-- dump date 20140620_074000 -- class Genbank::CDS -- table cds_note -- id note YP_005738179.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_005738183.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_005738185.1 Predicted branched-chain amino acid permease (azaleucine resistance), AzlC YP_005738193.1 also known as vicR and yycF YP_005738194.1 Also known as VicK and YycG YP_005738196.1 Possible negative regulator of walKR two-component response regulator YP_005738200.1 some domain identity with chromosome segregation proteins YP_005738224.1 contains HNH endonuclease signature YP_005738227.1 Pathogenicity island SaPIn2 YP_005738228.1 Full length version of CDS. Saa_6159_00033 is truncated pseudogene version. YP_005738231.1 Ortholog in another non-aureus Staph, adjacent to large stop codon rich intergenic region, perhaps ncRNA. YP_005738234.1 major facilitator superfamily multidrug: cation symporter YP_005738245.1 Some domain similarity with dienelactone hydrolase; see paralog SAA6159_00213. YP_005738251.1 some domain identity with lipases YP_005738256.1 predicted nucleoside-diphosphate-sugar epimerases YP_005738260.1 Some domain similarity with protein of unknown function (DUF1648) YP_005738267.1 identified by match to protein family HMM PF00291 YP_005738301.1 identified by match to protein family HMM PF02811 YP_005738305.1 identified by match to protein family HMM PF02350; match to protein family HMM TIGR00236 YP_005738324.1 similar to acyl-CoA dehydrogenase family protein YP_005738340.1 similar to PTS system sucrose-specific IIBC component YP_005738341.1 identified by match to protein family HMM PF01380; match to protein family HMM PF01418 YP_005738345.1 contains a RES domain of 3 highly conserved polar groups that could form an active site YP_005738351.1 Staphylococcus tandem lipoproteins are predicted lipoproteins (mostly), found in Staphylococcus aureus in several different tandem clusters in pathogenicity islands. Members are also found, clustered, in Staphylococcus epidermidis. YP_005738369.1 Some similarity with Staphylococcal complement inhibitor SCIN YP_005738379.1 Some domain similarity with dienelactone hydrolase; see paralog SAA6159_00075. YP_005738394.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesi YP_005738398.1 involved in isoprenoid and isopentenyl-PP biosynthesis YP_005738405.1 negatively regulates murein hydrolase activity YP_005738419.1 member of linear amide C-N hydrolase / choloylglycine hydrolase family YP_005738420.1 also called lysostaphin YP_005738429.1 Contains a WXG domain (from esxA proteins) YP_005738431.1 Some similarity with Firmicute eSAT-6 protein secretion system EssA YP_005738452.1 contains phosphotransferase system fructose-specific IIC component domain YP_005738462.1 identified by similarity to EGAD:17843; match to protein family HMM PF04650; match to protein family HMM TIGR01168 YP_005738463.1 some domain similarity with lipase, esterase, hydrolase YP_005738468.1 some similarity to NAD-dependent protein deacetylases, SIR2 family YP_005738474.1 MepR represses expression of MepA and MepB as well as autoregulating its own expression YP_005738475.1 part of mepABR system YP_005738495.1 potentially involved in antibiotic synthesis YP_005738508.1 Some domain similarity with Abortive infection bacteriophage resistance protein YP_005738538.1 Domain similarity with Protein of unknown function (DUF1304) YP_005738543.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_005738549.1 Pathogenicity island SaPIn2 YP_005738557.1 identified by match to protein family HMM PF04507; match to protein family HMM TIGR01742 YP_005738559.1 identified by match to protein family HMM PF04507; match to protein family HMM TIGR01742 YP_005738560.1 identified by match to protein family HMM PF04507; match to protein family HMM TIGR01742 YP_005738578.1 identified by match to protein family HMM PF00005 YP_005738581.1 identified by match to protein family HMM PF01476; match to protein family HMM PF05257 YP_005738600.1 KEGG: sav:SAV0484 probable DNA polymerase III delta prime subunit YP_005738601.1 Contains a IPSP1 domainn and in other S. aureus genomes this CDS has been termed 'PSP1 domain protein'. YP_005738613.1 may also be involved in the regulation of purine biosynthesis YP_005738617.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress respon YP_005738623.1 identified by similarity to EGAD:12437; match to protein family HMM PF04977 YP_005738649.1 identified by similarity to EGAD:14028; match to protein family HMM PF05991 YP_005738651.1 forms a complex with SecY and SecG to which secA binds YP_005738656.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulat YP_005738658.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_005738668.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_005738686.1 involved in the final step of pyrimidine biosynthesis YP_005738692.1 KEGG: sao:SAOUHSC_00559 hypothetical protein. Called vraC in Saa_SO385 YP_005738711.1 N-term homology to Bacillus transposase protein YP_005738718.1 contains a HD sub domain YP_005738719.1 YwhD familly protein YP_005738733.1 Unknown function YP_005738735.1 phage integrase family protein YP_005738736.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_005738737.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_005738738.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_005738739.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; in S. meliloti it is known to be involved specifica YP_005738740.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_005738741.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_005738742.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_005738747.1 identified by similarity to GP:1617434; match to protein family HMM PF01325; match to protein family HMM PF02742; match to protein family HMM PF04023 YP_005738788.1 Domain similarity with Uncharacterized membrane-bound protein conserved in bacteria YP_005738790.1 has Pfam IncA domain due to tandem 6-mer repeats YP_005738796.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_005738799.1 identified by match to protein family HMM PF01047 YP_005738820.1 Some domain similarity with DoxX YP_005738821.1 contains signal peptide sequence YP_005738837.1 identified by similarity to EGAD:107442; match to protein family HMM PF06941 YP_005738839.1 identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147 YP_005738849.1 lipoprotein, similar to ferrichrome ABC transporter YP_005738861.1 identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762 YP_005738867.1 Some domain similarity with CHAP and PRK08581 (amidase) and, lysM (lysin motif). YP_005738880.1 2-phospho-L-lactate transferase (CofD) related protein YP_005738892.1 SecG forms a complex with SecY and SecE. SecA then recruits the SecYEG complex to form an active protein translocation channel. YP_005738896.1 Some domain similarity with SpoIIM (uncharacterized membrane protein) and DUF95 (integral membrane protein) YP_005738901.1 secreted von Willebrand factor-binding protein precursor YP_005738903.1 KEGG: sav:SAV0814 hypothetical protein YP_005738905.1 identified by match to protein family HMM PF00313 YP_005738911.1 Domain similarity with DUF1250 (Protein of unknown function) YP_005738925.1 identified by match to protein family HMM PF00005 YP_005738939.1 identified by similarity to GP:10176077; match to protein family HMM PF01925 YP_005738941.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_005738968.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_005738996.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters YP_005739000.1 PFAM: binding-protein-dependent transport systems inner membrane component KEGG: sao:SAOUHSC_00923 hypothetical protein YP_005739001.1 identified by match to protein family HMM PF00528 YP_005739002.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter domain protein SMART: AAA ATPase KEGG: sao:SAOUHSC_00925 hypothetical protein YP_005739004.1 PFAM: extracellular solute-binding protein family 5 KEGG: sav:SAV0990 hypothetical protein, similar to peptide binding protein OppA YP_005739009.1 PFAM: extracellular solute-binding protein family 5 KEGG: sav:SAV0990 hypothetical protein, similar to peptide binding protein OppA YP_005739020.1 catalyzes the phosphorylation of NAD to NADP YP_005739024.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_005739025.1 member of the PurR regulon YP_005739028.1 Some domain similarity with 2'-5' RNA ligase (Translation, ribosomal structure and biogenesis) YP_005739038.1 identified by match to protein family HMM PF06338 YP_005739039.1 contains and IDEAL PFAM doman YP_005739045.1 contains an N-terminal signal sequence YP_005739051.1 conatins a iron-dicitrate transporter substrate-binding subunit domain, identified by match to protein family HMM PF01497 YP_005739055.1 systematic name is 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_005739060.1 Some domain similarity with Staphostatin B and A YP_005739065.1 Identified by match to protein family HMM PF01047. Domain similarity with Mar proteins (multiple antibiotic resistance, a non-specific resistance system). YP_005739070.1 identified by match to protein family HMM PF00144 YP_005739095.1 Small domain similarity with Uncharacterized protein/domain associated with GTPases (Function unknown). YP_005739096.1 part of PTS system YP_005739099.1 identified by match to protein family HMM PF01654 YP_005739151.1 an endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_005739155.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange YP_005739164.1 Some domain similarity with transport system component and guanosine 5'-monophosphate oxidoreductase. YP_005739177.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_005739205.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_005739230.1 Domain similarity with thiamine pyrophosphokinase YP_005739236.1 poorly understood protein involved in fatty acid and phospholipid biosynthesis YP_005739251.1 Domain similarity with Bacterial membrane protein YfhO YP_005739259.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_005739300.1 Domain similarity with uncharacterized protein YP_005739303.1 Domain similarity with ThiW, Thiamine-precursor transporter protein YP_005739314.1 contains a Restriction endonuclease domain (PFAM:PF04471.5) also YP_005739322.1 adjacent to tranposase YP_005739343.1 contains two transmembrane domains and possible signal peptide YP_005739355.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the YP_005739356.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are presen YP_005739357.1 guanosine 5'-monophosphate oxidoreductase YP_005739372.1 identified by match to protein family HMM PF02660; match to protein family HMM TIGR00023 YP_005739379.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_005739390.1 considered essential for expression of methicillin resistance YP_005739391.1 considered essential for expression of methicillin resistance YP_005739392.1 Some domain similarity with Macoilin and NADH dehydrogenase subunit YP_005739394.1 Domain similarity with SWIM zinc finger, mal_quin_oxido (membrane-associated enzyme) and, fliI, flagellum-specific ATP synthase YP_005739399.1 Some domain similarity with H_PPasem (Inorganic H+ pyrophosphatase), and DUF697, Family of unknown function (DUF697) YP_005739422.1 This family consists of several prokaryotic TelA like proteins. TelA and KlA are associated with tellurite resistance and plasmid fertility inhibition. YP_005739434.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_005739440.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_005739441.1 identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762 YP_005739455.1 Domain similarity with Dynamin_N, MMR_HSR1 (GTPase of unknown function), Era (E. coli Ras-like protein-like). YP_005739463.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC YP_005739475.1 Domain similarity with protein of unknown function (DUF1405) YP_005739478.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_005739484.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_005739497.1 KEGG: sao:SAOUHSC_01505 hypothetical protein YP_005739504.1 phiSLT ORF100b-like protein YP_005739515.1 phiSLT ORF151-like protein YP_005739545.1 Some domain similarity with Plasminogen activator inhibitor-1_like, recombination factor protein RarA YP_005739546.1 Unknown function YP_005739563.1 identified by similarity to EGAD:72831; match to protein family HMM PF00589 YP_005739573.1 identified by similarity to EGAD:14407; match to protein family HMM PF01475 YP_005739579.1 identified by match to protein family HMM TIGR02651 YP_005739581.1 CDS referred to as GraE in S. aureus Mu50 YP_005739633.1 identified by match to protein family HMM PF01475, ferric-uptake regulator YP_005739645.1 Domain similarity with RecO (involved in initiation of recombination or recombinational repair) YP_005739668.1 late competence operon required for DNA binding and uptake YP_005739674.1 involved in late steps of large ribosomal assembly YP_005739680.1 identified by match to protein family HMM PF01123; match to protein family HMM PF02876 YP_005739682.1 Domain similarity with LamB_YcsF, LamB/YcsF family YP_005739694.1 Unknown function YP_005739699.1 identified by match to protein family HMM PF00266, PFAM: aminotransferase class V; Pyridoxal-dependent decarboxylase KEGG: sav:SAV1622 iron-sulfur cofactor synthesis protein homolog YP_005739702.1 Unknown function YP_005739740.1 negative effector of steady-state concentration of glutamyl-tRNA reductase hemA YP_005739772.1 identified by match to protein family HMM PF00571; match to protein family HMM PF03061; match to protein family HMM PF07085 YP_005739778.1 UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general 'stress endurance' activity. YP_005739779.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_005739784.1 aminotransferase class-V protein YP_005739785.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_005739789.1 related to the OsmC family of osmotically/stress induced proteins YP_005739798.1 identified by match to protein family HMM PF04650; match to protein family HMM PF05031; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168 YP_005739804.1 catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate YP_005739822.1 In other S. aureus genomes, this has been termed flavoprotein YP_005739827.1 contains a radical SAM superfamily domain YP_005739843.1 Some domain similarity with ComK, Genetic competence transcription factor YP_005739852.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_005739853.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_005739855.1 Domain similarity with Nudix Hydrolase whose substrates are metabolites or cell signaling molecules YP_005739861.1 low complexity sequence YP_005739875.1 potential pseudogene, N-term truncated as original start codon missing through mutation YP_005739877.1 domain similarity with lipase (class 3) YP_005739881.1 Pathogenicity island SaPIn2 YP_005739882.1 identified by similarity to OMNI:SA1865; match to protein family HMM PF00089 YP_005739887.1 N-term is highly conserved, C-term appears to be in two classes across S.aureus; has previously been lablled as possible beta-lactamase; has potential signal peptide YP_005739899.1 predicted esterase of the alpha/beta hydrolase fold YP_005739900.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX YP_005739901.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_005739902.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_005739906.1 involved in cell-cycle regulation YP_005739915.1 contains CheY-like receiver domain YP_005739923.1 KEGG: sao:SAOUHSC_01987 hypothetical protein YP_005739935.1 conserved hypothetical protein of unknown function YP_005739956.1 Identified by match to protein family HMM PF00557; match to protein family HMM TIGR00500. Catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_005739957.1 Domain similarity to membrane protein of unknown function YP_005739969.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes plac YP_005739975.1 this protein binds to tryptophan and represses transcription of the Trp operon YP_005739978.1 Significant domain similarity with Staphostatin A YP_005739991.1 Some domain similarity with YolD, Glutaryl-CoA dehydrogenase (GCD),KaiA, Mitochondrial 28S ribosomal protein S30 (PDCD9). YP_005740004.1 Domain similarity with Aspartate/tyrosine/aromatic aminotransferase YP_005740005.1 Originally encoded a novel 72-kDa surface protein of S. aureus capable of binding to several extracellular matrix proteins, including fibronectin, fibrinogen, vitronectin, bone sialoprotein, and thrombospondin. May undergo programmed frameshifting. YP_005740007.1 KEGG: sao:SAOUHSC_02164 hypothetical protein YP_005740019.1 Some domain similarity with phage tail protein YP_005740023.1 similarity with Bacterial Ig-like domain YP_005740026.1 Domain similarity with hypothetical phage protein YP_005740027.1 Domain similarity with Bacteriophage head-tail adaptor YP_005740028.1 Domain similarity to phage protein YP_005740067.1 Some Domain similarity with HTH_XRE (Helix-turn-helix XRE-family like proteins) YP_005740071.1 In other S. aureus genomes, this has been termed hypothetical bacteriophage protein YP_005740079.1 GroEL is the larger subunit of the GroEL/GroES cytosolic chaperonin YP_005740080.1 GroES is the smaller subunit of the GroEL/GroES cytosolic chaperonin YP_005740085.1 Delta-lysin is a 26 amino acid, hemolytic peptide toxin secreted by Staphylococcus aureus YP_005740090.1 identified by similarity to EGAD:129878; match to protein family HMM PF00294 YP_005740094.1 Some domain similarity with SirA-like protein YP_005740097.1 Significant domain similarity with ABC transporter ATPase component YP_005740102.1 predicted to have essential role in cell wall biosynthesis YP_005740106.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_005740111.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_005740112.1 Domain similarity with SprT (predicted to have roles in transcription elongation). Contains a conserved HExxH motif, indicating a metalloprotease function. YP_005740113.1 contains an S1 RNA binding domain at C-terminal YP_005740124.1 Some domain similarity with uncharacterized membrane protein YP_005740133.1 identified by match to protein family HMM PF01098, similar to rod shape determining protein RodA FtsW YP_005740141.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_005740149.1 Domain similarity with membrane protein of unknown function YP_005740152.1 produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_005740153.1 produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_005740154.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_005740157.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_005740158.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_005740165.1 Domain similarity with Sua5 (involved in regulation of translation initiation) YP_005740172.1 contains HxlR-like helix-turn-helix N-terminal domain YP_005740177.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis b YP_005740179.1 catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type II pantothenate kinases are not regulated by feedback inhibition by coenzyme A YP_005740199.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6Pusing glutamine as a nitrogen source YP_005740204.1 identified by match to protein family HMM PF07564; match to protein family HMM TIGR01167 YP_005740217.1 contains a nucleoside recognition domain YP_005740227.1 Unknown function YP_005740247.1 contains a HTH domain at N-terminus YP_005740268.1 identified by match to protein family HMM PF00344; match to protein family HMM TIGR00967 YP_005740299.1 this protein is considered a factor influencing the level of methicillin resistance YP_005740301.1 identified by match to protein family HMM PF01047 YP_005740316.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_005740322.1 involved in urea transport, promoting its entry into the cell , which can can be advantageous for bacteria as its hydrolysis by urease generates ammonium which is an efficient source of nitrogen and, through its buffering capacity, can also provide resistance to acidic conditions YP_005740323.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_005740334.1 PRK08581, PRK08581, N-acetylmuramoyl-L-alanine amidase domain YP_005740340.1 Significant match to PRK06753, PRK06753, hypothetical protein of unknown function YP_005740348.1 weak CAAX amino terminal protease family domain YP_005740367.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_005740370.1 identified by match to protein family HMM PF02517, membrane associated protease YP_005740372.1 contains a MOSC domain identified in the molybdenum cofactor sulfurase YP_005740393.1 identified by match to protein family HMM PF02698 YP_005740399.1 Unknown function YP_005740408.1 Some domain similarity with NorB (Nitric oxide reductase large subunit), ATPase-Plipid, CbtA (cobalt transporter subunit) and, MopB_Nitrate-R-NarG-like YP_005740410.1 In other S. aureus genomes, this has been termed transcriptional regulator TetR family protein YP_005740415.1 has been referred to as general stress protein 26 YP_005740418.1 Unknown function YP_005740440.1 contains a weak DSBA-like thioredoxin domain YP_005740454.1 catalyzes the formation of pimeloyl-CoA from pimelate and coenzyme A YP_005740459.1 Domain similarity with GtrA (integral membrane protein involved in the synthesis of cell surface polysaccharides). YP_005740465.1 Domain similarity with Icc (phosphohydrolases), SbcD (DNA repair exonuclease) and, Calcineurin-like phosphoesterase YP_005740469.1 drug resistance-involved membrane protein YP_005740471.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_005740515.1 may be bifunctional as phosphoglucomutase YP_005740546.1 catalyzes the formation of pyruvate from lactate YP_005740554.1 some similarity to phosphotransferase system, fructose-specific IIC component YP_005740562.1 identified by match to protein family HMM PF04172. The two products of the lrgAB operon are potential membrane proteins, and LrgA and LrgB are both thought to control of murein hydrolase activity and penicillin tolerance. YP_005740576.1 catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate YP_005740591.1 similar to regulatory protein (pfoS/R) YP_005740623.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_005740629.1 possibly involved in biosynthesis of extracellular polysaccharides YP_005740638.1 catlayzes the formation of siroheme from precorrin-2 YP_005740647.1 contains a MarR-family domain YP_005740649.1 fibrinogen and keratin-10 binding surface anchored protein YP_005740658.1 Domain similarity with membrane protein of unknown function YP_005740673.1 In other S. aureus genomes, this has been termed LPXTG cell wall surface anchor family protein YP_005740679.1 This stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; a fusion protein of this enzyme with MsrB provides protection against oxidative stress in Neisseria gonorrhoeae YP_005740682.1 CobQ/CobB/MinD/ParA nucleotide binding domain YP_005740685.1 predicted N-glycosyltransferase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide YP_005740688.1 involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation-like protein YP_005740700.1 may allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_005740701.1 Some domain similarity with Polysaccharide deacetylase, YbaN protein family, xylanase/chitin deacetylase. YP_005740702.1 N-term is 9aa shorter than its orthologs, potential pseudogene YP_005740720.1 follows the vraDE vancomycin resistance locus YP_005740723.1 Unknown function YP_005740724.1 Small amount of domain similarity with LepA (GTP-binding protein localized in the cytoplasmic membrane). YP_005740734.1 ortholog in pSAS plasmid from Staphylococcus aureus subsp. aureus MSSA476 YP_005740738.1 PFAM: Penicillinase repressor KEGG: sau:SAP012 penicillinase repressor YP_005740740.1 PFAM: beta-lactamase KEGG: sau:SAP010 beta-lactamase YP_005740742.1 similar to lactococcin 972