-- dump date 20140620_073747 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1074252000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1074252000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1074252000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252000004 Walker A motif; other site 1074252000005 ATP binding site [chemical binding]; other site 1074252000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1074252000007 Walker B motif; other site 1074252000008 arginine finger; other site 1074252000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1074252000010 DnaA box-binding interface [nucleotide binding]; other site 1074252000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1074252000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1074252000013 putative DNA binding surface [nucleotide binding]; other site 1074252000014 dimer interface [polypeptide binding]; other site 1074252000015 beta-clamp/clamp loader binding surface; other site 1074252000016 beta-clamp/translesion DNA polymerase binding surface; other site 1074252000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1074252000018 recF protein; Region: recf; TIGR00611 1074252000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1074252000020 Walker A/P-loop; other site 1074252000021 ATP binding site [chemical binding]; other site 1074252000022 Q-loop/lid; other site 1074252000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1074252000024 ABC transporter signature motif; other site 1074252000025 Walker B; other site 1074252000026 D-loop; other site 1074252000027 H-loop/switch region; other site 1074252000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1074252000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252000030 Mg2+ binding site [ion binding]; other site 1074252000031 G-X-G motif; other site 1074252000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1074252000033 anchoring element; other site 1074252000034 dimer interface [polypeptide binding]; other site 1074252000035 ATP binding site [chemical binding]; other site 1074252000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1074252000037 active site 1074252000038 putative metal-binding site [ion binding]; other site 1074252000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1074252000040 DNA gyrase subunit A; Validated; Region: PRK05560 1074252000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1074252000042 CAP-like domain; other site 1074252000043 active site 1074252000044 primary dimer interface [polypeptide binding]; other site 1074252000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1074252000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1074252000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1074252000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1074252000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1074252000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1074252000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1074252000052 putative substrate binding site [chemical binding]; other site 1074252000053 putative ATP binding site [chemical binding]; other site 1074252000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1074252000055 active sites [active] 1074252000056 tetramer interface [polypeptide binding]; other site 1074252000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 1074252000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1074252000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1074252000060 dimer interface [polypeptide binding]; other site 1074252000061 active site 1074252000062 motif 1; other site 1074252000063 motif 2; other site 1074252000064 motif 3; other site 1074252000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1074252000066 Predicted membrane protein [Function unknown]; Region: COG4392 1074252000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1074252000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1074252000069 Predicted membrane protein [Function unknown]; Region: COG4241 1074252000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1074252000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1074252000072 DHH family; Region: DHH; pfam01368 1074252000073 DHHA1 domain; Region: DHHA1; pfam02272 1074252000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1074252000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1074252000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1074252000077 replicative DNA helicase; Region: DnaB; TIGR00665 1074252000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1074252000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1074252000080 Walker A motif; other site 1074252000081 ATP binding site [chemical binding]; other site 1074252000082 Walker B motif; other site 1074252000083 DNA binding loops [nucleotide binding] 1074252000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1074252000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1074252000086 GDP-binding site [chemical binding]; other site 1074252000087 ACT binding site; other site 1074252000088 IMP binding site; other site 1074252000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1074252000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252000091 active site 1074252000092 phosphorylation site [posttranslational modification] 1074252000093 intermolecular recognition site; other site 1074252000094 dimerization interface [polypeptide binding]; other site 1074252000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1074252000096 DNA binding site [nucleotide binding] 1074252000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1074252000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1074252000099 dimerization interface [polypeptide binding]; other site 1074252000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1074252000101 putative active site [active] 1074252000102 heme pocket [chemical binding]; other site 1074252000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1074252000104 dimer interface [polypeptide binding]; other site 1074252000105 phosphorylation site [posttranslational modification] 1074252000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252000107 ATP binding site [chemical binding]; other site 1074252000108 Mg2+ binding site [ion binding]; other site 1074252000109 G-X-G motif; other site 1074252000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1074252000111 YycH protein; Region: YycH; pfam07435 1074252000112 YycH protein; Region: YycI; cl02015 1074252000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1074252000114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1074252000115 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1074252000116 putative active site [active] 1074252000117 putative metal binding site [ion binding]; other site 1074252000118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1074252000119 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1074252000120 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1074252000121 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1074252000122 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1074252000123 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 1074252000124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1074252000125 Integrase core domain; Region: rve; pfam00665 1074252000127 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1074252000128 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1074252000129 putative active site [active] 1074252000130 catalytic site [active] 1074252000131 putative metal binding site [ion binding]; other site 1074252000132 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1074252000133 putative active site [active] 1074252000134 putative catalytic site [active] 1074252000135 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1074252000136 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1074252000137 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1074252000138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1074252000141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1074252000142 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1074252000143 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1074252000144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4333 1074252000145 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1074252000146 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1074252000147 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1074252000148 catalytic residues [active] 1074252000149 catalytic nucleophile [active] 1074252000150 Presynaptic Site I dimer interface [polypeptide binding]; other site 1074252000151 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1074252000152 Synaptic Flat tetramer interface [polypeptide binding]; other site 1074252000153 Synaptic Site I dimer interface [polypeptide binding]; other site 1074252000154 DNA binding site [nucleotide binding] 1074252000155 Recombinase; Region: Recombinase; pfam07508 1074252000156 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1074252000157 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 1074252000158 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1074252000159 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1074252000160 catalytic residues [active] 1074252000161 catalytic nucleophile [active] 1074252000162 Recombinase; Region: Recombinase; pfam07508 1074252000163 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1074252000164 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1074252000165 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1074252000166 cyclase homology domain; Region: CHD; cd07302 1074252000167 nucleotidyl binding site; other site 1074252000168 metal binding site [ion binding]; metal-binding site 1074252000169 dimer interface [polypeptide binding]; other site 1074252000170 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1074252000171 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1074252000172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252000173 S-adenosylmethionine binding site [chemical binding]; other site 1074252000174 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1074252000175 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1074252000176 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1074252000177 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1074252000178 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1074252000179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252000180 ATP binding site [chemical binding]; other site 1074252000181 putative Mg++ binding site [ion binding]; other site 1074252000182 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1074252000184 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1074252000185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000186 putative substrate translocation pore; other site 1074252000187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1074252000189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1074252000190 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1074252000191 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1074252000192 FMN binding site [chemical binding]; other site 1074252000193 active site 1074252000194 catalytic residues [active] 1074252000195 substrate binding site [chemical binding]; other site 1074252000196 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1074252000197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000198 H+ Antiporter protein; Region: 2A0121; TIGR00900 1074252000199 putative substrate translocation pore; other site 1074252000200 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1074252000201 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1074252000202 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1074252000203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1074252000204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1074252000205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1074252000206 dimerization interface [polypeptide binding]; other site 1074252000207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1074252000208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1074252000209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1074252000210 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1074252000211 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1074252000212 Part of AAA domain; Region: AAA_19; pfam13245 1074252000213 AAA domain; Region: AAA_12; pfam13087 1074252000214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1074252000215 Integrase core domain; Region: rve; pfam00665 1074252000216 transposase/IS protein; Provisional; Region: PRK09183 1074252000217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252000218 Walker A motif; other site 1074252000219 ATP binding site [chemical binding]; other site 1074252000220 Walker B motif; other site 1074252000221 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1074252000222 active site 1074252000223 catalytic site [active] 1074252000224 putative metal binding site [ion binding]; other site 1074252000225 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252000226 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252000227 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1074252000228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1074252000229 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1074252000230 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1074252000231 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1074252000232 metal binding site [ion binding]; metal-binding site 1074252000233 dimer interface [polypeptide binding]; other site 1074252000234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252000236 putative substrate translocation pore; other site 1074252000237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000238 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1074252000239 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1074252000240 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1074252000241 PhoU domain; Region: PhoU; pfam01895 1074252000242 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1074252000243 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1074252000244 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1074252000245 L-lactate permease; Region: Lactate_perm; cl00701 1074252000247 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252000248 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1074252000249 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252000250 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1074252000251 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1074252000252 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252000253 ABC-ATPase subunit interface; other site 1074252000254 dimer interface [polypeptide binding]; other site 1074252000255 putative PBP binding regions; other site 1074252000256 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1074252000257 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252000258 ABC-ATPase subunit interface; other site 1074252000259 dimer interface [polypeptide binding]; other site 1074252000260 putative PBP binding regions; other site 1074252000261 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1074252000262 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1074252000263 siderophore binding site; other site 1074252000264 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1074252000265 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1074252000266 dimer interface [polypeptide binding]; other site 1074252000267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252000268 catalytic residue [active] 1074252000269 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1074252000270 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1074252000271 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1074252000272 IucA / IucC family; Region: IucA_IucC; pfam04183 1074252000273 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1074252000274 drug efflux system protein MdtG; Provisional; Region: PRK09874 1074252000275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000276 putative substrate translocation pore; other site 1074252000277 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1074252000278 IucA / IucC family; Region: IucA_IucC; pfam04183 1074252000279 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1074252000280 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1074252000281 IucA / IucC family; Region: IucA_IucC; pfam04183 1074252000282 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1074252000283 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1074252000284 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1074252000285 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1074252000286 dimer interface [polypeptide binding]; other site 1074252000287 active site 1074252000288 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1074252000289 catalytic residues [active] 1074252000290 substrate binding site [chemical binding]; other site 1074252000291 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1074252000292 ParB-like nuclease domain; Region: ParBc; pfam02195 1074252000293 acetoin reductase; Validated; Region: PRK08643 1074252000294 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1074252000295 NAD binding site [chemical binding]; other site 1074252000296 homotetramer interface [polypeptide binding]; other site 1074252000297 homodimer interface [polypeptide binding]; other site 1074252000298 active site 1074252000299 substrate binding site [chemical binding]; other site 1074252000300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1074252000301 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1074252000302 NAD(P) binding site [chemical binding]; other site 1074252000303 active site 1074252000304 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1074252000305 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1074252000306 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1074252000307 putative ADP-binding pocket [chemical binding]; other site 1074252000308 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1074252000309 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1074252000310 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1074252000311 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1074252000312 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1074252000313 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1074252000314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1074252000315 DNA-binding site [nucleotide binding]; DNA binding site 1074252000317 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252000318 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1074252000319 intersubunit interface [polypeptide binding]; other site 1074252000320 active site 1074252000321 catalytic residue [active] 1074252000322 phosphopentomutase; Provisional; Region: PRK05362 1074252000323 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1074252000324 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1074252000325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252000326 dimer interface [polypeptide binding]; other site 1074252000327 conserved gate region; other site 1074252000328 putative PBP binding loops; other site 1074252000329 ABC-ATPase subunit interface; other site 1074252000330 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1074252000331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252000332 dimer interface [polypeptide binding]; other site 1074252000333 conserved gate region; other site 1074252000334 ABC-ATPase subunit interface; other site 1074252000335 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1074252000336 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1074252000337 Walker A/P-loop; other site 1074252000338 ATP binding site [chemical binding]; other site 1074252000339 Q-loop/lid; other site 1074252000340 ABC transporter signature motif; other site 1074252000341 Walker B; other site 1074252000342 D-loop; other site 1074252000343 H-loop/switch region; other site 1074252000344 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1074252000345 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1074252000346 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1074252000347 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1074252000348 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1074252000349 active site 1074252000350 metal binding site [ion binding]; metal-binding site 1074252000351 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1074252000352 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1074252000353 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1074252000354 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1074252000355 putative catalytic cysteine [active] 1074252000356 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1074252000357 putative active site [active] 1074252000358 metal binding site [ion binding]; metal-binding site 1074252000359 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1074252000360 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1074252000361 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 1074252000362 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1074252000363 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1074252000364 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1074252000365 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1074252000366 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1074252000367 NAD(P) binding site [chemical binding]; other site 1074252000368 homodimer interface [polypeptide binding]; other site 1074252000369 substrate binding site [chemical binding]; other site 1074252000370 active site 1074252000371 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1074252000372 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1074252000373 NAD(P) binding site [chemical binding]; other site 1074252000374 homodimer interface [polypeptide binding]; other site 1074252000375 substrate binding site [chemical binding]; other site 1074252000376 active site 1074252000377 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1074252000378 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1074252000379 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1074252000380 putative NAD(P) binding site [chemical binding]; other site 1074252000381 active site 1074252000382 putative substrate binding site [chemical binding]; other site 1074252000383 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1074252000384 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1074252000385 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1074252000386 active site 1074252000387 homodimer interface [polypeptide binding]; other site 1074252000388 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1074252000389 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1074252000390 trimer interface [polypeptide binding]; other site 1074252000391 active site 1074252000392 substrate binding site [chemical binding]; other site 1074252000393 CoA binding site [chemical binding]; other site 1074252000394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1074252000395 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1074252000396 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1074252000397 O-Antigen ligase; Region: Wzy_C; pfam04932 1074252000398 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1074252000399 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1074252000400 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1074252000401 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1074252000402 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1074252000403 putative NAD(P) binding site [chemical binding]; other site 1074252000404 active site 1074252000405 putative substrate binding site [chemical binding]; other site 1074252000406 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1074252000407 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1074252000408 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1074252000409 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1074252000410 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1074252000411 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1074252000412 active site 1074252000413 homodimer interface [polypeptide binding]; other site 1074252000414 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 1074252000415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1074252000416 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 1074252000417 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1074252000418 NAD(P) binding site [chemical binding]; other site 1074252000419 catalytic residues [active] 1074252000420 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1074252000421 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1074252000422 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1074252000423 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1074252000424 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1074252000425 Walker A/P-loop; other site 1074252000426 ATP binding site [chemical binding]; other site 1074252000427 Q-loop/lid; other site 1074252000428 ABC transporter signature motif; other site 1074252000429 Walker B; other site 1074252000430 D-loop; other site 1074252000431 H-loop/switch region; other site 1074252000432 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1074252000433 NMT1-like family; Region: NMT1_2; pfam13379 1074252000434 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1074252000435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1074252000437 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1074252000439 putative transporter; Provisional; Region: PRK10054 1074252000440 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1074252000441 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1074252000442 acyl-activating enzyme (AAE) consensus motif; other site 1074252000443 AMP binding site [chemical binding]; other site 1074252000444 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1074252000445 Condensation domain; Region: Condensation; pfam00668 1074252000446 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1074252000447 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1074252000448 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1074252000449 acyl-activating enzyme (AAE) consensus motif; other site 1074252000450 AMP binding site [chemical binding]; other site 1074252000451 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1074252000452 thioester reductase domain; Region: Thioester-redct; TIGR01746 1074252000453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1074252000454 NAD(P) binding site [chemical binding]; other site 1074252000455 active site 1074252000456 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1074252000457 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1074252000458 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1074252000459 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1074252000460 nucleotide binding site [chemical binding]; other site 1074252000461 N-acetyl-L-glutamate binding site [chemical binding]; other site 1074252000462 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1074252000463 heterotetramer interface [polypeptide binding]; other site 1074252000464 active site pocket [active] 1074252000465 cleavage site 1074252000466 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1074252000467 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1074252000468 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1074252000469 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1074252000470 inhibitor-cofactor binding pocket; inhibition site 1074252000471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252000472 catalytic residue [active] 1074252000473 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1074252000474 Isochorismatase family; Region: Isochorismatase; pfam00857 1074252000475 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1074252000476 catalytic triad [active] 1074252000477 conserved cis-peptide bond; other site 1074252000478 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1074252000479 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1074252000480 dimer interface [polypeptide binding]; other site 1074252000481 PYR/PP interface [polypeptide binding]; other site 1074252000482 TPP binding site [chemical binding]; other site 1074252000483 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1074252000484 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1074252000485 TPP-binding site [chemical binding]; other site 1074252000486 dimer interface [polypeptide binding]; other site 1074252000487 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1074252000488 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1074252000489 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1074252000490 active site turn [active] 1074252000491 phosphorylation site [posttranslational modification] 1074252000492 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1074252000493 HPr interaction site; other site 1074252000494 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1074252000495 active site 1074252000496 phosphorylation site [posttranslational modification] 1074252000497 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1074252000498 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1074252000499 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 1074252000500 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1074252000501 putative active site [active] 1074252000502 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1074252000503 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1074252000504 active site turn [active] 1074252000505 phosphorylation site [posttranslational modification] 1074252000506 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1074252000507 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1074252000508 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1074252000509 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1074252000510 putative active site [active] 1074252000511 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1074252000512 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1074252000513 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252000514 ATP binding site [chemical binding]; other site 1074252000515 putative Mg++ binding site [ion binding]; other site 1074252000516 RES domain; Region: RES; pfam08808 1074252000517 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1074252000518 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1074252000519 Walker A/P-loop; other site 1074252000520 ATP binding site [chemical binding]; other site 1074252000521 Q-loop/lid; other site 1074252000522 ABC transporter signature motif; other site 1074252000523 Walker B; other site 1074252000524 D-loop; other site 1074252000525 H-loop/switch region; other site 1074252000526 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1074252000527 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1074252000528 Walker A/P-loop; other site 1074252000529 ATP binding site [chemical binding]; other site 1074252000530 Q-loop/lid; other site 1074252000531 ABC transporter signature motif; other site 1074252000532 Walker B; other site 1074252000533 D-loop; other site 1074252000534 H-loop/switch region; other site 1074252000535 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1074252000536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252000537 dimer interface [polypeptide binding]; other site 1074252000538 conserved gate region; other site 1074252000539 putative PBP binding loops; other site 1074252000540 ABC-ATPase subunit interface; other site 1074252000541 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1074252000542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252000543 dimer interface [polypeptide binding]; other site 1074252000544 conserved gate region; other site 1074252000545 ABC-ATPase subunit interface; other site 1074252000546 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1074252000547 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1074252000548 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1074252000549 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1074252000550 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1074252000551 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 1074252000552 azoreductase; Reviewed; Region: PRK00170 1074252000553 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1074252000554 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1074252000555 Peptidase family M23; Region: Peptidase_M23; pfam01551 1074252000556 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1074252000557 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1074252000558 Walker A/P-loop; other site 1074252000559 ATP binding site [chemical binding]; other site 1074252000560 Q-loop/lid; other site 1074252000561 ABC transporter signature motif; other site 1074252000562 Walker B; other site 1074252000563 D-loop; other site 1074252000564 H-loop/switch region; other site 1074252000565 TOBE domain; Region: TOBE; pfam03459 1074252000566 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1074252000567 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1074252000568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252000569 dimer interface [polypeptide binding]; other site 1074252000570 conserved gate region; other site 1074252000571 ABC-ATPase subunit interface; other site 1074252000572 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1074252000573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252000574 dimer interface [polypeptide binding]; other site 1074252000575 conserved gate region; other site 1074252000576 putative PBP binding loops; other site 1074252000577 ABC-ATPase subunit interface; other site 1074252000578 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1074252000579 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1074252000580 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1074252000581 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1074252000582 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1074252000583 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1074252000584 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1074252000585 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1074252000586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1074252000587 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1074252000588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000589 putative substrate translocation pore; other site 1074252000590 Response regulator receiver domain; Region: Response_reg; pfam00072 1074252000591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252000592 active site 1074252000593 phosphorylation site [posttranslational modification] 1074252000594 intermolecular recognition site; other site 1074252000595 dimerization interface [polypeptide binding]; other site 1074252000596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1074252000597 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1074252000598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1074252000599 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1074252000600 Histidine kinase; Region: His_kinase; pfam06580 1074252000601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252000602 ATP binding site [chemical binding]; other site 1074252000603 Mg2+ binding site [ion binding]; other site 1074252000604 G-X-G motif; other site 1074252000605 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1074252000606 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1074252000607 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1074252000608 Pyruvate formate lyase 1; Region: PFL1; cd01678 1074252000609 coenzyme A binding site [chemical binding]; other site 1074252000610 active site 1074252000611 catalytic residues [active] 1074252000612 glycine loop; other site 1074252000613 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1074252000614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1074252000615 FeS/SAM binding site; other site 1074252000616 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1074252000617 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1074252000618 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1074252000619 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1074252000620 putative active site [active] 1074252000621 catalytic site [active] 1074252000622 putative metal binding site [ion binding]; other site 1074252000623 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1074252000624 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1074252000625 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1074252000626 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1074252000627 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1074252000628 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1074252000629 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1074252000630 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1074252000631 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1074252000632 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1074252000633 dimer interface [polypeptide binding]; other site 1074252000634 active site 1074252000635 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1074252000636 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1074252000637 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1074252000638 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1074252000639 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1074252000640 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1074252000641 substrate binding site [chemical binding]; other site 1074252000642 oxyanion hole (OAH) forming residues; other site 1074252000643 trimer interface [polypeptide binding]; other site 1074252000644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1074252000645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1074252000646 active site 1074252000647 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1074252000648 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1074252000649 acyl-activating enzyme (AAE) consensus motif; other site 1074252000650 AMP binding site [chemical binding]; other site 1074252000651 active site 1074252000652 CoA binding site [chemical binding]; other site 1074252000653 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1074252000654 Coenzyme A transferase; Region: CoA_trans; smart00882 1074252000655 Coenzyme A transferase; Region: CoA_trans; cl17247 1074252000656 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1074252000657 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1074252000658 catalytic triad [active] 1074252000659 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1074252000660 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1074252000661 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1074252000662 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1074252000663 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1074252000664 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1074252000665 heme-binding site [chemical binding]; other site 1074252000666 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1074252000667 FAD binding pocket [chemical binding]; other site 1074252000668 FAD binding motif [chemical binding]; other site 1074252000669 phosphate binding motif [ion binding]; other site 1074252000670 beta-alpha-beta structure motif; other site 1074252000671 NAD binding pocket [chemical binding]; other site 1074252000672 Heme binding pocket [chemical binding]; other site 1074252000673 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1074252000674 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1074252000675 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1074252000676 NAD binding site [chemical binding]; other site 1074252000677 dimer interface [polypeptide binding]; other site 1074252000678 substrate binding site [chemical binding]; other site 1074252000679 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1074252000680 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1074252000681 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1074252000682 active site turn [active] 1074252000683 phosphorylation site [posttranslational modification] 1074252000684 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1074252000685 active site 1074252000686 tetramer interface [polypeptide binding]; other site 1074252000687 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1074252000688 Mga helix-turn-helix domain; Region: Mga; pfam05043 1074252000689 PRD domain; Region: PRD; pfam00874 1074252000690 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1074252000691 active site 1074252000692 P-loop; other site 1074252000693 phosphorylation site [posttranslational modification] 1074252000694 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1074252000695 active site 1074252000696 phosphorylation site [posttranslational modification] 1074252000697 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1074252000698 active site 1074252000699 phosphorylation site [posttranslational modification] 1074252000700 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1074252000701 active site 1074252000702 P-loop; other site 1074252000703 phosphorylation site [posttranslational modification] 1074252000704 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1074252000705 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1074252000706 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1074252000707 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1074252000708 putative NAD(P) binding site [chemical binding]; other site 1074252000709 catalytic Zn binding site [ion binding]; other site 1074252000710 structural Zn binding site [ion binding]; other site 1074252000711 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1074252000712 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1074252000713 putative NAD(P) binding site [chemical binding]; other site 1074252000714 catalytic Zn binding site [ion binding]; other site 1074252000715 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1074252000716 substrate binding site; other site 1074252000717 dimer interface; other site 1074252000718 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1074252000719 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1074252000720 putative NAD(P) binding site [chemical binding]; other site 1074252000721 putative catalytic Zn binding site [ion binding]; other site 1074252000722 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1074252000723 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1074252000724 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1074252000725 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1074252000726 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1074252000727 substrate binding site; other site 1074252000728 dimer interface; other site 1074252000729 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1074252000730 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1074252000731 putative NAD(P) binding site [chemical binding]; other site 1074252000732 putative catalytic Zn binding site [ion binding]; other site 1074252000733 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1074252000734 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1074252000735 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1074252000736 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1074252000737 active site 1074252000738 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 1074252000739 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1074252000740 Hemerythrin-like domain; Region: Hr-like; cd12108 1074252000741 Fe binding site [ion binding]; other site 1074252000742 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1074252000743 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1074252000744 Histidine kinase; Region: His_kinase; pfam06580 1074252000745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252000746 Mg2+ binding site [ion binding]; other site 1074252000747 G-X-G motif; other site 1074252000748 two-component response regulator; Provisional; Region: PRK14084 1074252000749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252000750 active site 1074252000751 phosphorylation site [posttranslational modification] 1074252000752 intermolecular recognition site; other site 1074252000753 dimerization interface [polypeptide binding]; other site 1074252000754 LytTr DNA-binding domain; Region: LytTR; pfam04397 1074252000755 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1074252000756 antiholin-like protein LrgB; Provisional; Region: PRK04288 1074252000757 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1074252000758 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1074252000759 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1074252000760 Putative water exit pathway; other site 1074252000761 Putative proton exit pathway; other site 1074252000762 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1074252000763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1074252000764 DNA-binding site [nucleotide binding]; DNA binding site 1074252000765 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1074252000766 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1074252000767 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1074252000768 HPr interaction site; other site 1074252000769 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1074252000770 active site 1074252000771 phosphorylation site [posttranslational modification] 1074252000772 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1074252000773 beta-galactosidase; Region: BGL; TIGR03356 1074252000774 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1074252000775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252000776 S-adenosylmethionine binding site [chemical binding]; other site 1074252000777 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1074252000778 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1074252000779 substrate binding site [chemical binding]; other site 1074252000780 dimer interface [polypeptide binding]; other site 1074252000781 ATP binding site [chemical binding]; other site 1074252000782 D-ribose pyranase; Provisional; Region: PRK11797 1074252000783 Sugar transport protein; Region: Sugar_transport; pfam06800 1074252000784 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1074252000785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1074252000786 DNA binding site [nucleotide binding] 1074252000787 domain linker motif; other site 1074252000788 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1074252000789 dimerization interface [polypeptide binding]; other site 1074252000790 ligand binding site [chemical binding]; other site 1074252000791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000793 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1074252000794 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1074252000795 active site 1074252000796 Surface antigen [General function prediction only]; Region: COG3942 1074252000797 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1074252000798 Peptidase family M23; Region: Peptidase_M23; pfam01551 1074252000799 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1074252000800 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1074252000801 Walker A/P-loop; other site 1074252000802 ATP binding site [chemical binding]; other site 1074252000803 Q-loop/lid; other site 1074252000804 ABC transporter signature motif; other site 1074252000805 Walker B; other site 1074252000806 D-loop; other site 1074252000807 H-loop/switch region; other site 1074252000808 Surface antigen [General function prediction only]; Region: COG3942 1074252000809 CHAP domain; Region: CHAP; pfam05257 1074252000810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1074252000811 Predicted membrane protein [Function unknown]; Region: COG1511 1074252000812 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1074252000813 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1074252000814 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1074252000815 Uncharacterized small protein [Function unknown]; Region: COG5417 1074252000816 Predicted membrane protein [Function unknown]; Region: COG4499 1074252000817 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1074252000818 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1074252000819 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1074252000820 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1074252000821 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1074252000822 LXG domain of WXG superfamily; Region: LXG; pfam04740 1074252000823 transposase/IS protein; Provisional; Region: PRK09183 1074252000824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252000825 Walker A motif; other site 1074252000826 ATP binding site [chemical binding]; other site 1074252000827 Walker B motif; other site 1074252000828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1074252000829 Integrase core domain; Region: rve; pfam00665 1074252000830 Protein of unknown function, DUF600; Region: DUF600; cl04640 1074252000831 Protein of unknown function, DUF600; Region: DUF600; cl04640 1074252000832 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1074252000833 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1074252000834 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1074252000835 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 1074252000836 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1074252000837 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1074252000838 FtsX-like permease family; Region: FtsX; pfam02687 1074252000839 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1074252000840 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1074252000841 Walker A/P-loop; other site 1074252000842 ATP binding site [chemical binding]; other site 1074252000843 Q-loop/lid; other site 1074252000844 ABC transporter signature motif; other site 1074252000845 Walker B; other site 1074252000846 D-loop; other site 1074252000847 H-loop/switch region; other site 1074252000848 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1074252000849 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1074252000850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1074252000851 non-specific DNA binding site [nucleotide binding]; other site 1074252000852 salt bridge; other site 1074252000853 sequence-specific DNA binding site [nucleotide binding]; other site 1074252000854 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1074252000855 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1074252000856 substrate binding site [chemical binding]; other site 1074252000857 ATP binding site [chemical binding]; other site 1074252000858 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1074252000859 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1074252000860 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1074252000861 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1074252000862 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1074252000863 putative transporter; Provisional; Region: PRK10484 1074252000864 Na binding site [ion binding]; other site 1074252000865 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1074252000866 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1074252000867 inhibitor site; inhibition site 1074252000868 active site 1074252000869 dimer interface [polypeptide binding]; other site 1074252000870 catalytic residue [active] 1074252000871 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1074252000872 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1074252000873 nucleotide binding site [chemical binding]; other site 1074252000874 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1074252000875 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1074252000876 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1074252000877 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1074252000878 putative active site [active] 1074252000879 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1074252000880 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1074252000881 putative active site cavity [active] 1074252000882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1074252000883 Nucleoside recognition; Region: Gate; pfam07670 1074252000884 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1074252000885 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1074252000886 PGAP1-like protein; Region: PGAP1; pfam07819 1074252000887 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1074252000888 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1074252000889 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1074252000890 putative active site [active] 1074252000891 putative FMN binding site [chemical binding]; other site 1074252000892 putative substrate binding site [chemical binding]; other site 1074252000893 putative catalytic residue [active] 1074252000894 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1074252000895 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1074252000896 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1074252000897 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1074252000898 lipoyl attachment site [posttranslational modification]; other site 1074252000899 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1074252000900 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1074252000901 putative ADP-ribose binding site [chemical binding]; other site 1074252000902 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1074252000903 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1074252000904 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1074252000905 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1074252000906 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1074252000907 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1074252000908 NADP binding site [chemical binding]; other site 1074252000909 putative substrate binding site [chemical binding]; other site 1074252000910 active site 1074252000911 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1074252000912 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1074252000913 active site 1074252000914 P-loop; other site 1074252000915 phosphorylation site [posttranslational modification] 1074252000916 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1074252000917 active site 1074252000918 phosphorylation site [posttranslational modification] 1074252000919 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1074252000920 HTH domain; Region: HTH_11; pfam08279 1074252000921 HTH domain; Region: HTH_11; pfam08279 1074252000922 PRD domain; Region: PRD; pfam00874 1074252000923 PRD domain; Region: PRD; pfam00874 1074252000924 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1074252000925 active site 1074252000926 P-loop; other site 1074252000927 phosphorylation site [posttranslational modification] 1074252000928 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1074252000929 active site 1074252000930 phosphorylation site [posttranslational modification] 1074252000931 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1074252000932 MarR family; Region: MarR_2; pfam12802 1074252000933 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1074252000934 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1074252000935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 1074252000936 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1074252000937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000938 putative substrate translocation pore; other site 1074252000939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252000940 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1074252000941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1074252000942 Zn binding site [ion binding]; other site 1074252000943 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1074252000944 Zn binding site [ion binding]; other site 1074252000945 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1074252000946 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1074252000947 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1074252000948 Predicted flavoprotein [General function prediction only]; Region: COG0431 1074252000949 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1074252000950 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1074252000951 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1074252000952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1074252000953 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1074252000954 Imelysin; Region: Peptidase_M75; pfam09375 1074252000956 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1074252000957 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1074252000958 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1074252000959 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1074252000960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1074252000961 non-specific DNA binding site [nucleotide binding]; other site 1074252000962 salt bridge; other site 1074252000963 sequence-specific DNA binding site [nucleotide binding]; other site 1074252000964 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1074252000965 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1074252000966 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1074252000967 Walker A/P-loop; other site 1074252000968 ATP binding site [chemical binding]; other site 1074252000969 Q-loop/lid; other site 1074252000970 ABC transporter signature motif; other site 1074252000971 Walker B; other site 1074252000972 D-loop; other site 1074252000973 H-loop/switch region; other site 1074252000974 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1074252000975 Predicted membrane protein [Function unknown]; Region: COG4292 1074252000976 putative acyltransferase; Provisional; Region: PRK05790 1074252000977 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1074252000978 dimer interface [polypeptide binding]; other site 1074252000979 active site 1074252000980 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1074252000981 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1074252000982 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1074252000983 THF binding site; other site 1074252000984 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1074252000985 substrate binding site [chemical binding]; other site 1074252000986 THF binding site; other site 1074252000987 zinc-binding site [ion binding]; other site 1074252000988 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1074252000989 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1074252000990 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1074252000991 FAD binding site [chemical binding]; other site 1074252000992 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1074252000993 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1074252000994 homodimer interface [polypeptide binding]; other site 1074252000995 substrate-cofactor binding pocket; other site 1074252000996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252000997 catalytic residue [active] 1074252000998 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1074252000999 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1074252001000 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1074252001001 catalytic residue [active] 1074252001002 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1074252001003 ParB-like nuclease domain; Region: ParB; smart00470 1074252001004 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1074252001005 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1074252001006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 1074252001007 GTP-binding protein YchF; Reviewed; Region: PRK09601 1074252001008 YchF GTPase; Region: YchF; cd01900 1074252001009 G1 box; other site 1074252001010 GTP/Mg2+ binding site [chemical binding]; other site 1074252001011 Switch I region; other site 1074252001012 G2 box; other site 1074252001013 Switch II region; other site 1074252001014 G3 box; other site 1074252001015 G4 box; other site 1074252001016 G5 box; other site 1074252001017 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1074252001018 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1074252001019 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1074252001020 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1074252001021 dimer interface [polypeptide binding]; other site 1074252001022 ssDNA binding site [nucleotide binding]; other site 1074252001023 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1074252001024 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1074252001025 Abi-like protein; Region: Abi_2; pfam07751 1074252001026 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252001027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1074252001028 Predicted membrane protein [Function unknown]; Region: COG3212 1074252001029 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1074252001030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1074252001031 non-specific DNA binding site [nucleotide binding]; other site 1074252001032 salt bridge; other site 1074252001033 sequence-specific DNA binding site [nucleotide binding]; other site 1074252001034 Predicted membrane protein [Function unknown]; Region: COG2261 1074252001035 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1074252001036 catalytic core [active] 1074252001037 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 1074252001038 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1074252001039 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1074252001040 catalytic residue [active] 1074252001041 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1074252001042 catalytic residues [active] 1074252001043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1074252001044 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252001045 peroxiredoxin; Region: AhpC; TIGR03137 1074252001046 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1074252001047 dimer interface [polypeptide binding]; other site 1074252001048 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1074252001049 catalytic triad [active] 1074252001050 peroxidatic and resolving cysteines [active] 1074252001051 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1074252001052 dimer interface [polypeptide binding]; other site 1074252001053 FMN binding site [chemical binding]; other site 1074252001054 NADPH bind site [chemical binding]; other site 1074252001055 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1074252001056 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1074252001057 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1074252001058 active site 1074252001059 xanthine permease; Region: pbuX; TIGR03173 1074252001060 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1074252001061 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1074252001062 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1074252001063 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1074252001064 active site 1074252001065 GMP synthase; Reviewed; Region: guaA; PRK00074 1074252001066 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1074252001067 AMP/PPi binding site [chemical binding]; other site 1074252001068 candidate oxyanion hole; other site 1074252001069 catalytic triad [active] 1074252001070 potential glutamine specificity residues [chemical binding]; other site 1074252001071 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1074252001072 ATP Binding subdomain [chemical binding]; other site 1074252001073 Ligand Binding sites [chemical binding]; other site 1074252001074 Dimerization subdomain; other site 1074252001075 Predicted membrane protein [Function unknown]; Region: COG3759 1074252001076 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1074252001077 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1074252001078 NADP binding site [chemical binding]; other site 1074252001079 superantigen-like protein; Reviewed; Region: PRK13037 1074252001080 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1074252001081 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252001082 superantigen-like protein; Reviewed; Region: PRK13041 1074252001083 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1074252001084 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252001085 superantigen-like protein; Reviewed; Region: PRK13335 1074252001086 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1074252001087 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252001088 superantigen-like protein 5; Reviewed; Region: PRK13035 1074252001089 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1074252001090 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252001091 superantigen-like protein 7; Reviewed; Region: PRK13346 1074252001092 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1074252001093 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252001094 superantigen-like protein; Reviewed; Region: PRK13345 1074252001095 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1074252001096 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252001097 superantigen-like protein; Reviewed; Region: PRK13038 1074252001098 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1074252001099 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252001100 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1074252001101 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1074252001102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252001103 S-adenosylmethionine binding site [chemical binding]; other site 1074252001104 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1074252001105 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1074252001106 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1074252001107 superantigen-like protein; Reviewed; Region: PRK13036 1074252001108 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1074252001109 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252001110 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252001111 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252001112 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252001113 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252001114 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252001115 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1074252001116 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1074252001117 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1074252001118 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1074252001119 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1074252001120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1074252001121 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1074252001122 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1074252001123 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1074252001124 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1074252001125 active site 1074252001126 Esterase/lipase [General function prediction only]; Region: COG1647 1074252001127 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1074252001128 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1074252001129 Na2 binding site [ion binding]; other site 1074252001130 putative substrate binding site 1 [chemical binding]; other site 1074252001131 Na binding site 1 [ion binding]; other site 1074252001132 putative substrate binding site 2 [chemical binding]; other site 1074252001133 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1074252001134 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1074252001135 dimer interface [polypeptide binding]; other site 1074252001136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252001137 catalytic residue [active] 1074252001138 cystathionine beta-lyase; Provisional; Region: PRK07671 1074252001139 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1074252001140 homodimer interface [polypeptide binding]; other site 1074252001141 substrate-cofactor binding pocket; other site 1074252001142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252001143 catalytic residue [active] 1074252001144 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1074252001145 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1074252001146 Walker A/P-loop; other site 1074252001147 ATP binding site [chemical binding]; other site 1074252001148 Q-loop/lid; other site 1074252001149 ABC transporter signature motif; other site 1074252001150 Walker B; other site 1074252001151 D-loop; other site 1074252001152 H-loop/switch region; other site 1074252001153 NIL domain; Region: NIL; pfam09383 1074252001154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252001155 dimer interface [polypeptide binding]; other site 1074252001156 conserved gate region; other site 1074252001157 ABC-ATPase subunit interface; other site 1074252001158 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1074252001159 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1074252001160 LysM domain; Region: LysM; pfam01476 1074252001161 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1074252001162 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1074252001163 Surface antigen [General function prediction only]; Region: COG3942 1074252001164 CHAP domain; Region: CHAP; pfam05257 1074252001165 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1074252001166 nudix motif; other site 1074252001167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252001168 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1074252001169 Coenzyme A binding pocket [chemical binding]; other site 1074252001170 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1074252001171 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1074252001172 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1074252001173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1074252001174 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1074252001175 dimerization interface [polypeptide binding]; other site 1074252001176 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1074252001177 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1074252001178 active site 1074252001179 dimer interface [polypeptide binding]; other site 1074252001180 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1074252001181 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1074252001182 active site 1074252001183 FMN binding site [chemical binding]; other site 1074252001184 substrate binding site [chemical binding]; other site 1074252001185 3Fe-4S cluster binding site [ion binding]; other site 1074252001186 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1074252001187 domain interface; other site 1074252001188 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1074252001189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1074252001190 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1074252001191 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1074252001192 active site turn [active] 1074252001193 phosphorylation site [posttranslational modification] 1074252001194 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1074252001195 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1074252001196 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1074252001197 Ca binding site [ion binding]; other site 1074252001198 active site 1074252001199 catalytic site [active] 1074252001200 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1074252001201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1074252001202 DNA-binding site [nucleotide binding]; DNA binding site 1074252001203 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1074252001204 UTRA domain; Region: UTRA; pfam07702 1074252001205 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1074252001206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252001207 Coenzyme A binding pocket [chemical binding]; other site 1074252001208 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1074252001209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252001210 Walker A motif; other site 1074252001211 ATP binding site [chemical binding]; other site 1074252001212 Walker B motif; other site 1074252001213 arginine finger; other site 1074252001214 hypothetical protein; Validated; Region: PRK00153 1074252001215 recombination protein RecR; Reviewed; Region: recR; PRK00076 1074252001216 RecR protein; Region: RecR; pfam02132 1074252001217 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1074252001218 putative active site [active] 1074252001219 putative metal-binding site [ion binding]; other site 1074252001220 tetramer interface [polypeptide binding]; other site 1074252001221 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1074252001222 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1074252001223 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1074252001224 catalytic residue [active] 1074252001225 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1074252001226 thymidylate kinase; Validated; Region: tmk; PRK00698 1074252001227 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1074252001228 TMP-binding site; other site 1074252001229 ATP-binding site [chemical binding]; other site 1074252001230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1074252001231 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1074252001232 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1074252001233 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1074252001234 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1074252001235 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1074252001236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252001237 S-adenosylmethionine binding site [chemical binding]; other site 1074252001238 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1074252001239 GIY-YIG motif/motif A; other site 1074252001240 putative active site [active] 1074252001241 putative metal binding site [ion binding]; other site 1074252001242 Predicted methyltransferases [General function prediction only]; Region: COG0313 1074252001243 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1074252001244 putative SAM binding site [chemical binding]; other site 1074252001245 putative homodimer interface [polypeptide binding]; other site 1074252001246 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1074252001247 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1074252001248 active site 1074252001249 HIGH motif; other site 1074252001250 KMSKS motif; other site 1074252001251 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1074252001252 tRNA binding surface [nucleotide binding]; other site 1074252001253 anticodon binding site; other site 1074252001254 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1074252001255 dimer interface [polypeptide binding]; other site 1074252001256 putative tRNA-binding site [nucleotide binding]; other site 1074252001257 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1074252001258 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1074252001259 active site 1074252001260 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1074252001261 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1074252001262 putative active site [active] 1074252001263 putative metal binding site [ion binding]; other site 1074252001264 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1074252001265 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1074252001266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252001267 S-adenosylmethionine binding site [chemical binding]; other site 1074252001268 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1074252001269 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1074252001270 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1074252001271 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1074252001272 pur operon repressor; Provisional; Region: PRK09213 1074252001273 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1074252001274 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1074252001275 active site 1074252001276 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1074252001277 homotrimer interaction site [polypeptide binding]; other site 1074252001278 putative active site [active] 1074252001279 regulatory protein SpoVG; Reviewed; Region: PRK13259 1074252001280 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1074252001281 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1074252001282 Substrate binding site; other site 1074252001283 Mg++ binding site; other site 1074252001284 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1074252001285 active site 1074252001286 substrate binding site [chemical binding]; other site 1074252001287 CoA binding site [chemical binding]; other site 1074252001288 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1074252001289 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1074252001290 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1074252001291 active site 1074252001292 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1074252001293 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1074252001294 5S rRNA interface [nucleotide binding]; other site 1074252001295 CTC domain interface [polypeptide binding]; other site 1074252001296 L16 interface [polypeptide binding]; other site 1074252001297 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1074252001298 putative active site [active] 1074252001299 catalytic residue [active] 1074252001300 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1074252001301 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1074252001302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252001303 ATP binding site [chemical binding]; other site 1074252001304 putative Mg++ binding site [ion binding]; other site 1074252001305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1074252001306 nucleotide binding region [chemical binding]; other site 1074252001307 ATP-binding site [chemical binding]; other site 1074252001308 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1074252001309 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1074252001310 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1074252001311 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1074252001312 putative SAM binding site [chemical binding]; other site 1074252001313 putative homodimer interface [polypeptide binding]; other site 1074252001314 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1074252001315 homodimer interface [polypeptide binding]; other site 1074252001316 metal binding site [ion binding]; metal-binding site 1074252001317 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1074252001318 RNA binding surface [nucleotide binding]; other site 1074252001319 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1074252001320 Septum formation initiator; Region: DivIC; pfam04977 1074252001321 hypothetical protein; Provisional; Region: PRK08582 1074252001322 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1074252001323 RNA binding site [nucleotide binding]; other site 1074252001324 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1074252001325 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1074252001326 Ligand Binding Site [chemical binding]; other site 1074252001327 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1074252001328 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1074252001329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1074252001330 active site 1074252001331 FtsH Extracellular; Region: FtsH_ext; pfam06480 1074252001332 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1074252001333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252001334 Walker A motif; other site 1074252001335 ATP binding site [chemical binding]; other site 1074252001336 Walker B motif; other site 1074252001337 arginine finger; other site 1074252001338 Peptidase family M41; Region: Peptidase_M41; pfam01434 1074252001339 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1074252001340 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1074252001341 dimerization interface [polypeptide binding]; other site 1074252001342 domain crossover interface; other site 1074252001343 redox-dependent activation switch; other site 1074252001344 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1074252001345 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1074252001346 dimer interface [polypeptide binding]; other site 1074252001347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252001348 catalytic residue [active] 1074252001349 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1074252001350 dihydropteroate synthase; Region: DHPS; TIGR01496 1074252001351 substrate binding pocket [chemical binding]; other site 1074252001352 dimer interface [polypeptide binding]; other site 1074252001353 inhibitor binding site; inhibition site 1074252001354 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1074252001355 homooctamer interface [polypeptide binding]; other site 1074252001356 active site 1074252001357 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1074252001358 catalytic center binding site [active] 1074252001359 ATP binding site [chemical binding]; other site 1074252001360 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1074252001361 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1074252001362 dimer interface [polypeptide binding]; other site 1074252001363 putative anticodon binding site; other site 1074252001364 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1074252001365 motif 1; other site 1074252001366 active site 1074252001367 motif 2; other site 1074252001368 motif 3; other site 1074252001369 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1074252001370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1074252001371 DNA-binding site [nucleotide binding]; DNA binding site 1074252001372 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1074252001373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252001374 homodimer interface [polypeptide binding]; other site 1074252001375 catalytic residue [active] 1074252001376 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1074252001377 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1074252001378 active site 1074252001379 multimer interface [polypeptide binding]; other site 1074252001380 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1074252001381 predicted active site [active] 1074252001382 catalytic triad [active] 1074252001383 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1074252001384 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1074252001385 Nucleoside recognition; Region: Gate; pfam07670 1074252001386 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1074252001387 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1074252001388 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1074252001389 UvrB/uvrC motif; Region: UVR; pfam02151 1074252001390 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1074252001391 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1074252001392 ADP binding site [chemical binding]; other site 1074252001393 phosphagen binding site; other site 1074252001394 substrate specificity loop; other site 1074252001395 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1074252001396 Clp amino terminal domain; Region: Clp_N; pfam02861 1074252001397 Clp amino terminal domain; Region: Clp_N; pfam02861 1074252001398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252001399 Walker A motif; other site 1074252001400 ATP binding site [chemical binding]; other site 1074252001401 Walker B motif; other site 1074252001402 arginine finger; other site 1074252001403 UvrB/uvrC motif; Region: UVR; pfam02151 1074252001404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252001405 Walker A motif; other site 1074252001406 ATP binding site [chemical binding]; other site 1074252001407 Walker B motif; other site 1074252001408 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1074252001409 DNA repair protein RadA; Provisional; Region: PRK11823 1074252001410 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1074252001411 Walker A motif/ATP binding site; other site 1074252001412 ATP binding site [chemical binding]; other site 1074252001413 Walker B motif; other site 1074252001414 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1074252001415 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1074252001416 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1074252001417 putative active site [active] 1074252001418 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1074252001419 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1074252001420 active site 1074252001421 HIGH motif; other site 1074252001422 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1074252001423 active site 1074252001424 KMSKS motif; other site 1074252001425 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1074252001426 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1074252001427 trimer interface [polypeptide binding]; other site 1074252001428 active site 1074252001429 substrate binding site [chemical binding]; other site 1074252001430 CoA binding site [chemical binding]; other site 1074252001431 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1074252001432 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1074252001433 active site 1074252001434 HIGH motif; other site 1074252001435 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1074252001436 KMSKS motif; other site 1074252001437 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1074252001438 tRNA binding surface [nucleotide binding]; other site 1074252001439 anticodon binding site; other site 1074252001440 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1074252001441 active site 1074252001442 dimerization interface [polypeptide binding]; other site 1074252001443 metal binding site [ion binding]; metal-binding site 1074252001444 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1074252001445 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1074252001446 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1074252001447 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1074252001448 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1074252001449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1074252001450 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1074252001451 DNA binding residues [nucleotide binding] 1074252001452 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1074252001453 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1074252001454 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1074252001455 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1074252001456 putative homodimer interface [polypeptide binding]; other site 1074252001457 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1074252001458 heterodimer interface [polypeptide binding]; other site 1074252001459 homodimer interface [polypeptide binding]; other site 1074252001460 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1074252001461 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1074252001462 23S rRNA interface [nucleotide binding]; other site 1074252001463 L7/L12 interface [polypeptide binding]; other site 1074252001464 putative thiostrepton binding site; other site 1074252001465 L25 interface [polypeptide binding]; other site 1074252001466 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1074252001467 mRNA/rRNA interface [nucleotide binding]; other site 1074252001468 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1074252001469 23S rRNA interface [nucleotide binding]; other site 1074252001470 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1074252001471 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1074252001472 peripheral dimer interface [polypeptide binding]; other site 1074252001473 core dimer interface [polypeptide binding]; other site 1074252001474 L10 interface [polypeptide binding]; other site 1074252001475 L11 interface [polypeptide binding]; other site 1074252001476 putative EF-Tu interaction site [polypeptide binding]; other site 1074252001477 putative EF-G interaction site [polypeptide binding]; other site 1074252001478 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1074252001479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252001480 S-adenosylmethionine binding site [chemical binding]; other site 1074252001481 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1074252001482 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1074252001483 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1074252001484 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1074252001485 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1074252001486 RPB10 interaction site [polypeptide binding]; other site 1074252001487 RPB1 interaction site [polypeptide binding]; other site 1074252001488 RPB11 interaction site [polypeptide binding]; other site 1074252001489 RPB3 interaction site [polypeptide binding]; other site 1074252001490 RPB12 interaction site [polypeptide binding]; other site 1074252001491 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1074252001492 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1074252001493 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1074252001494 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1074252001495 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1074252001496 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1074252001497 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1074252001498 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1074252001499 G-loop; other site 1074252001500 DNA binding site [nucleotide binding] 1074252001501 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 1074252001502 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1074252001503 S17 interaction site [polypeptide binding]; other site 1074252001504 S8 interaction site; other site 1074252001505 16S rRNA interaction site [nucleotide binding]; other site 1074252001506 streptomycin interaction site [chemical binding]; other site 1074252001507 23S rRNA interaction site [nucleotide binding]; other site 1074252001508 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1074252001509 30S ribosomal protein S7; Validated; Region: PRK05302 1074252001510 elongation factor G; Reviewed; Region: PRK00007 1074252001511 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1074252001512 G1 box; other site 1074252001513 putative GEF interaction site [polypeptide binding]; other site 1074252001514 GTP/Mg2+ binding site [chemical binding]; other site 1074252001515 Switch I region; other site 1074252001516 G2 box; other site 1074252001517 G3 box; other site 1074252001518 Switch II region; other site 1074252001519 G4 box; other site 1074252001520 G5 box; other site 1074252001521 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1074252001522 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1074252001523 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1074252001524 elongation factor Tu; Reviewed; Region: PRK00049 1074252001525 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1074252001526 G1 box; other site 1074252001527 GEF interaction site [polypeptide binding]; other site 1074252001528 GTP/Mg2+ binding site [chemical binding]; other site 1074252001529 Switch I region; other site 1074252001530 G2 box; other site 1074252001531 G3 box; other site 1074252001532 Switch II region; other site 1074252001533 G4 box; other site 1074252001534 G5 box; other site 1074252001535 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1074252001536 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1074252001537 Antibiotic Binding Site [chemical binding]; other site 1074252001538 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1074252001539 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1074252001540 metal binding site [ion binding]; metal-binding site 1074252001541 dimer interface [polypeptide binding]; other site 1074252001542 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1074252001543 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1074252001544 substrate-cofactor binding pocket; other site 1074252001545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252001546 catalytic residue [active] 1074252001547 chaperone protein HchA; Provisional; Region: PRK04155 1074252001548 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 1074252001549 dimer interface [polypeptide binding]; other site 1074252001550 metal binding site [ion binding]; metal-binding site 1074252001551 potential oxyanion hole; other site 1074252001552 potential catalytic triad [active] 1074252001553 conserved cys residue [active] 1074252001554 ribulokinase; Provisional; Region: PRK04123 1074252001555 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1074252001556 N- and C-terminal domain interface [polypeptide binding]; other site 1074252001557 active site 1074252001558 MgATP binding site [chemical binding]; other site 1074252001559 catalytic site [active] 1074252001560 metal binding site [ion binding]; metal-binding site 1074252001561 carbohydrate binding site [chemical binding]; other site 1074252001562 homodimer interface [polypeptide binding]; other site 1074252001563 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1074252001564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1074252001565 NAD(P) binding site [chemical binding]; other site 1074252001566 active site 1074252001567 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1074252001568 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1074252001569 homodimer interface [polypeptide binding]; other site 1074252001570 substrate-cofactor binding pocket; other site 1074252001571 catalytic residue [active] 1074252001572 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1074252001573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252001574 motif II; other site 1074252001575 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1074252001576 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1074252001577 Substrate-binding site [chemical binding]; other site 1074252001578 Substrate specificity [chemical binding]; other site 1074252001579 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1074252001580 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1074252001581 Substrate-binding site [chemical binding]; other site 1074252001582 Substrate specificity [chemical binding]; other site 1074252001583 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1074252001584 nucleoside/Zn binding site; other site 1074252001585 dimer interface [polypeptide binding]; other site 1074252001586 catalytic motif [active] 1074252001587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252001588 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1074252001589 active site 1074252001590 motif I; other site 1074252001591 motif II; other site 1074252001592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252001593 Predicted flavoprotein [General function prediction only]; Region: COG0431 1074252001594 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1074252001595 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1074252001596 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1074252001597 Cna protein B-type domain; Region: Cna_B; pfam05738 1074252001598 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1074252001599 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1074252001600 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1074252001601 Cna protein B-type domain; Region: Cna_B; pfam05738 1074252001602 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1074252001603 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1074252001604 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1074252001605 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1074252001606 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1074252001607 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1074252001608 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1074252001609 Cna protein B-type domain; Region: Cna_B; pfam05738 1074252001610 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1074252001611 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1074252001612 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1074252001613 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1074252001614 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1074252001615 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1074252001616 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1074252001617 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1074252001618 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1074252001619 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1074252001620 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1074252001621 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1074252001622 active site 1074252001623 trimer interface [polypeptide binding]; other site 1074252001624 allosteric site; other site 1074252001625 active site lid [active] 1074252001626 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1074252001627 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1074252001628 active site 1074252001629 dimer interface [polypeptide binding]; other site 1074252001630 magnesium binding site [ion binding]; other site 1074252001631 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1074252001632 tetramer interface [polypeptide binding]; other site 1074252001633 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1074252001634 active site 1074252001635 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1074252001636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252001637 motif II; other site 1074252001638 proline/glycine betaine transporter; Provisional; Region: PRK10642 1074252001639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252001640 putative substrate translocation pore; other site 1074252001641 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1074252001642 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1074252001643 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1074252001644 acyl-activating enzyme (AAE) consensus motif; other site 1074252001645 AMP binding site [chemical binding]; other site 1074252001646 active site 1074252001647 CoA binding site [chemical binding]; other site 1074252001648 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1074252001649 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1074252001650 dimer interface [polypeptide binding]; other site 1074252001651 active site 1074252001652 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1074252001653 dimer interface [polypeptide binding]; other site 1074252001654 substrate binding site [chemical binding]; other site 1074252001655 ATP binding site [chemical binding]; other site 1074252001656 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1074252001657 ligand binding site [chemical binding]; other site 1074252001658 active site 1074252001659 UGI interface [polypeptide binding]; other site 1074252001660 catalytic site [active] 1074252001661 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1074252001662 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1074252001663 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1074252001664 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1074252001665 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1074252001666 putative heme peroxidase; Provisional; Region: PRK12276 1074252001667 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1074252001668 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1074252001669 mevalonate kinase; Region: mevalon_kin; TIGR00549 1074252001670 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1074252001671 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1074252001672 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1074252001673 diphosphomevalonate decarboxylase; Region: PLN02407 1074252001674 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1074252001675 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1074252001676 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1074252001677 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1074252001678 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1074252001679 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1074252001680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252001681 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1074252001682 Predicted transcriptional regulator [Transcription]; Region: COG1959 1074252001683 Transcriptional regulator; Region: Rrf2; pfam02082 1074252001684 LXG domain of WXG superfamily; Region: LXG; pfam04740 1074252001685 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1074252001686 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1074252001687 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1074252001688 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1074252001689 active site 1074252001690 catalytic tetrad [active] 1074252001691 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1074252001692 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1074252001693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1074252001694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252001695 Coenzyme A binding pocket [chemical binding]; other site 1074252001696 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1074252001697 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1074252001698 Zn2+ binding site [ion binding]; other site 1074252001699 Mg2+ binding site [ion binding]; other site 1074252001700 YwhD family; Region: YwhD; pfam08741 1074252001701 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1074252001702 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1074252001703 NAD binding site [chemical binding]; other site 1074252001704 substrate binding site [chemical binding]; other site 1074252001705 catalytic Zn binding site [ion binding]; other site 1074252001706 tetramer interface [polypeptide binding]; other site 1074252001707 structural Zn binding site [ion binding]; other site 1074252001708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1074252001709 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1074252001710 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1074252001711 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1074252001712 active site 1074252001713 HIGH motif; other site 1074252001714 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1074252001715 KMSK motif region; other site 1074252001716 tRNA binding surface [nucleotide binding]; other site 1074252001717 DALR anticodon binding domain; Region: DALR_1; smart00836 1074252001718 anticodon binding site; other site 1074252001719 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1074252001720 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1074252001721 minor groove reading motif; other site 1074252001722 helix-hairpin-helix signature motif; other site 1074252001723 substrate binding pocket [chemical binding]; other site 1074252001724 active site 1074252001725 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1074252001726 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1074252001727 putative binding site residues; other site 1074252001728 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252001729 ABC-ATPase subunit interface; other site 1074252001730 dimer interface [polypeptide binding]; other site 1074252001731 putative PBP binding regions; other site 1074252001732 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1074252001733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252001734 motif II; other site 1074252001735 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1074252001736 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1074252001737 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1074252001738 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1074252001739 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252001740 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1074252001741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1074252001742 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1074252001743 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1074252001744 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1074252001745 active site 1074252001746 DNA binding site [nucleotide binding] 1074252001747 Int/Topo IB signature motif; other site 1074252001748 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 1074252001749 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1074252001750 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1074252001751 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 1074252001752 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1074252001753 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1074252001754 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1074252001755 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1074252001756 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1074252001757 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1074252001758 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1074252001759 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1074252001760 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1074252001761 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1074252001762 metal binding site [ion binding]; metal-binding site 1074252001763 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1074252001764 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252001765 ABC-ATPase subunit interface; other site 1074252001766 dimer interface [polypeptide binding]; other site 1074252001767 putative PBP binding regions; other site 1074252001768 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1074252001769 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1074252001770 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1074252001771 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1074252001772 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1074252001773 FeoA domain; Region: FeoA; pfam04023 1074252001774 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1074252001775 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1074252001776 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1074252001777 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1074252001778 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1074252001779 Walker A/P-loop; other site 1074252001780 ATP binding site [chemical binding]; other site 1074252001781 Q-loop/lid; other site 1074252001782 ABC transporter signature motif; other site 1074252001783 Walker B; other site 1074252001784 D-loop; other site 1074252001785 H-loop/switch region; other site 1074252001786 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1074252001787 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1074252001788 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1074252001789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1074252001790 active site 1074252001791 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1074252001792 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1074252001793 active site 1074252001794 nucleotide binding site [chemical binding]; other site 1074252001795 HIGH motif; other site 1074252001796 KMSKS motif; other site 1074252001797 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1074252001798 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1074252001799 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1074252001800 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1074252001801 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1074252001802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1074252001803 Walker A/P-loop; other site 1074252001804 ATP binding site [chemical binding]; other site 1074252001805 Q-loop/lid; other site 1074252001806 ABC transporter signature motif; other site 1074252001807 Walker B; other site 1074252001808 D-loop; other site 1074252001809 H-loop/switch region; other site 1074252001810 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1074252001811 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1074252001812 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1074252001813 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1074252001814 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1074252001815 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1074252001816 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1074252001817 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1074252001818 Walker A/P-loop; other site 1074252001819 ATP binding site [chemical binding]; other site 1074252001820 Q-loop/lid; other site 1074252001821 ABC transporter signature motif; other site 1074252001822 Walker B; other site 1074252001823 D-loop; other site 1074252001824 H-loop/switch region; other site 1074252001825 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1074252001826 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252001827 ABC-ATPase subunit interface; other site 1074252001828 dimer interface [polypeptide binding]; other site 1074252001829 putative PBP binding regions; other site 1074252001830 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1074252001831 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252001832 ABC-ATPase subunit interface; other site 1074252001833 dimer interface [polypeptide binding]; other site 1074252001834 putative PBP binding regions; other site 1074252001835 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1074252001836 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1074252001837 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1074252001838 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1074252001839 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1074252001840 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1074252001841 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1074252001842 Na binding site [ion binding]; other site 1074252001843 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1074252001844 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1074252001845 substrate binding pocket [chemical binding]; other site 1074252001846 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1074252001847 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1074252001848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252001849 Coenzyme A binding pocket [chemical binding]; other site 1074252001850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1074252001851 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1074252001852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1074252001853 NAD(P) binding site [chemical binding]; other site 1074252001854 active site 1074252001855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1074252001856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252001857 active site 1074252001858 phosphorylation site [posttranslational modification] 1074252001859 intermolecular recognition site; other site 1074252001860 dimerization interface [polypeptide binding]; other site 1074252001861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1074252001862 DNA binding site [nucleotide binding] 1074252001863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1074252001864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252001865 ATP binding site [chemical binding]; other site 1074252001866 Mg2+ binding site [ion binding]; other site 1074252001867 G-X-G motif; other site 1074252001868 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1074252001869 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1074252001870 Walker A/P-loop; other site 1074252001871 ATP binding site [chemical binding]; other site 1074252001872 Q-loop/lid; other site 1074252001873 ABC transporter signature motif; other site 1074252001874 Walker B; other site 1074252001875 D-loop; other site 1074252001876 H-loop/switch region; other site 1074252001877 FtsX-like permease family; Region: FtsX; pfam02687 1074252001878 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1074252001879 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1074252001880 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1074252001881 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1074252001882 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1074252001883 Surface antigen [General function prediction only]; Region: COG3942 1074252001884 CHAP domain; Region: CHAP; pfam05257 1074252001885 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1074252001886 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1074252001887 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1074252001888 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252001889 hypothetical protein; Provisional; Region: PRK12378 1074252001890 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1074252001891 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1074252001892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1074252001893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1074252001894 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1074252001895 dimerization interface [polypeptide binding]; other site 1074252001896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252001897 sugar efflux transporter; Region: 2A0120; TIGR00899 1074252001898 putative substrate translocation pore; other site 1074252001899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1074252001900 Serine incorporator (Serinc); Region: Serinc; pfam03348 1074252001901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252001902 Coenzyme A binding pocket [chemical binding]; other site 1074252001903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1074252001904 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1074252001905 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1074252001906 hypothetical protein; Validated; Region: PRK00124 1074252001907 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1074252001908 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1074252001909 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1074252001910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1074252001911 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1074252001912 Walker A/P-loop; other site 1074252001913 ATP binding site [chemical binding]; other site 1074252001914 Q-loop/lid; other site 1074252001915 ABC transporter signature motif; other site 1074252001916 Walker B; other site 1074252001917 D-loop; other site 1074252001918 H-loop/switch region; other site 1074252001919 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1074252001920 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1074252001921 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1074252001922 Walker A/P-loop; other site 1074252001923 ATP binding site [chemical binding]; other site 1074252001924 Q-loop/lid; other site 1074252001925 ABC transporter signature motif; other site 1074252001926 Walker B; other site 1074252001927 D-loop; other site 1074252001928 H-loop/switch region; other site 1074252001929 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1074252001930 MarR family; Region: MarR; pfam01047 1074252001931 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1074252001932 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1074252001933 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1074252001934 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1074252001935 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1074252001936 active site 1074252001937 catalytic tetrad [active] 1074252001938 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1074252001939 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1074252001940 transmembrane helices; other site 1074252001941 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1074252001942 DNA photolyase; Region: DNA_photolyase; pfam00875 1074252001943 Predicted membrane protein [Function unknown]; Region: COG4330 1074252001944 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1074252001945 trimer interface [polypeptide binding]; other site 1074252001946 putative Zn binding site [ion binding]; other site 1074252001947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252001948 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252001949 putative substrate translocation pore; other site 1074252001950 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1074252001951 putative deacylase active site [active] 1074252001952 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1074252001953 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1074252001954 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1074252001955 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1074252001956 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1074252001957 putative substrate binding site [chemical binding]; other site 1074252001958 putative ATP binding site [chemical binding]; other site 1074252001959 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1074252001960 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1074252001961 active site 1074252001962 phosphorylation site [posttranslational modification] 1074252001963 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1074252001964 active site 1074252001965 P-loop; other site 1074252001966 phosphorylation site [posttranslational modification] 1074252001967 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1074252001968 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1074252001969 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1074252001970 active site 1074252001971 dimer interface [polypeptide binding]; other site 1074252001972 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1074252001973 Domain of unknown function DUF21; Region: DUF21; pfam01595 1074252001974 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1074252001975 Transporter associated domain; Region: CorC_HlyC; pfam03471 1074252001976 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1074252001977 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1074252001978 active site 1074252001979 catalytic tetrad [active] 1074252001980 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1074252001981 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1074252001982 Ligand binding site; other site 1074252001983 Putative Catalytic site; other site 1074252001984 DXD motif; other site 1074252001985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1074252001986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1074252001987 dimer interface [polypeptide binding]; other site 1074252001988 phosphorylation site [posttranslational modification] 1074252001989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252001990 ATP binding site [chemical binding]; other site 1074252001991 Mg2+ binding site [ion binding]; other site 1074252001992 G-X-G motif; other site 1074252001993 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1074252001994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252001995 active site 1074252001996 phosphorylation site [posttranslational modification] 1074252001997 intermolecular recognition site; other site 1074252001998 dimerization interface [polypeptide binding]; other site 1074252001999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1074252002000 DNA binding site [nucleotide binding] 1074252002001 DoxX; Region: DoxX; cl17842 1074252002002 Electron transfer DM13; Region: DM13; pfam10517 1074252002003 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1074252002004 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1074252002005 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1074252002006 active site 1074252002007 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1074252002008 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1074252002009 Ligand Binding Site [chemical binding]; other site 1074252002010 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1074252002011 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1074252002012 glutamine binding [chemical binding]; other site 1074252002013 catalytic triad [active] 1074252002014 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1074252002015 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1074252002016 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1074252002017 substrate-cofactor binding pocket; other site 1074252002018 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1074252002019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252002020 catalytic residue [active] 1074252002021 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1074252002022 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1074252002023 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1074252002024 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1074252002025 Sulfatase; Region: Sulfatase; pfam00884 1074252002026 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1074252002027 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1074252002028 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1074252002029 ABC transporter; Region: ABC_tran_2; pfam12848 1074252002030 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1074252002031 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1074252002032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252002033 ATP binding site [chemical binding]; other site 1074252002034 putative Mg++ binding site [ion binding]; other site 1074252002035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1074252002036 nucleotide binding region [chemical binding]; other site 1074252002037 ATP-binding site [chemical binding]; other site 1074252002038 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1074252002039 HRDC domain; Region: HRDC; pfam00570 1074252002040 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1074252002041 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1074252002042 Walker A/P-loop; other site 1074252002043 ATP binding site [chemical binding]; other site 1074252002044 Q-loop/lid; other site 1074252002045 ABC transporter signature motif; other site 1074252002046 Walker B; other site 1074252002047 D-loop; other site 1074252002048 H-loop/switch region; other site 1074252002049 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1074252002050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252002051 dimer interface [polypeptide binding]; other site 1074252002052 conserved gate region; other site 1074252002053 ABC-ATPase subunit interface; other site 1074252002054 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1074252002055 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1074252002056 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1074252002057 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1074252002058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252002059 homodimer interface [polypeptide binding]; other site 1074252002060 catalytic residue [active] 1074252002061 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1074252002062 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1074252002063 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1074252002064 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1074252002065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252002066 putative substrate translocation pore; other site 1074252002067 POT family; Region: PTR2; cl17359 1074252002068 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1074252002069 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1074252002070 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1074252002071 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1074252002072 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1074252002073 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1074252002074 active site 1074252002075 dimer interface [polypeptide binding]; other site 1074252002076 catalytic residues [active] 1074252002077 effector binding site; other site 1074252002078 R2 peptide binding site; other site 1074252002079 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1074252002080 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1074252002081 dimer interface [polypeptide binding]; other site 1074252002082 putative radical transfer pathway; other site 1074252002083 diiron center [ion binding]; other site 1074252002084 tyrosyl radical; other site 1074252002085 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252002086 ABC-ATPase subunit interface; other site 1074252002087 dimer interface [polypeptide binding]; other site 1074252002088 putative PBP binding regions; other site 1074252002089 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252002090 ABC-ATPase subunit interface; other site 1074252002091 dimer interface [polypeptide binding]; other site 1074252002092 putative PBP binding regions; other site 1074252002093 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1074252002094 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1074252002095 Walker A/P-loop; other site 1074252002096 ATP binding site [chemical binding]; other site 1074252002097 Q-loop/lid; other site 1074252002098 ABC transporter signature motif; other site 1074252002099 Walker B; other site 1074252002100 D-loop; other site 1074252002101 H-loop/switch region; other site 1074252002102 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1074252002103 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1074252002104 putative ligand binding residues [chemical binding]; other site 1074252002105 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1074252002106 CHY zinc finger; Region: zf-CHY; pfam05495 1074252002107 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1074252002108 FAD binding domain; Region: FAD_binding_4; pfam01565 1074252002109 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1074252002110 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1074252002111 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1074252002112 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1074252002113 peptidase T; Region: peptidase-T; TIGR01882 1074252002114 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1074252002115 metal binding site [ion binding]; metal-binding site 1074252002116 dimer interface [polypeptide binding]; other site 1074252002117 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1074252002118 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1074252002119 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1074252002120 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1074252002121 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1074252002122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1074252002123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1074252002124 metal binding site [ion binding]; metal-binding site 1074252002125 active site 1074252002126 I-site; other site 1074252002127 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1074252002128 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1074252002129 Mg++ binding site [ion binding]; other site 1074252002130 putative catalytic motif [active] 1074252002131 substrate binding site [chemical binding]; other site 1074252002132 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1074252002133 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1074252002134 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1074252002135 EDD domain protein, DegV family; Region: DegV; TIGR00762 1074252002136 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1074252002137 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1074252002138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252002139 ATP binding site [chemical binding]; other site 1074252002140 putative Mg++ binding site [ion binding]; other site 1074252002141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1074252002142 nucleotide binding region [chemical binding]; other site 1074252002143 ATP-binding site [chemical binding]; other site 1074252002144 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1074252002145 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1074252002146 active site 1074252002147 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1074252002148 30S subunit binding site; other site 1074252002149 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1074252002150 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1074252002151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1074252002152 nucleotide binding region [chemical binding]; other site 1074252002153 ATP-binding site [chemical binding]; other site 1074252002154 SEC-C motif; Region: SEC-C; pfam02810 1074252002155 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1074252002156 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1074252002157 RF-1 domain; Region: RF-1; pfam00472 1074252002158 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1074252002159 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1074252002160 Surface antigen [General function prediction only]; Region: COG3942 1074252002161 CHAP domain; Region: CHAP; pfam05257 1074252002162 HD domain; Region: HD_3; cl17350 1074252002163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 1074252002164 excinuclease ABC subunit B; Provisional; Region: PRK05298 1074252002165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252002166 ATP binding site [chemical binding]; other site 1074252002167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1074252002168 nucleotide binding region [chemical binding]; other site 1074252002169 ATP-binding site [chemical binding]; other site 1074252002170 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1074252002171 UvrB/uvrC motif; Region: UVR; pfam02151 1074252002172 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1074252002173 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1074252002174 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1074252002175 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1074252002176 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1074252002177 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1074252002178 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1074252002179 Hpr binding site; other site 1074252002180 active site 1074252002181 homohexamer subunit interaction site [polypeptide binding]; other site 1074252002182 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1074252002183 putative acyl transferase; Provisional; Region: PRK10191 1074252002184 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1074252002185 trimer interface [polypeptide binding]; other site 1074252002186 active site 1074252002187 substrate binding site [chemical binding]; other site 1074252002188 CoA binding site [chemical binding]; other site 1074252002189 TPR repeat; Region: TPR_11; pfam13414 1074252002190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1074252002191 binding surface 1074252002192 TPR motif; other site 1074252002193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1074252002194 TPR motif; other site 1074252002195 binding surface 1074252002196 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1074252002197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1074252002198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252002199 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1074252002200 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1074252002201 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1074252002202 phosphate binding site [ion binding]; other site 1074252002203 dimer interface [polypeptide binding]; other site 1074252002204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1074252002205 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1074252002206 Clp protease; Region: CLP_protease; pfam00574 1074252002207 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1074252002208 oligomer interface [polypeptide binding]; other site 1074252002209 active site residues [active] 1074252002210 malate dehydrogenase; Provisional; Region: PRK13529 1074252002211 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1074252002212 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1074252002213 NAD(P) binding site [chemical binding]; other site 1074252002214 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1074252002215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1074252002216 NAD(P) binding site [chemical binding]; other site 1074252002217 active site 1074252002218 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1074252002219 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1074252002220 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1074252002221 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1074252002222 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1074252002223 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1074252002224 Phosphoglycerate kinase; Region: PGK; pfam00162 1074252002225 substrate binding site [chemical binding]; other site 1074252002226 hinge regions; other site 1074252002227 ADP binding site [chemical binding]; other site 1074252002228 catalytic site [active] 1074252002229 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1074252002230 triosephosphate isomerase; Provisional; Region: PRK14565 1074252002231 substrate binding site [chemical binding]; other site 1074252002232 dimer interface [polypeptide binding]; other site 1074252002233 catalytic triad [active] 1074252002234 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1074252002235 phosphoglyceromutase; Provisional; Region: PRK05434 1074252002236 enolase; Provisional; Region: eno; PRK00077 1074252002237 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1074252002238 dimer interface [polypeptide binding]; other site 1074252002239 metal binding site [ion binding]; metal-binding site 1074252002240 substrate binding pocket [chemical binding]; other site 1074252002241 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1074252002242 Esterase/lipase [General function prediction only]; Region: COG1647 1074252002243 ribonuclease R; Region: RNase_R; TIGR02063 1074252002244 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1074252002245 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1074252002246 RNB domain; Region: RNB; pfam00773 1074252002247 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1074252002248 RNA binding site [nucleotide binding]; other site 1074252002249 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1074252002250 SmpB-tmRNA interface; other site 1074252002252 transposase/IS protein; Provisional; Region: PRK09183 1074252002253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252002254 Walker A motif; other site 1074252002255 ATP binding site [chemical binding]; other site 1074252002256 Walker B motif; other site 1074252002257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1074252002258 Integrase core domain; Region: rve; pfam00665 1074252002259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252002260 Coenzyme A binding pocket [chemical binding]; other site 1074252002261 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1074252002262 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1074252002263 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1074252002264 Staphylococcal nuclease homologues; Region: SNc; smart00318 1074252002265 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1074252002266 Catalytic site; other site 1074252002267 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1074252002268 DNA-binding site [nucleotide binding]; DNA binding site 1074252002269 RNA-binding motif; other site 1074252002270 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1074252002271 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1074252002272 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1074252002273 catalytic core [active] 1074252002274 Lysine efflux permease [General function prediction only]; Region: COG1279 1074252002275 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1074252002276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1074252002277 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1074252002278 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1074252002279 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1074252002280 active site 1074252002281 catalytic residue [active] 1074252002282 dimer interface [polypeptide binding]; other site 1074252002283 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1074252002284 putative FMN binding site [chemical binding]; other site 1074252002285 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1074252002286 catalytic residues [active] 1074252002287 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1074252002288 ArsC family; Region: ArsC; pfam03960 1074252002289 putative ArsC-like catalytic residues; other site 1074252002290 putative TRX-like catalytic residues [active] 1074252002291 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1074252002292 lipoyl attachment site [posttranslational modification]; other site 1074252002293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1074252002294 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1074252002295 putative active site [active] 1074252002296 putative metal binding site [ion binding]; other site 1074252002297 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1074252002298 catalytic residues [active] 1074252002299 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1074252002300 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1074252002301 Walker A/P-loop; other site 1074252002302 ATP binding site [chemical binding]; other site 1074252002303 Q-loop/lid; other site 1074252002304 ABC transporter signature motif; other site 1074252002305 Walker B; other site 1074252002306 D-loop; other site 1074252002307 H-loop/switch region; other site 1074252002308 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1074252002309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252002310 dimer interface [polypeptide binding]; other site 1074252002311 conserved gate region; other site 1074252002312 ABC-ATPase subunit interface; other site 1074252002313 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1074252002314 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1074252002315 Predicted membrane protein [Function unknown]; Region: COG2035 1074252002316 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1074252002317 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1074252002318 Walker A/P-loop; other site 1074252002319 ATP binding site [chemical binding]; other site 1074252002320 Q-loop/lid; other site 1074252002321 ABC transporter signature motif; other site 1074252002322 Walker B; other site 1074252002323 D-loop; other site 1074252002324 H-loop/switch region; other site 1074252002325 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1074252002326 FeS assembly protein SufD; Region: sufD; TIGR01981 1074252002327 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1074252002328 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1074252002329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1074252002330 catalytic residue [active] 1074252002331 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1074252002332 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1074252002333 trimerization site [polypeptide binding]; other site 1074252002334 active site 1074252002335 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1074252002336 FeS assembly protein SufB; Region: sufB; TIGR01980 1074252002338 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1074252002339 Domain of unknown function DUF21; Region: DUF21; pfam01595 1074252002340 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1074252002341 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1074252002342 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1074252002343 FMN binding site [chemical binding]; other site 1074252002344 substrate binding site [chemical binding]; other site 1074252002345 putative catalytic residue [active] 1074252002346 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1074252002347 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1074252002348 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1074252002349 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1074252002350 active site 1074252002351 metal binding site [ion binding]; metal-binding site 1074252002352 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1074252002353 lipoyl synthase; Provisional; Region: PRK05481 1074252002354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1074252002355 FeS/SAM binding site; other site 1074252002356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1074252002357 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1074252002358 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1074252002359 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1074252002360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252002361 active site 1074252002362 motif I; other site 1074252002363 motif II; other site 1074252002364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252002365 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1074252002366 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1074252002367 dimerization interface [polypeptide binding]; other site 1074252002368 ligand binding site [chemical binding]; other site 1074252002369 NADP binding site [chemical binding]; other site 1074252002370 catalytic site [active] 1074252002371 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1074252002372 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1074252002373 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1074252002374 acyl-activating enzyme (AAE) consensus motif; other site 1074252002375 AMP binding site [chemical binding]; other site 1074252002376 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1074252002377 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1074252002378 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1074252002379 DltD N-terminal region; Region: DltD_N; pfam04915 1074252002380 DltD central region; Region: DltD_M; pfam04918 1074252002381 DltD C-terminal region; Region: DltD_C; pfam04914 1074252002382 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1074252002383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1074252002384 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1074252002385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252002386 hypothetical protein; Provisional; Region: PRK13669 1074252002387 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1074252002388 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1074252002389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252002390 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1074252002391 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1074252002392 interface (dimer of trimers) [polypeptide binding]; other site 1074252002393 Substrate-binding/catalytic site; other site 1074252002394 Zn-binding sites [ion binding]; other site 1074252002395 Predicted permease [General function prediction only]; Region: COG2056 1074252002396 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1074252002397 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1074252002398 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1074252002399 CoenzymeA binding site [chemical binding]; other site 1074252002400 subunit interaction site [polypeptide binding]; other site 1074252002401 PHB binding site; other site 1074252002402 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1074252002403 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1074252002404 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1074252002405 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1074252002406 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 1074252002407 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1074252002408 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1074252002409 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1074252002410 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1074252002411 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1074252002412 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1074252002413 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1074252002414 Kinase associated protein B; Region: KapB; pfam08810 1074252002415 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1074252002416 active site 1074252002417 general stress protein 13; Validated; Region: PRK08059 1074252002418 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1074252002419 RNA binding site [nucleotide binding]; other site 1074252002420 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1074252002421 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1074252002422 putative active site [active] 1074252002423 putative FMN binding site [chemical binding]; other site 1074252002424 putative substrate binding site [chemical binding]; other site 1074252002425 putative catalytic residue [active] 1074252002426 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1074252002427 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1074252002428 inhibitor-cofactor binding pocket; inhibition site 1074252002429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252002430 catalytic residue [active] 1074252002431 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1074252002432 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1074252002433 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1074252002434 NAD(P) binding site [chemical binding]; other site 1074252002435 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1074252002436 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1074252002437 active site 1074252002438 catalytic site [active] 1074252002439 metal binding site [ion binding]; metal-binding site 1074252002440 argininosuccinate lyase; Provisional; Region: PRK00855 1074252002441 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1074252002442 active sites [active] 1074252002443 tetramer interface [polypeptide binding]; other site 1074252002444 argininosuccinate synthase; Provisional; Region: PRK13820 1074252002445 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1074252002446 ANP binding site [chemical binding]; other site 1074252002447 Substrate Binding Site II [chemical binding]; other site 1074252002448 Substrate Binding Site I [chemical binding]; other site 1074252002449 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1074252002450 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1074252002451 active site 1074252002452 dimer interface [polypeptide binding]; other site 1074252002453 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1074252002454 dimer interface [polypeptide binding]; other site 1074252002455 active site 1074252002456 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1074252002457 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1074252002458 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1074252002459 Catalytic site [active] 1074252002460 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1074252002461 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1074252002462 Catalytic site [active] 1074252002463 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1074252002464 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1074252002465 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1074252002466 Part of AAA domain; Region: AAA_19; pfam13245 1074252002467 Family description; Region: UvrD_C_2; pfam13538 1074252002468 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1074252002469 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1074252002470 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1074252002471 hypothetical protein; Provisional; Region: PRK13673 1074252002472 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1074252002473 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1074252002474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252002475 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1074252002476 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1074252002477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252002478 active site 1074252002479 motif I; other site 1074252002480 motif II; other site 1074252002481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252002482 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1074252002483 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1074252002484 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1074252002485 catalytic triad [active] 1074252002486 catalytic triad [active] 1074252002487 oxyanion hole [active] 1074252002488 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1074252002489 Clp amino terminal domain; Region: Clp_N; pfam02861 1074252002490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252002491 Walker A motif; other site 1074252002492 ATP binding site [chemical binding]; other site 1074252002493 Walker B motif; other site 1074252002494 arginine finger; other site 1074252002495 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1074252002496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252002497 Walker A motif; other site 1074252002498 ATP binding site [chemical binding]; other site 1074252002499 Walker B motif; other site 1074252002500 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1074252002501 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1074252002502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1074252002503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1074252002504 dimerization interface [polypeptide binding]; other site 1074252002505 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1074252002506 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1074252002507 active site 1074252002508 catalytic residues [active] 1074252002509 metal binding site [ion binding]; metal-binding site 1074252002510 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1074252002511 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1074252002512 substrate binding site [chemical binding]; other site 1074252002513 MAP domain; Region: MAP; pfam03642 1074252002514 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1074252002515 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1074252002516 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1074252002517 dimer interface [polypeptide binding]; other site 1074252002518 active site 1074252002519 CoA binding pocket [chemical binding]; other site 1074252002520 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1074252002521 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1074252002522 dimer interface [polypeptide binding]; other site 1074252002523 active site 1074252002524 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1074252002525 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1074252002526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252002527 dimer interface [polypeptide binding]; other site 1074252002528 conserved gate region; other site 1074252002529 putative PBP binding loops; other site 1074252002530 ABC-ATPase subunit interface; other site 1074252002531 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1074252002532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252002533 dimer interface [polypeptide binding]; other site 1074252002534 conserved gate region; other site 1074252002535 putative PBP binding loops; other site 1074252002536 ABC-ATPase subunit interface; other site 1074252002537 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1074252002538 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1074252002539 Walker A/P-loop; other site 1074252002540 ATP binding site [chemical binding]; other site 1074252002541 Q-loop/lid; other site 1074252002542 ABC transporter signature motif; other site 1074252002543 Walker B; other site 1074252002544 D-loop; other site 1074252002545 H-loop/switch region; other site 1074252002546 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1074252002548 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1074252002549 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1074252002550 peptide binding site [polypeptide binding]; other site 1074252002551 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1074252002552 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1074252002553 peptide binding site [polypeptide binding]; other site 1074252002554 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1074252002555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1074252002556 Walker A/P-loop; other site 1074252002557 ATP binding site [chemical binding]; other site 1074252002558 Q-loop/lid; other site 1074252002559 ABC transporter signature motif; other site 1074252002560 Walker B; other site 1074252002561 D-loop; other site 1074252002562 H-loop/switch region; other site 1074252002563 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1074252002564 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1074252002565 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1074252002566 Walker A/P-loop; other site 1074252002567 ATP binding site [chemical binding]; other site 1074252002568 Q-loop/lid; other site 1074252002569 ABC transporter signature motif; other site 1074252002570 Walker B; other site 1074252002571 D-loop; other site 1074252002572 H-loop/switch region; other site 1074252002573 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1074252002575 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1074252002576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252002577 dimer interface [polypeptide binding]; other site 1074252002578 conserved gate region; other site 1074252002579 putative PBP binding loops; other site 1074252002580 ABC-ATPase subunit interface; other site 1074252002582 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1074252002583 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1074252002584 active site 1074252002585 HIGH motif; other site 1074252002586 dimer interface [polypeptide binding]; other site 1074252002587 KMSKS motif; other site 1074252002588 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1074252002589 ArsC family; Region: ArsC; pfam03960 1074252002590 putative catalytic residues [active] 1074252002591 thiol/disulfide switch; other site 1074252002592 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1074252002593 adaptor protein; Provisional; Region: PRK02315 1074252002594 Competence protein CoiA-like family; Region: CoiA; cl11541 1074252002595 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1074252002596 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1074252002597 active site 1074252002598 Zn binding site [ion binding]; other site 1074252002599 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1074252002600 Thioredoxin; Region: Thioredoxin_5; pfam13743 1074252002601 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1074252002602 apolar tunnel; other site 1074252002603 heme binding site [chemical binding]; other site 1074252002604 dimerization interface [polypeptide binding]; other site 1074252002605 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1074252002606 putative active site [active] 1074252002607 putative metal binding residues [ion binding]; other site 1074252002608 signature motif; other site 1074252002609 putative triphosphate binding site [ion binding]; other site 1074252002610 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1074252002611 synthetase active site [active] 1074252002612 NTP binding site [chemical binding]; other site 1074252002613 metal binding site [ion binding]; metal-binding site 1074252002614 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1074252002615 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1074252002616 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1074252002617 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1074252002618 active site 1074252002619 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1074252002620 MgtE intracellular N domain; Region: MgtE_N; smart00924 1074252002621 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1074252002622 Divalent cation transporter; Region: MgtE; pfam01769 1074252002623 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1074252002624 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1074252002625 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1074252002626 TrkA-N domain; Region: TrkA_N; pfam02254 1074252002627 TrkA-C domain; Region: TrkA_C; pfam02080 1074252002628 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1074252002629 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1074252002630 NAD binding site [chemical binding]; other site 1074252002631 homotetramer interface [polypeptide binding]; other site 1074252002632 homodimer interface [polypeptide binding]; other site 1074252002633 substrate binding site [chemical binding]; other site 1074252002634 active site 1074252002635 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1074252002636 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1074252002637 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1074252002638 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1074252002639 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1074252002640 Putative esterase; Region: Esterase; pfam00756 1074252002641 hypothetical protein; Provisional; Region: PRK13679 1074252002642 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1074252002643 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252002644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252002645 putative substrate translocation pore; other site 1074252002646 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1074252002647 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1074252002648 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1074252002649 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1074252002650 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1074252002651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1074252002652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1074252002653 YueH-like protein; Region: YueH; pfam14166 1074252002654 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1074252002655 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1074252002656 G1 box; other site 1074252002657 putative GEF interaction site [polypeptide binding]; other site 1074252002658 GTP/Mg2+ binding site [chemical binding]; other site 1074252002659 Switch I region; other site 1074252002660 G2 box; other site 1074252002661 G3 box; other site 1074252002662 Switch II region; other site 1074252002663 G4 box; other site 1074252002664 G5 box; other site 1074252002665 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1074252002666 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1074252002667 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1074252002668 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1074252002669 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1074252002670 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1074252002671 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1074252002672 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1074252002673 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1074252002674 active site 1074252002675 metal binding site [ion binding]; metal-binding site 1074252002676 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1074252002677 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1074252002678 IDEAL domain; Region: IDEAL; pfam08858 1074252002679 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1074252002680 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1074252002681 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1074252002682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1074252002683 CAAX protease self-immunity; Region: Abi; pfam02517 1074252002685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1074252002686 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1074252002687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1074252002689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1074252002690 Integrase core domain; Region: rve; pfam00665 1074252002691 transposase/IS protein; Provisional; Region: PRK09183 1074252002692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252002693 Walker A motif; other site 1074252002694 ATP binding site [chemical binding]; other site 1074252002695 Walker B motif; other site 1074252002696 Predicted membrane protein [Function unknown]; Region: COG2259 1074252002698 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1074252002699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252002700 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1074252002701 Coenzyme A binding pocket [chemical binding]; other site 1074252002702 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1074252002703 UbiA prenyltransferase family; Region: UbiA; pfam01040 1074252002704 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1074252002705 isochorismate synthases; Region: isochor_syn; TIGR00543 1074252002706 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1074252002707 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1074252002708 dimer interface [polypeptide binding]; other site 1074252002709 tetramer interface [polypeptide binding]; other site 1074252002710 PYR/PP interface [polypeptide binding]; other site 1074252002711 TPP binding site [chemical binding]; other site 1074252002712 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1074252002713 TPP-binding site; other site 1074252002714 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1074252002715 PGAP1-like protein; Region: PGAP1; pfam07819 1074252002716 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1074252002717 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1074252002718 substrate binding site [chemical binding]; other site 1074252002719 oxyanion hole (OAH) forming residues; other site 1074252002720 trimer interface [polypeptide binding]; other site 1074252002721 Staphostatin B; Region: Staphostatin_B; pfam09023 1074252002722 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1074252002723 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1074252002724 aminotransferase A; Validated; Region: PRK07683 1074252002725 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1074252002726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252002727 homodimer interface [polypeptide binding]; other site 1074252002728 catalytic residue [active] 1074252002729 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1074252002730 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1074252002731 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1074252002732 MarR family; Region: MarR; pfam01047 1074252002733 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1074252002734 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1074252002735 amidase catalytic site [active] 1074252002736 Zn binding residues [ion binding]; other site 1074252002737 substrate binding site [chemical binding]; other site 1074252002738 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1074252002739 Lysozyme subfamily 2; Region: LYZ2; smart00047 1074252002740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252002741 Coenzyme A binding pocket [chemical binding]; other site 1074252002742 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1074252002743 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1074252002744 Beta-lactamase; Region: Beta-lactamase; pfam00144 1074252002745 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1074252002746 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1074252002747 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1074252002748 Subunit I/III interface [polypeptide binding]; other site 1074252002749 Subunit III/IV interface [polypeptide binding]; other site 1074252002750 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1074252002751 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1074252002752 D-pathway; other site 1074252002753 Putative ubiquinol binding site [chemical binding]; other site 1074252002754 Low-spin heme (heme b) binding site [chemical binding]; other site 1074252002755 Putative water exit pathway; other site 1074252002756 Binuclear center (heme o3/CuB) [ion binding]; other site 1074252002757 K-pathway; other site 1074252002758 Putative proton exit pathway; other site 1074252002759 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1074252002760 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1074252002761 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1074252002762 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1074252002763 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1074252002764 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1074252002765 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1074252002766 homodimer interface [polypeptide binding]; other site 1074252002767 NADP binding site [chemical binding]; other site 1074252002768 substrate binding site [chemical binding]; other site 1074252002769 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1074252002770 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1074252002771 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1074252002772 NAD binding site [chemical binding]; other site 1074252002773 ATP-grasp domain; Region: ATP-grasp; pfam02222 1074252002774 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1074252002775 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1074252002776 ATP binding site [chemical binding]; other site 1074252002777 active site 1074252002778 substrate binding site [chemical binding]; other site 1074252002779 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1074252002780 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1074252002781 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1074252002782 putative active site [active] 1074252002783 catalytic triad [active] 1074252002784 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1074252002785 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1074252002786 dimerization interface [polypeptide binding]; other site 1074252002787 ATP binding site [chemical binding]; other site 1074252002788 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1074252002789 dimerization interface [polypeptide binding]; other site 1074252002790 ATP binding site [chemical binding]; other site 1074252002791 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1074252002792 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1074252002793 active site 1074252002794 tetramer interface [polypeptide binding]; other site 1074252002795 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1074252002796 active site 1074252002797 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1074252002798 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1074252002799 dimerization interface [polypeptide binding]; other site 1074252002800 putative ATP binding site [chemical binding]; other site 1074252002801 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1074252002802 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1074252002803 active site 1074252002804 substrate binding site [chemical binding]; other site 1074252002805 cosubstrate binding site; other site 1074252002806 catalytic site [active] 1074252002807 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1074252002808 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1074252002809 purine monophosphate binding site [chemical binding]; other site 1074252002810 dimer interface [polypeptide binding]; other site 1074252002811 putative catalytic residues [active] 1074252002812 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1074252002813 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1074252002814 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1074252002815 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1074252002816 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1074252002817 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1074252002818 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1074252002819 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1074252002820 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1074252002821 Walker A/P-loop; other site 1074252002822 ATP binding site [chemical binding]; other site 1074252002823 Q-loop/lid; other site 1074252002824 ABC transporter signature motif; other site 1074252002825 Walker B; other site 1074252002826 D-loop; other site 1074252002827 H-loop/switch region; other site 1074252002828 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1074252002829 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1074252002830 Walker A/P-loop; other site 1074252002831 ATP binding site [chemical binding]; other site 1074252002832 Q-loop/lid; other site 1074252002833 ABC transporter signature motif; other site 1074252002834 Walker B; other site 1074252002835 D-loop; other site 1074252002836 H-loop/switch region; other site 1074252002837 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1074252002838 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1074252002839 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1074252002840 putative RNA binding site [nucleotide binding]; other site 1074252002841 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1074252002842 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1074252002843 dimerization domain swap beta strand [polypeptide binding]; other site 1074252002844 regulatory protein interface [polypeptide binding]; other site 1074252002845 active site 1074252002846 regulatory phosphorylation site [posttranslational modification]; other site 1074252002847 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1074252002848 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1074252002849 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1074252002850 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1074252002851 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1074252002852 catalytic residues [active] 1074252002853 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1074252002854 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1074252002855 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1074252002856 TrkA-N domain; Region: TrkA_N; pfam02254 1074252002857 TrkA-C domain; Region: TrkA_C; pfam02080 1074252002858 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1074252002859 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1074252002860 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1074252002861 hypothetical protein; Provisional; Region: PRK13667 1074252002862 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1074252002863 active site 1074252002864 catalytic residues [active] 1074252002865 metal binding site [ion binding]; metal-binding site 1074252002866 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1074252002867 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1074252002868 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1074252002869 TPP-binding site [chemical binding]; other site 1074252002870 tetramer interface [polypeptide binding]; other site 1074252002871 heterodimer interface [polypeptide binding]; other site 1074252002872 phosphorylation loop region [posttranslational modification] 1074252002873 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1074252002874 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1074252002875 alpha subunit interface [polypeptide binding]; other site 1074252002876 TPP binding site [chemical binding]; other site 1074252002877 heterodimer interface [polypeptide binding]; other site 1074252002878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1074252002879 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1074252002880 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1074252002881 E3 interaction surface; other site 1074252002882 lipoyl attachment site [posttranslational modification]; other site 1074252002883 e3 binding domain; Region: E3_binding; pfam02817 1074252002884 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1074252002885 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1074252002886 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1074252002887 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252002888 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1074252002889 hypothetical protein; Provisional; Region: PRK04387 1074252002890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1074252002891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1074252002892 non-specific DNA binding site [nucleotide binding]; other site 1074252002893 salt bridge; other site 1074252002894 sequence-specific DNA binding site [nucleotide binding]; other site 1074252002895 Cupin domain; Region: Cupin_2; pfam07883 1074252002896 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1074252002897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1074252002898 Walker A/P-loop; other site 1074252002899 ATP binding site [chemical binding]; other site 1074252002900 Q-loop/lid; other site 1074252002901 ABC transporter signature motif; other site 1074252002902 Walker B; other site 1074252002903 D-loop; other site 1074252002904 H-loop/switch region; other site 1074252002905 TOBE domain; Region: TOBE_2; pfam08402 1074252002906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252002907 dimer interface [polypeptide binding]; other site 1074252002908 conserved gate region; other site 1074252002909 putative PBP binding loops; other site 1074252002910 ABC-ATPase subunit interface; other site 1074252002911 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1074252002912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252002913 dimer interface [polypeptide binding]; other site 1074252002914 conserved gate region; other site 1074252002915 putative PBP binding loops; other site 1074252002916 ABC-ATPase subunit interface; other site 1074252002917 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1074252002918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1074252002919 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1074252002920 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1074252002921 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1074252002922 manganese transport protein MntH; Reviewed; Region: PRK00701 1074252002923 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1074252002924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1074252002925 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1074252002926 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1074252002927 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1074252002928 active site 1074252002929 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1074252002930 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1074252002931 G1 box; other site 1074252002932 putative GEF interaction site [polypeptide binding]; other site 1074252002933 GTP/Mg2+ binding site [chemical binding]; other site 1074252002934 Switch I region; other site 1074252002935 G2 box; other site 1074252002936 G3 box; other site 1074252002937 Switch II region; other site 1074252002938 G4 box; other site 1074252002939 G5 box; other site 1074252002940 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1074252002941 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1074252002942 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1074252002943 hypothetical protein; Provisional; Region: PRK13666 1074252002944 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1074252002945 pyruvate carboxylase; Reviewed; Region: PRK12999 1074252002946 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1074252002947 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1074252002948 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1074252002949 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1074252002950 active site 1074252002951 catalytic residues [active] 1074252002952 metal binding site [ion binding]; metal-binding site 1074252002953 homodimer binding site [polypeptide binding]; other site 1074252002954 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1074252002955 carboxyltransferase (CT) interaction site; other site 1074252002956 biotinylation site [posttranslational modification]; other site 1074252002957 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1074252002958 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1074252002959 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1074252002960 UbiA prenyltransferase family; Region: UbiA; pfam01040 1074252002961 Predicted membrane protein [Function unknown]; Region: COG2322 1074252002962 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1074252002963 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1074252002964 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1074252002965 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1074252002966 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1074252002967 putative active site [active] 1074252002968 catalytic site [active] 1074252002969 putative metal binding site [ion binding]; other site 1074252002970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 1074252002971 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1074252002972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252002973 S-adenosylmethionine binding site [chemical binding]; other site 1074252002974 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1074252002975 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1074252002976 active site 1074252002977 (T/H)XGH motif; other site 1074252002978 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1074252002979 hypothetical protein; Provisional; Region: PRK13670 1074252002980 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1074252002981 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1074252002983 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1074252002984 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1074252002985 heme-binding site [chemical binding]; other site 1074252002986 heme uptake protein IsdC; Region: IsdC; TIGR03656 1074252002987 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1074252002988 heme-binding site [chemical binding]; other site 1074252002989 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 1074252002990 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1074252002991 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1074252002992 intersubunit interface [polypeptide binding]; other site 1074252002993 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1074252002994 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252002995 ABC-ATPase subunit interface; other site 1074252002996 dimer interface [polypeptide binding]; other site 1074252002997 putative PBP binding regions; other site 1074252002998 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1074252002999 active site 1074252003000 catalytic site [active] 1074252003001 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 1074252003002 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1074252003003 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1074252003004 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1074252003005 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1074252003006 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1074252003007 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1074252003008 dimer interface [polypeptide binding]; other site 1074252003009 motif 1; other site 1074252003010 active site 1074252003011 motif 2; other site 1074252003012 motif 3; other site 1074252003013 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1074252003014 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1074252003015 putative tRNA-binding site [nucleotide binding]; other site 1074252003016 B3/4 domain; Region: B3_4; pfam03483 1074252003017 tRNA synthetase B5 domain; Region: B5; smart00874 1074252003018 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1074252003019 dimer interface [polypeptide binding]; other site 1074252003020 motif 1; other site 1074252003021 motif 3; other site 1074252003022 motif 2; other site 1074252003023 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1074252003024 ribonuclease HIII; Provisional; Region: PRK00996 1074252003025 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1074252003026 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1074252003027 RNA/DNA hybrid binding site [nucleotide binding]; other site 1074252003028 active site 1074252003029 Cell division protein ZapA; Region: ZapA; cl01146 1074252003030 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1074252003031 Colicin V production protein; Region: Colicin_V; pfam02674 1074252003032 hypothetical protein; Provisional; Region: PRK08609 1074252003033 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1074252003034 active site 1074252003035 primer binding site [nucleotide binding]; other site 1074252003036 NTP binding site [chemical binding]; other site 1074252003037 metal binding triad [ion binding]; metal-binding site 1074252003038 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1074252003039 active site 1074252003040 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1074252003041 MutS domain III; Region: MutS_III; pfam05192 1074252003042 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1074252003043 Walker A/P-loop; other site 1074252003044 ATP binding site [chemical binding]; other site 1074252003045 Q-loop/lid; other site 1074252003046 ABC transporter signature motif; other site 1074252003047 Walker B; other site 1074252003048 D-loop; other site 1074252003049 H-loop/switch region; other site 1074252003050 Smr domain; Region: Smr; pfam01713 1074252003051 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1074252003052 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1074252003053 catalytic residues [active] 1074252003054 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1074252003055 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1074252003056 GIY-YIG motif/motif A; other site 1074252003057 active site 1074252003058 catalytic site [active] 1074252003059 putative DNA binding site [nucleotide binding]; other site 1074252003060 metal binding site [ion binding]; metal-binding site 1074252003061 UvrB/uvrC motif; Region: UVR; pfam02151 1074252003062 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1074252003063 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1074252003064 putative Iron-sulfur protein interface [polypeptide binding]; other site 1074252003065 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1074252003066 proximal heme binding site [chemical binding]; other site 1074252003067 distal heme binding site [chemical binding]; other site 1074252003068 putative dimer interface [polypeptide binding]; other site 1074252003069 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1074252003070 L-aspartate oxidase; Provisional; Region: PRK06175 1074252003071 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1074252003072 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1074252003073 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1074252003074 glutamate racemase; Provisional; Region: PRK00865 1074252003075 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1074252003076 active site 1074252003077 dimerization interface [polypeptide binding]; other site 1074252003078 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1074252003079 active site 1074252003080 metal binding site [ion binding]; metal-binding site 1074252003081 homotetramer interface [polypeptide binding]; other site 1074252003082 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1074252003083 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 1074252003085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1074252003086 Integrase core domain; Region: rve; pfam00665 1074252003087 transposase/IS protein; Provisional; Region: PRK09183 1074252003088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252003089 Walker A motif; other site 1074252003090 ATP binding site [chemical binding]; other site 1074252003091 Walker B motif; other site 1074252003092 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1074252003093 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1074252003094 superantigen-like protein; Reviewed; Region: PRK13350 1074252003095 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252003096 superantigen-like protein; Reviewed; Region: PRK13349 1074252003097 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252003098 superantigen-like protein; Reviewed; Region: PRK13043 1074252003099 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252003100 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1074252003101 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1074252003102 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1074252003103 carbamate kinase; Reviewed; Region: PRK12686 1074252003104 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1074252003105 putative substrate binding site [chemical binding]; other site 1074252003106 nucleotide binding site [chemical binding]; other site 1074252003107 nucleotide binding site [chemical binding]; other site 1074252003108 homodimer interface [polypeptide binding]; other site 1074252003109 Predicted membrane protein [Function unknown]; Region: COG1288 1074252003110 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1074252003111 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1074252003112 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1074252003113 gating phenylalanine in ion channel; other site 1074252003114 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1074252003115 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1074252003116 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1074252003117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252003118 motif II; other site 1074252003119 hypothetical protein; Provisional; Region: PRK13688 1074252003120 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1074252003121 Coenzyme A binding pocket [chemical binding]; other site 1074252003122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1074252003123 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1074252003124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1074252003125 MraZ protein; Region: MraZ; pfam02381 1074252003126 MraZ protein; Region: MraZ; pfam02381 1074252003127 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1074252003128 MraW methylase family; Region: Methyltransf_5; pfam01795 1074252003129 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1074252003130 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1074252003131 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1074252003132 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1074252003133 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1074252003134 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1074252003135 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1074252003136 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1074252003137 Mg++ binding site [ion binding]; other site 1074252003138 putative catalytic motif [active] 1074252003139 putative substrate binding site [chemical binding]; other site 1074252003140 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1074252003141 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1074252003142 NAD binding site [chemical binding]; other site 1074252003143 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1074252003144 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1074252003145 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1074252003146 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1074252003147 Cell division protein FtsQ; Region: FtsQ; pfam03799 1074252003148 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1074252003149 Cell division protein FtsA; Region: FtsA; smart00842 1074252003150 Cell division protein FtsA; Region: FtsA; pfam14450 1074252003151 cell division protein FtsZ; Validated; Region: PRK09330 1074252003152 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1074252003153 nucleotide binding site [chemical binding]; other site 1074252003154 SulA interaction site; other site 1074252003155 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1074252003156 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1074252003157 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1074252003158 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1074252003159 catalytic residue [active] 1074252003160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1074252003161 YGGT family; Region: YGGT; pfam02325 1074252003162 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1074252003163 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1074252003164 RNA binding surface [nucleotide binding]; other site 1074252003165 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1074252003166 DivIVA domain; Region: DivI1A_domain; TIGR03544 1074252003167 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1074252003168 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1074252003169 HIGH motif; other site 1074252003170 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1074252003171 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1074252003172 active site 1074252003173 KMSKS motif; other site 1074252003174 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1074252003175 tRNA binding surface [nucleotide binding]; other site 1074252003176 anticodon binding site; other site 1074252003177 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1074252003180 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1074252003181 lipoprotein signal peptidase; Provisional; Region: PRK14787 1074252003182 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1074252003183 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1074252003184 RNA binding surface [nucleotide binding]; other site 1074252003185 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1074252003186 active site 1074252003187 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1074252003188 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1074252003189 uracil transporter; Provisional; Region: PRK10720 1074252003190 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1074252003191 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1074252003192 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1074252003193 dihydroorotase; Validated; Region: pyrC; PRK09357 1074252003194 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1074252003195 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1074252003196 active site 1074252003197 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1074252003198 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1074252003199 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1074252003200 catalytic site [active] 1074252003201 subunit interface [polypeptide binding]; other site 1074252003202 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1074252003203 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1074252003204 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1074252003205 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1074252003206 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1074252003207 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1074252003208 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1074252003209 IMP binding site; other site 1074252003210 dimer interface [polypeptide binding]; other site 1074252003211 interdomain contacts; other site 1074252003212 partial ornithine binding site; other site 1074252003213 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1074252003214 active site 1074252003215 dimer interface [polypeptide binding]; other site 1074252003216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1074252003217 active site 1074252003218 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1074252003219 dimer interface [polypeptide binding]; other site 1074252003220 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1074252003221 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1074252003222 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1074252003223 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1074252003224 catalytic site [active] 1074252003225 G-X2-G-X-G-K; other site 1074252003226 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1074252003227 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1074252003228 Flavoprotein; Region: Flavoprotein; pfam02441 1074252003229 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1074252003230 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1074252003231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252003232 ATP binding site [chemical binding]; other site 1074252003233 putative Mg++ binding site [ion binding]; other site 1074252003234 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1074252003235 nucleotide binding region [chemical binding]; other site 1074252003236 ATP-binding site [chemical binding]; other site 1074252003237 TM2 domain; Region: TM2; pfam05154 1074252003238 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1074252003239 active site 1074252003240 catalytic residues [active] 1074252003241 metal binding site [ion binding]; metal-binding site 1074252003242 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1074252003243 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1074252003244 putative active site [active] 1074252003245 substrate binding site [chemical binding]; other site 1074252003246 putative cosubstrate binding site; other site 1074252003247 catalytic site [active] 1074252003248 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1074252003249 substrate binding site [chemical binding]; other site 1074252003250 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1074252003251 NusB family; Region: NusB; pfam01029 1074252003252 putative RNA binding site [nucleotide binding]; other site 1074252003253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252003254 S-adenosylmethionine binding site [chemical binding]; other site 1074252003255 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1074252003256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1074252003257 FeS/SAM binding site; other site 1074252003258 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1074252003259 Protein phosphatase 2C; Region: PP2C; pfam00481 1074252003260 active site 1074252003261 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1074252003262 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1074252003263 active site 1074252003264 ATP binding site [chemical binding]; other site 1074252003265 substrate binding site [chemical binding]; other site 1074252003266 activation loop (A-loop); other site 1074252003267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1074252003268 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1074252003269 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1074252003270 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1074252003271 Predicted GTPases [General function prediction only]; Region: COG1162 1074252003272 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1074252003273 RNA binding site [nucleotide binding]; other site 1074252003274 homodimer interface [polypeptide binding]; other site 1074252003275 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1074252003276 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1074252003277 GTP/Mg2+ binding site [chemical binding]; other site 1074252003278 G4 box; other site 1074252003279 G5 box; other site 1074252003280 G1 box; other site 1074252003281 Switch I region; other site 1074252003282 G2 box; other site 1074252003283 G3 box; other site 1074252003284 Switch II region; other site 1074252003285 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1074252003286 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1074252003287 substrate binding site [chemical binding]; other site 1074252003288 hexamer interface [polypeptide binding]; other site 1074252003289 metal binding site [ion binding]; metal-binding site 1074252003290 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1074252003291 Thiamine pyrophosphokinase; Region: TPK; cd07995 1074252003292 active site 1074252003293 dimerization interface [polypeptide binding]; other site 1074252003294 thiamine binding site [chemical binding]; other site 1074252003295 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1074252003296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1074252003297 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1074252003298 DAK2 domain; Region: Dak2; pfam02734 1074252003299 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1074252003300 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1074252003301 generic binding surface II; other site 1074252003302 ssDNA binding site; other site 1074252003303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252003304 ATP binding site [chemical binding]; other site 1074252003305 putative Mg++ binding site [ion binding]; other site 1074252003306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1074252003307 nucleotide binding region [chemical binding]; other site 1074252003308 ATP-binding site [chemical binding]; other site 1074252003309 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1074252003310 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1074252003311 active site 2 [active] 1074252003312 active site 1 [active] 1074252003313 putative phosphate acyltransferase; Provisional; Region: PRK05331 1074252003314 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1074252003315 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1074252003316 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1074252003317 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1074252003318 NAD(P) binding site [chemical binding]; other site 1074252003319 homotetramer interface [polypeptide binding]; other site 1074252003320 homodimer interface [polypeptide binding]; other site 1074252003321 active site 1074252003322 acyl carrier protein; Provisional; Region: acpP; PRK00982 1074252003323 ribonuclease III; Reviewed; Region: rnc; PRK00102 1074252003324 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1074252003325 dimerization interface [polypeptide binding]; other site 1074252003326 active site 1074252003327 metal binding site [ion binding]; metal-binding site 1074252003328 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1074252003329 dsRNA binding site [nucleotide binding]; other site 1074252003330 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1074252003331 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1074252003332 Walker A/P-loop; other site 1074252003333 ATP binding site [chemical binding]; other site 1074252003334 Q-loop/lid; other site 1074252003335 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1074252003336 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1074252003337 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1074252003338 ABC transporter signature motif; other site 1074252003339 Walker B; other site 1074252003340 D-loop; other site 1074252003341 H-loop/switch region; other site 1074252003342 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1074252003343 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1074252003344 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1074252003345 P loop; other site 1074252003346 GTP binding site [chemical binding]; other site 1074252003347 putative DNA-binding protein; Validated; Region: PRK00118 1074252003348 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1074252003349 signal recognition particle protein; Provisional; Region: PRK10867 1074252003350 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1074252003351 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1074252003352 P loop; other site 1074252003353 GTP binding site [chemical binding]; other site 1074252003354 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1074252003355 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1074252003356 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1074252003357 RimM N-terminal domain; Region: RimM; pfam01782 1074252003358 PRC-barrel domain; Region: PRC; pfam05239 1074252003359 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1074252003360 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1074252003361 Predicted membrane protein [Function unknown]; Region: COG4485 1074252003362 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1074252003363 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1074252003364 GTP/Mg2+ binding site [chemical binding]; other site 1074252003365 G4 box; other site 1074252003366 G5 box; other site 1074252003367 G1 box; other site 1074252003368 Switch I region; other site 1074252003369 G2 box; other site 1074252003370 G3 box; other site 1074252003371 Switch II region; other site 1074252003372 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1074252003373 RNA/DNA hybrid binding site [nucleotide binding]; other site 1074252003374 active site 1074252003375 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1074252003376 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1074252003377 CoA-ligase; Region: Ligase_CoA; pfam00549 1074252003378 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1074252003379 CoA binding domain; Region: CoA_binding; pfam02629 1074252003380 CoA-ligase; Region: Ligase_CoA; pfam00549 1074252003381 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1074252003382 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1074252003383 CHAP domain; Region: CHAP; pfam05257 1074252003384 FemAB family; Region: FemAB; pfam02388 1074252003385 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1074252003386 DNA protecting protein DprA; Region: dprA; TIGR00732 1074252003387 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1074252003388 DNA topoisomerase I; Validated; Region: PRK05582 1074252003389 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1074252003390 active site 1074252003391 interdomain interaction site; other site 1074252003392 putative metal-binding site [ion binding]; other site 1074252003393 nucleotide binding site [chemical binding]; other site 1074252003394 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1074252003395 domain I; other site 1074252003396 DNA binding groove [nucleotide binding] 1074252003397 phosphate binding site [ion binding]; other site 1074252003398 domain II; other site 1074252003399 domain III; other site 1074252003400 nucleotide binding site [chemical binding]; other site 1074252003401 catalytic site [active] 1074252003402 domain IV; other site 1074252003403 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1074252003404 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1074252003405 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1074252003406 Glucose inhibited division protein A; Region: GIDA; pfam01134 1074252003407 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1074252003408 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1074252003409 active site 1074252003410 DNA binding site [nucleotide binding] 1074252003411 Int/Topo IB signature motif; other site 1074252003412 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1074252003413 active site 1074252003414 HslU subunit interaction site [polypeptide binding]; other site 1074252003415 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1074252003416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252003417 Walker A motif; other site 1074252003418 ATP binding site [chemical binding]; other site 1074252003419 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1074252003420 Walker B motif; other site 1074252003421 arginine finger; other site 1074252003422 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1074252003423 transcriptional repressor CodY; Validated; Region: PRK04158 1074252003424 CodY GAF-like domain; Region: CodY; pfam06018 1074252003425 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1074252003426 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1074252003427 rRNA interaction site [nucleotide binding]; other site 1074252003428 S8 interaction site; other site 1074252003429 putative laminin-1 binding site; other site 1074252003430 elongation factor Ts; Provisional; Region: tsf; PRK09377 1074252003431 UBA/TS-N domain; Region: UBA; pfam00627 1074252003432 Elongation factor TS; Region: EF_TS; pfam00889 1074252003433 Elongation factor TS; Region: EF_TS; pfam00889 1074252003434 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1074252003435 putative nucleotide binding site [chemical binding]; other site 1074252003436 uridine monophosphate binding site [chemical binding]; other site 1074252003437 homohexameric interface [polypeptide binding]; other site 1074252003438 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1074252003439 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1074252003440 hinge region; other site 1074252003441 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1074252003442 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1074252003443 catalytic residue [active] 1074252003444 putative FPP diphosphate binding site; other site 1074252003445 putative FPP binding hydrophobic cleft; other site 1074252003446 dimer interface [polypeptide binding]; other site 1074252003447 putative IPP diphosphate binding site; other site 1074252003448 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1074252003449 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1074252003450 RIP metalloprotease RseP; Region: TIGR00054 1074252003451 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1074252003452 active site 1074252003453 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1074252003454 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1074252003455 protein binding site [polypeptide binding]; other site 1074252003456 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1074252003457 putative substrate binding region [chemical binding]; other site 1074252003458 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1074252003459 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1074252003460 dimer interface [polypeptide binding]; other site 1074252003461 motif 1; other site 1074252003462 active site 1074252003463 motif 2; other site 1074252003464 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1074252003465 putative deacylase active site [active] 1074252003466 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1074252003467 active site 1074252003468 motif 3; other site 1074252003469 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1074252003470 anticodon binding site; other site 1074252003471 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1074252003472 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1074252003473 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1074252003474 generic binding surface II; other site 1074252003475 generic binding surface I; other site 1074252003476 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1074252003477 active site 1074252003478 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1074252003479 active site 1074252003480 catalytic site [active] 1074252003481 substrate binding site [chemical binding]; other site 1074252003482 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1074252003483 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1074252003484 Sm and related proteins; Region: Sm_like; cl00259 1074252003485 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1074252003486 putative oligomer interface [polypeptide binding]; other site 1074252003487 putative RNA binding site [nucleotide binding]; other site 1074252003488 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1074252003489 NusA N-terminal domain; Region: NusA_N; pfam08529 1074252003490 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1074252003491 RNA binding site [nucleotide binding]; other site 1074252003492 homodimer interface [polypeptide binding]; other site 1074252003493 NusA-like KH domain; Region: KH_5; pfam13184 1074252003494 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1074252003495 G-X-X-G motif; other site 1074252003496 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1074252003497 putative RNA binding cleft [nucleotide binding]; other site 1074252003498 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1074252003499 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1074252003500 translation initiation factor IF-2; Region: IF-2; TIGR00487 1074252003501 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1074252003502 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1074252003503 G1 box; other site 1074252003504 putative GEF interaction site [polypeptide binding]; other site 1074252003505 GTP/Mg2+ binding site [chemical binding]; other site 1074252003506 Switch I region; other site 1074252003507 G2 box; other site 1074252003508 G3 box; other site 1074252003509 Switch II region; other site 1074252003510 G4 box; other site 1074252003511 G5 box; other site 1074252003512 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1074252003513 Translation-initiation factor 2; Region: IF-2; pfam11987 1074252003514 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1074252003515 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1074252003516 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1074252003517 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1074252003518 RNA binding site [nucleotide binding]; other site 1074252003519 active site 1074252003520 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1074252003521 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1074252003522 active site 1074252003523 Riboflavin kinase; Region: Flavokinase; smart00904 1074252003524 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1074252003525 16S/18S rRNA binding site [nucleotide binding]; other site 1074252003526 S13e-L30e interaction site [polypeptide binding]; other site 1074252003527 25S rRNA binding site [nucleotide binding]; other site 1074252003528 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1074252003529 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1074252003530 RNase E interface [polypeptide binding]; other site 1074252003531 trimer interface [polypeptide binding]; other site 1074252003532 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1074252003533 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1074252003534 RNase E interface [polypeptide binding]; other site 1074252003535 trimer interface [polypeptide binding]; other site 1074252003536 active site 1074252003537 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1074252003538 putative nucleic acid binding region [nucleotide binding]; other site 1074252003539 G-X-X-G motif; other site 1074252003540 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1074252003541 RNA binding site [nucleotide binding]; other site 1074252003542 domain interface; other site 1074252003543 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1074252003544 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1074252003545 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1074252003546 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1074252003547 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1074252003548 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1074252003549 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1074252003550 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1074252003551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1074252003552 DNA-binding site [nucleotide binding]; DNA binding site 1074252003553 UTRA domain; Region: UTRA; pfam07702 1074252003554 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1074252003555 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1074252003556 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1074252003557 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1074252003558 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1074252003559 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1074252003560 classical (c) SDRs; Region: SDR_c; cd05233 1074252003561 NAD(P) binding site [chemical binding]; other site 1074252003562 active site 1074252003563 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1074252003564 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1074252003565 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1074252003566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1074252003567 non-specific DNA binding site [nucleotide binding]; other site 1074252003568 salt bridge; other site 1074252003569 sequence-specific DNA binding site [nucleotide binding]; other site 1074252003570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1074252003571 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1074252003572 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1074252003573 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1074252003574 putative MPT binding site; other site 1074252003575 recombinase A; Provisional; Region: recA; PRK09354 1074252003576 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1074252003577 hexamer interface [polypeptide binding]; other site 1074252003578 Walker A motif; other site 1074252003579 ATP binding site [chemical binding]; other site 1074252003580 Walker B motif; other site 1074252003581 phosphodiesterase; Provisional; Region: PRK12704 1074252003582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1074252003583 Zn2+ binding site [ion binding]; other site 1074252003584 Mg2+ binding site [ion binding]; other site 1074252003586 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1074252003587 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1074252003588 putative active site [active] 1074252003589 metal binding site [ion binding]; metal-binding site 1074252003590 homodimer binding site [polypeptide binding]; other site 1074252003591 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1074252003592 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1074252003593 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1074252003594 dimer interface [polypeptide binding]; other site 1074252003595 PYR/PP interface [polypeptide binding]; other site 1074252003596 TPP binding site [chemical binding]; other site 1074252003597 substrate binding site [chemical binding]; other site 1074252003598 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1074252003599 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1074252003600 TPP-binding site [chemical binding]; other site 1074252003601 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1074252003602 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1074252003603 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1074252003604 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1074252003605 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1074252003606 FeS/SAM binding site; other site 1074252003607 TRAM domain; Region: TRAM; pfam01938 1074252003608 Predicted membrane protein [Function unknown]; Region: COG4550 1074252003609 Predicted membrane protein [Function unknown]; Region: COG4732 1074252003610 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1074252003611 MutS domain I; Region: MutS_I; pfam01624 1074252003612 MutS domain II; Region: MutS_II; pfam05188 1074252003613 MutS domain III; Region: MutS_III; pfam05192 1074252003614 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1074252003615 Walker A/P-loop; other site 1074252003616 ATP binding site [chemical binding]; other site 1074252003617 Q-loop/lid; other site 1074252003618 ABC transporter signature motif; other site 1074252003619 Walker B; other site 1074252003620 D-loop; other site 1074252003621 H-loop/switch region; other site 1074252003622 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1074252003623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252003624 ATP binding site [chemical binding]; other site 1074252003625 Mg2+ binding site [ion binding]; other site 1074252003626 G-X-G motif; other site 1074252003627 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1074252003628 ATP binding site [chemical binding]; other site 1074252003629 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1074252003630 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 1074252003631 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1074252003632 amphipathic channel; other site 1074252003633 Asn-Pro-Ala signature motifs; other site 1074252003634 glycerol kinase; Provisional; Region: glpK; PRK00047 1074252003635 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1074252003636 N- and C-terminal domain interface [polypeptide binding]; other site 1074252003637 active site 1074252003638 MgATP binding site [chemical binding]; other site 1074252003639 catalytic site [active] 1074252003640 metal binding site [ion binding]; metal-binding site 1074252003641 glycerol binding site [chemical binding]; other site 1074252003642 homotetramer interface [polypeptide binding]; other site 1074252003643 homodimer interface [polypeptide binding]; other site 1074252003644 FBP binding site [chemical binding]; other site 1074252003645 protein IIAGlc interface [polypeptide binding]; other site 1074252003646 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1074252003647 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1074252003648 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1074252003649 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 1074252003650 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1074252003651 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1074252003652 bacterial Hfq-like; Region: Hfq; cd01716 1074252003653 hexamer interface [polypeptide binding]; other site 1074252003654 Sm1 motif; other site 1074252003655 RNA binding site [nucleotide binding]; other site 1074252003656 Sm2 motif; other site 1074252003657 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1074252003658 catalytic residues [active] 1074252003659 dimer interface [polypeptide binding]; other site 1074252003660 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1074252003661 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1074252003662 HflX GTPase family; Region: HflX; cd01878 1074252003663 G1 box; other site 1074252003664 GTP/Mg2+ binding site [chemical binding]; other site 1074252003665 Switch I region; other site 1074252003666 G2 box; other site 1074252003667 G3 box; other site 1074252003668 Switch II region; other site 1074252003669 G4 box; other site 1074252003670 G5 box; other site 1074252003671 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1074252003672 Aluminium resistance protein; Region: Alum_res; pfam06838 1074252003673 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1074252003674 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1074252003675 DNA binding residues [nucleotide binding] 1074252003676 putative dimer interface [polypeptide binding]; other site 1074252003677 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1074252003678 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1074252003679 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1074252003680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1074252003682 transposase/IS protein; Provisional; Region: PRK09183 1074252003683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252003684 Walker A motif; other site 1074252003685 ATP binding site [chemical binding]; other site 1074252003686 Walker B motif; other site 1074252003687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1074252003688 Integrase core domain; Region: rve; pfam00665 1074252003689 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1074252003690 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1074252003691 putative active site [active] 1074252003692 putative NTP binding site [chemical binding]; other site 1074252003693 putative nucleic acid binding site [nucleotide binding]; other site 1074252003694 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1074252003697 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1074252003698 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1074252003699 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1074252003700 catalytic residue [active] 1074252003701 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1074252003702 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1074252003703 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1074252003704 putative active site [active] 1074252003705 catalytic site [active] 1074252003706 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1074252003707 putative active site [active] 1074252003708 catalytic site [active] 1074252003709 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1074252003710 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1074252003711 Walker A/P-loop; other site 1074252003712 ATP binding site [chemical binding]; other site 1074252003713 Q-loop/lid; other site 1074252003714 ABC transporter signature motif; other site 1074252003715 Walker B; other site 1074252003716 D-loop; other site 1074252003717 H-loop/switch region; other site 1074252003718 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1074252003719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1074252003720 Histidine kinase; Region: HisKA_3; pfam07730 1074252003721 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1074252003722 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1074252003723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252003724 active site 1074252003725 phosphorylation site [posttranslational modification] 1074252003726 intermolecular recognition site; other site 1074252003727 dimerization interface [polypeptide binding]; other site 1074252003728 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1074252003729 DNA binding residues [nucleotide binding] 1074252003730 dimerization interface [polypeptide binding]; other site 1074252003731 Staphylococcal nuclease homologues; Region: SNc; smart00318 1074252003732 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1074252003733 Catalytic site; other site 1074252003734 AAA domain; Region: AAA_11; pfam13086 1074252003735 aspartate kinase; Reviewed; Region: PRK09034 1074252003736 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1074252003737 putative catalytic residues [active] 1074252003738 putative nucleotide binding site [chemical binding]; other site 1074252003739 putative aspartate binding site [chemical binding]; other site 1074252003740 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1074252003741 allosteric regulatory residue; other site 1074252003742 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1074252003743 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1074252003744 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1074252003745 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1074252003746 threonine synthase; Reviewed; Region: PRK06721 1074252003747 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1074252003748 homodimer interface [polypeptide binding]; other site 1074252003749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252003750 catalytic residue [active] 1074252003751 homoserine kinase; Provisional; Region: PRK01212 1074252003752 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1074252003753 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1074252003754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252003755 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1074252003756 active site 1074252003757 motif I; other site 1074252003758 motif II; other site 1074252003759 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1074252003760 lysine transporter; Provisional; Region: PRK10836 1074252003761 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1074252003762 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1074252003763 tetramer interface [polypeptide binding]; other site 1074252003764 heme binding pocket [chemical binding]; other site 1074252003765 NADPH binding site [chemical binding]; other site 1074252003766 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1074252003767 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1074252003768 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1074252003769 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1074252003770 active site 1074252003771 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1074252003772 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1074252003773 LexA repressor; Validated; Region: PRK00215 1074252003774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1074252003775 putative DNA binding site [nucleotide binding]; other site 1074252003776 putative Zn2+ binding site [ion binding]; other site 1074252003777 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1074252003778 Catalytic site [active] 1074252003779 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1074252003780 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1074252003781 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1074252003782 TPP-binding site [chemical binding]; other site 1074252003783 dimer interface [polypeptide binding]; other site 1074252003784 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1074252003785 PYR/PP interface [polypeptide binding]; other site 1074252003786 dimer interface [polypeptide binding]; other site 1074252003787 TPP binding site [chemical binding]; other site 1074252003788 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1074252003789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1074252003790 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1074252003791 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1074252003792 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1074252003793 active site 1074252003794 metal binding site [ion binding]; metal-binding site 1074252003795 DNA binding site [nucleotide binding] 1074252003796 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1074252003797 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1074252003798 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1074252003799 Walker A/P-loop; other site 1074252003800 ATP binding site [chemical binding]; other site 1074252003801 Q-loop/lid; other site 1074252003802 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1074252003803 ABC transporter signature motif; other site 1074252003804 Walker B; other site 1074252003805 D-loop; other site 1074252003806 H-loop/switch region; other site 1074252003807 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1074252003808 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1074252003809 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1074252003810 aconitate hydratase; Validated; Region: PRK09277 1074252003811 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1074252003812 substrate binding site [chemical binding]; other site 1074252003813 ligand binding site [chemical binding]; other site 1074252003814 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1074252003815 substrate binding site [chemical binding]; other site 1074252003816 Transposase; Region: HTH_Tnp_1; cl17663 1074252003817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1074252003818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1074252003819 Helix-turn-helix domain; Region: HTH_28; pfam13518 1074252003820 HTH-like domain; Region: HTH_21; pfam13276 1074252003821 Integrase core domain; Region: rve; pfam00665 1074252003822 Integrase core domain; Region: rve_2; pfam13333 1074252003823 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1074252003824 active site 1074252003825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1074252003826 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1074252003827 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1074252003828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252003829 ATP binding site [chemical binding]; other site 1074252003830 Mg2+ binding site [ion binding]; other site 1074252003831 G-X-G motif; other site 1074252003832 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1074252003833 anchoring element; other site 1074252003834 dimer interface [polypeptide binding]; other site 1074252003835 ATP binding site [chemical binding]; other site 1074252003836 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1074252003837 active site 1074252003838 putative metal-binding site [ion binding]; other site 1074252003839 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1074252003840 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1074252003841 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1074252003842 CAP-like domain; other site 1074252003843 active site 1074252003844 primary dimer interface [polypeptide binding]; other site 1074252003845 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1074252003846 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1074252003847 amino acid carrier protein; Region: agcS; TIGR00835 1074252003848 CAT RNA binding domain; Region: CAT_RBD; smart01061 1074252003849 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1074252003850 PRD domain; Region: PRD; pfam00874 1074252003851 PRD domain; Region: PRD; pfam00874 1074252003852 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1074252003853 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1074252003854 Predicted integral membrane protein [Function unknown]; Region: COG0392 1074252003855 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1074252003856 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1074252003857 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1074252003858 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1074252003859 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1074252003860 active site 1 [active] 1074252003861 dimer interface [polypeptide binding]; other site 1074252003862 hexamer interface [polypeptide binding]; other site 1074252003863 active site 2 [active] 1074252003864 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1074252003865 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1074252003866 active site 1074252003867 DNA binding site [nucleotide binding] 1074252003868 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1074252003869 prephenate dehydrogenase; Validated; Region: PRK06545 1074252003870 prephenate dehydrogenase; Validated; Region: PRK08507 1074252003871 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1074252003872 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1074252003873 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1074252003874 putative oligomer interface [polypeptide binding]; other site 1074252003875 putative active site [active] 1074252003876 metal binding site [ion binding]; metal-binding site 1074252003877 anthranilate synthase component I; Provisional; Region: PRK13567 1074252003878 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1074252003879 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1074252003880 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1074252003881 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1074252003882 glutamine binding [chemical binding]; other site 1074252003883 catalytic triad [active] 1074252003884 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1074252003885 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1074252003886 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1074252003887 active site 1074252003888 ribulose/triose binding site [chemical binding]; other site 1074252003889 phosphate binding site [ion binding]; other site 1074252003890 substrate (anthranilate) binding pocket [chemical binding]; other site 1074252003891 product (indole) binding pocket [chemical binding]; other site 1074252003892 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1074252003893 active site 1074252003894 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1074252003895 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1074252003896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252003897 catalytic residue [active] 1074252003898 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1074252003899 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1074252003900 substrate binding site [chemical binding]; other site 1074252003901 active site 1074252003902 catalytic residues [active] 1074252003903 heterodimer interface [polypeptide binding]; other site 1074252003904 FemAB family; Region: FemAB; pfam02388 1074252003905 FlxA-like protein; Region: FlxA; pfam14282 1074252003906 FemAB family; Region: FemAB; pfam02388 1074252003908 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1074252003909 Replication initiation factor; Region: Rep_trans; pfam02486 1074252003910 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1074252003911 TcpE family; Region: TcpE; pfam12648 1074252003912 AAA-like domain; Region: AAA_10; pfam12846 1074252003913 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1074252003914 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1074252003915 ribonuclease E; Reviewed; Region: rne; PRK10811 1074252003916 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1074252003917 Surface antigen [General function prediction only]; Region: COG3942 1074252003918 CHAP domain; Region: CHAP; pfam05257 1074252003919 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1074252003921 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1074252003922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252003923 active site 1074252003924 motif I; other site 1074252003925 motif II; other site 1074252003926 SWIM zinc finger; Region: SWIM; pfam04434 1074252003927 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1074252003928 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1074252003929 Walker A/P-loop; other site 1074252003930 ATP binding site [chemical binding]; other site 1074252003931 Q-loop/lid; other site 1074252003932 ABC transporter signature motif; other site 1074252003933 Walker B; other site 1074252003934 D-loop; other site 1074252003935 H-loop/switch region; other site 1074252003936 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1074252003937 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1074252003938 Walker A/P-loop; other site 1074252003939 ATP binding site [chemical binding]; other site 1074252003940 Q-loop/lid; other site 1074252003941 ABC transporter signature motif; other site 1074252003942 Walker B; other site 1074252003943 D-loop; other site 1074252003944 H-loop/switch region; other site 1074252003945 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1074252003946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252003947 dimer interface [polypeptide binding]; other site 1074252003948 conserved gate region; other site 1074252003949 putative PBP binding loops; other site 1074252003950 ABC-ATPase subunit interface; other site 1074252003951 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1074252003952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252003953 dimer interface [polypeptide binding]; other site 1074252003954 conserved gate region; other site 1074252003955 putative PBP binding loops; other site 1074252003956 ABC-ATPase subunit interface; other site 1074252003957 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1074252003958 oligoendopeptidase F; Region: pepF; TIGR00181 1074252003959 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1074252003960 active site 1074252003961 Zn binding site [ion binding]; other site 1074252003962 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1074252003963 PhoU domain; Region: PhoU; pfam01895 1074252003964 PhoU domain; Region: PhoU; pfam01895 1074252003965 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1074252003966 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1074252003967 Walker A/P-loop; other site 1074252003968 ATP binding site [chemical binding]; other site 1074252003969 Q-loop/lid; other site 1074252003970 ABC transporter signature motif; other site 1074252003971 Walker B; other site 1074252003972 D-loop; other site 1074252003973 H-loop/switch region; other site 1074252003974 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1074252003975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252003976 dimer interface [polypeptide binding]; other site 1074252003977 conserved gate region; other site 1074252003978 putative PBP binding loops; other site 1074252003979 ABC-ATPase subunit interface; other site 1074252003980 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1074252003981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252003982 dimer interface [polypeptide binding]; other site 1074252003983 conserved gate region; other site 1074252003984 ABC-ATPase subunit interface; other site 1074252003985 phosphate binding protein; Region: ptsS_2; TIGR02136 1074252003986 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1074252003987 S1 domain; Region: S1_2; pfam13509 1074252003988 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1074252003989 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1074252003990 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1074252003991 ABC transporter; Region: ABC_tran_2; pfam12848 1074252003992 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1074252003993 aspartate kinase; Reviewed; Region: PRK06635 1074252003994 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1074252003995 putative nucleotide binding site [chemical binding]; other site 1074252003996 putative catalytic residues [active] 1074252003997 putative Mg ion binding site [ion binding]; other site 1074252003998 putative aspartate binding site [chemical binding]; other site 1074252003999 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1074252004000 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1074252004001 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1074252004002 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1074252004003 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1074252004004 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1074252004005 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1074252004006 dimer interface [polypeptide binding]; other site 1074252004007 active site 1074252004008 catalytic residue [active] 1074252004009 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1074252004010 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1074252004011 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1074252004012 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1074252004013 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1074252004014 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1074252004015 active site 1074252004016 trimer interface [polypeptide binding]; other site 1074252004017 substrate binding site [chemical binding]; other site 1074252004018 CoA binding site [chemical binding]; other site 1074252004019 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1074252004020 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1074252004021 metal binding site [ion binding]; metal-binding site 1074252004022 dimer interface [polypeptide binding]; other site 1074252004023 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1074252004024 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1074252004025 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1074252004026 catalytic residue [active] 1074252004027 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1074252004028 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1074252004029 active site 1074252004030 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1074252004031 substrate binding site [chemical binding]; other site 1074252004032 catalytic residues [active] 1074252004033 dimer interface [polypeptide binding]; other site 1074252004034 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1074252004035 DNA-binding site [nucleotide binding]; DNA binding site 1074252004036 RNA-binding motif; other site 1074252004037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 1074252004038 acylphosphatase; Provisional; Region: PRK14431 1074252004039 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1074252004040 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1074252004041 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1074252004042 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1074252004043 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1074252004044 metal ion-dependent adhesion site (MIDAS); other site 1074252004045 MoxR-like ATPases [General function prediction only]; Region: COG0714 1074252004046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252004047 Walker A motif; other site 1074252004048 ATP binding site [chemical binding]; other site 1074252004049 Walker B motif; other site 1074252004050 arginine finger; other site 1074252004051 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1074252004052 active site 1074252004053 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1074252004054 active site 1074252004055 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1074252004056 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1074252004057 E3 interaction surface; other site 1074252004058 lipoyl attachment site [posttranslational modification]; other site 1074252004059 e3 binding domain; Region: E3_binding; pfam02817 1074252004060 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1074252004061 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1074252004062 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1074252004063 TPP-binding site [chemical binding]; other site 1074252004064 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1074252004065 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1074252004066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1074252004067 HAMP domain; Region: HAMP; pfam00672 1074252004068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1074252004069 dimer interface [polypeptide binding]; other site 1074252004070 phosphorylation site [posttranslational modification] 1074252004071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252004072 ATP binding site [chemical binding]; other site 1074252004073 Mg2+ binding site [ion binding]; other site 1074252004074 G-X-G motif; other site 1074252004075 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1074252004076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252004077 active site 1074252004078 phosphorylation site [posttranslational modification] 1074252004079 intermolecular recognition site; other site 1074252004080 dimerization interface [polypeptide binding]; other site 1074252004081 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1074252004082 DNA binding site [nucleotide binding] 1074252004083 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1074252004084 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1074252004085 active site 1074252004086 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1074252004087 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1074252004088 active site 1074252004089 homodimer interface [polypeptide binding]; other site 1074252004090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252004091 Coenzyme A binding pocket [chemical binding]; other site 1074252004092 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1074252004093 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1074252004094 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1074252004095 protein binding site [polypeptide binding]; other site 1074252004096 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1074252004097 Catalytic dyad [active] 1074252004098 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1074252004099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 1074252004100 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1074252004101 HPr interaction site; other site 1074252004102 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1074252004103 active site 1074252004104 phosphorylation site [posttranslational modification] 1074252004105 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1074252004106 SelR domain; Region: SelR; pfam01641 1074252004107 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1074252004108 EDD domain protein, DegV family; Region: DegV; TIGR00762 1074252004109 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1074252004110 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1074252004111 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1074252004112 folate binding site [chemical binding]; other site 1074252004113 NADP+ binding site [chemical binding]; other site 1074252004114 thymidylate synthase; Region: thym_sym; TIGR03284 1074252004115 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1074252004116 dimerization interface [polypeptide binding]; other site 1074252004117 active site 1074252004118 Disulphide isomerase; Region: Disulph_isomer; cl05813 1074252004119 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1074252004120 Virulence factor; Region: Virulence_fact; pfam13769 1074252004121 HEAT repeats; Region: HEAT_2; pfam13646 1074252004122 HEAT repeat; Region: HEAT; pfam02985 1074252004123 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1074252004124 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1074252004125 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1074252004126 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1074252004127 RNA/DNA hybrid binding site [nucleotide binding]; other site 1074252004128 active site 1074252004130 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1074252004131 Amino acid permease; Region: AA_permease_2; pfam13520 1074252004132 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1074252004133 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1074252004134 tetramer interface [polypeptide binding]; other site 1074252004135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252004136 catalytic residue [active] 1074252004137 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1074252004138 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1074252004139 hexamer interface [polypeptide binding]; other site 1074252004140 ligand binding site [chemical binding]; other site 1074252004141 putative active site [active] 1074252004142 NAD(P) binding site [chemical binding]; other site 1074252004143 5'-3' exonuclease; Region: 53EXOc; smart00475 1074252004144 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1074252004145 active site 1074252004146 metal binding site 1 [ion binding]; metal-binding site 1074252004147 putative 5' ssDNA interaction site; other site 1074252004148 metal binding site 3; metal-binding site 1074252004149 metal binding site 2 [ion binding]; metal-binding site 1074252004150 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1074252004151 putative DNA binding site [nucleotide binding]; other site 1074252004152 putative metal binding site [ion binding]; other site 1074252004153 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1074252004154 Dynamin family; Region: Dynamin_N; pfam00350 1074252004155 G1 box; other site 1074252004156 GTP/Mg2+ binding site [chemical binding]; other site 1074252004157 G2 box; other site 1074252004158 Switch I region; other site 1074252004159 G3 box; other site 1074252004160 Switch II region; other site 1074252004161 G4 box; other site 1074252004162 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1074252004163 Dynamin family; Region: Dynamin_N; pfam00350 1074252004164 G1 box; other site 1074252004165 GTP/Mg2+ binding site [chemical binding]; other site 1074252004166 G2 box; other site 1074252004167 Switch I region; other site 1074252004168 G3 box; other site 1074252004169 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1074252004170 G3 box; other site 1074252004171 Switch II region; other site 1074252004172 GTP/Mg2+ binding site [chemical binding]; other site 1074252004173 G4 box; other site 1074252004174 G5 box; other site 1074252004175 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1074252004176 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1074252004177 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1074252004178 Cobalt transport protein component CbiN; Region: CbiN; cl00842 1074252004179 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1074252004180 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1074252004181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1074252004182 cell division protein GpsB; Provisional; Region: PRK14127 1074252004183 DivIVA domain; Region: DivI1A_domain; TIGR03544 1074252004184 hypothetical protein; Provisional; Region: PRK13660 1074252004185 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1074252004186 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1074252004187 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1074252004188 Transglycosylase; Region: Transgly; pfam00912 1074252004189 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1074252004190 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1074252004191 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1074252004192 minor groove reading motif; other site 1074252004193 helix-hairpin-helix signature motif; other site 1074252004194 substrate binding pocket [chemical binding]; other site 1074252004195 active site 1074252004196 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1074252004197 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1074252004198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1074252004199 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1074252004200 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1074252004201 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1074252004202 putative dimer interface [polypeptide binding]; other site 1074252004203 putative anticodon binding site; other site 1074252004204 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1074252004205 homodimer interface [polypeptide binding]; other site 1074252004206 motif 1; other site 1074252004207 motif 2; other site 1074252004208 active site 1074252004209 motif 3; other site 1074252004210 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1074252004211 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1074252004212 active site 1074252004213 catalytic site [active] 1074252004214 substrate binding site [chemical binding]; other site 1074252004215 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1074252004216 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1074252004217 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1074252004218 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1074252004219 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1074252004220 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1074252004221 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1074252004222 active site 1074252004223 NTP binding site [chemical binding]; other site 1074252004224 metal binding triad [ion binding]; metal-binding site 1074252004225 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1074252004226 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1074252004227 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1074252004228 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1074252004229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1074252004230 homodimer interface [polypeptide binding]; other site 1074252004231 metal binding site [ion binding]; metal-binding site 1074252004232 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1074252004233 Predicted membrane protein [Function unknown]; Region: COG4347 1074252004234 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1074252004235 UPF0302 domain; Region: UPF0302; pfam08864 1074252004236 A short protein domain of unknown function; Region: IDEAL; smart00914 1074252004237 TPR repeat; Region: TPR_11; pfam13414 1074252004238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1074252004239 binding surface 1074252004240 TPR motif; other site 1074252004241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1074252004242 TPR motif; other site 1074252004243 binding surface 1074252004244 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1074252004245 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1074252004246 hinge; other site 1074252004247 active site 1074252004248 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1074252004249 active site 1074252004250 NAD binding site [chemical binding]; other site 1074252004251 metal binding site [ion binding]; metal-binding site 1074252004252 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1074252004253 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1074252004254 Tetramer interface [polypeptide binding]; other site 1074252004255 active site 1074252004256 FMN-binding site [chemical binding]; other site 1074252004257 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1074252004258 active site 1074252004259 multimer interface [polypeptide binding]; other site 1074252004260 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1074252004261 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1074252004262 substrate binding pocket [chemical binding]; other site 1074252004263 chain length determination region; other site 1074252004264 substrate-Mg2+ binding site; other site 1074252004265 catalytic residues [active] 1074252004266 aspartate-rich region 1; other site 1074252004267 active site lid residues [active] 1074252004268 aspartate-rich region 2; other site 1074252004269 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1074252004270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252004271 S-adenosylmethionine binding site [chemical binding]; other site 1074252004272 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1074252004273 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1074252004274 IHF dimer interface [polypeptide binding]; other site 1074252004275 IHF - DNA interface [nucleotide binding]; other site 1074252004276 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1074252004277 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1074252004278 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1074252004279 GTP-binding protein Der; Reviewed; Region: PRK00093 1074252004280 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1074252004281 G1 box; other site 1074252004282 GTP/Mg2+ binding site [chemical binding]; other site 1074252004283 Switch I region; other site 1074252004284 G2 box; other site 1074252004285 Switch II region; other site 1074252004286 G3 box; other site 1074252004287 G4 box; other site 1074252004288 G5 box; other site 1074252004289 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1074252004290 G1 box; other site 1074252004291 GTP/Mg2+ binding site [chemical binding]; other site 1074252004292 Switch I region; other site 1074252004293 G2 box; other site 1074252004294 G3 box; other site 1074252004295 Switch II region; other site 1074252004296 G4 box; other site 1074252004297 G5 box; other site 1074252004298 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1074252004299 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1074252004300 RNA binding site [nucleotide binding]; other site 1074252004301 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1074252004302 RNA binding site [nucleotide binding]; other site 1074252004303 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1074252004304 RNA binding site [nucleotide binding]; other site 1074252004305 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1074252004306 RNA binding site [nucleotide binding]; other site 1074252004307 cytidylate kinase; Provisional; Region: cmk; PRK00023 1074252004308 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1074252004309 CMP-binding site; other site 1074252004310 The sites determining sugar specificity; other site 1074252004311 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1074252004312 active site 1074252004313 homotetramer interface [polypeptide binding]; other site 1074252004314 homodimer interface [polypeptide binding]; other site 1074252004315 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1074252004316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1074252004317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252004318 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1074252004319 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1074252004320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252004321 ATP binding site [chemical binding]; other site 1074252004322 putative Mg++ binding site [ion binding]; other site 1074252004323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1074252004324 nucleotide binding region [chemical binding]; other site 1074252004325 ATP-binding site [chemical binding]; other site 1074252004326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1074252004327 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1074252004328 Predicted membrane protein [Function unknown]; Region: COG3601 1074252004329 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1074252004330 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1074252004331 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1074252004332 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1074252004334 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1074252004335 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1074252004336 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1074252004337 CHAP domain; Region: CHAP; pfam05257 1074252004338 Small integral membrane protein [Function unknown]; Region: COG5546 1074252004339 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 1074252004340 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1074252004341 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 1074252004342 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1074252004343 hypothetical protein; Provisional; Region: PRK05926 1074252004344 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1074252004345 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1074252004346 Phage tail protein; Region: Sipho_tail; pfam05709 1074252004347 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 1074252004348 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1074252004349 linker region; other site 1074252004350 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1074252004351 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1074252004352 dimer interface [polypeptide binding]; other site 1074252004353 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1074252004354 Peptidase family M23; Region: Peptidase_M23; pfam01551 1074252004355 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1074252004356 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1074252004357 catalytic residue [active] 1074252004358 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1074252004359 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1074252004360 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1074252004361 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1074252004362 oligomerization interface [polypeptide binding]; other site 1074252004363 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1074252004364 Phage capsid family; Region: Phage_capsid; pfam05065 1074252004365 Clp protease; Region: CLP_protease; pfam00574 1074252004366 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1074252004367 oligomer interface [polypeptide binding]; other site 1074252004368 active site residues [active] 1074252004369 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1074252004370 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1074252004371 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1074252004372 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1074252004373 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1074252004374 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1074252004375 active site 1074252004376 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1074252004377 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1074252004378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252004379 ATP binding site [chemical binding]; other site 1074252004380 putative Mg++ binding site [ion binding]; other site 1074252004381 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1074252004382 VRR-NUC domain; Region: VRR_NUC; pfam08774 1074252004383 Virulence-associated protein E; Region: VirE; pfam05272 1074252004384 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1074252004385 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 1074252004386 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1074252004387 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1074252004388 trimer interface [polypeptide binding]; other site 1074252004389 active site 1074252004390 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1074252004391 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1074252004392 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 1074252004393 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1074252004394 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 1074252004395 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 1074252004396 active site 1074252004397 DNA binding site [nucleotide binding] 1074252004398 catalytic site [active] 1074252004399 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1074252004400 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1074252004401 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1074252004402 Homeodomain-like domain; Region: HTH_23; pfam13384 1074252004403 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1074252004404 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 1074252004405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1074252004406 non-specific DNA binding site [nucleotide binding]; other site 1074252004407 salt bridge; other site 1074252004408 sequence-specific DNA binding site [nucleotide binding]; other site 1074252004409 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1074252004410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1074252004411 non-specific DNA binding site [nucleotide binding]; other site 1074252004412 salt bridge; other site 1074252004413 sequence-specific DNA binding site [nucleotide binding]; other site 1074252004414 Predicted transcriptional regulator [Transcription]; Region: COG2932 1074252004415 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1074252004416 Catalytic site [active] 1074252004417 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1074252004418 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1074252004419 Int/Topo IB signature motif; other site 1074252004420 transposase/IS protein; Provisional; Region: PRK09183 1074252004421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252004422 Walker A motif; other site 1074252004423 ATP binding site [chemical binding]; other site 1074252004424 Walker B motif; other site 1074252004425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1074252004426 Integrase core domain; Region: rve; pfam00665 1074252004427 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1074252004428 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1074252004429 dimerization interface [polypeptide binding]; other site 1074252004430 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1074252004431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1074252004432 dimer interface [polypeptide binding]; other site 1074252004433 phosphorylation site [posttranslational modification] 1074252004434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252004435 ATP binding site [chemical binding]; other site 1074252004436 Mg2+ binding site [ion binding]; other site 1074252004437 G-X-G motif; other site 1074252004438 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1074252004439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252004440 active site 1074252004441 phosphorylation site [posttranslational modification] 1074252004442 intermolecular recognition site; other site 1074252004443 dimerization interface [polypeptide binding]; other site 1074252004444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1074252004445 DNA binding site [nucleotide binding] 1074252004446 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1074252004447 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1074252004448 RNA binding surface [nucleotide binding]; other site 1074252004449 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1074252004450 active site 1074252004451 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1074252004452 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1074252004453 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1074252004454 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1074252004455 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1074252004456 active site 1074252004457 Int/Topo IB signature motif; other site 1074252004458 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1074252004459 metal binding site 2 [ion binding]; metal-binding site 1074252004460 putative DNA binding helix; other site 1074252004461 metal binding site 1 [ion binding]; metal-binding site 1074252004462 dimer interface [polypeptide binding]; other site 1074252004463 structural Zn2+ binding site [ion binding]; other site 1074252004464 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1074252004465 dimer interface [polypeptide binding]; other site 1074252004466 ADP-ribose binding site [chemical binding]; other site 1074252004467 active site 1074252004468 nudix motif; other site 1074252004469 metal binding site [ion binding]; metal-binding site 1074252004470 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1074252004471 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1074252004472 active site 1074252004473 catalytic tetrad [active] 1074252004474 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1074252004475 classical (c) SDRs; Region: SDR_c; cd05233 1074252004476 NAD(P) binding site [chemical binding]; other site 1074252004477 active site 1074252004478 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1074252004479 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1074252004480 ribonuclease Z; Region: RNase_Z; TIGR02651 1074252004481 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1074252004482 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1074252004483 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1074252004484 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1074252004485 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1074252004486 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1074252004487 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1074252004488 Ca binding site [ion binding]; other site 1074252004489 active site 1074252004490 catalytic site [active] 1074252004491 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1074252004492 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1074252004493 DNA binding site [nucleotide binding] 1074252004494 domain linker motif; other site 1074252004495 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1074252004496 putative ligand binding site [chemical binding]; other site 1074252004497 putative dimerization interface [polypeptide binding]; other site 1074252004498 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1074252004499 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1074252004500 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1074252004501 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1074252004502 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1074252004503 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1074252004504 peptidase T-like protein; Region: PepT-like; TIGR01883 1074252004505 metal binding site [ion binding]; metal-binding site 1074252004506 putative dimer interface [polypeptide binding]; other site 1074252004507 Predicted membrane protein [Function unknown]; Region: COG4129 1074252004508 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1074252004509 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1074252004510 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1074252004511 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1074252004512 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1074252004513 E3 interaction surface; other site 1074252004514 lipoyl attachment site [posttranslational modification]; other site 1074252004515 e3 binding domain; Region: E3_binding; pfam02817 1074252004516 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1074252004517 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1074252004518 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1074252004519 alpha subunit interface [polypeptide binding]; other site 1074252004520 TPP binding site [chemical binding]; other site 1074252004521 heterodimer interface [polypeptide binding]; other site 1074252004522 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1074252004523 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1074252004524 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1074252004525 tetramer interface [polypeptide binding]; other site 1074252004526 TPP-binding site [chemical binding]; other site 1074252004527 heterodimer interface [polypeptide binding]; other site 1074252004528 phosphorylation loop region [posttranslational modification] 1074252004529 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1074252004530 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1074252004531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252004532 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1074252004533 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1074252004534 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1074252004535 Walker A/P-loop; other site 1074252004536 ATP binding site [chemical binding]; other site 1074252004537 Q-loop/lid; other site 1074252004538 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1074252004539 ABC transporter signature motif; other site 1074252004540 Walker B; other site 1074252004541 D-loop; other site 1074252004542 H-loop/switch region; other site 1074252004543 arginine repressor; Provisional; Region: PRK04280 1074252004544 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1074252004545 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1074252004546 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1074252004547 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1074252004548 substrate binding pocket [chemical binding]; other site 1074252004549 chain length determination region; other site 1074252004550 substrate-Mg2+ binding site; other site 1074252004551 catalytic residues [active] 1074252004552 aspartate-rich region 1; other site 1074252004553 active site lid residues [active] 1074252004554 aspartate-rich region 2; other site 1074252004555 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1074252004556 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1074252004557 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1074252004558 generic binding surface II; other site 1074252004559 generic binding surface I; other site 1074252004560 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1074252004561 putative RNA binding site [nucleotide binding]; other site 1074252004562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1074252004563 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1074252004564 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1074252004565 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1074252004566 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1074252004567 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1074252004568 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1074252004569 carboxyltransferase (CT) interaction site; other site 1074252004570 biotinylation site [posttranslational modification]; other site 1074252004571 elongation factor P; Validated; Region: PRK00529 1074252004572 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1074252004573 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1074252004574 RNA binding site [nucleotide binding]; other site 1074252004575 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1074252004576 RNA binding site [nucleotide binding]; other site 1074252004577 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1074252004578 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1074252004579 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1074252004580 active site 1074252004581 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1074252004582 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1074252004583 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1074252004584 active site residue [active] 1074252004585 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1074252004586 tetramer interface [polypeptide binding]; other site 1074252004587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252004588 catalytic residue [active] 1074252004589 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1074252004590 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1074252004591 tetramer interface [polypeptide binding]; other site 1074252004592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252004593 catalytic residue [active] 1074252004594 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1074252004595 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1074252004596 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1074252004597 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1074252004598 ADP binding site [chemical binding]; other site 1074252004599 magnesium binding site [ion binding]; other site 1074252004600 putative shikimate binding site; other site 1074252004601 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1074252004602 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1074252004603 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1074252004604 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1074252004605 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1074252004606 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1074252004607 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1074252004608 Type II/IV secretion system protein; Region: T2SE; pfam00437 1074252004609 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1074252004610 Walker A motif; other site 1074252004611 ATP binding site [chemical binding]; other site 1074252004612 Walker B motif; other site 1074252004613 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1074252004614 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1074252004615 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1074252004616 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1074252004617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1074252004618 Rhomboid family; Region: Rhomboid; pfam01694 1074252004619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1074252004620 binding surface 1074252004621 TPR motif; other site 1074252004622 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1074252004623 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1074252004624 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1074252004625 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1074252004626 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1074252004627 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1074252004628 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1074252004629 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1074252004630 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1074252004631 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1074252004632 metal binding site 2 [ion binding]; metal-binding site 1074252004633 putative DNA binding helix; other site 1074252004634 metal binding site 1 [ion binding]; metal-binding site 1074252004635 dimer interface [polypeptide binding]; other site 1074252004636 structural Zn2+ binding site [ion binding]; other site 1074252004637 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1074252004638 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252004639 ABC-ATPase subunit interface; other site 1074252004640 dimer interface [polypeptide binding]; other site 1074252004641 putative PBP binding regions; other site 1074252004642 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1074252004643 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1074252004644 endonuclease IV; Provisional; Region: PRK01060 1074252004645 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1074252004646 AP (apurinic/apyrimidinic) site pocket; other site 1074252004647 DNA interaction; other site 1074252004648 Metal-binding active site; metal-binding site 1074252004649 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1074252004650 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1074252004651 ATP binding site [chemical binding]; other site 1074252004652 Mg++ binding site [ion binding]; other site 1074252004653 motif III; other site 1074252004654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1074252004655 nucleotide binding region [chemical binding]; other site 1074252004656 ATP-binding site [chemical binding]; other site 1074252004657 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1074252004658 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1074252004659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1074252004660 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1074252004661 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1074252004662 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1074252004663 Family of unknown function (DUF633); Region: DUF633; pfam04816 1074252004664 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1074252004665 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1074252004666 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1074252004667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1074252004668 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1074252004669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1074252004670 DNA binding residues [nucleotide binding] 1074252004671 DNA primase, catalytic core; Region: dnaG; TIGR01391 1074252004672 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1074252004673 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1074252004674 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1074252004675 active site 1074252004676 metal binding site [ion binding]; metal-binding site 1074252004677 interdomain interaction site; other site 1074252004678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1074252004679 HTH domain; Region: HTH_11; pfam08279 1074252004680 FOG: CBS domain [General function prediction only]; Region: COG0517 1074252004681 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1074252004682 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1074252004683 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1074252004684 motif 1; other site 1074252004685 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1074252004686 active site 1074252004687 motif 2; other site 1074252004688 motif 3; other site 1074252004689 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1074252004690 anticodon binding site; other site 1074252004691 DNA repair protein RecO; Region: reco; TIGR00613 1074252004692 Recombination protein O N terminal; Region: RecO_N; pfam11967 1074252004693 Recombination protein O C terminal; Region: RecO_C; pfam02565 1074252004694 GTPase Era; Reviewed; Region: era; PRK00089 1074252004695 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1074252004696 G1 box; other site 1074252004697 GTP/Mg2+ binding site [chemical binding]; other site 1074252004698 Switch I region; other site 1074252004699 G2 box; other site 1074252004700 Switch II region; other site 1074252004701 G3 box; other site 1074252004702 G4 box; other site 1074252004703 G5 box; other site 1074252004704 KH domain; Region: KH_2; pfam07650 1074252004705 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1074252004706 active site 1074252004707 catalytic motif [active] 1074252004708 Zn binding site [ion binding]; other site 1074252004709 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1074252004710 metal-binding heat shock protein; Provisional; Region: PRK00016 1074252004711 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1074252004712 PhoH-like protein; Region: PhoH; pfam02562 1074252004713 hypothetical protein; Provisional; Region: PRK13665 1074252004714 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1074252004715 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1074252004716 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1074252004717 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1074252004718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1074252004719 FeS/SAM binding site; other site 1074252004720 TRAM domain; Region: TRAM; cl01282 1074252004721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1074252004722 RNA methyltransferase, RsmE family; Region: TIGR00046 1074252004723 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1074252004724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252004725 S-adenosylmethionine binding site [chemical binding]; other site 1074252004726 chaperone protein DnaJ; Provisional; Region: PRK14280 1074252004727 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1074252004728 HSP70 interaction site [polypeptide binding]; other site 1074252004729 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1074252004730 substrate binding site [polypeptide binding]; other site 1074252004731 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1074252004732 Zn binding sites [ion binding]; other site 1074252004733 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1074252004734 dimer interface [polypeptide binding]; other site 1074252004735 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1074252004736 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1074252004737 nucleotide binding site [chemical binding]; other site 1074252004738 NEF interaction site [polypeptide binding]; other site 1074252004739 SBD interface [polypeptide binding]; other site 1074252004740 heat shock protein GrpE; Provisional; Region: PRK14140 1074252004741 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1074252004742 dimer interface [polypeptide binding]; other site 1074252004743 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1074252004744 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1074252004745 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1074252004746 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 1074252004747 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1074252004748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1074252004749 FeS/SAM binding site; other site 1074252004750 HemN C-terminal domain; Region: HemN_C; pfam06969 1074252004751 GTP-binding protein LepA; Provisional; Region: PRK05433 1074252004752 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1074252004753 G1 box; other site 1074252004754 putative GEF interaction site [polypeptide binding]; other site 1074252004755 GTP/Mg2+ binding site [chemical binding]; other site 1074252004756 Switch I region; other site 1074252004757 G2 box; other site 1074252004758 G3 box; other site 1074252004759 Switch II region; other site 1074252004760 G4 box; other site 1074252004761 G5 box; other site 1074252004762 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1074252004763 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1074252004764 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1074252004765 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1074252004766 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1074252004767 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1074252004768 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1074252004769 Competence protein; Region: Competence; pfam03772 1074252004770 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1074252004771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1074252004772 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1074252004773 catalytic motif [active] 1074252004774 Zn binding site [ion binding]; other site 1074252004775 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1074252004776 SLBB domain; Region: SLBB; pfam10531 1074252004777 Helix-hairpin-helix motif; Region: HHH; pfam00633 1074252004778 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1074252004779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252004780 S-adenosylmethionine binding site [chemical binding]; other site 1074252004781 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1074252004782 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1074252004783 Zn2+ binding site [ion binding]; other site 1074252004784 Mg2+ binding site [ion binding]; other site 1074252004785 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1074252004786 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1074252004787 active site 1074252004788 (T/H)XGH motif; other site 1074252004789 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1074252004790 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1074252004791 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1074252004792 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1074252004793 shikimate binding site; other site 1074252004794 NAD(P) binding site [chemical binding]; other site 1074252004795 GTPase YqeH; Provisional; Region: PRK13796 1074252004796 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1074252004797 GTP/Mg2+ binding site [chemical binding]; other site 1074252004798 G4 box; other site 1074252004799 G5 box; other site 1074252004800 G1 box; other site 1074252004801 Switch I region; other site 1074252004802 G2 box; other site 1074252004803 G3 box; other site 1074252004804 Switch II region; other site 1074252004805 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1074252004806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252004807 active site 1074252004808 motif I; other site 1074252004809 motif II; other site 1074252004810 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1074252004811 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1074252004812 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1074252004813 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252004814 Fic family protein [Function unknown]; Region: COG3177 1074252004815 Fic/DOC family; Region: Fic; pfam02661 1074252004816 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1074252004817 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1074252004818 putative active site [active] 1074252004819 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1074252004820 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1074252004821 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1074252004822 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1074252004823 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1074252004824 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1074252004825 carboxyltransferase (CT) interaction site; other site 1074252004826 biotinylation site [posttranslational modification]; other site 1074252004827 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1074252004828 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1074252004829 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1074252004830 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1074252004831 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1074252004832 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1074252004833 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1074252004834 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1074252004835 Sugar specificity; other site 1074252004836 Pyrimidine base specificity; other site 1074252004837 ATP-binding site [chemical binding]; other site 1074252004838 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1074252004839 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1074252004840 Peptidase family U32; Region: Peptidase_U32; pfam01136 1074252004841 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1074252004842 Peptidase family U32; Region: Peptidase_U32; pfam01136 1074252004843 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1074252004844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252004845 S-adenosylmethionine binding site [chemical binding]; other site 1074252004846 hypothetical protein; Provisional; Region: PRK13678 1074252004847 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1074252004848 hypothetical protein; Provisional; Region: PRK05473 1074252004849 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1074252004850 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1074252004851 motif 1; other site 1074252004852 active site 1074252004853 motif 2; other site 1074252004854 motif 3; other site 1074252004855 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1074252004856 DHHA1 domain; Region: DHHA1; pfam02272 1074252004857 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1074252004858 AAA domain; Region: AAA_30; pfam13604 1074252004859 Family description; Region: UvrD_C_2; pfam13538 1074252004860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1074252004861 binding surface 1074252004862 TPR motif; other site 1074252004863 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1074252004864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1074252004865 binding surface 1074252004866 TPR motif; other site 1074252004867 TPR repeat; Region: TPR_11; pfam13414 1074252004868 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1074252004869 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1074252004870 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1074252004871 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1074252004872 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1074252004873 catalytic residue [active] 1074252004874 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1074252004875 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1074252004876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1074252004877 Predicted transcriptional regulator [Transcription]; Region: COG1959 1074252004878 Transcriptional regulator; Region: Rrf2; pfam02082 1074252004879 recombination factor protein RarA; Reviewed; Region: PRK13342 1074252004880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252004881 Walker A motif; other site 1074252004882 ATP binding site [chemical binding]; other site 1074252004883 Walker B motif; other site 1074252004884 arginine finger; other site 1074252004885 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1074252004886 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1074252004887 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1074252004888 putative ATP binding site [chemical binding]; other site 1074252004889 putative substrate interface [chemical binding]; other site 1074252004890 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1074252004891 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1074252004892 dimer interface [polypeptide binding]; other site 1074252004893 anticodon binding site; other site 1074252004894 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1074252004895 homodimer interface [polypeptide binding]; other site 1074252004896 motif 1; other site 1074252004897 active site 1074252004898 motif 2; other site 1074252004899 GAD domain; Region: GAD; pfam02938 1074252004900 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1074252004901 motif 3; other site 1074252004902 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1074252004903 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1074252004904 dimer interface [polypeptide binding]; other site 1074252004905 motif 1; other site 1074252004906 active site 1074252004907 motif 2; other site 1074252004908 motif 3; other site 1074252004909 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1074252004910 anticodon binding site; other site 1074252004911 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1074252004912 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1074252004913 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1074252004914 active site 1074252004915 metal binding site [ion binding]; metal-binding site 1074252004917 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1074252004918 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1074252004919 Zn2+ binding site [ion binding]; other site 1074252004920 Mg2+ binding site [ion binding]; other site 1074252004921 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1074252004922 synthetase active site [active] 1074252004923 NTP binding site [chemical binding]; other site 1074252004924 metal binding site [ion binding]; metal-binding site 1074252004925 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1074252004926 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1074252004927 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1074252004928 active site 1074252004929 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1074252004930 DHH family; Region: DHH; pfam01368 1074252004931 DHHA1 domain; Region: DHHA1; pfam02272 1074252004932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1074252004933 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1074252004934 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1074252004935 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1074252004936 Protein export membrane protein; Region: SecD_SecF; pfam02355 1074252004937 Preprotein translocase subunit; Region: YajC; pfam02699 1074252004938 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1074252004939 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1074252004940 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1074252004941 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1074252004942 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1074252004943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252004944 Walker A motif; other site 1074252004945 ATP binding site [chemical binding]; other site 1074252004946 Walker B motif; other site 1074252004947 arginine finger; other site 1074252004948 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1074252004949 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1074252004950 RuvA N terminal domain; Region: RuvA_N; pfam01330 1074252004951 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1074252004952 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 1074252004953 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1074252004954 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1074252004955 GTP1/OBG; Region: GTP1_OBG; pfam01018 1074252004956 Obg GTPase; Region: Obg; cd01898 1074252004957 G1 box; other site 1074252004958 GTP/Mg2+ binding site [chemical binding]; other site 1074252004959 Switch I region; other site 1074252004960 G2 box; other site 1074252004961 G3 box; other site 1074252004962 Switch II region; other site 1074252004963 G4 box; other site 1074252004964 G5 box; other site 1074252004965 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1074252004966 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1074252004967 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1074252004968 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1074252004969 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1074252004970 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1074252004971 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1074252004972 rod shape-determining protein MreC; Region: MreC; pfam04085 1074252004973 hypothetical protein; Reviewed; Region: PRK00024 1074252004974 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1074252004975 MPN+ (JAMM) motif; other site 1074252004976 Zinc-binding site [ion binding]; other site 1074252004977 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1074252004978 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1074252004979 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1074252004980 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1074252004981 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1074252004982 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1074252004983 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1074252004984 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1074252004985 active site 1074252004986 HIGH motif; other site 1074252004987 nucleotide binding site [chemical binding]; other site 1074252004988 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1074252004989 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1074252004990 active site 1074252004991 KMSKS motif; other site 1074252004992 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1074252004993 tRNA binding surface [nucleotide binding]; other site 1074252004994 anticodon binding site; other site 1074252004995 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1074252004996 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1074252004997 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1074252004998 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1074252004999 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1074252005000 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1074252005001 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1074252005002 inhibitor-cofactor binding pocket; inhibition site 1074252005003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252005004 catalytic residue [active] 1074252005005 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1074252005006 dimer interface [polypeptide binding]; other site 1074252005007 active site 1074252005008 Schiff base residues; other site 1074252005009 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1074252005010 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1074252005011 active site 1074252005012 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1074252005013 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1074252005014 domain interfaces; other site 1074252005015 active site 1074252005016 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 1074252005017 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1074252005018 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1074252005019 tRNA; other site 1074252005020 putative tRNA binding site [nucleotide binding]; other site 1074252005021 putative NADP binding site [chemical binding]; other site 1074252005022 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1074252005023 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1074252005024 G1 box; other site 1074252005025 GTP/Mg2+ binding site [chemical binding]; other site 1074252005026 Switch I region; other site 1074252005027 G2 box; other site 1074252005028 G3 box; other site 1074252005029 Switch II region; other site 1074252005030 G4 box; other site 1074252005031 G5 box; other site 1074252005032 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1074252005033 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1074252005034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252005035 Walker A motif; other site 1074252005036 ATP binding site [chemical binding]; other site 1074252005037 Walker B motif; other site 1074252005038 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1074252005039 trigger factor; Provisional; Region: tig; PRK01490 1074252005040 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1074252005041 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1074252005042 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1074252005043 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1074252005044 23S rRNA binding site [nucleotide binding]; other site 1074252005045 L21 binding site [polypeptide binding]; other site 1074252005046 L13 binding site [polypeptide binding]; other site 1074252005047 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1074252005048 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1074252005049 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1074252005050 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1074252005051 lysine transporter; Provisional; Region: PRK10836 1074252005052 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1074252005053 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1074252005054 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1074252005055 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1074252005056 active site 1074252005057 dimer interface [polypeptide binding]; other site 1074252005058 motif 1; other site 1074252005059 motif 2; other site 1074252005060 motif 3; other site 1074252005061 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1074252005062 anticodon binding site; other site 1074252005063 primosomal protein DnaI; Reviewed; Region: PRK08939 1074252005064 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1074252005065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252005066 Walker A motif; other site 1074252005067 ATP binding site [chemical binding]; other site 1074252005068 Walker B motif; other site 1074252005069 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1074252005070 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1074252005071 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1074252005072 ATP cone domain; Region: ATP-cone; pfam03477 1074252005073 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1074252005074 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1074252005075 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1074252005076 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1074252005077 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1074252005078 CoA-binding site [chemical binding]; other site 1074252005079 ATP-binding [chemical binding]; other site 1074252005080 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1074252005081 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1074252005082 DNA binding site [nucleotide binding] 1074252005083 catalytic residue [active] 1074252005084 H2TH interface [polypeptide binding]; other site 1074252005085 putative catalytic residues [active] 1074252005086 turnover-facilitating residue; other site 1074252005087 intercalation triad [nucleotide binding]; other site 1074252005088 8OG recognition residue [nucleotide binding]; other site 1074252005089 putative reading head residues; other site 1074252005090 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1074252005091 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1074252005092 DNA polymerase I; Provisional; Region: PRK05755 1074252005093 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1074252005094 active site 1074252005095 metal binding site 1 [ion binding]; metal-binding site 1074252005096 putative 5' ssDNA interaction site; other site 1074252005097 metal binding site 3; metal-binding site 1074252005098 metal binding site 2 [ion binding]; metal-binding site 1074252005099 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1074252005100 putative DNA binding site [nucleotide binding]; other site 1074252005101 putative metal binding site [ion binding]; other site 1074252005102 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1074252005103 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1074252005104 active site 1074252005105 DNA binding site [nucleotide binding] 1074252005106 catalytic site [active] 1074252005107 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1074252005108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1074252005109 dimer interface [polypeptide binding]; other site 1074252005110 phosphorylation site [posttranslational modification] 1074252005111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252005112 ATP binding site [chemical binding]; other site 1074252005113 Mg2+ binding site [ion binding]; other site 1074252005114 G-X-G motif; other site 1074252005115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1074252005116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252005117 active site 1074252005118 phosphorylation site [posttranslational modification] 1074252005119 intermolecular recognition site; other site 1074252005120 dimerization interface [polypeptide binding]; other site 1074252005121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1074252005122 DNA binding site [nucleotide binding] 1074252005123 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1074252005124 isocitrate dehydrogenase; Validated; Region: PRK07362 1074252005125 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1074252005126 dimer interface [polypeptide binding]; other site 1074252005127 Citrate synthase; Region: Citrate_synt; pfam00285 1074252005128 active site 1074252005129 citrylCoA binding site [chemical binding]; other site 1074252005130 oxalacetate/citrate binding site [chemical binding]; other site 1074252005131 coenzyme A binding site [chemical binding]; other site 1074252005132 catalytic triad [active] 1074252005133 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1074252005134 pyruvate kinase; Provisional; Region: PRK06354 1074252005135 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1074252005136 domain interfaces; other site 1074252005137 active site 1074252005138 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1074252005139 6-phosphofructokinase; Provisional; Region: PRK03202 1074252005140 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1074252005141 active site 1074252005142 ADP/pyrophosphate binding site [chemical binding]; other site 1074252005143 dimerization interface [polypeptide binding]; other site 1074252005144 allosteric effector site; other site 1074252005145 fructose-1,6-bisphosphate binding site; other site 1074252005146 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1074252005147 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1074252005148 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1074252005149 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1074252005150 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1074252005151 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1074252005152 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1074252005153 putative NAD(P) binding site [chemical binding]; other site 1074252005154 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1074252005155 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1074252005156 active site 1074252005157 PHP Thumb interface [polypeptide binding]; other site 1074252005158 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1074252005159 generic binding surface I; other site 1074252005160 generic binding surface II; other site 1074252005161 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1074252005162 DHH family; Region: DHH; pfam01368 1074252005163 DHHA1 domain; Region: DHHA1; pfam02272 1074252005164 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1074252005165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1074252005166 DNA-binding site [nucleotide binding]; DNA binding site 1074252005167 DRTGG domain; Region: DRTGG; pfam07085 1074252005168 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1074252005169 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1074252005170 active site 2 [active] 1074252005171 active site 1 [active] 1074252005172 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1074252005173 Ligand Binding Site [chemical binding]; other site 1074252005174 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1074252005175 metal-dependent hydrolase; Provisional; Region: PRK00685 1074252005176 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1074252005177 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1074252005178 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1074252005179 active site 1074252005180 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1074252005181 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1074252005182 hexamer interface [polypeptide binding]; other site 1074252005183 ligand binding site [chemical binding]; other site 1074252005184 putative active site [active] 1074252005185 NAD(P) binding site [chemical binding]; other site 1074252005186 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1074252005187 Ligand Binding Site [chemical binding]; other site 1074252005188 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1074252005189 propionate/acetate kinase; Provisional; Region: PRK12379 1074252005190 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1074252005191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252005192 S-adenosylmethionine binding site [chemical binding]; other site 1074252005193 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1074252005194 dimer interface [polypeptide binding]; other site 1074252005195 catalytic triad [active] 1074252005196 peroxidatic and resolving cysteines [active] 1074252005197 hypothetical protein; Provisional; Region: PRK10621 1074252005198 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1074252005199 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1074252005200 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1074252005201 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1074252005202 Ligand Binding Site [chemical binding]; other site 1074252005203 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1074252005204 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1074252005205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1074252005206 catalytic residue [active] 1074252005207 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1074252005208 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1074252005209 GAF domain; Region: GAF_2; pfam13185 1074252005210 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1074252005211 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1074252005212 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1074252005213 RNA binding surface [nucleotide binding]; other site 1074252005214 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1074252005215 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1074252005216 active site 1074252005217 catalytic site [active] 1074252005218 OsmC-like protein; Region: OsmC; cl00767 1074252005219 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1074252005220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1074252005221 catalytic residue [active] 1074252005222 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1074252005223 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1074252005224 ligand binding site [chemical binding]; other site 1074252005225 NAD binding site [chemical binding]; other site 1074252005226 dimerization interface [polypeptide binding]; other site 1074252005227 catalytic site [active] 1074252005228 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1074252005229 putative L-serine binding site [chemical binding]; other site 1074252005230 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1074252005231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252005232 motif II; other site 1074252005233 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1074252005234 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1074252005235 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1074252005236 active site turn [active] 1074252005237 phosphorylation site [posttranslational modification] 1074252005238 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1074252005239 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1074252005240 putative acyl-acceptor binding pocket; other site 1074252005241 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1074252005242 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1074252005243 protein binding site [polypeptide binding]; other site 1074252005244 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1074252005245 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1074252005246 active site 1074252005247 HIGH motif; other site 1074252005248 dimer interface [polypeptide binding]; other site 1074252005249 KMSKS motif; other site 1074252005250 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1074252005251 RNA binding surface [nucleotide binding]; other site 1074252005252 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1074252005253 Transglycosylase; Region: Transgly; pfam00912 1074252005254 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 1074252005255 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1074252005256 NEAr Transporter domain; Region: NEAT; smart00725 1074252005257 NEAr Transporter domain; Region: NEAT; smart00725 1074252005258 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1074252005259 heme-binding site [chemical binding]; other site 1074252005260 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1074252005261 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1074252005262 Potassium binding sites [ion binding]; other site 1074252005263 Cesium cation binding sites [ion binding]; other site 1074252005264 acetyl-CoA synthetase; Provisional; Region: PRK04319 1074252005265 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1074252005266 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1074252005267 active site 1074252005268 acyl-activating enzyme (AAE) consensus motif; other site 1074252005269 putative CoA binding site [chemical binding]; other site 1074252005270 AMP binding site [chemical binding]; other site 1074252005271 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1074252005272 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1074252005273 active site 1074252005274 Zn binding site [ion binding]; other site 1074252005275 catabolite control protein A; Region: ccpA; TIGR01481 1074252005276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1074252005277 DNA binding site [nucleotide binding] 1074252005278 domain linker motif; other site 1074252005279 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1074252005280 dimerization interface [polypeptide binding]; other site 1074252005281 effector binding site; other site 1074252005282 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1074252005283 Chorismate mutase type II; Region: CM_2; cl00693 1074252005284 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1074252005285 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1074252005286 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1074252005287 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1074252005288 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1074252005289 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1074252005290 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1074252005291 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1074252005292 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1074252005293 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1074252005294 putative tRNA-binding site [nucleotide binding]; other site 1074252005295 hypothetical protein; Provisional; Region: PRK13668 1074252005296 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1074252005297 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1074252005298 catalytic residues [active] 1074252005299 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1074252005300 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1074252005301 oligomer interface [polypeptide binding]; other site 1074252005302 active site 1074252005303 metal binding site [ion binding]; metal-binding site 1074252005304 Predicted small secreted protein [Function unknown]; Region: COG5584 1074252005305 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1074252005306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252005307 S-adenosylmethionine binding site [chemical binding]; other site 1074252005308 Phosphotransferase enzyme family; Region: APH; pfam01636 1074252005309 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1074252005310 active site 1074252005311 substrate binding site [chemical binding]; other site 1074252005312 ATP binding site [chemical binding]; other site 1074252005313 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1074252005314 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1074252005315 homodimer interface [polypeptide binding]; other site 1074252005316 substrate-cofactor binding pocket; other site 1074252005317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252005318 catalytic residue [active] 1074252005319 dipeptidase PepV; Reviewed; Region: PRK07318 1074252005320 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1074252005321 active site 1074252005322 metal binding site [ion binding]; metal-binding site 1074252005323 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1074252005324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1074252005325 RNA binding surface [nucleotide binding]; other site 1074252005326 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1074252005327 active site 1074252005328 uracil binding [chemical binding]; other site 1074252005329 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1074252005330 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1074252005331 HI0933-like protein; Region: HI0933_like; pfam03486 1074252005332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1074252005333 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1074252005334 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1074252005335 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005336 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005337 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005338 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005339 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005340 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005341 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005342 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005343 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005344 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005345 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005346 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005347 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005348 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005349 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252005350 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1074252005351 active site residue [active] 1074252005352 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1074252005353 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1074252005354 HIGH motif; other site 1074252005355 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1074252005356 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1074252005357 active site 1074252005358 KMSKS motif; other site 1074252005359 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1074252005360 tRNA binding surface [nucleotide binding]; other site 1074252005361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252005362 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252005363 putative substrate translocation pore; other site 1074252005364 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1074252005365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252005366 S-adenosylmethionine binding site [chemical binding]; other site 1074252005367 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252005368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1074252005369 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1074252005370 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1074252005371 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1074252005372 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1074252005373 homopentamer interface [polypeptide binding]; other site 1074252005374 active site 1074252005375 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1074252005376 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1074252005377 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1074252005378 dimerization interface [polypeptide binding]; other site 1074252005379 active site 1074252005380 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1074252005381 Lumazine binding domain; Region: Lum_binding; pfam00677 1074252005382 Lumazine binding domain; Region: Lum_binding; pfam00677 1074252005383 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1074252005384 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1074252005385 catalytic motif [active] 1074252005386 Zn binding site [ion binding]; other site 1074252005387 RibD C-terminal domain; Region: RibD_C; cl17279 1074252005388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1074252005389 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1074252005390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1074252005391 dimerization interface [polypeptide binding]; other site 1074252005392 putative DNA binding site [nucleotide binding]; other site 1074252005393 putative Zn2+ binding site [ion binding]; other site 1074252005394 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1074252005395 arsenical pump membrane protein; Provisional; Region: PRK15445 1074252005396 transmembrane helices; other site 1074252005397 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1074252005398 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1074252005399 active site 1074252005400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252005401 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252005402 putative substrate translocation pore; other site 1074252005404 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1074252005405 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1074252005406 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1074252005407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1074252005408 DNA binding residues [nucleotide binding] 1074252005409 CAAX protease self-immunity; Region: Abi; pfam02517 1074252005410 CAAX protease self-immunity; Region: Abi; pfam02517 1074252005411 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1074252005412 active site 1074252005413 intersubunit interactions; other site 1074252005414 catalytic residue [active] 1074252005415 camphor resistance protein CrcB; Provisional; Region: PRK14201 1074252005416 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1074252005418 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1074252005419 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1074252005420 active site 1074252005421 catalytic tetrad [active] 1074252005422 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1074252005423 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1074252005424 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1074252005425 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1074252005426 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1074252005427 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1074252005428 active site 1074252005429 substrate-binding site [chemical binding]; other site 1074252005430 metal-binding site [ion binding] 1074252005431 ATP binding site [chemical binding]; other site 1074252005432 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1074252005433 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1074252005434 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1074252005435 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1074252005436 nudix motif; other site 1074252005437 Haemolytic domain; Region: Haemolytic; pfam01809 1074252005438 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1074252005439 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1074252005440 metal binding site [ion binding]; metal-binding site 1074252005441 substrate binding pocket [chemical binding]; other site 1074252005442 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1074252005443 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1074252005444 acyl-activating enzyme (AAE) consensus motif; other site 1074252005445 putative AMP binding site [chemical binding]; other site 1074252005446 putative active site [active] 1074252005447 putative CoA binding site [chemical binding]; other site 1074252005449 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1074252005450 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1074252005451 transposase/IS protein; Provisional; Region: PRK09183 1074252005452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252005453 Walker A motif; other site 1074252005454 ATP binding site [chemical binding]; other site 1074252005455 Walker B motif; other site 1074252005456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1074252005457 Integrase core domain; Region: rve; pfam00665 1074252005458 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1074252005461 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1074252005462 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1074252005463 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1074252005464 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1074252005465 DNA protecting protein DprA; Region: dprA; TIGR00732 1074252005467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1074252005468 Transposase; Region: HTH_Tnp_1; pfam01527 1074252005469 putative transposase OrfB; Reviewed; Region: PHA02517 1074252005470 HTH-like domain; Region: HTH_21; pfam13276 1074252005471 Integrase core domain; Region: rve; pfam00665 1074252005472 Integrase core domain; Region: rve_3; pfam13683 1074252005474 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1074252005475 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252005476 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1074252005477 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252005478 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1074252005479 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252005480 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1074252005481 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252005482 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1074252005483 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252005484 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1074252005485 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1074252005486 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1074252005487 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1074252005488 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1074252005489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1074252005490 ferrochelatase; Provisional; Region: PRK12435 1074252005491 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1074252005492 C-terminal domain interface [polypeptide binding]; other site 1074252005493 active site 1074252005494 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1074252005495 active site 1074252005496 N-terminal domain interface [polypeptide binding]; other site 1074252005497 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1074252005498 substrate binding site [chemical binding]; other site 1074252005499 active site 1074252005500 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1074252005501 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1074252005502 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1074252005503 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1074252005504 Walker A/P-loop; other site 1074252005505 ATP binding site [chemical binding]; other site 1074252005506 Q-loop/lid; other site 1074252005507 ABC transporter signature motif; other site 1074252005508 Walker B; other site 1074252005509 D-loop; other site 1074252005510 H-loop/switch region; other site 1074252005511 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1074252005512 HIT family signature motif; other site 1074252005513 catalytic residue [active] 1074252005514 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1074252005515 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1074252005516 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1074252005517 SurA N-terminal domain; Region: SurA_N_3; cl07813 1074252005518 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1074252005519 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1074252005520 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1074252005521 generic binding surface II; other site 1074252005522 generic binding surface I; other site 1074252005523 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1074252005524 Zn2+ binding site [ion binding]; other site 1074252005525 Mg2+ binding site [ion binding]; other site 1074252005526 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1074252005527 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1074252005528 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 1074252005529 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1074252005530 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1074252005531 active site 1074252005532 metal binding site [ion binding]; metal-binding site 1074252005533 DNA binding site [nucleotide binding] 1074252005534 hypothetical protein; Provisional; Region: PRK13676 1074252005535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1074252005536 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1074252005537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1074252005538 non-specific DNA binding site [nucleotide binding]; other site 1074252005539 salt bridge; other site 1074252005540 sequence-specific DNA binding site [nucleotide binding]; other site 1074252005541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1074252005542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252005543 active site 1074252005544 phosphorylation site [posttranslational modification] 1074252005545 intermolecular recognition site; other site 1074252005546 dimerization interface [polypeptide binding]; other site 1074252005547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1074252005548 DNA binding residues [nucleotide binding] 1074252005549 dimerization interface [polypeptide binding]; other site 1074252005550 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1074252005551 GAF domain; Region: GAF_3; pfam13492 1074252005552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1074252005553 Histidine kinase; Region: HisKA_3; pfam07730 1074252005554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252005555 ATP binding site [chemical binding]; other site 1074252005556 Mg2+ binding site [ion binding]; other site 1074252005557 G-X-G motif; other site 1074252005558 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1074252005559 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1074252005560 active site 1074252005561 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1074252005562 Class II fumarases; Region: Fumarase_classII; cd01362 1074252005563 active site 1074252005564 tetramer interface [polypeptide binding]; other site 1074252005565 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1074252005566 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1074252005567 active site 1074252005568 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1074252005569 epoxyqueuosine reductase; Region: TIGR00276 1074252005570 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1074252005571 HEAT repeats; Region: HEAT_2; pfam13646 1074252005572 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1074252005573 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1074252005574 Walker A/P-loop; other site 1074252005575 ATP binding site [chemical binding]; other site 1074252005576 Q-loop/lid; other site 1074252005577 ABC transporter signature motif; other site 1074252005578 Walker B; other site 1074252005579 D-loop; other site 1074252005580 H-loop/switch region; other site 1074252005581 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1074252005582 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1074252005583 substrate binding pocket [chemical binding]; other site 1074252005584 membrane-bound complex binding site; other site 1074252005585 hinge residues; other site 1074252005586 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1074252005587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252005588 dimer interface [polypeptide binding]; other site 1074252005589 conserved gate region; other site 1074252005590 putative PBP binding loops; other site 1074252005591 ABC-ATPase subunit interface; other site 1074252005592 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1074252005593 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1074252005594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1074252005595 Transposase; Region: HTH_Tnp_1; pfam01527 1074252005596 putative transposase OrfB; Reviewed; Region: PHA02517 1074252005597 HTH-like domain; Region: HTH_21; pfam13276 1074252005598 Integrase core domain; Region: rve; pfam00665 1074252005599 Integrase core domain; Region: rve_3; pfam13683 1074252005600 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1074252005601 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1074252005602 metal binding site 2 [ion binding]; metal-binding site 1074252005603 putative DNA binding helix; other site 1074252005604 metal binding site 1 [ion binding]; metal-binding site 1074252005605 dimer interface [polypeptide binding]; other site 1074252005606 structural Zn2+ binding site [ion binding]; other site 1074252005607 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1074252005608 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1074252005609 putative ligand binding site [chemical binding]; other site 1074252005610 NAD binding site [chemical binding]; other site 1074252005611 catalytic site [active] 1074252005612 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1074252005613 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1074252005614 catalytic triad [active] 1074252005615 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1074252005616 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1074252005617 inhibitor-cofactor binding pocket; inhibition site 1074252005618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252005619 catalytic residue [active] 1074252005620 Predicted membrane protein [Function unknown]; Region: COG4129 1074252005621 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1074252005622 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1074252005623 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1074252005624 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1074252005625 Walker A/P-loop; other site 1074252005626 ATP binding site [chemical binding]; other site 1074252005627 Q-loop/lid; other site 1074252005628 ABC transporter signature motif; other site 1074252005629 Walker B; other site 1074252005630 D-loop; other site 1074252005631 H-loop/switch region; other site 1074252005632 hypothetical protein; Provisional; Region: PRK13662 1074252005633 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1074252005634 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1074252005635 minor groove reading motif; other site 1074252005636 helix-hairpin-helix signature motif; other site 1074252005637 substrate binding pocket [chemical binding]; other site 1074252005638 active site 1074252005639 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1074252005640 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1074252005641 DNA binding and oxoG recognition site [nucleotide binding] 1074252005642 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1074252005643 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1074252005644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1074252005645 Walker A/P-loop; other site 1074252005646 ATP binding site [chemical binding]; other site 1074252005647 Q-loop/lid; other site 1074252005648 ABC transporter signature motif; other site 1074252005649 Walker B; other site 1074252005650 H-loop/switch region; other site 1074252005651 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1074252005652 recombination regulator RecX; Provisional; Region: recX; PRK14135 1074252005653 glycosyltransferase; Provisional; Region: PRK13481 1074252005654 Transglycosylase; Region: Transgly; pfam00912 1074252005655 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1074252005656 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1074252005657 proposed catalytic triad [active] 1074252005658 conserved cys residue [active] 1074252005659 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1074252005660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1074252005661 FeS/SAM binding site; other site 1074252005662 YfkB-like domain; Region: YfkB; pfam08756 1074252005663 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1074252005664 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1074252005665 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1074252005666 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1074252005667 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1074252005668 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1074252005669 active site 1074252005670 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1074252005671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1074252005672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252005673 active site 1074252005674 phosphorylation site [posttranslational modification] 1074252005675 intermolecular recognition site; other site 1074252005676 dimerization interface [polypeptide binding]; other site 1074252005677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1074252005678 DNA binding residues [nucleotide binding] 1074252005679 dimerization interface [polypeptide binding]; other site 1074252005680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1074252005681 Histidine kinase; Region: HisKA_3; pfam07730 1074252005682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252005683 ATP binding site [chemical binding]; other site 1074252005684 Mg2+ binding site [ion binding]; other site 1074252005685 G-X-G motif; other site 1074252005686 Predicted membrane protein [Function unknown]; Region: COG4758 1074252005687 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1074252005688 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1074252005689 active site 1074252005690 Predicted membrane protein [Function unknown]; Region: COG4129 1074252005691 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1074252005692 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1074252005693 catalytic triad [active] 1074252005694 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1074252005695 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1074252005696 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1074252005697 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1074252005698 Ferritin-like domain; Region: Ferritin; pfam00210 1074252005699 ferroxidase diiron center [ion binding]; other site 1074252005700 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1074252005701 active site 1074252005702 catalytic site [active] 1074252005703 substrate binding site [chemical binding]; other site 1074252005704 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1074252005705 active site 1074252005706 DNA polymerase IV; Validated; Region: PRK02406 1074252005707 DNA binding site [nucleotide binding] 1074252005708 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1074252005709 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1074252005710 TRAM domain; Region: TRAM; cl01282 1074252005711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252005712 S-adenosylmethionine binding site [chemical binding]; other site 1074252005713 putative lipid kinase; Reviewed; Region: PRK13337 1074252005714 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1074252005715 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1074252005716 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1074252005717 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1074252005718 GatB domain; Region: GatB_Yqey; pfam02637 1074252005719 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1074252005720 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1074252005721 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1074252005722 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1074252005723 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1074252005724 Na binding site [ion binding]; other site 1074252005725 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1074252005726 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1074252005727 putative dimer interface [polypeptide binding]; other site 1074252005728 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1074252005729 putative dimer interface [polypeptide binding]; other site 1074252005730 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1074252005731 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1074252005732 nucleotide binding pocket [chemical binding]; other site 1074252005733 K-X-D-G motif; other site 1074252005734 catalytic site [active] 1074252005735 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1074252005736 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1074252005737 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1074252005738 Dimer interface [polypeptide binding]; other site 1074252005739 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1074252005740 Part of AAA domain; Region: AAA_19; pfam13245 1074252005741 Family description; Region: UvrD_C_2; pfam13538 1074252005742 PcrB family; Region: PcrB; pfam01884 1074252005743 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1074252005744 substrate binding site [chemical binding]; other site 1074252005745 putative active site [active] 1074252005746 dimer interface [polypeptide binding]; other site 1074252005747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1074252005748 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1074252005749 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1074252005750 tetramer interface [polypeptide binding]; other site 1074252005751 active site 1074252005752 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1074252005753 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1074252005754 Staphostatin A; Region: Staphostatin_A; pfam09022 1074252005757 NETI protein; Region: NETI; pfam14044 1074252005758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1074252005759 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1074252005760 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1074252005761 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1074252005762 homodimer interface [polypeptide binding]; other site 1074252005763 NAD binding pocket [chemical binding]; other site 1074252005764 ATP binding pocket [chemical binding]; other site 1074252005765 Mg binding site [ion binding]; other site 1074252005766 active-site loop [active] 1074252005767 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1074252005768 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1074252005769 active site 1074252005770 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1074252005771 active site 1074252005772 dimer interface [polypeptide binding]; other site 1074252005773 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1074252005774 Prephenate dehydratase; Region: PDT; pfam00800 1074252005775 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1074252005776 putative L-Phe binding site [chemical binding]; other site 1074252005777 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1074252005778 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1074252005779 transmembrane helices; other site 1074252005780 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1074252005781 Isochorismatase family; Region: Isochorismatase; pfam00857 1074252005782 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1074252005783 catalytic triad [active] 1074252005784 conserved cis-peptide bond; other site 1074252005785 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1074252005786 DHH family; Region: DHH; pfam01368 1074252005787 DHHA2 domain; Region: DHHA2; pfam02833 1074252005788 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1074252005789 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1074252005790 NAD(P) binding site [chemical binding]; other site 1074252005791 catalytic residues [active] 1074252005792 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1074252005794 Predicted transcriptional regulator [Transcription]; Region: COG3682 1074252005795 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1074252005796 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1074252005797 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1074252005798 YolD-like protein; Region: YolD; pfam08863 1074252005799 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1074252005800 integron integrase; Region: integrase_gron; TIGR02249 1074252005801 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 1074252005802 Int/Topo IB signature motif; other site 1074252005803 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1074252005804 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1074252005805 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 1074252005806 Int/Topo IB signature motif; other site 1074252005807 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1074252005808 active site 1074252005809 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1074252005810 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1074252005811 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1074252005812 Bacterial PH domain; Region: DUF304; cl01348 1074252005813 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 1074252005814 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1074252005815 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1074252005816 Walker A/P-loop; other site 1074252005817 ATP binding site [chemical binding]; other site 1074252005818 Q-loop/lid; other site 1074252005819 ABC transporter signature motif; other site 1074252005820 Walker B; other site 1074252005821 D-loop; other site 1074252005822 H-loop/switch region; other site 1074252005823 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1074252005824 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1074252005825 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1074252005826 Walker A/P-loop; other site 1074252005827 ATP binding site [chemical binding]; other site 1074252005828 Q-loop/lid; other site 1074252005829 ABC transporter signature motif; other site 1074252005830 Walker B; other site 1074252005831 D-loop; other site 1074252005832 H-loop/switch region; other site 1074252005833 Predicted transcriptional regulators [Transcription]; Region: COG1725 1074252005834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1074252005835 DNA-binding site [nucleotide binding]; DNA binding site 1074252005836 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1074252005837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1074252005838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252005839 homodimer interface [polypeptide binding]; other site 1074252005840 catalytic residue [active] 1074252005841 MAP domain; Region: MAP; pfam03642 1074252005842 MAP domain; Region: MAP; pfam03642 1074252005843 MAP domain; Region: MAP; pfam03642 1074252005844 MAP domain; Region: MAP; pfam03642 1074252005845 MAP domain; Region: MAP; pfam03642 1074252005846 MAP domain; Region: MAP; pfam03642 1074252005848 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1074252005849 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 1074252005851 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 1074252005852 CHAP domain; Region: CHAP; pfam05257 1074252005853 Small integral membrane protein [Function unknown]; Region: COG5546 1074252005854 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 1074252005855 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 1074252005856 TolA protein; Region: tolA_full; TIGR02794 1074252005857 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1074252005858 Phage tail protein; Region: Sipho_tail; cl17486 1074252005859 Phage tail protein; Region: Sipho_tail; cl17486 1074252005860 Phage-related minor tail protein [Function unknown]; Region: COG5280 1074252005861 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1074252005862 Phage-related protein [Function unknown]; Region: COG5412 1074252005863 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 1074252005864 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1074252005865 Peptidase family M23; Region: Peptidase_M23; pfam01551 1074252005866 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1074252005867 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1074252005868 catalytic residue [active] 1074252005871 Phage capsid family; Region: Phage_capsid; pfam05065 1074252005872 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1074252005873 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1074252005874 oligomer interface [polypeptide binding]; other site 1074252005875 active site residues [active] 1074252005876 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1074252005877 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1074252005878 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1074252005879 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1074252005880 HNH endonuclease; Region: HNH; pfam01844 1074252005881 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1074252005882 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1074252005883 Transcriptional activator RinB; Region: RinB; pfam06116 1074252005884 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 1074252005885 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1074252005886 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1074252005887 trimer interface [polypeptide binding]; other site 1074252005888 active site 1074252005889 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1074252005890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1074252005891 Transposase; Region: HTH_Tnp_1; pfam01527 1074252005892 putative transposase OrfB; Reviewed; Region: PHA02517 1074252005893 HTH-like domain; Region: HTH_21; pfam13276 1074252005894 Integrase core domain; Region: rve; pfam00665 1074252005895 Integrase core domain; Region: rve_3; pfam13683 1074252005896 YopX protein; Region: YopX; pfam09643 1074252005897 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1074252005898 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1074252005899 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1074252005900 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1074252005901 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1074252005902 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1074252005903 dimer interface [polypeptide binding]; other site 1074252005904 ssDNA binding site [nucleotide binding]; other site 1074252005905 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1074252005906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1074252005907 RecT family; Region: RecT; pfam03837 1074252005908 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1074252005909 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1074252005910 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 1074252005911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 1074252005912 AntA/AntB antirepressor; Region: AntA; cl01430 1074252005913 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1074252005914 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1074252005915 Protein of unknown function (DUF739); Region: DUF739; pfam05339 1074252005916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1074252005917 non-specific DNA binding site [nucleotide binding]; other site 1074252005918 salt bridge; other site 1074252005919 sequence-specific DNA binding site [nucleotide binding]; other site 1074252005920 Predicted transcriptional regulator [Transcription]; Region: COG2932 1074252005921 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1074252005922 Catalytic site [active] 1074252005923 HIRAN domain; Region: HIRAN; pfam08797 1074252005924 PemK-like protein; Region: PemK; pfam02452 1074252005925 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1074252005926 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1074252005927 Int/Topo IB signature motif; other site 1074252005928 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1074252005929 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1074252005930 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1074252005931 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1074252005932 metal binding site [ion binding]; metal-binding site 1074252005933 dimer interface [polypeptide binding]; other site 1074252005934 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1074252005935 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1074252005936 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1074252005937 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1074252005938 putative ligand binding residues [chemical binding]; other site 1074252005939 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1074252005940 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1074252005941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252005942 Coenzyme A binding pocket [chemical binding]; other site 1074252005943 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1074252005944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1074252005945 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1074252005946 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1074252005947 ring oligomerisation interface [polypeptide binding]; other site 1074252005948 ATP/Mg binding site [chemical binding]; other site 1074252005949 stacking interactions; other site 1074252005950 hinge regions; other site 1074252005951 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1074252005952 oligomerisation interface [polypeptide binding]; other site 1074252005953 mobile loop; other site 1074252005954 roof hairpin; other site 1074252005955 CAAX protease self-immunity; Region: Abi; pfam02517 1074252005956 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1074252005957 dimer interface [polypeptide binding]; other site 1074252005958 FMN binding site [chemical binding]; other site 1074252005959 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1074252005960 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1074252005961 putative active site [active] 1074252005962 catalytic triad [active] 1074252005963 putative dimer interface [polypeptide binding]; other site 1074252005964 delta-hemolysin; Provisional; Region: PRK14752 1074252005965 Accessory gene regulator B; Region: AgrB; smart00793 1074252005966 Staphylococcal AgrD protein; Region: AgrD; smart00794 1074252005967 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1074252005968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252005969 Mg2+ binding site [ion binding]; other site 1074252005970 G-X-G motif; other site 1074252005971 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1074252005972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252005973 active site 1074252005974 phosphorylation site [posttranslational modification] 1074252005975 intermolecular recognition site; other site 1074252005976 dimerization interface [polypeptide binding]; other site 1074252005977 LytTr DNA-binding domain; Region: LytTR; pfam04397 1074252005978 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1074252005979 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1074252005980 putative substrate binding site [chemical binding]; other site 1074252005981 putative ATP binding site [chemical binding]; other site 1074252005982 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1074252005983 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1074252005984 substrate binding [chemical binding]; other site 1074252005985 active site 1074252005986 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1074252005987 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1074252005988 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1074252005989 DNA binding site [nucleotide binding] 1074252005990 domain linker motif; other site 1074252005991 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1074252005992 dimerization interface [polypeptide binding]; other site 1074252005993 ligand binding site [chemical binding]; other site 1074252005994 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1074252005995 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1074252005996 CPxP motif; other site 1074252005997 Predicted transporter component [General function prediction only]; Region: COG2391 1074252005998 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1074252005999 Sulphur transport; Region: Sulf_transp; pfam04143 1074252006000 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1074252006001 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1074252006002 CoA binding domain; Region: CoA_binding; pfam02629 1074252006003 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1074252006004 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1074252006005 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1074252006006 ABC transporter; Region: ABC_tran_2; pfam12848 1074252006007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1074252006008 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 1074252006009 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 1074252006010 Walker A/P-loop; other site 1074252006011 ATP binding site [chemical binding]; other site 1074252006012 Q-loop/lid; other site 1074252006013 ABC transporter signature motif; other site 1074252006014 Walker B; other site 1074252006015 D-loop; other site 1074252006016 H-loop/switch region; other site 1074252006017 UGMP family protein; Validated; Region: PRK09604 1074252006018 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1074252006019 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1074252006020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252006021 Coenzyme A binding pocket [chemical binding]; other site 1074252006022 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1074252006023 Glycoprotease family; Region: Peptidase_M22; pfam00814 1074252006024 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1074252006025 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1074252006026 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1074252006027 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1074252006028 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1074252006029 PYR/PP interface [polypeptide binding]; other site 1074252006030 dimer interface [polypeptide binding]; other site 1074252006031 TPP binding site [chemical binding]; other site 1074252006032 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1074252006033 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1074252006034 TPP-binding site [chemical binding]; other site 1074252006035 dimer interface [polypeptide binding]; other site 1074252006037 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1074252006038 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1074252006039 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1074252006040 2-isopropylmalate synthase; Validated; Region: PRK00915 1074252006041 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1074252006042 active site 1074252006043 catalytic residues [active] 1074252006044 metal binding site [ion binding]; metal-binding site 1074252006045 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1074252006046 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1074252006047 tartrate dehydrogenase; Region: TTC; TIGR02089 1074252006048 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1074252006049 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1074252006050 substrate binding site [chemical binding]; other site 1074252006051 ligand binding site [chemical binding]; other site 1074252006052 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1074252006053 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1074252006054 substrate binding site [chemical binding]; other site 1074252006055 threonine dehydratase; Validated; Region: PRK08639 1074252006056 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1074252006057 tetramer interface [polypeptide binding]; other site 1074252006058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252006059 catalytic residue [active] 1074252006060 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1074252006061 Winged helix-turn helix; Region: HTH_29; pfam13551 1074252006062 Integrase core domain; Region: rve; pfam00665 1074252006063 transposase/IS protein; Provisional; Region: PRK09183 1074252006064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252006065 Walker A motif; other site 1074252006066 ATP binding site [chemical binding]; other site 1074252006067 Walker B motif; other site 1074252006068 arginine finger; other site 1074252006069 hypothetical protein; Provisional; Region: PRK04351 1074252006070 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1074252006071 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1074252006072 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1074252006073 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1074252006074 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1074252006075 RNA binding site [nucleotide binding]; other site 1074252006076 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1074252006077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1074252006078 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1074252006079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1074252006080 DNA binding residues [nucleotide binding] 1074252006081 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1074252006082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252006083 ATP binding site [chemical binding]; other site 1074252006084 Mg2+ binding site [ion binding]; other site 1074252006085 G-X-G motif; other site 1074252006086 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1074252006087 anti sigma factor interaction site; other site 1074252006088 regulatory phosphorylation site [posttranslational modification]; other site 1074252006089 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1074252006090 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1074252006091 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1074252006092 PemK-like protein; Region: PemK; pfam02452 1074252006093 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1074252006094 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1074252006095 active site 1074252006096 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1074252006097 dimer interface [polypeptide binding]; other site 1074252006098 substrate binding site [chemical binding]; other site 1074252006099 catalytic residues [active] 1074252006100 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1074252006101 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1074252006102 Predicted membrane protein [Function unknown]; Region: COG3428 1074252006103 Bacterial PH domain; Region: DUF304; pfam03703 1074252006104 Bacterial PH domain; Region: DUF304; pfam03703 1074252006105 Bacterial PH domain; Region: DUF304; cl01348 1074252006106 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1074252006107 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 1074252006108 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1074252006109 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1074252006110 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1074252006111 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1074252006112 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1074252006113 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1074252006114 Ligand Binding Site [chemical binding]; other site 1074252006115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1074252006116 dimer interface [polypeptide binding]; other site 1074252006117 phosphorylation site [posttranslational modification] 1074252006118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252006119 ATP binding site [chemical binding]; other site 1074252006120 Mg2+ binding site [ion binding]; other site 1074252006121 G-X-G motif; other site 1074252006122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1074252006123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252006124 active site 1074252006125 phosphorylation site [posttranslational modification] 1074252006126 intermolecular recognition site; other site 1074252006127 dimerization interface [polypeptide binding]; other site 1074252006128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1074252006129 DNA binding site [nucleotide binding] 1074252006130 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1074252006131 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1074252006132 ATP binding site [chemical binding]; other site 1074252006133 Mg++ binding site [ion binding]; other site 1074252006134 motif III; other site 1074252006135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1074252006136 nucleotide binding region [chemical binding]; other site 1074252006137 ATP-binding site [chemical binding]; other site 1074252006138 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1074252006139 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1074252006140 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1074252006141 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1074252006142 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1074252006143 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1074252006144 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1074252006145 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1074252006146 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1074252006147 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1074252006148 putative homodimer interface [polypeptide binding]; other site 1074252006149 putative homotetramer interface [polypeptide binding]; other site 1074252006150 allosteric switch controlling residues; other site 1074252006151 putative metal binding site [ion binding]; other site 1074252006152 putative homodimer-homodimer interface [polypeptide binding]; other site 1074252006153 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1074252006154 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1074252006155 putative active site [active] 1074252006156 catalytic site [active] 1074252006157 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1074252006158 putative active site [active] 1074252006159 catalytic site [active] 1074252006160 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1074252006161 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1074252006162 Zn2+ binding site [ion binding]; other site 1074252006163 Mg2+ binding site [ion binding]; other site 1074252006164 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1074252006165 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1074252006166 thiamine phosphate binding site [chemical binding]; other site 1074252006167 active site 1074252006168 pyrophosphate binding site [ion binding]; other site 1074252006169 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1074252006170 substrate binding site [chemical binding]; other site 1074252006171 multimerization interface [polypeptide binding]; other site 1074252006172 ATP binding site [chemical binding]; other site 1074252006173 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1074252006174 dimer interface [polypeptide binding]; other site 1074252006175 substrate binding site [chemical binding]; other site 1074252006176 ATP binding site [chemical binding]; other site 1074252006177 thiaminase II; Region: salvage_TenA; TIGR04306 1074252006178 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1074252006179 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1074252006180 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1074252006181 dimer interface [polypeptide binding]; other site 1074252006182 ssDNA binding site [nucleotide binding]; other site 1074252006183 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1074252006184 YwpF-like protein; Region: YwpF; pfam14183 1074252006185 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1074252006186 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1074252006187 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1074252006188 hinge; other site 1074252006189 active site 1074252006190 Predicted membrane protein [Function unknown]; Region: COG4836 1074252006191 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 1074252006192 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1074252006193 gamma subunit interface [polypeptide binding]; other site 1074252006194 epsilon subunit interface [polypeptide binding]; other site 1074252006195 LBP interface [polypeptide binding]; other site 1074252006196 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1074252006197 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1074252006198 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1074252006199 alpha subunit interaction interface [polypeptide binding]; other site 1074252006200 Walker A motif; other site 1074252006201 ATP binding site [chemical binding]; other site 1074252006202 Walker B motif; other site 1074252006203 inhibitor binding site; inhibition site 1074252006204 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1074252006205 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1074252006206 core domain interface [polypeptide binding]; other site 1074252006207 delta subunit interface [polypeptide binding]; other site 1074252006208 epsilon subunit interface [polypeptide binding]; other site 1074252006209 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1074252006210 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1074252006211 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1074252006212 beta subunit interaction interface [polypeptide binding]; other site 1074252006213 Walker A motif; other site 1074252006214 ATP binding site [chemical binding]; other site 1074252006215 Walker B motif; other site 1074252006216 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1074252006217 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1074252006218 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1074252006219 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1074252006220 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1074252006221 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1074252006222 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1074252006223 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1074252006224 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1074252006225 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1074252006226 active site 1074252006227 homodimer interface [polypeptide binding]; other site 1074252006228 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1074252006229 active site 1074252006230 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1074252006231 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1074252006232 dimer interface [polypeptide binding]; other site 1074252006233 active site 1074252006234 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1074252006235 folate binding site [chemical binding]; other site 1074252006236 hypothetical protein; Provisional; Region: PRK13690 1074252006237 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1074252006238 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1074252006239 active site 1074252006240 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1074252006241 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1074252006242 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1074252006243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252006244 S-adenosylmethionine binding site [chemical binding]; other site 1074252006245 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1074252006246 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1074252006247 RF-1 domain; Region: RF-1; pfam00472 1074252006248 thymidine kinase; Provisional; Region: PRK04296 1074252006249 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1074252006250 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1074252006251 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1074252006252 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1074252006253 RNA binding site [nucleotide binding]; other site 1074252006254 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1074252006255 multimer interface [polypeptide binding]; other site 1074252006256 Walker A motif; other site 1074252006257 ATP binding site [chemical binding]; other site 1074252006258 Walker B motif; other site 1074252006259 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1074252006260 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1074252006261 NAD binding site [chemical binding]; other site 1074252006262 catalytic residues [active] 1074252006263 Predicted transcriptional regulators [Transcription]; Region: COG1733 1074252006264 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1074252006265 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1074252006266 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1074252006267 hinge; other site 1074252006268 active site 1074252006269 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1074252006270 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1074252006271 intersubunit interface [polypeptide binding]; other site 1074252006272 active site 1074252006273 zinc binding site [ion binding]; other site 1074252006274 Na+ binding site [ion binding]; other site 1074252006275 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1074252006276 CTP synthetase; Validated; Region: pyrG; PRK05380 1074252006277 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1074252006278 Catalytic site [active] 1074252006279 active site 1074252006280 UTP binding site [chemical binding]; other site 1074252006281 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1074252006282 active site 1074252006283 putative oxyanion hole; other site 1074252006284 catalytic triad [active] 1074252006285 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1074252006286 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1074252006287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252006288 Coenzyme A binding pocket [chemical binding]; other site 1074252006289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1074252006290 Coenzyme A binding pocket [chemical binding]; other site 1074252006291 pantothenate kinase; Provisional; Region: PRK13317 1074252006292 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1074252006293 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1074252006294 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1074252006295 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1074252006296 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1074252006297 metal binding site [ion binding]; metal-binding site 1074252006298 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1074252006299 Predicted membrane protein [Function unknown]; Region: COG4270 1074252006300 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1074252006301 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1074252006302 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1074252006303 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1074252006304 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1074252006305 intersubunit interface [polypeptide binding]; other site 1074252006306 active site 1074252006307 catalytic residue [active] 1074252006308 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1074252006309 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1074252006310 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1074252006311 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1074252006312 dimerization interface [polypeptide binding]; other site 1074252006313 DPS ferroxidase diiron center [ion binding]; other site 1074252006314 ion pore; other site 1074252006315 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1074252006316 EVE domain; Region: EVE; cl00728 1074252006317 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1074252006318 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1074252006319 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1074252006320 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1074252006321 NAD(P) binding site [chemical binding]; other site 1074252006322 putative active site [active] 1074252006323 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1074252006324 dimerization interface [polypeptide binding]; other site 1074252006325 putative DNA binding site [nucleotide binding]; other site 1074252006326 putative Zn2+ binding site [ion binding]; other site 1074252006327 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1074252006328 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1074252006330 Syndecan domain; Region: Syndecan; pfam01034 1074252006331 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1074252006332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252006333 active site 1074252006334 motif I; other site 1074252006335 motif II; other site 1074252006336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252006337 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1074252006338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1074252006339 Walker A/P-loop; other site 1074252006340 ATP binding site [chemical binding]; other site 1074252006341 Q-loop/lid; other site 1074252006342 ABC transporter signature motif; other site 1074252006343 Walker B; other site 1074252006344 D-loop; other site 1074252006345 H-loop/switch region; other site 1074252006346 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1074252006347 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1074252006348 glutaminase active site [active] 1074252006349 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1074252006350 dimer interface [polypeptide binding]; other site 1074252006351 active site 1074252006352 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1074252006353 dimer interface [polypeptide binding]; other site 1074252006354 active site 1074252006355 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1074252006356 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1074252006357 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1074252006358 active site 1074252006359 P-loop; other site 1074252006360 phosphorylation site [posttranslational modification] 1074252006361 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1074252006362 HTH domain; Region: HTH_11; pfam08279 1074252006363 Mga helix-turn-helix domain; Region: Mga; pfam05043 1074252006364 PRD domain; Region: PRD; pfam00874 1074252006365 PRD domain; Region: PRD; pfam00874 1074252006366 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1074252006367 active site 1074252006368 P-loop; other site 1074252006369 phosphorylation site [posttranslational modification] 1074252006370 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1074252006371 active site 1074252006372 phosphorylation site [posttranslational modification] 1074252006373 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1074252006374 active site 1074252006375 phosphorylation site [posttranslational modification] 1074252006376 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1074252006377 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1074252006378 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1074252006379 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1074252006380 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1074252006381 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252006382 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252006383 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252006384 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252006385 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252006386 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252006387 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252006388 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252006389 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1074252006390 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1074252006391 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1074252006392 active site 1074252006393 substrate binding site [chemical binding]; other site 1074252006394 metal binding site [ion binding]; metal-binding site 1074252006395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1074252006396 YbbR-like protein; Region: YbbR; pfam07949 1074252006397 TIGR00159 family protein; Region: TIGR00159 1074252006398 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1074252006399 Arginase family; Region: Arginase; cd09989 1074252006400 active site 1074252006401 Mn binding site [ion binding]; other site 1074252006402 oligomer interface [polypeptide binding]; other site 1074252006403 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1074252006404 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1074252006405 Walker A motif; other site 1074252006406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252006407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252006408 putative substrate translocation pore; other site 1074252006409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252006410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252006411 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1074252006412 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1074252006413 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1074252006414 substrate binding site; other site 1074252006415 dimerization interface; other site 1074252006416 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1074252006417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1074252006418 Nucleoside recognition; Region: Gate; pfam07670 1074252006419 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1074252006420 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252006421 ABC-ATPase subunit interface; other site 1074252006422 dimer interface [polypeptide binding]; other site 1074252006423 putative PBP binding regions; other site 1074252006424 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1074252006425 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1074252006426 ABC-ATPase subunit interface; other site 1074252006427 dimer interface [polypeptide binding]; other site 1074252006428 putative PBP binding regions; other site 1074252006429 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1074252006430 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1074252006431 siderophore binding site; other site 1074252006432 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1074252006433 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1074252006434 dimer interface [polypeptide binding]; other site 1074252006435 active site 1074252006436 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1074252006437 substrate binding site [chemical binding]; other site 1074252006438 catalytic residue [active] 1074252006439 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1074252006440 IucA / IucC family; Region: IucA_IucC; pfam04183 1074252006441 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1074252006442 H+ Antiporter protein; Region: 2A0121; TIGR00900 1074252006443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252006444 putative substrate translocation pore; other site 1074252006445 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1074252006446 IucA / IucC family; Region: IucA_IucC; pfam04183 1074252006447 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1074252006448 Asp23 family; Region: Asp23; pfam03780 1074252006449 Small integral membrane protein [Function unknown]; Region: COG5547 1074252006450 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1074252006451 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1074252006452 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1074252006453 putative NAD(P) binding site [chemical binding]; other site 1074252006454 dimer interface [polypeptide binding]; other site 1074252006455 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1074252006456 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1074252006457 NAD(P) binding site [chemical binding]; other site 1074252006458 substrate binding site [chemical binding]; other site 1074252006459 dimer interface [polypeptide binding]; other site 1074252006460 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1074252006461 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1074252006462 beta-galactosidase; Region: BGL; TIGR03356 1074252006463 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1074252006464 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1074252006465 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1074252006466 active site 1074252006467 P-loop; other site 1074252006468 phosphorylation site [posttranslational modification] 1074252006469 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1074252006470 methionine cluster; other site 1074252006471 active site 1074252006472 phosphorylation site [posttranslational modification] 1074252006473 metal binding site [ion binding]; metal-binding site 1074252006474 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1074252006475 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1074252006476 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1074252006477 putative substrate binding site [chemical binding]; other site 1074252006478 putative ATP binding site [chemical binding]; other site 1074252006479 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1074252006480 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1074252006481 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1074252006482 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1074252006483 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1074252006484 NAD-dependent deacetylase; Provisional; Region: PRK00481 1074252006485 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1074252006486 NAD+ binding site [chemical binding]; other site 1074252006487 substrate binding site [chemical binding]; other site 1074252006488 putative Zn binding site [ion binding]; other site 1074252006489 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1074252006490 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1074252006491 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1074252006492 active site 1074252006493 catalytic tetrad [active] 1074252006494 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1074252006495 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1074252006496 DNA binding residues [nucleotide binding] 1074252006497 putative dimer interface [polypeptide binding]; other site 1074252006498 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1074252006499 substrate binding site [chemical binding]; other site 1074252006500 catalytic residues [active] 1074252006501 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1074252006502 Peptidase family M23; Region: Peptidase_M23; pfam01551 1074252006503 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1074252006504 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1074252006505 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1074252006506 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1074252006507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1074252006508 active site 1074252006509 motif I; other site 1074252006510 motif II; other site 1074252006511 MAP domain; Region: MAP; pfam03642 1074252006512 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1074252006513 acetolactate synthase; Reviewed; Region: PRK08617 1074252006514 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1074252006515 PYR/PP interface [polypeptide binding]; other site 1074252006516 dimer interface [polypeptide binding]; other site 1074252006517 TPP binding site [chemical binding]; other site 1074252006518 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1074252006519 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1074252006520 TPP-binding site [chemical binding]; other site 1074252006521 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1074252006522 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1074252006523 23S rRNA interface [nucleotide binding]; other site 1074252006524 L3 interface [polypeptide binding]; other site 1074252006525 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1074252006526 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1074252006527 dimerization interface 3.5A [polypeptide binding]; other site 1074252006528 active site 1074252006529 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1074252006530 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1074252006531 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1074252006532 Walker A/P-loop; other site 1074252006533 ATP binding site [chemical binding]; other site 1074252006534 Q-loop/lid; other site 1074252006535 ABC transporter signature motif; other site 1074252006536 Walker B; other site 1074252006537 D-loop; other site 1074252006538 H-loop/switch region; other site 1074252006539 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1074252006540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1074252006541 Walker A/P-loop; other site 1074252006542 ATP binding site [chemical binding]; other site 1074252006543 Q-loop/lid; other site 1074252006544 ABC transporter signature motif; other site 1074252006545 Walker B; other site 1074252006546 D-loop; other site 1074252006547 H-loop/switch region; other site 1074252006548 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1074252006549 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1074252006550 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1074252006551 alphaNTD homodimer interface [polypeptide binding]; other site 1074252006552 alphaNTD - beta interaction site [polypeptide binding]; other site 1074252006553 alphaNTD - beta' interaction site [polypeptide binding]; other site 1074252006554 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1074252006555 30S ribosomal protein S11; Validated; Region: PRK05309 1074252006556 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1074252006557 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1074252006558 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1074252006559 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1074252006560 rRNA binding site [nucleotide binding]; other site 1074252006561 predicted 30S ribosome binding site; other site 1074252006562 adenylate kinase; Reviewed; Region: adk; PRK00279 1074252006563 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1074252006564 AMP-binding site [chemical binding]; other site 1074252006565 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1074252006566 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1074252006567 SecY translocase; Region: SecY; pfam00344 1074252006568 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1074252006569 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1074252006570 23S rRNA binding site [nucleotide binding]; other site 1074252006571 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1074252006572 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1074252006573 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1074252006574 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1074252006575 5S rRNA interface [nucleotide binding]; other site 1074252006576 L27 interface [polypeptide binding]; other site 1074252006577 23S rRNA interface [nucleotide binding]; other site 1074252006578 L5 interface [polypeptide binding]; other site 1074252006579 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1074252006580 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1074252006581 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1074252006582 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1074252006583 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1074252006584 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1074252006585 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1074252006586 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1074252006587 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1074252006588 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1074252006589 RNA binding site [nucleotide binding]; other site 1074252006590 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1074252006591 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1074252006592 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1074252006593 23S rRNA interface [nucleotide binding]; other site 1074252006594 putative translocon interaction site; other site 1074252006595 signal recognition particle (SRP54) interaction site; other site 1074252006596 L23 interface [polypeptide binding]; other site 1074252006597 trigger factor interaction site; other site 1074252006598 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1074252006599 23S rRNA interface [nucleotide binding]; other site 1074252006600 5S rRNA interface [nucleotide binding]; other site 1074252006601 putative antibiotic binding site [chemical binding]; other site 1074252006602 L25 interface [polypeptide binding]; other site 1074252006603 L27 interface [polypeptide binding]; other site 1074252006604 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1074252006605 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1074252006606 G-X-X-G motif; other site 1074252006607 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1074252006608 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1074252006609 putative translocon binding site; other site 1074252006610 protein-rRNA interface [nucleotide binding]; other site 1074252006611 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1074252006612 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1074252006613 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1074252006614 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1074252006615 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1074252006616 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1074252006617 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1074252006618 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1074252006619 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1074252006620 DNA topoisomerase III; Provisional; Region: PRK07726 1074252006621 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1074252006622 active site 1074252006623 putative interdomain interaction site [polypeptide binding]; other site 1074252006624 putative metal-binding site [ion binding]; other site 1074252006625 putative nucleotide binding site [chemical binding]; other site 1074252006626 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1074252006627 domain I; other site 1074252006628 DNA binding groove [nucleotide binding] 1074252006629 phosphate binding site [ion binding]; other site 1074252006630 domain II; other site 1074252006631 domain III; other site 1074252006632 nucleotide binding site [chemical binding]; other site 1074252006633 catalytic site [active] 1074252006634 domain IV; other site 1074252006635 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1074252006636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252006637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1074252006638 Coenzyme A binding pocket [chemical binding]; other site 1074252006639 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1074252006640 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1074252006641 Predicted permeases [General function prediction only]; Region: COG0679 1074252006642 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1074252006643 Protein export membrane protein; Region: SecD_SecF; cl14618 1074252006644 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1074252006645 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1074252006646 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1074252006647 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1074252006648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252006649 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252006650 putative substrate translocation pore; other site 1074252006651 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252006652 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1074252006653 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1074252006654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1074252006655 FeS/SAM binding site; other site 1074252006656 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1074252006657 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1074252006658 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1074252006659 GTP binding site; other site 1074252006660 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1074252006661 MoaE interaction surface [polypeptide binding]; other site 1074252006662 MoeB interaction surface [polypeptide binding]; other site 1074252006663 thiocarboxylated glycine; other site 1074252006664 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1074252006665 MoaE homodimer interface [polypeptide binding]; other site 1074252006666 MoaD interaction [polypeptide binding]; other site 1074252006667 active site residues [active] 1074252006668 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 1074252006669 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1074252006670 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1074252006671 dimer interface [polypeptide binding]; other site 1074252006672 putative functional site; other site 1074252006673 putative MPT binding site; other site 1074252006674 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1074252006675 trimer interface [polypeptide binding]; other site 1074252006676 dimer interface [polypeptide binding]; other site 1074252006677 putative active site [active] 1074252006678 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1074252006679 MPT binding site; other site 1074252006680 trimer interface [polypeptide binding]; other site 1074252006681 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1074252006682 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1074252006683 ATP binding site [chemical binding]; other site 1074252006684 substrate interface [chemical binding]; other site 1074252006685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1074252006686 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1074252006687 Walker A/P-loop; other site 1074252006688 ATP binding site [chemical binding]; other site 1074252006689 Q-loop/lid; other site 1074252006690 ABC transporter signature motif; other site 1074252006691 Walker B; other site 1074252006692 D-loop; other site 1074252006693 H-loop/switch region; other site 1074252006694 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1074252006695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252006696 dimer interface [polypeptide binding]; other site 1074252006697 conserved gate region; other site 1074252006698 putative PBP binding loops; other site 1074252006699 ABC-ATPase subunit interface; other site 1074252006700 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1074252006701 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1074252006702 substrate binding pocket [chemical binding]; other site 1074252006703 membrane-bound complex binding site; other site 1074252006704 hinge residues; other site 1074252006705 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1074252006706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252006707 Coenzyme A binding pocket [chemical binding]; other site 1074252006708 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1074252006709 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1074252006710 active site 1074252006711 dimerization interface [polypeptide binding]; other site 1074252006712 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1074252006713 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1074252006714 intersubunit interface [polypeptide binding]; other site 1074252006715 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1074252006716 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1074252006717 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1074252006718 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 1074252006719 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1074252006720 alpha-gamma subunit interface [polypeptide binding]; other site 1074252006721 beta-gamma subunit interface [polypeptide binding]; other site 1074252006722 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1074252006723 gamma-beta subunit interface [polypeptide binding]; other site 1074252006724 alpha-beta subunit interface [polypeptide binding]; other site 1074252006725 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1074252006726 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1074252006727 subunit interactions [polypeptide binding]; other site 1074252006728 active site 1074252006729 flap region; other site 1074252006730 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1074252006731 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1074252006732 dimer interface [polypeptide binding]; other site 1074252006733 catalytic residues [active] 1074252006734 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1074252006735 UreF; Region: UreF; pfam01730 1074252006736 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1074252006737 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1074252006738 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252006739 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252006740 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252006741 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1074252006742 Helix-turn-helix domain; Region: HTH_18; pfam12833 1074252006743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1074252006744 Surface antigen [General function prediction only]; Region: COG3942 1074252006745 CHAP domain; Region: CHAP; pfam05257 1074252006746 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1074252006747 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1074252006748 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1074252006749 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1074252006750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1074252006751 Surface antigen [General function prediction only]; Region: COG3942 1074252006752 CHAP domain; Region: CHAP; pfam05257 1074252006753 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1074252006754 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1074252006755 putative ligand binding site [chemical binding]; other site 1074252006756 putative NAD binding site [chemical binding]; other site 1074252006757 catalytic site [active] 1074252006758 hypothetical protein; Provisional; Region: PRK06753 1074252006759 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1074252006760 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1074252006761 Lysozyme subfamily 2; Region: LYZ2; smart00047 1074252006762 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1074252006763 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1074252006764 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1074252006765 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1074252006766 4Fe-4S binding domain; Region: Fer4; pfam00037 1074252006767 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1074252006768 [4Fe-4S] binding site [ion binding]; other site 1074252006769 molybdopterin cofactor binding site; other site 1074252006770 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1074252006771 molybdopterin cofactor binding site; other site 1074252006772 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1074252006773 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1074252006774 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1074252006775 active site 1074252006776 Predicted transcriptional regulator [Transcription]; Region: COG2378 1074252006777 HTH domain; Region: HTH_11; pfam08279 1074252006778 CAAX protease self-immunity; Region: Abi; pfam02517 1074252006779 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1074252006780 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1074252006781 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1074252006782 putative active site [active] 1074252006783 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1074252006784 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1074252006785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252006786 active site 1074252006787 motif I; other site 1074252006788 motif II; other site 1074252006789 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1074252006790 Sodium Bile acid symporter family; Region: SBF; pfam01758 1074252006791 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1074252006792 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1074252006793 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1074252006794 active site turn [active] 1074252006795 phosphorylation site [posttranslational modification] 1074252006796 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1074252006797 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1074252006798 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1074252006799 putative active site [active] 1074252006800 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1074252006801 putative hydrophobic ligand binding site [chemical binding]; other site 1074252006802 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1074252006803 oxidoreductase; Provisional; Region: PRK07985 1074252006804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1074252006805 NAD(P) binding site [chemical binding]; other site 1074252006806 active site 1074252006807 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1074252006808 amidohydrolase; Region: amidohydrolases; TIGR01891 1074252006809 metal binding site [ion binding]; metal-binding site 1074252006810 dimer interface [polypeptide binding]; other site 1074252006811 imidazolonepropionase; Validated; Region: PRK09356 1074252006812 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1074252006813 active site 1074252006814 urocanate hydratase; Provisional; Region: PRK05414 1074252006815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1074252006816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1074252006817 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1074252006818 dimerization interface [polypeptide binding]; other site 1074252006819 formimidoylglutamase; Provisional; Region: PRK13775 1074252006820 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1074252006821 putative active site [active] 1074252006822 putative metal binding site [ion binding]; other site 1074252006823 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1074252006824 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1074252006825 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1074252006826 active site 1074252006827 dimer interface [polypeptide binding]; other site 1074252006828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1074252006829 MOSC domain; Region: MOSC; pfam03473 1074252006830 3-alpha domain; Region: 3-alpha; pfam03475 1074252006831 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1074252006832 active site 1074252006833 catalytic residues [active] 1074252006834 Uncharacterized conserved protein [Function unknown]; Region: COG1742 1074252006835 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1074252006836 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1074252006837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1074252006838 Walker A/P-loop; other site 1074252006839 ATP binding site [chemical binding]; other site 1074252006840 Q-loop/lid; other site 1074252006841 ABC transporter signature motif; other site 1074252006842 Walker B; other site 1074252006843 D-loop; other site 1074252006844 H-loop/switch region; other site 1074252006845 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1074252006846 Predicted membrane protein [Function unknown]; Region: COG3152 1074252006847 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1074252006848 active site 1074252006849 DNA binding site [nucleotide binding] 1074252006850 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1074252006851 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1074252006852 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1074252006853 homotetramer interface [polypeptide binding]; other site 1074252006854 FMN binding site [chemical binding]; other site 1074252006855 homodimer contacts [polypeptide binding]; other site 1074252006856 putative active site [active] 1074252006857 putative substrate binding site [chemical binding]; other site 1074252006858 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1074252006859 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1074252006860 oligomer interface [polypeptide binding]; other site 1074252006861 metal binding site [ion binding]; metal-binding site 1074252006862 metal binding site [ion binding]; metal-binding site 1074252006863 putative Cl binding site [ion binding]; other site 1074252006864 aspartate ring; other site 1074252006865 basic sphincter; other site 1074252006866 hydrophobic gate; other site 1074252006867 periplasmic entrance; other site 1074252006868 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1074252006869 active site 1074252006870 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1074252006871 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1074252006872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252006873 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1074252006874 putative substrate translocation pore; other site 1074252006875 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1074252006876 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1074252006877 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1074252006878 HlyD family secretion protein; Region: HlyD_3; pfam13437 1074252006879 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1074252006880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252006881 putative substrate translocation pore; other site 1074252006882 Predicted membrane protein [Function unknown]; Region: COG4640 1074252006883 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1074252006884 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1074252006885 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1074252006886 putative Zn2+ binding site [ion binding]; other site 1074252006887 putative DNA binding site [nucleotide binding]; other site 1074252006888 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1074252006889 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1074252006890 putative active site [active] 1074252006891 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1074252006892 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1074252006893 Walker A/P-loop; other site 1074252006894 ATP binding site [chemical binding]; other site 1074252006895 Q-loop/lid; other site 1074252006896 ABC transporter signature motif; other site 1074252006897 Walker B; other site 1074252006898 D-loop; other site 1074252006899 H-loop/switch region; other site 1074252006900 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1074252006901 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1074252006902 FtsX-like permease family; Region: FtsX; pfam02687 1074252006903 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1074252006904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252006905 active site 1074252006906 phosphorylation site [posttranslational modification] 1074252006907 intermolecular recognition site; other site 1074252006908 dimerization interface [polypeptide binding]; other site 1074252006909 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1074252006910 DNA binding site [nucleotide binding] 1074252006911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1074252006912 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1074252006913 dimerization interface [polypeptide binding]; other site 1074252006914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1074252006915 dimer interface [polypeptide binding]; other site 1074252006916 phosphorylation site [posttranslational modification] 1074252006917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252006918 ATP binding site [chemical binding]; other site 1074252006919 Mg2+ binding site [ion binding]; other site 1074252006920 G-X-G motif; other site 1074252006921 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1074252006922 LytTr DNA-binding domain; Region: LytTR; smart00850 1074252006923 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1074252006924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1074252006925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1074252006926 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1074252006927 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1074252006928 Walker A/P-loop; other site 1074252006929 ATP binding site [chemical binding]; other site 1074252006930 Q-loop/lid; other site 1074252006931 ABC transporter signature motif; other site 1074252006932 Walker B; other site 1074252006933 D-loop; other site 1074252006934 H-loop/switch region; other site 1074252006935 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1074252006936 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1074252006937 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 1074252006938 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1074252006939 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1074252006940 L-lactate permease; Region: Lactate_perm; cl00701 1074252006941 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1074252006942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252006943 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1074252006944 Coenzyme A binding pocket [chemical binding]; other site 1074252006945 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1074252006946 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1074252006947 NAD(P) binding site [chemical binding]; other site 1074252006948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252006949 Coenzyme A binding pocket [chemical binding]; other site 1074252006950 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1074252006951 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1074252006952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252006953 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1074252006954 Predicted membrane protein [Function unknown]; Region: COG1511 1074252006955 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1074252006956 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1074252006957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1074252006958 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1074252006959 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1074252006960 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1074252006961 Cl binding site [ion binding]; other site 1074252006962 oligomer interface [polypeptide binding]; other site 1074252006963 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1074252006964 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1074252006965 active site turn [active] 1074252006966 phosphorylation site [posttranslational modification] 1074252006967 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1074252006968 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1074252006969 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1074252006970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1074252006971 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1074252006972 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1074252006973 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1074252006974 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1074252006975 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1074252006976 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1074252006977 MarR family; Region: MarR_2; pfam12802 1074252006978 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1074252006979 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1074252006980 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1074252006981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252006982 putative substrate translocation pore; other site 1074252006983 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1074252006984 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1074252006985 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1074252006986 DNA binding residues [nucleotide binding] 1074252006987 dimer interface [polypeptide binding]; other site 1074252006988 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1074252006989 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1074252006990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252006991 active site 1074252006992 phosphorylation site [posttranslational modification] 1074252006993 intermolecular recognition site; other site 1074252006994 dimerization interface [polypeptide binding]; other site 1074252006995 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1074252006996 DNA binding residues [nucleotide binding] 1074252006997 dimerization interface [polypeptide binding]; other site 1074252006998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1074252006999 Histidine kinase; Region: HisKA_3; pfam07730 1074252007000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252007001 ATP binding site [chemical binding]; other site 1074252007002 Mg2+ binding site [ion binding]; other site 1074252007003 G-X-G motif; other site 1074252007004 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1074252007005 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1074252007006 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1074252007007 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1074252007008 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1074252007009 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1074252007010 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1074252007011 [4Fe-4S] binding site [ion binding]; other site 1074252007012 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1074252007013 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1074252007014 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1074252007015 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1074252007016 molybdopterin cofactor binding site; other site 1074252007017 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1074252007018 active site 1074252007019 SAM binding site [chemical binding]; other site 1074252007020 homodimer interface [polypeptide binding]; other site 1074252007021 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1074252007022 [2Fe-2S] cluster binding site [ion binding]; other site 1074252007023 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1074252007024 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1074252007025 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1074252007026 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1074252007027 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1074252007028 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1074252007029 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1074252007030 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1074252007031 putative active site [active] 1074252007032 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1074252007033 active site 1074252007034 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1074252007035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252007036 Coenzyme A binding pocket [chemical binding]; other site 1074252007037 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1074252007038 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1074252007039 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1074252007040 putative hydrophobic ligand binding site [chemical binding]; other site 1074252007041 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1074252007042 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1074252007043 intersubunit interface [polypeptide binding]; other site 1074252007044 YodA lipocalin-like domain; Region: YodA; pfam09223 1074252007045 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1074252007046 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1074252007047 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1074252007048 Thioredoxin; Region: Thioredoxin_4; cl17273 1074252007049 FemAB family; Region: FemAB; pfam02388 1074252007050 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1074252007051 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1074252007052 Walker A/P-loop; other site 1074252007053 ATP binding site [chemical binding]; other site 1074252007054 Q-loop/lid; other site 1074252007055 ABC transporter signature motif; other site 1074252007056 Walker B; other site 1074252007057 D-loop; other site 1074252007058 H-loop/switch region; other site 1074252007059 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1074252007060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252007061 dimer interface [polypeptide binding]; other site 1074252007062 conserved gate region; other site 1074252007063 putative PBP binding loops; other site 1074252007064 ABC-ATPase subunit interface; other site 1074252007065 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1074252007066 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1074252007067 substrate binding pocket [chemical binding]; other site 1074252007068 membrane-bound complex binding site; other site 1074252007069 hinge residues; other site 1074252007070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252007071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252007072 putative substrate translocation pore; other site 1074252007073 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1074252007074 catalytic core [active] 1074252007075 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1074252007076 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1074252007077 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1074252007078 B domain; Region: B; pfam02216 1074252007079 B domain; Region: B; pfam02216 1074252007080 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 1074252007081 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1074252007082 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1074252007083 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1074252007084 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1074252007085 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1074252007086 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1074252007087 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1074252007088 catalytic residue [active] 1074252007089 biotin synthase; Validated; Region: PRK06256 1074252007090 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1074252007091 FeS/SAM binding site; other site 1074252007092 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1074252007093 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1074252007094 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1074252007095 inhibitor-cofactor binding pocket; inhibition site 1074252007096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252007097 catalytic residue [active] 1074252007098 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1074252007099 AAA domain; Region: AAA_26; pfam13500 1074252007101 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1074252007102 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1074252007103 Walker A/P-loop; other site 1074252007104 ATP binding site [chemical binding]; other site 1074252007105 Q-loop/lid; other site 1074252007106 ABC transporter signature motif; other site 1074252007107 Walker B; other site 1074252007108 D-loop; other site 1074252007109 H-loop/switch region; other site 1074252007110 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1074252007111 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1074252007112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1074252007113 Walker A/P-loop; other site 1074252007114 ATP binding site [chemical binding]; other site 1074252007115 Q-loop/lid; other site 1074252007116 ABC transporter signature motif; other site 1074252007117 Walker B; other site 1074252007118 D-loop; other site 1074252007119 H-loop/switch region; other site 1074252007120 Predicted membrane protein [Function unknown]; Region: COG2246 1074252007121 GtrA-like protein; Region: GtrA; pfam04138 1074252007122 glycerate kinase; Region: TIGR00045 1074252007123 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1074252007124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252007125 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1074252007126 putative substrate translocation pore; other site 1074252007127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1074252007128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1074252007129 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1074252007130 putative phosphoesterase; Region: acc_ester; TIGR03729 1074252007131 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1074252007132 Spore germination protein; Region: Spore_permease; cl17796 1074252007133 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1074252007134 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1074252007135 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1074252007136 Beta-lactamase; Region: Beta-lactamase; pfam00144 1074252007137 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1074252007138 extended (e) SDRs; Region: SDR_e; cd08946 1074252007139 NAD(P) binding site [chemical binding]; other site 1074252007140 active site 1074252007141 substrate binding site [chemical binding]; other site 1074252007142 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1074252007143 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1074252007144 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1074252007145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252007146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252007147 putative substrate translocation pore; other site 1074252007148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252007149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252007150 dimer interface [polypeptide binding]; other site 1074252007151 conserved gate region; other site 1074252007152 ABC-ATPase subunit interface; other site 1074252007153 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1074252007154 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1074252007155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252007156 dimer interface [polypeptide binding]; other site 1074252007157 conserved gate region; other site 1074252007158 putative PBP binding loops; other site 1074252007159 ABC-ATPase subunit interface; other site 1074252007160 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1074252007161 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1074252007162 Walker A/P-loop; other site 1074252007163 ATP binding site [chemical binding]; other site 1074252007164 Q-loop/lid; other site 1074252007165 ABC transporter signature motif; other site 1074252007166 Walker B; other site 1074252007167 D-loop; other site 1074252007168 H-loop/switch region; other site 1074252007169 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1074252007170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1074252007171 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1074252007172 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1074252007173 amino acid transporter; Region: 2A0306; TIGR00909 1074252007174 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1074252007175 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1074252007176 substrate binding pocket [chemical binding]; other site 1074252007177 catalytic triad [active] 1074252007178 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1074252007179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252007180 putative substrate translocation pore; other site 1074252007181 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1074252007182 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1074252007183 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1074252007184 Walker A/P-loop; other site 1074252007185 ATP binding site [chemical binding]; other site 1074252007186 Q-loop/lid; other site 1074252007187 ABC transporter signature motif; other site 1074252007188 Walker B; other site 1074252007189 D-loop; other site 1074252007190 H-loop/switch region; other site 1074252007191 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1074252007192 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1074252007193 oligomer interface [polypeptide binding]; other site 1074252007194 active site 1074252007195 metal binding site [ion binding]; metal-binding site 1074252007196 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1074252007197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1074252007198 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1074252007199 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1074252007200 active site 1074252007201 FMN binding site [chemical binding]; other site 1074252007202 substrate binding site [chemical binding]; other site 1074252007203 3Fe-4S cluster binding site [ion binding]; other site 1074252007204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252007205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252007206 putative substrate translocation pore; other site 1074252007207 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1074252007208 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1074252007209 Walker A/P-loop; other site 1074252007210 ATP binding site [chemical binding]; other site 1074252007211 Q-loop/lid; other site 1074252007212 ABC transporter signature motif; other site 1074252007213 Walker B; other site 1074252007214 D-loop; other site 1074252007215 H-loop/switch region; other site 1074252007216 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1074252007217 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1074252007218 Walker A/P-loop; other site 1074252007219 ATP binding site [chemical binding]; other site 1074252007220 Q-loop/lid; other site 1074252007221 ABC transporter signature motif; other site 1074252007222 Walker B; other site 1074252007223 D-loop; other site 1074252007224 H-loop/switch region; other site 1074252007225 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1074252007226 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1074252007227 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1074252007228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252007229 dimer interface [polypeptide binding]; other site 1074252007230 conserved gate region; other site 1074252007231 putative PBP binding loops; other site 1074252007232 ABC-ATPase subunit interface; other site 1074252007233 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1074252007234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1074252007235 dimer interface [polypeptide binding]; other site 1074252007236 conserved gate region; other site 1074252007237 putative PBP binding loops; other site 1074252007238 ABC-ATPase subunit interface; other site 1074252007239 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1074252007240 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1074252007241 substrate binding site [chemical binding]; other site 1074252007242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1074252007243 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1074252007244 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1074252007245 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1074252007246 short chain dehydrogenase; Validated; Region: PRK08589 1074252007247 classical (c) SDRs; Region: SDR_c; cd05233 1074252007248 NAD(P) binding site [chemical binding]; other site 1074252007249 active site 1074252007250 AbgT putative transporter family; Region: ABG_transport; pfam03806 1074252007251 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1074252007252 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1074252007253 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1074252007254 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1074252007255 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1074252007256 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1074252007257 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1074252007258 classical (c) SDRs; Region: SDR_c; cd05233 1074252007259 NAD(P) binding site [chemical binding]; other site 1074252007260 active site 1074252007261 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1074252007262 transposase/IS protein; Provisional; Region: PRK09183 1074252007263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252007264 Walker A motif; other site 1074252007265 ATP binding site [chemical binding]; other site 1074252007266 Walker B motif; other site 1074252007267 arginine finger; other site 1074252007268 Winged helix-turn helix; Region: HTH_29; pfam13551 1074252007269 Integrase core domain; Region: rve; pfam00665 1074252007270 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252007271 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252007272 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252007273 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1074252007274 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1074252007275 PLD-like domain; Region: PLDc_2; pfam13091 1074252007276 putative homodimer interface [polypeptide binding]; other site 1074252007277 putative active site [active] 1074252007278 catalytic site [active] 1074252007279 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1074252007280 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1074252007281 ATP binding site [chemical binding]; other site 1074252007282 putative Mg++ binding site [ion binding]; other site 1074252007283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1074252007284 nucleotide binding region [chemical binding]; other site 1074252007285 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1074252007286 ATP-binding site [chemical binding]; other site 1074252007287 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1074252007288 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1074252007289 active site 1074252007290 8-oxo-dGMP binding site [chemical binding]; other site 1074252007291 nudix motif; other site 1074252007292 metal binding site [ion binding]; metal-binding site 1074252007293 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1074252007294 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1074252007295 active site 1074252007296 substrate binding site [chemical binding]; other site 1074252007297 metal binding site [ion binding]; metal-binding site 1074252007298 H+ Antiporter protein; Region: 2A0121; TIGR00900 1074252007300 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252007301 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1074252007302 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252007303 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1074252007304 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1074252007305 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1074252007306 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1074252007307 active site 1074252007308 tetramer interface; other site 1074252007309 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1074252007310 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1074252007311 Fibronectin binding repeat; Region: Fn_bind; pfam02986 1074252007312 GntP family permease; Region: GntP_permease; pfam02447 1074252007313 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1074252007314 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1074252007315 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1074252007316 N- and C-terminal domain interface [polypeptide binding]; other site 1074252007317 active site 1074252007318 catalytic site [active] 1074252007319 metal binding site [ion binding]; metal-binding site 1074252007320 carbohydrate binding site [chemical binding]; other site 1074252007321 ATP binding site [chemical binding]; other site 1074252007322 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1074252007323 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1074252007324 DNA-binding site [nucleotide binding]; DNA binding site 1074252007325 FCD domain; Region: FCD; pfam07729 1074252007326 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1074252007327 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1074252007328 DNA binding residues [nucleotide binding] 1074252007329 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1074252007330 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1074252007331 synthetase active site [active] 1074252007332 NTP binding site [chemical binding]; other site 1074252007333 metal binding site [ion binding]; metal-binding site 1074252007334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1074252007335 Predicted membrane protein [Function unknown]; Region: COG1289 1074252007336 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1074252007337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252007338 D-galactonate transporter; Region: 2A0114; TIGR00893 1074252007339 putative substrate translocation pore; other site 1074252007340 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1074252007341 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1074252007342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1074252007343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1074252007344 putative substrate translocation pore; other site 1074252007346 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1074252007347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1074252007348 Walker A/P-loop; other site 1074252007349 ATP binding site [chemical binding]; other site 1074252007350 Q-loop/lid; other site 1074252007351 ABC transporter signature motif; other site 1074252007352 Walker B; other site 1074252007353 D-loop; other site 1074252007354 H-loop/switch region; other site 1074252007355 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1074252007356 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1074252007357 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1074252007358 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1074252007359 Predicted esterase [General function prediction only]; Region: COG0400 1074252007360 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1074252007361 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1074252007362 Zn binding site [ion binding]; other site 1074252007363 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1074252007364 Zn binding site [ion binding]; other site 1074252007365 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1074252007366 MarR family; Region: MarR; pfam01047 1074252007367 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1074252007368 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1074252007369 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1074252007370 putative metal binding site [ion binding]; other site 1074252007371 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1074252007372 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1074252007373 dimer interface [polypeptide binding]; other site 1074252007374 FMN binding site [chemical binding]; other site 1074252007375 D-lactate dehydrogenase; Provisional; Region: PRK12480 1074252007376 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1074252007377 homodimer interface [polypeptide binding]; other site 1074252007378 ligand binding site [chemical binding]; other site 1074252007379 NAD binding site [chemical binding]; other site 1074252007380 catalytic site [active] 1074252007382 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1074252007383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1074252007384 active site 1074252007385 motif I; other site 1074252007386 motif II; other site 1074252007387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1074252007388 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1074252007389 Walker A/P-loop; other site 1074252007390 ATP binding site [chemical binding]; other site 1074252007391 Q-loop/lid; other site 1074252007392 ABC transporter signature motif; other site 1074252007393 Walker B; other site 1074252007394 D-loop; other site 1074252007395 H-loop/switch region; other site 1074252007396 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1074252007397 active site 1074252007398 catalytic site [active] 1074252007399 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1074252007400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252007401 Coenzyme A binding pocket [chemical binding]; other site 1074252007402 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1074252007403 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1074252007404 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1074252007405 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1074252007406 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1074252007407 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1074252007408 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1074252007409 EamA-like transporter family; Region: EamA; pfam00892 1074252007410 EamA-like transporter family; Region: EamA; pfam00892 1074252007411 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1074252007412 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1074252007413 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1074252007414 catalytic residues [active] 1074252007415 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1074252007416 active site 1074252007418 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1074252007419 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1074252007420 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1074252007421 active site turn [active] 1074252007422 phosphorylation site [posttranslational modification] 1074252007423 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1074252007424 HPr interaction site; other site 1074252007425 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1074252007426 active site 1074252007427 phosphorylation site [posttranslational modification] 1074252007428 pyruvate oxidase; Provisional; Region: PRK08611 1074252007429 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1074252007430 PYR/PP interface [polypeptide binding]; other site 1074252007431 tetramer interface [polypeptide binding]; other site 1074252007432 dimer interface [polypeptide binding]; other site 1074252007433 TPP binding site [chemical binding]; other site 1074252007434 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1074252007435 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1074252007436 TPP-binding site [chemical binding]; other site 1074252007437 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1074252007438 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1074252007439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1074252007440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1074252007441 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1074252007442 putative dimerization interface [polypeptide binding]; other site 1074252007443 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1074252007444 Surface antigen [General function prediction only]; Region: COG3942 1074252007445 CHAP domain; Region: CHAP; pfam05257 1074252007446 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1074252007447 homodimer interface [polypeptide binding]; other site 1074252007448 catalytic residues [active] 1074252007449 NAD binding site [chemical binding]; other site 1074252007450 substrate binding pocket [chemical binding]; other site 1074252007451 flexible flap; other site 1074252007452 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1074252007453 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1074252007454 dimer interface [polypeptide binding]; other site 1074252007455 active site 1074252007456 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1074252007457 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1074252007458 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1074252007459 DNA binding site [nucleotide binding] 1074252007460 active site 1074252007461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252007462 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1074252007463 Walker A motif; other site 1074252007464 ATP binding site [chemical binding]; other site 1074252007465 Walker B motif; other site 1074252007466 arginine finger; other site 1074252007467 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1074252007468 UvrB/uvrC motif; Region: UVR; pfam02151 1074252007469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1074252007470 Walker A motif; other site 1074252007471 ATP binding site [chemical binding]; other site 1074252007472 Walker B motif; other site 1074252007473 arginine finger; other site 1074252007474 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1074252007475 Virus attachment protein p12 family; Region: P12; pfam12669 1074252007476 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1074252007477 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1074252007478 G1 box; other site 1074252007479 GTP/Mg2+ binding site [chemical binding]; other site 1074252007480 Switch I region; other site 1074252007481 G2 box; other site 1074252007482 G3 box; other site 1074252007483 Switch II region; other site 1074252007484 G4 box; other site 1074252007485 G5 box; other site 1074252007486 Nucleoside recognition; Region: Gate; pfam07670 1074252007487 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1074252007488 Nucleoside recognition; Region: Gate; pfam07670 1074252007489 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1074252007490 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1074252007491 Protein export membrane protein; Region: SecD_SecF; cl14618 1074252007492 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 1074252007493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1074252007494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1074252007495 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1074252007496 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1074252007497 Glutamate binding site [chemical binding]; other site 1074252007498 homodimer interface [polypeptide binding]; other site 1074252007499 NAD binding site [chemical binding]; other site 1074252007500 catalytic residues [active] 1074252007501 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1074252007502 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1074252007503 active site 1074252007504 substrate binding site [chemical binding]; other site 1074252007505 trimer interface [polypeptide binding]; other site 1074252007506 CoA binding site [chemical binding]; other site 1074252007507 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1074252007508 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1074252007509 metal-binding site [ion binding] 1074252007510 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1074252007511 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1074252007512 metal-binding site [ion binding] 1074252007513 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1074252007514 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1074252007515 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1074252007516 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1074252007517 metal-binding site [ion binding] 1074252007518 D-lactate dehydrogenase; Validated; Region: PRK08605 1074252007519 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1074252007520 homodimer interface [polypeptide binding]; other site 1074252007521 ligand binding site [chemical binding]; other site 1074252007522 NAD binding site [chemical binding]; other site 1074252007523 catalytic site [active] 1074252007524 transaminase; Reviewed; Region: PRK08068 1074252007525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1074252007526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252007527 homodimer interface [polypeptide binding]; other site 1074252007528 catalytic residue [active] 1074252007529 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1074252007530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1074252007531 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1074252007532 active site lid residues [active] 1074252007533 substrate binding pocket [chemical binding]; other site 1074252007534 catalytic residues [active] 1074252007535 substrate-Mg2+ binding site; other site 1074252007536 aspartate-rich region 1; other site 1074252007537 aspartate-rich region 2; other site 1074252007538 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1074252007539 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1074252007540 active site 1074252007541 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1074252007542 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1074252007543 Surface antigen [General function prediction only]; Region: COG3942 1074252007544 CHAP domain; Region: CHAP; pfam05257 1074252007545 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1074252007546 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1074252007547 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1074252007548 catalytic triad [active] 1074252007549 catalytic triad [active] 1074252007550 oxyanion hole [active] 1074252007551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252007552 Coenzyme A binding pocket [chemical binding]; other site 1074252007553 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1074252007554 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1074252007555 catalytic residue [active] 1074252007556 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1074252007557 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1074252007558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1074252007559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1074252007560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1074252007561 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1074252007562 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1074252007563 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1074252007564 NmrA-like family; Region: NmrA; pfam05368 1074252007565 NADP binding site [chemical binding]; other site 1074252007566 active site 1074252007567 regulatory binding site [polypeptide binding]; other site 1074252007568 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 1074252007569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1074252007570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1074252007571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1074252007572 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1074252007573 NAD(P) binding site [chemical binding]; other site 1074252007574 active site 1074252007575 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1074252007576 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1074252007577 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1074252007578 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1074252007579 putative NAD(P) binding site [chemical binding]; other site 1074252007580 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1074252007581 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1074252007582 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1074252007583 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1074252007584 Nucleoside recognition; Region: Gate; pfam07670 1074252007585 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1074252007586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1074252007587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 1074252007588 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1074252007589 Phosphotransferase enzyme family; Region: APH; pfam01636 1074252007590 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1074252007591 active site 1074252007592 ATP binding site [chemical binding]; other site 1074252007593 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1074252007594 active site 1074252007595 ATP binding site [chemical binding]; other site 1074252007596 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1074252007597 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1074252007598 quinone interaction residues [chemical binding]; other site 1074252007599 active site 1074252007600 catalytic residues [active] 1074252007601 FMN binding site [chemical binding]; other site 1074252007602 substrate binding site [chemical binding]; other site 1074252007603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1074252007604 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1074252007605 dimer interface [polypeptide binding]; other site 1074252007606 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1074252007607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1074252007608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1074252007609 Predicted acyl esterases [General function prediction only]; Region: COG2936 1074252007610 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1074252007611 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1074252007612 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1074252007613 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1074252007614 tetramerization interface [polypeptide binding]; other site 1074252007615 active site 1074252007616 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1074252007617 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1074252007618 active site 1074252007619 ATP-binding site [chemical binding]; other site 1074252007620 pantoate-binding site; other site 1074252007621 HXXH motif; other site 1074252007622 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1074252007623 oligomerization interface [polypeptide binding]; other site 1074252007624 active site 1074252007625 metal binding site [ion binding]; metal-binding site 1074252007626 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1074252007627 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1074252007628 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1074252007629 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1074252007630 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1074252007631 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1074252007632 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1074252007633 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1074252007634 NAD binding site [chemical binding]; other site 1074252007635 dimer interface [polypeptide binding]; other site 1074252007636 substrate binding site [chemical binding]; other site 1074252007637 amino acid transporter; Region: 2A0306; TIGR00909 1074252007638 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1074252007639 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1074252007640 inhibitor-cofactor binding pocket; inhibition site 1074252007641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252007642 catalytic residue [active] 1074252007643 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1074252007644 catalytic residue [active] 1074252007645 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1074252007646 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1074252007647 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1074252007648 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1074252007649 acyl-activating enzyme (AAE) consensus motif; other site 1074252007650 AMP binding site [chemical binding]; other site 1074252007651 active site 1074252007652 CoA binding site [chemical binding]; other site 1074252007653 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1074252007654 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1074252007655 choline dehydrogenase; Validated; Region: PRK02106 1074252007656 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1074252007657 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1074252007658 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1074252007659 tetramerization interface [polypeptide binding]; other site 1074252007660 NAD(P) binding site [chemical binding]; other site 1074252007661 catalytic residues [active] 1074252007662 Predicted transcriptional regulators [Transcription]; Region: COG1510 1074252007663 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1074252007664 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1074252007665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1074252007666 FeS/SAM binding site; other site 1074252007667 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1074252007668 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1074252007669 effector binding site; other site 1074252007670 active site 1074252007671 Zn binding site [ion binding]; other site 1074252007672 glycine loop; other site 1074252007673 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1074252007674 Citrate transporter; Region: CitMHS; pfam03600 1074252007675 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1074252007676 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1074252007677 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1074252007678 Flavodoxin; Region: Flavodoxin_1; pfam00258 1074252007679 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1074252007680 FAD binding pocket [chemical binding]; other site 1074252007681 FAD binding motif [chemical binding]; other site 1074252007682 catalytic residues [active] 1074252007683 NAD binding pocket [chemical binding]; other site 1074252007684 phosphate binding motif [ion binding]; other site 1074252007685 beta-alpha-beta structure motif; other site 1074252007686 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1074252007687 catalytic residues [active] 1074252007688 dimer interface [polypeptide binding]; other site 1074252007689 FtsX-like permease family; Region: FtsX; pfam02687 1074252007690 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1074252007691 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1074252007692 Walker A/P-loop; other site 1074252007693 ATP binding site [chemical binding]; other site 1074252007694 Q-loop/lid; other site 1074252007695 ABC transporter signature motif; other site 1074252007696 Walker B; other site 1074252007697 D-loop; other site 1074252007698 H-loop/switch region; other site 1074252007699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1074252007700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1074252007701 ATP binding site [chemical binding]; other site 1074252007702 Mg2+ binding site [ion binding]; other site 1074252007703 G-X-G motif; other site 1074252007704 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1074252007705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1074252007706 active site 1074252007707 phosphorylation site [posttranslational modification] 1074252007708 intermolecular recognition site; other site 1074252007709 dimerization interface [polypeptide binding]; other site 1074252007710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1074252007711 DNA binding site [nucleotide binding] 1074252007712 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1074252007713 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1074252007714 dimer interface [polypeptide binding]; other site 1074252007715 active site 1074252007716 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1074252007717 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 1074252007718 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1074252007719 MarR family; Region: MarR_2; pfam12802 1074252007720 Predicted esterase [General function prediction only]; Region: COG0627 1074252007721 S-formylglutathione hydrolase; Region: PLN02442 1074252007722 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1074252007723 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1074252007724 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1074252007725 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1074252007726 ligand binding site [chemical binding]; other site 1074252007727 flexible hinge region; other site 1074252007728 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1074252007729 carbamate kinase; Reviewed; Region: PRK12686 1074252007730 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1074252007731 putative substrate binding site [chemical binding]; other site 1074252007732 nucleotide binding site [chemical binding]; other site 1074252007733 nucleotide binding site [chemical binding]; other site 1074252007734 homodimer interface [polypeptide binding]; other site 1074252007735 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1074252007736 ornithine carbamoyltransferase; Validated; Region: PRK02102 1074252007737 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1074252007738 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1074252007739 arginine deiminase; Provisional; Region: PRK01388 1074252007740 Arginine repressor [Transcription]; Region: ArgR; COG1438 1074252007741 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1074252007742 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1074252007743 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1074252007744 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1074252007745 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1074252007746 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1074252007747 active site 1074252007748 Zn binding site [ion binding]; other site 1074252007750 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1074252007751 HTH domain; Region: HTH_11; pfam08279 1074252007752 PRD domain; Region: PRD; pfam00874 1074252007753 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1074252007754 active site 1074252007755 P-loop; other site 1074252007756 phosphorylation site [posttranslational modification] 1074252007757 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1074252007758 active site 1074252007759 phosphorylation site [posttranslational modification] 1074252007760 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1074252007761 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1074252007762 active site 1074252007763 P-loop; other site 1074252007764 phosphorylation site [posttranslational modification] 1074252007765 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1074252007766 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1074252007767 active site 1074252007768 phosphorylation site [posttranslational modification] 1074252007769 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1074252007770 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1074252007771 Predicted membrane protein [Function unknown]; Region: COG1511 1074252007772 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1074252007773 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1074252007774 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1074252007775 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1074252007776 CHAP domain; Region: CHAP; pfam05257 1074252007777 Isochorismatase family; Region: Isochorismatase; pfam00857 1074252007778 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1074252007779 catalytic triad [active] 1074252007780 conserved cis-peptide bond; other site 1074252007781 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1074252007782 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1074252007783 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1074252007784 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1074252007785 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1074252007786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1074252007787 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1074252007788 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1074252007789 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1074252007790 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1074252007791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1074252007792 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1074252007793 SecY translocase; Region: SecY; pfam00344 1074252007795 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1074252007798 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1074252007799 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1074252007800 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1074252007801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1074252007802 Coenzyme A binding pocket [chemical binding]; other site 1074252007803 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1074252007804 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1074252007805 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1074252007806 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1074252007807 Chain length determinant protein; Region: Wzz; cl15801 1074252007808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1074252007809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1074252007810 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1074252007811 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1074252007812 DXD motif; other site 1074252007813 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 1074252007814 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 1074252007815 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1074252007816 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1074252007817 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1074252007818 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1074252007819 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1074252007820 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1074252007821 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1074252007822 metal binding site [ion binding]; metal-binding site 1074252007823 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1074252007824 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1074252007825 substrate binding site [chemical binding]; other site 1074252007826 glutamase interaction surface [polypeptide binding]; other site 1074252007827 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1074252007828 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1074252007829 catalytic residues [active] 1074252007830 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 1074252007831 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1074252007832 putative active site [active] 1074252007833 oxyanion strand; other site 1074252007834 catalytic triad [active] 1074252007835 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1074252007836 putative active site pocket [active] 1074252007837 4-fold oligomerization interface [polypeptide binding]; other site 1074252007838 metal binding residues [ion binding]; metal-binding site 1074252007839 3-fold/trimer interface [polypeptide binding]; other site 1074252007840 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1074252007841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1074252007842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1074252007843 homodimer interface [polypeptide binding]; other site 1074252007844 catalytic residue [active] 1074252007845 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1074252007846 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1074252007847 NAD binding site [chemical binding]; other site 1074252007848 dimerization interface [polypeptide binding]; other site 1074252007849 product binding site; other site 1074252007850 substrate binding site [chemical binding]; other site 1074252007851 zinc binding site [ion binding]; other site 1074252007852 catalytic residues [active] 1074252007853 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 1074252007854 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1074252007855 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 1074252007856 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1074252007857 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1074252007858 putative active site [active] 1074252007859 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1074252007860 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1074252007861 Strictosidine synthase; Region: Str_synth; pfam03088 1074252007862 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1074252007863 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1074252007864 active site residue [active] 1074252007865 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1074252007866 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1074252007867 putative substrate binding pocket [chemical binding]; other site 1074252007868 AC domain interface; other site 1074252007869 catalytic triad [active] 1074252007870 AB domain interface; other site 1074252007871 interchain disulfide; other site 1074252007872 DinB superfamily; Region: DinB_2; pfam12867 1074252007873 Collagen binding domain; Region: Collagen_bind; pfam05737 1074252007874 Cna protein B-type domain; Region: Cna_B; pfam05738 1074252007875 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1074252007876 domain interaction interfaces [polypeptide binding]; other site 1074252007877 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1074252007878 domain interaction interfaces [polypeptide binding]; other site 1074252007879 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1074252007880 domain interaction interfaces [polypeptide binding]; other site 1074252007881 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1074252007882 domain interaction interfaces [polypeptide binding]; other site 1074252007883 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1074252007884 domain interaction interfaces [polypeptide binding]; other site 1074252007885 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1074252007886 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1074252007887 transmembrane helices; other site 1074252007888 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1074252007889 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1074252007890 hypothetical protein; Provisional; Region: PRK07758 1074252007891 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1074252007892 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1074252007893 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1074252007894 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1074252007895 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1074252007896 Walker A/P-loop; other site 1074252007897 ATP binding site [chemical binding]; other site 1074252007898 Q-loop/lid; other site 1074252007899 ABC transporter signature motif; other site 1074252007900 Walker B; other site 1074252007901 D-loop; other site 1074252007902 H-loop/switch region; other site 1074252007903 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1074252007904 FtsX-like permease family; Region: FtsX; pfam02687 1074252007905 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1074252007906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1074252007907 non-specific DNA binding site [nucleotide binding]; other site 1074252007908 salt bridge; other site 1074252007909 sequence-specific DNA binding site [nucleotide binding]; other site 1074252007910 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1074252007911 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1074252007912 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1074252007913 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1074252007914 ParB-like nuclease domain; Region: ParBc; pfam02195 1074252007915 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1074252007916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1074252007917 S-adenosylmethionine binding site [chemical binding]; other site 1074252007918 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1074252007919 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1074252007920 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1074252007921 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1074252007922 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1074252007923 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1074252007924 G1 box; other site 1074252007925 GTP/Mg2+ binding site [chemical binding]; other site 1074252007926 Switch I region; other site 1074252007927 G2 box; other site 1074252007928 Switch II region; other site 1074252007929 G3 box; other site 1074252007930 G4 box; other site 1074252007931 G5 box; other site 1074252007932 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1074252007933 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1074252007934 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399