-- dump date   	20140620_073926
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
546342000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
546342000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
546342000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342000004	Walker A motif; other site
546342000005	ATP binding site [chemical binding]; other site
546342000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
546342000007	Walker B motif; other site
546342000008	arginine finger; other site
546342000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
546342000010	DnaA box-binding interface [nucleotide binding]; other site
546342000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
546342000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
546342000013	putative DNA binding surface [nucleotide binding]; other site
546342000014	dimer interface [polypeptide binding]; other site
546342000015	beta-clamp/clamp loader binding surface; other site
546342000016	beta-clamp/translesion DNA polymerase binding surface; other site
546342000017	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
546342000018	recF protein; Region: recf; TIGR00611
546342000019	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
546342000020	Walker A/P-loop; other site
546342000021	ATP binding site [chemical binding]; other site
546342000022	Q-loop/lid; other site
546342000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342000024	ABC transporter signature motif; other site
546342000025	Walker B; other site
546342000026	D-loop; other site
546342000027	H-loop/switch region; other site
546342000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
546342000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342000030	Mg2+ binding site [ion binding]; other site
546342000031	G-X-G motif; other site
546342000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
546342000033	anchoring element; other site
546342000034	dimer interface [polypeptide binding]; other site
546342000035	ATP binding site [chemical binding]; other site
546342000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
546342000037	active site
546342000038	putative metal-binding site [ion binding]; other site
546342000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
546342000040	DNA gyrase subunit A; Validated; Region: PRK05560
546342000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
546342000042	CAP-like domain; other site
546342000043	active site
546342000044	primary dimer interface [polypeptide binding]; other site
546342000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546342000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546342000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546342000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546342000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546342000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546342000051	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
546342000052	putative substrate binding site [chemical binding]; other site
546342000053	putative ATP binding site [chemical binding]; other site
546342000054	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
546342000055	active sites [active]
546342000056	tetramer interface [polypeptide binding]; other site
546342000057	seryl-tRNA synthetase; Provisional; Region: PRK05431
546342000058	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
546342000059	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
546342000060	dimer interface [polypeptide binding]; other site
546342000061	active site
546342000062	motif 1; other site
546342000063	motif 2; other site
546342000064	motif 3; other site
546342000065	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
546342000066	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
546342000067	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
546342000068	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
546342000069	Predicted membrane protein [Function unknown]; Region: COG4241
546342000070	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
546342000071	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
546342000072	DHH family; Region: DHH; pfam01368
546342000073	DHHA1 domain; Region: DHHA1; pfam02272
546342000074	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
546342000075	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
546342000076	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
546342000077	replicative DNA helicase; Region: DnaB; TIGR00665
546342000078	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
546342000079	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
546342000080	Walker A motif; other site
546342000081	ATP binding site [chemical binding]; other site
546342000082	Walker B motif; other site
546342000083	DNA binding loops [nucleotide binding]
546342000084	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
546342000085	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
546342000086	GDP-binding site [chemical binding]; other site
546342000087	ACT binding site; other site
546342000088	IMP binding site; other site
546342000089	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546342000090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342000091	active site
546342000092	phosphorylation site [posttranslational modification]
546342000093	intermolecular recognition site; other site
546342000094	dimerization interface [polypeptide binding]; other site
546342000095	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546342000096	DNA binding site [nucleotide binding]
546342000097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
546342000098	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546342000099	dimerization interface [polypeptide binding]; other site
546342000100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
546342000101	putative active site [active]
546342000102	heme pocket [chemical binding]; other site
546342000103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546342000104	dimer interface [polypeptide binding]; other site
546342000105	phosphorylation site [posttranslational modification]
546342000106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342000107	ATP binding site [chemical binding]; other site
546342000108	Mg2+ binding site [ion binding]; other site
546342000109	G-X-G motif; other site
546342000110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
546342000111	YycH protein; Region: YycH; pfam07435
546342000112	YycH protein; Region: YycI; cl02015
546342000113	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
546342000114	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
546342000115	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
546342000116	putative active site [active]
546342000117	putative metal binding site [ion binding]; other site
546342000118	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
546342000119	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
546342000120	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
546342000121	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
546342000122	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
546342000123	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
546342000124	Integrase core domain; Region: rve; pfam00665
546342000125	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
546342000126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
546342000127	Integrase core domain; Region: rve; pfam00665
546342000128	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
546342000129	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
546342000130	dimer interface [polypeptide binding]; other site
546342000131	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546342000132	ligand binding site [chemical binding]; other site
546342000133	Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cd05397
546342000134	metal binding triad [ion binding]; metal-binding site
546342000135	KNTase C-terminal domain; Region: KNTase_C; pfam07827
546342000136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
546342000137	Integrase core domain; Region: rve; pfam00665
546342000138	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
546342000139	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
546342000140	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
546342000141	putative active site [active]
546342000142	catalytic site [active]
546342000143	putative metal binding site [ion binding]; other site
546342000144	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
546342000145	putative active site [active]
546342000146	putative catalytic site [active]
546342000147	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
546342000148	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
546342000149	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
546342000150	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546342000151	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
546342000152	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
546342000153	Predicted transcriptional regulator [Transcription]; Region: COG3682
546342000154	MarR family; Region: MarR_2; pfam12802
546342000155	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
546342000156	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
546342000157	nucleotide binding site [chemical binding]; other site
546342000158	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
546342000159	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
546342000160	active site residue [active]
546342000161	SirA_RHOD_Pry_redox.    SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420
546342000162	CPxP  motif; other site
546342000163	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
546342000164	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
546342000165	putative homodimer interface [polypeptide binding]; other site
546342000166	putative homotetramer interface [polypeptide binding]; other site
546342000167	putative metal binding site [ion binding]; other site
546342000168	putative homodimer-homodimer interface [polypeptide binding]; other site
546342000169	putative allosteric switch controlling residues; other site
546342000170	cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779
546342000171	Cadmium resistance transporter; Region: Cad; pfam03596
546342000172	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546342000173	metal-binding site [ion binding]
546342000174	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546342000175	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
546342000176	metal-binding site [ion binding]
546342000177	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
546342000178	Soluble P-type ATPase [General function prediction only]; Region: COG4087
546342000179	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546342000180	dimerization interface [polypeptide binding]; other site
546342000181	putative DNA binding site [nucleotide binding]; other site
546342000182	putative Zn2+ binding site [ion binding]; other site
546342000183	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
546342000184	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
546342000185	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
546342000186	active site
546342000187	DNA binding site [nucleotide binding]
546342000188	Int/Topo IB signature motif; other site
546342000189	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
546342000190	MPN+ (JAMM) motif; other site
546342000191	Zinc-binding site [ion binding]; other site
546342000192	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
546342000193	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
546342000194	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
546342000195	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
546342000196	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
546342000197	catalytic residues [active]
546342000198	catalytic nucleophile [active]
546342000199	Presynaptic Site I dimer interface [polypeptide binding]; other site
546342000200	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
546342000201	Synaptic Flat tetramer interface [polypeptide binding]; other site
546342000202	Synaptic Site I dimer interface [polypeptide binding]; other site
546342000203	DNA binding site [nucleotide binding]
546342000204	Recombinase; Region: Recombinase; pfam07508
546342000205	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
546342000206	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
546342000207	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
546342000208	catalytic residues [active]
546342000209	catalytic nucleophile [active]
546342000210	Recombinase; Region: Recombinase; pfam07508
546342000211	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
546342000212	Domain of unknown function (DUF927); Region: DUF927; pfam06048
546342000213	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
546342000214	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
546342000215	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342000216	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
546342000217	Walker A motif; other site
546342000218	ATP binding site [chemical binding]; other site
546342000219	Walker B motif; other site
546342000220	arginine finger; other site
546342000221	5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736
546342000222	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
546342000223	active site
546342000224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342000225	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342000226	putative substrate translocation pore; other site
546342000227	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546342000228	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546342000229	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342000230	Coenzyme A binding pocket [chemical binding]; other site
546342000231	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
546342000232	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
546342000233	FMN binding site [chemical binding]; other site
546342000234	active site
546342000235	catalytic residues [active]
546342000236	substrate binding site [chemical binding]; other site
546342000237	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
546342000238	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
546342000239	Part of AAA domain; Region: AAA_19; pfam13245
546342000240	AAA domain; Region: AAA_12; pfam13087
546342000241	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
546342000242	active site
546342000243	catalytic site [active]
546342000244	putative metal binding site [ion binding]; other site
546342000245	Protein of unknown function, DUF576; Region: DUF576; pfam04507
546342000246	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
546342000247	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
546342000248	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
546342000249	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
546342000250	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
546342000251	metal binding site [ion binding]; metal-binding site
546342000252	dimer interface [polypeptide binding]; other site
546342000253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342000254	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342000255	putative substrate translocation pore; other site
546342000256	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342000257	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
546342000258	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
546342000259	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
546342000260	PhoU domain; Region: PhoU; pfam01895
546342000261	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
546342000262	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
546342000263	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
546342000264	L-lactate permease; Region: Lactate_perm; cl00701
546342000265	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
546342000266	B domain; Region: B; pfam02216
546342000267	B domain; Region: B; pfam02216
546342000268	B domain; Region: B; pfam02216
546342000269	B domain; Region: B; pfam02216
546342000270	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
546342000271	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546342000272	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342000273	Transcriptional regulators [Transcription]; Region: MarR; COG1846
546342000274	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342000275	Transcriptional regulators [Transcription]; Region: MarR; COG1846
546342000276	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546342000277	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342000278	ABC-ATPase subunit  interface; other site
546342000279	dimer interface [polypeptide binding]; other site
546342000280	putative PBP binding regions; other site
546342000281	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546342000282	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342000283	ABC-ATPase subunit  interface; other site
546342000284	dimer interface [polypeptide binding]; other site
546342000285	putative PBP binding regions; other site
546342000286	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
546342000287	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546342000288	siderophore binding site; other site
546342000289	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
546342000290	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
546342000291	dimer interface [polypeptide binding]; other site
546342000292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342000293	catalytic residue [active]
546342000294	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
546342000295	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
546342000296	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
546342000297	IucA / IucC family; Region: IucA_IucC; pfam04183
546342000298	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
546342000299	drug efflux system protein MdtG; Provisional; Region: PRK09874
546342000300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342000301	putative substrate translocation pore; other site
546342000302	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
546342000303	IucA / IucC family; Region: IucA_IucC; pfam04183
546342000304	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
546342000305	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
546342000306	IucA / IucC family; Region: IucA_IucC; pfam04183
546342000307	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
546342000308	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
546342000309	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
546342000310	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
546342000311	dimer interface [polypeptide binding]; other site
546342000312	active site
546342000313	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546342000314	catalytic residues [active]
546342000315	substrate binding site [chemical binding]; other site
546342000316	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
546342000317	ParB-like nuclease domain; Region: ParBc; pfam02195
546342000318	acetoin reductase; Validated; Region: PRK08643
546342000319	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
546342000320	NAD binding site [chemical binding]; other site
546342000321	homotetramer interface [polypeptide binding]; other site
546342000322	homodimer interface [polypeptide binding]; other site
546342000323	active site
546342000324	substrate binding site [chemical binding]; other site
546342000325	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546342000326	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
546342000327	NAD(P) binding site [chemical binding]; other site
546342000328	active site
546342000329	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
546342000330	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
546342000331	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546342000332	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
546342000333	putative ADP-binding pocket [chemical binding]; other site
546342000334	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
546342000335	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
546342000336	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
546342000337	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
546342000338	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
546342000339	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
546342000340	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546342000341	DNA-binding site [nucleotide binding]; DNA binding site
546342000342	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
546342000343	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
546342000344	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342000345	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
546342000346	intersubunit interface [polypeptide binding]; other site
546342000347	active site
546342000348	catalytic residue [active]
546342000349	phosphopentomutase; Provisional; Region: PRK05362
546342000350	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
546342000351	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
546342000352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342000353	dimer interface [polypeptide binding]; other site
546342000354	conserved gate region; other site
546342000355	putative PBP binding loops; other site
546342000356	ABC-ATPase subunit interface; other site
546342000357	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
546342000358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342000359	dimer interface [polypeptide binding]; other site
546342000360	conserved gate region; other site
546342000361	ABC-ATPase subunit interface; other site
546342000362	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
546342000363	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
546342000364	Walker A/P-loop; other site
546342000365	ATP binding site [chemical binding]; other site
546342000366	Q-loop/lid; other site
546342000367	ABC transporter signature motif; other site
546342000368	Walker B; other site
546342000369	D-loop; other site
546342000370	H-loop/switch region; other site
546342000371	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
546342000372	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
546342000373	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
546342000374	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
546342000375	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
546342000376	active site
546342000377	metal binding site [ion binding]; metal-binding site
546342000378	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
546342000379	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546342000380	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342000381	non-specific DNA binding site [nucleotide binding]; other site
546342000382	salt bridge; other site
546342000383	sequence-specific DNA binding site [nucleotide binding]; other site
546342000384	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
546342000385	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
546342000386	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
546342000387	putative catalytic cysteine [active]
546342000388	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
546342000389	putative active site [active]
546342000390	metal binding site [ion binding]; metal-binding site
546342000391	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
546342000392	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
546342000393	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
546342000394	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546342000395	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
546342000396	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
546342000397	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
546342000398	NAD(P) binding site [chemical binding]; other site
546342000399	homodimer interface [polypeptide binding]; other site
546342000400	substrate binding site [chemical binding]; other site
546342000401	active site
546342000402	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
546342000403	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
546342000404	NAD(P) binding site [chemical binding]; other site
546342000405	homodimer interface [polypeptide binding]; other site
546342000406	substrate binding site [chemical binding]; other site
546342000407	active site
546342000408	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
546342000409	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
546342000410	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
546342000411	putative NAD(P) binding site [chemical binding]; other site
546342000412	active site
546342000413	putative substrate binding site [chemical binding]; other site
546342000414	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
546342000415	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
546342000416	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
546342000417	active site
546342000418	homodimer interface [polypeptide binding]; other site
546342000419	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546342000420	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546342000421	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
546342000422	trimer interface [polypeptide binding]; other site
546342000423	active site
546342000424	substrate binding site [chemical binding]; other site
546342000425	CoA binding site [chemical binding]; other site
546342000426	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
546342000427	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546342000428	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
546342000429	Bacterial sugar transferase; Region: Bac_transf; pfam02397
546342000430	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
546342000431	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
546342000432	putative NAD(P) binding site [chemical binding]; other site
546342000433	active site
546342000434	putative substrate binding site [chemical binding]; other site
546342000435	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
546342000436	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
546342000437	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
546342000438	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
546342000439	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
546342000440	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
546342000441	active site
546342000442	homodimer interface [polypeptide binding]; other site
546342000443	heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313
546342000444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
546342000445	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
546342000446	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
546342000447	NAD(P) binding site [chemical binding]; other site
546342000448	catalytic residues [active]
546342000449	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
546342000450	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
546342000451	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
546342000452	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
546342000453	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
546342000454	Walker A/P-loop; other site
546342000455	ATP binding site [chemical binding]; other site
546342000456	Q-loop/lid; other site
546342000457	ABC transporter signature motif; other site
546342000458	Walker B; other site
546342000459	D-loop; other site
546342000460	H-loop/switch region; other site
546342000461	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
546342000462	NMT1-like family; Region: NMT1_2; pfam13379
546342000463	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
546342000464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
546342000465	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
546342000466	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
546342000467	Uncharacterized conserved protein [Function unknown]; Region: COG5609
546342000468	formate dehydrogenase; Provisional; Region: PRK07574
546342000469	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
546342000470	dimerization interface [polypeptide binding]; other site
546342000471	ligand binding site [chemical binding]; other site
546342000472	NAD binding site [chemical binding]; other site
546342000473	catalytic site [active]
546342000474	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
546342000475	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
546342000476	acyl-activating enzyme (AAE) consensus motif; other site
546342000477	AMP binding site [chemical binding]; other site
546342000478	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
546342000479	Condensation domain; Region: Condensation; pfam00668
546342000480	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
546342000481	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
546342000482	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
546342000483	acyl-activating enzyme (AAE) consensus motif; other site
546342000484	AMP binding site [chemical binding]; other site
546342000485	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
546342000486	thioester reductase domain; Region: Thioester-redct; TIGR01746
546342000487	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546342000488	NAD(P) binding site [chemical binding]; other site
546342000489	active site
546342000490	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
546342000491	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
546342000492	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
546342000493	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
546342000494	nucleotide binding site [chemical binding]; other site
546342000495	N-acetyl-L-glutamate binding site [chemical binding]; other site
546342000496	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
546342000497	heterotetramer interface [polypeptide binding]; other site
546342000498	active site pocket [active]
546342000499	cleavage site
546342000500	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
546342000501	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
546342000502	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
546342000503	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546342000504	inhibitor-cofactor binding pocket; inhibition site
546342000505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342000506	catalytic residue [active]
546342000507	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
546342000508	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
546342000509	Isochorismatase family; Region: Isochorismatase; pfam00857
546342000510	catalytic triad [active]
546342000511	conserved cis-peptide bond; other site
546342000512	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
546342000513	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
546342000514	dimer interface [polypeptide binding]; other site
546342000515	PYR/PP interface [polypeptide binding]; other site
546342000516	TPP binding site [chemical binding]; other site
546342000517	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
546342000518	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
546342000519	TPP-binding site [chemical binding]; other site
546342000520	dimer interface [polypeptide binding]; other site
546342000521	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
546342000522	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
546342000523	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
546342000524	active site turn [active]
546342000525	phosphorylation site [posttranslational modification]
546342000526	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
546342000527	HPr interaction site; other site
546342000528	glycerol kinase (GK) interaction site [polypeptide binding]; other site
546342000529	active site
546342000530	phosphorylation site [posttranslational modification]
546342000531	Uncharacterized conserved protein [Function unknown]; Region: COG3589
546342000532	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
546342000533	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
546342000534	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
546342000535	putative active site [active]
546342000536	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
546342000537	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
546342000538	active site turn [active]
546342000539	phosphorylation site [posttranslational modification]
546342000540	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
546342000541	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
546342000542	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
546342000543	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
546342000544	putative active site [active]
546342000545	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
546342000546	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
546342000547	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546342000548	ATP binding site [chemical binding]; other site
546342000549	putative Mg++ binding site [ion binding]; other site
546342000550	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
546342000551	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546342000552	Walker A/P-loop; other site
546342000553	ATP binding site [chemical binding]; other site
546342000554	Q-loop/lid; other site
546342000555	ABC transporter signature motif; other site
546342000556	Walker B; other site
546342000557	D-loop; other site
546342000558	H-loop/switch region; other site
546342000559	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
546342000560	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546342000561	Walker A/P-loop; other site
546342000562	ATP binding site [chemical binding]; other site
546342000563	Q-loop/lid; other site
546342000564	ABC transporter signature motif; other site
546342000565	Walker B; other site
546342000566	D-loop; other site
546342000567	H-loop/switch region; other site
546342000568	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546342000569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342000570	dimer interface [polypeptide binding]; other site
546342000571	conserved gate region; other site
546342000572	putative PBP binding loops; other site
546342000573	ABC-ATPase subunit interface; other site
546342000574	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546342000575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342000576	dimer interface [polypeptide binding]; other site
546342000577	conserved gate region; other site
546342000578	ABC-ATPase subunit interface; other site
546342000579	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
546342000580	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
546342000581	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
546342000582	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
546342000583	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
546342000584	azoreductase; Reviewed; Region: PRK00170
546342000585	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
546342000586	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546342000587	Peptidase family M23; Region: Peptidase_M23; pfam01551
546342000588	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
546342000589	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
546342000590	Walker A/P-loop; other site
546342000591	ATP binding site [chemical binding]; other site
546342000592	Q-loop/lid; other site
546342000593	ABC transporter signature motif; other site
546342000594	Walker B; other site
546342000595	D-loop; other site
546342000596	H-loop/switch region; other site
546342000597	TOBE domain; Region: TOBE; pfam03459
546342000598	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
546342000599	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
546342000600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342000601	dimer interface [polypeptide binding]; other site
546342000602	conserved gate region; other site
546342000603	ABC-ATPase subunit interface; other site
546342000604	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
546342000605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342000606	dimer interface [polypeptide binding]; other site
546342000607	conserved gate region; other site
546342000608	putative PBP binding loops; other site
546342000609	ABC-ATPase subunit interface; other site
546342000610	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
546342000611	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
546342000612	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
546342000613	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
546342000614	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
546342000615	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
546342000616	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
546342000617	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
546342000618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
546342000619	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
546342000620	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342000621	putative substrate translocation pore; other site
546342000622	Response regulator receiver domain; Region: Response_reg; pfam00072
546342000623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342000624	active site
546342000625	phosphorylation site [posttranslational modification]
546342000626	intermolecular recognition site; other site
546342000627	dimerization interface [polypeptide binding]; other site
546342000628	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
546342000629	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
546342000630	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
546342000631	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
546342000632	Histidine kinase; Region: His_kinase; pfam06580
546342000633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342000634	ATP binding site [chemical binding]; other site
546342000635	Mg2+ binding site [ion binding]; other site
546342000636	G-X-G motif; other site
546342000637	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
546342000638	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
546342000639	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
546342000640	Pyruvate formate lyase 1; Region: PFL1; cd01678
546342000641	coenzyme A binding site [chemical binding]; other site
546342000642	active site
546342000643	catalytic residues [active]
546342000644	glycine loop; other site
546342000645	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
546342000646	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546342000647	FeS/SAM binding site; other site
546342000648	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
546342000649	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
546342000650	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
546342000651	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
546342000652	putative active site [active]
546342000653	catalytic site [active]
546342000654	putative metal binding site [ion binding]; other site
546342000655	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
546342000656	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
546342000657	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
546342000658	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
546342000659	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
546342000660	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
546342000661	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
546342000662	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
546342000663	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
546342000664	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
546342000665	dimer interface [polypeptide binding]; other site
546342000666	active site
546342000667	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
546342000668	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
546342000669	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
546342000670	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
546342000671	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
546342000672	substrate binding site [chemical binding]; other site
546342000673	oxyanion hole (OAH) forming residues; other site
546342000674	trimer interface [polypeptide binding]; other site
546342000675	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
546342000676	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
546342000677	active site
546342000678	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
546342000679	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
546342000680	acyl-activating enzyme (AAE) consensus motif; other site
546342000681	AMP binding site [chemical binding]; other site
546342000682	active site
546342000683	CoA binding site [chemical binding]; other site
546342000684	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
546342000685	Coenzyme A transferase; Region: CoA_trans; smart00882
546342000686	Coenzyme A transferase; Region: CoA_trans; cl17247
546342000687	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
546342000688	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
546342000689	catalytic triad [active]
546342000690	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
546342000691	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
546342000692	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
546342000693	Uncharacterized conserved protein [Function unknown]; Region: COG3189
546342000694	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
546342000695	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
546342000696	heme-binding site [chemical binding]; other site
546342000697	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
546342000698	FAD binding pocket [chemical binding]; other site
546342000699	FAD binding motif [chemical binding]; other site
546342000700	phosphate binding motif [ion binding]; other site
546342000701	beta-alpha-beta structure motif; other site
546342000702	NAD binding pocket [chemical binding]; other site
546342000703	Heme binding  pocket [chemical binding]; other site
546342000704	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
546342000705	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
546342000706	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546342000707	NAD binding site [chemical binding]; other site
546342000708	dimer interface [polypeptide binding]; other site
546342000709	substrate binding site [chemical binding]; other site
546342000710	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
546342000711	active site
546342000712	tetramer interface [polypeptide binding]; other site
546342000713	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
546342000714	Mga helix-turn-helix domain; Region: Mga; pfam05043
546342000715	PRD domain; Region: PRD; pfam00874
546342000716	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
546342000717	active site
546342000718	P-loop; other site
546342000719	phosphorylation site [posttranslational modification]
546342000720	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
546342000721	active site
546342000722	phosphorylation site [posttranslational modification]
546342000723	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
546342000724	active site
546342000725	phosphorylation site [posttranslational modification]
546342000726	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
546342000727	active site
546342000728	P-loop; other site
546342000729	phosphorylation site [posttranslational modification]
546342000730	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
546342000731	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
546342000732	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
546342000733	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
546342000734	putative NAD(P) binding site [chemical binding]; other site
546342000735	catalytic Zn binding site [ion binding]; other site
546342000736	structural Zn binding site [ion binding]; other site
546342000737	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
546342000738	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
546342000739	putative NAD(P) binding site [chemical binding]; other site
546342000740	catalytic Zn binding site [ion binding]; other site
546342000741	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
546342000742	substrate binding site; other site
546342000743	dimer interface; other site
546342000744	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
546342000745	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
546342000746	putative NAD(P) binding site [chemical binding]; other site
546342000747	putative catalytic Zn binding site [ion binding]; other site
546342000748	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
546342000749	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
546342000750	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
546342000751	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
546342000752	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
546342000753	substrate binding site; other site
546342000754	dimer interface; other site
546342000755	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
546342000756	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
546342000757	putative NAD(P) binding site [chemical binding]; other site
546342000758	putative catalytic Zn binding site [ion binding]; other site
546342000759	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
546342000760	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
546342000761	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546342000762	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546342000763	active site
546342000764	cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
546342000765	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
546342000766	Hemerythrin-like domain; Region: Hr-like; cd12108
546342000767	Fe binding site [ion binding]; other site
546342000768	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
546342000769	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
546342000770	Histidine kinase; Region: His_kinase; pfam06580
546342000771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342000772	Mg2+ binding site [ion binding]; other site
546342000773	G-X-G motif; other site
546342000774	two-component response regulator; Provisional; Region: PRK14084
546342000775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342000776	active site
546342000777	phosphorylation site [posttranslational modification]
546342000778	intermolecular recognition site; other site
546342000779	dimerization interface [polypeptide binding]; other site
546342000780	LytTr DNA-binding domain; Region: LytTR; pfam04397
546342000781	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
546342000782	antiholin-like protein LrgB; Provisional; Region: PRK04288
546342000783	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
546342000784	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
546342000785	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
546342000786	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546342000787	DNA-binding site [nucleotide binding]; DNA binding site
546342000788	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
546342000789	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
546342000790	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
546342000791	HPr interaction site; other site
546342000792	glycerol kinase (GK) interaction site [polypeptide binding]; other site
546342000793	active site
546342000794	phosphorylation site [posttranslational modification]
546342000795	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
546342000796	beta-galactosidase; Region: BGL; TIGR03356
546342000797	Methyltransferase domain; Region: Methyltransf_31; pfam13847
546342000798	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342000799	S-adenosylmethionine binding site [chemical binding]; other site
546342000800	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546342000801	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
546342000802	substrate binding site [chemical binding]; other site
546342000803	dimer interface [polypeptide binding]; other site
546342000804	ATP binding site [chemical binding]; other site
546342000805	D-ribose pyranase; Provisional; Region: PRK11797
546342000806	Sugar transport protein; Region: Sugar_transport; pfam06800
546342000807	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546342000808	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546342000809	DNA binding site [nucleotide binding]
546342000810	domain linker motif; other site
546342000811	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
546342000812	dimerization interface [polypeptide binding]; other site
546342000813	ligand binding site [chemical binding]; other site
546342000814	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342000815	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342000816	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
546342000817	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
546342000818	active site
546342000819	Surface antigen [General function prediction only]; Region: COG3942
546342000820	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546342000821	Peptidase family M23; Region: Peptidase_M23; pfam01551
546342000822	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
546342000823	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
546342000824	Walker A/P-loop; other site
546342000825	ATP binding site [chemical binding]; other site
546342000826	Q-loop/lid; other site
546342000827	ABC transporter signature motif; other site
546342000828	Walker B; other site
546342000829	D-loop; other site
546342000830	H-loop/switch region; other site
546342000831	Surface antigen [General function prediction only]; Region: COG3942
546342000832	CHAP domain; Region: CHAP; pfam05257
546342000833	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
546342000834	Predicted membrane protein [Function unknown]; Region: COG1511
546342000835	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
546342000836	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
546342000837	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
546342000838	Uncharacterized small protein [Function unknown]; Region: COG5417
546342000839	Predicted membrane protein [Function unknown]; Region: COG4499
546342000840	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
546342000841	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
546342000842	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
546342000843	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
546342000844	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
546342000845	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
546342000846	LXG domain of WXG superfamily; Region: LXG; pfam04740
546342000847	Protein of unknown function, DUF600; Region: DUF600; cl04640
546342000848	Protein of unknown function, DUF600; Region: DUF600; cl04640
546342000849	Protein of unknown function, DUF600; Region: DUF600; cl04640
546342000850	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
546342000851	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
546342000852	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
546342000853	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
546342000854	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
546342000855	FtsX-like permease family; Region: FtsX; pfam02687
546342000856	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546342000857	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546342000858	Walker A/P-loop; other site
546342000859	ATP binding site [chemical binding]; other site
546342000860	Q-loop/lid; other site
546342000861	ABC transporter signature motif; other site
546342000862	Walker B; other site
546342000863	D-loop; other site
546342000864	H-loop/switch region; other site
546342000865	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
546342000866	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
546342000867	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342000868	non-specific DNA binding site [nucleotide binding]; other site
546342000869	salt bridge; other site
546342000870	sequence-specific DNA binding site [nucleotide binding]; other site
546342000871	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546342000872	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
546342000873	substrate binding site [chemical binding]; other site
546342000874	ATP binding site [chemical binding]; other site
546342000875	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
546342000876	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
546342000877	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
546342000878	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
546342000879	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
546342000880	putative transporter; Provisional; Region: PRK10484
546342000881	Na binding site [ion binding]; other site
546342000882	N-acetylneuraminate lyase; Provisional; Region: PRK04147
546342000883	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
546342000884	inhibitor site; inhibition site
546342000885	active site
546342000886	dimer interface [polypeptide binding]; other site
546342000887	catalytic residue [active]
546342000888	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
546342000889	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
546342000890	nucleotide binding site [chemical binding]; other site
546342000891	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
546342000892	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
546342000893	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
546342000894	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
546342000895	putative active site [active]
546342000896	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
546342000897	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
546342000898	putative active site cavity [active]
546342000899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
546342000900	Nucleoside recognition; Region: Gate; pfam07670
546342000901	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342000902	MULE transposase domain; Region: MULE; pfam10551
546342000903	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
546342000904	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
546342000905	PGAP1-like protein; Region: PGAP1; pfam07819
546342000906	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
546342000907	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
546342000908	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
546342000909	putative active site [active]
546342000910	putative FMN binding site [chemical binding]; other site
546342000911	putative substrate binding site [chemical binding]; other site
546342000912	putative catalytic residue [active]
546342000913	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
546342000914	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
546342000915	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
546342000916	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
546342000917	lipoyl attachment site [posttranslational modification]; other site
546342000918	Replication protein C N-terminal domain; Region: RP-C; pfam03428
546342000919	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
546342000920	putative ADP-ribose binding site [chemical binding]; other site
546342000921	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
546342000922	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
546342000923	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
546342000924	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
546342000925	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
546342000926	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546342000927	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
546342000928	NADP binding site [chemical binding]; other site
546342000929	putative substrate binding site [chemical binding]; other site
546342000930	active site
546342000931	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
546342000932	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
546342000933	active site
546342000934	P-loop; other site
546342000935	phosphorylation site [posttranslational modification]
546342000936	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
546342000937	active site
546342000938	phosphorylation site [posttranslational modification]
546342000939	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
546342000940	HTH domain; Region: HTH_11; pfam08279
546342000941	HTH domain; Region: HTH_11; pfam08279
546342000942	PRD domain; Region: PRD; pfam00874
546342000943	PRD domain; Region: PRD; pfam00874
546342000944	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
546342000945	active site
546342000946	P-loop; other site
546342000947	phosphorylation site [posttranslational modification]
546342000948	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
546342000949	active site
546342000950	phosphorylation site [posttranslational modification]
546342000951	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546342000952	MarR family; Region: MarR_2; pfam12802
546342000953	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
546342000954	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
546342000955	MepB protein; Region: MepB; cl01985
546342000956	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
546342000957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342000958	putative substrate translocation pore; other site
546342000959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342000960	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546342000961	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
546342000962	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
546342000963	Zn binding site [ion binding]; other site
546342000964	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
546342000965	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
546342000966	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
546342000967	Predicted flavoprotein [General function prediction only]; Region: COG0431
546342000968	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
546342000969	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
546342000970	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546342000971	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546342000972	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
546342000973	Imelysin; Region: Peptidase_M75; pfam09375
546342000974	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
546342000975	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
546342000976	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
546342000977	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
546342000978	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
546342000979	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
546342000980	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342000981	non-specific DNA binding site [nucleotide binding]; other site
546342000982	salt bridge; other site
546342000983	sequence-specific DNA binding site [nucleotide binding]; other site
546342000984	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
546342000985	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
546342000986	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
546342000987	Walker A/P-loop; other site
546342000988	ATP binding site [chemical binding]; other site
546342000989	Q-loop/lid; other site
546342000990	ABC transporter signature motif; other site
546342000991	Walker B; other site
546342000992	D-loop; other site
546342000993	H-loop/switch region; other site
546342000994	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
546342000995	Predicted membrane protein [Function unknown]; Region: COG4292
546342000996	putative acyltransferase; Provisional; Region: PRK05790
546342000997	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
546342000998	dimer interface [polypeptide binding]; other site
546342000999	active site
546342001000	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
546342001001	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
546342001002	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
546342001003	THF binding site; other site
546342001004	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
546342001005	substrate binding site [chemical binding]; other site
546342001006	THF binding site; other site
546342001007	zinc-binding site [ion binding]; other site
546342001008	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
546342001009	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
546342001010	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
546342001011	FAD binding site [chemical binding]; other site
546342001012	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
546342001013	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
546342001014	homodimer interface [polypeptide binding]; other site
546342001015	substrate-cofactor binding pocket; other site
546342001016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342001017	catalytic residue [active]
546342001018	cystathionine gamma-synthase; Reviewed; Region: PRK08247
546342001019	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546342001020	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546342001021	catalytic residue [active]
546342001022	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
546342001023	ParB-like nuclease domain; Region: ParB; smart00470
546342001024	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
546342001025	Mechanosensitive ion channel; Region: MS_channel; pfam00924
546342001026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
546342001027	GTP-binding protein YchF; Reviewed; Region: PRK09601
546342001028	YchF GTPase; Region: YchF; cd01900
546342001029	G1 box; other site
546342001030	GTP/Mg2+ binding site [chemical binding]; other site
546342001031	Switch I region; other site
546342001032	G2 box; other site
546342001033	Switch II region; other site
546342001034	G3 box; other site
546342001035	G4 box; other site
546342001036	G5 box; other site
546342001037	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
546342001038	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
546342001039	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
546342001040	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
546342001041	dimer interface [polypeptide binding]; other site
546342001042	ssDNA binding site [nucleotide binding]; other site
546342001043	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546342001044	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
546342001045	PemK-like protein; Region: PemK; pfam02452
546342001046	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
546342001047	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
546342001048	Int/Topo IB signature motif; other site
546342001049	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546342001050	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342001051	non-specific DNA binding site [nucleotide binding]; other site
546342001052	salt bridge; other site
546342001053	sequence-specific DNA binding site [nucleotide binding]; other site
546342001054	Helix-turn-helix domain; Region: HTH_17; cl17695
546342001055	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
546342001056	Protein of unknown function (DUF1474); Region: DUF1474; pfam07342
546342001057	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
546342001058	D5 N terminal like; Region: D5_N; smart00885
546342001059	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
546342001060	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
546342001061	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
546342001062	Abi-like protein; Region: Abi_2; pfam07751
546342001063	Abi-like protein; Region: Abi_2; pfam07751
546342001064	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
546342001066	Predicted membrane protein [Function unknown]; Region: COG3212
546342001067	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
546342001068	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
546342001069	non-specific DNA binding site [nucleotide binding]; other site
546342001070	salt bridge; other site
546342001071	sequence-specific DNA binding site [nucleotide binding]; other site
546342001072	Predicted membrane protein [Function unknown]; Region: COG2261
546342001073	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546342001074	catalytic core [active]
546342001075	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
546342001076	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
546342001077	catalytic residue [active]
546342001078	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
546342001079	catalytic residues [active]
546342001080	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546342001081	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342001082	peroxiredoxin; Region: AhpC; TIGR03137
546342001083	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
546342001084	dimer interface [polypeptide binding]; other site
546342001085	decamer (pentamer of dimers) interface [polypeptide binding]; other site
546342001086	catalytic triad [active]
546342001087	peroxidatic and resolving cysteines [active]
546342001088	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
546342001089	dimer interface [polypeptide binding]; other site
546342001090	FMN binding site [chemical binding]; other site
546342001091	NADPH bind site [chemical binding]; other site
546342001092	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
546342001093	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
546342001094	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546342001095	active site
546342001096	xanthine permease; Region: pbuX; TIGR03173
546342001097	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
546342001098	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
546342001099	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
546342001100	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
546342001101	active site
546342001102	GMP synthase; Reviewed; Region: guaA; PRK00074
546342001103	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
546342001104	AMP/PPi binding site [chemical binding]; other site
546342001105	candidate oxyanion hole; other site
546342001106	catalytic triad [active]
546342001107	potential glutamine specificity residues [chemical binding]; other site
546342001108	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
546342001109	ATP Binding subdomain [chemical binding]; other site
546342001110	Ligand Binding sites [chemical binding]; other site
546342001111	Dimerization subdomain; other site
546342001112	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
546342001113	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
546342001114	Int/Topo IB signature motif; other site
546342001115	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
546342001116	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546342001117	DNA binding residues [nucleotide binding]
546342001118	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546342001119	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342001120	non-specific DNA binding site [nucleotide binding]; other site
546342001121	salt bridge; other site
546342001122	sequence-specific DNA binding site [nucleotide binding]; other site
546342001123	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
546342001124	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
546342001125	G1 box; other site
546342001126	putative GEF interaction site [polypeptide binding]; other site
546342001127	GTP/Mg2+ binding site [chemical binding]; other site
546342001128	Switch I region; other site
546342001129	G2 box; other site
546342001130	G3 box; other site
546342001131	Switch II region; other site
546342001132	G4 box; other site
546342001133	G5 box; other site
546342001134	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
546342001135	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
546342001136	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
546342001137	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
546342001138	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
546342001139	N-acetyl-D-glucosamine binding site [chemical binding]; other site
546342001140	catalytic residue [active]
546342001141	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
546342001142	NlpC/P60 family; Region: NLPC_P60; pfam00877
546342001143	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
546342001144	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342001145	AAA-like domain; Region: AAA_10; pfam12846
546342001146	TcpE family; Region: TcpE; pfam12648
546342001147	transposase/IS protein; Provisional; Region: PRK09183
546342001148	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342001149	Walker A motif; other site
546342001150	ATP binding site [chemical binding]; other site
546342001151	Walker B motif; other site
546342001152	arginine finger; other site
546342001153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
546342001154	Integrase core domain; Region: rve; pfam00665
546342001155	Antirestriction protein (ArdA); Region: ArdA; pfam07275
546342001156	Abortive infection C-terminus; Region: Abi_C; pfam14355
546342001157	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342001158	non-specific DNA binding site [nucleotide binding]; other site
546342001159	salt bridge; other site
546342001160	sequence-specific DNA binding site [nucleotide binding]; other site
546342001161	Replication initiation factor; Region: Rep_trans; pfam02486
546342001162	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
546342001163	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
546342001164	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
546342001165	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
546342001166	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
546342001167	Part of AAA domain; Region: AAA_19; pfam13245
546342001168	Family description; Region: UvrD_C_2; pfam13538
546342001169	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342001170	AAA domain; Region: AAA_21; pfam13304
546342001171	Walker A/P-loop; other site
546342001172	ATP binding site [chemical binding]; other site
546342001173	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
546342001174	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
546342001175	putative active site [active]
546342001176	putative metal-binding site [ion binding]; other site
546342001177	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342001178	MULE transposase domain; Region: MULE; pfam10551
546342001179	PemK-like protein; Region: PemK; pfam02452
546342001180	Predicted membrane protein [Function unknown]; Region: COG3759
546342001181	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
546342001182	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
546342001183	NADP binding site [chemical binding]; other site
546342001184	superantigen-like protein; Reviewed; Region: PRK13037
546342001185	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
546342001186	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001187	superantigen-like protein; Reviewed; Region: PRK13041
546342001188	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
546342001189	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001190	superantigen-like protein; Reviewed; Region: PRK13335
546342001191	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
546342001192	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001193	superantigen-like protein; Reviewed; Region: PRK13042
546342001194	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
546342001195	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001196	superantigen-like protein 5; Reviewed; Region: PRK13035
546342001197	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
546342001198	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001199	superantigen-like protein 7; Reviewed; Region: PRK13346
546342001200	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
546342001201	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001202	superantigen-like protein; Reviewed; Region: PRK13039
546342001203	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
546342001204	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001205	superantigen-like protein; Reviewed; Region: PRK13345
546342001206	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
546342001207	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001208	superantigen-like protein 5; Reviewed; Region: PRK13035
546342001209	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
546342001210	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001211	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
546342001212	HsdM N-terminal domain; Region: HsdM_N; pfam12161
546342001213	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342001214	S-adenosylmethionine binding site [chemical binding]; other site
546342001215	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
546342001216	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
546342001217	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
546342001218	superantigen-like protein; Reviewed; Region: PRK13036
546342001219	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
546342001220	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342001221	Protein of unknown function, DUF576; Region: DUF576; pfam04507
546342001222	Protein of unknown function, DUF576; Region: DUF576; cl04553
546342001223	Protein of unknown function, DUF576; Region: DUF576; pfam04507
546342001224	Protein of unknown function, DUF576; Region: DUF576; pfam04507
546342001225	Protein of unknown function, DUF576; Region: DUF576; pfam04507
546342001226	Protein of unknown function, DUF576; Region: DUF576; pfam04507
546342001227	Protein of unknown function, DUF576; Region: DUF576; pfam04507
546342001228	Protein of unknown function, DUF576; Region: DUF576; pfam04507
546342001229	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
546342001230	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
546342001231	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
546342001232	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
546342001233	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546342001234	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
546342001235	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
546342001236	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
546342001237	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
546342001238	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
546342001239	active site
546342001240	Esterase/lipase [General function prediction only]; Region: COG1647
546342001241	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546342001242	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
546342001243	Na2 binding site [ion binding]; other site
546342001244	putative substrate binding site 1 [chemical binding]; other site
546342001245	Na binding site 1 [ion binding]; other site
546342001246	putative substrate binding site 2 [chemical binding]; other site
546342001247	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
546342001248	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
546342001249	dimer interface [polypeptide binding]; other site
546342001250	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342001251	catalytic residue [active]
546342001252	cystathionine beta-lyase; Provisional; Region: PRK07671
546342001253	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
546342001254	homodimer interface [polypeptide binding]; other site
546342001255	substrate-cofactor binding pocket; other site
546342001256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342001257	catalytic residue [active]
546342001258	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342001259	dimer interface [polypeptide binding]; other site
546342001260	conserved gate region; other site
546342001261	ABC-ATPase subunit interface; other site
546342001262	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
546342001263	LysM domain; Region: LysM; pfam01476
546342001264	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546342001265	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546342001266	Surface antigen [General function prediction only]; Region: COG3942
546342001267	CHAP domain; Region: CHAP; pfam05257
546342001268	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
546342001269	nudix motif; other site
546342001270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342001271	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
546342001272	Coenzyme A binding pocket [chemical binding]; other site
546342001273	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
546342001274	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
546342001275	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546342001276	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546342001277	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
546342001278	dimerization interface [polypeptide binding]; other site
546342001279	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
546342001280	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
546342001281	active site
546342001282	dimer interface [polypeptide binding]; other site
546342001283	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
546342001284	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
546342001285	active site
546342001286	FMN binding site [chemical binding]; other site
546342001287	substrate binding site [chemical binding]; other site
546342001288	3Fe-4S cluster binding site [ion binding]; other site
546342001289	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
546342001290	domain interface; other site
546342001291	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
546342001292	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
546342001293	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
546342001294	Ca binding site [ion binding]; other site
546342001295	active site
546342001296	catalytic site [active]
546342001297	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
546342001298	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546342001299	DNA-binding site [nucleotide binding]; DNA binding site
546342001300	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
546342001301	UTRA domain; Region: UTRA; pfam07702
546342001302	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
546342001303	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342001304	Coenzyme A binding pocket [chemical binding]; other site
546342001305	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
546342001306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342001307	Walker A motif; other site
546342001308	ATP binding site [chemical binding]; other site
546342001309	Walker B motif; other site
546342001310	arginine finger; other site
546342001311	hypothetical protein; Validated; Region: PRK00153
546342001312	recombination protein RecR; Reviewed; Region: recR; PRK00076
546342001313	RecR protein; Region: RecR; pfam02132
546342001314	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
546342001315	putative active site [active]
546342001316	putative metal-binding site [ion binding]; other site
546342001317	tetramer interface [polypeptide binding]; other site
546342001318	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
546342001319	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546342001320	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546342001321	catalytic residue [active]
546342001322	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
546342001323	thymidylate kinase; Validated; Region: tmk; PRK00698
546342001324	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
546342001325	TMP-binding site; other site
546342001326	ATP-binding site [chemical binding]; other site
546342001327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
546342001328	DNA polymerase III subunit delta'; Validated; Region: PRK08058
546342001329	DNA polymerase III subunit delta'; Validated; Region: PRK08485
546342001330	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
546342001331	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
546342001332	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
546342001333	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342001334	S-adenosylmethionine binding site [chemical binding]; other site
546342001335	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
546342001336	GIY-YIG motif/motif A; other site
546342001337	putative active site [active]
546342001338	putative metal binding site [ion binding]; other site
546342001339	Predicted methyltransferases [General function prediction only]; Region: COG0313
546342001340	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
546342001341	putative SAM binding site [chemical binding]; other site
546342001342	putative homodimer interface [polypeptide binding]; other site
546342001343	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
546342001344	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
546342001345	active site
546342001346	HIGH motif; other site
546342001347	KMSKS motif; other site
546342001348	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
546342001349	tRNA binding surface [nucleotide binding]; other site
546342001350	anticodon binding site; other site
546342001351	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
546342001352	dimer interface [polypeptide binding]; other site
546342001353	putative tRNA-binding site [nucleotide binding]; other site
546342001354	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
546342001355	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
546342001356	active site
546342001357	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
546342001358	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
546342001359	putative active site [active]
546342001360	putative metal binding site [ion binding]; other site
546342001361	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
546342001362	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
546342001363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342001364	S-adenosylmethionine binding site [chemical binding]; other site
546342001365	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
546342001366	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
546342001367	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
546342001368	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
546342001369	pur operon repressor; Provisional; Region: PRK09213
546342001370	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
546342001371	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546342001372	active site
546342001373	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
546342001374	homotrimer interaction site [polypeptide binding]; other site
546342001375	putative active site [active]
546342001376	regulatory protein SpoVG; Reviewed; Region: PRK13259
546342001377	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
546342001378	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
546342001379	Substrate binding site; other site
546342001380	Mg++ binding site; other site
546342001381	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
546342001382	active site
546342001383	substrate binding site [chemical binding]; other site
546342001384	CoA binding site [chemical binding]; other site
546342001385	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
546342001386	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
546342001387	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546342001388	active site
546342001389	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
546342001390	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
546342001391	5S rRNA interface [nucleotide binding]; other site
546342001392	CTC domain interface [polypeptide binding]; other site
546342001393	L16 interface [polypeptide binding]; other site
546342001394	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
546342001395	putative active site [active]
546342001396	catalytic residue [active]
546342001397	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
546342001398	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
546342001399	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546342001400	ATP binding site [chemical binding]; other site
546342001401	putative Mg++ binding site [ion binding]; other site
546342001402	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546342001403	nucleotide binding region [chemical binding]; other site
546342001404	ATP-binding site [chemical binding]; other site
546342001405	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
546342001406	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
546342001407	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
546342001408	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
546342001409	putative SAM binding site [chemical binding]; other site
546342001410	putative homodimer interface [polypeptide binding]; other site
546342001411	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
546342001412	homodimer interface [polypeptide binding]; other site
546342001413	metal binding site [ion binding]; metal-binding site
546342001414	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546342001415	RNA binding surface [nucleotide binding]; other site
546342001416	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
546342001417	Septum formation initiator; Region: DivIC; pfam04977
546342001418	hypothetical protein; Provisional; Region: PRK08582
546342001419	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
546342001420	RNA binding site [nucleotide binding]; other site
546342001421	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
546342001422	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
546342001423	Ligand Binding Site [chemical binding]; other site
546342001424	TilS substrate C-terminal domain; Region: TilS_C; smart00977
546342001425	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
546342001426	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546342001427	active site
546342001428	FtsH Extracellular; Region: FtsH_ext; pfam06480
546342001429	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
546342001430	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342001431	Walker A motif; other site
546342001432	ATP binding site [chemical binding]; other site
546342001433	Walker B motif; other site
546342001434	arginine finger; other site
546342001435	Peptidase family M41; Region: Peptidase_M41; pfam01434
546342001436	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
546342001437	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
546342001438	dimerization interface [polypeptide binding]; other site
546342001439	domain crossover interface; other site
546342001440	redox-dependent activation switch; other site
546342001441	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
546342001442	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
546342001443	dimer interface [polypeptide binding]; other site
546342001444	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342001445	catalytic residue [active]
546342001446	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
546342001447	dihydropteroate synthase; Region: DHPS; TIGR01496
546342001448	substrate binding pocket [chemical binding]; other site
546342001449	dimer interface [polypeptide binding]; other site
546342001450	inhibitor binding site; inhibition site
546342001451	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
546342001452	homooctamer interface [polypeptide binding]; other site
546342001453	active site
546342001454	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
546342001455	catalytic center binding site [active]
546342001456	ATP binding site [chemical binding]; other site
546342001457	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
546342001458	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
546342001459	dimer interface [polypeptide binding]; other site
546342001460	putative anticodon binding site; other site
546342001461	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
546342001462	motif 1; other site
546342001463	active site
546342001464	motif 2; other site
546342001465	motif 3; other site
546342001466	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
546342001467	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546342001468	DNA-binding site [nucleotide binding]; DNA binding site
546342001469	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546342001470	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342001471	homodimer interface [polypeptide binding]; other site
546342001472	catalytic residue [active]
546342001473	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
546342001474	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
546342001475	active site
546342001476	multimer interface [polypeptide binding]; other site
546342001477	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
546342001478	predicted active site [active]
546342001479	catalytic triad [active]
546342001480	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
546342001481	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
546342001482	Nucleoside recognition; Region: Gate; pfam07670
546342001483	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
546342001484	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
546342001485	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
546342001486	UvrB/uvrC motif; Region: UVR; pfam02151
546342001487	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
546342001488	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
546342001489	ADP binding site [chemical binding]; other site
546342001490	phosphagen binding site; other site
546342001491	substrate specificity loop; other site
546342001492	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
546342001493	Clp amino terminal domain; Region: Clp_N; pfam02861
546342001494	Clp amino terminal domain; Region: Clp_N; pfam02861
546342001495	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342001496	Walker A motif; other site
546342001497	ATP binding site [chemical binding]; other site
546342001498	Walker B motif; other site
546342001499	arginine finger; other site
546342001500	UvrB/uvrC motif; Region: UVR; pfam02151
546342001501	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342001502	Walker A motif; other site
546342001503	ATP binding site [chemical binding]; other site
546342001504	Walker B motif; other site
546342001505	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
546342001506	DNA repair protein RadA; Provisional; Region: PRK11823
546342001507	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
546342001508	Walker A motif/ATP binding site; other site
546342001509	ATP binding site [chemical binding]; other site
546342001510	Walker B motif; other site
546342001511	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
546342001512	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
546342001513	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
546342001514	putative active site [active]
546342001515	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
546342001516	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
546342001517	active site
546342001518	HIGH motif; other site
546342001519	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
546342001520	active site
546342001521	KMSKS motif; other site
546342001522	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
546342001523	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
546342001524	trimer interface [polypeptide binding]; other site
546342001525	active site
546342001526	substrate binding site [chemical binding]; other site
546342001527	CoA binding site [chemical binding]; other site
546342001528	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
546342001529	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
546342001530	active site
546342001531	HIGH motif; other site
546342001532	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
546342001533	KMSKS motif; other site
546342001534	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
546342001535	tRNA binding surface [nucleotide binding]; other site
546342001536	anticodon binding site; other site
546342001537	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
546342001538	active site
546342001539	dimerization interface [polypeptide binding]; other site
546342001540	metal binding site [ion binding]; metal-binding site
546342001541	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
546342001542	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
546342001543	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
546342001544	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
546342001545	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
546342001546	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546342001547	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
546342001548	DNA binding residues [nucleotide binding]
546342001549	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
546342001550	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
546342001551	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
546342001552	putative homodimer interface [polypeptide binding]; other site
546342001553	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
546342001554	heterodimer interface [polypeptide binding]; other site
546342001555	homodimer interface [polypeptide binding]; other site
546342001556	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
546342001557	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
546342001558	23S rRNA interface [nucleotide binding]; other site
546342001559	L7/L12 interface [polypeptide binding]; other site
546342001560	putative thiostrepton binding site; other site
546342001561	L25 interface [polypeptide binding]; other site
546342001562	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
546342001563	mRNA/rRNA interface [nucleotide binding]; other site
546342001564	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
546342001565	23S rRNA interface [nucleotide binding]; other site
546342001566	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
546342001567	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
546342001568	peripheral dimer interface [polypeptide binding]; other site
546342001569	core dimer interface [polypeptide binding]; other site
546342001570	L10 interface [polypeptide binding]; other site
546342001571	L11 interface [polypeptide binding]; other site
546342001572	putative EF-Tu interaction site [polypeptide binding]; other site
546342001573	putative EF-G interaction site [polypeptide binding]; other site
546342001574	Methyltransferase domain; Region: Methyltransf_31; pfam13847
546342001575	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342001576	S-adenosylmethionine binding site [chemical binding]; other site
546342001577	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
546342001578	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
546342001579	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
546342001580	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
546342001581	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
546342001582	RPB10 interaction site [polypeptide binding]; other site
546342001583	RPB1 interaction site [polypeptide binding]; other site
546342001584	RPB11 interaction site [polypeptide binding]; other site
546342001585	RPB3 interaction site [polypeptide binding]; other site
546342001586	RPB12 interaction site [polypeptide binding]; other site
546342001587	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
546342001588	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
546342001589	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
546342001590	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
546342001591	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
546342001592	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
546342001593	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
546342001594	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
546342001595	G-loop; other site
546342001596	DNA binding site [nucleotide binding]
546342001597	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600
546342001598	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
546342001599	S17 interaction site [polypeptide binding]; other site
546342001600	S8 interaction site; other site
546342001601	16S rRNA interaction site [nucleotide binding]; other site
546342001602	streptomycin interaction site [chemical binding]; other site
546342001603	23S rRNA interaction site [nucleotide binding]; other site
546342001604	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
546342001605	30S ribosomal protein S7; Validated; Region: PRK05302
546342001606	elongation factor G; Reviewed; Region: PRK00007
546342001607	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
546342001608	G1 box; other site
546342001609	putative GEF interaction site [polypeptide binding]; other site
546342001610	GTP/Mg2+ binding site [chemical binding]; other site
546342001611	Switch I region; other site
546342001612	G2 box; other site
546342001613	G3 box; other site
546342001614	Switch II region; other site
546342001615	G4 box; other site
546342001616	G5 box; other site
546342001617	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
546342001618	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
546342001619	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
546342001620	elongation factor Tu; Reviewed; Region: PRK00049
546342001621	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
546342001622	G1 box; other site
546342001623	GEF interaction site [polypeptide binding]; other site
546342001624	GTP/Mg2+ binding site [chemical binding]; other site
546342001625	Switch I region; other site
546342001626	G2 box; other site
546342001627	G3 box; other site
546342001628	Switch II region; other site
546342001629	G4 box; other site
546342001630	G5 box; other site
546342001631	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
546342001632	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
546342001633	Antibiotic Binding Site [chemical binding]; other site
546342001634	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
546342001635	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
546342001636	metal binding site [ion binding]; metal-binding site
546342001637	dimer interface [polypeptide binding]; other site
546342001638	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
546342001639	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
546342001640	substrate-cofactor binding pocket; other site
546342001641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342001642	catalytic residue [active]
546342001643	chaperone protein HchA; Provisional; Region: PRK04155
546342001644	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
546342001645	dimer interface [polypeptide binding]; other site
546342001646	metal binding site [ion binding]; metal-binding site
546342001647	potential oxyanion hole; other site
546342001648	potential catalytic triad [active]
546342001649	conserved cys residue [active]
546342001650	ribulokinase; Provisional; Region: PRK04123
546342001651	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
546342001652	N- and C-terminal domain interface [polypeptide binding]; other site
546342001653	active site
546342001654	carbohydrate binding site [chemical binding]; other site
546342001655	MgATP binding site [chemical binding]; other site
546342001656	homodimer interface [polypeptide binding]; other site
546342001657	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546342001658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546342001659	NAD(P) binding site [chemical binding]; other site
546342001660	active site
546342001661	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
546342001662	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
546342001663	homodimer interface [polypeptide binding]; other site
546342001664	substrate-cofactor binding pocket; other site
546342001665	catalytic residue [active]
546342001666	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
546342001667	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342001668	motif II; other site
546342001669	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
546342001670	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
546342001671	Substrate-binding site [chemical binding]; other site
546342001672	Substrate specificity [chemical binding]; other site
546342001673	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
546342001674	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
546342001675	Substrate-binding site [chemical binding]; other site
546342001676	Substrate specificity [chemical binding]; other site
546342001677	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
546342001678	nucleoside/Zn binding site; other site
546342001679	dimer interface [polypeptide binding]; other site
546342001680	catalytic motif [active]
546342001681	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
546342001682	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342001683	active site
546342001684	motif I; other site
546342001685	motif II; other site
546342001686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342001687	Predicted flavoprotein [General function prediction only]; Region: COG0431
546342001688	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
546342001689	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
546342001690	Cna protein B-type domain; Region: Cna_B; pfam05738
546342001691	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546342001692	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546342001693	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546342001694	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546342001695	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
546342001696	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
546342001697	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546342001698	Cna protein B-type domain; Region: Cna_B; pfam05738
546342001699	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
546342001700	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
546342001701	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
546342001702	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546342001703	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
546342001704	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
546342001705	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546342001706	putative GTP cyclohydrolase; Provisional; Region: PRK13674
546342001707	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
546342001708	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
546342001709	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
546342001710	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
546342001711	active site
546342001712	trimer interface [polypeptide binding]; other site
546342001713	allosteric site; other site
546342001714	active site lid [active]
546342001715	hexamer (dimer of trimers) interface [polypeptide binding]; other site
546342001716	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
546342001717	active site
546342001718	dimer interface [polypeptide binding]; other site
546342001719	magnesium binding site [ion binding]; other site
546342001720	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
546342001721	tetramer interface [polypeptide binding]; other site
546342001722	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
546342001723	active site
546342001724	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
546342001725	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342001726	motif II; other site
546342001727	proline/glycine betaine transporter; Provisional; Region: PRK10642
546342001728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342001729	putative substrate translocation pore; other site
546342001730	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
546342001731	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
546342001732	acyl-activating enzyme (AAE) consensus motif; other site
546342001733	AMP binding site [chemical binding]; other site
546342001734	active site
546342001735	CoA binding site [chemical binding]; other site
546342001736	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
546342001737	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
546342001738	dimer interface [polypeptide binding]; other site
546342001739	active site
546342001740	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
546342001741	dimer interface [polypeptide binding]; other site
546342001742	substrate binding site [chemical binding]; other site
546342001743	ATP binding site [chemical binding]; other site
546342001744	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
546342001745	ligand binding site [chemical binding]; other site
546342001746	active site
546342001747	UGI interface [polypeptide binding]; other site
546342001748	catalytic site [active]
546342001749	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
546342001750	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
546342001751	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
546342001752	Uncharacterized conserved protein [Function unknown]; Region: COG2966
546342001753	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
546342001754	putative heme peroxidase; Provisional; Region: PRK12276
546342001755	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
546342001756	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
546342001757	mevalonate kinase; Region: mevalon_kin; TIGR00549
546342001758	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
546342001759	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
546342001760	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
546342001761	diphosphomevalonate decarboxylase; Region: PLN02407
546342001762	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
546342001763	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
546342001764	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
546342001765	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
546342001766	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
546342001767	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
546342001768	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342001769	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
546342001770	Predicted transcriptional regulator [Transcription]; Region: COG1959
546342001771	Transcriptional regulator; Region: Rrf2; pfam02082
546342001772	LXG domain of WXG superfamily; Region: LXG; pfam04740
546342001773	Protein of unknown function (DUF443); Region: DUF443; pfam04276
546342001774	Protein of unknown function (DUF443); Region: DUF443; pfam04276
546342001775	Protein of unknown function (DUF443); Region: DUF443; pfam04276
546342001776	Protein of unknown function (DUF443); Region: DUF443; pfam04276
546342001777	Protein of unknown function (DUF443); Region: DUF443; pfam04276
546342001778	Protein of unknown function (DUF443); Region: DUF443; pfam04276
546342001779	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342001780	MULE transposase domain; Region: MULE; pfam10551
546342001781	Protein of unknown function (DUF443); Region: DUF443; pfam04276
546342001782	Protein of unknown function (DUF443); Region: DUF443; pfam04276
546342001783	Protein of unknown function (DUF443); Region: DUF443; pfam04276
546342001784	Protein of unknown function (DUF443); Region: DUF443; pfam04276
546342001785	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546342001786	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546342001787	active site
546342001788	catalytic tetrad [active]
546342001789	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
546342001790	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
546342001791	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
546342001792	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342001793	Coenzyme A binding pocket [chemical binding]; other site
546342001794	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
546342001795	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546342001796	Zn2+ binding site [ion binding]; other site
546342001797	Mg2+ binding site [ion binding]; other site
546342001798	YwhD family; Region: YwhD; pfam08741
546342001799	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
546342001800	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
546342001801	NAD binding site [chemical binding]; other site
546342001802	substrate binding site [chemical binding]; other site
546342001803	catalytic Zn binding site [ion binding]; other site
546342001804	tetramer interface [polypeptide binding]; other site
546342001805	structural Zn binding site [ion binding]; other site
546342001806	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
546342001807	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
546342001808	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
546342001809	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
546342001810	active site
546342001811	HIGH motif; other site
546342001812	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546342001813	KMSK motif region; other site
546342001814	tRNA binding surface [nucleotide binding]; other site
546342001815	DALR anticodon binding domain; Region: DALR_1; smart00836
546342001816	anticodon binding site; other site
546342001817	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
546342001818	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546342001819	minor groove reading motif; other site
546342001820	helix-hairpin-helix signature motif; other site
546342001821	substrate binding pocket [chemical binding]; other site
546342001822	active site
546342001823	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
546342001824	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546342001825	putative binding site residues; other site
546342001826	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
546342001827	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342001828	ABC-ATPase subunit  interface; other site
546342001829	dimer interface [polypeptide binding]; other site
546342001830	putative PBP binding regions; other site
546342001831	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
546342001832	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342001833	motif II; other site
546342001834	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
546342001835	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546342001836	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
546342001837	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546342001838	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342001839	Transcriptional regulators [Transcription]; Region: MarR; COG1846
546342001840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
546342001841	Protein of unknown function, DUF606; Region: DUF606; pfam04657
546342001842	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
546342001843	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
546342001844	active site
546342001845	DNA binding site [nucleotide binding]
546342001846	Int/Topo IB signature motif; other site
546342001847	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
546342001848	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546342001849	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
546342001850	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574
546342001851	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660
546342001852	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
546342001853	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546342001854	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
546342001855	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657
546342001856	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
546342001857	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
546342001858	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
546342001859	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
546342001860	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
546342001861	metal binding site [ion binding]; metal-binding site
546342001862	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
546342001863	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342001864	ABC-ATPase subunit  interface; other site
546342001865	dimer interface [polypeptide binding]; other site
546342001866	putative PBP binding regions; other site
546342001867	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
546342001868	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
546342001869	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
546342001870	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
546342001871	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
546342001872	FeoA domain; Region: FeoA; pfam04023
546342001873	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
546342001874	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
546342001875	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
546342001876	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
546342001877	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
546342001878	Walker A/P-loop; other site
546342001879	ATP binding site [chemical binding]; other site
546342001880	Q-loop/lid; other site
546342001881	ABC transporter signature motif; other site
546342001882	Walker B; other site
546342001883	D-loop; other site
546342001884	H-loop/switch region; other site
546342001885	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
546342001886	ABC-2 type transporter; Region: ABC2_membrane; cl17235
546342001887	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
546342001888	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546342001889	active site
546342001890	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546342001891	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
546342001892	active site
546342001893	nucleotide binding site [chemical binding]; other site
546342001894	HIGH motif; other site
546342001895	KMSKS motif; other site
546342001896	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
546342001897	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
546342001898	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
546342001899	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546342001900	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546342001901	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342001902	Walker A/P-loop; other site
546342001903	ATP binding site [chemical binding]; other site
546342001904	Q-loop/lid; other site
546342001905	ABC transporter signature motif; other site
546342001906	Walker B; other site
546342001907	D-loop; other site
546342001908	H-loop/switch region; other site
546342001909	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
546342001910	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
546342001911	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
546342001912	Uncharacterized conserved protein [Function unknown]; Region: COG1284
546342001913	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
546342001914	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
546342001915	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
546342001916	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
546342001917	Walker A/P-loop; other site
546342001918	ATP binding site [chemical binding]; other site
546342001919	Q-loop/lid; other site
546342001920	ABC transporter signature motif; other site
546342001921	Walker B; other site
546342001922	D-loop; other site
546342001923	H-loop/switch region; other site
546342001924	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546342001925	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342001926	ABC-ATPase subunit  interface; other site
546342001927	dimer interface [polypeptide binding]; other site
546342001928	putative PBP binding regions; other site
546342001929	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342001930	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546342001931	ABC-ATPase subunit  interface; other site
546342001932	dimer interface [polypeptide binding]; other site
546342001933	putative PBP binding regions; other site
546342001934	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
546342001935	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
546342001936	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
546342001937	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
546342001938	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
546342001939	Uncharacterized membrane protein [Function unknown]; Region: COG3949
546342001940	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
546342001941	Na binding site [ion binding]; other site
546342001942	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
546342001943	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
546342001944	substrate binding pocket [chemical binding]; other site
546342001945	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546342001946	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
546342001947	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342001948	Coenzyme A binding pocket [chemical binding]; other site
546342001949	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546342001950	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546342001951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546342001952	NAD(P) binding site [chemical binding]; other site
546342001953	active site
546342001954	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546342001955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342001956	active site
546342001957	phosphorylation site [posttranslational modification]
546342001958	intermolecular recognition site; other site
546342001959	dimerization interface [polypeptide binding]; other site
546342001960	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546342001961	DNA binding site [nucleotide binding]
546342001962	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546342001963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342001964	ATP binding site [chemical binding]; other site
546342001965	Mg2+ binding site [ion binding]; other site
546342001966	G-X-G motif; other site
546342001967	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546342001968	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546342001969	Walker A/P-loop; other site
546342001970	ATP binding site [chemical binding]; other site
546342001971	Q-loop/lid; other site
546342001972	ABC transporter signature motif; other site
546342001973	Walker B; other site
546342001974	D-loop; other site
546342001975	H-loop/switch region; other site
546342001976	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
546342001977	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
546342001978	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546342001979	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
546342001980	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546342001981	Surface antigen [General function prediction only]; Region: COG3942
546342001982	CHAP domain; Region: CHAP; pfam05257
546342001983	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
546342001984	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
546342001985	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
546342001986	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342001987	hypothetical protein; Provisional; Region: PRK12378
546342001988	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
546342001989	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
546342001990	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546342001991	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546342001992	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
546342001993	dimerization interface [polypeptide binding]; other site
546342001994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342001995	sugar efflux transporter; Region: 2A0120; TIGR00899
546342001996	putative substrate translocation pore; other site
546342001997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
546342001998	Serine incorporator (Serinc); Region: Serinc; pfam03348
546342001999	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342002000	Coenzyme A binding pocket [chemical binding]; other site
546342002001	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
546342002002	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546342002003	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
546342002004	hypothetical protein; Validated; Region: PRK00124
546342002005	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
546342002006	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
546342002007	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
546342002008	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546342002009	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
546342002010	Walker A/P-loop; other site
546342002011	ATP binding site [chemical binding]; other site
546342002012	Q-loop/lid; other site
546342002013	ABC transporter signature motif; other site
546342002014	Walker B; other site
546342002015	D-loop; other site
546342002016	H-loop/switch region; other site
546342002017	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
546342002018	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546342002019	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
546342002020	Walker A/P-loop; other site
546342002021	ATP binding site [chemical binding]; other site
546342002022	Q-loop/lid; other site
546342002023	ABC transporter signature motif; other site
546342002024	Walker B; other site
546342002025	D-loop; other site
546342002026	H-loop/switch region; other site
546342002027	Transcriptional regulators [Transcription]; Region: MarR; COG1846
546342002028	MarR family; Region: MarR; pfam01047
546342002029	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
546342002030	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
546342002031	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
546342002032	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546342002033	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546342002034	active site
546342002035	catalytic tetrad [active]
546342002036	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
546342002037	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
546342002038	transmembrane helices; other site
546342002039	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
546342002040	DNA photolyase; Region: DNA_photolyase; pfam00875
546342002041	Predicted membrane protein [Function unknown]; Region: COG4330
546342002042	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
546342002043	trimer interface [polypeptide binding]; other site
546342002044	putative Zn binding site [ion binding]; other site
546342002045	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
546342002046	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342002047	putative substrate translocation pore; other site
546342002048	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
546342002049	putative deacylase active site [active]
546342002050	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
546342002051	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
546342002052	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
546342002053	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
546342002054	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
546342002055	putative substrate binding site [chemical binding]; other site
546342002056	putative ATP binding site [chemical binding]; other site
546342002057	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
546342002058	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
546342002059	active site
546342002060	phosphorylation site [posttranslational modification]
546342002061	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
546342002062	active site
546342002063	P-loop; other site
546342002064	phosphorylation site [posttranslational modification]
546342002065	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
546342002066	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
546342002067	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
546342002068	active site
546342002069	dimer interface [polypeptide binding]; other site
546342002070	Domain of unknown function DUF21; Region: DUF21; pfam01595
546342002071	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
546342002072	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
546342002073	Transporter associated domain; Region: CorC_HlyC; pfam03471
546342002074	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546342002075	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546342002076	active site
546342002077	catalytic tetrad [active]
546342002078	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
546342002079	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
546342002080	Ligand binding site; other site
546342002081	Putative Catalytic site; other site
546342002082	DXD motif; other site
546342002083	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546342002084	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546342002085	dimer interface [polypeptide binding]; other site
546342002086	phosphorylation site [posttranslational modification]
546342002087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342002088	ATP binding site [chemical binding]; other site
546342002089	Mg2+ binding site [ion binding]; other site
546342002090	G-X-G motif; other site
546342002091	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546342002092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342002093	active site
546342002094	phosphorylation site [posttranslational modification]
546342002095	intermolecular recognition site; other site
546342002096	dimerization interface [polypeptide binding]; other site
546342002097	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546342002098	DNA binding site [nucleotide binding]
546342002099	DoxX; Region: DoxX; pfam07681
546342002100	Electron transfer DM13; Region: DM13; pfam10517
546342002101	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
546342002102	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
546342002103	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
546342002104	active site
546342002105	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
546342002106	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
546342002107	Ligand Binding Site [chemical binding]; other site
546342002108	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
546342002109	Glutamine amidotransferase class-I; Region: GATase; pfam00117
546342002110	glutamine binding [chemical binding]; other site
546342002111	catalytic triad [active]
546342002112	aminodeoxychorismate synthase; Provisional; Region: PRK07508
546342002113	chorismate binding enzyme; Region: Chorismate_bind; cl10555
546342002114	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
546342002115	substrate-cofactor binding pocket; other site
546342002116	Aminotransferase class IV; Region: Aminotran_4; pfam01063
546342002117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342002118	catalytic residue [active]
546342002119	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
546342002120	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
546342002121	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
546342002122	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
546342002123	Sulfatase; Region: Sulfatase; pfam00884
546342002124	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
546342002125	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546342002126	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546342002127	ABC transporter; Region: ABC_tran_2; pfam12848
546342002128	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546342002129	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
546342002130	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546342002131	ATP binding site [chemical binding]; other site
546342002132	putative Mg++ binding site [ion binding]; other site
546342002133	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546342002134	nucleotide binding region [chemical binding]; other site
546342002135	ATP-binding site [chemical binding]; other site
546342002136	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
546342002137	HRDC domain; Region: HRDC; pfam00570
546342002138	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
546342002139	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
546342002140	Walker A/P-loop; other site
546342002141	ATP binding site [chemical binding]; other site
546342002142	Q-loop/lid; other site
546342002143	ABC transporter signature motif; other site
546342002144	Walker B; other site
546342002145	D-loop; other site
546342002146	H-loop/switch region; other site
546342002147	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
546342002148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342002149	dimer interface [polypeptide binding]; other site
546342002150	conserved gate region; other site
546342002151	ABC-ATPase subunit interface; other site
546342002152	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
546342002153	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
546342002154	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
546342002155	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546342002156	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342002157	homodimer interface [polypeptide binding]; other site
546342002158	catalytic residue [active]
546342002159	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
546342002160	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
546342002161	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
546342002162	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
546342002163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342002164	putative substrate translocation pore; other site
546342002165	POT family; Region: PTR2; cl17359
546342002166	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
546342002167	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
546342002168	Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780
546342002169	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
546342002170	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
546342002171	Class I ribonucleotide reductase; Region: RNR_I; cd01679
546342002172	active site
546342002173	dimer interface [polypeptide binding]; other site
546342002174	catalytic residues [active]
546342002175	effector binding site; other site
546342002176	R2 peptide binding site; other site
546342002177	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
546342002178	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
546342002179	dimer interface [polypeptide binding]; other site
546342002180	putative radical transfer pathway; other site
546342002181	diiron center [ion binding]; other site
546342002182	tyrosyl radical; other site
546342002183	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342002184	ABC-ATPase subunit  interface; other site
546342002185	dimer interface [polypeptide binding]; other site
546342002186	putative PBP binding regions; other site
546342002187	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342002188	ABC-ATPase subunit  interface; other site
546342002189	dimer interface [polypeptide binding]; other site
546342002190	putative PBP binding regions; other site
546342002191	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
546342002192	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
546342002193	Walker A/P-loop; other site
546342002194	ATP binding site [chemical binding]; other site
546342002195	Q-loop/lid; other site
546342002196	ABC transporter signature motif; other site
546342002197	Walker B; other site
546342002198	D-loop; other site
546342002199	H-loop/switch region; other site
546342002200	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
546342002201	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
546342002202	putative ligand binding residues [chemical binding]; other site
546342002203	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
546342002204	FAD binding domain; Region: FAD_binding_4; pfam01565
546342002205	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
546342002206	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
546342002207	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342002208	MULE transposase domain; Region: MULE; pfam10551
546342002209	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
546342002210	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
546342002211	peptidase T; Region: peptidase-T; TIGR01882
546342002212	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
546342002213	metal binding site [ion binding]; metal-binding site
546342002214	dimer interface [polypeptide binding]; other site
546342002215	Uncharacterized conserved protein [Function unknown]; Region: COG3610
546342002216	Uncharacterized conserved protein [Function unknown]; Region: COG2966
546342002217	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
546342002218	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
546342002219	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
546342002220	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
546342002221	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
546342002222	metal binding site [ion binding]; metal-binding site
546342002223	active site
546342002224	I-site; other site
546342002225	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
546342002226	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
546342002227	Mg++ binding site [ion binding]; other site
546342002228	putative catalytic motif [active]
546342002229	substrate binding site [chemical binding]; other site
546342002230	Uncharacterized conserved protein [Function unknown]; Region: COG1739
546342002231	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
546342002232	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
546342002233	EDD domain protein, DegV family; Region: DegV; TIGR00762
546342002234	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
546342002235	DEAD-like helicases superfamily; Region: DEXDc; smart00487
546342002236	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546342002237	ATP binding site [chemical binding]; other site
546342002238	putative Mg++ binding site [ion binding]; other site
546342002239	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546342002240	nucleotide binding region [chemical binding]; other site
546342002241	ATP-binding site [chemical binding]; other site
546342002242	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
546342002243	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546342002244	active site
546342002245	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
546342002246	30S subunit binding site; other site
546342002247	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
546342002248	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
546342002249	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
546342002250	nucleotide binding region [chemical binding]; other site
546342002251	ATP-binding site [chemical binding]; other site
546342002252	SEC-C motif; Region: SEC-C; pfam02810
546342002253	peptide chain release factor 2; Provisional; Region: PRK06746
546342002254	This domain is found in peptide chain release factors; Region: PCRF; smart00937
546342002255	RF-1 domain; Region: RF-1; pfam00472
546342002256	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
546342002257	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546342002258	Surface antigen [General function prediction only]; Region: COG3942
546342002259	CHAP domain; Region: CHAP; pfam05257
546342002260	HD domain; Region: HD_3; cl17350
546342002261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
546342002262	excinuclease ABC subunit B; Provisional; Region: PRK05298
546342002263	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546342002264	ATP binding site [chemical binding]; other site
546342002265	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546342002266	nucleotide binding region [chemical binding]; other site
546342002267	ATP-binding site [chemical binding]; other site
546342002268	Ultra-violet resistance protein B; Region: UvrB; pfam12344
546342002269	UvrB/uvrC motif; Region: UVR; pfam02151
546342002270	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
546342002271	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
546342002272	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
546342002273	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
546342002274	HPr kinase/phosphorylase; Provisional; Region: PRK05428
546342002275	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
546342002276	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
546342002277	Hpr binding site; other site
546342002278	active site
546342002279	homohexamer subunit interaction site [polypeptide binding]; other site
546342002280	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
546342002281	putative acyl transferase; Provisional; Region: PRK10191
546342002282	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
546342002283	trimer interface [polypeptide binding]; other site
546342002284	active site
546342002285	substrate binding site [chemical binding]; other site
546342002286	CoA binding site [chemical binding]; other site
546342002287	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
546342002288	binding surface
546342002289	TPR motif; other site
546342002290	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546342002291	TPR motif; other site
546342002292	binding surface
546342002293	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
546342002294	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546342002295	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342002296	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
546342002297	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
546342002298	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
546342002299	phosphate binding site [ion binding]; other site
546342002300	dimer interface [polypeptide binding]; other site
546342002301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
546342002302	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
546342002303	Clp protease; Region: CLP_protease; pfam00574
546342002304	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
546342002305	oligomer interface [polypeptide binding]; other site
546342002306	active site residues [active]
546342002307	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
546342002308	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546342002309	NAD(P) binding site [chemical binding]; other site
546342002310	active site
546342002311	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
546342002312	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
546342002313	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
546342002314	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
546342002315	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
546342002316	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
546342002317	Phosphoglycerate kinase; Region: PGK; pfam00162
546342002318	substrate binding site [chemical binding]; other site
546342002319	hinge regions; other site
546342002320	ADP binding site [chemical binding]; other site
546342002321	catalytic site [active]
546342002322	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
546342002323	triosephosphate isomerase; Provisional; Region: PRK14565
546342002324	substrate binding site [chemical binding]; other site
546342002325	dimer interface [polypeptide binding]; other site
546342002326	catalytic triad [active]
546342002327	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
546342002328	phosphoglyceromutase; Provisional; Region: PRK05434
546342002329	enolase; Provisional; Region: eno; PRK00077
546342002330	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
546342002331	dimer interface [polypeptide binding]; other site
546342002332	metal binding site [ion binding]; metal-binding site
546342002333	substrate binding pocket [chemical binding]; other site
546342002334	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
546342002335	Esterase/lipase [General function prediction only]; Region: COG1647
546342002336	Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735
546342002337	ribonuclease R; Region: RNase_R; TIGR02063
546342002338	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
546342002339	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
546342002340	RNB domain; Region: RNB; pfam00773
546342002341	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
546342002342	RNA binding site [nucleotide binding]; other site
546342002343	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
546342002344	SmpB-tmRNA interface; other site
546342002345	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342002346	Coenzyme A binding pocket [chemical binding]; other site
546342002347	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
546342002348	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
546342002349	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
546342002350	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
546342002351	Staphylococcal nuclease homologues; Region: SNc; smart00318
546342002352	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
546342002353	Catalytic site; other site
546342002354	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
546342002355	DNA-binding site [nucleotide binding]; DNA binding site
546342002356	RNA-binding motif; other site
546342002357	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
546342002358	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
546342002359	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546342002360	catalytic core [active]
546342002361	Lysine efflux permease [General function prediction only]; Region: COG1279
546342002362	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546342002363	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
546342002364	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546342002365	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
546342002366	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
546342002367	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
546342002368	active site
546342002369	catalytic residue [active]
546342002370	dimer interface [polypeptide binding]; other site
546342002371	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
546342002372	putative FMN binding site [chemical binding]; other site
546342002373	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
546342002374	catalytic residues [active]
546342002375	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
546342002376	ArsC family; Region: ArsC; pfam03960
546342002377	putative ArsC-like catalytic residues; other site
546342002378	putative TRX-like catalytic residues [active]
546342002379	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
546342002380	lipoyl attachment site [posttranslational modification]; other site
546342002381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
546342002382	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
546342002383	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
546342002384	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
546342002385	Int/Topo IB signature motif; other site
546342002386	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
546342002387	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
546342002388	Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195
546342002389	Int/Topo IB signature motif; other site
546342002390	aminoglycoside resistance protein; Provisional; Region: PRK13746
546342002391	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
546342002392	active site
546342002393	NTP binding site [chemical binding]; other site
546342002394	metal binding triad [ion binding]; metal-binding site
546342002395	antibiotic binding site [chemical binding]; other site
546342002396	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
546342002397	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
546342002398	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342002399	S-adenosylmethionine binding site [chemical binding]; other site
546342002400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342002401	S-adenosylmethionine binding site [chemical binding]; other site
546342002402	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
546342002403	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
546342002404	putative active site [active]
546342002405	putative metal binding site [ion binding]; other site
546342002406	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
546342002407	catalytic residues [active]
546342002408	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
546342002409	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
546342002410	Walker A/P-loop; other site
546342002411	ATP binding site [chemical binding]; other site
546342002412	Q-loop/lid; other site
546342002413	ABC transporter signature motif; other site
546342002414	Walker B; other site
546342002415	D-loop; other site
546342002416	H-loop/switch region; other site
546342002417	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
546342002418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342002419	dimer interface [polypeptide binding]; other site
546342002420	conserved gate region; other site
546342002421	ABC-ATPase subunit interface; other site
546342002422	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
546342002423	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
546342002424	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
546342002425	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
546342002426	Int/Topo IB signature motif; other site
546342002427	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
546342002428	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342002429	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
546342002430	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342002431	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546342002432	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342002433	non-specific DNA binding site [nucleotide binding]; other site
546342002434	salt bridge; other site
546342002435	sequence-specific DNA binding site [nucleotide binding]; other site
546342002436	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
546342002437	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
546342002438	Protein of unknown function (DUF1474); Region: DUF1474; pfam07342
546342002439	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
546342002440	Virulence-associated protein E; Region: VirE; pfam05272
546342002441	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
546342002442	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
546342002443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
546342002444	Predicted membrane protein [Function unknown]; Region: COG2035
546342002445	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
546342002446	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
546342002447	Walker A/P-loop; other site
546342002448	ATP binding site [chemical binding]; other site
546342002449	Q-loop/lid; other site
546342002450	ABC transporter signature motif; other site
546342002451	Walker B; other site
546342002452	D-loop; other site
546342002453	H-loop/switch region; other site
546342002454	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
546342002455	FeS assembly protein SufD; Region: sufD; TIGR01981
546342002456	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
546342002457	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
546342002458	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546342002459	catalytic residue [active]
546342002460	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
546342002461	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
546342002462	trimerization site [polypeptide binding]; other site
546342002463	active site
546342002464	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
546342002465	FeS assembly protein SufB; Region: sufB; TIGR01980
546342002466	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
546342002467	Domain of unknown function DUF21; Region: DUF21; pfam01595
546342002468	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
546342002469	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
546342002470	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
546342002471	FMN binding site [chemical binding]; other site
546342002472	substrate binding site [chemical binding]; other site
546342002473	putative catalytic residue [active]
546342002474	Uncharacterized conserved protein [Function unknown]; Region: COG1801
546342002475	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
546342002476	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
546342002477	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
546342002478	active site
546342002479	metal binding site [ion binding]; metal-binding site
546342002480	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
546342002481	lipoyl synthase; Provisional; Region: PRK05481
546342002482	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546342002483	FeS/SAM binding site; other site
546342002484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
546342002485	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
546342002486	Uncharacterized conserved protein [Function unknown]; Region: COG2445
546342002487	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
546342002488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342002489	active site
546342002490	motif I; other site
546342002491	motif II; other site
546342002492	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342002493	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
546342002494	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
546342002495	dimerization interface [polypeptide binding]; other site
546342002496	ligand binding site [chemical binding]; other site
546342002497	NADP binding site [chemical binding]; other site
546342002498	catalytic site [active]
546342002499	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
546342002500	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
546342002501	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
546342002502	acyl-activating enzyme (AAE) consensus motif; other site
546342002503	AMP binding site [chemical binding]; other site
546342002504	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
546342002505	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
546342002506	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
546342002507	DltD N-terminal region; Region: DltD_N; pfam04915
546342002508	DltD central region; Region: DltD_M; pfam04918
546342002509	DltD C-terminal region; Region: DltD_C; pfam04914
546342002510	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
546342002511	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
546342002512	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
546342002513	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342002514	hypothetical protein; Provisional; Region: PRK13669
546342002515	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
546342002516	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
546342002517	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342002518	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
546342002519	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
546342002520	interface (dimer of trimers) [polypeptide binding]; other site
546342002521	Substrate-binding/catalytic site; other site
546342002522	Zn-binding sites [ion binding]; other site
546342002523	Predicted permease [General function prediction only]; Region: COG2056
546342002524	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
546342002525	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
546342002526	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
546342002527	CoenzymeA binding site [chemical binding]; other site
546342002528	subunit interaction site [polypeptide binding]; other site
546342002529	PHB binding site; other site
546342002530	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546342002531	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
546342002532	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587
546342002533	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
546342002534	Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
546342002535	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
546342002536	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546342002537	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
546342002538	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
546342002539	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
546342002540	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
546342002541	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
546342002542	Kinase associated protein B; Region: KapB; pfam08810
546342002543	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
546342002544	active site
546342002545	general stress protein 13; Validated; Region: PRK08059
546342002546	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
546342002547	RNA binding site [nucleotide binding]; other site
546342002548	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
546342002549	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
546342002550	putative active site [active]
546342002551	putative FMN binding site [chemical binding]; other site
546342002552	putative substrate binding site [chemical binding]; other site
546342002553	putative catalytic residue [active]
546342002554	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
546342002555	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546342002556	inhibitor-cofactor binding pocket; inhibition site
546342002557	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342002558	catalytic residue [active]
546342002559	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
546342002560	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
546342002561	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
546342002562	NAD(P) binding site [chemical binding]; other site
546342002563	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
546342002564	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
546342002565	active site
546342002566	catalytic site [active]
546342002567	metal binding site [ion binding]; metal-binding site
546342002568	argininosuccinate lyase; Provisional; Region: PRK00855
546342002569	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
546342002570	active sites [active]
546342002571	tetramer interface [polypeptide binding]; other site
546342002572	argininosuccinate synthase; Provisional; Region: PRK13820
546342002573	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
546342002574	ANP binding site [chemical binding]; other site
546342002575	Substrate Binding Site II [chemical binding]; other site
546342002576	Substrate Binding Site I [chemical binding]; other site
546342002577	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
546342002578	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
546342002579	active site
546342002580	dimer interface [polypeptide binding]; other site
546342002581	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
546342002582	dimer interface [polypeptide binding]; other site
546342002583	active site
546342002584	Uncharacterized conserved protein [Function unknown]; Region: COG0398
546342002585	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
546342002586	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
546342002587	Catalytic site [active]
546342002588	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
546342002589	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
546342002590	Catalytic site [active]
546342002591	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
546342002592	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
546342002593	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
546342002594	Part of AAA domain; Region: AAA_19; pfam13245
546342002595	Family description; Region: UvrD_C_2; pfam13538
546342002596	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
546342002597	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
546342002598	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
546342002599	hypothetical protein; Provisional; Region: PRK13673
546342002600	coenzyme A disulfide reductase; Provisional; Region: PRK13512
546342002601	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546342002602	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342002603	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
546342002604	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
546342002605	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342002606	active site
546342002607	motif I; other site
546342002608	motif II; other site
546342002609	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342002610	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
546342002611	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
546342002612	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
546342002613	catalytic triad [active]
546342002614	catalytic triad [active]
546342002615	oxyanion hole [active]
546342002616	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
546342002617	Clp amino terminal domain; Region: Clp_N; pfam02861
546342002618	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342002619	Walker A motif; other site
546342002620	ATP binding site [chemical binding]; other site
546342002621	Walker B motif; other site
546342002622	arginine finger; other site
546342002623	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
546342002624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342002625	Walker A motif; other site
546342002626	ATP binding site [chemical binding]; other site
546342002627	Walker B motif; other site
546342002628	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
546342002629	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546342002630	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546342002631	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
546342002632	dimerization interface [polypeptide binding]; other site
546342002633	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
546342002634	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
546342002635	active site
546342002636	catalytic residues [active]
546342002637	metal binding site [ion binding]; metal-binding site
546342002638	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
546342002639	substrate binding site [chemical binding]; other site
546342002640	MAP domain; Region: MAP; pfam03642
546342002641	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
546342002642	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
546342002643	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
546342002644	dimer interface [polypeptide binding]; other site
546342002645	active site
546342002646	CoA binding pocket [chemical binding]; other site
546342002647	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
546342002648	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
546342002649	dimer interface [polypeptide binding]; other site
546342002650	active site
546342002651	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
546342002652	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546342002653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342002654	dimer interface [polypeptide binding]; other site
546342002655	conserved gate region; other site
546342002656	putative PBP binding loops; other site
546342002657	ABC-ATPase subunit interface; other site
546342002658	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546342002659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342002660	dimer interface [polypeptide binding]; other site
546342002661	conserved gate region; other site
546342002662	putative PBP binding loops; other site
546342002663	ABC-ATPase subunit interface; other site
546342002664	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
546342002665	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546342002666	Walker A/P-loop; other site
546342002667	ATP binding site [chemical binding]; other site
546342002668	Q-loop/lid; other site
546342002669	ABC transporter signature motif; other site
546342002670	Walker B; other site
546342002671	D-loop; other site
546342002672	H-loop/switch region; other site
546342002673	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
546342002674	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
546342002675	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546342002676	Walker A/P-loop; other site
546342002677	ATP binding site [chemical binding]; other site
546342002678	Q-loop/lid; other site
546342002679	ABC transporter signature motif; other site
546342002680	Walker B; other site
546342002681	D-loop; other site
546342002682	H-loop/switch region; other site
546342002683	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
546342002684	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
546342002685	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
546342002686	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
546342002687	peptide binding site [polypeptide binding]; other site
546342002688	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
546342002689	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
546342002690	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
546342002691	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546342002692	Walker A/P-loop; other site
546342002693	ATP binding site [chemical binding]; other site
546342002694	Q-loop/lid; other site
546342002695	ABC transporter signature motif; other site
546342002696	Walker B; other site
546342002697	D-loop; other site
546342002698	H-loop/switch region; other site
546342002699	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
546342002700	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
546342002701	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546342002702	Walker A/P-loop; other site
546342002703	ATP binding site [chemical binding]; other site
546342002704	Q-loop/lid; other site
546342002705	ABC transporter signature motif; other site
546342002706	Walker B; other site
546342002707	D-loop; other site
546342002708	H-loop/switch region; other site
546342002709	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
546342002710	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546342002711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342002712	dimer interface [polypeptide binding]; other site
546342002713	conserved gate region; other site
546342002714	putative PBP binding loops; other site
546342002715	ABC-ATPase subunit interface; other site
546342002716	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
546342002717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342002718	dimer interface [polypeptide binding]; other site
546342002719	conserved gate region; other site
546342002720	putative PBP binding loops; other site
546342002721	ABC-ATPase subunit interface; other site
546342002722	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
546342002723	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
546342002724	active site
546342002725	HIGH motif; other site
546342002726	dimer interface [polypeptide binding]; other site
546342002727	KMSKS motif; other site
546342002728	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
546342002729	ArsC family; Region: ArsC; pfam03960
546342002730	putative catalytic residues [active]
546342002731	thiol/disulfide switch; other site
546342002732	adaptor protein; Provisional; Region: PRK02315
546342002733	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
546342002734	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
546342002735	active site
546342002736	Zn binding site [ion binding]; other site
546342002737	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
546342002738	Thioredoxin; Region: Thioredoxin_5; pfam13743
546342002739	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
546342002740	apolar tunnel; other site
546342002741	heme binding site [chemical binding]; other site
546342002742	dimerization interface [polypeptide binding]; other site
546342002743	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
546342002744	putative active site [active]
546342002745	putative metal binding residues [ion binding]; other site
546342002746	signature motif; other site
546342002747	putative triphosphate binding site [ion binding]; other site
546342002748	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
546342002749	synthetase active site [active]
546342002750	NTP binding site [chemical binding]; other site
546342002751	metal binding site [ion binding]; metal-binding site
546342002752	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
546342002753	ATP-NAD kinase; Region: NAD_kinase; pfam01513
546342002754	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
546342002755	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
546342002756	active site
546342002757	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
546342002758	MgtE intracellular N domain; Region: MgtE_N; smart00924
546342002759	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
546342002760	Divalent cation transporter; Region: MgtE; pfam01769
546342002761	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
546342002762	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
546342002763	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
546342002764	TrkA-N domain; Region: TrkA_N; pfam02254
546342002765	TrkA-C domain; Region: TrkA_C; pfam02080
546342002766	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342002767	MULE transposase domain; Region: MULE; pfam10551
546342002768	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
546342002769	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
546342002770	NAD binding site [chemical binding]; other site
546342002771	homotetramer interface [polypeptide binding]; other site
546342002772	homodimer interface [polypeptide binding]; other site
546342002773	substrate binding site [chemical binding]; other site
546342002774	active site
546342002775	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
546342002776	Domain of unknown function DUF20; Region: UPF0118; pfam01594
546342002777	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
546342002778	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
546342002779	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
546342002780	Putative esterase; Region: Esterase; pfam00756
546342002781	hypothetical protein; Provisional; Region: PRK13679
546342002782	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
546342002783	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342002784	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342002785	putative substrate translocation pore; other site
546342002786	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
546342002787	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
546342002788	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546342002789	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
546342002790	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
546342002791	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546342002792	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546342002793	YueH-like protein; Region: YueH; pfam14166
546342002794	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
546342002795	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
546342002796	G1 box; other site
546342002797	putative GEF interaction site [polypeptide binding]; other site
546342002798	GTP/Mg2+ binding site [chemical binding]; other site
546342002799	Switch I region; other site
546342002800	G2 box; other site
546342002801	G3 box; other site
546342002802	Switch II region; other site
546342002803	G4 box; other site
546342002804	G5 box; other site
546342002805	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
546342002806	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
546342002807	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
546342002808	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
546342002809	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546342002810	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
546342002811	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
546342002812	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
546342002813	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
546342002814	active site
546342002815	metal binding site [ion binding]; metal-binding site
546342002816	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
546342002817	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
546342002818	IDEAL domain; Region: IDEAL; pfam08858
546342002819	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
546342002820	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
546342002821	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
546342002822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
546342002823	CAAX protease self-immunity; Region: Abi; pfam02517
546342002824	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
546342002825	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
546342002826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
546342002827	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546342002828	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
546342002829	Walker A/P-loop; other site
546342002830	ATP binding site [chemical binding]; other site
546342002831	Q-loop/lid; other site
546342002832	ABC transporter signature motif; other site
546342002833	Walker B; other site
546342002834	D-loop; other site
546342002835	H-loop/switch region; other site
546342002836	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
546342002837	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
546342002838	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
546342002839	Predicted membrane protein [Function unknown]; Region: COG2259
546342002840	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
546342002841	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
546342002842	siderophore binding site; other site
546342002843	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
546342002844	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342002845	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
546342002846	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546342002847	Coenzyme A binding pocket [chemical binding]; other site
546342002848	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
546342002849	UbiA prenyltransferase family; Region: UbiA; pfam01040
546342002850	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
546342002851	isochorismate synthases; Region: isochor_syn; TIGR00543
546342002852	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
546342002853	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
546342002854	dimer interface [polypeptide binding]; other site
546342002855	tetramer interface [polypeptide binding]; other site
546342002856	PYR/PP interface [polypeptide binding]; other site
546342002857	TPP binding site [chemical binding]; other site
546342002858	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
546342002859	TPP-binding site; other site
546342002860	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
546342002861	PGAP1-like protein; Region: PGAP1; pfam07819
546342002862	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
546342002863	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
546342002864	substrate binding site [chemical binding]; other site
546342002865	oxyanion hole (OAH) forming residues; other site
546342002866	trimer interface [polypeptide binding]; other site
546342002867	Staphostatin B; Region: Staphostatin_B; pfam09023
546342002868	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
546342002869	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
546342002870	aminotransferase A; Validated; Region: PRK07683
546342002871	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546342002872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342002873	homodimer interface [polypeptide binding]; other site
546342002874	catalytic residue [active]
546342002875	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
546342002876	Acyltransferase family; Region: Acyl_transf_3; pfam01757
546342002877	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546342002878	MarR family; Region: MarR; pfam01047
546342002879	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
546342002880	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
546342002881	amidase catalytic site [active]
546342002882	Zn binding residues [ion binding]; other site
546342002883	substrate binding site [chemical binding]; other site
546342002884	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
546342002885	Lysozyme subfamily 2; Region: LYZ2; smart00047
546342002886	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342002887	Coenzyme A binding pocket [chemical binding]; other site
546342002888	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342002889	MULE transposase domain; Region: MULE; pfam10551
546342002890	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
546342002891	Transcriptional regulator [Transcription]; Region: LytR; COG1316
546342002892	Beta-lactamase; Region: Beta-lactamase; pfam00144
546342002893	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
546342002894	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
546342002895	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
546342002896	Subunit I/III interface [polypeptide binding]; other site
546342002897	Subunit III/IV interface [polypeptide binding]; other site
546342002898	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
546342002899	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
546342002900	D-pathway; other site
546342002901	Putative ubiquinol binding site [chemical binding]; other site
546342002902	Low-spin heme (heme b) binding site [chemical binding]; other site
546342002903	Putative water exit pathway; other site
546342002904	Binuclear center (heme o3/CuB) [ion binding]; other site
546342002905	K-pathway; other site
546342002906	Putative proton exit pathway; other site
546342002907	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
546342002908	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
546342002909	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
546342002910	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
546342002911	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
546342002912	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
546342002913	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
546342002914	homodimer interface [polypeptide binding]; other site
546342002915	NADP binding site [chemical binding]; other site
546342002916	substrate binding site [chemical binding]; other site
546342002917	AIR carboxylase; Region: AIRC; cl00310
546342002918	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
546342002919	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
546342002920	NAD binding site [chemical binding]; other site
546342002921	ATP-grasp domain; Region: ATP-grasp; pfam02222
546342002922	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
546342002923	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
546342002924	ATP binding site [chemical binding]; other site
546342002925	active site
546342002926	substrate binding site [chemical binding]; other site
546342002927	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
546342002928	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
546342002929	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
546342002930	putative active site [active]
546342002931	catalytic triad [active]
546342002932	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
546342002933	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
546342002934	dimerization interface [polypeptide binding]; other site
546342002935	ATP binding site [chemical binding]; other site
546342002936	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
546342002937	dimerization interface [polypeptide binding]; other site
546342002938	ATP binding site [chemical binding]; other site
546342002939	amidophosphoribosyltransferase; Provisional; Region: PRK07272
546342002940	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
546342002941	active site
546342002942	tetramer interface [polypeptide binding]; other site
546342002943	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546342002944	active site
546342002945	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
546342002946	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
546342002947	dimerization interface [polypeptide binding]; other site
546342002948	putative ATP binding site [chemical binding]; other site
546342002949	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
546342002950	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
546342002951	active site
546342002952	substrate binding site [chemical binding]; other site
546342002953	cosubstrate binding site; other site
546342002954	catalytic site [active]
546342002955	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
546342002956	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
546342002957	purine monophosphate binding site [chemical binding]; other site
546342002958	dimer interface [polypeptide binding]; other site
546342002959	putative catalytic residues [active]
546342002960	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
546342002961	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
546342002962	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
546342002963	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
546342002964	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
546342002965	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
546342002966	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
546342002967	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
546342002968	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
546342002969	Walker A/P-loop; other site
546342002970	ATP binding site [chemical binding]; other site
546342002971	Q-loop/lid; other site
546342002972	ABC transporter signature motif; other site
546342002973	Walker B; other site
546342002974	D-loop; other site
546342002975	H-loop/switch region; other site
546342002976	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
546342002977	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
546342002978	Walker A/P-loop; other site
546342002979	ATP binding site [chemical binding]; other site
546342002980	Q-loop/lid; other site
546342002981	ABC transporter signature motif; other site
546342002982	Walker B; other site
546342002983	D-loop; other site
546342002984	H-loop/switch region; other site
546342002985	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
546342002986	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
546342002987	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
546342002988	putative RNA binding site [nucleotide binding]; other site
546342002989	Methyltransferase domain; Region: Methyltransf_26; pfam13659
546342002990	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
546342002991	dimerization domain swap beta strand [polypeptide binding]; other site
546342002992	regulatory protein interface [polypeptide binding]; other site
546342002993	active site
546342002994	regulatory phosphorylation site [posttranslational modification]; other site
546342002995	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
546342002996	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
546342002997	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
546342002998	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
546342002999	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
546342003000	catalytic residues [active]
546342003001	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
546342003002	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
546342003003	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
546342003004	TrkA-N domain; Region: TrkA_N; pfam02254
546342003005	TrkA-C domain; Region: TrkA_C; pfam02080
546342003006	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
546342003007	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
546342003008	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
546342003009	hypothetical protein; Provisional; Region: PRK13667
546342003010	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
546342003011	active site
546342003012	catalytic residues [active]
546342003013	metal binding site [ion binding]; metal-binding site
546342003014	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
546342003015	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
546342003016	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
546342003017	TPP-binding site [chemical binding]; other site
546342003018	tetramer interface [polypeptide binding]; other site
546342003019	heterodimer interface [polypeptide binding]; other site
546342003020	phosphorylation loop region [posttranslational modification]
546342003021	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
546342003022	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
546342003023	alpha subunit interface [polypeptide binding]; other site
546342003024	TPP binding site [chemical binding]; other site
546342003025	heterodimer interface [polypeptide binding]; other site
546342003026	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
546342003027	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
546342003028	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
546342003029	E3 interaction surface; other site
546342003030	lipoyl attachment site [posttranslational modification]; other site
546342003031	e3 binding domain; Region: E3_binding; pfam02817
546342003032	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
546342003033	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
546342003034	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546342003035	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342003036	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
546342003037	hypothetical protein; Provisional; Region: PRK04387
546342003038	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546342003039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342003040	non-specific DNA binding site [nucleotide binding]; other site
546342003041	salt bridge; other site
546342003042	sequence-specific DNA binding site [nucleotide binding]; other site
546342003043	Cupin domain; Region: Cupin_2; pfam07883
546342003044	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
546342003045	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342003046	Walker A/P-loop; other site
546342003047	ATP binding site [chemical binding]; other site
546342003048	Q-loop/lid; other site
546342003049	ABC transporter signature motif; other site
546342003050	Walker B; other site
546342003051	D-loop; other site
546342003052	H-loop/switch region; other site
546342003053	TOBE domain; Region: TOBE_2; pfam08402
546342003054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342003055	putative PBP binding loops; other site
546342003056	dimer interface [polypeptide binding]; other site
546342003057	ABC-ATPase subunit interface; other site
546342003058	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
546342003059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342003060	dimer interface [polypeptide binding]; other site
546342003061	conserved gate region; other site
546342003062	putative PBP binding loops; other site
546342003063	ABC-ATPase subunit interface; other site
546342003064	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
546342003065	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
546342003066	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
546342003067	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
546342003068	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
546342003069	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
546342003070	manganese transport protein MntH; Reviewed; Region: PRK00701
546342003071	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
546342003072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
546342003073	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
546342003074	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
546342003075	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
546342003076	active site
546342003077	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
546342003078	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
546342003079	G1 box; other site
546342003080	putative GEF interaction site [polypeptide binding]; other site
546342003081	GTP/Mg2+ binding site [chemical binding]; other site
546342003082	Switch I region; other site
546342003083	G2 box; other site
546342003084	G3 box; other site
546342003085	Switch II region; other site
546342003086	G4 box; other site
546342003087	G5 box; other site
546342003088	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
546342003089	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
546342003090	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
546342003091	hypothetical protein; Provisional; Region: PRK13666
546342003092	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
546342003093	pyruvate carboxylase; Reviewed; Region: PRK12999
546342003094	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546342003095	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
546342003096	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
546342003097	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
546342003098	active site
546342003099	catalytic residues [active]
546342003100	metal binding site [ion binding]; metal-binding site
546342003101	homodimer binding site [polypeptide binding]; other site
546342003102	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
546342003103	carboxyltransferase (CT) interaction site; other site
546342003104	biotinylation site [posttranslational modification]; other site
546342003105	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
546342003106	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
546342003107	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
546342003108	UbiA prenyltransferase family; Region: UbiA; pfam01040
546342003109	Predicted membrane protein [Function unknown]; Region: COG2322
546342003110	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
546342003111	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
546342003112	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
546342003113	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
546342003114	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
546342003115	putative active site [active]
546342003116	catalytic site [active]
546342003117	putative metal binding site [ion binding]; other site
546342003118	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471
546342003119	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
546342003120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342003121	S-adenosylmethionine binding site [chemical binding]; other site
546342003122	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
546342003123	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
546342003124	active site
546342003125	(T/H)XGH motif; other site
546342003126	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
546342003127	hypothetical protein; Provisional; Region: PRK13670
546342003128	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
546342003129	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
546342003130	heme uptake protein IsdB; Region: IsdB; TIGR03657
546342003131	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
546342003132	NEAr Transporter domain; Region: NEAT; smart00725
546342003133	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
546342003134	heme-binding site [chemical binding]; other site
546342003135	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
546342003136	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
546342003137	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
546342003138	heme-binding site [chemical binding]; other site
546342003139	heme uptake protein IsdC; Region: IsdC; TIGR03656
546342003140	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
546342003141	heme-binding site [chemical binding]; other site
546342003142	sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
546342003143	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546342003144	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546342003145	intersubunit interface [polypeptide binding]; other site
546342003146	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546342003147	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342003148	ABC-ATPase subunit  interface; other site
546342003149	dimer interface [polypeptide binding]; other site
546342003150	putative PBP binding regions; other site
546342003151	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
546342003152	active site
546342003153	catalytic site [active]
546342003154	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312
546342003155	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
546342003156	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
546342003157	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
546342003158	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
546342003159	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
546342003160	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
546342003161	dimer interface [polypeptide binding]; other site
546342003162	motif 1; other site
546342003163	active site
546342003164	motif 2; other site
546342003165	motif 3; other site
546342003166	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
546342003167	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
546342003168	putative tRNA-binding site [nucleotide binding]; other site
546342003169	B3/4 domain; Region: B3_4; pfam03483
546342003170	tRNA synthetase B5 domain; Region: B5; smart00874
546342003171	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
546342003172	dimer interface [polypeptide binding]; other site
546342003173	motif 1; other site
546342003174	motif 3; other site
546342003175	motif 2; other site
546342003176	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
546342003177	ribonuclease HIII; Provisional; Region: PRK00996
546342003178	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
546342003179	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
546342003180	RNA/DNA hybrid binding site [nucleotide binding]; other site
546342003181	active site
546342003182	Cell division protein ZapA; Region: ZapA; cl01146
546342003183	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
546342003184	Colicin V production protein; Region: Colicin_V; pfam02674
546342003185	hypothetical protein; Provisional; Region: PRK08609
546342003186	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
546342003187	active site
546342003188	primer binding site [nucleotide binding]; other site
546342003189	NTP  binding site [chemical binding]; other site
546342003190	metal binding triad [ion binding]; metal-binding site
546342003191	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
546342003192	active site
546342003193	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
546342003194	MutS domain III; Region: MutS_III; pfam05192
546342003195	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
546342003196	Walker A/P-loop; other site
546342003197	ATP binding site [chemical binding]; other site
546342003198	Q-loop/lid; other site
546342003199	ABC transporter signature motif; other site
546342003200	Walker B; other site
546342003201	D-loop; other site
546342003202	H-loop/switch region; other site
546342003203	Smr domain; Region: Smr; pfam01713
546342003204	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
546342003205	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
546342003206	catalytic residues [active]
546342003207	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
546342003208	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
546342003209	GIY-YIG motif/motif A; other site
546342003210	active site
546342003211	catalytic site [active]
546342003212	putative DNA binding site [nucleotide binding]; other site
546342003213	metal binding site [ion binding]; metal-binding site
546342003214	UvrB/uvrC motif; Region: UVR; pfam02151
546342003215	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
546342003216	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
546342003217	putative Iron-sulfur protein interface [polypeptide binding]; other site
546342003218	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
546342003219	proximal heme binding site [chemical binding]; other site
546342003220	distal heme binding site [chemical binding]; other site
546342003221	putative dimer interface [polypeptide binding]; other site
546342003222	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
546342003223	L-aspartate oxidase; Provisional; Region: PRK06175
546342003224	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
546342003225	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
546342003226	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
546342003227	glutamate racemase; Provisional; Region: PRK00865
546342003228	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
546342003229	active site
546342003230	dimerization interface [polypeptide binding]; other site
546342003231	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
546342003232	active site
546342003233	metal binding site [ion binding]; metal-binding site
546342003234	homotetramer interface [polypeptide binding]; other site
546342003235	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
546342003236	formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033
546342003237	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
546342003238	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
546342003239	beta-channel forming cytolysin; Region: hlyII; TIGR01002
546342003240	superantigen-like protein; Reviewed; Region: PRK13350
546342003241	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342003242	superantigen-like protein; Reviewed; Region: PRK13349
546342003243	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342003244	superantigen-like protein; Reviewed; Region: PRK13043
546342003245	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342003246	ornithine carbamoyltransferase; Provisional; Region: PRK04284
546342003247	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
546342003248	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
546342003249	carbamate kinase; Reviewed; Region: PRK12686
546342003250	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
546342003251	putative substrate binding site [chemical binding]; other site
546342003252	nucleotide binding site [chemical binding]; other site
546342003253	nucleotide binding site [chemical binding]; other site
546342003254	homodimer interface [polypeptide binding]; other site
546342003255	Predicted membrane protein [Function unknown]; Region: COG1288
546342003256	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
546342003257	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
546342003258	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
546342003259	gating phenylalanine in ion channel; other site
546342003260	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
546342003261	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
546342003262	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
546342003263	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342003264	motif II; other site
546342003265	hypothetical protein; Provisional; Region: PRK13688
546342003266	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
546342003267	Coenzyme A binding pocket [chemical binding]; other site
546342003268	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
546342003269	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
546342003270	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
546342003271	MraZ protein; Region: MraZ; pfam02381
546342003272	MraZ protein; Region: MraZ; pfam02381
546342003273	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
546342003274	MraW methylase family; Region: Methyltransf_5; pfam01795
546342003275	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
546342003276	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
546342003277	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
546342003278	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546342003279	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
546342003280	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
546342003281	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
546342003282	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
546342003283	Mg++ binding site [ion binding]; other site
546342003284	putative catalytic motif [active]
546342003285	putative substrate binding site [chemical binding]; other site
546342003286	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
546342003287	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
546342003288	NAD binding site [chemical binding]; other site
546342003289	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546342003290	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546342003291	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
546342003292	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
546342003293	Cell division protein FtsQ; Region: FtsQ; pfam03799
546342003294	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
546342003295	Cell division protein FtsA; Region: FtsA; smart00842
546342003296	Cell division protein FtsA; Region: FtsA; pfam14450
546342003297	cell division protein FtsZ; Validated; Region: PRK09330
546342003298	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
546342003299	nucleotide binding site [chemical binding]; other site
546342003300	SulA interaction site; other site
546342003301	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
546342003302	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
546342003303	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
546342003304	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546342003305	catalytic residue [active]
546342003306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
546342003307	YGGT family; Region: YGGT; pfam02325
546342003308	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
546342003309	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546342003310	RNA binding surface [nucleotide binding]; other site
546342003311	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
546342003312	DivIVA domain; Region: DivI1A_domain; TIGR03544
546342003313	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
546342003314	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
546342003315	HIGH motif; other site
546342003316	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
546342003317	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
546342003318	active site
546342003319	KMSKS motif; other site
546342003320	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
546342003321	tRNA binding surface [nucleotide binding]; other site
546342003322	anticodon binding site; other site
546342003323	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
546342003324	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
546342003325	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
546342003326	active site
546342003327	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
546342003328	lipoprotein signal peptidase; Provisional; Region: PRK14787
546342003329	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
546342003330	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546342003331	RNA binding surface [nucleotide binding]; other site
546342003332	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
546342003333	active site
546342003334	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
546342003335	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
546342003336	uracil transporter; Provisional; Region: PRK10720
546342003337	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
546342003338	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
546342003339	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
546342003340	dihydroorotase; Validated; Region: pyrC; PRK09357
546342003341	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
546342003342	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
546342003343	active site
546342003344	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
546342003345	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
546342003346	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
546342003347	catalytic site [active]
546342003348	subunit interface [polypeptide binding]; other site
546342003349	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
546342003350	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546342003351	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
546342003352	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
546342003353	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546342003354	ATP-grasp domain; Region: ATP-grasp_4; cl17255
546342003355	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
546342003356	IMP binding site; other site
546342003357	dimer interface [polypeptide binding]; other site
546342003358	interdomain contacts; other site
546342003359	partial ornithine binding site; other site
546342003360	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
546342003361	active site
546342003362	dimer interface [polypeptide binding]; other site
546342003363	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546342003364	active site
546342003365	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
546342003366	dimer interface [polypeptide binding]; other site
546342003367	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
546342003368	Domain of unknown function (DUF814); Region: DUF814; pfam05670
546342003369	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
546342003370	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
546342003371	catalytic site [active]
546342003372	G-X2-G-X-G-K; other site
546342003373	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
546342003374	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
546342003375	Flavoprotein; Region: Flavoprotein; pfam02441
546342003376	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
546342003377	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
546342003378	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546342003379	ATP binding site [chemical binding]; other site
546342003380	putative Mg++ binding site [ion binding]; other site
546342003381	helicase superfamily c-terminal domain; Region: HELICc; smart00490
546342003382	nucleotide binding region [chemical binding]; other site
546342003383	ATP-binding site [chemical binding]; other site
546342003384	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
546342003385	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
546342003386	active site
546342003387	catalytic residues [active]
546342003388	metal binding site [ion binding]; metal-binding site
546342003389	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
546342003390	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
546342003391	putative active site [active]
546342003392	substrate binding site [chemical binding]; other site
546342003393	putative cosubstrate binding site; other site
546342003394	catalytic site [active]
546342003395	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
546342003396	substrate binding site [chemical binding]; other site
546342003397	16S rRNA methyltransferase B; Provisional; Region: PRK14902
546342003398	NusB family; Region: NusB; pfam01029
546342003399	putative RNA binding site [nucleotide binding]; other site
546342003400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342003401	S-adenosylmethionine binding site [chemical binding]; other site
546342003402	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
546342003403	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546342003404	FeS/SAM binding site; other site
546342003405	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
546342003406	Protein phosphatase 2C; Region: PP2C; pfam00481
546342003407	active site
546342003408	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
546342003409	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
546342003410	active site
546342003411	ATP binding site [chemical binding]; other site
546342003412	substrate binding site [chemical binding]; other site
546342003413	activation loop (A-loop); other site
546342003414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
546342003415	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
546342003416	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
546342003417	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
546342003418	Predicted GTPases [General function prediction only]; Region: COG1162
546342003419	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
546342003420	RNA binding site [nucleotide binding]; other site
546342003421	homodimer interface [polypeptide binding]; other site
546342003422	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
546342003423	GTPase/Zn-binding domain interface [polypeptide binding]; other site
546342003424	GTP/Mg2+ binding site [chemical binding]; other site
546342003425	G4 box; other site
546342003426	G5 box; other site
546342003427	G1 box; other site
546342003428	Switch I region; other site
546342003429	G2 box; other site
546342003430	G3 box; other site
546342003431	Switch II region; other site
546342003432	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
546342003433	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
546342003434	substrate binding site [chemical binding]; other site
546342003435	hexamer interface [polypeptide binding]; other site
546342003436	metal binding site [ion binding]; metal-binding site
546342003437	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
546342003438	Thiamine pyrophosphokinase; Region: TPK; cd07995
546342003439	active site
546342003440	dimerization interface [polypeptide binding]; other site
546342003441	thiamine binding site [chemical binding]; other site
546342003442	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
546342003443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
546342003444	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
546342003445	DAK2 domain; Region: Dak2; pfam02734
546342003446	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
546342003447	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
546342003448	generic binding surface II; other site
546342003449	ssDNA binding site; other site
546342003450	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546342003451	ATP binding site [chemical binding]; other site
546342003452	putative Mg++ binding site [ion binding]; other site
546342003453	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546342003454	nucleotide binding region [chemical binding]; other site
546342003455	ATP-binding site [chemical binding]; other site
546342003456	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
546342003457	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
546342003458	active site 2 [active]
546342003459	active site 1 [active]
546342003460	putative phosphate acyltransferase; Provisional; Region: PRK05331
546342003461	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
546342003462	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
546342003463	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
546342003464	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
546342003465	NAD(P) binding site [chemical binding]; other site
546342003466	homotetramer interface [polypeptide binding]; other site
546342003467	homodimer interface [polypeptide binding]; other site
546342003468	active site
546342003469	acyl carrier protein; Provisional; Region: acpP; PRK00982
546342003470	ribonuclease III; Reviewed; Region: rnc; PRK00102
546342003471	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
546342003472	dimerization interface [polypeptide binding]; other site
546342003473	active site
546342003474	metal binding site [ion binding]; metal-binding site
546342003475	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
546342003476	dsRNA binding site [nucleotide binding]; other site
546342003477	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
546342003478	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
546342003479	Walker A/P-loop; other site
546342003480	ATP binding site [chemical binding]; other site
546342003481	Q-loop/lid; other site
546342003482	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
546342003483	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
546342003484	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
546342003485	ABC transporter signature motif; other site
546342003486	Walker B; other site
546342003487	D-loop; other site
546342003488	H-loop/switch region; other site
546342003489	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
546342003490	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
546342003491	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
546342003492	P loop; other site
546342003493	GTP binding site [chemical binding]; other site
546342003494	putative DNA-binding protein; Validated; Region: PRK00118
546342003495	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
546342003496	signal recognition particle protein; Provisional; Region: PRK10867
546342003497	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
546342003498	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
546342003499	P loop; other site
546342003500	GTP binding site [chemical binding]; other site
546342003501	Signal peptide binding domain; Region: SRP_SPB; pfam02978
546342003502	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
546342003503	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
546342003504	RimM N-terminal domain; Region: RimM; pfam01782
546342003505	PRC-barrel domain; Region: PRC; pfam05239
546342003506	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
546342003507	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
546342003508	Predicted membrane protein [Function unknown]; Region: COG4485
546342003509	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
546342003510	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
546342003511	GTP/Mg2+ binding site [chemical binding]; other site
546342003512	G4 box; other site
546342003513	G5 box; other site
546342003514	G1 box; other site
546342003515	Switch I region; other site
546342003516	G2 box; other site
546342003517	G3 box; other site
546342003518	Switch II region; other site
546342003519	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
546342003520	RNA/DNA hybrid binding site [nucleotide binding]; other site
546342003521	active site
546342003522	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
546342003523	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
546342003524	CoA-ligase; Region: Ligase_CoA; pfam00549
546342003525	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
546342003526	CoA binding domain; Region: CoA_binding; pfam02629
546342003527	CoA-ligase; Region: Ligase_CoA; pfam00549
546342003528	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
546342003529	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546342003530	CHAP domain; Region: CHAP; pfam05257
546342003531	FemAB family; Region: FemAB; pfam02388
546342003532	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
546342003533	DNA protecting protein DprA; Region: dprA; TIGR00732
546342003534	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
546342003535	DNA topoisomerase I; Validated; Region: PRK05582
546342003536	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
546342003537	active site
546342003538	interdomain interaction site; other site
546342003539	putative metal-binding site [ion binding]; other site
546342003540	nucleotide binding site [chemical binding]; other site
546342003541	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
546342003542	domain I; other site
546342003543	DNA binding groove [nucleotide binding]
546342003544	phosphate binding site [ion binding]; other site
546342003545	domain II; other site
546342003546	domain III; other site
546342003547	nucleotide binding site [chemical binding]; other site
546342003548	catalytic site [active]
546342003549	domain IV; other site
546342003550	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
546342003551	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
546342003552	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
546342003553	Glucose inhibited division protein A; Region: GIDA; pfam01134
546342003554	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
546342003555	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
546342003556	active site
546342003557	DNA binding site [nucleotide binding]
546342003558	Int/Topo IB signature motif; other site
546342003559	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
546342003560	active site
546342003561	HslU subunit interaction site [polypeptide binding]; other site
546342003562	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
546342003563	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342003564	Walker A motif; other site
546342003565	ATP binding site [chemical binding]; other site
546342003566	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
546342003567	Walker B motif; other site
546342003568	arginine finger; other site
546342003569	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
546342003570	transcriptional repressor CodY; Validated; Region: PRK04158
546342003571	CodY GAF-like domain; Region: CodY; pfam06018
546342003572	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
546342003573	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
546342003574	rRNA interaction site [nucleotide binding]; other site
546342003575	S8 interaction site; other site
546342003576	putative laminin-1 binding site; other site
546342003577	elongation factor Ts; Provisional; Region: tsf; PRK09377
546342003578	UBA/TS-N domain; Region: UBA; pfam00627
546342003579	Elongation factor TS; Region: EF_TS; pfam00889
546342003580	Elongation factor TS; Region: EF_TS; pfam00889
546342003581	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
546342003582	putative nucleotide binding site [chemical binding]; other site
546342003583	uridine monophosphate binding site [chemical binding]; other site
546342003584	homohexameric interface [polypeptide binding]; other site
546342003585	ribosome recycling factor; Reviewed; Region: frr; PRK00083
546342003586	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
546342003587	hinge region; other site
546342003588	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
546342003589	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
546342003590	catalytic residue [active]
546342003591	putative FPP diphosphate  binding site; other site
546342003592	putative FPP binding hydrophobic cleft; other site
546342003593	dimer interface [polypeptide binding]; other site
546342003594	putative IPP diphosphate binding site; other site
546342003595	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
546342003596	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
546342003597	RIP metalloprotease RseP; Region: TIGR00054
546342003598	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
546342003599	active site
546342003600	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
546342003601	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
546342003602	protein binding site [polypeptide binding]; other site
546342003603	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
546342003604	putative substrate binding region [chemical binding]; other site
546342003605	prolyl-tRNA synthetase; Provisional; Region: PRK09194
546342003606	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
546342003607	dimer interface [polypeptide binding]; other site
546342003608	motif 1; other site
546342003609	active site
546342003610	motif 2; other site
546342003611	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
546342003612	putative deacylase active site [active]
546342003613	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
546342003614	active site
546342003615	motif 3; other site
546342003616	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
546342003617	anticodon binding site; other site
546342003618	DNA polymerase III PolC; Validated; Region: polC; PRK00448
546342003619	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
546342003620	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
546342003621	generic binding surface II; other site
546342003622	generic binding surface I; other site
546342003623	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
546342003624	active site
546342003625	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
546342003626	active site
546342003627	catalytic site [active]
546342003628	substrate binding site [chemical binding]; other site
546342003629	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
546342003630	ribosome maturation protein RimP; Reviewed; Region: PRK00092
546342003631	Sm and related proteins; Region: Sm_like; cl00259
546342003632	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
546342003633	putative oligomer interface [polypeptide binding]; other site
546342003634	putative RNA binding site [nucleotide binding]; other site
546342003635	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
546342003636	NusA N-terminal domain; Region: NusA_N; pfam08529
546342003637	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
546342003638	RNA binding site [nucleotide binding]; other site
546342003639	homodimer interface [polypeptide binding]; other site
546342003640	NusA-like KH domain; Region: KH_5; pfam13184
546342003641	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
546342003642	G-X-X-G motif; other site
546342003643	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
546342003644	putative RNA binding cleft [nucleotide binding]; other site
546342003645	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
546342003646	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
546342003647	translation initiation factor IF-2; Region: IF-2; TIGR00487
546342003648	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
546342003649	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
546342003650	G1 box; other site
546342003651	putative GEF interaction site [polypeptide binding]; other site
546342003652	GTP/Mg2+ binding site [chemical binding]; other site
546342003653	Switch I region; other site
546342003654	G2 box; other site
546342003655	G3 box; other site
546342003656	Switch II region; other site
546342003657	G4 box; other site
546342003658	G5 box; other site
546342003659	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
546342003660	Translation-initiation factor 2; Region: IF-2; pfam11987
546342003661	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
546342003662	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
546342003663	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
546342003664	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
546342003665	RNA binding site [nucleotide binding]; other site
546342003666	active site
546342003667	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
546342003668	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
546342003669	active site
546342003670	Riboflavin kinase; Region: Flavokinase; smart00904
546342003671	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
546342003672	16S/18S rRNA binding site [nucleotide binding]; other site
546342003673	S13e-L30e interaction site [polypeptide binding]; other site
546342003674	25S rRNA binding site [nucleotide binding]; other site
546342003675	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
546342003676	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
546342003677	RNase E interface [polypeptide binding]; other site
546342003678	trimer interface [polypeptide binding]; other site
546342003679	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
546342003680	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
546342003681	RNase E interface [polypeptide binding]; other site
546342003682	trimer interface [polypeptide binding]; other site
546342003683	active site
546342003684	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
546342003685	putative nucleic acid binding region [nucleotide binding]; other site
546342003686	G-X-X-G motif; other site
546342003687	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
546342003688	RNA binding site [nucleotide binding]; other site
546342003689	domain interface; other site
546342003690	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
546342003691	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546342003692	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
546342003693	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
546342003694	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
546342003695	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
546342003696	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
546342003697	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
546342003698	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
546342003699	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
546342003700	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
546342003701	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
546342003702	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
546342003703	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
546342003704	classical (c) SDRs; Region: SDR_c; cd05233
546342003705	NAD(P) binding site [chemical binding]; other site
546342003706	active site
546342003707	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
546342003708	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
546342003709	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
546342003710	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342003711	non-specific DNA binding site [nucleotide binding]; other site
546342003712	salt bridge; other site
546342003713	sequence-specific DNA binding site [nucleotide binding]; other site
546342003714	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
546342003715	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
546342003716	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
546342003717	putative MPT binding site; other site
546342003718	recombinase A; Provisional; Region: recA; PRK09354
546342003719	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
546342003720	hexamer interface [polypeptide binding]; other site
546342003721	Walker A motif; other site
546342003722	ATP binding site [chemical binding]; other site
546342003723	Walker B motif; other site
546342003724	phosphodiesterase; Provisional; Region: PRK12704
546342003725	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546342003726	Zn2+ binding site [ion binding]; other site
546342003727	Mg2+ binding site [ion binding]; other site
546342003728	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
546342003729	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
546342003730	putative active site [active]
546342003731	metal binding site [ion binding]; metal-binding site
546342003732	homodimer binding site [polypeptide binding]; other site
546342003733	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
546342003734	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
546342003735	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
546342003736	dimer interface [polypeptide binding]; other site
546342003737	PYR/PP interface [polypeptide binding]; other site
546342003738	TPP binding site [chemical binding]; other site
546342003739	substrate binding site [chemical binding]; other site
546342003740	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
546342003741	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
546342003742	TPP-binding site [chemical binding]; other site
546342003743	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
546342003744	Uncharacterized conserved protein [Function unknown]; Region: COG0011
546342003745	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
546342003746	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
546342003747	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546342003748	FeS/SAM binding site; other site
546342003749	TRAM domain; Region: TRAM; pfam01938
546342003750	Predicted membrane protein [Function unknown]; Region: COG4550
546342003751	Predicted membrane protein [Function unknown]; Region: COG4732
546342003752	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
546342003753	MutS domain I; Region: MutS_I; pfam01624
546342003754	MutS domain II; Region: MutS_II; pfam05188
546342003755	MutS domain III; Region: MutS_III; pfam05192
546342003756	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
546342003757	Walker A/P-loop; other site
546342003758	ATP binding site [chemical binding]; other site
546342003759	Q-loop/lid; other site
546342003760	ABC transporter signature motif; other site
546342003761	Walker B; other site
546342003762	D-loop; other site
546342003763	H-loop/switch region; other site
546342003764	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
546342003765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342003766	ATP binding site [chemical binding]; other site
546342003767	Mg2+ binding site [ion binding]; other site
546342003768	G-X-G motif; other site
546342003769	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
546342003770	ATP binding site [chemical binding]; other site
546342003771	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
546342003772	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
546342003773	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
546342003774	amphipathic channel; other site
546342003775	Asn-Pro-Ala signature motifs; other site
546342003776	glycerol kinase; Provisional; Region: glpK; PRK00047
546342003777	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
546342003778	N- and C-terminal domain interface [polypeptide binding]; other site
546342003779	active site
546342003780	MgATP binding site [chemical binding]; other site
546342003781	catalytic site [active]
546342003782	metal binding site [ion binding]; metal-binding site
546342003783	glycerol binding site [chemical binding]; other site
546342003784	homotetramer interface [polypeptide binding]; other site
546342003785	homodimer interface [polypeptide binding]; other site
546342003786	FBP binding site [chemical binding]; other site
546342003787	protein IIAGlc interface [polypeptide binding]; other site
546342003788	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
546342003789	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
546342003790	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546342003791	Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209
546342003792	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
546342003793	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
546342003794	bacterial Hfq-like; Region: Hfq; cd01716
546342003795	hexamer interface [polypeptide binding]; other site
546342003796	Sm1 motif; other site
546342003797	RNA binding site [nucleotide binding]; other site
546342003798	Sm2 motif; other site
546342003799	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
546342003800	catalytic residues [active]
546342003801	dimer interface [polypeptide binding]; other site
546342003802	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
546342003803	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
546342003804	HflX GTPase family; Region: HflX; cd01878
546342003805	G1 box; other site
546342003806	GTP/Mg2+ binding site [chemical binding]; other site
546342003807	Switch I region; other site
546342003808	G2 box; other site
546342003809	G3 box; other site
546342003810	Switch II region; other site
546342003811	G4 box; other site
546342003812	G5 box; other site
546342003813	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
546342003814	Aluminium resistance protein; Region: Alum_res; pfam06838
546342003815	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
546342003816	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
546342003817	DNA binding residues [nucleotide binding]
546342003818	putative dimer interface [polypeptide binding]; other site
546342003819	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
546342003820	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
546342003821	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
546342003822	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342003823	MULE transposase domain; Region: MULE; pfam10551
546342003824	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
546342003825	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
546342003826	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
546342003827	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
546342003828	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
546342003829	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546342003830	catalytic residue [active]
546342003831	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
546342003832	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
546342003833	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
546342003834	putative active site [active]
546342003835	catalytic site [active]
546342003836	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
546342003837	putative active site [active]
546342003838	catalytic site [active]
546342003839	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
546342003840	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
546342003841	Walker A/P-loop; other site
546342003842	ATP binding site [chemical binding]; other site
546342003843	Q-loop/lid; other site
546342003844	ABC transporter signature motif; other site
546342003845	Walker B; other site
546342003846	D-loop; other site
546342003847	H-loop/switch region; other site
546342003848	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
546342003849	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
546342003850	Histidine kinase; Region: HisKA_3; pfam07730
546342003851	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
546342003852	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546342003853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342003854	active site
546342003855	phosphorylation site [posttranslational modification]
546342003856	intermolecular recognition site; other site
546342003857	dimerization interface [polypeptide binding]; other site
546342003858	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546342003859	DNA binding residues [nucleotide binding]
546342003860	dimerization interface [polypeptide binding]; other site
546342003861	Staphylococcal nuclease homologues; Region: SNc; smart00318
546342003862	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
546342003863	Catalytic site; other site
546342003864	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342003865	MULE transposase domain; Region: MULE; pfam10551
546342003866	AAA domain; Region: AAA_11; pfam13086
546342003867	aspartate kinase; Reviewed; Region: PRK09034
546342003868	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
546342003869	putative catalytic residues [active]
546342003870	putative nucleotide binding site [chemical binding]; other site
546342003871	putative aspartate binding site [chemical binding]; other site
546342003872	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
546342003873	allosteric regulatory residue; other site
546342003874	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
546342003875	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
546342003876	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
546342003877	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
546342003878	threonine synthase; Reviewed; Region: PRK06721
546342003879	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
546342003880	homodimer interface [polypeptide binding]; other site
546342003881	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342003882	catalytic residue [active]
546342003883	homoserine kinase; Provisional; Region: PRK01212
546342003884	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
546342003885	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
546342003886	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342003887	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
546342003888	active site
546342003889	motif I; other site
546342003890	motif II; other site
546342003891	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
546342003892	lysine transporter; Provisional; Region: PRK10836
546342003893	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
546342003894	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
546342003895	tetramer interface [polypeptide binding]; other site
546342003896	heme binding pocket [chemical binding]; other site
546342003897	NADPH binding site [chemical binding]; other site
546342003898	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
546342003899	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
546342003900	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
546342003901	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
546342003902	active site
546342003903	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
546342003904	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
546342003905	LexA repressor; Validated; Region: PRK00215
546342003906	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546342003907	putative DNA binding site [nucleotide binding]; other site
546342003908	putative Zn2+ binding site [ion binding]; other site
546342003909	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
546342003910	Catalytic site [active]
546342003911	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
546342003912	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
546342003913	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
546342003914	TPP-binding site [chemical binding]; other site
546342003915	dimer interface [polypeptide binding]; other site
546342003916	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
546342003917	PYR/PP interface [polypeptide binding]; other site
546342003918	dimer interface [polypeptide binding]; other site
546342003919	TPP binding site [chemical binding]; other site
546342003920	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
546342003921	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
546342003922	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
546342003923	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
546342003924	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
546342003925	active site
546342003926	metal binding site [ion binding]; metal-binding site
546342003927	DNA binding site [nucleotide binding]
546342003928	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
546342003929	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
546342003930	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
546342003931	Walker A/P-loop; other site
546342003932	ATP binding site [chemical binding]; other site
546342003933	Q-loop/lid; other site
546342003934	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
546342003935	ABC transporter signature motif; other site
546342003936	Walker B; other site
546342003937	D-loop; other site
546342003938	H-loop/switch region; other site
546342003939	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
546342003940	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954
546342003941	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
546342003942	aconitate hydratase; Validated; Region: PRK09277
546342003943	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
546342003944	substrate binding site [chemical binding]; other site
546342003945	ligand binding site [chemical binding]; other site
546342003946	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
546342003947	substrate binding site [chemical binding]; other site
546342003948	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
546342003949	active site
546342003950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
546342003951	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
546342003952	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
546342003953	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342003954	ATP binding site [chemical binding]; other site
546342003955	Mg2+ binding site [ion binding]; other site
546342003956	G-X-G motif; other site
546342003957	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
546342003958	anchoring element; other site
546342003959	dimer interface [polypeptide binding]; other site
546342003960	ATP binding site [chemical binding]; other site
546342003961	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
546342003962	active site
546342003963	putative metal-binding site [ion binding]; other site
546342003964	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
546342003965	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
546342003966	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
546342003967	CAP-like domain; other site
546342003968	active site
546342003969	primary dimer interface [polypeptide binding]; other site
546342003970	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
546342003971	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
546342003972	amino acid carrier protein; Region: agcS; TIGR00835
546342003973	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342003974	MULE transposase domain; Region: MULE; pfam10551
546342003975	CAT RNA binding domain; Region: CAT_RBD; smart01061
546342003976	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
546342003977	PRD domain; Region: PRD; pfam00874
546342003978	PRD domain; Region: PRD; pfam00874
546342003979	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
546342003980	Domain of unknown function DUF20; Region: UPF0118; pfam01594
546342003981	Predicted integral membrane protein [Function unknown]; Region: COG0392
546342003982	Uncharacterized conserved protein [Function unknown]; Region: COG2898
546342003983	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
546342003984	methionine sulfoxide reductase A; Provisional; Region: PRK14054
546342003985	Transcriptional regulator [Transcription]; Region: LytR; COG1316
546342003986	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
546342003987	active site 1 [active]
546342003988	dimer interface [polypeptide binding]; other site
546342003989	hexamer interface [polypeptide binding]; other site
546342003990	active site 2 [active]
546342003991	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
546342003992	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
546342003993	active site
546342003994	DNA binding site [nucleotide binding]
546342003995	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
546342003996	prephenate dehydrogenase; Validated; Region: PRK06545
546342003997	prephenate dehydrogenase; Validated; Region: PRK08507
546342003998	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
546342003999	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
546342004000	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
546342004001	putative oligomer interface [polypeptide binding]; other site
546342004002	putative active site [active]
546342004003	metal binding site [ion binding]; metal-binding site
546342004004	anthranilate synthase component I; Provisional; Region: PRK13567
546342004005	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
546342004006	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
546342004007	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
546342004008	Glutamine amidotransferase class-I; Region: GATase; pfam00117
546342004009	glutamine binding [chemical binding]; other site
546342004010	catalytic triad [active]
546342004011	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
546342004012	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
546342004013	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
546342004014	active site
546342004015	ribulose/triose binding site [chemical binding]; other site
546342004016	phosphate binding site [ion binding]; other site
546342004017	substrate (anthranilate) binding pocket [chemical binding]; other site
546342004018	product (indole) binding pocket [chemical binding]; other site
546342004019	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
546342004020	active site
546342004021	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
546342004022	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
546342004023	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342004024	catalytic residue [active]
546342004025	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
546342004026	substrate binding site [chemical binding]; other site
546342004027	active site
546342004028	catalytic residues [active]
546342004029	heterodimer interface [polypeptide binding]; other site
546342004030	FemAB family; Region: FemAB; pfam02388
546342004031	FlxA-like protein; Region: FlxA; pfam14282
546342004032	FemAB family; Region: FemAB; pfam02388
546342004033	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
546342004034	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342004035	active site
546342004036	motif I; other site
546342004037	motif II; other site
546342004038	SWIM zinc finger; Region: SWIM; pfam04434
546342004039	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
546342004040	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546342004041	Walker A/P-loop; other site
546342004042	ATP binding site [chemical binding]; other site
546342004043	Q-loop/lid; other site
546342004044	ABC transporter signature motif; other site
546342004045	Walker B; other site
546342004046	D-loop; other site
546342004047	H-loop/switch region; other site
546342004048	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546342004049	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
546342004050	Walker A/P-loop; other site
546342004051	ATP binding site [chemical binding]; other site
546342004052	Q-loop/lid; other site
546342004053	ABC transporter signature motif; other site
546342004054	Walker B; other site
546342004055	D-loop; other site
546342004056	H-loop/switch region; other site
546342004057	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546342004058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342004059	dimer interface [polypeptide binding]; other site
546342004060	conserved gate region; other site
546342004061	putative PBP binding loops; other site
546342004062	ABC-ATPase subunit interface; other site
546342004063	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546342004064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342004065	dimer interface [polypeptide binding]; other site
546342004066	conserved gate region; other site
546342004067	putative PBP binding loops; other site
546342004068	ABC-ATPase subunit interface; other site
546342004069	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
546342004070	oligoendopeptidase F; Region: pepF; TIGR00181
546342004071	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
546342004072	active site
546342004073	Zn binding site [ion binding]; other site
546342004074	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
546342004075	PhoU domain; Region: PhoU; pfam01895
546342004076	PhoU domain; Region: PhoU; pfam01895
546342004077	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
546342004078	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
546342004079	Walker A/P-loop; other site
546342004080	ATP binding site [chemical binding]; other site
546342004081	Q-loop/lid; other site
546342004082	ABC transporter signature motif; other site
546342004083	Walker B; other site
546342004084	D-loop; other site
546342004085	H-loop/switch region; other site
546342004086	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
546342004087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342004088	dimer interface [polypeptide binding]; other site
546342004089	conserved gate region; other site
546342004090	putative PBP binding loops; other site
546342004091	ABC-ATPase subunit interface; other site
546342004092	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
546342004093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342004094	dimer interface [polypeptide binding]; other site
546342004095	conserved gate region; other site
546342004096	ABC-ATPase subunit interface; other site
546342004097	phosphate binding protein; Region: ptsS_2; TIGR02136
546342004098	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
546342004099	S1 domain; Region: S1_2; pfam13509
546342004100	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
546342004101	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546342004102	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546342004103	ABC transporter; Region: ABC_tran_2; pfam12848
546342004104	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546342004105	aspartate kinase; Reviewed; Region: PRK06635
546342004106	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
546342004107	putative Mg ion binding site [ion binding]; other site
546342004108	putative aspartate binding site [chemical binding]; other site
546342004109	putative catalytic residues [active]
546342004110	putative nucleotide binding site [chemical binding]; other site
546342004111	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
546342004112	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
546342004113	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
546342004114	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
546342004115	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
546342004116	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
546342004117	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
546342004118	dimer interface [polypeptide binding]; other site
546342004119	active site
546342004120	catalytic residue [active]
546342004121	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
546342004122	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
546342004123	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
546342004124	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
546342004125	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
546342004126	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
546342004127	active site
546342004128	trimer interface [polypeptide binding]; other site
546342004129	substrate binding site [chemical binding]; other site
546342004130	CoA binding site [chemical binding]; other site
546342004131	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
546342004132	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
546342004133	metal binding site [ion binding]; metal-binding site
546342004134	dimer interface [polypeptide binding]; other site
546342004135	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
546342004136	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
546342004137	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546342004138	catalytic residue [active]
546342004139	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
546342004140	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
546342004141	active site
546342004142	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546342004143	substrate binding site [chemical binding]; other site
546342004144	catalytic residues [active]
546342004145	dimer interface [polypeptide binding]; other site
546342004146	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
546342004147	DNA-binding site [nucleotide binding]; DNA binding site
546342004148	RNA-binding motif; other site
546342004149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699
546342004150	acylphosphatase; Provisional; Region: PRK14431
546342004151	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
546342004152	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
546342004153	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
546342004154	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
546342004155	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
546342004156	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
546342004157	metal ion-dependent adhesion site (MIDAS); other site
546342004158	MoxR-like ATPases [General function prediction only]; Region: COG0714
546342004159	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342004160	Walker A motif; other site
546342004161	ATP binding site [chemical binding]; other site
546342004162	Walker B motif; other site
546342004163	arginine finger; other site
546342004164	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
546342004165	active site
546342004166	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
546342004167	active site
546342004168	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
546342004169	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
546342004170	E3 interaction surface; other site
546342004171	lipoyl attachment site [posttranslational modification]; other site
546342004172	e3 binding domain; Region: E3_binding; pfam02817
546342004173	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
546342004174	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
546342004175	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
546342004176	TPP-binding site [chemical binding]; other site
546342004177	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
546342004178	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
546342004179	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546342004180	HAMP domain; Region: HAMP; pfam00672
546342004181	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546342004182	dimer interface [polypeptide binding]; other site
546342004183	phosphorylation site [posttranslational modification]
546342004184	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342004185	ATP binding site [chemical binding]; other site
546342004186	Mg2+ binding site [ion binding]; other site
546342004187	G-X-G motif; other site
546342004188	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546342004189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342004190	active site
546342004191	phosphorylation site [posttranslational modification]
546342004192	intermolecular recognition site; other site
546342004193	dimerization interface [polypeptide binding]; other site
546342004194	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546342004195	DNA binding site [nucleotide binding]
546342004196	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342004197	MULE transposase domain; Region: MULE; pfam10551
546342004198	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
546342004199	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
546342004200	active site
546342004201	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
546342004202	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
546342004203	active site
546342004204	homodimer interface [polypeptide binding]; other site
546342004205	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
546342004206	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342004207	Coenzyme A binding pocket [chemical binding]; other site
546342004208	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
546342004209	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
546342004210	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
546342004211	protein binding site [polypeptide binding]; other site
546342004212	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
546342004213	Catalytic dyad [active]
546342004214	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
546342004215	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479
546342004216	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
546342004217	HPr interaction site; other site
546342004218	glycerol kinase (GK) interaction site [polypeptide binding]; other site
546342004219	active site
546342004220	phosphorylation site [posttranslational modification]
546342004221	methionine sulfoxide reductase B; Provisional; Region: PRK00222
546342004222	SelR domain; Region: SelR; pfam01641
546342004223	methionine sulfoxide reductase A; Provisional; Region: PRK13014
546342004224	EDD domain protein, DegV family; Region: DegV; TIGR00762
546342004225	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
546342004226	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
546342004227	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
546342004228	folate binding site [chemical binding]; other site
546342004229	NADP+ binding site [chemical binding]; other site
546342004230	thymidylate synthase; Region: thym_sym; TIGR03284
546342004231	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
546342004232	dimerization interface [polypeptide binding]; other site
546342004233	active site
546342004234	Disulphide isomerase; Region: Disulph_isomer; pfam06491
546342004235	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
546342004236	Virulence factor; Region: Virulence_fact; pfam13769
546342004237	HEAT repeats; Region: HEAT_2; pfam13646
546342004238	HEAT repeat; Region: HEAT; pfam02985
546342004239	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
546342004240	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
546342004241	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
546342004242	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
546342004243	RNA/DNA hybrid binding site [nucleotide binding]; other site
546342004244	active site
546342004245	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
546342004246	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
546342004247	GA module; Region: GA; smart00844
546342004248	GA module; Region: GA; smart00844
546342004249	GA module; Region: GA; smart00844
546342004250	GA module; Region: GA; smart00844
546342004251	GA module; Region: GA; smart00844
546342004252	GA module; Region: GA; smart00844
546342004253	GA module; Region: GA; smart00844
546342004254	GA module; Region: GA; smart00844
546342004255	GA module; Region: GA; smart00844
546342004256	GA module; Region: GA; smart00844
546342004257	GA module; Region: GA; smart00844
546342004258	GA module; Region: GA; smart00844
546342004259	GA module; Region: GA; smart00844
546342004260	GA module; Region: GA; smart00844
546342004261	GA module; Region: GA; smart00844
546342004262	GA module; Region: GA; smart00844
546342004263	GA module; Region: GA; smart00844
546342004264	GA module; Region: GA; smart00844
546342004265	GA module; Region: GA; smart00844
546342004266	GA module; Region: GA; pfam01468
546342004267	GA module; Region: GA; smart00844
546342004268	GA module; Region: GA; smart00844
546342004269	GA module; Region: GA; smart00844
546342004270	GA module; Region: GA; smart00844
546342004271	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
546342004272	GA module; Region: GA; smart00844
546342004273	GA module; Region: GA; smart00844
546342004274	GA module; Region: GA; smart00844
546342004275	GA module; Region: GA; smart00844
546342004276	GA module; Region: GA; smart00844
546342004277	GA module; Region: GA; smart00844
546342004278	GA module; Region: GA; smart00844
546342004279	GA module; Region: GA; pfam01468
546342004280	GA module; Region: GA; smart00844
546342004281	GA module; Region: GA; smart00844
546342004282	GA module; Region: GA; smart00844
546342004283	GA module; Region: GA; smart00844
546342004284	GA module; Region: GA; smart00844
546342004285	GA module; Region: GA; smart00844
546342004286	GA module; Region: GA; smart00844
546342004287	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
546342004288	GA module; Region: GA; smart00844
546342004289	GA module; Region: GA; smart00844
546342004290	GA module; Region: GA; smart00844
546342004291	GA module; Region: GA; smart00844
546342004292	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342004293	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342004294	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
546342004295	Amino acid permease; Region: AA_permease_2; pfam13520
546342004296	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
546342004297	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
546342004298	tetramer interface [polypeptide binding]; other site
546342004299	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342004300	catalytic residue [active]
546342004301	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
546342004302	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
546342004303	hexamer interface [polypeptide binding]; other site
546342004304	ligand binding site [chemical binding]; other site
546342004305	putative active site [active]
546342004306	NAD(P) binding site [chemical binding]; other site
546342004307	5'-3' exonuclease; Region: 53EXOc; smart00475
546342004308	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
546342004309	active site
546342004310	metal binding site 1 [ion binding]; metal-binding site
546342004311	putative 5' ssDNA interaction site; other site
546342004312	metal binding site 3; metal-binding site
546342004313	metal binding site 2 [ion binding]; metal-binding site
546342004314	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
546342004315	putative DNA binding site [nucleotide binding]; other site
546342004316	putative metal binding site [ion binding]; other site
546342004317	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
546342004318	Dynamin family; Region: Dynamin_N; pfam00350
546342004319	G1 box; other site
546342004320	GTP/Mg2+ binding site [chemical binding]; other site
546342004321	G2 box; other site
546342004322	Switch I region; other site
546342004323	G3 box; other site
546342004324	Switch II region; other site
546342004325	G4 box; other site
546342004326	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
546342004327	Dynamin family; Region: Dynamin_N; pfam00350
546342004328	G1 box; other site
546342004329	GTP/Mg2+ binding site [chemical binding]; other site
546342004330	G2 box; other site
546342004331	Switch I region; other site
546342004332	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
546342004333	G3 box; other site
546342004334	Switch II region; other site
546342004335	GTP/Mg2+ binding site [chemical binding]; other site
546342004336	G4 box; other site
546342004337	G5 box; other site
546342004338	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
546342004339	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
546342004340	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
546342004341	Cobalt transport protein component CbiN; Region: CbiN; cl00842
546342004342	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
546342004343	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
546342004344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
546342004345	cell division protein GpsB; Provisional; Region: PRK14127
546342004346	DivIVA domain; Region: DivI1A_domain; TIGR03544
546342004347	hypothetical protein; Provisional; Region: PRK13660
546342004348	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
546342004349	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
546342004350	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
546342004351	Transglycosylase; Region: Transgly; pfam00912
546342004352	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
546342004353	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
546342004354	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546342004355	minor groove reading motif; other site
546342004356	helix-hairpin-helix signature motif; other site
546342004357	substrate binding pocket [chemical binding]; other site
546342004358	active site
546342004359	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
546342004360	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
546342004361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
546342004362	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
546342004363	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
546342004364	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
546342004365	putative dimer interface [polypeptide binding]; other site
546342004366	putative anticodon binding site; other site
546342004367	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
546342004368	homodimer interface [polypeptide binding]; other site
546342004369	motif 1; other site
546342004370	motif 2; other site
546342004371	active site
546342004372	motif 3; other site
546342004373	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
546342004374	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
546342004375	active site
546342004376	catalytic site [active]
546342004377	substrate binding site [chemical binding]; other site
546342004378	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
546342004379	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
546342004380	Biotin operon repressor [Transcription]; Region: BirA; COG1654
546342004381	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
546342004382	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
546342004383	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
546342004384	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
546342004385	active site
546342004386	NTP binding site [chemical binding]; other site
546342004387	metal binding triad [ion binding]; metal-binding site
546342004388	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
546342004389	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
546342004390	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
546342004391	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
546342004392	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
546342004393	homodimer interface [polypeptide binding]; other site
546342004394	metal binding site [ion binding]; metal-binding site
546342004395	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
546342004396	Predicted membrane protein [Function unknown]; Region: COG4347
546342004397	Uncharacterized conserved protein [Function unknown]; Region: COG5582
546342004398	UPF0302 domain; Region: UPF0302; pfam08864
546342004399	A short protein domain of unknown function; Region: IDEAL; smart00914
546342004400	TPR repeat; Region: TPR_11; pfam13414
546342004401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546342004402	binding surface
546342004403	TPR motif; other site
546342004404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546342004405	TPR motif; other site
546342004406	binding surface
546342004407	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
546342004408	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
546342004409	hinge; other site
546342004410	active site
546342004411	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
546342004412	active site
546342004413	NAD binding site [chemical binding]; other site
546342004414	metal binding site [ion binding]; metal-binding site
546342004415	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
546342004416	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
546342004417	Tetramer interface [polypeptide binding]; other site
546342004418	active site
546342004419	FMN-binding site [chemical binding]; other site
546342004420	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
546342004421	active site
546342004422	multimer interface [polypeptide binding]; other site
546342004423	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
546342004424	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
546342004425	substrate binding pocket [chemical binding]; other site
546342004426	chain length determination region; other site
546342004427	substrate-Mg2+ binding site; other site
546342004428	catalytic residues [active]
546342004429	aspartate-rich region 1; other site
546342004430	active site lid residues [active]
546342004431	aspartate-rich region 2; other site
546342004432	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
546342004433	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342004434	S-adenosylmethionine binding site [chemical binding]; other site
546342004435	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
546342004436	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
546342004437	IHF dimer interface [polypeptide binding]; other site
546342004438	IHF - DNA interface [nucleotide binding]; other site
546342004439	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
546342004440	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
546342004441	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
546342004442	GTP-binding protein Der; Reviewed; Region: PRK00093
546342004443	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
546342004444	G1 box; other site
546342004445	GTP/Mg2+ binding site [chemical binding]; other site
546342004446	Switch I region; other site
546342004447	G2 box; other site
546342004448	Switch II region; other site
546342004449	G3 box; other site
546342004450	G4 box; other site
546342004451	G5 box; other site
546342004452	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
546342004453	G1 box; other site
546342004454	GTP/Mg2+ binding site [chemical binding]; other site
546342004455	Switch I region; other site
546342004456	G2 box; other site
546342004457	G3 box; other site
546342004458	Switch II region; other site
546342004459	G4 box; other site
546342004460	G5 box; other site
546342004461	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
546342004462	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
546342004463	RNA binding site [nucleotide binding]; other site
546342004464	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
546342004465	RNA binding site [nucleotide binding]; other site
546342004466	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
546342004467	RNA binding site [nucleotide binding]; other site
546342004468	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
546342004469	RNA binding site [nucleotide binding]; other site
546342004470	cytidylate kinase; Provisional; Region: cmk; PRK00023
546342004471	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
546342004472	CMP-binding site; other site
546342004473	The sites determining sugar specificity; other site
546342004474	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
546342004475	active site
546342004476	homodimer interface [polypeptide binding]; other site
546342004477	homotetramer interface [polypeptide binding]; other site
546342004478	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
546342004479	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
546342004480	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342004481	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
546342004482	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
546342004483	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546342004484	ATP binding site [chemical binding]; other site
546342004485	putative Mg++ binding site [ion binding]; other site
546342004486	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546342004487	nucleotide binding region [chemical binding]; other site
546342004488	ATP-binding site [chemical binding]; other site
546342004489	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
546342004490	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
546342004491	Predicted membrane protein [Function unknown]; Region: COG3601
546342004492	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
546342004493	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
546342004494	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
546342004495	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
546342004496	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
546342004497	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546342004498	dimerization interface [polypeptide binding]; other site
546342004499	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
546342004500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546342004501	dimer interface [polypeptide binding]; other site
546342004502	phosphorylation site [posttranslational modification]
546342004503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342004504	ATP binding site [chemical binding]; other site
546342004505	Mg2+ binding site [ion binding]; other site
546342004506	G-X-G motif; other site
546342004507	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546342004508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342004509	active site
546342004510	phosphorylation site [posttranslational modification]
546342004511	intermolecular recognition site; other site
546342004512	dimerization interface [polypeptide binding]; other site
546342004513	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546342004514	DNA binding site [nucleotide binding]
546342004515	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
546342004516	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546342004517	RNA binding surface [nucleotide binding]; other site
546342004518	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
546342004519	active site
546342004520	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
546342004521	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
546342004522	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
546342004523	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
546342004524	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
546342004525	active site
546342004526	Int/Topo IB signature motif; other site
546342004527	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
546342004528	metal binding site 2 [ion binding]; metal-binding site
546342004529	putative DNA binding helix; other site
546342004530	metal binding site 1 [ion binding]; metal-binding site
546342004531	dimer interface [polypeptide binding]; other site
546342004532	structural Zn2+ binding site [ion binding]; other site
546342004533	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
546342004534	dimer interface [polypeptide binding]; other site
546342004535	ADP-ribose binding site [chemical binding]; other site
546342004536	active site
546342004537	nudix motif; other site
546342004538	metal binding site [ion binding]; metal-binding site
546342004539	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546342004540	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546342004541	active site
546342004542	catalytic tetrad [active]
546342004543	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
546342004544	classical (c) SDRs; Region: SDR_c; cd05233
546342004545	NAD(P) binding site [chemical binding]; other site
546342004546	active site
546342004547	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
546342004548	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
546342004549	ribonuclease Z; Region: RNase_Z; TIGR02651
546342004550	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
546342004551	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
546342004552	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
546342004553	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
546342004554	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
546342004555	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
546342004556	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
546342004557	Ca binding site [ion binding]; other site
546342004558	active site
546342004559	catalytic site [active]
546342004560	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546342004561	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546342004562	DNA binding site [nucleotide binding]
546342004563	domain linker motif; other site
546342004564	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
546342004565	putative ligand binding site [chemical binding]; other site
546342004566	putative dimerization interface [polypeptide binding]; other site
546342004567	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546342004568	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
546342004569	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
546342004570	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
546342004571	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
546342004572	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
546342004573	peptidase T-like protein; Region: PepT-like; TIGR01883
546342004574	metal binding site [ion binding]; metal-binding site
546342004575	putative dimer interface [polypeptide binding]; other site
546342004576	Predicted membrane protein [Function unknown]; Region: COG4129
546342004577	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
546342004578	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
546342004579	Disulphide isomerase; Region: Disulph_isomer; pfam06491
546342004580	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
546342004581	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
546342004582	E3 interaction surface; other site
546342004583	lipoyl attachment site [posttranslational modification]; other site
546342004584	e3 binding domain; Region: E3_binding; pfam02817
546342004585	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
546342004586	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
546342004587	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
546342004588	alpha subunit interface [polypeptide binding]; other site
546342004589	TPP binding site [chemical binding]; other site
546342004590	heterodimer interface [polypeptide binding]; other site
546342004591	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
546342004592	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
546342004593	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
546342004594	tetramer interface [polypeptide binding]; other site
546342004595	TPP-binding site [chemical binding]; other site
546342004596	heterodimer interface [polypeptide binding]; other site
546342004597	phosphorylation loop region [posttranslational modification]
546342004598	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
546342004599	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
546342004600	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342004601	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
546342004602	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
546342004603	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
546342004604	Walker A/P-loop; other site
546342004605	ATP binding site [chemical binding]; other site
546342004606	Q-loop/lid; other site
546342004607	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
546342004608	ABC transporter signature motif; other site
546342004609	Walker B; other site
546342004610	D-loop; other site
546342004611	H-loop/switch region; other site
546342004612	arginine repressor; Provisional; Region: PRK04280
546342004613	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
546342004614	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
546342004615	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
546342004616	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
546342004617	substrate binding pocket [chemical binding]; other site
546342004618	chain length determination region; other site
546342004619	substrate-Mg2+ binding site; other site
546342004620	catalytic residues [active]
546342004621	aspartate-rich region 1; other site
546342004622	active site lid residues [active]
546342004623	aspartate-rich region 2; other site
546342004624	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068
546342004625	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
546342004626	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
546342004627	generic binding surface II; other site
546342004628	generic binding surface I; other site
546342004629	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
546342004630	putative RNA binding site [nucleotide binding]; other site
546342004631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
546342004632	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
546342004633	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546342004634	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
546342004635	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
546342004636	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
546342004637	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
546342004638	carboxyltransferase (CT) interaction site; other site
546342004639	biotinylation site [posttranslational modification]; other site
546342004640	elongation factor P; Validated; Region: PRK00529
546342004641	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
546342004642	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
546342004643	RNA binding site [nucleotide binding]; other site
546342004644	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
546342004645	RNA binding site [nucleotide binding]; other site
546342004646	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
546342004647	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
546342004648	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
546342004649	active site
546342004650	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
546342004651	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
546342004652	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
546342004653	active site residue [active]
546342004654	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
546342004655	tetramer interface [polypeptide binding]; other site
546342004656	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342004657	catalytic residue [active]
546342004658	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
546342004659	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
546342004660	tetramer interface [polypeptide binding]; other site
546342004661	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342004662	catalytic residue [active]
546342004663	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
546342004664	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
546342004665	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
546342004666	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
546342004667	ADP binding site [chemical binding]; other site
546342004668	magnesium binding site [ion binding]; other site
546342004669	putative shikimate binding site; other site
546342004670	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
546342004671	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
546342004672	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
546342004673	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
546342004674	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
546342004675	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
546342004676	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
546342004677	Type II/IV secretion system protein; Region: T2SE; pfam00437
546342004678	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
546342004679	Walker A motif; other site
546342004680	ATP binding site [chemical binding]; other site
546342004681	Walker B motif; other site
546342004682	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546342004683	Uncharacterized conserved protein [Function unknown]; Region: COG0011
546342004684	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
546342004685	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
546342004686	Rhomboid family; Region: Rhomboid; pfam01694
546342004687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546342004688	binding surface
546342004689	TPR motif; other site
546342004690	Tetratricopeptide repeat; Region: TPR_16; pfam13432
546342004691	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
546342004692	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
546342004693	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
546342004694	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
546342004695	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
546342004696	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
546342004697	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
546342004698	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
546342004699	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
546342004700	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
546342004701	metal binding site 2 [ion binding]; metal-binding site
546342004702	putative DNA binding helix; other site
546342004703	metal binding site 1 [ion binding]; metal-binding site
546342004704	dimer interface [polypeptide binding]; other site
546342004705	structural Zn2+ binding site [ion binding]; other site
546342004706	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
546342004707	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342004708	ABC-ATPase subunit  interface; other site
546342004709	dimer interface [polypeptide binding]; other site
546342004710	putative PBP binding regions; other site
546342004711	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
546342004712	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
546342004713	endonuclease IV; Provisional; Region: PRK01060
546342004714	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
546342004715	AP (apurinic/apyrimidinic) site pocket; other site
546342004716	DNA interaction; other site
546342004717	Metal-binding active site; metal-binding site
546342004718	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
546342004719	DEAD-like helicases superfamily; Region: DEXDc; smart00487
546342004720	ATP binding site [chemical binding]; other site
546342004721	Mg++ binding site [ion binding]; other site
546342004722	motif III; other site
546342004723	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546342004724	nucleotide binding region [chemical binding]; other site
546342004725	ATP-binding site [chemical binding]; other site
546342004726	Uncharacterized conserved protein [Function unknown]; Region: COG0327
546342004727	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
546342004728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
546342004729	Uncharacterized conserved protein [Function unknown]; Region: COG0327
546342004730	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
546342004731	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
546342004732	Family of unknown function (DUF633); Region: DUF633; pfam04816
546342004733	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
546342004734	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
546342004735	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
546342004736	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546342004737	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
546342004738	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546342004739	DNA binding residues [nucleotide binding]
546342004740	DNA primase, catalytic core; Region: dnaG; TIGR01391
546342004741	CHC2 zinc finger; Region: zf-CHC2; pfam01807
546342004742	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
546342004743	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
546342004744	active site
546342004745	metal binding site [ion binding]; metal-binding site
546342004746	interdomain interaction site; other site
546342004747	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
546342004748	HTH domain; Region: HTH_11; cl17392
546342004749	FOG: CBS domain [General function prediction only]; Region: COG0517
546342004750	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
546342004751	glycyl-tRNA synthetase; Provisional; Region: PRK04173
546342004752	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
546342004753	motif 1; other site
546342004754	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
546342004755	active site
546342004756	motif 2; other site
546342004757	motif 3; other site
546342004758	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
546342004759	anticodon binding site; other site
546342004760	DNA repair protein RecO; Region: reco; TIGR00613
546342004761	Recombination protein O N terminal; Region: RecO_N; pfam11967
546342004762	Recombination protein O C terminal; Region: RecO_C; pfam02565
546342004763	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
546342004764	active site
546342004765	catalytic motif [active]
546342004766	Zn binding site [ion binding]; other site
546342004767	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
546342004768	metal-binding heat shock protein; Provisional; Region: PRK00016
546342004769	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
546342004770	PhoH-like protein; Region: PhoH; pfam02562
546342004771	hypothetical protein; Provisional; Region: PRK13665
546342004772	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
546342004773	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
546342004774	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
546342004775	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
546342004776	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546342004777	FeS/SAM binding site; other site
546342004778	TRAM domain; Region: TRAM; cl01282
546342004779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
546342004780	RNA methyltransferase, RsmE family; Region: TIGR00046
546342004781	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
546342004782	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342004783	S-adenosylmethionine binding site [chemical binding]; other site
546342004784	chaperone protein DnaJ; Provisional; Region: PRK14280
546342004785	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
546342004786	HSP70 interaction site [polypeptide binding]; other site
546342004787	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
546342004788	substrate binding site [polypeptide binding]; other site
546342004789	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
546342004790	Zn binding sites [ion binding]; other site
546342004791	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
546342004792	dimer interface [polypeptide binding]; other site
546342004793	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
546342004794	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
546342004795	nucleotide binding site [chemical binding]; other site
546342004796	NEF interaction site [polypeptide binding]; other site
546342004797	SBD interface [polypeptide binding]; other site
546342004798	heat shock protein GrpE; Provisional; Region: PRK14140
546342004799	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
546342004800	dimer interface [polypeptide binding]; other site
546342004801	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
546342004802	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
546342004803	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
546342004804	Tubulin C-terminal domain; Region: Tubulin_C; cl10021
546342004805	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
546342004806	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546342004807	FeS/SAM binding site; other site
546342004808	HemN C-terminal domain; Region: HemN_C; pfam06969
546342004809	GTP-binding protein LepA; Provisional; Region: PRK05433
546342004810	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
546342004811	G1 box; other site
546342004812	putative GEF interaction site [polypeptide binding]; other site
546342004813	GTP/Mg2+ binding site [chemical binding]; other site
546342004814	Switch I region; other site
546342004815	G2 box; other site
546342004816	G3 box; other site
546342004817	Switch II region; other site
546342004818	G4 box; other site
546342004819	G5 box; other site
546342004820	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
546342004821	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
546342004822	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
546342004823	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
546342004824	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
546342004825	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
546342004826	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
546342004827	Competence protein; Region: Competence; pfam03772
546342004828	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
546342004829	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
546342004830	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
546342004831	catalytic motif [active]
546342004832	Zn binding site [ion binding]; other site
546342004833	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
546342004834	SLBB domain; Region: SLBB; pfam10531
546342004835	Helix-hairpin-helix motif; Region: HHH; pfam00633
546342004836	Methyltransferase domain; Region: Methyltransf_31; pfam13847
546342004837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342004838	S-adenosylmethionine binding site [chemical binding]; other site
546342004839	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
546342004840	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546342004841	Zn2+ binding site [ion binding]; other site
546342004842	Mg2+ binding site [ion binding]; other site
546342004843	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
546342004844	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
546342004845	active site
546342004846	(T/H)XGH motif; other site
546342004847	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
546342004848	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
546342004849	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
546342004850	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
546342004851	shikimate binding site; other site
546342004852	NAD(P) binding site [chemical binding]; other site
546342004853	GTPase YqeH; Provisional; Region: PRK13796
546342004854	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
546342004855	GTP/Mg2+ binding site [chemical binding]; other site
546342004856	G4 box; other site
546342004857	G5 box; other site
546342004858	G1 box; other site
546342004859	Switch I region; other site
546342004860	G2 box; other site
546342004861	G3 box; other site
546342004862	Switch II region; other site
546342004863	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
546342004864	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342004865	active site
546342004866	motif I; other site
546342004867	motif II; other site
546342004868	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
546342004869	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
546342004870	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
546342004871	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342004872	Fic family protein [Function unknown]; Region: COG3177
546342004873	Fic/DOC family; Region: Fic; pfam02661
546342004874	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
546342004875	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
546342004876	putative active site [active]
546342004877	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
546342004878	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
546342004879	ATP-grasp domain; Region: ATP-grasp_4; cl17255
546342004880	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
546342004881	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
546342004882	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
546342004883	carboxyltransferase (CT) interaction site; other site
546342004884	biotinylation site [posttranslational modification]; other site
546342004885	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
546342004886	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
546342004887	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
546342004888	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
546342004889	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
546342004890	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
546342004891	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
546342004892	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
546342004893	Sugar specificity; other site
546342004894	Pyrimidine base specificity; other site
546342004895	ATP-binding site [chemical binding]; other site
546342004896	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
546342004897	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
546342004898	Peptidase family U32; Region: Peptidase_U32; pfam01136
546342004899	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
546342004900	Peptidase family U32; Region: Peptidase_U32; pfam01136
546342004901	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
546342004902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342004903	S-adenosylmethionine binding site [chemical binding]; other site
546342004904	hypothetical protein; Provisional; Region: PRK13678
546342004905	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
546342004906	hypothetical protein; Provisional; Region: PRK05473
546342004907	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
546342004908	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
546342004909	motif 1; other site
546342004910	active site
546342004911	motif 2; other site
546342004912	motif 3; other site
546342004913	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
546342004914	DHHA1 domain; Region: DHHA1; pfam02272
546342004915	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
546342004916	AAA domain; Region: AAA_30; pfam13604
546342004917	Family description; Region: UvrD_C_2; pfam13538
546342004918	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546342004919	binding surface
546342004920	TPR motif; other site
546342004921	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
546342004922	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
546342004923	binding surface
546342004924	TPR motif; other site
546342004925	TPR repeat; Region: TPR_11; pfam13414
546342004926	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
546342004927	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
546342004928	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
546342004929	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
546342004930	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546342004931	catalytic residue [active]
546342004932	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
546342004933	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
546342004934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
546342004935	Predicted transcriptional regulator [Transcription]; Region: COG1959
546342004936	Transcriptional regulator; Region: Rrf2; pfam02082
546342004937	recombination factor protein RarA; Reviewed; Region: PRK13342
546342004938	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342004939	Walker A motif; other site
546342004940	ATP binding site [chemical binding]; other site
546342004941	Walker B motif; other site
546342004942	arginine finger; other site
546342004943	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
546342004944	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
546342004945	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
546342004946	putative ATP binding site [chemical binding]; other site
546342004947	putative substrate interface [chemical binding]; other site
546342004948	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
546342004949	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
546342004950	dimer interface [polypeptide binding]; other site
546342004951	anticodon binding site; other site
546342004952	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
546342004953	homodimer interface [polypeptide binding]; other site
546342004954	motif 1; other site
546342004955	active site
546342004956	motif 2; other site
546342004957	GAD domain; Region: GAD; pfam02938
546342004958	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
546342004959	motif 3; other site
546342004960	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
546342004961	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
546342004962	dimer interface [polypeptide binding]; other site
546342004963	motif 1; other site
546342004964	active site
546342004965	motif 2; other site
546342004966	motif 3; other site
546342004967	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
546342004968	anticodon binding site; other site
546342004969	Bacterial SH3 domain homologues; Region: SH3b; smart00287
546342004970	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
546342004971	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
546342004972	active site
546342004973	metal binding site [ion binding]; metal-binding site
546342004974	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
546342004975	putative active site [active]
546342004976	dimerization interface [polypeptide binding]; other site
546342004977	putative tRNAtyr binding site [nucleotide binding]; other site
546342004978	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
546342004979	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546342004980	Zn2+ binding site [ion binding]; other site
546342004981	Mg2+ binding site [ion binding]; other site
546342004982	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
546342004983	synthetase active site [active]
546342004984	NTP binding site [chemical binding]; other site
546342004985	metal binding site [ion binding]; metal-binding site
546342004986	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
546342004987	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
546342004988	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546342004989	active site
546342004990	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
546342004991	DHH family; Region: DHH; pfam01368
546342004992	DHHA1 domain; Region: DHHA1; pfam02272
546342004993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
546342004994	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
546342004995	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
546342004996	Protein export membrane protein; Region: SecD_SecF; cl14618
546342004997	Protein export membrane protein; Region: SecD_SecF; pfam02355
546342004998	Preprotein translocase subunit; Region: YajC; pfam02699
546342004999	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
546342005000	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
546342005001	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
546342005002	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
546342005003	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
546342005004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342005005	Walker A motif; other site
546342005006	ATP binding site [chemical binding]; other site
546342005007	Walker B motif; other site
546342005008	arginine finger; other site
546342005009	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
546342005010	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
546342005011	RuvA N terminal domain; Region: RuvA_N; pfam01330
546342005012	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
546342005013	ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492
546342005014	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
546342005015	GTPase CgtA; Reviewed; Region: obgE; PRK12297
546342005016	GTP1/OBG; Region: GTP1_OBG; pfam01018
546342005017	Obg GTPase; Region: Obg; cd01898
546342005018	G1 box; other site
546342005019	GTP/Mg2+ binding site [chemical binding]; other site
546342005020	Switch I region; other site
546342005021	G2 box; other site
546342005022	G3 box; other site
546342005023	Switch II region; other site
546342005024	G4 box; other site
546342005025	G5 box; other site
546342005026	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
546342005027	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
546342005028	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
546342005029	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
546342005030	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
546342005031	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
546342005032	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
546342005033	rod shape-determining protein MreC; Region: MreC; pfam04085
546342005034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342005035	S-adenosylmethionine binding site [chemical binding]; other site
546342005036	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
546342005037	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342005038	S-adenosylmethionine binding site [chemical binding]; other site
546342005039	aminoglycoside resistance protein; Provisional; Region: PRK13746
546342005040	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
546342005041	active site
546342005042	NTP binding site [chemical binding]; other site
546342005043	metal binding triad [ion binding]; metal-binding site
546342005044	antibiotic binding site [chemical binding]; other site
546342005045	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
546342005046	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
546342005047	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
546342005048	Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195
546342005049	Int/Topo IB signature motif; other site
546342005050	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
546342005051	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
546342005052	Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194
546342005053	Int/Topo IB signature motif; other site
546342005054	hypothetical protein; Reviewed; Region: PRK00024
546342005055	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
546342005056	MPN+ (JAMM) motif; other site
546342005057	Zinc-binding site [ion binding]; other site
546342005058	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
546342005059	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
546342005060	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
546342005061	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
546342005062	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546342005063	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546342005064	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
546342005065	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
546342005066	active site
546342005067	HIGH motif; other site
546342005068	nucleotide binding site [chemical binding]; other site
546342005069	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
546342005070	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
546342005071	active site
546342005072	KMSKS motif; other site
546342005073	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
546342005074	tRNA binding surface [nucleotide binding]; other site
546342005075	anticodon binding site; other site
546342005076	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
546342005077	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
546342005078	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
546342005079	Putative ammonia monooxygenase; Region: AmoA; pfam05145
546342005080	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
546342005081	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
546342005082	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546342005083	inhibitor-cofactor binding pocket; inhibition site
546342005084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342005085	catalytic residue [active]
546342005086	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
546342005087	dimer interface [polypeptide binding]; other site
546342005088	active site
546342005089	Schiff base residues; other site
546342005090	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
546342005091	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
546342005092	active site
546342005093	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
546342005094	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
546342005095	domain interfaces; other site
546342005096	active site
546342005097	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
546342005098	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
546342005099	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
546342005100	tRNA; other site
546342005101	putative tRNA binding site [nucleotide binding]; other site
546342005102	putative NADP binding site [chemical binding]; other site
546342005103	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
546342005104	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
546342005105	G1 box; other site
546342005106	GTP/Mg2+ binding site [chemical binding]; other site
546342005107	Switch I region; other site
546342005108	G2 box; other site
546342005109	G3 box; other site
546342005110	Switch II region; other site
546342005111	G4 box; other site
546342005112	G5 box; other site
546342005113	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
546342005114	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
546342005115	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342005116	Walker A motif; other site
546342005117	ATP binding site [chemical binding]; other site
546342005118	Walker B motif; other site
546342005119	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
546342005120	trigger factor; Provisional; Region: tig; PRK01490
546342005121	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
546342005122	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
546342005123	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
546342005124	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
546342005125	23S rRNA binding site [nucleotide binding]; other site
546342005126	L21 binding site [polypeptide binding]; other site
546342005127	L13 binding site [polypeptide binding]; other site
546342005128	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
546342005129	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
546342005130	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
546342005131	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
546342005132	lysine transporter; Provisional; Region: PRK10836
546342005133	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
546342005134	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
546342005135	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
546342005136	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
546342005137	active site
546342005138	dimer interface [polypeptide binding]; other site
546342005139	motif 1; other site
546342005140	motif 2; other site
546342005141	motif 3; other site
546342005142	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
546342005143	anticodon binding site; other site
546342005144	primosomal protein DnaI; Reviewed; Region: PRK08939
546342005145	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
546342005146	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342005147	Walker A motif; other site
546342005148	ATP binding site [chemical binding]; other site
546342005149	Walker B motif; other site
546342005150	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
546342005151	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
546342005152	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
546342005153	ATP cone domain; Region: ATP-cone; pfam03477
546342005154	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
546342005155	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
546342005156	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
546342005157	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
546342005158	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
546342005159	CoA-binding site [chemical binding]; other site
546342005160	ATP-binding [chemical binding]; other site
546342005161	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
546342005162	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
546342005163	DNA binding site [nucleotide binding]
546342005164	catalytic residue [active]
546342005165	H2TH interface [polypeptide binding]; other site
546342005166	putative catalytic residues [active]
546342005167	turnover-facilitating residue; other site
546342005168	intercalation triad [nucleotide binding]; other site
546342005169	8OG recognition residue [nucleotide binding]; other site
546342005170	putative reading head residues; other site
546342005171	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
546342005172	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
546342005173	DNA polymerase I; Provisional; Region: PRK05755
546342005174	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
546342005175	active site
546342005176	metal binding site 1 [ion binding]; metal-binding site
546342005177	putative 5' ssDNA interaction site; other site
546342005178	metal binding site 3; metal-binding site
546342005179	metal binding site 2 [ion binding]; metal-binding site
546342005180	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
546342005181	putative DNA binding site [nucleotide binding]; other site
546342005182	putative metal binding site [ion binding]; other site
546342005183	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
546342005184	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
546342005185	active site
546342005186	DNA binding site [nucleotide binding]
546342005187	catalytic site [active]
546342005188	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
546342005189	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546342005190	dimer interface [polypeptide binding]; other site
546342005191	phosphorylation site [posttranslational modification]
546342005192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342005193	ATP binding site [chemical binding]; other site
546342005194	Mg2+ binding site [ion binding]; other site
546342005195	G-X-G motif; other site
546342005196	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546342005197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342005198	active site
546342005199	phosphorylation site [posttranslational modification]
546342005200	intermolecular recognition site; other site
546342005201	dimerization interface [polypeptide binding]; other site
546342005202	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546342005203	DNA binding site [nucleotide binding]
546342005204	isocitrate dehydrogenase; Reviewed; Region: PRK07006
546342005205	isocitrate dehydrogenase; Validated; Region: PRK07362
546342005206	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
546342005207	dimer interface [polypeptide binding]; other site
546342005208	Citrate synthase; Region: Citrate_synt; pfam00285
546342005209	active site
546342005210	citrylCoA binding site [chemical binding]; other site
546342005211	oxalacetate/citrate binding site [chemical binding]; other site
546342005212	coenzyme A binding site [chemical binding]; other site
546342005213	catalytic triad [active]
546342005214	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
546342005215	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
546342005216	pyruvate kinase; Provisional; Region: PRK06354
546342005217	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
546342005218	domain interfaces; other site
546342005219	active site
546342005220	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
546342005221	6-phosphofructokinase; Provisional; Region: PRK03202
546342005222	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
546342005223	active site
546342005224	ADP/pyrophosphate binding site [chemical binding]; other site
546342005225	dimerization interface [polypeptide binding]; other site
546342005226	allosteric effector site; other site
546342005227	fructose-1,6-bisphosphate binding site; other site
546342005228	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
546342005229	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
546342005230	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
546342005231	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
546342005232	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
546342005233	Malic enzyme, N-terminal domain; Region: malic; pfam00390
546342005234	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
546342005235	putative NAD(P) binding site [chemical binding]; other site
546342005236	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
546342005237	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
546342005238	active site
546342005239	PHP Thumb interface [polypeptide binding]; other site
546342005240	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
546342005241	generic binding surface I; other site
546342005242	generic binding surface II; other site
546342005243	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
546342005244	DHH family; Region: DHH; pfam01368
546342005245	DHHA1 domain; Region: DHHA1; pfam02272
546342005246	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
546342005247	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
546342005248	DNA-binding site [nucleotide binding]; DNA binding site
546342005249	DRTGG domain; Region: DRTGG; pfam07085
546342005250	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
546342005251	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
546342005252	active site 2 [active]
546342005253	active site 1 [active]
546342005254	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546342005255	Ligand Binding Site [chemical binding]; other site
546342005256	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
546342005257	metal-dependent hydrolase; Provisional; Region: PRK00685
546342005258	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
546342005259	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
546342005260	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
546342005261	active site
546342005262	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
546342005263	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
546342005264	hexamer interface [polypeptide binding]; other site
546342005265	ligand binding site [chemical binding]; other site
546342005266	putative active site [active]
546342005267	NAD(P) binding site [chemical binding]; other site
546342005268	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
546342005269	Ligand Binding Site [chemical binding]; other site
546342005270	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
546342005271	propionate/acetate kinase; Provisional; Region: PRK12379
546342005272	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
546342005273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342005274	S-adenosylmethionine binding site [chemical binding]; other site
546342005275	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
546342005276	dimer interface [polypeptide binding]; other site
546342005277	catalytic triad [active]
546342005278	peroxidatic and resolving cysteines [active]
546342005279	hypothetical protein; Provisional; Region: PRK10621
546342005280	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
546342005281	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
546342005282	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
546342005283	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
546342005284	Ligand Binding Site [chemical binding]; other site
546342005285	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
546342005286	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
546342005287	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546342005288	catalytic residue [active]
546342005289	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
546342005290	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
546342005291	GAF domain; Region: GAF_2; pfam13185
546342005292	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
546342005293	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
546342005294	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546342005295	RNA binding surface [nucleotide binding]; other site
546342005296	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
546342005297	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
546342005298	active site
546342005299	catalytic site [active]
546342005300	OsmC-like protein; Region: OsmC; cl00767
546342005301	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
546342005302	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546342005303	catalytic residue [active]
546342005304	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
546342005305	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
546342005306	ligand binding site [chemical binding]; other site
546342005307	NAD binding site [chemical binding]; other site
546342005308	dimerization interface [polypeptide binding]; other site
546342005309	catalytic site [active]
546342005310	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
546342005311	putative L-serine binding site [chemical binding]; other site
546342005312	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
546342005313	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342005314	motif II; other site
546342005315	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
546342005316	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
546342005317	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
546342005318	active site turn [active]
546342005319	phosphorylation site [posttranslational modification]
546342005320	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
546342005321	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
546342005322	putative acyl-acceptor binding pocket; other site
546342005323	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
546342005324	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
546342005325	protein binding site [polypeptide binding]; other site
546342005326	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
546342005327	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
546342005328	active site
546342005329	HIGH motif; other site
546342005330	dimer interface [polypeptide binding]; other site
546342005331	KMSKS motif; other site
546342005332	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546342005333	RNA binding surface [nucleotide binding]; other site
546342005334	haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
546342005335	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
546342005336	NEAr Transporter domain; Region: NEAT; smart00725
546342005337	NEAr Transporter domain; Region: NEAT; smart00725
546342005338	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
546342005339	heme-binding site [chemical binding]; other site
546342005340	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
546342005341	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
546342005342	Potassium binding sites [ion binding]; other site
546342005343	Cesium cation binding sites [ion binding]; other site
546342005344	acetyl-CoA synthetase; Provisional; Region: PRK04319
546342005345	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
546342005346	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
546342005347	active site
546342005348	acyl-activating enzyme (AAE) consensus motif; other site
546342005349	putative CoA binding site [chemical binding]; other site
546342005350	AMP binding site [chemical binding]; other site
546342005351	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
546342005352	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
546342005353	active site
546342005354	Zn binding site [ion binding]; other site
546342005355	catabolite control protein A; Region: ccpA; TIGR01481
546342005356	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546342005357	DNA binding site [nucleotide binding]
546342005358	domain linker motif; other site
546342005359	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
546342005360	dimerization interface [polypeptide binding]; other site
546342005361	effector binding site; other site
546342005362	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
546342005363	Chorismate mutase type II; Region: CM_2; cl00693
546342005364	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
546342005365	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342005366	MULE transposase domain; Region: MULE; pfam10551
546342005367	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
546342005368	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
546342005369	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
546342005370	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546342005371	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546342005372	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
546342005373	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
546342005374	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
546342005375	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
546342005376	putative tRNA-binding site [nucleotide binding]; other site
546342005377	hypothetical protein; Provisional; Region: PRK13668
546342005378	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
546342005379	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
546342005380	catalytic residues [active]
546342005381	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
546342005382	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
546342005383	oligomer interface [polypeptide binding]; other site
546342005384	active site
546342005385	metal binding site [ion binding]; metal-binding site
546342005386	Predicted small secreted protein [Function unknown]; Region: COG5584
546342005387	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
546342005388	Transposase IS200 like; Region: Y1_Tnp; pfam01797
546342005389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342005390	S-adenosylmethionine binding site [chemical binding]; other site
546342005391	Phosphotransferase enzyme family; Region: APH; pfam01636
546342005392	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
546342005393	active site
546342005394	substrate binding site [chemical binding]; other site
546342005395	ATP binding site [chemical binding]; other site
546342005396	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
546342005397	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
546342005398	homodimer interface [polypeptide binding]; other site
546342005399	substrate-cofactor binding pocket; other site
546342005400	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342005401	catalytic residue [active]
546342005402	dipeptidase PepV; Reviewed; Region: PRK07318
546342005403	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
546342005404	active site
546342005405	metal binding site [ion binding]; metal-binding site
546342005406	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
546342005407	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
546342005408	RNA binding surface [nucleotide binding]; other site
546342005409	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
546342005410	active site
546342005411	uracil binding [chemical binding]; other site
546342005412	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
546342005413	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
546342005414	HI0933-like protein; Region: HI0933_like; pfam03486
546342005415	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
546342005416	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
546342005417	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005418	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005419	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005420	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005421	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005422	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005423	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005424	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005425	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005426	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005427	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005428	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005429	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005430	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005431	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
546342005432	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
546342005433	active site residue [active]
546342005434	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
546342005435	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
546342005436	HIGH motif; other site
546342005437	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
546342005438	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
546342005439	active site
546342005440	KMSKS motif; other site
546342005441	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
546342005442	tRNA binding surface [nucleotide binding]; other site
546342005443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342005444	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342005445	putative substrate translocation pore; other site
546342005446	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
546342005447	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342005448	S-adenosylmethionine binding site [chemical binding]; other site
546342005449	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342005450	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
546342005451	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
546342005452	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
546342005453	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
546342005454	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
546342005455	homopentamer interface [polypeptide binding]; other site
546342005456	active site
546342005457	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
546342005458	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
546342005459	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
546342005460	dimerization interface [polypeptide binding]; other site
546342005461	active site
546342005462	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
546342005463	Lumazine binding domain; Region: Lum_binding; pfam00677
546342005464	Lumazine binding domain; Region: Lum_binding; pfam00677
546342005465	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
546342005466	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
546342005467	catalytic motif [active]
546342005468	Zn binding site [ion binding]; other site
546342005469	RibD C-terminal domain; Region: RibD_C; cl17279
546342005470	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
546342005471	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
546342005472	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
546342005473	arsenical pump membrane protein; Provisional; Region: PRK15445
546342005474	transmembrane helices; other site
546342005475	Low molecular weight phosphatase family; Region: LMWPc; cd00115
546342005476	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
546342005477	active site
546342005478	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
546342005479	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
546342005480	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342005481	MULE transposase domain; Region: MULE; pfam10551
546342005482	CAAX protease self-immunity; Region: Abi; pfam02517
546342005483	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
546342005484	active site
546342005485	intersubunit interactions; other site
546342005486	catalytic residue [active]
546342005487	camphor resistance protein CrcB; Provisional; Region: PRK14201
546342005488	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
546342005489	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342005490	MULE transposase domain; Region: MULE; pfam10551
546342005491	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
546342005492	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
546342005493	DNA binding residues [nucleotide binding]
546342005494	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342005495	MULE transposase domain; Region: MULE; pfam10551
546342005496	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
546342005497	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546342005498	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546342005499	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546342005500	active site
546342005501	catalytic tetrad [active]
546342005502	S-adenosylmethionine synthetase; Validated; Region: PRK05250
546342005503	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
546342005504	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
546342005505	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
546342005506	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
546342005507	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
546342005508	active site
546342005509	substrate-binding site [chemical binding]; other site
546342005510	metal-binding site [ion binding]
546342005511	ATP binding site [chemical binding]; other site
546342005512	Transposase IS200 like; Region: Y1_Tnp; pfam01797
546342005513	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
546342005514	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
546342005515	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
546342005516	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
546342005517	nudix motif; other site
546342005518	Haemolytic domain; Region: Haemolytic; pfam01809
546342005519	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
546342005520	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
546342005521	metal binding site [ion binding]; metal-binding site
546342005522	substrate binding pocket [chemical binding]; other site
546342005523	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
546342005524	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
546342005525	acyl-activating enzyme (AAE) consensus motif; other site
546342005526	putative AMP binding site [chemical binding]; other site
546342005527	putative active site [active]
546342005528	putative CoA binding site [chemical binding]; other site
546342005529	Excalibur calcium-binding domain; Region: Excalibur; smart00894
546342005530	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
546342005531	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
546342005532	Domain of unknown function (DUF955); Region: DUF955; pfam06114
546342005533	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
546342005534	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342005535	MULE transposase domain; Region: MULE; pfam10551
546342005536	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
546342005537	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
546342005538	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
546342005539	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
546342005540	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546342005541	ferrochelatase; Provisional; Region: PRK12435
546342005542	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
546342005543	C-terminal domain interface [polypeptide binding]; other site
546342005544	active site
546342005545	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
546342005546	active site
546342005547	N-terminal domain interface [polypeptide binding]; other site
546342005548	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
546342005549	substrate binding site [chemical binding]; other site
546342005550	active site
546342005551	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
546342005552	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
546342005553	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
546342005554	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
546342005555	Walker A/P-loop; other site
546342005556	ATP binding site [chemical binding]; other site
546342005557	Q-loop/lid; other site
546342005558	ABC transporter signature motif; other site
546342005559	Walker B; other site
546342005560	D-loop; other site
546342005561	H-loop/switch region; other site
546342005562	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
546342005563	HIT family signature motif; other site
546342005564	catalytic residue [active]
546342005565	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
546342005566	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
546342005567	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
546342005568	SurA N-terminal domain; Region: SurA_N_3; cl07813
546342005569	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
546342005570	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
546342005571	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
546342005572	generic binding surface II; other site
546342005573	generic binding surface I; other site
546342005574	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546342005575	Zn2+ binding site [ion binding]; other site
546342005576	Mg2+ binding site [ion binding]; other site
546342005577	Uncharacterized conserved protein [Function unknown]; Region: COG4717
546342005578	P-loop containing region of AAA domain; Region: AAA_29; cl17516
546342005579	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
546342005580	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
546342005581	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
546342005582	active site
546342005583	metal binding site [ion binding]; metal-binding site
546342005584	DNA binding site [nucleotide binding]
546342005585	hypothetical protein; Provisional; Region: PRK13676
546342005586	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
546342005587	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546342005588	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342005589	non-specific DNA binding site [nucleotide binding]; other site
546342005590	salt bridge; other site
546342005591	sequence-specific DNA binding site [nucleotide binding]; other site
546342005592	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546342005593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342005594	active site
546342005595	phosphorylation site [posttranslational modification]
546342005596	intermolecular recognition site; other site
546342005597	dimerization interface [polypeptide binding]; other site
546342005598	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546342005599	DNA binding residues [nucleotide binding]
546342005600	dimerization interface [polypeptide binding]; other site
546342005601	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546342005602	GAF domain; Region: GAF_3; pfam13492
546342005603	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
546342005604	Histidine kinase; Region: HisKA_3; pfam07730
546342005605	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342005606	ATP binding site [chemical binding]; other site
546342005607	Mg2+ binding site [ion binding]; other site
546342005608	G-X-G motif; other site
546342005609	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
546342005610	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
546342005611	active site
546342005612	fumarate hydratase; Reviewed; Region: fumC; PRK00485
546342005613	Class II fumarases; Region: Fumarase_classII; cd01362
546342005614	active site
546342005615	tetramer interface [polypeptide binding]; other site
546342005616	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
546342005617	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
546342005618	active site
546342005619	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
546342005620	epoxyqueuosine reductase; Region: TIGR00276
546342005621	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
546342005622	HEAT repeats; Region: HEAT_2; pfam13646
546342005623	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
546342005624	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
546342005625	Walker A/P-loop; other site
546342005626	ATP binding site [chemical binding]; other site
546342005627	Q-loop/lid; other site
546342005628	ABC transporter signature motif; other site
546342005629	Walker B; other site
546342005630	D-loop; other site
546342005631	H-loop/switch region; other site
546342005632	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546342005633	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
546342005634	substrate binding pocket [chemical binding]; other site
546342005635	membrane-bound complex binding site; other site
546342005636	hinge residues; other site
546342005637	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
546342005638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342005639	dimer interface [polypeptide binding]; other site
546342005640	conserved gate region; other site
546342005641	putative PBP binding loops; other site
546342005642	ABC-ATPase subunit interface; other site
546342005643	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
546342005644	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
546342005645	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
546342005646	Transposase; Region: DDE_Tnp_ISL3; pfam01610
546342005647	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
546342005648	metal binding site 2 [ion binding]; metal-binding site
546342005649	putative DNA binding helix; other site
546342005650	metal binding site 1 [ion binding]; metal-binding site
546342005651	dimer interface [polypeptide binding]; other site
546342005652	structural Zn2+ binding site [ion binding]; other site
546342005653	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
546342005654	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
546342005655	putative ligand binding site [chemical binding]; other site
546342005656	NAD binding site [chemical binding]; other site
546342005657	catalytic site [active]
546342005658	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
546342005659	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
546342005660	catalytic triad [active]
546342005661	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
546342005662	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546342005663	inhibitor-cofactor binding pocket; inhibition site
546342005664	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342005665	catalytic residue [active]
546342005666	Predicted membrane protein [Function unknown]; Region: COG4129
546342005667	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
546342005668	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546342005669	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546342005670	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
546342005671	Walker A/P-loop; other site
546342005672	ATP binding site [chemical binding]; other site
546342005673	Q-loop/lid; other site
546342005674	ABC transporter signature motif; other site
546342005675	Walker B; other site
546342005676	D-loop; other site
546342005677	H-loop/switch region; other site
546342005678	hypothetical protein; Provisional; Region: PRK13662
546342005679	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
546342005680	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
546342005681	minor groove reading motif; other site
546342005682	helix-hairpin-helix signature motif; other site
546342005683	substrate binding pocket [chemical binding]; other site
546342005684	active site
546342005685	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
546342005686	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
546342005687	DNA binding and oxoG recognition site [nucleotide binding]
546342005688	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
546342005689	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
546342005690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342005691	Walker A/P-loop; other site
546342005692	ATP binding site [chemical binding]; other site
546342005693	Q-loop/lid; other site
546342005694	ABC transporter signature motif; other site
546342005695	Walker B; other site
546342005696	H-loop/switch region; other site
546342005697	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
546342005698	RecX family; Region: RecX; cl00936
546342005699	glycosyltransferase; Provisional; Region: PRK13481
546342005700	Transglycosylase; Region: Transgly; pfam00912
546342005701	intracellular protease, PfpI family; Region: PfpI; TIGR01382
546342005702	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
546342005703	proposed catalytic triad [active]
546342005704	conserved cys residue [active]
546342005705	CHAP domain; Region: CHAP; pfam05257
546342005706	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
546342005707	amidase catalytic site [active]
546342005708	Zn binding residues [ion binding]; other site
546342005709	substrate binding site [chemical binding]; other site
546342005710	Bacterial SH3 domain; Region: SH3_5; pfam08460
546342005711	Bacteriophage holin; Region: Phage_holin_1; pfam04531
546342005712	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
546342005713	CHAP domain; Region: CHAP; pfam05257
546342005714	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
546342005715	Lysozyme subfamily 2; Region: LYZ2; smart00047
546342005716	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
546342005717	phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669
546342005718	Protein of unknown function (DUF2977); Region: DUF2977; pfam11192
546342005719	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
546342005720	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
546342005721	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
546342005722	active site
546342005723	catalytic triad [active]
546342005724	oxyanion hole [active]
546342005725	Phage tail protein; Region: Sipho_tail; pfam05709
546342005726	Phage-related protein [Function unknown]; Region: COG5412
546342005727	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
546342005728	Phage protein; Region: DUF3647; pfam12363
546342005729	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
546342005730	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
546342005731	Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055
546342005732	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
546342005733	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
546342005734	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
546342005735	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
546342005736	phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547
546342005737	Terminase-like family; Region: Terminase_6; pfam03237
546342005738	Terminase small subunit; Region: Terminase_2; cl01513
546342005739	Transcriptional activator RinB; Region: RinB; pfam06116
546342005740	Protein of unknown function (DUF1381); Region: DUF1381; pfam07129
546342005741	dUTPase; Region: dUTPase_2; pfam08761
546342005742	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
546342005743	active site
546342005744	homodimer interface [polypeptide binding]; other site
546342005745	metal binding site [ion binding]; metal-binding site
546342005746	Protein of unknown function (DUF1024); Region: DUF1024; pfam06260
546342005747	Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194
546342005748	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
546342005749	Protein of unknown function (DUF3113); Region: DUF3113; pfam11310
546342005750	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
546342005751	Protein of unknown function (DUF3269); Region: DUF3269; pfam11673
546342005752	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
546342005753	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
546342005754	Walker A motif; other site
546342005755	ATP binding site [chemical binding]; other site
546342005756	Walker B motif; other site
546342005757	DNA binding loops [nucleotide binding]
546342005758	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
546342005759	Protein of unknown function (DUF968); Region: DUF968; pfam06147
546342005760	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
546342005761	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
546342005762	dimer interface [polypeptide binding]; other site
546342005763	ssDNA binding site [nucleotide binding]; other site
546342005764	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546342005765	ERF superfamily; Region: ERF; pfam04404
546342005766	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352
546342005767	Protein of unknown function (DUF1108); Region: DUF1108; pfam06531
546342005768	Protein of unknown function (DUF1270); Region: DUF1270; pfam06900
546342005769	AntA/AntB antirepressor; Region: AntA; cl01430
546342005770	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
546342005771	BRO family, N-terminal domain; Region: Bro-N; smart01040
546342005772	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
546342005773	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342005774	non-specific DNA binding site [nucleotide binding]; other site
546342005775	salt bridge; other site
546342005776	sequence-specific DNA binding site [nucleotide binding]; other site
546342005777	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546342005778	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342005779	sequence-specific DNA binding site [nucleotide binding]; other site
546342005780	salt bridge; other site
546342005781	Domain of unknown function (DUF955); Region: DUF955; pfam06114
546342005782	Short C-terminal domain; Region: SHOCT; pfam09851
546342005783	PemK-like protein; Region: PemK; pfam02452
546342005784	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
546342005785	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
546342005786	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
546342005787	Int/Topo IB signature motif; other site
546342005788	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
546342005789	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546342005790	FeS/SAM binding site; other site
546342005791	YfkB-like domain; Region: YfkB; pfam08756
546342005792	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
546342005793	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
546342005794	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
546342005795	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
546342005796	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
546342005797	Low molecular weight phosphatase family; Region: LMWPc; cd00115
546342005798	active site
546342005799	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
546342005800	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546342005801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342005802	active site
546342005803	phosphorylation site [posttranslational modification]
546342005804	intermolecular recognition site; other site
546342005805	dimerization interface [polypeptide binding]; other site
546342005806	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546342005807	DNA binding residues [nucleotide binding]
546342005808	dimerization interface [polypeptide binding]; other site
546342005809	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
546342005810	Histidine kinase; Region: HisKA_3; pfam07730
546342005811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342005812	ATP binding site [chemical binding]; other site
546342005813	Mg2+ binding site [ion binding]; other site
546342005814	G-X-G motif; other site
546342005815	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
546342005816	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
546342005817	active site
546342005818	Predicted membrane protein [Function unknown]; Region: COG4129
546342005819	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
546342005820	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
546342005821	catalytic triad [active]
546342005822	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
546342005823	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546342005824	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
546342005825	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
546342005826	Ferritin-like domain; Region: Ferritin; pfam00210
546342005827	ferroxidase diiron center [ion binding]; other site
546342005828	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
546342005829	active site
546342005830	catalytic site [active]
546342005831	substrate binding site [chemical binding]; other site
546342005832	DNA polymerase IV; Validated; Region: PRK02406
546342005833	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
546342005834	active site
546342005835	DNA binding site [nucleotide binding]
546342005836	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
546342005837	TRAM domain; Region: TRAM; cl01282
546342005838	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
546342005839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342005840	S-adenosylmethionine binding site [chemical binding]; other site
546342005841	putative lipid kinase; Reviewed; Region: PRK13337
546342005842	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
546342005843	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
546342005844	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
546342005845	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
546342005846	GatB domain; Region: GatB_Yqey; pfam02637
546342005847	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
546342005848	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
546342005849	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
546342005850	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
546342005851	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
546342005852	Na binding site [ion binding]; other site
546342005853	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
546342005854	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
546342005855	putative dimer interface [polypeptide binding]; other site
546342005856	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
546342005857	putative dimer interface [polypeptide binding]; other site
546342005858	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
546342005859	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
546342005860	nucleotide binding pocket [chemical binding]; other site
546342005861	K-X-D-G motif; other site
546342005862	catalytic site [active]
546342005863	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
546342005864	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
546342005865	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
546342005866	Dimer interface [polypeptide binding]; other site
546342005867	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
546342005868	Part of AAA domain; Region: AAA_19; pfam13245
546342005869	Family description; Region: UvrD_C_2; pfam13538
546342005870	PcrB family; Region: PcrB; pfam01884
546342005871	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
546342005872	substrate binding site [chemical binding]; other site
546342005873	putative active site [active]
546342005874	dimer interface [polypeptide binding]; other site
546342005875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
546342005876	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
546342005877	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
546342005878	tetramer interface [polypeptide binding]; other site
546342005879	active site
546342005880	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
546342005881	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
546342005882	NETI protein; Region: NETI; pfam14044
546342005883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
546342005884	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
546342005885	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
546342005886	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
546342005887	homodimer interface [polypeptide binding]; other site
546342005888	NAD binding pocket [chemical binding]; other site
546342005889	ATP binding pocket [chemical binding]; other site
546342005890	Mg binding site [ion binding]; other site
546342005891	active-site loop [active]
546342005892	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
546342005893	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
546342005894	active site
546342005895	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
546342005896	active site
546342005897	dimer interface [polypeptide binding]; other site
546342005898	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
546342005899	Prephenate dehydratase; Region: PDT; pfam00800
546342005900	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
546342005901	putative L-Phe binding site [chemical binding]; other site
546342005902	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
546342005903	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
546342005904	transmembrane helices; other site
546342005905	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
546342005906	Isochorismatase family; Region: Isochorismatase; pfam00857
546342005907	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
546342005908	catalytic triad [active]
546342005909	conserved cis-peptide bond; other site
546342005910	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
546342005911	DHH family; Region: DHH; pfam01368
546342005912	DHHA2 domain; Region: DHHA2; pfam02833
546342005913	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
546342005914	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
546342005915	NAD(P) binding site [chemical binding]; other site
546342005916	catalytic residues [active]
546342005917	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
546342005918	YolD-like protein; Region: YolD; pfam08863
546342005919	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
546342005920	active site
546342005921	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
546342005922	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
546342005923	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
546342005924	Bacterial PH domain; Region: DUF304; cl01348
546342005925	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
546342005926	Integrase core domain; Region: rve; pfam00665
546342005927	Small integral membrane protein [Function unknown]; Region: COG5546
546342005928	CHAP domain; Region: CHAP; pfam05257
546342005929	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
546342005930	Bacterial SH3 domain; Region: SH3_5; pfam08460
546342005931	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
546342005932	MAP domain; Region: MAP; pfam03642
546342005933	MAP domain; Region: MAP; pfam03642
546342005934	MAP domain; Region: MAP; pfam03642
546342005935	MAP domain; Region: MAP; pfam03642
546342005936	MAP domain; Region: MAP; pfam03642
546342005937	MAP domain; Region: MAP; pfam03642
546342005938	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
546342005939	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546342005940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342005941	homodimer interface [polypeptide binding]; other site
546342005942	catalytic residue [active]
546342005943	Predicted transcriptional regulators [Transcription]; Region: COG1725
546342005944	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546342005945	DNA-binding site [nucleotide binding]; DNA binding site
546342005946	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
546342005947	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
546342005948	Walker A/P-loop; other site
546342005949	ATP binding site [chemical binding]; other site
546342005950	Q-loop/lid; other site
546342005951	ABC transporter signature motif; other site
546342005952	Walker B; other site
546342005953	D-loop; other site
546342005954	H-loop/switch region; other site
546342005955	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
546342005956	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
546342005957	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
546342005958	Walker A/P-loop; other site
546342005959	ATP binding site [chemical binding]; other site
546342005960	Q-loop/lid; other site
546342005961	ABC transporter signature motif; other site
546342005962	Walker B; other site
546342005963	D-loop; other site
546342005964	H-loop/switch region; other site
546342005965	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
546342005966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
546342005967	Integrase core domain; Region: rve; pfam00665
546342005968	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
546342005969	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
546342005970	folate binding site [chemical binding]; other site
546342005971	NADP+ binding site [chemical binding]; other site
546342005972	thymidylate synthase; Region: thym_sym; TIGR03284
546342005973	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
546342005974	dimerization interface [polypeptide binding]; other site
546342005975	active site
546342005976	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
546342005977	Integrase core domain; Region: rve; pfam00665
546342005978	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
546342005979	GPI transamidase subunit PIG-U; Region: PIG-U; pfam06728
546342005980	HTH domain; Region: HTH_11; cl17392
546342005981	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
546342005982	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546342005983	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342005984	non-specific DNA binding site [nucleotide binding]; other site
546342005985	salt bridge; other site
546342005986	sequence-specific DNA binding site [nucleotide binding]; other site
546342005987	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
546342005988	polar chromosome segregation protein; Reviewed; Region: racA; PRK13182
546342005989	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342005990	MULE transposase domain; Region: MULE; pfam10551
546342005991	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
546342005992	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342005993	Coenzyme A binding pocket [chemical binding]; other site
546342005994	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
546342005995	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
546342005996	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
546342005997	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
546342005998	Phosphotransferase enzyme family; Region: APH; pfam01636
546342005999	active site
546342006000	ATP binding site [chemical binding]; other site
546342006001	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
546342006002	substrate binding site [chemical binding]; other site
546342006003	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342006004	MULE transposase domain; Region: MULE; pfam10551
546342006005	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342006006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342006007	putative substrate translocation pore; other site
546342006008	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546342006009	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546342006010	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
546342006011	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342006012	non-specific DNA binding site [nucleotide binding]; other site
546342006013	salt bridge; other site
546342006014	sequence-specific DNA binding site [nucleotide binding]; other site
546342006015	multiple promoter invertase; Provisional; Region: mpi; PRK13413
546342006016	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
546342006017	catalytic residues [active]
546342006018	catalytic nucleophile [active]
546342006019	Presynaptic Site I dimer interface [polypeptide binding]; other site
546342006020	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
546342006021	Synaptic Flat tetramer interface [polypeptide binding]; other site
546342006022	Synaptic Site I dimer interface [polypeptide binding]; other site
546342006023	DNA binding site [nucleotide binding]
546342006024	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
546342006025	DNA-binding interface [nucleotide binding]; DNA binding site
546342006026	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
546342006027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
546342006028	Integrase core domain; Region: rve; pfam00665
546342006029	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
546342006030	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
546342006031	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
546342006032	Ligand-gated ion channel; Region: Lig_chan; pfam00060
546342006033	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
546342006034	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
546342006035	TolA protein; Region: tolA_full; TIGR02794
546342006036	Phage tail protein; Region: Sipho_tail; cl17486
546342006037	Phage tail protein; Region: Sipho_tail; cl17486
546342006038	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
546342006039	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
546342006040	Translocation protein Sec62; Region: Sec62; cl02170
546342006041	Phage capsid family; Region: Phage_capsid; pfam05065
546342006042	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
546342006043	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
546342006044	oligomer interface [polypeptide binding]; other site
546342006045	active site residues [active]
546342006046	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
546342006047	Phage-related protein [Function unknown]; Region: COG4695; cl01923
546342006048	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
546342006049	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
546342006050	HNH endonuclease; Region: HNH; pfam01844
546342006051	active site
546342006052	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
546342006053	Protein of unknown function (DUF1514); Region: DUF1514; pfam07438
546342006054	Transcriptional activator RinB; Region: RinB; pfam06116
546342006055	Protein of unknown function (DUF1381); Region: DUF1381; pfam07129
546342006056	dUTPase; Region: dUTPase_2; pfam08761
546342006057	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
546342006058	active site
546342006059	homodimer interface [polypeptide binding]; other site
546342006060	metal binding site [ion binding]; metal-binding site
546342006061	YopX protein; Region: YopX; pfam09643
546342006062	Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194
546342006063	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
546342006064	Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570
546342006065	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
546342006066	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
546342006067	dimer interface [polypeptide binding]; other site
546342006068	ssDNA binding site [nucleotide binding]; other site
546342006069	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546342006070	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
546342006071	RecT family; Region: RecT; pfam03837
546342006072	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
546342006073	Protein of unknown function (DUF1108); Region: DUF1108; pfam06531
546342006074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707
546342006075	Phage anti-repressor protein [Transcription]; Region: COG3561
546342006076	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
546342006077	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342006078	salt bridge; other site
546342006079	non-specific DNA binding site [nucleotide binding]; other site
546342006080	sequence-specific DNA binding site [nucleotide binding]; other site
546342006081	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546342006082	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342006083	non-specific DNA binding site [nucleotide binding]; other site
546342006084	salt bridge; other site
546342006085	sequence-specific DNA binding site [nucleotide binding]; other site
546342006086	Predicted transcriptional regulator [Transcription]; Region: COG2932
546342006087	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
546342006088	Catalytic site [active]
546342006089	PemK-like protein; Region: PemK; pfam02452
546342006090	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
546342006091	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
546342006092	Int/Topo IB signature motif; other site
546342006093	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
546342006094	putative catalytic site [active]
546342006095	phosphate binding site [ion binding]; other site
546342006096	metal binding site A [ion binding]; metal-binding site
546342006097	metal binding site C [ion binding]; metal-binding site
546342006098	metal binding site B [ion binding]; metal-binding site
546342006099	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
546342006100	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
546342006101	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
546342006102	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
546342006103	metal binding site [ion binding]; metal-binding site
546342006104	dimer interface [polypeptide binding]; other site
546342006105	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
546342006106	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
546342006107	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
546342006108	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
546342006109	putative ligand binding residues [chemical binding]; other site
546342006110	Cation transport protein; Region: TrkH; cl17365
546342006111	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
546342006112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342006113	Coenzyme A binding pocket [chemical binding]; other site
546342006114	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
546342006115	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
546342006116	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
546342006117	ring oligomerisation interface [polypeptide binding]; other site
546342006118	ATP/Mg binding site [chemical binding]; other site
546342006119	stacking interactions; other site
546342006120	hinge regions; other site
546342006121	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
546342006122	oligomerisation interface [polypeptide binding]; other site
546342006123	mobile loop; other site
546342006124	roof hairpin; other site
546342006125	CAAX protease self-immunity; Region: Abi; pfam02517
546342006126	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
546342006127	dimer interface [polypeptide binding]; other site
546342006128	FMN binding site [chemical binding]; other site
546342006129	Predicted amidohydrolase [General function prediction only]; Region: COG0388
546342006130	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
546342006131	putative active site [active]
546342006132	catalytic triad [active]
546342006133	putative dimer interface [polypeptide binding]; other site
546342006134	delta-hemolysin; Provisional; Region: PRK14752
546342006135	Accessory gene regulator B; Region: AgrB; smart00793
546342006136	Staphylococcal AgrD protein; Region: AgrD; smart00794
546342006137	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342006138	Mg2+ binding site [ion binding]; other site
546342006139	G-X-G motif; other site
546342006140	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
546342006141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342006142	active site
546342006143	phosphorylation site [posttranslational modification]
546342006144	intermolecular recognition site; other site
546342006145	dimerization interface [polypeptide binding]; other site
546342006146	LytTr DNA-binding domain; Region: LytTR; pfam04397
546342006147	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
546342006148	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
546342006149	putative substrate binding site [chemical binding]; other site
546342006150	putative ATP binding site [chemical binding]; other site
546342006151	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
546342006152	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
546342006153	substrate binding [chemical binding]; other site
546342006154	active site
546342006155	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
546342006156	Transcriptional regulators [Transcription]; Region: PurR; COG1609
546342006157	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
546342006158	DNA binding site [nucleotide binding]
546342006159	domain linker motif; other site
546342006160	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
546342006161	dimerization interface [polypeptide binding]; other site
546342006162	ligand binding site [chemical binding]; other site
546342006163	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
546342006164	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
546342006165	CPxP  motif; other site
546342006166	Predicted transporter component [General function prediction only]; Region: COG2391
546342006167	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
546342006168	Sulphur transport; Region: Sulf_transp; pfam04143
546342006169	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
546342006170	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
546342006171	CoA binding domain; Region: CoA_binding; pfam02629
546342006172	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
546342006173	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546342006174	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546342006175	ABC transporter; Region: ABC_tran_2; pfam12848
546342006176	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
546342006177	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
546342006178	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
546342006179	Walker A/P-loop; other site
546342006180	ATP binding site [chemical binding]; other site
546342006181	Q-loop/lid; other site
546342006182	ABC transporter signature motif; other site
546342006183	Walker B; other site
546342006184	D-loop; other site
546342006185	H-loop/switch region; other site
546342006186	UGMP family protein; Validated; Region: PRK09604
546342006187	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
546342006188	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
546342006189	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342006190	Coenzyme A binding pocket [chemical binding]; other site
546342006191	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
546342006192	Glycoprotease family; Region: Peptidase_M22; pfam00814
546342006193	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
546342006194	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
546342006195	6-phosphogluconate dehydratase; Region: edd; TIGR01196
546342006196	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
546342006197	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
546342006198	PYR/PP interface [polypeptide binding]; other site
546342006199	dimer interface [polypeptide binding]; other site
546342006200	TPP binding site [chemical binding]; other site
546342006201	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
546342006202	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
546342006203	TPP-binding site [chemical binding]; other site
546342006204	dimer interface [polypeptide binding]; other site
546342006205	acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562
546342006206	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
546342006207	ketol-acid reductoisomerase; Provisional; Region: PRK05479
546342006208	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
546342006209	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
546342006210	2-isopropylmalate synthase; Validated; Region: PRK00915
546342006211	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
546342006212	active site
546342006213	catalytic residues [active]
546342006214	metal binding site [ion binding]; metal-binding site
546342006215	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
546342006216	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
546342006217	tartrate dehydrogenase; Region: TTC; TIGR02089
546342006218	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
546342006219	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
546342006220	substrate binding site [chemical binding]; other site
546342006221	ligand binding site [chemical binding]; other site
546342006222	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
546342006223	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
546342006224	substrate binding site [chemical binding]; other site
546342006225	threonine dehydratase; Validated; Region: PRK08639
546342006226	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
546342006227	tetramer interface [polypeptide binding]; other site
546342006228	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342006229	catalytic residue [active]
546342006230	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
546342006231	putative Ile/Val binding site [chemical binding]; other site
546342006232	hypothetical protein; Provisional; Region: PRK04351
546342006233	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
546342006234	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
546342006235	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
546342006236	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
546342006237	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
546342006238	RNA binding site [nucleotide binding]; other site
546342006239	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
546342006240	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
546342006241	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
546342006242	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
546342006243	DNA binding residues [nucleotide binding]
546342006244	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
546342006245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342006246	ATP binding site [chemical binding]; other site
546342006247	Mg2+ binding site [ion binding]; other site
546342006248	G-X-G motif; other site
546342006249	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
546342006250	anti sigma factor interaction site; other site
546342006251	regulatory phosphorylation site [posttranslational modification]; other site
546342006252	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
546342006253	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
546342006254	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
546342006255	PemK-like protein; Region: PemK; pfam02452
546342006256	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
546342006257	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
546342006258	active site
546342006259	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546342006260	dimer interface [polypeptide binding]; other site
546342006261	substrate binding site [chemical binding]; other site
546342006262	catalytic residues [active]
546342006263	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
546342006264	Uncharacterized conserved protein [Function unknown]; Region: COG3402
546342006265	Predicted membrane protein [Function unknown]; Region: COG3428
546342006266	Bacterial PH domain; Region: DUF304; pfam03703
546342006267	Bacterial PH domain; Region: DUF304; pfam03703
546342006268	Bacterial PH domain; Region: DUF304; cl01348
546342006269	potassium-transporting ATPase subunit C; Provisional; Region: PRK13998
546342006270	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
546342006271	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
546342006272	Soluble P-type ATPase [General function prediction only]; Region: COG4087
546342006273	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
546342006274	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
546342006275	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
546342006276	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
546342006277	Ligand Binding Site [chemical binding]; other site
546342006278	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546342006279	dimer interface [polypeptide binding]; other site
546342006280	phosphorylation site [posttranslational modification]
546342006281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342006282	ATP binding site [chemical binding]; other site
546342006283	Mg2+ binding site [ion binding]; other site
546342006284	G-X-G motif; other site
546342006285	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546342006286	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342006287	active site
546342006288	phosphorylation site [posttranslational modification]
546342006289	intermolecular recognition site; other site
546342006290	dimerization interface [polypeptide binding]; other site
546342006291	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546342006292	DNA binding site [nucleotide binding]
546342006293	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
546342006294	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
546342006295	ATP binding site [chemical binding]; other site
546342006296	Mg++ binding site [ion binding]; other site
546342006297	motif III; other site
546342006298	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546342006299	nucleotide binding region [chemical binding]; other site
546342006300	ATP-binding site [chemical binding]; other site
546342006301	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
546342006302	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
546342006303	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
546342006304	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
546342006305	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
546342006306	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
546342006307	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
546342006308	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
546342006309	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
546342006310	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
546342006311	putative homodimer interface [polypeptide binding]; other site
546342006312	putative homotetramer interface [polypeptide binding]; other site
546342006313	allosteric switch controlling residues; other site
546342006314	putative metal binding site [ion binding]; other site
546342006315	putative homodimer-homodimer interface [polypeptide binding]; other site
546342006316	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
546342006317	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
546342006318	putative active site [active]
546342006319	catalytic site [active]
546342006320	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
546342006321	putative active site [active]
546342006322	catalytic site [active]
546342006323	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
546342006324	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
546342006325	Zn2+ binding site [ion binding]; other site
546342006326	Mg2+ binding site [ion binding]; other site
546342006327	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
546342006328	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
546342006329	thiamine phosphate binding site [chemical binding]; other site
546342006330	active site
546342006331	pyrophosphate binding site [ion binding]; other site
546342006332	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
546342006333	substrate binding site [chemical binding]; other site
546342006334	multimerization interface [polypeptide binding]; other site
546342006335	ATP binding site [chemical binding]; other site
546342006336	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
546342006337	dimer interface [polypeptide binding]; other site
546342006338	substrate binding site [chemical binding]; other site
546342006339	ATP binding site [chemical binding]; other site
546342006340	thiaminase II; Region: salvage_TenA; TIGR04306
546342006341	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
546342006342	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
546342006343	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
546342006344	dimer interface [polypeptide binding]; other site
546342006345	ssDNA binding site [nucleotide binding]; other site
546342006346	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546342006347	YwpF-like protein; Region: YwpF; pfam14183
546342006348	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
546342006349	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
546342006350	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
546342006351	hinge; other site
546342006352	active site
546342006353	Predicted membrane protein [Function unknown]; Region: COG4836
546342006354	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
546342006355	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
546342006356	gamma subunit interface [polypeptide binding]; other site
546342006357	epsilon subunit interface [polypeptide binding]; other site
546342006358	LBP interface [polypeptide binding]; other site
546342006359	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
546342006360	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
546342006361	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
546342006362	alpha subunit interaction interface [polypeptide binding]; other site
546342006363	Walker A motif; other site
546342006364	ATP binding site [chemical binding]; other site
546342006365	Walker B motif; other site
546342006366	inhibitor binding site; inhibition site
546342006367	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
546342006368	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
546342006369	core domain interface [polypeptide binding]; other site
546342006370	delta subunit interface [polypeptide binding]; other site
546342006371	epsilon subunit interface [polypeptide binding]; other site
546342006372	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
546342006373	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
546342006374	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
546342006375	beta subunit interaction interface [polypeptide binding]; other site
546342006376	Walker A motif; other site
546342006377	ATP binding site [chemical binding]; other site
546342006378	Walker B motif; other site
546342006379	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
546342006380	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
546342006381	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
546342006382	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
546342006383	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
546342006384	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
546342006385	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
546342006386	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
546342006387	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
546342006388	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
546342006389	active site
546342006390	homodimer interface [polypeptide binding]; other site
546342006391	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
546342006392	active site
546342006393	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
546342006394	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
546342006395	dimer interface [polypeptide binding]; other site
546342006396	active site
546342006397	glycine-pyridoxal phosphate binding site [chemical binding]; other site
546342006398	folate binding site [chemical binding]; other site
546342006399	hypothetical protein; Provisional; Region: PRK13690
546342006400	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
546342006401	Low molecular weight phosphatase family; Region: LMWPc; cd00115
546342006402	active site
546342006403	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
546342006404	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
546342006405	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
546342006406	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342006407	S-adenosylmethionine binding site [chemical binding]; other site
546342006408	peptide chain release factor 1; Validated; Region: prfA; PRK00591
546342006409	This domain is found in peptide chain release factors; Region: PCRF; smart00937
546342006410	RF-1 domain; Region: RF-1; pfam00472
546342006411	thymidine kinase; Provisional; Region: PRK04296
546342006412	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
546342006413	transcription termination factor Rho; Provisional; Region: rho; PRK09376
546342006414	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
546342006415	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
546342006416	RNA binding site [nucleotide binding]; other site
546342006417	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
546342006418	multimer interface [polypeptide binding]; other site
546342006419	Walker A motif; other site
546342006420	ATP binding site [chemical binding]; other site
546342006421	Walker B motif; other site
546342006422	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
546342006423	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
546342006424	NAD binding site [chemical binding]; other site
546342006425	catalytic residues [active]
546342006426	Predicted transcriptional regulators [Transcription]; Region: COG1733
546342006427	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
546342006428	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
546342006429	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
546342006430	hinge; other site
546342006431	active site
546342006432	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
546342006433	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
546342006434	intersubunit interface [polypeptide binding]; other site
546342006435	active site
546342006436	zinc binding site [ion binding]; other site
546342006437	Na+ binding site [ion binding]; other site
546342006438	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
546342006439	CTP synthetase; Validated; Region: pyrG; PRK05380
546342006440	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
546342006441	Catalytic site [active]
546342006442	active site
546342006443	UTP binding site [chemical binding]; other site
546342006444	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
546342006445	active site
546342006446	putative oxyanion hole; other site
546342006447	catalytic triad [active]
546342006448	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
546342006449	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
546342006450	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342006451	Coenzyme A binding pocket [chemical binding]; other site
546342006452	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546342006453	Coenzyme A binding pocket [chemical binding]; other site
546342006454	pantothenate kinase; Provisional; Region: PRK13317
546342006455	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
546342006456	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
546342006457	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
546342006458	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
546342006459	metal binding site [ion binding]; metal-binding site
546342006460	S-ribosylhomocysteinase; Provisional; Region: PRK02260
546342006461	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
546342006462	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
546342006463	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
546342006464	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
546342006465	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
546342006466	intersubunit interface [polypeptide binding]; other site
546342006467	active site
546342006468	catalytic residue [active]
546342006469	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
546342006470	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
546342006471	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
546342006472	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
546342006473	dimerization interface [polypeptide binding]; other site
546342006474	DPS ferroxidase diiron center [ion binding]; other site
546342006475	ion pore; other site
546342006476	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
546342006477	EVE domain; Region: EVE; cl00728
546342006478	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
546342006479	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
546342006480	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
546342006481	NADH(P)-binding; Region: NAD_binding_10; pfam13460
546342006482	NAD(P) binding site [chemical binding]; other site
546342006483	putative active site [active]
546342006484	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546342006485	dimerization interface [polypeptide binding]; other site
546342006486	putative DNA binding site [nucleotide binding]; other site
546342006487	putative Zn2+ binding site [ion binding]; other site
546342006488	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
546342006489	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
546342006490	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
546342006491	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
546342006492	catalytic residues [active]
546342006493	SAP domain; Region: SAP; pfam02037
546342006494	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
546342006495	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342006496	active site
546342006497	motif I; other site
546342006498	motif II; other site
546342006499	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342006500	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
546342006501	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342006502	Walker A/P-loop; other site
546342006503	ATP binding site [chemical binding]; other site
546342006504	Q-loop/lid; other site
546342006505	ABC transporter signature motif; other site
546342006506	Walker B; other site
546342006507	D-loop; other site
546342006508	H-loop/switch region; other site
546342006509	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
546342006510	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
546342006511	glutaminase active site [active]
546342006512	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
546342006513	dimer interface [polypeptide binding]; other site
546342006514	active site
546342006515	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
546342006516	dimer interface [polypeptide binding]; other site
546342006517	active site
546342006518	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
546342006519	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
546342006520	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
546342006521	active site
546342006522	P-loop; other site
546342006523	phosphorylation site [posttranslational modification]
546342006524	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
546342006525	HTH domain; Region: HTH_11; pfam08279
546342006526	Mga helix-turn-helix domain; Region: Mga; pfam05043
546342006527	PRD domain; Region: PRD; pfam00874
546342006528	PRD domain; Region: PRD; pfam00874
546342006529	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
546342006530	active site
546342006531	P-loop; other site
546342006532	phosphorylation site [posttranslational modification]
546342006533	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
546342006534	active site
546342006535	phosphorylation site [posttranslational modification]
546342006536	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
546342006537	active site
546342006538	phosphorylation site [posttranslational modification]
546342006539	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
546342006540	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
546342006541	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
546342006542	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
546342006543	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
546342006544	active site
546342006545	substrate binding site [chemical binding]; other site
546342006546	metal binding site [ion binding]; metal-binding site
546342006547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
546342006548	YbbR-like protein; Region: YbbR; pfam07949
546342006549	TIGR00159 family protein; Region: TIGR00159
546342006550	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
546342006551	Arginase family; Region: Arginase; cd09989
546342006552	active site
546342006553	Mn binding site [ion binding]; other site
546342006554	oligomer interface [polypeptide binding]; other site
546342006555	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
546342006556	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
546342006557	Walker A motif; other site
546342006558	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342006559	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342006560	putative substrate translocation pore; other site
546342006561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342006562	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342006563	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342006564	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
546342006565	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
546342006566	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
546342006567	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
546342006568	substrate binding site; other site
546342006569	dimerization interface; other site
546342006570	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
546342006571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
546342006572	Nucleoside recognition; Region: Gate; pfam07670
546342006573	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546342006574	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342006575	ABC-ATPase subunit  interface; other site
546342006576	dimer interface [polypeptide binding]; other site
546342006577	putative PBP binding regions; other site
546342006578	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
546342006579	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
546342006580	ABC-ATPase subunit  interface; other site
546342006581	dimer interface [polypeptide binding]; other site
546342006582	putative PBP binding regions; other site
546342006583	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
546342006584	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
546342006585	siderophore binding site; other site
546342006586	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
546342006587	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
546342006588	dimer interface [polypeptide binding]; other site
546342006589	active site
546342006590	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
546342006591	substrate binding site [chemical binding]; other site
546342006592	catalytic residue [active]
546342006593	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
546342006594	IucA / IucC family; Region: IucA_IucC; pfam04183
546342006595	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
546342006596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342006597	putative substrate translocation pore; other site
546342006598	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
546342006599	IucA / IucC family; Region: IucA_IucC; pfam04183
546342006600	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
546342006601	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
546342006602	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546342006603	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
546342006604	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
546342006605	Asp23 family; Region: Asp23; pfam03780
546342006606	Small integral membrane protein [Function unknown]; Region: COG5547
546342006607	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
546342006608	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
546342006609	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
546342006610	putative NAD(P) binding site [chemical binding]; other site
546342006611	dimer interface [polypeptide binding]; other site
546342006612	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
546342006613	Prostaglandin dehydrogenases; Region: PGDH; cd05288
546342006614	NAD(P) binding site [chemical binding]; other site
546342006615	substrate binding site [chemical binding]; other site
546342006616	dimer interface [polypeptide binding]; other site
546342006617	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
546342006618	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
546342006619	beta-galactosidase; Region: BGL; TIGR03356
546342006620	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
546342006621	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
546342006622	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
546342006623	active site
546342006624	P-loop; other site
546342006625	phosphorylation site [posttranslational modification]
546342006626	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
546342006627	methionine cluster; other site
546342006628	active site
546342006629	phosphorylation site [posttranslational modification]
546342006630	metal binding site [ion binding]; metal-binding site
546342006631	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
546342006632	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
546342006633	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
546342006634	putative substrate binding site [chemical binding]; other site
546342006635	putative ATP binding site [chemical binding]; other site
546342006636	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
546342006637	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
546342006638	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
546342006639	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
546342006640	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
546342006641	NAD-dependent deacetylase; Provisional; Region: PRK00481
546342006642	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
546342006643	NAD+ binding site [chemical binding]; other site
546342006644	substrate binding site [chemical binding]; other site
546342006645	putative Zn binding site [ion binding]; other site
546342006646	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
546342006647	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
546342006648	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
546342006649	active site
546342006650	catalytic tetrad [active]
546342006651	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
546342006652	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
546342006653	DNA binding residues [nucleotide binding]
546342006654	putative dimer interface [polypeptide binding]; other site
546342006655	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
546342006656	substrate binding site [chemical binding]; other site
546342006657	catalytic residues [active]
546342006658	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
546342006659	Peptidase family M23; Region: Peptidase_M23; pfam01551
546342006660	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
546342006661	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
546342006662	active site
546342006663	motif I; other site
546342006664	motif II; other site
546342006665	MAP domain; Region: MAP; pfam03642
546342006666	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
546342006667	acetolactate synthase; Reviewed; Region: PRK08617
546342006668	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
546342006669	PYR/PP interface [polypeptide binding]; other site
546342006670	dimer interface [polypeptide binding]; other site
546342006671	TPP binding site [chemical binding]; other site
546342006672	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
546342006673	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
546342006674	TPP-binding site [chemical binding]; other site
546342006675	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
546342006676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342006677	Walker A motif; other site
546342006678	ATP binding site [chemical binding]; other site
546342006679	Walker B motif; other site
546342006680	arginine finger; other site
546342006681	Predicted helicase [General function prediction only]; Region: COG4889
546342006682	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
546342006683	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
546342006684	23S rRNA interface [nucleotide binding]; other site
546342006685	L3 interface [polypeptide binding]; other site
546342006686	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
546342006687	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
546342006688	dimerization interface 3.5A [polypeptide binding]; other site
546342006689	active site
546342006690	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
546342006691	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646
546342006692	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
546342006693	Walker A/P-loop; other site
546342006694	ATP binding site [chemical binding]; other site
546342006695	Q-loop/lid; other site
546342006696	ABC transporter signature motif; other site
546342006697	Walker B; other site
546342006698	D-loop; other site
546342006699	H-loop/switch region; other site
546342006700	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
546342006701	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
546342006702	Walker A/P-loop; other site
546342006703	ATP binding site [chemical binding]; other site
546342006704	Q-loop/lid; other site
546342006705	ABC transporter signature motif; other site
546342006706	Walker B; other site
546342006707	D-loop; other site
546342006708	H-loop/switch region; other site
546342006709	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
546342006710	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
546342006711	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
546342006712	alphaNTD homodimer interface [polypeptide binding]; other site
546342006713	alphaNTD - beta interaction site [polypeptide binding]; other site
546342006714	alphaNTD - beta' interaction site [polypeptide binding]; other site
546342006715	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
546342006716	30S ribosomal protein S11; Validated; Region: PRK05309
546342006717	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
546342006718	30S ribosomal protein S13; Region: bact_S13; TIGR03631
546342006719	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
546342006720	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
546342006721	rRNA binding site [nucleotide binding]; other site
546342006722	predicted 30S ribosome binding site; other site
546342006723	adenylate kinase; Reviewed; Region: adk; PRK00279
546342006724	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
546342006725	AMP-binding site [chemical binding]; other site
546342006726	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
546342006727	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
546342006728	SecY translocase; Region: SecY; pfam00344
546342006729	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
546342006730	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
546342006731	23S rRNA binding site [nucleotide binding]; other site
546342006732	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
546342006733	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
546342006734	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
546342006735	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
546342006736	5S rRNA interface [nucleotide binding]; other site
546342006737	L27 interface [polypeptide binding]; other site
546342006738	23S rRNA interface [nucleotide binding]; other site
546342006739	L5 interface [polypeptide binding]; other site
546342006740	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
546342006741	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
546342006742	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
546342006743	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
546342006744	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
546342006745	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
546342006746	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
546342006747	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
546342006748	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
546342006749	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
546342006750	RNA binding site [nucleotide binding]; other site
546342006751	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
546342006752	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
546342006753	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
546342006754	23S rRNA interface [nucleotide binding]; other site
546342006755	putative translocon interaction site; other site
546342006756	signal recognition particle (SRP54) interaction site; other site
546342006757	L23 interface [polypeptide binding]; other site
546342006758	trigger factor interaction site; other site
546342006759	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
546342006760	23S rRNA interface [nucleotide binding]; other site
546342006761	5S rRNA interface [nucleotide binding]; other site
546342006762	putative antibiotic binding site [chemical binding]; other site
546342006763	L25 interface [polypeptide binding]; other site
546342006764	L27 interface [polypeptide binding]; other site
546342006765	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
546342006766	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
546342006767	G-X-X-G motif; other site
546342006768	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
546342006769	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
546342006770	putative translocon binding site; other site
546342006771	protein-rRNA interface [nucleotide binding]; other site
546342006772	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
546342006773	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
546342006774	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
546342006775	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
546342006776	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
546342006777	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
546342006778	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
546342006779	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
546342006780	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
546342006781	DNA topoisomerase III; Provisional; Region: PRK07726
546342006782	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
546342006783	active site
546342006784	putative interdomain interaction site [polypeptide binding]; other site
546342006785	putative metal-binding site [ion binding]; other site
546342006786	putative nucleotide binding site [chemical binding]; other site
546342006787	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
546342006788	domain I; other site
546342006789	DNA binding groove [nucleotide binding]
546342006790	phosphate binding site [ion binding]; other site
546342006791	domain II; other site
546342006792	domain III; other site
546342006793	nucleotide binding site [chemical binding]; other site
546342006794	catalytic site [active]
546342006795	domain IV; other site
546342006796	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
546342006797	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342006798	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
546342006799	Coenzyme A binding pocket [chemical binding]; other site
546342006800	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
546342006801	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
546342006802	Predicted permeases [General function prediction only]; Region: COG0679
546342006803	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
546342006804	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
546342006805	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
546342006806	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
546342006807	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
546342006808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342006809	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342006810	putative substrate translocation pore; other site
546342006811	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342006812	Transcriptional regulators [Transcription]; Region: MarR; COG1846
546342006813	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
546342006814	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546342006815	FeS/SAM binding site; other site
546342006816	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
546342006817	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
546342006818	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
546342006819	GTP binding site; other site
546342006820	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
546342006821	MoaE interaction surface [polypeptide binding]; other site
546342006822	MoeB interaction surface [polypeptide binding]; other site
546342006823	thiocarboxylated glycine; other site
546342006824	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
546342006825	MoaE homodimer interface [polypeptide binding]; other site
546342006826	MoaD interaction [polypeptide binding]; other site
546342006827	active site residues [active]
546342006828	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
546342006829	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
546342006830	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
546342006831	dimer interface [polypeptide binding]; other site
546342006832	putative functional site; other site
546342006833	putative MPT binding site; other site
546342006834	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
546342006835	trimer interface [polypeptide binding]; other site
546342006836	dimer interface [polypeptide binding]; other site
546342006837	putative active site [active]
546342006838	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
546342006839	MPT binding site; other site
546342006840	trimer interface [polypeptide binding]; other site
546342006841	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
546342006842	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
546342006843	ATP binding site [chemical binding]; other site
546342006844	substrate interface [chemical binding]; other site
546342006845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342006846	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
546342006847	Walker A/P-loop; other site
546342006848	ATP binding site [chemical binding]; other site
546342006849	Q-loop/lid; other site
546342006850	ABC transporter signature motif; other site
546342006851	Walker B; other site
546342006852	D-loop; other site
546342006853	H-loop/switch region; other site
546342006854	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
546342006855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342006856	dimer interface [polypeptide binding]; other site
546342006857	conserved gate region; other site
546342006858	putative PBP binding loops; other site
546342006859	ABC-ATPase subunit interface; other site
546342006860	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
546342006861	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546342006862	substrate binding pocket [chemical binding]; other site
546342006863	membrane-bound complex binding site; other site
546342006864	hinge residues; other site
546342006865	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
546342006866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342006867	Coenzyme A binding pocket [chemical binding]; other site
546342006868	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
546342006869	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
546342006870	active site
546342006871	dimerization interface [polypeptide binding]; other site
546342006872	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
546342006873	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546342006874	intersubunit interface [polypeptide binding]; other site
546342006875	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
546342006876	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
546342006877	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
546342006878	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
546342006879	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
546342006880	alpha-gamma subunit interface [polypeptide binding]; other site
546342006881	beta-gamma subunit interface [polypeptide binding]; other site
546342006882	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
546342006883	gamma-beta subunit interface [polypeptide binding]; other site
546342006884	alpha-beta subunit interface [polypeptide binding]; other site
546342006885	urease subunit alpha; Reviewed; Region: ureC; PRK13207
546342006886	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
546342006887	subunit interactions [polypeptide binding]; other site
546342006888	active site
546342006889	flap region; other site
546342006890	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
546342006891	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
546342006892	dimer interface [polypeptide binding]; other site
546342006893	catalytic residues [active]
546342006894	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
546342006895	UreF; Region: UreF; pfam01730
546342006896	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546342006897	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
546342006898	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342006899	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342006900	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342006901	Helix-turn-helix domain; Region: HTH_18; pfam12833
546342006902	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
546342006903	Surface antigen [General function prediction only]; Region: COG3942
546342006904	CHAP domain; Region: CHAP; pfam05257
546342006905	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
546342006906	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
546342006907	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
546342006908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
546342006909	Surface antigen [General function prediction only]; Region: COG3942
546342006910	CHAP domain; Region: CHAP; pfam05257
546342006911	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
546342006912	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
546342006913	putative ligand binding site [chemical binding]; other site
546342006914	putative NAD binding site [chemical binding]; other site
546342006915	catalytic site [active]
546342006916	hypothetical protein; Provisional; Region: PRK06753
546342006917	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
546342006918	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
546342006919	Lysozyme subfamily 2; Region: LYZ2; smart00047
546342006920	Uncharacterized conserved protein [Function unknown]; Region: COG2427
546342006921	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
546342006922	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
546342006923	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
546342006924	4Fe-4S binding domain; Region: Fer4; pfam00037
546342006925	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
546342006926	[4Fe-4S] binding site [ion binding]; other site
546342006927	molybdopterin cofactor binding site; other site
546342006928	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
546342006929	molybdopterin cofactor binding site; other site
546342006930	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
546342006931	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
546342006932	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
546342006933	active site
546342006934	Predicted transcriptional regulator [Transcription]; Region: COG2378
546342006935	HTH domain; Region: HTH_11; pfam08279
546342006936	CAAX protease self-immunity; Region: Abi; pfam02517
546342006937	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
546342006938	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
546342006939	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
546342006940	putative active site [active]
546342006941	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
546342006942	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
546342006943	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342006944	active site
546342006945	motif I; other site
546342006946	motif II; other site
546342006947	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
546342006948	Sodium Bile acid symporter family; Region: SBF; pfam01758
546342006949	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
546342006950	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
546342006951	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
546342006952	active site turn [active]
546342006953	phosphorylation site [posttranslational modification]
546342006954	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
546342006955	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
546342006956	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
546342006957	putative active site [active]
546342006958	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
546342006959	putative hydrophobic ligand binding site [chemical binding]; other site
546342006960	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
546342006961	oxidoreductase; Provisional; Region: PRK07985
546342006962	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546342006963	NAD(P) binding site [chemical binding]; other site
546342006964	active site
546342006965	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
546342006966	amidohydrolase; Region: amidohydrolases; TIGR01891
546342006967	metal binding site [ion binding]; metal-binding site
546342006968	dimer interface [polypeptide binding]; other site
546342006969	imidazolonepropionase; Validated; Region: PRK09356
546342006970	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
546342006971	active site
546342006972	urocanate hydratase; Provisional; Region: PRK05414
546342006973	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546342006974	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546342006975	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
546342006976	dimerization interface [polypeptide binding]; other site
546342006977	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
546342006978	FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
546342006979	putative active site [active]
546342006980	putative Mg binding site [ion binding]; other site
546342006981	formimidoylglutamase; Provisional; Region: PRK13775
546342006982	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
546342006983	putative active site [active]
546342006984	putative metal binding site [ion binding]; other site
546342006985	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
546342006986	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
546342006987	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546342006988	active site
546342006989	dimer interface [polypeptide binding]; other site
546342006990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
546342006991	MOSC domain; Region: MOSC; pfam03473
546342006992	3-alpha domain; Region: 3-alpha; pfam03475
546342006993	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
546342006994	active site
546342006995	catalytic residues [active]
546342006996	Uncharacterized conserved protein [Function unknown]; Region: COG1742
546342006997	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
546342006998	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
546342006999	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342007000	Walker A/P-loop; other site
546342007001	ATP binding site [chemical binding]; other site
546342007002	Q-loop/lid; other site
546342007003	ABC transporter signature motif; other site
546342007004	Walker B; other site
546342007005	D-loop; other site
546342007006	H-loop/switch region; other site
546342007007	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
546342007008	Predicted membrane protein [Function unknown]; Region: COG3152
546342007009	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
546342007010	active site
546342007011	DNA binding site [nucleotide binding]
546342007012	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
546342007013	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
546342007014	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
546342007015	homotetramer interface [polypeptide binding]; other site
546342007016	FMN binding site [chemical binding]; other site
546342007017	homodimer contacts [polypeptide binding]; other site
546342007018	putative active site [active]
546342007019	putative substrate binding site [chemical binding]; other site
546342007020	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
546342007021	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
546342007022	oligomer interface [polypeptide binding]; other site
546342007023	metal binding site [ion binding]; metal-binding site
546342007024	metal binding site [ion binding]; metal-binding site
546342007025	putative Cl binding site [ion binding]; other site
546342007026	aspartate ring; other site
546342007027	basic sphincter; other site
546342007028	hydrophobic gate; other site
546342007029	periplasmic entrance; other site
546342007030	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
546342007031	active site
546342007032	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
546342007033	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
546342007034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007035	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
546342007036	putative substrate translocation pore; other site
546342007037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007038	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
546342007039	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
546342007040	HlyD family secretion protein; Region: HlyD_3; pfam13437
546342007041	lipoyl-biotinyl attachment site [posttranslational modification]; other site
546342007042	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
546342007043	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007044	putative substrate translocation pore; other site
546342007045	Predicted membrane protein [Function unknown]; Region: COG4640
546342007046	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
546342007047	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546342007048	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
546342007049	putative Zn2+ binding site [ion binding]; other site
546342007050	putative DNA binding site [nucleotide binding]; other site
546342007051	Uncharacterized conserved protein [Function unknown]; Region: COG1434
546342007052	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
546342007053	putative active site [active]
546342007054	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546342007055	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546342007056	Walker A/P-loop; other site
546342007057	ATP binding site [chemical binding]; other site
546342007058	Q-loop/lid; other site
546342007059	ABC transporter signature motif; other site
546342007060	Walker B; other site
546342007061	D-loop; other site
546342007062	H-loop/switch region; other site
546342007063	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
546342007064	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
546342007065	FtsX-like permease family; Region: FtsX; pfam02687
546342007066	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546342007067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342007068	active site
546342007069	phosphorylation site [posttranslational modification]
546342007070	intermolecular recognition site; other site
546342007071	dimerization interface [polypeptide binding]; other site
546342007072	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546342007073	DNA binding site [nucleotide binding]
546342007074	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546342007075	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
546342007076	dimerization interface [polypeptide binding]; other site
546342007077	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
546342007078	dimer interface [polypeptide binding]; other site
546342007079	phosphorylation site [posttranslational modification]
546342007080	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342007081	ATP binding site [chemical binding]; other site
546342007082	Mg2+ binding site [ion binding]; other site
546342007083	G-X-G motif; other site
546342007084	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
546342007085	LytTr DNA-binding domain; Region: LytTR; smart00850
546342007086	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
546342007087	Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
546342007088	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
546342007089	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
546342007090	L-lactate permease; Region: Lactate_perm; cl00701
546342007091	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
546342007092	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342007093	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
546342007094	Coenzyme A binding pocket [chemical binding]; other site
546342007095	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
546342007096	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
546342007097	NAD(P) binding site [chemical binding]; other site
546342007098	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342007099	Coenzyme A binding pocket [chemical binding]; other site
546342007100	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
546342007101	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546342007102	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342007103	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
546342007104	Predicted membrane protein [Function unknown]; Region: COG1511
546342007105	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
546342007106	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
546342007107	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
546342007108	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
546342007109	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
546342007110	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
546342007111	Cl binding site [ion binding]; other site
546342007112	oligomer interface [polypeptide binding]; other site
546342007113	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
546342007114	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
546342007115	active site turn [active]
546342007116	phosphorylation site [posttranslational modification]
546342007117	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
546342007118	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
546342007119	Transposase, Mutator family; Region: Transposase_mut; pfam00872
546342007120	MULE transposase domain; Region: MULE; pfam10551
546342007121	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
546342007122	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
546342007123	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
546342007124	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
546342007125	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
546342007126	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546342007127	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
546342007128	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
546342007129	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
546342007130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007131	putative substrate translocation pore; other site
546342007132	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
546342007133	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
546342007134	DNA binding residues [nucleotide binding]
546342007135	dimer interface [polypeptide binding]; other site
546342007136	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
546342007137	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
546342007138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342007139	active site
546342007140	phosphorylation site [posttranslational modification]
546342007141	intermolecular recognition site; other site
546342007142	dimerization interface [polypeptide binding]; other site
546342007143	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
546342007144	DNA binding residues [nucleotide binding]
546342007145	dimerization interface [polypeptide binding]; other site
546342007146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
546342007147	Histidine kinase; Region: HisKA_3; pfam07730
546342007148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342007149	ATP binding site [chemical binding]; other site
546342007150	Mg2+ binding site [ion binding]; other site
546342007151	G-X-G motif; other site
546342007152	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
546342007153	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
546342007154	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
546342007155	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
546342007156	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
546342007157	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
546342007158	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
546342007159	[4Fe-4S] binding site [ion binding]; other site
546342007160	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
546342007161	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
546342007162	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
546342007163	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
546342007164	molybdopterin cofactor binding site; other site
546342007165	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
546342007166	active site
546342007167	SAM binding site [chemical binding]; other site
546342007168	homodimer interface [polypeptide binding]; other site
546342007169	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
546342007170	[2Fe-2S] cluster binding site [ion binding]; other site
546342007171	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
546342007172	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546342007173	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
546342007174	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
546342007175	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
546342007176	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
546342007177	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
546342007178	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
546342007179	putative active site [active]
546342007180	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
546342007181	active site
546342007182	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
546342007183	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342007184	Coenzyme A binding pocket [chemical binding]; other site
546342007185	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
546342007186	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
546342007187	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
546342007188	putative hydrophobic ligand binding site [chemical binding]; other site
546342007189	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
546342007190	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
546342007191	intersubunit interface [polypeptide binding]; other site
546342007192	YodA lipocalin-like domain; Region: YodA; pfam09223
546342007193	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
546342007194	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
546342007195	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
546342007196	Thioredoxin; Region: Thioredoxin_4; cl17273
546342007197	FemAB family; Region: FemAB; pfam02388
546342007198	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
546342007199	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
546342007200	Walker A/P-loop; other site
546342007201	ATP binding site [chemical binding]; other site
546342007202	Q-loop/lid; other site
546342007203	ABC transporter signature motif; other site
546342007204	Walker B; other site
546342007205	D-loop; other site
546342007206	H-loop/switch region; other site
546342007207	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
546342007208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342007209	dimer interface [polypeptide binding]; other site
546342007210	conserved gate region; other site
546342007211	putative PBP binding loops; other site
546342007212	ABC-ATPase subunit interface; other site
546342007213	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
546342007214	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
546342007215	substrate binding pocket [chemical binding]; other site
546342007216	membrane-bound complex binding site; other site
546342007217	hinge residues; other site
546342007218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007219	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342007220	putative substrate translocation pore; other site
546342007221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007222	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546342007223	catalytic core [active]
546342007224	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
546342007225	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
546342007226	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
546342007227	B domain; Region: B; pfam02216
546342007228	B domain; Region: B; pfam02216
546342007229	C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
546342007230	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
546342007231	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
546342007232	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
546342007233	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
546342007234	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
546342007235	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
546342007236	catalytic residue [active]
546342007237	biotin synthase; Validated; Region: PRK06256
546342007238	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546342007239	FeS/SAM binding site; other site
546342007240	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
546342007241	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546342007242	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
546342007243	inhibitor-cofactor binding pocket; inhibition site
546342007244	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342007245	catalytic residue [active]
546342007246	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
546342007247	AAA domain; Region: AAA_26; pfam13500
546342007248	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
546342007249	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
546342007250	Walker A/P-loop; other site
546342007251	ATP binding site [chemical binding]; other site
546342007252	Q-loop/lid; other site
546342007253	ABC transporter signature motif; other site
546342007254	Walker B; other site
546342007255	D-loop; other site
546342007256	H-loop/switch region; other site
546342007257	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
546342007258	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
546342007259	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342007260	Walker A/P-loop; other site
546342007261	ATP binding site [chemical binding]; other site
546342007262	Q-loop/lid; other site
546342007263	ABC transporter signature motif; other site
546342007264	Walker B; other site
546342007265	D-loop; other site
546342007266	H-loop/switch region; other site
546342007267	Predicted membrane protein [Function unknown]; Region: COG2246
546342007268	GtrA-like protein; Region: GtrA; pfam04138
546342007269	glycerate kinase; Region: TIGR00045
546342007270	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
546342007271	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
546342007272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007273	putative substrate translocation pore; other site
546342007274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
546342007275	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
546342007276	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
546342007277	putative phosphoesterase; Region: acc_ester; TIGR03729
546342007278	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
546342007279	Spore germination protein; Region: Spore_permease; cl17796
546342007280	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
546342007281	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
546342007282	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
546342007283	Beta-lactamase; Region: Beta-lactamase; pfam00144
546342007284	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
546342007285	extended (e) SDRs; Region: SDR_e; cd08946
546342007286	NAD(P) binding site [chemical binding]; other site
546342007287	active site
546342007288	substrate binding site [chemical binding]; other site
546342007289	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
546342007290	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
546342007291	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
546342007292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007293	putative substrate translocation pore; other site
546342007294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342007296	dimer interface [polypeptide binding]; other site
546342007297	conserved gate region; other site
546342007298	ABC-ATPase subunit interface; other site
546342007299	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
546342007300	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
546342007301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342007302	dimer interface [polypeptide binding]; other site
546342007303	conserved gate region; other site
546342007304	putative PBP binding loops; other site
546342007305	ABC-ATPase subunit interface; other site
546342007306	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
546342007307	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
546342007308	Walker A/P-loop; other site
546342007309	ATP binding site [chemical binding]; other site
546342007310	Q-loop/lid; other site
546342007311	ABC transporter signature motif; other site
546342007312	Walker B; other site
546342007313	D-loop; other site
546342007314	H-loop/switch region; other site
546342007315	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
546342007316	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
546342007317	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
546342007318	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
546342007319	amino acid transporter; Region: 2A0306; TIGR00909
546342007320	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
546342007321	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
546342007322	substrate binding pocket [chemical binding]; other site
546342007323	catalytic triad [active]
546342007324	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
546342007325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007326	putative substrate translocation pore; other site
546342007327	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
546342007328	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
546342007329	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
546342007330	Walker A/P-loop; other site
546342007331	ATP binding site [chemical binding]; other site
546342007332	Q-loop/lid; other site
546342007333	ABC transporter signature motif; other site
546342007334	Walker B; other site
546342007335	D-loop; other site
546342007336	H-loop/switch region; other site
546342007337	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
546342007338	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
546342007339	oligomer interface [polypeptide binding]; other site
546342007340	active site
546342007341	metal binding site [ion binding]; metal-binding site
546342007342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115
546342007343	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
546342007344	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
546342007345	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
546342007346	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
546342007347	active site
546342007348	FMN binding site [chemical binding]; other site
546342007349	substrate binding site [chemical binding]; other site
546342007350	3Fe-4S cluster binding site [ion binding]; other site
546342007351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007352	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342007353	putative substrate translocation pore; other site
546342007354	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
546342007355	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546342007356	Walker A/P-loop; other site
546342007357	ATP binding site [chemical binding]; other site
546342007358	Q-loop/lid; other site
546342007359	ABC transporter signature motif; other site
546342007360	Walker B; other site
546342007361	D-loop; other site
546342007362	H-loop/switch region; other site
546342007363	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
546342007364	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
546342007365	Walker A/P-loop; other site
546342007366	ATP binding site [chemical binding]; other site
546342007367	Q-loop/lid; other site
546342007368	ABC transporter signature motif; other site
546342007369	Walker B; other site
546342007370	D-loop; other site
546342007371	H-loop/switch region; other site
546342007372	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
546342007373	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
546342007374	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
546342007375	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342007376	dimer interface [polypeptide binding]; other site
546342007377	conserved gate region; other site
546342007378	putative PBP binding loops; other site
546342007379	ABC-ATPase subunit interface; other site
546342007380	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
546342007381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
546342007382	dimer interface [polypeptide binding]; other site
546342007383	conserved gate region; other site
546342007384	putative PBP binding loops; other site
546342007385	ABC-ATPase subunit interface; other site
546342007386	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
546342007387	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
546342007388	substrate binding site [chemical binding]; other site
546342007389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
546342007390	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
546342007391	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
546342007392	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
546342007393	AbgT putative transporter family; Region: ABG_transport; pfam03806
546342007394	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
546342007395	Uncharacterized conserved protein [Function unknown]; Region: COG2128
546342007396	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
546342007397	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
546342007398	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
546342007399	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
546342007400	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
546342007401	classical (c) SDRs; Region: SDR_c; cd05233
546342007402	NAD(P) binding site [chemical binding]; other site
546342007403	active site
546342007404	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
546342007405	Protein of unknown function, DUF576; Region: DUF576; pfam04507
546342007406	Protein of unknown function, DUF576; Region: DUF576; pfam04507
546342007407	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
546342007408	PLD-like domain; Region: PLDc_2; pfam13091
546342007409	putative homodimer interface [polypeptide binding]; other site
546342007410	putative active site [active]
546342007411	catalytic site [active]
546342007412	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
546342007413	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
546342007414	ATP binding site [chemical binding]; other site
546342007415	putative Mg++ binding site [ion binding]; other site
546342007416	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
546342007417	nucleotide binding region [chemical binding]; other site
546342007418	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
546342007419	ATP-binding site [chemical binding]; other site
546342007420	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
546342007421	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
546342007422	active site
546342007423	8-oxo-dGMP binding site [chemical binding]; other site
546342007424	nudix motif; other site
546342007425	metal binding site [ion binding]; metal-binding site
546342007426	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
546342007427	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
546342007428	active site
546342007429	substrate binding site [chemical binding]; other site
546342007430	metal binding site [ion binding]; metal-binding site
546342007431	H+ Antiporter protein; Region: 2A0121; TIGR00900
546342007432	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342007433	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546342007434	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342007435	Transcriptional regulators [Transcription]; Region: MarR; COG1846
546342007436	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
546342007437	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
546342007438	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
546342007439	active site
546342007440	tetramer interface; other site
546342007441	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
546342007442	Fibronectin binding repeat; Region: Fn_bind; pfam02986
546342007443	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
546342007444	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
546342007445	Fibronectin binding repeat; Region: Fn_bind; pfam02986
546342007446	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
546342007447	GntP family permease; Region: GntP_permease; pfam02447
546342007448	fructuronate transporter; Provisional; Region: PRK10034; cl15264
546342007449	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
546342007450	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
546342007451	N- and C-terminal domain interface [polypeptide binding]; other site
546342007452	active site
546342007453	catalytic site [active]
546342007454	metal binding site [ion binding]; metal-binding site
546342007455	carbohydrate binding site [chemical binding]; other site
546342007456	ATP binding site [chemical binding]; other site
546342007457	Transcriptional regulators [Transcription]; Region: GntR; COG1802
546342007458	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
546342007459	DNA-binding site [nucleotide binding]; DNA binding site
546342007460	FCD domain; Region: FCD; pfam07729
546342007461	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
546342007462	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
546342007463	DNA binding residues [nucleotide binding]
546342007464	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
546342007465	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
546342007466	synthetase active site [active]
546342007467	NTP binding site [chemical binding]; other site
546342007468	metal binding site [ion binding]; metal-binding site
546342007469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
546342007470	Predicted membrane protein [Function unknown]; Region: COG1289
546342007471	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
546342007472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007473	D-galactonate transporter; Region: 2A0114; TIGR00893
546342007474	putative substrate translocation pore; other site
546342007475	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
546342007476	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
546342007477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
546342007478	Major Facilitator Superfamily; Region: MFS_1; pfam07690
546342007479	putative substrate translocation pore; other site
546342007480	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546342007481	MarR family; Region: MarR; pfam01047
546342007482	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
546342007483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342007484	Walker A/P-loop; other site
546342007485	ATP binding site [chemical binding]; other site
546342007486	Q-loop/lid; other site
546342007487	ABC transporter signature motif; other site
546342007488	Walker B; other site
546342007489	D-loop; other site
546342007490	H-loop/switch region; other site
546342007491	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
546342007492	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
546342007493	Uncharacterized membrane protein [Function unknown]; Region: COG3949
546342007494	Predicted esterase [General function prediction only]; Region: COG0400
546342007495	putative hydrolase; Provisional; Region: PRK11460
546342007496	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
546342007497	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546342007498	Zn binding site [ion binding]; other site
546342007499	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
546342007500	Zn binding site [ion binding]; other site
546342007501	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546342007502	MarR family; Region: MarR; pfam01047
546342007503	Predicted acetyltransferase [General function prediction only]; Region: COG2388
546342007504	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
546342007505	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
546342007506	putative metal binding site [ion binding]; other site
546342007507	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
546342007508	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
546342007509	dimer interface [polypeptide binding]; other site
546342007510	FMN binding site [chemical binding]; other site
546342007511	D-lactate dehydrogenase; Provisional; Region: PRK12480
546342007512	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
546342007513	homodimer interface [polypeptide binding]; other site
546342007514	ligand binding site [chemical binding]; other site
546342007515	NAD binding site [chemical binding]; other site
546342007516	catalytic site [active]
546342007517	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
546342007518	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
546342007519	active site
546342007520	motif I; other site
546342007521	motif II; other site
546342007522	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
546342007523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
546342007524	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
546342007525	Walker A/P-loop; other site
546342007526	ATP binding site [chemical binding]; other site
546342007527	Q-loop/lid; other site
546342007528	ABC transporter signature motif; other site
546342007529	Walker B; other site
546342007530	D-loop; other site
546342007531	H-loop/switch region; other site
546342007532	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
546342007533	active site
546342007534	catalytic site [active]
546342007535	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
546342007536	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342007537	Coenzyme A binding pocket [chemical binding]; other site
546342007538	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
546342007539	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
546342007540	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
546342007541	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
546342007542	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
546342007543	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
546342007544	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
546342007545	EamA-like transporter family; Region: EamA; pfam00892
546342007546	EamA-like transporter family; Region: EamA; pfam00892
546342007547	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
546342007548	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
546342007549	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
546342007550	catalytic residues [active]
546342007551	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
546342007552	active site
546342007553	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
546342007554	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
546342007555	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
546342007556	active site turn [active]
546342007557	phosphorylation site [posttranslational modification]
546342007558	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
546342007559	HPr interaction site; other site
546342007560	glycerol kinase (GK) interaction site [polypeptide binding]; other site
546342007561	active site
546342007562	phosphorylation site [posttranslational modification]
546342007563	pyruvate oxidase; Provisional; Region: PRK08611
546342007564	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
546342007565	PYR/PP interface [polypeptide binding]; other site
546342007566	tetramer interface [polypeptide binding]; other site
546342007567	dimer interface [polypeptide binding]; other site
546342007568	TPP binding site [chemical binding]; other site
546342007569	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
546342007570	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
546342007571	TPP-binding site [chemical binding]; other site
546342007572	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
546342007573	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
546342007574	Transcriptional regulator [Transcription]; Region: LysR; COG0583
546342007575	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
546342007576	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
546342007577	putative dimerization interface [polypeptide binding]; other site
546342007578	Surface antigen [General function prediction only]; Region: COG3942
546342007579	CHAP domain; Region: CHAP; pfam05257
546342007580	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
546342007581	homodimer interface [polypeptide binding]; other site
546342007582	catalytic residues [active]
546342007583	NAD binding site [chemical binding]; other site
546342007584	substrate binding pocket [chemical binding]; other site
546342007585	flexible flap; other site
546342007586	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
546342007587	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
546342007588	dimer interface [polypeptide binding]; other site
546342007589	active site
546342007590	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
546342007591	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
546342007592	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
546342007593	DNA binding site [nucleotide binding]
546342007594	active site
546342007595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342007596	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
546342007597	Walker A motif; other site
546342007598	ATP binding site [chemical binding]; other site
546342007599	Walker B motif; other site
546342007600	arginine finger; other site
546342007601	UvrB/uvrC motif; Region: UVR; pfam02151
546342007602	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
546342007603	Walker A motif; other site
546342007604	ATP binding site [chemical binding]; other site
546342007605	Walker B motif; other site
546342007606	arginine finger; other site
546342007607	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
546342007608	Virus attachment protein p12 family; Region: P12; pfam12669
546342007609	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
546342007610	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
546342007611	G1 box; other site
546342007612	GTP/Mg2+ binding site [chemical binding]; other site
546342007613	Switch I region; other site
546342007614	G2 box; other site
546342007615	G3 box; other site
546342007616	Switch II region; other site
546342007617	G4 box; other site
546342007618	G5 box; other site
546342007619	Nucleoside recognition; Region: Gate; pfam07670
546342007620	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
546342007621	Nucleoside recognition; Region: Gate; pfam07670
546342007622	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
546342007623	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
546342007624	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
546342007625	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546342007626	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
546342007627	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
546342007628	Glutamate binding site [chemical binding]; other site
546342007629	homodimer interface [polypeptide binding]; other site
546342007630	NAD binding site [chemical binding]; other site
546342007631	catalytic residues [active]
546342007632	maltose O-acetyltransferase; Provisional; Region: PRK10092
546342007633	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
546342007634	active site
546342007635	substrate binding site [chemical binding]; other site
546342007636	trimer interface [polypeptide binding]; other site
546342007637	CoA binding site [chemical binding]; other site
546342007638	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
546342007639	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546342007640	metal-binding site [ion binding]
546342007641	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
546342007642	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546342007643	metal-binding site [ion binding]
546342007644	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
546342007645	Soluble P-type ATPase [General function prediction only]; Region: COG4087
546342007646	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
546342007647	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
546342007648	metal-binding site [ion binding]
546342007649	D-lactate dehydrogenase; Validated; Region: PRK08605
546342007650	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
546342007651	homodimer interface [polypeptide binding]; other site
546342007652	ligand binding site [chemical binding]; other site
546342007653	NAD binding site [chemical binding]; other site
546342007654	catalytic site [active]
546342007655	transaminase; Reviewed; Region: PRK08068
546342007656	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546342007657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342007658	homodimer interface [polypeptide binding]; other site
546342007659	catalytic residue [active]
546342007660	phytoene desaturase; Region: crtI_fam; TIGR02734
546342007661	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546342007662	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
546342007663	active site lid residues [active]
546342007664	substrate binding pocket [chemical binding]; other site
546342007665	catalytic residues [active]
546342007666	substrate-Mg2+ binding site; other site
546342007667	aspartate-rich region 1; other site
546342007668	aspartate-rich region 2; other site
546342007669	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
546342007670	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
546342007671	active site
546342007672	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
546342007673	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
546342007674	Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237
546342007675	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
546342007676	Surface antigen [General function prediction only]; Region: COG3942
546342007677	CHAP domain; Region: CHAP; pfam05257
546342007678	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
546342007679	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
546342007680	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
546342007681	catalytic triad [active]
546342007682	catalytic triad [active]
546342007683	oxyanion hole [active]
546342007684	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
546342007685	N-acetyl-D-glucosamine binding site [chemical binding]; other site
546342007686	catalytic residue [active]
546342007687	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
546342007688	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
546342007689	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546342007690	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546342007691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
546342007692	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
546342007693	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546342007694	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
546342007695	NmrA-like family; Region: NmrA; pfam05368
546342007696	NADP binding site [chemical binding]; other site
546342007697	active site
546342007698	regulatory binding site [polypeptide binding]; other site
546342007699	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
546342007700	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546342007701	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546342007702	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
546342007703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
546342007704	NAD(P) binding site [chemical binding]; other site
546342007705	active site
546342007706	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
546342007707	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
546342007708	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
546342007709	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
546342007710	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
546342007711	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
546342007712	Nucleoside recognition; Region: Gate; pfam07670
546342007713	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
546342007714	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
546342007715	Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842
546342007716	Helix-turn-helix domain; Region: HTH_28; pfam13518
546342007717	Winged helix-turn helix; Region: HTH_29; pfam13551
546342007718	Integrase core domain; Region: rve; pfam00665
546342007719	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
546342007720	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
546342007721	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
546342007722	catalytic residues [active]
546342007723	catalytic nucleophile [active]
546342007724	Presynaptic Site I dimer interface [polypeptide binding]; other site
546342007725	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
546342007726	Synaptic Flat tetramer interface [polypeptide binding]; other site
546342007727	Synaptic Site I dimer interface [polypeptide binding]; other site
546342007728	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
546342007729	DNA-binding interface [nucleotide binding]; DNA binding site
546342007730	Predicted transcriptional regulator [Transcription]; Region: COG3682
546342007731	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
546342007732	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
546342007733	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
546342007734	beta-lactamase TEM; Provisional; Region: PRK15442
546342007735	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
546342007736	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
546342007737	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
546342007738	Surface antigen [General function prediction only]; Region: COG3942
546342007739	CHAP domain; Region: CHAP; pfam05257
546342007740	ribonuclease E; Reviewed; Region: rne; PRK10811
546342007741	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
546342007742	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
546342007743	AAA-like domain; Region: AAA_10; pfam12846
546342007744	TcpE family; Region: TcpE; pfam12648
546342007745	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
546342007746	Replication initiation factor; Region: Rep_trans; pfam02486
546342007747	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
546342007748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495
546342007749	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
546342007750	Phosphotransferase enzyme family; Region: APH; pfam01636
546342007751	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
546342007752	active site
546342007753	ATP binding site [chemical binding]; other site
546342007754	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
546342007755	active site
546342007756	ATP binding site [chemical binding]; other site
546342007757	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
546342007758	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
546342007759	quinone interaction residues [chemical binding]; other site
546342007760	active site
546342007761	catalytic residues [active]
546342007762	FMN binding site [chemical binding]; other site
546342007763	substrate binding site [chemical binding]; other site
546342007764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
546342007765	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
546342007766	dimer interface [polypeptide binding]; other site
546342007767	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
546342007768	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546342007769	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546342007770	Predicted acyl esterases [General function prediction only]; Region: COG2936
546342007771	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
546342007772	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
546342007773	tetramerization interface [polypeptide binding]; other site
546342007774	active site
546342007775	pantoate--beta-alanine ligase; Region: panC; TIGR00018
546342007776	Pantoate-beta-alanine ligase; Region: PanC; cd00560
546342007777	active site
546342007778	ATP-binding site [chemical binding]; other site
546342007779	pantoate-binding site; other site
546342007780	HXXH motif; other site
546342007781	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
546342007782	oligomerization interface [polypeptide binding]; other site
546342007783	active site
546342007784	metal binding site [ion binding]; metal-binding site
546342007785	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
546342007786	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
546342007787	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
546342007788	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
546342007789	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
546342007790	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
546342007791	tetramer (dimer of dimers) interface [polypeptide binding]; other site
546342007792	NAD binding site [chemical binding]; other site
546342007793	dimer interface [polypeptide binding]; other site
546342007794	substrate binding site [chemical binding]; other site
546342007795	amino acid transporter; Region: 2A0306; TIGR00909
546342007796	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
546342007797	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
546342007798	inhibitor-cofactor binding pocket; inhibition site
546342007799	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342007800	catalytic residue [active]
546342007801	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
546342007802	catalytic residue [active]
546342007803	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
546342007804	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
546342007805	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
546342007806	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
546342007807	acyl-activating enzyme (AAE) consensus motif; other site
546342007808	AMP binding site [chemical binding]; other site
546342007809	active site
546342007810	CoA binding site [chemical binding]; other site
546342007811	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
546342007812	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
546342007813	choline dehydrogenase; Validated; Region: PRK02106
546342007814	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
546342007815	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
546342007816	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
546342007817	tetramerization interface [polypeptide binding]; other site
546342007818	NAD(P) binding site [chemical binding]; other site
546342007819	catalytic residues [active]
546342007820	Predicted transcriptional regulators [Transcription]; Region: COG1510
546342007821	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
546342007822	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
546342007823	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
546342007824	FeS/SAM binding site; other site
546342007825	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
546342007826	Class III ribonucleotide reductase; Region: RNR_III; cd01675
546342007827	effector binding site; other site
546342007828	active site
546342007829	Zn binding site [ion binding]; other site
546342007830	glycine loop; other site
546342007831	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
546342007832	Citrate transporter; Region: CitMHS; pfam03600
546342007833	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
546342007834	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
546342007835	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
546342007836	Flavodoxin; Region: Flavodoxin_1; pfam00258
546342007837	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
546342007838	FAD binding pocket [chemical binding]; other site
546342007839	FAD binding motif [chemical binding]; other site
546342007840	catalytic residues [active]
546342007841	NAD binding pocket [chemical binding]; other site
546342007842	phosphate binding motif [ion binding]; other site
546342007843	beta-alpha-beta structure motif; other site
546342007844	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
546342007845	catalytic residues [active]
546342007846	dimer interface [polypeptide binding]; other site
546342007847	FtsX-like permease family; Region: FtsX; pfam02687
546342007848	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546342007849	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546342007850	Walker A/P-loop; other site
546342007851	ATP binding site [chemical binding]; other site
546342007852	Q-loop/lid; other site
546342007853	ABC transporter signature motif; other site
546342007854	Walker B; other site
546342007855	D-loop; other site
546342007856	H-loop/switch region; other site
546342007857	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
546342007858	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
546342007859	ATP binding site [chemical binding]; other site
546342007860	Mg2+ binding site [ion binding]; other site
546342007861	G-X-G motif; other site
546342007862	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
546342007863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
546342007864	active site
546342007865	phosphorylation site [posttranslational modification]
546342007866	intermolecular recognition site; other site
546342007867	dimerization interface [polypeptide binding]; other site
546342007868	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
546342007869	DNA binding site [nucleotide binding]
546342007870	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
546342007871	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
546342007872	dimer interface [polypeptide binding]; other site
546342007873	active site
546342007874	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
546342007875	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
546342007876	MarR family; Region: MarR_2; pfam12802
546342007877	Predicted esterase [General function prediction only]; Region: COG0627
546342007878	S-formylglutathione hydrolase; Region: PLN02442
546342007879	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
546342007880	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
546342007881	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
546342007882	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
546342007883	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
546342007884	ligand binding site [chemical binding]; other site
546342007885	flexible hinge region; other site
546342007886	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
546342007887	carbamate kinase; Reviewed; Region: PRK12686
546342007888	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
546342007889	putative substrate binding site [chemical binding]; other site
546342007890	nucleotide binding site [chemical binding]; other site
546342007891	nucleotide binding site [chemical binding]; other site
546342007892	homodimer interface [polypeptide binding]; other site
546342007893	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
546342007894	ornithine carbamoyltransferase; Validated; Region: PRK02102
546342007895	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
546342007896	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
546342007897	arginine deiminase; Provisional; Region: PRK01388
546342007898	Arginine repressor [Transcription]; Region: ArgR; COG1438
546342007899	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
546342007900	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
546342007901	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
546342007902	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
546342007903	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
546342007904	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
546342007905	active site
546342007906	Zn binding site [ion binding]; other site
546342007907	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
546342007908	HTH domain; Region: HTH_11; pfam08279
546342007909	PRD domain; Region: PRD; pfam00874
546342007910	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
546342007911	active site
546342007912	P-loop; other site
546342007913	phosphorylation site [posttranslational modification]
546342007914	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
546342007915	active site
546342007916	phosphorylation site [posttranslational modification]
546342007917	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
546342007918	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
546342007919	active site
546342007920	P-loop; other site
546342007921	phosphorylation site [posttranslational modification]
546342007922	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
546342007923	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
546342007924	active site
546342007925	phosphorylation site [posttranslational modification]
546342007926	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
546342007927	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
546342007928	Predicted membrane protein [Function unknown]; Region: COG1511
546342007929	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
546342007930	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
546342007931	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
546342007932	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
546342007933	CHAP domain; Region: CHAP; pfam05257
546342007934	Isochorismatase family; Region: Isochorismatase; pfam00857
546342007935	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
546342007936	catalytic triad [active]
546342007937	conserved cis-peptide bond; other site
546342007938	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
546342007939	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546342007940	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
546342007941	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
546342007942	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
546342007943	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
546342007944	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
546342007945	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
546342007946	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
546342007947	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
546342007948	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
546342007949	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
546342007950	SecY translocase; Region: SecY; pfam00344
546342007951	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
546342007952	legume lectins; Region: lectin_L-type; cd01951
546342007953	homotetramer interaction site [polypeptide binding]; other site
546342007954	carbohydrate binding site [chemical binding]; other site
546342007955	metal binding site [ion binding]; metal-binding site
546342007956	Putative Ig domain; Region: He_PIG; pfam05345
546342007957	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
546342007958	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
546342007959	methionine sulfoxide reductase A; Provisional; Region: PRK05528
546342007960	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
546342007961	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
546342007962	Coenzyme A binding pocket [chemical binding]; other site
546342007963	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
546342007964	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
546342007965	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
546342007966	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
546342007967	Chain length determinant protein; Region: Wzz; cl15801
546342007968	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
546342007969	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
546342007970	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
546342007971	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
546342007972	DXD motif; other site
546342007973	intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
546342007974	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
546342007975	Acyltransferase family; Region: Acyl_transf_3; pfam01757
546342007976	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
546342007977	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
546342007978	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
546342007979	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
546342007980	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
546342007981	metal binding site [ion binding]; metal-binding site
546342007982	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
546342007983	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
546342007984	substrate binding site [chemical binding]; other site
546342007985	glutamase interaction surface [polypeptide binding]; other site
546342007986	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
546342007987	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
546342007988	catalytic residues [active]
546342007989	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
546342007990	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
546342007991	putative active site [active]
546342007992	oxyanion strand; other site
546342007993	catalytic triad [active]
546342007994	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
546342007995	putative active site pocket [active]
546342007996	4-fold oligomerization interface [polypeptide binding]; other site
546342007997	metal binding residues [ion binding]; metal-binding site
546342007998	3-fold/trimer interface [polypeptide binding]; other site
546342007999	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
546342008000	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
546342008001	pyridoxal 5'-phosphate binding site [chemical binding]; other site
546342008002	homodimer interface [polypeptide binding]; other site
546342008003	catalytic residue [active]
546342008004	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
546342008005	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
546342008006	NAD binding site [chemical binding]; other site
546342008007	dimerization interface [polypeptide binding]; other site
546342008008	product binding site; other site
546342008009	substrate binding site [chemical binding]; other site
546342008010	zinc binding site [ion binding]; other site
546342008011	catalytic residues [active]
546342008012	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
546342008013	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
546342008014	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
546342008015	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
546342008016	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
546342008017	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
546342008018	putative active site [active]
546342008019	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
546342008020	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
546342008021	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
546342008022	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
546342008023	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
546342008024	Walker A/P-loop; other site
546342008025	ATP binding site [chemical binding]; other site
546342008026	Q-loop/lid; other site
546342008027	ABC transporter signature motif; other site
546342008028	Walker B; other site
546342008029	D-loop; other site
546342008030	H-loop/switch region; other site
546342008031	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
546342008032	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
546342008033	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
546342008034	Walker A/P-loop; other site
546342008035	ATP binding site [chemical binding]; other site
546342008036	Q-loop/lid; other site
546342008037	ABC transporter signature motif; other site
546342008038	Walker B; other site
546342008039	D-loop; other site
546342008040	H-loop/switch region; other site
546342008041	hypothetical protein; Provisional; Region: PRK13661
546342008042	Uncharacterized conserved protein [Function unknown]; Region: COG1912
546342008043	Uncharacterized conserved protein [Function unknown]; Region: COG2353
546342008044	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
546342008045	Strictosidine synthase; Region: Str_synth; pfam03088
546342008046	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
546342008047	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
546342008048	active site residue [active]
546342008049	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
546342008050	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
546342008051	putative substrate binding pocket [chemical binding]; other site
546342008052	AC domain interface; other site
546342008053	catalytic triad [active]
546342008054	AB domain interface; other site
546342008055	interchain disulfide; other site
546342008056	DinB superfamily; Region: DinB_2; pfam12867
546342008057	Collagen binding domain; Region: Collagen_bind; pfam05737
546342008058	Cna protein B-type domain; Region: Cna_B; pfam05738
546342008059	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
546342008060	domain interaction interfaces [polypeptide binding]; other site
546342008061	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
546342008062	domain interaction interfaces [polypeptide binding]; other site
546342008063	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
546342008064	domain interaction interfaces [polypeptide binding]; other site
546342008065	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
546342008066	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
546342008067	transmembrane helices; other site
546342008068	Predicted permeases [General function prediction only]; Region: RarD; COG2962
546342008069	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
546342008070	hypothetical protein; Provisional; Region: PRK07758
546342008071	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
546342008072	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
546342008073	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
546342008074	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
546342008075	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
546342008076	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
546342008077	Walker A/P-loop; other site
546342008078	ATP binding site [chemical binding]; other site
546342008079	Q-loop/lid; other site
546342008080	ABC transporter signature motif; other site
546342008081	Walker B; other site
546342008082	D-loop; other site
546342008083	H-loop/switch region; other site
546342008084	FtsX-like permease family; Region: FtsX; pfam02687
546342008085	Integrase core domain; Region: rve_3; cl15866
546342008086	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
546342008087	active site
546342008088	catalytic residues [active]
546342008089	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
546342008090	DNA-binding site [nucleotide binding]; DNA binding site
546342008091	RNA-binding motif; other site
546342008092	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
546342008093	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
546342008094	non-specific DNA binding site [nucleotide binding]; other site
546342008095	salt bridge; other site
546342008096	sequence-specific DNA binding site [nucleotide binding]; other site
546342008097	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
546342008098	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
546342008099	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
546342008100	ParB-like nuclease domain; Region: ParBc; pfam02195
546342008101	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
546342008102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
546342008103	S-adenosylmethionine binding site [chemical binding]; other site
546342008104	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
546342008105	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
546342008106	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
546342008107	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
546342008108	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
546342008109	trmE is a tRNA modification GTPase; Region: trmE; cd04164
546342008110	G1 box; other site
546342008111	GTP/Mg2+ binding site [chemical binding]; other site
546342008112	Switch I region; other site
546342008113	G2 box; other site
546342008114	Switch II region; other site
546342008115	G3 box; other site
546342008116	G4 box; other site
546342008117	G5 box; other site
546342008118	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
546342008119	ribonuclease P; Reviewed; Region: rnpA; PRK00499
546342008120	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399