-- dump date 20140620_073959 -- class Genbank::misc_feature -- table misc_feature_note -- id note 869816000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 869816000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 869816000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816000004 Walker A motif; other site 869816000005 ATP binding site [chemical binding]; other site 869816000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869816000007 Walker B motif; other site 869816000008 arginine finger; other site 869816000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 869816000010 DnaA box-binding interface [nucleotide binding]; other site 869816000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 869816000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 869816000013 putative DNA binding surface [nucleotide binding]; other site 869816000014 dimer interface [polypeptide binding]; other site 869816000015 beta-clamp/clamp loader binding surface; other site 869816000016 beta-clamp/translesion DNA polymerase binding surface; other site 869816000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 869816000018 recF protein; Region: recf; TIGR00611 869816000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 869816000020 Walker A/P-loop; other site 869816000021 ATP binding site [chemical binding]; other site 869816000022 Q-loop/lid; other site 869816000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816000024 ABC transporter signature motif; other site 869816000025 Walker B; other site 869816000026 D-loop; other site 869816000027 H-loop/switch region; other site 869816000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 869816000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816000030 Mg2+ binding site [ion binding]; other site 869816000031 G-X-G motif; other site 869816000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869816000033 anchoring element; other site 869816000034 dimer interface [polypeptide binding]; other site 869816000035 ATP binding site [chemical binding]; other site 869816000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869816000037 active site 869816000038 putative metal-binding site [ion binding]; other site 869816000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869816000040 DNA gyrase subunit A; Validated; Region: PRK05560 869816000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869816000042 CAP-like domain; other site 869816000043 active site 869816000044 primary dimer interface [polypeptide binding]; other site 869816000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869816000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869816000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869816000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869816000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869816000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869816000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 869816000052 putative substrate binding site [chemical binding]; other site 869816000053 putative ATP binding site [chemical binding]; other site 869816000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 869816000055 active sites [active] 869816000056 tetramer interface [polypeptide binding]; other site 869816000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 869816000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 869816000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 869816000060 dimer interface [polypeptide binding]; other site 869816000061 active site 869816000062 motif 1; other site 869816000063 motif 2; other site 869816000064 motif 3; other site 869816000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 869816000066 Predicted membrane protein [Function unknown]; Region: COG4392 869816000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 869816000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 869816000069 Predicted membrane protein [Function unknown]; Region: COG4241 869816000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 869816000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 869816000072 DHH family; Region: DHH; pfam01368 869816000073 DHHA1 domain; Region: DHHA1; pfam02272 869816000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 869816000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 869816000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 869816000077 replicative DNA helicase; Region: DnaB; TIGR00665 869816000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 869816000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 869816000080 Walker A motif; other site 869816000081 ATP binding site [chemical binding]; other site 869816000082 Walker B motif; other site 869816000083 DNA binding loops [nucleotide binding] 869816000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 869816000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 869816000086 GDP-binding site [chemical binding]; other site 869816000087 ACT binding site; other site 869816000088 IMP binding site; other site 869816000089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869816000090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816000091 active site 869816000092 phosphorylation site [posttranslational modification] 869816000093 intermolecular recognition site; other site 869816000094 dimerization interface [polypeptide binding]; other site 869816000095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869816000096 DNA binding site [nucleotide binding] 869816000097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 869816000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869816000099 dimerization interface [polypeptide binding]; other site 869816000100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869816000101 putative active site [active] 869816000102 heme pocket [chemical binding]; other site 869816000103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869816000104 dimer interface [polypeptide binding]; other site 869816000105 phosphorylation site [posttranslational modification] 869816000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816000107 ATP binding site [chemical binding]; other site 869816000108 Mg2+ binding site [ion binding]; other site 869816000109 G-X-G motif; other site 869816000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 869816000111 YycH protein; Region: YycH; pfam07435 869816000112 YycH protein; Region: YycI; cl02015 869816000113 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 869816000114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 869816000115 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 869816000116 putative active site [active] 869816000117 putative metal binding site [ion binding]; other site 869816000118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 869816000119 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 869816000120 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 869816000121 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 869816000122 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 869816000123 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 869816000124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 869816000125 Integrase core domain; Region: rve; pfam00665 869816000126 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 869816000127 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 869816000128 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 869816000129 putative active site [active] 869816000130 catalytic site [active] 869816000131 putative metal binding site [ion binding]; other site 869816000132 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 869816000133 putative active site [active] 869816000134 putative catalytic site [active] 869816000135 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 869816000136 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869816000137 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869816000138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869816000139 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 869816000140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869816000141 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816000142 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869816000143 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 869816000144 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 869816000145 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 869816000146 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 869816000147 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 869816000148 catalytic residues [active] 869816000149 catalytic nucleophile [active] 869816000150 Presynaptic Site I dimer interface [polypeptide binding]; other site 869816000151 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 869816000152 Synaptic Flat tetramer interface [polypeptide binding]; other site 869816000153 Synaptic Site I dimer interface [polypeptide binding]; other site 869816000154 DNA binding site [nucleotide binding] 869816000155 Recombinase; Region: Recombinase; pfam07508 869816000156 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 869816000157 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 869816000158 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 869816000159 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 869816000160 catalytic residues [active] 869816000161 catalytic nucleophile [active] 869816000162 Recombinase; Region: Recombinase; pfam07508 869816000163 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 869816000164 Domain of unknown function (DUF927); Region: DUF927; pfam06048 869816000165 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 869816000166 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 869816000167 Divergent AAA domain; Region: AAA_4; pfam04326 869816000168 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 869816000169 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869816000170 active site residue [active] 869816000171 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 869816000172 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869816000173 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 869816000174 active site 869816000175 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 869816000176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816000177 AAA domain; Region: AAA_21; pfam13304 869816000178 Walker A/P-loop; other site 869816000179 ATP binding site [chemical binding]; other site 869816000180 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869816000181 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 869816000182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816000183 S-adenosylmethionine binding site [chemical binding]; other site 869816000184 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869816000185 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869816000186 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869816000187 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 869816000188 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 869816000189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816000190 ATP binding site [chemical binding]; other site 869816000191 putative Mg++ binding site [ion binding]; other site 869816000192 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 869816000193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 869816000194 active site 869816000195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816000196 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816000197 putative substrate translocation pore; other site 869816000198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869816000199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869816000200 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 869816000201 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816000202 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 869816000203 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869816000204 FMN binding site [chemical binding]; other site 869816000205 active site 869816000206 catalytic residues [active] 869816000207 substrate binding site [chemical binding]; other site 869816000208 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 869816000209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816000210 H+ Antiporter protein; Region: 2A0121; TIGR00900 869816000211 putative substrate translocation pore; other site 869816000212 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 869816000213 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 869816000214 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869816000215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869816000216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869816000217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869816000218 dimerization interface [polypeptide binding]; other site 869816000219 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 869816000220 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 869816000221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869816000222 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869816000223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816000224 S-adenosylmethionine binding site [chemical binding]; other site 869816000225 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 869816000226 active site 869816000227 catalytic site [active] 869816000228 putative metal binding site [ion binding]; other site 869816000229 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816000230 Esterase/lipase [General function prediction only]; Region: COG1647 869816000231 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 869816000232 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 869816000233 metal binding site [ion binding]; metal-binding site 869816000234 dimer interface [polypeptide binding]; other site 869816000235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816000236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816000237 putative substrate translocation pore; other site 869816000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816000239 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 869816000240 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 869816000241 putative NAD(P) binding site [chemical binding]; other site 869816000242 putative active site [active] 869816000243 TspO/MBR family; Region: TspO_MBR; pfam03073 869816000244 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 869816000245 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869816000246 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869816000247 PhoU domain; Region: PhoU; pfam01895 869816000248 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 869816000249 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 869816000250 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 869816000251 L-lactate permease; Region: Lactate_perm; cl00701 869816000252 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816000253 B domain; Region: B; pfam02216 869816000254 B domain; Region: B; pfam02216 869816000255 B domain; Region: B; pfam02216 869816000256 B domain; Region: B; pfam02216 869816000257 B domain; Region: B; pfam02216 869816000258 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869816000259 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816000260 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869816000261 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816000262 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869816000263 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869816000264 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816000265 ABC-ATPase subunit interface; other site 869816000266 dimer interface [polypeptide binding]; other site 869816000267 putative PBP binding regions; other site 869816000268 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869816000269 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816000270 ABC-ATPase subunit interface; other site 869816000271 dimer interface [polypeptide binding]; other site 869816000272 putative PBP binding regions; other site 869816000273 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 869816000274 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 869816000275 siderophore binding site; other site 869816000276 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 869816000277 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869816000278 dimer interface [polypeptide binding]; other site 869816000279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816000280 catalytic residue [active] 869816000281 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 869816000282 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 869816000283 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 869816000284 IucA / IucC family; Region: IucA_IucC; pfam04183 869816000285 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 869816000286 drug efflux system protein MdtG; Provisional; Region: PRK09874 869816000287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816000288 putative substrate translocation pore; other site 869816000289 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 869816000290 IucA / IucC family; Region: IucA_IucC; pfam04183 869816000291 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 869816000292 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 869816000293 IucA / IucC family; Region: IucA_IucC; pfam04183 869816000294 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 869816000295 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 869816000296 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 869816000297 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 869816000298 dimer interface [polypeptide binding]; other site 869816000299 active site 869816000300 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869816000301 catalytic residues [active] 869816000302 substrate binding site [chemical binding]; other site 869816000303 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 869816000304 ParB-like nuclease domain; Region: ParBc; pfam02195 869816000305 acetoin reductase; Validated; Region: PRK08643 869816000306 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 869816000307 NAD binding site [chemical binding]; other site 869816000308 homotetramer interface [polypeptide binding]; other site 869816000309 homodimer interface [polypeptide binding]; other site 869816000310 active site 869816000311 substrate binding site [chemical binding]; other site 869816000312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869816000313 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 869816000314 NAD(P) binding site [chemical binding]; other site 869816000315 active site 869816000316 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 869816000317 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 869816000318 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869816000319 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 869816000320 putative ADP-binding pocket [chemical binding]; other site 869816000321 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869816000322 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 869816000323 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 869816000324 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 869816000325 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 869816000326 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869816000327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869816000328 DNA-binding site [nucleotide binding]; DNA binding site 869816000329 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 869816000330 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 869816000331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816000332 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 869816000333 intersubunit interface [polypeptide binding]; other site 869816000334 active site 869816000335 catalytic residue [active] 869816000336 phosphopentomutase; Provisional; Region: PRK05362 869816000337 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 869816000338 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 869816000339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816000340 dimer interface [polypeptide binding]; other site 869816000341 conserved gate region; other site 869816000342 putative PBP binding loops; other site 869816000343 ABC-ATPase subunit interface; other site 869816000344 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 869816000345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816000346 dimer interface [polypeptide binding]; other site 869816000347 conserved gate region; other site 869816000348 ABC-ATPase subunit interface; other site 869816000349 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 869816000350 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 869816000351 Walker A/P-loop; other site 869816000352 ATP binding site [chemical binding]; other site 869816000353 Q-loop/lid; other site 869816000354 ABC transporter signature motif; other site 869816000355 Walker B; other site 869816000356 D-loop; other site 869816000357 H-loop/switch region; other site 869816000358 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 869816000359 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 869816000360 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 869816000361 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 869816000362 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 869816000363 active site 869816000364 metal binding site [ion binding]; metal-binding site 869816000365 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 869816000366 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869816000367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816000368 non-specific DNA binding site [nucleotide binding]; other site 869816000369 salt bridge; other site 869816000370 sequence-specific DNA binding site [nucleotide binding]; other site 869816000371 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 869816000372 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 869816000373 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 869816000374 putative catalytic cysteine [active] 869816000375 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 869816000376 putative active site [active] 869816000377 metal binding site [ion binding]; metal-binding site 869816000378 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 869816000379 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 869816000380 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 869816000381 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869816000382 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 869816000383 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 869816000384 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 869816000385 NAD(P) binding site [chemical binding]; other site 869816000386 homodimer interface [polypeptide binding]; other site 869816000387 substrate binding site [chemical binding]; other site 869816000388 active site 869816000389 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 869816000390 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 869816000391 NAD(P) binding site [chemical binding]; other site 869816000392 homodimer interface [polypeptide binding]; other site 869816000393 substrate binding site [chemical binding]; other site 869816000394 active site 869816000395 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 869816000396 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 869816000397 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 869816000398 putative NAD(P) binding site [chemical binding]; other site 869816000399 active site 869816000400 putative substrate binding site [chemical binding]; other site 869816000401 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 869816000402 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 869816000403 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 869816000404 active site 869816000405 homodimer interface [polypeptide binding]; other site 869816000406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869816000407 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869816000408 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 869816000409 trimer interface [polypeptide binding]; other site 869816000410 active site 869816000411 substrate binding site [chemical binding]; other site 869816000412 CoA binding site [chemical binding]; other site 869816000413 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 869816000414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869816000415 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 869816000416 Bacterial sugar transferase; Region: Bac_transf; pfam02397 869816000417 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 869816000418 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 869816000419 putative NAD(P) binding site [chemical binding]; other site 869816000420 active site 869816000421 putative substrate binding site [chemical binding]; other site 869816000422 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 869816000423 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 869816000424 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 869816000425 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 869816000426 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 869816000427 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 869816000428 active site 869816000429 homodimer interface [polypeptide binding]; other site 869816000430 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 869816000431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 869816000432 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 869816000433 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 869816000434 NAD(P) binding site [chemical binding]; other site 869816000435 catalytic residues [active] 869816000436 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 869816000437 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 869816000438 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 869816000439 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 869816000440 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 869816000441 Walker A/P-loop; other site 869816000442 ATP binding site [chemical binding]; other site 869816000443 Q-loop/lid; other site 869816000444 ABC transporter signature motif; other site 869816000445 Walker B; other site 869816000446 D-loop; other site 869816000447 H-loop/switch region; other site 869816000448 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 869816000449 NMT1-like family; Region: NMT1_2; pfam13379 869816000450 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 869816000451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869816000452 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 869816000453 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 869816000454 putative transporter; Provisional; Region: PRK10054 869816000455 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 869816000456 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 869816000457 acyl-activating enzyme (AAE) consensus motif; other site 869816000458 AMP binding site [chemical binding]; other site 869816000459 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869816000460 Condensation domain; Region: Condensation; pfam00668 869816000461 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 869816000462 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 869816000463 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 869816000464 acyl-activating enzyme (AAE) consensus motif; other site 869816000465 AMP binding site [chemical binding]; other site 869816000466 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869816000467 thioester reductase domain; Region: Thioester-redct; TIGR01746 869816000468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869816000469 NAD(P) binding site [chemical binding]; other site 869816000470 active site 869816000471 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 869816000472 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 869816000473 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 869816000474 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 869816000475 nucleotide binding site [chemical binding]; other site 869816000476 N-acetyl-L-glutamate binding site [chemical binding]; other site 869816000477 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 869816000478 heterotetramer interface [polypeptide binding]; other site 869816000479 active site pocket [active] 869816000480 cleavage site 869816000481 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 869816000482 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869816000483 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 869816000484 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869816000485 inhibitor-cofactor binding pocket; inhibition site 869816000486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816000487 catalytic residue [active] 869816000488 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 869816000489 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 869816000490 Isochorismatase family; Region: Isochorismatase; pfam00857 869816000491 catalytic triad [active] 869816000492 conserved cis-peptide bond; other site 869816000493 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 869816000494 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 869816000495 dimer interface [polypeptide binding]; other site 869816000496 PYR/PP interface [polypeptide binding]; other site 869816000497 TPP binding site [chemical binding]; other site 869816000498 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869816000499 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 869816000500 TPP-binding site [chemical binding]; other site 869816000501 dimer interface [polypeptide binding]; other site 869816000502 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869816000503 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 869816000504 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869816000505 active site turn [active] 869816000506 phosphorylation site [posttranslational modification] 869816000507 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869816000508 HPr interaction site; other site 869816000509 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869816000510 active site 869816000511 phosphorylation site [posttranslational modification] 869816000512 Uncharacterized conserved protein [Function unknown]; Region: COG3589 869816000513 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 869816000514 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 869816000515 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 869816000516 putative active site [active] 869816000517 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 869816000518 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869816000519 active site turn [active] 869816000520 phosphorylation site [posttranslational modification] 869816000521 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869816000522 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869816000523 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869816000524 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869816000525 putative active site [active] 869816000526 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 869816000527 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 869816000528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816000529 ATP binding site [chemical binding]; other site 869816000530 putative Mg++ binding site [ion binding]; other site 869816000531 RES domain; Region: RES; pfam08808 869816000532 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 869816000533 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869816000534 Walker A/P-loop; other site 869816000535 ATP binding site [chemical binding]; other site 869816000536 Q-loop/lid; other site 869816000537 ABC transporter signature motif; other site 869816000538 Walker B; other site 869816000539 D-loop; other site 869816000540 H-loop/switch region; other site 869816000541 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 869816000542 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869816000543 Walker A/P-loop; other site 869816000544 ATP binding site [chemical binding]; other site 869816000545 Q-loop/lid; other site 869816000546 ABC transporter signature motif; other site 869816000547 Walker B; other site 869816000548 D-loop; other site 869816000549 H-loop/switch region; other site 869816000550 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869816000551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816000552 dimer interface [polypeptide binding]; other site 869816000553 conserved gate region; other site 869816000554 putative PBP binding loops; other site 869816000555 ABC-ATPase subunit interface; other site 869816000556 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 869816000557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816000558 dimer interface [polypeptide binding]; other site 869816000559 conserved gate region; other site 869816000560 ABC-ATPase subunit interface; other site 869816000561 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869816000562 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869816000563 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 869816000564 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 869816000565 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 869816000566 Protein of unknown function, DUF576; Region: DUF576; cl04553 869816000567 azoreductase; Reviewed; Region: PRK00170 869816000568 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869816000569 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869816000570 Peptidase family M23; Region: Peptidase_M23; pfam01551 869816000571 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 869816000572 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 869816000573 Walker A/P-loop; other site 869816000574 ATP binding site [chemical binding]; other site 869816000575 Q-loop/lid; other site 869816000576 ABC transporter signature motif; other site 869816000577 Walker B; other site 869816000578 D-loop; other site 869816000579 H-loop/switch region; other site 869816000580 TOBE domain; Region: TOBE; pfam03459 869816000581 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 869816000582 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869816000583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816000584 dimer interface [polypeptide binding]; other site 869816000585 conserved gate region; other site 869816000586 ABC-ATPase subunit interface; other site 869816000587 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869816000588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816000589 dimer interface [polypeptide binding]; other site 869816000590 conserved gate region; other site 869816000591 putative PBP binding loops; other site 869816000592 ABC-ATPase subunit interface; other site 869816000593 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869816000594 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869816000595 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869816000596 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869816000597 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869816000598 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869816000599 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 869816000600 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 869816000601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 869816000602 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 869816000603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816000604 putative substrate translocation pore; other site 869816000605 Response regulator receiver domain; Region: Response_reg; pfam00072 869816000606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816000607 active site 869816000608 phosphorylation site [posttranslational modification] 869816000609 intermolecular recognition site; other site 869816000610 dimerization interface [polypeptide binding]; other site 869816000611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869816000612 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869816000613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869816000614 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869816000615 Histidine kinase; Region: His_kinase; pfam06580 869816000616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816000617 ATP binding site [chemical binding]; other site 869816000618 Mg2+ binding site [ion binding]; other site 869816000619 G-X-G motif; other site 869816000620 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 869816000621 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 869816000622 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 869816000623 Pyruvate formate lyase 1; Region: PFL1; cd01678 869816000624 coenzyme A binding site [chemical binding]; other site 869816000625 active site 869816000626 catalytic residues [active] 869816000627 glycine loop; other site 869816000628 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 869816000629 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869816000630 FeS/SAM binding site; other site 869816000631 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 869816000632 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 869816000633 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 869816000634 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 869816000635 putative active site [active] 869816000636 catalytic site [active] 869816000637 putative metal binding site [ion binding]; other site 869816000638 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 869816000639 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 869816000640 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 869816000641 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 869816000642 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 869816000643 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 869816000644 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 869816000645 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 869816000646 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 869816000647 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 869816000648 dimer interface [polypeptide binding]; other site 869816000649 active site 869816000650 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 869816000651 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 869816000652 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 869816000653 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869816000654 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 869816000655 substrate binding site [chemical binding]; other site 869816000656 oxyanion hole (OAH) forming residues; other site 869816000657 trimer interface [polypeptide binding]; other site 869816000658 acyl-coenzyme A oxidase; Region: PLN02526 869816000659 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 869816000660 active site 869816000661 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 869816000662 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 869816000663 acyl-activating enzyme (AAE) consensus motif; other site 869816000664 AMP binding site [chemical binding]; other site 869816000665 active site 869816000666 CoA binding site [chemical binding]; other site 869816000667 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 869816000668 Coenzyme A transferase; Region: CoA_trans; smart00882 869816000669 Coenzyme A transferase; Region: CoA_trans; cl17247 869816000670 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 869816000671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869816000672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869816000673 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 869816000674 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 869816000675 NADH(P)-binding; Region: NAD_binding_10; pfam13460 869816000676 putative NAD(P) binding site [chemical binding]; other site 869816000677 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 869816000678 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 869816000679 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 869816000680 Uncharacterized conserved protein [Function unknown]; Region: COG3189 869816000681 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 869816000682 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 869816000683 heme-binding site [chemical binding]; other site 869816000684 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 869816000685 FAD binding pocket [chemical binding]; other site 869816000686 FAD binding motif [chemical binding]; other site 869816000687 phosphate binding motif [ion binding]; other site 869816000688 beta-alpha-beta structure motif; other site 869816000689 NAD binding pocket [chemical binding]; other site 869816000690 Heme binding pocket [chemical binding]; other site 869816000691 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 869816000692 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 869816000693 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869816000694 NAD binding site [chemical binding]; other site 869816000695 dimer interface [polypeptide binding]; other site 869816000696 substrate binding site [chemical binding]; other site 869816000697 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 869816000698 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869816000699 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869816000700 active site turn [active] 869816000701 phosphorylation site [posttranslational modification] 869816000702 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 869816000703 active site 869816000704 tetramer interface [polypeptide binding]; other site 869816000705 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869816000706 Mga helix-turn-helix domain; Region: Mga; pfam05043 869816000707 PRD domain; Region: PRD; pfam00874 869816000708 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869816000709 active site 869816000710 P-loop; other site 869816000711 phosphorylation site [posttranslational modification] 869816000712 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869816000713 active site 869816000714 phosphorylation site [posttranslational modification] 869816000715 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869816000716 active site 869816000717 phosphorylation site [posttranslational modification] 869816000718 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 869816000719 active site 869816000720 P-loop; other site 869816000721 phosphorylation site [posttranslational modification] 869816000722 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 869816000723 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 869816000724 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869816000725 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 869816000726 putative NAD(P) binding site [chemical binding]; other site 869816000727 catalytic Zn binding site [ion binding]; other site 869816000728 structural Zn binding site [ion binding]; other site 869816000729 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869816000730 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 869816000731 putative NAD(P) binding site [chemical binding]; other site 869816000732 catalytic Zn binding site [ion binding]; other site 869816000733 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 869816000734 substrate binding site; other site 869816000735 dimer interface; other site 869816000736 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 869816000737 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869816000738 putative NAD(P) binding site [chemical binding]; other site 869816000739 putative catalytic Zn binding site [ion binding]; other site 869816000740 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 869816000741 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 869816000742 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 869816000743 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 869816000744 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 869816000745 substrate binding site; other site 869816000746 dimer interface; other site 869816000747 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 869816000748 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869816000749 putative NAD(P) binding site [chemical binding]; other site 869816000750 putative catalytic Zn binding site [ion binding]; other site 869816000751 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 869816000752 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 869816000753 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869816000754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869816000755 active site 869816000756 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 869816000757 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 869816000758 Hemerythrin-like domain; Region: Hr-like; cd12108 869816000759 Fe binding site [ion binding]; other site 869816000760 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 869816000761 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 869816000762 Histidine kinase; Region: His_kinase; pfam06580 869816000763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816000764 Mg2+ binding site [ion binding]; other site 869816000765 G-X-G motif; other site 869816000766 two-component response regulator; Provisional; Region: PRK14084 869816000767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816000768 active site 869816000769 phosphorylation site [posttranslational modification] 869816000770 intermolecular recognition site; other site 869816000771 dimerization interface [polypeptide binding]; other site 869816000772 LytTr DNA-binding domain; Region: LytTR; pfam04397 869816000773 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 869816000774 antiholin-like protein LrgB; Provisional; Region: PRK04288 869816000775 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 869816000776 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 869816000777 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869816000778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869816000779 DNA-binding site [nucleotide binding]; DNA binding site 869816000780 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 869816000781 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 869816000782 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 869816000783 HPr interaction site; other site 869816000784 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869816000785 active site 869816000786 phosphorylation site [posttranslational modification] 869816000787 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 869816000788 beta-galactosidase; Region: BGL; TIGR03356 869816000789 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869816000790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816000791 S-adenosylmethionine binding site [chemical binding]; other site 869816000792 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869816000793 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 869816000794 substrate binding site [chemical binding]; other site 869816000795 dimer interface [polypeptide binding]; other site 869816000796 ATP binding site [chemical binding]; other site 869816000797 D-ribose pyranase; Provisional; Region: PRK11797 869816000798 Sugar transport protein; Region: Sugar_transport; pfam06800 869816000799 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869816000800 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869816000801 DNA binding site [nucleotide binding] 869816000802 domain linker motif; other site 869816000803 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 869816000804 dimerization interface [polypeptide binding]; other site 869816000805 ligand binding site [chemical binding]; other site 869816000806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816000807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816000808 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 869816000809 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 869816000810 active site 869816000811 Surface antigen [General function prediction only]; Region: COG3942 869816000812 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869816000813 Peptidase family M23; Region: Peptidase_M23; pfam01551 869816000814 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869816000815 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869816000816 Walker A/P-loop; other site 869816000817 ATP binding site [chemical binding]; other site 869816000818 Q-loop/lid; other site 869816000819 ABC transporter signature motif; other site 869816000820 Walker B; other site 869816000821 D-loop; other site 869816000822 H-loop/switch region; other site 869816000823 Surface antigen [General function prediction only]; Region: COG3942 869816000824 CHAP domain; Region: CHAP; pfam05257 869816000825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 869816000826 Predicted membrane protein [Function unknown]; Region: COG1511 869816000827 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 869816000828 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 869816000829 heterodimer interface [polypeptide binding]; other site 869816000830 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 869816000831 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 869816000832 Uncharacterized small protein [Function unknown]; Region: COG5417 869816000833 Predicted membrane protein [Function unknown]; Region: COG4499 869816000834 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 869816000835 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 869816000836 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 869816000837 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869816000838 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869816000839 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 869816000840 Uncharacterized conserved protein [Function unknown]; Region: COG5444 869816000841 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 869816000842 Protein of unknown function, DUF600; Region: DUF600; cl04640 869816000843 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 869816000844 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 869816000845 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 869816000846 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 869816000847 metal-dependent hydrolase; Provisional; Region: PRK13291 869816000848 DinB superfamily; Region: DinB_2; pfam12867 869816000849 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 869816000850 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869816000851 FtsX-like permease family; Region: FtsX; pfam02687 869816000852 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869816000853 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869816000854 Walker A/P-loop; other site 869816000855 ATP binding site [chemical binding]; other site 869816000856 Q-loop/lid; other site 869816000857 ABC transporter signature motif; other site 869816000858 Walker B; other site 869816000859 D-loop; other site 869816000860 H-loop/switch region; other site 869816000861 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 869816000862 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 869816000863 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 869816000864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816000865 non-specific DNA binding site [nucleotide binding]; other site 869816000866 salt bridge; other site 869816000867 sequence-specific DNA binding site [nucleotide binding]; other site 869816000868 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869816000869 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 869816000870 substrate binding site [chemical binding]; other site 869816000871 ATP binding site [chemical binding]; other site 869816000872 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 869816000873 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 869816000874 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 869816000875 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 869816000876 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 869816000877 putative transporter; Provisional; Region: PRK10484 869816000878 Na binding site [ion binding]; other site 869816000879 N-acetylneuraminate lyase; Provisional; Region: PRK04147 869816000880 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 869816000881 inhibitor site; inhibition site 869816000882 active site 869816000883 dimer interface [polypeptide binding]; other site 869816000884 catalytic residue [active] 869816000885 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869816000886 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869816000887 nucleotide binding site [chemical binding]; other site 869816000888 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 869816000889 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869816000890 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869816000891 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869816000892 putative active site [active] 869816000893 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 869816000894 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 869816000895 putative active site cavity [active] 869816000896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 869816000897 Nucleoside recognition; Region: Gate; pfam07670 869816000898 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869816000899 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 869816000900 PGAP1-like protein; Region: PGAP1; pfam07819 869816000901 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 869816000902 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 869816000903 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 869816000904 putative active site [active] 869816000905 putative FMN binding site [chemical binding]; other site 869816000906 putative substrate binding site [chemical binding]; other site 869816000907 putative catalytic residue [active] 869816000908 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 869816000909 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 869816000910 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 869816000911 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 869816000912 lipoyl attachment site [posttranslational modification]; other site 869816000913 Replication protein C N-terminal domain; Region: RP-C; pfam03428 869816000914 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 869816000915 putative ADP-ribose binding site [chemical binding]; other site 869816000916 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 869816000917 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 869816000918 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 869816000919 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 869816000920 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 869816000921 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 869816000922 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 869816000923 active site 869816000924 P-loop; other site 869816000925 phosphorylation site [posttranslational modification] 869816000926 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869816000927 active site 869816000928 phosphorylation site [posttranslational modification] 869816000929 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869816000930 HTH domain; Region: HTH_11; pfam08279 869816000931 HTH domain; Region: HTH_11; pfam08279 869816000932 PRD domain; Region: PRD; pfam00874 869816000933 PRD domain; Region: PRD; pfam00874 869816000934 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869816000935 active site 869816000936 P-loop; other site 869816000937 phosphorylation site [posttranslational modification] 869816000938 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869816000939 active site 869816000940 phosphorylation site [posttranslational modification] 869816000941 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869816000942 MarR family; Region: MarR_2; pfam12802 869816000943 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869816000944 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 869816000945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 869816000946 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 869816000947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816000948 putative substrate translocation pore; other site 869816000949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816000950 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 869816000951 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869816000952 Zn binding site [ion binding]; other site 869816000953 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 869816000954 Zn binding site [ion binding]; other site 869816000955 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 869816000956 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 869816000957 Predicted flavoprotein [General function prediction only]; Region: COG0431 869816000958 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869816000959 Predicted membrane protein [Function unknown]; Region: COG2855 869816000960 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869816000961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869816000962 Imelysin; Region: Peptidase_M75; pfam09375 869816000963 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 869816000964 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 869816000965 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 869816000966 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 869816000967 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 869816000968 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 869816000969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816000970 non-specific DNA binding site [nucleotide binding]; other site 869816000971 salt bridge; other site 869816000972 sequence-specific DNA binding site [nucleotide binding]; other site 869816000973 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 869816000974 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869816000975 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869816000976 Walker A/P-loop; other site 869816000977 ATP binding site [chemical binding]; other site 869816000978 Q-loop/lid; other site 869816000979 ABC transporter signature motif; other site 869816000980 Walker B; other site 869816000981 D-loop; other site 869816000982 H-loop/switch region; other site 869816000983 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 869816000984 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 869816000985 putative acyltransferase; Provisional; Region: PRK05790 869816000986 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 869816000987 dimer interface [polypeptide binding]; other site 869816000988 active site 869816000989 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 869816000990 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 869816000991 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 869816000992 THF binding site; other site 869816000993 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 869816000994 substrate binding site [chemical binding]; other site 869816000995 THF binding site; other site 869816000996 zinc-binding site [ion binding]; other site 869816000997 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 869816000998 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 869816000999 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 869816001000 FAD binding site [chemical binding]; other site 869816001001 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 869816001002 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869816001003 homodimer interface [polypeptide binding]; other site 869816001004 substrate-cofactor binding pocket; other site 869816001005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816001006 catalytic residue [active] 869816001007 cystathionine gamma-synthase; Reviewed; Region: PRK08247 869816001008 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869816001009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869816001010 catalytic residue [active] 869816001011 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 869816001012 ParB-like nuclease domain; Region: ParB; smart00470 869816001013 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 869816001014 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869816001015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 869816001016 GTP-binding protein YchF; Reviewed; Region: PRK09601 869816001017 YchF GTPase; Region: YchF; cd01900 869816001018 G1 box; other site 869816001019 GTP/Mg2+ binding site [chemical binding]; other site 869816001020 Switch I region; other site 869816001021 G2 box; other site 869816001022 Switch II region; other site 869816001023 G3 box; other site 869816001024 G4 box; other site 869816001025 G5 box; other site 869816001026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 869816001027 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 869816001028 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869816001029 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869816001030 dimer interface [polypeptide binding]; other site 869816001031 ssDNA binding site [nucleotide binding]; other site 869816001032 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869816001033 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 869816001034 Abi-like protein; Region: Abi_2; pfam07751 869816001035 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869816001036 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 869816001038 Predicted membrane protein [Function unknown]; Region: COG3212 869816001039 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 869816001040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 869816001041 non-specific DNA binding site [nucleotide binding]; other site 869816001042 salt bridge; other site 869816001043 sequence-specific DNA binding site [nucleotide binding]; other site 869816001044 Predicted membrane protein [Function unknown]; Region: COG2261 869816001045 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869816001046 catalytic core [active] 869816001047 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 869816001048 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 869816001049 catalytic residue [active] 869816001050 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 869816001051 catalytic residues [active] 869816001052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869816001053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816001054 peroxiredoxin; Region: AhpC; TIGR03137 869816001055 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 869816001056 dimer interface [polypeptide binding]; other site 869816001057 decamer (pentamer of dimers) interface [polypeptide binding]; other site 869816001058 catalytic triad [active] 869816001059 peroxidatic and resolving cysteines [active] 869816001060 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 869816001061 dimer interface [polypeptide binding]; other site 869816001062 FMN binding site [chemical binding]; other site 869816001063 NADPH bind site [chemical binding]; other site 869816001064 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 869816001065 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 869816001066 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869816001067 active site 869816001068 xanthine permease; Region: pbuX; TIGR03173 869816001069 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 869816001070 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869816001071 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 869816001072 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869816001073 active site 869816001074 GMP synthase; Reviewed; Region: guaA; PRK00074 869816001075 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 869816001076 AMP/PPi binding site [chemical binding]; other site 869816001077 candidate oxyanion hole; other site 869816001078 catalytic triad [active] 869816001079 potential glutamine specificity residues [chemical binding]; other site 869816001080 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 869816001081 ATP Binding subdomain [chemical binding]; other site 869816001082 Ligand Binding sites [chemical binding]; other site 869816001083 Dimerization subdomain; other site 869816001084 PemK-like protein; Region: PemK; pfam02452 869816001085 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 869816001086 Protein of unknown function (DUF523); Region: DUF523; pfam04463 869816001087 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 869816001088 Divergent AAA domain; Region: AAA_4; pfam04326 869816001089 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 869816001090 Predicted membrane protein [Function unknown]; Region: COG3759 869816001091 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 869816001092 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 869816001093 NADP binding site [chemical binding]; other site 869816001094 superantigen-like protein; Reviewed; Region: PRK13037 869816001095 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 869816001096 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001097 superantigen-like protein; Reviewed; Region: PRK13041 869816001098 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 869816001099 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001100 superantigen-like protein; Reviewed; Region: PRK13041 869816001101 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 869816001102 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001103 superantigen-like protein; Reviewed; Region: PRK13042 869816001104 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 869816001105 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001106 superantigen-like protein 5; Reviewed; Region: PRK13035 869816001107 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 869816001108 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001109 superantigen-like protein; Reviewed; Region: PRK13040 869816001110 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 869816001111 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001112 superantigen-like protein 7; Reviewed; Region: PRK13346 869816001113 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 869816001114 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001115 superantigen-like protein; Reviewed; Region: PRK13039 869816001116 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 869816001117 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001118 superantigen-like protein; Reviewed; Region: PRK13038 869816001119 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 869816001120 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001121 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869816001122 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869816001123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816001124 S-adenosylmethionine binding site [chemical binding]; other site 869816001125 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869816001126 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869816001127 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869816001128 superantigen-like protein; Reviewed; Region: PRK13036 869816001129 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 869816001130 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816001131 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816001132 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816001133 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816001134 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816001135 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816001136 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816001137 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816001138 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 869816001139 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 869816001140 nucleophilic elbow; other site 869816001141 catalytic triad; other site 869816001142 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 869816001143 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 869816001144 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 869816001145 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 869816001146 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869816001147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 869816001148 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 869816001149 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 869816001150 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 869816001151 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869816001152 active site 869816001153 Esterase/lipase [General function prediction only]; Region: COG1647 869816001154 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869816001155 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 869816001156 Na2 binding site [ion binding]; other site 869816001157 putative substrate binding site 1 [chemical binding]; other site 869816001158 Na binding site 1 [ion binding]; other site 869816001159 putative substrate binding site 2 [chemical binding]; other site 869816001160 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 869816001161 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869816001162 dimer interface [polypeptide binding]; other site 869816001163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816001164 catalytic residue [active] 869816001165 cystathionine beta-lyase; Provisional; Region: PRK07671 869816001166 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869816001167 homodimer interface [polypeptide binding]; other site 869816001168 substrate-cofactor binding pocket; other site 869816001169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816001170 catalytic residue [active] 869816001171 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 869816001172 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 869816001173 Walker A/P-loop; other site 869816001174 ATP binding site [chemical binding]; other site 869816001175 Q-loop/lid; other site 869816001176 ABC transporter signature motif; other site 869816001177 Walker B; other site 869816001178 D-loop; other site 869816001179 H-loop/switch region; other site 869816001180 NIL domain; Region: NIL; pfam09383 869816001181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816001182 dimer interface [polypeptide binding]; other site 869816001183 conserved gate region; other site 869816001184 ABC-ATPase subunit interface; other site 869816001185 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 869816001186 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 869816001187 LysM domain; Region: LysM; pfam01476 869816001188 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869816001189 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869816001190 Surface antigen [General function prediction only]; Region: COG3942 869816001191 CHAP domain; Region: CHAP; pfam05257 869816001192 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 869816001193 nudix motif; other site 869816001194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816001195 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869816001196 Coenzyme A binding pocket [chemical binding]; other site 869816001197 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 869816001198 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 869816001199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869816001200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869816001201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869816001202 dimerization interface [polypeptide binding]; other site 869816001203 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 869816001204 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 869816001205 active site 869816001206 dimer interface [polypeptide binding]; other site 869816001207 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 869816001208 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 869816001209 active site 869816001210 FMN binding site [chemical binding]; other site 869816001211 substrate binding site [chemical binding]; other site 869816001212 3Fe-4S cluster binding site [ion binding]; other site 869816001213 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 869816001214 domain interface; other site 869816001215 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 869816001216 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869816001217 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 869816001218 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869816001219 active site turn [active] 869816001220 phosphorylation site [posttranslational modification] 869816001221 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869816001222 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869816001223 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869816001224 Ca binding site [ion binding]; other site 869816001225 active site 869816001226 catalytic site [active] 869816001227 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 869816001228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869816001229 DNA-binding site [nucleotide binding]; DNA binding site 869816001230 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 869816001231 UTRA domain; Region: UTRA; pfam07702 869816001232 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869816001233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816001234 Coenzyme A binding pocket [chemical binding]; other site 869816001235 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 869816001236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816001237 Walker A motif; other site 869816001238 ATP binding site [chemical binding]; other site 869816001239 Walker B motif; other site 869816001240 arginine finger; other site 869816001241 hypothetical protein; Validated; Region: PRK00153 869816001242 recombination protein RecR; Reviewed; Region: recR; PRK00076 869816001243 RecR protein; Region: RecR; pfam02132 869816001244 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 869816001245 putative active site [active] 869816001246 putative metal-binding site [ion binding]; other site 869816001247 tetramer interface [polypeptide binding]; other site 869816001248 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 869816001249 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869816001250 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869816001251 catalytic residue [active] 869816001252 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 869816001253 thymidylate kinase; Validated; Region: tmk; PRK00698 869816001254 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 869816001255 TMP-binding site; other site 869816001256 ATP-binding site [chemical binding]; other site 869816001257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 869816001258 DNA polymerase III subunit delta'; Validated; Region: PRK08058 869816001259 DNA polymerase III subunit delta'; Validated; Region: PRK08485 869816001260 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 869816001261 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 869816001262 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 869816001263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816001264 S-adenosylmethionine binding site [chemical binding]; other site 869816001265 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 869816001266 GIY-YIG motif/motif A; other site 869816001267 putative active site [active] 869816001268 putative metal binding site [ion binding]; other site 869816001269 Predicted methyltransferases [General function prediction only]; Region: COG0313 869816001270 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 869816001271 putative SAM binding site [chemical binding]; other site 869816001272 putative homodimer interface [polypeptide binding]; other site 869816001273 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 869816001274 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 869816001275 active site 869816001276 HIGH motif; other site 869816001277 KMSKS motif; other site 869816001278 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 869816001279 tRNA binding surface [nucleotide binding]; other site 869816001280 anticodon binding site; other site 869816001281 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 869816001282 dimer interface [polypeptide binding]; other site 869816001283 putative tRNA-binding site [nucleotide binding]; other site 869816001284 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 869816001285 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869816001286 active site 869816001287 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 869816001288 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 869816001289 putative active site [active] 869816001290 putative metal binding site [ion binding]; other site 869816001291 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 869816001292 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 869816001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816001294 S-adenosylmethionine binding site [chemical binding]; other site 869816001295 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 869816001296 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 869816001297 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869816001298 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869816001299 pur operon repressor; Provisional; Region: PRK09213 869816001300 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 869816001301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869816001302 active site 869816001303 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 869816001304 homotrimer interaction site [polypeptide binding]; other site 869816001305 putative active site [active] 869816001306 regulatory protein SpoVG; Reviewed; Region: PRK13259 869816001307 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 869816001308 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 869816001309 Substrate binding site; other site 869816001310 Mg++ binding site; other site 869816001311 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 869816001312 active site 869816001313 substrate binding site [chemical binding]; other site 869816001314 CoA binding site [chemical binding]; other site 869816001315 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 869816001316 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869816001317 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869816001318 active site 869816001319 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 869816001320 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 869816001321 5S rRNA interface [nucleotide binding]; other site 869816001322 CTC domain interface [polypeptide binding]; other site 869816001323 L16 interface [polypeptide binding]; other site 869816001324 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 869816001325 putative active site [active] 869816001326 catalytic residue [active] 869816001327 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 869816001328 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 869816001329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816001330 ATP binding site [chemical binding]; other site 869816001331 putative Mg++ binding site [ion binding]; other site 869816001332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869816001333 nucleotide binding region [chemical binding]; other site 869816001334 ATP-binding site [chemical binding]; other site 869816001335 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 869816001336 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869816001337 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 869816001338 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 869816001339 putative SAM binding site [chemical binding]; other site 869816001340 putative homodimer interface [polypeptide binding]; other site 869816001341 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 869816001342 homodimer interface [polypeptide binding]; other site 869816001343 metal binding site [ion binding]; metal-binding site 869816001344 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869816001345 RNA binding surface [nucleotide binding]; other site 869816001346 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 869816001347 Septum formation initiator; Region: DivIC; pfam04977 869816001348 hypothetical protein; Provisional; Region: PRK08582 869816001349 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 869816001350 RNA binding site [nucleotide binding]; other site 869816001351 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 869816001352 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 869816001353 Ligand Binding Site [chemical binding]; other site 869816001354 TilS substrate C-terminal domain; Region: TilS_C; smart00977 869816001355 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 869816001356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869816001357 active site 869816001358 FtsH Extracellular; Region: FtsH_ext; pfam06480 869816001359 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 869816001360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816001361 Walker A motif; other site 869816001362 ATP binding site [chemical binding]; other site 869816001363 Walker B motif; other site 869816001364 arginine finger; other site 869816001365 Peptidase family M41; Region: Peptidase_M41; pfam01434 869816001366 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 869816001367 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 869816001368 dimerization interface [polypeptide binding]; other site 869816001369 domain crossover interface; other site 869816001370 redox-dependent activation switch; other site 869816001371 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 869816001372 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869816001373 dimer interface [polypeptide binding]; other site 869816001374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816001375 catalytic residue [active] 869816001376 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 869816001377 dihydropteroate synthase; Region: DHPS; TIGR01496 869816001378 substrate binding pocket [chemical binding]; other site 869816001379 dimer interface [polypeptide binding]; other site 869816001380 inhibitor binding site; inhibition site 869816001381 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 869816001382 homooctamer interface [polypeptide binding]; other site 869816001383 active site 869816001384 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 869816001385 catalytic center binding site [active] 869816001386 ATP binding site [chemical binding]; other site 869816001387 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 869816001388 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 869816001389 dimer interface [polypeptide binding]; other site 869816001390 putative anticodon binding site; other site 869816001391 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 869816001392 motif 1; other site 869816001393 active site 869816001394 motif 2; other site 869816001395 motif 3; other site 869816001396 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 869816001397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869816001398 DNA-binding site [nucleotide binding]; DNA binding site 869816001399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869816001400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816001401 homodimer interface [polypeptide binding]; other site 869816001402 catalytic residue [active] 869816001403 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 869816001404 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 869816001405 active site 869816001406 multimer interface [polypeptide binding]; other site 869816001407 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 869816001408 predicted active site [active] 869816001409 catalytic triad [active] 869816001410 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 869816001411 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 869816001412 Nucleoside recognition; Region: Gate; pfam07670 869816001413 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 869816001414 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 869816001415 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 869816001416 UvrB/uvrC motif; Region: UVR; pfam02151 869816001417 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 869816001418 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 869816001419 ADP binding site [chemical binding]; other site 869816001420 phosphagen binding site; other site 869816001421 substrate specificity loop; other site 869816001422 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869816001423 Clp amino terminal domain; Region: Clp_N; pfam02861 869816001424 Clp amino terminal domain; Region: Clp_N; pfam02861 869816001425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816001426 Walker A motif; other site 869816001427 ATP binding site [chemical binding]; other site 869816001428 Walker B motif; other site 869816001429 arginine finger; other site 869816001430 UvrB/uvrC motif; Region: UVR; pfam02151 869816001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816001432 Walker A motif; other site 869816001433 ATP binding site [chemical binding]; other site 869816001434 Walker B motif; other site 869816001435 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869816001436 DNA repair protein RadA; Provisional; Region: PRK11823 869816001437 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 869816001438 Walker A motif/ATP binding site; other site 869816001439 ATP binding site [chemical binding]; other site 869816001440 Walker B motif; other site 869816001441 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 869816001442 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 869816001443 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 869816001444 putative active site [active] 869816001445 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 869816001446 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869816001447 active site 869816001448 HIGH motif; other site 869816001449 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869816001450 active site 869816001451 KMSKS motif; other site 869816001452 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 869816001453 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 869816001454 trimer interface [polypeptide binding]; other site 869816001455 active site 869816001456 substrate binding site [chemical binding]; other site 869816001457 CoA binding site [chemical binding]; other site 869816001458 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 869816001459 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869816001460 active site 869816001461 HIGH motif; other site 869816001462 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869816001463 KMSKS motif; other site 869816001464 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869816001465 tRNA binding surface [nucleotide binding]; other site 869816001466 anticodon binding site; other site 869816001467 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 869816001468 active site 869816001469 dimerization interface [polypeptide binding]; other site 869816001470 metal binding site [ion binding]; metal-binding site 869816001471 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869816001472 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 869816001473 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869816001474 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 869816001475 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 869816001476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869816001477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 869816001478 DNA binding residues [nucleotide binding] 869816001479 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 869816001480 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 869816001481 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 869816001482 putative homodimer interface [polypeptide binding]; other site 869816001483 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 869816001484 heterodimer interface [polypeptide binding]; other site 869816001485 homodimer interface [polypeptide binding]; other site 869816001486 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 869816001487 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 869816001488 23S rRNA interface [nucleotide binding]; other site 869816001489 L7/L12 interface [polypeptide binding]; other site 869816001490 putative thiostrepton binding site; other site 869816001491 L25 interface [polypeptide binding]; other site 869816001492 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 869816001493 mRNA/rRNA interface [nucleotide binding]; other site 869816001494 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 869816001495 23S rRNA interface [nucleotide binding]; other site 869816001496 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 869816001497 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 869816001498 peripheral dimer interface [polypeptide binding]; other site 869816001499 core dimer interface [polypeptide binding]; other site 869816001500 L10 interface [polypeptide binding]; other site 869816001501 L11 interface [polypeptide binding]; other site 869816001502 putative EF-Tu interaction site [polypeptide binding]; other site 869816001503 putative EF-G interaction site [polypeptide binding]; other site 869816001504 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869816001505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816001506 S-adenosylmethionine binding site [chemical binding]; other site 869816001507 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869816001508 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 869816001509 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 869816001510 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869816001511 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869816001512 RPB10 interaction site [polypeptide binding]; other site 869816001513 RPB1 interaction site [polypeptide binding]; other site 869816001514 RPB11 interaction site [polypeptide binding]; other site 869816001515 RPB3 interaction site [polypeptide binding]; other site 869816001516 RPB12 interaction site [polypeptide binding]; other site 869816001517 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 869816001518 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 869816001519 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 869816001520 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 869816001521 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 869816001522 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869816001523 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 869816001524 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 869816001525 G-loop; other site 869816001526 DNA binding site [nucleotide binding] 869816001527 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 869816001528 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 869816001529 S17 interaction site [polypeptide binding]; other site 869816001530 S8 interaction site; other site 869816001531 16S rRNA interaction site [nucleotide binding]; other site 869816001532 streptomycin interaction site [chemical binding]; other site 869816001533 23S rRNA interaction site [nucleotide binding]; other site 869816001534 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 869816001535 30S ribosomal protein S7; Validated; Region: PRK05302 869816001536 elongation factor G; Reviewed; Region: PRK00007 869816001537 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 869816001538 G1 box; other site 869816001539 putative GEF interaction site [polypeptide binding]; other site 869816001540 GTP/Mg2+ binding site [chemical binding]; other site 869816001541 Switch I region; other site 869816001542 G2 box; other site 869816001543 G3 box; other site 869816001544 Switch II region; other site 869816001545 G4 box; other site 869816001546 G5 box; other site 869816001547 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 869816001548 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 869816001549 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 869816001550 elongation factor Tu; Reviewed; Region: PRK00049 869816001551 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 869816001552 G1 box; other site 869816001553 GEF interaction site [polypeptide binding]; other site 869816001554 GTP/Mg2+ binding site [chemical binding]; other site 869816001555 Switch I region; other site 869816001556 G2 box; other site 869816001557 G3 box; other site 869816001558 Switch II region; other site 869816001559 G4 box; other site 869816001560 G5 box; other site 869816001561 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 869816001562 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 869816001563 Antibiotic Binding Site [chemical binding]; other site 869816001564 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 869816001565 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 869816001566 metal binding site [ion binding]; metal-binding site 869816001567 dimer interface [polypeptide binding]; other site 869816001568 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 869816001569 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 869816001570 substrate-cofactor binding pocket; other site 869816001571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816001572 catalytic residue [active] 869816001573 chaperone protein HchA; Provisional; Region: PRK04155 869816001574 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 869816001575 conserved cys residue [active] 869816001576 ribulokinase; Provisional; Region: PRK04123 869816001577 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 869816001578 N- and C-terminal domain interface [polypeptide binding]; other site 869816001579 active site 869816001580 MgATP binding site [chemical binding]; other site 869816001581 catalytic site [active] 869816001582 metal binding site [ion binding]; metal-binding site 869816001583 carbohydrate binding site [chemical binding]; other site 869816001584 homodimer interface [polypeptide binding]; other site 869816001585 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 869816001586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869816001587 NAD(P) binding site [chemical binding]; other site 869816001588 active site 869816001589 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 869816001590 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 869816001591 homodimer interface [polypeptide binding]; other site 869816001592 substrate-cofactor binding pocket; other site 869816001593 catalytic residue [active] 869816001594 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869816001595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816001596 motif II; other site 869816001597 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 869816001598 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 869816001599 Substrate-binding site [chemical binding]; other site 869816001600 Substrate specificity [chemical binding]; other site 869816001601 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 869816001602 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 869816001603 Substrate-binding site [chemical binding]; other site 869816001604 Substrate specificity [chemical binding]; other site 869816001605 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 869816001606 nucleoside/Zn binding site; other site 869816001607 dimer interface [polypeptide binding]; other site 869816001608 catalytic motif [active] 869816001609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816001610 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869816001611 active site 869816001612 motif I; other site 869816001613 motif II; other site 869816001614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816001615 Predicted flavoprotein [General function prediction only]; Region: COG0431 869816001616 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869816001617 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816001618 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 869816001619 Cna protein B-type domain; Region: Cna_B; pfam05738 869816001620 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 869816001621 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816001622 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 869816001623 Cna protein B-type domain; Region: Cna_B; pfam05738 869816001624 Cna protein B-type domain; Region: Cna_B; pfam05738 869816001625 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 869816001626 Cna protein B-type domain; Region: Cna_B; pfam05738 869816001627 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 869816001628 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816001629 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 869816001630 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 869816001631 Cna protein B-type domain; Region: Cna_B; pfam05738 869816001632 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 869816001633 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 869816001634 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 869816001635 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869816001636 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 869816001637 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 869816001638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869816001639 putative GTP cyclohydrolase; Provisional; Region: PRK13674 869816001640 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 869816001641 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 869816001642 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869816001643 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 869816001644 active site 869816001645 trimer interface [polypeptide binding]; other site 869816001646 allosteric site; other site 869816001647 active site lid [active] 869816001648 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869816001649 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 869816001650 active site 869816001651 dimer interface [polypeptide binding]; other site 869816001652 magnesium binding site [ion binding]; other site 869816001653 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 869816001654 tetramer interface [polypeptide binding]; other site 869816001655 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869816001656 active site 869816001657 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869816001658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816001659 motif II; other site 869816001660 proline/glycine betaine transporter; Provisional; Region: PRK10642 869816001661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816001662 putative substrate translocation pore; other site 869816001663 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 869816001664 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 869816001665 acyl-activating enzyme (AAE) consensus motif; other site 869816001666 AMP binding site [chemical binding]; other site 869816001667 active site 869816001668 CoA binding site [chemical binding]; other site 869816001669 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 869816001670 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 869816001671 dimer interface [polypeptide binding]; other site 869816001672 active site 869816001673 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869816001674 dimer interface [polypeptide binding]; other site 869816001675 substrate binding site [chemical binding]; other site 869816001676 ATP binding site [chemical binding]; other site 869816001677 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 869816001678 ligand binding site [chemical binding]; other site 869816001679 active site 869816001680 UGI interface [polypeptide binding]; other site 869816001681 catalytic site [active] 869816001682 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 869816001683 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 869816001684 Uncharacterized conserved protein [Function unknown]; Region: COG3610 869816001685 Uncharacterized conserved protein [Function unknown]; Region: COG2966 869816001686 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 869816001687 putative heme peroxidase; Provisional; Region: PRK12276 869816001688 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 869816001689 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 869816001690 mevalonate kinase; Region: mevalon_kin; TIGR00549 869816001691 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869816001692 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869816001693 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 869816001694 diphosphomevalonate decarboxylase; Region: PLN02407 869816001695 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 869816001696 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869816001697 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869816001698 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 869816001699 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 869816001700 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 869816001701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816001702 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869816001703 Predicted transcriptional regulator [Transcription]; Region: COG1959 869816001704 Transcriptional regulator; Region: Rrf2; pfam02082 869816001705 LXG domain of WXG superfamily; Region: LXG; pfam04740 869816001706 Protein of unknown function (DUF443); Region: DUF443; pfam04276 869816001707 Protein of unknown function (DUF443); Region: DUF443; pfam04276 869816001708 Protein of unknown function (DUF443); Region: DUF443; pfam04276 869816001709 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 869816001710 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869816001711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 869816001712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816001713 Coenzyme A binding pocket [chemical binding]; other site 869816001714 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 869816001715 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869816001716 Zn2+ binding site [ion binding]; other site 869816001717 Mg2+ binding site [ion binding]; other site 869816001718 YwhD family; Region: YwhD; pfam08741 869816001719 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 869816001720 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 869816001721 NAD binding site [chemical binding]; other site 869816001722 substrate binding site [chemical binding]; other site 869816001723 catalytic Zn binding site [ion binding]; other site 869816001724 tetramer interface [polypeptide binding]; other site 869816001725 structural Zn binding site [ion binding]; other site 869816001726 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 869816001727 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 869816001728 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 869816001729 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 869816001730 active site 869816001731 HIGH motif; other site 869816001732 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869816001733 KMSK motif region; other site 869816001734 tRNA binding surface [nucleotide binding]; other site 869816001735 DALR anticodon binding domain; Region: DALR_1; smart00836 869816001736 anticodon binding site; other site 869816001737 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 869816001738 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869816001739 minor groove reading motif; other site 869816001740 helix-hairpin-helix signature motif; other site 869816001741 substrate binding pocket [chemical binding]; other site 869816001742 active site 869816001743 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 869816001744 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 869816001745 putative binding site residues; other site 869816001746 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 869816001747 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816001748 ABC-ATPase subunit interface; other site 869816001749 dimer interface [polypeptide binding]; other site 869816001750 putative PBP binding regions; other site 869816001751 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 869816001752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816001753 motif II; other site 869816001754 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 869816001755 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869816001756 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 869816001757 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869816001758 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816001759 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869816001760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 869816001761 Protein of unknown function, DUF606; Region: DUF606; pfam04657 869816001762 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 869816001763 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869816001764 active site 869816001765 DNA binding site [nucleotide binding] 869816001766 Int/Topo IB signature motif; other site 869816001767 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 869816001768 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869816001769 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 869816001770 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 869816001771 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 869816001772 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 869816001773 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869816001774 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 869816001775 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 869816001776 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 869816001777 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 869816001778 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 869816001779 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869816001780 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 869816001781 metal binding site [ion binding]; metal-binding site 869816001782 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869816001783 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816001784 ABC-ATPase subunit interface; other site 869816001785 dimer interface [polypeptide binding]; other site 869816001786 putative PBP binding regions; other site 869816001787 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869816001788 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869816001789 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 869816001790 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 869816001791 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 869816001792 FeoA domain; Region: FeoA; pfam04023 869816001793 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 869816001794 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 869816001795 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 869816001796 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 869816001797 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 869816001798 Walker A/P-loop; other site 869816001799 ATP binding site [chemical binding]; other site 869816001800 Q-loop/lid; other site 869816001801 ABC transporter signature motif; other site 869816001802 Walker B; other site 869816001803 D-loop; other site 869816001804 H-loop/switch region; other site 869816001805 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 869816001806 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 869816001807 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869816001808 active site 869816001809 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869816001810 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 869816001811 active site 869816001812 nucleotide binding site [chemical binding]; other site 869816001813 HIGH motif; other site 869816001814 KMSKS motif; other site 869816001815 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 869816001816 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 869816001817 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 869816001818 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869816001819 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869816001820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816001821 Walker A/P-loop; other site 869816001822 ATP binding site [chemical binding]; other site 869816001823 Q-loop/lid; other site 869816001824 ABC transporter signature motif; other site 869816001825 Walker B; other site 869816001826 D-loop; other site 869816001827 H-loop/switch region; other site 869816001828 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 869816001829 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 869816001830 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 869816001831 Uncharacterized conserved protein [Function unknown]; Region: COG1284 869816001832 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869816001833 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 869816001834 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869816001835 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869816001836 Walker A/P-loop; other site 869816001837 ATP binding site [chemical binding]; other site 869816001838 Q-loop/lid; other site 869816001839 ABC transporter signature motif; other site 869816001840 Walker B; other site 869816001841 D-loop; other site 869816001842 H-loop/switch region; other site 869816001843 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869816001844 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816001845 ABC-ATPase subunit interface; other site 869816001846 dimer interface [polypeptide binding]; other site 869816001847 putative PBP binding regions; other site 869816001848 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 869816001849 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816001850 ABC-ATPase subunit interface; other site 869816001851 dimer interface [polypeptide binding]; other site 869816001852 putative PBP binding regions; other site 869816001853 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 869816001854 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 869816001855 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 869816001856 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 869816001857 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 869816001858 Uncharacterized membrane protein [Function unknown]; Region: COG3949 869816001859 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 869816001860 Na binding site [ion binding]; other site 869816001861 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 869816001862 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 869816001863 substrate binding pocket [chemical binding]; other site 869816001864 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 869816001865 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869816001866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816001867 Coenzyme A binding pocket [chemical binding]; other site 869816001868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869816001869 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 869816001870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869816001871 NAD(P) binding site [chemical binding]; other site 869816001872 active site 869816001873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869816001874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816001875 active site 869816001876 phosphorylation site [posttranslational modification] 869816001877 intermolecular recognition site; other site 869816001878 dimerization interface [polypeptide binding]; other site 869816001879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869816001880 DNA binding site [nucleotide binding] 869816001881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869816001882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 869816001883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816001884 ATP binding site [chemical binding]; other site 869816001885 Mg2+ binding site [ion binding]; other site 869816001886 G-X-G motif; other site 869816001887 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869816001888 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869816001889 Walker A/P-loop; other site 869816001890 ATP binding site [chemical binding]; other site 869816001891 Q-loop/lid; other site 869816001892 ABC transporter signature motif; other site 869816001893 Walker B; other site 869816001894 D-loop; other site 869816001895 H-loop/switch region; other site 869816001896 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 869816001897 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 869816001898 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869816001899 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 869816001900 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869816001901 Surface antigen [General function prediction only]; Region: COG3942 869816001902 CHAP domain; Region: CHAP; pfam05257 869816001903 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 869816001904 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 869816001905 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869816001906 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816001907 hypothetical protein; Provisional; Region: PRK12378 869816001908 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 869816001909 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 869816001910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869816001911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869816001912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869816001913 dimerization interface [polypeptide binding]; other site 869816001914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816001915 sugar efflux transporter; Region: 2A0120; TIGR00899 869816001916 putative substrate translocation pore; other site 869816001917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 869816001918 Serine incorporator (Serinc); Region: Serinc; pfam03348 869816001919 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 869816001920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816001921 Coenzyme A binding pocket [chemical binding]; other site 869816001922 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869816001923 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869816001924 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 869816001925 hypothetical protein; Validated; Region: PRK00124 869816001926 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 869816001927 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 869816001928 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 869816001929 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869816001930 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 869816001931 Walker A/P-loop; other site 869816001932 ATP binding site [chemical binding]; other site 869816001933 Q-loop/lid; other site 869816001934 ABC transporter signature motif; other site 869816001935 Walker B; other site 869816001936 D-loop; other site 869816001937 H-loop/switch region; other site 869816001938 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 869816001939 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869816001940 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 869816001941 Walker A/P-loop; other site 869816001942 ATP binding site [chemical binding]; other site 869816001943 Q-loop/lid; other site 869816001944 ABC transporter signature motif; other site 869816001945 Walker B; other site 869816001946 D-loop; other site 869816001947 H-loop/switch region; other site 869816001948 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869816001949 MarR family; Region: MarR; pfam01047 869816001950 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 869816001951 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 869816001952 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 869816001953 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869816001954 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869816001955 active site 869816001956 catalytic tetrad [active] 869816001957 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869816001958 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 869816001959 transmembrane helices; other site 869816001960 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 869816001961 DNA photolyase; Region: DNA_photolyase; pfam00875 869816001962 Predicted membrane protein [Function unknown]; Region: COG4330 869816001963 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 869816001964 trimer interface [polypeptide binding]; other site 869816001965 putative Zn binding site [ion binding]; other site 869816001966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816001967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816001968 putative substrate translocation pore; other site 869816001969 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 869816001970 putative deacylase active site [active] 869816001971 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869816001972 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869816001973 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869816001974 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 869816001975 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869816001976 putative substrate binding site [chemical binding]; other site 869816001977 putative ATP binding site [chemical binding]; other site 869816001978 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 869816001979 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869816001980 active site 869816001981 phosphorylation site [posttranslational modification] 869816001982 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869816001983 active site 869816001984 P-loop; other site 869816001985 phosphorylation site [posttranslational modification] 869816001986 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869816001987 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 869816001988 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 869816001989 active site 869816001990 dimer interface [polypeptide binding]; other site 869816001991 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 869816001992 Domain of unknown function DUF21; Region: DUF21; pfam01595 869816001993 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869816001994 Transporter associated domain; Region: CorC_HlyC; pfam03471 869816001995 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869816001996 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869816001997 active site 869816001998 catalytic tetrad [active] 869816001999 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 869816002000 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 869816002001 Ligand binding site; other site 869816002002 Putative Catalytic site; other site 869816002003 DXD motif; other site 869816002004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869816002005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869816002006 dimer interface [polypeptide binding]; other site 869816002007 phosphorylation site [posttranslational modification] 869816002008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816002009 ATP binding site [chemical binding]; other site 869816002010 Mg2+ binding site [ion binding]; other site 869816002011 G-X-G motif; other site 869816002012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869816002013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816002014 active site 869816002015 phosphorylation site [posttranslational modification] 869816002016 intermolecular recognition site; other site 869816002017 dimerization interface [polypeptide binding]; other site 869816002018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869816002019 DNA binding site [nucleotide binding] 869816002020 DoxX; Region: DoxX; pfam07681 869816002021 Electron transfer DM13; Region: DM13; pfam10517 869816002022 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 869816002023 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 869816002024 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 869816002025 active site 869816002026 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 869816002027 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 869816002028 Ligand Binding Site [chemical binding]; other site 869816002029 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 869816002030 Glutamine amidotransferase class-I; Region: GATase; pfam00117 869816002031 glutamine binding [chemical binding]; other site 869816002032 catalytic triad [active] 869816002033 aminodeoxychorismate synthase; Provisional; Region: PRK07508 869816002034 chorismate binding enzyme; Region: Chorismate_bind; cl10555 869816002035 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869816002036 substrate-cofactor binding pocket; other site 869816002037 Aminotransferase class IV; Region: Aminotran_4; pfam01063 869816002038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816002039 catalytic residue [active] 869816002040 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 869816002041 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 869816002042 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 869816002043 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 869816002044 Sulfatase; Region: Sulfatase; pfam00884 869816002045 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869816002046 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869816002047 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869816002048 ABC transporter; Region: ABC_tran_2; pfam12848 869816002049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869816002050 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 869816002051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816002052 ATP binding site [chemical binding]; other site 869816002053 putative Mg++ binding site [ion binding]; other site 869816002054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869816002055 nucleotide binding region [chemical binding]; other site 869816002056 ATP-binding site [chemical binding]; other site 869816002057 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 869816002058 HRDC domain; Region: HRDC; pfam00570 869816002059 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 869816002060 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 869816002061 Walker A/P-loop; other site 869816002062 ATP binding site [chemical binding]; other site 869816002063 Q-loop/lid; other site 869816002064 ABC transporter signature motif; other site 869816002065 Walker B; other site 869816002066 D-loop; other site 869816002067 H-loop/switch region; other site 869816002068 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 869816002069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816002070 dimer interface [polypeptide binding]; other site 869816002071 conserved gate region; other site 869816002072 ABC-ATPase subunit interface; other site 869816002073 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 869816002074 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 869816002075 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 869816002076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869816002077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816002078 homodimer interface [polypeptide binding]; other site 869816002079 catalytic residue [active] 869816002080 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 869816002081 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 869816002082 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 869816002083 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 869816002084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816002085 putative substrate translocation pore; other site 869816002086 POT family; Region: PTR2; cl17359 869816002087 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 869816002088 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 869816002089 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 869816002090 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 869816002091 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 869816002092 Class I ribonucleotide reductase; Region: RNR_I; cd01679 869816002093 active site 869816002094 dimer interface [polypeptide binding]; other site 869816002095 catalytic residues [active] 869816002096 effector binding site; other site 869816002097 R2 peptide binding site; other site 869816002098 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 869816002099 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 869816002100 dimer interface [polypeptide binding]; other site 869816002101 putative radical transfer pathway; other site 869816002102 diiron center [ion binding]; other site 869816002103 tyrosyl radical; other site 869816002104 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816002105 ABC-ATPase subunit interface; other site 869816002106 dimer interface [polypeptide binding]; other site 869816002107 putative PBP binding regions; other site 869816002108 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816002109 ABC-ATPase subunit interface; other site 869816002110 dimer interface [polypeptide binding]; other site 869816002111 putative PBP binding regions; other site 869816002112 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 869816002113 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869816002114 Walker A/P-loop; other site 869816002115 ATP binding site [chemical binding]; other site 869816002116 Q-loop/lid; other site 869816002117 ABC transporter signature motif; other site 869816002118 Walker B; other site 869816002119 D-loop; other site 869816002120 H-loop/switch region; other site 869816002121 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 869816002122 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 869816002123 putative ligand binding residues [chemical binding]; other site 869816002124 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 869816002125 FAD binding domain; Region: FAD_binding_4; pfam01565 869816002126 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 869816002127 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 869816002128 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 869816002129 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 869816002130 peptidase T; Region: peptidase-T; TIGR01882 869816002131 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 869816002132 metal binding site [ion binding]; metal-binding site 869816002133 dimer interface [polypeptide binding]; other site 869816002134 Uncharacterized conserved protein [Function unknown]; Region: COG3610 869816002135 Uncharacterized conserved protein [Function unknown]; Region: COG2966 869816002136 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 869816002137 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 869816002138 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 869816002139 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869816002140 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869816002141 metal binding site [ion binding]; metal-binding site 869816002142 active site 869816002143 I-site; other site 869816002144 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 869816002145 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 869816002146 Mg++ binding site [ion binding]; other site 869816002147 putative catalytic motif [active] 869816002148 substrate binding site [chemical binding]; other site 869816002149 Uncharacterized conserved protein [Function unknown]; Region: COG1739 869816002150 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 869816002151 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 869816002152 EDD domain protein, DegV family; Region: DegV; TIGR00762 869816002153 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869816002154 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 869816002155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816002156 ATP binding site [chemical binding]; other site 869816002157 putative Mg++ binding site [ion binding]; other site 869816002158 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869816002159 nucleotide binding region [chemical binding]; other site 869816002160 ATP-binding site [chemical binding]; other site 869816002161 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 869816002162 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869816002163 active site 869816002164 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 869816002165 30S subunit binding site; other site 869816002166 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 869816002167 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 869816002168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 869816002169 nucleotide binding region [chemical binding]; other site 869816002170 ATP-binding site [chemical binding]; other site 869816002171 SEC-C motif; Region: SEC-C; pfam02810 869816002172 peptide chain release factor 2; Provisional; Region: PRK06746 869816002173 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869816002174 RF-1 domain; Region: RF-1; pfam00472 869816002175 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 869816002176 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869816002177 Surface antigen [General function prediction only]; Region: COG3942 869816002178 CHAP domain; Region: CHAP; pfam05257 869816002179 HD domain; Region: HD_3; cl17350 869816002180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 869816002181 excinuclease ABC subunit B; Provisional; Region: PRK05298 869816002182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816002183 ATP binding site [chemical binding]; other site 869816002184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869816002185 nucleotide binding region [chemical binding]; other site 869816002186 ATP-binding site [chemical binding]; other site 869816002187 Ultra-violet resistance protein B; Region: UvrB; pfam12344 869816002188 UvrB/uvrC motif; Region: UVR; pfam02151 869816002189 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 869816002190 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869816002191 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869816002192 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 869816002193 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 869816002194 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 869816002195 putative active site [active] 869816002196 putative NTP binding site [chemical binding]; other site 869816002197 putative nucleic acid binding site [nucleotide binding]; other site 869816002198 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 869816002199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 869816002200 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 869816002201 HPr kinase/phosphorylase; Provisional; Region: PRK05428 869816002202 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 869816002203 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 869816002204 Hpr binding site; other site 869816002205 active site 869816002206 homohexamer subunit interaction site [polypeptide binding]; other site 869816002207 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 869816002208 putative acyl transferase; Provisional; Region: PRK10191 869816002209 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 869816002210 putative trimer interface [polypeptide binding]; other site 869816002211 putative CoA binding site [chemical binding]; other site 869816002212 TPR repeat; Region: TPR_11; pfam13414 869816002213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869816002214 binding surface 869816002215 TPR motif; other site 869816002216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869816002217 TPR motif; other site 869816002218 binding surface 869816002219 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 869816002220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869816002221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816002222 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 869816002223 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 869816002224 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 869816002225 phosphate binding site [ion binding]; other site 869816002226 dimer interface [polypeptide binding]; other site 869816002227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 869816002228 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 869816002229 Clp protease; Region: CLP_protease; pfam00574 869816002230 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 869816002231 oligomer interface [polypeptide binding]; other site 869816002232 active site residues [active] 869816002233 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 869816002234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869816002235 NAD(P) binding site [chemical binding]; other site 869816002236 active site 869816002237 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 869816002238 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 869816002239 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 869816002240 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 869816002241 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869816002242 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 869816002243 Phosphoglycerate kinase; Region: PGK; pfam00162 869816002244 substrate binding site [chemical binding]; other site 869816002245 hinge regions; other site 869816002246 ADP binding site [chemical binding]; other site 869816002247 catalytic site [active] 869816002248 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 869816002249 triosephosphate isomerase; Provisional; Region: PRK14565 869816002250 substrate binding site [chemical binding]; other site 869816002251 dimer interface [polypeptide binding]; other site 869816002252 catalytic triad [active] 869816002253 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 869816002254 phosphoglyceromutase; Provisional; Region: PRK05434 869816002255 enolase; Provisional; Region: eno; PRK00077 869816002256 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 869816002257 dimer interface [polypeptide binding]; other site 869816002258 metal binding site [ion binding]; metal-binding site 869816002259 substrate binding pocket [chemical binding]; other site 869816002260 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 869816002261 Esterase/lipase [General function prediction only]; Region: COG1647 869816002262 ribonuclease R; Region: RNase_R; TIGR02063 869816002263 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 869816002264 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 869816002265 RNB domain; Region: RNB; pfam00773 869816002266 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 869816002267 RNA binding site [nucleotide binding]; other site 869816002268 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 869816002269 SmpB-tmRNA interface; other site 869816002270 Integral membrane protein DUF95; Region: DUF95; pfam01944 869816002271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816002272 Coenzyme A binding pocket [chemical binding]; other site 869816002273 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816002274 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 869816002275 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 869816002276 Staphylococcal nuclease homologues; Region: SNc; smart00318 869816002277 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 869816002278 Catalytic site; other site 869816002279 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 869816002280 DNA-binding site [nucleotide binding]; DNA binding site 869816002281 RNA-binding motif; other site 869816002282 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 869816002283 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 869816002284 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869816002285 catalytic core [active] 869816002286 Lysine efflux permease [General function prediction only]; Region: COG1279 869816002287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869816002288 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 869816002289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869816002290 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 869816002291 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 869816002292 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 869816002293 active site 869816002294 catalytic residue [active] 869816002295 dimer interface [polypeptide binding]; other site 869816002296 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 869816002297 putative FMN binding site [chemical binding]; other site 869816002298 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869816002299 catalytic residues [active] 869816002300 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 869816002301 ArsC family; Region: ArsC; pfam03960 869816002302 putative ArsC-like catalytic residues; other site 869816002303 putative TRX-like catalytic residues [active] 869816002304 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 869816002305 lipoyl attachment site [posttranslational modification]; other site 869816002306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 869816002307 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 869816002308 putative active site [active] 869816002309 putative metal binding site [ion binding]; other site 869816002310 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869816002311 catalytic residues [active] 869816002312 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 869816002313 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 869816002314 Walker A/P-loop; other site 869816002315 ATP binding site [chemical binding]; other site 869816002316 Q-loop/lid; other site 869816002317 ABC transporter signature motif; other site 869816002318 Walker B; other site 869816002319 D-loop; other site 869816002320 H-loop/switch region; other site 869816002321 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 869816002322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816002323 dimer interface [polypeptide binding]; other site 869816002324 conserved gate region; other site 869816002325 ABC-ATPase subunit interface; other site 869816002326 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 869816002327 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 869816002328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 869816002329 Predicted membrane protein [Function unknown]; Region: COG2035 869816002330 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 869816002331 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 869816002332 Walker A/P-loop; other site 869816002333 ATP binding site [chemical binding]; other site 869816002334 Q-loop/lid; other site 869816002335 ABC transporter signature motif; other site 869816002336 Walker B; other site 869816002337 D-loop; other site 869816002338 H-loop/switch region; other site 869816002339 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 869816002340 FeS assembly protein SufD; Region: sufD; TIGR01981 869816002341 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 869816002342 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 869816002343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869816002344 catalytic residue [active] 869816002345 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 869816002346 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 869816002347 trimerization site [polypeptide binding]; other site 869816002348 active site 869816002349 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 869816002350 FeS assembly protein SufB; Region: sufB; TIGR01980 869816002351 Domain of unknown function DUF21; Region: DUF21; pfam01595 869816002352 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869816002353 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 869816002354 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 869816002355 FMN binding site [chemical binding]; other site 869816002356 substrate binding site [chemical binding]; other site 869816002357 putative catalytic residue [active] 869816002358 Uncharacterized conserved protein [Function unknown]; Region: COG1801 869816002359 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 869816002360 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 869816002361 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 869816002362 active site 869816002363 metal binding site [ion binding]; metal-binding site 869816002364 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 869816002365 lipoyl synthase; Provisional; Region: PRK05481 869816002366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869816002367 FeS/SAM binding site; other site 869816002368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 869816002369 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 869816002370 Uncharacterized conserved protein [Function unknown]; Region: COG2445 869816002371 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 869816002372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816002373 active site 869816002374 motif I; other site 869816002375 motif II; other site 869816002376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816002377 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 869816002378 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 869816002379 dimerization interface [polypeptide binding]; other site 869816002380 ligand binding site [chemical binding]; other site 869816002381 NADP binding site [chemical binding]; other site 869816002382 catalytic site [active] 869816002383 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 869816002384 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 869816002385 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 869816002386 acyl-activating enzyme (AAE) consensus motif; other site 869816002387 AMP binding site [chemical binding]; other site 869816002388 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 869816002389 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 869816002390 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 869816002391 DltD N-terminal region; Region: DltD_N; pfam04915 869816002392 DltD central region; Region: DltD_M; pfam04918 869816002393 DltD C-terminal region; Region: DltD_C; pfam04914 869816002394 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 869816002395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 869816002396 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 869816002397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816002398 hypothetical protein; Provisional; Region: PRK13669 869816002399 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 869816002400 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 869816002401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816002402 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 869816002403 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 869816002404 interface (dimer of trimers) [polypeptide binding]; other site 869816002405 Substrate-binding/catalytic site; other site 869816002406 Zn-binding sites [ion binding]; other site 869816002407 Predicted permease [General function prediction only]; Region: COG2056 869816002408 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 869816002409 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 869816002410 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 869816002411 CoenzymeA binding site [chemical binding]; other site 869816002412 subunit interaction site [polypeptide binding]; other site 869816002413 PHB binding site; other site 869816002414 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869816002415 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 869816002416 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 869816002417 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 869816002418 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 869816002419 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 869816002420 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869816002421 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 869816002422 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 869816002423 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 869816002424 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869816002425 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 869816002426 Kinase associated protein B; Region: KapB; pfam08810 869816002427 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 869816002428 active site 869816002429 general stress protein 13; Validated; Region: PRK08059 869816002430 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 869816002431 RNA binding site [nucleotide binding]; other site 869816002432 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 869816002433 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 869816002434 putative active site [active] 869816002435 putative FMN binding site [chemical binding]; other site 869816002436 putative substrate binding site [chemical binding]; other site 869816002437 putative catalytic residue [active] 869816002438 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 869816002439 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869816002440 inhibitor-cofactor binding pocket; inhibition site 869816002441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816002442 catalytic residue [active] 869816002443 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 869816002444 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 869816002445 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 869816002446 NAD(P) binding site [chemical binding]; other site 869816002447 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 869816002448 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 869816002449 active site 869816002450 catalytic site [active] 869816002451 metal binding site [ion binding]; metal-binding site 869816002452 argininosuccinate lyase; Provisional; Region: PRK00855 869816002453 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 869816002454 active sites [active] 869816002455 tetramer interface [polypeptide binding]; other site 869816002456 argininosuccinate synthase; Provisional; Region: PRK13820 869816002457 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 869816002458 ANP binding site [chemical binding]; other site 869816002459 Substrate Binding Site II [chemical binding]; other site 869816002460 Substrate Binding Site I [chemical binding]; other site 869816002461 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 869816002462 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 869816002463 active site 869816002464 dimer interface [polypeptide binding]; other site 869816002465 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 869816002466 dimer interface [polypeptide binding]; other site 869816002467 active site 869816002468 Uncharacterized conserved protein [Function unknown]; Region: COG0398 869816002469 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 869816002470 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869816002471 Catalytic site [active] 869816002472 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 869816002473 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869816002474 Catalytic site [active] 869816002475 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 869816002476 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869816002477 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 869816002478 Part of AAA domain; Region: AAA_19; pfam13245 869816002479 Family description; Region: UvrD_C_2; pfam13538 869816002480 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869816002481 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 869816002482 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 869816002483 hypothetical protein; Provisional; Region: PRK13673 869816002484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869816002485 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816002486 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869816002487 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816002488 coenzyme A disulfide reductase; Provisional; Region: PRK13512 869816002489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869816002490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816002491 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869816002492 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869816002493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816002494 active site 869816002495 motif I; other site 869816002496 motif II; other site 869816002497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816002498 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 869816002499 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 869816002500 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 869816002501 catalytic triad [active] 869816002502 catalytic triad [active] 869816002503 oxyanion hole [active] 869816002504 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 869816002505 Clp amino terminal domain; Region: Clp_N; pfam02861 869816002506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816002507 Walker A motif; other site 869816002508 ATP binding site [chemical binding]; other site 869816002509 Walker B motif; other site 869816002510 arginine finger; other site 869816002511 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 869816002512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816002513 Walker A motif; other site 869816002514 ATP binding site [chemical binding]; other site 869816002515 Walker B motif; other site 869816002516 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869816002517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869816002518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869816002519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869816002520 dimerization interface [polypeptide binding]; other site 869816002521 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 869816002522 substrate binding site [chemical binding]; other site 869816002523 MAP domain; Region: MAP; pfam03642 869816002524 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 869816002525 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 869816002526 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 869816002527 dimer interface [polypeptide binding]; other site 869816002528 active site 869816002529 CoA binding pocket [chemical binding]; other site 869816002530 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 869816002531 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 869816002532 dimer interface [polypeptide binding]; other site 869816002533 active site 869816002534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869816002535 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816002536 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869816002537 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816002538 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 869816002539 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869816002540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816002541 dimer interface [polypeptide binding]; other site 869816002542 conserved gate region; other site 869816002543 putative PBP binding loops; other site 869816002544 ABC-ATPase subunit interface; other site 869816002545 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869816002546 dipeptide transporter; Provisional; Region: PRK10913 869816002547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816002548 dimer interface [polypeptide binding]; other site 869816002549 conserved gate region; other site 869816002550 putative PBP binding loops; other site 869816002551 ABC-ATPase subunit interface; other site 869816002552 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 869816002553 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869816002554 Walker A/P-loop; other site 869816002555 ATP binding site [chemical binding]; other site 869816002556 Q-loop/lid; other site 869816002557 ABC transporter signature motif; other site 869816002558 Walker B; other site 869816002559 D-loop; other site 869816002560 H-loop/switch region; other site 869816002561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869816002562 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869816002563 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869816002564 Walker A/P-loop; other site 869816002565 ATP binding site [chemical binding]; other site 869816002566 Q-loop/lid; other site 869816002567 ABC transporter signature motif; other site 869816002568 Walker B; other site 869816002569 D-loop; other site 869816002570 H-loop/switch region; other site 869816002571 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869816002572 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869816002573 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869816002574 peptide binding site [polypeptide binding]; other site 869816002575 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869816002576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816002577 ABC-ATPase subunit interface; other site 869816002578 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 869816002579 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869816002580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816002581 dimer interface [polypeptide binding]; other site 869816002582 conserved gate region; other site 869816002583 putative PBP binding loops; other site 869816002584 ABC-ATPase subunit interface; other site 869816002585 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 869816002586 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869816002587 Walker A/P-loop; other site 869816002588 ATP binding site [chemical binding]; other site 869816002589 Q-loop/lid; other site 869816002590 ABC transporter signature motif; other site 869816002591 Walker B; other site 869816002592 D-loop; other site 869816002593 H-loop/switch region; other site 869816002594 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869816002595 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869816002596 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869816002597 Walker A/P-loop; other site 869816002598 ATP binding site [chemical binding]; other site 869816002599 Q-loop/lid; other site 869816002600 ABC transporter signature motif; other site 869816002601 Walker B; other site 869816002602 D-loop; other site 869816002603 H-loop/switch region; other site 869816002604 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869816002605 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869816002606 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869816002607 peptide binding site [polypeptide binding]; other site 869816002608 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 869816002609 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 869816002610 active site 869816002611 HIGH motif; other site 869816002612 dimer interface [polypeptide binding]; other site 869816002613 KMSKS motif; other site 869816002614 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 869816002615 ArsC family; Region: ArsC; pfam03960 869816002616 putative catalytic residues [active] 869816002617 thiol/disulfide switch; other site 869816002618 adaptor protein; Provisional; Region: PRK02315 869816002619 Competence protein CoiA-like family; Region: CoiA; cl11541 869816002620 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 869816002621 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 869816002622 active site 869816002623 Zn binding site [ion binding]; other site 869816002624 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 869816002625 Thioredoxin; Region: Thioredoxin_5; pfam13743 869816002626 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 869816002627 apolar tunnel; other site 869816002628 heme binding site [chemical binding]; other site 869816002629 dimerization interface [polypeptide binding]; other site 869816002630 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 869816002631 putative active site [active] 869816002632 putative metal binding residues [ion binding]; other site 869816002633 signature motif; other site 869816002634 putative triphosphate binding site [ion binding]; other site 869816002635 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869816002636 synthetase active site [active] 869816002637 NTP binding site [chemical binding]; other site 869816002638 metal binding site [ion binding]; metal-binding site 869816002639 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 869816002640 ATP-NAD kinase; Region: NAD_kinase; pfam01513 869816002641 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869816002642 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869816002643 active site 869816002644 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 869816002645 MgtE intracellular N domain; Region: MgtE_N; smart00924 869816002646 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 869816002647 Divalent cation transporter; Region: MgtE; pfam01769 869816002648 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 869816002649 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 869816002650 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 869816002651 TrkA-N domain; Region: TrkA_N; pfam02254 869816002652 TrkA-C domain; Region: TrkA_C; pfam02080 869816002653 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 869816002654 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 869816002655 NAD binding site [chemical binding]; other site 869816002656 homotetramer interface [polypeptide binding]; other site 869816002657 homodimer interface [polypeptide binding]; other site 869816002658 substrate binding site [chemical binding]; other site 869816002659 active site 869816002660 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869816002661 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869816002662 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 869816002663 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 869816002664 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 869816002665 Putative esterase; Region: Esterase; pfam00756 869816002666 hypothetical protein; Provisional; Region: PRK13679 869816002667 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 869816002668 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816002669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816002670 putative substrate translocation pore; other site 869816002671 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 869816002672 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 869816002673 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869816002674 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 869816002675 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869816002676 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869816002677 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869816002678 YueH-like protein; Region: YueH; pfam14166 869816002679 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 869816002680 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 869816002681 G1 box; other site 869816002682 putative GEF interaction site [polypeptide binding]; other site 869816002683 GTP/Mg2+ binding site [chemical binding]; other site 869816002684 Switch I region; other site 869816002685 G2 box; other site 869816002686 G3 box; other site 869816002687 Switch II region; other site 869816002688 G4 box; other site 869816002689 G5 box; other site 869816002690 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 869816002691 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 869816002692 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 869816002693 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869816002694 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869816002695 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869816002696 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869816002697 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 869816002698 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 869816002699 active site 869816002700 metal binding site [ion binding]; metal-binding site 869816002701 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 869816002702 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 869816002703 IDEAL domain; Region: IDEAL; pfam08858 869816002704 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 869816002705 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 869816002706 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 869816002707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 869816002708 CAAX protease self-immunity; Region: Abi; pfam02517 869816002709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869816002710 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869816002711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 869816002712 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869816002713 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869816002714 Walker A/P-loop; other site 869816002715 ATP binding site [chemical binding]; other site 869816002716 Q-loop/lid; other site 869816002717 ABC transporter signature motif; other site 869816002718 Walker B; other site 869816002719 D-loop; other site 869816002720 H-loop/switch region; other site 869816002721 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 869816002722 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 869816002723 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869816002724 Predicted membrane protein [Function unknown]; Region: COG2259 869816002725 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 869816002726 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 869816002727 siderophore binding site; other site 869816002728 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 869816002729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816002730 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869816002731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869816002732 Coenzyme A binding pocket [chemical binding]; other site 869816002733 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 869816002734 UbiA prenyltransferase family; Region: UbiA; pfam01040 869816002735 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 869816002736 isochorismate synthases; Region: isochor_syn; TIGR00543 869816002737 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 869816002738 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 869816002739 dimer interface [polypeptide binding]; other site 869816002740 tetramer interface [polypeptide binding]; other site 869816002741 PYR/PP interface [polypeptide binding]; other site 869816002742 TPP binding site [chemical binding]; other site 869816002743 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 869816002744 TPP-binding site; other site 869816002745 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 869816002746 PGAP1-like protein; Region: PGAP1; pfam07819 869816002747 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869816002748 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 869816002749 substrate binding site [chemical binding]; other site 869816002750 oxyanion hole (OAH) forming residues; other site 869816002751 trimer interface [polypeptide binding]; other site 869816002752 Staphostatin B; Region: Staphostatin_B; pfam09023 869816002753 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 869816002754 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 869816002755 aminotransferase A; Validated; Region: PRK07683 869816002756 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869816002757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816002758 homodimer interface [polypeptide binding]; other site 869816002759 catalytic residue [active] 869816002760 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 869816002761 Acyltransferase family; Region: Acyl_transf_3; pfam01757 869816002762 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869816002763 MarR family; Region: MarR; pfam01047 869816002764 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 869816002765 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 869816002766 amidase catalytic site [active] 869816002767 Zn binding residues [ion binding]; other site 869816002768 substrate binding site [chemical binding]; other site 869816002769 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 869816002770 Lysozyme subfamily 2; Region: LYZ2; smart00047 869816002771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816002772 Coenzyme A binding pocket [chemical binding]; other site 869816002773 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 869816002774 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869816002775 Beta-lactamase; Region: Beta-lactamase; pfam00144 869816002776 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 869816002777 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 869816002778 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 869816002779 Subunit I/III interface [polypeptide binding]; other site 869816002780 Subunit III/IV interface [polypeptide binding]; other site 869816002781 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 869816002782 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 869816002783 D-pathway; other site 869816002784 Putative ubiquinol binding site [chemical binding]; other site 869816002785 Low-spin heme (heme b) binding site [chemical binding]; other site 869816002786 Putative water exit pathway; other site 869816002787 Binuclear center (heme o3/CuB) [ion binding]; other site 869816002788 K-pathway; other site 869816002789 Putative proton exit pathway; other site 869816002790 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 869816002791 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 869816002792 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 869816002793 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 869816002794 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 869816002795 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 869816002796 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 869816002797 homodimer interface [polypeptide binding]; other site 869816002798 NADP binding site [chemical binding]; other site 869816002799 substrate binding site [chemical binding]; other site 869816002800 AIR carboxylase; Region: AIRC; cl00310 869816002801 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 869816002802 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 869816002803 NAD binding site [chemical binding]; other site 869816002804 ATP-grasp domain; Region: ATP-grasp; pfam02222 869816002805 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 869816002806 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 869816002807 ATP binding site [chemical binding]; other site 869816002808 active site 869816002809 substrate binding site [chemical binding]; other site 869816002810 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 869816002811 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 869816002812 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 869816002813 putative active site [active] 869816002814 catalytic triad [active] 869816002815 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 869816002816 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 869816002817 dimerization interface [polypeptide binding]; other site 869816002818 ATP binding site [chemical binding]; other site 869816002819 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 869816002820 dimerization interface [polypeptide binding]; other site 869816002821 ATP binding site [chemical binding]; other site 869816002822 amidophosphoribosyltransferase; Provisional; Region: PRK07272 869816002823 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 869816002824 tetramer interface [polypeptide binding]; other site 869816002825 active site 869816002826 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869816002827 active site 869816002828 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 869816002829 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 869816002830 dimerization interface [polypeptide binding]; other site 869816002831 putative ATP binding site [chemical binding]; other site 869816002832 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 869816002833 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 869816002834 active site 869816002835 substrate binding site [chemical binding]; other site 869816002836 cosubstrate binding site; other site 869816002837 catalytic site [active] 869816002838 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 869816002839 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 869816002840 purine monophosphate binding site [chemical binding]; other site 869816002841 dimer interface [polypeptide binding]; other site 869816002842 putative catalytic residues [active] 869816002843 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 869816002844 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 869816002845 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 869816002846 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 869816002847 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 869816002848 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 869816002849 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869816002850 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869816002851 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869816002852 Walker A/P-loop; other site 869816002853 ATP binding site [chemical binding]; other site 869816002854 Q-loop/lid; other site 869816002855 ABC transporter signature motif; other site 869816002856 Walker B; other site 869816002857 D-loop; other site 869816002858 H-loop/switch region; other site 869816002859 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 869816002860 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869816002861 Walker A/P-loop; other site 869816002862 ATP binding site [chemical binding]; other site 869816002863 Q-loop/lid; other site 869816002864 ABC transporter signature motif; other site 869816002865 Walker B; other site 869816002866 D-loop; other site 869816002867 H-loop/switch region; other site 869816002868 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 869816002869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869816002870 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816002871 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869816002872 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816002873 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 869816002874 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 869816002875 putative RNA binding site [nucleotide binding]; other site 869816002876 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869816002877 Domain of unknown function (DUF697); Region: DUF697; cl12064 869816002878 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869816002879 dimerization domain swap beta strand [polypeptide binding]; other site 869816002880 regulatory protein interface [polypeptide binding]; other site 869816002881 active site 869816002882 regulatory phosphorylation site [posttranslational modification]; other site 869816002883 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 869816002884 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869816002885 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869816002886 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869816002887 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 869816002888 catalytic residues [active] 869816002889 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 869816002890 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 869816002891 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 869816002892 TrkA-N domain; Region: TrkA_N; pfam02254 869816002893 TrkA-C domain; Region: TrkA_C; pfam02080 869816002894 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869816002895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 869816002896 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869816002897 hypothetical protein; Provisional; Region: PRK13667 869816002898 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869816002899 active site 869816002900 catalytic residues [active] 869816002901 metal binding site [ion binding]; metal-binding site 869816002902 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 869816002903 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 869816002904 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 869816002905 TPP-binding site [chemical binding]; other site 869816002906 tetramer interface [polypeptide binding]; other site 869816002907 heterodimer interface [polypeptide binding]; other site 869816002908 phosphorylation loop region [posttranslational modification] 869816002909 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 869816002910 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 869816002911 alpha subunit interface [polypeptide binding]; other site 869816002912 TPP binding site [chemical binding]; other site 869816002913 heterodimer interface [polypeptide binding]; other site 869816002914 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869816002915 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 869816002916 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869816002917 E3 interaction surface; other site 869816002918 lipoyl attachment site [posttranslational modification]; other site 869816002919 e3 binding domain; Region: E3_binding; pfam02817 869816002920 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869816002921 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 869816002922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869816002923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816002924 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869816002925 hypothetical protein; Provisional; Region: PRK04387 869816002926 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869816002927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816002928 non-specific DNA binding site [nucleotide binding]; other site 869816002929 salt bridge; other site 869816002930 sequence-specific DNA binding site [nucleotide binding]; other site 869816002931 Cupin domain; Region: Cupin_2; pfam07883 869816002932 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869816002933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816002934 Walker A/P-loop; other site 869816002935 ATP binding site [chemical binding]; other site 869816002936 Q-loop/lid; other site 869816002937 ABC transporter signature motif; other site 869816002938 Walker B; other site 869816002939 D-loop; other site 869816002940 H-loop/switch region; other site 869816002941 TOBE domain; Region: TOBE_2; pfam08402 869816002942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816002943 putative PBP binding loops; other site 869816002944 dimer interface [polypeptide binding]; other site 869816002945 ABC-ATPase subunit interface; other site 869816002946 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869816002947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816002948 dimer interface [polypeptide binding]; other site 869816002949 conserved gate region; other site 869816002950 putative PBP binding loops; other site 869816002951 ABC-ATPase subunit interface; other site 869816002952 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 869816002953 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 869816002954 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 869816002955 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 869816002956 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 869816002957 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 869816002958 manganese transport protein MntH; Reviewed; Region: PRK00701 869816002959 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 869816002960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 869816002961 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 869816002962 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 869816002963 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 869816002964 active site 869816002965 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 869816002966 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 869816002967 G1 box; other site 869816002968 putative GEF interaction site [polypeptide binding]; other site 869816002969 GTP/Mg2+ binding site [chemical binding]; other site 869816002970 Switch I region; other site 869816002971 G2 box; other site 869816002972 G3 box; other site 869816002973 Switch II region; other site 869816002974 G4 box; other site 869816002975 G5 box; other site 869816002976 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 869816002977 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 869816002978 hypothetical protein; Provisional; Region: PRK13666 869816002979 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 869816002980 pyruvate carboxylase; Reviewed; Region: PRK12999 869816002981 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869816002982 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869816002983 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 869816002984 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 869816002985 active site 869816002986 catalytic residues [active] 869816002987 metal binding site [ion binding]; metal-binding site 869816002988 homodimer binding site [polypeptide binding]; other site 869816002989 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869816002990 carboxyltransferase (CT) interaction site; other site 869816002991 biotinylation site [posttranslational modification]; other site 869816002992 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 869816002993 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 869816002994 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 869816002995 UbiA prenyltransferase family; Region: UbiA; pfam01040 869816002996 Predicted membrane protein [Function unknown]; Region: COG2322 869816002997 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 869816002998 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 869816002999 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 869816003000 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 869816003001 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 869816003002 putative active site [active] 869816003003 catalytic site [active] 869816003004 putative metal binding site [ion binding]; other site 869816003005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 869816003006 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 869816003007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816003008 S-adenosylmethionine binding site [chemical binding]; other site 869816003009 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 869816003010 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 869816003011 active site 869816003012 (T/H)XGH motif; other site 869816003013 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 869816003014 hypothetical protein; Provisional; Region: PRK13670 869816003015 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 869816003016 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 869816003017 heme uptake protein IsdB; Region: IsdB; TIGR03657 869816003018 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816003019 NEAr Transporter domain; Region: NEAT; smart00725 869816003020 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 869816003021 heme-binding site [chemical binding]; other site 869816003022 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869816003023 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 869816003024 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 869816003025 heme-binding site [chemical binding]; other site 869816003026 heme uptake protein IsdC; Region: IsdC; TIGR03656 869816003027 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 869816003028 heme-binding site [chemical binding]; other site 869816003029 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 869816003030 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 869816003031 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 869816003032 intersubunit interface [polypeptide binding]; other site 869816003033 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869816003034 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816003035 ABC-ATPase subunit interface; other site 869816003036 dimer interface [polypeptide binding]; other site 869816003037 putative PBP binding regions; other site 869816003038 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 869816003039 active site 869816003040 catalytic site [active] 869816003041 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 869816003042 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869816003043 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 869816003044 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869816003045 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 869816003046 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 869816003047 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 869816003048 dimer interface [polypeptide binding]; other site 869816003049 motif 1; other site 869816003050 active site 869816003051 motif 2; other site 869816003052 motif 3; other site 869816003053 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 869816003054 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869816003055 putative tRNA-binding site [nucleotide binding]; other site 869816003056 B3/4 domain; Region: B3_4; pfam03483 869816003057 tRNA synthetase B5 domain; Region: B5; smart00874 869816003058 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 869816003059 dimer interface [polypeptide binding]; other site 869816003060 motif 1; other site 869816003061 motif 3; other site 869816003062 motif 2; other site 869816003063 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 869816003064 ribonuclease HIII; Provisional; Region: PRK00996 869816003065 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 869816003066 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 869816003067 RNA/DNA hybrid binding site [nucleotide binding]; other site 869816003068 active site 869816003069 Cell division protein ZapA; Region: ZapA; cl01146 869816003070 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 869816003071 Colicin V production protein; Region: Colicin_V; pfam02674 869816003072 hypothetical protein; Provisional; Region: PRK08609 869816003073 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 869816003074 active site 869816003075 primer binding site [nucleotide binding]; other site 869816003076 NTP binding site [chemical binding]; other site 869816003077 metal binding triad [ion binding]; metal-binding site 869816003078 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 869816003079 active site 869816003080 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 869816003081 MutS domain III; Region: MutS_III; pfam05192 869816003082 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 869816003083 Walker A/P-loop; other site 869816003084 ATP binding site [chemical binding]; other site 869816003085 Q-loop/lid; other site 869816003086 ABC transporter signature motif; other site 869816003087 Walker B; other site 869816003088 D-loop; other site 869816003089 H-loop/switch region; other site 869816003090 Smr domain; Region: Smr; pfam01713 869816003091 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869816003092 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869816003093 catalytic residues [active] 869816003094 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 869816003095 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 869816003096 GIY-YIG motif/motif A; other site 869816003097 active site 869816003098 catalytic site [active] 869816003099 putative DNA binding site [nucleotide binding]; other site 869816003100 metal binding site [ion binding]; metal-binding site 869816003101 UvrB/uvrC motif; Region: UVR; pfam02151 869816003102 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 869816003103 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 869816003104 putative Iron-sulfur protein interface [polypeptide binding]; other site 869816003105 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 869816003106 proximal heme binding site [chemical binding]; other site 869816003107 distal heme binding site [chemical binding]; other site 869816003108 putative dimer interface [polypeptide binding]; other site 869816003109 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 869816003110 L-aspartate oxidase; Provisional; Region: PRK06175 869816003111 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 869816003112 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 869816003113 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 869816003114 glutamate racemase; Provisional; Region: PRK00865 869816003115 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 869816003116 active site 869816003117 dimerization interface [polypeptide binding]; other site 869816003118 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 869816003119 active site 869816003120 metal binding site [ion binding]; metal-binding site 869816003121 homotetramer interface [polypeptide binding]; other site 869816003122 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 869816003123 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 869816003124 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 869816003125 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 869816003126 beta-channel forming cytolysin; Region: hlyII; TIGR01002 869816003127 superantigen-like protein; Reviewed; Region: PRK13350 869816003128 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816003129 superantigen-like protein; Reviewed; Region: PRK13349 869816003130 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816003131 superantigen-like protein; Reviewed; Region: PRK13043 869816003132 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816003133 ornithine carbamoyltransferase; Provisional; Region: PRK04284 869816003134 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869816003135 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869816003136 carbamate kinase; Reviewed; Region: PRK12686 869816003137 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869816003138 putative substrate binding site [chemical binding]; other site 869816003139 nucleotide binding site [chemical binding]; other site 869816003140 nucleotide binding site [chemical binding]; other site 869816003141 homodimer interface [polypeptide binding]; other site 869816003142 Predicted membrane protein [Function unknown]; Region: COG1288 869816003143 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 869816003144 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 869816003145 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 869816003146 gating phenylalanine in ion channel; other site 869816003147 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 869816003148 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 869816003149 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 869816003150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816003151 motif II; other site 869816003152 hypothetical protein; Provisional; Region: PRK13688 869816003153 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 869816003154 Coenzyme A binding pocket [chemical binding]; other site 869816003155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 869816003156 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 869816003157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 869816003158 MraZ protein; Region: MraZ; pfam02381 869816003159 MraZ protein; Region: MraZ; pfam02381 869816003160 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 869816003161 MraW methylase family; Region: Methyltransf_5; pfam01795 869816003162 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 869816003163 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869816003164 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869816003165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869816003166 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 869816003167 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 869816003168 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 869816003169 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 869816003170 Mg++ binding site [ion binding]; other site 869816003171 putative catalytic motif [active] 869816003172 putative substrate binding site [chemical binding]; other site 869816003173 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 869816003174 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 869816003175 NAD binding site [chemical binding]; other site 869816003176 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869816003177 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869816003178 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 869816003179 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 869816003180 Cell division protein FtsQ; Region: FtsQ; pfam03799 869816003181 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 869816003182 Cell division protein FtsA; Region: FtsA; smart00842 869816003183 Cell division protein FtsA; Region: FtsA; pfam14450 869816003184 cell division protein FtsZ; Validated; Region: PRK09330 869816003185 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 869816003186 nucleotide binding site [chemical binding]; other site 869816003187 SulA interaction site; other site 869816003188 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 869816003189 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 869816003190 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 869816003191 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869816003192 catalytic residue [active] 869816003193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 869816003194 YGGT family; Region: YGGT; pfam02325 869816003195 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 869816003196 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869816003197 RNA binding surface [nucleotide binding]; other site 869816003198 DivIVA protein; Region: DivIVA; pfam05103 869816003199 DivIVA domain; Region: DivI1A_domain; TIGR03544 869816003200 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 869816003201 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869816003202 HIGH motif; other site 869816003203 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869816003204 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869816003205 active site 869816003206 KMSKS motif; other site 869816003207 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 869816003208 tRNA binding surface [nucleotide binding]; other site 869816003209 anticodon binding site; other site 869816003210 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869816003211 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 869816003212 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869816003213 active site 869816003214 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 869816003215 lipoprotein signal peptidase; Provisional; Region: PRK14787 869816003216 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869816003217 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869816003218 RNA binding surface [nucleotide binding]; other site 869816003219 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869816003220 active site 869816003221 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 869816003222 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 869816003223 uracil transporter; Provisional; Region: PRK10720 869816003224 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 869816003225 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869816003226 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869816003227 dihydroorotase; Validated; Region: pyrC; PRK09357 869816003228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 869816003229 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 869816003230 active site 869816003231 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 869816003232 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 869816003233 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 869816003234 catalytic site [active] 869816003235 subunit interface [polypeptide binding]; other site 869816003236 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 869816003237 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869816003238 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869816003239 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 869816003240 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869816003241 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869816003242 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 869816003243 IMP binding site; other site 869816003244 dimer interface [polypeptide binding]; other site 869816003245 interdomain contacts; other site 869816003246 partial ornithine binding site; other site 869816003247 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 869816003248 active site 869816003249 dimer interface [polypeptide binding]; other site 869816003250 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869816003251 active site 869816003252 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 869816003253 dimer interface [polypeptide binding]; other site 869816003254 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 869816003255 Domain of unknown function (DUF814); Region: DUF814; pfam05670 869816003256 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 869816003257 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 869816003258 catalytic site [active] 869816003259 G-X2-G-X-G-K; other site 869816003260 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 869816003261 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 869816003262 Flavoprotein; Region: Flavoprotein; pfam02441 869816003263 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 869816003264 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 869816003265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816003266 ATP binding site [chemical binding]; other site 869816003267 putative Mg++ binding site [ion binding]; other site 869816003268 helicase superfamily c-terminal domain; Region: HELICc; smart00490 869816003269 nucleotide binding region [chemical binding]; other site 869816003270 ATP-binding site [chemical binding]; other site 869816003271 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 869816003272 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869816003273 active site 869816003274 catalytic residues [active] 869816003275 metal binding site [ion binding]; metal-binding site 869816003276 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 869816003277 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 869816003278 putative active site [active] 869816003279 substrate binding site [chemical binding]; other site 869816003280 putative cosubstrate binding site; other site 869816003281 catalytic site [active] 869816003282 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 869816003283 substrate binding site [chemical binding]; other site 869816003284 16S rRNA methyltransferase B; Provisional; Region: PRK14902 869816003285 NusB family; Region: NusB; pfam01029 869816003286 putative RNA binding site [nucleotide binding]; other site 869816003287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816003288 S-adenosylmethionine binding site [chemical binding]; other site 869816003289 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 869816003290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869816003291 FeS/SAM binding site; other site 869816003292 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 869816003293 Protein phosphatase 2C; Region: PP2C; pfam00481 869816003294 active site 869816003295 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 869816003296 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 869816003297 active site 869816003298 ATP binding site [chemical binding]; other site 869816003299 substrate binding site [chemical binding]; other site 869816003300 activation loop (A-loop); other site 869816003301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 869816003302 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869816003303 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869816003304 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869816003305 Predicted GTPases [General function prediction only]; Region: COG1162 869816003306 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 869816003307 RNA binding site [nucleotide binding]; other site 869816003308 homodimer interface [polypeptide binding]; other site 869816003309 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 869816003310 GTPase/Zn-binding domain interface [polypeptide binding]; other site 869816003311 GTP/Mg2+ binding site [chemical binding]; other site 869816003312 G4 box; other site 869816003313 G5 box; other site 869816003314 G1 box; other site 869816003315 Switch I region; other site 869816003316 G2 box; other site 869816003317 G3 box; other site 869816003318 Switch II region; other site 869816003319 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 869816003320 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 869816003321 substrate binding site [chemical binding]; other site 869816003322 hexamer interface [polypeptide binding]; other site 869816003323 metal binding site [ion binding]; metal-binding site 869816003324 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 869816003325 Thiamine pyrophosphokinase; Region: TPK; cd07995 869816003326 active site 869816003327 dimerization interface [polypeptide binding]; other site 869816003328 thiamine binding site [chemical binding]; other site 869816003329 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 869816003330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869816003331 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 869816003332 DAK2 domain; Region: Dak2; pfam02734 869816003333 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 869816003334 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 869816003335 generic binding surface II; other site 869816003336 ssDNA binding site; other site 869816003337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816003338 ATP binding site [chemical binding]; other site 869816003339 putative Mg++ binding site [ion binding]; other site 869816003340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869816003341 nucleotide binding region [chemical binding]; other site 869816003342 ATP-binding site [chemical binding]; other site 869816003343 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 869816003344 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 869816003345 active site 2 [active] 869816003346 active site 1 [active] 869816003347 putative phosphate acyltransferase; Provisional; Region: PRK05331 869816003348 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 869816003349 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869816003350 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 869816003351 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 869816003352 NAD(P) binding site [chemical binding]; other site 869816003353 homotetramer interface [polypeptide binding]; other site 869816003354 homodimer interface [polypeptide binding]; other site 869816003355 active site 869816003356 acyl carrier protein; Provisional; Region: acpP; PRK00982 869816003357 ribonuclease III; Reviewed; Region: rnc; PRK00102 869816003358 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 869816003359 dimerization interface [polypeptide binding]; other site 869816003360 active site 869816003361 metal binding site [ion binding]; metal-binding site 869816003362 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 869816003363 dsRNA binding site [nucleotide binding]; other site 869816003364 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 869816003365 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869816003366 Walker A/P-loop; other site 869816003367 ATP binding site [chemical binding]; other site 869816003368 Q-loop/lid; other site 869816003369 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 869816003370 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869816003371 ABC transporter signature motif; other site 869816003372 Walker B; other site 869816003373 D-loop; other site 869816003374 H-loop/switch region; other site 869816003375 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 869816003376 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 869816003377 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869816003378 P loop; other site 869816003379 GTP binding site [chemical binding]; other site 869816003380 putative DNA-binding protein; Validated; Region: PRK00118 869816003381 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 869816003382 signal recognition particle protein; Provisional; Region: PRK10867 869816003383 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 869816003384 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869816003385 P loop; other site 869816003386 GTP binding site [chemical binding]; other site 869816003387 Signal peptide binding domain; Region: SRP_SPB; pfam02978 869816003388 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 869816003389 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 869816003390 RimM N-terminal domain; Region: RimM; pfam01782 869816003391 PRC-barrel domain; Region: PRC; pfam05239 869816003392 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 869816003393 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 869816003394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869816003395 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869816003396 Predicted membrane protein [Function unknown]; Region: COG4485 869816003397 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 869816003398 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 869816003399 GTP/Mg2+ binding site [chemical binding]; other site 869816003400 G4 box; other site 869816003401 G5 box; other site 869816003402 G1 box; other site 869816003403 Switch I region; other site 869816003404 G2 box; other site 869816003405 G3 box; other site 869816003406 Switch II region; other site 869816003407 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 869816003408 RNA/DNA hybrid binding site [nucleotide binding]; other site 869816003409 active site 869816003410 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 869816003411 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 869816003412 CoA-ligase; Region: Ligase_CoA; pfam00549 869816003413 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 869816003414 CoA binding domain; Region: CoA_binding; pfam02629 869816003415 CoA-ligase; Region: Ligase_CoA; pfam00549 869816003416 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869816003417 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869816003418 CHAP domain; Region: CHAP; pfam05257 869816003419 FemAB family; Region: FemAB; pfam02388 869816003420 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 869816003421 DNA protecting protein DprA; Region: dprA; TIGR00732 869816003422 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 869816003423 DNA topoisomerase I; Validated; Region: PRK05582 869816003424 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 869816003425 active site 869816003426 interdomain interaction site; other site 869816003427 putative metal-binding site [ion binding]; other site 869816003428 nucleotide binding site [chemical binding]; other site 869816003429 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 869816003430 domain I; other site 869816003431 DNA binding groove [nucleotide binding] 869816003432 phosphate binding site [ion binding]; other site 869816003433 domain II; other site 869816003434 domain III; other site 869816003435 nucleotide binding site [chemical binding]; other site 869816003436 catalytic site [active] 869816003437 domain IV; other site 869816003438 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869816003439 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869816003440 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 869816003441 Glucose inhibited division protein A; Region: GIDA; pfam01134 869816003442 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 869816003443 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869816003444 active site 869816003445 DNA binding site [nucleotide binding] 869816003446 Int/Topo IB signature motif; other site 869816003447 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 869816003448 active site 869816003449 HslU subunit interaction site [polypeptide binding]; other site 869816003450 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 869816003451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816003452 Walker A motif; other site 869816003453 ATP binding site [chemical binding]; other site 869816003454 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 869816003455 Walker B motif; other site 869816003456 arginine finger; other site 869816003457 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869816003458 transcriptional repressor CodY; Validated; Region: PRK04158 869816003459 CodY GAF-like domain; Region: CodY; pfam06018 869816003460 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 869816003461 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 869816003462 rRNA interaction site [nucleotide binding]; other site 869816003463 S8 interaction site; other site 869816003464 putative laminin-1 binding site; other site 869816003465 elongation factor Ts; Provisional; Region: tsf; PRK09377 869816003466 UBA/TS-N domain; Region: UBA; pfam00627 869816003467 Elongation factor TS; Region: EF_TS; pfam00889 869816003468 Elongation factor TS; Region: EF_TS; pfam00889 869816003469 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 869816003470 putative nucleotide binding site [chemical binding]; other site 869816003471 uridine monophosphate binding site [chemical binding]; other site 869816003472 homohexameric interface [polypeptide binding]; other site 869816003473 ribosome recycling factor; Reviewed; Region: frr; PRK00083 869816003474 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 869816003475 hinge region; other site 869816003476 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 869816003477 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 869816003478 catalytic residue [active] 869816003479 putative FPP diphosphate binding site; other site 869816003480 putative FPP binding hydrophobic cleft; other site 869816003481 dimer interface [polypeptide binding]; other site 869816003482 putative IPP diphosphate binding site; other site 869816003483 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 869816003484 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 869816003485 RIP metalloprotease RseP; Region: TIGR00054 869816003486 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869816003487 active site 869816003488 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 869816003489 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 869816003490 protein binding site [polypeptide binding]; other site 869816003491 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869816003492 putative substrate binding region [chemical binding]; other site 869816003493 prolyl-tRNA synthetase; Provisional; Region: PRK09194 869816003494 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 869816003495 dimer interface [polypeptide binding]; other site 869816003496 motif 1; other site 869816003497 active site 869816003498 motif 2; other site 869816003499 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 869816003500 putative deacylase active site [active] 869816003501 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869816003502 active site 869816003503 motif 3; other site 869816003504 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 869816003505 anticodon binding site; other site 869816003506 DNA polymerase III PolC; Validated; Region: polC; PRK00448 869816003507 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 869816003508 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 869816003509 generic binding surface II; other site 869816003510 generic binding surface I; other site 869816003511 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 869816003512 active site 869816003513 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869816003514 active site 869816003515 catalytic site [active] 869816003516 substrate binding site [chemical binding]; other site 869816003517 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 869816003518 ribosome maturation protein RimP; Reviewed; Region: PRK00092 869816003519 Sm and related proteins; Region: Sm_like; cl00259 869816003520 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 869816003521 putative oligomer interface [polypeptide binding]; other site 869816003522 putative RNA binding site [nucleotide binding]; other site 869816003523 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 869816003524 NusA N-terminal domain; Region: NusA_N; pfam08529 869816003525 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 869816003526 RNA binding site [nucleotide binding]; other site 869816003527 homodimer interface [polypeptide binding]; other site 869816003528 NusA-like KH domain; Region: KH_5; pfam13184 869816003529 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 869816003530 G-X-X-G motif; other site 869816003531 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 869816003532 putative RNA binding cleft [nucleotide binding]; other site 869816003533 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 869816003534 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869816003535 translation initiation factor IF-2; Region: IF-2; TIGR00487 869816003536 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869816003537 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 869816003538 G1 box; other site 869816003539 putative GEF interaction site [polypeptide binding]; other site 869816003540 GTP/Mg2+ binding site [chemical binding]; other site 869816003541 Switch I region; other site 869816003542 G2 box; other site 869816003543 G3 box; other site 869816003544 Switch II region; other site 869816003545 G4 box; other site 869816003546 G5 box; other site 869816003547 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 869816003548 Translation-initiation factor 2; Region: IF-2; pfam11987 869816003549 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 869816003550 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 869816003551 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 869816003552 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 869816003553 RNA binding site [nucleotide binding]; other site 869816003554 active site 869816003555 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 869816003556 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 869816003557 active site 869816003558 Riboflavin kinase; Region: Flavokinase; smart00904 869816003559 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 869816003560 16S/18S rRNA binding site [nucleotide binding]; other site 869816003561 S13e-L30e interaction site [polypeptide binding]; other site 869816003562 25S rRNA binding site [nucleotide binding]; other site 869816003563 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 869816003564 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 869816003565 RNase E interface [polypeptide binding]; other site 869816003566 trimer interface [polypeptide binding]; other site 869816003567 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 869816003568 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 869816003569 RNase E interface [polypeptide binding]; other site 869816003570 trimer interface [polypeptide binding]; other site 869816003571 active site 869816003572 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 869816003573 putative nucleic acid binding region [nucleotide binding]; other site 869816003574 G-X-X-G motif; other site 869816003575 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 869816003576 RNA binding site [nucleotide binding]; other site 869816003577 domain interface; other site 869816003578 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869816003579 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869816003580 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869816003581 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 869816003582 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869816003583 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869816003584 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 869816003585 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 869816003586 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869816003587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 869816003588 DNA-binding site [nucleotide binding]; DNA binding site 869816003589 UTRA domain; Region: UTRA; pfam07702 869816003590 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869816003591 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869816003592 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869816003593 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 869816003594 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869816003595 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 869816003596 classical (c) SDRs; Region: SDR_c; cd05233 869816003597 NAD(P) binding site [chemical binding]; other site 869816003598 active site 869816003599 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 869816003600 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 869816003601 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 869816003602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816003603 non-specific DNA binding site [nucleotide binding]; other site 869816003604 salt bridge; other site 869816003605 sequence-specific DNA binding site [nucleotide binding]; other site 869816003606 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 869816003607 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 869816003608 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 869816003609 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 869816003610 putative MPT binding site; other site 869816003611 recombinase A; Provisional; Region: recA; PRK09354 869816003612 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 869816003613 hexamer interface [polypeptide binding]; other site 869816003614 Walker A motif; other site 869816003615 ATP binding site [chemical binding]; other site 869816003616 Walker B motif; other site 869816003617 phosphodiesterase; Provisional; Region: PRK12704 869816003618 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869816003619 Zn2+ binding site [ion binding]; other site 869816003620 Mg2+ binding site [ion binding]; other site 869816003621 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 869816003622 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869816003623 putative active site [active] 869816003624 metal binding site [ion binding]; metal-binding site 869816003625 homodimer binding site [polypeptide binding]; other site 869816003626 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 869816003627 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 869816003628 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 869816003629 dimer interface [polypeptide binding]; other site 869816003630 PYR/PP interface [polypeptide binding]; other site 869816003631 TPP binding site [chemical binding]; other site 869816003632 substrate binding site [chemical binding]; other site 869816003633 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 869816003634 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 869816003635 TPP-binding site [chemical binding]; other site 869816003636 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 869816003637 Uncharacterized conserved protein [Function unknown]; Region: COG0011 869816003638 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 869816003639 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 869816003640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869816003641 FeS/SAM binding site; other site 869816003642 TRAM domain; Region: TRAM; pfam01938 869816003643 Predicted membrane protein [Function unknown]; Region: COG4550 869816003644 Predicted membrane protein [Function unknown]; Region: COG4732 869816003645 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 869816003646 MutS domain I; Region: MutS_I; pfam01624 869816003647 MutS domain II; Region: MutS_II; pfam05188 869816003648 MutS domain III; Region: MutS_III; pfam05192 869816003649 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 869816003650 Walker A/P-loop; other site 869816003651 ATP binding site [chemical binding]; other site 869816003652 Q-loop/lid; other site 869816003653 ABC transporter signature motif; other site 869816003654 Walker B; other site 869816003655 D-loop; other site 869816003656 H-loop/switch region; other site 869816003657 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 869816003658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816003659 ATP binding site [chemical binding]; other site 869816003660 Mg2+ binding site [ion binding]; other site 869816003661 G-X-G motif; other site 869816003662 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 869816003663 ATP binding site [chemical binding]; other site 869816003664 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 869816003665 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 869816003666 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869816003667 amphipathic channel; other site 869816003668 Asn-Pro-Ala signature motifs; other site 869816003669 glycerol kinase; Provisional; Region: glpK; PRK00047 869816003670 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 869816003671 N- and C-terminal domain interface [polypeptide binding]; other site 869816003672 active site 869816003673 MgATP binding site [chemical binding]; other site 869816003674 catalytic site [active] 869816003675 metal binding site [ion binding]; metal-binding site 869816003676 glycerol binding site [chemical binding]; other site 869816003677 homotetramer interface [polypeptide binding]; other site 869816003678 homodimer interface [polypeptide binding]; other site 869816003679 FBP binding site [chemical binding]; other site 869816003680 protein IIAGlc interface [polypeptide binding]; other site 869816003681 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 869816003682 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 869816003683 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869816003684 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 869816003685 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 869816003686 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 869816003687 bacterial Hfq-like; Region: Hfq; cd01716 869816003688 hexamer interface [polypeptide binding]; other site 869816003689 Sm1 motif; other site 869816003690 RNA binding site [nucleotide binding]; other site 869816003691 Sm2 motif; other site 869816003692 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 869816003693 catalytic residues [active] 869816003694 dimer interface [polypeptide binding]; other site 869816003695 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 869816003696 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 869816003697 HflX GTPase family; Region: HflX; cd01878 869816003698 G1 box; other site 869816003699 GTP/Mg2+ binding site [chemical binding]; other site 869816003700 Switch I region; other site 869816003701 G2 box; other site 869816003702 G3 box; other site 869816003703 Switch II region; other site 869816003704 G4 box; other site 869816003705 G5 box; other site 869816003706 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 869816003707 Aluminium resistance protein; Region: Alum_res; pfam06838 869816003708 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 869816003709 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 869816003710 DNA binding residues [nucleotide binding] 869816003711 putative dimer interface [polypeptide binding]; other site 869816003712 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 869816003713 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 869816003714 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 869816003715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 869816003716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 869816003717 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 869816003718 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 869816003719 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869816003720 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869816003721 catalytic residue [active] 869816003722 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 869816003723 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 869816003724 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 869816003725 putative active site [active] 869816003726 catalytic site [active] 869816003727 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 869816003728 putative active site [active] 869816003729 catalytic site [active] 869816003730 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869816003731 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869816003732 Walker A/P-loop; other site 869816003733 ATP binding site [chemical binding]; other site 869816003734 Q-loop/lid; other site 869816003735 ABC transporter signature motif; other site 869816003736 Walker B; other site 869816003737 D-loop; other site 869816003738 H-loop/switch region; other site 869816003739 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 869816003740 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869816003741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 869816003742 Histidine kinase; Region: HisKA_3; pfam07730 869816003743 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 869816003744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869816003745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816003746 active site 869816003747 phosphorylation site [posttranslational modification] 869816003748 intermolecular recognition site; other site 869816003749 dimerization interface [polypeptide binding]; other site 869816003750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869816003751 DNA binding residues [nucleotide binding] 869816003752 dimerization interface [polypeptide binding]; other site 869816003753 Staphylococcal nuclease homologues; Region: SNc; smart00318 869816003754 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 869816003755 Catalytic site; other site 869816003756 AAA domain; Region: AAA_11; pfam13086 869816003757 aspartate kinase; Reviewed; Region: PRK09034 869816003758 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 869816003759 putative catalytic residues [active] 869816003760 putative nucleotide binding site [chemical binding]; other site 869816003761 putative aspartate binding site [chemical binding]; other site 869816003762 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 869816003763 allosteric regulatory residue; other site 869816003764 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 869816003765 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 869816003766 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 869816003767 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 869816003768 threonine synthase; Reviewed; Region: PRK06721 869816003769 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 869816003770 homodimer interface [polypeptide binding]; other site 869816003771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816003772 catalytic residue [active] 869816003773 homoserine kinase; Provisional; Region: PRK01212 869816003774 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869816003775 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869816003776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816003777 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869816003778 active site 869816003779 motif I; other site 869816003780 motif II; other site 869816003781 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869816003782 lysine transporter; Provisional; Region: PRK10836 869816003783 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 869816003784 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 869816003785 tetramer interface [polypeptide binding]; other site 869816003786 heme binding pocket [chemical binding]; other site 869816003787 NADPH binding site [chemical binding]; other site 869816003788 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 869816003789 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 869816003790 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 869816003791 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869816003792 active site 869816003793 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 869816003794 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 869816003795 LexA repressor; Validated; Region: PRK00215 869816003796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869816003797 putative DNA binding site [nucleotide binding]; other site 869816003798 putative Zn2+ binding site [ion binding]; other site 869816003799 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869816003800 Catalytic site [active] 869816003801 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 869816003802 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 869816003803 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869816003804 TPP-binding site [chemical binding]; other site 869816003805 dimer interface [polypeptide binding]; other site 869816003806 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869816003807 PYR/PP interface [polypeptide binding]; other site 869816003808 dimer interface [polypeptide binding]; other site 869816003809 TPP binding site [chemical binding]; other site 869816003810 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869816003811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 869816003812 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 869816003813 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 869816003814 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 869816003815 active site 869816003816 metal binding site [ion binding]; metal-binding site 869816003817 DNA binding site [nucleotide binding] 869816003818 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 869816003819 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 869816003820 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 869816003821 Walker A/P-loop; other site 869816003822 ATP binding site [chemical binding]; other site 869816003823 Q-loop/lid; other site 869816003824 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 869816003825 ABC transporter signature motif; other site 869816003826 Walker B; other site 869816003827 D-loop; other site 869816003828 H-loop/switch region; other site 869816003829 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 869816003830 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 869816003831 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 869816003832 aconitate hydratase; Validated; Region: PRK09277 869816003833 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 869816003834 substrate binding site [chemical binding]; other site 869816003835 ligand binding site [chemical binding]; other site 869816003836 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 869816003837 substrate binding site [chemical binding]; other site 869816003838 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869816003839 active site 869816003840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 869816003841 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 869816003842 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 869816003843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816003844 ATP binding site [chemical binding]; other site 869816003845 Mg2+ binding site [ion binding]; other site 869816003846 G-X-G motif; other site 869816003847 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869816003848 anchoring element; other site 869816003849 dimer interface [polypeptide binding]; other site 869816003850 ATP binding site [chemical binding]; other site 869816003851 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869816003852 active site 869816003853 putative metal-binding site [ion binding]; other site 869816003854 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869816003855 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 869816003856 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869816003857 CAP-like domain; other site 869816003858 active site 869816003859 primary dimer interface [polypeptide binding]; other site 869816003860 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869816003861 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 869816003862 amino acid carrier protein; Region: agcS; TIGR00835 869816003863 CAT RNA binding domain; Region: CAT_RBD; smart01061 869816003864 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869816003865 PRD domain; Region: PRD; pfam00874 869816003866 PRD domain; Region: PRD; pfam00874 869816003867 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869816003868 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869816003869 Predicted integral membrane protein [Function unknown]; Region: COG0392 869816003870 Uncharacterized conserved protein [Function unknown]; Region: COG2898 869816003871 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 869816003872 methionine sulfoxide reductase A; Provisional; Region: PRK14054 869816003873 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869816003874 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 869816003875 active site 1 [active] 869816003876 dimer interface [polypeptide binding]; other site 869816003877 hexamer interface [polypeptide binding]; other site 869816003878 active site 2 [active] 869816003879 prephenate dehydrogenase; Validated; Region: PRK06545 869816003880 prephenate dehydrogenase; Validated; Region: PRK08507 869816003881 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 869816003882 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869816003883 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 869816003884 putative oligomer interface [polypeptide binding]; other site 869816003885 putative active site [active] 869816003886 metal binding site [ion binding]; metal-binding site 869816003887 anthranilate synthase component I; Provisional; Region: PRK13567 869816003888 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 869816003889 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869816003890 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 869816003891 Glutamine amidotransferase class-I; Region: GATase; pfam00117 869816003892 glutamine binding [chemical binding]; other site 869816003893 catalytic triad [active] 869816003894 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 869816003895 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869816003896 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 869816003897 active site 869816003898 ribulose/triose binding site [chemical binding]; other site 869816003899 phosphate binding site [ion binding]; other site 869816003900 substrate (anthranilate) binding pocket [chemical binding]; other site 869816003901 product (indole) binding pocket [chemical binding]; other site 869816003902 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 869816003903 active site 869816003904 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 869816003905 substrate binding site [chemical binding]; other site 869816003906 active site 869816003907 catalytic residues [active] 869816003908 heterodimer interface [polypeptide binding]; other site 869816003909 FemAB family; Region: FemAB; pfam02388 869816003910 FemAB family; Region: FemAB; pfam02388 869816003911 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 869816003912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816003913 active site 869816003914 motif I; other site 869816003915 motif II; other site 869816003916 SWIM zinc finger; Region: SWIM; pfam04434 869816003917 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869816003918 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869816003919 Walker A/P-loop; other site 869816003920 ATP binding site [chemical binding]; other site 869816003921 Q-loop/lid; other site 869816003922 ABC transporter signature motif; other site 869816003923 Walker B; other site 869816003924 D-loop; other site 869816003925 H-loop/switch region; other site 869816003926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869816003927 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 869816003928 Walker A/P-loop; other site 869816003929 ATP binding site [chemical binding]; other site 869816003930 Q-loop/lid; other site 869816003931 ABC transporter signature motif; other site 869816003932 Walker B; other site 869816003933 D-loop; other site 869816003934 H-loop/switch region; other site 869816003935 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 869816003936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816003937 dimer interface [polypeptide binding]; other site 869816003938 conserved gate region; other site 869816003939 putative PBP binding loops; other site 869816003940 ABC-ATPase subunit interface; other site 869816003941 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869816003942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869816003943 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 869816003944 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 869816003945 oligoendopeptidase F; Region: pepF; TIGR00181 869816003946 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 869816003947 active site 869816003948 Zn binding site [ion binding]; other site 869816003949 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 869816003950 PhoU domain; Region: PhoU; pfam01895 869816003951 PhoU domain; Region: PhoU; pfam01895 869816003952 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 869816003953 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869816003954 Walker A/P-loop; other site 869816003955 ATP binding site [chemical binding]; other site 869816003956 Q-loop/lid; other site 869816003957 ABC transporter signature motif; other site 869816003958 Walker B; other site 869816003959 D-loop; other site 869816003960 H-loop/switch region; other site 869816003961 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 869816003962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816003963 dimer interface [polypeptide binding]; other site 869816003964 conserved gate region; other site 869816003965 putative PBP binding loops; other site 869816003966 ABC-ATPase subunit interface; other site 869816003967 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 869816003968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816003969 dimer interface [polypeptide binding]; other site 869816003970 conserved gate region; other site 869816003971 ABC-ATPase subunit interface; other site 869816003972 phosphate binding protein; Region: ptsS_2; TIGR02136 869816003973 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 869816003974 S1 domain; Region: S1_2; pfam13509 869816003975 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 869816003976 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869816003977 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869816003978 ABC transporter; Region: ABC_tran_2; pfam12848 869816003979 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869816003980 aspartate kinase; Reviewed; Region: PRK06635 869816003981 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 869816003982 putative nucleotide binding site [chemical binding]; other site 869816003983 putative catalytic residues [active] 869816003984 putative Mg ion binding site [ion binding]; other site 869816003985 putative aspartate binding site [chemical binding]; other site 869816003986 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 869816003987 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 869816003988 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 869816003989 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869816003990 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869816003991 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869816003992 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 869816003993 dimer interface [polypeptide binding]; other site 869816003994 active site 869816003995 catalytic residue [active] 869816003996 dihydrodipicolinate reductase; Provisional; Region: PRK00048 869816003997 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 869816003998 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 869816003999 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 869816004000 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 869816004001 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 869816004002 active site 869816004003 trimer interface [polypeptide binding]; other site 869816004004 substrate binding site [chemical binding]; other site 869816004005 CoA binding site [chemical binding]; other site 869816004006 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 869816004007 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 869816004008 metal binding site [ion binding]; metal-binding site 869816004009 dimer interface [polypeptide binding]; other site 869816004010 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 869816004011 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 869816004012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869816004013 catalytic residue [active] 869816004014 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 869816004015 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 869816004016 active site 869816004017 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869816004018 substrate binding site [chemical binding]; other site 869816004019 catalytic residues [active] 869816004020 dimer interface [polypeptide binding]; other site 869816004021 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 869816004022 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 869816004023 DNA-binding site [nucleotide binding]; DNA binding site 869816004024 RNA-binding motif; other site 869816004025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 869816004026 acylphosphatase; Provisional; Region: PRK14431 869816004027 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 869816004028 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 869816004029 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 869816004030 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 869816004031 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 869816004032 metal ion-dependent adhesion site (MIDAS); other site 869816004033 MoxR-like ATPases [General function prediction only]; Region: COG0714 869816004034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816004035 Walker A motif; other site 869816004036 ATP binding site [chemical binding]; other site 869816004037 Walker B motif; other site 869816004038 arginine finger; other site 869816004039 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869816004040 active site 869816004041 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869816004042 active site 869816004043 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 869816004044 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869816004045 E3 interaction surface; other site 869816004046 lipoyl attachment site [posttranslational modification]; other site 869816004047 e3 binding domain; Region: E3_binding; pfam02817 869816004048 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869816004049 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 869816004050 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 869816004051 TPP-binding site [chemical binding]; other site 869816004052 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 869816004053 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 869816004054 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869816004055 HAMP domain; Region: HAMP; pfam00672 869816004056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869816004057 dimer interface [polypeptide binding]; other site 869816004058 phosphorylation site [posttranslational modification] 869816004059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816004060 ATP binding site [chemical binding]; other site 869816004061 Mg2+ binding site [ion binding]; other site 869816004062 G-X-G motif; other site 869816004063 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869816004064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816004065 active site 869816004066 phosphorylation site [posttranslational modification] 869816004067 intermolecular recognition site; other site 869816004068 dimerization interface [polypeptide binding]; other site 869816004069 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869816004070 DNA binding site [nucleotide binding] 869816004071 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869816004072 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 869816004073 active site 869816004074 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 869816004075 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 869816004076 active site 869816004077 homodimer interface [polypeptide binding]; other site 869816004078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816004079 Coenzyme A binding pocket [chemical binding]; other site 869816004080 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 869816004081 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 869816004082 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 869816004083 protein binding site [polypeptide binding]; other site 869816004084 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 869816004085 Catalytic dyad [active] 869816004086 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 869816004087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 869816004088 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 869816004089 HPr interaction site; other site 869816004090 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869816004091 active site 869816004092 phosphorylation site [posttranslational modification] 869816004093 methionine sulfoxide reductase B; Provisional; Region: PRK00222 869816004094 SelR domain; Region: SelR; pfam01641 869816004095 methionine sulfoxide reductase A; Provisional; Region: PRK13014 869816004096 EDD domain protein, DegV family; Region: DegV; TIGR00762 869816004097 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869816004098 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 869816004099 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 869816004100 folate binding site [chemical binding]; other site 869816004101 NADP+ binding site [chemical binding]; other site 869816004102 thymidylate synthase; Region: thym_sym; TIGR03284 869816004103 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 869816004104 dimerization interface [polypeptide binding]; other site 869816004105 active site 869816004106 Disulphide isomerase; Region: Disulph_isomer; cl05813 869816004107 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 869816004108 Virulence factor; Region: Virulence_fact; pfam13769 869816004109 HEAT repeats; Region: HEAT_2; pfam13646 869816004110 HEAT repeat; Region: HEAT; pfam02985 869816004111 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 869816004112 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 869816004113 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 869816004114 RNA/DNA hybrid binding site [nucleotide binding]; other site 869816004115 active site 869816004116 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816004117 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 869816004118 GA module; Region: GA; smart00844 869816004119 GA module; Region: GA; smart00844 869816004120 GA module; Region: GA; smart00844 869816004121 GA module; Region: GA; smart00844 869816004122 GA module; Region: GA; smart00844 869816004123 GA module; Region: GA; smart00844 869816004124 GA module; Region: GA; smart00844 869816004125 GA module; Region: GA; smart00844 869816004126 GA module; Region: GA; smart00844 869816004127 GA module; Region: GA; smart00844 869816004128 GA module; Region: GA; smart00844 869816004129 GA module; Region: GA; smart00844 869816004130 GA module; Region: GA; smart00844 869816004131 GA module; Region: GA; smart00844 869816004132 GA module; Region: GA; smart00844 869816004133 GA module; Region: GA; smart00844 869816004134 GA module; Region: GA; smart00844 869816004135 GA module; Region: GA; smart00844 869816004136 GA module; Region: GA; smart00844 869816004137 GA module; Region: GA; smart00844 869816004138 GA module; Region: GA; smart00844 869816004139 GA module; Region: GA; smart00844 869816004140 GA module; Region: GA; smart00844 869816004141 GA module; Region: GA; smart00844 869816004142 GA module; Region: GA; smart00844 869816004143 GA module; Region: GA; smart00844 869816004144 GA module; Region: GA; smart00844 869816004145 GA module; Region: GA; smart00844 869816004146 GA module; Region: GA; smart00844 869816004147 GA module; Region: GA; smart00844 869816004148 GA module; Region: GA; smart00844 869816004149 GA module; Region: GA; smart00844 869816004150 GA module; Region: GA; smart00844 869816004151 GA module; Region: GA; smart00844 869816004152 GA module; Region: GA; smart00844 869816004153 GA module; Region: GA; smart00844 869816004154 GA module; Region: GA; smart00844 869816004155 GA module; Region: GA; smart00844 869816004156 GA module; Region: GA; smart00844 869816004157 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 869816004158 GA module; Region: GA; smart00844 869816004159 GA module; Region: GA; smart00844 869816004160 GA module; Region: GA; smart00844 869816004161 GA module; Region: GA; smart00844 869816004162 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816004163 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816004164 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816004165 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816004166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816004167 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 869816004168 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 869816004169 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 869816004170 tetramer interface [polypeptide binding]; other site 869816004171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816004172 catalytic residue [active] 869816004173 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 869816004174 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 869816004175 hexamer interface [polypeptide binding]; other site 869816004176 ligand binding site [chemical binding]; other site 869816004177 putative active site [active] 869816004178 NAD(P) binding site [chemical binding]; other site 869816004179 5'-3' exonuclease; Region: 53EXOc; smart00475 869816004180 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 869816004181 active site 869816004182 metal binding site 1 [ion binding]; metal-binding site 869816004183 putative 5' ssDNA interaction site; other site 869816004184 metal binding site 3; metal-binding site 869816004185 metal binding site 2 [ion binding]; metal-binding site 869816004186 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 869816004187 putative DNA binding site [nucleotide binding]; other site 869816004188 putative metal binding site [ion binding]; other site 869816004189 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 869816004190 Dynamin family; Region: Dynamin_N; pfam00350 869816004191 G1 box; other site 869816004192 GTP/Mg2+ binding site [chemical binding]; other site 869816004193 G2 box; other site 869816004194 Switch I region; other site 869816004195 G3 box; other site 869816004196 Switch II region; other site 869816004197 G4 box; other site 869816004198 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869816004199 Dynamin family; Region: Dynamin_N; pfam00350 869816004200 G1 box; other site 869816004201 GTP/Mg2+ binding site [chemical binding]; other site 869816004202 G2 box; other site 869816004203 Switch I region; other site 869816004204 G3 box; other site 869816004205 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869816004206 G3 box; other site 869816004207 Switch II region; other site 869816004208 GTP/Mg2+ binding site [chemical binding]; other site 869816004209 G4 box; other site 869816004210 G5 box; other site 869816004211 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 869816004212 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 869816004213 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 869816004214 Cobalt transport protein component CbiN; Region: CbiN; cl00842 869816004215 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 869816004216 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 869816004217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869816004218 cell division protein GpsB; Provisional; Region: PRK14127 869816004219 DivIVA domain; Region: DivI1A_domain; TIGR03544 869816004220 hypothetical protein; Provisional; Region: PRK13660 869816004221 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 869816004222 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 869816004223 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 869816004224 Transglycosylase; Region: Transgly; pfam00912 869816004225 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869816004226 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 869816004227 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869816004228 minor groove reading motif; other site 869816004229 helix-hairpin-helix signature motif; other site 869816004230 substrate binding pocket [chemical binding]; other site 869816004231 active site 869816004232 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 869816004233 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 869816004234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 869816004235 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 869816004236 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 869816004237 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 869816004238 putative dimer interface [polypeptide binding]; other site 869816004239 putative anticodon binding site; other site 869816004240 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 869816004241 homodimer interface [polypeptide binding]; other site 869816004242 motif 1; other site 869816004243 motif 2; other site 869816004244 active site 869816004245 motif 3; other site 869816004246 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 869816004247 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869816004248 active site 869816004249 catalytic site [active] 869816004250 substrate binding site [chemical binding]; other site 869816004251 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 869816004252 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 869816004253 Biotin operon repressor [Transcription]; Region: BirA; COG1654 869816004254 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 869816004255 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 869816004256 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 869816004257 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 869816004258 active site 869816004259 NTP binding site [chemical binding]; other site 869816004260 metal binding triad [ion binding]; metal-binding site 869816004261 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 869816004262 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 869816004263 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 869816004264 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 869816004265 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 869816004266 homodimer interface [polypeptide binding]; other site 869816004267 metal binding site [ion binding]; metal-binding site 869816004268 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 869816004269 Predicted membrane protein [Function unknown]; Region: COG4347 869816004270 Uncharacterized conserved protein [Function unknown]; Region: COG5582 869816004271 UPF0302 domain; Region: UPF0302; pfam08864 869816004272 A short protein domain of unknown function; Region: IDEAL; smart00914 869816004273 TPR repeat; Region: TPR_11; pfam13414 869816004274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869816004275 binding surface 869816004276 TPR motif; other site 869816004277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869816004278 TPR motif; other site 869816004279 binding surface 869816004280 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 869816004281 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 869816004282 hinge; other site 869816004283 active site 869816004284 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 869816004285 active site 869816004286 NAD binding site [chemical binding]; other site 869816004287 metal binding site [ion binding]; metal-binding site 869816004288 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 869816004289 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 869816004290 Tetramer interface [polypeptide binding]; other site 869816004291 active site 869816004292 FMN-binding site [chemical binding]; other site 869816004293 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 869816004294 active site 869816004295 multimer interface [polypeptide binding]; other site 869816004296 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869816004297 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869816004298 substrate binding pocket [chemical binding]; other site 869816004299 chain length determination region; other site 869816004300 substrate-Mg2+ binding site; other site 869816004301 catalytic residues [active] 869816004302 aspartate-rich region 1; other site 869816004303 active site lid residues [active] 869816004304 aspartate-rich region 2; other site 869816004305 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 869816004306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816004307 S-adenosylmethionine binding site [chemical binding]; other site 869816004308 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 869816004309 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869816004310 IHF dimer interface [polypeptide binding]; other site 869816004311 IHF - DNA interface [nucleotide binding]; other site 869816004312 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 869816004313 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869816004314 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 869816004315 GTP-binding protein Der; Reviewed; Region: PRK00093 869816004316 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 869816004317 G1 box; other site 869816004318 GTP/Mg2+ binding site [chemical binding]; other site 869816004319 Switch I region; other site 869816004320 G2 box; other site 869816004321 Switch II region; other site 869816004322 G3 box; other site 869816004323 G4 box; other site 869816004324 G5 box; other site 869816004325 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 869816004326 G1 box; other site 869816004327 GTP/Mg2+ binding site [chemical binding]; other site 869816004328 Switch I region; other site 869816004329 G2 box; other site 869816004330 G3 box; other site 869816004331 Switch II region; other site 869816004332 G4 box; other site 869816004333 G5 box; other site 869816004334 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 869816004335 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 869816004336 RNA binding site [nucleotide binding]; other site 869816004337 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 869816004338 RNA binding site [nucleotide binding]; other site 869816004339 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 869816004340 RNA binding site [nucleotide binding]; other site 869816004341 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 869816004342 RNA binding site [nucleotide binding]; other site 869816004343 cytidylate kinase; Provisional; Region: cmk; PRK00023 869816004344 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 869816004345 CMP-binding site; other site 869816004346 The sites determining sugar specificity; other site 869816004347 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 869816004348 active site 869816004349 homotetramer interface [polypeptide binding]; other site 869816004350 homodimer interface [polypeptide binding]; other site 869816004351 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 869816004352 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 869816004353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816004354 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869816004355 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 869816004356 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816004357 ATP binding site [chemical binding]; other site 869816004358 putative Mg++ binding site [ion binding]; other site 869816004359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869816004360 nucleotide binding region [chemical binding]; other site 869816004361 ATP-binding site [chemical binding]; other site 869816004362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 869816004363 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 869816004364 Predicted membrane protein [Function unknown]; Region: COG3601 869816004365 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 869816004366 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 869816004367 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 869816004368 beta-channel forming cytolysin; Region: hlyII; TIGR01002 869816004369 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 869816004370 CHAP domain; Region: CHAP; pfam05257 869816004371 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 869816004372 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 869816004373 active site 869816004374 metal binding site [ion binding]; metal-binding site 869816004375 Bacterial SH3 domain; Region: SH3_5; pfam08460 869816004376 holin, SPP1 family; Region: holin_SPP1; TIGR01592 869816004377 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 869816004378 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 869816004379 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 869816004380 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 869816004381 hypothetical protein; Provisional; Region: PRK05926 869816004382 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 869816004383 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 869816004384 Phage tail protein; Region: Sipho_tail; pfam05709 869816004385 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 869816004386 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 869816004387 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 869816004388 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 869816004389 oligomerization interface [polypeptide binding]; other site 869816004390 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 869816004391 Phage capsid family; Region: Phage_capsid; pfam05065 869816004392 Clp protease; Region: CLP_protease; pfam00574 869816004393 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 869816004394 oligomer interface [polypeptide binding]; other site 869816004395 active site residues [active] 869816004396 Phage-related protein [Function unknown]; Region: COG4695; cl01923 869816004397 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 869816004398 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 869816004399 Phage terminase, small subunit; Region: Terminase_4; pfam05119 869816004400 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 869816004401 HNH endonuclease; Region: HNH; pfam01844 869816004402 active site 869816004403 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 869816004404 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 869816004405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816004406 ATP binding site [chemical binding]; other site 869816004407 putative Mg++ binding site [ion binding]; other site 869816004408 helicase superfamily c-terminal domain; Region: HELICc; smart00490 869816004409 VRR-NUC domain; Region: VRR_NUC; pfam08774 869816004410 Virulence-associated protein E; Region: VirE; pfam05272 869816004411 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 869816004412 Transcriptional activator RinB; Region: RinB; pfam06116 869816004413 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 869816004414 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 869816004415 dUTPase; Region: dUTPase_2; pfam08761 869816004416 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 869816004417 active site 869816004418 homodimer interface [polypeptide binding]; other site 869816004419 metal binding site [ion binding]; metal-binding site 869816004420 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 869816004421 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 869816004422 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 869816004423 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 869816004424 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 869816004425 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 869816004426 active site 869816004427 DNA binding site [nucleotide binding] 869816004428 catalytic site [active] 869816004429 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 869816004430 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 869816004431 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 869816004432 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 869816004433 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 869816004434 Homeodomain-like domain; Region: HTH_23; pfam13384 869816004435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816004436 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869816004437 non-specific DNA binding site [nucleotide binding]; other site 869816004438 salt bridge; other site 869816004439 sequence-specific DNA binding site [nucleotide binding]; other site 869816004440 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869816004441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816004442 non-specific DNA binding site [nucleotide binding]; other site 869816004443 salt bridge; other site 869816004444 sequence-specific DNA binding site [nucleotide binding]; other site 869816004445 Domain of unknown function (DUF955); Region: DUF955; pfam06114 869816004446 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 869816004447 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 869816004448 Int/Topo IB signature motif; other site 869816004449 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 869816004450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869816004451 dimerization interface [polypeptide binding]; other site 869816004452 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 869816004453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869816004454 dimer interface [polypeptide binding]; other site 869816004455 phosphorylation site [posttranslational modification] 869816004456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816004457 ATP binding site [chemical binding]; other site 869816004458 Mg2+ binding site [ion binding]; other site 869816004459 G-X-G motif; other site 869816004460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869816004461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816004462 active site 869816004463 phosphorylation site [posttranslational modification] 869816004464 intermolecular recognition site; other site 869816004465 dimerization interface [polypeptide binding]; other site 869816004466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869816004467 DNA binding site [nucleotide binding] 869816004468 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869816004469 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869816004470 RNA binding surface [nucleotide binding]; other site 869816004471 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 869816004472 active site 869816004473 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 869816004474 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 869816004475 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 869816004476 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 869816004477 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 869816004478 active site 869816004479 Int/Topo IB signature motif; other site 869816004480 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 869816004481 metal binding site 2 [ion binding]; metal-binding site 869816004482 putative DNA binding helix; other site 869816004483 metal binding site 1 [ion binding]; metal-binding site 869816004484 dimer interface [polypeptide binding]; other site 869816004485 structural Zn2+ binding site [ion binding]; other site 869816004486 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 869816004487 dimer interface [polypeptide binding]; other site 869816004488 ADP-ribose binding site [chemical binding]; other site 869816004489 active site 869816004490 nudix motif; other site 869816004491 metal binding site [ion binding]; metal-binding site 869816004492 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869816004493 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869816004494 active site 869816004495 catalytic tetrad [active] 869816004496 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 869816004497 classical (c) SDRs; Region: SDR_c; cd05233 869816004498 NAD(P) binding site [chemical binding]; other site 869816004499 active site 869816004500 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 869816004501 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 869816004502 ribonuclease Z; Region: RNase_Z; TIGR02651 869816004503 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 869816004504 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 869816004505 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 869816004506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869816004507 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 869816004508 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869816004509 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869816004510 Ca binding site [ion binding]; other site 869816004511 active site 869816004512 catalytic site [active] 869816004513 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869816004514 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869816004515 DNA binding site [nucleotide binding] 869816004516 domain linker motif; other site 869816004517 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 869816004518 putative ligand binding site [chemical binding]; other site 869816004519 putative dimerization interface [polypeptide binding]; other site 869816004520 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869816004521 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 869816004522 YcaO-like family; Region: YcaO; pfam02624 869816004523 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 869816004524 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 869816004525 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 869816004526 putative FMN binding site [chemical binding]; other site 869816004527 NADPH bind site [chemical binding]; other site 869816004528 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869816004529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816004530 Walker A/P-loop; other site 869816004531 ATP binding site [chemical binding]; other site 869816004532 Q-loop/lid; other site 869816004533 ABC transporter signature motif; other site 869816004534 Walker B; other site 869816004535 D-loop; other site 869816004536 H-loop/switch region; other site 869816004537 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869816004538 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 869816004539 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 869816004540 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 869816004541 peptidase T-like protein; Region: PepT-like; TIGR01883 869816004542 metal binding site [ion binding]; metal-binding site 869816004543 putative dimer interface [polypeptide binding]; other site 869816004544 Predicted membrane protein [Function unknown]; Region: COG4129 869816004545 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 869816004546 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 869816004547 Disulphide isomerase; Region: Disulph_isomer; pfam06491 869816004548 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869816004549 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 869816004550 E3 interaction surface; other site 869816004551 lipoyl attachment site [posttranslational modification]; other site 869816004552 e3 binding domain; Region: E3_binding; pfam02817 869816004553 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869816004554 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 869816004555 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 869816004556 alpha subunit interface [polypeptide binding]; other site 869816004557 TPP binding site [chemical binding]; other site 869816004558 heterodimer interface [polypeptide binding]; other site 869816004559 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869816004560 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 869816004561 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 869816004562 tetramer interface [polypeptide binding]; other site 869816004563 TPP-binding site [chemical binding]; other site 869816004564 heterodimer interface [polypeptide binding]; other site 869816004565 phosphorylation loop region [posttranslational modification] 869816004566 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 869816004567 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 869816004568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816004569 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869816004570 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 869816004571 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869816004572 Walker A/P-loop; other site 869816004573 ATP binding site [chemical binding]; other site 869816004574 Q-loop/lid; other site 869816004575 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869816004576 ABC transporter signature motif; other site 869816004577 Walker B; other site 869816004578 D-loop; other site 869816004579 H-loop/switch region; other site 869816004580 arginine repressor; Provisional; Region: PRK04280 869816004581 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869816004582 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869816004583 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869816004584 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869816004585 substrate binding pocket [chemical binding]; other site 869816004586 chain length determination region; other site 869816004587 substrate-Mg2+ binding site; other site 869816004588 catalytic residues [active] 869816004589 aspartate-rich region 1; other site 869816004590 active site lid residues [active] 869816004591 aspartate-rich region 2; other site 869816004592 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 869816004593 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 869816004594 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 869816004595 generic binding surface II; other site 869816004596 generic binding surface I; other site 869816004597 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 869816004598 putative RNA binding site [nucleotide binding]; other site 869816004599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869816004600 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 869816004601 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869816004602 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869816004603 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 869816004604 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 869816004605 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869816004606 carboxyltransferase (CT) interaction site; other site 869816004607 biotinylation site [posttranslational modification]; other site 869816004608 elongation factor P; Validated; Region: PRK00529 869816004609 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 869816004610 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 869816004611 RNA binding site [nucleotide binding]; other site 869816004612 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 869816004613 RNA binding site [nucleotide binding]; other site 869816004614 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869816004615 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869816004616 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869816004617 active site 869816004618 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 869816004619 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 869816004620 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869816004621 active site residue [active] 869816004622 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 869816004623 tetramer interface [polypeptide binding]; other site 869816004624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816004625 catalytic residue [active] 869816004626 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 869816004627 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 869816004628 tetramer interface [polypeptide binding]; other site 869816004629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816004630 catalytic residue [active] 869816004631 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 869816004632 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 869816004633 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 869816004634 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 869816004635 ADP binding site [chemical binding]; other site 869816004636 magnesium binding site [ion binding]; other site 869816004637 putative shikimate binding site; other site 869816004638 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 869816004639 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 869816004640 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 869816004641 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 869816004642 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 869816004643 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869816004644 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869816004645 Type II/IV secretion system protein; Region: T2SE; pfam00437 869816004646 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869816004647 Walker A motif; other site 869816004648 ATP binding site [chemical binding]; other site 869816004649 Walker B motif; other site 869816004650 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869816004651 Uncharacterized conserved protein [Function unknown]; Region: COG0011 869816004652 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 869816004653 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869816004654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 869816004655 Rhomboid family; Region: Rhomboid; pfam01694 869816004656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869816004657 binding surface 869816004658 TPR motif; other site 869816004659 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869816004660 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 869816004661 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 869816004662 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 869816004663 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869816004664 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869816004665 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869816004666 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 869816004667 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 869816004668 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 869816004669 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 869816004670 metal binding site 2 [ion binding]; metal-binding site 869816004671 putative DNA binding helix; other site 869816004672 metal binding site 1 [ion binding]; metal-binding site 869816004673 dimer interface [polypeptide binding]; other site 869816004674 structural Zn2+ binding site [ion binding]; other site 869816004675 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869816004676 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816004677 ABC-ATPase subunit interface; other site 869816004678 dimer interface [polypeptide binding]; other site 869816004679 putative PBP binding regions; other site 869816004680 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869816004681 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869816004682 endonuclease IV; Provisional; Region: PRK01060 869816004683 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 869816004684 AP (apurinic/apyrimidinic) site pocket; other site 869816004685 DNA interaction; other site 869816004686 Metal-binding active site; metal-binding site 869816004687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869816004688 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869816004689 ATP binding site [chemical binding]; other site 869816004690 putative Mg++ binding site [ion binding]; other site 869816004691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869816004692 nucleotide binding region [chemical binding]; other site 869816004693 ATP-binding site [chemical binding]; other site 869816004694 Uncharacterized conserved protein [Function unknown]; Region: COG0327 869816004695 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 869816004696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 869816004697 Uncharacterized conserved protein [Function unknown]; Region: COG0327 869816004698 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 869816004699 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 869816004700 Family of unknown function (DUF633); Region: DUF633; pfam04816 869816004701 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 869816004702 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 869816004703 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869816004704 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869816004705 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869816004706 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869816004707 DNA binding residues [nucleotide binding] 869816004708 DNA primase, catalytic core; Region: dnaG; TIGR01391 869816004709 CHC2 zinc finger; Region: zf-CHC2; pfam01807 869816004710 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 869816004711 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 869816004712 active site 869816004713 metal binding site [ion binding]; metal-binding site 869816004714 interdomain interaction site; other site 869816004715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 869816004716 HTH domain; Region: HTH_11; cl17392 869816004717 FOG: CBS domain [General function prediction only]; Region: COG0517 869816004718 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 869816004719 glycyl-tRNA synthetase; Provisional; Region: PRK04173 869816004720 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869816004721 motif 1; other site 869816004722 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 869816004723 active site 869816004724 motif 2; other site 869816004725 motif 3; other site 869816004726 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 869816004727 anticodon binding site; other site 869816004728 DNA repair protein RecO; Region: reco; TIGR00613 869816004729 Recombination protein O N terminal; Region: RecO_N; pfam11967 869816004730 Recombination protein O C terminal; Region: RecO_C; pfam02565 869816004731 GTPase Era; Reviewed; Region: era; PRK00089 869816004732 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 869816004733 G1 box; other site 869816004734 GTP/Mg2+ binding site [chemical binding]; other site 869816004735 Switch I region; other site 869816004736 G2 box; other site 869816004737 Switch II region; other site 869816004738 G3 box; other site 869816004739 G4 box; other site 869816004740 G5 box; other site 869816004741 KH domain; Region: KH_2; pfam07650 869816004742 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869816004743 active site 869816004744 catalytic motif [active] 869816004745 Zn binding site [ion binding]; other site 869816004746 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 869816004747 metal-binding heat shock protein; Provisional; Region: PRK00016 869816004748 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 869816004749 PhoH-like protein; Region: PhoH; pfam02562 869816004750 hypothetical protein; Provisional; Region: PRK13665 869816004751 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 869816004752 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 869816004753 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 869816004754 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 869816004755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869816004756 FeS/SAM binding site; other site 869816004757 TRAM domain; Region: TRAM; cl01282 869816004758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 869816004759 RNA methyltransferase, RsmE family; Region: TIGR00046 869816004760 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 869816004761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816004762 S-adenosylmethionine binding site [chemical binding]; other site 869816004763 chaperone protein DnaJ; Provisional; Region: PRK14280 869816004764 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869816004765 HSP70 interaction site [polypeptide binding]; other site 869816004766 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 869816004767 substrate binding site [polypeptide binding]; other site 869816004768 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 869816004769 Zn binding sites [ion binding]; other site 869816004770 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 869816004771 dimer interface [polypeptide binding]; other site 869816004772 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 869816004773 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 869816004774 nucleotide binding site [chemical binding]; other site 869816004775 NEF interaction site [polypeptide binding]; other site 869816004776 SBD interface [polypeptide binding]; other site 869816004777 heat shock protein GrpE; Provisional; Region: PRK14140 869816004778 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 869816004779 dimer interface [polypeptide binding]; other site 869816004780 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 869816004781 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 869816004782 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 869816004783 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 869816004784 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 869816004785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869816004786 FeS/SAM binding site; other site 869816004787 HemN C-terminal domain; Region: HemN_C; pfam06969 869816004788 GTP-binding protein LepA; Provisional; Region: PRK05433 869816004789 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 869816004790 G1 box; other site 869816004791 putative GEF interaction site [polypeptide binding]; other site 869816004792 GTP/Mg2+ binding site [chemical binding]; other site 869816004793 Switch I region; other site 869816004794 G2 box; other site 869816004795 G3 box; other site 869816004796 Switch II region; other site 869816004797 G4 box; other site 869816004798 G5 box; other site 869816004799 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 869816004800 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 869816004801 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 869816004802 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 869816004803 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 869816004804 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 869816004805 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 869816004806 Competence protein; Region: Competence; pfam03772 869816004807 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 869816004808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869816004809 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 869816004810 catalytic motif [active] 869816004811 Zn binding site [ion binding]; other site 869816004812 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 869816004813 Helix-hairpin-helix motif; Region: HHH; pfam00633 869816004814 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869816004815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816004816 S-adenosylmethionine binding site [chemical binding]; other site 869816004817 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 869816004818 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869816004819 Zn2+ binding site [ion binding]; other site 869816004820 Mg2+ binding site [ion binding]; other site 869816004821 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 869816004822 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 869816004823 active site 869816004824 (T/H)XGH motif; other site 869816004825 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 869816004826 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 869816004827 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 869816004828 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 869816004829 shikimate binding site; other site 869816004830 NAD(P) binding site [chemical binding]; other site 869816004831 GTPase YqeH; Provisional; Region: PRK13796 869816004832 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 869816004833 GTP/Mg2+ binding site [chemical binding]; other site 869816004834 G4 box; other site 869816004835 G5 box; other site 869816004836 G1 box; other site 869816004837 Switch I region; other site 869816004838 G2 box; other site 869816004839 G3 box; other site 869816004840 Switch II region; other site 869816004841 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 869816004842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816004843 active site 869816004844 motif I; other site 869816004845 motif II; other site 869816004846 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 869816004847 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 869816004848 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 869816004849 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 869816004850 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 869816004851 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 869816004852 putative active site [active] 869816004853 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 869816004854 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869816004855 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869816004856 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 869816004857 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 869816004858 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869816004859 carboxyltransferase (CT) interaction site; other site 869816004860 biotinylation site [posttranslational modification]; other site 869816004861 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 869816004862 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 869816004863 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 869816004864 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 869816004865 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 869816004866 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 869816004867 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 869816004868 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 869816004869 Sugar specificity; other site 869816004870 Pyrimidine base specificity; other site 869816004871 ATP-binding site [chemical binding]; other site 869816004872 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869816004873 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869816004874 Peptidase family U32; Region: Peptidase_U32; pfam01136 869816004875 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869816004876 Peptidase family U32; Region: Peptidase_U32; pfam01136 869816004877 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 869816004878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816004879 S-adenosylmethionine binding site [chemical binding]; other site 869816004880 hypothetical protein; Provisional; Region: PRK13678 869816004881 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 869816004882 hypothetical protein; Provisional; Region: PRK05473 869816004883 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 869816004884 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 869816004885 motif 1; other site 869816004886 active site 869816004887 motif 2; other site 869816004888 motif 3; other site 869816004889 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869816004890 DHHA1 domain; Region: DHHA1; pfam02272 869816004891 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 869816004892 AAA domain; Region: AAA_30; pfam13604 869816004893 Family description; Region: UvrD_C_2; pfam13538 869816004894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869816004895 binding surface 869816004896 TPR motif; other site 869816004897 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 869816004898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869816004899 binding surface 869816004900 TPR motif; other site 869816004901 TPR repeat; Region: TPR_11; pfam13414 869816004902 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 869816004903 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 869816004904 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869816004905 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869816004906 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869816004907 catalytic residue [active] 869816004908 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 869816004909 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 869816004910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 869816004911 Predicted transcriptional regulator [Transcription]; Region: COG1959 869816004912 Transcriptional regulator; Region: Rrf2; pfam02082 869816004913 recombination factor protein RarA; Reviewed; Region: PRK13342 869816004914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816004915 Walker A motif; other site 869816004916 ATP binding site [chemical binding]; other site 869816004917 Walker B motif; other site 869816004918 arginine finger; other site 869816004919 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 869816004920 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 869816004921 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 869816004922 putative ATP binding site [chemical binding]; other site 869816004923 putative substrate interface [chemical binding]; other site 869816004924 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 869816004925 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 869816004926 dimer interface [polypeptide binding]; other site 869816004927 anticodon binding site; other site 869816004928 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869816004929 homodimer interface [polypeptide binding]; other site 869816004930 motif 1; other site 869816004931 active site 869816004932 motif 2; other site 869816004933 GAD domain; Region: GAD; pfam02938 869816004934 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869816004935 motif 3; other site 869816004936 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 869816004937 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 869816004938 dimer interface [polypeptide binding]; other site 869816004939 motif 1; other site 869816004940 active site 869816004941 motif 2; other site 869816004942 motif 3; other site 869816004943 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 869816004944 anticodon binding site; other site 869816004945 Bacterial SH3 domain homologues; Region: SH3b; smart00287 869816004946 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 869816004947 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 869816004948 active site 869816004949 metal binding site [ion binding]; metal-binding site 869816004950 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 869816004951 putative active site [active] 869816004952 dimerization interface [polypeptide binding]; other site 869816004953 putative tRNAtyr binding site [nucleotide binding]; other site 869816004954 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 869816004955 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869816004956 Zn2+ binding site [ion binding]; other site 869816004957 Mg2+ binding site [ion binding]; other site 869816004958 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869816004959 synthetase active site [active] 869816004960 NTP binding site [chemical binding]; other site 869816004961 metal binding site [ion binding]; metal-binding site 869816004962 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 869816004963 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 869816004964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869816004965 active site 869816004966 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 869816004967 DHH family; Region: DHH; pfam01368 869816004968 DHHA1 domain; Region: DHHA1; pfam02272 869816004969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 869816004970 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 869816004971 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 869816004972 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 869816004973 Protein export membrane protein; Region: SecD_SecF; pfam02355 869816004974 Preprotein translocase subunit; Region: YajC; pfam02699 869816004975 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 869816004976 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 869816004977 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 869816004978 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 869816004979 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 869816004980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816004981 Walker A motif; other site 869816004982 ATP binding site [chemical binding]; other site 869816004983 Walker B motif; other site 869816004984 arginine finger; other site 869816004985 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 869816004986 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 869816004987 RuvA N terminal domain; Region: RuvA_N; pfam01330 869816004988 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 869816004989 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 869816004990 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 869816004991 GTPase CgtA; Reviewed; Region: obgE; PRK12297 869816004992 GTP1/OBG; Region: GTP1_OBG; pfam01018 869816004993 Obg GTPase; Region: Obg; cd01898 869816004994 G1 box; other site 869816004995 GTP/Mg2+ binding site [chemical binding]; other site 869816004996 Switch I region; other site 869816004997 G2 box; other site 869816004998 G3 box; other site 869816004999 Switch II region; other site 869816005000 G4 box; other site 869816005001 G5 box; other site 869816005002 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 869816005003 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 869816005004 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 869816005005 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 869816005006 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 869816005007 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 869816005008 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 869816005009 rod shape-determining protein MreC; Region: MreC; pfam04085 869816005010 hypothetical protein; Reviewed; Region: PRK00024 869816005011 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 869816005012 MPN+ (JAMM) motif; other site 869816005013 Zinc-binding site [ion binding]; other site 869816005014 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 869816005015 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 869816005016 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 869816005017 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 869816005018 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869816005019 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869816005020 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 869816005021 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869816005022 active site 869816005023 HIGH motif; other site 869816005024 nucleotide binding site [chemical binding]; other site 869816005025 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869816005026 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 869816005027 active site 869816005028 KMSKS motif; other site 869816005029 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 869816005030 tRNA binding surface [nucleotide binding]; other site 869816005031 anticodon binding site; other site 869816005032 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 869816005033 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 869816005034 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 869816005035 Putative ammonia monooxygenase; Region: AmoA; pfam05145 869816005036 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 869816005037 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 869816005038 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869816005039 inhibitor-cofactor binding pocket; inhibition site 869816005040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816005041 catalytic residue [active] 869816005042 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 869816005043 dimer interface [polypeptide binding]; other site 869816005044 active site 869816005045 Schiff base residues; other site 869816005046 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 869816005047 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 869816005048 active site 869816005049 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 869816005050 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 869816005051 domain interfaces; other site 869816005052 active site 869816005053 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 869816005054 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 869816005055 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 869816005056 tRNA; other site 869816005057 putative tRNA binding site [nucleotide binding]; other site 869816005058 putative NADP binding site [chemical binding]; other site 869816005059 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 869816005060 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 869816005061 G1 box; other site 869816005062 GTP/Mg2+ binding site [chemical binding]; other site 869816005063 Switch I region; other site 869816005064 G2 box; other site 869816005065 G3 box; other site 869816005066 Switch II region; other site 869816005067 G4 box; other site 869816005068 G5 box; other site 869816005069 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 869816005070 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 869816005071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816005072 Walker A motif; other site 869816005073 ATP binding site [chemical binding]; other site 869816005074 Walker B motif; other site 869816005075 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869816005076 trigger factor; Provisional; Region: tig; PRK01490 869816005077 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869816005078 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 869816005079 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 869816005080 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 869816005081 23S rRNA binding site [nucleotide binding]; other site 869816005082 L21 binding site [polypeptide binding]; other site 869816005083 L13 binding site [polypeptide binding]; other site 869816005084 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 869816005085 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 869816005086 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 869816005087 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 869816005088 lysine transporter; Provisional; Region: PRK10836 869816005089 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 869816005090 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 869816005091 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869816005092 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 869816005093 active site 869816005094 dimer interface [polypeptide binding]; other site 869816005095 motif 1; other site 869816005096 motif 2; other site 869816005097 motif 3; other site 869816005098 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 869816005099 anticodon binding site; other site 869816005100 primosomal protein DnaI; Reviewed; Region: PRK08939 869816005101 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 869816005102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816005103 Walker A motif; other site 869816005104 ATP binding site [chemical binding]; other site 869816005105 Walker B motif; other site 869816005106 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 869816005107 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 869816005108 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 869816005109 ATP cone domain; Region: ATP-cone; pfam03477 869816005110 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 869816005111 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 869816005112 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869816005113 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 869816005114 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 869816005115 CoA-binding site [chemical binding]; other site 869816005116 ATP-binding [chemical binding]; other site 869816005117 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 869816005118 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 869816005119 DNA binding site [nucleotide binding] 869816005120 catalytic residue [active] 869816005121 H2TH interface [polypeptide binding]; other site 869816005122 putative catalytic residues [active] 869816005123 turnover-facilitating residue; other site 869816005124 intercalation triad [nucleotide binding]; other site 869816005125 8OG recognition residue [nucleotide binding]; other site 869816005126 putative reading head residues; other site 869816005127 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 869816005128 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869816005129 DNA polymerase I; Provisional; Region: PRK05755 869816005130 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 869816005131 active site 869816005132 metal binding site 1 [ion binding]; metal-binding site 869816005133 putative 5' ssDNA interaction site; other site 869816005134 metal binding site 3; metal-binding site 869816005135 metal binding site 2 [ion binding]; metal-binding site 869816005136 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 869816005137 putative DNA binding site [nucleotide binding]; other site 869816005138 putative metal binding site [ion binding]; other site 869816005139 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 869816005140 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 869816005141 active site 869816005142 DNA binding site [nucleotide binding] 869816005143 catalytic site [active] 869816005144 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 869816005145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869816005146 dimer interface [polypeptide binding]; other site 869816005147 phosphorylation site [posttranslational modification] 869816005148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816005149 ATP binding site [chemical binding]; other site 869816005150 Mg2+ binding site [ion binding]; other site 869816005151 G-X-G motif; other site 869816005152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869816005153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816005154 active site 869816005155 phosphorylation site [posttranslational modification] 869816005156 intermolecular recognition site; other site 869816005157 dimerization interface [polypeptide binding]; other site 869816005158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869816005159 DNA binding site [nucleotide binding] 869816005160 isocitrate dehydrogenase; Reviewed; Region: PRK07006 869816005161 isocitrate dehydrogenase; Validated; Region: PRK07362 869816005162 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 869816005163 dimer interface [polypeptide binding]; other site 869816005164 Citrate synthase; Region: Citrate_synt; pfam00285 869816005165 active site 869816005166 citrylCoA binding site [chemical binding]; other site 869816005167 oxalacetate/citrate binding site [chemical binding]; other site 869816005168 coenzyme A binding site [chemical binding]; other site 869816005169 catalytic triad [active] 869816005170 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 869816005171 pyruvate kinase; Provisional; Region: PRK06354 869816005172 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 869816005173 domain interfaces; other site 869816005174 active site 869816005175 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 869816005176 6-phosphofructokinase; Provisional; Region: PRK03202 869816005177 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 869816005178 active site 869816005179 ADP/pyrophosphate binding site [chemical binding]; other site 869816005180 dimerization interface [polypeptide binding]; other site 869816005181 allosteric effector site; other site 869816005182 fructose-1,6-bisphosphate binding site; other site 869816005183 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 869816005184 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 869816005185 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 869816005186 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 869816005187 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 869816005188 Malic enzyme, N-terminal domain; Region: malic; pfam00390 869816005189 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 869816005190 putative NAD(P) binding site [chemical binding]; other site 869816005191 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 869816005192 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 869816005193 active site 869816005194 PHP Thumb interface [polypeptide binding]; other site 869816005195 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 869816005196 generic binding surface I; other site 869816005197 generic binding surface II; other site 869816005198 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 869816005199 DHH family; Region: DHH; pfam01368 869816005200 DHHA1 domain; Region: DHHA1; pfam02272 869816005201 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 869816005202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 869816005203 DNA-binding site [nucleotide binding]; DNA binding site 869816005204 DRTGG domain; Region: DRTGG; pfam07085 869816005205 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 869816005206 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 869816005207 active site 2 [active] 869816005208 active site 1 [active] 869816005209 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869816005210 Ligand Binding Site [chemical binding]; other site 869816005211 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 869816005212 metal-dependent hydrolase; Provisional; Region: PRK00685 869816005213 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869816005214 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869816005215 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869816005216 active site 869816005217 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 869816005218 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 869816005219 hexamer interface [polypeptide binding]; other site 869816005220 ligand binding site [chemical binding]; other site 869816005221 putative active site [active] 869816005222 NAD(P) binding site [chemical binding]; other site 869816005223 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869816005224 Ligand Binding Site [chemical binding]; other site 869816005225 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 869816005226 propionate/acetate kinase; Provisional; Region: PRK12379 869816005227 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 869816005228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816005229 S-adenosylmethionine binding site [chemical binding]; other site 869816005230 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 869816005231 dimer interface [polypeptide binding]; other site 869816005232 catalytic triad [active] 869816005233 peroxidatic and resolving cysteines [active] 869816005234 hypothetical protein; Provisional; Region: PRK10621 869816005235 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 869816005236 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 869816005237 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 869816005238 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 869816005239 Ligand Binding Site [chemical binding]; other site 869816005240 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869816005241 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869816005242 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869816005243 catalytic residue [active] 869816005244 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 869816005245 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 869816005246 GAF domain; Region: GAF_2; pfam13185 869816005247 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 869816005248 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 869816005249 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869816005250 RNA binding surface [nucleotide binding]; other site 869816005251 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 869816005252 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 869816005253 active site 869816005254 catalytic site [active] 869816005255 OsmC-like protein; Region: OsmC; cl00767 869816005256 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 869816005257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869816005258 catalytic residue [active] 869816005259 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 869816005260 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 869816005261 ligand binding site [chemical binding]; other site 869816005262 NAD binding site [chemical binding]; other site 869816005263 dimerization interface [polypeptide binding]; other site 869816005264 catalytic site [active] 869816005265 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 869816005266 putative L-serine binding site [chemical binding]; other site 869816005267 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 869816005268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816005269 motif II; other site 869816005270 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 869816005271 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869816005272 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869816005273 active site turn [active] 869816005274 phosphorylation site [posttranslational modification] 869816005275 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 869816005276 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 869816005277 putative acyl-acceptor binding pocket; other site 869816005278 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869816005279 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869816005280 protein binding site [polypeptide binding]; other site 869816005281 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 869816005282 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 869816005283 active site 869816005284 HIGH motif; other site 869816005285 dimer interface [polypeptide binding]; other site 869816005286 KMSKS motif; other site 869816005287 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869816005288 RNA binding surface [nucleotide binding]; other site 869816005289 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 869816005290 Transglycosylase; Region: Transgly; pfam00912 869816005291 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 869816005292 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869816005293 NEAr Transporter domain; Region: NEAT; smart00725 869816005294 NEAr Transporter domain; Region: NEAT; smart00725 869816005295 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 869816005296 heme-binding site [chemical binding]; other site 869816005297 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 869816005298 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 869816005299 Potassium binding sites [ion binding]; other site 869816005300 Cesium cation binding sites [ion binding]; other site 869816005301 acetyl-CoA synthetase; Provisional; Region: PRK04319 869816005302 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 869816005303 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 869816005304 active site 869816005305 acyl-activating enzyme (AAE) consensus motif; other site 869816005306 putative CoA binding site [chemical binding]; other site 869816005307 AMP binding site [chemical binding]; other site 869816005308 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 869816005309 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 869816005310 active site 869816005311 Zn binding site [ion binding]; other site 869816005312 catabolite control protein A; Region: ccpA; TIGR01481 869816005313 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869816005314 DNA binding site [nucleotide binding] 869816005315 domain linker motif; other site 869816005316 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 869816005317 dimerization interface [polypeptide binding]; other site 869816005318 effector binding site; other site 869816005319 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 869816005320 Chorismate mutase type II; Region: CM_2; cl00693 869816005321 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 869816005322 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 869816005323 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 869816005324 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869816005325 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869816005326 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869816005327 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 869816005328 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869816005329 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 869816005330 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869816005331 putative tRNA-binding site [nucleotide binding]; other site 869816005332 hypothetical protein; Provisional; Region: PRK13668 869816005333 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869816005334 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869816005335 catalytic residues [active] 869816005336 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869816005337 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 869816005338 oligomer interface [polypeptide binding]; other site 869816005339 active site 869816005340 metal binding site [ion binding]; metal-binding site 869816005341 Predicted small secreted protein [Function unknown]; Region: COG5584 869816005342 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 869816005343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816005344 S-adenosylmethionine binding site [chemical binding]; other site 869816005345 Phosphotransferase enzyme family; Region: APH; pfam01636 869816005346 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 869816005347 active site 869816005348 substrate binding site [chemical binding]; other site 869816005349 ATP binding site [chemical binding]; other site 869816005350 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869816005351 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 869816005352 homodimer interface [polypeptide binding]; other site 869816005353 substrate-cofactor binding pocket; other site 869816005354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816005355 catalytic residue [active] 869816005356 dipeptidase PepV; Reviewed; Region: PRK07318 869816005357 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 869816005358 active site 869816005359 metal binding site [ion binding]; metal-binding site 869816005360 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869816005361 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869816005362 RNA binding surface [nucleotide binding]; other site 869816005363 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 869816005364 active site 869816005365 uracil binding [chemical binding]; other site 869816005366 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869816005367 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 869816005368 HI0933-like protein; Region: HI0933_like; pfam03486 869816005369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869816005370 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816005371 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 869816005372 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005373 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005374 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005375 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005376 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005377 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005378 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005379 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005380 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005381 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005382 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005383 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005384 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005385 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816005386 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869816005387 active site residue [active] 869816005388 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 869816005389 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869816005390 HIGH motif; other site 869816005391 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869816005392 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869816005393 active site 869816005394 KMSKS motif; other site 869816005395 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 869816005396 tRNA binding surface [nucleotide binding]; other site 869816005397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816005398 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816005399 putative substrate translocation pore; other site 869816005400 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 869816005401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816005402 S-adenosylmethionine binding site [chemical binding]; other site 869816005403 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816005404 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 869816005405 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869816005406 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 869816005407 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 869816005408 homopentamer interface [polypeptide binding]; other site 869816005409 active site 869816005410 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 869816005411 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 869816005412 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 869816005413 dimerization interface [polypeptide binding]; other site 869816005414 active site 869816005415 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 869816005416 Lumazine binding domain; Region: Lum_binding; pfam00677 869816005417 Lumazine binding domain; Region: Lum_binding; pfam00677 869816005418 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 869816005419 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 869816005420 catalytic motif [active] 869816005421 Zn binding site [ion binding]; other site 869816005422 RibD C-terminal domain; Region: RibD_C; cl17279 869816005423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 869816005424 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 869816005425 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869816005426 dimerization interface [polypeptide binding]; other site 869816005427 putative DNA binding site [nucleotide binding]; other site 869816005428 putative Zn2+ binding site [ion binding]; other site 869816005429 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 869816005430 arsenical pump membrane protein; Provisional; Region: PRK15445 869816005431 transmembrane helices; other site 869816005432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869816005433 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816005434 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869816005435 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816005436 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 869816005437 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 869816005438 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 869816005439 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 869816005440 DNA binding residues [nucleotide binding] 869816005441 CAAX protease self-immunity; Region: Abi; pfam02517 869816005442 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 869816005443 active site 869816005444 intersubunit interactions; other site 869816005445 catalytic residue [active] 869816005446 camphor resistance protein CrcB; Provisional; Region: PRK14201 869816005447 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 869816005448 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869816005449 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869816005450 active site 869816005451 catalytic tetrad [active] 869816005452 S-adenosylmethionine synthetase; Validated; Region: PRK05250 869816005453 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 869816005454 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 869816005455 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 869816005456 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 869816005457 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 869816005458 active site 869816005459 substrate-binding site [chemical binding]; other site 869816005460 metal-binding site [ion binding] 869816005461 ATP binding site [chemical binding]; other site 869816005462 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 869816005463 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 869816005464 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 869816005465 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 869816005466 nudix motif; other site 869816005467 Haemolytic domain; Region: Haemolytic; pfam01809 869816005468 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 869816005469 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 869816005470 metal binding site [ion binding]; metal-binding site 869816005471 substrate binding pocket [chemical binding]; other site 869816005472 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 869816005473 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 869816005474 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 869816005475 acyl-activating enzyme (AAE) consensus motif; other site 869816005476 putative AMP binding site [chemical binding]; other site 869816005477 putative active site [active] 869816005478 putative CoA binding site [chemical binding]; other site 869816005479 Excalibur calcium-binding domain; Region: Excalibur; smart00894 869816005480 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 869816005481 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 869816005482 Domain of unknown function (DUF955); Region: DUF955; pfam06114 869816005483 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 869816005484 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 869816005485 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 869816005486 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 869816005487 substrate binding site [chemical binding]; other site 869816005488 catalytic residues [active] 869816005489 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 869816005490 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 869816005491 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 869816005492 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 869816005493 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869816005494 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869816005495 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869816005496 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869816005497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816005498 S-adenosylmethionine binding site [chemical binding]; other site 869816005499 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 869816005500 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 869816005501 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 869816005502 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 869816005503 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 869816005504 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 869816005505 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 869816005506 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 869816005507 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 869816005508 beta-channel forming cytolysin; Region: hlyII; TIGR01002 869816005509 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 869816005510 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 869816005511 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 869816005512 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 869816005513 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 869816005514 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 869816005515 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 869816005516 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 869816005517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869816005518 ferrochelatase; Provisional; Region: PRK12435 869816005519 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 869816005520 C-terminal domain interface [polypeptide binding]; other site 869816005521 active site 869816005522 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 869816005523 active site 869816005524 N-terminal domain interface [polypeptide binding]; other site 869816005525 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 869816005526 substrate binding site [chemical binding]; other site 869816005527 active site 869816005528 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 869816005529 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 869816005530 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869816005531 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869816005532 Walker A/P-loop; other site 869816005533 ATP binding site [chemical binding]; other site 869816005534 Q-loop/lid; other site 869816005535 ABC transporter signature motif; other site 869816005536 Walker B; other site 869816005537 D-loop; other site 869816005538 H-loop/switch region; other site 869816005539 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 869816005540 HIT family signature motif; other site 869816005541 catalytic residue [active] 869816005542 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 869816005543 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 869816005544 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 869816005545 SurA N-terminal domain; Region: SurA_N_3; cl07813 869816005546 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 869816005547 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 869816005548 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 869816005549 generic binding surface II; other site 869816005550 generic binding surface I; other site 869816005551 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869816005552 Zn2+ binding site [ion binding]; other site 869816005553 Mg2+ binding site [ion binding]; other site 869816005554 Uncharacterized conserved protein [Function unknown]; Region: COG4717 869816005555 P-loop containing region of AAA domain; Region: AAA_29; cl17516 869816005556 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 869816005557 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 869816005558 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 869816005559 active site 869816005560 metal binding site [ion binding]; metal-binding site 869816005561 DNA binding site [nucleotide binding] 869816005562 hypothetical protein; Provisional; Region: PRK13676 869816005563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 869816005564 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869816005565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816005566 non-specific DNA binding site [nucleotide binding]; other site 869816005567 salt bridge; other site 869816005568 sequence-specific DNA binding site [nucleotide binding]; other site 869816005569 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869816005570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816005571 active site 869816005572 phosphorylation site [posttranslational modification] 869816005573 intermolecular recognition site; other site 869816005574 dimerization interface [polypeptide binding]; other site 869816005575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869816005576 DNA binding residues [nucleotide binding] 869816005577 dimerization interface [polypeptide binding]; other site 869816005578 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 869816005579 GAF domain; Region: GAF_3; pfam13492 869816005580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 869816005581 Histidine kinase; Region: HisKA_3; pfam07730 869816005582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816005583 ATP binding site [chemical binding]; other site 869816005584 Mg2+ binding site [ion binding]; other site 869816005585 G-X-G motif; other site 869816005586 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869816005587 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869816005588 active site 869816005589 fumarate hydratase; Reviewed; Region: fumC; PRK00485 869816005590 Class II fumarases; Region: Fumarase_classII; cd01362 869816005591 active site 869816005592 tetramer interface [polypeptide binding]; other site 869816005593 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 869816005594 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869816005595 active site 869816005596 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 869816005597 epoxyqueuosine reductase; Region: TIGR00276 869816005598 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 869816005599 HEAT repeats; Region: HEAT_2; pfam13646 869816005600 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869816005601 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869816005602 Walker A/P-loop; other site 869816005603 ATP binding site [chemical binding]; other site 869816005604 Q-loop/lid; other site 869816005605 ABC transporter signature motif; other site 869816005606 Walker B; other site 869816005607 D-loop; other site 869816005608 H-loop/switch region; other site 869816005609 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869816005610 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869816005611 substrate binding pocket [chemical binding]; other site 869816005612 membrane-bound complex binding site; other site 869816005613 hinge residues; other site 869816005614 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869816005615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816005616 dimer interface [polypeptide binding]; other site 869816005617 conserved gate region; other site 869816005618 putative PBP binding loops; other site 869816005619 ABC-ATPase subunit interface; other site 869816005620 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 869816005621 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 869816005622 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 869816005623 metal binding site 2 [ion binding]; metal-binding site 869816005624 putative DNA binding helix; other site 869816005625 metal binding site 1 [ion binding]; metal-binding site 869816005626 dimer interface [polypeptide binding]; other site 869816005627 structural Zn2+ binding site [ion binding]; other site 869816005628 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 869816005629 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 869816005630 putative ligand binding site [chemical binding]; other site 869816005631 NAD binding site [chemical binding]; other site 869816005632 catalytic site [active] 869816005633 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 869816005634 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 869816005635 catalytic triad [active] 869816005636 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 869816005637 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869816005638 inhibitor-cofactor binding pocket; inhibition site 869816005639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816005640 catalytic residue [active] 869816005641 Predicted membrane protein [Function unknown]; Region: COG4129 869816005642 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 869816005643 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869816005644 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869816005645 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 869816005646 Walker A/P-loop; other site 869816005647 ATP binding site [chemical binding]; other site 869816005648 Q-loop/lid; other site 869816005649 ABC transporter signature motif; other site 869816005650 Walker B; other site 869816005651 D-loop; other site 869816005652 H-loop/switch region; other site 869816005653 hypothetical protein; Provisional; Region: PRK13662 869816005654 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 869816005655 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869816005656 minor groove reading motif; other site 869816005657 helix-hairpin-helix signature motif; other site 869816005658 substrate binding pocket [chemical binding]; other site 869816005659 active site 869816005660 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 869816005661 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 869816005662 DNA binding and oxoG recognition site [nucleotide binding] 869816005663 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 869816005664 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 869816005665 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 869816005666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816005667 Walker A/P-loop; other site 869816005668 ATP binding site [chemical binding]; other site 869816005669 Q-loop/lid; other site 869816005670 ABC transporter signature motif; other site 869816005671 Walker B; other site 869816005672 H-loop/switch region; other site 869816005673 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 869816005674 recombination regulator RecX; Provisional; Region: recX; PRK14135 869816005675 glycosyltransferase; Provisional; Region: PRK13481 869816005676 Transglycosylase; Region: Transgly; pfam00912 869816005677 intracellular protease, PfpI family; Region: PfpI; TIGR01382 869816005678 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 869816005679 proposed catalytic triad [active] 869816005680 conserved cys residue [active] 869816005681 Radical SAM superfamily; Region: Radical_SAM; pfam04055 869816005682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869816005683 FeS/SAM binding site; other site 869816005684 YfkB-like domain; Region: YfkB; pfam08756 869816005685 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 869816005686 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 869816005687 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 869816005688 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 869816005689 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 869816005690 Low molecular weight phosphatase family; Region: LMWPc; cd00115 869816005691 active site 869816005692 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 869816005693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869816005694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816005695 active site 869816005696 phosphorylation site [posttranslational modification] 869816005697 intermolecular recognition site; other site 869816005698 dimerization interface [polypeptide binding]; other site 869816005699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869816005700 DNA binding residues [nucleotide binding] 869816005701 dimerization interface [polypeptide binding]; other site 869816005702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 869816005703 Histidine kinase; Region: HisKA_3; pfam07730 869816005704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816005705 ATP binding site [chemical binding]; other site 869816005706 Mg2+ binding site [ion binding]; other site 869816005707 G-X-G motif; other site 869816005708 Predicted membrane protein [Function unknown]; Region: COG4758 869816005709 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 869816005710 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 869816005711 active site 869816005712 Predicted membrane protein [Function unknown]; Region: COG4129 869816005713 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 869816005714 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 869816005715 catalytic triad [active] 869816005716 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 869816005717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869816005718 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 869816005719 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 869816005720 Ferritin-like domain; Region: Ferritin; pfam00210 869816005721 ferroxidase diiron center [ion binding]; other site 869816005722 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 869816005723 active site 869816005724 catalytic site [active] 869816005725 substrate binding site [chemical binding]; other site 869816005726 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 869816005727 active site 869816005728 DNA polymerase IV; Validated; Region: PRK02406 869816005729 DNA binding site [nucleotide binding] 869816005730 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 869816005731 TRAM domain; Region: TRAM; cl01282 869816005732 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 869816005733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816005734 S-adenosylmethionine binding site [chemical binding]; other site 869816005735 putative lipid kinase; Reviewed; Region: PRK13337 869816005736 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 869816005737 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 869816005738 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 869816005739 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 869816005740 GatB domain; Region: GatB_Yqey; pfam02637 869816005741 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 869816005742 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 869816005743 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 869816005744 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 869816005745 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 869816005746 Na binding site [ion binding]; other site 869816005747 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 869816005748 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 869816005749 putative dimer interface [polypeptide binding]; other site 869816005750 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 869816005751 putative dimer interface [polypeptide binding]; other site 869816005752 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 869816005753 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 869816005754 nucleotide binding pocket [chemical binding]; other site 869816005755 K-X-D-G motif; other site 869816005756 catalytic site [active] 869816005757 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 869816005758 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 869816005759 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 869816005760 Dimer interface [polypeptide binding]; other site 869816005761 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 869816005762 Part of AAA domain; Region: AAA_19; pfam13245 869816005763 Family description; Region: UvrD_C_2; pfam13538 869816005764 PcrB family; Region: PcrB; pfam01884 869816005765 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 869816005766 substrate binding site [chemical binding]; other site 869816005767 putative active site [active] 869816005768 dimer interface [polypeptide binding]; other site 869816005769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 869816005770 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 869816005771 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 869816005772 tetramer interface [polypeptide binding]; other site 869816005773 active site 869816005774 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 869816005775 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 869816005776 Staphostatin A; Region: Staphostatin_A; pfam09022 869816005777 NETI protein; Region: NETI; pfam14044 869816005778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 869816005779 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 869816005780 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 869816005781 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 869816005782 homodimer interface [polypeptide binding]; other site 869816005783 NAD binding pocket [chemical binding]; other site 869816005784 ATP binding pocket [chemical binding]; other site 869816005785 Mg binding site [ion binding]; other site 869816005786 active-site loop [active] 869816005787 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 869816005788 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 869816005789 active site 869816005790 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 869816005791 active site 869816005792 dimer interface [polypeptide binding]; other site 869816005793 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 869816005794 Prephenate dehydratase; Region: PDT; pfam00800 869816005795 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 869816005796 putative L-Phe binding site [chemical binding]; other site 869816005797 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869816005798 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 869816005799 transmembrane helices; other site 869816005800 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 869816005801 Isochorismatase family; Region: Isochorismatase; pfam00857 869816005802 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 869816005803 catalytic triad [active] 869816005804 conserved cis-peptide bond; other site 869816005805 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 869816005806 DHH family; Region: DHH; pfam01368 869816005807 DHHA2 domain; Region: DHHA2; pfam02833 869816005808 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 869816005809 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 869816005810 NAD(P) binding site [chemical binding]; other site 869816005811 catalytic residues [active] 869816005812 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 869816005813 YolD-like protein; Region: YolD; pfam08863 869816005814 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 869816005815 active site 869816005816 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 869816005817 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 869816005818 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 869816005819 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 869816005820 Bacterial PH domain; Region: DUF304; cl01348 869816005821 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 869816005822 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869816005823 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869816005824 Walker A/P-loop; other site 869816005825 ATP binding site [chemical binding]; other site 869816005826 Q-loop/lid; other site 869816005827 ABC transporter signature motif; other site 869816005828 Walker B; other site 869816005829 D-loop; other site 869816005830 H-loop/switch region; other site 869816005831 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 869816005832 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869816005833 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869816005834 Walker A/P-loop; other site 869816005835 ATP binding site [chemical binding]; other site 869816005836 Q-loop/lid; other site 869816005837 ABC transporter signature motif; other site 869816005838 Walker B; other site 869816005839 D-loop; other site 869816005840 H-loop/switch region; other site 869816005841 Predicted transcriptional regulators [Transcription]; Region: COG1725 869816005842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869816005843 DNA-binding site [nucleotide binding]; DNA binding site 869816005844 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 869816005845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869816005846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816005847 homodimer interface [polypeptide binding]; other site 869816005848 catalytic residue [active] 869816005849 MAP domain; Region: MAP; pfam03642 869816005850 MAP domain; Region: MAP; pfam03642 869816005851 MAP domain; Region: MAP; pfam03642 869816005852 MAP domain; Region: MAP; pfam03642 869816005853 MAP domain; Region: MAP; pfam03642 869816005854 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 869816005855 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 869816005856 Bacterial SH3 domain homologues; Region: SH3b; smart00287 869816005857 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 869816005858 CHAP domain; Region: CHAP; pfam05257 869816005859 Small integral membrane protein [Function unknown]; Region: COG5546 869816005860 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 869816005861 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 869816005862 TolA protein; Region: tolA_full; TIGR02794 869816005863 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 869816005864 Phage tail protein; Region: Sipho_tail; cl17486 869816005865 Phage tail protein; Region: Sipho_tail; cl17486 869816005866 Phage-related minor tail protein [Function unknown]; Region: COG5280 869816005867 Phage-related protein [Function unknown]; Region: COG5412 869816005868 Peptidase family M23; Region: Peptidase_M23; pfam01551 869816005869 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869816005870 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869816005871 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869816005872 catalytic residue [active] 869816005873 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 869816005874 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 869816005875 Translocation protein Sec62; Region: Sec62; cl02170 869816005876 Phage capsid family; Region: Phage_capsid; pfam05065 869816005877 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 869816005878 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 869816005879 oligomer interface [polypeptide binding]; other site 869816005880 active site residues [active] 869816005881 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 869816005882 Phage-related protein [Function unknown]; Region: COG4695; cl01923 869816005883 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 869816005884 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 869816005885 HNH endonuclease; Region: HNH; pfam01844 869816005886 active site 869816005887 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 869816005888 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 869816005889 Transcriptional activator RinB; Region: RinB; pfam06116 869816005890 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 869816005891 dUTPase; Region: dUTPase_2; pfam08761 869816005892 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 869816005893 active site 869816005894 homodimer interface [polypeptide binding]; other site 869816005895 metal binding site [ion binding]; metal-binding site 869816005896 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 869816005897 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 869816005898 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 869816005899 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 869816005900 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 869816005901 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 869816005902 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869816005903 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869816005904 dimer interface [polypeptide binding]; other site 869816005905 ssDNA binding site [nucleotide binding]; other site 869816005906 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869816005907 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 869816005908 RecT family; Region: RecT; pfam03837 869816005909 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 869816005910 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 869816005911 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 869816005912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 869816005913 Phage anti-repressor protein [Transcription]; Region: COG3561 869816005914 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 869816005915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816005916 salt bridge; other site 869816005917 non-specific DNA binding site [nucleotide binding]; other site 869816005918 sequence-specific DNA binding site [nucleotide binding]; other site 869816005919 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869816005920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816005921 non-specific DNA binding site [nucleotide binding]; other site 869816005922 salt bridge; other site 869816005923 sequence-specific DNA binding site [nucleotide binding]; other site 869816005924 Predicted transcriptional regulator [Transcription]; Region: COG2932 869816005925 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869816005926 Catalytic site [active] 869816005927 PemK-like protein; Region: PemK; pfam02452 869816005928 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 869816005929 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 869816005930 Int/Topo IB signature motif; other site 869816005931 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 869816005932 putative catalytic site [active] 869816005933 phosphate binding site [ion binding]; other site 869816005934 metal binding site A [ion binding]; metal-binding site 869816005935 metal binding site C [ion binding]; metal-binding site 869816005936 metal binding site B [ion binding]; metal-binding site 869816005937 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 869816005938 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 869816005939 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 869816005940 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 869816005941 metal binding site [ion binding]; metal-binding site 869816005942 dimer interface [polypeptide binding]; other site 869816005943 Cation transport protein; Region: TrkH; cl17365 869816005944 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869816005945 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 869816005946 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 869816005947 ring oligomerisation interface [polypeptide binding]; other site 869816005948 ATP/Mg binding site [chemical binding]; other site 869816005949 stacking interactions; other site 869816005950 hinge regions; other site 869816005951 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 869816005952 oligomerisation interface [polypeptide binding]; other site 869816005953 mobile loop; other site 869816005954 roof hairpin; other site 869816005955 CAAX protease self-immunity; Region: Abi; pfam02517 869816005956 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 869816005957 dimer interface [polypeptide binding]; other site 869816005958 FMN binding site [chemical binding]; other site 869816005959 Predicted amidohydrolase [General function prediction only]; Region: COG0388 869816005960 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 869816005961 putative active site [active] 869816005962 catalytic triad [active] 869816005963 putative dimer interface [polypeptide binding]; other site 869816005964 delta-hemolysin; Provisional; Region: PRK14752 869816005965 Accessory gene regulator B; Region: AgrB; smart00793 869816005966 Staphylococcal AgrD protein; Region: AgrD; smart00794 869816005967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816005968 Mg2+ binding site [ion binding]; other site 869816005969 G-X-G motif; other site 869816005970 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869816005971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816005972 active site 869816005973 phosphorylation site [posttranslational modification] 869816005974 intermolecular recognition site; other site 869816005975 dimerization interface [polypeptide binding]; other site 869816005976 LytTr DNA-binding domain; Region: LytTR; pfam04397 869816005977 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869816005978 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 869816005979 putative substrate binding site [chemical binding]; other site 869816005980 putative ATP binding site [chemical binding]; other site 869816005981 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 869816005982 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 869816005983 substrate binding [chemical binding]; other site 869816005984 active site 869816005985 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 869816005986 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869816005987 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869816005988 DNA binding site [nucleotide binding] 869816005989 domain linker motif; other site 869816005990 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 869816005991 dimerization interface [polypeptide binding]; other site 869816005992 ligand binding site [chemical binding]; other site 869816005993 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 869816005994 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 869816005995 CPxP motif; other site 869816005996 Predicted transporter component [General function prediction only]; Region: COG2391 869816005997 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 869816005998 Sulphur transport; Region: Sulf_transp; pfam04143 869816005999 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 869816006000 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 869816006001 CoA binding domain; Region: CoA_binding; pfam02629 869816006002 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869816006003 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869816006004 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869816006005 ABC transporter; Region: ABC_tran_2; pfam12848 869816006006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869816006007 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 869816006008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816006009 Walker A/P-loop; other site 869816006010 ATP binding site [chemical binding]; other site 869816006011 Q-loop/lid; other site 869816006012 ABC transporter signature motif; other site 869816006013 Walker B; other site 869816006014 D-loop; other site 869816006015 H-loop/switch region; other site 869816006016 UGMP family protein; Validated; Region: PRK09604 869816006017 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 869816006018 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 869816006019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816006020 Coenzyme A binding pocket [chemical binding]; other site 869816006021 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 869816006022 Glycoprotease family; Region: Peptidase_M22; pfam00814 869816006023 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 869816006024 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 869816006025 6-phosphogluconate dehydratase; Region: edd; TIGR01196 869816006026 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 869816006027 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869816006028 PYR/PP interface [polypeptide binding]; other site 869816006029 dimer interface [polypeptide binding]; other site 869816006030 TPP binding site [chemical binding]; other site 869816006031 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869816006032 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 869816006033 TPP-binding site [chemical binding]; other site 869816006034 dimer interface [polypeptide binding]; other site 869816006035 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 869816006036 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 869816006037 ketol-acid reductoisomerase; Provisional; Region: PRK05479 869816006038 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 869816006039 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 869816006040 2-isopropylmalate synthase; Validated; Region: PRK00915 869816006041 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 869816006042 active site 869816006043 catalytic residues [active] 869816006044 metal binding site [ion binding]; metal-binding site 869816006045 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 869816006046 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 869816006047 tartrate dehydrogenase; Region: TTC; TIGR02089 869816006048 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 869816006049 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 869816006050 substrate binding site [chemical binding]; other site 869816006051 ligand binding site [chemical binding]; other site 869816006052 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 869816006053 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 869816006054 substrate binding site [chemical binding]; other site 869816006055 threonine dehydratase; Validated; Region: PRK08639 869816006056 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 869816006057 tetramer interface [polypeptide binding]; other site 869816006058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816006059 catalytic residue [active] 869816006060 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 869816006061 putative Ile/Val binding site [chemical binding]; other site 869816006062 hypothetical protein; Provisional; Region: PRK04351 869816006063 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 869816006064 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 869816006065 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 869816006066 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 869816006067 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 869816006068 RNA binding site [nucleotide binding]; other site 869816006069 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 869816006070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869816006071 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869816006072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869816006073 DNA binding residues [nucleotide binding] 869816006074 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 869816006075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816006076 ATP binding site [chemical binding]; other site 869816006077 Mg2+ binding site [ion binding]; other site 869816006078 G-X-G motif; other site 869816006079 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 869816006080 anti sigma factor interaction site; other site 869816006081 regulatory phosphorylation site [posttranslational modification]; other site 869816006082 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 869816006083 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 869816006084 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 869816006085 PemK-like protein; Region: PemK; pfam02452 869816006086 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 869816006087 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 869816006088 active site 869816006089 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869816006090 dimer interface [polypeptide binding]; other site 869816006091 substrate binding site [chemical binding]; other site 869816006092 catalytic residues [active] 869816006093 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 869816006094 Uncharacterized conserved protein [Function unknown]; Region: COG3402 869816006095 Predicted membrane protein [Function unknown]; Region: COG3428 869816006096 Bacterial PH domain; Region: DUF304; pfam03703 869816006097 Bacterial PH domain; Region: DUF304; pfam03703 869816006098 Bacterial PH domain; Region: DUF304; cl01348 869816006099 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 869816006100 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 869816006101 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869816006102 Soluble P-type ATPase [General function prediction only]; Region: COG4087 869816006103 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 869816006104 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 869816006105 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 869816006106 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 869816006107 Ligand Binding Site [chemical binding]; other site 869816006108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869816006109 dimer interface [polypeptide binding]; other site 869816006110 phosphorylation site [posttranslational modification] 869816006111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816006112 Mg2+ binding site [ion binding]; other site 869816006113 G-X-G motif; other site 869816006114 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869816006115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816006116 active site 869816006117 phosphorylation site [posttranslational modification] 869816006118 intermolecular recognition site; other site 869816006119 dimerization interface [polypeptide binding]; other site 869816006120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869816006121 DNA binding site [nucleotide binding] 869816006122 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 869816006123 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869816006124 ATP binding site [chemical binding]; other site 869816006125 Mg++ binding site [ion binding]; other site 869816006126 motif III; other site 869816006127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869816006128 nucleotide binding region [chemical binding]; other site 869816006129 ATP-binding site [chemical binding]; other site 869816006130 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 869816006131 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869816006132 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869816006133 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869816006134 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 869816006135 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869816006136 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 869816006137 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 869816006138 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 869816006139 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 869816006140 putative homodimer interface [polypeptide binding]; other site 869816006141 putative homotetramer interface [polypeptide binding]; other site 869816006142 allosteric switch controlling residues; other site 869816006143 putative metal binding site [ion binding]; other site 869816006144 putative homodimer-homodimer interface [polypeptide binding]; other site 869816006145 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 869816006146 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 869816006147 putative active site [active] 869816006148 catalytic site [active] 869816006149 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 869816006150 putative active site [active] 869816006151 catalytic site [active] 869816006152 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 869816006153 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869816006154 Zn2+ binding site [ion binding]; other site 869816006155 Mg2+ binding site [ion binding]; other site 869816006156 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 869816006157 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869816006158 thiamine phosphate binding site [chemical binding]; other site 869816006159 active site 869816006160 pyrophosphate binding site [ion binding]; other site 869816006161 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869816006162 substrate binding site [chemical binding]; other site 869816006163 multimerization interface [polypeptide binding]; other site 869816006164 ATP binding site [chemical binding]; other site 869816006165 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869816006166 dimer interface [polypeptide binding]; other site 869816006167 substrate binding site [chemical binding]; other site 869816006168 ATP binding site [chemical binding]; other site 869816006169 thiaminase II; Region: salvage_TenA; TIGR04306 869816006170 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 869816006171 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869816006172 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869816006173 dimer interface [polypeptide binding]; other site 869816006174 ssDNA binding site [nucleotide binding]; other site 869816006175 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869816006176 YwpF-like protein; Region: YwpF; pfam14183 869816006177 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 869816006178 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869816006179 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869816006180 hinge; other site 869816006181 active site 869816006182 Predicted membrane protein [Function unknown]; Region: COG4836 869816006183 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 869816006184 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 869816006185 gamma subunit interface [polypeptide binding]; other site 869816006186 epsilon subunit interface [polypeptide binding]; other site 869816006187 LBP interface [polypeptide binding]; other site 869816006188 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 869816006189 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869816006190 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 869816006191 alpha subunit interaction interface [polypeptide binding]; other site 869816006192 Walker A motif; other site 869816006193 ATP binding site [chemical binding]; other site 869816006194 Walker B motif; other site 869816006195 inhibitor binding site; inhibition site 869816006196 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869816006197 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 869816006198 core domain interface [polypeptide binding]; other site 869816006199 delta subunit interface [polypeptide binding]; other site 869816006200 epsilon subunit interface [polypeptide binding]; other site 869816006201 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 869816006202 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869816006203 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 869816006204 beta subunit interaction interface [polypeptide binding]; other site 869816006205 Walker A motif; other site 869816006206 ATP binding site [chemical binding]; other site 869816006207 Walker B motif; other site 869816006208 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869816006209 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 869816006210 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 869816006211 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 869816006212 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 869816006213 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 869816006214 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 869816006215 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 869816006216 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 869816006217 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 869816006218 active site 869816006219 homodimer interface [polypeptide binding]; other site 869816006220 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869816006221 active site 869816006222 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 869816006223 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 869816006224 dimer interface [polypeptide binding]; other site 869816006225 active site 869816006226 glycine-pyridoxal phosphate binding site [chemical binding]; other site 869816006227 folate binding site [chemical binding]; other site 869816006228 hypothetical protein; Provisional; Region: PRK13690 869816006229 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 869816006230 Low molecular weight phosphatase family; Region: LMWPc; cd00115 869816006231 active site 869816006232 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 869816006233 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 869816006234 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 869816006235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816006236 S-adenosylmethionine binding site [chemical binding]; other site 869816006237 peptide chain release factor 1; Validated; Region: prfA; PRK00591 869816006238 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869816006239 RF-1 domain; Region: RF-1; pfam00472 869816006240 thymidine kinase; Provisional; Region: PRK04296 869816006241 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 869816006242 transcription termination factor Rho; Provisional; Region: rho; PRK09376 869816006243 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 869816006244 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 869816006245 RNA binding site [nucleotide binding]; other site 869816006246 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 869816006247 multimer interface [polypeptide binding]; other site 869816006248 Walker A motif; other site 869816006249 ATP binding site [chemical binding]; other site 869816006250 Walker B motif; other site 869816006251 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 869816006252 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 869816006253 NAD binding site [chemical binding]; other site 869816006254 catalytic residues [active] 869816006255 Predicted transcriptional regulators [Transcription]; Region: COG1733 869816006256 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 869816006257 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869816006258 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869816006259 hinge; other site 869816006260 active site 869816006261 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 869816006262 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869816006263 intersubunit interface [polypeptide binding]; other site 869816006264 active site 869816006265 zinc binding site [ion binding]; other site 869816006266 Na+ binding site [ion binding]; other site 869816006267 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 869816006268 CTP synthetase; Validated; Region: pyrG; PRK05380 869816006269 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 869816006270 Catalytic site [active] 869816006271 active site 869816006272 UTP binding site [chemical binding]; other site 869816006273 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 869816006274 active site 869816006275 putative oxyanion hole; other site 869816006276 catalytic triad [active] 869816006277 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 869816006278 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869816006279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816006280 Coenzyme A binding pocket [chemical binding]; other site 869816006281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869816006282 pantothenate kinase; Provisional; Region: PRK13317 869816006283 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 869816006284 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 869816006285 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 869816006286 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 869816006287 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 869816006288 metal binding site [ion binding]; metal-binding site 869816006289 S-ribosylhomocysteinase; Provisional; Region: PRK02260 869816006290 Predicted membrane protein [Function unknown]; Region: COG4270 869816006291 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 869816006292 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869816006293 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869816006294 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 869816006295 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 869816006296 intersubunit interface [polypeptide binding]; other site 869816006297 active site 869816006298 catalytic residue [active] 869816006299 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 869816006300 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 869816006301 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 869816006302 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 869816006303 dimerization interface [polypeptide binding]; other site 869816006304 DPS ferroxidase diiron center [ion binding]; other site 869816006305 ion pore; other site 869816006306 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 869816006307 EVE domain; Region: EVE; cl00728 869816006308 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 869816006309 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 869816006310 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 869816006311 NADH(P)-binding; Region: NAD_binding_10; pfam13460 869816006312 NAD(P) binding site [chemical binding]; other site 869816006313 putative active site [active] 869816006314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869816006315 dimerization interface [polypeptide binding]; other site 869816006316 putative DNA binding site [nucleotide binding]; other site 869816006317 putative Zn2+ binding site [ion binding]; other site 869816006318 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 869816006319 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 869816006320 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869816006321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816006322 active site 869816006323 motif I; other site 869816006324 motif II; other site 869816006325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816006326 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869816006327 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869816006328 Walker A/P-loop; other site 869816006329 ATP binding site [chemical binding]; other site 869816006330 Q-loop/lid; other site 869816006331 ABC transporter signature motif; other site 869816006332 Walker B; other site 869816006333 D-loop; other site 869816006334 H-loop/switch region; other site 869816006335 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 869816006336 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 869816006337 glutaminase active site [active] 869816006338 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869816006339 dimer interface [polypeptide binding]; other site 869816006340 active site 869816006341 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 869816006342 dimer interface [polypeptide binding]; other site 869816006343 active site 869816006344 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 869816006345 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 869816006346 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 869816006347 active site 869816006348 P-loop; other site 869816006349 phosphorylation site [posttranslational modification] 869816006350 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869816006351 HTH domain; Region: HTH_11; pfam08279 869816006352 Mga helix-turn-helix domain; Region: Mga; pfam05043 869816006353 PRD domain; Region: PRD; pfam00874 869816006354 PRD domain; Region: PRD; pfam00874 869816006355 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869816006356 active site 869816006357 P-loop; other site 869816006358 phosphorylation site [posttranslational modification] 869816006359 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 869816006360 active site 869816006361 phosphorylation site [posttranslational modification] 869816006362 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869816006363 active site 869816006364 phosphorylation site [posttranslational modification] 869816006365 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 869816006366 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 869816006367 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 869816006368 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816006369 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 869816006370 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816006371 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816006372 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816006373 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816006374 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816006375 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816006376 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816006377 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869816006378 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 869816006379 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 869816006380 active site 869816006381 substrate binding site [chemical binding]; other site 869816006382 metal binding site [ion binding]; metal-binding site 869816006383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 869816006384 YbbR-like protein; Region: YbbR; pfam07949 869816006385 TIGR00159 family protein; Region: TIGR00159 869816006386 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 869816006387 Arginase family; Region: Arginase; cd09989 869816006388 active site 869816006389 Mn binding site [ion binding]; other site 869816006390 oligomer interface [polypeptide binding]; other site 869816006391 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 869816006392 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 869816006393 Walker A motif; other site 869816006394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816006395 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 869816006396 putative substrate translocation pore; other site 869816006397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816006398 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816006399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816006400 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 869816006401 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 869816006402 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 869816006403 substrate binding site; other site 869816006404 dimerization interface; other site 869816006405 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 869816006406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 869816006407 Nucleoside recognition; Region: Gate; pfam07670 869816006408 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869816006409 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816006410 ABC-ATPase subunit interface; other site 869816006411 dimer interface [polypeptide binding]; other site 869816006412 putative PBP binding regions; other site 869816006413 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 869816006414 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869816006415 ABC-ATPase subunit interface; other site 869816006416 dimer interface [polypeptide binding]; other site 869816006417 putative PBP binding regions; other site 869816006418 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 869816006419 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 869816006420 siderophore binding site; other site 869816006421 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 869816006422 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 869816006423 dimer interface [polypeptide binding]; other site 869816006424 active site 869816006425 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869816006426 substrate binding site [chemical binding]; other site 869816006427 catalytic residue [active] 869816006428 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 869816006429 IucA / IucC family; Region: IucA_IucC; pfam04183 869816006430 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 869816006431 H+ Antiporter protein; Region: 2A0121; TIGR00900 869816006432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816006433 putative substrate translocation pore; other site 869816006434 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 869816006435 IucA / IucC family; Region: IucA_IucC; pfam04183 869816006436 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 869816006437 Asp23 family; Region: Asp23; pfam03780 869816006438 Small integral membrane protein [Function unknown]; Region: COG5547 869816006439 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 869816006440 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 869816006441 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 869816006442 putative NAD(P) binding site [chemical binding]; other site 869816006443 dimer interface [polypeptide binding]; other site 869816006444 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 869816006445 Prostaglandin dehydrogenases; Region: PGDH; cd05288 869816006446 NAD(P) binding site [chemical binding]; other site 869816006447 substrate binding site [chemical binding]; other site 869816006448 dimer interface [polypeptide binding]; other site 869816006449 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 869816006450 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 869816006451 beta-galactosidase; Region: BGL; TIGR03356 869816006452 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 869816006453 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869816006454 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 869816006455 active site 869816006456 P-loop; other site 869816006457 phosphorylation site [posttranslational modification] 869816006458 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869816006459 methionine cluster; other site 869816006460 active site 869816006461 phosphorylation site [posttranslational modification] 869816006462 metal binding site [ion binding]; metal-binding site 869816006463 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 869816006464 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869816006465 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 869816006466 putative substrate binding site [chemical binding]; other site 869816006467 putative ATP binding site [chemical binding]; other site 869816006468 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 869816006469 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 869816006470 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869816006471 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869816006472 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869816006473 NAD-dependent deacetylase; Provisional; Region: PRK00481 869816006474 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 869816006475 NAD+ binding site [chemical binding]; other site 869816006476 substrate binding site [chemical binding]; other site 869816006477 putative Zn binding site [ion binding]; other site 869816006478 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 869816006479 active site 869816006480 catalytic residues [active] 869816006481 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 869816006482 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869816006483 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869816006484 active site 869816006485 catalytic tetrad [active] 869816006486 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 869816006487 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 869816006488 DNA binding residues [nucleotide binding] 869816006489 putative dimer interface [polypeptide binding]; other site 869816006490 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 869816006491 substrate binding site [chemical binding]; other site 869816006492 catalytic residues [active] 869816006493 Predicted transcriptional regulator [Transcription]; Region: COG2378 869816006494 HTH domain; Region: HTH_11; pfam08279 869816006495 WYL domain; Region: WYL; pfam13280 869816006496 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 869816006497 conserved cys residue [active] 869816006498 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 869816006499 acetolactate synthase; Reviewed; Region: PRK08617 869816006500 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869816006501 PYR/PP interface [polypeptide binding]; other site 869816006502 dimer interface [polypeptide binding]; other site 869816006503 TPP binding site [chemical binding]; other site 869816006504 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869816006505 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 869816006506 TPP-binding site [chemical binding]; other site 869816006507 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 869816006508 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 869816006509 putative active site [active] 869816006510 putative NTP binding site [chemical binding]; other site 869816006511 putative nucleic acid binding site [nucleotide binding]; other site 869816006512 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 869816006513 AAA domain; Region: AAA_13; pfam13166 869816006514 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 869816006515 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 869816006516 23S rRNA interface [nucleotide binding]; other site 869816006517 L3 interface [polypeptide binding]; other site 869816006518 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 869816006519 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 869816006520 dimerization interface 3.5A [polypeptide binding]; other site 869816006521 active site 869816006522 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869816006523 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 869816006524 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869816006525 Walker A/P-loop; other site 869816006526 ATP binding site [chemical binding]; other site 869816006527 Q-loop/lid; other site 869816006528 ABC transporter signature motif; other site 869816006529 Walker B; other site 869816006530 D-loop; other site 869816006531 H-loop/switch region; other site 869816006532 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 869816006533 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869816006534 Walker A/P-loop; other site 869816006535 ATP binding site [chemical binding]; other site 869816006536 Q-loop/lid; other site 869816006537 ABC transporter signature motif; other site 869816006538 Walker B; other site 869816006539 D-loop; other site 869816006540 H-loop/switch region; other site 869816006541 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 869816006542 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 869816006543 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 869816006544 alphaNTD homodimer interface [polypeptide binding]; other site 869816006545 alphaNTD - beta interaction site [polypeptide binding]; other site 869816006546 alphaNTD - beta' interaction site [polypeptide binding]; other site 869816006547 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 869816006548 30S ribosomal protein S11; Validated; Region: PRK05309 869816006549 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 869816006550 30S ribosomal protein S13; Region: bact_S13; TIGR03631 869816006551 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 869816006552 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 869816006553 rRNA binding site [nucleotide binding]; other site 869816006554 predicted 30S ribosome binding site; other site 869816006555 adenylate kinase; Reviewed; Region: adk; PRK00279 869816006556 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 869816006557 AMP-binding site [chemical binding]; other site 869816006558 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 869816006559 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 869816006560 SecY translocase; Region: SecY; pfam00344 869816006561 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 869816006562 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 869816006563 23S rRNA binding site [nucleotide binding]; other site 869816006564 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 869816006565 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 869816006566 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 869816006567 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 869816006568 5S rRNA interface [nucleotide binding]; other site 869816006569 L27 interface [polypeptide binding]; other site 869816006570 23S rRNA interface [nucleotide binding]; other site 869816006571 L5 interface [polypeptide binding]; other site 869816006572 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 869816006573 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869816006574 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869816006575 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 869816006576 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 869816006577 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 869816006578 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 869816006579 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 869816006580 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 869816006581 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 869816006582 RNA binding site [nucleotide binding]; other site 869816006583 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 869816006584 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 869816006585 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 869816006586 23S rRNA interface [nucleotide binding]; other site 869816006587 putative translocon interaction site; other site 869816006588 signal recognition particle (SRP54) interaction site; other site 869816006589 L23 interface [polypeptide binding]; other site 869816006590 trigger factor interaction site; other site 869816006591 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 869816006592 23S rRNA interface [nucleotide binding]; other site 869816006593 5S rRNA interface [nucleotide binding]; other site 869816006594 putative antibiotic binding site [chemical binding]; other site 869816006595 L25 interface [polypeptide binding]; other site 869816006596 L27 interface [polypeptide binding]; other site 869816006597 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 869816006598 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 869816006599 G-X-X-G motif; other site 869816006600 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 869816006601 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 869816006602 putative translocon binding site; other site 869816006603 protein-rRNA interface [nucleotide binding]; other site 869816006604 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 869816006605 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 869816006606 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 869816006607 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 869816006608 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 869816006609 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 869816006610 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 869816006611 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 869816006612 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 869816006613 DNA topoisomerase III; Provisional; Region: PRK07726 869816006614 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 869816006615 active site 869816006616 putative interdomain interaction site [polypeptide binding]; other site 869816006617 putative metal-binding site [ion binding]; other site 869816006618 putative nucleotide binding site [chemical binding]; other site 869816006619 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 869816006620 domain I; other site 869816006621 DNA binding groove [nucleotide binding] 869816006622 phosphate binding site [ion binding]; other site 869816006623 domain II; other site 869816006624 domain III; other site 869816006625 nucleotide binding site [chemical binding]; other site 869816006626 catalytic site [active] 869816006627 domain IV; other site 869816006628 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 869816006629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816006630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869816006631 Coenzyme A binding pocket [chemical binding]; other site 869816006632 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 869816006633 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 869816006634 Predicted permeases [General function prediction only]; Region: COG0679 869816006635 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 869816006636 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 869816006637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 869816006638 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 869816006639 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 869816006640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816006641 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816006642 putative substrate translocation pore; other site 869816006643 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816006644 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869816006645 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 869816006646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869816006647 FeS/SAM binding site; other site 869816006648 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 869816006649 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 869816006650 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 869816006651 GTP binding site; other site 869816006652 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 869816006653 MoaE interaction surface [polypeptide binding]; other site 869816006654 MoeB interaction surface [polypeptide binding]; other site 869816006655 thiocarboxylated glycine; other site 869816006656 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 869816006657 MoaE homodimer interface [polypeptide binding]; other site 869816006658 MoaD interaction [polypeptide binding]; other site 869816006659 active site residues [active] 869816006660 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 869816006661 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 869816006662 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 869816006663 dimer interface [polypeptide binding]; other site 869816006664 putative functional site; other site 869816006665 putative MPT binding site; other site 869816006666 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 869816006667 trimer interface [polypeptide binding]; other site 869816006668 dimer interface [polypeptide binding]; other site 869816006669 putative active site [active] 869816006670 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 869816006671 MPT binding site; other site 869816006672 trimer interface [polypeptide binding]; other site 869816006673 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 869816006674 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 869816006675 ATP binding site [chemical binding]; other site 869816006676 substrate interface [chemical binding]; other site 869816006677 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869816006678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816006679 Walker A/P-loop; other site 869816006680 ATP binding site [chemical binding]; other site 869816006681 Q-loop/lid; other site 869816006682 ABC transporter signature motif; other site 869816006683 Walker B; other site 869816006684 D-loop; other site 869816006685 H-loop/switch region; other site 869816006686 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 869816006687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816006688 dimer interface [polypeptide binding]; other site 869816006689 conserved gate region; other site 869816006690 putative PBP binding loops; other site 869816006691 ABC-ATPase subunit interface; other site 869816006692 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 869816006693 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869816006694 substrate binding pocket [chemical binding]; other site 869816006695 membrane-bound complex binding site; other site 869816006696 hinge residues; other site 869816006697 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 869816006698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816006699 Coenzyme A binding pocket [chemical binding]; other site 869816006700 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 869816006701 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 869816006702 active site 869816006703 dimerization interface [polypeptide binding]; other site 869816006704 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 869816006705 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 869816006706 intersubunit interface [polypeptide binding]; other site 869816006707 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 869816006708 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 869816006709 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 869816006710 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 869816006711 alpha-gamma subunit interface [polypeptide binding]; other site 869816006712 beta-gamma subunit interface [polypeptide binding]; other site 869816006713 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 869816006714 gamma-beta subunit interface [polypeptide binding]; other site 869816006715 alpha-beta subunit interface [polypeptide binding]; other site 869816006716 urease subunit alpha; Reviewed; Region: ureC; PRK13207 869816006717 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 869816006718 subunit interactions [polypeptide binding]; other site 869816006719 active site 869816006720 flap region; other site 869816006721 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 869816006722 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 869816006723 dimer interface [polypeptide binding]; other site 869816006724 catalytic residues [active] 869816006725 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 869816006726 UreF; Region: UreF; pfam01730 869816006727 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869816006728 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 869816006729 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816006730 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816006731 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816006732 Helix-turn-helix domain; Region: HTH_18; pfam12833 869816006733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869816006734 Surface antigen [General function prediction only]; Region: COG3942 869816006735 CHAP domain; Region: CHAP; pfam05257 869816006736 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 869816006737 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869816006738 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 869816006739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 869816006740 Surface antigen [General function prediction only]; Region: COG3942 869816006741 CHAP domain; Region: CHAP; pfam05257 869816006742 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 869816006743 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 869816006744 putative ligand binding site [chemical binding]; other site 869816006745 putative NAD binding site [chemical binding]; other site 869816006746 catalytic site [active] 869816006747 hypothetical protein; Provisional; Region: PRK06753 869816006748 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 869816006749 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 869816006750 Lysozyme subfamily 2; Region: LYZ2; smart00047 869816006751 Uncharacterized conserved protein [Function unknown]; Region: COG2427 869816006752 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 869816006753 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 869816006754 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 869816006755 4Fe-4S binding domain; Region: Fer4; pfam00037 869816006756 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 869816006757 [4Fe-4S] binding site [ion binding]; other site 869816006758 molybdopterin cofactor binding site; other site 869816006759 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 869816006760 molybdopterin cofactor binding site; other site 869816006761 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 869816006762 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 869816006763 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 869816006764 active site 869816006765 Predicted transcriptional regulator [Transcription]; Region: COG2378 869816006766 HTH domain; Region: HTH_11; pfam08279 869816006767 CAAX protease self-immunity; Region: Abi; pfam02517 869816006768 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869816006769 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869816006770 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869816006771 putative active site [active] 869816006772 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 869816006773 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 869816006774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816006775 active site 869816006776 motif I; other site 869816006777 motif II; other site 869816006778 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 869816006779 Sodium Bile acid symporter family; Region: SBF; pfam01758 869816006780 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 869816006781 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869816006782 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869816006783 active site turn [active] 869816006784 phosphorylation site [posttranslational modification] 869816006785 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869816006786 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869816006787 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869816006788 putative active site [active] 869816006789 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 869816006790 putative hydrophobic ligand binding site [chemical binding]; other site 869816006791 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 869816006792 oxidoreductase; Provisional; Region: PRK07985 869816006793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869816006794 NAD(P) binding site [chemical binding]; other site 869816006795 active site 869816006796 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 869816006797 amidohydrolase; Region: amidohydrolases; TIGR01891 869816006798 metal binding site [ion binding]; metal-binding site 869816006799 dimer interface [polypeptide binding]; other site 869816006800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869816006801 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816006802 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869816006803 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816006804 imidazolonepropionase; Validated; Region: PRK09356 869816006805 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 869816006806 active site 869816006807 urocanate hydratase; Provisional; Region: PRK05414 869816006808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869816006809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869816006810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869816006811 dimerization interface [polypeptide binding]; other site 869816006812 formimidoylglutamase; Provisional; Region: PRK13775 869816006813 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 869816006814 putative active site [active] 869816006815 putative metal binding site [ion binding]; other site 869816006816 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 869816006817 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 869816006818 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869816006819 active site 869816006820 dimer interface [polypeptide binding]; other site 869816006821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 869816006822 MOSC domain; Region: MOSC; pfam03473 869816006823 3-alpha domain; Region: 3-alpha; pfam03475 869816006824 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 869816006825 active site 869816006826 catalytic residues [active] 869816006827 Uncharacterized conserved protein [Function unknown]; Region: COG1742 869816006828 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 869816006829 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 869816006830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816006831 Walker A/P-loop; other site 869816006832 ATP binding site [chemical binding]; other site 869816006833 Q-loop/lid; other site 869816006834 ABC transporter signature motif; other site 869816006835 Walker B; other site 869816006836 D-loop; other site 869816006837 H-loop/switch region; other site 869816006838 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 869816006839 Predicted membrane protein [Function unknown]; Region: COG3152 869816006840 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 869816006841 active site 869816006842 DNA binding site [nucleotide binding] 869816006843 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 869816006844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869816006845 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816006846 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869816006847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869816006848 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 869816006849 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 869816006850 homotetramer interface [polypeptide binding]; other site 869816006851 FMN binding site [chemical binding]; other site 869816006852 homodimer contacts [polypeptide binding]; other site 869816006853 putative active site [active] 869816006854 putative substrate binding site [chemical binding]; other site 869816006855 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869816006856 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 869816006857 oligomer interface [polypeptide binding]; other site 869816006858 metal binding site [ion binding]; metal-binding site 869816006859 metal binding site [ion binding]; metal-binding site 869816006860 putative Cl binding site [ion binding]; other site 869816006861 aspartate ring; other site 869816006862 basic sphincter; other site 869816006863 hydrophobic gate; other site 869816006864 periplasmic entrance; other site 869816006865 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869816006866 active site 869816006867 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 869816006868 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 869816006869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816006870 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 869816006871 putative substrate translocation pore; other site 869816006872 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 869816006873 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 869816006874 lipoyl-biotinyl attachment site [posttranslational modification]; other site 869816006875 HlyD family secretion protein; Region: HlyD_3; pfam13437 869816006876 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 869816006877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816006878 putative substrate translocation pore; other site 869816006879 Predicted membrane protein [Function unknown]; Region: COG4640 869816006880 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 869816006881 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869816006882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869816006883 putative Zn2+ binding site [ion binding]; other site 869816006884 putative DNA binding site [nucleotide binding]; other site 869816006885 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 869816006886 Uncharacterized conserved protein [Function unknown]; Region: COG1434 869816006887 putative active site [active] 869816006888 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869816006889 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869816006890 Walker A/P-loop; other site 869816006891 ATP binding site [chemical binding]; other site 869816006892 Q-loop/lid; other site 869816006893 ABC transporter signature motif; other site 869816006894 Walker B; other site 869816006895 D-loop; other site 869816006896 H-loop/switch region; other site 869816006897 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869816006898 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869816006899 FtsX-like permease family; Region: FtsX; pfam02687 869816006900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869816006901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816006902 active site 869816006903 phosphorylation site [posttranslational modification] 869816006904 intermolecular recognition site; other site 869816006905 dimerization interface [polypeptide binding]; other site 869816006906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869816006907 DNA binding site [nucleotide binding] 869816006908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869816006909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869816006910 dimerization interface [polypeptide binding]; other site 869816006911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869816006912 dimer interface [polypeptide binding]; other site 869816006913 phosphorylation site [posttranslational modification] 869816006914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816006915 ATP binding site [chemical binding]; other site 869816006916 Mg2+ binding site [ion binding]; other site 869816006917 G-X-G motif; other site 869816006918 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869816006919 LytTr DNA-binding domain; Region: LytTR; smart00850 869816006920 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 869816006921 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 869816006922 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 869816006923 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 869816006924 L-lactate permease; Region: Lactate_perm; cl00701 869816006925 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 869816006926 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869816006927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816006928 Coenzyme A binding pocket [chemical binding]; other site 869816006929 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 869816006930 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 869816006931 NAD(P) binding site [chemical binding]; other site 869816006932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816006933 Coenzyme A binding pocket [chemical binding]; other site 869816006934 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 869816006935 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869816006936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816006937 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 869816006938 Predicted membrane protein [Function unknown]; Region: COG1511 869816006939 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 869816006940 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 869816006941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869816006942 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 869816006943 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869816006944 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 869816006945 Cl binding site [ion binding]; other site 869816006946 oligomer interface [polypeptide binding]; other site 869816006947 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 869816006948 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869816006949 active site turn [active] 869816006950 phosphorylation site [posttranslational modification] 869816006951 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869816006952 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 869816006953 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869816006954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869816006955 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 869816006956 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 869816006957 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 869816006958 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 869816006959 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 869816006960 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869816006961 MarR family; Region: MarR_2; pfam12802 869816006962 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 869816006963 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 869816006964 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 869816006965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816006966 putative substrate translocation pore; other site 869816006967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869816006968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816006969 active site 869816006970 phosphorylation site [posttranslational modification] 869816006971 intermolecular recognition site; other site 869816006972 dimerization interface [polypeptide binding]; other site 869816006973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869816006974 DNA binding residues [nucleotide binding] 869816006975 dimerization interface [polypeptide binding]; other site 869816006976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 869816006977 Histidine kinase; Region: HisKA_3; pfam07730 869816006978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816006979 ATP binding site [chemical binding]; other site 869816006980 Mg2+ binding site [ion binding]; other site 869816006981 G-X-G motif; other site 869816006982 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 869816006983 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 869816006984 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 869816006985 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 869816006986 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 869816006987 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 869816006988 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 869816006989 [4Fe-4S] binding site [ion binding]; other site 869816006990 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869816006991 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869816006992 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869816006993 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 869816006994 molybdopterin cofactor binding site; other site 869816006995 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 869816006996 active site 869816006997 SAM binding site [chemical binding]; other site 869816006998 homodimer interface [polypeptide binding]; other site 869816006999 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 869816007000 [2Fe-2S] cluster binding site [ion binding]; other site 869816007001 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 869816007002 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869816007003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869816007004 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 869816007005 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 869816007006 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 869816007007 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 869816007008 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 869816007009 putative active site [active] 869816007010 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 869816007011 active site 869816007012 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 869816007013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816007014 Coenzyme A binding pocket [chemical binding]; other site 869816007015 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 869816007016 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 869816007017 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 869816007018 putative hydrophobic ligand binding site [chemical binding]; other site 869816007019 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869816007020 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 869816007021 intersubunit interface [polypeptide binding]; other site 869816007022 YodA lipocalin-like domain; Region: YodA; pfam09223 869816007023 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 869816007024 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 869816007025 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 869816007026 Thioredoxin; Region: Thioredoxin_4; cl17273 869816007027 FemAB family; Region: FemAB; pfam02388 869816007028 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869816007029 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869816007030 Walker A/P-loop; other site 869816007031 ATP binding site [chemical binding]; other site 869816007032 Q-loop/lid; other site 869816007033 ABC transporter signature motif; other site 869816007034 Walker B; other site 869816007035 D-loop; other site 869816007036 H-loop/switch region; other site 869816007037 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869816007038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816007039 dimer interface [polypeptide binding]; other site 869816007040 conserved gate region; other site 869816007041 putative PBP binding loops; other site 869816007042 ABC-ATPase subunit interface; other site 869816007043 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869816007044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869816007045 substrate binding pocket [chemical binding]; other site 869816007046 membrane-bound complex binding site; other site 869816007047 hinge residues; other site 869816007048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816007049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816007050 putative substrate translocation pore; other site 869816007051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816007052 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869816007053 catalytic core [active] 869816007054 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869816007055 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 869816007056 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 869816007057 B domain; Region: B; pfam02216 869816007058 B domain; Region: B; pfam02216 869816007059 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 869816007060 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 869816007061 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 869816007062 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 869816007063 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 869816007064 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 869816007065 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 869816007066 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869816007067 catalytic residue [active] 869816007068 biotin synthase; Validated; Region: PRK06256 869816007069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869816007070 FeS/SAM binding site; other site 869816007071 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 869816007072 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869816007073 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 869816007074 inhibitor-cofactor binding pocket; inhibition site 869816007075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816007076 catalytic residue [active] 869816007077 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 869816007078 AAA domain; Region: AAA_26; pfam13500 869816007079 Predicted membrane protein [Function unknown]; Region: COG2246 869816007080 GtrA-like protein; Region: GtrA; pfam04138 869816007081 glycerate kinase; Region: TIGR00045 869816007082 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 869816007083 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 869816007084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816007085 putative substrate translocation pore; other site 869816007086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 869816007087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 869816007088 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 869816007089 putative phosphoesterase; Region: acc_ester; TIGR03729 869816007090 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 869816007091 Spore germination protein; Region: Spore_permease; cl17796 869816007092 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 869816007093 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 869816007094 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 869816007095 Beta-lactamase; Region: Beta-lactamase; pfam00144 869816007096 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 869816007097 extended (e) SDRs; Region: SDR_e; cd08946 869816007098 NAD(P) binding site [chemical binding]; other site 869816007099 active site 869816007100 substrate binding site [chemical binding]; other site 869816007101 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 869816007102 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 869816007103 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 869816007104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816007105 putative substrate translocation pore; other site 869816007106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816007107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816007108 dimer interface [polypeptide binding]; other site 869816007109 conserved gate region; other site 869816007110 ABC-ATPase subunit interface; other site 869816007111 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 869816007112 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 869816007113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816007114 dimer interface [polypeptide binding]; other site 869816007115 conserved gate region; other site 869816007116 putative PBP binding loops; other site 869816007117 ABC-ATPase subunit interface; other site 869816007118 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 869816007119 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 869816007120 Walker A/P-loop; other site 869816007121 ATP binding site [chemical binding]; other site 869816007122 Q-loop/lid; other site 869816007123 ABC transporter signature motif; other site 869816007124 Walker B; other site 869816007125 D-loop; other site 869816007126 H-loop/switch region; other site 869816007127 FOG: CBS domain [General function prediction only]; Region: COG0517 869816007128 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 869816007129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 869816007130 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 869816007131 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 869816007132 amino acid transporter; Region: 2A0306; TIGR00909 869816007133 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 869816007134 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 869816007135 substrate binding pocket [chemical binding]; other site 869816007136 catalytic triad [active] 869816007137 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 869816007138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816007139 putative substrate translocation pore; other site 869816007140 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 869816007141 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 869816007142 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869816007143 Walker A/P-loop; other site 869816007144 ATP binding site [chemical binding]; other site 869816007145 Q-loop/lid; other site 869816007146 ABC transporter signature motif; other site 869816007147 Walker B; other site 869816007148 D-loop; other site 869816007149 H-loop/switch region; other site 869816007150 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869816007151 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 869816007152 oligomer interface [polypeptide binding]; other site 869816007153 active site 869816007154 metal binding site [ion binding]; metal-binding site 869816007155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 869816007156 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 869816007157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 869816007158 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 869816007159 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 869816007160 active site 869816007161 FMN binding site [chemical binding]; other site 869816007162 substrate binding site [chemical binding]; other site 869816007163 3Fe-4S cluster binding site [ion binding]; other site 869816007164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816007165 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816007166 putative substrate translocation pore; other site 869816007167 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869816007168 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869816007169 Walker A/P-loop; other site 869816007170 ATP binding site [chemical binding]; other site 869816007171 Q-loop/lid; other site 869816007172 ABC transporter signature motif; other site 869816007173 Walker B; other site 869816007174 D-loop; other site 869816007175 H-loop/switch region; other site 869816007176 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869816007177 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 869816007178 Walker A/P-loop; other site 869816007179 ATP binding site [chemical binding]; other site 869816007180 Q-loop/lid; other site 869816007181 ABC transporter signature motif; other site 869816007182 Walker B; other site 869816007183 D-loop; other site 869816007184 H-loop/switch region; other site 869816007185 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869816007186 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 869816007187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816007188 dimer interface [polypeptide binding]; other site 869816007189 conserved gate region; other site 869816007190 putative PBP binding loops; other site 869816007191 ABC-ATPase subunit interface; other site 869816007192 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869816007193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869816007194 dimer interface [polypeptide binding]; other site 869816007195 conserved gate region; other site 869816007196 putative PBP binding loops; other site 869816007197 ABC-ATPase subunit interface; other site 869816007198 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 869816007199 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 869816007200 substrate binding site [chemical binding]; other site 869816007201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 869816007202 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 869816007203 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 869816007204 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 869816007205 short chain dehydrogenase; Validated; Region: PRK08589 869816007206 classical (c) SDRs; Region: SDR_c; cd05233 869816007207 NAD(P) binding site [chemical binding]; other site 869816007208 active site 869816007209 AbgT putative transporter family; Region: ABG_transport; pfam03806 869816007210 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 869816007211 Uncharacterized conserved protein [Function unknown]; Region: COG2128 869816007212 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 869816007213 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 869816007214 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 869816007215 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 869816007216 classical (c) SDRs; Region: SDR_c; cd05233 869816007217 NAD(P) binding site [chemical binding]; other site 869816007218 active site 869816007219 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 869816007220 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816007221 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816007222 Protein of unknown function, DUF576; Region: DUF576; pfam04507 869816007223 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 869816007224 PLD-like domain; Region: PLDc_2; pfam13091 869816007225 putative homodimer interface [polypeptide binding]; other site 869816007226 putative active site [active] 869816007227 catalytic site [active] 869816007228 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 869816007229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869816007230 ATP binding site [chemical binding]; other site 869816007231 putative Mg++ binding site [ion binding]; other site 869816007232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869816007233 nucleotide binding region [chemical binding]; other site 869816007234 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 869816007235 ATP-binding site [chemical binding]; other site 869816007236 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 869816007237 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 869816007238 active site 869816007239 8-oxo-dGMP binding site [chemical binding]; other site 869816007240 nudix motif; other site 869816007241 metal binding site [ion binding]; metal-binding site 869816007242 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 869816007243 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 869816007244 active site 869816007245 substrate binding site [chemical binding]; other site 869816007246 metal binding site [ion binding]; metal-binding site 869816007247 legume lectins; Region: lectin_L-type; cl14058 869816007248 homotetramer interaction site [polypeptide binding]; other site 869816007249 carbohydrate binding site [chemical binding]; other site 869816007250 metal binding site [ion binding]; metal-binding site 869816007251 Rib/alpha-like repeat; Region: Rib; cl07159 869816007252 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816007253 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816007254 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869816007255 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816007256 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869816007257 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 869816007258 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869816007259 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 869816007260 active site 869816007261 tetramer interface; other site 869816007262 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816007263 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 869816007264 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869816007265 GntP family permease; Region: GntP_permease; pfam02447 869816007266 fructuronate transporter; Provisional; Region: PRK10034; cl15264 869816007267 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 869816007268 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 869816007269 N- and C-terminal domain interface [polypeptide binding]; other site 869816007270 active site 869816007271 catalytic site [active] 869816007272 metal binding site [ion binding]; metal-binding site 869816007273 carbohydrate binding site [chemical binding]; other site 869816007274 ATP binding site [chemical binding]; other site 869816007275 Transcriptional regulators [Transcription]; Region: GntR; COG1802 869816007276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869816007277 DNA-binding site [nucleotide binding]; DNA binding site 869816007278 FCD domain; Region: FCD; pfam07729 869816007279 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 869816007280 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 869816007281 DNA binding residues [nucleotide binding] 869816007282 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869816007283 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 869816007284 synthetase active site [active] 869816007285 NTP binding site [chemical binding]; other site 869816007286 metal binding site [ion binding]; metal-binding site 869816007287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 869816007288 Predicted membrane protein [Function unknown]; Region: COG1289 869816007289 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869816007290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816007291 D-galactonate transporter; Region: 2A0114; TIGR00893 869816007292 putative substrate translocation pore; other site 869816007293 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 869816007294 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869816007295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869816007296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869816007297 putative substrate translocation pore; other site 869816007298 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869816007299 MarR family; Region: MarR; pfam01047 869816007300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816007301 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 869816007302 Walker A/P-loop; other site 869816007303 ATP binding site [chemical binding]; other site 869816007304 Q-loop/lid; other site 869816007305 ABC transporter signature motif; other site 869816007306 Walker B; other site 869816007307 D-loop; other site 869816007308 H-loop/switch region; other site 869816007309 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 869816007310 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 869816007311 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 869816007312 Uncharacterized membrane protein [Function unknown]; Region: COG3949 869816007313 Predicted esterase [General function prediction only]; Region: COG0400 869816007314 putative hydrolase; Provisional; Region: PRK11460 869816007315 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 869816007316 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869816007317 Zn binding site [ion binding]; other site 869816007318 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 869816007319 Zn binding site [ion binding]; other site 869816007320 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869816007321 MarR family; Region: MarR; pfam01047 869816007322 MarR family; Region: MarR_2; cl17246 869816007323 Predicted acetyltransferase [General function prediction only]; Region: COG2388 869816007324 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 869816007325 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 869816007326 putative metal binding site [ion binding]; other site 869816007327 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869816007328 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 869816007329 dimer interface [polypeptide binding]; other site 869816007330 FMN binding site [chemical binding]; other site 869816007331 D-lactate dehydrogenase; Provisional; Region: PRK12480 869816007332 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 869816007333 homodimer interface [polypeptide binding]; other site 869816007334 ligand binding site [chemical binding]; other site 869816007335 NAD binding site [chemical binding]; other site 869816007336 catalytic site [active] 869816007337 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869816007338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869816007339 active site 869816007340 motif I; other site 869816007341 motif II; other site 869816007342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869816007343 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869816007344 Walker A/P-loop; other site 869816007345 ATP binding site [chemical binding]; other site 869816007346 Q-loop/lid; other site 869816007347 ABC transporter signature motif; other site 869816007348 Walker B; other site 869816007349 D-loop; other site 869816007350 H-loop/switch region; other site 869816007351 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 869816007352 active site 869816007353 catalytic site [active] 869816007354 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 869816007355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816007356 Coenzyme A binding pocket [chemical binding]; other site 869816007357 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 869816007358 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 869816007359 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 869816007360 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 869816007361 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 869816007362 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869816007363 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 869816007364 EamA-like transporter family; Region: EamA; pfam00892 869816007365 EamA-like transporter family; Region: EamA; pfam00892 869816007366 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 869816007367 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 869816007368 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869816007369 catalytic residues [active] 869816007370 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869816007371 active site 869816007372 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869816007373 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 869816007374 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869816007375 active site turn [active] 869816007376 phosphorylation site [posttranslational modification] 869816007377 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869816007378 HPr interaction site; other site 869816007379 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869816007380 active site 869816007381 phosphorylation site [posttranslational modification] 869816007382 pyruvate oxidase; Provisional; Region: PRK08611 869816007383 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 869816007384 PYR/PP interface [polypeptide binding]; other site 869816007385 tetramer interface [polypeptide binding]; other site 869816007386 dimer interface [polypeptide binding]; other site 869816007387 TPP binding site [chemical binding]; other site 869816007388 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869816007389 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 869816007390 TPP-binding site [chemical binding]; other site 869816007391 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 869816007392 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 869816007393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869816007394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869816007395 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 869816007396 putative dimerization interface [polypeptide binding]; other site 869816007397 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 869816007398 Surface antigen [General function prediction only]; Region: COG3942 869816007399 CHAP domain; Region: CHAP; pfam05257 869816007400 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 869816007401 homodimer interface [polypeptide binding]; other site 869816007402 catalytic residues [active] 869816007403 NAD binding site [chemical binding]; other site 869816007404 substrate binding pocket [chemical binding]; other site 869816007405 flexible flap; other site 869816007406 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 869816007407 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 869816007408 dimer interface [polypeptide binding]; other site 869816007409 active site 869816007410 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 869816007411 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 869816007412 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 869816007413 DNA binding site [nucleotide binding] 869816007414 active site 869816007415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816007416 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869816007417 Walker A motif; other site 869816007418 ATP binding site [chemical binding]; other site 869816007419 Walker B motif; other site 869816007420 arginine finger; other site 869816007421 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 869816007422 UvrB/uvrC motif; Region: UVR; pfam02151 869816007423 MoxR-like ATPases [General function prediction only]; Region: COG0714 869816007424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869816007425 Walker A motif; other site 869816007426 ATP binding site [chemical binding]; other site 869816007427 Walker B motif; other site 869816007428 arginine finger; other site 869816007429 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869816007430 Virus attachment protein p12 family; Region: P12; pfam12669 869816007431 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 869816007432 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 869816007433 G1 box; other site 869816007434 GTP/Mg2+ binding site [chemical binding]; other site 869816007435 Switch I region; other site 869816007436 G2 box; other site 869816007437 G3 box; other site 869816007438 Switch II region; other site 869816007439 G4 box; other site 869816007440 G5 box; other site 869816007441 Nucleoside recognition; Region: Gate; pfam07670 869816007442 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 869816007443 Nucleoside recognition; Region: Gate; pfam07670 869816007444 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 869816007445 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 869816007446 Protein export membrane protein; Region: SecD_SecF; cl14618 869816007447 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 869816007448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869816007449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869816007450 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 869816007451 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 869816007452 Glutamate binding site [chemical binding]; other site 869816007453 homodimer interface [polypeptide binding]; other site 869816007454 NAD binding site [chemical binding]; other site 869816007455 catalytic residues [active] 869816007456 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 869816007457 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 869816007458 active site 869816007459 substrate binding site [chemical binding]; other site 869816007460 trimer interface [polypeptide binding]; other site 869816007461 CoA binding site [chemical binding]; other site 869816007462 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 869816007463 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869816007464 metal-binding site [ion binding] 869816007465 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 869816007466 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869816007467 metal-binding site [ion binding] 869816007468 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869816007469 Soluble P-type ATPase [General function prediction only]; Region: COG4087 869816007470 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 869816007471 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869816007472 metal-binding site [ion binding] 869816007473 D-lactate dehydrogenase; Validated; Region: PRK08605 869816007474 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 869816007475 homodimer interface [polypeptide binding]; other site 869816007476 ligand binding site [chemical binding]; other site 869816007477 NAD binding site [chemical binding]; other site 869816007478 catalytic site [active] 869816007479 transaminase; Reviewed; Region: PRK08068 869816007480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869816007481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816007482 homodimer interface [polypeptide binding]; other site 869816007483 catalytic residue [active] 869816007484 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 869816007485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869816007486 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 869816007487 active site lid residues [active] 869816007488 substrate binding pocket [chemical binding]; other site 869816007489 catalytic residues [active] 869816007490 substrate-Mg2+ binding site; other site 869816007491 aspartate-rich region 1; other site 869816007492 aspartate-rich region 2; other site 869816007493 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869816007494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869816007495 active site 869816007496 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 869816007497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869816007498 Surface antigen [General function prediction only]; Region: COG3942 869816007499 CHAP domain; Region: CHAP; pfam05257 869816007500 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 869816007501 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 869816007502 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 869816007503 catalytic triad [active] 869816007504 catalytic triad [active] 869816007505 oxyanion hole [active] 869816007506 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869816007507 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869816007508 catalytic residue [active] 869816007509 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 869816007510 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 869816007511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869816007512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869816007513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 869816007514 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 869816007515 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869816007516 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 869816007517 NmrA-like family; Region: NmrA; pfam05368 869816007518 NADP binding site [chemical binding]; other site 869816007519 active site 869816007520 regulatory binding site [polypeptide binding]; other site 869816007521 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 869816007522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869816007523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869816007524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869816007525 tropinone reductase; Provisional; Region: PRK09242 869816007526 NAD(P) binding site [chemical binding]; other site 869816007527 active site 869816007528 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 869816007529 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 869816007530 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 869816007531 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 869816007532 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 869816007533 Nucleoside recognition; Region: Gate; pfam07670 869816007534 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 869816007535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 869816007536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 869816007537 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 869816007538 Phosphotransferase enzyme family; Region: APH; pfam01636 869816007539 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 869816007540 active site 869816007541 ATP binding site [chemical binding]; other site 869816007542 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 869816007543 active site 869816007544 ATP binding site [chemical binding]; other site 869816007545 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 869816007546 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 869816007547 quinone interaction residues [chemical binding]; other site 869816007548 active site 869816007549 catalytic residues [active] 869816007550 FMN binding site [chemical binding]; other site 869816007551 substrate binding site [chemical binding]; other site 869816007552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 869816007553 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 869816007554 dimer interface [polypeptide binding]; other site 869816007555 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869816007556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869816007557 Predicted acyl esterases [General function prediction only]; Region: COG2936 869816007558 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 869816007559 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 869816007560 tetramerization interface [polypeptide binding]; other site 869816007561 active site 869816007562 pantoate--beta-alanine ligase; Region: panC; TIGR00018 869816007563 Pantoate-beta-alanine ligase; Region: PanC; cd00560 869816007564 active site 869816007565 ATP-binding site [chemical binding]; other site 869816007566 pantoate-binding site; other site 869816007567 HXXH motif; other site 869816007568 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 869816007569 oligomerization interface [polypeptide binding]; other site 869816007570 active site 869816007571 metal binding site [ion binding]; metal-binding site 869816007572 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 869816007573 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 869816007574 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 869816007575 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 869816007576 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 869816007577 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 869816007578 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869816007579 NAD binding site [chemical binding]; other site 869816007580 dimer interface [polypeptide binding]; other site 869816007581 substrate binding site [chemical binding]; other site 869816007582 amino acid transporter; Region: 2A0306; TIGR00909 869816007583 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 869816007584 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869816007585 inhibitor-cofactor binding pocket; inhibition site 869816007586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816007587 catalytic residue [active] 869816007588 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 869816007589 catalytic residue [active] 869816007590 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 869816007591 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 869816007592 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 869816007593 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 869816007594 acyl-activating enzyme (AAE) consensus motif; other site 869816007595 AMP binding site [chemical binding]; other site 869816007596 active site 869816007597 CoA binding site [chemical binding]; other site 869816007598 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 869816007599 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 869816007600 choline dehydrogenase; Validated; Region: PRK02106 869816007601 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 869816007602 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 869816007603 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 869816007604 tetramerization interface [polypeptide binding]; other site 869816007605 NAD(P) binding site [chemical binding]; other site 869816007606 catalytic residues [active] 869816007607 Predicted transcriptional regulators [Transcription]; Region: COG1510 869816007608 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 869816007609 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 869816007610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869816007611 FeS/SAM binding site; other site 869816007612 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 869816007613 Class III ribonucleotide reductase; Region: RNR_III; cd01675 869816007614 effector binding site; other site 869816007615 active site 869816007616 Zn binding site [ion binding]; other site 869816007617 glycine loop; other site 869816007618 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 869816007619 Citrate transporter; Region: CitMHS; pfam03600 869816007620 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 869816007621 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 869816007622 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 869816007623 Flavodoxin; Region: Flavodoxin_1; pfam00258 869816007624 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 869816007625 FAD binding pocket [chemical binding]; other site 869816007626 FAD binding motif [chemical binding]; other site 869816007627 catalytic residues [active] 869816007628 NAD binding pocket [chemical binding]; other site 869816007629 phosphate binding motif [ion binding]; other site 869816007630 beta-alpha-beta structure motif; other site 869816007631 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 869816007632 catalytic residues [active] 869816007633 dimer interface [polypeptide binding]; other site 869816007634 FtsX-like permease family; Region: FtsX; pfam02687 869816007635 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869816007636 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869816007637 Walker A/P-loop; other site 869816007638 ATP binding site [chemical binding]; other site 869816007639 Q-loop/lid; other site 869816007640 ABC transporter signature motif; other site 869816007641 Walker B; other site 869816007642 D-loop; other site 869816007643 H-loop/switch region; other site 869816007644 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869816007645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869816007646 ATP binding site [chemical binding]; other site 869816007647 Mg2+ binding site [ion binding]; other site 869816007648 G-X-G motif; other site 869816007649 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869816007650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869816007651 active site 869816007652 phosphorylation site [posttranslational modification] 869816007653 intermolecular recognition site; other site 869816007654 dimerization interface [polypeptide binding]; other site 869816007655 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869816007656 DNA binding site [nucleotide binding] 869816007657 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 869816007658 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 869816007659 dimer interface [polypeptide binding]; other site 869816007660 active site 869816007661 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 869816007662 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869816007663 MarR family; Region: MarR_2; pfam12802 869816007664 Predicted esterase [General function prediction only]; Region: COG0627 869816007665 S-formylglutathione hydrolase; Region: PLN02442 869816007666 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869816007667 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 869816007668 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 869816007669 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 869816007670 ligand binding site [chemical binding]; other site 869816007671 flexible hinge region; other site 869816007672 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 869816007673 carbamate kinase; Reviewed; Region: PRK12686 869816007674 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869816007675 putative substrate binding site [chemical binding]; other site 869816007676 nucleotide binding site [chemical binding]; other site 869816007677 nucleotide binding site [chemical binding]; other site 869816007678 homodimer interface [polypeptide binding]; other site 869816007679 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 869816007680 ornithine carbamoyltransferase; Validated; Region: PRK02102 869816007681 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869816007682 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869816007683 arginine deiminase; Provisional; Region: PRK01388 869816007684 Arginine repressor [Transcription]; Region: ArgR; COG1438 869816007685 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869816007686 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869816007687 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 869816007688 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 869816007689 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 869816007690 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 869816007691 active site 869816007692 Zn binding site [ion binding]; other site 869816007693 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869816007694 HTH domain; Region: HTH_11; pfam08279 869816007695 PRD domain; Region: PRD; pfam00874 869816007696 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869816007697 active site 869816007698 P-loop; other site 869816007699 phosphorylation site [posttranslational modification] 869816007700 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869816007701 active site 869816007702 phosphorylation site [posttranslational modification] 869816007703 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 869816007704 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869816007705 active site 869816007706 P-loop; other site 869816007707 phosphorylation site [posttranslational modification] 869816007708 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869816007709 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869816007710 active site 869816007711 phosphorylation site [posttranslational modification] 869816007712 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 869816007713 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 869816007714 Predicted membrane protein [Function unknown]; Region: COG1511 869816007715 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 869816007716 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 869816007717 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 869816007718 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 869816007719 CHAP domain; Region: CHAP; pfam05257 869816007720 Isochorismatase family; Region: Isochorismatase; pfam00857 869816007721 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 869816007722 catalytic triad [active] 869816007723 conserved cis-peptide bond; other site 869816007724 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 869816007725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869816007726 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 869816007727 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 869816007728 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 869816007729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869816007730 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 869816007731 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 869816007732 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 869816007733 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 869816007734 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869816007735 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 869816007736 SecY translocase; Region: SecY; pfam00344 869816007737 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 869816007738 legume lectins; Region: lectin_L-type; cd01951 869816007739 homotetramer interaction site [polypeptide binding]; other site 869816007740 carbohydrate binding site [chemical binding]; other site 869816007741 metal binding site [ion binding]; metal-binding site 869816007742 Putative Ig domain; Region: He_PIG; pfam05345 869816007743 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 869816007744 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 869816007745 methionine sulfoxide reductase A; Provisional; Region: PRK05528 869816007746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 869816007747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869816007748 Coenzyme A binding pocket [chemical binding]; other site 869816007749 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 869816007750 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 869816007751 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869816007752 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 869816007753 Chain length determinant protein; Region: Wzz; cl15801 869816007754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869816007755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869816007756 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 869816007757 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 869816007758 DXD motif; other site 869816007759 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 869816007760 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 869816007761 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 869816007762 Acyltransferase family; Region: Acyl_transf_3; pfam01757 869816007763 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869816007764 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 869816007765 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 869816007766 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 869816007767 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 869816007768 metal binding site [ion binding]; metal-binding site 869816007769 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 869816007770 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 869816007771 substrate binding site [chemical binding]; other site 869816007772 glutamase interaction surface [polypeptide binding]; other site 869816007773 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 869816007774 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 869816007775 catalytic residues [active] 869816007776 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 869816007777 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 869816007778 putative active site [active] 869816007779 oxyanion strand; other site 869816007780 catalytic triad [active] 869816007781 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 869816007782 putative active site pocket [active] 869816007783 4-fold oligomerization interface [polypeptide binding]; other site 869816007784 metal binding residues [ion binding]; metal-binding site 869816007785 3-fold/trimer interface [polypeptide binding]; other site 869816007786 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 869816007787 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869816007788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869816007789 homodimer interface [polypeptide binding]; other site 869816007790 catalytic residue [active] 869816007791 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 869816007792 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 869816007793 NAD binding site [chemical binding]; other site 869816007794 dimerization interface [polypeptide binding]; other site 869816007795 product binding site; other site 869816007796 substrate binding site [chemical binding]; other site 869816007797 zinc binding site [ion binding]; other site 869816007798 catalytic residues [active] 869816007799 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 869816007800 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 869816007801 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 869816007802 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 869816007803 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 869816007804 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 869816007805 putative active site [active] 869816007806 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869816007807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869816007808 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869816007809 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869816007810 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869816007811 Walker A/P-loop; other site 869816007812 ATP binding site [chemical binding]; other site 869816007813 Q-loop/lid; other site 869816007814 ABC transporter signature motif; other site 869816007815 Walker B; other site 869816007816 D-loop; other site 869816007817 H-loop/switch region; other site 869816007818 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 869816007819 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869816007820 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869816007821 Walker A/P-loop; other site 869816007822 ATP binding site [chemical binding]; other site 869816007823 Q-loop/lid; other site 869816007824 ABC transporter signature motif; other site 869816007825 Walker B; other site 869816007826 D-loop; other site 869816007827 H-loop/switch region; other site 869816007828 hypothetical protein; Provisional; Region: PRK13661 869816007829 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 869816007830 Uncharacterized conserved protein [Function unknown]; Region: COG1912 869816007831 Uncharacterized conserved protein [Function unknown]; Region: COG2353 869816007832 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 869816007833 Strictosidine synthase; Region: Str_synth; pfam03088 869816007834 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 869816007835 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 869816007836 active site residue [active] 869816007837 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 869816007838 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 869816007839 putative substrate binding pocket [chemical binding]; other site 869816007840 AC domain interface; other site 869816007841 catalytic triad [active] 869816007842 AB domain interface; other site 869816007843 interchain disulfide; other site 869816007844 DinB superfamily; Region: DinB_2; pfam12867 869816007845 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869816007846 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 869816007847 transmembrane helices; other site 869816007848 Predicted permeases [General function prediction only]; Region: RarD; COG2962 869816007849 EamA-like transporter family; Region: EamA; pfam00892 869816007850 hypothetical protein; Provisional; Region: PRK07758 869816007851 SnoaL-like domain; Region: SnoaL_2; pfam12680 869816007852 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 869816007853 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 869816007854 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 869816007855 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869816007856 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869816007857 Walker A/P-loop; other site 869816007858 ATP binding site [chemical binding]; other site 869816007859 Q-loop/lid; other site 869816007860 ABC transporter signature motif; other site 869816007861 Walker B; other site 869816007862 D-loop; other site 869816007863 H-loop/switch region; other site 869816007864 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869816007865 FtsX-like permease family; Region: FtsX; pfam02687 869816007866 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 869816007867 DNA-binding site [nucleotide binding]; DNA binding site 869816007868 RNA-binding motif; other site 869816007869 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869816007870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816007871 non-specific DNA binding site [nucleotide binding]; other site 869816007872 salt bridge; other site 869816007873 sequence-specific DNA binding site [nucleotide binding]; other site 869816007874 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 869816007875 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 869816007876 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 869816007877 ParB-like nuclease domain; Region: ParBc; pfam02195 869816007878 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 869816007879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869816007880 S-adenosylmethionine binding site [chemical binding]; other site 869816007881 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 869816007882 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 869816007883 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 869816007884 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 869816007885 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 869816007886 trmE is a tRNA modification GTPase; Region: trmE; cd04164 869816007887 G1 box; other site 869816007888 GTP/Mg2+ binding site [chemical binding]; other site 869816007889 Switch I region; other site 869816007890 G2 box; other site 869816007891 Switch II region; other site 869816007892 G3 box; other site 869816007893 G4 box; other site 869816007894 G5 box; other site 869816007895 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 869816007896 ribonuclease P; Reviewed; Region: rnpA; PRK00499 869816007897 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 869816007898 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 869816007899 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 869816007900 Cadmium resistance transporter; Region: Cad; pfam03596 869816007901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869816007902 putative DNA binding site [nucleotide binding]; other site 869816007903 putative Zn2+ binding site [ion binding]; other site 869816007904 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 869816007905 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 869816007906 Helix-turn-helix domain; Region: HTH_28; pfam13518 869816007907 Winged helix-turn helix; Region: HTH_29; pfam13551 869816007908 Homeodomain-like domain; Region: HTH_32; pfam13565 869816007909 Integrase core domain; Region: rve; pfam00665 869816007910 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 869816007911 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 869816007912 catalytic residues [active] 869816007913 catalytic nucleophile [active] 869816007914 Presynaptic Site I dimer interface [polypeptide binding]; other site 869816007915 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 869816007916 Synaptic Flat tetramer interface [polypeptide binding]; other site 869816007917 Synaptic Site I dimer interface [polypeptide binding]; other site 869816007918 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869816007919 DNA-binding interface [nucleotide binding]; DNA binding site 869816007920 Predicted transcriptional regulator [Transcription]; Region: COG3682 869816007921 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 869816007922 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 869816007923 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 869816007924 beta-lactamase TEM; Provisional; Region: PRK15442 869816007925 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 869816007926 multiple promoter invertase; Provisional; Region: mpi; PRK13413 869816007927 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 869816007928 catalytic residues [active] 869816007929 catalytic nucleophile [active] 869816007930 Presynaptic Site I dimer interface [polypeptide binding]; other site 869816007931 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 869816007932 Synaptic Flat tetramer interface [polypeptide binding]; other site 869816007933 Synaptic Site I dimer interface [polypeptide binding]; other site 869816007934 DNA binding site [nucleotide binding] 869816007935 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869816007936 DNA-binding interface [nucleotide binding]; DNA binding site 869816007937 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 869816007938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869816007939 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869816007940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 869816007941 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869816007942 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869816007943 Walker A/P-loop; other site 869816007944 ATP binding site [chemical binding]; other site 869816007945 Q-loop/lid; other site 869816007946 ABC transporter signature motif; other site 869816007947 Walker B; other site 869816007948 D-loop; other site 869816007949 H-loop/switch region; other site 869816007950 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 869816007951 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 869816007952 Initiator Replication protein; Region: Rep_3; pfam01051 869816007953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869816007954 non-specific DNA binding site [nucleotide binding]; other site 869816007955 salt bridge; other site 869816007956 sequence-specific DNA binding site [nucleotide binding]; other site