-- dump date 20140620_073852 -- class Genbank::misc_feature -- table misc_feature_note -- id note 359786000001 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 359786000002 active site 359786000003 dimer interface [polypeptide binding]; other site 359786000004 magnesium binding site [ion binding]; other site 359786000005 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 359786000006 tetramer interface [polypeptide binding]; other site 359786000007 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 359786000008 active site 359786000009 Predicted transcriptional regulators [Transcription]; Region: COG1733 359786000010 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 359786000011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 359786000012 Integrase core domain; Region: rve; pfam00665 359786000013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 359786000014 Integrase core domain; Region: rve; pfam00665 359786000015 Predicted membrane protein [Function unknown]; Region: COG4640 359786000016 YolD-like protein; Region: YolD; pfam08863 359786000017 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 359786000018 Helix-turn-helix domain; Region: HTH_28; pfam13518 359786000019 Winged helix-turn helix; Region: HTH_29; pfam13551 359786000020 Homeodomain-like domain; Region: HTH_32; pfam13565 359786000021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 359786000022 Integrase core domain; Region: rve; pfam00665 359786000023 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 359786000024 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 359786000025 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 359786000026 catalytic residues [active] 359786000027 catalytic nucleophile [active] 359786000028 Presynaptic Site I dimer interface [polypeptide binding]; other site 359786000029 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 359786000030 Synaptic Flat tetramer interface [polypeptide binding]; other site 359786000031 Synaptic Site I dimer interface [polypeptide binding]; other site 359786000032 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 359786000033 DNA-binding interface [nucleotide binding]; DNA binding site 359786000034 Predicted transcriptional regulator [Transcription]; Region: COG3682 359786000035 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 359786000036 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 359786000037 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 359786000038 beta-lactamase TEM; Provisional; Region: PRK15442 359786000039 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 359786000040 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 359786000041 MarR family; Region: MarR_2; pfam12802 359786000042 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 359786000043 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 359786000044 NADP binding site [chemical binding]; other site 359786000045 dimer interface [polypeptide binding]; other site 359786000046 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 359786000047 putative DNA binding site [nucleotide binding]; other site 359786000048 putative Zn2+ binding site [ion binding]; other site 359786000049 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 359786000050 Cadmium resistance transporter; Region: Cad; pfam03596 359786000051 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 359786000052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 359786000053 Integrase core domain; Region: rve; pfam00665 359786000054 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 359786000055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786000056 Coenzyme A binding pocket [chemical binding]; other site 359786000057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 359786000058 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 359786000059 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 359786000060 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 359786000061 Phosphotransferase enzyme family; Region: APH; pfam01636 359786000062 active site 359786000063 ATP binding site [chemical binding]; other site 359786000064 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 359786000065 substrate binding site [chemical binding]; other site 359786000066 Transposase, Mutator family; Region: Transposase_mut; pfam00872 359786000067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 359786000068 Integrase core domain; Region: rve; pfam00665 359786000069 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 359786000070 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 359786000071 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 359786000072 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 359786000073 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 359786000074 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 359786000075 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 359786000076 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 359786000077 active site 359786000078 dimer interface [polypeptide binding]; other site 359786000079 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 359786000080 dimer interface [polypeptide binding]; other site 359786000081 active site 359786000082 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 359786000083 DnaA N-terminal domain; Region: DnaA_N; pfam11638 359786000084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786000085 Walker A motif; other site 359786000086 ATP binding site [chemical binding]; other site 359786000087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 359786000088 Walker B motif; other site 359786000089 arginine finger; other site 359786000090 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 359786000091 DnaA box-binding interface [nucleotide binding]; other site 359786000092 DNA polymerase III subunit beta; Validated; Region: PRK05643 359786000093 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 359786000094 putative DNA binding surface [nucleotide binding]; other site 359786000095 dimer interface [polypeptide binding]; other site 359786000096 beta-clamp/clamp loader binding surface; other site 359786000097 beta-clamp/translesion DNA polymerase binding surface; other site 359786000098 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 359786000099 recF protein; Region: recf; TIGR00611 359786000100 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 359786000101 Walker A/P-loop; other site 359786000102 ATP binding site [chemical binding]; other site 359786000103 Q-loop/lid; other site 359786000104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786000105 ABC transporter signature motif; other site 359786000106 Walker B; other site 359786000107 D-loop; other site 359786000108 H-loop/switch region; other site 359786000109 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 359786000110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786000111 Mg2+ binding site [ion binding]; other site 359786000112 G-X-G motif; other site 359786000113 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 359786000114 anchoring element; other site 359786000115 dimer interface [polypeptide binding]; other site 359786000116 ATP binding site [chemical binding]; other site 359786000117 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 359786000118 active site 359786000119 putative metal-binding site [ion binding]; other site 359786000120 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 359786000121 DNA gyrase subunit A; Validated; Region: PRK05560 359786000122 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 359786000123 CAP-like domain; other site 359786000124 active site 359786000125 primary dimer interface [polypeptide binding]; other site 359786000126 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 359786000127 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 359786000128 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 359786000129 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 359786000130 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 359786000131 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 359786000132 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 359786000133 putative substrate binding site [chemical binding]; other site 359786000134 putative ATP binding site [chemical binding]; other site 359786000135 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 359786000136 active sites [active] 359786000137 tetramer interface [polypeptide binding]; other site 359786000138 seryl-tRNA synthetase; Provisional; Region: PRK05431 359786000139 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 359786000140 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 359786000141 dimer interface [polypeptide binding]; other site 359786000142 active site 359786000143 motif 1; other site 359786000144 motif 2; other site 359786000145 motif 3; other site 359786000146 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 359786000147 Predicted membrane protein [Function unknown]; Region: COG4392 359786000148 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 359786000149 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 359786000150 Predicted membrane protein [Function unknown]; Region: COG4241 359786000151 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 359786000152 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 359786000153 DHH family; Region: DHH; pfam01368 359786000154 DHHA1 domain; Region: DHHA1; pfam02272 359786000155 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 359786000156 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 359786000157 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 359786000158 replicative DNA helicase; Region: DnaB; TIGR00665 359786000159 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 359786000160 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 359786000161 Walker A motif; other site 359786000162 ATP binding site [chemical binding]; other site 359786000163 Walker B motif; other site 359786000164 DNA binding loops [nucleotide binding] 359786000165 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 359786000166 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 359786000167 GDP-binding site [chemical binding]; other site 359786000168 ACT binding site; other site 359786000169 IMP binding site; other site 359786000170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 359786000171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786000172 active site 359786000173 phosphorylation site [posttranslational modification] 359786000174 intermolecular recognition site; other site 359786000175 dimerization interface [polypeptide binding]; other site 359786000176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 359786000177 DNA binding site [nucleotide binding] 359786000178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 359786000179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 359786000180 dimerization interface [polypeptide binding]; other site 359786000181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 359786000182 putative active site [active] 359786000183 heme pocket [chemical binding]; other site 359786000184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 359786000185 dimer interface [polypeptide binding]; other site 359786000186 phosphorylation site [posttranslational modification] 359786000187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786000188 ATP binding site [chemical binding]; other site 359786000189 Mg2+ binding site [ion binding]; other site 359786000190 G-X-G motif; other site 359786000191 YycH protein; Region: YycH; pfam07435 359786000192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 359786000193 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 359786000194 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 359786000195 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 359786000196 putative active site [active] 359786000197 putative metal binding site [ion binding]; other site 359786000198 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 359786000199 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 359786000200 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 359786000201 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 359786000202 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 359786000203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 359786000204 Integrase core domain; Region: rve; pfam00665 359786000205 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 359786000206 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 359786000207 putative active site [active] 359786000208 catalytic site [active] 359786000209 putative metal binding site [ion binding]; other site 359786000210 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 359786000211 putative active site [active] 359786000212 putative catalytic site [active] 359786000213 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 359786000214 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 359786000215 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 359786000216 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 359786000217 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 359786000218 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 359786000219 Predicted transcriptional regulator [Transcription]; Region: COG3682 359786000220 MarR family; Region: MarR_2; pfam12802 359786000221 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 359786000222 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 359786000223 nucleotide binding site [chemical binding]; other site 359786000224 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 359786000225 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 359786000226 active site residue [active] 359786000227 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 359786000228 CPxP motif; other site 359786000229 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 359786000230 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 359786000231 putative homodimer interface [polypeptide binding]; other site 359786000232 putative homotetramer interface [polypeptide binding]; other site 359786000233 putative metal binding site [ion binding]; other site 359786000234 putative homodimer-homodimer interface [polypeptide binding]; other site 359786000235 putative allosteric switch controlling residues; other site 359786000236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786000237 S-adenosylmethionine binding site [chemical binding]; other site 359786000238 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 359786000239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786000240 S-adenosylmethionine binding site [chemical binding]; other site 359786000241 aminoglycoside resistance protein; Provisional; Region: PRK13746 359786000242 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 359786000243 active site 359786000244 NTP binding site [chemical binding]; other site 359786000245 metal binding triad [ion binding]; metal-binding site 359786000246 antibiotic binding site [chemical binding]; other site 359786000247 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 359786000248 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 359786000249 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 359786000250 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 359786000251 Int/Topo IB signature motif; other site 359786000252 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 359786000253 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 359786000254 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 359786000255 Int/Topo IB signature motif; other site 359786000256 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 359786000257 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 359786000258 MPN+ (JAMM) motif; other site 359786000259 Zinc-binding site [ion binding]; other site 359786000260 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 359786000261 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 359786000262 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 359786000263 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 359786000264 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 359786000265 catalytic residues [active] 359786000266 catalytic nucleophile [active] 359786000267 Presynaptic Site I dimer interface [polypeptide binding]; other site 359786000268 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 359786000269 Synaptic Flat tetramer interface [polypeptide binding]; other site 359786000270 Synaptic Site I dimer interface [polypeptide binding]; other site 359786000271 DNA binding site [nucleotide binding] 359786000272 Recombinase; Region: Recombinase; pfam07508 359786000273 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 359786000274 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 359786000275 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 359786000276 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 359786000277 catalytic residues [active] 359786000278 catalytic nucleophile [active] 359786000279 Recombinase; Region: Recombinase; pfam07508 359786000280 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 359786000281 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 359786000282 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 359786000283 Integrase core domain; Region: rve; pfam00665 359786000284 Integrase core domain; Region: rve_3; cl15866 359786000285 HTH-like domain; Region: HTH_21; pfam13276 359786000286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 359786000287 Homeodomain-like domain; Region: HTH_23; cl17451 359786000288 Predicted membrane protein [Function unknown]; Region: COG1288 359786000289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 359786000290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786000291 active site 359786000292 phosphorylation site [posttranslational modification] 359786000293 intermolecular recognition site; other site 359786000294 dimerization interface [polypeptide binding]; other site 359786000295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 359786000296 DNA binding site [nucleotide binding] 359786000297 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 359786000298 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 359786000299 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 359786000300 Ligand Binding Site [chemical binding]; other site 359786000301 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 359786000302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 359786000303 dimer interface [polypeptide binding]; other site 359786000304 phosphorylation site [posttranslational modification] 359786000305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786000306 ATP binding site [chemical binding]; other site 359786000307 Mg2+ binding site [ion binding]; other site 359786000308 G-X-G motif; other site 359786000309 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 359786000310 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 359786000311 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 359786000312 Soluble P-type ATPase [General function prediction only]; Region: COG4087 359786000313 potassium-transporting ATPase subunit C; Provisional; Region: PRK14000 359786000314 Protein kinase domain; Region: Pkinase; pfam00069 359786000315 Catalytic domain of Protein Kinases; Region: PKc; cd00180 359786000316 active site 359786000317 ATP binding site [chemical binding]; other site 359786000318 substrate binding site [chemical binding]; other site 359786000319 activation loop (A-loop); other site 359786000320 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 359786000321 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 359786000322 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 359786000323 putative homodimer interface [polypeptide binding]; other site 359786000324 putative homotetramer interface [polypeptide binding]; other site 359786000325 putative metal binding site [ion binding]; other site 359786000326 putative homodimer-homodimer interface [polypeptide binding]; other site 359786000327 putative allosteric switch controlling residues; other site 359786000328 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 359786000329 active site residue [active] 359786000330 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 359786000331 CPxP motif; other site 359786000332 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 359786000333 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 359786000334 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 359786000335 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 359786000336 active site residue [active] 359786000337 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 359786000338 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 359786000339 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 359786000340 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 359786000341 FMN binding site [chemical binding]; other site 359786000342 active site 359786000343 catalytic residues [active] 359786000344 substrate binding site [chemical binding]; other site 359786000345 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 359786000346 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 359786000347 active site 359786000348 catalytic site [active] 359786000349 putative metal binding site [ion binding]; other site 359786000350 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786000351 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786000352 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786000353 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786000354 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786000355 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 359786000356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 359786000357 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 359786000358 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 359786000359 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 359786000360 metal binding site [ion binding]; metal-binding site 359786000361 dimer interface [polypeptide binding]; other site 359786000362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786000363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 359786000364 putative substrate translocation pore; other site 359786000365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786000366 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 359786000367 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 359786000368 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 359786000369 PhoU domain; Region: PhoU; pfam01895 359786000370 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 359786000371 EamA-like transporter family; Region: EamA; pfam00892 359786000372 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 359786000373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 359786000374 DNA-binding site [nucleotide binding]; DNA binding site 359786000375 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 359786000376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786000377 homodimer interface [polypeptide binding]; other site 359786000378 catalytic residue [active] 359786000379 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 359786000380 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 359786000381 L-lactate permease; Region: Lactate_perm; cl00701 359786000382 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786000383 B domain; Region: B; pfam02216 359786000384 B domain; Region: B; pfam02216 359786000385 B domain; Region: B; pfam02216 359786000386 B domain; Region: B; pfam02216 359786000387 B domain; Region: B; pfam02216 359786000388 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 359786000389 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786000390 Transcriptional regulators [Transcription]; Region: MarR; COG1846 359786000391 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786000392 Transcriptional regulators [Transcription]; Region: MarR; COG1846 359786000393 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 359786000394 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786000395 ABC-ATPase subunit interface; other site 359786000396 dimer interface [polypeptide binding]; other site 359786000397 putative PBP binding regions; other site 359786000398 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 359786000399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786000400 ABC-ATPase subunit interface; other site 359786000401 dimer interface [polypeptide binding]; other site 359786000402 putative PBP binding regions; other site 359786000403 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 359786000404 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 359786000405 siderophore binding site; other site 359786000406 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 359786000407 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 359786000408 dimer interface [polypeptide binding]; other site 359786000409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786000410 catalytic residue [active] 359786000411 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 359786000412 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 359786000413 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 359786000414 IucA / IucC family; Region: IucA_IucC; pfam04183 359786000415 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 359786000416 drug efflux system protein MdtG; Provisional; Region: PRK09874 359786000417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786000418 putative substrate translocation pore; other site 359786000419 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 359786000420 IucA / IucC family; Region: IucA_IucC; pfam04183 359786000421 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 359786000422 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 359786000423 IucA / IucC family; Region: IucA_IucC; pfam04183 359786000424 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 359786000425 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 359786000426 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 359786000427 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 359786000428 dimer interface [polypeptide binding]; other site 359786000429 active site 359786000430 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 359786000431 catalytic residues [active] 359786000432 substrate binding site [chemical binding]; other site 359786000433 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 359786000434 ParB-like nuclease domain; Region: ParBc; pfam02195 359786000435 acetoin reductase; Validated; Region: PRK08643 359786000436 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 359786000437 NAD binding site [chemical binding]; other site 359786000438 homotetramer interface [polypeptide binding]; other site 359786000439 homodimer interface [polypeptide binding]; other site 359786000440 active site 359786000441 substrate binding site [chemical binding]; other site 359786000442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 359786000443 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 359786000444 NAD(P) binding site [chemical binding]; other site 359786000445 active site 359786000446 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 359786000447 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 359786000448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 359786000449 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 359786000450 putative ADP-binding pocket [chemical binding]; other site 359786000451 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 359786000452 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 359786000453 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 359786000454 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 359786000455 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 359786000456 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 359786000457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 359786000458 DNA-binding site [nucleotide binding]; DNA binding site 359786000459 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 359786000460 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 359786000461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 359786000462 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 359786000463 intersubunit interface [polypeptide binding]; other site 359786000464 active site 359786000465 catalytic residue [active] 359786000466 phosphopentomutase; Provisional; Region: PRK05362 359786000467 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 359786000468 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 359786000469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786000470 dimer interface [polypeptide binding]; other site 359786000471 conserved gate region; other site 359786000472 putative PBP binding loops; other site 359786000473 ABC-ATPase subunit interface; other site 359786000474 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 359786000475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786000476 dimer interface [polypeptide binding]; other site 359786000477 conserved gate region; other site 359786000478 ABC-ATPase subunit interface; other site 359786000479 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 359786000480 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 359786000481 Walker A/P-loop; other site 359786000482 ATP binding site [chemical binding]; other site 359786000483 Q-loop/lid; other site 359786000484 ABC transporter signature motif; other site 359786000485 Walker B; other site 359786000486 D-loop; other site 359786000487 H-loop/switch region; other site 359786000488 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 359786000489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 359786000490 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 359786000491 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 359786000492 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 359786000493 active site 359786000494 metal binding site [ion binding]; metal-binding site 359786000495 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 359786000496 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 359786000497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786000498 non-specific DNA binding site [nucleotide binding]; other site 359786000499 salt bridge; other site 359786000500 sequence-specific DNA binding site [nucleotide binding]; other site 359786000501 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 359786000502 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 359786000503 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 359786000504 putative catalytic cysteine [active] 359786000505 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 359786000506 putative active site [active] 359786000507 metal binding site [ion binding]; metal-binding site 359786000508 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 359786000509 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 359786000510 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 359786000511 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 359786000512 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 359786000513 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 359786000514 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 359786000515 NAD(P) binding site [chemical binding]; other site 359786000516 homodimer interface [polypeptide binding]; other site 359786000517 substrate binding site [chemical binding]; other site 359786000518 active site 359786000519 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 359786000520 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 359786000521 NAD(P) binding site [chemical binding]; other site 359786000522 homodimer interface [polypeptide binding]; other site 359786000523 substrate binding site [chemical binding]; other site 359786000524 active site 359786000525 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 359786000526 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 359786000527 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 359786000528 putative NAD(P) binding site [chemical binding]; other site 359786000529 active site 359786000530 putative substrate binding site [chemical binding]; other site 359786000531 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 359786000532 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 359786000533 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 359786000534 active site 359786000535 homodimer interface [polypeptide binding]; other site 359786000536 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 359786000537 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 359786000538 trimer interface [polypeptide binding]; other site 359786000539 active site 359786000540 substrate binding site [chemical binding]; other site 359786000541 CoA binding site [chemical binding]; other site 359786000542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 359786000543 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 359786000544 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 359786000545 O-Antigen ligase; Region: Wzy_C; pfam04932 359786000546 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 359786000547 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 359786000548 Bacterial sugar transferase; Region: Bac_transf; pfam02397 359786000549 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 359786000550 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 359786000551 putative NAD(P) binding site [chemical binding]; other site 359786000552 active site 359786000553 putative substrate binding site [chemical binding]; other site 359786000554 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 359786000555 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 359786000556 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 359786000557 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 359786000558 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 359786000559 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 359786000560 active site 359786000561 homodimer interface [polypeptide binding]; other site 359786000562 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 359786000563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 359786000564 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 359786000565 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 359786000566 NAD(P) binding site [chemical binding]; other site 359786000567 catalytic residues [active] 359786000568 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 359786000569 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 359786000570 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 359786000571 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 359786000572 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 359786000573 Walker A/P-loop; other site 359786000574 ATP binding site [chemical binding]; other site 359786000575 Q-loop/lid; other site 359786000576 ABC transporter signature motif; other site 359786000577 Walker B; other site 359786000578 D-loop; other site 359786000579 H-loop/switch region; other site 359786000580 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 359786000581 NMT1-like family; Region: NMT1_2; pfam13379 359786000582 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 359786000583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 359786000584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 359786000585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 359786000586 active site 359786000587 Uncharacterized conserved protein [Function unknown]; Region: COG5609 359786000588 formate dehydrogenase; Provisional; Region: PRK07574 359786000589 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 359786000590 dimerization interface [polypeptide binding]; other site 359786000591 ligand binding site [chemical binding]; other site 359786000592 NAD binding site [chemical binding]; other site 359786000593 catalytic site [active] 359786000594 putative transporter; Provisional; Region: PRK10054 359786000595 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 359786000596 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 359786000597 acyl-activating enzyme (AAE) consensus motif; other site 359786000598 AMP binding site [chemical binding]; other site 359786000599 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 359786000600 Condensation domain; Region: Condensation; pfam00668 359786000601 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 359786000602 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 359786000603 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 359786000604 acyl-activating enzyme (AAE) consensus motif; other site 359786000605 AMP binding site [chemical binding]; other site 359786000606 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 359786000607 thioester reductase domain; Region: Thioester-redct; TIGR01746 359786000608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 359786000609 NAD(P) binding site [chemical binding]; other site 359786000610 active site 359786000611 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 359786000612 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 359786000613 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 359786000614 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 359786000615 nucleotide binding site [chemical binding]; other site 359786000616 N-acetyl-L-glutamate binding site [chemical binding]; other site 359786000617 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 359786000618 heterotetramer interface [polypeptide binding]; other site 359786000619 active site pocket [active] 359786000620 cleavage site 359786000621 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 359786000622 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 359786000623 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 359786000624 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 359786000625 inhibitor-cofactor binding pocket; inhibition site 359786000626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786000627 catalytic residue [active] 359786000628 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 359786000629 Isochorismatase family; Region: Isochorismatase; pfam00857 359786000630 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 359786000631 catalytic triad [active] 359786000632 conserved cis-peptide bond; other site 359786000633 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 359786000634 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 359786000635 dimer interface [polypeptide binding]; other site 359786000636 PYR/PP interface [polypeptide binding]; other site 359786000637 TPP binding site [chemical binding]; other site 359786000638 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 359786000639 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 359786000640 TPP-binding site [chemical binding]; other site 359786000641 dimer interface [polypeptide binding]; other site 359786000642 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 359786000643 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 359786000644 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 359786000645 active site turn [active] 359786000646 phosphorylation site [posttranslational modification] 359786000647 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 359786000648 HPr interaction site; other site 359786000649 glycerol kinase (GK) interaction site [polypeptide binding]; other site 359786000650 active site 359786000651 phosphorylation site [posttranslational modification] 359786000652 Uncharacterized conserved protein [Function unknown]; Region: COG3589 359786000653 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 359786000654 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 359786000655 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 359786000656 putative active site [active] 359786000657 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 359786000658 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 359786000659 active site turn [active] 359786000660 phosphorylation site [posttranslational modification] 359786000661 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 359786000662 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 359786000663 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 359786000664 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 359786000665 putative active site [active] 359786000666 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 359786000667 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 359786000668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 359786000669 ATP binding site [chemical binding]; other site 359786000670 putative Mg++ binding site [ion binding]; other site 359786000671 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 359786000672 HlyD family secretion protein; Region: HlyD_3; pfam13437 359786000673 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 359786000674 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 359786000675 Walker A/P-loop; other site 359786000676 ATP binding site [chemical binding]; other site 359786000677 Q-loop/lid; other site 359786000678 ABC transporter signature motif; other site 359786000679 Walker B; other site 359786000680 D-loop; other site 359786000681 H-loop/switch region; other site 359786000682 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 359786000683 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 359786000684 FtsX-like permease family; Region: FtsX; pfam02687 359786000685 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 359786000686 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 359786000687 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 359786000688 Walker A/P-loop; other site 359786000689 ATP binding site [chemical binding]; other site 359786000690 Q-loop/lid; other site 359786000691 ABC transporter signature motif; other site 359786000692 Walker B; other site 359786000693 D-loop; other site 359786000694 H-loop/switch region; other site 359786000695 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 359786000696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786000697 non-specific DNA binding site [nucleotide binding]; other site 359786000698 salt bridge; other site 359786000699 sequence-specific DNA binding site [nucleotide binding]; other site 359786000700 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 359786000701 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 359786000702 Walker A/P-loop; other site 359786000703 ATP binding site [chemical binding]; other site 359786000704 Q-loop/lid; other site 359786000705 ABC transporter signature motif; other site 359786000706 Walker B; other site 359786000707 D-loop; other site 359786000708 H-loop/switch region; other site 359786000709 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 359786000710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 359786000711 Walker A/P-loop; other site 359786000712 ATP binding site [chemical binding]; other site 359786000713 Q-loop/lid; other site 359786000714 ABC transporter signature motif; other site 359786000715 Walker B; other site 359786000716 D-loop; other site 359786000717 H-loop/switch region; other site 359786000718 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 359786000719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786000720 dimer interface [polypeptide binding]; other site 359786000721 conserved gate region; other site 359786000722 putative PBP binding loops; other site 359786000723 ABC-ATPase subunit interface; other site 359786000724 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 359786000725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786000726 dimer interface [polypeptide binding]; other site 359786000727 conserved gate region; other site 359786000728 ABC-ATPase subunit interface; other site 359786000729 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 359786000730 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 359786000731 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 359786000732 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 359786000733 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 359786000734 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 359786000735 azoreductase; Reviewed; Region: PRK00170 359786000736 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 359786000737 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 359786000738 Peptidase family M23; Region: Peptidase_M23; pfam01551 359786000739 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 359786000740 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 359786000741 Walker A/P-loop; other site 359786000742 ATP binding site [chemical binding]; other site 359786000743 Q-loop/lid; other site 359786000744 ABC transporter signature motif; other site 359786000745 Walker B; other site 359786000746 D-loop; other site 359786000747 H-loop/switch region; other site 359786000748 TOBE domain; Region: TOBE; pfam03459 359786000749 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 359786000750 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 359786000751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786000752 dimer interface [polypeptide binding]; other site 359786000753 conserved gate region; other site 359786000754 ABC-ATPase subunit interface; other site 359786000755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 359786000756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786000757 dimer interface [polypeptide binding]; other site 359786000758 conserved gate region; other site 359786000759 putative PBP binding loops; other site 359786000760 ABC-ATPase subunit interface; other site 359786000761 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 359786000762 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 359786000763 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 359786000764 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 359786000765 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 359786000766 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 359786000767 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 359786000768 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 359786000769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 359786000770 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 359786000771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786000772 putative substrate translocation pore; other site 359786000773 Response regulator receiver domain; Region: Response_reg; pfam00072 359786000774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786000775 active site 359786000776 phosphorylation site [posttranslational modification] 359786000777 intermolecular recognition site; other site 359786000778 dimerization interface [polypeptide binding]; other site 359786000779 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 359786000780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 359786000781 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 359786000782 Histidine kinase; Region: His_kinase; pfam06580 359786000783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786000784 ATP binding site [chemical binding]; other site 359786000785 Mg2+ binding site [ion binding]; other site 359786000786 G-X-G motif; other site 359786000787 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 359786000788 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 359786000789 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 359786000790 Pyruvate formate lyase 1; Region: PFL1; cd01678 359786000791 coenzyme A binding site [chemical binding]; other site 359786000792 active site 359786000793 catalytic residues [active] 359786000794 glycine loop; other site 359786000795 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 359786000796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 359786000797 FeS/SAM binding site; other site 359786000798 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 359786000799 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 359786000800 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 359786000801 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 359786000802 putative active site [active] 359786000803 catalytic site [active] 359786000804 putative metal binding site [ion binding]; other site 359786000805 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 359786000806 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 359786000807 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 359786000808 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 359786000809 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 359786000810 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 359786000811 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 359786000812 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 359786000813 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 359786000814 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 359786000815 dimer interface [polypeptide binding]; other site 359786000816 active site 359786000817 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 359786000818 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 359786000819 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 359786000820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 359786000821 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 359786000822 substrate binding site [chemical binding]; other site 359786000823 oxyanion hole (OAH) forming residues; other site 359786000824 trimer interface [polypeptide binding]; other site 359786000825 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 359786000826 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 359786000827 active site 359786000828 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 359786000829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 359786000830 acyl-activating enzyme (AAE) consensus motif; other site 359786000831 AMP binding site [chemical binding]; other site 359786000832 active site 359786000833 CoA binding site [chemical binding]; other site 359786000834 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 359786000835 Coenzyme A transferase; Region: CoA_trans; smart00882 359786000836 Coenzyme A transferase; Region: CoA_trans; cl17247 359786000837 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 359786000838 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 359786000839 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 359786000840 Uncharacterized conserved protein [Function unknown]; Region: COG3189 359786000841 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 359786000842 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 359786000843 heme-binding site [chemical binding]; other site 359786000844 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 359786000845 FAD binding pocket [chemical binding]; other site 359786000846 FAD binding motif [chemical binding]; other site 359786000847 phosphate binding motif [ion binding]; other site 359786000848 beta-alpha-beta structure motif; other site 359786000849 NAD binding pocket [chemical binding]; other site 359786000850 Heme binding pocket [chemical binding]; other site 359786000851 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 359786000852 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 359786000853 tetramer (dimer of dimers) interface [polypeptide binding]; other site 359786000854 NAD binding site [chemical binding]; other site 359786000855 dimer interface [polypeptide binding]; other site 359786000856 substrate binding site [chemical binding]; other site 359786000857 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 359786000858 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 359786000859 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 359786000860 active site turn [active] 359786000861 phosphorylation site [posttranslational modification] 359786000862 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 359786000863 active site 359786000864 tetramer interface [polypeptide binding]; other site 359786000865 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 359786000866 Mga helix-turn-helix domain; Region: Mga; pfam05043 359786000867 PRD domain; Region: PRD; pfam00874 359786000868 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 359786000869 active site 359786000870 P-loop; other site 359786000871 phosphorylation site [posttranslational modification] 359786000872 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 359786000873 active site 359786000874 phosphorylation site [posttranslational modification] 359786000875 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 359786000876 active site 359786000877 phosphorylation site [posttranslational modification] 359786000878 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 359786000879 active site 359786000880 P-loop; other site 359786000881 phosphorylation site [posttranslational modification] 359786000882 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 359786000883 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 359786000884 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 359786000885 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 359786000886 putative NAD(P) binding site [chemical binding]; other site 359786000887 catalytic Zn binding site [ion binding]; other site 359786000888 structural Zn binding site [ion binding]; other site 359786000889 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 359786000890 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 359786000891 putative NAD(P) binding site [chemical binding]; other site 359786000892 catalytic Zn binding site [ion binding]; other site 359786000893 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 359786000894 substrate binding site; other site 359786000895 dimer interface; other site 359786000896 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 359786000897 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 359786000898 putative NAD(P) binding site [chemical binding]; other site 359786000899 putative catalytic Zn binding site [ion binding]; other site 359786000900 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 359786000901 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 359786000902 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 359786000903 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 359786000904 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 359786000905 substrate binding site; other site 359786000906 dimer interface; other site 359786000907 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 359786000908 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 359786000909 putative NAD(P) binding site [chemical binding]; other site 359786000910 putative catalytic Zn binding site [ion binding]; other site 359786000911 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 359786000912 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 359786000913 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 359786000914 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 359786000915 active site 359786000916 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 359786000917 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 359786000918 Hemerythrin-like domain; Region: Hr-like; cd12108 359786000919 Fe binding site [ion binding]; other site 359786000920 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 359786000921 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 359786000922 Histidine kinase; Region: His_kinase; pfam06580 359786000923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786000924 Mg2+ binding site [ion binding]; other site 359786000925 G-X-G motif; other site 359786000926 two-component response regulator; Provisional; Region: PRK14084 359786000927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786000928 active site 359786000929 phosphorylation site [posttranslational modification] 359786000930 intermolecular recognition site; other site 359786000931 dimerization interface [polypeptide binding]; other site 359786000932 LytTr DNA-binding domain; Region: LytTR; pfam04397 359786000933 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 359786000934 antiholin-like protein LrgB; Provisional; Region: PRK04288 359786000935 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 359786000936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 359786000937 DNA-binding site [nucleotide binding]; DNA binding site 359786000938 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 359786000939 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 359786000940 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 359786000941 HPr interaction site; other site 359786000942 glycerol kinase (GK) interaction site [polypeptide binding]; other site 359786000943 active site 359786000944 phosphorylation site [posttranslational modification] 359786000945 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 359786000946 beta-galactosidase; Region: BGL; TIGR03356 359786000947 Methyltransferase domain; Region: Methyltransf_31; pfam13847 359786000948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786000949 S-adenosylmethionine binding site [chemical binding]; other site 359786000950 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 359786000951 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 359786000952 substrate binding site [chemical binding]; other site 359786000953 dimer interface [polypeptide binding]; other site 359786000954 ATP binding site [chemical binding]; other site 359786000955 D-ribose pyranase; Provisional; Region: PRK11797 359786000956 Sugar transport protein; Region: Sugar_transport; pfam06800 359786000957 Transcriptional regulators [Transcription]; Region: PurR; COG1609 359786000958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 359786000959 DNA binding site [nucleotide binding] 359786000960 domain linker motif; other site 359786000961 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 359786000962 dimerization interface [polypeptide binding]; other site 359786000963 ligand binding site [chemical binding]; other site 359786000964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786000965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786000966 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 359786000967 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 359786000968 active site 359786000969 Surface antigen [General function prediction only]; Region: COG3942 359786000970 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 359786000971 Peptidase family M23; Region: Peptidase_M23; pfam01551 359786000972 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 359786000973 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 359786000974 Walker A/P-loop; other site 359786000975 ATP binding site [chemical binding]; other site 359786000976 Q-loop/lid; other site 359786000977 ABC transporter signature motif; other site 359786000978 Walker B; other site 359786000979 D-loop; other site 359786000980 H-loop/switch region; other site 359786000981 Surface antigen [General function prediction only]; Region: COG3942 359786000982 CHAP domain; Region: CHAP; pfam05257 359786000983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 359786000984 Predicted membrane protein [Function unknown]; Region: COG1511 359786000985 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 359786000986 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 359786000987 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 359786000988 Uncharacterized small protein [Function unknown]; Region: COG5417 359786000989 Predicted membrane protein [Function unknown]; Region: COG4499 359786000990 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 359786000991 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 359786000992 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 359786000993 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 359786000994 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 359786000995 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 359786000996 Uncharacterized conserved protein [Function unknown]; Region: COG5444 359786000997 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 359786000998 Protein of unknown function, DUF600; Region: DUF600; cl04640 359786000999 Protein of unknown function, DUF600; Region: DUF600; cl04640 359786001000 Protein of unknown function, DUF600; Region: DUF600; cl04640 359786001001 Protein of unknown function, DUF600; Region: DUF600; cl04640 359786001002 Protein of unknown function, DUF600; Region: DUF600; cl04640 359786001003 Protein of unknown function, DUF600; Region: DUF600; cl04640 359786001004 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 359786001005 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 359786001006 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 359786001007 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 359786001008 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 359786001009 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 359786001010 FtsX-like permease family; Region: FtsX; pfam02687 359786001011 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 359786001012 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 359786001013 Walker A/P-loop; other site 359786001014 ATP binding site [chemical binding]; other site 359786001015 Q-loop/lid; other site 359786001016 ABC transporter signature motif; other site 359786001017 Walker B; other site 359786001018 D-loop; other site 359786001019 H-loop/switch region; other site 359786001020 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 359786001021 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 359786001022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786001023 non-specific DNA binding site [nucleotide binding]; other site 359786001024 salt bridge; other site 359786001025 sequence-specific DNA binding site [nucleotide binding]; other site 359786001026 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 359786001027 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 359786001028 substrate binding site [chemical binding]; other site 359786001029 ATP binding site [chemical binding]; other site 359786001030 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 359786001031 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 359786001032 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 359786001033 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 359786001034 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 359786001035 putative transporter; Provisional; Region: PRK10484 359786001036 Na binding site [ion binding]; other site 359786001037 N-acetylneuraminate lyase; Provisional; Region: PRK04147 359786001038 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 359786001039 inhibitor site; inhibition site 359786001040 active site 359786001041 dimer interface [polypeptide binding]; other site 359786001042 catalytic residue [active] 359786001043 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 359786001044 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 359786001045 nucleotide binding site [chemical binding]; other site 359786001046 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 359786001047 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 359786001048 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 359786001049 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 359786001050 putative active site [active] 359786001051 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 359786001052 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 359786001053 putative active site cavity [active] 359786001054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 359786001055 Nucleoside recognition; Region: Gate; pfam07670 359786001056 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 359786001057 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 359786001058 PGAP1-like protein; Region: PGAP1; pfam07819 359786001059 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 359786001060 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 359786001061 Int/Topo IB signature motif; other site 359786001062 carbonate dehydratase; Region: PLN02296 359786001063 Domain of unknown function (DUF955); Region: DUF955; pfam06114 359786001064 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 359786001065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786001066 non-specific DNA binding site [nucleotide binding]; other site 359786001067 salt bridge; other site 359786001068 sequence-specific DNA binding site [nucleotide binding]; other site 359786001069 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 359786001070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786001071 non-specific DNA binding site [nucleotide binding]; other site 359786001072 salt bridge; other site 359786001073 sequence-specific DNA binding site [nucleotide binding]; other site 359786001074 Phage anti-repressor protein [Transcription]; Region: COG3561 359786001075 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 359786001076 Homeodomain-like domain; Region: HTH_23; pfam13384 359786001077 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 359786001078 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 359786001079 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 359786001080 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 359786001081 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 359786001082 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 359786001083 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 359786001084 dimer interface [polypeptide binding]; other site 359786001085 ssDNA binding site [nucleotide binding]; other site 359786001086 tetramer (dimer of dimers) interface [polypeptide binding]; other site 359786001087 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 359786001088 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 359786001089 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 359786001090 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 359786001091 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 359786001092 YopX protein; Region: YopX; pfam09643 359786001093 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 359786001094 dUTPase; Region: dUTPase_2; pfam08761 359786001095 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 359786001096 active site 359786001097 homodimer interface [polypeptide binding]; other site 359786001098 metal binding site [ion binding]; metal-binding site 359786001099 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 359786001100 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 359786001101 Transcriptional activator RinB; Region: RinB; pfam06116 359786001102 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 359786001103 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 359786001104 Terminase small subunit; Region: Terminase_2; cl01513 359786001105 phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547 359786001106 Terminase-like family; Region: Terminase_6; pfam03237 359786001107 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 359786001108 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 359786001109 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 359786001110 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 359786001111 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 359786001112 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 359786001113 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 359786001114 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 359786001115 Phage major tail protein, TP901-1; Region: PhageMaj_Tail; cl11463 359786001116 Phage protein; Region: DUF3647; pfam12363 359786001117 Phage-related protein [Function unknown]; Region: COG5412 359786001118 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 359786001119 Phage tail protein; Region: Sipho_tail; pfam05709 359786001120 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 359786001121 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 359786001122 active site 359786001123 catalytic triad [active] 359786001124 oxyanion hole [active] 359786001125 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 359786001126 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 359786001127 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 359786001128 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 359786001129 CHAP domain; Region: CHAP; pfam05257 359786001130 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 359786001131 Lysozyme subfamily 2; Region: LYZ2; smart00047 359786001132 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 359786001133 Bacteriophage holin; Region: Phage_holin_1; pfam04531 359786001134 CHAP domain; Region: CHAP; pfam05257 359786001135 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 359786001136 amidase catalytic site [active] 359786001137 Zn binding residues [ion binding]; other site 359786001138 substrate binding site [chemical binding]; other site 359786001139 Bacterial SH3 domain; Region: SH3_5; pfam08460 359786001140 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 359786001141 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 359786001142 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 359786001143 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 359786001144 putative active site [active] 359786001145 putative FMN binding site [chemical binding]; other site 359786001146 putative substrate binding site [chemical binding]; other site 359786001147 putative catalytic residue [active] 359786001148 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 359786001149 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 359786001150 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 359786001151 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 359786001152 lipoyl attachment site [posttranslational modification]; other site 359786001153 Replication protein C N-terminal domain; Region: RP-C; pfam03428 359786001154 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 359786001155 putative ADP-ribose binding site [chemical binding]; other site 359786001156 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 359786001157 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 359786001158 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 359786001159 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 359786001160 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 359786001161 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 359786001162 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 359786001163 NADP binding site [chemical binding]; other site 359786001164 putative substrate binding site [chemical binding]; other site 359786001165 active site 359786001166 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 359786001167 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 359786001168 active site 359786001169 P-loop; other site 359786001170 phosphorylation site [posttranslational modification] 359786001171 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 359786001172 active site 359786001173 phosphorylation site [posttranslational modification] 359786001174 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 359786001175 HTH domain; Region: HTH_11; pfam08279 359786001176 HTH domain; Region: HTH_11; pfam08279 359786001177 PRD domain; Region: PRD; pfam00874 359786001178 PRD domain; Region: PRD; pfam00874 359786001179 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 359786001180 active site 359786001181 P-loop; other site 359786001182 phosphorylation site [posttranslational modification] 359786001183 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 359786001184 active site 359786001185 phosphorylation site [posttranslational modification] 359786001186 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 359786001187 MarR family; Region: MarR_2; pfam12802 359786001188 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 359786001189 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 359786001190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 359786001191 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 359786001192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786001193 putative substrate translocation pore; other site 359786001194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786001195 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 359786001196 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 359786001197 Zn binding site [ion binding]; other site 359786001198 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 359786001199 Zn binding site [ion binding]; other site 359786001200 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 359786001201 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 359786001202 Predicted flavoprotein [General function prediction only]; Region: COG0431 359786001203 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 359786001204 Predicted membrane protein [Function unknown]; Region: COG2855 359786001205 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 359786001206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 359786001207 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 359786001208 Imelysin; Region: Peptidase_M75; pfam09375 359786001209 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 359786001210 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 359786001211 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 359786001212 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 359786001213 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 359786001214 Phage envelope protein [General function prediction only]; Region: COG5562 359786001215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786001216 non-specific DNA binding site [nucleotide binding]; other site 359786001217 salt bridge; other site 359786001218 sequence-specific DNA binding site [nucleotide binding]; other site 359786001219 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 359786001220 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 359786001221 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 359786001222 Walker A/P-loop; other site 359786001223 ATP binding site [chemical binding]; other site 359786001224 Q-loop/lid; other site 359786001225 ABC transporter signature motif; other site 359786001226 Walker B; other site 359786001227 D-loop; other site 359786001228 H-loop/switch region; other site 359786001229 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 359786001230 Predicted membrane protein [Function unknown]; Region: COG4292 359786001231 putative acyltransferase; Provisional; Region: PRK05790 359786001232 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 359786001233 dimer interface [polypeptide binding]; other site 359786001234 active site 359786001235 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 359786001236 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 359786001237 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 359786001238 THF binding site; other site 359786001239 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 359786001240 substrate binding site [chemical binding]; other site 359786001241 THF binding site; other site 359786001242 zinc-binding site [ion binding]; other site 359786001243 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 359786001244 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 359786001245 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 359786001246 FAD binding site [chemical binding]; other site 359786001247 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 359786001248 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 359786001249 homodimer interface [polypeptide binding]; other site 359786001250 substrate-cofactor binding pocket; other site 359786001251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786001252 catalytic residue [active] 359786001253 cystathionine gamma-synthase; Reviewed; Region: PRK08247 359786001254 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 359786001255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 359786001256 catalytic residue [active] 359786001257 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 359786001258 ParB-like nuclease domain; Region: ParB; smart00470 359786001259 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 359786001260 Mechanosensitive ion channel; Region: MS_channel; pfam00924 359786001261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 359786001262 GTP-binding protein YchF; Reviewed; Region: PRK09601 359786001263 YchF GTPase; Region: YchF; cd01900 359786001264 G1 box; other site 359786001265 GTP/Mg2+ binding site [chemical binding]; other site 359786001266 Switch I region; other site 359786001267 G2 box; other site 359786001268 Switch II region; other site 359786001269 G3 box; other site 359786001270 G4 box; other site 359786001271 G5 box; other site 359786001272 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 359786001273 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 359786001274 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 359786001275 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 359786001276 dimer interface [polypeptide binding]; other site 359786001277 ssDNA binding site [nucleotide binding]; other site 359786001278 tetramer (dimer of dimers) interface [polypeptide binding]; other site 359786001279 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 359786001280 Abi-like protein; Region: Abi_2; pfam07751 359786001281 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 359786001282 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 359786001284 Predicted membrane protein [Function unknown]; Region: COG3212 359786001285 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 359786001286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 359786001287 non-specific DNA binding site [nucleotide binding]; other site 359786001288 salt bridge; other site 359786001289 sequence-specific DNA binding site [nucleotide binding]; other site 359786001290 Predicted membrane protein [Function unknown]; Region: COG2261 359786001291 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 359786001292 catalytic core [active] 359786001293 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 359786001294 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 359786001295 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 359786001296 catalytic residue [active] 359786001297 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 359786001298 catalytic residues [active] 359786001299 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 359786001300 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786001301 peroxiredoxin; Region: AhpC; TIGR03137 359786001302 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 359786001303 dimer interface [polypeptide binding]; other site 359786001304 decamer (pentamer of dimers) interface [polypeptide binding]; other site 359786001305 catalytic triad [active] 359786001306 peroxidatic and resolving cysteines [active] 359786001307 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 359786001308 dimer interface [polypeptide binding]; other site 359786001309 FMN binding site [chemical binding]; other site 359786001310 NADPH bind site [chemical binding]; other site 359786001311 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 359786001312 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 359786001313 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 359786001314 active site 359786001315 xanthine permease; Region: pbuX; TIGR03173 359786001316 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 359786001317 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 359786001318 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 359786001319 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 359786001320 active site 359786001321 GMP synthase; Reviewed; Region: guaA; PRK00074 359786001322 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 359786001323 AMP/PPi binding site [chemical binding]; other site 359786001324 candidate oxyanion hole; other site 359786001325 catalytic triad [active] 359786001326 potential glutamine specificity residues [chemical binding]; other site 359786001327 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 359786001328 ATP Binding subdomain [chemical binding]; other site 359786001329 Ligand Binding sites [chemical binding]; other site 359786001330 Dimerization subdomain; other site 359786001331 PemK-like protein; Region: PemK; pfam02452 359786001332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 359786001333 Transposase; Region: HTH_Tnp_1; cl17663 359786001334 Predicted membrane protein [Function unknown]; Region: COG3759 359786001335 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 359786001336 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 359786001337 NADP binding site [chemical binding]; other site 359786001338 superantigen-like protein; Reviewed; Region: PRK13037 359786001339 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 359786001340 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001341 superantigen-like protein; Reviewed; Region: PRK13041 359786001342 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 359786001343 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001344 superantigen-like protein; Reviewed; Region: PRK13335 359786001345 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 359786001346 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001347 superantigen-like protein; Reviewed; Region: PRK13042 359786001348 Mucin-like glycoprotein; Region: Mucin; pfam01456 359786001349 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 359786001350 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001351 superantigen-like protein 5; Reviewed; Region: PRK13035 359786001352 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 359786001353 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001354 superantigen-like protein 7; Reviewed; Region: PRK13346 359786001355 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 359786001356 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001357 superantigen-like protein; Reviewed; Region: PRK13039 359786001358 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 359786001359 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001360 superantigen-like protein; Reviewed; Region: PRK13345 359786001361 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 359786001362 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001363 superantigen-like protein 5; Reviewed; Region: PRK13035 359786001364 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 359786001365 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001366 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 359786001367 HsdM N-terminal domain; Region: HsdM_N; pfam12161 359786001368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786001369 S-adenosylmethionine binding site [chemical binding]; other site 359786001370 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 359786001371 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 359786001372 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 359786001373 superantigen-like protein; Reviewed; Region: PRK13036 359786001374 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 359786001375 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786001376 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786001377 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786001378 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786001379 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786001380 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786001381 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786001382 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786001383 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786001384 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786001385 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 359786001386 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 359786001387 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 359786001388 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 359786001389 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 359786001390 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 359786001391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 359786001392 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 359786001393 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 359786001394 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 359786001395 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 359786001396 active site 359786001397 Esterase/lipase [General function prediction only]; Region: COG1647 359786001398 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 359786001399 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 359786001400 Na2 binding site [ion binding]; other site 359786001401 putative substrate binding site 1 [chemical binding]; other site 359786001402 Na binding site 1 [ion binding]; other site 359786001403 putative substrate binding site 2 [chemical binding]; other site 359786001404 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 359786001405 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 359786001406 dimer interface [polypeptide binding]; other site 359786001407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786001408 catalytic residue [active] 359786001409 cystathionine beta-lyase; Provisional; Region: PRK07671 359786001410 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 359786001411 homodimer interface [polypeptide binding]; other site 359786001412 substrate-cofactor binding pocket; other site 359786001413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786001414 catalytic residue [active] 359786001415 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 359786001416 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 359786001417 Walker A/P-loop; other site 359786001418 ATP binding site [chemical binding]; other site 359786001419 Q-loop/lid; other site 359786001420 ABC transporter signature motif; other site 359786001421 Walker B; other site 359786001422 D-loop; other site 359786001423 H-loop/switch region; other site 359786001424 NIL domain; Region: NIL; pfam09383 359786001425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786001426 dimer interface [polypeptide binding]; other site 359786001427 conserved gate region; other site 359786001428 ABC-ATPase subunit interface; other site 359786001429 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 359786001430 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 359786001431 LysM domain; Region: LysM; pfam01476 359786001432 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 359786001433 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 359786001434 Surface antigen [General function prediction only]; Region: COG3942 359786001435 CHAP domain; Region: CHAP; pfam05257 359786001436 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 359786001437 nudix motif; other site 359786001438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786001439 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 359786001440 Coenzyme A binding pocket [chemical binding]; other site 359786001441 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 359786001442 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 359786001443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 359786001444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 359786001445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 359786001446 dimerization interface [polypeptide binding]; other site 359786001447 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 359786001448 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 359786001449 active site 359786001450 dimer interface [polypeptide binding]; other site 359786001451 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 359786001452 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 359786001453 active site 359786001454 FMN binding site [chemical binding]; other site 359786001455 substrate binding site [chemical binding]; other site 359786001456 3Fe-4S cluster binding site [ion binding]; other site 359786001457 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 359786001458 domain interface; other site 359786001459 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 359786001460 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 359786001461 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 359786001462 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 359786001463 active site turn [active] 359786001464 phosphorylation site [posttranslational modification] 359786001465 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 359786001466 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 359786001467 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 359786001468 Ca binding site [ion binding]; other site 359786001469 active site 359786001470 catalytic site [active] 359786001471 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 359786001472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 359786001473 DNA-binding site [nucleotide binding]; DNA binding site 359786001474 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 359786001475 UTRA domain; Region: UTRA; pfam07702 359786001476 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 359786001477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786001478 Coenzyme A binding pocket [chemical binding]; other site 359786001479 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 359786001480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786001481 Walker A motif; other site 359786001482 ATP binding site [chemical binding]; other site 359786001483 Walker B motif; other site 359786001484 arginine finger; other site 359786001485 hypothetical protein; Validated; Region: PRK00153 359786001486 recombination protein RecR; Reviewed; Region: recR; PRK00076 359786001487 RecR protein; Region: RecR; pfam02132 359786001488 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 359786001489 putative active site [active] 359786001490 putative metal-binding site [ion binding]; other site 359786001491 tetramer interface [polypeptide binding]; other site 359786001492 5S ribosomal RNA region; weak similarity to 5S 359786001493 5S ribosomal RNA region; weak similarity to 5S 359786001494 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 359786001495 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 359786001496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 359786001497 catalytic residue [active] 359786001498 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 359786001499 thymidylate kinase; Validated; Region: tmk; PRK00698 359786001500 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 359786001501 TMP-binding site; other site 359786001502 ATP-binding site [chemical binding]; other site 359786001503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 359786001504 DNA polymerase III subunit delta'; Validated; Region: PRK08058 359786001505 DNA polymerase III subunit delta'; Validated; Region: PRK08485 359786001506 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 359786001507 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 359786001508 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 359786001509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786001510 S-adenosylmethionine binding site [chemical binding]; other site 359786001511 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 359786001512 GIY-YIG motif/motif A; other site 359786001513 putative active site [active] 359786001514 putative metal binding site [ion binding]; other site 359786001515 Predicted methyltransferases [General function prediction only]; Region: COG0313 359786001516 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 359786001517 putative SAM binding site [chemical binding]; other site 359786001518 putative homodimer interface [polypeptide binding]; other site 359786001519 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 359786001520 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 359786001521 active site 359786001522 HIGH motif; other site 359786001523 KMSKS motif; other site 359786001524 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 359786001525 tRNA binding surface [nucleotide binding]; other site 359786001526 anticodon binding site; other site 359786001527 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 359786001528 dimer interface [polypeptide binding]; other site 359786001529 putative tRNA-binding site [nucleotide binding]; other site 359786001530 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 359786001531 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 359786001532 active site 359786001533 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 359786001534 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 359786001535 putative active site [active] 359786001536 putative metal binding site [ion binding]; other site 359786001537 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 359786001538 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 359786001539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786001540 S-adenosylmethionine binding site [chemical binding]; other site 359786001541 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 359786001542 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 359786001543 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 359786001544 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 359786001545 pur operon repressor; Provisional; Region: PRK09213 359786001546 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 359786001547 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 359786001548 active site 359786001549 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 359786001550 homotrimer interaction site [polypeptide binding]; other site 359786001551 putative active site [active] 359786001552 regulatory protein SpoVG; Reviewed; Region: PRK13259 359786001553 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 359786001554 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 359786001555 Substrate binding site; other site 359786001556 Mg++ binding site; other site 359786001557 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 359786001558 active site 359786001559 substrate binding site [chemical binding]; other site 359786001560 CoA binding site [chemical binding]; other site 359786001561 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 359786001562 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 359786001563 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 359786001564 active site 359786001565 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 359786001566 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 359786001567 5S rRNA interface [nucleotide binding]; other site 359786001568 CTC domain interface [polypeptide binding]; other site 359786001569 L16 interface [polypeptide binding]; other site 359786001570 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 359786001571 putative active site [active] 359786001572 catalytic residue [active] 359786001573 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 359786001574 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 359786001575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 359786001576 ATP binding site [chemical binding]; other site 359786001577 putative Mg++ binding site [ion binding]; other site 359786001578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 359786001579 nucleotide binding region [chemical binding]; other site 359786001580 ATP-binding site [chemical binding]; other site 359786001581 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 359786001582 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 359786001583 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 359786001584 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 359786001585 putative SAM binding site [chemical binding]; other site 359786001586 putative homodimer interface [polypeptide binding]; other site 359786001587 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 359786001588 homodimer interface [polypeptide binding]; other site 359786001589 metal binding site [ion binding]; metal-binding site 359786001590 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 359786001591 RNA binding surface [nucleotide binding]; other site 359786001592 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 359786001593 Septum formation initiator; Region: DivIC; pfam04977 359786001594 hypothetical protein; Provisional; Region: PRK08582 359786001595 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 359786001596 RNA binding site [nucleotide binding]; other site 359786001597 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 359786001598 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 359786001599 Ligand Binding Site [chemical binding]; other site 359786001600 TilS substrate C-terminal domain; Region: TilS_C; smart00977 359786001601 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 359786001602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 359786001603 active site 359786001604 FtsH Extracellular; Region: FtsH_ext; pfam06480 359786001605 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 359786001606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786001607 Walker A motif; other site 359786001608 ATP binding site [chemical binding]; other site 359786001609 Walker B motif; other site 359786001610 arginine finger; other site 359786001611 Peptidase family M41; Region: Peptidase_M41; pfam01434 359786001612 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 359786001613 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 359786001614 dimerization interface [polypeptide binding]; other site 359786001615 domain crossover interface; other site 359786001616 redox-dependent activation switch; other site 359786001617 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 359786001618 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 359786001619 dimer interface [polypeptide binding]; other site 359786001620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786001621 catalytic residue [active] 359786001622 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 359786001623 dihydropteroate synthase; Region: DHPS; TIGR01496 359786001624 substrate binding pocket [chemical binding]; other site 359786001625 dimer interface [polypeptide binding]; other site 359786001626 inhibitor binding site; inhibition site 359786001627 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 359786001628 homooctamer interface [polypeptide binding]; other site 359786001629 active site 359786001630 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 359786001631 catalytic center binding site [active] 359786001632 ATP binding site [chemical binding]; other site 359786001633 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 359786001634 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 359786001635 dimer interface [polypeptide binding]; other site 359786001636 putative anticodon binding site; other site 359786001637 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 359786001638 motif 1; other site 359786001639 active site 359786001640 motif 2; other site 359786001641 motif 3; other site 359786001642 5S ribosomal RNA region; weak similarity to 5S 359786001643 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 359786001644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 359786001645 DNA-binding site [nucleotide binding]; DNA binding site 359786001646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 359786001647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786001648 homodimer interface [polypeptide binding]; other site 359786001649 catalytic residue [active] 359786001650 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 359786001651 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 359786001652 active site 359786001653 multimer interface [polypeptide binding]; other site 359786001654 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 359786001655 predicted active site [active] 359786001656 catalytic triad [active] 359786001657 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 359786001658 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 359786001659 Nucleoside recognition; Region: Gate; pfam07670 359786001660 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 359786001661 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 359786001662 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 359786001663 UvrB/uvrC motif; Region: UVR; pfam02151 359786001664 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 359786001665 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 359786001666 ADP binding site [chemical binding]; other site 359786001667 phosphagen binding site; other site 359786001668 substrate specificity loop; other site 359786001669 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 359786001670 Clp amino terminal domain; Region: Clp_N; pfam02861 359786001671 Clp amino terminal domain; Region: Clp_N; pfam02861 359786001672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786001673 Walker A motif; other site 359786001674 ATP binding site [chemical binding]; other site 359786001675 Walker B motif; other site 359786001676 arginine finger; other site 359786001677 UvrB/uvrC motif; Region: UVR; pfam02151 359786001678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786001679 Walker A motif; other site 359786001680 ATP binding site [chemical binding]; other site 359786001681 Walker B motif; other site 359786001682 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 359786001683 DNA repair protein RadA; Provisional; Region: PRK11823 359786001684 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 359786001685 Walker A motif/ATP binding site; other site 359786001686 ATP binding site [chemical binding]; other site 359786001687 Walker B motif; other site 359786001688 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 359786001689 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 359786001690 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 359786001691 putative active site [active] 359786001692 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 359786001693 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 359786001694 active site 359786001695 HIGH motif; other site 359786001696 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 359786001697 active site 359786001698 KMSKS motif; other site 359786001699 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 359786001700 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 359786001701 trimer interface [polypeptide binding]; other site 359786001702 active site 359786001703 substrate binding site [chemical binding]; other site 359786001704 CoA binding site [chemical binding]; other site 359786001705 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 359786001706 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 359786001707 active site 359786001708 HIGH motif; other site 359786001709 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 359786001710 KMSKS motif; other site 359786001711 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 359786001712 tRNA binding surface [nucleotide binding]; other site 359786001713 anticodon binding site; other site 359786001714 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 359786001715 active site 359786001716 dimerization interface [polypeptide binding]; other site 359786001717 metal binding site [ion binding]; metal-binding site 359786001718 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 359786001719 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 359786001720 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 359786001721 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 359786001722 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 359786001723 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 359786001724 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 359786001725 DNA binding residues [nucleotide binding] 359786001726 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 359786001727 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 359786001728 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 359786001729 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 359786001730 putative homodimer interface [polypeptide binding]; other site 359786001731 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 359786001732 heterodimer interface [polypeptide binding]; other site 359786001733 homodimer interface [polypeptide binding]; other site 359786001734 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 359786001735 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 359786001736 23S rRNA interface [nucleotide binding]; other site 359786001737 L7/L12 interface [polypeptide binding]; other site 359786001738 putative thiostrepton binding site; other site 359786001739 L25 interface [polypeptide binding]; other site 359786001740 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 359786001741 mRNA/rRNA interface [nucleotide binding]; other site 359786001742 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 359786001743 23S rRNA interface [nucleotide binding]; other site 359786001744 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 359786001745 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 359786001746 peripheral dimer interface [polypeptide binding]; other site 359786001747 core dimer interface [polypeptide binding]; other site 359786001748 L10 interface [polypeptide binding]; other site 359786001749 L11 interface [polypeptide binding]; other site 359786001750 putative EF-Tu interaction site [polypeptide binding]; other site 359786001751 putative EF-G interaction site [polypeptide binding]; other site 359786001752 Methyltransferase domain; Region: Methyltransf_31; pfam13847 359786001753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786001754 S-adenosylmethionine binding site [chemical binding]; other site 359786001755 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 359786001756 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 359786001757 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 359786001758 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 359786001759 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 359786001760 RPB10 interaction site [polypeptide binding]; other site 359786001761 RPB1 interaction site [polypeptide binding]; other site 359786001762 RPB11 interaction site [polypeptide binding]; other site 359786001763 RPB3 interaction site [polypeptide binding]; other site 359786001764 RPB12 interaction site [polypeptide binding]; other site 359786001765 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 359786001766 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 359786001767 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 359786001768 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 359786001769 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 359786001770 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 359786001771 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 359786001772 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 359786001773 G-loop; other site 359786001774 DNA binding site [nucleotide binding] 359786001775 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 359786001776 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 359786001777 S17 interaction site [polypeptide binding]; other site 359786001778 S8 interaction site; other site 359786001779 16S rRNA interaction site [nucleotide binding]; other site 359786001780 streptomycin interaction site [chemical binding]; other site 359786001781 23S rRNA interaction site [nucleotide binding]; other site 359786001782 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 359786001783 30S ribosomal protein S7; Validated; Region: PRK05302 359786001784 elongation factor G; Reviewed; Region: PRK00007 359786001785 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 359786001786 G1 box; other site 359786001787 putative GEF interaction site [polypeptide binding]; other site 359786001788 GTP/Mg2+ binding site [chemical binding]; other site 359786001789 Switch I region; other site 359786001790 G2 box; other site 359786001791 G3 box; other site 359786001792 Switch II region; other site 359786001793 G4 box; other site 359786001794 G5 box; other site 359786001795 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 359786001796 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 359786001797 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 359786001798 elongation factor Tu; Reviewed; Region: PRK00049 359786001799 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 359786001800 G1 box; other site 359786001801 GEF interaction site [polypeptide binding]; other site 359786001802 GTP/Mg2+ binding site [chemical binding]; other site 359786001803 Switch I region; other site 359786001804 G2 box; other site 359786001805 G3 box; other site 359786001806 Switch II region; other site 359786001807 G4 box; other site 359786001808 G5 box; other site 359786001809 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 359786001810 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 359786001811 Antibiotic Binding Site [chemical binding]; other site 359786001812 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 359786001813 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 359786001814 metal binding site [ion binding]; metal-binding site 359786001815 dimer interface [polypeptide binding]; other site 359786001816 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 359786001817 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 359786001818 substrate-cofactor binding pocket; other site 359786001819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786001820 catalytic residue [active] 359786001821 chaperone protein HchA; Provisional; Region: PRK04155 359786001822 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 359786001823 dimer interface [polypeptide binding]; other site 359786001824 metal binding site [ion binding]; metal-binding site 359786001825 potential oxyanion hole; other site 359786001826 potential catalytic triad [active] 359786001827 conserved cys residue [active] 359786001828 ribulokinase; Provisional; Region: PRK04123 359786001829 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 359786001830 N- and C-terminal domain interface [polypeptide binding]; other site 359786001831 active site 359786001832 MgATP binding site [chemical binding]; other site 359786001833 catalytic site [active] 359786001834 metal binding site [ion binding]; metal-binding site 359786001835 carbohydrate binding site [chemical binding]; other site 359786001836 homodimer interface [polypeptide binding]; other site 359786001837 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 359786001838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 359786001839 NAD(P) binding site [chemical binding]; other site 359786001840 active site 359786001841 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 359786001842 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 359786001843 homodimer interface [polypeptide binding]; other site 359786001844 substrate-cofactor binding pocket; other site 359786001845 catalytic residue [active] 359786001846 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 359786001847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786001848 motif II; other site 359786001849 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 359786001850 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 359786001851 Substrate-binding site [chemical binding]; other site 359786001852 Substrate specificity [chemical binding]; other site 359786001853 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 359786001854 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 359786001855 Substrate-binding site [chemical binding]; other site 359786001856 Substrate specificity [chemical binding]; other site 359786001857 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 359786001858 nucleoside/Zn binding site; other site 359786001859 dimer interface [polypeptide binding]; other site 359786001860 catalytic motif [active] 359786001861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786001862 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 359786001863 active site 359786001864 motif I; other site 359786001865 motif II; other site 359786001866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786001867 Predicted flavoprotein [General function prediction only]; Region: COG0431 359786001868 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 359786001869 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786001870 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 359786001871 Cna protein B-type domain; Region: Cna_B; pfam05738 359786001872 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 359786001873 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786001874 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 359786001875 Cna protein B-type domain; Region: Cna_B; pfam05738 359786001876 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 359786001877 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 359786001878 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 359786001879 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 359786001880 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786001881 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 359786001882 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 359786001883 Cna protein B-type domain; Region: Cna_B; pfam05738 359786001884 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 359786001885 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 359786001886 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 359786001887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 359786001888 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 359786001889 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 359786001890 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 359786001891 putative GTP cyclohydrolase; Provisional; Region: PRK13674 359786001892 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 359786001893 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 359786001894 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 359786001895 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 359786001896 active site 359786001897 trimer interface [polypeptide binding]; other site 359786001898 allosteric site; other site 359786001899 active site lid [active] 359786001900 hexamer (dimer of trimers) interface [polypeptide binding]; other site 359786001901 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 359786001902 active site 359786001903 dimer interface [polypeptide binding]; other site 359786001904 magnesium binding site [ion binding]; other site 359786001905 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 359786001906 tetramer interface [polypeptide binding]; other site 359786001907 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 359786001908 active site 359786001909 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 359786001910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786001911 motif II; other site 359786001912 proline/glycine betaine transporter; Provisional; Region: PRK10642 359786001913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786001914 putative substrate translocation pore; other site 359786001915 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 359786001916 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 359786001917 acyl-activating enzyme (AAE) consensus motif; other site 359786001918 AMP binding site [chemical binding]; other site 359786001919 active site 359786001920 CoA binding site [chemical binding]; other site 359786001921 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 359786001922 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 359786001923 dimer interface [polypeptide binding]; other site 359786001924 active site 359786001925 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 359786001926 dimer interface [polypeptide binding]; other site 359786001927 substrate binding site [chemical binding]; other site 359786001928 ATP binding site [chemical binding]; other site 359786001929 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 359786001930 ligand binding site [chemical binding]; other site 359786001931 active site 359786001932 UGI interface [polypeptide binding]; other site 359786001933 catalytic site [active] 359786001934 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 359786001935 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 359786001936 Uncharacterized conserved protein [Function unknown]; Region: COG3610 359786001937 Uncharacterized conserved protein [Function unknown]; Region: COG2966 359786001938 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 359786001939 putative heme peroxidase; Provisional; Region: PRK12276 359786001940 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 359786001941 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 359786001942 mevalonate kinase; Region: mevalon_kin; TIGR00549 359786001943 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 359786001944 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 359786001945 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 359786001946 diphosphomevalonate decarboxylase; Region: PLN02407 359786001947 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 359786001948 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 359786001949 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 359786001950 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 359786001951 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 359786001952 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 359786001953 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786001954 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 359786001955 Predicted transcriptional regulator [Transcription]; Region: COG1959 359786001956 Transcriptional regulator; Region: Rrf2; pfam02082 359786001957 LXG domain of WXG superfamily; Region: LXG; pfam04740 359786001958 Protein of unknown function (DUF443); Region: DUF443; pfam04276 359786001959 Protein of unknown function (DUF443); Region: DUF443; pfam04276 359786001960 Protein of unknown function (DUF443); Region: DUF443; pfam04276 359786001961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 359786001962 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 359786001963 active site 359786001964 catalytic tetrad [active] 359786001965 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 359786001966 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 359786001967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 359786001968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786001969 Coenzyme A binding pocket [chemical binding]; other site 359786001970 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 359786001971 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 359786001972 Zn2+ binding site [ion binding]; other site 359786001973 Mg2+ binding site [ion binding]; other site 359786001974 YwhD family; Region: YwhD; pfam08741 359786001975 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 359786001976 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 359786001977 NAD binding site [chemical binding]; other site 359786001978 substrate binding site [chemical binding]; other site 359786001979 catalytic Zn binding site [ion binding]; other site 359786001980 tetramer interface [polypeptide binding]; other site 359786001981 structural Zn binding site [ion binding]; other site 359786001982 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 359786001983 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 359786001984 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 359786001985 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 359786001986 active site 359786001987 HIGH motif; other site 359786001988 KMSK motif region; other site 359786001989 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 359786001990 tRNA binding surface [nucleotide binding]; other site 359786001991 anticodon binding site; other site 359786001992 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 359786001993 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 359786001994 minor groove reading motif; other site 359786001995 helix-hairpin-helix signature motif; other site 359786001996 substrate binding pocket [chemical binding]; other site 359786001997 active site 359786001998 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 359786001999 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 359786002000 putative binding site residues; other site 359786002001 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 359786002002 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786002003 ABC-ATPase subunit interface; other site 359786002004 dimer interface [polypeptide binding]; other site 359786002005 putative PBP binding regions; other site 359786002006 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 359786002007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786002008 motif II; other site 359786002009 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 359786002010 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 359786002011 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 359786002012 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 359786002013 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786002014 Transcriptional regulators [Transcription]; Region: MarR; COG1846 359786002015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 359786002016 Protein of unknown function, DUF606; Region: DUF606; pfam04657 359786002017 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 359786002018 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 359786002019 active site 359786002020 DNA binding site [nucleotide binding] 359786002021 Int/Topo IB signature motif; other site 359786002022 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 359786002023 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 359786002024 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 359786002025 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 359786002026 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 359786002027 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 359786002028 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 359786002029 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 359786002030 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 359786002031 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 359786002032 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 359786002033 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 359786002034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 359786002035 Transposase; Region: DDE_Tnp_ISL3; pfam01610 359786002036 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 359786002037 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 359786002038 metal binding site [ion binding]; metal-binding site 359786002039 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 359786002040 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786002041 ABC-ATPase subunit interface; other site 359786002042 dimer interface [polypeptide binding]; other site 359786002043 putative PBP binding regions; other site 359786002044 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 359786002045 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 359786002046 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 359786002047 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 359786002048 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 359786002049 FeoA domain; Region: FeoA; pfam04023 359786002050 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 359786002051 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 359786002052 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 359786002053 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 359786002054 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 359786002055 Walker A/P-loop; other site 359786002056 ATP binding site [chemical binding]; other site 359786002057 Q-loop/lid; other site 359786002058 ABC transporter signature motif; other site 359786002059 Walker B; other site 359786002060 D-loop; other site 359786002061 H-loop/switch region; other site 359786002062 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 359786002063 ABC-2 type transporter; Region: ABC2_membrane; cl17235 359786002064 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 359786002065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 359786002066 active site 359786002067 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 359786002068 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 359786002069 active site 359786002070 nucleotide binding site [chemical binding]; other site 359786002071 HIGH motif; other site 359786002072 KMSKS motif; other site 359786002073 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 359786002074 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 359786002075 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 359786002076 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 359786002077 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 359786002078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786002079 Walker A/P-loop; other site 359786002080 ATP binding site [chemical binding]; other site 359786002081 Q-loop/lid; other site 359786002082 ABC transporter signature motif; other site 359786002083 Walker B; other site 359786002084 D-loop; other site 359786002085 H-loop/switch region; other site 359786002086 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 359786002087 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 359786002088 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 359786002089 Uncharacterized conserved protein [Function unknown]; Region: COG1284 359786002090 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 359786002091 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 359786002092 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 359786002093 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 359786002094 Walker A/P-loop; other site 359786002095 ATP binding site [chemical binding]; other site 359786002096 Q-loop/lid; other site 359786002097 ABC transporter signature motif; other site 359786002098 Walker B; other site 359786002099 D-loop; other site 359786002100 H-loop/switch region; other site 359786002101 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 359786002102 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786002103 ABC-ATPase subunit interface; other site 359786002104 dimer interface [polypeptide binding]; other site 359786002105 putative PBP binding regions; other site 359786002106 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 359786002107 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786002108 ABC-ATPase subunit interface; other site 359786002109 dimer interface [polypeptide binding]; other site 359786002110 putative PBP binding regions; other site 359786002111 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 359786002112 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 359786002113 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 359786002114 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 359786002115 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 359786002116 Uncharacterized membrane protein [Function unknown]; Region: COG3949 359786002117 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 359786002118 Na binding site [ion binding]; other site 359786002119 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 359786002120 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 359786002121 substrate binding pocket [chemical binding]; other site 359786002122 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 359786002123 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 359786002124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786002125 Coenzyme A binding pocket [chemical binding]; other site 359786002126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 359786002127 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 359786002128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 359786002129 NAD(P) binding site [chemical binding]; other site 359786002130 active site 359786002131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 359786002132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786002133 active site 359786002134 phosphorylation site [posttranslational modification] 359786002135 intermolecular recognition site; other site 359786002136 dimerization interface [polypeptide binding]; other site 359786002137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 359786002138 DNA binding site [nucleotide binding] 359786002139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 359786002140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 359786002141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786002142 ATP binding site [chemical binding]; other site 359786002143 Mg2+ binding site [ion binding]; other site 359786002144 G-X-G motif; other site 359786002145 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 359786002146 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 359786002147 Walker A/P-loop; other site 359786002148 ATP binding site [chemical binding]; other site 359786002149 Q-loop/lid; other site 359786002150 ABC transporter signature motif; other site 359786002151 Walker B; other site 359786002152 D-loop; other site 359786002153 H-loop/switch region; other site 359786002154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 359786002155 Transposase; Region: DDE_Tnp_ISL3; pfam01610 359786002156 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 359786002157 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 359786002158 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 359786002159 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 359786002160 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 359786002161 Surface antigen [General function prediction only]; Region: COG3942 359786002162 CHAP domain; Region: CHAP; pfam05257 359786002163 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 359786002164 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 359786002165 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 359786002166 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786002167 hypothetical protein; Provisional; Region: PRK12378 359786002168 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 359786002169 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 359786002170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 359786002171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 359786002172 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 359786002173 dimerization interface [polypeptide binding]; other site 359786002174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786002175 sugar efflux transporter; Region: 2A0120; TIGR00899 359786002176 putative substrate translocation pore; other site 359786002177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 359786002178 Serine incorporator (Serinc); Region: Serinc; pfam03348 359786002179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786002180 Coenzyme A binding pocket [chemical binding]; other site 359786002181 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 359786002182 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 359786002183 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 359786002184 hypothetical protein; Validated; Region: PRK00124 359786002185 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 359786002186 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 359786002187 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 359786002188 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 359786002189 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 359786002190 Walker A/P-loop; other site 359786002191 ATP binding site [chemical binding]; other site 359786002192 Q-loop/lid; other site 359786002193 ABC transporter signature motif; other site 359786002194 Walker B; other site 359786002195 D-loop; other site 359786002196 H-loop/switch region; other site 359786002197 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 359786002198 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 359786002199 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 359786002200 Walker A/P-loop; other site 359786002201 ATP binding site [chemical binding]; other site 359786002202 Q-loop/lid; other site 359786002203 ABC transporter signature motif; other site 359786002204 Walker B; other site 359786002205 D-loop; other site 359786002206 H-loop/switch region; other site 359786002207 Transcriptional regulators [Transcription]; Region: MarR; COG1846 359786002208 MarR family; Region: MarR; pfam01047 359786002209 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 359786002210 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 359786002211 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 359786002212 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 359786002213 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 359786002214 active site 359786002215 catalytic tetrad [active] 359786002216 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 359786002217 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 359786002218 transmembrane helices; other site 359786002219 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 359786002220 DNA photolyase; Region: DNA_photolyase; pfam00875 359786002221 Predicted membrane protein [Function unknown]; Region: COG4330 359786002222 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 359786002223 trimer interface [polypeptide binding]; other site 359786002224 putative Zn binding site [ion binding]; other site 359786002225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786002226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 359786002227 putative substrate translocation pore; other site 359786002228 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 359786002229 putative deacylase active site [active] 359786002230 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 359786002231 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 359786002232 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 359786002233 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 359786002234 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 359786002235 putative substrate binding site [chemical binding]; other site 359786002236 putative ATP binding site [chemical binding]; other site 359786002237 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 359786002238 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 359786002239 active site 359786002240 phosphorylation site [posttranslational modification] 359786002241 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 359786002242 active site 359786002243 P-loop; other site 359786002244 phosphorylation site [posttranslational modification] 359786002245 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 359786002246 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 359786002247 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 359786002248 active site 359786002249 dimer interface [polypeptide binding]; other site 359786002250 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 359786002251 Domain of unknown function DUF21; Region: DUF21; pfam01595 359786002252 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 359786002253 Transporter associated domain; Region: CorC_HlyC; pfam03471 359786002254 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 359786002255 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 359786002256 active site 359786002257 catalytic tetrad [active] 359786002258 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 359786002259 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 359786002260 Ligand binding site; other site 359786002261 Putative Catalytic site; other site 359786002262 DXD motif; other site 359786002263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 359786002264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 359786002265 dimer interface [polypeptide binding]; other site 359786002266 phosphorylation site [posttranslational modification] 359786002267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786002268 ATP binding site [chemical binding]; other site 359786002269 Mg2+ binding site [ion binding]; other site 359786002270 G-X-G motif; other site 359786002271 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 359786002272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786002273 active site 359786002274 phosphorylation site [posttranslational modification] 359786002275 intermolecular recognition site; other site 359786002276 dimerization interface [polypeptide binding]; other site 359786002277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 359786002278 DNA binding site [nucleotide binding] 359786002279 DoxX; Region: DoxX; pfam07681 359786002280 Electron transfer DM13; Region: DM13; pfam10517 359786002281 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 359786002282 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 359786002283 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 359786002284 active site 359786002285 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 359786002286 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 359786002287 Ligand Binding Site [chemical binding]; other site 359786002288 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 359786002289 Glutamine amidotransferase class-I; Region: GATase; pfam00117 359786002290 glutamine binding [chemical binding]; other site 359786002291 catalytic triad [active] 359786002292 aminodeoxychorismate synthase; Provisional; Region: PRK07508 359786002293 chorismate binding enzyme; Region: Chorismate_bind; cl10555 359786002294 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 359786002295 substrate-cofactor binding pocket; other site 359786002296 Aminotransferase class IV; Region: Aminotran_4; pfam01063 359786002297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786002298 catalytic residue [active] 359786002299 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 359786002300 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 359786002301 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 359786002302 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 359786002303 Sulfatase; Region: Sulfatase; pfam00884 359786002304 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 359786002305 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 359786002306 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 359786002307 ABC transporter; Region: ABC_tran_2; pfam12848 359786002308 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 359786002309 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 359786002310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 359786002311 ATP binding site [chemical binding]; other site 359786002312 putative Mg++ binding site [ion binding]; other site 359786002313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 359786002314 nucleotide binding region [chemical binding]; other site 359786002315 ATP-binding site [chemical binding]; other site 359786002316 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 359786002317 HRDC domain; Region: HRDC; pfam00570 359786002318 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 359786002319 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 359786002320 Walker A/P-loop; other site 359786002321 ATP binding site [chemical binding]; other site 359786002322 Q-loop/lid; other site 359786002323 ABC transporter signature motif; other site 359786002324 Walker B; other site 359786002325 D-loop; other site 359786002326 H-loop/switch region; other site 359786002327 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 359786002328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786002329 dimer interface [polypeptide binding]; other site 359786002330 conserved gate region; other site 359786002331 ABC-ATPase subunit interface; other site 359786002332 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 359786002333 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 359786002334 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 359786002335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 359786002336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786002337 homodimer interface [polypeptide binding]; other site 359786002338 catalytic residue [active] 359786002339 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 359786002340 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 359786002341 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 359786002342 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 359786002343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786002344 putative substrate translocation pore; other site 359786002345 POT family; Region: PTR2; cl17359 359786002346 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 359786002347 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 359786002348 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 359786002349 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 359786002350 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 359786002351 Class I ribonucleotide reductase; Region: RNR_I; cd01679 359786002352 active site 359786002353 dimer interface [polypeptide binding]; other site 359786002354 catalytic residues [active] 359786002355 effector binding site; other site 359786002356 R2 peptide binding site; other site 359786002357 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 359786002358 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 359786002359 dimer interface [polypeptide binding]; other site 359786002360 putative radical transfer pathway; other site 359786002361 diiron center [ion binding]; other site 359786002362 tyrosyl radical; other site 359786002363 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786002364 ABC-ATPase subunit interface; other site 359786002365 dimer interface [polypeptide binding]; other site 359786002366 putative PBP binding regions; other site 359786002367 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786002368 ABC-ATPase subunit interface; other site 359786002369 dimer interface [polypeptide binding]; other site 359786002370 putative PBP binding regions; other site 359786002371 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 359786002372 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 359786002373 Walker A/P-loop; other site 359786002374 ATP binding site [chemical binding]; other site 359786002375 Q-loop/lid; other site 359786002376 ABC transporter signature motif; other site 359786002377 Walker B; other site 359786002378 D-loop; other site 359786002379 H-loop/switch region; other site 359786002380 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 359786002381 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 359786002382 putative ligand binding residues [chemical binding]; other site 359786002383 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 359786002384 CHY zinc finger; Region: zf-CHY; pfam05495 359786002385 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 359786002386 FAD binding domain; Region: FAD_binding_4; pfam01565 359786002387 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 359786002388 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 359786002389 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 359786002390 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 359786002391 peptidase T; Region: peptidase-T; TIGR01882 359786002392 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 359786002393 metal binding site [ion binding]; metal-binding site 359786002394 dimer interface [polypeptide binding]; other site 359786002395 Uncharacterized conserved protein [Function unknown]; Region: COG3610 359786002396 Uncharacterized conserved protein [Function unknown]; Region: COG2966 359786002397 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 359786002398 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 359786002399 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 359786002400 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 359786002401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 359786002402 metal binding site [ion binding]; metal-binding site 359786002403 active site 359786002404 I-site; other site 359786002405 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 359786002406 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 359786002407 Mg++ binding site [ion binding]; other site 359786002408 putative catalytic motif [active] 359786002409 substrate binding site [chemical binding]; other site 359786002410 Uncharacterized conserved protein [Function unknown]; Region: COG1739 359786002411 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 359786002412 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 359786002413 EDD domain protein, DegV family; Region: DegV; TIGR00762 359786002414 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 359786002415 DEAD-like helicases superfamily; Region: DEXDc; smart00487 359786002416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 359786002417 ATP binding site [chemical binding]; other site 359786002418 putative Mg++ binding site [ion binding]; other site 359786002419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 359786002420 nucleotide binding region [chemical binding]; other site 359786002421 ATP-binding site [chemical binding]; other site 359786002422 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 359786002423 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 359786002424 active site 359786002425 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 359786002426 30S subunit binding site; other site 359786002427 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 359786002428 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 359786002429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 359786002430 nucleotide binding region [chemical binding]; other site 359786002431 ATP-binding site [chemical binding]; other site 359786002432 SEC-C motif; Region: SEC-C; pfam02810 359786002433 peptide chain release factor 2; Provisional; Region: PRK06746 359786002434 This domain is found in peptide chain release factors; Region: PCRF; smart00937 359786002435 RF-1 domain; Region: RF-1; pfam00472 359786002436 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 359786002437 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 359786002438 Surface antigen [General function prediction only]; Region: COG3942 359786002439 CHAP domain; Region: CHAP; pfam05257 359786002440 HD domain; Region: HD_3; cl17350 359786002441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 359786002442 excinuclease ABC subunit B; Provisional; Region: PRK05298 359786002443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 359786002444 ATP binding site [chemical binding]; other site 359786002445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 359786002446 nucleotide binding region [chemical binding]; other site 359786002447 ATP-binding site [chemical binding]; other site 359786002448 Ultra-violet resistance protein B; Region: UvrB; pfam12344 359786002449 UvrB/uvrC motif; Region: UVR; pfam02151 359786002450 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 359786002451 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 359786002452 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 359786002453 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 359786002454 HPr kinase/phosphorylase; Provisional; Region: PRK05428 359786002455 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 359786002456 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 359786002457 Hpr binding site; other site 359786002458 active site 359786002459 homohexamer subunit interaction site [polypeptide binding]; other site 359786002460 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 359786002461 putative acyl transferase; Provisional; Region: PRK10191 359786002462 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 359786002463 trimer interface [polypeptide binding]; other site 359786002464 active site 359786002465 substrate binding site [chemical binding]; other site 359786002466 CoA binding site [chemical binding]; other site 359786002467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 359786002468 binding surface 359786002469 TPR motif; other site 359786002470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 359786002471 TPR motif; other site 359786002472 binding surface 359786002473 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 359786002474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 359786002475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786002476 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 359786002477 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 359786002478 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 359786002479 phosphate binding site [ion binding]; other site 359786002480 dimer interface [polypeptide binding]; other site 359786002481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 359786002482 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 359786002483 Clp protease; Region: CLP_protease; pfam00574 359786002484 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 359786002485 oligomer interface [polypeptide binding]; other site 359786002486 active site residues [active] 359786002487 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 359786002488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 359786002489 NAD(P) binding site [chemical binding]; other site 359786002490 active site 359786002491 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 359786002492 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 359786002493 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 359786002494 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 359786002495 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 359786002496 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 359786002497 Phosphoglycerate kinase; Region: PGK; pfam00162 359786002498 substrate binding site [chemical binding]; other site 359786002499 hinge regions; other site 359786002500 ADP binding site [chemical binding]; other site 359786002501 catalytic site [active] 359786002502 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 359786002503 triosephosphate isomerase; Provisional; Region: PRK14565 359786002504 substrate binding site [chemical binding]; other site 359786002505 dimer interface [polypeptide binding]; other site 359786002506 catalytic triad [active] 359786002507 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 359786002508 phosphoglyceromutase; Provisional; Region: PRK05434 359786002509 enolase; Provisional; Region: eno; PRK00077 359786002510 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 359786002511 dimer interface [polypeptide binding]; other site 359786002512 metal binding site [ion binding]; metal-binding site 359786002513 substrate binding pocket [chemical binding]; other site 359786002514 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 359786002515 Esterase/lipase [General function prediction only]; Region: COG1647 359786002516 ribonuclease R; Region: RNase_R; TIGR02063 359786002517 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 359786002518 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 359786002519 RNB domain; Region: RNB; pfam00773 359786002520 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 359786002521 RNA binding site [nucleotide binding]; other site 359786002522 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 359786002523 SmpB-tmRNA interface; other site 359786002524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786002525 Coenzyme A binding pocket [chemical binding]; other site 359786002526 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786002527 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 359786002528 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 359786002529 Staphylococcal nuclease homologues; Region: SNc; smart00318 359786002530 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 359786002531 Catalytic site; other site 359786002532 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 359786002533 DNA-binding site [nucleotide binding]; DNA binding site 359786002534 RNA-binding motif; other site 359786002535 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 359786002536 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 359786002537 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 359786002538 catalytic core [active] 359786002539 Lysine efflux permease [General function prediction only]; Region: COG1279 359786002540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 359786002541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 359786002542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 359786002543 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 359786002544 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 359786002545 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 359786002546 active site 359786002547 catalytic residue [active] 359786002548 dimer interface [polypeptide binding]; other site 359786002549 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 359786002550 putative FMN binding site [chemical binding]; other site 359786002551 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 359786002552 catalytic residues [active] 359786002553 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 359786002554 ArsC family; Region: ArsC; pfam03960 359786002555 putative ArsC-like catalytic residues; other site 359786002556 putative TRX-like catalytic residues [active] 359786002557 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 359786002558 lipoyl attachment site [posttranslational modification]; other site 359786002559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 359786002560 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 359786002561 putative active site [active] 359786002562 putative metal binding site [ion binding]; other site 359786002563 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 359786002564 catalytic residues [active] 359786002565 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 359786002566 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 359786002567 Walker A/P-loop; other site 359786002568 ATP binding site [chemical binding]; other site 359786002569 Q-loop/lid; other site 359786002570 ABC transporter signature motif; other site 359786002571 Walker B; other site 359786002572 D-loop; other site 359786002573 H-loop/switch region; other site 359786002574 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 359786002575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786002576 dimer interface [polypeptide binding]; other site 359786002577 conserved gate region; other site 359786002578 ABC-ATPase subunit interface; other site 359786002579 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 359786002580 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 359786002581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 359786002582 Predicted membrane protein [Function unknown]; Region: COG2035 359786002583 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 359786002584 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 359786002585 Walker A/P-loop; other site 359786002586 ATP binding site [chemical binding]; other site 359786002587 Q-loop/lid; other site 359786002588 ABC transporter signature motif; other site 359786002589 Walker B; other site 359786002590 D-loop; other site 359786002591 H-loop/switch region; other site 359786002592 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 359786002593 FeS assembly protein SufD; Region: sufD; TIGR01981 359786002594 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 359786002595 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 359786002596 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 359786002597 catalytic residue [active] 359786002598 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 359786002599 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 359786002600 trimerization site [polypeptide binding]; other site 359786002601 active site 359786002602 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 359786002603 FeS assembly protein SufB; Region: sufB; TIGR01980 359786002604 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 359786002605 active site 359786002606 DNA binding site [nucleotide binding] 359786002607 Int/Topo IB signature motif; other site 359786002608 Short C-terminal domain; Region: SHOCT; pfam09851 359786002609 Domain of unknown function (DUF955); Region: DUF955; pfam06114 359786002610 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 359786002611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786002612 non-specific DNA binding site [nucleotide binding]; other site 359786002613 salt bridge; other site 359786002614 sequence-specific DNA binding site [nucleotide binding]; other site 359786002615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786002616 non-specific DNA binding site [nucleotide binding]; other site 359786002617 salt bridge; other site 359786002618 sequence-specific DNA binding site [nucleotide binding]; other site 359786002619 BRO family, N-terminal domain; Region: Bro-N; smart01040 359786002620 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 359786002621 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 359786002622 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 359786002623 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 359786002624 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 359786002625 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 359786002626 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 359786002627 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 359786002628 dimer interface [polypeptide binding]; other site 359786002629 ssDNA binding site [nucleotide binding]; other site 359786002630 tetramer (dimer of dimers) interface [polypeptide binding]; other site 359786002631 Protein of unknown function (DUF968); Region: DUF968; pfam06147 359786002632 Helix-turn-helix domain; Region: HTH_36; pfam13730 359786002633 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 359786002634 hypothetical protein; Validated; Region: PRK08116 359786002635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786002636 Walker A motif; other site 359786002637 ATP binding site [chemical binding]; other site 359786002638 Walker B motif; other site 359786002639 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 359786002640 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 359786002641 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 359786002642 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 359786002643 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 359786002644 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 359786002645 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 359786002646 trimer interface [polypeptide binding]; other site 359786002647 active site 359786002648 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 359786002649 Transcriptional activator RinB; Region: RinB; pfam06116 359786002650 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 359786002651 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 359786002652 Terminase small subunit; Region: Terminase_2; pfam03592 359786002653 Phage terminase large subunit; Region: Terminase_3; cl12054 359786002654 Terminase-like family; Region: Terminase_6; pfam03237 359786002655 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 359786002656 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 359786002657 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 359786002658 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 359786002659 Phage capsid family; Region: Phage_capsid; pfam05065 359786002660 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 359786002661 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 359786002662 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 359786002663 Phage protein; Region: DUF3647; pfam12363 359786002664 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 359786002665 Phage-related protein [Function unknown]; Region: COG5412 359786002666 membrane protein P6; Region: PHA01399 359786002667 Phage tail protein; Region: Sipho_tail; pfam05709 359786002668 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 359786002669 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 359786002670 active site 359786002671 catalytic triad [active] 359786002672 oxyanion hole [active] 359786002673 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 359786002674 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 359786002675 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 359786002676 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 359786002677 CHAP domain; Region: CHAP; pfam05257 359786002678 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 359786002679 Lysozyme subfamily 2; Region: LYZ2; smart00047 359786002680 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 359786002681 Phage tail repeat like; Region: PTR; pfam12789 359786002682 holin, SPP1 family; Region: holin_SPP1; TIGR01592 359786002683 CHAP domain; Region: CHAP; pfam05257 359786002684 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 359786002685 active site 359786002686 metal binding site [ion binding]; metal-binding site 359786002687 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 359786002688 Domain of unknown function DUF21; Region: DUF21; pfam01595 359786002689 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 359786002690 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 359786002691 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 359786002692 FMN binding site [chemical binding]; other site 359786002693 substrate binding site [chemical binding]; other site 359786002694 putative catalytic residue [active] 359786002695 Uncharacterized conserved protein [Function unknown]; Region: COG1801 359786002696 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 359786002697 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 359786002698 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 359786002699 active site 359786002700 metal binding site [ion binding]; metal-binding site 359786002701 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 359786002702 lipoyl synthase; Provisional; Region: PRK05481 359786002703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 359786002704 FeS/SAM binding site; other site 359786002705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 359786002706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 359786002707 Transposase; Region: DDE_Tnp_ISL3; pfam01610 359786002708 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 359786002709 Uncharacterized conserved protein [Function unknown]; Region: COG2445 359786002710 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 359786002711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786002712 active site 359786002713 motif I; other site 359786002714 motif II; other site 359786002715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786002716 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 359786002717 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 359786002718 dimerization interface [polypeptide binding]; other site 359786002719 ligand binding site [chemical binding]; other site 359786002720 NADP binding site [chemical binding]; other site 359786002721 catalytic site [active] 359786002722 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 359786002723 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 359786002724 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 359786002725 acyl-activating enzyme (AAE) consensus motif; other site 359786002726 AMP binding site [chemical binding]; other site 359786002727 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 359786002728 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 359786002729 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 359786002730 DltD N-terminal region; Region: DltD_N; pfam04915 359786002731 DltD central region; Region: DltD_M; pfam04918 359786002732 DltD C-terminal region; Region: DltD_C; pfam04914 359786002733 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 359786002734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 359786002735 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 359786002736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786002737 hypothetical protein; Provisional; Region: PRK13669 359786002738 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 359786002739 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 359786002740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786002741 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 359786002742 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 359786002743 interface (dimer of trimers) [polypeptide binding]; other site 359786002744 Substrate-binding/catalytic site; other site 359786002745 Zn-binding sites [ion binding]; other site 359786002746 Predicted permease [General function prediction only]; Region: COG2056 359786002747 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 359786002748 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 359786002749 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 359786002750 CoenzymeA binding site [chemical binding]; other site 359786002751 subunit interaction site [polypeptide binding]; other site 359786002752 PHB binding site; other site 359786002753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 359786002754 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 359786002755 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 359786002756 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 359786002757 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 359786002758 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 359786002759 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 359786002760 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 359786002761 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 359786002762 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 359786002763 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 359786002764 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 359786002765 Kinase associated protein B; Region: KapB; pfam08810 359786002766 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 359786002767 active site 359786002768 general stress protein 13; Validated; Region: PRK08059 359786002769 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 359786002770 RNA binding site [nucleotide binding]; other site 359786002771 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 359786002772 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 359786002773 putative active site [active] 359786002774 putative FMN binding site [chemical binding]; other site 359786002775 putative substrate binding site [chemical binding]; other site 359786002776 putative catalytic residue [active] 359786002777 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 359786002778 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 359786002779 inhibitor-cofactor binding pocket; inhibition site 359786002780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786002781 catalytic residue [active] 359786002782 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 359786002783 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 359786002784 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 359786002785 NAD(P) binding site [chemical binding]; other site 359786002786 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 359786002787 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 359786002788 active site 359786002789 catalytic site [active] 359786002790 metal binding site [ion binding]; metal-binding site 359786002791 argininosuccinate lyase; Provisional; Region: PRK00855 359786002792 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 359786002793 active sites [active] 359786002794 tetramer interface [polypeptide binding]; other site 359786002795 argininosuccinate synthase; Provisional; Region: PRK13820 359786002796 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 359786002797 ANP binding site [chemical binding]; other site 359786002798 Substrate Binding Site II [chemical binding]; other site 359786002799 Substrate Binding Site I [chemical binding]; other site 359786002800 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 359786002801 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 359786002802 active site 359786002803 dimer interface [polypeptide binding]; other site 359786002804 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 359786002805 dimer interface [polypeptide binding]; other site 359786002806 active site 359786002807 Uncharacterized conserved protein [Function unknown]; Region: COG0398 359786002808 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 359786002809 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 359786002810 Catalytic site [active] 359786002811 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 359786002812 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 359786002813 Catalytic site [active] 359786002814 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 359786002815 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 359786002816 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 359786002817 Part of AAA domain; Region: AAA_19; pfam13245 359786002818 Family description; Region: UvrD_C_2; pfam13538 359786002819 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 359786002820 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 359786002821 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 359786002822 hypothetical protein; Provisional; Region: PRK13673 359786002823 coenzyme A disulfide reductase; Provisional; Region: PRK13512 359786002824 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 359786002825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786002826 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 359786002827 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 359786002828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786002829 active site 359786002830 motif I; other site 359786002831 motif II; other site 359786002832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786002833 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 359786002834 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 359786002835 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 359786002836 catalytic triad [active] 359786002837 catalytic triad [active] 359786002838 oxyanion hole [active] 359786002839 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 359786002840 Clp amino terminal domain; Region: Clp_N; pfam02861 359786002841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786002842 Walker A motif; other site 359786002843 ATP binding site [chemical binding]; other site 359786002844 Walker B motif; other site 359786002845 arginine finger; other site 359786002846 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 359786002847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786002848 Walker A motif; other site 359786002849 ATP binding site [chemical binding]; other site 359786002850 Walker B motif; other site 359786002851 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 359786002852 Transcriptional regulator [Transcription]; Region: LysR; COG0583 359786002853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 359786002854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 359786002855 dimerization interface [polypeptide binding]; other site 359786002856 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 359786002857 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 359786002858 active site 359786002859 catalytic residues [active] 359786002860 metal binding site [ion binding]; metal-binding site 359786002861 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 359786002862 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 359786002863 substrate binding site [chemical binding]; other site 359786002864 MAP domain; Region: MAP; pfam03642 359786002865 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 359786002866 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 359786002867 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 359786002868 dimer interface [polypeptide binding]; other site 359786002869 active site 359786002870 CoA binding pocket [chemical binding]; other site 359786002871 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 359786002872 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 359786002873 dimer interface [polypeptide binding]; other site 359786002874 active site 359786002875 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 359786002876 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 359786002877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786002878 dimer interface [polypeptide binding]; other site 359786002879 conserved gate region; other site 359786002880 putative PBP binding loops; other site 359786002881 ABC-ATPase subunit interface; other site 359786002882 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 359786002883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786002884 dimer interface [polypeptide binding]; other site 359786002885 conserved gate region; other site 359786002886 putative PBP binding loops; other site 359786002887 ABC-ATPase subunit interface; other site 359786002888 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 359786002889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 359786002890 Walker A/P-loop; other site 359786002891 ATP binding site [chemical binding]; other site 359786002892 Q-loop/lid; other site 359786002893 ABC transporter signature motif; other site 359786002894 Walker B; other site 359786002895 D-loop; other site 359786002896 H-loop/switch region; other site 359786002897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 359786002898 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 359786002899 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 359786002900 Walker A/P-loop; other site 359786002901 ATP binding site [chemical binding]; other site 359786002902 Q-loop/lid; other site 359786002903 ABC transporter signature motif; other site 359786002904 Walker B; other site 359786002905 D-loop; other site 359786002906 H-loop/switch region; other site 359786002907 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 359786002908 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 359786002909 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 359786002910 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 359786002911 peptide binding site [polypeptide binding]; other site 359786002912 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 359786002913 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 359786002914 peptide binding site [polypeptide binding]; other site 359786002915 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 359786002916 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 359786002917 Walker A/P-loop; other site 359786002918 ATP binding site [chemical binding]; other site 359786002919 Q-loop/lid; other site 359786002920 ABC transporter signature motif; other site 359786002921 Walker B; other site 359786002922 D-loop; other site 359786002923 H-loop/switch region; other site 359786002924 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 359786002925 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 359786002926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 359786002927 Walker A/P-loop; other site 359786002928 ATP binding site [chemical binding]; other site 359786002929 Q-loop/lid; other site 359786002930 ABC transporter signature motif; other site 359786002931 Walker B; other site 359786002932 D-loop; other site 359786002933 H-loop/switch region; other site 359786002934 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 359786002935 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 359786002936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786002937 dimer interface [polypeptide binding]; other site 359786002938 conserved gate region; other site 359786002939 putative PBP binding loops; other site 359786002940 ABC-ATPase subunit interface; other site 359786002941 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 359786002942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786002943 dimer interface [polypeptide binding]; other site 359786002944 conserved gate region; other site 359786002945 putative PBP binding loops; other site 359786002946 ABC-ATPase subunit interface; other site 359786002947 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 359786002948 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 359786002949 active site 359786002950 HIGH motif; other site 359786002951 dimer interface [polypeptide binding]; other site 359786002952 KMSKS motif; other site 359786002953 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 359786002954 ArsC family; Region: ArsC; pfam03960 359786002955 putative catalytic residues [active] 359786002956 thiol/disulfide switch; other site 359786002957 adaptor protein; Provisional; Region: PRK02315 359786002958 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 359786002959 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 359786002960 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 359786002961 active site 359786002962 Zn binding site [ion binding]; other site 359786002963 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 359786002964 Thioredoxin; Region: Thioredoxin_5; pfam13743 359786002965 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 359786002966 apolar tunnel; other site 359786002967 heme binding site [chemical binding]; other site 359786002968 dimerization interface [polypeptide binding]; other site 359786002969 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 359786002970 putative active site [active] 359786002971 putative metal binding residues [ion binding]; other site 359786002972 signature motif; other site 359786002973 putative triphosphate binding site [ion binding]; other site 359786002974 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 359786002975 synthetase active site [active] 359786002976 NTP binding site [chemical binding]; other site 359786002977 metal binding site [ion binding]; metal-binding site 359786002978 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 359786002979 ATP-NAD kinase; Region: NAD_kinase; pfam01513 359786002980 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 359786002981 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 359786002982 active site 359786002983 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 359786002984 MgtE intracellular N domain; Region: MgtE_N; smart00924 359786002985 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 359786002986 Divalent cation transporter; Region: MgtE; pfam01769 359786002987 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 359786002988 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 359786002989 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 359786002990 TrkA-N domain; Region: TrkA_N; pfam02254 359786002991 TrkA-C domain; Region: TrkA_C; pfam02080 359786002992 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 359786002993 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 359786002994 NAD binding site [chemical binding]; other site 359786002995 homotetramer interface [polypeptide binding]; other site 359786002996 homodimer interface [polypeptide binding]; other site 359786002997 substrate binding site [chemical binding]; other site 359786002998 active site 359786002999 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 359786003000 Domain of unknown function DUF20; Region: UPF0118; pfam01594 359786003001 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 359786003002 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 359786003003 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 359786003004 Putative esterase; Region: Esterase; pfam00756 359786003005 hypothetical protein; Provisional; Region: PRK13679 359786003006 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 359786003007 Major Facilitator Superfamily; Region: MFS_1; pfam07690 359786003008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786003009 putative substrate translocation pore; other site 359786003010 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 359786003011 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 359786003012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 359786003013 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 359786003014 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 359786003015 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 359786003016 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 359786003017 YueH-like protein; Region: YueH; pfam14166 359786003018 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 359786003019 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 359786003020 G1 box; other site 359786003021 putative GEF interaction site [polypeptide binding]; other site 359786003022 GTP/Mg2+ binding site [chemical binding]; other site 359786003023 Switch I region; other site 359786003024 G2 box; other site 359786003025 G3 box; other site 359786003026 Switch II region; other site 359786003027 G4 box; other site 359786003028 G5 box; other site 359786003029 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 359786003030 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 359786003031 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 359786003032 Int/Topo IB signature motif; other site 359786003033 Domain of unknown function (DUF955); Region: DUF955; pfam06114 359786003034 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 359786003035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786003036 non-specific DNA binding site [nucleotide binding]; other site 359786003037 salt bridge; other site 359786003038 sequence-specific DNA binding site [nucleotide binding]; other site 359786003039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 359786003040 non-specific DNA binding site [nucleotide binding]; other site 359786003041 salt bridge; other site 359786003042 sequence-specific DNA binding site [nucleotide binding]; other site 359786003043 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 359786003044 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 359786003045 Homeodomain-like domain; Region: HTH_23; pfam13384 359786003046 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 359786003047 Predicted transcriptional regulator [Transcription]; Region: COG5340 359786003048 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 359786003049 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 359786003050 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 359786003051 active site 359786003052 DNA binding site [nucleotide binding] 359786003053 catalytic site [active] 359786003054 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 359786003055 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 359786003056 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 359786003057 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 359786003058 YopX protein; Region: YopX; pfam09643 359786003059 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 359786003060 dUTPase; Region: dUTPase_2; pfam08761 359786003061 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 359786003062 active site 359786003063 homodimer interface [polypeptide binding]; other site 359786003064 metal binding site [ion binding]; metal-binding site 359786003065 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 359786003066 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 359786003067 Transcriptional activator RinB; Region: RinB; pfam06116 359786003068 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 359786003069 Virulence-associated protein E; Region: VirE; pfam05272 359786003070 VRR-NUC domain; Region: VRR_NUC; pfam08774 359786003071 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 359786003072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 359786003073 ATP binding site [chemical binding]; other site 359786003074 putative Mg++ binding site [ion binding]; other site 359786003075 helicase superfamily c-terminal domain; Region: HELICc; smart00490 359786003076 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 359786003077 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 359786003078 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 359786003079 active site 359786003080 Phage terminase, small subunit; Region: Terminase_4; pfam05119 359786003081 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 359786003082 Phage-related protein [Function unknown]; Region: COG4695; cl01923 359786003083 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 359786003084 Clp protease; Region: CLP_protease; pfam00574 359786003085 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 359786003086 oligomer interface [polypeptide binding]; other site 359786003087 active site residues [active] 359786003088 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 359786003089 Phage capsid family; Region: Phage_capsid; pfam05065 359786003090 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 359786003091 oligomerization interface [polypeptide binding]; other site 359786003092 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 359786003093 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 359786003094 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 359786003095 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 359786003096 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 359786003097 linker region; other site 359786003098 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 359786003099 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 359786003100 dimer interface [polypeptide binding]; other site 359786003101 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 359786003102 Peptidase family M23; Region: Peptidase_M23; pfam01551 359786003103 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 359786003104 N-acetyl-D-glucosamine binding site [chemical binding]; other site 359786003105 catalytic residue [active] 359786003106 Phage tail protein; Region: Sipho_tail; pfam05709 359786003107 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 359786003108 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 359786003109 hypothetical protein; Provisional; Region: PRK05926 359786003110 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 359786003111 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 359786003112 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 359786003113 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 359786003114 Bacteriophage holin; Region: Phage_holin_1; pfam04531 359786003115 CHAP domain; Region: CHAP; pfam05257 359786003116 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 359786003117 amidase catalytic site [active] 359786003118 Zn binding residues [ion binding]; other site 359786003119 substrate binding site [chemical binding]; other site 359786003120 Bacterial SH3 domain; Region: SH3_5; pfam08460 359786003121 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 359786003122 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 359786003123 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 359786003124 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 359786003125 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 359786003126 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 359786003127 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 359786003128 active site 359786003129 metal binding site [ion binding]; metal-binding site 359786003130 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 359786003131 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 359786003132 IDEAL domain; Region: IDEAL; pfam08858 359786003133 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 359786003134 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 359786003135 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 359786003136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 359786003137 CAAX protease self-immunity; Region: Abi; cl00558 359786003138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 359786003139 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 359786003140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 359786003141 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 359786003142 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 359786003143 Walker A/P-loop; other site 359786003144 ATP binding site [chemical binding]; other site 359786003145 Q-loop/lid; other site 359786003146 ABC transporter signature motif; other site 359786003147 Walker B; other site 359786003148 D-loop; other site 359786003149 H-loop/switch region; other site 359786003150 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 359786003151 Predicted membrane protein [Function unknown]; Region: COG2259 359786003152 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 359786003153 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 359786003154 siderophore binding site; other site 359786003155 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 359786003156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786003157 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 359786003158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 359786003159 Coenzyme A binding pocket [chemical binding]; other site 359786003160 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 359786003161 UbiA prenyltransferase family; Region: UbiA; pfam01040 359786003162 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 359786003163 isochorismate synthases; Region: isochor_syn; TIGR00543 359786003164 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 359786003165 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 359786003166 dimer interface [polypeptide binding]; other site 359786003167 tetramer interface [polypeptide binding]; other site 359786003168 PYR/PP interface [polypeptide binding]; other site 359786003169 TPP binding site [chemical binding]; other site 359786003170 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 359786003171 TPP-binding site; other site 359786003172 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 359786003173 PGAP1-like protein; Region: PGAP1; pfam07819 359786003174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 359786003175 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 359786003176 substrate binding site [chemical binding]; other site 359786003177 oxyanion hole (OAH) forming residues; other site 359786003178 trimer interface [polypeptide binding]; other site 359786003179 Staphostatin B; Region: Staphostatin_B; pfam09023 359786003180 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 359786003181 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 359786003182 aminotransferase A; Validated; Region: PRK07683 359786003183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 359786003184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786003185 homodimer interface [polypeptide binding]; other site 359786003186 catalytic residue [active] 359786003187 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 359786003188 Acyltransferase family; Region: Acyl_transf_3; pfam01757 359786003189 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 359786003190 MarR family; Region: MarR; pfam01047 359786003191 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 359786003192 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 359786003193 amidase catalytic site [active] 359786003194 Zn binding residues [ion binding]; other site 359786003195 substrate binding site [chemical binding]; other site 359786003196 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 359786003197 Lysozyme subfamily 2; Region: LYZ2; smart00047 359786003198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786003199 Coenzyme A binding pocket [chemical binding]; other site 359786003200 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 359786003201 Transcriptional regulator [Transcription]; Region: LytR; COG1316 359786003202 Beta-lactamase; Region: Beta-lactamase; pfam00144 359786003203 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 359786003204 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 359786003205 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 359786003206 Subunit I/III interface [polypeptide binding]; other site 359786003207 Subunit III/IV interface [polypeptide binding]; other site 359786003208 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 359786003209 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 359786003210 D-pathway; other site 359786003211 Putative ubiquinol binding site [chemical binding]; other site 359786003212 Low-spin heme (heme b) binding site [chemical binding]; other site 359786003213 Putative water exit pathway; other site 359786003214 Binuclear center (heme o3/CuB) [ion binding]; other site 359786003215 K-pathway; other site 359786003216 Putative proton exit pathway; other site 359786003217 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 359786003218 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 359786003219 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 359786003220 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 359786003221 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 359786003222 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 359786003223 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 359786003224 homodimer interface [polypeptide binding]; other site 359786003225 NADP binding site [chemical binding]; other site 359786003226 substrate binding site [chemical binding]; other site 359786003227 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 359786003228 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 359786003229 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 359786003230 NAD binding site [chemical binding]; other site 359786003231 ATP-grasp domain; Region: ATP-grasp; pfam02222 359786003232 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 359786003233 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 359786003234 ATP binding site [chemical binding]; other site 359786003235 active site 359786003236 substrate binding site [chemical binding]; other site 359786003237 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 359786003238 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 359786003239 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 359786003240 putative active site [active] 359786003241 catalytic triad [active] 359786003242 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 359786003243 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 359786003244 dimerization interface [polypeptide binding]; other site 359786003245 ATP binding site [chemical binding]; other site 359786003246 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 359786003247 dimerization interface [polypeptide binding]; other site 359786003248 ATP binding site [chemical binding]; other site 359786003249 amidophosphoribosyltransferase; Provisional; Region: PRK07272 359786003250 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 359786003251 active site 359786003252 tetramer interface [polypeptide binding]; other site 359786003253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 359786003254 active site 359786003255 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 359786003256 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 359786003257 dimerization interface [polypeptide binding]; other site 359786003258 putative ATP binding site [chemical binding]; other site 359786003259 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 359786003260 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 359786003261 active site 359786003262 substrate binding site [chemical binding]; other site 359786003263 cosubstrate binding site; other site 359786003264 catalytic site [active] 359786003265 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 359786003266 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 359786003267 purine monophosphate binding site [chemical binding]; other site 359786003268 dimer interface [polypeptide binding]; other site 359786003269 putative catalytic residues [active] 359786003270 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 359786003271 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 359786003272 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 359786003273 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 359786003274 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 359786003275 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 359786003276 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 359786003277 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 359786003278 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 359786003279 Walker A/P-loop; other site 359786003280 ATP binding site [chemical binding]; other site 359786003281 Q-loop/lid; other site 359786003282 ABC transporter signature motif; other site 359786003283 Walker B; other site 359786003284 D-loop; other site 359786003285 H-loop/switch region; other site 359786003286 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 359786003287 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 359786003288 Walker A/P-loop; other site 359786003289 ATP binding site [chemical binding]; other site 359786003290 Q-loop/lid; other site 359786003291 ABC transporter signature motif; other site 359786003292 Walker B; other site 359786003293 D-loop; other site 359786003294 H-loop/switch region; other site 359786003295 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 359786003296 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 359786003297 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 359786003298 putative RNA binding site [nucleotide binding]; other site 359786003299 Methyltransferase domain; Region: Methyltransf_26; pfam13659 359786003300 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 359786003301 dimerization domain swap beta strand [polypeptide binding]; other site 359786003302 regulatory protein interface [polypeptide binding]; other site 359786003303 active site 359786003304 regulatory phosphorylation site [posttranslational modification]; other site 359786003305 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 359786003306 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 359786003307 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 359786003308 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 359786003309 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 359786003310 catalytic residues [active] 359786003311 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 359786003312 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 359786003313 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 359786003314 TrkA-N domain; Region: TrkA_N; pfam02254 359786003315 TrkA-C domain; Region: TrkA_C; pfam02080 359786003316 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 359786003317 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 359786003318 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 359786003319 hypothetical protein; Provisional; Region: PRK13667 359786003320 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 359786003321 active site 359786003322 catalytic residues [active] 359786003323 metal binding site [ion binding]; metal-binding site 359786003324 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 359786003325 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 359786003326 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 359786003327 TPP-binding site [chemical binding]; other site 359786003328 tetramer interface [polypeptide binding]; other site 359786003329 heterodimer interface [polypeptide binding]; other site 359786003330 phosphorylation loop region [posttranslational modification] 359786003331 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 359786003332 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 359786003333 alpha subunit interface [polypeptide binding]; other site 359786003334 TPP binding site [chemical binding]; other site 359786003335 heterodimer interface [polypeptide binding]; other site 359786003336 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 359786003337 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 359786003338 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 359786003339 E3 interaction surface; other site 359786003340 lipoyl attachment site [posttranslational modification]; other site 359786003341 e3 binding domain; Region: E3_binding; pfam02817 359786003342 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 359786003343 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 359786003344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 359786003345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786003346 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 359786003347 hypothetical protein; Provisional; Region: PRK04387 359786003348 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 359786003349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786003350 non-specific DNA binding site [nucleotide binding]; other site 359786003351 salt bridge; other site 359786003352 sequence-specific DNA binding site [nucleotide binding]; other site 359786003353 Cupin domain; Region: Cupin_2; pfam07883 359786003354 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 359786003355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786003356 Walker A/P-loop; other site 359786003357 ATP binding site [chemical binding]; other site 359786003358 Q-loop/lid; other site 359786003359 ABC transporter signature motif; other site 359786003360 Walker B; other site 359786003361 D-loop; other site 359786003362 H-loop/switch region; other site 359786003363 TOBE domain; Region: TOBE_2; pfam08402 359786003364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786003365 putative PBP binding loops; other site 359786003366 dimer interface [polypeptide binding]; other site 359786003367 ABC-ATPase subunit interface; other site 359786003368 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 359786003369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786003370 dimer interface [polypeptide binding]; other site 359786003371 conserved gate region; other site 359786003372 putative PBP binding loops; other site 359786003373 ABC-ATPase subunit interface; other site 359786003374 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 359786003375 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 359786003376 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 359786003377 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 359786003378 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 359786003379 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 359786003380 manganese transport protein MntH; Reviewed; Region: PRK00701 359786003381 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 359786003382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 359786003383 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 359786003384 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 359786003385 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 359786003386 active site 359786003387 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 359786003388 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 359786003389 G1 box; other site 359786003390 putative GEF interaction site [polypeptide binding]; other site 359786003391 GTP/Mg2+ binding site [chemical binding]; other site 359786003392 Switch I region; other site 359786003393 G2 box; other site 359786003394 G3 box; other site 359786003395 Switch II region; other site 359786003396 G4 box; other site 359786003397 G5 box; other site 359786003398 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 359786003399 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 359786003400 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 359786003401 hypothetical protein; Provisional; Region: PRK13666 359786003402 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 359786003403 pyruvate carboxylase; Reviewed; Region: PRK12999 359786003404 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 359786003405 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 359786003406 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 359786003407 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 359786003408 active site 359786003409 catalytic residues [active] 359786003410 metal binding site [ion binding]; metal-binding site 359786003411 homodimer binding site [polypeptide binding]; other site 359786003412 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 359786003413 carboxyltransferase (CT) interaction site; other site 359786003414 biotinylation site [posttranslational modification]; other site 359786003415 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 359786003416 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 359786003417 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 359786003418 UbiA prenyltransferase family; Region: UbiA; pfam01040 359786003419 Predicted membrane protein [Function unknown]; Region: COG2322 359786003420 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 359786003421 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 359786003422 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 359786003423 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 359786003424 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 359786003425 putative active site [active] 359786003426 catalytic site [active] 359786003427 putative metal binding site [ion binding]; other site 359786003428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 359786003429 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 359786003430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786003431 S-adenosylmethionine binding site [chemical binding]; other site 359786003432 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 359786003433 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 359786003434 active site 359786003435 (T/H)XGH motif; other site 359786003436 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 359786003437 hypothetical protein; Provisional; Region: PRK13670 359786003438 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 359786003439 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 359786003440 heme uptake protein IsdB; Region: IsdB; TIGR03657 359786003441 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786003442 NEAr Transporter domain; Region: NEAT; smart00725 359786003443 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 359786003444 heme-binding site [chemical binding]; other site 359786003445 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 359786003446 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 359786003447 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 359786003448 heme-binding site [chemical binding]; other site 359786003449 heme uptake protein IsdC; Region: IsdC; TIGR03656 359786003450 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 359786003451 heme-binding site [chemical binding]; other site 359786003452 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 359786003453 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 359786003454 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 359786003455 intersubunit interface [polypeptide binding]; other site 359786003456 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 359786003457 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786003458 ABC-ATPase subunit interface; other site 359786003459 dimer interface [polypeptide binding]; other site 359786003460 putative PBP binding regions; other site 359786003461 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 359786003462 active site 359786003463 catalytic site [active] 359786003464 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 359786003465 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 359786003466 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 359786003467 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 359786003468 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 359786003469 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 359786003470 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 359786003471 dimer interface [polypeptide binding]; other site 359786003472 motif 1; other site 359786003473 active site 359786003474 motif 2; other site 359786003475 motif 3; other site 359786003476 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 359786003477 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 359786003478 putative tRNA-binding site [nucleotide binding]; other site 359786003479 B3/4 domain; Region: B3_4; pfam03483 359786003480 tRNA synthetase B5 domain; Region: B5; smart00874 359786003481 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 359786003482 dimer interface [polypeptide binding]; other site 359786003483 motif 1; other site 359786003484 motif 3; other site 359786003485 motif 2; other site 359786003486 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 359786003487 ribonuclease HIII; Provisional; Region: PRK00996 359786003488 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 359786003489 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 359786003490 RNA/DNA hybrid binding site [nucleotide binding]; other site 359786003491 active site 359786003492 Cell division protein ZapA; Region: ZapA; cl01146 359786003493 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 359786003494 Colicin V production protein; Region: Colicin_V; pfam02674 359786003495 hypothetical protein; Provisional; Region: PRK08609 359786003496 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 359786003497 active site 359786003498 primer binding site [nucleotide binding]; other site 359786003499 NTP binding site [chemical binding]; other site 359786003500 metal binding triad [ion binding]; metal-binding site 359786003501 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 359786003502 active site 359786003503 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 359786003504 MutS domain III; Region: MutS_III; pfam05192 359786003505 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 359786003506 Walker A/P-loop; other site 359786003507 ATP binding site [chemical binding]; other site 359786003508 Q-loop/lid; other site 359786003509 ABC transporter signature motif; other site 359786003510 Walker B; other site 359786003511 D-loop; other site 359786003512 H-loop/switch region; other site 359786003513 Smr domain; Region: Smr; pfam01713 359786003514 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 359786003515 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 359786003516 catalytic residues [active] 359786003517 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 359786003518 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 359786003519 GIY-YIG motif/motif A; other site 359786003520 active site 359786003521 catalytic site [active] 359786003522 putative DNA binding site [nucleotide binding]; other site 359786003523 metal binding site [ion binding]; metal-binding site 359786003524 UvrB/uvrC motif; Region: UVR; pfam02151 359786003525 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 359786003526 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 359786003527 putative Iron-sulfur protein interface [polypeptide binding]; other site 359786003528 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 359786003529 proximal heme binding site [chemical binding]; other site 359786003530 distal heme binding site [chemical binding]; other site 359786003531 putative dimer interface [polypeptide binding]; other site 359786003532 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 359786003533 L-aspartate oxidase; Provisional; Region: PRK06175 359786003534 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 359786003535 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 359786003536 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 359786003537 glutamate racemase; Provisional; Region: PRK00865 359786003538 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 359786003539 active site 359786003540 dimerization interface [polypeptide binding]; other site 359786003541 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 359786003542 active site 359786003543 metal binding site [ion binding]; metal-binding site 359786003544 homotetramer interface [polypeptide binding]; other site 359786003545 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 359786003546 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 359786003547 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 359786003548 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 359786003549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 359786003550 Transposase; Region: DDE_Tnp_ISL3; pfam01610 359786003551 beta-channel forming cytolysin; Region: hlyII; TIGR01002 359786003552 superantigen-like protein; Reviewed; Region: PRK13350 359786003553 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786003554 superantigen-like protein; Reviewed; Region: PRK13349 359786003555 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786003556 superantigen-like protein; Reviewed; Region: PRK13043 359786003557 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786003558 ornithine carbamoyltransferase; Provisional; Region: PRK04284 359786003559 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 359786003560 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 359786003561 carbamate kinase; Reviewed; Region: PRK12686 359786003562 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 359786003563 putative substrate binding site [chemical binding]; other site 359786003564 nucleotide binding site [chemical binding]; other site 359786003565 nucleotide binding site [chemical binding]; other site 359786003566 homodimer interface [polypeptide binding]; other site 359786003567 Predicted membrane protein [Function unknown]; Region: COG1288 359786003568 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 359786003569 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 359786003570 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 359786003571 gating phenylalanine in ion channel; other site 359786003572 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 359786003573 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 359786003574 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 359786003575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786003576 motif II; other site 359786003577 hypothetical protein; Provisional; Region: PRK13688 359786003578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 359786003579 Coenzyme A binding pocket [chemical binding]; other site 359786003580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 359786003581 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 359786003582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 359786003583 MraZ protein; Region: MraZ; pfam02381 359786003584 MraZ protein; Region: MraZ; pfam02381 359786003585 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 359786003586 MraW methylase family; Region: Methyltransf_5; pfam01795 359786003587 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 359786003588 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 359786003589 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 359786003590 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 359786003591 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 359786003592 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 359786003593 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 359786003594 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 359786003595 Mg++ binding site [ion binding]; other site 359786003596 putative catalytic motif [active] 359786003597 putative substrate binding site [chemical binding]; other site 359786003598 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 359786003599 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 359786003600 NAD binding site [chemical binding]; other site 359786003601 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 359786003602 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 359786003603 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 359786003604 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 359786003605 Cell division protein FtsQ; Region: FtsQ; pfam03799 359786003606 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 359786003607 Cell division protein FtsA; Region: FtsA; smart00842 359786003608 Cell division protein FtsA; Region: FtsA; pfam14450 359786003609 cell division protein FtsZ; Validated; Region: PRK09330 359786003610 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 359786003611 nucleotide binding site [chemical binding]; other site 359786003612 SulA interaction site; other site 359786003613 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 359786003614 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 359786003615 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 359786003616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 359786003617 catalytic residue [active] 359786003618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 359786003619 YGGT family; Region: YGGT; pfam02325 359786003620 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 359786003621 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 359786003622 RNA binding surface [nucleotide binding]; other site 359786003623 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 359786003624 DivIVA domain; Region: DivI1A_domain; TIGR03544 359786003625 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 359786003626 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 359786003627 HIGH motif; other site 359786003628 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 359786003629 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 359786003630 active site 359786003631 KMSKS motif; other site 359786003632 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 359786003633 tRNA binding surface [nucleotide binding]; other site 359786003634 anticodon binding site; other site 359786003635 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 359786003636 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 359786003637 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 359786003638 active site 359786003639 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 359786003640 lipoprotein signal peptidase; Provisional; Region: PRK14787 359786003641 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 359786003642 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 359786003643 RNA binding surface [nucleotide binding]; other site 359786003644 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 359786003645 active site 359786003646 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 359786003647 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 359786003648 uracil transporter; Provisional; Region: PRK10720 359786003649 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 359786003650 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 359786003651 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 359786003652 dihydroorotase; Validated; Region: pyrC; PRK09357 359786003653 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 359786003654 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 359786003655 active site 359786003656 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 359786003657 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 359786003658 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 359786003659 catalytic site [active] 359786003660 subunit interface [polypeptide binding]; other site 359786003661 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 359786003662 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 359786003663 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 359786003664 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 359786003665 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 359786003666 ATP-grasp domain; Region: ATP-grasp_4; cl17255 359786003667 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 359786003668 IMP binding site; other site 359786003669 dimer interface [polypeptide binding]; other site 359786003670 interdomain contacts; other site 359786003671 partial ornithine binding site; other site 359786003672 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 359786003673 active site 359786003674 dimer interface [polypeptide binding]; other site 359786003675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 359786003676 active site 359786003677 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 359786003678 dimer interface [polypeptide binding]; other site 359786003679 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 359786003680 Domain of unknown function (DUF814); Region: DUF814; pfam05670 359786003681 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 359786003682 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 359786003683 catalytic site [active] 359786003684 G-X2-G-X-G-K; other site 359786003685 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 359786003686 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 359786003687 Flavoprotein; Region: Flavoprotein; pfam02441 359786003688 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 359786003689 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 359786003690 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 359786003691 ATP binding site [chemical binding]; other site 359786003692 putative Mg++ binding site [ion binding]; other site 359786003693 helicase superfamily c-terminal domain; Region: HELICc; smart00490 359786003694 nucleotide binding region [chemical binding]; other site 359786003695 ATP-binding site [chemical binding]; other site 359786003696 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 359786003697 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 359786003698 active site 359786003699 catalytic residues [active] 359786003700 metal binding site [ion binding]; metal-binding site 359786003701 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 359786003702 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 359786003703 putative active site [active] 359786003704 substrate binding site [chemical binding]; other site 359786003705 putative cosubstrate binding site; other site 359786003706 catalytic site [active] 359786003707 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 359786003708 substrate binding site [chemical binding]; other site 359786003709 16S rRNA methyltransferase B; Provisional; Region: PRK14902 359786003710 NusB family; Region: NusB; pfam01029 359786003711 putative RNA binding site [nucleotide binding]; other site 359786003712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786003713 S-adenosylmethionine binding site [chemical binding]; other site 359786003714 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 359786003715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 359786003716 FeS/SAM binding site; other site 359786003717 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 359786003718 Protein phosphatase 2C; Region: PP2C; pfam00481 359786003719 active site 359786003720 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 359786003721 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 359786003722 active site 359786003723 ATP binding site [chemical binding]; other site 359786003724 substrate binding site [chemical binding]; other site 359786003725 activation loop (A-loop); other site 359786003726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 359786003727 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 359786003728 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 359786003729 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 359786003730 Predicted GTPases [General function prediction only]; Region: COG1162 359786003731 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 359786003732 RNA binding site [nucleotide binding]; other site 359786003733 homodimer interface [polypeptide binding]; other site 359786003734 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 359786003735 GTPase/Zn-binding domain interface [polypeptide binding]; other site 359786003736 GTP/Mg2+ binding site [chemical binding]; other site 359786003737 G4 box; other site 359786003738 G5 box; other site 359786003739 G1 box; other site 359786003740 Switch I region; other site 359786003741 G2 box; other site 359786003742 G3 box; other site 359786003743 Switch II region; other site 359786003744 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 359786003745 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 359786003746 substrate binding site [chemical binding]; other site 359786003747 hexamer interface [polypeptide binding]; other site 359786003748 metal binding site [ion binding]; metal-binding site 359786003749 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 359786003750 Thiamine pyrophosphokinase; Region: TPK; cd07995 359786003751 active site 359786003752 dimerization interface [polypeptide binding]; other site 359786003753 thiamine binding site [chemical binding]; other site 359786003754 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 359786003755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 359786003756 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 359786003757 DAK2 domain; Region: Dak2; pfam02734 359786003758 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 359786003759 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 359786003760 generic binding surface II; other site 359786003761 ssDNA binding site; other site 359786003762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 359786003763 ATP binding site [chemical binding]; other site 359786003764 putative Mg++ binding site [ion binding]; other site 359786003765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 359786003766 nucleotide binding region [chemical binding]; other site 359786003767 ATP-binding site [chemical binding]; other site 359786003768 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 359786003769 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 359786003770 active site 2 [active] 359786003771 active site 1 [active] 359786003772 putative phosphate acyltransferase; Provisional; Region: PRK05331 359786003773 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 359786003774 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 359786003775 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 359786003776 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 359786003777 NAD(P) binding site [chemical binding]; other site 359786003778 homotetramer interface [polypeptide binding]; other site 359786003779 homodimer interface [polypeptide binding]; other site 359786003780 active site 359786003781 acyl carrier protein; Provisional; Region: acpP; PRK00982 359786003782 ribonuclease III; Reviewed; Region: rnc; PRK00102 359786003783 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 359786003784 dimerization interface [polypeptide binding]; other site 359786003785 active site 359786003786 metal binding site [ion binding]; metal-binding site 359786003787 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 359786003788 dsRNA binding site [nucleotide binding]; other site 359786003789 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 359786003790 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 359786003791 Walker A/P-loop; other site 359786003792 ATP binding site [chemical binding]; other site 359786003793 Q-loop/lid; other site 359786003794 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 359786003795 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 359786003796 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 359786003797 ABC transporter signature motif; other site 359786003798 Walker B; other site 359786003799 D-loop; other site 359786003800 H-loop/switch region; other site 359786003801 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 359786003802 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 359786003803 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 359786003804 P loop; other site 359786003805 GTP binding site [chemical binding]; other site 359786003806 putative DNA-binding protein; Validated; Region: PRK00118 359786003807 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 359786003808 signal recognition particle protein; Provisional; Region: PRK10867 359786003809 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 359786003810 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 359786003811 P loop; other site 359786003812 GTP binding site [chemical binding]; other site 359786003813 Signal peptide binding domain; Region: SRP_SPB; pfam02978 359786003814 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 359786003815 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 359786003816 RimM N-terminal domain; Region: RimM; pfam01782 359786003817 PRC-barrel domain; Region: PRC; pfam05239 359786003818 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 359786003819 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 359786003820 Predicted membrane protein [Function unknown]; Region: COG4485 359786003821 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 359786003822 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 359786003823 GTP/Mg2+ binding site [chemical binding]; other site 359786003824 G4 box; other site 359786003825 G5 box; other site 359786003826 G1 box; other site 359786003827 Switch I region; other site 359786003828 G2 box; other site 359786003829 G3 box; other site 359786003830 Switch II region; other site 359786003831 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 359786003832 RNA/DNA hybrid binding site [nucleotide binding]; other site 359786003833 active site 359786003834 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 359786003835 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 359786003836 CoA-ligase; Region: Ligase_CoA; pfam00549 359786003837 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 359786003838 CoA binding domain; Region: CoA_binding; pfam02629 359786003839 CoA-ligase; Region: Ligase_CoA; pfam00549 359786003840 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 359786003841 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 359786003842 CHAP domain; Region: CHAP; pfam05257 359786003843 FemAB family; Region: FemAB; pfam02388 359786003844 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 359786003845 DNA topoisomerase I; Validated; Region: PRK05582 359786003846 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 359786003847 active site 359786003848 interdomain interaction site; other site 359786003849 putative metal-binding site [ion binding]; other site 359786003850 nucleotide binding site [chemical binding]; other site 359786003851 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 359786003852 domain I; other site 359786003853 DNA binding groove [nucleotide binding] 359786003854 phosphate binding site [ion binding]; other site 359786003855 domain II; other site 359786003856 domain III; other site 359786003857 nucleotide binding site [chemical binding]; other site 359786003858 catalytic site [active] 359786003859 domain IV; other site 359786003860 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 359786003861 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 359786003862 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 359786003863 Glucose inhibited division protein A; Region: GIDA; pfam01134 359786003864 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 359786003865 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 359786003866 active site 359786003867 DNA binding site [nucleotide binding] 359786003868 Int/Topo IB signature motif; other site 359786003869 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 359786003870 active site 359786003871 HslU subunit interaction site [polypeptide binding]; other site 359786003872 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 359786003873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786003874 Walker A motif; other site 359786003875 ATP binding site [chemical binding]; other site 359786003876 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 359786003877 Walker B motif; other site 359786003878 arginine finger; other site 359786003879 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 359786003880 transcriptional repressor CodY; Validated; Region: PRK04158 359786003881 CodY GAF-like domain; Region: CodY; pfam06018 359786003882 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 359786003883 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 359786003884 rRNA interaction site [nucleotide binding]; other site 359786003885 S8 interaction site; other site 359786003886 putative laminin-1 binding site; other site 359786003887 elongation factor Ts; Provisional; Region: tsf; PRK09377 359786003888 UBA/TS-N domain; Region: UBA; pfam00627 359786003889 Elongation factor TS; Region: EF_TS; pfam00889 359786003890 Elongation factor TS; Region: EF_TS; pfam00889 359786003891 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 359786003892 putative nucleotide binding site [chemical binding]; other site 359786003893 uridine monophosphate binding site [chemical binding]; other site 359786003894 homohexameric interface [polypeptide binding]; other site 359786003895 ribosome recycling factor; Reviewed; Region: frr; PRK00083 359786003896 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 359786003897 hinge region; other site 359786003898 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 359786003899 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 359786003900 catalytic residue [active] 359786003901 putative FPP diphosphate binding site; other site 359786003902 putative FPP binding hydrophobic cleft; other site 359786003903 dimer interface [polypeptide binding]; other site 359786003904 putative IPP diphosphate binding site; other site 359786003905 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 359786003906 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 359786003907 RIP metalloprotease RseP; Region: TIGR00054 359786003908 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 359786003909 active site 359786003910 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 359786003911 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 359786003912 protein binding site [polypeptide binding]; other site 359786003913 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 359786003914 putative substrate binding region [chemical binding]; other site 359786003915 prolyl-tRNA synthetase; Provisional; Region: PRK09194 359786003916 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 359786003917 dimer interface [polypeptide binding]; other site 359786003918 motif 1; other site 359786003919 active site 359786003920 motif 2; other site 359786003921 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 359786003922 putative deacylase active site [active] 359786003923 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 359786003924 active site 359786003925 motif 3; other site 359786003926 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 359786003927 anticodon binding site; other site 359786003928 DNA polymerase III PolC; Validated; Region: polC; PRK00448 359786003929 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 359786003930 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 359786003931 generic binding surface II; other site 359786003932 generic binding surface I; other site 359786003933 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 359786003934 active site 359786003935 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 359786003936 active site 359786003937 catalytic site [active] 359786003938 substrate binding site [chemical binding]; other site 359786003939 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 359786003940 ribosome maturation protein RimP; Reviewed; Region: PRK00092 359786003941 Sm and related proteins; Region: Sm_like; cl00259 359786003942 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 359786003943 putative oligomer interface [polypeptide binding]; other site 359786003944 putative RNA binding site [nucleotide binding]; other site 359786003945 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 359786003946 NusA N-terminal domain; Region: NusA_N; pfam08529 359786003947 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 359786003948 RNA binding site [nucleotide binding]; other site 359786003949 homodimer interface [polypeptide binding]; other site 359786003950 NusA-like KH domain; Region: KH_5; pfam13184 359786003951 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 359786003952 G-X-X-G motif; other site 359786003953 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 359786003954 putative RNA binding cleft [nucleotide binding]; other site 359786003955 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 359786003956 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 359786003957 translation initiation factor IF-2; Region: IF-2; TIGR00487 359786003958 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 359786003959 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 359786003960 G1 box; other site 359786003961 putative GEF interaction site [polypeptide binding]; other site 359786003962 GTP/Mg2+ binding site [chemical binding]; other site 359786003963 Switch I region; other site 359786003964 G2 box; other site 359786003965 G3 box; other site 359786003966 Switch II region; other site 359786003967 G4 box; other site 359786003968 G5 box; other site 359786003969 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 359786003970 Translation-initiation factor 2; Region: IF-2; pfam11987 359786003971 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 359786003972 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 359786003973 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 359786003974 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 359786003975 RNA binding site [nucleotide binding]; other site 359786003976 active site 359786003977 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 359786003978 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 359786003979 active site 359786003980 Riboflavin kinase; Region: Flavokinase; smart00904 359786003981 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 359786003982 16S/18S rRNA binding site [nucleotide binding]; other site 359786003983 S13e-L30e interaction site [polypeptide binding]; other site 359786003984 25S rRNA binding site [nucleotide binding]; other site 359786003985 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 359786003986 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 359786003987 RNase E interface [polypeptide binding]; other site 359786003988 trimer interface [polypeptide binding]; other site 359786003989 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 359786003990 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 359786003991 RNase E interface [polypeptide binding]; other site 359786003992 trimer interface [polypeptide binding]; other site 359786003993 active site 359786003994 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 359786003995 putative nucleic acid binding region [nucleotide binding]; other site 359786003996 G-X-X-G motif; other site 359786003997 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 359786003998 RNA binding site [nucleotide binding]; other site 359786003999 domain interface; other site 359786004000 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 359786004001 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 359786004002 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 359786004003 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 359786004004 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 359786004005 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 359786004006 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 359786004007 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 359786004008 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 359786004009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 359786004010 DNA-binding site [nucleotide binding]; DNA binding site 359786004011 UTRA domain; Region: UTRA; pfam07702 359786004012 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 359786004013 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 359786004014 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 359786004015 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 359786004016 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 359786004017 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 359786004018 classical (c) SDRs; Region: SDR_c; cd05233 359786004019 NAD(P) binding site [chemical binding]; other site 359786004020 active site 359786004021 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 359786004022 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 359786004023 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 359786004024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786004025 non-specific DNA binding site [nucleotide binding]; other site 359786004026 salt bridge; other site 359786004027 sequence-specific DNA binding site [nucleotide binding]; other site 359786004028 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 359786004029 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 359786004030 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 359786004031 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 359786004032 putative MPT binding site; other site 359786004033 recombinase A; Provisional; Region: recA; PRK09354 359786004034 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 359786004035 hexamer interface [polypeptide binding]; other site 359786004036 Walker A motif; other site 359786004037 ATP binding site [chemical binding]; other site 359786004038 Walker B motif; other site 359786004039 phosphodiesterase; Provisional; Region: PRK12704 359786004040 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 359786004041 Zn2+ binding site [ion binding]; other site 359786004042 Mg2+ binding site [ion binding]; other site 359786004043 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 359786004044 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 359786004045 putative active site [active] 359786004046 metal binding site [ion binding]; metal-binding site 359786004047 homodimer binding site [polypeptide binding]; other site 359786004048 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 359786004049 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 359786004050 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 359786004051 dimer interface [polypeptide binding]; other site 359786004052 PYR/PP interface [polypeptide binding]; other site 359786004053 TPP binding site [chemical binding]; other site 359786004054 substrate binding site [chemical binding]; other site 359786004055 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 359786004056 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 359786004057 TPP-binding site [chemical binding]; other site 359786004058 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 359786004059 Uncharacterized conserved protein [Function unknown]; Region: COG0011 359786004060 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 359786004061 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 359786004062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 359786004063 FeS/SAM binding site; other site 359786004064 TRAM domain; Region: TRAM; pfam01938 359786004065 Predicted membrane protein [Function unknown]; Region: COG4550 359786004066 Predicted membrane protein [Function unknown]; Region: COG4732 359786004067 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 359786004068 MutS domain I; Region: MutS_I; pfam01624 359786004069 MutS domain II; Region: MutS_II; pfam05188 359786004070 MutS domain III; Region: MutS_III; pfam05192 359786004071 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 359786004072 Walker A/P-loop; other site 359786004073 ATP binding site [chemical binding]; other site 359786004074 Q-loop/lid; other site 359786004075 ABC transporter signature motif; other site 359786004076 Walker B; other site 359786004077 D-loop; other site 359786004078 H-loop/switch region; other site 359786004079 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 359786004080 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 359786004081 amphipathic channel; other site 359786004082 Asn-Pro-Ala signature motifs; other site 359786004083 glycerol kinase; Provisional; Region: glpK; PRK00047 359786004084 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 359786004085 N- and C-terminal domain interface [polypeptide binding]; other site 359786004086 active site 359786004087 MgATP binding site [chemical binding]; other site 359786004088 catalytic site [active] 359786004089 metal binding site [ion binding]; metal-binding site 359786004090 glycerol binding site [chemical binding]; other site 359786004091 homotetramer interface [polypeptide binding]; other site 359786004092 homodimer interface [polypeptide binding]; other site 359786004093 FBP binding site [chemical binding]; other site 359786004094 protein IIAGlc interface [polypeptide binding]; other site 359786004095 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 359786004096 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 359786004097 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 359786004098 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 359786004099 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 359786004100 bacterial Hfq-like; Region: Hfq; cd01716 359786004101 hexamer interface [polypeptide binding]; other site 359786004102 Sm1 motif; other site 359786004103 RNA binding site [nucleotide binding]; other site 359786004104 Sm2 motif; other site 359786004105 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 359786004106 catalytic residues [active] 359786004107 dimer interface [polypeptide binding]; other site 359786004108 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 359786004109 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 359786004110 HflX GTPase family; Region: HflX; cd01878 359786004111 G1 box; other site 359786004112 GTP/Mg2+ binding site [chemical binding]; other site 359786004113 Switch I region; other site 359786004114 G2 box; other site 359786004115 G3 box; other site 359786004116 Switch II region; other site 359786004117 G4 box; other site 359786004118 G5 box; other site 359786004119 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 359786004120 Aluminium resistance protein; Region: Alum_res; pfam06838 359786004121 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 359786004122 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 359786004123 DNA binding residues [nucleotide binding] 359786004124 putative dimer interface [polypeptide binding]; other site 359786004125 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 359786004126 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 359786004127 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 359786004128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 359786004129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 359786004130 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 359786004131 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 359786004132 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 359786004133 catalytic residue [active] 359786004134 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 359786004135 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 359786004136 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 359786004137 putative active site [active] 359786004138 catalytic site [active] 359786004139 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 359786004140 putative active site [active] 359786004141 catalytic site [active] 359786004142 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 359786004143 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 359786004144 Walker A/P-loop; other site 359786004145 ATP binding site [chemical binding]; other site 359786004146 Q-loop/lid; other site 359786004147 ABC transporter signature motif; other site 359786004148 Walker B; other site 359786004149 D-loop; other site 359786004150 H-loop/switch region; other site 359786004151 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 359786004152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 359786004153 Histidine kinase; Region: HisKA_3; pfam07730 359786004154 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 359786004155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 359786004156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786004157 active site 359786004158 phosphorylation site [posttranslational modification] 359786004159 intermolecular recognition site; other site 359786004160 dimerization interface [polypeptide binding]; other site 359786004161 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 359786004162 DNA binding residues [nucleotide binding] 359786004163 dimerization interface [polypeptide binding]; other site 359786004164 Staphylococcal nuclease homologues; Region: SNc; smart00318 359786004165 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 359786004166 Catalytic site; other site 359786004167 AAA domain; Region: AAA_11; pfam13086 359786004168 aspartate kinase; Reviewed; Region: PRK09034 359786004169 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 359786004170 putative catalytic residues [active] 359786004171 putative nucleotide binding site [chemical binding]; other site 359786004172 putative aspartate binding site [chemical binding]; other site 359786004173 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 359786004174 allosteric regulatory residue; other site 359786004175 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 359786004176 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 359786004177 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 359786004178 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 359786004179 threonine synthase; Reviewed; Region: PRK06721 359786004180 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 359786004181 homodimer interface [polypeptide binding]; other site 359786004182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786004183 catalytic residue [active] 359786004184 homoserine kinase; Provisional; Region: PRK01212 359786004185 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 359786004186 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 359786004187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786004188 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 359786004189 active site 359786004190 motif I; other site 359786004191 motif II; other site 359786004192 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 359786004193 lysine transporter; Provisional; Region: PRK10836 359786004194 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 359786004195 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 359786004196 tetramer interface [polypeptide binding]; other site 359786004197 heme binding pocket [chemical binding]; other site 359786004198 NADPH binding site [chemical binding]; other site 359786004199 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 359786004200 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 359786004201 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 359786004202 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 359786004203 active site 359786004204 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 359786004205 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 359786004206 LexA repressor; Validated; Region: PRK00215 359786004207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 359786004208 putative DNA binding site [nucleotide binding]; other site 359786004209 putative Zn2+ binding site [ion binding]; other site 359786004210 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 359786004211 Catalytic site [active] 359786004212 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 359786004213 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 359786004214 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 359786004215 TPP-binding site [chemical binding]; other site 359786004216 dimer interface [polypeptide binding]; other site 359786004217 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 359786004218 PYR/PP interface [polypeptide binding]; other site 359786004219 dimer interface [polypeptide binding]; other site 359786004220 TPP binding site [chemical binding]; other site 359786004221 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 359786004222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 359786004223 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 359786004224 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 359786004225 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 359786004226 active site 359786004227 metal binding site [ion binding]; metal-binding site 359786004228 DNA binding site [nucleotide binding] 359786004229 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 359786004230 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 359786004231 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 359786004232 Walker A/P-loop; other site 359786004233 ATP binding site [chemical binding]; other site 359786004234 Q-loop/lid; other site 359786004235 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 359786004236 ABC transporter signature motif; other site 359786004237 Walker B; other site 359786004238 D-loop; other site 359786004239 H-loop/switch region; other site 359786004240 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 359786004241 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 359786004242 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 359786004243 aconitate hydratase; Validated; Region: PRK09277 359786004244 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 359786004245 substrate binding site [chemical binding]; other site 359786004246 ligand binding site [chemical binding]; other site 359786004247 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 359786004248 substrate binding site [chemical binding]; other site 359786004249 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 359786004250 active site 359786004251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 359786004252 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 359786004253 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 359786004254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786004255 ATP binding site [chemical binding]; other site 359786004256 Mg2+ binding site [ion binding]; other site 359786004257 G-X-G motif; other site 359786004258 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 359786004259 anchoring element; other site 359786004260 dimer interface [polypeptide binding]; other site 359786004261 ATP binding site [chemical binding]; other site 359786004262 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 359786004263 active site 359786004264 putative metal-binding site [ion binding]; other site 359786004265 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 359786004266 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 359786004267 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 359786004268 CAP-like domain; other site 359786004269 active site 359786004270 primary dimer interface [polypeptide binding]; other site 359786004271 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 359786004272 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 359786004273 amino acid carrier protein; Region: agcS; TIGR00835 359786004274 CAT RNA binding domain; Region: CAT_RBD; smart01061 359786004275 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 359786004276 PRD domain; Region: PRD; pfam00874 359786004277 PRD domain; Region: PRD; pfam00874 359786004278 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 359786004279 Domain of unknown function DUF20; Region: UPF0118; pfam01594 359786004280 Predicted integral membrane protein [Function unknown]; Region: COG0392 359786004281 Uncharacterized conserved protein [Function unknown]; Region: COG2898 359786004282 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 359786004283 methionine sulfoxide reductase A; Provisional; Region: PRK14054 359786004284 Transcriptional regulator [Transcription]; Region: LytR; COG1316 359786004285 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 359786004286 active site 1 [active] 359786004287 dimer interface [polypeptide binding]; other site 359786004288 hexamer interface [polypeptide binding]; other site 359786004289 active site 2 [active] 359786004290 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 359786004291 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 359786004292 active site 359786004293 DNA binding site [nucleotide binding] 359786004294 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 359786004295 prephenate dehydrogenase; Validated; Region: PRK06545 359786004296 prephenate dehydrogenase; Validated; Region: PRK08507 359786004297 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 359786004298 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 359786004299 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 359786004300 putative oligomer interface [polypeptide binding]; other site 359786004301 putative active site [active] 359786004302 metal binding site [ion binding]; metal-binding site 359786004303 anthranilate synthase component I; Provisional; Region: PRK13567 359786004304 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 359786004305 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 359786004306 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 359786004307 Glutamine amidotransferase class-I; Region: GATase; pfam00117 359786004308 glutamine binding [chemical binding]; other site 359786004309 catalytic triad [active] 359786004310 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 359786004311 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 359786004312 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 359786004313 active site 359786004314 ribulose/triose binding site [chemical binding]; other site 359786004315 phosphate binding site [ion binding]; other site 359786004316 substrate (anthranilate) binding pocket [chemical binding]; other site 359786004317 product (indole) binding pocket [chemical binding]; other site 359786004318 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 359786004319 active site 359786004320 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 359786004321 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 359786004322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786004323 catalytic residue [active] 359786004324 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 359786004325 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 359786004326 substrate binding site [chemical binding]; other site 359786004327 active site 359786004328 catalytic residues [active] 359786004329 heterodimer interface [polypeptide binding]; other site 359786004330 FemAB family; Region: FemAB; pfam02388 359786004331 FlxA-like protein; Region: FlxA; pfam14282 359786004332 FemAB family; Region: FemAB; pfam02388 359786004333 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 359786004334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786004335 active site 359786004336 motif I; other site 359786004337 motif II; other site 359786004338 SWIM zinc finger; Region: SWIM; pfam04434 359786004339 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 359786004340 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 359786004341 Walker A/P-loop; other site 359786004342 ATP binding site [chemical binding]; other site 359786004343 Q-loop/lid; other site 359786004344 ABC transporter signature motif; other site 359786004345 Walker B; other site 359786004346 D-loop; other site 359786004347 H-loop/switch region; other site 359786004348 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 359786004349 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 359786004350 Walker A/P-loop; other site 359786004351 ATP binding site [chemical binding]; other site 359786004352 Q-loop/lid; other site 359786004353 ABC transporter signature motif; other site 359786004354 Walker B; other site 359786004355 D-loop; other site 359786004356 H-loop/switch region; other site 359786004357 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 359786004358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786004359 dimer interface [polypeptide binding]; other site 359786004360 conserved gate region; other site 359786004361 putative PBP binding loops; other site 359786004362 ABC-ATPase subunit interface; other site 359786004363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 359786004364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786004365 dimer interface [polypeptide binding]; other site 359786004366 conserved gate region; other site 359786004367 putative PBP binding loops; other site 359786004368 ABC-ATPase subunit interface; other site 359786004369 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 359786004370 oligoendopeptidase F; Region: pepF; TIGR00181 359786004371 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 359786004372 active site 359786004373 Zn binding site [ion binding]; other site 359786004374 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 359786004375 PhoU domain; Region: PhoU; pfam01895 359786004376 PhoU domain; Region: PhoU; pfam01895 359786004377 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 359786004378 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 359786004379 Walker A/P-loop; other site 359786004380 ATP binding site [chemical binding]; other site 359786004381 Q-loop/lid; other site 359786004382 ABC transporter signature motif; other site 359786004383 Walker B; other site 359786004384 D-loop; other site 359786004385 H-loop/switch region; other site 359786004386 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 359786004387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786004388 dimer interface [polypeptide binding]; other site 359786004389 conserved gate region; other site 359786004390 putative PBP binding loops; other site 359786004391 ABC-ATPase subunit interface; other site 359786004392 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 359786004393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786004394 dimer interface [polypeptide binding]; other site 359786004395 conserved gate region; other site 359786004396 ABC-ATPase subunit interface; other site 359786004397 phosphate binding protein; Region: ptsS_2; TIGR02136 359786004398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 359786004399 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 359786004400 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 359786004401 S1 domain; Region: S1_2; pfam13509 359786004402 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 359786004403 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 359786004404 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 359786004405 ABC transporter; Region: ABC_tran_2; pfam12848 359786004406 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 359786004407 aspartate kinase; Reviewed; Region: PRK06635 359786004408 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 359786004409 putative nucleotide binding site [chemical binding]; other site 359786004410 putative catalytic residues [active] 359786004411 putative Mg ion binding site [ion binding]; other site 359786004412 putative aspartate binding site [chemical binding]; other site 359786004413 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 359786004414 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 359786004415 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 359786004416 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 359786004417 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 359786004418 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 359786004419 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 359786004420 dimer interface [polypeptide binding]; other site 359786004421 active site 359786004422 catalytic residue [active] 359786004423 dihydrodipicolinate reductase; Provisional; Region: PRK00048 359786004424 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 359786004425 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 359786004426 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 359786004427 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 359786004428 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 359786004429 active site 359786004430 trimer interface [polypeptide binding]; other site 359786004431 substrate binding site [chemical binding]; other site 359786004432 CoA binding site [chemical binding]; other site 359786004433 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 359786004434 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 359786004435 metal binding site [ion binding]; metal-binding site 359786004436 dimer interface [polypeptide binding]; other site 359786004437 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 359786004438 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 359786004439 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 359786004440 catalytic residue [active] 359786004441 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 359786004442 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 359786004443 active site 359786004444 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 359786004445 substrate binding site [chemical binding]; other site 359786004446 catalytic residues [active] 359786004447 dimer interface [polypeptide binding]; other site 359786004448 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 359786004449 DNA-binding site [nucleotide binding]; DNA binding site 359786004450 RNA-binding motif; other site 359786004451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 359786004452 acylphosphatase; Provisional; Region: PRK14431 359786004453 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 359786004454 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 359786004455 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 359786004456 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 359786004457 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 359786004458 metal ion-dependent adhesion site (MIDAS); other site 359786004459 MoxR-like ATPases [General function prediction only]; Region: COG0714 359786004460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786004461 Walker A motif; other site 359786004462 ATP binding site [chemical binding]; other site 359786004463 Walker B motif; other site 359786004464 arginine finger; other site 359786004465 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 359786004466 active site 359786004467 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 359786004468 active site 359786004469 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 359786004470 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 359786004471 E3 interaction surface; other site 359786004472 lipoyl attachment site [posttranslational modification]; other site 359786004473 e3 binding domain; Region: E3_binding; pfam02817 359786004474 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 359786004475 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 359786004476 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 359786004477 TPP-binding site [chemical binding]; other site 359786004478 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 359786004479 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 359786004480 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 359786004481 HAMP domain; Region: HAMP; pfam00672 359786004482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 359786004483 dimer interface [polypeptide binding]; other site 359786004484 phosphorylation site [posttranslational modification] 359786004485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786004486 ATP binding site [chemical binding]; other site 359786004487 Mg2+ binding site [ion binding]; other site 359786004488 G-X-G motif; other site 359786004489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 359786004490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786004491 active site 359786004492 phosphorylation site [posttranslational modification] 359786004493 intermolecular recognition site; other site 359786004494 dimerization interface [polypeptide binding]; other site 359786004495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 359786004496 DNA binding site [nucleotide binding] 359786004497 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 359786004498 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 359786004499 active site 359786004500 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 359786004501 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 359786004502 active site 359786004503 homodimer interface [polypeptide binding]; other site 359786004504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786004505 Coenzyme A binding pocket [chemical binding]; other site 359786004506 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 359786004507 C-terminal peptidase (prc); Region: prc; TIGR00225 359786004508 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 359786004509 protein binding site [polypeptide binding]; other site 359786004510 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 359786004511 Catalytic dyad [active] 359786004512 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 359786004513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 359786004514 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 359786004515 HPr interaction site; other site 359786004516 glycerol kinase (GK) interaction site [polypeptide binding]; other site 359786004517 active site 359786004518 phosphorylation site [posttranslational modification] 359786004519 methionine sulfoxide reductase B; Provisional; Region: PRK00222 359786004520 SelR domain; Region: SelR; pfam01641 359786004521 methionine sulfoxide reductase A; Provisional; Region: PRK13014 359786004522 EDD domain protein, DegV family; Region: DegV; TIGR00762 359786004523 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 359786004524 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 359786004525 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 359786004526 folate binding site [chemical binding]; other site 359786004527 NADP+ binding site [chemical binding]; other site 359786004528 thymidylate synthase; Region: thym_sym; TIGR03284 359786004529 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 359786004530 dimerization interface [polypeptide binding]; other site 359786004531 active site 359786004532 Disulphide isomerase; Region: Disulph_isomer; pfam06491 359786004533 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 359786004534 Virulence factor; Region: Virulence_fact; pfam13769 359786004535 HEAT repeats; Region: HEAT_2; pfam13646 359786004536 HEAT repeat; Region: HEAT; pfam02985 359786004537 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 359786004538 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 359786004539 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 359786004540 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 359786004541 RNA/DNA hybrid binding site [nucleotide binding]; other site 359786004542 active site 359786004543 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786004544 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 359786004545 GA module; Region: GA; smart00844 359786004546 GA module; Region: GA; smart00844 359786004547 GA module; Region: GA; smart00844 359786004548 GA module; Region: GA; smart00844 359786004549 GA module; Region: GA; smart00844 359786004550 GA module; Region: GA; smart00844 359786004551 GA module; Region: GA; smart00844 359786004552 GA module; Region: GA; smart00844 359786004553 GA module; Region: GA; smart00844 359786004554 GA module; Region: GA; smart00844 359786004555 GA module; Region: GA; smart00844 359786004556 GA module; Region: GA; smart00844 359786004557 GA module; Region: GA; smart00844 359786004558 GA module; Region: GA; smart00844 359786004559 GA module; Region: GA; smart00844 359786004560 GA module; Region: GA; smart00844 359786004561 GA module; Region: GA; smart00844 359786004562 GA module; Region: GA; smart00844 359786004563 GA module; Region: GA; smart00844 359786004564 GA module; Region: GA; smart00844 359786004565 GA module; Region: GA; smart00844 359786004566 GA module; Region: GA; smart00844 359786004567 GA module; Region: GA; smart00844 359786004568 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 359786004569 GA module; Region: GA; smart00844 359786004570 GA module; Region: GA; smart00844 359786004571 GA module; Region: GA; pfam01468 359786004572 GA module; Region: GA; smart00844 359786004573 GA module; Region: GA; smart00844 359786004574 GA module; Region: GA; smart00844 359786004575 GA module; Region: GA; smart00844 359786004576 GA module; Region: GA; pfam01468 359786004577 GA module; Region: GA; smart00844 359786004578 GA module; Region: GA; smart00844 359786004579 GA module; Region: GA; smart00844 359786004580 GA module; Region: GA; smart00844 359786004581 GA module; Region: GA; smart00844 359786004582 GA module; Region: GA; smart00844 359786004583 chromosome segregation protein; Provisional; Region: PRK02224 359786004584 GA module; Region: GA; smart00844 359786004585 GA module; Region: GA; smart00844 359786004586 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 359786004587 GA module; Region: GA; pfam01468 359786004588 GA module; Region: GA; smart00844 359786004589 GA module; Region: GA; smart00844 359786004590 GA module; Region: GA; smart00844 359786004591 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786004592 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786004593 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 359786004594 Amino acid permease; Region: AA_permease_2; pfam13520 359786004595 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 359786004596 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 359786004597 tetramer interface [polypeptide binding]; other site 359786004598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786004599 catalytic residue [active] 359786004600 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 359786004601 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 359786004602 hexamer interface [polypeptide binding]; other site 359786004603 ligand binding site [chemical binding]; other site 359786004604 putative active site [active] 359786004605 NAD(P) binding site [chemical binding]; other site 359786004606 5'-3' exonuclease; Region: 53EXOc; smart00475 359786004607 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 359786004608 active site 359786004609 metal binding site 1 [ion binding]; metal-binding site 359786004610 putative 5' ssDNA interaction site; other site 359786004611 metal binding site 3; metal-binding site 359786004612 metal binding site 2 [ion binding]; metal-binding site 359786004613 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 359786004614 putative DNA binding site [nucleotide binding]; other site 359786004615 putative metal binding site [ion binding]; other site 359786004616 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 359786004617 Dynamin family; Region: Dynamin_N; pfam00350 359786004618 G1 box; other site 359786004619 GTP/Mg2+ binding site [chemical binding]; other site 359786004620 G2 box; other site 359786004621 Switch I region; other site 359786004622 G3 box; other site 359786004623 Switch II region; other site 359786004624 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 359786004625 G4 box; other site 359786004626 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 359786004627 Dynamin family; Region: Dynamin_N; pfam00350 359786004628 G1 box; other site 359786004629 GTP/Mg2+ binding site [chemical binding]; other site 359786004630 G2 box; other site 359786004631 Switch I region; other site 359786004632 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 359786004633 G3 box; other site 359786004634 Switch II region; other site 359786004635 GTP/Mg2+ binding site [chemical binding]; other site 359786004636 G4 box; other site 359786004637 G5 box; other site 359786004638 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 359786004639 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 359786004640 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 359786004641 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 359786004642 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 359786004643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 359786004644 cell division protein GpsB; Provisional; Region: PRK14127 359786004645 DivIVA domain; Region: DivI1A_domain; TIGR03544 359786004646 hypothetical protein; Provisional; Region: PRK13660 359786004647 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 359786004648 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 359786004649 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 359786004650 Transglycosylase; Region: Transgly; pfam00912 359786004651 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 359786004652 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 359786004653 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 359786004654 minor groove reading motif; other site 359786004655 helix-hairpin-helix signature motif; other site 359786004656 substrate binding pocket [chemical binding]; other site 359786004657 active site 359786004658 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 359786004659 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 359786004660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 359786004661 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 359786004662 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 359786004663 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 359786004664 putative dimer interface [polypeptide binding]; other site 359786004665 putative anticodon binding site; other site 359786004666 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 359786004667 homodimer interface [polypeptide binding]; other site 359786004668 motif 1; other site 359786004669 motif 2; other site 359786004670 active site 359786004671 motif 3; other site 359786004672 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 359786004673 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 359786004674 active site 359786004675 catalytic site [active] 359786004676 substrate binding site [chemical binding]; other site 359786004677 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 359786004678 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 359786004679 Biotin operon repressor [Transcription]; Region: BirA; COG1654 359786004680 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 359786004681 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 359786004682 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 359786004683 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 359786004684 active site 359786004685 NTP binding site [chemical binding]; other site 359786004686 metal binding triad [ion binding]; metal-binding site 359786004687 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 359786004688 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 359786004689 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 359786004690 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 359786004691 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 359786004692 homodimer interface [polypeptide binding]; other site 359786004693 metal binding site [ion binding]; metal-binding site 359786004694 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 359786004695 Predicted membrane protein [Function unknown]; Region: COG4347 359786004696 Uncharacterized conserved protein [Function unknown]; Region: COG5582 359786004697 UPF0302 domain; Region: UPF0302; pfam08864 359786004698 A short protein domain of unknown function; Region: IDEAL; smart00914 359786004699 TPR repeat; Region: TPR_11; pfam13414 359786004700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 359786004701 binding surface 359786004702 TPR motif; other site 359786004703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 359786004704 TPR motif; other site 359786004705 binding surface 359786004706 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 359786004707 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 359786004708 hinge; other site 359786004709 active site 359786004710 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 359786004711 active site 359786004712 NAD binding site [chemical binding]; other site 359786004713 metal binding site [ion binding]; metal-binding site 359786004714 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 359786004715 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 359786004716 Tetramer interface [polypeptide binding]; other site 359786004717 active site 359786004718 FMN-binding site [chemical binding]; other site 359786004719 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 359786004720 active site 359786004721 multimer interface [polypeptide binding]; other site 359786004722 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 359786004723 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 359786004724 substrate binding pocket [chemical binding]; other site 359786004725 chain length determination region; other site 359786004726 substrate-Mg2+ binding site; other site 359786004727 catalytic residues [active] 359786004728 aspartate-rich region 1; other site 359786004729 active site lid residues [active] 359786004730 aspartate-rich region 2; other site 359786004731 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 359786004732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786004733 S-adenosylmethionine binding site [chemical binding]; other site 359786004734 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 359786004735 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 359786004736 IHF dimer interface [polypeptide binding]; other site 359786004737 IHF - DNA interface [nucleotide binding]; other site 359786004738 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 359786004739 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 359786004740 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 359786004741 GTP-binding protein Der; Reviewed; Region: PRK00093 359786004742 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 359786004743 G1 box; other site 359786004744 GTP/Mg2+ binding site [chemical binding]; other site 359786004745 Switch I region; other site 359786004746 G2 box; other site 359786004747 Switch II region; other site 359786004748 G3 box; other site 359786004749 G4 box; other site 359786004750 G5 box; other site 359786004751 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 359786004752 G1 box; other site 359786004753 GTP/Mg2+ binding site [chemical binding]; other site 359786004754 Switch I region; other site 359786004755 G2 box; other site 359786004756 G3 box; other site 359786004757 Switch II region; other site 359786004758 G4 box; other site 359786004759 G5 box; other site 359786004760 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 359786004761 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 359786004762 RNA binding site [nucleotide binding]; other site 359786004763 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 359786004764 RNA binding site [nucleotide binding]; other site 359786004765 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 359786004766 RNA binding site [nucleotide binding]; other site 359786004767 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 359786004768 RNA binding site [nucleotide binding]; other site 359786004769 cytidylate kinase; Provisional; Region: cmk; PRK00023 359786004770 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 359786004771 CMP-binding site; other site 359786004772 The sites determining sugar specificity; other site 359786004773 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 359786004774 active site 359786004775 homotetramer interface [polypeptide binding]; other site 359786004776 homodimer interface [polypeptide binding]; other site 359786004777 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 359786004778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 359786004779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786004780 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 359786004781 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 359786004782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 359786004783 ATP binding site [chemical binding]; other site 359786004784 putative Mg++ binding site [ion binding]; other site 359786004785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 359786004786 nucleotide binding region [chemical binding]; other site 359786004787 ATP-binding site [chemical binding]; other site 359786004788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 359786004789 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 359786004790 Predicted membrane protein [Function unknown]; Region: COG3601 359786004791 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 359786004792 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 359786004793 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 359786004794 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 359786004795 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 359786004796 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 359786004797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 359786004798 dimerization interface [polypeptide binding]; other site 359786004799 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 359786004800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 359786004801 dimer interface [polypeptide binding]; other site 359786004802 phosphorylation site [posttranslational modification] 359786004803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786004804 ATP binding site [chemical binding]; other site 359786004805 Mg2+ binding site [ion binding]; other site 359786004806 G-X-G motif; other site 359786004807 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 359786004808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786004809 active site 359786004810 phosphorylation site [posttranslational modification] 359786004811 intermolecular recognition site; other site 359786004812 dimerization interface [polypeptide binding]; other site 359786004813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 359786004814 DNA binding site [nucleotide binding] 359786004815 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 359786004816 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 359786004817 RNA binding surface [nucleotide binding]; other site 359786004818 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 359786004819 active site 359786004820 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 359786004821 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 359786004822 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 359786004823 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 359786004824 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 359786004825 active site 359786004826 Int/Topo IB signature motif; other site 359786004827 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 359786004828 metal binding site 2 [ion binding]; metal-binding site 359786004829 putative DNA binding helix; other site 359786004830 metal binding site 1 [ion binding]; metal-binding site 359786004831 dimer interface [polypeptide binding]; other site 359786004832 structural Zn2+ binding site [ion binding]; other site 359786004833 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 359786004834 dimer interface [polypeptide binding]; other site 359786004835 ADP-ribose binding site [chemical binding]; other site 359786004836 active site 359786004837 nudix motif; other site 359786004838 metal binding site [ion binding]; metal-binding site 359786004839 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 359786004840 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 359786004841 active site 359786004842 catalytic tetrad [active] 359786004843 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 359786004844 classical (c) SDRs; Region: SDR_c; cd05233 359786004845 NAD(P) binding site [chemical binding]; other site 359786004846 active site 359786004847 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 359786004848 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 359786004849 ribonuclease Z; Region: RNase_Z; TIGR02651 359786004850 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 359786004851 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 359786004852 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 359786004853 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 359786004854 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 359786004855 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 359786004856 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 359786004857 Ca binding site [ion binding]; other site 359786004858 active site 359786004859 catalytic site [active] 359786004860 Transcriptional regulators [Transcription]; Region: PurR; COG1609 359786004861 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 359786004862 DNA binding site [nucleotide binding] 359786004863 domain linker motif; other site 359786004864 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 359786004865 putative ligand binding site [chemical binding]; other site 359786004866 putative dimerization interface [polypeptide binding]; other site 359786004867 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 359786004868 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 359786004869 H+ Antiporter protein; Region: 2A0121; TIGR00900 359786004870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786004871 putative substrate translocation pore; other site 359786004872 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 359786004873 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 359786004874 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 359786004875 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 359786004876 peptidase T-like protein; Region: PepT-like; TIGR01883 359786004877 metal binding site [ion binding]; metal-binding site 359786004878 putative dimer interface [polypeptide binding]; other site 359786004879 Predicted membrane protein [Function unknown]; Region: COG4129 359786004880 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 359786004881 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 359786004882 Disulphide isomerase; Region: Disulph_isomer; pfam06491 359786004883 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 359786004884 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 359786004885 E3 interaction surface; other site 359786004886 lipoyl attachment site [posttranslational modification]; other site 359786004887 e3 binding domain; Region: E3_binding; pfam02817 359786004888 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 359786004889 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 359786004890 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 359786004891 alpha subunit interface [polypeptide binding]; other site 359786004892 TPP binding site [chemical binding]; other site 359786004893 heterodimer interface [polypeptide binding]; other site 359786004894 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 359786004895 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 359786004896 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 359786004897 tetramer interface [polypeptide binding]; other site 359786004898 TPP-binding site [chemical binding]; other site 359786004899 heterodimer interface [polypeptide binding]; other site 359786004900 phosphorylation loop region [posttranslational modification] 359786004901 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 359786004902 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 359786004903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786004904 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 359786004905 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 359786004906 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 359786004907 Walker A/P-loop; other site 359786004908 ATP binding site [chemical binding]; other site 359786004909 Q-loop/lid; other site 359786004910 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 359786004911 ABC transporter signature motif; other site 359786004912 Walker B; other site 359786004913 D-loop; other site 359786004914 H-loop/switch region; other site 359786004915 arginine repressor; Provisional; Region: PRK04280 359786004916 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 359786004917 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 359786004918 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 359786004919 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 359786004920 substrate binding pocket [chemical binding]; other site 359786004921 chain length determination region; other site 359786004922 substrate-Mg2+ binding site; other site 359786004923 catalytic residues [active] 359786004924 aspartate-rich region 1; other site 359786004925 active site lid residues [active] 359786004926 aspartate-rich region 2; other site 359786004927 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 359786004928 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 359786004929 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 359786004930 generic binding surface II; other site 359786004931 generic binding surface I; other site 359786004932 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 359786004933 putative RNA binding site [nucleotide binding]; other site 359786004934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 359786004935 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 359786004936 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 359786004937 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 359786004938 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 359786004939 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 359786004940 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 359786004941 carboxyltransferase (CT) interaction site; other site 359786004942 biotinylation site [posttranslational modification]; other site 359786004943 elongation factor P; Validated; Region: PRK00529 359786004944 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 359786004945 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 359786004946 RNA binding site [nucleotide binding]; other site 359786004947 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 359786004948 RNA binding site [nucleotide binding]; other site 359786004949 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 359786004950 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 359786004951 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 359786004952 active site 359786004953 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 359786004954 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 359786004955 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 359786004956 active site residue [active] 359786004957 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 359786004958 tetramer interface [polypeptide binding]; other site 359786004959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786004960 catalytic residue [active] 359786004961 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 359786004962 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 359786004963 tetramer interface [polypeptide binding]; other site 359786004964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786004965 catalytic residue [active] 359786004966 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 359786004967 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 359786004968 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 359786004969 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 359786004970 ADP binding site [chemical binding]; other site 359786004971 magnesium binding site [ion binding]; other site 359786004972 putative shikimate binding site; other site 359786004973 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 359786004974 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 359786004975 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 359786004976 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 359786004977 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 359786004978 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 359786004979 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 359786004980 Type II/IV secretion system protein; Region: T2SE; pfam00437 359786004981 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 359786004982 Walker A motif; other site 359786004983 ATP binding site [chemical binding]; other site 359786004984 Walker B motif; other site 359786004985 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 359786004986 Uncharacterized conserved protein [Function unknown]; Region: COG0011 359786004987 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 359786004988 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 359786004989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 359786004990 Rhomboid family; Region: Rhomboid; pfam01694 359786004991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 359786004992 binding surface 359786004993 TPR motif; other site 359786004994 Tetratricopeptide repeat; Region: TPR_16; pfam13432 359786004995 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 359786004996 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 359786004997 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 359786004998 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 359786004999 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 359786005000 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 359786005001 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 359786005002 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 359786005003 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 359786005004 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 359786005005 metal binding site 2 [ion binding]; metal-binding site 359786005006 putative DNA binding helix; other site 359786005007 metal binding site 1 [ion binding]; metal-binding site 359786005008 dimer interface [polypeptide binding]; other site 359786005009 structural Zn2+ binding site [ion binding]; other site 359786005010 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 359786005011 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786005012 ABC-ATPase subunit interface; other site 359786005013 dimer interface [polypeptide binding]; other site 359786005014 putative PBP binding regions; other site 359786005015 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 359786005016 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 359786005017 endonuclease IV; Provisional; Region: PRK01060 359786005018 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 359786005019 AP (apurinic/apyrimidinic) site pocket; other site 359786005020 DNA interaction; other site 359786005021 Metal-binding active site; metal-binding site 359786005022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 359786005023 DEAD-like helicases superfamily; Region: DEXDc; smart00487 359786005024 ATP binding site [chemical binding]; other site 359786005025 putative Mg++ binding site [ion binding]; other site 359786005026 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 359786005027 nucleotide binding region [chemical binding]; other site 359786005028 ATP-binding site [chemical binding]; other site 359786005029 Uncharacterized conserved protein [Function unknown]; Region: COG0327 359786005030 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 359786005031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 359786005032 Uncharacterized conserved protein [Function unknown]; Region: COG0327 359786005033 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 359786005034 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 359786005035 Family of unknown function (DUF633); Region: DUF633; pfam04816 359786005036 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 359786005037 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 359786005038 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 359786005039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 359786005040 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 359786005041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 359786005042 DNA binding residues [nucleotide binding] 359786005043 DNA primase, catalytic core; Region: dnaG; TIGR01391 359786005044 CHC2 zinc finger; Region: zf-CHC2; pfam01807 359786005045 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 359786005046 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 359786005047 active site 359786005048 metal binding site [ion binding]; metal-binding site 359786005049 interdomain interaction site; other site 359786005050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 359786005051 HTH domain; Region: HTH_11; cl17392 359786005052 FOG: CBS domain [General function prediction only]; Region: COG0517 359786005053 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 359786005054 glycyl-tRNA synthetase; Provisional; Region: PRK04173 359786005055 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 359786005056 motif 1; other site 359786005057 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 359786005058 active site 359786005059 motif 2; other site 359786005060 motif 3; other site 359786005061 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 359786005062 anticodon binding site; other site 359786005063 DNA repair protein RecO; Region: reco; TIGR00613 359786005064 Recombination protein O N terminal; Region: RecO_N; pfam11967 359786005065 Recombination protein O C terminal; Region: RecO_C; pfam02565 359786005066 GTPase Era; Reviewed; Region: era; PRK00089 359786005067 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 359786005068 G1 box; other site 359786005069 GTP/Mg2+ binding site [chemical binding]; other site 359786005070 Switch I region; other site 359786005071 G2 box; other site 359786005072 Switch II region; other site 359786005073 G3 box; other site 359786005074 G4 box; other site 359786005075 G5 box; other site 359786005076 KH domain; Region: KH_2; pfam07650 359786005077 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 359786005078 active site 359786005079 catalytic motif [active] 359786005080 Zn binding site [ion binding]; other site 359786005081 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 359786005082 metal-binding heat shock protein; Provisional; Region: PRK00016 359786005083 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 359786005084 PhoH-like protein; Region: PhoH; pfam02562 359786005085 hypothetical protein; Provisional; Region: PRK13665 359786005086 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 359786005087 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 359786005088 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 359786005089 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 359786005090 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 359786005091 FeS/SAM binding site; other site 359786005092 TRAM domain; Region: TRAM; cl01282 359786005093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 359786005094 RNA methyltransferase, RsmE family; Region: TIGR00046 359786005095 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 359786005096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786005097 S-adenosylmethionine binding site [chemical binding]; other site 359786005098 chaperone protein DnaJ; Provisional; Region: PRK14280 359786005099 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 359786005100 HSP70 interaction site [polypeptide binding]; other site 359786005101 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 359786005102 substrate binding site [polypeptide binding]; other site 359786005103 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 359786005104 Zn binding sites [ion binding]; other site 359786005105 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 359786005106 dimer interface [polypeptide binding]; other site 359786005107 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 359786005108 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 359786005109 nucleotide binding site [chemical binding]; other site 359786005110 NEF interaction site [polypeptide binding]; other site 359786005111 SBD interface [polypeptide binding]; other site 359786005112 heat shock protein GrpE; Provisional; Region: PRK14140 359786005113 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 359786005114 dimer interface [polypeptide binding]; other site 359786005115 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 359786005116 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 359786005117 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 359786005118 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 359786005119 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 359786005120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 359786005121 FeS/SAM binding site; other site 359786005122 HemN C-terminal domain; Region: HemN_C; pfam06969 359786005123 GTP-binding protein LepA; Provisional; Region: PRK05433 359786005124 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 359786005125 G1 box; other site 359786005126 putative GEF interaction site [polypeptide binding]; other site 359786005127 GTP/Mg2+ binding site [chemical binding]; other site 359786005128 Switch I region; other site 359786005129 G2 box; other site 359786005130 G3 box; other site 359786005131 Switch II region; other site 359786005132 G4 box; other site 359786005133 G5 box; other site 359786005134 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 359786005135 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 359786005136 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 359786005137 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 359786005138 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 359786005139 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 359786005140 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 359786005141 Competence protein; Region: Competence; pfam03772 359786005142 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 359786005143 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 359786005144 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 359786005145 catalytic motif [active] 359786005146 Zn binding site [ion binding]; other site 359786005147 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 359786005148 Helix-hairpin-helix motif; Region: HHH; pfam00633 359786005149 Methyltransferase domain; Region: Methyltransf_31; pfam13847 359786005150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786005151 S-adenosylmethionine binding site [chemical binding]; other site 359786005152 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 359786005153 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 359786005154 Zn2+ binding site [ion binding]; other site 359786005155 Mg2+ binding site [ion binding]; other site 359786005156 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 359786005157 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 359786005158 active site 359786005159 (T/H)XGH motif; other site 359786005160 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 359786005161 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 359786005162 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 359786005163 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 359786005164 shikimate binding site; other site 359786005165 NAD(P) binding site [chemical binding]; other site 359786005166 GTPase YqeH; Provisional; Region: PRK13796 359786005167 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 359786005168 GTP/Mg2+ binding site [chemical binding]; other site 359786005169 G4 box; other site 359786005170 G5 box; other site 359786005171 G1 box; other site 359786005172 Switch I region; other site 359786005173 G2 box; other site 359786005174 G3 box; other site 359786005175 Switch II region; other site 359786005176 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 359786005177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786005178 active site 359786005179 motif I; other site 359786005180 motif II; other site 359786005181 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 359786005182 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 359786005183 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 359786005184 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 359786005185 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 359786005186 putative active site [active] 359786005187 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 359786005188 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 359786005189 ATP-grasp domain; Region: ATP-grasp_4; cl17255 359786005190 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 359786005191 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 359786005192 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 359786005193 carboxyltransferase (CT) interaction site; other site 359786005194 biotinylation site [posttranslational modification]; other site 359786005195 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 359786005196 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 359786005197 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 359786005198 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 359786005199 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 359786005200 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 359786005201 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 359786005202 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 359786005203 Sugar specificity; other site 359786005204 Pyrimidine base specificity; other site 359786005205 ATP-binding site [chemical binding]; other site 359786005206 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 359786005207 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 359786005208 Peptidase family U32; Region: Peptidase_U32; pfam01136 359786005209 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 359786005210 Peptidase family U32; Region: Peptidase_U32; pfam01136 359786005211 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 359786005212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786005213 S-adenosylmethionine binding site [chemical binding]; other site 359786005214 hypothetical protein; Provisional; Region: PRK13678 359786005215 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 359786005216 hypothetical protein; Provisional; Region: PRK05473 359786005217 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 359786005218 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 359786005219 motif 1; other site 359786005220 active site 359786005221 motif 2; other site 359786005222 motif 3; other site 359786005223 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 359786005224 DHHA1 domain; Region: DHHA1; pfam02272 359786005225 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 359786005226 AAA domain; Region: AAA_30; pfam13604 359786005227 Family description; Region: UvrD_C_2; pfam13538 359786005228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 359786005229 binding surface 359786005230 TPR motif; other site 359786005231 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 359786005232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 359786005233 binding surface 359786005234 TPR motif; other site 359786005235 TPR repeat; Region: TPR_11; pfam13414 359786005236 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 359786005237 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 359786005238 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 359786005239 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 359786005240 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 359786005241 catalytic residue [active] 359786005242 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 359786005243 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 359786005244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 359786005245 Predicted transcriptional regulator [Transcription]; Region: COG1959 359786005246 Transcriptional regulator; Region: Rrf2; pfam02082 359786005247 recombination factor protein RarA; Reviewed; Region: PRK13342 359786005248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786005249 Walker A motif; other site 359786005250 ATP binding site [chemical binding]; other site 359786005251 Walker B motif; other site 359786005252 arginine finger; other site 359786005253 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 359786005254 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 359786005255 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 359786005256 putative ATP binding site [chemical binding]; other site 359786005257 putative substrate interface [chemical binding]; other site 359786005258 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 359786005259 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 359786005260 dimer interface [polypeptide binding]; other site 359786005261 anticodon binding site; other site 359786005262 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 359786005263 homodimer interface [polypeptide binding]; other site 359786005264 motif 1; other site 359786005265 active site 359786005266 motif 2; other site 359786005267 GAD domain; Region: GAD; pfam02938 359786005268 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 359786005269 motif 3; other site 359786005270 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 359786005271 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 359786005272 dimer interface [polypeptide binding]; other site 359786005273 motif 1; other site 359786005274 active site 359786005275 motif 2; other site 359786005276 motif 3; other site 359786005277 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 359786005278 anticodon binding site; other site 359786005279 Bacterial SH3 domain homologues; Region: SH3b; smart00287 359786005280 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 359786005281 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 359786005282 active site 359786005283 metal binding site [ion binding]; metal-binding site 359786005284 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 359786005285 putative active site [active] 359786005286 dimerization interface [polypeptide binding]; other site 359786005287 putative tRNAtyr binding site [nucleotide binding]; other site 359786005288 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 359786005289 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 359786005290 Zn2+ binding site [ion binding]; other site 359786005291 Mg2+ binding site [ion binding]; other site 359786005292 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 359786005293 synthetase active site [active] 359786005294 NTP binding site [chemical binding]; other site 359786005295 metal binding site [ion binding]; metal-binding site 359786005296 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 359786005297 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 359786005298 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 359786005299 active site 359786005300 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 359786005301 DHH family; Region: DHH; pfam01368 359786005302 DHHA1 domain; Region: DHHA1; pfam02272 359786005303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 359786005304 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 359786005305 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 359786005306 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 359786005307 Protein export membrane protein; Region: SecD_SecF; pfam02355 359786005308 Preprotein translocase subunit; Region: YajC; pfam02699 359786005309 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 359786005310 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 359786005311 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 359786005312 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 359786005313 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 359786005314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786005315 Walker A motif; other site 359786005316 ATP binding site [chemical binding]; other site 359786005317 Walker B motif; other site 359786005318 arginine finger; other site 359786005319 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 359786005320 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 359786005321 RuvA N terminal domain; Region: RuvA_N; pfam01330 359786005322 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 359786005323 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 359786005324 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 359786005325 GTPase CgtA; Reviewed; Region: obgE; PRK12297 359786005326 GTP1/OBG; Region: GTP1_OBG; pfam01018 359786005327 Obg GTPase; Region: Obg; cd01898 359786005328 G1 box; other site 359786005329 GTP/Mg2+ binding site [chemical binding]; other site 359786005330 Switch I region; other site 359786005331 G2 box; other site 359786005332 G3 box; other site 359786005333 Switch II region; other site 359786005334 G4 box; other site 359786005335 G5 box; other site 359786005336 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 359786005337 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 359786005338 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 359786005339 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 359786005340 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 359786005341 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 359786005342 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 359786005343 rod shape-determining protein MreC; Region: MreC; pfam04085 359786005344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786005345 S-adenosylmethionine binding site [chemical binding]; other site 359786005346 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 359786005347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786005348 S-adenosylmethionine binding site [chemical binding]; other site 359786005349 aminoglycoside resistance protein; Provisional; Region: PRK13746 359786005350 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 359786005351 active site 359786005352 NTP binding site [chemical binding]; other site 359786005353 metal binding triad [ion binding]; metal-binding site 359786005354 antibiotic binding site [chemical binding]; other site 359786005355 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 359786005356 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 359786005357 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 359786005358 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 359786005359 Int/Topo IB signature motif; other site 359786005360 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 359786005361 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 359786005362 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 359786005363 Int/Topo IB signature motif; other site 359786005364 hypothetical protein; Reviewed; Region: PRK00024 359786005365 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 359786005366 MPN+ (JAMM) motif; other site 359786005367 Zinc-binding site [ion binding]; other site 359786005368 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 359786005369 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 359786005370 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 359786005371 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 359786005372 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 359786005373 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 359786005374 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 359786005375 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 359786005376 active site 359786005377 HIGH motif; other site 359786005378 nucleotide binding site [chemical binding]; other site 359786005379 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 359786005380 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 359786005381 active site 359786005382 KMSKS motif; other site 359786005383 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 359786005384 tRNA binding surface [nucleotide binding]; other site 359786005385 anticodon binding site; other site 359786005386 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 359786005387 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 359786005388 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 359786005389 Putative ammonia monooxygenase; Region: AmoA; pfam05145 359786005390 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 359786005391 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 359786005392 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 359786005393 inhibitor-cofactor binding pocket; inhibition site 359786005394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786005395 catalytic residue [active] 359786005396 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 359786005397 dimer interface [polypeptide binding]; other site 359786005398 active site 359786005399 Schiff base residues; other site 359786005400 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 359786005401 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 359786005402 active site 359786005403 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 359786005404 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 359786005405 domain interfaces; other site 359786005406 active site 359786005407 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 359786005408 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 359786005409 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 359786005410 tRNA; other site 359786005411 putative tRNA binding site [nucleotide binding]; other site 359786005412 putative NADP binding site [chemical binding]; other site 359786005413 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 359786005414 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 359786005415 G1 box; other site 359786005416 GTP/Mg2+ binding site [chemical binding]; other site 359786005417 Switch I region; other site 359786005418 G2 box; other site 359786005419 G3 box; other site 359786005420 Switch II region; other site 359786005421 G4 box; other site 359786005422 G5 box; other site 359786005423 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 359786005424 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 359786005425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786005426 Walker A motif; other site 359786005427 ATP binding site [chemical binding]; other site 359786005428 Walker B motif; other site 359786005429 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 359786005430 trigger factor; Provisional; Region: tig; PRK01490 359786005431 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 359786005432 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 359786005433 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 359786005434 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 359786005435 23S rRNA binding site [nucleotide binding]; other site 359786005436 L21 binding site [polypeptide binding]; other site 359786005437 L13 binding site [polypeptide binding]; other site 359786005438 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 359786005439 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 359786005440 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 359786005441 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 359786005442 lysine transporter; Provisional; Region: PRK10836 359786005443 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 359786005444 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 359786005445 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 359786005446 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 359786005447 active site 359786005448 dimer interface [polypeptide binding]; other site 359786005449 motif 1; other site 359786005450 motif 2; other site 359786005451 motif 3; other site 359786005452 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 359786005453 anticodon binding site; other site 359786005454 primosomal protein DnaI; Reviewed; Region: PRK08939 359786005455 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 359786005456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786005457 Walker A motif; other site 359786005458 ATP binding site [chemical binding]; other site 359786005459 Walker B motif; other site 359786005460 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 359786005461 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 359786005462 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 359786005463 ATP cone domain; Region: ATP-cone; pfam03477 359786005464 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 359786005465 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 359786005466 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 359786005467 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 359786005468 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 359786005469 CoA-binding site [chemical binding]; other site 359786005470 ATP-binding [chemical binding]; other site 359786005471 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 359786005472 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 359786005473 DNA binding site [nucleotide binding] 359786005474 catalytic residue [active] 359786005475 H2TH interface [polypeptide binding]; other site 359786005476 putative catalytic residues [active] 359786005477 turnover-facilitating residue; other site 359786005478 intercalation triad [nucleotide binding]; other site 359786005479 8OG recognition residue [nucleotide binding]; other site 359786005480 putative reading head residues; other site 359786005481 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 359786005482 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 359786005483 DNA polymerase I; Provisional; Region: PRK05755 359786005484 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 359786005485 active site 359786005486 metal binding site 1 [ion binding]; metal-binding site 359786005487 putative 5' ssDNA interaction site; other site 359786005488 metal binding site 3; metal-binding site 359786005489 metal binding site 2 [ion binding]; metal-binding site 359786005490 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 359786005491 putative DNA binding site [nucleotide binding]; other site 359786005492 putative metal binding site [ion binding]; other site 359786005493 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 359786005494 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 359786005495 active site 359786005496 DNA binding site [nucleotide binding] 359786005497 catalytic site [active] 359786005498 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 359786005499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 359786005500 dimer interface [polypeptide binding]; other site 359786005501 phosphorylation site [posttranslational modification] 359786005502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786005503 ATP binding site [chemical binding]; other site 359786005504 Mg2+ binding site [ion binding]; other site 359786005505 G-X-G motif; other site 359786005506 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 359786005507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786005508 active site 359786005509 phosphorylation site [posttranslational modification] 359786005510 intermolecular recognition site; other site 359786005511 dimerization interface [polypeptide binding]; other site 359786005512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 359786005513 DNA binding site [nucleotide binding] 359786005514 isocitrate dehydrogenase; Reviewed; Region: PRK07006 359786005515 isocitrate dehydrogenase; Validated; Region: PRK07362 359786005516 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 359786005517 dimer interface [polypeptide binding]; other site 359786005518 Citrate synthase; Region: Citrate_synt; pfam00285 359786005519 active site 359786005520 citrylCoA binding site [chemical binding]; other site 359786005521 oxalacetate/citrate binding site [chemical binding]; other site 359786005522 coenzyme A binding site [chemical binding]; other site 359786005523 catalytic triad [active] 359786005524 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 359786005525 pyruvate kinase; Provisional; Region: PRK06354 359786005526 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 359786005527 domain interfaces; other site 359786005528 active site 359786005529 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 359786005530 6-phosphofructokinase; Provisional; Region: PRK03202 359786005531 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 359786005532 active site 359786005533 ADP/pyrophosphate binding site [chemical binding]; other site 359786005534 dimerization interface [polypeptide binding]; other site 359786005535 allosteric effector site; other site 359786005536 fructose-1,6-bisphosphate binding site; other site 359786005537 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 359786005538 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 359786005539 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 359786005540 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 359786005541 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 359786005542 Malic enzyme, N-terminal domain; Region: malic; pfam00390 359786005543 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 359786005544 putative NAD(P) binding site [chemical binding]; other site 359786005545 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 359786005546 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 359786005547 active site 359786005548 PHP Thumb interface [polypeptide binding]; other site 359786005549 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 359786005550 generic binding surface I; other site 359786005551 generic binding surface II; other site 359786005552 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 359786005553 DHH family; Region: DHH; pfam01368 359786005554 DHHA1 domain; Region: DHHA1; pfam02272 359786005555 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 359786005556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 359786005557 DNA-binding site [nucleotide binding]; DNA binding site 359786005558 DRTGG domain; Region: DRTGG; pfam07085 359786005559 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 359786005560 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 359786005561 active site 2 [active] 359786005562 active site 1 [active] 359786005563 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 359786005564 Ligand Binding Site [chemical binding]; other site 359786005565 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 359786005566 metal-dependent hydrolase; Provisional; Region: PRK00685 359786005567 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 359786005568 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 359786005569 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 359786005570 active site 359786005571 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 359786005572 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 359786005573 hexamer interface [polypeptide binding]; other site 359786005574 ligand binding site [chemical binding]; other site 359786005575 putative active site [active] 359786005576 NAD(P) binding site [chemical binding]; other site 359786005577 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 359786005578 Ligand Binding Site [chemical binding]; other site 359786005579 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 359786005580 propionate/acetate kinase; Provisional; Region: PRK12379 359786005581 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 359786005582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786005583 S-adenosylmethionine binding site [chemical binding]; other site 359786005584 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 359786005585 dimer interface [polypeptide binding]; other site 359786005586 catalytic triad [active] 359786005587 peroxidatic and resolving cysteines [active] 359786005588 hypothetical protein; Provisional; Region: PRK10621 359786005589 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 359786005590 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 359786005591 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 359786005592 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 359786005593 Ligand Binding Site [chemical binding]; other site 359786005594 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 359786005595 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 359786005596 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 359786005597 catalytic residue [active] 359786005598 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 359786005599 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 359786005600 GAF domain; Region: GAF_2; pfam13185 359786005601 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 359786005602 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 359786005603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 359786005604 RNA binding surface [nucleotide binding]; other site 359786005605 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 359786005606 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 359786005607 active site 359786005608 catalytic site [active] 359786005609 OsmC-like protein; Region: OsmC; cl00767 359786005610 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 359786005611 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 359786005612 catalytic residue [active] 359786005613 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 359786005614 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 359786005615 ligand binding site [chemical binding]; other site 359786005616 NAD binding site [chemical binding]; other site 359786005617 dimerization interface [polypeptide binding]; other site 359786005618 catalytic site [active] 359786005619 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 359786005620 putative L-serine binding site [chemical binding]; other site 359786005621 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 359786005622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786005623 motif II; other site 359786005624 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 359786005625 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 359786005626 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 359786005627 active site turn [active] 359786005628 phosphorylation site [posttranslational modification] 359786005629 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 359786005630 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 359786005631 putative acyl-acceptor binding pocket; other site 359786005632 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 359786005633 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 359786005634 protein binding site [polypeptide binding]; other site 359786005635 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 359786005636 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 359786005637 active site 359786005638 HIGH motif; other site 359786005639 dimer interface [polypeptide binding]; other site 359786005640 KMSKS motif; other site 359786005641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 359786005642 RNA binding surface [nucleotide binding]; other site 359786005643 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 359786005644 Transglycosylase; Region: Transgly; pfam00912 359786005645 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 359786005646 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 359786005647 NEAr Transporter domain; Region: NEAT; smart00725 359786005648 NEAr Transporter domain; Region: NEAT; smart00725 359786005649 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 359786005650 heme-binding site [chemical binding]; other site 359786005651 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 359786005652 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 359786005653 Potassium binding sites [ion binding]; other site 359786005654 Cesium cation binding sites [ion binding]; other site 359786005655 acetyl-CoA synthetase; Provisional; Region: PRK04319 359786005656 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 359786005657 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 359786005658 active site 359786005659 acyl-activating enzyme (AAE) consensus motif; other site 359786005660 putative CoA binding site [chemical binding]; other site 359786005661 AMP binding site [chemical binding]; other site 359786005662 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 359786005663 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 359786005664 active site 359786005665 Zn binding site [ion binding]; other site 359786005666 catabolite control protein A; Region: ccpA; TIGR01481 359786005667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 359786005668 DNA binding site [nucleotide binding] 359786005669 domain linker motif; other site 359786005670 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 359786005671 dimerization interface [polypeptide binding]; other site 359786005672 effector binding site; other site 359786005673 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 359786005674 Chorismate mutase type II; Region: CM_2; cl00693 359786005675 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 359786005676 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 359786005677 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 359786005678 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 359786005679 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 359786005680 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 359786005681 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 359786005682 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 359786005683 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 359786005684 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 359786005685 putative tRNA-binding site [nucleotide binding]; other site 359786005686 hypothetical protein; Provisional; Region: PRK13668 359786005687 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 359786005688 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 359786005689 catalytic residues [active] 359786005690 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 359786005691 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 359786005692 oligomer interface [polypeptide binding]; other site 359786005693 active site 359786005694 metal binding site [ion binding]; metal-binding site 359786005695 Predicted small secreted protein [Function unknown]; Region: COG5584 359786005696 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 359786005697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786005698 S-adenosylmethionine binding site [chemical binding]; other site 359786005699 Phosphotransferase enzyme family; Region: APH; pfam01636 359786005700 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 359786005701 active site 359786005702 substrate binding site [chemical binding]; other site 359786005703 ATP binding site [chemical binding]; other site 359786005704 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 359786005705 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 359786005706 homodimer interface [polypeptide binding]; other site 359786005707 substrate-cofactor binding pocket; other site 359786005708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786005709 catalytic residue [active] 359786005710 dipeptidase PepV; Reviewed; Region: PRK07318 359786005711 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 359786005712 active site 359786005713 metal binding site [ion binding]; metal-binding site 359786005714 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 359786005715 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 359786005716 RNA binding surface [nucleotide binding]; other site 359786005717 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 359786005718 active site 359786005719 uracil binding [chemical binding]; other site 359786005720 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 359786005721 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 359786005722 HI0933-like protein; Region: HI0933_like; pfam03486 359786005723 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786005724 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 359786005725 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005726 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005727 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005728 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005729 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005730 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005731 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005732 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005733 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005734 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005735 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005736 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005737 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005738 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005739 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786005740 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 359786005741 active site residue [active] 359786005742 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 359786005743 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 359786005744 HIGH motif; other site 359786005745 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 359786005746 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 359786005747 active site 359786005748 KMSKS motif; other site 359786005749 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 359786005750 tRNA binding surface [nucleotide binding]; other site 359786005751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786005752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 359786005753 putative substrate translocation pore; other site 359786005754 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 359786005755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786005756 S-adenosylmethionine binding site [chemical binding]; other site 359786005757 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786005758 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 359786005759 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 359786005760 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 359786005761 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 359786005762 homopentamer interface [polypeptide binding]; other site 359786005763 active site 359786005764 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 359786005765 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 359786005766 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 359786005767 dimerization interface [polypeptide binding]; other site 359786005768 active site 359786005769 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 359786005770 Lumazine binding domain; Region: Lum_binding; pfam00677 359786005771 Lumazine binding domain; Region: Lum_binding; pfam00677 359786005772 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 359786005773 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 359786005774 catalytic motif [active] 359786005775 Zn binding site [ion binding]; other site 359786005776 RibD C-terminal domain; Region: RibD_C; cl17279 359786005777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 359786005778 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 359786005779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 359786005780 dimerization interface [polypeptide binding]; other site 359786005781 putative DNA binding site [nucleotide binding]; other site 359786005782 putative Zn2+ binding site [ion binding]; other site 359786005783 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 359786005784 arsenical pump membrane protein; Provisional; Region: PRK15445 359786005785 transmembrane helices; other site 359786005786 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 359786005787 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 359786005788 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 359786005789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 359786005790 DNA binding residues [nucleotide binding] 359786005791 CAAX protease self-immunity; Region: Abi; pfam02517 359786005792 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 359786005793 active site 359786005794 intersubunit interactions; other site 359786005795 catalytic residue [active] 359786005796 camphor resistance protein CrcB; Provisional; Region: PRK14201 359786005797 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 359786005798 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 359786005799 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 359786005800 active site 359786005801 catalytic tetrad [active] 359786005802 S-adenosylmethionine synthetase; Validated; Region: PRK05250 359786005803 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 359786005804 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 359786005805 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 359786005806 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 359786005807 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 359786005808 active site 359786005809 substrate-binding site [chemical binding]; other site 359786005810 metal-binding site [ion binding] 359786005811 ATP binding site [chemical binding]; other site 359786005812 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 359786005813 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 359786005814 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 359786005815 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 359786005816 nudix motif; other site 359786005817 Haemolytic domain; Region: Haemolytic; pfam01809 359786005818 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 359786005819 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 359786005820 metal binding site [ion binding]; metal-binding site 359786005821 substrate binding pocket [chemical binding]; other site 359786005822 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 359786005823 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 359786005824 acyl-activating enzyme (AAE) consensus motif; other site 359786005825 putative AMP binding site [chemical binding]; other site 359786005826 putative active site [active] 359786005827 putative CoA binding site [chemical binding]; other site 359786005828 Excalibur calcium-binding domain; Region: Excalibur; smart00894 359786005829 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 359786005830 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 359786005831 Integrase core domain; Region: rve; pfam00665 359786005832 DDE domain; Region: DDE_Tnp_IS240; pfam13610 359786005833 Integrase core domain; Region: rve_3; pfam13683 359786005834 putative transposase OrfB; Reviewed; Region: PHA02517 359786005835 Transposase; Region: HTH_Tnp_1; cl17663 359786005836 Winged helix-turn helix; Region: HTH_29; pfam13551 359786005837 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 359786005838 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 359786005839 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 359786005840 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 359786005841 HsdM N-terminal domain; Region: HsdM_N; pfam12161 359786005842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786005843 S-adenosylmethionine binding site [chemical binding]; other site 359786005844 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 359786005845 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 359786005846 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 359786005847 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 359786005848 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 359786005849 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 359786005850 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 359786005851 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 359786005852 beta-channel forming cytolysin; Region: hlyII; TIGR01002 359786005853 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 359786005854 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 359786005855 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 359786005856 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 359786005857 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 359786005858 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 359786005859 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786005860 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 359786005861 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786005862 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 359786005863 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786005864 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 359786005865 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786005866 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 359786005867 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 359786005868 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 359786005869 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 359786005870 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 359786005871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 359786005872 ferrochelatase; Provisional; Region: PRK12435 359786005873 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 359786005874 C-terminal domain interface [polypeptide binding]; other site 359786005875 active site 359786005876 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 359786005877 active site 359786005878 N-terminal domain interface [polypeptide binding]; other site 359786005879 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 359786005880 substrate binding site [chemical binding]; other site 359786005881 active site 359786005882 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 359786005883 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 359786005884 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 359786005885 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 359786005886 Walker A/P-loop; other site 359786005887 ATP binding site [chemical binding]; other site 359786005888 Q-loop/lid; other site 359786005889 ABC transporter signature motif; other site 359786005890 Walker B; other site 359786005891 D-loop; other site 359786005892 H-loop/switch region; other site 359786005893 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 359786005894 HIT family signature motif; other site 359786005895 catalytic residue [active] 359786005896 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 359786005897 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 359786005898 SurA N-terminal domain; Region: SurA_N_3; cl07813 359786005899 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 359786005900 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 359786005901 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 359786005902 generic binding surface II; other site 359786005903 generic binding surface I; other site 359786005904 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 359786005905 Zn2+ binding site [ion binding]; other site 359786005906 Mg2+ binding site [ion binding]; other site 359786005907 Uncharacterized conserved protein [Function unknown]; Region: COG4717 359786005908 P-loop containing region of AAA domain; Region: AAA_29; cl17516 359786005909 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 359786005910 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 359786005911 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 359786005912 active site 359786005913 metal binding site [ion binding]; metal-binding site 359786005914 DNA binding site [nucleotide binding] 359786005915 hypothetical protein; Provisional; Region: PRK13676 359786005916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 359786005917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 359786005918 Transposase; Region: DDE_Tnp_ISL3; pfam01610 359786005919 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 359786005920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786005921 non-specific DNA binding site [nucleotide binding]; other site 359786005922 salt bridge; other site 359786005923 sequence-specific DNA binding site [nucleotide binding]; other site 359786005924 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 359786005925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786005926 active site 359786005927 phosphorylation site [posttranslational modification] 359786005928 intermolecular recognition site; other site 359786005929 dimerization interface [polypeptide binding]; other site 359786005930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 359786005931 DNA binding residues [nucleotide binding] 359786005932 dimerization interface [polypeptide binding]; other site 359786005933 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 359786005934 GAF domain; Region: GAF_3; pfam13492 359786005935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 359786005936 Histidine kinase; Region: HisKA_3; pfam07730 359786005937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786005938 ATP binding site [chemical binding]; other site 359786005939 Mg2+ binding site [ion binding]; other site 359786005940 G-X-G motif; other site 359786005941 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 359786005942 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 359786005943 active site 359786005944 fumarate hydratase; Reviewed; Region: fumC; PRK00485 359786005945 Class II fumarases; Region: Fumarase_classII; cd01362 359786005946 active site 359786005947 tetramer interface [polypeptide binding]; other site 359786005948 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 359786005949 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 359786005950 active site 359786005951 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 359786005952 epoxyqueuosine reductase; Region: TIGR00276 359786005953 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 359786005954 HEAT repeats; Region: HEAT_2; pfam13646 359786005955 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 359786005956 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 359786005957 Walker A/P-loop; other site 359786005958 ATP binding site [chemical binding]; other site 359786005959 Q-loop/lid; other site 359786005960 ABC transporter signature motif; other site 359786005961 Walker B; other site 359786005962 D-loop; other site 359786005963 H-loop/switch region; other site 359786005964 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 359786005965 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 359786005966 substrate binding pocket [chemical binding]; other site 359786005967 membrane-bound complex binding site; other site 359786005968 hinge residues; other site 359786005969 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 359786005970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786005971 dimer interface [polypeptide binding]; other site 359786005972 conserved gate region; other site 359786005973 putative PBP binding loops; other site 359786005974 ABC-ATPase subunit interface; other site 359786005975 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 359786005976 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 359786005977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 359786005978 Transposase; Region: DDE_Tnp_ISL3; pfam01610 359786005979 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 359786005980 metal binding site 2 [ion binding]; metal-binding site 359786005981 putative DNA binding helix; other site 359786005982 metal binding site 1 [ion binding]; metal-binding site 359786005983 dimer interface [polypeptide binding]; other site 359786005984 structural Zn2+ binding site [ion binding]; other site 359786005985 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 359786005986 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 359786005987 putative ligand binding site [chemical binding]; other site 359786005988 NAD binding site [chemical binding]; other site 359786005989 catalytic site [active] 359786005990 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 359786005991 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 359786005992 catalytic triad [active] 359786005993 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 359786005994 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 359786005995 inhibitor-cofactor binding pocket; inhibition site 359786005996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786005997 catalytic residue [active] 359786005998 Predicted membrane protein [Function unknown]; Region: COG4129 359786005999 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 359786006000 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 359786006001 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 359786006002 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 359786006003 Walker A/P-loop; other site 359786006004 ATP binding site [chemical binding]; other site 359786006005 Q-loop/lid; other site 359786006006 ABC transporter signature motif; other site 359786006007 Walker B; other site 359786006008 D-loop; other site 359786006009 H-loop/switch region; other site 359786006010 hypothetical protein; Provisional; Region: PRK13662 359786006011 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 359786006012 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 359786006013 minor groove reading motif; other site 359786006014 helix-hairpin-helix signature motif; other site 359786006015 substrate binding pocket [chemical binding]; other site 359786006016 active site 359786006017 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 359786006018 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 359786006019 DNA binding and oxoG recognition site [nucleotide binding] 359786006020 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 359786006021 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 359786006022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786006023 Walker A/P-loop; other site 359786006024 ATP binding site [chemical binding]; other site 359786006025 Q-loop/lid; other site 359786006026 ABC transporter signature motif; other site 359786006027 Walker B; other site 359786006028 H-loop/switch region; other site 359786006029 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 359786006030 recombination regulator RecX; Provisional; Region: recX; PRK14135 359786006031 glycosyltransferase; Provisional; Region: PRK13481 359786006032 Transglycosylase; Region: Transgly; pfam00912 359786006033 intracellular protease, PfpI family; Region: PfpI; TIGR01382 359786006034 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 359786006035 proposed catalytic triad [active] 359786006036 conserved cys residue [active] 359786006037 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 359786006038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 359786006039 FeS/SAM binding site; other site 359786006040 YfkB-like domain; Region: YfkB; pfam08756 359786006041 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 359786006042 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 359786006043 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 359786006044 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 359786006045 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 359786006046 Low molecular weight phosphatase family; Region: LMWPc; cd00115 359786006047 active site 359786006048 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 359786006049 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 359786006050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786006051 active site 359786006052 phosphorylation site [posttranslational modification] 359786006053 intermolecular recognition site; other site 359786006054 dimerization interface [polypeptide binding]; other site 359786006055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 359786006056 DNA binding residues [nucleotide binding] 359786006057 dimerization interface [polypeptide binding]; other site 359786006058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 359786006059 Histidine kinase; Region: HisKA_3; pfam07730 359786006060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786006061 ATP binding site [chemical binding]; other site 359786006062 Mg2+ binding site [ion binding]; other site 359786006063 G-X-G motif; other site 359786006064 Predicted membrane protein [Function unknown]; Region: COG4758 359786006065 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 359786006066 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 359786006067 active site 359786006068 Predicted membrane protein [Function unknown]; Region: COG4129 359786006069 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 359786006070 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 359786006071 catalytic triad [active] 359786006072 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 359786006073 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 359786006074 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 359786006075 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 359786006076 Ferritin-like domain; Region: Ferritin; pfam00210 359786006077 ferroxidase diiron center [ion binding]; other site 359786006078 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 359786006079 active site 359786006080 catalytic site [active] 359786006081 substrate binding site [chemical binding]; other site 359786006082 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 359786006083 active site 359786006084 DNA polymerase IV; Validated; Region: PRK02406 359786006085 DNA binding site [nucleotide binding] 359786006086 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 359786006087 TRAM domain; Region: TRAM; cl01282 359786006088 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 359786006089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786006090 S-adenosylmethionine binding site [chemical binding]; other site 359786006091 putative lipid kinase; Reviewed; Region: PRK13337 359786006092 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 359786006093 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 359786006094 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 359786006095 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 359786006096 GatB domain; Region: GatB_Yqey; pfam02637 359786006097 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 359786006098 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 359786006099 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 359786006100 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 359786006101 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 359786006102 Na binding site [ion binding]; other site 359786006103 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 359786006104 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 359786006105 putative dimer interface [polypeptide binding]; other site 359786006106 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 359786006107 putative dimer interface [polypeptide binding]; other site 359786006108 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 359786006109 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 359786006110 nucleotide binding pocket [chemical binding]; other site 359786006111 K-X-D-G motif; other site 359786006112 catalytic site [active] 359786006113 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 359786006114 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 359786006115 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 359786006116 Dimer interface [polypeptide binding]; other site 359786006117 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 359786006118 Part of AAA domain; Region: AAA_19; pfam13245 359786006119 Family description; Region: UvrD_C_2; pfam13538 359786006120 PcrB family; Region: PcrB; pfam01884 359786006121 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 359786006122 substrate binding site [chemical binding]; other site 359786006123 putative active site [active] 359786006124 dimer interface [polypeptide binding]; other site 359786006125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 359786006126 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 359786006127 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 359786006128 tetramer interface [polypeptide binding]; other site 359786006129 active site 359786006130 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 359786006131 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 359786006132 Staphostatin A; Region: Staphostatin_A; pfam09022 359786006133 NETI protein; Region: NETI; pfam14044 359786006134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 359786006135 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 359786006136 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 359786006137 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 359786006138 homodimer interface [polypeptide binding]; other site 359786006139 NAD binding pocket [chemical binding]; other site 359786006140 ATP binding pocket [chemical binding]; other site 359786006141 Mg binding site [ion binding]; other site 359786006142 active-site loop [active] 359786006143 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 359786006144 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 359786006145 active site 359786006146 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 359786006147 active site 359786006148 dimer interface [polypeptide binding]; other site 359786006149 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 359786006150 Prephenate dehydratase; Region: PDT; pfam00800 359786006151 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 359786006152 putative L-Phe binding site [chemical binding]; other site 359786006153 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 359786006154 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 359786006155 transmembrane helices; other site 359786006156 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 359786006157 Isochorismatase family; Region: Isochorismatase; pfam00857 359786006158 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 359786006159 catalytic triad [active] 359786006160 conserved cis-peptide bond; other site 359786006161 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 359786006162 DHH family; Region: DHH; pfam01368 359786006163 DHHA2 domain; Region: DHHA2; pfam02833 359786006164 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 359786006165 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 359786006166 NAD(P) binding site [chemical binding]; other site 359786006167 catalytic residues [active] 359786006168 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 359786006169 YolD-like protein; Region: YolD; pfam08863 359786006170 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 359786006171 active site 359786006172 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 359786006173 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 359786006174 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 359786006175 Bacterial PH domain; Region: DUF304; cl01348 359786006176 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 359786006177 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 359786006178 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 359786006179 Walker A/P-loop; other site 359786006180 ATP binding site [chemical binding]; other site 359786006181 Q-loop/lid; other site 359786006182 ABC transporter signature motif; other site 359786006183 Walker B; other site 359786006184 D-loop; other site 359786006185 H-loop/switch region; other site 359786006186 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 359786006187 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 359786006188 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 359786006189 Walker A/P-loop; other site 359786006190 ATP binding site [chemical binding]; other site 359786006191 Q-loop/lid; other site 359786006192 ABC transporter signature motif; other site 359786006193 Walker B; other site 359786006194 D-loop; other site 359786006195 H-loop/switch region; other site 359786006196 Predicted transcriptional regulators [Transcription]; Region: COG1725 359786006197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 359786006198 DNA-binding site [nucleotide binding]; DNA binding site 359786006199 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 359786006200 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 359786006201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786006202 homodimer interface [polypeptide binding]; other site 359786006203 catalytic residue [active] 359786006204 MAP domain; Region: MAP; pfam03642 359786006205 MAP domain; Region: MAP; pfam03642 359786006206 MAP domain; Region: MAP; pfam03642 359786006207 MAP domain; Region: MAP; pfam03642 359786006208 MAP domain; Region: MAP; pfam03642 359786006209 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 359786006210 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 359786006211 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 359786006212 Bacterial SH3 domain homologues; Region: SH3b; smart00287 359786006213 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 359786006214 CHAP domain; Region: CHAP; pfam05257 359786006215 Small integral membrane protein [Function unknown]; Region: COG5546 359786006216 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 359786006217 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 359786006218 TolA protein; Region: tolA_full; TIGR02794 359786006219 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 359786006220 Phage tail protein; Region: Sipho_tail; cl17486 359786006221 Phage tail protein; Region: Sipho_tail; cl17486 359786006222 Phage-related minor tail protein [Function unknown]; Region: COG5280 359786006223 Phage-related protein [Function unknown]; Region: COG5412 359786006224 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 359786006225 Peptidase family M23; Region: Peptidase_M23; pfam01551 359786006226 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 359786006227 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 359786006228 N-acetyl-D-glucosamine binding site [chemical binding]; other site 359786006229 catalytic residue [active] 359786006230 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 359786006231 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 359786006232 Phage capsid family; Region: Phage_capsid; pfam05065 359786006233 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 359786006234 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 359786006235 oligomer interface [polypeptide binding]; other site 359786006236 active site residues [active] 359786006237 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 359786006238 Phage-related protein [Function unknown]; Region: COG4695; cl01923 359786006239 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 359786006240 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 359786006241 HNH endonuclease; Region: HNH; pfam01844 359786006242 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 359786006243 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 359786006244 Transcriptional activator RinB; Region: RinB; pfam06116 359786006245 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 359786006246 dUTPase; Region: dUTPase_2; pfam08761 359786006247 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 359786006248 active site 359786006249 homodimer interface [polypeptide binding]; other site 359786006250 metal binding site [ion binding]; metal-binding site 359786006251 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 359786006252 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 359786006253 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 359786006254 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 359786006255 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 359786006256 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 359786006257 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 359786006258 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 359786006259 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 359786006260 dimer interface [polypeptide binding]; other site 359786006261 ssDNA binding site [nucleotide binding]; other site 359786006262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 359786006263 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 359786006264 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 359786006265 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 359786006266 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 359786006267 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 359786006268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 359786006269 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 359786006270 AntA/AntB antirepressor; Region: AntA; cl01430 359786006271 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 359786006272 Protein of unknown function (DUF739); Region: DUF739; pfam05339 359786006273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786006274 non-specific DNA binding site [nucleotide binding]; other site 359786006275 salt bridge; other site 359786006276 sequence-specific DNA binding site [nucleotide binding]; other site 359786006277 Predicted transcriptional regulator [Transcription]; Region: COG2932 359786006278 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 359786006279 Catalytic site [active] 359786006280 HIRAN domain; Region: HIRAN; pfam08797 359786006281 PemK-like protein; Region: PemK; pfam02452 359786006282 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 359786006283 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 359786006284 Int/Topo IB signature motif; other site 359786006285 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 359786006286 putative catalytic site [active] 359786006287 phosphate binding site [ion binding]; other site 359786006288 metal binding site A [ion binding]; metal-binding site 359786006289 metal binding site C [ion binding]; metal-binding site 359786006290 metal binding site B [ion binding]; metal-binding site 359786006291 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 359786006292 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 359786006293 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 359786006294 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 359786006295 metal binding site [ion binding]; metal-binding site 359786006296 dimer interface [polypeptide binding]; other site 359786006297 Cation transport protein; Region: TrkH; cl17365 359786006298 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 359786006299 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 359786006300 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 359786006301 ring oligomerisation interface [polypeptide binding]; other site 359786006302 ATP/Mg binding site [chemical binding]; other site 359786006303 stacking interactions; other site 359786006304 hinge regions; other site 359786006305 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 359786006306 oligomerisation interface [polypeptide binding]; other site 359786006307 mobile loop; other site 359786006308 roof hairpin; other site 359786006309 CAAX protease self-immunity; Region: Abi; pfam02517 359786006310 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 359786006311 dimer interface [polypeptide binding]; other site 359786006312 FMN binding site [chemical binding]; other site 359786006313 Predicted amidohydrolase [General function prediction only]; Region: COG0388 359786006314 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 359786006315 putative active site [active] 359786006316 catalytic triad [active] 359786006317 putative dimer interface [polypeptide binding]; other site 359786006318 delta-hemolysin; Provisional; Region: PRK14752 359786006319 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription]; Region: AgrB; COG4512 359786006320 Staphylococcal AgrD protein; Region: AgrD; pfam05931 359786006321 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 359786006322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786006323 active site 359786006324 phosphorylation site [posttranslational modification] 359786006325 intermolecular recognition site; other site 359786006326 dimerization interface [polypeptide binding]; other site 359786006327 LytTr DNA-binding domain; Region: LytTR; pfam04397 359786006328 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 359786006329 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 359786006330 putative substrate binding site [chemical binding]; other site 359786006331 putative ATP binding site [chemical binding]; other site 359786006332 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 359786006333 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 359786006334 substrate binding [chemical binding]; other site 359786006335 active site 359786006336 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 359786006337 Transcriptional regulators [Transcription]; Region: PurR; COG1609 359786006338 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 359786006339 DNA binding site [nucleotide binding] 359786006340 domain linker motif; other site 359786006341 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 359786006342 dimerization interface [polypeptide binding]; other site 359786006343 ligand binding site [chemical binding]; other site 359786006344 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 359786006345 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 359786006346 CPxP motif; other site 359786006347 Predicted transporter component [General function prediction only]; Region: COG2391 359786006348 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 359786006349 Sulphur transport; Region: Sulf_transp; pfam04143 359786006350 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 359786006351 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 359786006352 CoA binding domain; Region: CoA_binding; pfam02629 359786006353 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 359786006354 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 359786006355 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 359786006356 ABC transporter; Region: ABC_tran_2; pfam12848 359786006357 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 359786006358 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 359786006359 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 359786006360 Walker A/P-loop; other site 359786006361 ATP binding site [chemical binding]; other site 359786006362 Q-loop/lid; other site 359786006363 ABC transporter signature motif; other site 359786006364 Walker B; other site 359786006365 D-loop; other site 359786006366 H-loop/switch region; other site 359786006367 UGMP family protein; Validated; Region: PRK09604 359786006368 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 359786006369 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 359786006370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786006371 Coenzyme A binding pocket [chemical binding]; other site 359786006372 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 359786006373 Glycoprotease family; Region: Peptidase_M22; pfam00814 359786006374 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 359786006375 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 359786006376 6-phosphogluconate dehydratase; Region: edd; TIGR01196 359786006377 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 359786006378 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 359786006379 PYR/PP interface [polypeptide binding]; other site 359786006380 dimer interface [polypeptide binding]; other site 359786006381 TPP binding site [chemical binding]; other site 359786006382 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 359786006383 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 359786006384 TPP-binding site [chemical binding]; other site 359786006385 dimer interface [polypeptide binding]; other site 359786006386 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 359786006387 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 359786006388 ketol-acid reductoisomerase; Provisional; Region: PRK05479 359786006389 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 359786006390 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 359786006391 2-isopropylmalate synthase; Validated; Region: PRK00915 359786006392 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 359786006393 active site 359786006394 catalytic residues [active] 359786006395 metal binding site [ion binding]; metal-binding site 359786006396 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 359786006397 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 359786006398 tartrate dehydrogenase; Region: TTC; TIGR02089 359786006399 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 359786006400 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 359786006401 substrate binding site [chemical binding]; other site 359786006402 ligand binding site [chemical binding]; other site 359786006403 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 359786006404 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 359786006405 substrate binding site [chemical binding]; other site 359786006406 threonine dehydratase; Validated; Region: PRK08639 359786006407 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 359786006408 tetramer interface [polypeptide binding]; other site 359786006409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786006410 catalytic residue [active] 359786006411 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 359786006412 putative Ile/Val binding site [chemical binding]; other site 359786006413 5S ribosomal RNA region; weak similarity to 5S 359786006414 5S ribosomal RNA region; similarity to 5S 359786006415 5S ribosomal RNA region; weak similarity to 5S 359786006416 hypothetical protein; Provisional; Region: PRK04351 359786006417 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 359786006418 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 359786006419 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 359786006420 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 359786006421 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 359786006422 RNA binding site [nucleotide binding]; other site 359786006423 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 359786006424 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 359786006425 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 359786006426 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 359786006427 DNA binding residues [nucleotide binding] 359786006428 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 359786006429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786006430 ATP binding site [chemical binding]; other site 359786006431 Mg2+ binding site [ion binding]; other site 359786006432 G-X-G motif; other site 359786006433 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 359786006434 anti sigma factor interaction site; other site 359786006435 regulatory phosphorylation site [posttranslational modification]; other site 359786006436 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 359786006437 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 359786006438 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 359786006439 PemK-like protein; Region: PemK; pfam02452 359786006440 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 359786006441 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 359786006442 active site 359786006443 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 359786006444 dimer interface [polypeptide binding]; other site 359786006445 substrate binding site [chemical binding]; other site 359786006446 catalytic residues [active] 359786006447 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 359786006448 Uncharacterized conserved protein [Function unknown]; Region: COG3402 359786006449 Predicted membrane protein [Function unknown]; Region: COG3428 359786006450 Bacterial PH domain; Region: DUF304; pfam03703 359786006451 Bacterial PH domain; Region: DUF304; pfam03703 359786006452 Bacterial PH domain; Region: DUF304; cl01348 359786006453 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 359786006454 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 359786006455 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 359786006456 Soluble P-type ATPase [General function prediction only]; Region: COG4087 359786006457 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 359786006458 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 359786006459 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 359786006460 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 359786006461 Ligand Binding Site [chemical binding]; other site 359786006462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 359786006463 dimer interface [polypeptide binding]; other site 359786006464 phosphorylation site [posttranslational modification] 359786006465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786006466 ATP binding site [chemical binding]; other site 359786006467 Mg2+ binding site [ion binding]; other site 359786006468 G-X-G motif; other site 359786006469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 359786006470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786006471 active site 359786006472 phosphorylation site [posttranslational modification] 359786006473 intermolecular recognition site; other site 359786006474 dimerization interface [polypeptide binding]; other site 359786006475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 359786006476 DNA binding site [nucleotide binding] 359786006477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 359786006478 Transposase; Region: DDE_Tnp_ISL3; pfam01610 359786006479 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 359786006480 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 359786006481 ATP binding site [chemical binding]; other site 359786006482 Mg++ binding site [ion binding]; other site 359786006483 motif III; other site 359786006484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 359786006485 nucleotide binding region [chemical binding]; other site 359786006486 ATP-binding site [chemical binding]; other site 359786006487 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 359786006488 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 359786006489 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 359786006490 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 359786006491 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 359786006492 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 359786006493 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 359786006494 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 359786006495 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 359786006496 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 359786006497 putative homodimer interface [polypeptide binding]; other site 359786006498 putative homotetramer interface [polypeptide binding]; other site 359786006499 allosteric switch controlling residues; other site 359786006500 putative metal binding site [ion binding]; other site 359786006501 putative homodimer-homodimer interface [polypeptide binding]; other site 359786006502 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 359786006503 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 359786006504 putative active site [active] 359786006505 catalytic site [active] 359786006506 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 359786006507 putative active site [active] 359786006508 catalytic site [active] 359786006509 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 359786006510 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 359786006511 Zn2+ binding site [ion binding]; other site 359786006512 Mg2+ binding site [ion binding]; other site 359786006513 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 359786006514 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 359786006515 thiamine phosphate binding site [chemical binding]; other site 359786006516 active site 359786006517 pyrophosphate binding site [ion binding]; other site 359786006518 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 359786006519 substrate binding site [chemical binding]; other site 359786006520 multimerization interface [polypeptide binding]; other site 359786006521 ATP binding site [chemical binding]; other site 359786006522 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 359786006523 dimer interface [polypeptide binding]; other site 359786006524 substrate binding site [chemical binding]; other site 359786006525 ATP binding site [chemical binding]; other site 359786006526 thiaminase II; Region: salvage_TenA; TIGR04306 359786006527 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 359786006528 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 359786006529 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 359786006530 dimer interface [polypeptide binding]; other site 359786006531 ssDNA binding site [nucleotide binding]; other site 359786006532 tetramer (dimer of dimers) interface [polypeptide binding]; other site 359786006533 YwpF-like protein; Region: YwpF; pfam14183 359786006534 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 359786006535 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 359786006536 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 359786006537 hinge; other site 359786006538 active site 359786006539 Predicted membrane protein [Function unknown]; Region: COG4836 359786006540 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 359786006541 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 359786006542 gamma subunit interface [polypeptide binding]; other site 359786006543 epsilon subunit interface [polypeptide binding]; other site 359786006544 LBP interface [polypeptide binding]; other site 359786006545 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 359786006546 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 359786006547 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 359786006548 alpha subunit interaction interface [polypeptide binding]; other site 359786006549 Walker A motif; other site 359786006550 ATP binding site [chemical binding]; other site 359786006551 Walker B motif; other site 359786006552 inhibitor binding site; inhibition site 359786006553 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 359786006554 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 359786006555 core domain interface [polypeptide binding]; other site 359786006556 delta subunit interface [polypeptide binding]; other site 359786006557 epsilon subunit interface [polypeptide binding]; other site 359786006558 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 359786006559 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 359786006560 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 359786006561 beta subunit interaction interface [polypeptide binding]; other site 359786006562 Walker A motif; other site 359786006563 ATP binding site [chemical binding]; other site 359786006564 Walker B motif; other site 359786006565 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 359786006566 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 359786006567 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 359786006568 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 359786006569 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 359786006570 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 359786006571 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 359786006572 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 359786006573 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 359786006574 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 359786006575 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 359786006576 active site 359786006577 homodimer interface [polypeptide binding]; other site 359786006578 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 359786006579 active site 359786006580 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 359786006581 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 359786006582 dimer interface [polypeptide binding]; other site 359786006583 active site 359786006584 glycine-pyridoxal phosphate binding site [chemical binding]; other site 359786006585 folate binding site [chemical binding]; other site 359786006586 hypothetical protein; Provisional; Region: PRK13690 359786006587 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 359786006588 Low molecular weight phosphatase family; Region: LMWPc; cd00115 359786006589 active site 359786006590 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 359786006591 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 359786006592 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 359786006593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786006594 S-adenosylmethionine binding site [chemical binding]; other site 359786006595 peptide chain release factor 1; Validated; Region: prfA; PRK00591 359786006596 This domain is found in peptide chain release factors; Region: PCRF; smart00937 359786006597 RF-1 domain; Region: RF-1; pfam00472 359786006598 thymidine kinase; Provisional; Region: PRK04296 359786006599 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 359786006600 transcription termination factor Rho; Provisional; Region: rho; PRK09376 359786006601 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 359786006602 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 359786006603 RNA binding site [nucleotide binding]; other site 359786006604 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 359786006605 multimer interface [polypeptide binding]; other site 359786006606 Walker A motif; other site 359786006607 ATP binding site [chemical binding]; other site 359786006608 Walker B motif; other site 359786006609 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 359786006610 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 359786006611 NAD binding site [chemical binding]; other site 359786006612 catalytic residues [active] 359786006613 Predicted transcriptional regulators [Transcription]; Region: COG1733 359786006614 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 359786006615 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 359786006616 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 359786006617 hinge; other site 359786006618 active site 359786006619 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 359786006620 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 359786006621 intersubunit interface [polypeptide binding]; other site 359786006622 active site 359786006623 zinc binding site [ion binding]; other site 359786006624 Na+ binding site [ion binding]; other site 359786006625 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 359786006626 CTP synthetase; Validated; Region: pyrG; PRK05380 359786006627 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 359786006628 Catalytic site [active] 359786006629 active site 359786006630 UTP binding site [chemical binding]; other site 359786006631 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 359786006632 active site 359786006633 putative oxyanion hole; other site 359786006634 catalytic triad [active] 359786006635 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 359786006636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786006637 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 359786006638 Coenzyme A binding pocket [chemical binding]; other site 359786006639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 359786006640 Coenzyme A binding pocket [chemical binding]; other site 359786006641 pantothenate kinase; Provisional; Region: PRK13317 359786006642 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 359786006643 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 359786006644 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 359786006645 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 359786006646 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 359786006647 metal binding site [ion binding]; metal-binding site 359786006648 S-ribosylhomocysteinase; Provisional; Region: PRK02260 359786006649 Predicted membrane protein [Function unknown]; Region: COG4270 359786006650 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 359786006651 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 359786006652 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 359786006653 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 359786006654 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 359786006655 intersubunit interface [polypeptide binding]; other site 359786006656 active site 359786006657 catalytic residue [active] 359786006658 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 359786006659 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 359786006660 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 359786006661 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 359786006662 dimerization interface [polypeptide binding]; other site 359786006663 DPS ferroxidase diiron center [ion binding]; other site 359786006664 ion pore; other site 359786006665 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 359786006666 EVE domain; Region: EVE; cl00728 359786006667 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 359786006668 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 359786006669 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 359786006670 NADH(P)-binding; Region: NAD_binding_10; pfam13460 359786006671 NAD(P) binding site [chemical binding]; other site 359786006672 putative active site [active] 359786006673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 359786006674 dimerization interface [polypeptide binding]; other site 359786006675 putative DNA binding site [nucleotide binding]; other site 359786006676 putative Zn2+ binding site [ion binding]; other site 359786006677 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 359786006678 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 359786006679 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 359786006680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786006681 active site 359786006682 motif I; other site 359786006683 motif II; other site 359786006684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786006685 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 359786006686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786006687 Walker A/P-loop; other site 359786006688 ATP binding site [chemical binding]; other site 359786006689 Q-loop/lid; other site 359786006690 ABC transporter signature motif; other site 359786006691 Walker B; other site 359786006692 D-loop; other site 359786006693 H-loop/switch region; other site 359786006694 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 359786006695 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 359786006696 glutaminase active site [active] 359786006697 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 359786006698 dimer interface [polypeptide binding]; other site 359786006699 active site 359786006700 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 359786006701 dimer interface [polypeptide binding]; other site 359786006702 active site 359786006703 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 359786006704 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 359786006705 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 359786006706 active site 359786006707 P-loop; other site 359786006708 phosphorylation site [posttranslational modification] 359786006709 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 359786006710 HTH domain; Region: HTH_11; pfam08279 359786006711 Mga helix-turn-helix domain; Region: Mga; pfam05043 359786006712 PRD domain; Region: PRD; pfam00874 359786006713 PRD domain; Region: PRD; pfam00874 359786006714 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 359786006715 active site 359786006716 P-loop; other site 359786006717 phosphorylation site [posttranslational modification] 359786006718 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 359786006719 active site 359786006720 phosphorylation site [posttranslational modification] 359786006721 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 359786006722 active site 359786006723 phosphorylation site [posttranslational modification] 359786006724 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 359786006725 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 359786006726 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 359786006727 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786006728 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 359786006729 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786006730 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786006731 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786006732 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786006733 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786006734 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786006735 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 359786006736 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 359786006737 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 359786006738 active site 359786006739 substrate binding site [chemical binding]; other site 359786006740 metal binding site [ion binding]; metal-binding site 359786006741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 359786006742 YbbR-like protein; Region: YbbR; pfam07949 359786006743 TIGR00159 family protein; Region: TIGR00159 359786006744 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 359786006745 Arginase family; Region: Arginase; cd09989 359786006746 active site 359786006747 Mn binding site [ion binding]; other site 359786006748 oligomer interface [polypeptide binding]; other site 359786006749 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 359786006750 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 359786006751 Walker A motif; other site 359786006752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786006753 Major Facilitator Superfamily; Region: MFS_1; pfam07690 359786006754 putative substrate translocation pore; other site 359786006755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786006756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 359786006757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786006758 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 359786006759 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 359786006760 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 359786006761 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 359786006762 substrate binding site; other site 359786006763 dimerization interface; other site 359786006764 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 359786006765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 359786006766 Nucleoside recognition; Region: Gate; pfam07670 359786006767 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 359786006768 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786006769 ABC-ATPase subunit interface; other site 359786006770 dimer interface [polypeptide binding]; other site 359786006771 putative PBP binding regions; other site 359786006772 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 359786006773 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 359786006774 ABC-ATPase subunit interface; other site 359786006775 dimer interface [polypeptide binding]; other site 359786006776 putative PBP binding regions; other site 359786006777 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 359786006778 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 359786006779 siderophore binding site; other site 359786006780 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 359786006781 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 359786006782 dimer interface [polypeptide binding]; other site 359786006783 active site 359786006784 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 359786006785 substrate binding site [chemical binding]; other site 359786006786 catalytic residue [active] 359786006787 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 359786006788 IucA / IucC family; Region: IucA_IucC; pfam04183 359786006789 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 359786006790 H+ Antiporter protein; Region: 2A0121; TIGR00900 359786006791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786006792 putative substrate translocation pore; other site 359786006793 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 359786006794 IucA / IucC family; Region: IucA_IucC; pfam04183 359786006795 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 359786006796 Asp23 family; Region: Asp23; pfam03780 359786006797 Small integral membrane protein [Function unknown]; Region: COG5547 359786006798 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 359786006799 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 359786006800 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 359786006801 putative NAD(P) binding site [chemical binding]; other site 359786006802 dimer interface [polypeptide binding]; other site 359786006803 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 359786006804 Prostaglandin dehydrogenases; Region: PGDH; cd05288 359786006805 NAD(P) binding site [chemical binding]; other site 359786006806 substrate binding site [chemical binding]; other site 359786006807 dimer interface [polypeptide binding]; other site 359786006808 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 359786006809 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 359786006810 beta-galactosidase; Region: BGL; TIGR03356 359786006811 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 359786006812 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 359786006813 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 359786006814 active site 359786006815 P-loop; other site 359786006816 phosphorylation site [posttranslational modification] 359786006817 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 359786006818 methionine cluster; other site 359786006819 active site 359786006820 phosphorylation site [posttranslational modification] 359786006821 metal binding site [ion binding]; metal-binding site 359786006822 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 359786006823 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 359786006824 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 359786006825 putative substrate binding site [chemical binding]; other site 359786006826 putative ATP binding site [chemical binding]; other site 359786006827 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 359786006828 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 359786006829 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 359786006830 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 359786006831 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 359786006832 NAD-dependent deacetylase; Provisional; Region: PRK00481 359786006833 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 359786006834 NAD+ binding site [chemical binding]; other site 359786006835 substrate binding site [chemical binding]; other site 359786006836 putative Zn binding site [ion binding]; other site 359786006837 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 359786006838 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 359786006839 active site 359786006840 catalytic tetrad [active] 359786006841 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 359786006842 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 359786006843 DNA binding residues [nucleotide binding] 359786006844 putative dimer interface [polypeptide binding]; other site 359786006845 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 359786006846 substrate binding site [chemical binding]; other site 359786006847 catalytic residues [active] 359786006848 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 359786006849 Peptidase family M23; Region: Peptidase_M23; pfam01551 359786006850 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 359786006851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 359786006852 active site 359786006853 motif I; other site 359786006854 motif II; other site 359786006855 MAP domain; Region: MAP; pfam03642 359786006856 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 359786006857 acetolactate synthase; Reviewed; Region: PRK08617 359786006858 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 359786006859 PYR/PP interface [polypeptide binding]; other site 359786006860 dimer interface [polypeptide binding]; other site 359786006861 TPP binding site [chemical binding]; other site 359786006862 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 359786006863 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 359786006864 TPP-binding site [chemical binding]; other site 359786006865 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 359786006866 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 359786006867 putative active site [active] 359786006868 putative NTP binding site [chemical binding]; other site 359786006869 putative nucleic acid binding site [nucleotide binding]; other site 359786006870 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 359786006871 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 359786006872 23S rRNA interface [nucleotide binding]; other site 359786006873 L3 interface [polypeptide binding]; other site 359786006874 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 359786006875 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 359786006876 dimerization interface 3.5A [polypeptide binding]; other site 359786006877 active site 359786006878 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 359786006879 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 359786006880 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 359786006881 Walker A/P-loop; other site 359786006882 ATP binding site [chemical binding]; other site 359786006883 Q-loop/lid; other site 359786006884 ABC transporter signature motif; other site 359786006885 Walker B; other site 359786006886 D-loop; other site 359786006887 H-loop/switch region; other site 359786006888 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 359786006889 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 359786006890 Walker A/P-loop; other site 359786006891 ATP binding site [chemical binding]; other site 359786006892 Q-loop/lid; other site 359786006893 ABC transporter signature motif; other site 359786006894 Walker B; other site 359786006895 D-loop; other site 359786006896 H-loop/switch region; other site 359786006897 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 359786006898 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 359786006899 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 359786006900 alphaNTD homodimer interface [polypeptide binding]; other site 359786006901 alphaNTD - beta interaction site [polypeptide binding]; other site 359786006902 alphaNTD - beta' interaction site [polypeptide binding]; other site 359786006903 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 359786006904 30S ribosomal protein S11; Validated; Region: PRK05309 359786006905 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 359786006906 30S ribosomal protein S13; Region: bact_S13; TIGR03631 359786006907 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 359786006908 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 359786006909 rRNA binding site [nucleotide binding]; other site 359786006910 predicted 30S ribosome binding site; other site 359786006911 adenylate kinase; Reviewed; Region: adk; PRK00279 359786006912 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 359786006913 AMP-binding site [chemical binding]; other site 359786006914 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 359786006915 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 359786006916 SecY translocase; Region: SecY; pfam00344 359786006917 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 359786006918 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 359786006919 23S rRNA binding site [nucleotide binding]; other site 359786006920 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 359786006921 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 359786006922 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 359786006923 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 359786006924 5S rRNA interface [nucleotide binding]; other site 359786006925 L27 interface [polypeptide binding]; other site 359786006926 23S rRNA interface [nucleotide binding]; other site 359786006927 L5 interface [polypeptide binding]; other site 359786006928 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 359786006929 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 359786006930 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 359786006931 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 359786006932 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 359786006933 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 359786006934 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 359786006935 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 359786006936 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 359786006937 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 359786006938 RNA binding site [nucleotide binding]; other site 359786006939 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 359786006940 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 359786006941 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 359786006942 23S rRNA interface [nucleotide binding]; other site 359786006943 putative translocon interaction site; other site 359786006944 signal recognition particle (SRP54) interaction site; other site 359786006945 L23 interface [polypeptide binding]; other site 359786006946 trigger factor interaction site; other site 359786006947 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 359786006948 23S rRNA interface [nucleotide binding]; other site 359786006949 5S rRNA interface [nucleotide binding]; other site 359786006950 putative antibiotic binding site [chemical binding]; other site 359786006951 L25 interface [polypeptide binding]; other site 359786006952 L27 interface [polypeptide binding]; other site 359786006953 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 359786006954 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 359786006955 G-X-X-G motif; other site 359786006956 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 359786006957 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 359786006958 putative translocon binding site; other site 359786006959 protein-rRNA interface [nucleotide binding]; other site 359786006960 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 359786006961 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 359786006962 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 359786006963 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 359786006964 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 359786006965 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 359786006966 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 359786006967 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 359786006968 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 359786006969 DNA topoisomerase III; Provisional; Region: PRK07726 359786006970 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 359786006971 active site 359786006972 putative interdomain interaction site [polypeptide binding]; other site 359786006973 putative metal-binding site [ion binding]; other site 359786006974 putative nucleotide binding site [chemical binding]; other site 359786006975 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 359786006976 domain I; other site 359786006977 DNA binding groove [nucleotide binding] 359786006978 phosphate binding site [ion binding]; other site 359786006979 domain II; other site 359786006980 domain III; other site 359786006981 nucleotide binding site [chemical binding]; other site 359786006982 catalytic site [active] 359786006983 domain IV; other site 359786006984 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 359786006985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786006986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 359786006987 Coenzyme A binding pocket [chemical binding]; other site 359786006988 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 359786006989 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 359786006990 Predicted permeases [General function prediction only]; Region: COG0679 359786006991 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 359786006992 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 359786006993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 359786006994 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 359786006995 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 359786006996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786006997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 359786006998 putative substrate translocation pore; other site 359786006999 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786007000 Transcriptional regulators [Transcription]; Region: MarR; COG1846 359786007001 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 359786007002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 359786007003 FeS/SAM binding site; other site 359786007004 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 359786007005 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 359786007006 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 359786007007 GTP binding site; other site 359786007008 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 359786007009 MoaE interaction surface [polypeptide binding]; other site 359786007010 MoeB interaction surface [polypeptide binding]; other site 359786007011 thiocarboxylated glycine; other site 359786007012 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 359786007013 MoaE homodimer interface [polypeptide binding]; other site 359786007014 MoaD interaction [polypeptide binding]; other site 359786007015 active site residues [active] 359786007016 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 359786007017 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 359786007018 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 359786007019 dimer interface [polypeptide binding]; other site 359786007020 putative functional site; other site 359786007021 putative MPT binding site; other site 359786007022 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 359786007023 trimer interface [polypeptide binding]; other site 359786007024 dimer interface [polypeptide binding]; other site 359786007025 putative active site [active] 359786007026 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 359786007027 MPT binding site; other site 359786007028 trimer interface [polypeptide binding]; other site 359786007029 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 359786007030 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 359786007031 ATP binding site [chemical binding]; other site 359786007032 substrate interface [chemical binding]; other site 359786007033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786007034 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 359786007035 Walker A/P-loop; other site 359786007036 ATP binding site [chemical binding]; other site 359786007037 Q-loop/lid; other site 359786007038 ABC transporter signature motif; other site 359786007039 Walker B; other site 359786007040 D-loop; other site 359786007041 H-loop/switch region; other site 359786007042 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 359786007043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786007044 dimer interface [polypeptide binding]; other site 359786007045 conserved gate region; other site 359786007046 putative PBP binding loops; other site 359786007047 ABC-ATPase subunit interface; other site 359786007048 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 359786007049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 359786007050 substrate binding pocket [chemical binding]; other site 359786007051 membrane-bound complex binding site; other site 359786007052 hinge residues; other site 359786007053 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 359786007054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786007055 Coenzyme A binding pocket [chemical binding]; other site 359786007056 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 359786007057 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 359786007058 active site 359786007059 dimerization interface [polypeptide binding]; other site 359786007060 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 359786007061 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 359786007062 intersubunit interface [polypeptide binding]; other site 359786007063 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 359786007064 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 359786007065 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 359786007066 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 359786007067 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 359786007068 alpha-gamma subunit interface [polypeptide binding]; other site 359786007069 beta-gamma subunit interface [polypeptide binding]; other site 359786007070 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 359786007071 gamma-beta subunit interface [polypeptide binding]; other site 359786007072 alpha-beta subunit interface [polypeptide binding]; other site 359786007073 urease subunit alpha; Reviewed; Region: ureC; PRK13207 359786007074 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 359786007075 subunit interactions [polypeptide binding]; other site 359786007076 active site 359786007077 flap region; other site 359786007078 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 359786007079 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 359786007080 dimer interface [polypeptide binding]; other site 359786007081 catalytic residues [active] 359786007082 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 359786007083 UreF; Region: UreF; pfam01730 359786007084 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 359786007085 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 359786007086 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786007087 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786007088 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786007089 Transcriptional regulators [Transcription]; Region: MarR; COG1846 359786007090 Helix-turn-helix domain; Region: HTH_18; pfam12833 359786007091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 359786007092 Surface antigen [General function prediction only]; Region: COG3942 359786007093 CHAP domain; Region: CHAP; pfam05257 359786007094 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 359786007095 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 359786007096 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 359786007097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 359786007098 Surface antigen [General function prediction only]; Region: COG3942 359786007099 CHAP domain; Region: CHAP; pfam05257 359786007100 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 359786007101 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 359786007102 putative ligand binding site [chemical binding]; other site 359786007103 putative NAD binding site [chemical binding]; other site 359786007104 catalytic site [active] 359786007105 hypothetical protein; Provisional; Region: PRK06753 359786007106 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 359786007107 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 359786007108 Lysozyme subfamily 2; Region: LYZ2; smart00047 359786007109 Uncharacterized conserved protein [Function unknown]; Region: COG2427 359786007110 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 359786007111 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 359786007112 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 359786007113 4Fe-4S binding domain; Region: Fer4; pfam00037 359786007114 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 359786007115 [4Fe-4S] binding site [ion binding]; other site 359786007116 molybdopterin cofactor binding site; other site 359786007117 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 359786007118 molybdopterin cofactor binding site; other site 359786007119 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 359786007120 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 359786007121 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 359786007122 active site 359786007123 Predicted transcriptional regulator [Transcription]; Region: COG2378 359786007124 HTH domain; Region: HTH_11; pfam08279 359786007125 CAAX protease self-immunity; Region: Abi; pfam02517 359786007126 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 359786007127 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 359786007128 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 359786007129 putative active site [active] 359786007130 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 359786007131 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 359786007132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786007133 active site 359786007134 motif I; other site 359786007135 motif II; other site 359786007136 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 359786007137 Sodium Bile acid symporter family; Region: SBF; pfam01758 359786007138 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 359786007139 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 359786007140 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 359786007141 active site turn [active] 359786007142 phosphorylation site [posttranslational modification] 359786007143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 359786007144 Transposase; Region: DDE_Tnp_ISL3; pfam01610 359786007145 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 359786007146 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 359786007147 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 359786007148 putative active site [active] 359786007149 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 359786007150 putative hydrophobic ligand binding site [chemical binding]; other site 359786007151 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 359786007152 oxidoreductase; Provisional; Region: PRK07985 359786007153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 359786007154 NAD(P) binding site [chemical binding]; other site 359786007155 active site 359786007156 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 359786007157 amidohydrolase; Region: amidohydrolases; TIGR01891 359786007158 metal binding site [ion binding]; metal-binding site 359786007159 dimer interface [polypeptide binding]; other site 359786007160 imidazolonepropionase; Validated; Region: PRK09356 359786007161 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 359786007162 active site 359786007163 urocanate hydratase; Provisional; Region: PRK05414 359786007164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 359786007165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 359786007166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 359786007167 dimerization interface [polypeptide binding]; other site 359786007168 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 359786007169 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 359786007170 putative active site [active] 359786007171 putative Mg binding site [ion binding]; other site 359786007172 formimidoylglutamase; Provisional; Region: PRK13775 359786007173 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 359786007174 putative active site [active] 359786007175 putative metal binding site [ion binding]; other site 359786007176 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 359786007177 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 359786007178 tetramer (dimer of dimers) interface [polypeptide binding]; other site 359786007179 active site 359786007180 dimer interface [polypeptide binding]; other site 359786007181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 359786007182 MOSC domain; Region: MOSC; pfam03473 359786007183 3-alpha domain; Region: 3-alpha; pfam03475 359786007184 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 359786007185 active site 359786007186 catalytic residues [active] 359786007187 Uncharacterized conserved protein [Function unknown]; Region: COG1742 359786007188 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 359786007189 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 359786007190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786007191 Walker A/P-loop; other site 359786007192 ATP binding site [chemical binding]; other site 359786007193 Q-loop/lid; other site 359786007194 ABC transporter signature motif; other site 359786007195 Walker B; other site 359786007196 D-loop; other site 359786007197 H-loop/switch region; other site 359786007198 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 359786007199 Predicted membrane protein [Function unknown]; Region: COG3152 359786007200 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 359786007201 active site 359786007202 DNA binding site [nucleotide binding] 359786007203 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 359786007204 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 359786007205 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 359786007206 homotetramer interface [polypeptide binding]; other site 359786007207 FMN binding site [chemical binding]; other site 359786007208 homodimer contacts [polypeptide binding]; other site 359786007209 putative active site [active] 359786007210 putative substrate binding site [chemical binding]; other site 359786007211 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 359786007212 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 359786007213 oligomer interface [polypeptide binding]; other site 359786007214 metal binding site [ion binding]; metal-binding site 359786007215 metal binding site [ion binding]; metal-binding site 359786007216 putative Cl binding site [ion binding]; other site 359786007217 aspartate ring; other site 359786007218 basic sphincter; other site 359786007219 hydrophobic gate; other site 359786007220 periplasmic entrance; other site 359786007221 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 359786007222 active site 359786007223 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 359786007224 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 359786007225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007226 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 359786007227 putative substrate translocation pore; other site 359786007228 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 359786007229 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 359786007230 HlyD family secretion protein; Region: HlyD_3; pfam13437 359786007231 lipoyl-biotinyl attachment site [posttranslational modification]; other site 359786007232 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 359786007233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007234 putative substrate translocation pore; other site 359786007235 Predicted membrane protein [Function unknown]; Region: COG4640 359786007236 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 359786007237 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 359786007238 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 359786007239 putative Zn2+ binding site [ion binding]; other site 359786007240 putative DNA binding site [nucleotide binding]; other site 359786007241 Uncharacterized conserved protein [Function unknown]; Region: COG1434 359786007242 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 359786007243 putative active site [active] 359786007244 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 359786007245 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 359786007246 Walker A/P-loop; other site 359786007247 ATP binding site [chemical binding]; other site 359786007248 Q-loop/lid; other site 359786007249 ABC transporter signature motif; other site 359786007250 Walker B; other site 359786007251 D-loop; other site 359786007252 H-loop/switch region; other site 359786007253 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 359786007254 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 359786007255 FtsX-like permease family; Region: FtsX; pfam02687 359786007256 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 359786007257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786007258 active site 359786007259 phosphorylation site [posttranslational modification] 359786007260 intermolecular recognition site; other site 359786007261 dimerization interface [polypeptide binding]; other site 359786007262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 359786007263 DNA binding site [nucleotide binding] 359786007264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 359786007265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 359786007266 dimerization interface [polypeptide binding]; other site 359786007267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 359786007268 dimer interface [polypeptide binding]; other site 359786007269 phosphorylation site [posttranslational modification] 359786007270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786007271 ATP binding site [chemical binding]; other site 359786007272 Mg2+ binding site [ion binding]; other site 359786007273 G-X-G motif; other site 359786007274 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 359786007275 LytTr DNA-binding domain; Region: LytTR; smart00850 359786007276 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 359786007277 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 359786007278 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 359786007279 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 359786007280 L-lactate permease; Region: Lactate_perm; cl00701 359786007281 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 359786007282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786007283 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 359786007284 Coenzyme A binding pocket [chemical binding]; other site 359786007285 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 359786007286 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 359786007287 NAD(P) binding site [chemical binding]; other site 359786007288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786007289 Coenzyme A binding pocket [chemical binding]; other site 359786007290 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 359786007291 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 359786007292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786007293 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 359786007294 Predicted membrane protein [Function unknown]; Region: COG1511 359786007295 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 359786007296 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 359786007297 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 359786007298 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 359786007299 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 359786007300 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 359786007301 Cl binding site [ion binding]; other site 359786007302 oligomer interface [polypeptide binding]; other site 359786007303 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 359786007304 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 359786007305 active site turn [active] 359786007306 phosphorylation site [posttranslational modification] 359786007307 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 359786007308 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 359786007309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 359786007310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 359786007311 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 359786007312 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 359786007313 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 359786007314 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 359786007315 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 359786007316 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 359786007317 MarR family; Region: MarR_2; pfam12802 359786007318 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 359786007319 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 359786007320 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 359786007321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007322 putative substrate translocation pore; other site 359786007323 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 359786007324 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 359786007325 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 359786007326 DNA binding residues [nucleotide binding] 359786007327 dimer interface [polypeptide binding]; other site 359786007328 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 359786007329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 359786007330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786007331 active site 359786007332 phosphorylation site [posttranslational modification] 359786007333 intermolecular recognition site; other site 359786007334 dimerization interface [polypeptide binding]; other site 359786007335 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 359786007336 DNA binding residues [nucleotide binding] 359786007337 dimerization interface [polypeptide binding]; other site 359786007338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 359786007339 Histidine kinase; Region: HisKA_3; pfam07730 359786007340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786007341 ATP binding site [chemical binding]; other site 359786007342 Mg2+ binding site [ion binding]; other site 359786007343 G-X-G motif; other site 359786007344 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 359786007345 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 359786007346 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 359786007347 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 359786007348 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 359786007349 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 359786007350 active site 359786007351 SAM binding site [chemical binding]; other site 359786007352 homodimer interface [polypeptide binding]; other site 359786007353 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 359786007354 [2Fe-2S] cluster binding site [ion binding]; other site 359786007355 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 359786007356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 359786007357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 359786007358 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 359786007359 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 359786007360 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 359786007361 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 359786007362 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 359786007363 putative active site [active] 359786007364 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 359786007365 active site 359786007366 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 359786007367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786007368 Coenzyme A binding pocket [chemical binding]; other site 359786007369 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 359786007370 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 359786007371 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 359786007372 putative hydrophobic ligand binding site [chemical binding]; other site 359786007373 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 359786007374 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 359786007375 intersubunit interface [polypeptide binding]; other site 359786007376 YodA lipocalin-like domain; Region: YodA; pfam09223 359786007377 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 359786007378 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 359786007379 Thioredoxin; Region: Thioredoxin_4; cl17273 359786007380 FemAB family; Region: FemAB; pfam02388 359786007381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 359786007382 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 359786007383 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 359786007384 Walker A/P-loop; other site 359786007385 ATP binding site [chemical binding]; other site 359786007386 Q-loop/lid; other site 359786007387 ABC transporter signature motif; other site 359786007388 Walker B; other site 359786007389 D-loop; other site 359786007390 H-loop/switch region; other site 359786007391 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 359786007392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786007393 dimer interface [polypeptide binding]; other site 359786007394 conserved gate region; other site 359786007395 putative PBP binding loops; other site 359786007396 ABC-ATPase subunit interface; other site 359786007397 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 359786007398 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 359786007399 substrate binding pocket [chemical binding]; other site 359786007400 membrane-bound complex binding site; other site 359786007401 hinge residues; other site 359786007402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007403 Major Facilitator Superfamily; Region: MFS_1; pfam07690 359786007404 putative substrate translocation pore; other site 359786007405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007406 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 359786007407 catalytic core [active] 359786007408 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 359786007409 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 359786007410 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 359786007411 B domain; Region: B; pfam02216 359786007412 B domain; Region: B; pfam02216 359786007413 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 359786007414 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 359786007415 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 359786007416 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 359786007417 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 359786007418 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 359786007419 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 359786007420 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 359786007421 catalytic residue [active] 359786007422 biotin synthase; Validated; Region: PRK06256 359786007423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 359786007424 FeS/SAM binding site; other site 359786007425 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 359786007426 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 359786007427 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 359786007428 inhibitor-cofactor binding pocket; inhibition site 359786007429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786007430 catalytic residue [active] 359786007431 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 359786007432 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 359786007433 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 359786007434 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 359786007435 Walker A/P-loop; other site 359786007436 ATP binding site [chemical binding]; other site 359786007437 Q-loop/lid; other site 359786007438 ABC transporter signature motif; other site 359786007439 Walker B; other site 359786007440 D-loop; other site 359786007441 H-loop/switch region; other site 359786007442 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 359786007443 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 359786007444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786007445 Walker A/P-loop; other site 359786007446 ATP binding site [chemical binding]; other site 359786007447 Q-loop/lid; other site 359786007448 ABC transporter signature motif; other site 359786007449 Walker B; other site 359786007450 D-loop; other site 359786007451 H-loop/switch region; other site 359786007452 Predicted membrane protein [Function unknown]; Region: COG2246 359786007453 GtrA-like protein; Region: GtrA; pfam04138 359786007454 glycerate kinase; Region: TIGR00045 359786007455 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 359786007456 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 359786007457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007458 putative substrate translocation pore; other site 359786007459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 359786007460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 359786007461 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 359786007462 putative phosphoesterase; Region: acc_ester; TIGR03729 359786007463 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 359786007464 Spore germination protein; Region: Spore_permease; cl17796 359786007465 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 359786007466 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 359786007467 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 359786007468 Beta-lactamase; Region: Beta-lactamase; pfam00144 359786007469 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 359786007470 extended (e) SDRs; Region: SDR_e; cd08946 359786007471 NAD(P) binding site [chemical binding]; other site 359786007472 active site 359786007473 substrate binding site [chemical binding]; other site 359786007474 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 359786007475 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 359786007476 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 359786007477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007478 putative substrate translocation pore; other site 359786007479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786007481 dimer interface [polypeptide binding]; other site 359786007482 conserved gate region; other site 359786007483 ABC-ATPase subunit interface; other site 359786007484 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 359786007485 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 359786007486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786007487 dimer interface [polypeptide binding]; other site 359786007488 conserved gate region; other site 359786007489 putative PBP binding loops; other site 359786007490 ABC-ATPase subunit interface; other site 359786007491 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 359786007492 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 359786007493 Walker A/P-loop; other site 359786007494 ATP binding site [chemical binding]; other site 359786007495 Q-loop/lid; other site 359786007496 ABC transporter signature motif; other site 359786007497 Walker B; other site 359786007498 D-loop; other site 359786007499 H-loop/switch region; other site 359786007500 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 359786007501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 359786007502 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 359786007503 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 359786007504 amino acid transporter; Region: 2A0306; TIGR00909 359786007505 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 359786007506 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 359786007507 substrate binding pocket [chemical binding]; other site 359786007508 catalytic triad [active] 359786007509 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 359786007510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007511 putative substrate translocation pore; other site 359786007512 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 359786007513 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 359786007514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786007515 Walker A/P-loop; other site 359786007516 ATP binding site [chemical binding]; other site 359786007517 Q-loop/lid; other site 359786007518 ABC transporter signature motif; other site 359786007519 Walker B; other site 359786007520 D-loop; other site 359786007521 H-loop/switch region; other site 359786007522 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 359786007523 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 359786007524 oligomer interface [polypeptide binding]; other site 359786007525 active site 359786007526 metal binding site [ion binding]; metal-binding site 359786007527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 359786007528 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 359786007529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 359786007530 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 359786007531 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 359786007532 active site 359786007533 FMN binding site [chemical binding]; other site 359786007534 substrate binding site [chemical binding]; other site 359786007535 3Fe-4S cluster binding site [ion binding]; other site 359786007536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 359786007538 putative substrate translocation pore; other site 359786007539 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 359786007540 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 359786007541 Walker A/P-loop; other site 359786007542 ATP binding site [chemical binding]; other site 359786007543 Q-loop/lid; other site 359786007544 ABC transporter signature motif; other site 359786007545 Walker B; other site 359786007546 D-loop; other site 359786007547 H-loop/switch region; other site 359786007548 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 359786007549 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 359786007550 Walker A/P-loop; other site 359786007551 ATP binding site [chemical binding]; other site 359786007552 Q-loop/lid; other site 359786007553 ABC transporter signature motif; other site 359786007554 Walker B; other site 359786007555 D-loop; other site 359786007556 H-loop/switch region; other site 359786007557 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 359786007558 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 359786007559 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 359786007560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786007561 dimer interface [polypeptide binding]; other site 359786007562 conserved gate region; other site 359786007563 ABC-ATPase subunit interface; other site 359786007564 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 359786007565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 359786007566 dimer interface [polypeptide binding]; other site 359786007567 conserved gate region; other site 359786007568 putative PBP binding loops; other site 359786007569 ABC-ATPase subunit interface; other site 359786007570 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 359786007571 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 359786007572 substrate binding site [chemical binding]; other site 359786007573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 359786007574 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 359786007575 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 359786007576 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 359786007577 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 359786007578 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 359786007579 short chain dehydrogenase; Validated; Region: PRK08589 359786007580 classical (c) SDRs; Region: SDR_c; cd05233 359786007581 NAD(P) binding site [chemical binding]; other site 359786007582 active site 359786007583 AbgT putative transporter family; Region: ABG_transport; pfam03806 359786007584 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 359786007585 Uncharacterized conserved protein [Function unknown]; Region: COG2128 359786007586 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 359786007587 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 359786007588 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 359786007589 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 359786007590 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 359786007591 classical (c) SDRs; Region: SDR_c; cd05233 359786007592 NAD(P) binding site [chemical binding]; other site 359786007593 active site 359786007594 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 359786007595 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786007596 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786007597 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786007598 Protein of unknown function, DUF576; Region: DUF576; pfam04507 359786007599 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 359786007600 PLD-like domain; Region: PLDc_2; pfam13091 359786007601 putative homodimer interface [polypeptide binding]; other site 359786007602 putative active site [active] 359786007603 catalytic site [active] 359786007604 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 359786007605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 359786007606 ATP binding site [chemical binding]; other site 359786007607 putative Mg++ binding site [ion binding]; other site 359786007608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 359786007609 nucleotide binding region [chemical binding]; other site 359786007610 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 359786007611 ATP-binding site [chemical binding]; other site 359786007612 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 359786007613 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 359786007614 active site 359786007615 8-oxo-dGMP binding site [chemical binding]; other site 359786007616 nudix motif; other site 359786007617 metal binding site [ion binding]; metal-binding site 359786007618 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 359786007619 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 359786007620 active site 359786007621 substrate binding site [chemical binding]; other site 359786007622 metal binding site [ion binding]; metal-binding site 359786007623 H+ Antiporter protein; Region: 2A0121; TIGR00900 359786007624 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786007625 legume lectins; Region: lectin_L-type; cl14058 359786007626 homotetramer interaction site [polypeptide binding]; other site 359786007627 carbohydrate binding site [chemical binding]; other site 359786007628 metal binding site [ion binding]; metal-binding site 359786007629 G5 domain; Region: G5; pfam07501 359786007630 G5 domain; Region: G5; pfam07501 359786007631 G5 domain; Region: G5; pfam07501 359786007632 G5 domain; Region: G5; pfam07501 359786007633 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 359786007634 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786007635 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 359786007636 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786007637 Transcriptional regulators [Transcription]; Region: MarR; COG1846 359786007638 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 359786007639 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 359786007640 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 359786007641 active site 359786007642 tetramer interface; other site 359786007643 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786007644 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 359786007645 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 359786007646 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786007647 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 359786007648 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 359786007649 GntP family permease; Region: GntP_permease; pfam02447 359786007650 fructuronate transporter; Provisional; Region: PRK10034; cl15264 359786007651 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 359786007652 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 359786007653 N- and C-terminal domain interface [polypeptide binding]; other site 359786007654 active site 359786007655 catalytic site [active] 359786007656 metal binding site [ion binding]; metal-binding site 359786007657 carbohydrate binding site [chemical binding]; other site 359786007658 ATP binding site [chemical binding]; other site 359786007659 Transcriptional regulators [Transcription]; Region: GntR; COG1802 359786007660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 359786007661 DNA-binding site [nucleotide binding]; DNA binding site 359786007662 FCD domain; Region: FCD; pfam07729 359786007663 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 359786007664 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 359786007665 DNA binding residues [nucleotide binding] 359786007666 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 359786007667 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 359786007668 synthetase active site [active] 359786007669 NTP binding site [chemical binding]; other site 359786007670 metal binding site [ion binding]; metal-binding site 359786007671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 359786007672 Predicted membrane protein [Function unknown]; Region: COG1289 359786007673 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 359786007674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 359786007675 D-galactonate transporter; Region: 2A0114; TIGR00893 359786007676 putative substrate translocation pore; other site 359786007677 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 359786007678 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 359786007679 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 359786007680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786007681 Walker A/P-loop; other site 359786007682 ATP binding site [chemical binding]; other site 359786007683 Q-loop/lid; other site 359786007684 ABC transporter signature motif; other site 359786007685 Walker B; other site 359786007686 D-loop; other site 359786007687 H-loop/switch region; other site 359786007688 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 359786007689 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 359786007690 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 359786007691 Uncharacterized membrane protein [Function unknown]; Region: COG3949 359786007692 Predicted esterase [General function prediction only]; Region: COG0400 359786007693 putative hydrolase; Provisional; Region: PRK11460 359786007694 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 359786007695 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 359786007696 Zn binding site [ion binding]; other site 359786007697 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 359786007698 Zn binding site [ion binding]; other site 359786007699 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 359786007700 MarR family; Region: MarR; pfam01047 359786007701 Predicted acetyltransferase [General function prediction only]; Region: COG2388 359786007702 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 359786007703 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 359786007704 putative metal binding site [ion binding]; other site 359786007705 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 359786007706 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 359786007707 dimer interface [polypeptide binding]; other site 359786007708 FMN binding site [chemical binding]; other site 359786007709 D-lactate dehydrogenase; Provisional; Region: PRK12480 359786007710 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 359786007711 homodimer interface [polypeptide binding]; other site 359786007712 ligand binding site [chemical binding]; other site 359786007713 NAD binding site [chemical binding]; other site 359786007714 catalytic site [active] 359786007715 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 359786007716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 359786007717 active site 359786007718 motif I; other site 359786007719 motif II; other site 359786007720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 359786007721 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 359786007722 Walker A/P-loop; other site 359786007723 ATP binding site [chemical binding]; other site 359786007724 Q-loop/lid; other site 359786007725 ABC transporter signature motif; other site 359786007726 Walker B; other site 359786007727 D-loop; other site 359786007728 H-loop/switch region; other site 359786007729 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 359786007730 active site 359786007731 catalytic site [active] 359786007732 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 359786007733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786007734 Coenzyme A binding pocket [chemical binding]; other site 359786007735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 359786007736 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 359786007737 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 359786007738 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 359786007739 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 359786007740 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 359786007741 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 359786007742 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 359786007743 EamA-like transporter family; Region: EamA; pfam00892 359786007744 EamA-like transporter family; Region: EamA; pfam00892 359786007745 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 359786007746 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 359786007747 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 359786007748 catalytic residues [active] 359786007749 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 359786007750 active site 359786007751 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 359786007752 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 359786007753 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 359786007754 active site turn [active] 359786007755 phosphorylation site [posttranslational modification] 359786007756 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 359786007757 HPr interaction site; other site 359786007758 glycerol kinase (GK) interaction site [polypeptide binding]; other site 359786007759 active site 359786007760 phosphorylation site [posttranslational modification] 359786007761 pyruvate oxidase; Provisional; Region: PRK08611 359786007762 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 359786007763 PYR/PP interface [polypeptide binding]; other site 359786007764 tetramer interface [polypeptide binding]; other site 359786007765 dimer interface [polypeptide binding]; other site 359786007766 TPP binding site [chemical binding]; other site 359786007767 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 359786007768 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 359786007769 TPP-binding site [chemical binding]; other site 359786007770 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 359786007771 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 359786007772 Transcriptional regulator [Transcription]; Region: LysR; COG0583 359786007773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 359786007774 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 359786007775 putative dimerization interface [polypeptide binding]; other site 359786007776 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 359786007777 Surface antigen [General function prediction only]; Region: COG3942 359786007778 CHAP domain; Region: CHAP; pfam05257 359786007779 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 359786007780 homodimer interface [polypeptide binding]; other site 359786007781 catalytic residues [active] 359786007782 NAD binding site [chemical binding]; other site 359786007783 substrate binding pocket [chemical binding]; other site 359786007784 flexible flap; other site 359786007785 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 359786007786 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 359786007787 dimer interface [polypeptide binding]; other site 359786007788 active site 359786007789 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 359786007790 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 359786007791 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 359786007792 DNA binding site [nucleotide binding] 359786007793 active site 359786007794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786007795 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 359786007796 Walker A motif; other site 359786007797 ATP binding site [chemical binding]; other site 359786007798 Walker B motif; other site 359786007799 arginine finger; other site 359786007800 UvrB/uvrC motif; Region: UVR; pfam02151 359786007801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 359786007802 Walker A motif; other site 359786007803 ATP binding site [chemical binding]; other site 359786007804 Walker B motif; other site 359786007805 arginine finger; other site 359786007806 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 359786007807 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 359786007808 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 359786007809 G1 box; other site 359786007810 GTP/Mg2+ binding site [chemical binding]; other site 359786007811 Switch I region; other site 359786007812 G2 box; other site 359786007813 G3 box; other site 359786007814 Switch II region; other site 359786007815 G4 box; other site 359786007816 G5 box; other site 359786007817 Nucleoside recognition; Region: Gate; pfam07670 359786007818 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 359786007819 Nucleoside recognition; Region: Gate; pfam07670 359786007820 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 359786007821 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 359786007822 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 359786007823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 359786007824 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 359786007825 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 359786007826 Glutamate binding site [chemical binding]; other site 359786007827 homodimer interface [polypeptide binding]; other site 359786007828 NAD binding site [chemical binding]; other site 359786007829 catalytic residues [active] 359786007830 maltose O-acetyltransferase; Provisional; Region: PRK10092 359786007831 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 359786007832 active site 359786007833 substrate binding site [chemical binding]; other site 359786007834 trimer interface [polypeptide binding]; other site 359786007835 CoA binding site [chemical binding]; other site 359786007836 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 359786007837 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 359786007838 metal-binding site [ion binding] 359786007839 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 359786007840 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 359786007841 metal-binding site [ion binding] 359786007842 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 359786007843 Soluble P-type ATPase [General function prediction only]; Region: COG4087 359786007844 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 359786007845 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 359786007846 metal-binding site [ion binding] 359786007847 D-lactate dehydrogenase; Validated; Region: PRK08605 359786007848 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 359786007849 homodimer interface [polypeptide binding]; other site 359786007850 ligand binding site [chemical binding]; other site 359786007851 NAD binding site [chemical binding]; other site 359786007852 catalytic site [active] 359786007853 transaminase; Reviewed; Region: PRK08068 359786007854 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 359786007855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786007856 homodimer interface [polypeptide binding]; other site 359786007857 catalytic residue [active] 359786007858 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 359786007859 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 359786007860 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 359786007861 active site lid residues [active] 359786007862 substrate binding pocket [chemical binding]; other site 359786007863 catalytic residues [active] 359786007864 substrate-Mg2+ binding site; other site 359786007865 aspartate-rich region 1; other site 359786007866 aspartate-rich region 2; other site 359786007867 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 359786007868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 359786007869 active site 359786007870 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 359786007871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 359786007872 Surface antigen [General function prediction only]; Region: COG3942 359786007873 CHAP domain; Region: CHAP; pfam05257 359786007874 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 359786007875 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 359786007876 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 359786007877 catalytic triad [active] 359786007878 catalytic triad [active] 359786007879 oxyanion hole [active] 359786007880 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 359786007881 N-acetyl-D-glucosamine binding site [chemical binding]; other site 359786007882 catalytic residue [active] 359786007883 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 359786007884 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 359786007885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 359786007886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 359786007887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 359786007888 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 359786007889 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 359786007890 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 359786007891 NmrA-like family; Region: NmrA; pfam05368 359786007892 NADP binding site [chemical binding]; other site 359786007893 active site 359786007894 regulatory binding site [polypeptide binding]; other site 359786007895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 359786007896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 359786007897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 359786007898 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 359786007899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 359786007900 NAD(P) binding site [chemical binding]; other site 359786007901 active site 359786007902 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 359786007903 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 359786007904 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 359786007905 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 359786007906 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 359786007907 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 359786007908 Nucleoside recognition; Region: Gate; pfam07670 359786007909 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 359786007910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 359786007911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 359786007912 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 359786007913 Phosphotransferase enzyme family; Region: APH; pfam01636 359786007914 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 359786007915 active site 359786007916 ATP binding site [chemical binding]; other site 359786007917 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 359786007918 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 359786007919 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 359786007920 quinone interaction residues [chemical binding]; other site 359786007921 active site 359786007922 catalytic residues [active] 359786007923 FMN binding site [chemical binding]; other site 359786007924 substrate binding site [chemical binding]; other site 359786007925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 359786007926 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 359786007927 dimer interface [polypeptide binding]; other site 359786007928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 359786007929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 359786007930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 359786007931 Predicted acyl esterases [General function prediction only]; Region: COG2936 359786007932 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 359786007933 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 359786007934 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 359786007935 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 359786007936 tetramerization interface [polypeptide binding]; other site 359786007937 active site 359786007938 pantoate--beta-alanine ligase; Region: panC; TIGR00018 359786007939 Pantoate-beta-alanine ligase; Region: PanC; cd00560 359786007940 active site 359786007941 ATP-binding site [chemical binding]; other site 359786007942 pantoate-binding site; other site 359786007943 HXXH motif; other site 359786007944 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 359786007945 oligomerization interface [polypeptide binding]; other site 359786007946 active site 359786007947 metal binding site [ion binding]; metal-binding site 359786007948 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 359786007949 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 359786007950 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 359786007951 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 359786007952 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 359786007953 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 359786007954 tetramer (dimer of dimers) interface [polypeptide binding]; other site 359786007955 NAD binding site [chemical binding]; other site 359786007956 dimer interface [polypeptide binding]; other site 359786007957 substrate binding site [chemical binding]; other site 359786007958 amino acid transporter; Region: 2A0306; TIGR00909 359786007959 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 359786007960 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 359786007961 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 359786007962 inhibitor-cofactor binding pocket; inhibition site 359786007963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786007964 catalytic residue [active] 359786007965 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 359786007966 catalytic residue [active] 359786007967 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 359786007968 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 359786007969 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 359786007970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 359786007971 acyl-activating enzyme (AAE) consensus motif; other site 359786007972 AMP binding site [chemical binding]; other site 359786007973 active site 359786007974 CoA binding site [chemical binding]; other site 359786007975 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 359786007976 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 359786007977 choline dehydrogenase; Validated; Region: PRK02106 359786007978 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 359786007979 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 359786007980 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 359786007981 tetramerization interface [polypeptide binding]; other site 359786007982 NAD(P) binding site [chemical binding]; other site 359786007983 catalytic residues [active] 359786007984 Predicted transcriptional regulators [Transcription]; Region: COG1510 359786007985 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 359786007986 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 359786007987 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 359786007988 FeS/SAM binding site; other site 359786007989 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 359786007990 Class III ribonucleotide reductase; Region: RNR_III; cd01675 359786007991 effector binding site; other site 359786007992 active site 359786007993 Zn binding site [ion binding]; other site 359786007994 glycine loop; other site 359786007995 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 359786007996 Citrate transporter; Region: CitMHS; pfam03600 359786007997 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 359786007998 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 359786007999 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 359786008000 Flavodoxin; Region: Flavodoxin_1; pfam00258 359786008001 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 359786008002 FAD binding pocket [chemical binding]; other site 359786008003 FAD binding motif [chemical binding]; other site 359786008004 catalytic residues [active] 359786008005 NAD binding pocket [chemical binding]; other site 359786008006 phosphate binding motif [ion binding]; other site 359786008007 beta-alpha-beta structure motif; other site 359786008008 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 359786008009 catalytic residues [active] 359786008010 dimer interface [polypeptide binding]; other site 359786008011 FtsX-like permease family; Region: FtsX; pfam02687 359786008012 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 359786008013 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 359786008014 Walker A/P-loop; other site 359786008015 ATP binding site [chemical binding]; other site 359786008016 Q-loop/lid; other site 359786008017 ABC transporter signature motif; other site 359786008018 Walker B; other site 359786008019 D-loop; other site 359786008020 H-loop/switch region; other site 359786008021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 359786008022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 359786008023 ATP binding site [chemical binding]; other site 359786008024 Mg2+ binding site [ion binding]; other site 359786008025 G-X-G motif; other site 359786008026 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 359786008027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 359786008028 active site 359786008029 phosphorylation site [posttranslational modification] 359786008030 intermolecular recognition site; other site 359786008031 dimerization interface [polypeptide binding]; other site 359786008032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 359786008033 DNA binding site [nucleotide binding] 359786008034 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 359786008035 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 359786008036 dimer interface [polypeptide binding]; other site 359786008037 active site 359786008038 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 359786008039 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 359786008040 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 359786008041 MarR family; Region: MarR_2; pfam12802 359786008042 Predicted esterase [General function prediction only]; Region: COG0627 359786008043 S-formylglutathione hydrolase; Region: PLN02442 359786008044 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 359786008045 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 359786008046 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 359786008047 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 359786008048 ligand binding site [chemical binding]; other site 359786008049 flexible hinge region; other site 359786008050 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 359786008051 carbamate kinase; Reviewed; Region: PRK12686 359786008052 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 359786008053 putative substrate binding site [chemical binding]; other site 359786008054 nucleotide binding site [chemical binding]; other site 359786008055 nucleotide binding site [chemical binding]; other site 359786008056 homodimer interface [polypeptide binding]; other site 359786008057 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 359786008058 ornithine carbamoyltransferase; Validated; Region: PRK02102 359786008059 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 359786008060 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 359786008061 arginine deiminase; Provisional; Region: PRK01388 359786008062 Arginine repressor [Transcription]; Region: ArgR; COG1438 359786008063 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 359786008064 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 359786008065 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 359786008066 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 359786008067 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 359786008068 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 359786008069 active site 359786008070 Zn binding site [ion binding]; other site 359786008071 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 359786008072 HTH domain; Region: HTH_11; pfam08279 359786008073 PRD domain; Region: PRD; pfam00874 359786008074 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 359786008075 active site 359786008076 P-loop; other site 359786008077 phosphorylation site [posttranslational modification] 359786008078 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 359786008079 active site 359786008080 phosphorylation site [posttranslational modification] 359786008081 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 359786008082 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 359786008083 active site 359786008084 P-loop; other site 359786008085 phosphorylation site [posttranslational modification] 359786008086 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 359786008087 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 359786008088 active site 359786008089 phosphorylation site [posttranslational modification] 359786008090 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 359786008091 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 359786008092 Predicted membrane protein [Function unknown]; Region: COG1511 359786008093 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 359786008094 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 359786008095 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 359786008096 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 359786008097 CHAP domain; Region: CHAP; pfam05257 359786008098 Isochorismatase family; Region: Isochorismatase; pfam00857 359786008099 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 359786008100 catalytic triad [active] 359786008101 conserved cis-peptide bond; other site 359786008102 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 359786008103 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 359786008104 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 359786008105 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 359786008106 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 359786008107 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 359786008108 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 359786008109 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 359786008110 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 359786008111 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 359786008112 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 359786008113 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 359786008114 SecY translocase; Region: SecY; pfam00344 359786008115 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 359786008116 legume lectins; Region: lectin_L-type; cd01951 359786008117 homotetramer interaction site [polypeptide binding]; other site 359786008118 carbohydrate binding site [chemical binding]; other site 359786008119 metal binding site [ion binding]; metal-binding site 359786008120 Putative Ig domain; Region: He_PIG; pfam05345 359786008121 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 359786008122 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 359786008123 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 359786008124 methionine sulfoxide reductase A; Provisional; Region: PRK05528 359786008125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 359786008126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 359786008127 Coenzyme A binding pocket [chemical binding]; other site 359786008128 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 359786008129 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 359786008130 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 359786008131 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 359786008132 Chain length determinant protein; Region: Wzz; cl15801 359786008133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 359786008134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 359786008135 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 359786008136 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 359786008137 DXD motif; other site 359786008138 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 359786008139 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 359786008140 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 359786008141 Acyltransferase family; Region: Acyl_transf_3; pfam01757 359786008142 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 359786008143 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 359786008144 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 359786008145 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 359786008146 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 359786008147 metal binding site [ion binding]; metal-binding site 359786008148 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 359786008149 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 359786008150 substrate binding site [chemical binding]; other site 359786008151 glutamase interaction surface [polypeptide binding]; other site 359786008152 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 359786008153 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 359786008154 catalytic residues [active] 359786008155 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 359786008156 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 359786008157 putative active site [active] 359786008158 oxyanion strand; other site 359786008159 catalytic triad [active] 359786008160 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 359786008161 putative active site pocket [active] 359786008162 4-fold oligomerization interface [polypeptide binding]; other site 359786008163 metal binding residues [ion binding]; metal-binding site 359786008164 3-fold/trimer interface [polypeptide binding]; other site 359786008165 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 359786008166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 359786008167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 359786008168 homodimer interface [polypeptide binding]; other site 359786008169 catalytic residue [active] 359786008170 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 359786008171 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 359786008172 NAD binding site [chemical binding]; other site 359786008173 dimerization interface [polypeptide binding]; other site 359786008174 product binding site; other site 359786008175 substrate binding site [chemical binding]; other site 359786008176 zinc binding site [ion binding]; other site 359786008177 catalytic residues [active] 359786008178 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 359786008179 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 359786008180 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 359786008181 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 359786008182 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 359786008183 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 359786008184 putative active site [active] 359786008185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 359786008186 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 359786008187 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 359786008188 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 359786008189 Walker A/P-loop; other site 359786008190 ATP binding site [chemical binding]; other site 359786008191 Q-loop/lid; other site 359786008192 ABC transporter signature motif; other site 359786008193 Walker B; other site 359786008194 D-loop; other site 359786008195 H-loop/switch region; other site 359786008196 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 359786008197 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 359786008198 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 359786008199 Walker A/P-loop; other site 359786008200 ATP binding site [chemical binding]; other site 359786008201 Q-loop/lid; other site 359786008202 ABC transporter signature motif; other site 359786008203 Walker B; other site 359786008204 D-loop; other site 359786008205 H-loop/switch region; other site 359786008206 hypothetical protein; Provisional; Region: PRK13661 359786008207 Uncharacterized conserved protein [Function unknown]; Region: COG1912 359786008208 Uncharacterized conserved protein [Function unknown]; Region: COG2353 359786008209 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 359786008210 Strictosidine synthase; Region: Str_synth; pfam03088 359786008211 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 359786008212 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 359786008213 active site residue [active] 359786008214 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 359786008215 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 359786008216 putative substrate binding pocket [chemical binding]; other site 359786008217 AC domain interface; other site 359786008218 catalytic triad [active] 359786008219 AB domain interface; other site 359786008220 interchain disulfide; other site 359786008221 Predicted transcriptional regulators [Transcription]; Region: COG1695 359786008222 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 359786008223 DinB superfamily; Region: DinB_2; pfam12867 359786008224 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 359786008225 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 359786008226 transmembrane helices; other site 359786008227 Predicted permeases [General function prediction only]; Region: RarD; COG2962 359786008228 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 359786008229 hypothetical protein; Provisional; Region: PRK07758 359786008230 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 359786008231 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 359786008232 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 359786008233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 359786008234 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 359786008235 Walker A/P-loop; other site 359786008236 ATP binding site [chemical binding]; other site 359786008237 Q-loop/lid; other site 359786008238 ABC transporter signature motif; other site 359786008239 Walker B; other site 359786008240 D-loop; other site 359786008241 H-loop/switch region; other site 359786008242 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 359786008243 FtsX-like permease family; Region: FtsX; pfam02687 359786008244 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 359786008245 DNA-binding site [nucleotide binding]; DNA binding site 359786008246 RNA-binding motif; other site 359786008247 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 359786008248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 359786008249 non-specific DNA binding site [nucleotide binding]; other site 359786008250 salt bridge; other site 359786008251 sequence-specific DNA binding site [nucleotide binding]; other site 359786008252 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 359786008253 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 359786008254 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 359786008255 ParB-like nuclease domain; Region: ParBc; pfam02195 359786008256 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 359786008257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 359786008258 S-adenosylmethionine binding site [chemical binding]; other site 359786008259 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 359786008260 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 359786008261 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 359786008262 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 359786008263 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 359786008264 trmE is a tRNA modification GTPase; Region: trmE; cd04164 359786008265 G1 box; other site 359786008266 GTP/Mg2+ binding site [chemical binding]; other site 359786008267 Switch I region; other site 359786008268 G2 box; other site 359786008269 Switch II region; other site 359786008270 G3 box; other site 359786008271 G4 box; other site 359786008272 G5 box; other site 359786008273 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 359786008274 ribonuclease P; Reviewed; Region: rnpA; PRK00499