288004983 G2 box; other site 681288004984 G3 box; other site 681288004985 Switch II region; other site 681288004986 G4 box; other site 681288004987 G5 box; other site 681288004988 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 681288004989 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 681288004990 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 681288004991 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 681288004992 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 681288004993 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 681288004994 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 681288004995 rod shape-determining protein MreC; Region: MreC; pfam04085 681288004996 hypothetical protein; Reviewed; Region: PRK00024 681288004997 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 681288004998 MPN+ (JAMM) motif; other site 681288004999 Zinc-binding site [ion binding]; other site 681288005000 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 681288005001 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 681288005002 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 681288005003 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 681288005004 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288005005 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 681288005006 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 681288005007 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 681288005008 active site 681288005009 HIGH motif; other site 681288005010 nucleotide binding site [chemical binding]; other site 681288005011 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 681288005012 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 681288005013 active site 681288005014 KMSKS motif; other site 681288005015 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 681288005016 tRNA binding surface [nucleotide binding]; other site 681288005017 anticodon binding site; other site 681288005018 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 681288005019 SAAV_1650 681288005020 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 681288005021 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 681288005022 Putative ammonia monooxygenase; Region: AmoA; pfam05145 681288005023 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 681288005024 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 681288005025 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288005026 inhibitor-cofactor binding pocket; inhibition site 681288005027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288005028 catalytic residue [active] 681288005029 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 681288005030 dimer interface [polypeptide binding]; other site 681288005031 active site 681288005032 Schiff base residues; other site 681288005033 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 681288005034 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 681288005035 active site 681288005036 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 681288005037 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 681288005038 domain interfaces; other site 681288005039 active site 681288005040 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 681288005041 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 681288005042 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 681288005043 tRNA; other site 681288005044 putative tRNA binding site [nucleotide binding]; other site 681288005045 putative NADP binding site [chemical binding]; other site 681288005046 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 681288005047 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 681288005048 G1 box; other site 681288005049 GTP/Mg2+ binding site [chemical binding]; other site 681288005050 Switch I region; other site 681288005051 G2 box; other site 681288005052 G3 box; other site 681288005053 Switch II region; other site 681288005054 G4 box; other site 681288005055 G5 box; other site 681288005056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288005057 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288005058 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 681288005059 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 681288005060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288005061 Walker A motif; other site 681288005062 ATP binding site [chemical binding]; other site 681288005063 Walker B motif; other site 681288005064 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 681288005065 trigger factor; Provisional; Region: tig; PRK01490 681288005066 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 681288005067 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 681288005068 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 681288005069 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 681288005070 23S rRNA binding site [nucleotide binding]; other site 681288005071 L21 binding site [polypeptide binding]; other site 681288005072 L13 binding site [polypeptide binding]; other site 681288005073 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 681288005074 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 681288005075 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 681288005076 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 681288005077 SAAV_1669 681288005078 lysine transporter; Provisional; Region: PRK10836 681288005079 SAAV_1671 681288005080 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 681288005081 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 681288005082 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 681288005083 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 681288005084 active site 681288005085 dimer interface [polypeptide binding]; other site 681288005086 motif 1; other site 681288005087 motif 2; other site 681288005088 motif 3; other site 681288005089 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 681288005090 anticodon binding site; other site 681288005091 SAAV_1673 681288005092 primosomal protein DnaI; Reviewed; Region: PRK08939 681288005093 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 681288005094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288005095 Walker A motif; other site 681288005096 ATP binding site [chemical binding]; other site 681288005097 Walker B motif; other site 681288005098 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 681288005099 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 681288005100 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 681288005101 ATP cone domain; Region: ATP-cone; pfam03477 681288005102 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 681288005103 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 681288005104 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 681288005105 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 681288005106 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 681288005107 CoA-binding site [chemical binding]; other site 681288005108 ATP-binding [chemical binding]; other site 681288005109 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 681288005110 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 681288005111 DNA binding site [nucleotide binding] 681288005112 catalytic residue [active] 681288005113 H2TH interface [polypeptide binding]; other site 681288005114 putative catalytic residues [active] 681288005115 turnover-facilitating residue; other site 681288005116 intercalation triad [nucleotide binding]; other site 681288005117 8OG recognition residue [nucleotide binding]; other site 681288005118 putative reading head residues; other site 681288005119 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 681288005120 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 681288005121 DNA polymerase I; Provisional; Region: PRK05755 681288005122 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 681288005123 active site 681288005124 metal binding site 1 [ion binding]; metal-binding site 681288005125 putative 5' ssDNA interaction site; other site 681288005126 metal binding site 3; metal-binding site 681288005127 metal binding site 2 [ion binding]; metal-binding site 681288005128 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 681288005129 putative DNA binding site [nucleotide binding]; other site 681288005130 putative metal binding site [ion binding]; other site 681288005131 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 681288005132 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 681288005133 active site 681288005134 DNA binding site [nucleotide binding] 681288005135 catalytic site [active] 681288005136 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 681288005137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288005138 dimer interface [polypeptide binding]; other site 681288005139 phosphorylation site [posttranslational modification] 681288005140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288005141 ATP binding site [chemical binding]; other site 681288005142 Mg2+ binding site [ion binding]; other site 681288005143 G-X-G motif; other site 681288005144 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288005145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288005146 active site 681288005147 phosphorylation site [posttranslational modification] 681288005148 intermolecular recognition site; other site 681288005149 dimerization interface [polypeptide binding]; other site 681288005150 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288005151 DNA binding site [nucleotide binding] 681288005152 isocitrate dehydrogenase; Reviewed; Region: PRK07006 681288005153 isocitrate dehydrogenase; Validated; Region: PRK07362 681288005154 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 681288005155 dimer interface [polypeptide binding]; other site 681288005156 Citrate synthase; Region: Citrate_synt; pfam00285 681288005157 active site 681288005158 citrylCoA binding site [chemical binding]; other site 681288005159 oxalacetate/citrate binding site [chemical binding]; other site 681288005160 coenzyme A binding site [chemical binding]; other site 681288005161 catalytic triad [active] 681288005162 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 681288005163 pyruvate kinase; Provisional; Region: PRK06354 681288005164 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 681288005165 domain interfaces; other site 681288005166 active site 681288005167 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 681288005168 6-phosphofructokinase; Provisional; Region: PRK03202 681288005169 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 681288005170 active site 681288005171 ADP/pyrophosphate binding site [chemical binding]; other site 681288005172 dimerization interface [polypeptide binding]; other site 681288005173 allosteric effector site; other site 681288005174 fructose-1,6-bisphosphate binding site; other site 681288005175 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 681288005176 Integrase core domain; Region: rve; pfam00665 681288005177 Integrase core domain; Region: rve_3; cl15866 681288005178 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 681288005179 Winged helix-turn helix; Region: HTH_29; pfam13551 681288005180 Homeodomain-like domain; Region: HTH_32; pfam13565 681288005181 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 681288005182 CHAP domain; Region: CHAP; pfam05257 681288005183 Surface antigen [General function prediction only]; Region: COG3942 681288005184 Cenp-F N-terminal domain; Region: Cenp-F_N; pfam10481 681288005185 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 681288005186 AAA-like domain; Region: AAA_10; pfam12846 681288005187 TcpE family; Region: TcpE; pfam12648 681288005188 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 681288005189 Replication initiation factor; Region: Rep_trans; pfam02486 681288005190 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 681288005191 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 681288005192 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 681288005193 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 681288005194 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 681288005195 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 681288005196 Malic enzyme, N-terminal domain; Region: malic; pfam00390 681288005197 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 681288005198 putative NAD(P) binding site [chemical binding]; other site 681288005199 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 681288005200 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 681288005201 active site 681288005202 PHP Thumb interface [polypeptide binding]; other site 681288005203 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 681288005204 generic binding surface I; other site 681288005205 generic binding surface II; other site 681288005206 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 681288005207 DHH family; Region: DHH; pfam01368 681288005208 DHHA1 domain; Region: DHHA1; pfam02272 681288005209 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 681288005210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 681288005211 DNA-binding site [nucleotide binding]; DNA binding site 681288005212 DRTGG domain; Region: DRTGG; pfam07085 681288005213 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 681288005214 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 681288005215 active site 2 [active] 681288005216 active site 1 [active] 681288005217 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 681288005218 Ligand Binding Site [chemical binding]; other site 681288005219 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 681288005220 metal-dependent hydrolase; Provisional; Region: PRK00685 681288005221 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 681288005222 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 681288005223 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 681288005224 active site 681288005225 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 681288005226 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 681288005227 hexamer interface [polypeptide binding]; other site 681288005228 ligand binding site [chemical binding]; other site 681288005229 putative active site [active] 681288005230 NAD(P) binding site [chemical binding]; other site 681288005231 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 681288005232 Ligand Binding Site [chemical binding]; other site 681288005233 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 681288005234 propionate/acetate kinase; Provisional; Region: PRK12379 681288005235 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 681288005236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288005237 S-adenosylmethionine binding site [chemical binding]; other site 681288005238 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 681288005239 dimer interface [polypeptide binding]; other site 681288005240 catalytic triad [active] 681288005241 peroxidatic and resolving cysteines [active] 681288005242 hypothetical protein; Provisional; Region: PRK10621 681288005243 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 681288005244 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 681288005245 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 681288005246 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 681288005247 Ligand Binding Site [chemical binding]; other site 681288005248 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 681288005249 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 681288005250 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288005251 catalytic residue [active] 681288005252 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 681288005253 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 681288005254 GAF domain; Region: GAF_2; pfam13185 681288005255 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 681288005256 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 681288005257 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288005258 RNA binding surface [nucleotide binding]; other site 681288005259 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 681288005260 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 681288005261 active site 681288005262 catalytic site [active] 681288005263 OsmC-like protein; Region: OsmC; cl00767 681288005264 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 681288005265 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288005266 catalytic residue [active] 681288005267 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 681288005268 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 681288005269 ligand binding site [chemical binding]; other site 681288005270 NAD binding site [chemical binding]; other site 681288005271 dimerization interface [polypeptide binding]; other site 681288005272 catalytic site [active] 681288005273 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 681288005274 putative L-serine binding site [chemical binding]; other site 681288005275 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 681288005276 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288005277 motif II; other site 681288005278 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 681288005279 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 681288005280 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288005281 active site turn [active] 681288005282 phosphorylation site [posttranslational modification] 681288005283 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 681288005284 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 681288005285 putative acyl-acceptor binding pocket; other site 681288005286 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 681288005287 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 681288005288 protein binding site [polypeptide binding]; other site 681288005289 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 681288005290 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 681288005291 active site 681288005292 HIGH motif; other site 681288005293 dimer interface [polypeptide binding]; other site 681288005294 KMSKS motif; other site 681288005295 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288005296 RNA binding surface [nucleotide binding]; other site 681288005297 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 681288005298 Transglycosylase; Region: Transgly; pfam00912 681288005299 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 681288005300 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 681288005301 NEAr Transporter domain; Region: NEAT; smart00725 681288005302 NEAr Transporter domain; Region: NEAT; smart00725 681288005303 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 681288005304 heme-binding site [chemical binding]; other site 681288005305 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 681288005306 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 681288005307 Potassium binding sites [ion binding]; other site 681288005308 Cesium cation binding sites [ion binding]; other site 681288005309 acetyl-CoA synthetase; Provisional; Region: PRK04319 681288005310 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 681288005311 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 681288005312 active site 681288005313 acyl-activating enzyme (AAE) consensus motif; other site 681288005314 putative CoA binding site [chemical binding]; other site 681288005315 AMP binding site [chemical binding]; other site 681288005316 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 681288005317 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 681288005318 active site 681288005319 Zn binding site [ion binding]; other site 681288005320 catabolite control protein A; Region: ccpA; TIGR01481 681288005321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 681288005322 DNA binding site [nucleotide binding] 681288005323 domain linker motif; other site 681288005324 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 681288005325 dimerization interface [polypeptide binding]; other site 681288005326 effector binding site; other site 681288005327 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 681288005328 Chorismate mutase type II; Region: CM_2; cl00693 681288005329 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 681288005330 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 681288005331 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 681288005332 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 681288005333 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288005334 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 681288005335 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 681288005336 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 681288005337 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 681288005338 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 681288005339 putative tRNA-binding site [nucleotide binding]; other site 681288005340 hypothetical protein; Provisional; Region: PRK13668 681288005341 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 681288005342 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 681288005343 catalytic residues [active] 681288005344 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 681288005345 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 681288005346 oligomer interface [polypeptide binding]; other site 681288005347 active site 681288005348 metal binding site [ion binding]; metal-binding site 681288005349 Predicted small secreted protein [Function unknown]; Region: COG5584 681288005350 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 681288005351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288005352 S-adenosylmethionine binding site [chemical binding]; other site 681288005353 Phosphotransferase enzyme family; Region: APH; pfam01636 681288005354 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 681288005355 substrate binding site [chemical binding]; other site 681288005356 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 681288005357 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 681288005358 homodimer interface [polypeptide binding]; other site 681288005359 substrate-cofactor binding pocket; other site 681288005360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288005361 catalytic residue [active] 681288005362 dipeptidase PepV; Reviewed; Region: PRK07318 681288005363 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 681288005364 active site 681288005365 metal binding site [ion binding]; metal-binding site 681288005366 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 681288005367 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288005368 RNA binding surface [nucleotide binding]; other site 681288005369 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 681288005370 active site 681288005371 uracil binding [chemical binding]; other site 681288005372 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 681288005373 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 681288005374 HI0933-like protein; Region: HI0933_like; pfam03486 681288005375 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 681288005376 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 681288005377 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005378 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005379 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005380 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005381 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005382 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005383 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005384 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005385 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005386 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005387 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005388 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005389 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005390 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005391 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005392 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 681288005393 active site residue [active] 681288005394 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 681288005395 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 681288005396 HIGH motif; other site 681288005397 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 681288005398 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 681288005399 active site 681288005400 KMSKS motif; other site 681288005401 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 681288005402 tRNA binding surface [nucleotide binding]; other site 681288005403 SAAV_1769 681288005404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288005405 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288005406 putative substrate translocation pore; other site 681288005407 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 681288005408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288005409 S-adenosylmethionine binding site [chemical binding]; other site 681288005410 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288005411 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 681288005412 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 681288005413 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 681288005414 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 681288005415 homopentamer interface [polypeptide binding]; other site 681288005416 active site 681288005417 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 681288005418 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 681288005419 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 681288005420 dimerization interface [polypeptide binding]; other site 681288005421 active site 681288005422 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 681288005423 Lumazine binding domain; Region: Lum_binding; pfam00677 681288005424 Lumazine binding domain; Region: Lum_binding; pfam00677 681288005425 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 681288005426 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 681288005427 catalytic motif [active] 681288005428 Zn binding site [ion binding]; other site 681288005429 RibD C-terminal domain; Region: RibD_C; cl17279 681288005430 SAAV_1781 681288005431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 681288005432 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 681288005433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 681288005434 dimerization interface [polypeptide binding]; other site 681288005435 putative DNA binding site [nucleotide binding]; other site 681288005436 putative Zn2+ binding site [ion binding]; other site 681288005437 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 681288005438 arsenical pump membrane protein; Provisional; Region: PRK15445 681288005439 transmembrane helices; other site 681288005440 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 681288005441 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 681288005442 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 681288005443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 681288005444 DNA binding residues [nucleotide binding] 681288005445 CAAX protease self-immunity; Region: Abi; pfam02517 681288005446 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 681288005447 active site 681288005448 intersubunit interactions; other site 681288005449 catalytic residue [active] 681288005450 camphor resistance protein CrcB; Provisional; Region: PRK14201 681288005451 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 681288005452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 681288005453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 681288005454 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 681288005455 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288005456 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 681288005457 active site 681288005458 catalytic tetrad [active] 681288005459 S-adenosylmethionine synthetase; Validated; Region: PRK05250 681288005460 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 681288005461 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 681288005462 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 681288005463 SAAV_1800 681288005464 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 681288005465 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 681288005466 active site 681288005467 substrate-binding site [chemical binding]; other site 681288005468 metal-binding site [ion binding] 681288005469 ATP binding site [chemical binding]; other site 681288005470 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 681288005471 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 681288005472 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 681288005473 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 681288005474 nudix motif; other site 681288005475 Haemolytic domain; Region: Haemolytic; pfam01809 681288005476 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 681288005477 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 681288005478 metal binding site [ion binding]; metal-binding site 681288005479 substrate binding pocket [chemical binding]; other site 681288005480 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 681288005481 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 681288005482 acyl-activating enzyme (AAE) consensus motif; other site 681288005483 putative AMP binding site [chemical binding]; other site 681288005484 putative active site [active] 681288005485 putative CoA binding site [chemical binding]; other site 681288005486 Excalibur calcium-binding domain; Region: Excalibur; smart00894 681288005487 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 681288005488 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 681288005489 Integrase core domain; Region: rve; pfam00665 681288005490 DDE domain; Region: DDE_Tnp_IS240; pfam13610 681288005491 Integrase core domain; Region: rve_3; pfam13683 681288005492 Winged helix-turn helix; Region: HTH_29; pfam13551 681288005493 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 681288005494 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 681288005495 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 681288005496 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 681288005497 HsdM N-terminal domain; Region: HsdM_N; pfam12161 681288005498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288005499 S-adenosylmethionine binding site [chemical binding]; other site 681288005500 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 681288005501 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 681288005502 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 681288005503 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 681288005504 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 681288005505 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 681288005506 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 681288005507 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 681288005508 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 681288005509 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 681288005510 beta-channel forming cytolysin; Region: hlyII; TIGR01002 681288005511 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 681288005512 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 681288005513 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 681288005514 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 681288005515 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 681288005516 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005517 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005518 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005519 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005520 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005521 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005522 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005523 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005524 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005525 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005526 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005527 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005528 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 681288005529 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 681288005530 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 681288005531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 681288005532 ferrochelatase; Provisional; Region: PRK12435 681288005533 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 681288005534 C-terminal domain interface [polypeptide binding]; other site 681288005535 active site 681288005536 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 681288005537 active site 681288005538 N-terminal domain interface [polypeptide binding]; other site 681288005539 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 681288005540 substrate binding site [chemical binding]; other site 681288005541 active site 681288005542 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 681288005543 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 681288005544 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 681288005545 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 681288005546 Walker A/P-loop; other site 681288005547 ATP binding site [chemical binding]; other site 681288005548 Q-loop/lid; other site 681288005549 ABC transporter signature motif; other site 681288005550 Walker B; other site 681288005551 D-loop; other site 681288005552 H-loop/switch region; other site 681288005553 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 681288005554 HIT family signature motif; other site 681288005555 catalytic residue [active] 681288005556 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 681288005557 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 681288005558 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 681288005559 SurA N-terminal domain; Region: SurA_N_3; cl07813 681288005560 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 681288005561 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 681288005562 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 681288005563 generic binding surface II; other site 681288005564 generic binding surface I; other site 681288005565 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 681288005566 Zn2+ binding site [ion binding]; other site 681288005567 Mg2+ binding site [ion binding]; other site 681288005568 Uncharacterized conserved protein [Function unknown]; Region: COG4717 681288005569 P-loop containing region of AAA domain; Region: AAA_29; cl17516 681288005570 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 681288005571 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 681288005572 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 681288005573 active site 681288005574 metal binding site [ion binding]; metal-binding site 681288005575 DNA binding site [nucleotide binding] 681288005576 hypothetical protein; Provisional; Region: PRK13676 681288005577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 681288005578 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 681288005579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288005580 non-specific DNA binding site [nucleotide binding]; other site 681288005581 salt bridge; other site 681288005582 sequence-specific DNA binding site [nucleotide binding]; other site 681288005583 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 681288005584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288005585 active site 681288005586 phosphorylation site [posttranslational modification] 681288005587 intermolecular recognition site; other site 681288005588 dimerization interface [polypeptide binding]; other site 681288005589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 681288005590 DNA binding residues [nucleotide binding] 681288005591 dimerization interface [polypeptide binding]; other site 681288005592 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 681288005593 GAF domain; Region: GAF_3; pfam13492 681288005594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 681288005595 Histidine kinase; Region: HisKA_3; pfam07730 681288005596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288005597 ATP binding site [chemical binding]; other site 681288005598 Mg2+ binding site [ion binding]; other site 681288005599 G-X-G motif; other site 681288005600 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 681288005601 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 681288005602 active site 681288005603 fumarate hydratase; Reviewed; Region: fumC; PRK00485 681288005604 Class II fumarases; Region: Fumarase_classII; cd01362 681288005605 active site 681288005606 tetramer interface [polypeptide binding]; other site 681288005607 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 681288005608 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 681288005609 active site 681288005610 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 681288005611 epoxyqueuosine reductase; Region: TIGR00276 681288005612 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 681288005613 HEAT repeats; Region: HEAT_2; pfam13646 681288005614 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 681288005615 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 681288005616 Walker A/P-loop; other site 681288005617 ATP binding site [chemical binding]; other site 681288005618 Q-loop/lid; other site 681288005619 ABC transporter signature motif; other site 681288005620 Walker B; other site 681288005621 D-loop; other site 681288005622 H-loop/switch region; other site 681288005623 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 681288005624 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 681288005625 substrate binding pocket [chemical binding]; other site 681288005626 membrane-bound complex binding site; other site 681288005627 hinge residues; other site 681288005628 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 681288005629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288005630 dimer interface [polypeptide binding]; other site 681288005631 conserved gate region; other site 681288005632 putative PBP binding loops; other site 681288005633 ABC-ATPase subunit interface; other site 681288005634 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 681288005635 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 681288005636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288005637 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288005638 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 681288005639 metal binding site 2 [ion binding]; metal-binding site 681288005640 putative DNA binding helix; other site 681288005641 metal binding site 1 [ion binding]; metal-binding site 681288005642 dimer interface [polypeptide binding]; other site 681288005643 structural Zn2+ binding site [ion binding]; other site 681288005644 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 681288005645 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 681288005646 putative ligand binding site [chemical binding]; other site 681288005647 NAD binding site [chemical binding]; other site 681288005648 catalytic site [active] 681288005649 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 681288005650 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 681288005651 catalytic triad [active] 681288005652 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 681288005653 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288005654 inhibitor-cofactor binding pocket; inhibition site 681288005655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288005656 catalytic residue [active] 681288005657 Predicted membrane protein [Function unknown]; Region: COG4129 681288005658 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 681288005659 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 681288005660 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 681288005661 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 681288005662 Walker A/P-loop; other site 681288005663 ATP binding site [chemical binding]; other site 681288005664 Q-loop/lid; other site 681288005665 ABC transporter signature motif; other site 681288005666 Walker B; other site 681288005667 D-loop; other site 681288005668 H-loop/switch region; other site 681288005669 hypothetical protein; Provisional; Region: PRK13662 681288005670 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 681288005671 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 681288005672 minor groove reading motif; other site 681288005673 helix-hairpin-helix signature motif; other site 681288005674 substrate binding pocket [chemical binding]; other site 681288005675 active site 681288005676 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 681288005677 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 681288005678 DNA binding and oxoG recognition site [nucleotide binding] 681288005679 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 681288005680 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 681288005681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288005682 Walker A/P-loop; other site 681288005683 ATP binding site [chemical binding]; other site 681288005684 Q-loop/lid; other site 681288005685 ABC transporter signature motif; other site 681288005686 Walker B; other site 681288005687 H-loop/switch region; other site 681288005688 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 681288005689 recombination regulator RecX; Provisional; Region: recX; PRK14135 681288005690 glycosyltransferase; Provisional; Region: PRK13481 681288005691 Transglycosylase; Region: Transgly; pfam00912 681288005692 intracellular protease, PfpI family; Region: PfpI; TIGR01382 681288005693 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 681288005694 proposed catalytic triad [active] 681288005695 conserved cys residue [active] 681288005696 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 681288005697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288005698 FeS/SAM binding site; other site 681288005699 YfkB-like domain; Region: YfkB; pfam08756 681288005700 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 681288005701 Replication initiation factor; Region: Rep_trans; pfam02486 681288005702 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 681288005703 TcpE family; Region: TcpE; pfam12648 681288005704 AAA-like domain; Region: AAA_10; pfam12846 681288005705 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 681288005706 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 681288005707 ribonuclease E; Reviewed; Region: rne; PRK10811 681288005708 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 681288005709 Surface antigen [General function prediction only]; Region: COG3942 681288005710 CHAP domain; Region: CHAP; pfam05257 681288005711 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 681288005712 Winged helix-turn helix; Region: HTH_29; pfam13551 681288005713 Homeodomain-like domain; Region: HTH_32; pfam13565 681288005714 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 681288005715 Integrase core domain; Region: rve; pfam00665 681288005716 Class I aldolases; Region: Aldolase_Class_I; cl17187 681288005717 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 681288005718 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 681288005719 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 681288005720 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 681288005721 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 681288005722 Low molecular weight phosphatase family; Region: LMWPc; cd00115 681288005723 active site 681288005724 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 681288005725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 681288005726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288005727 active site 681288005728 phosphorylation site [posttranslational modification] 681288005729 intermolecular recognition site; other site 681288005730 dimerization interface [polypeptide binding]; other site 681288005731 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 681288005732 DNA binding residues [nucleotide binding] 681288005733 dimerization interface [polypeptide binding]; other site 681288005734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 681288005735 Histidine kinase; Region: HisKA_3; pfam07730 681288005736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288005737 ATP binding site [chemical binding]; other site 681288005738 Mg2+ binding site [ion binding]; other site 681288005739 G-X-G motif; other site 681288005740 Predicted membrane protein [Function unknown]; Region: COG4758 681288005741 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 681288005742 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 681288005743 active site 681288005744 Predicted membrane protein [Function unknown]; Region: COG4129 681288005745 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 681288005746 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 681288005747 catalytic triad [active] 681288005748 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 681288005749 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288005750 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 681288005751 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 681288005752 Ferritin-like domain; Region: Ferritin; pfam00210 681288005753 ferroxidase diiron center [ion binding]; other site 681288005754 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 681288005755 active site 681288005756 catalytic site [active] 681288005757 substrate binding site [chemical binding]; other site 681288005758 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 681288005759 active site 681288005760 DNA polymerase IV; Validated; Region: PRK02406 681288005761 DNA binding site [nucleotide binding] 681288005762 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 681288005763 TRAM domain; Region: TRAM; cl01282 681288005764 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 681288005765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288005766 S-adenosylmethionine binding site [chemical binding]; other site 681288005767 putative lipid kinase; Reviewed; Region: PRK13337 681288005768 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 681288005769 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 681288005770 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 681288005771 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 681288005772 GatB domain; Region: GatB_Yqey; pfam02637 681288005773 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 681288005774 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 681288005775 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 681288005776 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 681288005777 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 681288005778 Na binding site [ion binding]; other site 681288005779 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 681288005780 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 681288005781 putative dimer interface [polypeptide binding]; other site 681288005782 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 681288005783 putative dimer interface [polypeptide binding]; other site 681288005784 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 681288005785 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 681288005786 nucleotide binding pocket [chemical binding]; other site 681288005787 K-X-D-G motif; other site 681288005788 catalytic site [active] 681288005789 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 681288005790 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 681288005791 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 681288005792 Dimer interface [polypeptide binding]; other site 681288005793 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 681288005794 Part of AAA domain; Region: AAA_19; pfam13245 681288005795 Family description; Region: UvrD_C_2; pfam13538 681288005796 PcrB family; Region: PcrB; pfam01884 681288005797 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 681288005798 substrate binding site [chemical binding]; other site 681288005799 putative active site [active] 681288005800 dimer interface [polypeptide binding]; other site 681288005801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 681288005802 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 681288005803 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 681288005804 tetramer interface [polypeptide binding]; other site 681288005805 active site 681288005806 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 681288005807 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 681288005808 Staphostatin A; Region: Staphostatin_A; pfam09022 681288005809 NETI protein; Region: NETI; pfam14044 681288005810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 681288005811 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 681288005812 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 681288005813 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 681288005814 homodimer interface [polypeptide binding]; other site 681288005815 NAD binding pocket [chemical binding]; other site 681288005816 ATP binding pocket [chemical binding]; other site 681288005817 Mg binding site [ion binding]; other site 681288005818 active-site loop [active] 681288005819 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 681288005820 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 681288005821 active site 681288005822 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 681288005823 active site 681288005824 dimer interface [polypeptide binding]; other site 681288005825 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 681288005826 Prephenate dehydratase; Region: PDT; pfam00800 681288005827 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 681288005828 putative L-Phe binding site [chemical binding]; other site 681288005829 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 681288005830 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 681288005831 transmembrane helices; other site 681288005832 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 681288005833 Isochorismatase family; Region: Isochorismatase; pfam00857 681288005834 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 681288005835 catalytic triad [active] 681288005836 conserved cis-peptide bond; other site 681288005837 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 681288005838 DHH family; Region: DHH; pfam01368 681288005839 DHHA2 domain; Region: DHHA2; pfam02833 681288005840 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 681288005841 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 681288005842 NAD(P) binding site [chemical binding]; other site 681288005843 catalytic residues [active] 681288005844 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 681288005845 YolD-like protein; Region: YolD; pfam08863 681288005846 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 681288005847 active site 681288005848 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 681288005849 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 681288005850 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 681288005851 Bacterial PH domain; Region: DUF304; cl01348 681288005852 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 681288005853 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 681288005854 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 681288005855 Walker A/P-loop; other site 681288005856 ATP binding site [chemical binding]; other site 681288005857 Q-loop/lid; other site 681288005858 ABC transporter signature motif; other site 681288005859 Walker B; other site 681288005860 D-loop; other site 681288005861 H-loop/switch region; other site 681288005862 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 681288005863 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 681288005864 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 681288005865 Walker A/P-loop; other site 681288005866 ATP binding site [chemical binding]; other site 681288005867 Q-loop/lid; other site 681288005868 ABC transporter signature motif; other site 681288005869 Walker B; other site 681288005870 D-loop; other site 681288005871 H-loop/switch region; other site 681288005872 Predicted transcriptional regulators [Transcription]; Region: COG1725 681288005873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288005874 DNA-binding site [nucleotide binding]; DNA binding site 681288005875 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 681288005876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288005877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288005878 homodimer interface [polypeptide binding]; other site 681288005879 catalytic residue [active] 681288005880 MAP domain; Region: MAP; pfam03642 681288005881 MAP domain; Region: MAP; pfam03642 681288005882 MAP domain; Region: MAP; pfam03642 681288005883 MAP domain; Region: MAP; pfam03642 681288005884 MAP domain; Region: MAP; pfam03642 681288005885 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 681288005886 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 681288005887 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 681288005888 CAAX protease self-immunity; Region: Abi; pfam02517 681288005889 CHAP domain; Region: CHAP; pfam05257 681288005890 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 681288005891 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 681288005892 active site 681288005893 metal binding site [ion binding]; metal-binding site 681288005894 Bacterial SH3 domain; Region: SH3_5; pfam08460 681288005895 holin, SPP1 family; Region: holin_SPP1; TIGR01592 681288005896 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 681288005897 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 681288005898 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 681288005899 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 681288005900 hypothetical protein; Provisional; Region: PRK05926 681288005901 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 681288005902 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 681288005903 Phage tail protein; Region: Sipho_tail; pfam05709 681288005904 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 681288005905 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 681288005906 linker region; other site 681288005907 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 681288005908 hypothetical protein; Provisional; Region: PHA02937 681288005909 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 681288005910 Peptidase family M23; Region: Peptidase_M23; pfam01551 681288005911 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 681288005912 N-acetyl-D-glucosamine binding site [chemical binding]; other site 681288005913 catalytic residue [active] 681288005914 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 681288005915 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 681288005916 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 681288005917 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 681288005918 oligomerization interface [polypeptide binding]; other site 681288005919 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 681288005920 Phage capsid family; Region: Phage_capsid; pfam05065 681288005921 Clp protease; Region: CLP_protease; pfam00574 681288005922 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 681288005923 oligomer interface [polypeptide binding]; other site 681288005924 active site residues [active] 681288005925 Phage-related protein [Function unknown]; Region: COG4695; cl01923 681288005926 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 681288005927 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 681288005928 Phage terminase, small subunit; Region: Terminase_4; pfam05119 681288005929 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 681288005930 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 681288005931 active site 681288005932 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 681288005933 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 681288005934 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 681288005935 dUTPase; Region: dUTPase_2; pfam08761 681288005936 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 681288005937 active site 681288005938 homodimer interface [polypeptide binding]; other site 681288005939 metal binding site [ion binding]; metal-binding site 681288005940 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 681288005941 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 681288005942 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 681288005943 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 681288005944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288005945 sequence-specific DNA binding site [nucleotide binding]; other site 681288005946 salt bridge; other site 681288005947 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 681288005948 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 681288005949 active site 681288005950 metal-binding site 681288005951 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 681288005952 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 681288005953 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 681288005954 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 681288005955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 681288005956 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 681288005957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288005958 non-specific DNA binding site [nucleotide binding]; other site 681288005959 salt bridge; other site 681288005960 sequence-specific DNA binding site [nucleotide binding]; other site 681288005961 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 681288005962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288005963 non-specific DNA binding site [nucleotide binding]; other site 681288005964 salt bridge; other site 681288005965 sequence-specific DNA binding site [nucleotide binding]; other site 681288005966 Domain of unknown function (DUF955); Region: DUF955; pfam06114 681288005967 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 681288005968 PemK-like protein; Region: PemK; pfam02452 681288005969 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 681288005970 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 681288005971 Int/Topo IB signature motif; other site 681288005972 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 681288005973 putative catalytic site [active] 681288005974 phosphate binding site [ion binding]; other site 681288005975 metal binding site A [ion binding]; metal-binding site 681288005976 metal binding site C [ion binding]; metal-binding site 681288005977 metal binding site B [ion binding]; metal-binding site 681288005978 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 681288005979 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 681288005980 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 681288005981 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 681288005982 metal binding site [ion binding]; metal-binding site 681288005983 dimer interface [polypeptide binding]; other site 681288005984 Cation transport protein; Region: TrkH; cl17365 681288005985 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 681288005986 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 681288005987 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 681288005988 ring oligomerisation interface [polypeptide binding]; other site 681288005989 ATP/Mg binding site [chemical binding]; other site 681288005990 stacking interactions; other site 681288005991 hinge regions; other site 681288005992 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 681288005993 oligomerisation interface [polypeptide binding]; other site 681288005994 mobile loop; other site 681288005995 roof hairpin; other site 681288005996 CAAX protease self-immunity; Region: Abi; pfam02517 681288005997 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 681288005998 dimer interface [polypeptide binding]; other site 681288005999 FMN binding site [chemical binding]; other site 681288006000 Predicted amidohydrolase [General function prediction only]; Region: COG0388 681288006001 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 681288006002 putative active site [active] 681288006003 catalytic triad [active] 681288006004 putative dimer interface [polypeptide binding]; other site 681288006005 delta-hemolysin; Provisional; Region: PRK14752 681288006006 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512 681288006007 Staphylococcal AgrD protein; Region: AgrD; pfam05931 681288006008 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 681288006009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288006010 Mg2+ binding site [ion binding]; other site 681288006011 G-X-G motif; other site 681288006012 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 681288006013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288006014 active site 681288006015 phosphorylation site [posttranslational modification] 681288006016 intermolecular recognition site; other site 681288006017 dimerization interface [polypeptide binding]; other site 681288006018 LytTr DNA-binding domain; Region: LytTR; pfam04397 681288006019 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 681288006020 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 681288006021 putative substrate binding site [chemical binding]; other site 681288006022 putative ATP binding site [chemical binding]; other site 681288006023 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 681288006024 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 681288006025 substrate binding [chemical binding]; other site 681288006026 active site 681288006027 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 681288006028 Transcriptional regulators [Transcription]; Region: PurR; COG1609 681288006029 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 681288006030 DNA binding site [nucleotide binding] 681288006031 domain linker motif; other site 681288006032 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 681288006033 dimerization interface [polypeptide binding]; other site 681288006034 ligand binding site [chemical binding]; other site 681288006035 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 681288006036 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 681288006037 CPxP motif; other site 681288006038 Predicted transporter component [General function prediction only]; Region: COG2391 681288006039 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 681288006040 Sulphur transport; Region: Sulf_transp; pfam04143 681288006041 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 681288006042 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 681288006043 CoA binding domain; Region: CoA_binding; pfam02629 681288006044 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 681288006045 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 681288006046 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 681288006047 ABC transporter; Region: ABC_tran_2; pfam12848 681288006048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 681288006049 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 681288006050 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 681288006051 Walker A/P-loop; other site 681288006052 ATP binding site [chemical binding]; other site 681288006053 Q-loop/lid; other site 681288006054 ABC transporter signature motif; other site 681288006055 Walker B; other site 681288006056 D-loop; other site 681288006057 H-loop/switch region; other site 681288006058 UGMP family protein; Validated; Region: PRK09604 681288006059 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 681288006060 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 681288006061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288006062 Coenzyme A binding pocket [chemical binding]; other site 681288006063 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 681288006064 Glycoprotease family; Region: Peptidase_M22; pfam00814 681288006065 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 681288006066 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 681288006067 6-phosphogluconate dehydratase; Region: edd; TIGR01196 681288006068 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 681288006069 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 681288006070 PYR/PP interface [polypeptide binding]; other site 681288006071 dimer interface [polypeptide binding]; other site 681288006072 TPP binding site [chemical binding]; other site 681288006073 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 681288006074 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 681288006075 TPP-binding site [chemical binding]; other site 681288006076 dimer interface [polypeptide binding]; other site 681288006077 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 681288006078 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 681288006079 ketol-acid reductoisomerase; Provisional; Region: PRK05479 681288006080 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 681288006081 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 681288006082 2-isopropylmalate synthase; Validated; Region: PRK00915 681288006083 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 681288006084 active site 681288006085 catalytic residues [active] 681288006086 metal binding site [ion binding]; metal-binding site 681288006087 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 681288006088 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 681288006089 tartrate dehydrogenase; Region: TTC; TIGR02089 681288006090 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 681288006091 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 681288006092 substrate binding site [chemical binding]; other site 681288006093 ligand binding site [chemical binding]; other site 681288006094 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 681288006095 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 681288006096 substrate binding site [chemical binding]; other site 681288006097 threonine dehydratase; Validated; Region: PRK08639 681288006098 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 681288006099 tetramer interface [polypeptide binding]; other site 681288006100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288006101 catalytic residue [active] 681288006102 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 681288006103 putative Ile/Val binding site [chemical binding]; other site 681288006104 hypothetical protein; Provisional; Region: PRK04351 681288006105 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 681288006106 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 681288006107 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 681288006108 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 681288006109 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 681288006110 RNA binding site [nucleotide binding]; other site 681288006111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288006112 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288006113 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 681288006114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 681288006115 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 681288006116 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 681288006117 DNA binding residues [nucleotide binding] 681288006118 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 681288006119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288006120 ATP binding site [chemical binding]; other site 681288006121 Mg2+ binding site [ion binding]; other site 681288006122 G-X-G motif; other site 681288006123 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 681288006124 anti sigma factor interaction site; other site 681288006125 regulatory phosphorylation site [posttranslational modification]; other site 681288006126 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 681288006127 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 681288006128 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 681288006129 PemK-like protein; Region: PemK; pfam02452 681288006130 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 681288006131 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 681288006132 active site 681288006133 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288006134 dimer interface [polypeptide binding]; other site 681288006135 substrate binding site [chemical binding]; other site 681288006136 catalytic residues [active] 681288006137 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 681288006138 Uncharacterized conserved protein [Function unknown]; Region: COG3402 681288006139 Predicted membrane protein [Function unknown]; Region: COG3428 681288006140 Bacterial PH domain; Region: DUF304; pfam03703 681288006141 Bacterial PH domain; Region: DUF304; pfam03703 681288006142 Bacterial PH domain; Region: DUF304; cl01348 681288006143 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 681288006144 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 681288006145 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 681288006146 Soluble P-type ATPase [General function prediction only]; Region: COG4087 681288006147 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 681288006148 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 681288006149 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 681288006150 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 681288006151 Ligand Binding Site [chemical binding]; other site 681288006152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288006153 dimer interface [polypeptide binding]; other site 681288006154 phosphorylation site [posttranslational modification] 681288006155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288006156 ATP binding site [chemical binding]; other site 681288006157 Mg2+ binding site [ion binding]; other site 681288006158 G-X-G motif; other site 681288006159 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288006160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288006161 active site 681288006162 phosphorylation site [posttranslational modification] 681288006163 intermolecular recognition site; other site 681288006164 dimerization interface [polypeptide binding]; other site 681288006165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288006166 DNA binding site [nucleotide binding] 681288006167 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 681288006168 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 681288006169 ATP binding site [chemical binding]; other site 681288006170 Mg++ binding site [ion binding]; other site 681288006171 motif III; other site 681288006172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288006173 nucleotide binding region [chemical binding]; other site 681288006174 ATP-binding site [chemical binding]; other site 681288006175 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 681288006176 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 681288006177 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288006178 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 681288006179 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 681288006180 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 681288006181 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 681288006182 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 681288006183 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 681288006184 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 681288006185 putative homodimer interface [polypeptide binding]; other site 681288006186 putative homotetramer interface [polypeptide binding]; other site 681288006187 allosteric switch controlling residues; other site 681288006188 putative metal binding site [ion binding]; other site 681288006189 putative homodimer-homodimer interface [polypeptide binding]; other site 681288006190 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 681288006191 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 681288006192 putative active site [active] 681288006193 catalytic site [active] 681288006194 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 681288006195 putative active site [active] 681288006196 catalytic site [active] 681288006197 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 681288006198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 681288006199 Zn2+ binding site [ion binding]; other site 681288006200 Mg2+ binding site [ion binding]; other site 681288006201 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 681288006202 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 681288006203 thiamine phosphate binding site [chemical binding]; other site 681288006204 active site 681288006205 pyrophosphate binding site [ion binding]; other site 681288006206 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 681288006207 substrate binding site [chemical binding]; other site 681288006208 multimerization interface [polypeptide binding]; other site 681288006209 ATP binding site [chemical binding]; other site 681288006210 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 681288006211 dimer interface [polypeptide binding]; other site 681288006212 substrate binding site [chemical binding]; other site 681288006213 ATP binding site [chemical binding]; other site 681288006214 thiaminase II; Region: salvage_TenA; TIGR04306 681288006215 SAAV_2149 681288006216 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 681288006217 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 681288006218 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 681288006219 dimer interface [polypeptide binding]; other site 681288006220 ssDNA binding site [nucleotide binding]; other site 681288006221 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288006222 YwpF-like protein; Region: YwpF; pfam14183 681288006223 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 681288006224 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 681288006225 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 681288006226 hinge; other site 681288006227 active site 681288006228 Predicted membrane protein [Function unknown]; Region: COG4836 681288006229 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 681288006230 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 681288006231 gamma subunit interface [polypeptide binding]; other site 681288006232 epsilon subunit interface [polypeptide binding]; other site 681288006233 LBP interface [polypeptide binding]; other site 681288006234 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 681288006235 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 681288006236 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 681288006237 alpha subunit interaction interface [polypeptide binding]; other site 681288006238 Walker A motif; other site 681288006239 ATP binding site [chemical binding]; other site 681288006240 Walker B motif; other site 681288006241 inhibitor binding site; inhibition site 681288006242 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 681288006243 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 681288006244 core domain interface [polypeptide binding]; other site 681288006245 delta subunit interface [polypeptide binding]; other site 681288006246 epsilon subunit interface [polypeptide binding]; other site 681288006247 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 681288006248 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 681288006249 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 681288006250 beta subunit interaction interface [polypeptide binding]; other site 681288006251 Walker A motif; other site 681288006252 ATP binding site [chemical binding]; other site 681288006253 Walker B motif; other site 681288006254 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 681288006255 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 681288006256 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 681288006257 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 681288006258 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 681288006259 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 681288006260 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 681288006261 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 681288006262 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 681288006263 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 681288006264 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 681288006265 active site 681288006266 homodimer interface [polypeptide binding]; other site 681288006267 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288006268 active site 681288006269 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 681288006270 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 681288006271 dimer interface [polypeptide binding]; other site 681288006272 active site 681288006273 glycine-pyridoxal phosphate binding site [chemical binding]; other site 681288006274 folate binding site [chemical binding]; other site 681288006275 hypothetical protein; Provisional; Region: PRK13690 681288006276 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 681288006277 Low molecular weight phosphatase family; Region: LMWPc; cd00115 681288006278 active site 681288006279 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 681288006280 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 681288006281 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 681288006282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288006283 S-adenosylmethionine binding site [chemical binding]; other site 681288006284 peptide chain release factor 1; Validated; Region: prfA; PRK00591 681288006285 This domain is found in peptide chain release factors; Region: PCRF; smart00937 681288006286 RF-1 domain; Region: RF-1; pfam00472 681288006287 thymidine kinase; Provisional; Region: PRK04296 681288006288 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 681288006289 transcription termination factor Rho; Provisional; Region: rho; PRK09376 681288006290 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 681288006291 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 681288006292 RNA binding site [nucleotide binding]; other site 681288006293 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 681288006294 multimer interface [polypeptide binding]; other site 681288006295 Walker A motif; other site 681288006296 ATP binding site [chemical binding]; other site 681288006297 Walker B motif; other site 681288006298 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 681288006299 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 681288006300 NAD binding site [chemical binding]; other site 681288006301 catalytic residues [active] 681288006302 Predicted transcriptional regulators [Transcription]; Region: COG1733 681288006303 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 681288006304 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 681288006305 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 681288006306 hinge; other site 681288006307 active site 681288006308 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 681288006309 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 681288006310 intersubunit interface [polypeptide binding]; other site 681288006311 active site 681288006312 zinc binding site [ion binding]; other site 681288006313 Na+ binding site [ion binding]; other site 681288006314 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 681288006315 CTP synthetase; Validated; Region: pyrG; PRK05380 681288006316 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 681288006317 Catalytic site [active] 681288006318 active site 681288006319 UTP binding site [chemical binding]; other site 681288006320 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 681288006321 active site 681288006322 putative oxyanion hole; other site 681288006323 catalytic triad [active] 681288006324 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 681288006325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288006326 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 681288006327 Coenzyme A binding pocket [chemical binding]; other site 681288006328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 681288006329 Coenzyme A binding pocket [chemical binding]; other site 681288006330 pantothenate kinase; Provisional; Region: PRK13317 681288006331 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 681288006332 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 681288006333 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 681288006334 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 681288006335 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 681288006336 metal binding site [ion binding]; metal-binding site 681288006337 S-ribosylhomocysteinase; Provisional; Region: PRK02260 681288006338 Predicted membrane protein [Function unknown]; Region: COG4270 681288006339 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 681288006340 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 681288006341 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 681288006342 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 681288006343 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 681288006344 intersubunit interface [polypeptide binding]; other site 681288006345 active site 681288006346 catalytic residue [active] 681288006347 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 681288006348 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 681288006349 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 681288006350 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 681288006351 dimerization interface [polypeptide binding]; other site 681288006352 DPS ferroxidase diiron center [ion binding]; other site 681288006353 ion pore; other site 681288006354 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 681288006355 EVE domain; Region: EVE; cl00728 681288006356 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 681288006357 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 681288006358 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 681288006359 NADH(P)-binding; Region: NAD_binding_10; pfam13460 681288006360 NAD(P) binding site [chemical binding]; other site 681288006361 putative active site [active] 681288006362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 681288006363 dimerization interface [polypeptide binding]; other site 681288006364 putative DNA binding site [nucleotide binding]; other site 681288006365 putative Zn2+ binding site [ion binding]; other site 681288006366 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 681288006367 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 681288006368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 681288006369 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 681288006370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288006371 active site 681288006372 motif I; other site 681288006373 motif II; other site 681288006374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288006375 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 681288006376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288006377 Walker A/P-loop; other site 681288006378 ATP binding site [chemical binding]; other site 681288006379 Q-loop/lid; other site 681288006380 ABC transporter signature motif; other site 681288006381 Walker B; other site 681288006382 D-loop; other site 681288006383 H-loop/switch region; other site 681288006384 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 681288006385 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 681288006386 glutaminase active site [active] 681288006387 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 681288006388 dimer interface [polypeptide binding]; other site 681288006389 active site 681288006390 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 681288006391 dimer interface [polypeptide binding]; other site 681288006392 active site 681288006393 SAAV_2209 681288006394 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 681288006395 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 681288006396 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 681288006397 active site 681288006398 P-loop; other site 681288006399 phosphorylation site [posttranslational modification] 681288006400 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 681288006401 HTH domain; Region: HTH_11; pfam08279 681288006402 Mga helix-turn-helix domain; Region: Mga; pfam05043 681288006403 PRD domain; Region: PRD; pfam00874 681288006404 PRD domain; Region: PRD; pfam00874 681288006405 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 681288006406 active site 681288006407 P-loop; other site 681288006408 phosphorylation site [posttranslational modification] 681288006409 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 681288006410 active site 681288006411 phosphorylation site [posttranslational modification] 681288006412 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288006413 active site 681288006414 phosphorylation site [posttranslational modification] 681288006415 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 681288006416 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 681288006417 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 681288006418 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 681288006419 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 681288006420 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006421 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006422 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006423 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006424 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006425 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006426 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006427 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 681288006428 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 681288006429 active site 681288006430 substrate binding site [chemical binding]; other site 681288006431 metal binding site [ion binding]; metal-binding site 681288006432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 681288006433 YbbR-like protein; Region: YbbR; pfam07949 681288006434 TIGR00159 family protein; Region: TIGR00159 681288006435 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 681288006436 Arginase family; Region: Arginase; cd09989 681288006437 active site 681288006438 Mn binding site [ion binding]; other site 681288006439 oligomer interface [polypeptide binding]; other site 681288006440 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 681288006441 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 681288006442 Walker A motif; other site 681288006443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288006445 putative substrate translocation pore; other site 681288006446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288006448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006449 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 681288006450 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 681288006451 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 681288006452 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 681288006453 substrate binding site; other site 681288006454 dimerization interface; other site 681288006455 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 681288006456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 681288006457 Nucleoside recognition; Region: Gate; pfam07670 681288006458 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 681288006459 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288006460 ABC-ATPase subunit interface; other site 681288006461 dimer interface [polypeptide binding]; other site 681288006462 putative PBP binding regions; other site 681288006463 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 681288006464 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288006465 ABC-ATPase subunit interface; other site 681288006466 dimer interface [polypeptide binding]; other site 681288006467 putative PBP binding regions; other site 681288006468 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 681288006469 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 681288006470 siderophore binding site; other site 681288006471 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 681288006472 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 681288006473 dimer interface [polypeptide binding]; other site 681288006474 active site 681288006475 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288006476 substrate binding site [chemical binding]; other site 681288006477 catalytic residue [active] 681288006478 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 681288006479 IucA / IucC family; Region: IucA_IucC; pfam04183 681288006480 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 681288006481 H+ Antiporter protein; Region: 2A0121; TIGR00900 681288006482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006483 putative substrate translocation pore; other site 681288006484 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 681288006485 IucA / IucC family; Region: IucA_IucC; pfam04183 681288006486 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 681288006487 Asp23 family; Region: Asp23; pfam03780 681288006488 Small integral membrane protein [Function unknown]; Region: COG5547 681288006489 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 681288006490 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 681288006491 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 681288006492 putative NAD(P) binding site [chemical binding]; other site 681288006493 dimer interface [polypeptide binding]; other site 681288006494 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 681288006495 Prostaglandin dehydrogenases; Region: PGDH; cd05288 681288006496 NAD(P) binding site [chemical binding]; other site 681288006497 substrate binding site [chemical binding]; other site 681288006498 dimer interface [polypeptide binding]; other site 681288006499 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 681288006500 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 681288006501 beta-galactosidase; Region: BGL; TIGR03356 681288006502 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 681288006503 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 681288006504 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 681288006505 active site 681288006506 P-loop; other site 681288006507 phosphorylation site [posttranslational modification] 681288006508 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 681288006509 methionine cluster; other site 681288006510 active site 681288006511 phosphorylation site [posttranslational modification] 681288006512 metal binding site [ion binding]; metal-binding site 681288006513 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 681288006514 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 681288006515 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 681288006516 putative substrate binding site [chemical binding]; other site 681288006517 putative ATP binding site [chemical binding]; other site 681288006518 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 681288006519 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 681288006520 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 681288006521 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 681288006522 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 681288006523 NAD-dependent deacetylase; Provisional; Region: PRK00481 681288006524 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 681288006525 NAD+ binding site [chemical binding]; other site 681288006526 substrate binding site [chemical binding]; other site 681288006527 putative Zn binding site [ion binding]; other site 681288006528 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288006529 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 681288006530 active site 681288006531 catalytic tetrad [active] 681288006532 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 681288006533 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 681288006534 DNA binding residues [nucleotide binding] 681288006535 putative dimer interface [polypeptide binding]; other site 681288006536 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 681288006537 substrate binding site [chemical binding]; other site 681288006538 catalytic residues [active] 681288006539 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 681288006540 Peptidase family M23; Region: Peptidase_M23; pfam01551 681288006541 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 681288006542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 681288006543 active site 681288006544 motif I; other site 681288006545 motif II; other site 681288006546 MAP domain; Region: MAP; pfam03642 681288006547 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 681288006548 acetolactate synthase; Reviewed; Region: PRK08617 681288006549 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 681288006550 PYR/PP interface [polypeptide binding]; other site 681288006551 dimer interface [polypeptide binding]; other site 681288006552 TPP binding site [chemical binding]; other site 681288006553 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 681288006554 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 681288006555 TPP-binding site [chemical binding]; other site 681288006556 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 681288006557 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 681288006558 putative active site [active] 681288006559 putative NTP binding site [chemical binding]; other site 681288006560 putative nucleic acid binding site [nucleotide binding]; other site 681288006561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 681288006562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 681288006563 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 681288006564 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 681288006565 23S rRNA interface [nucleotide binding]; other site 681288006566 L3 interface [polypeptide binding]; other site 681288006567 SAAV_2280 681288006568 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 681288006569 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 681288006570 dimerization interface 3.5A [polypeptide binding]; other site 681288006571 active site 681288006572 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 681288006573 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 681288006574 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 681288006575 Walker A/P-loop; other site 681288006576 ATP binding site [chemical binding]; other site 681288006577 Q-loop/lid; other site 681288006578 ABC transporter signature motif; other site 681288006579 Walker B; other site 681288006580 D-loop; other site 681288006581 H-loop/switch region; other site 681288006582 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 681288006583 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 681288006584 Walker A/P-loop; other site 681288006585 ATP binding site [chemical binding]; other site 681288006586 Q-loop/lid; other site 681288006587 ABC transporter signature motif; other site 681288006588 Walker B; other site 681288006589 D-loop; other site 681288006590 H-loop/switch region; other site 681288006591 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 681288006592 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 681288006593 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 681288006594 alphaNTD homodimer interface [polypeptide binding]; other site 681288006595 alphaNTD - beta interaction site [polypeptide binding]; other site 681288006596 alphaNTD - beta' interaction site [polypeptide binding]; other site 681288006597 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 681288006598 30S ribosomal protein S11; Validated; Region: PRK05309 681288006599 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 681288006600 30S ribosomal protein S13; Region: bact_S13; TIGR03631 681288006601 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 681288006602 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 681288006603 rRNA binding site [nucleotide binding]; other site 681288006604 predicted 30S ribosome binding site; other site 681288006605 adenylate kinase; Reviewed; Region: adk; PRK00279 681288006606 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 681288006607 AMP-binding site [chemical binding]; other site 681288006608 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 681288006609 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 681288006610 SecY translocase; Region: SecY; pfam00344 681288006611 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 681288006612 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 681288006613 23S rRNA binding site [nucleotide binding]; other site 681288006614 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 681288006615 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 681288006616 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 681288006617 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 681288006618 5S rRNA interface [nucleotide binding]; other site 681288006619 L27 interface [polypeptide binding]; other site 681288006620 23S rRNA interface [nucleotide binding]; other site 681288006621 L5 interface [polypeptide binding]; other site 681288006622 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 681288006623 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 681288006624 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 681288006625 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 681288006626 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 681288006627 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 681288006628 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 681288006629 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 681288006630 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 681288006631 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 681288006632 RNA binding site [nucleotide binding]; other site 681288006633 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 681288006634 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 681288006635 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 681288006636 23S rRNA interface [nucleotide binding]; other site 681288006637 putative translocon interaction site; other site 681288006638 signal recognition particle (SRP54) interaction site; other site 681288006639 L23 interface [polypeptide binding]; other site 681288006640 trigger factor interaction site; other site 681288006641 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 681288006642 23S rRNA interface [nucleotide binding]; other site 681288006643 5S rRNA interface [nucleotide binding]; other site 681288006644 putative antibiotic binding site [chemical binding]; other site 681288006645 L25 interface [polypeptide binding]; other site 681288006646 L27 interface [polypeptide binding]; other site 681288006647 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 681288006648 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 681288006649 G-X-X-G motif; other site 681288006650 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 681288006651 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 681288006652 putative translocon binding site; other site 681288006653 protein-rRNA interface [nucleotide binding]; other site 681288006654 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 681288006655 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 681288006656 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 681288006657 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 681288006658 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 681288006659 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 681288006660 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 681288006661 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 681288006662 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 681288006663 DNA topoisomerase III; Provisional; Region: PRK07726 681288006664 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 681288006665 active site 681288006666 putative interdomain interaction site [polypeptide binding]; other site 681288006667 putative metal-binding site [ion binding]; other site 681288006668 putative nucleotide binding site [chemical binding]; other site 681288006669 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 681288006670 domain I; other site 681288006671 DNA binding groove [nucleotide binding] 681288006672 phosphate binding site [ion binding]; other site 681288006673 domain II; other site 681288006674 domain III; other site 681288006675 nucleotide binding site [chemical binding]; other site 681288006676 catalytic site [active] 681288006677 domain IV; other site 681288006678 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 681288006679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288006680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 681288006681 Coenzyme A binding pocket [chemical binding]; other site 681288006682 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 681288006683 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 681288006684 Predicted permeases [General function prediction only]; Region: COG0679 681288006685 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 681288006686 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 681288006687 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 681288006688 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 681288006689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288006691 putative substrate translocation pore; other site 681288006692 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288006693 Transcriptional regulators [Transcription]; Region: MarR; COG1846 681288006694 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 681288006695 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288006696 FeS/SAM binding site; other site 681288006697 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 681288006698 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 681288006699 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 681288006700 GTP binding site; other site 681288006701 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 681288006702 MoaE interaction surface [polypeptide binding]; other site 681288006703 MoeB interaction surface [polypeptide binding]; other site 681288006704 thiocarboxylated glycine; other site 681288006705 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 681288006706 MoaE homodimer interface [polypeptide binding]; other site 681288006707 MoaD interaction [polypeptide binding]; other site 681288006708 active site residues [active] 681288006709 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 681288006710 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 681288006711 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 681288006712 dimer interface [polypeptide binding]; other site 681288006713 putative functional site; other site 681288006714 putative MPT binding site; other site 681288006715 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 681288006716 trimer interface [polypeptide binding]; other site 681288006717 dimer interface [polypeptide binding]; other site 681288006718 putative active site [active] 681288006719 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 681288006720 MPT binding site; other site 681288006721 trimer interface [polypeptide binding]; other site 681288006722 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 681288006723 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 681288006724 ATP binding site [chemical binding]; other site 681288006725 substrate interface [chemical binding]; other site 681288006726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288006727 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 681288006728 Walker A/P-loop; other site 681288006729 ATP binding site [chemical binding]; other site 681288006730 Q-loop/lid; other site 681288006731 ABC transporter signature motif; other site 681288006732 Walker B; other site 681288006733 D-loop; other site 681288006734 H-loop/switch region; other site 681288006735 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 681288006736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288006737 dimer interface [polypeptide binding]; other site 681288006738 conserved gate region; other site 681288006739 putative PBP binding loops; other site 681288006740 ABC-ATPase subunit interface; other site 681288006741 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 681288006742 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 681288006743 substrate binding pocket [chemical binding]; other site 681288006744 membrane-bound complex binding site; other site 681288006745 hinge residues; other site 681288006746 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 681288006747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288006748 Coenzyme A binding pocket [chemical binding]; other site 681288006749 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 681288006750 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 681288006751 active site 681288006752 dimerization interface [polypeptide binding]; other site 681288006753 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 681288006754 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 681288006755 intersubunit interface [polypeptide binding]; other site 681288006756 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 681288006757 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 681288006758 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 681288006759 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 681288006760 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 681288006761 alpha-gamma subunit interface [polypeptide binding]; other site 681288006762 beta-gamma subunit interface [polypeptide binding]; other site 681288006763 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 681288006764 gamma-beta subunit interface [polypeptide binding]; other site 681288006765 alpha-beta subunit interface [polypeptide binding]; other site 681288006766 urease subunit alpha; Reviewed; Region: ureC; PRK13207 681288006767 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 681288006768 subunit interactions [polypeptide binding]; other site 681288006769 active site 681288006770 flap region; other site 681288006771 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 681288006772 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 681288006773 dimer interface [polypeptide binding]; other site 681288006774 catalytic residues [active] 681288006775 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 681288006776 UreF; Region: UreF; pfam01730 681288006777 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 681288006778 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 681288006779 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288006780 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288006781 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288006782 Transcriptional regulators [Transcription]; Region: MarR; COG1846 681288006783 Helix-turn-helix domain; Region: HTH_18; pfam12833 681288006784 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288006785 Surface antigen [General function prediction only]; Region: COG3942 681288006786 CHAP domain; Region: CHAP; pfam05257 681288006787 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 681288006788 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 681288006789 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 681288006790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 681288006791 Surface antigen [General function prediction only]; Region: COG3942 681288006792 CHAP domain; Region: CHAP; pfam05257 681288006793 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 681288006794 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 681288006795 putative ligand binding site [chemical binding]; other site 681288006796 putative NAD binding site [chemical binding]; other site 681288006797 catalytic site [active] 681288006798 hypothetical protein; Provisional; Region: PRK06753 681288006799 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 681288006800 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 681288006801 Lysozyme subfamily 2; Region: LYZ2; smart00047 681288006802 Uncharacterized conserved protein [Function unknown]; Region: COG2427 681288006803 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 681288006804 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 681288006805 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 681288006806 4Fe-4S binding domain; Region: Fer4; pfam00037 681288006807 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 681288006808 [4Fe-4S] binding site [ion binding]; other site 681288006809 molybdopterin cofactor binding site; other site 681288006810 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 681288006811 molybdopterin cofactor binding site; other site 681288006812 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 681288006813 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 681288006814 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 681288006815 active site 681288006816 Predicted transcriptional regulator [Transcription]; Region: COG2378 681288006817 HTH domain; Region: HTH_11; pfam08279 681288006818 CAAX protease self-immunity; Region: Abi; pfam02517 681288006819 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 681288006820 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 681288006821 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 681288006822 putative active site [active] 681288006823 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 681288006824 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 681288006825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288006826 active site 681288006827 motif I; other site 681288006828 motif II; other site 681288006829 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 681288006830 Sodium Bile acid symporter family; Region: SBF; pfam01758 681288006831 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 681288006832 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 681288006833 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288006834 active site turn [active] 681288006835 phosphorylation site [posttranslational modification] 681288006836 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 681288006837 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 681288006838 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 681288006839 putative active site [active] 681288006840 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 681288006841 putative hydrophobic ligand binding site [chemical binding]; other site 681288006842 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 681288006843 SAAV_2390 681288006844 oxidoreductase; Provisional; Region: PRK07985 681288006845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006846 NAD(P) binding site [chemical binding]; other site 681288006847 active site 681288006848 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 681288006849 amidohydrolase; Region: amidohydrolases; TIGR01891 681288006850 metal binding site [ion binding]; metal-binding site 681288006851 dimer interface [polypeptide binding]; other site 681288006852 imidazolonepropionase; Validated; Region: PRK09356 681288006853 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 681288006854 active site 681288006855 urocanate hydratase; Provisional; Region: PRK05414 681288006856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 681288006857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 681288006858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 681288006859 dimerization interface [polypeptide binding]; other site 681288006860 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 681288006861 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 681288006862 putative active site [active] 681288006863 putative Mg binding site [ion binding]; other site 681288006864 formimidoylglutamase; Provisional; Region: PRK13775 681288006865 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 681288006866 putative active site [active] 681288006867 putative metal binding site [ion binding]; other site 681288006868 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 681288006869 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 681288006870 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288006871 active site 681288006872 dimer interface [polypeptide binding]; other site 681288006873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 681288006874 MOSC domain; Region: MOSC; pfam03473 681288006875 3-alpha domain; Region: 3-alpha; pfam03475 681288006876 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 681288006877 active site 681288006878 catalytic residues [active] 681288006879 Uncharacterized conserved protein [Function unknown]; Region: COG1742 681288006880 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 681288006881 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 681288006882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288006883 Walker A/P-loop; other site 681288006884 ATP binding site [chemical binding]; other site 681288006885 Q-loop/lid; other site 681288006886 ABC transporter signature motif; other site 681288006887 Walker B; other site 681288006888 D-loop; other site 681288006889 H-loop/switch region; other site 681288006890 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 681288006891 Predicted membrane protein [Function unknown]; Region: COG3152 681288006892 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 681288006893 active site 681288006894 DNA binding site [nucleotide binding] 681288006895 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 681288006896 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 681288006897 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 681288006898 homotetramer interface [polypeptide binding]; other site 681288006899 FMN binding site [chemical binding]; other site 681288006900 homodimer contacts [polypeptide binding]; other site 681288006901 putative active site [active] 681288006902 putative substrate binding site [chemical binding]; other site 681288006903 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 681288006904 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 681288006905 oligomer interface [polypeptide binding]; other site 681288006906 metal binding site [ion binding]; metal-binding site 681288006907 metal binding site [ion binding]; metal-binding site 681288006908 putative Cl binding site [ion binding]; other site 681288006909 aspartate ring; other site 681288006910 basic sphincter; other site 681288006911 hydrophobic gate; other site 681288006912 periplasmic entrance; other site 681288006913 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 681288006914 active site 681288006915 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 681288006916 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 681288006917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006918 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 681288006919 putative substrate translocation pore; other site 681288006920 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 681288006921 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 681288006922 HlyD family secretion protein; Region: HlyD_3; pfam13437 681288006923 lipoyl-biotinyl attachment site [posttranslational modification]; other site 681288006924 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 681288006925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006926 putative substrate translocation pore; other site 681288006927 Predicted membrane protein [Function unknown]; Region: COG4640 681288006928 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 681288006929 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288006930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 681288006931 putative Zn2+ binding site [ion binding]; other site 681288006932 putative DNA binding site [nucleotide binding]; other site 681288006933 Uncharacterized conserved protein [Function unknown]; Region: COG1434 681288006934 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 681288006935 putative active site [active] 681288006936 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288006937 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 681288006938 Walker A/P-loop; other site 681288006939 ATP binding site [chemical binding]; other site 681288006940 Q-loop/lid; other site 681288006941 ABC transporter signature motif; other site 681288006942 Walker B; other site 681288006943 D-loop; other site 681288006944 H-loop/switch region; other site 681288006945 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 681288006946 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 681288006947 FtsX-like permease family; Region: FtsX; pfam02687 681288006948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288006949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288006950 active site 681288006951 phosphorylation site [posttranslational modification] 681288006952 intermolecular recognition site; other site 681288006953 dimerization interface [polypeptide binding]; other site 681288006954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288006955 DNA binding site [nucleotide binding] 681288006956 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 681288006957 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 681288006958 dimerization interface [polypeptide binding]; other site 681288006959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288006960 dimer interface [polypeptide binding]; other site 681288006961 phosphorylation site [posttranslational modification] 681288006962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288006963 ATP binding site [chemical binding]; other site 681288006964 Mg2+ binding site [ion binding]; other site 681288006965 G-X-G motif; other site 681288006966 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 681288006967 LytTr DNA-binding domain; Region: LytTR; smart00850 681288006968 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 681288006969 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 681288006970 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 681288006971 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 681288006972 L-lactate permease; Region: Lactate_perm; cl00701 681288006973 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 681288006974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288006975 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 681288006976 Coenzyme A binding pocket [chemical binding]; other site 681288006977 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 681288006978 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 681288006979 NAD(P) binding site [chemical binding]; other site 681288006980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288006981 Coenzyme A binding pocket [chemical binding]; other site 681288006982 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 681288006983 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 681288006984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288006985 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 681288006986 Predicted membrane protein [Function unknown]; Region: COG1511 681288006987 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 681288006988 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 681288006989 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 681288006990 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 681288006991 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 681288006992 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 681288006993 Cl binding site [ion binding]; other site 681288006994 oligomer interface [polypeptide binding]; other site 681288006995 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 681288006996 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288006997 active site turn [active] 681288006998 phosphorylation site [posttranslational modification] 681288006999 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 681288007000 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 681288007001 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 681288007002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288007003 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 681288007004 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 681288007005 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 681288007006 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 681288007007 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 681288007008 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288007009 MarR family; Region: MarR_2; pfam12802 681288007010 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 681288007011 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 681288007012 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 681288007013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007014 putative substrate translocation pore; other site 681288007015 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 681288007016 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 681288007017 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 681288007018 DNA binding residues [nucleotide binding] 681288007019 dimer interface [polypeptide binding]; other site 681288007020 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 681288007021 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 681288007022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288007023 active site 681288007024 phosphorylation site [posttranslational modification] 681288007025 intermolecular recognition site; other site 681288007026 dimerization interface [polypeptide binding]; other site 681288007027 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 681288007028 DNA binding residues [nucleotide binding] 681288007029 dimerization interface [polypeptide binding]; other site 681288007030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 681288007031 Histidine kinase; Region: HisKA_3; pfam07730 681288007032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288007033 ATP binding site [chemical binding]; other site 681288007034 Mg2+ binding site [ion binding]; other site 681288007035 G-X-G motif; other site 681288007036 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 681288007037 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 681288007038 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 681288007039 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 681288007040 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 681288007041 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 681288007042 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 681288007043 [4Fe-4S] binding site [ion binding]; other site 681288007044 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 681288007045 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 681288007046 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 681288007047 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 681288007048 molybdopterin cofactor binding site; other site 681288007049 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 681288007050 active site 681288007051 SAM binding site [chemical binding]; other site 681288007052 homodimer interface [polypeptide binding]; other site 681288007053 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 681288007054 [2Fe-2S] cluster binding site [ion binding]; other site 681288007055 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 681288007056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 681288007057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288007058 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 681288007059 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 681288007060 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 681288007061 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 681288007062 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 681288007063 putative active site [active] 681288007064 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 681288007065 active site 681288007066 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 681288007067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288007068 Coenzyme A binding pocket [chemical binding]; other site 681288007069 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 681288007070 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 681288007071 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 681288007072 putative hydrophobic ligand binding site [chemical binding]; other site 681288007073 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 681288007074 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 681288007075 intersubunit interface [polypeptide binding]; other site 681288007076 YodA lipocalin-like domain; Region: YodA; pfam09223 681288007077 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 681288007078 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 681288007079 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 681288007080 Thioredoxin; Region: Thioredoxin_4; cl17273 681288007081 FemAB family; Region: FemAB; pfam02388 681288007082 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 681288007083 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 681288007084 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 681288007085 Walker A/P-loop; other site 681288007086 ATP binding site [chemical binding]; other site 681288007087 Q-loop/lid; other site 681288007088 ABC transporter signature motif; other site 681288007089 Walker B; other site 681288007090 D-loop; other site 681288007091 H-loop/switch region; other site 681288007092 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 681288007093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288007094 dimer interface [polypeptide binding]; other site 681288007095 conserved gate region; other site 681288007096 putative PBP binding loops; other site 681288007097 ABC-ATPase subunit interface; other site 681288007098 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 681288007099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 681288007100 substrate binding pocket [chemical binding]; other site 681288007101 membrane-bound complex binding site; other site 681288007102 hinge residues; other site 681288007103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007104 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288007105 putative substrate translocation pore; other site 681288007106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007107 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 681288007108 catalytic core [active] 681288007109 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 681288007110 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 681288007111 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 681288007112 B domain; Region: B; pfam02216 681288007113 B domain; Region: B; pfam02216 681288007114 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 681288007115 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 681288007116 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 681288007117 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 681288007118 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 681288007119 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 681288007120 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 681288007121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288007122 catalytic residue [active] 681288007123 biotin synthase; Validated; Region: PRK06256 681288007124 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288007125 FeS/SAM binding site; other site 681288007126 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 681288007127 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288007128 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 681288007129 inhibitor-cofactor binding pocket; inhibition site 681288007130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288007131 catalytic residue [active] 681288007132 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 681288007133 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 681288007134 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 681288007135 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 681288007136 Walker A/P-loop; other site 681288007137 ATP binding site [chemical binding]; other site 681288007138 Q-loop/lid; other site 681288007139 ABC transporter signature motif; other site 681288007140 Walker B; other site 681288007141 D-loop; other site 681288007142 H-loop/switch region; other site 681288007143 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 681288007144 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 681288007145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288007146 Walker A/P-loop; other site 681288007147 ATP binding site [chemical binding]; other site 681288007148 Q-loop/lid; other site 681288007149 ABC transporter signature motif; other site 681288007150 Walker B; other site 681288007151 D-loop; other site 681288007152 H-loop/switch region; other site 681288007153 Predicted membrane protein [Function unknown]; Region: COG2246 681288007154 GtrA-like protein; Region: GtrA; pfam04138 681288007155 glycerate kinase; Region: TIGR00045 681288007156 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 681288007157 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 681288007158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007159 putative substrate translocation pore; other site 681288007160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 681288007161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 681288007162 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 681288007163 putative phosphoesterase; Region: acc_ester; TIGR03729 681288007164 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 681288007165 Spore germination protein; Region: Spore_permease; cl17796 681288007166 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 681288007167 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 681288007168 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 681288007169 Beta-lactamase; Region: Beta-lactamase; pfam00144 681288007170 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 681288007171 extended (e) SDRs; Region: SDR_e; cd08946 681288007172 NAD(P) binding site [chemical binding]; other site 681288007173 active site 681288007174 substrate binding site [chemical binding]; other site 681288007175 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 681288007176 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 681288007177 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 681288007178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007179 putative substrate translocation pore; other site 681288007180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288007182 dimer interface [polypeptide binding]; other site 681288007183 conserved gate region; other site 681288007184 ABC-ATPase subunit interface; other site 681288007185 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 681288007186 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 681288007187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288007188 dimer interface [polypeptide binding]; other site 681288007189 conserved gate region; other site 681288007190 putative PBP binding loops; other site 681288007191 ABC-ATPase subunit interface; other site 681288007192 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 681288007193 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 681288007194 Walker A/P-loop; other site 681288007195 ATP binding site [chemical binding]; other site 681288007196 Q-loop/lid; other site 681288007197 ABC transporter signature motif; other site 681288007198 Walker B; other site 681288007199 D-loop; other site 681288007200 H-loop/switch region; other site 681288007201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 681288007202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 681288007203 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 681288007204 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 681288007205 amino acid transporter; Region: 2A0306; TIGR00909 681288007206 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 681288007207 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 681288007208 substrate binding pocket [chemical binding]; other site 681288007209 catalytic triad [active] 681288007210 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 681288007211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007212 putative substrate translocation pore; other site 681288007213 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 681288007214 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 681288007215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288007216 Walker A/P-loop; other site 681288007217 ATP binding site [chemical binding]; other site 681288007218 Q-loop/lid; other site 681288007219 ABC transporter signature motif; other site 681288007220 Walker B; other site 681288007221 D-loop; other site 681288007222 H-loop/switch region; other site 681288007223 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 681288007224 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 681288007225 oligomer interface [polypeptide binding]; other site 681288007226 active site 681288007227 metal binding site [ion binding]; metal-binding site 681288007228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 681288007229 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 681288007230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 681288007231 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 681288007232 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 681288007233 active site 681288007234 FMN binding site [chemical binding]; other site 681288007235 substrate binding site [chemical binding]; other site 681288007236 3Fe-4S cluster binding site [ion binding]; other site 681288007237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007238 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288007239 putative substrate translocation pore; other site 681288007240 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 681288007241 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 681288007242 Walker A/P-loop; other site 681288007243 ATP binding site [chemical binding]; other site 681288007244 Q-loop/lid; other site 681288007245 ABC transporter signature motif; other site 681288007246 Walker B; other site 681288007247 D-loop; other site 681288007248 H-loop/switch region; other site 681288007249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 681288007250 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 681288007251 Walker A/P-loop; other site 681288007252 ATP binding site [chemical binding]; other site 681288007253 Q-loop/lid; other site 681288007254 ABC transporter signature motif; other site 681288007255 Walker B; other site 681288007256 D-loop; other site 681288007257 H-loop/switch region; other site 681288007258 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 681288007259 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 681288007260 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 681288007261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288007262 dimer interface [polypeptide binding]; other site 681288007263 conserved gate region; other site 681288007264 ABC-ATPase subunit interface; other site 681288007265 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 681288007266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288007267 dimer interface [polypeptide binding]; other site 681288007268 conserved gate region; other site 681288007269 putative PBP binding loops; other site 681288007270 ABC-ATPase subunit interface; other site 681288007271 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 681288007272 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 681288007273 substrate binding site [chemical binding]; other site 681288007274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 681288007275 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 681288007276 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 681288007277 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 681288007278 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 681288007279 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 681288007280 short chain dehydrogenase; Validated; Region: PRK08589 681288007281 classical (c) SDRs; Region: SDR_c; cd05233 681288007282 NAD(P) binding site [chemical binding]; other site 681288007283 active site 681288007284 AbgT putative transporter family; Region: ABG_transport; pfam03806 681288007285 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 681288007286 Uncharacterized conserved protein [Function unknown]; Region: COG2128 681288007287 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 681288007288 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 681288007289 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 681288007290 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 681288007291 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 681288007292 classical (c) SDRs; Region: SDR_c; cd05233 681288007293 NAD(P) binding site [chemical binding]; other site 681288007294 active site 681288007295 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 681288007296 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288007297 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288007298 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288007299 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288007300 Protein of unknown function, DUF576; Region: DUF576; pfam04507 681288007301 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 681288007302 PLD-like domain; Region: PLDc_2; pfam13091 681288007303 putative homodimer interface [polypeptide binding]; other site 681288007304 putative active site [active] 681288007305 catalytic site [active] 681288007306 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 681288007307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288007308 ATP binding site [chemical binding]; other site 681288007309 putative Mg++ binding site [ion binding]; other site 681288007310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288007311 nucleotide binding region [chemical binding]; other site 681288007312 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 681288007313 ATP-binding site [chemical binding]; other site 681288007314 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 681288007315 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 681288007316 active site 681288007317 8-oxo-dGMP binding site [chemical binding]; other site 681288007318 nudix motif; other site 681288007319 metal binding site [ion binding]; metal-binding site 681288007320 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 681288007321 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 681288007322 active site 681288007323 substrate binding site [chemical binding]; other site 681288007324 metal binding site [ion binding]; metal-binding site 681288007325 H+ Antiporter protein; Region: 2A0121; TIGR00900 681288007326 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 681288007327 legume lectins; Region: lectin_L-type; cl14058 681288007328 homotetramer interaction site [polypeptide binding]; other site 681288007329 carbohydrate binding site [chemical binding]; other site 681288007330 metal binding site [ion binding]; metal-binding site 681288007331 G5 domain; Region: G5; pfam07501 681288007332 G5 domain; Region: G5; pfam07501 681288007333 G5 domain; Region: G5; pfam07501 681288007334 G5 domain; Region: G5; pfam07501 681288007335 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 681288007336 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288007337 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288007338 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288007339 Transcriptional regulators [Transcription]; Region: MarR; COG1846 681288007340 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 681288007341 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 681288007342 tetramer interface; other site 681288007343 active site 681288007344 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288007345 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 681288007346 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288007347 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 681288007348 GntP family permease; Region: GntP_permease; pfam02447 681288007349 fructuronate transporter; Provisional; Region: PRK10034; cl15264 681288007350 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 681288007351 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 681288007352 N- and C-terminal domain interface [polypeptide binding]; other site 681288007353 active site 681288007354 catalytic site [active] 681288007355 metal binding site [ion binding]; metal-binding site 681288007356 carbohydrate binding site [chemical binding]; other site 681288007357 ATP binding site [chemical binding]; other site 681288007358 Transcriptional regulators [Transcription]; Region: GntR; COG1802 681288007359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288007360 DNA-binding site [nucleotide binding]; DNA binding site 681288007361 FCD domain; Region: FCD; pfam07729 681288007362 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 681288007363 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 681288007364 DNA binding residues [nucleotide binding] 681288007365 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 681288007366 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 681288007367 synthetase active site [active] 681288007368 NTP binding site [chemical binding]; other site 681288007369 metal binding site [ion binding]; metal-binding site 681288007370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 681288007371 Predicted membrane protein [Function unknown]; Region: COG1289 681288007372 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 681288007373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007374 D-galactonate transporter; Region: 2A0114; TIGR00893 681288007375 putative substrate translocation pore; other site 681288007376 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 681288007377 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 681288007378 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 681288007379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288007380 Walker A/P-loop; other site 681288007381 ATP binding site [chemical binding]; other site 681288007382 Q-loop/lid; other site 681288007383 ABC transporter signature motif; other site 681288007384 Walker B; other site 681288007385 D-loop; other site 681288007386 H-loop/switch region; other site 681288007387 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 681288007388 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 681288007389 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 681288007390 Uncharacterized membrane protein [Function unknown]; Region: COG3949 681288007391 Predicted esterase [General function prediction only]; Region: COG0400 681288007392 putative hydrolase; Provisional; Region: PRK11460 681288007393 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 681288007394 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 681288007395 Zn binding site [ion binding]; other site 681288007396 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 681288007397 Zn binding site [ion binding]; other site 681288007398 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288007399 MarR family; Region: MarR; pfam01047 681288007400 Predicted acetyltransferase [General function prediction only]; Region: COG2388 681288007401 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 681288007402 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 681288007403 putative metal binding site [ion binding]; other site 681288007404 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 681288007405 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 681288007406 dimer interface [polypeptide binding]; other site 681288007407 FMN binding site [chemical binding]; other site 681288007408 D-lactate dehydrogenase; Provisional; Region: PRK12480 681288007409 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 681288007410 homodimer interface [polypeptide binding]; other site 681288007411 ligand binding site [chemical binding]; other site 681288007412 NAD binding site [chemical binding]; other site 681288007413 catalytic site [active] 681288007414 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 681288007415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288007416 active site 681288007417 motif I; other site 681288007418 motif II; other site 681288007419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 681288007420 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 681288007421 Walker A/P-loop; other site 681288007422 ATP binding site [chemical binding]; other site 681288007423 Q-loop/lid; other site 681288007424 ABC transporter signature motif; other site 681288007425 Walker B; other site 681288007426 D-loop; other site 681288007427 H-loop/switch region; other site 681288007428 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 681288007429 active site 681288007430 catalytic site [active] 681288007431 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 681288007432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288007433 Coenzyme A binding pocket [chemical binding]; other site 681288007434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 681288007435 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 681288007436 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 681288007437 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 681288007438 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 681288007439 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 681288007440 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 681288007441 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 681288007442 EamA-like transporter family; Region: EamA; pfam00892 681288007443 EamA-like transporter family; Region: EamA; pfam00892 681288007444 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 681288007445 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 681288007446 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 681288007447 catalytic residues [active] 681288007448 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 681288007449 active site 681288007450 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 681288007451 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 681288007452 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288007453 active site turn [active] 681288007454 phosphorylation site [posttranslational modification] 681288007455 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 681288007456 HPr interaction site; other site 681288007457 glycerol kinase (GK) interaction site [polypeptide binding]; other site 681288007458 active site 681288007459 phosphorylation site [posttranslational modification] 681288007460 pyruvate oxidase; Provisional; Region: PRK08611 681288007461 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 681288007462 PYR/PP interface [polypeptide binding]; other site 681288007463 tetramer interface [polypeptide binding]; other site 681288007464 dimer interface [polypeptide binding]; other site 681288007465 TPP binding site [chemical binding]; other site 681288007466 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 681288007467 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 681288007468 TPP-binding site [chemical binding]; other site 681288007469 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 681288007470 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 681288007471 Transcriptional regulator [Transcription]; Region: LysR; COG0583 681288007472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 681288007473 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 681288007474 putative dimerization interface [polypeptide binding]; other site 681288007475 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 681288007476 Surface antigen [General function prediction only]; Region: COG3942 681288007477 CHAP domain; Region: CHAP; pfam05257 681288007478 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 681288007479 homodimer interface [polypeptide binding]; other site 681288007480 catalytic residues [active] 681288007481 NAD binding site [chemical binding]; other site 681288007482 substrate binding pocket [chemical binding]; other site 681288007483 flexible flap; other site 681288007484 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 681288007485 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 681288007486 dimer interface [polypeptide binding]; other site 681288007487 active site 681288007488 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 681288007489 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 681288007490 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 681288007491 DNA binding site [nucleotide binding] 681288007492 active site 681288007493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288007494 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 681288007495 Walker A motif; other site 681288007496 ATP binding site [chemical binding]; other site 681288007497 Walker B motif; other site 681288007498 arginine finger; other site 681288007499 UvrB/uvrC motif; Region: UVR; pfam02151 681288007500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288007501 Walker A motif; other site 681288007502 ATP binding site [chemical binding]; other site 681288007503 Walker B motif; other site 681288007504 arginine finger; other site 681288007505 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 681288007506 Virus attachment protein p12 family; Region: P12; pfam12669 681288007507 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 681288007508 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 681288007509 G1 box; other site 681288007510 GTP/Mg2+ binding site [chemical binding]; other site 681288007511 Switch I region; other site 681288007512 G2 box; other site 681288007513 G3 box; other site 681288007514 Switch II region; other site 681288007515 G4 box; other site 681288007516 G5 box; other site 681288007517 Nucleoside recognition; Region: Gate; pfam07670 681288007518 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 681288007519 Nucleoside recognition; Region: Gate; pfam07670 681288007520 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 681288007521 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 681288007522 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 681288007523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 681288007524 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 681288007525 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 681288007526 Glutamate binding site [chemical binding]; other site 681288007527 homodimer interface [polypeptide binding]; other site 681288007528 NAD binding site [chemical binding]; other site 681288007529 catalytic residues [active] 681288007530 maltose O-acetyltransferase; Provisional; Region: PRK10092 681288007531 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 681288007532 active site 681288007533 substrate binding site [chemical binding]; other site 681288007534 trimer interface [polypeptide binding]; other site 681288007535 CoA binding site [chemical binding]; other site 681288007536 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 681288007537 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 681288007538 metal-binding site [ion binding] 681288007539 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 681288007540 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 681288007541 metal-binding site [ion binding] 681288007542 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 681288007543 Soluble P-type ATPase [General function prediction only]; Region: COG4087 681288007544 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 681288007545 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 681288007546 metal-binding site [ion binding] 681288007547 D-lactate dehydrogenase; Validated; Region: PRK08605 681288007548 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 681288007549 homodimer interface [polypeptide binding]; other site 681288007550 ligand binding site [chemical binding]; other site 681288007551 NAD binding site [chemical binding]; other site 681288007552 catalytic site [active] 681288007553 transaminase; Reviewed; Region: PRK08068 681288007554 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288007555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288007556 homodimer interface [polypeptide binding]; other site 681288007557 catalytic residue [active] 681288007558 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 681288007559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 681288007560 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 681288007561 active site lid residues [active] 681288007562 substrate binding pocket [chemical binding]; other site 681288007563 catalytic residues [active] 681288007564 substrate-Mg2+ binding site; other site 681288007565 aspartate-rich region 1; other site 681288007566 aspartate-rich region 2; other site 681288007567 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 681288007568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 681288007569 active site 681288007570 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 681288007571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 681288007572 Surface antigen [General function prediction only]; Region: COG3942 681288007573 CHAP domain; Region: CHAP; pfam05257 681288007574 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 681288007575 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 681288007576 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 681288007577 catalytic triad [active] 681288007578 catalytic triad [active] 681288007579 oxyanion hole [active] 681288007580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288007581 Coenzyme A binding pocket [chemical binding]; other site 681288007582 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 681288007583 N-acetyl-D-glucosamine binding site [chemical binding]; other site 681288007584 catalytic residue [active] 681288007585 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 681288007586 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 681288007587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 681288007588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 681288007589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 681288007590 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 681288007591 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 681288007592 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 681288007593 NmrA-like family; Region: NmrA; pfam05368 681288007594 NADP binding site [chemical binding]; other site 681288007595 active site 681288007596 regulatory binding site [polypeptide binding]; other site 681288007597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 681288007598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 681288007599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 681288007600 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 681288007601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007602 NAD(P) binding site [chemical binding]; other site 681288007603 active site 681288007604 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 681288007605 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 681288007606 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 681288007607 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 681288007608 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 681288007609 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 681288007610 Nucleoside recognition; Region: Gate; pfam07670 681288007611 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 681288007612 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 681288007613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 681288007614 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 681288007615 Phosphotransferase enzyme family; Region: APH; pfam01636 681288007616 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 681288007617 active site 681288007618 ATP binding site [chemical binding]; other site 681288007619 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 681288007620 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 681288007621 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 681288007622 quinone interaction residues [chemical binding]; other site 681288007623 active site 681288007624 catalytic residues [active] 681288007625 FMN binding site [chemical binding]; other site 681288007626 substrate binding site [chemical binding]; other site 681288007627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 681288007628 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 681288007629 dimer interface [polypeptide binding]; other site 681288007630 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 681288007631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 681288007632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 681288007633 Predicted acyl esterases [General function prediction only]; Region: COG2936 681288007634 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 681288007635 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 681288007636 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 681288007637 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 681288007638 tetramerization interface [polypeptide binding]; other site 681288007639 active site 681288007640 pantoate--beta-alanine ligase; Region: panC; TIGR00018 681288007641 Pantoate-beta-alanine ligase; Region: PanC; cd00560 681288007642 active site 681288007643 ATP-binding site [chemical binding]; other site 681288007644 pantoate-binding site; other site 681288007645 HXXH motif; other site 681288007646 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 681288007647 oligomerization interface [polypeptide binding]; other site 681288007648 active site 681288007649 metal binding site [ion binding]; metal-binding site 681288007650 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 681288007651 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 681288007652 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 681288007653 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 681288007654 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 681288007655 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 681288007656 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288007657 NAD binding site [chemical binding]; other site 681288007658 dimer interface [polypeptide binding]; other site 681288007659 substrate binding site [chemical binding]; other site 681288007660 amino acid transporter; Region: 2A0306; TIGR00909 681288007661 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 681288007662 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 681288007663 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288007664 inhibitor-cofactor binding pocket; inhibition site 681288007665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288007666 catalytic residue [active] 681288007667 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 681288007668 catalytic residue [active] 681288007669 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 681288007670 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 681288007671 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 681288007672 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 681288007673 acyl-activating enzyme (AAE) consensus motif; other site 681288007674 AMP binding site [chemical binding]; other site 681288007675 active site 681288007676 CoA binding site [chemical binding]; other site 681288007677 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 681288007678 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 681288007679 choline dehydrogenase; Validated; Region: PRK02106 681288007680 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 681288007681 Predicted transcriptional regulators [Transcription]; Region: COG1510 681288007682 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 681288007683 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 681288007684 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288007685 FeS/SAM binding site; other site 681288007686 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 681288007687 Class III ribonucleotide reductase; Region: RNR_III; cd01675 681288007688 effector binding site; other site 681288007689 active site 681288007690 Zn binding site [ion binding]; other site 681288007691 glycine loop; other site 681288007692 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 681288007693 Citrate transporter; Region: CitMHS; pfam03600 681288007694 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 681288007695 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 681288007696 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 681288007697 Flavodoxin; Region: Flavodoxin_1; pfam00258 681288007698 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 681288007699 FAD binding pocket [chemical binding]; other site 681288007700 FAD binding motif [chemical binding]; other site 681288007701 catalytic residues [active] 681288007702 NAD binding pocket [chemical binding]; other site 681288007703 phosphate binding motif [ion binding]; other site 681288007704 beta-alpha-beta structure motif; other site 681288007705 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 681288007706 catalytic residues [active] 681288007707 dimer interface [polypeptide binding]; other site 681288007708 FtsX-like permease family; Region: FtsX; pfam02687 681288007709 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288007710 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 681288007711 Walker A/P-loop; other site 681288007712 ATP binding site [chemical binding]; other site 681288007713 Q-loop/lid; other site 681288007714 ABC transporter signature motif; other site 681288007715 Walker B; other site 681288007716 D-loop; other site 681288007717 H-loop/switch region; other site 681288007718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 681288007719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288007720 ATP binding site [chemical binding]; other site 681288007721 Mg2+ binding site [ion binding]; other site 681288007722 G-X-G motif; other site 681288007723 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288007724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288007725 active site 681288007726 phosphorylation site [posttranslational modification] 681288007727 intermolecular recognition site; other site 681288007728 dimerization interface [polypeptide binding]; other site 681288007729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288007730 DNA binding site [nucleotide binding] 681288007731 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 681288007732 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 681288007733 dimer interface [polypeptide binding]; other site 681288007734 active site 681288007735 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 681288007736 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 681288007737 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288007738 MarR family; Region: MarR_2; pfam12802 681288007739 Predicted esterase [General function prediction only]; Region: COG0627 681288007740 S-formylglutathione hydrolase; Region: PLN02442 681288007741 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 681288007742 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288007743 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 681288007744 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 681288007745 ligand binding site [chemical binding]; other site 681288007746 flexible hinge region; other site 681288007747 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 681288007748 carbamate kinase; Reviewed; Region: PRK12686 681288007749 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 681288007750 putative substrate binding site [chemical binding]; other site 681288007751 nucleotide binding site [chemical binding]; other site 681288007752 nucleotide binding site [chemical binding]; other site 681288007753 homodimer interface [polypeptide binding]; other site 681288007754 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 681288007755 ornithine carbamoyltransferase; Validated; Region: PRK02102 681288007756 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 681288007757 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 681288007758 arginine deiminase; Provisional; Region: PRK01388 681288007759 Arginine repressor [Transcription]; Region: ArgR; COG1438 681288007760 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 681288007761 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 681288007762 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 681288007763 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 681288007764 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 681288007765 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 681288007766 active site 681288007767 Zn binding site [ion binding]; other site 681288007768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288007769 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288007770 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 681288007771 HTH domain; Region: HTH_11; pfam08279 681288007772 PRD domain; Region: PRD; pfam00874 681288007773 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 681288007774 active site 681288007775 P-loop; other site 681288007776 phosphorylation site [posttranslational modification] 681288007777 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288007778 active site 681288007779 phosphorylation site [posttranslational modification] 681288007780 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 681288007781 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 681288007782 active site 681288007783 P-loop; other site 681288007784 phosphorylation site [posttranslational modification] 681288007785 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 681288007786 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288007787 active site 681288007788 phosphorylation site [posttranslational modification] 681288007789 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 681288007790 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 681288007791 Predicted membrane protein [Function unknown]; Region: COG1511 681288007792 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 681288007793 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 681288007794 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 681288007795 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 681288007796 CHAP domain; Region: CHAP; pfam05257 681288007797 Isochorismatase family; Region: Isochorismatase; pfam00857 681288007798 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 681288007799 catalytic triad [active] 681288007800 conserved cis-peptide bond; other site 681288007801 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 681288007802 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 681288007803 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 681288007804 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 681288007805 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 681288007806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 681288007807 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 681288007808 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 681288007809 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 681288007810 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 681288007811 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 681288007812 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 681288007813 SecY translocase; Region: SecY; pfam00344 681288007814 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 681288007815 legume lectins; Region: lectin_L-type; cd01951 681288007816 homotetramer interaction site [polypeptide binding]; other site 681288007817 carbohydrate binding site [chemical binding]; other site 681288007818 metal binding site [ion binding]; metal-binding site 681288007819 Putative Ig domain; Region: He_PIG; pfam05345 681288007820 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 681288007821 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 681288007822 methionine sulfoxide reductase A; Provisional; Region: PRK05528 681288007823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 681288007824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288007825 Coenzyme A binding pocket [chemical binding]; other site 681288007826 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 681288007827 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 681288007828 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 681288007829 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 681288007830 Chain length determinant protein; Region: Wzz; cl15801 681288007831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 681288007832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 681288007833 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 681288007834 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 681288007835 DXD motif; other site 681288007836 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 681288007837 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 681288007838 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 681288007839 Acyltransferase family; Region: Acyl_transf_3; pfam01757 681288007840 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 681288007841 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 681288007842 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 681288007843 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 681288007844 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 681288007845 metal binding site [ion binding]; metal-binding site 681288007846 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 681288007847 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 681288007848 substrate binding site [chemical binding]; other site 681288007849 glutamase interaction surface [polypeptide binding]; other site 681288007850 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 681288007851 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 681288007852 catalytic residues [active] 681288007853 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 681288007854 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 681288007855 putative active site [active] 681288007856 oxyanion strand; other site 681288007857 catalytic triad [active] 681288007858 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 681288007859 putative active site pocket [active] 681288007860 4-fold oligomerization interface [polypeptide binding]; other site 681288007861 metal binding residues [ion binding]; metal-binding site 681288007862 3-fold/trimer interface [polypeptide binding]; other site 681288007863 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 681288007864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288007865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288007866 homodimer interface [polypeptide binding]; other site 681288007867 catalytic residue [active] 681288007868 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 681288007869 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 681288007870 NAD binding site [chemical binding]; other site 681288007871 dimerization interface [polypeptide binding]; other site 681288007872 product binding site; other site 681288007873 substrate binding site [chemical binding]; other site 681288007874 zinc binding site [ion binding]; other site 681288007875 catalytic residues [active] 681288007876 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 681288007877 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 681288007878 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 681288007879 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 681288007880 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 681288007881 putative active site [active] 681288007882 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 681288007883 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 681288007884 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 681288007885 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 681288007886 Walker A/P-loop; other site 681288007887 ATP binding site [chemical binding]; other site 681288007888 Q-loop/lid; other site 681288007889 ABC transporter signature motif; other site 681288007890 Walker B; other site 681288007891 D-loop; other site 681288007892 H-loop/switch region; other site 681288007893 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 681288007894 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 681288007895 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 681288007896 Walker A/P-loop; other site 681288007897 ATP binding site [chemical binding]; other site 681288007898 Q-loop/lid; other site 681288007899 ABC transporter signature motif; other site 681288007900 Walker B; other site 681288007901 D-loop; other site 681288007902 H-loop/switch region; other site 681288007903 hypothetical protein; Provisional; Region: PRK13661 681288007904 Uncharacterized conserved protein [Function unknown]; Region: COG1912 681288007905 Uncharacterized conserved protein [Function unknown]; Region: COG2353 681288007906 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 681288007907 Strictosidine synthase; Region: Str_synth; pfam03088 681288007908 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 681288007909 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 681288007910 active site residue [active] 681288007911 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 681288007912 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 681288007913 putative substrate binding pocket [chemical binding]; other site 681288007914 AC domain interface; other site 681288007915 catalytic triad [active] 681288007916 AB domain interface; other site 681288007917 interchain disulfide; other site 681288007918 Predicted transcriptional regulators [Transcription]; Region: COG1695 681288007919 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 681288007920 DinB superfamily; Region: DinB_2; pfam12867 681288007921 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 681288007922 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 681288007923 transmembrane helices; other site 681288007924 Predicted permeases [General function prediction only]; Region: RarD; COG2962 681288007925 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 681288007926 hypothetical protein; Provisional; Region: PRK07758 681288007927 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 681288007928 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 681288007929 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 681288007930 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288007931 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 681288007932 Walker A/P-loop; other site 681288007933 ATP binding site [chemical binding]; other site 681288007934 Q-loop/lid; other site 681288007935 ABC transporter signature motif; other site 681288007936 Walker B; other site 681288007937 D-loop; other site 681288007938 H-loop/switch region; other site 681288007939 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 681288007940 FtsX-like permease family; Region: FtsX; pfam02687 681288007941 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 681288007942 DNA-binding site [nucleotide binding]; DNA binding site 681288007943 RNA-binding motif; other site 681288007944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 681288007945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288007946 non-specific DNA binding site [nucleotide binding]; other site 681288007947 salt bridge; other site 681288007948 sequence-specific DNA binding site [nucleotide binding]; other site 681288007949 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 681288007950 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 681288007951 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 681288007952 ParB-like nuclease domain; Region: ParBc; pfam02195 681288007953 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 681288007954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288007955 S-adenosylmethionine binding site [chemical binding]; other site 681288007956 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 681288007957 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 681288007958 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 681288007959 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 681288007960 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 681288007961 trmE is a tRNA modification GTPase; Region: trmE; cd04164 681288007962 G1 box; other site 681288007963 GTP/Mg2+ binding site [chemical binding]; other site 681288007964 Switch I region; other site 681288007965 G2 box; other site 681288007966 Switch II region; other site 681288007967 G3 box; other site 681288007968 G4 box; other site 681288007969 G5 box; other site 681288007970 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 681288007971 ribonuclease P; Reviewed; Region: rnpA; PRK00499 681288007972 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 681288007973 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 681288007974 Replication initiation factor; Region: Rep_trans; pfam02486 681288007975 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 681288007976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007977 putative substrate translocation pore; other site 681288007978 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 681288007979 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 681288007980 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 681288007981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288007982 non-specific DNA binding site [nucleotide binding]; other site 681288007983 salt bridge; other site 681288007984 sequence-specific DNA binding site [nucleotide binding]; other site 681288007985 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 681288007986 multiple promoter invertase; Provisional; Region: mpi; PRK13413 681288007987 catalytic residues [active] 681288007988 catalytic nucleophile [active] 681288007989 Presynaptic Site I dimer interface [polypeptide binding]; other site 681288007990 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 681288007991 Synaptic Flat tetramer interface [polypeptide binding]; other site 681288007992 Synaptic Site I dimer interface [polypeptide binding]; other site 681288007993 DNA binding site [nucleotide binding] 681288007994 Homeodomain-like domain; Region: HTH_23; pfam13384 681288007995 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 681288007996 catalytic nucleophile [active] 681288007997 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 681288007998 Integrase core domain; Region: rve; pfam00665 681288007999 Integrase core domain; Region: rve_3; pfam13683 681288008000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288008001 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288008002 Staphostatin A; Region: Staphostatin_A; pfam09022 681288008003 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 681288008004 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 681288008005 Integrase core domain; Region: rve_3; pfam13683 681288008006 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 681288008007 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 681288008008 P-loop; other site 681288008009 Magnesium ion binding site [ion binding]; other site 681288008010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 681288008011 Magnesium ion binding site [ion binding]; other site 681288008012 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 681288008013 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 681288008014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 681288008015 Integrase core domain; Region: rve; pfam00665 681288008016 CAAX protease self-immunity; Region: Abi; pfam02517 681288008017 PemK-like protein; Region: PemK; pfam02452 681288008018 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 681288008019 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 681288008020 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 681288008021 CAAX protease self-immunity; Region: Abi; pfam02517