-- dump date 20140620_074103 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1118959000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1118959000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1118959000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959000004 Walker A motif; other site 1118959000005 ATP binding site [chemical binding]; other site 1118959000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1118959000007 Walker B motif; other site 1118959000008 arginine finger; other site 1118959000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1118959000010 DnaA box-binding interface [nucleotide binding]; other site 1118959000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1118959000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1118959000013 putative DNA binding surface [nucleotide binding]; other site 1118959000014 dimer interface [polypeptide binding]; other site 1118959000015 beta-clamp/clamp loader binding surface; other site 1118959000016 beta-clamp/translesion DNA polymerase binding surface; other site 1118959000017 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1118959000018 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1118959000019 recF protein; Region: recf; TIGR00611 1118959000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1118959000021 Walker A/P-loop; other site 1118959000022 ATP binding site [chemical binding]; other site 1118959000023 Q-loop/lid; other site 1118959000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959000025 ABC transporter signature motif; other site 1118959000026 Walker B; other site 1118959000027 D-loop; other site 1118959000028 H-loop/switch region; other site 1118959000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1118959000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959000031 Mg2+ binding site [ion binding]; other site 1118959000032 G-X-G motif; other site 1118959000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1118959000034 anchoring element; other site 1118959000035 dimer interface [polypeptide binding]; other site 1118959000036 ATP binding site [chemical binding]; other site 1118959000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1118959000038 active site 1118959000039 putative metal-binding site [ion binding]; other site 1118959000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1118959000041 DNA gyrase subunit A; Validated; Region: PRK05560 1118959000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1118959000043 CAP-like domain; other site 1118959000044 active site 1118959000045 primary dimer interface [polypeptide binding]; other site 1118959000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1118959000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1118959000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1118959000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1118959000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1118959000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1118959000052 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1118959000053 putative substrate binding site [chemical binding]; other site 1118959000054 putative ATP binding site [chemical binding]; other site 1118959000055 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1118959000056 active sites [active] 1118959000057 tetramer interface [polypeptide binding]; other site 1118959000058 seryl-tRNA synthetase; Provisional; Region: PRK05431 1118959000059 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1118959000060 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1118959000061 dimer interface [polypeptide binding]; other site 1118959000062 active site 1118959000063 motif 1; other site 1118959000064 motif 2; other site 1118959000065 motif 3; other site 1118959000066 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1118959000067 Predicted membrane protein [Function unknown]; Region: COG4392 1118959000068 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1118959000069 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1118959000070 Predicted membrane protein [Function unknown]; Region: COG4241 1118959000071 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1118959000072 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1118959000073 DHH family; Region: DHH; pfam01368 1118959000074 DHHA1 domain; Region: DHHA1; pfam02272 1118959000075 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1118959000076 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1118959000077 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1118959000078 replicative DNA helicase; Region: DnaB; TIGR00665 1118959000079 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1118959000080 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1118959000081 Walker A motif; other site 1118959000082 ATP binding site [chemical binding]; other site 1118959000083 Walker B motif; other site 1118959000084 DNA binding loops [nucleotide binding] 1118959000085 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1118959000086 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1118959000087 GDP-binding site [chemical binding]; other site 1118959000088 ACT binding site; other site 1118959000089 IMP binding site; other site 1118959000090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1118959000091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959000092 active site 1118959000093 phosphorylation site [posttranslational modification] 1118959000094 intermolecular recognition site; other site 1118959000095 dimerization interface [polypeptide binding]; other site 1118959000096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1118959000097 DNA binding site [nucleotide binding] 1118959000098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1118959000099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1118959000100 dimerization interface [polypeptide binding]; other site 1118959000101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1118959000102 putative active site [active] 1118959000103 heme pocket [chemical binding]; other site 1118959000104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1118959000105 dimer interface [polypeptide binding]; other site 1118959000106 phosphorylation site [posttranslational modification] 1118959000107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959000108 ATP binding site [chemical binding]; other site 1118959000109 Mg2+ binding site [ion binding]; other site 1118959000110 G-X-G motif; other site 1118959000111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1118959000112 YycH protein; Region: YycH; pfam07435 1118959000113 YycH protein; Region: YycI; cl02015 1118959000114 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1118959000115 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1118959000116 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1118959000117 putative active site [active] 1118959000118 putative metal binding site [ion binding]; other site 1118959000119 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1118959000120 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1118959000121 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1118959000122 type V Staphylococcal cassette mec; SCCmec type V 1118959000123 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1118959000124 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 1118959000125 GIY-YIG motif/motif A; other site 1118959000126 putative active site [active] 1118959000127 putative metal binding site [ion binding]; other site 1118959000128 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1118959000129 active site 1118959000130 DNA binding site [nucleotide binding] 1118959000131 catalytic site [active] 1118959000132 Phage associated DNA primase [General function prediction only]; Region: COG3378 1118959000133 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1118959000134 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1118959000135 catalytic residues [active] 1118959000136 catalytic nucleophile [active] 1118959000137 Recombinase; Region: Recombinase; pfam07508 1118959000138 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1118959000139 FlxA-like protein; Region: FlxA; pfam14282 1118959000140 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1118959000141 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1118959000142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1118959000143 Integrase core domain; Region: rve; pfam00665 1118959000144 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1118959000145 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1118959000146 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1118959000147 putative active site [active] 1118959000148 catalytic site [active] 1118959000149 putative metal binding site [ion binding]; other site 1118959000150 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1118959000151 putative active site [active] 1118959000152 putative catalytic site [active] 1118959000153 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1118959000154 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1118959000155 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1118959000156 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1118959000157 transposase IS431, truncated 1118959000158 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1118959000159 dimer interface [polypeptide binding]; other site 1118959000160 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1118959000161 Predicted transcriptional regulator [Transcription]; Region: COG2378 1118959000162 HTH domain; Region: HTH_11; pfam08279 1118959000163 WYL domain; Region: WYL; pfam13280 1118959000164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1118959000165 Homeodomain-like domain; Region: HTH_23; cl17451 1118959000166 putative transposase OrfB; Reviewed; Region: PHA02517 1118959000167 HTH-like domain; Region: HTH_21; pfam13276 1118959000168 Integrase core domain; Region: rve; pfam00665 1118959000169 Integrase core domain; Region: rve_3; cl15866 1118959000170 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1118959000171 active site 1118959000172 DNA binding site [nucleotide binding] 1118959000173 catalytic site [active] 1118959000174 Phage associated DNA primase [General function prediction only]; Region: COG3378 1118959000175 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1118959000176 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1118959000177 catalytic residues [active] 1118959000178 catalytic nucleophile [active] 1118959000179 Recombinase; Region: Recombinase; pfam07508 1118959000180 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1118959000181 FlxA-like protein; Region: FlxA; pfam14282 1118959000182 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 1118959000183 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1118959000184 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1118959000185 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1118959000186 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1118959000187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1118959000188 ATP binding site [chemical binding]; other site 1118959000189 putative Mg++ binding site [ion binding]; other site 1118959000190 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1118959000191 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1118959000192 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1118959000193 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1118959000194 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1118959000195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959000196 S-adenosylmethionine binding site [chemical binding]; other site 1118959000197 AAA ATPase domain; Region: AAA_15; pfam13175 1118959000198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959000199 Walker A/P-loop; other site 1118959000200 ATP binding site [chemical binding]; other site 1118959000201 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1118959000202 putative active site [active] 1118959000203 putative metal-binding site [ion binding]; other site 1118959000204 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1118959000205 Part of AAA domain; Region: AAA_19; pfam13245 1118959000206 Family description; Region: UvrD_C_2; pfam13538 1118959000207 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1118959000208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959000209 catalytic residue [active] 1118959000210 SIR2-like domain; Region: SIR2_2; pfam13289 1118959000211 potential frameshift: common BLAST hit: gi|126463956|ref|YP_001045069.1| ATPase-like protein 1118959000212 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1118959000213 Domain of unknown function DUF87; Region: DUF87; pfam01935 1118959000214 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1118959000215 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1118959000216 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1118959000217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1118959000218 putative DNA binding site [nucleotide binding]; other site 1118959000219 putative Zn2+ binding site [ion binding]; other site 1118959000220 AsnC family; Region: AsnC_trans_reg; pfam01037 1118959000221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959000222 Coenzyme A binding pocket [chemical binding]; other site 1118959000223 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1118959000224 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1118959000225 FMN binding site [chemical binding]; other site 1118959000226 active site 1118959000227 catalytic residues [active] 1118959000228 substrate binding site [chemical binding]; other site 1118959000229 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1118959000230 H+ Antiporter protein; Region: 2A0121; TIGR00900 1118959000231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959000232 putative substrate translocation pore; other site 1118959000233 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1118959000234 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1118959000235 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1118959000236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1118959000237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1118959000238 Winged helix-turn helix; Region: HTH_29; pfam13551 1118959000239 Integrase core domain; Region: rve; pfam00665 1118959000240 transposase/IS protein; Provisional; Region: PRK09183 1118959000241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959000242 Walker A motif; other site 1118959000243 ATP binding site [chemical binding]; other site 1118959000244 Walker B motif; other site 1118959000245 arginine finger; other site 1118959000246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1118959000247 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1118959000248 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1118959000249 Part of AAA domain; Region: AAA_19; pfam13245 1118959000250 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1118959000251 AAA domain; Region: AAA_12; pfam13087 1118959000252 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1118959000253 active site 1118959000254 catalytic site [active] 1118959000255 putative metal binding site [ion binding]; other site 1118959000256 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959000257 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959000258 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1118959000259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1118959000260 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1118959000261 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1118959000262 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1118959000263 metal binding site [ion binding]; metal-binding site 1118959000264 dimer interface [polypeptide binding]; other site 1118959000265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959000266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1118959000267 putative substrate translocation pore; other site 1118959000268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959000269 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1118959000270 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1118959000271 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1118959000272 PhoU domain; Region: PhoU; pfam01895 1118959000273 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1118959000274 EamA-like transporter family; Region: EamA; pfam00892 1118959000275 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1118959000276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1118959000277 DNA-binding site [nucleotide binding]; DNA binding site 1118959000278 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1118959000279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959000280 homodimer interface [polypeptide binding]; other site 1118959000281 catalytic residue [active] 1118959000282 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1118959000283 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1118959000284 L-lactate permease; Region: Lactate_perm; cl00701 1118959000285 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1118959000286 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1118959000287 B domain; Region: B; pfam02216 1118959000288 B domain; Region: B; pfam02216 1118959000289 B domain; Region: B; pfam02216 1118959000290 B domain; Region: B; pfam02216 1118959000291 B domain; Region: B; pfam02216 1118959000292 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1118959000293 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959000294 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1118959000295 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959000296 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1118959000297 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1118959000298 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959000299 ABC-ATPase subunit interface; other site 1118959000300 dimer interface [polypeptide binding]; other site 1118959000301 putative PBP binding regions; other site 1118959000302 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1118959000303 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959000304 ABC-ATPase subunit interface; other site 1118959000305 dimer interface [polypeptide binding]; other site 1118959000306 putative PBP binding regions; other site 1118959000307 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1118959000308 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1118959000309 siderophore binding site; other site 1118959000310 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1118959000311 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1118959000312 dimer interface [polypeptide binding]; other site 1118959000313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959000314 catalytic residue [active] 1118959000315 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1118959000316 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1118959000317 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1118959000318 IucA / IucC family; Region: IucA_IucC; pfam04183 1118959000319 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1118959000320 drug efflux system protein MdtG; Provisional; Region: PRK09874 1118959000321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959000322 putative substrate translocation pore; other site 1118959000323 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1118959000324 IucA / IucC family; Region: IucA_IucC; pfam04183 1118959000325 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1118959000326 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1118959000327 IucA / IucC family; Region: IucA_IucC; pfam04183 1118959000328 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1118959000329 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1118959000330 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1118959000331 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1118959000332 dimer interface [polypeptide binding]; other site 1118959000333 active site 1118959000334 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1118959000335 catalytic residues [active] 1118959000336 substrate binding site [chemical binding]; other site 1118959000337 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1118959000338 ParB-like nuclease domain; Region: ParBc; pfam02195 1118959000339 acetoin reductase; Validated; Region: PRK08643 1118959000340 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1118959000341 NAD binding site [chemical binding]; other site 1118959000342 homotetramer interface [polypeptide binding]; other site 1118959000343 homodimer interface [polypeptide binding]; other site 1118959000344 active site 1118959000345 substrate binding site [chemical binding]; other site 1118959000346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1118959000347 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1118959000348 NAD(P) binding site [chemical binding]; other site 1118959000349 active site 1118959000350 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1118959000351 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1118959000352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1118959000353 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1118959000354 putative ADP-binding pocket [chemical binding]; other site 1118959000355 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1118959000356 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1118959000357 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1118959000358 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1118959000359 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1118959000360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1118959000361 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959000362 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1118959000363 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959000364 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1118959000365 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1118959000366 DNA-binding site [nucleotide binding]; DNA binding site 1118959000367 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1118959000368 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1118959000369 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1118959000370 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1118959000371 intersubunit interface [polypeptide binding]; other site 1118959000372 active site 1118959000373 catalytic residue [active] 1118959000374 phosphopentomutase; Provisional; Region: PRK05362 1118959000375 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1118959000376 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1118959000377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959000378 dimer interface [polypeptide binding]; other site 1118959000379 conserved gate region; other site 1118959000380 putative PBP binding loops; other site 1118959000381 ABC-ATPase subunit interface; other site 1118959000382 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1118959000383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959000384 dimer interface [polypeptide binding]; other site 1118959000385 conserved gate region; other site 1118959000386 ABC-ATPase subunit interface; other site 1118959000387 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1118959000388 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1118959000389 Walker A/P-loop; other site 1118959000390 ATP binding site [chemical binding]; other site 1118959000391 Q-loop/lid; other site 1118959000392 ABC transporter signature motif; other site 1118959000393 Walker B; other site 1118959000394 D-loop; other site 1118959000395 H-loop/switch region; other site 1118959000396 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1118959000397 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1118959000398 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1118959000399 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1118959000400 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1118959000401 active site 1118959000402 metal binding site [ion binding]; metal-binding site 1118959000403 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1118959000404 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1118959000405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959000406 non-specific DNA binding site [nucleotide binding]; other site 1118959000407 salt bridge; other site 1118959000408 sequence-specific DNA binding site [nucleotide binding]; other site 1118959000409 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1118959000410 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1118959000411 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1118959000412 putative catalytic cysteine [active] 1118959000413 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1118959000414 putative active site [active] 1118959000415 metal binding site [ion binding]; metal-binding site 1118959000416 truncated capsular polysaccharide synthesisenzyme Cap5A 1118959000417 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1118959000418 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1118959000419 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1118959000420 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1118959000421 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1118959000422 NAD(P) binding site [chemical binding]; other site 1118959000423 homodimer interface [polypeptide binding]; other site 1118959000424 substrate binding site [chemical binding]; other site 1118959000425 active site 1118959000426 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1118959000427 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1118959000428 NAD(P) binding site [chemical binding]; other site 1118959000429 homodimer interface [polypeptide binding]; other site 1118959000430 substrate binding site [chemical binding]; other site 1118959000431 active site 1118959000432 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1118959000433 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1118959000434 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1118959000435 putative NAD(P) binding site [chemical binding]; other site 1118959000436 active site 1118959000437 putative substrate binding site [chemical binding]; other site 1118959000438 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1118959000439 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1118959000440 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1118959000441 active site 1118959000442 homodimer interface [polypeptide binding]; other site 1118959000443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1118959000444 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1118959000445 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1118959000446 trimer interface [polypeptide binding]; other site 1118959000447 active site 1118959000448 substrate binding site [chemical binding]; other site 1118959000449 CoA binding site [chemical binding]; other site 1118959000450 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1118959000451 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1118959000452 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1118959000453 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1118959000454 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1118959000455 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1118959000456 putative NAD(P) binding site [chemical binding]; other site 1118959000457 active site 1118959000458 putative substrate binding site [chemical binding]; other site 1118959000459 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1118959000460 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1118959000461 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1118959000462 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1118959000463 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1118959000464 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1118959000465 active site 1118959000466 homodimer interface [polypeptide binding]; other site 1118959000467 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 1118959000468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1118959000469 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 1118959000470 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1118959000471 NAD(P) binding site [chemical binding]; other site 1118959000472 catalytic residues [active] 1118959000473 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1118959000474 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1118959000475 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1118959000476 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1118959000477 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1118959000478 Walker A/P-loop; other site 1118959000479 ATP binding site [chemical binding]; other site 1118959000480 Q-loop/lid; other site 1118959000481 ABC transporter signature motif; other site 1118959000482 Walker B; other site 1118959000483 D-loop; other site 1118959000484 H-loop/switch region; other site 1118959000485 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1118959000486 NMT1-like family; Region: NMT1_2; pfam13379 1118959000487 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1118959000488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1118959000489 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1118959000490 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1118959000491 active site 1118959000492 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1118959000493 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1118959000494 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1118959000495 acyl-activating enzyme (AAE) consensus motif; other site 1118959000496 AMP binding site [chemical binding]; other site 1118959000497 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1118959000498 Condensation domain; Region: Condensation; pfam00668 1118959000499 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1118959000500 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1118959000501 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1118959000502 acyl-activating enzyme (AAE) consensus motif; other site 1118959000503 AMP binding site [chemical binding]; other site 1118959000504 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1118959000505 thioester reductase domain; Region: Thioester-redct; TIGR01746 1118959000506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1118959000507 NAD(P) binding site [chemical binding]; other site 1118959000508 active site 1118959000509 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1118959000510 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1118959000511 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1118959000512 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1118959000513 nucleotide binding site [chemical binding]; other site 1118959000514 N-acetyl-L-glutamate binding site [chemical binding]; other site 1118959000515 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1118959000516 heterotetramer interface [polypeptide binding]; other site 1118959000517 active site pocket [active] 1118959000518 cleavage site 1118959000519 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1118959000520 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1118959000521 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1118959000522 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1118959000523 inhibitor-cofactor binding pocket; inhibition site 1118959000524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959000525 catalytic residue [active] 1118959000526 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1118959000527 Isochorismatase family; Region: Isochorismatase; pfam00857 1118959000528 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1118959000529 catalytic triad [active] 1118959000530 conserved cis-peptide bond; other site 1118959000531 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1118959000532 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1118959000533 dimer interface [polypeptide binding]; other site 1118959000534 PYR/PP interface [polypeptide binding]; other site 1118959000535 TPP binding site [chemical binding]; other site 1118959000536 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1118959000537 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1118959000538 TPP-binding site [chemical binding]; other site 1118959000539 dimer interface [polypeptide binding]; other site 1118959000540 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1118959000541 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1118959000542 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1118959000543 active site turn [active] 1118959000544 phosphorylation site [posttranslational modification] 1118959000545 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1118959000546 HPr interaction site; other site 1118959000547 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1118959000548 active site 1118959000549 phosphorylation site [posttranslational modification] 1118959000550 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1118959000551 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1118959000552 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 1118959000553 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1118959000554 putative active site [active] 1118959000555 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1118959000556 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1118959000557 active site turn [active] 1118959000558 phosphorylation site [posttranslational modification] 1118959000559 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1118959000560 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1118959000561 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1118959000562 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1118959000563 putative active site [active] 1118959000564 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1118959000565 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1118959000566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1118959000567 ATP binding site [chemical binding]; other site 1118959000568 putative Mg++ binding site [ion binding]; other site 1118959000569 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1118959000570 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1118959000571 Walker A/P-loop; other site 1118959000572 ATP binding site [chemical binding]; other site 1118959000573 Q-loop/lid; other site 1118959000574 ABC transporter signature motif; other site 1118959000575 Walker B; other site 1118959000576 D-loop; other site 1118959000577 H-loop/switch region; other site 1118959000578 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1118959000579 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1118959000580 Walker A/P-loop; other site 1118959000581 ATP binding site [chemical binding]; other site 1118959000582 Q-loop/lid; other site 1118959000583 ABC transporter signature motif; other site 1118959000584 Walker B; other site 1118959000585 D-loop; other site 1118959000586 H-loop/switch region; other site 1118959000587 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1118959000588 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1118959000589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959000590 dimer interface [polypeptide binding]; other site 1118959000591 conserved gate region; other site 1118959000592 putative PBP binding loops; other site 1118959000593 ABC-ATPase subunit interface; other site 1118959000594 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1118959000595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959000596 dimer interface [polypeptide binding]; other site 1118959000597 conserved gate region; other site 1118959000598 ABC-ATPase subunit interface; other site 1118959000599 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1118959000600 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1118959000601 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1118959000602 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1118959000603 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1118959000604 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 1118959000605 azoreductase; Reviewed; Region: PRK00170 1118959000606 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1118959000607 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1118959000608 Peptidase family M23; Region: Peptidase_M23; pfam01551 1118959000609 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1118959000610 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1118959000611 Walker A/P-loop; other site 1118959000612 ATP binding site [chemical binding]; other site 1118959000613 Q-loop/lid; other site 1118959000614 ABC transporter signature motif; other site 1118959000615 Walker B; other site 1118959000616 D-loop; other site 1118959000617 H-loop/switch region; other site 1118959000618 TOBE domain; Region: TOBE; pfam03459 1118959000619 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1118959000620 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1118959000621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959000622 dimer interface [polypeptide binding]; other site 1118959000623 conserved gate region; other site 1118959000624 ABC-ATPase subunit interface; other site 1118959000625 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1118959000626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959000627 dimer interface [polypeptide binding]; other site 1118959000628 conserved gate region; other site 1118959000629 putative PBP binding loops; other site 1118959000630 ABC-ATPase subunit interface; other site 1118959000631 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1118959000632 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1118959000633 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1118959000634 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1118959000635 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1118959000636 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1118959000637 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1118959000638 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1118959000639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1118959000640 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1118959000641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959000642 putative substrate translocation pore; other site 1118959000643 Response regulator receiver domain; Region: Response_reg; pfam00072 1118959000644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959000645 active site 1118959000646 phosphorylation site [posttranslational modification] 1118959000647 intermolecular recognition site; other site 1118959000648 dimerization interface [polypeptide binding]; other site 1118959000649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1118959000650 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1118959000651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1118959000652 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1118959000653 Histidine kinase; Region: His_kinase; pfam06580 1118959000654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959000655 ATP binding site [chemical binding]; other site 1118959000656 Mg2+ binding site [ion binding]; other site 1118959000657 G-X-G motif; other site 1118959000658 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1118959000659 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1118959000660 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1118959000661 Pyruvate formate lyase 1; Region: PFL1; cd01678 1118959000662 coenzyme A binding site [chemical binding]; other site 1118959000663 active site 1118959000664 catalytic residues [active] 1118959000665 glycine loop; other site 1118959000666 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1118959000667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1118959000668 FeS/SAM binding site; other site 1118959000669 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1118959000670 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1118959000671 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1118959000672 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1118959000673 putative active site [active] 1118959000674 catalytic site [active] 1118959000675 putative metal binding site [ion binding]; other site 1118959000676 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1118959000677 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1118959000678 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1118959000679 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1118959000680 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1118959000681 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1118959000682 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1118959000683 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1118959000684 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1118959000685 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1118959000686 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1118959000687 dimer interface [polypeptide binding]; other site 1118959000688 active site 1118959000689 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1118959000690 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1118959000691 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1118959000692 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1118959000693 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1118959000694 substrate binding site [chemical binding]; other site 1118959000695 oxyanion hole (OAH) forming residues; other site 1118959000696 trimer interface [polypeptide binding]; other site 1118959000697 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1118959000698 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1118959000699 active site 1118959000700 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1118959000701 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1118959000702 acyl-activating enzyme (AAE) consensus motif; other site 1118959000703 AMP binding site [chemical binding]; other site 1118959000704 active site 1118959000705 CoA binding site [chemical binding]; other site 1118959000706 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1118959000707 Coenzyme A transferase; Region: CoA_trans; smart00882 1118959000708 Coenzyme A transferase; Region: CoA_trans; cl17247 1118959000709 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1118959000710 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1118959000711 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1118959000712 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1118959000713 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1118959000714 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1118959000715 heme-binding site [chemical binding]; other site 1118959000716 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1118959000717 FAD binding pocket [chemical binding]; other site 1118959000718 FAD binding motif [chemical binding]; other site 1118959000719 phosphate binding motif [ion binding]; other site 1118959000720 beta-alpha-beta structure motif; other site 1118959000721 NAD binding pocket [chemical binding]; other site 1118959000722 Heme binding pocket [chemical binding]; other site 1118959000723 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1118959000724 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1118959000725 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1118959000726 NAD binding site [chemical binding]; other site 1118959000727 dimer interface [polypeptide binding]; other site 1118959000728 substrate binding site [chemical binding]; other site 1118959000729 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1118959000730 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1118959000731 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1118959000732 active site turn [active] 1118959000733 phosphorylation site [posttranslational modification] 1118959000734 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1118959000735 active site 1118959000736 tetramer interface [polypeptide binding]; other site 1118959000737 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1118959000738 Mga helix-turn-helix domain; Region: Mga; pfam05043 1118959000739 PRD domain; Region: PRD; pfam00874 1118959000740 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1118959000741 active site 1118959000742 P-loop; other site 1118959000743 phosphorylation site [posttranslational modification] 1118959000744 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1118959000745 active site 1118959000746 phosphorylation site [posttranslational modification] 1118959000747 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1118959000748 active site 1118959000749 phosphorylation site [posttranslational modification] 1118959000750 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1118959000751 active site 1118959000752 P-loop; other site 1118959000753 phosphorylation site [posttranslational modification] 1118959000754 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1118959000755 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1118959000756 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1118959000757 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1118959000758 putative NAD(P) binding site [chemical binding]; other site 1118959000759 catalytic Zn binding site [ion binding]; other site 1118959000760 structural Zn binding site [ion binding]; other site 1118959000761 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1118959000762 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1118959000763 putative NAD(P) binding site [chemical binding]; other site 1118959000764 catalytic Zn binding site [ion binding]; other site 1118959000765 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1118959000766 substrate binding site; other site 1118959000767 dimer interface; other site 1118959000768 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1118959000769 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1118959000770 NAD(P) binding site [chemical binding]; other site 1118959000771 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1118959000772 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1118959000773 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1118959000774 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1118959000775 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1118959000776 substrate binding site; other site 1118959000777 dimer interface; other site 1118959000778 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1118959000779 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1118959000780 putative NAD(P) binding site [chemical binding]; other site 1118959000781 putative catalytic Zn binding site [ion binding]; other site 1118959000782 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1118959000783 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1118959000784 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1118959000785 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1118959000786 active site 1118959000787 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 1118959000788 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1118959000789 Hemerythrin-like domain; Region: Hr-like; cd12108 1118959000790 Fe binding site [ion binding]; other site 1118959000791 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1118959000792 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1118959000793 Histidine kinase; Region: His_kinase; pfam06580 1118959000794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959000795 Mg2+ binding site [ion binding]; other site 1118959000796 G-X-G motif; other site 1118959000797 two-component response regulator; Provisional; Region: PRK14084 1118959000798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959000799 active site 1118959000800 phosphorylation site [posttranslational modification] 1118959000801 intermolecular recognition site; other site 1118959000802 dimerization interface [polypeptide binding]; other site 1118959000803 LytTr DNA-binding domain; Region: LytTR; pfam04397 1118959000804 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1118959000805 antiholin-like protein LrgB; Provisional; Region: PRK04288 1118959000806 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1118959000807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1118959000808 DNA-binding site [nucleotide binding]; DNA binding site 1118959000809 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1118959000810 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1118959000811 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1118959000812 HPr interaction site; other site 1118959000813 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1118959000814 active site 1118959000815 phosphorylation site [posttranslational modification] 1118959000816 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1118959000817 beta-galactosidase; Region: BGL; TIGR03356 1118959000818 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1118959000819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959000820 S-adenosylmethionine binding site [chemical binding]; other site 1118959000821 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1118959000822 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1118959000823 substrate binding site [chemical binding]; other site 1118959000824 dimer interface [polypeptide binding]; other site 1118959000825 ATP binding site [chemical binding]; other site 1118959000826 D-ribose pyranase; Provisional; Region: PRK11797 1118959000827 Sugar transport protein; Region: Sugar_transport; pfam06800 1118959000828 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1118959000829 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1118959000830 DNA binding site [nucleotide binding] 1118959000831 domain linker motif; other site 1118959000832 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1118959000833 dimerization interface [polypeptide binding]; other site 1118959000834 ligand binding site [chemical binding]; other site 1118959000835 Truncated NADH dehydrogenase subunit 1118959000836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959000837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959000838 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1118959000839 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1118959000840 active site 1118959000841 Surface antigen [General function prediction only]; Region: COG3942 1118959000842 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1118959000843 Peptidase family M23; Region: Peptidase_M23; pfam01551 1118959000844 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1118959000845 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1118959000846 Walker A/P-loop; other site 1118959000847 ATP binding site [chemical binding]; other site 1118959000848 Q-loop/lid; other site 1118959000849 ABC transporter signature motif; other site 1118959000850 Walker B; other site 1118959000851 D-loop; other site 1118959000852 H-loop/switch region; other site 1118959000853 Surface antigen [General function prediction only]; Region: COG3942 1118959000854 CHAP domain; Region: CHAP; pfam05257 1118959000855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1118959000856 Predicted membrane protein [Function unknown]; Region: COG1511 1118959000857 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1118959000858 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1118959000859 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1118959000860 Uncharacterized small protein [Function unknown]; Region: COG5417 1118959000861 Predicted membrane protein [Function unknown]; Region: COG4499 1118959000862 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1118959000863 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1118959000864 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1118959000865 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1118959000866 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1118959000867 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 1118959000868 LXG domain of WXG superfamily; Region: LXG; pfam04740 1118959000869 Protein of unknown function, DUF600; Region: DUF600; cl04640 1118959000870 Protein of unknown function, DUF600; Region: DUF600; cl04640 1118959000871 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 1118959000872 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1118959000873 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1118959000874 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1118959000875 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 1118959000876 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1118959000877 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1118959000878 FtsX-like permease family; Region: FtsX; pfam02687 1118959000879 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1118959000880 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1118959000881 Walker A/P-loop; other site 1118959000882 ATP binding site [chemical binding]; other site 1118959000883 Q-loop/lid; other site 1118959000884 ABC transporter signature motif; other site 1118959000885 Walker B; other site 1118959000886 D-loop; other site 1118959000887 H-loop/switch region; other site 1118959000888 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1118959000889 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1118959000890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959000891 non-specific DNA binding site [nucleotide binding]; other site 1118959000892 salt bridge; other site 1118959000893 sequence-specific DNA binding site [nucleotide binding]; other site 1118959000894 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1118959000895 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1118959000896 substrate binding site [chemical binding]; other site 1118959000897 ATP binding site [chemical binding]; other site 1118959000898 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1118959000899 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1118959000900 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1118959000901 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1118959000902 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1118959000903 putative transporter; Provisional; Region: PRK10484 1118959000904 Na binding site [ion binding]; other site 1118959000905 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1118959000906 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1118959000907 inhibitor site; inhibition site 1118959000908 active site 1118959000909 dimer interface [polypeptide binding]; other site 1118959000910 catalytic residue [active] 1118959000911 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1118959000912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1118959000913 nucleotide binding site [chemical binding]; other site 1118959000914 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1118959000915 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1118959000916 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1118959000917 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1118959000918 putative active site [active] 1118959000919 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1118959000920 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1118959000921 putative active site cavity [active] 1118959000922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1118959000923 Nucleoside recognition; Region: Gate; pfam07670 1118959000924 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1118959000925 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1118959000926 PGAP1-like protein; Region: PGAP1; pfam07819 1118959000927 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1118959000928 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1118959000929 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1118959000930 putative active site [active] 1118959000931 putative FMN binding site [chemical binding]; other site 1118959000932 putative substrate binding site [chemical binding]; other site 1118959000933 putative catalytic residue [active] 1118959000934 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1118959000935 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1118959000936 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1118959000937 lipoyl attachment site [posttranslational modification]; other site 1118959000938 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1118959000939 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1118959000940 putative ADP-ribose binding site [chemical binding]; other site 1118959000941 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1118959000942 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1118959000943 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1118959000944 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1118959000945 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1118959000946 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1118959000947 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1118959000948 active site 1118959000949 P-loop; other site 1118959000950 phosphorylation site [posttranslational modification] 1118959000951 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1118959000952 active site 1118959000953 phosphorylation site [posttranslational modification] 1118959000954 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1118959000955 HTH domain; Region: HTH_11; pfam08279 1118959000956 HTH domain; Region: HTH_11; pfam08279 1118959000957 PRD domain; Region: PRD; pfam00874 1118959000958 PRD domain; Region: PRD; pfam00874 1118959000959 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1118959000960 active site 1118959000961 P-loop; other site 1118959000962 phosphorylation site [posttranslational modification] 1118959000963 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1118959000964 active site 1118959000965 phosphorylation site [posttranslational modification] 1118959000966 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1118959000967 MarR family; Region: MarR_2; pfam12802 1118959000968 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1118959000969 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1118959000970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 1118959000971 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1118959000972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959000973 putative substrate translocation pore; other site 1118959000974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959000975 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1118959000976 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1118959000977 Zn binding site [ion binding]; other site 1118959000978 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1118959000979 Zn binding site [ion binding]; other site 1118959000980 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1118959000981 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1118959000982 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1118959000983 Predicted flavoprotein [General function prediction only]; Region: COG0431 1118959000984 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1118959000985 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1118959000986 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1118959000987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1118959000988 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1118959000989 Imelysin; Region: Peptidase_M75; pfam09375 1118959000990 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1118959000991 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1118959000992 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1118959000993 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1118959000994 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1118959000995 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1118959000996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959000997 non-specific DNA binding site [nucleotide binding]; other site 1118959000998 salt bridge; other site 1118959000999 sequence-specific DNA binding site [nucleotide binding]; other site 1118959001000 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1118959001001 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1118959001002 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1118959001003 Walker A/P-loop; other site 1118959001004 ATP binding site [chemical binding]; other site 1118959001005 Q-loop/lid; other site 1118959001006 ABC transporter signature motif; other site 1118959001007 Walker B; other site 1118959001008 D-loop; other site 1118959001009 H-loop/switch region; other site 1118959001010 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1118959001011 Predicted membrane protein [Function unknown]; Region: COG4292 1118959001012 putative acyltransferase; Provisional; Region: PRK05790 1118959001013 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1118959001014 dimer interface [polypeptide binding]; other site 1118959001015 active site 1118959001016 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1118959001017 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1118959001018 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1118959001019 THF binding site; other site 1118959001020 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1118959001021 substrate binding site [chemical binding]; other site 1118959001022 THF binding site; other site 1118959001023 zinc-binding site [ion binding]; other site 1118959001024 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1118959001025 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1118959001026 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1118959001027 FAD binding site [chemical binding]; other site 1118959001028 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1118959001029 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1118959001030 homodimer interface [polypeptide binding]; other site 1118959001031 substrate-cofactor binding pocket; other site 1118959001032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959001033 catalytic residue [active] 1118959001034 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1118959001035 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1118959001036 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1118959001037 catalytic residue [active] 1118959001038 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1118959001039 ParB-like nuclease domain; Region: ParB; smart00470 1118959001040 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1118959001041 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1118959001042 GTP-binding protein YchF; Reviewed; Region: PRK09601 1118959001043 YchF GTPase; Region: YchF; cd01900 1118959001044 G1 box; other site 1118959001045 GTP/Mg2+ binding site [chemical binding]; other site 1118959001046 Switch I region; other site 1118959001047 G2 box; other site 1118959001048 Switch II region; other site 1118959001049 G3 box; other site 1118959001050 G4 box; other site 1118959001051 G5 box; other site 1118959001052 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1118959001053 Winged helix-turn helix; Region: HTH_29; pfam13551 1118959001054 Integrase core domain; Region: rve; pfam00665 1118959001055 transposase/IS protein; Provisional; Region: PRK09183 1118959001056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959001057 Walker A motif; other site 1118959001058 ATP binding site [chemical binding]; other site 1118959001059 Walker B motif; other site 1118959001060 arginine finger; other site 1118959001061 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1118959001062 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1118959001063 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1118959001064 dimer interface [polypeptide binding]; other site 1118959001065 ssDNA binding site [nucleotide binding]; other site 1118959001066 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1118959001067 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1118959001068 Abi-like protein; Region: Abi_2; pfam07751 1118959001069 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1118959001071 Predicted membrane protein [Function unknown]; Region: COG3212 1118959001072 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1118959001073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1118959001074 non-specific DNA binding site [nucleotide binding]; other site 1118959001075 salt bridge; other site 1118959001076 sequence-specific DNA binding site [nucleotide binding]; other site 1118959001077 Predicted membrane protein [Function unknown]; Region: COG2261 1118959001078 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1118959001079 catalytic core [active] 1118959001080 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1118959001081 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1118959001082 catalytic residue [active] 1118959001083 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1118959001084 catalytic residues [active] 1118959001085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1118959001086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959001087 peroxiredoxin; Region: AhpC; TIGR03137 1118959001088 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1118959001089 dimer interface [polypeptide binding]; other site 1118959001090 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1118959001091 catalytic triad [active] 1118959001092 peroxidatic and resolving cysteines [active] 1118959001093 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1118959001094 dimer interface [polypeptide binding]; other site 1118959001095 NADPH bind site [chemical binding]; other site 1118959001096 FMN binding site [chemical binding]; other site 1118959001097 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1118959001098 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1118959001099 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1118959001100 active site 1118959001101 xanthine permease; Region: pbuX; TIGR03173 1118959001102 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1118959001103 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1118959001104 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1118959001105 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1118959001106 active site 1118959001107 GMP synthase; Reviewed; Region: guaA; PRK00074 1118959001108 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1118959001109 AMP/PPi binding site [chemical binding]; other site 1118959001110 candidate oxyanion hole; other site 1118959001111 catalytic triad [active] 1118959001112 potential glutamine specificity residues [chemical binding]; other site 1118959001113 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1118959001114 ATP Binding subdomain [chemical binding]; other site 1118959001115 Ligand Binding sites [chemical binding]; other site 1118959001116 Dimerization subdomain; other site 1118959001117 genomic island 1118959001118 Abi-like protein; Region: Abi_2; pfam07751 1118959001119 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1118959001120 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1118959001121 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1118959001122 Divergent AAA domain; Region: AAA_4; pfam04326 1118959001123 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1118959001124 Predicted membrane protein [Function unknown]; Region: COG3759 1118959001125 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1118959001126 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1118959001127 NADP binding site [chemical binding]; other site 1118959001128 superantigen-like protein; Reviewed; Region: PRK13037 1118959001129 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1118959001130 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001131 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1118959001132 superantigen-like protein; Reviewed; Region: PRK13041 1118959001133 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1118959001134 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001135 superantigen-like protein; Reviewed; Region: PRK13335 1118959001136 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1118959001137 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001138 superantigen-like protein; Reviewed; Region: PRK13042 1118959001139 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1118959001140 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001141 superantigen-like protein 5; Reviewed; Region: PRK13035 1118959001142 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1118959001143 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001144 superantigen-like protein 7; Reviewed; Region: PRK13346 1118959001145 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1118959001146 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001147 superantigen-like protein; Reviewed; Region: PRK13039 1118959001148 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1118959001149 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001150 superantigen-like protein; Reviewed; Region: PRK13345 1118959001151 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1118959001152 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001153 superantigen-like protein; Reviewed; Region: PRK13038 1118959001154 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1118959001155 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001156 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1118959001157 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1118959001158 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1118959001159 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1118959001160 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1118959001161 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1118959001162 superantigen-like protein; Reviewed; Region: PRK13036 1118959001163 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1118959001164 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959001165 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1118959001166 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1118959001167 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1118959001168 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959001169 transposase/IS protein; Provisional; Region: PRK09183 1118959001170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959001171 Walker A motif; other site 1118959001172 ATP binding site [chemical binding]; other site 1118959001173 Walker B motif; other site 1118959001174 arginine finger; other site 1118959001175 Winged helix-turn helix; Region: HTH_29; pfam13551 1118959001176 Integrase core domain; Region: rve; pfam00665 1118959001177 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1118959001178 potential frameshift: common BLAST hit: gi|151220620|ref|YP_001331442.1| tandem lipoprotein 1118959001179 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959001180 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959001181 potential frameshift: common BLAST hit: gi|87160391|ref|YP_493129.1| tandem lipoprotein 1118959001182 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959001183 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959001184 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1118959001185 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1118959001186 nucleophilic elbow; other site 1118959001187 catalytic triad; other site 1118959001188 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1118959001189 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1118959001190 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1118959001191 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1118959001192 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1118959001193 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1118959001194 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1118959001195 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1118959001196 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1118959001197 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1118959001198 active site 1118959001199 Esterase/lipase [General function prediction only]; Region: COG1647 1118959001200 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1118959001201 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1118959001202 Na2 binding site [ion binding]; other site 1118959001203 putative substrate binding site 1 [chemical binding]; other site 1118959001204 Na binding site 1 [ion binding]; other site 1118959001205 putative substrate binding site 2 [chemical binding]; other site 1118959001206 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1118959001207 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1118959001208 dimer interface [polypeptide binding]; other site 1118959001209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959001210 catalytic residue [active] 1118959001211 cystathionine beta-lyase; Provisional; Region: PRK07671 1118959001212 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1118959001213 homodimer interface [polypeptide binding]; other site 1118959001214 substrate-cofactor binding pocket; other site 1118959001215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959001216 catalytic residue [active] 1118959001217 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1118959001218 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1118959001219 Walker A/P-loop; other site 1118959001220 ATP binding site [chemical binding]; other site 1118959001221 Q-loop/lid; other site 1118959001222 ABC transporter signature motif; other site 1118959001223 Walker B; other site 1118959001224 D-loop; other site 1118959001225 H-loop/switch region; other site 1118959001226 NIL domain; Region: NIL; pfam09383 1118959001227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959001228 dimer interface [polypeptide binding]; other site 1118959001229 conserved gate region; other site 1118959001230 ABC-ATPase subunit interface; other site 1118959001231 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1118959001232 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1118959001233 LysM domain; Region: LysM; pfam01476 1118959001234 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1118959001235 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1118959001236 Surface antigen [General function prediction only]; Region: COG3942 1118959001237 CHAP domain; Region: CHAP; pfam05257 1118959001238 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1118959001239 nudix motif; other site 1118959001240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959001241 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1118959001242 Coenzyme A binding pocket [chemical binding]; other site 1118959001243 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1118959001244 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1118959001245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1118959001246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1118959001247 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1118959001248 dimerization interface [polypeptide binding]; other site 1118959001249 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1118959001250 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1118959001251 active site 1118959001252 dimer interface [polypeptide binding]; other site 1118959001253 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1118959001254 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1118959001255 active site 1118959001256 FMN binding site [chemical binding]; other site 1118959001257 substrate binding site [chemical binding]; other site 1118959001258 3Fe-4S cluster binding site [ion binding]; other site 1118959001259 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1118959001260 domain interface; other site 1118959001261 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1118959001262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1118959001263 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1118959001264 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1118959001265 active site turn [active] 1118959001266 phosphorylation site [posttranslational modification] 1118959001267 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1118959001268 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1118959001269 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1118959001270 Ca binding site [ion binding]; other site 1118959001271 active site 1118959001272 catalytic site [active] 1118959001273 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1118959001274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1118959001275 DNA-binding site [nucleotide binding]; DNA binding site 1118959001276 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1118959001277 UTRA domain; Region: UTRA; pfam07702 1118959001278 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1118959001279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959001280 Coenzyme A binding pocket [chemical binding]; other site 1118959001281 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1118959001282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959001283 Walker A motif; other site 1118959001284 ATP binding site [chemical binding]; other site 1118959001285 Walker B motif; other site 1118959001286 arginine finger; other site 1118959001287 hypothetical protein; Validated; Region: PRK00153 1118959001288 recombination protein RecR; Reviewed; Region: recR; PRK00076 1118959001289 RecR protein; Region: RecR; pfam02132 1118959001290 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1118959001291 putative active site [active] 1118959001292 putative metal-binding site [ion binding]; other site 1118959001293 tetramer interface [polypeptide binding]; other site 1118959001294 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1118959001295 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1118959001296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1118959001297 catalytic residue [active] 1118959001298 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1118959001299 thymidylate kinase; Validated; Region: tmk; PRK00698 1118959001300 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1118959001301 TMP-binding site; other site 1118959001302 ATP-binding site [chemical binding]; other site 1118959001303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1118959001304 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1118959001305 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1118959001306 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1118959001307 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1118959001308 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1118959001309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959001310 S-adenosylmethionine binding site [chemical binding]; other site 1118959001311 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1118959001312 GIY-YIG motif/motif A; other site 1118959001313 putative active site [active] 1118959001314 putative metal binding site [ion binding]; other site 1118959001315 Predicted methyltransferases [General function prediction only]; Region: COG0313 1118959001316 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1118959001317 putative SAM binding site [chemical binding]; other site 1118959001318 putative homodimer interface [polypeptide binding]; other site 1118959001319 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1118959001320 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1118959001321 active site 1118959001322 HIGH motif; other site 1118959001323 KMSKS motif; other site 1118959001324 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1118959001325 tRNA binding surface [nucleotide binding]; other site 1118959001326 anticodon binding site; other site 1118959001327 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1118959001328 dimer interface [polypeptide binding]; other site 1118959001329 putative tRNA-binding site [nucleotide binding]; other site 1118959001330 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1118959001331 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1118959001332 active site 1118959001333 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1118959001334 putative active site [active] 1118959001335 putative metal binding site [ion binding]; other site 1118959001336 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1118959001337 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1118959001338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959001339 S-adenosylmethionine binding site [chemical binding]; other site 1118959001340 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1118959001341 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1118959001342 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1118959001343 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1118959001344 pur operon repressor; Provisional; Region: PRK09213 1118959001345 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1118959001346 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1118959001347 active site 1118959001348 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1118959001349 homotrimer interaction site [polypeptide binding]; other site 1118959001350 putative active site [active] 1118959001351 regulatory protein SpoVG; Reviewed; Region: PRK13259 1118959001352 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1118959001353 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1118959001354 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1118959001355 Substrate binding site; other site 1118959001356 Mg++ binding site; other site 1118959001357 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1118959001358 active site 1118959001359 substrate binding site [chemical binding]; other site 1118959001360 CoA binding site [chemical binding]; other site 1118959001361 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1118959001362 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1118959001363 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1118959001364 active site 1118959001365 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1118959001366 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1118959001367 5S rRNA interface [nucleotide binding]; other site 1118959001368 CTC domain interface [polypeptide binding]; other site 1118959001369 L16 interface [polypeptide binding]; other site 1118959001370 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1118959001371 putative active site [active] 1118959001372 catalytic residue [active] 1118959001373 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1118959001374 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1118959001375 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1118959001376 ATP binding site [chemical binding]; other site 1118959001377 putative Mg++ binding site [ion binding]; other site 1118959001378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1118959001379 nucleotide binding region [chemical binding]; other site 1118959001380 ATP-binding site [chemical binding]; other site 1118959001381 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1118959001382 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1118959001383 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1118959001384 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1118959001385 putative SAM binding site [chemical binding]; other site 1118959001386 putative homodimer interface [polypeptide binding]; other site 1118959001387 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1118959001388 homodimer interface [polypeptide binding]; other site 1118959001389 metal binding site [ion binding]; metal-binding site 1118959001390 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1118959001391 RNA binding surface [nucleotide binding]; other site 1118959001392 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1118959001393 Septum formation initiator; Region: DivIC; pfam04977 1118959001394 hypothetical protein; Provisional; Region: PRK08582 1118959001395 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1118959001396 RNA binding site [nucleotide binding]; other site 1118959001397 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1118959001398 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1118959001399 Ligand Binding Site [chemical binding]; other site 1118959001400 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1118959001401 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1118959001402 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1118959001403 active site 1118959001404 FtsH Extracellular; Region: FtsH_ext; pfam06480 1118959001405 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1118959001406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959001407 Walker A motif; other site 1118959001408 ATP binding site [chemical binding]; other site 1118959001409 Walker B motif; other site 1118959001410 arginine finger; other site 1118959001411 Peptidase family M41; Region: Peptidase_M41; pfam01434 1118959001412 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1118959001413 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1118959001414 dimerization interface [polypeptide binding]; other site 1118959001415 domain crossover interface; other site 1118959001416 redox-dependent activation switch; other site 1118959001417 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1118959001418 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1118959001419 dimer interface [polypeptide binding]; other site 1118959001420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959001421 catalytic residue [active] 1118959001422 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1118959001423 dihydropteroate synthase; Region: DHPS; TIGR01496 1118959001424 substrate binding pocket [chemical binding]; other site 1118959001425 dimer interface [polypeptide binding]; other site 1118959001426 inhibitor binding site; inhibition site 1118959001427 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1118959001428 homooctamer interface [polypeptide binding]; other site 1118959001429 active site 1118959001430 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1118959001431 catalytic center binding site [active] 1118959001432 ATP binding site [chemical binding]; other site 1118959001433 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1118959001434 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1118959001435 dimer interface [polypeptide binding]; other site 1118959001436 putative anticodon binding site; other site 1118959001437 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1118959001438 motif 1; other site 1118959001439 active site 1118959001440 motif 2; other site 1118959001441 motif 3; other site 1118959001442 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1118959001443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1118959001444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959001445 homodimer interface [polypeptide binding]; other site 1118959001446 catalytic residue [active] 1118959001447 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1118959001448 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1118959001449 active site 1118959001450 multimer interface [polypeptide binding]; other site 1118959001451 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1118959001452 predicted active site [active] 1118959001453 catalytic triad [active] 1118959001454 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1118959001455 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1118959001456 Nucleoside recognition; Region: Gate; pfam07670 1118959001457 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1118959001458 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1118959001459 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1118959001460 UvrB/uvrC motif; Region: UVR; pfam02151 1118959001461 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1118959001462 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1118959001463 ADP binding site [chemical binding]; other site 1118959001464 phosphagen binding site; other site 1118959001465 substrate specificity loop; other site 1118959001466 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1118959001467 Clp amino terminal domain; Region: Clp_N; pfam02861 1118959001468 Clp amino terminal domain; Region: Clp_N; pfam02861 1118959001469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959001470 Walker A motif; other site 1118959001471 ATP binding site [chemical binding]; other site 1118959001472 Walker B motif; other site 1118959001473 arginine finger; other site 1118959001474 UvrB/uvrC motif; Region: UVR; pfam02151 1118959001475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959001476 Walker A motif; other site 1118959001477 ATP binding site [chemical binding]; other site 1118959001478 Walker B motif; other site 1118959001479 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1118959001480 DNA repair protein RadA; Provisional; Region: PRK11823 1118959001481 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1118959001482 Walker A motif/ATP binding site; other site 1118959001483 ATP binding site [chemical binding]; other site 1118959001484 Walker B motif; other site 1118959001485 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1118959001486 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1118959001487 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1118959001488 putative active site [active] 1118959001489 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1118959001490 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1118959001491 active site 1118959001492 HIGH motif; other site 1118959001493 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1118959001494 active site 1118959001495 KMSKS motif; other site 1118959001496 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1118959001497 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1118959001498 trimer interface [polypeptide binding]; other site 1118959001499 active site 1118959001500 substrate binding site [chemical binding]; other site 1118959001501 CoA binding site [chemical binding]; other site 1118959001502 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1118959001503 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1118959001504 active site 1118959001505 HIGH motif; other site 1118959001506 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1118959001507 KMSKS motif; other site 1118959001508 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1118959001509 tRNA binding surface [nucleotide binding]; other site 1118959001510 anticodon binding site; other site 1118959001511 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1118959001512 active site 1118959001513 dimerization interface [polypeptide binding]; other site 1118959001514 metal binding site [ion binding]; metal-binding site 1118959001515 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1118959001516 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1118959001517 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1118959001518 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1118959001519 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1118959001520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1118959001521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1118959001522 DNA binding residues [nucleotide binding] 1118959001523 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1118959001524 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1118959001525 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1118959001526 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1118959001527 putative homodimer interface [polypeptide binding]; other site 1118959001528 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1118959001529 heterodimer interface [polypeptide binding]; other site 1118959001530 homodimer interface [polypeptide binding]; other site 1118959001531 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1118959001532 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1118959001533 23S rRNA interface [nucleotide binding]; other site 1118959001534 L7/L12 interface [polypeptide binding]; other site 1118959001535 putative thiostrepton binding site; other site 1118959001536 L25 interface [polypeptide binding]; other site 1118959001537 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1118959001538 mRNA/rRNA interface [nucleotide binding]; other site 1118959001539 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1118959001540 23S rRNA interface [nucleotide binding]; other site 1118959001541 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1118959001542 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1118959001543 peripheral dimer interface [polypeptide binding]; other site 1118959001544 core dimer interface [polypeptide binding]; other site 1118959001545 L10 interface [polypeptide binding]; other site 1118959001546 L11 interface [polypeptide binding]; other site 1118959001547 putative EF-Tu interaction site [polypeptide binding]; other site 1118959001548 putative EF-G interaction site [polypeptide binding]; other site 1118959001549 potential frameshift: common BLAST hit: gi|87161944|ref|YP_493229.1| methyltransferase small subunit 1118959001550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1118959001551 S-adenosylmethionine binding site [chemical binding]; other site 1118959001552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1118959001553 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1118959001554 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1118959001555 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1118959001556 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1118959001557 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1118959001558 RPB10 interaction site [polypeptide binding]; other site 1118959001559 RPB1 interaction site [polypeptide binding]; other site 1118959001560 RPB11 interaction site [polypeptide binding]; other site 1118959001561 RPB3 interaction site [polypeptide binding]; other site 1118959001562 RPB12 interaction site [polypeptide binding]; other site 1118959001563 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1118959001564 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1118959001565 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1118959001566 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1118959001567 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1118959001568 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1118959001569 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1118959001570 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1118959001571 G-loop; other site 1118959001572 DNA binding site [nucleotide binding] 1118959001573 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 1118959001574 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1118959001575 S17 interaction site [polypeptide binding]; other site 1118959001576 S8 interaction site; other site 1118959001577 16S rRNA interaction site [nucleotide binding]; other site 1118959001578 streptomycin interaction site [chemical binding]; other site 1118959001579 23S rRNA interaction site [nucleotide binding]; other site 1118959001580 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1118959001581 30S ribosomal protein S7; Validated; Region: PRK05302 1118959001582 elongation factor G; Reviewed; Region: PRK00007 1118959001583 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1118959001584 G1 box; other site 1118959001585 putative GEF interaction site [polypeptide binding]; other site 1118959001586 GTP/Mg2+ binding site [chemical binding]; other site 1118959001587 Switch I region; other site 1118959001588 G2 box; other site 1118959001589 G3 box; other site 1118959001590 Switch II region; other site 1118959001591 G4 box; other site 1118959001592 G5 box; other site 1118959001593 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1118959001594 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1118959001595 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1118959001596 elongation factor Tu; Reviewed; Region: PRK00049 1118959001597 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1118959001598 G1 box; other site 1118959001599 GEF interaction site [polypeptide binding]; other site 1118959001600 GTP/Mg2+ binding site [chemical binding]; other site 1118959001601 Switch I region; other site 1118959001602 G2 box; other site 1118959001603 G3 box; other site 1118959001604 Switch II region; other site 1118959001605 G4 box; other site 1118959001606 G5 box; other site 1118959001607 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1118959001608 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1118959001609 Antibiotic Binding Site [chemical binding]; other site 1118959001610 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1118959001611 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1118959001612 metal binding site [ion binding]; metal-binding site 1118959001613 dimer interface [polypeptide binding]; other site 1118959001614 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1118959001615 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1118959001616 substrate-cofactor binding pocket; other site 1118959001617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959001618 catalytic residue [active] 1118959001619 chaperone protein HchA; Provisional; Region: PRK04155 1118959001620 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1118959001621 conserved cys residue [active] 1118959001622 ribulokinase; Provisional; Region: PRK04123 1118959001623 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1118959001624 N- and C-terminal domain interface [polypeptide binding]; other site 1118959001625 active site 1118959001626 MgATP binding site [chemical binding]; other site 1118959001627 catalytic site [active] 1118959001628 metal binding site [ion binding]; metal-binding site 1118959001629 carbohydrate binding site [chemical binding]; other site 1118959001630 homodimer interface [polypeptide binding]; other site 1118959001631 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1118959001632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1118959001633 NAD(P) binding site [chemical binding]; other site 1118959001634 active site 1118959001635 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1118959001636 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1118959001637 homodimer interface [polypeptide binding]; other site 1118959001638 substrate-cofactor binding pocket; other site 1118959001639 catalytic residue [active] 1118959001640 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1118959001641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959001642 motif II; other site 1118959001643 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1118959001644 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1118959001645 Substrate-binding site [chemical binding]; other site 1118959001646 Substrate specificity [chemical binding]; other site 1118959001647 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1118959001648 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1118959001649 Substrate-binding site [chemical binding]; other site 1118959001650 Substrate specificity [chemical binding]; other site 1118959001651 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1118959001652 nucleoside/Zn binding site; other site 1118959001653 dimer interface [polypeptide binding]; other site 1118959001654 catalytic motif [active] 1118959001655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959001656 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1118959001657 active site 1118959001658 motif I; other site 1118959001659 motif II; other site 1118959001660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959001661 Predicted flavoprotein [General function prediction only]; Region: COG0431 1118959001662 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1118959001663 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1118959001664 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1118959001665 Cna protein B-type domain; Region: Cna_B; pfam05738 1118959001666 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1118959001667 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1118959001668 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1118959001669 Cna protein B-type domain; Region: Cna_B; pfam05738 1118959001670 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1118959001671 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1118959001672 Cna protein B-type domain; Region: Cna_B; pfam05738 1118959001673 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1118959001674 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1118959001675 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1118959001676 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1118959001677 Cna protein B-type domain; Region: Cna_B; pfam05738 1118959001678 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1118959001679 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1118959001680 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1118959001681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1118959001682 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1118959001683 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1118959001684 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1118959001685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1118959001686 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959001687 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1118959001688 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959001689 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1118959001690 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1118959001691 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1118959001692 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1118959001693 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1118959001694 active site 1118959001695 trimer interface [polypeptide binding]; other site 1118959001696 allosteric site; other site 1118959001697 active site lid [active] 1118959001698 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1118959001699 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1118959001700 active site 1118959001701 dimer interface [polypeptide binding]; other site 1118959001702 magnesium binding site [ion binding]; other site 1118959001703 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1118959001704 tetramer interface [polypeptide binding]; other site 1118959001705 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1118959001706 active site 1118959001707 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1118959001708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959001709 motif II; other site 1118959001710 proline/glycine betaine transporter; Provisional; Region: PRK10642 1118959001711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959001712 putative substrate translocation pore; other site 1118959001713 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1118959001714 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1118959001715 acyl-activating enzyme (AAE) consensus motif; other site 1118959001716 AMP binding site [chemical binding]; other site 1118959001717 active site 1118959001718 CoA binding site [chemical binding]; other site 1118959001719 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1118959001720 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1118959001721 dimer interface [polypeptide binding]; other site 1118959001722 active site 1118959001723 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1118959001724 dimer interface [polypeptide binding]; other site 1118959001725 substrate binding site [chemical binding]; other site 1118959001726 ATP binding site [chemical binding]; other site 1118959001727 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1118959001728 ligand binding site [chemical binding]; other site 1118959001729 active site 1118959001730 UGI interface [polypeptide binding]; other site 1118959001731 catalytic site [active] 1118959001732 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1118959001733 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1118959001734 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1118959001735 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1118959001736 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1118959001737 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1118959001738 putative heme peroxidase; Provisional; Region: PRK12276 1118959001739 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1118959001740 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1118959001741 mevalonate kinase; Region: mevalon_kin; TIGR00549 1118959001742 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1118959001743 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1118959001744 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1118959001745 diphosphomevalonate decarboxylase; Region: PLN02407 1118959001746 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1118959001747 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1118959001748 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1118959001749 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1118959001750 Predicted transcriptional regulator [Transcription]; Region: COG1959 1118959001751 Transcriptional regulator; Region: Rrf2; pfam02082 1118959001752 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1118959001753 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1118959001754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959001755 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1118959001756 LXG domain of WXG superfamily; Region: LXG; pfam04740 1118959001757 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1118959001758 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1118959001759 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1118959001760 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1118959001761 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1118959001762 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1118959001763 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1118959001764 active site 1118959001765 catalytic tetrad [active] 1118959001766 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1118959001767 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1118959001768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1118959001769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959001770 Coenzyme A binding pocket [chemical binding]; other site 1118959001771 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1118959001772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1118959001773 Zn2+ binding site [ion binding]; other site 1118959001774 Mg2+ binding site [ion binding]; other site 1118959001775 YwhD family; Region: YwhD; pfam08741 1118959001776 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1118959001777 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1118959001778 NAD binding site [chemical binding]; other site 1118959001779 substrate binding site [chemical binding]; other site 1118959001780 catalytic Zn binding site [ion binding]; other site 1118959001781 tetramer interface [polypeptide binding]; other site 1118959001782 structural Zn binding site [ion binding]; other site 1118959001783 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1118959001784 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1118959001785 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1118959001786 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1118959001787 active site 1118959001788 HIGH motif; other site 1118959001789 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1118959001790 KMSK motif region; other site 1118959001791 tRNA binding surface [nucleotide binding]; other site 1118959001792 DALR anticodon binding domain; Region: DALR_1; smart00836 1118959001793 anticodon binding site; other site 1118959001794 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1118959001795 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1118959001796 minor groove reading motif; other site 1118959001797 helix-hairpin-helix signature motif; other site 1118959001798 substrate binding pocket [chemical binding]; other site 1118959001799 active site 1118959001800 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1118959001801 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1118959001802 putative binding site residues; other site 1118959001803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1118959001804 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1118959001805 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959001806 ABC-ATPase subunit interface; other site 1118959001807 dimer interface [polypeptide binding]; other site 1118959001808 putative PBP binding regions; other site 1118959001809 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1118959001810 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959001811 motif II; other site 1118959001812 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1118959001813 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1118959001814 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1118959001815 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1118959001816 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959001817 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1118959001818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1118959001819 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1118959001820 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1118959001821 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1118959001822 active site 1118959001823 DNA binding site [nucleotide binding] 1118959001824 Int/Topo IB signature motif; other site 1118959001825 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1118959001826 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1118959001827 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 1118959001828 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1118959001829 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1118959001830 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1118959001831 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1118959001832 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1118959001833 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1118959001834 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1118959001835 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1118959001836 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1118959001837 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1118959001838 metal binding site [ion binding]; metal-binding site 1118959001839 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1118959001840 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959001841 ABC-ATPase subunit interface; other site 1118959001842 dimer interface [polypeptide binding]; other site 1118959001843 putative PBP binding regions; other site 1118959001844 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1118959001845 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1118959001846 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1118959001847 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1118959001848 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1118959001849 FeoA domain; Region: FeoA; pfam04023 1118959001850 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1118959001851 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1118959001852 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1118959001853 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1118959001854 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1118959001855 Walker A/P-loop; other site 1118959001856 ATP binding site [chemical binding]; other site 1118959001857 Q-loop/lid; other site 1118959001858 ABC transporter signature motif; other site 1118959001859 Walker B; other site 1118959001860 D-loop; other site 1118959001861 H-loop/switch region; other site 1118959001862 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1118959001863 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1118959001864 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1118959001865 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1118959001866 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1118959001867 active site 1118959001868 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1118959001869 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1118959001870 active site 1118959001871 nucleotide binding site [chemical binding]; other site 1118959001872 HIGH motif; other site 1118959001873 KMSKS motif; other site 1118959001874 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1118959001875 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1118959001876 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1118959001877 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1118959001878 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1118959001879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959001880 Walker A/P-loop; other site 1118959001881 ATP binding site [chemical binding]; other site 1118959001882 Q-loop/lid; other site 1118959001883 ABC transporter signature motif; other site 1118959001884 Walker B; other site 1118959001885 D-loop; other site 1118959001886 H-loop/switch region; other site 1118959001887 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1118959001888 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1118959001889 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1118959001890 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1118959001891 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1118959001892 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1118959001893 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1118959001894 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1118959001895 Walker A/P-loop; other site 1118959001896 ATP binding site [chemical binding]; other site 1118959001897 Q-loop/lid; other site 1118959001898 ABC transporter signature motif; other site 1118959001899 Walker B; other site 1118959001900 D-loop; other site 1118959001901 H-loop/switch region; other site 1118959001902 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1118959001903 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959001904 ABC-ATPase subunit interface; other site 1118959001905 dimer interface [polypeptide binding]; other site 1118959001906 putative PBP binding regions; other site 1118959001907 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1118959001908 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959001909 ABC-ATPase subunit interface; other site 1118959001910 dimer interface [polypeptide binding]; other site 1118959001911 putative PBP binding regions; other site 1118959001912 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1118959001913 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1118959001914 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1118959001915 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1118959001916 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1118959001917 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1118959001918 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1118959001919 Na binding site [ion binding]; other site 1118959001920 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1118959001921 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1118959001922 substrate binding pocket [chemical binding]; other site 1118959001923 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1118959001924 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1118959001925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959001926 Coenzyme A binding pocket [chemical binding]; other site 1118959001927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1118959001928 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1118959001929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1118959001930 NAD(P) binding site [chemical binding]; other site 1118959001931 active site 1118959001932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1118959001933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959001934 active site 1118959001935 phosphorylation site [posttranslational modification] 1118959001936 intermolecular recognition site; other site 1118959001937 dimerization interface [polypeptide binding]; other site 1118959001938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1118959001939 DNA binding site [nucleotide binding] 1118959001940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1118959001941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1118959001942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959001943 ATP binding site [chemical binding]; other site 1118959001944 Mg2+ binding site [ion binding]; other site 1118959001945 G-X-G motif; other site 1118959001946 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1118959001947 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1118959001948 Walker A/P-loop; other site 1118959001949 ATP binding site [chemical binding]; other site 1118959001950 Q-loop/lid; other site 1118959001951 ABC transporter signature motif; other site 1118959001952 Walker B; other site 1118959001953 D-loop; other site 1118959001954 H-loop/switch region; other site 1118959001955 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1118959001956 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1118959001957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1118959001958 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1118959001959 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1118959001960 Surface antigen [General function prediction only]; Region: COG3942 1118959001961 CHAP domain; Region: CHAP; pfam05257 1118959001962 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1118959001963 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1118959001964 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1118959001965 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959001966 hypothetical protein; Provisional; Region: PRK12378 1118959001967 Uncharacterized conserved protein [Function unknown]; Region: COG3542 1118959001968 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1118959001969 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1118959001970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1118959001971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1118959001972 dimerization interface [polypeptide binding]; other site 1118959001973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959001974 sugar efflux transporter; Region: 2A0120; TIGR00899 1118959001975 putative substrate translocation pore; other site 1118959001976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1118959001977 Serine incorporator (Serinc); Region: Serinc; pfam03348 1118959001978 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1118959001979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959001980 Coenzyme A binding pocket [chemical binding]; other site 1118959001981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1118959001982 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1118959001983 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1118959001984 hypothetical protein; Validated; Region: PRK00124 1118959001985 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1118959001986 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1118959001987 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1118959001988 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1118959001989 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1118959001990 Walker A/P-loop; other site 1118959001991 ATP binding site [chemical binding]; other site 1118959001992 Q-loop/lid; other site 1118959001993 ABC transporter signature motif; other site 1118959001994 Walker B; other site 1118959001995 D-loop; other site 1118959001996 H-loop/switch region; other site 1118959001997 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1118959001998 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1118959001999 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1118959002000 Walker A/P-loop; other site 1118959002001 ATP binding site [chemical binding]; other site 1118959002002 Q-loop/lid; other site 1118959002003 ABC transporter signature motif; other site 1118959002004 Walker B; other site 1118959002005 D-loop; other site 1118959002006 H-loop/switch region; other site 1118959002007 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1118959002008 MarR family; Region: MarR; pfam01047 1118959002009 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1118959002010 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1118959002011 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1118959002012 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1118959002013 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1118959002014 active site 1118959002015 catalytic tetrad [active] 1118959002016 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1118959002017 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1118959002018 transmembrane helices; other site 1118959002019 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1118959002020 DNA photolyase; Region: DNA_photolyase; pfam00875 1118959002021 Predicted membrane protein [Function unknown]; Region: COG4330 1118959002022 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1118959002023 trimer interface [polypeptide binding]; other site 1118959002024 putative Zn binding site [ion binding]; other site 1118959002025 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1118959002026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959002027 putative substrate translocation pore; other site 1118959002028 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1118959002029 putative deacylase active site [active] 1118959002030 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1118959002031 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1118959002032 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1118959002033 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1118959002034 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1118959002035 putative substrate binding site [chemical binding]; other site 1118959002036 putative ATP binding site [chemical binding]; other site 1118959002037 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1118959002038 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1118959002039 active site 1118959002040 phosphorylation site [posttranslational modification] 1118959002041 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1118959002042 active site 1118959002043 P-loop; other site 1118959002044 phosphorylation site [posttranslational modification] 1118959002045 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1118959002046 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1118959002047 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1118959002048 active site 1118959002049 dimer interface [polypeptide binding]; other site 1118959002050 Domain of unknown function DUF21; Region: DUF21; pfam01595 1118959002051 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1118959002052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1118959002053 Transporter associated domain; Region: CorC_HlyC; pfam03471 1118959002054 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1118959002055 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1118959002056 active site 1118959002057 catalytic tetrad [active] 1118959002058 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1118959002059 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1118959002060 Ligand binding site; other site 1118959002061 Putative Catalytic site; other site 1118959002062 DXD motif; other site 1118959002063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1118959002064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1118959002065 dimer interface [polypeptide binding]; other site 1118959002066 phosphorylation site [posttranslational modification] 1118959002067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959002068 ATP binding site [chemical binding]; other site 1118959002069 Mg2+ binding site [ion binding]; other site 1118959002070 G-X-G motif; other site 1118959002071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1118959002072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959002073 active site 1118959002074 phosphorylation site [posttranslational modification] 1118959002075 intermolecular recognition site; other site 1118959002076 dimerization interface [polypeptide binding]; other site 1118959002077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1118959002078 DNA binding site [nucleotide binding] 1118959002079 DoxX; Region: DoxX; pfam07681 1118959002080 Electron transfer DM13; Region: DM13; pfam10517 1118959002081 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1118959002082 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1118959002083 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1118959002084 active site 1118959002085 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1118959002086 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1118959002087 Ligand Binding Site [chemical binding]; other site 1118959002088 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1118959002089 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1118959002090 glutamine binding [chemical binding]; other site 1118959002091 catalytic triad [active] 1118959002092 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1118959002093 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1118959002094 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1118959002095 substrate-cofactor binding pocket; other site 1118959002096 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1118959002097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959002098 catalytic residue [active] 1118959002099 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1118959002100 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1118959002101 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1118959002102 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1118959002103 Sulfatase; Region: Sulfatase; pfam00884 1118959002104 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1118959002105 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1118959002106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1118959002107 ABC transporter; Region: ABC_tran_2; pfam12848 1118959002108 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1118959002109 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1118959002110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1118959002111 ATP binding site [chemical binding]; other site 1118959002112 putative Mg++ binding site [ion binding]; other site 1118959002113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1118959002114 nucleotide binding region [chemical binding]; other site 1118959002115 ATP-binding site [chemical binding]; other site 1118959002116 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1118959002117 HRDC domain; Region: HRDC; pfam00570 1118959002118 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1118959002119 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1118959002120 Walker A/P-loop; other site 1118959002121 ATP binding site [chemical binding]; other site 1118959002122 Q-loop/lid; other site 1118959002123 ABC transporter signature motif; other site 1118959002124 Walker B; other site 1118959002125 D-loop; other site 1118959002126 H-loop/switch region; other site 1118959002127 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1118959002128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959002129 dimer interface [polypeptide binding]; other site 1118959002130 conserved gate region; other site 1118959002131 ABC-ATPase subunit interface; other site 1118959002132 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1118959002133 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1118959002134 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1118959002135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1118959002136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959002137 homodimer interface [polypeptide binding]; other site 1118959002138 catalytic residue [active] 1118959002139 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1118959002140 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1118959002141 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1118959002142 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1118959002143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959002144 putative substrate translocation pore; other site 1118959002145 POT family; Region: PTR2; cl17359 1118959002146 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1118959002147 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1118959002148 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1118959002149 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1118959002150 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1118959002151 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1118959002152 active site 1118959002153 dimer interface [polypeptide binding]; other site 1118959002154 catalytic residues [active] 1118959002155 effector binding site; other site 1118959002156 R2 peptide binding site; other site 1118959002157 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1118959002158 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1118959002159 dimer interface [polypeptide binding]; other site 1118959002160 putative radical transfer pathway; other site 1118959002161 diiron center [ion binding]; other site 1118959002162 tyrosyl radical; other site 1118959002163 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959002164 ABC-ATPase subunit interface; other site 1118959002165 dimer interface [polypeptide binding]; other site 1118959002166 putative PBP binding regions; other site 1118959002167 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959002168 ABC-ATPase subunit interface; other site 1118959002169 dimer interface [polypeptide binding]; other site 1118959002170 putative PBP binding regions; other site 1118959002171 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1118959002172 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1118959002173 Walker A/P-loop; other site 1118959002174 ATP binding site [chemical binding]; other site 1118959002175 Q-loop/lid; other site 1118959002176 ABC transporter signature motif; other site 1118959002177 Walker B; other site 1118959002178 D-loop; other site 1118959002179 H-loop/switch region; other site 1118959002180 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1118959002181 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1118959002182 putative ligand binding residues [chemical binding]; other site 1118959002183 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1118959002184 FAD binding domain; Region: FAD_binding_4; pfam01565 1118959002185 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1118959002186 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1118959002187 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1118959002188 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1118959002189 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1118959002190 peptidase T; Region: peptidase-T; TIGR01882 1118959002191 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1118959002192 metal binding site [ion binding]; metal-binding site 1118959002193 dimer interface [polypeptide binding]; other site 1118959002194 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1118959002195 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1118959002196 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1118959002197 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1118959002198 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1118959002199 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1118959002200 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1118959002201 metal binding site [ion binding]; metal-binding site 1118959002202 active site 1118959002203 I-site; other site 1118959002204 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1118959002205 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1118959002206 Mg++ binding site [ion binding]; other site 1118959002207 putative catalytic motif [active] 1118959002208 substrate binding site [chemical binding]; other site 1118959002209 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1118959002210 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1118959002211 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1118959002212 EDD domain protein, DegV family; Region: DegV; TIGR00762 1118959002213 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1118959002214 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1118959002215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1118959002216 ATP binding site [chemical binding]; other site 1118959002217 putative Mg++ binding site [ion binding]; other site 1118959002218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1118959002219 nucleotide binding region [chemical binding]; other site 1118959002220 ATP-binding site [chemical binding]; other site 1118959002221 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1118959002222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1118959002223 active site 1118959002224 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1118959002225 30S subunit binding site; other site 1118959002226 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1118959002227 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1118959002228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1118959002229 nucleotide binding region [chemical binding]; other site 1118959002230 ATP-binding site [chemical binding]; other site 1118959002231 SEC-C motif; Region: SEC-C; pfam02810 1118959002232 peptide chain release factor 2; Provisional; Region: PRK06746 1118959002233 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1118959002234 RF-1 domain; Region: RF-1; pfam00472 1118959002235 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1118959002236 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1118959002237 Surface antigen [General function prediction only]; Region: COG3942 1118959002238 CHAP domain; Region: CHAP; pfam05257 1118959002239 HD domain; Region: HD_3; cl17350 1118959002240 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1118959002241 excinuclease ABC subunit B; Provisional; Region: PRK05298 1118959002242 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1118959002243 ATP binding site [chemical binding]; other site 1118959002244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1118959002245 nucleotide binding region [chemical binding]; other site 1118959002246 ATP-binding site [chemical binding]; other site 1118959002247 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1118959002248 UvrB/uvrC motif; Region: UVR; pfam02151 1118959002249 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1118959002250 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1118959002251 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1118959002252 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1118959002253 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1118959002254 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1118959002255 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1118959002256 Hpr binding site; other site 1118959002257 active site 1118959002258 homohexamer subunit interaction site [polypeptide binding]; other site 1118959002259 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1118959002260 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1118959002261 putative trimer interface [polypeptide binding]; other site 1118959002262 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1118959002263 putative CoA binding site [chemical binding]; other site 1118959002264 TPR repeat; Region: TPR_11; pfam13414 1118959002265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1118959002266 binding surface 1118959002267 TPR motif; other site 1118959002268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1118959002269 TPR motif; other site 1118959002270 binding surface 1118959002271 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1118959002272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1118959002273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959002274 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1118959002275 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1118959002276 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1118959002277 phosphate binding site [ion binding]; other site 1118959002278 dimer interface [polypeptide binding]; other site 1118959002279 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1118959002280 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 1118959002281 Clp protease; Region: CLP_protease; pfam00574 1118959002282 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1118959002283 oligomer interface [polypeptide binding]; other site 1118959002284 active site residues [active] 1118959002285 malate dehydrogenase; Provisional; Region: PRK13529 1118959002286 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1118959002287 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1118959002288 NAD(P) binding site [chemical binding]; other site 1118959002289 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1118959002290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1118959002291 NAD(P) binding site [chemical binding]; other site 1118959002292 active site 1118959002293 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1118959002294 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1118959002295 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1118959002296 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1118959002297 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1118959002298 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1118959002299 Phosphoglycerate kinase; Region: PGK; pfam00162 1118959002300 substrate binding site [chemical binding]; other site 1118959002301 hinge regions; other site 1118959002302 ADP binding site [chemical binding]; other site 1118959002303 catalytic site [active] 1118959002304 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1118959002305 triosephosphate isomerase; Provisional; Region: PRK14565 1118959002306 substrate binding site [chemical binding]; other site 1118959002307 dimer interface [polypeptide binding]; other site 1118959002308 catalytic triad [active] 1118959002309 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1118959002310 phosphoglyceromutase; Provisional; Region: PRK05434 1118959002311 enolase; Provisional; Region: eno; PRK00077 1118959002312 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1118959002313 dimer interface [polypeptide binding]; other site 1118959002314 metal binding site [ion binding]; metal-binding site 1118959002315 substrate binding pocket [chemical binding]; other site 1118959002316 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1118959002317 Esterase/lipase [General function prediction only]; Region: COG1647 1118959002318 ribonuclease R; Region: RNase_R; TIGR02063 1118959002319 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1118959002320 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1118959002321 RNB domain; Region: RNB; pfam00773 1118959002322 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1118959002323 RNA binding site [nucleotide binding]; other site 1118959002324 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1118959002325 SmpB-tmRNA interface; other site 1118959002326 Integral membrane protein DUF95; Region: DUF95; cl00572 1118959002327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959002328 Coenzyme A binding pocket [chemical binding]; other site 1118959002329 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1118959002330 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1118959002331 truncated secreted von Willebrandfactor-binding protein VWbp 1118959002332 Staphylococcal nuclease homologues; Region: SNc; smart00318 1118959002333 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1118959002334 Catalytic site; other site 1118959002335 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1118959002336 DNA-binding site [nucleotide binding]; DNA binding site 1118959002337 RNA-binding motif; other site 1118959002338 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1118959002339 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1118959002340 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1118959002341 catalytic core [active] 1118959002342 Lysine efflux permease [General function prediction only]; Region: COG1279 1118959002343 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1118959002344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1118959002345 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1118959002346 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1118959002347 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1118959002348 active site 1118959002349 catalytic residue [active] 1118959002350 dimer interface [polypeptide binding]; other site 1118959002351 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1118959002352 putative FMN binding site [chemical binding]; other site 1118959002353 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1118959002354 catalytic residues [active] 1118959002355 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1118959002356 ArsC family; Region: ArsC; pfam03960 1118959002357 putative ArsC-like catalytic residues; other site 1118959002358 putative TRX-like catalytic residues [active] 1118959002359 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1118959002360 lipoyl attachment site [posttranslational modification]; other site 1118959002361 truncated conserved hypothetical protein 1118959002362 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1118959002363 putative active site [active] 1118959002364 putative metal binding site [ion binding]; other site 1118959002365 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1118959002366 catalytic residues [active] 1118959002367 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1118959002368 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1118959002369 Walker A/P-loop; other site 1118959002370 ATP binding site [chemical binding]; other site 1118959002371 Q-loop/lid; other site 1118959002372 ABC transporter signature motif; other site 1118959002373 Walker B; other site 1118959002374 D-loop; other site 1118959002375 H-loop/switch region; other site 1118959002376 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1118959002377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959002378 dimer interface [polypeptide binding]; other site 1118959002379 conserved gate region; other site 1118959002380 ABC-ATPase subunit interface; other site 1118959002381 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1118959002382 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1118959002383 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1118959002384 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1118959002385 Int/Topo IB signature motif; other site 1118959002386 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1118959002387 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959002388 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1118959002389 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959002390 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1118959002391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959002392 non-specific DNA binding site [nucleotide binding]; other site 1118959002393 salt bridge; other site 1118959002394 sequence-specific DNA binding site [nucleotide binding]; other site 1118959002395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959002396 non-specific DNA binding site [nucleotide binding]; other site 1118959002397 salt bridge; other site 1118959002398 sequence-specific DNA binding site [nucleotide binding]; other site 1118959002399 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1118959002400 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 1118959002401 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1118959002402 Virulence-associated protein E; Region: VirE; pfam05272 1118959002403 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1118959002404 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1118959002405 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1118959002406 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959002407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1118959002408 Predicted membrane protein [Function unknown]; Region: COG2035 1118959002409 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1118959002410 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1118959002411 Walker A/P-loop; other site 1118959002412 ATP binding site [chemical binding]; other site 1118959002413 Q-loop/lid; other site 1118959002414 ABC transporter signature motif; other site 1118959002415 Walker B; other site 1118959002416 D-loop; other site 1118959002417 H-loop/switch region; other site 1118959002418 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1118959002419 FeS assembly protein SufD; Region: sufD; TIGR01981 1118959002420 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1118959002421 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1118959002422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1118959002423 catalytic residue [active] 1118959002424 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1118959002425 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1118959002426 trimerization site [polypeptide binding]; other site 1118959002427 active site 1118959002428 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1118959002429 FeS assembly protein SufB; Region: sufB; TIGR01980 1118959002430 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1118959002431 Domain of unknown function DUF21; Region: DUF21; pfam01595 1118959002432 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1118959002433 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1118959002434 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1118959002435 FMN binding site [chemical binding]; other site 1118959002436 substrate binding site [chemical binding]; other site 1118959002437 putative catalytic residue [active] 1118959002438 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1118959002439 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1118959002440 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1118959002441 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1118959002442 active site 1118959002443 metal binding site [ion binding]; metal-binding site 1118959002444 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1118959002445 lipoyl synthase; Provisional; Region: PRK05481 1118959002446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1118959002447 FeS/SAM binding site; other site 1118959002448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1118959002449 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1118959002450 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1118959002451 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1118959002452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959002453 active site 1118959002454 motif I; other site 1118959002455 motif II; other site 1118959002456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959002457 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1118959002458 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1118959002459 dimerization interface [polypeptide binding]; other site 1118959002460 ligand binding site [chemical binding]; other site 1118959002461 NADP binding site [chemical binding]; other site 1118959002462 catalytic site [active] 1118959002463 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1118959002464 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1118959002465 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1118959002466 acyl-activating enzyme (AAE) consensus motif; other site 1118959002467 AMP binding site [chemical binding]; other site 1118959002468 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1118959002469 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1118959002470 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1118959002471 DltD N-terminal region; Region: DltD_N; pfam04915 1118959002472 DltD central region; Region: DltD_M; pfam04918 1118959002473 DltD C-terminal region; Region: DltD_C; pfam04914 1118959002474 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1118959002475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1118959002476 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1118959002477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959002478 hypothetical protein; Provisional; Region: PRK13669 1118959002479 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1118959002480 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1118959002481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959002482 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1118959002483 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1118959002484 interface (dimer of trimers) [polypeptide binding]; other site 1118959002485 Substrate-binding/catalytic site; other site 1118959002486 Zn-binding sites [ion binding]; other site 1118959002487 Predicted permease [General function prediction only]; Region: COG2056 1118959002488 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1118959002489 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1118959002490 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1118959002491 CoenzymeA binding site [chemical binding]; other site 1118959002492 subunit interaction site [polypeptide binding]; other site 1118959002493 PHB binding site; other site 1118959002494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1118959002495 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1118959002496 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1118959002497 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1118959002498 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1118959002499 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1118959002500 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1118959002501 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1118959002502 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1118959002503 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1118959002504 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1118959002505 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1118959002506 Kinase associated protein B; Region: KapB; pfam08810 1118959002507 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1118959002508 active site 1118959002509 general stress protein 13; Validated; Region: PRK08059 1118959002510 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1118959002511 RNA binding site [nucleotide binding]; other site 1118959002512 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1118959002513 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1118959002514 putative active site [active] 1118959002515 putative FMN binding site [chemical binding]; other site 1118959002516 putative substrate binding site [chemical binding]; other site 1118959002517 putative catalytic residue [active] 1118959002518 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1118959002519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1118959002520 inhibitor-cofactor binding pocket; inhibition site 1118959002521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959002522 catalytic residue [active] 1118959002523 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1118959002524 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1118959002525 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1118959002526 NAD(P) binding site [chemical binding]; other site 1118959002527 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1118959002528 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1118959002529 active site 1118959002530 catalytic site [active] 1118959002531 metal binding site [ion binding]; metal-binding site 1118959002532 argininosuccinate lyase; Provisional; Region: PRK00855 1118959002533 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1118959002534 active sites [active] 1118959002535 tetramer interface [polypeptide binding]; other site 1118959002536 argininosuccinate synthase; Provisional; Region: PRK13820 1118959002537 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1118959002538 ANP binding site [chemical binding]; other site 1118959002539 Substrate Binding Site II [chemical binding]; other site 1118959002540 Substrate Binding Site I [chemical binding]; other site 1118959002541 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1118959002542 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1118959002543 active site 1118959002544 dimer interface [polypeptide binding]; other site 1118959002545 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1118959002546 dimer interface [polypeptide binding]; other site 1118959002547 active site 1118959002548 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1118959002549 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1118959002550 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1118959002551 Catalytic site [active] 1118959002552 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1118959002553 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1118959002554 Catalytic site [active] 1118959002555 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1118959002556 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1118959002557 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1118959002558 Part of AAA domain; Region: AAA_19; pfam13245 1118959002559 Family description; Region: UvrD_C_2; pfam13538 1118959002560 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1118959002561 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1118959002562 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1118959002563 hypothetical protein; Provisional; Region: PRK13673 1118959002564 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1118959002565 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1118959002566 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959002567 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1118959002568 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1118959002569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959002570 active site 1118959002571 motif I; other site 1118959002572 motif II; other site 1118959002573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959002574 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1118959002575 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1118959002576 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1118959002577 catalytic triad [active] 1118959002578 catalytic triad [active] 1118959002579 oxyanion hole [active] 1118959002580 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1118959002581 Clp amino terminal domain; Region: Clp_N; pfam02861 1118959002582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959002583 Walker A motif; other site 1118959002584 ATP binding site [chemical binding]; other site 1118959002585 Walker B motif; other site 1118959002586 arginine finger; other site 1118959002587 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1118959002588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959002589 Walker A motif; other site 1118959002590 ATP binding site [chemical binding]; other site 1118959002591 Walker B motif; other site 1118959002592 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1118959002593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1118959002594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1118959002595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1118959002596 dimerization interface [polypeptide binding]; other site 1118959002597 potential frameshift: common BLAST hit: gi|150393463|ref|YP_001316138.1| 2-isopropylmalate synthase 1118959002598 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1118959002599 catalytic residues [active] 1118959002600 potential frameshift: common BLAST hit: gi|150393463|ref|YP_001316138.1| 2-isopropylmalate synthase 1118959002601 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1118959002602 metal binding site [ion binding]; metal-binding site 1118959002603 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1118959002604 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1118959002605 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1118959002606 substrate binding site [chemical binding]; other site 1118959002607 MAP domain; Region: MAP; pfam03642 1118959002608 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1118959002609 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1118959002610 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1118959002611 dimer interface [polypeptide binding]; other site 1118959002612 active site 1118959002613 CoA binding pocket [chemical binding]; other site 1118959002614 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1118959002615 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1118959002616 dimer interface [polypeptide binding]; other site 1118959002617 active site 1118959002618 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1118959002619 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1118959002620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959002621 dimer interface [polypeptide binding]; other site 1118959002622 conserved gate region; other site 1118959002623 putative PBP binding loops; other site 1118959002624 ABC-ATPase subunit interface; other site 1118959002625 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1118959002626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959002627 dimer interface [polypeptide binding]; other site 1118959002628 conserved gate region; other site 1118959002629 putative PBP binding loops; other site 1118959002630 ABC-ATPase subunit interface; other site 1118959002631 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1118959002632 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1118959002633 Walker A/P-loop; other site 1118959002634 ATP binding site [chemical binding]; other site 1118959002635 Q-loop/lid; other site 1118959002636 ABC transporter signature motif; other site 1118959002637 Walker B; other site 1118959002638 D-loop; other site 1118959002639 H-loop/switch region; other site 1118959002640 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1118959002641 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1118959002642 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1118959002643 Walker A/P-loop; other site 1118959002644 ATP binding site [chemical binding]; other site 1118959002645 Q-loop/lid; other site 1118959002646 ABC transporter signature motif; other site 1118959002647 Walker B; other site 1118959002648 D-loop; other site 1118959002649 H-loop/switch region; other site 1118959002650 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1118959002651 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1118959002652 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1118959002653 peptide binding site [polypeptide binding]; other site 1118959002654 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1118959002655 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1118959002656 peptide binding site [polypeptide binding]; other site 1118959002657 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1118959002658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1118959002659 Walker A/P-loop; other site 1118959002660 ATP binding site [chemical binding]; other site 1118959002661 Q-loop/lid; other site 1118959002662 ABC transporter signature motif; other site 1118959002663 Walker B; other site 1118959002664 D-loop; other site 1118959002665 H-loop/switch region; other site 1118959002666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1118959002667 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1118959002668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1118959002669 Walker A/P-loop; other site 1118959002670 ATP binding site [chemical binding]; other site 1118959002671 Q-loop/lid; other site 1118959002672 ABC transporter signature motif; other site 1118959002673 Walker B; other site 1118959002674 D-loop; other site 1118959002675 H-loop/switch region; other site 1118959002676 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1118959002677 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1118959002678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959002679 dimer interface [polypeptide binding]; other site 1118959002680 conserved gate region; other site 1118959002681 putative PBP binding loops; other site 1118959002682 ABC-ATPase subunit interface; other site 1118959002683 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1118959002684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959002685 dimer interface [polypeptide binding]; other site 1118959002686 conserved gate region; other site 1118959002687 putative PBP binding loops; other site 1118959002688 ABC-ATPase subunit interface; other site 1118959002689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1118959002690 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959002691 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1118959002692 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959002693 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1118959002694 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1118959002695 active site 1118959002696 HIGH motif; other site 1118959002697 dimer interface [polypeptide binding]; other site 1118959002698 KMSKS motif; other site 1118959002699 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1118959002700 ArsC family; Region: ArsC; pfam03960 1118959002701 putative catalytic residues [active] 1118959002702 thiol/disulfide switch; other site 1118959002703 adaptor protein; Provisional; Region: PRK02315 1118959002704 Competence protein CoiA-like family; Region: CoiA; cl11541 1118959002705 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1118959002706 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1118959002707 active site 1118959002708 Zn binding site [ion binding]; other site 1118959002709 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1118959002710 Thioredoxin; Region: Thioredoxin_5; pfam13743 1118959002711 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1118959002712 apolar tunnel; other site 1118959002713 heme binding site [chemical binding]; other site 1118959002714 dimerization interface [polypeptide binding]; other site 1118959002715 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1118959002716 putative active site [active] 1118959002717 putative metal binding residues [ion binding]; other site 1118959002718 signature motif; other site 1118959002719 putative triphosphate binding site [ion binding]; other site 1118959002720 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1118959002721 synthetase active site [active] 1118959002722 NTP binding site [chemical binding]; other site 1118959002723 metal binding site [ion binding]; metal-binding site 1118959002724 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1118959002725 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1118959002726 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1118959002727 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1118959002728 active site 1118959002729 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1118959002730 MgtE intracellular N domain; Region: MgtE_N; smart00924 1118959002731 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1118959002732 Divalent cation transporter; Region: MgtE; pfam01769 1118959002733 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1118959002734 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1118959002735 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1118959002736 TrkA-N domain; Region: TrkA_N; pfam02254 1118959002737 TrkA-C domain; Region: TrkA_C; pfam02080 1118959002738 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1118959002739 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1118959002740 NAD binding site [chemical binding]; other site 1118959002741 homotetramer interface [polypeptide binding]; other site 1118959002742 homodimer interface [polypeptide binding]; other site 1118959002743 substrate binding site [chemical binding]; other site 1118959002744 active site 1118959002745 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1118959002746 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1118959002747 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1118959002748 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1118959002749 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1118959002750 Putative esterase; Region: Esterase; pfam00756 1118959002751 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1118959002752 minor groove reading motif; other site 1118959002753 helix-hairpin-helix signature motif; other site 1118959002754 substrate binding pocket [chemical binding]; other site 1118959002755 active site 1118959002756 hypothetical protein; Provisional; Region: PRK13679 1118959002757 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1118959002758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959002759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1118959002760 putative substrate translocation pore; other site 1118959002761 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1118959002762 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1118959002763 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1118959002764 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1118959002765 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1118959002766 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1118959002767 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1118959002768 YueH-like protein; Region: YueH; pfam14166 1118959002769 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1118959002770 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1118959002771 G1 box; other site 1118959002772 putative GEF interaction site [polypeptide binding]; other site 1118959002773 GTP/Mg2+ binding site [chemical binding]; other site 1118959002774 Switch I region; other site 1118959002775 G2 box; other site 1118959002776 G3 box; other site 1118959002777 Switch II region; other site 1118959002778 G4 box; other site 1118959002779 G5 box; other site 1118959002780 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1118959002781 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1118959002782 potential frameshift: common BLAST hit: gi|49485861|ref|YP_043082.1| protease 1118959002783 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1118959002784 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1118959002785 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1118959002786 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1118959002787 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1118959002788 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1118959002789 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1118959002790 active site 1118959002791 metal binding site [ion binding]; metal-binding site 1118959002792 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1118959002793 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1118959002794 IDEAL domain; Region: IDEAL; pfam08858 1118959002795 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1118959002796 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1118959002797 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1118959002798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1118959002799 CAAX protease self-immunity; Region: Abi; pfam02517 1118959002800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1118959002801 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959002802 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1118959002803 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959002804 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1118959002805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1118959002806 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1118959002807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1118959002808 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1118959002809 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1118959002810 Walker A/P-loop; other site 1118959002811 ATP binding site [chemical binding]; other site 1118959002812 Q-loop/lid; other site 1118959002813 ABC transporter signature motif; other site 1118959002814 Walker B; other site 1118959002815 D-loop; other site 1118959002816 H-loop/switch region; other site 1118959002817 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1118959002818 Predicted membrane protein [Function unknown]; Region: COG2259 1118959002819 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1118959002820 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1118959002821 siderophore binding site; other site 1118959002822 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1118959002823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959002824 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1118959002825 Coenzyme A binding pocket [chemical binding]; other site 1118959002826 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1118959002827 UbiA prenyltransferase family; Region: UbiA; pfam01040 1118959002828 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1118959002829 isochorismate synthases; Region: isochor_syn; TIGR00543 1118959002830 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1118959002831 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1118959002832 dimer interface [polypeptide binding]; other site 1118959002833 tetramer interface [polypeptide binding]; other site 1118959002834 PYR/PP interface [polypeptide binding]; other site 1118959002835 TPP binding site [chemical binding]; other site 1118959002836 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1118959002837 TPP-binding site; other site 1118959002838 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1118959002839 PGAP1-like protein; Region: PGAP1; pfam07819 1118959002840 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1118959002841 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1118959002842 substrate binding site [chemical binding]; other site 1118959002843 oxyanion hole (OAH) forming residues; other site 1118959002844 trimer interface [polypeptide binding]; other site 1118959002845 Staphostatin B; Region: Staphostatin_B; pfam09023 1118959002846 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1118959002847 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1118959002848 aminotransferase A; Validated; Region: PRK07683 1118959002849 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1118959002850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959002851 homodimer interface [polypeptide binding]; other site 1118959002852 catalytic residue [active] 1118959002853 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1118959002854 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1118959002855 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1118959002856 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1118959002857 MarR family; Region: MarR; pfam01047 1118959002858 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1118959002859 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1118959002860 amidase catalytic site [active] 1118959002861 Zn binding residues [ion binding]; other site 1118959002862 substrate binding site [chemical binding]; other site 1118959002863 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1118959002864 Lysozyme subfamily 2; Region: LYZ2; smart00047 1118959002865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959002866 Coenzyme A binding pocket [chemical binding]; other site 1118959002867 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1118959002868 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1118959002869 Beta-lactamase; Region: Beta-lactamase; pfam00144 1118959002870 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1118959002871 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1118959002872 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1118959002873 Subunit I/III interface [polypeptide binding]; other site 1118959002874 Subunit III/IV interface [polypeptide binding]; other site 1118959002875 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1118959002876 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1118959002877 D-pathway; other site 1118959002878 Putative ubiquinol binding site [chemical binding]; other site 1118959002879 Low-spin heme (heme b) binding site [chemical binding]; other site 1118959002880 Putative water exit pathway; other site 1118959002881 Binuclear center (heme o3/CuB) [ion binding]; other site 1118959002882 K-pathway; other site 1118959002883 Putative proton exit pathway; other site 1118959002884 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1118959002885 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1118959002886 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1118959002887 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1118959002888 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1118959002889 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1118959002890 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1118959002891 homodimer interface [polypeptide binding]; other site 1118959002892 NADP binding site [chemical binding]; other site 1118959002893 substrate binding site [chemical binding]; other site 1118959002894 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1118959002895 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1118959002896 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1118959002897 NAD binding site [chemical binding]; other site 1118959002898 ATP-grasp domain; Region: ATP-grasp; pfam02222 1118959002899 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1118959002900 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1118959002901 ATP binding site [chemical binding]; other site 1118959002902 active site 1118959002903 substrate binding site [chemical binding]; other site 1118959002904 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1118959002905 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1118959002906 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1118959002907 putative active site [active] 1118959002908 catalytic triad [active] 1118959002909 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1118959002910 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1118959002911 dimerization interface [polypeptide binding]; other site 1118959002912 ATP binding site [chemical binding]; other site 1118959002913 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1118959002914 dimerization interface [polypeptide binding]; other site 1118959002915 ATP binding site [chemical binding]; other site 1118959002916 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1118959002917 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1118959002918 active site 1118959002919 tetramer interface [polypeptide binding]; other site 1118959002920 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1118959002921 active site 1118959002922 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1118959002923 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1118959002924 dimerization interface [polypeptide binding]; other site 1118959002925 putative ATP binding site [chemical binding]; other site 1118959002926 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1118959002927 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1118959002928 active site 1118959002929 substrate binding site [chemical binding]; other site 1118959002930 cosubstrate binding site; other site 1118959002931 catalytic site [active] 1118959002932 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1118959002933 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1118959002934 purine monophosphate binding site [chemical binding]; other site 1118959002935 dimer interface [polypeptide binding]; other site 1118959002936 putative catalytic residues [active] 1118959002937 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1118959002938 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1118959002939 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1118959002940 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1118959002941 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1118959002942 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1118959002943 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1118959002944 potential frameshift: common BLAST hit: gi|49485915|ref|YP_043136.1| ABC transporter ATP-binding protein 1118959002945 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1118959002946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959002947 Q-loop/lid; other site 1118959002948 ABC transporter signature motif; other site 1118959002949 Walker B; other site 1118959002950 D-loop; other site 1118959002951 H-loop/switch region; other site 1118959002952 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1118959002953 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1118959002954 Walker A/P-loop; other site 1118959002955 ATP binding site [chemical binding]; other site 1118959002956 Q-loop/lid; other site 1118959002957 ABC transporter signature motif; other site 1118959002958 Walker B; other site 1118959002959 D-loop; other site 1118959002960 H-loop/switch region; other site 1118959002961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959002962 Walker A/P-loop; other site 1118959002963 ATP binding site [chemical binding]; other site 1118959002964 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1118959002965 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1118959002966 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1118959002967 putative RNA binding site [nucleotide binding]; other site 1118959002968 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1118959002969 Domain of unknown function (DUF697); Region: DUF697; cl12064 1118959002970 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1118959002971 dimerization domain swap beta strand [polypeptide binding]; other site 1118959002972 regulatory protein interface [polypeptide binding]; other site 1118959002973 active site 1118959002974 regulatory phosphorylation site [posttranslational modification]; other site 1118959002975 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1118959002976 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1118959002977 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1118959002978 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1118959002979 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1118959002980 catalytic residues [active] 1118959002981 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1118959002982 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1118959002983 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1118959002984 TrkA-N domain; Region: TrkA_N; pfam02254 1118959002985 TrkA-C domain; Region: TrkA_C; pfam02080 1118959002986 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1118959002987 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1118959002988 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1118959002989 hypothetical protein; Provisional; Region: PRK13667 1118959002990 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1118959002991 active site 1118959002992 catalytic residues [active] 1118959002993 metal binding site [ion binding]; metal-binding site 1118959002994 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1118959002995 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1118959002996 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1118959002997 TPP-binding site [chemical binding]; other site 1118959002998 tetramer interface [polypeptide binding]; other site 1118959002999 heterodimer interface [polypeptide binding]; other site 1118959003000 phosphorylation loop region [posttranslational modification] 1118959003001 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1118959003002 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1118959003003 alpha subunit interface [polypeptide binding]; other site 1118959003004 TPP binding site [chemical binding]; other site 1118959003005 heterodimer interface [polypeptide binding]; other site 1118959003006 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1118959003007 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1118959003008 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1118959003009 E3 interaction surface; other site 1118959003010 lipoyl attachment site [posttranslational modification]; other site 1118959003011 e3 binding domain; Region: E3_binding; pfam02817 1118959003012 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1118959003013 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1118959003014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1118959003015 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959003016 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1118959003017 hypothetical protein; Provisional; Region: PRK04387 1118959003018 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1118959003019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959003020 non-specific DNA binding site [nucleotide binding]; other site 1118959003021 salt bridge; other site 1118959003022 sequence-specific DNA binding site [nucleotide binding]; other site 1118959003023 Cupin domain; Region: Cupin_2; pfam07883 1118959003024 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1118959003025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959003026 Walker A/P-loop; other site 1118959003027 ATP binding site [chemical binding]; other site 1118959003028 Q-loop/lid; other site 1118959003029 ABC transporter signature motif; other site 1118959003030 Walker B; other site 1118959003031 D-loop; other site 1118959003032 H-loop/switch region; other site 1118959003033 TOBE domain; Region: TOBE_2; pfam08402 1118959003034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959003035 putative PBP binding loops; other site 1118959003036 dimer interface [polypeptide binding]; other site 1118959003037 ABC-ATPase subunit interface; other site 1118959003038 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1118959003039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959003040 dimer interface [polypeptide binding]; other site 1118959003041 conserved gate region; other site 1118959003042 putative PBP binding loops; other site 1118959003043 ABC-ATPase subunit interface; other site 1118959003044 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1118959003045 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 1118959003046 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1118959003047 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1118959003048 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1118959003049 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1118959003050 manganese transport protein MntH; Reviewed; Region: PRK00701 1118959003051 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1118959003052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1118959003053 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1118959003054 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1118959003055 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1118959003056 active site 1118959003057 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1118959003058 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1118959003059 G1 box; other site 1118959003060 putative GEF interaction site [polypeptide binding]; other site 1118959003061 GTP/Mg2+ binding site [chemical binding]; other site 1118959003062 Switch I region; other site 1118959003063 G2 box; other site 1118959003064 G3 box; other site 1118959003065 Switch II region; other site 1118959003066 G4 box; other site 1118959003067 G5 box; other site 1118959003068 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1118959003069 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1118959003070 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1118959003071 hypothetical protein; Provisional; Region: PRK13666 1118959003072 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1118959003073 pyruvate carboxylase; Reviewed; Region: PRK12999 1118959003074 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1118959003075 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1118959003076 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1118959003077 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1118959003078 active site 1118959003079 catalytic residues [active] 1118959003080 metal binding site [ion binding]; metal-binding site 1118959003081 homodimer binding site [polypeptide binding]; other site 1118959003082 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1118959003083 carboxyltransferase (CT) interaction site; other site 1118959003084 biotinylation site [posttranslational modification]; other site 1118959003085 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1118959003086 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1118959003087 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1118959003088 UbiA prenyltransferase family; Region: UbiA; pfam01040 1118959003089 Predicted membrane protein [Function unknown]; Region: COG2322 1118959003090 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1118959003091 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1118959003092 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1118959003093 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1118959003094 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1118959003095 putative active site [active] 1118959003096 catalytic site [active] 1118959003097 putative metal binding site [ion binding]; other site 1118959003098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 1118959003099 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1118959003100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959003101 S-adenosylmethionine binding site [chemical binding]; other site 1118959003102 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1118959003103 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1118959003104 active site 1118959003105 (T/H)XGH motif; other site 1118959003106 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1118959003107 hypothetical protein; Provisional; Region: PRK13670 1118959003108 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1118959003109 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1118959003110 heme uptake protein IsdB; Region: IsdB; TIGR03657 1118959003111 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1118959003112 NEAr Transporter domain; Region: NEAT; smart00725 1118959003113 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1118959003114 heme-binding site [chemical binding]; other site 1118959003115 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1118959003116 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1118959003117 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1118959003118 heme-binding site [chemical binding]; other site 1118959003119 heme uptake protein IsdC; Region: IsdC; TIGR03656 1118959003120 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1118959003121 heme-binding site [chemical binding]; other site 1118959003122 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 1118959003123 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1118959003124 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1118959003125 intersubunit interface [polypeptide binding]; other site 1118959003126 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1118959003127 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959003128 ABC-ATPase subunit interface; other site 1118959003129 dimer interface [polypeptide binding]; other site 1118959003130 putative PBP binding regions; other site 1118959003131 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1118959003132 active site 1118959003133 catalytic site [active] 1118959003134 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 1118959003135 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1118959003136 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1118959003137 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1118959003138 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1118959003139 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1118959003140 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1118959003141 dimer interface [polypeptide binding]; other site 1118959003142 motif 1; other site 1118959003143 active site 1118959003144 motif 2; other site 1118959003145 motif 3; other site 1118959003146 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1118959003147 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1118959003148 putative tRNA-binding site [nucleotide binding]; other site 1118959003149 B3/4 domain; Region: B3_4; pfam03483 1118959003150 tRNA synthetase B5 domain; Region: B5; smart00874 1118959003151 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1118959003152 dimer interface [polypeptide binding]; other site 1118959003153 motif 1; other site 1118959003154 motif 3; other site 1118959003155 motif 2; other site 1118959003156 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1118959003157 ribonuclease HIII; Provisional; Region: PRK00996 1118959003158 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1118959003159 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1118959003160 RNA/DNA hybrid binding site [nucleotide binding]; other site 1118959003161 active site 1118959003162 Cell division protein ZapA; Region: ZapA; cl01146 1118959003163 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1118959003164 Colicin V production protein; Region: Colicin_V; pfam02674 1118959003165 hypothetical protein; Provisional; Region: PRK08609 1118959003166 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1118959003167 active site 1118959003168 primer binding site [nucleotide binding]; other site 1118959003169 NTP binding site [chemical binding]; other site 1118959003170 metal binding triad [ion binding]; metal-binding site 1118959003171 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1118959003172 active site 1118959003173 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1118959003174 MutS domain III; Region: MutS_III; pfam05192 1118959003175 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1118959003176 Walker A/P-loop; other site 1118959003177 ATP binding site [chemical binding]; other site 1118959003178 Q-loop/lid; other site 1118959003179 ABC transporter signature motif; other site 1118959003180 Walker B; other site 1118959003181 D-loop; other site 1118959003182 H-loop/switch region; other site 1118959003183 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1118959003184 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1118959003185 catalytic residues [active] 1118959003186 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1118959003187 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1118959003188 GIY-YIG motif/motif A; other site 1118959003189 active site 1118959003190 catalytic site [active] 1118959003191 putative DNA binding site [nucleotide binding]; other site 1118959003192 metal binding site [ion binding]; metal-binding site 1118959003193 UvrB/uvrC motif; Region: UVR; pfam02151 1118959003194 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1118959003195 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1118959003196 putative Iron-sulfur protein interface [polypeptide binding]; other site 1118959003197 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1118959003198 proximal heme binding site [chemical binding]; other site 1118959003199 distal heme binding site [chemical binding]; other site 1118959003200 putative dimer interface [polypeptide binding]; other site 1118959003201 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1118959003202 L-aspartate oxidase; Provisional; Region: PRK06175 1118959003203 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1118959003204 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1118959003205 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1118959003206 glutamate racemase; Provisional; Region: PRK00865 1118959003207 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1118959003208 active site 1118959003209 dimerization interface [polypeptide binding]; other site 1118959003210 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1118959003211 active site 1118959003212 metal binding site [ion binding]; metal-binding site 1118959003213 homotetramer interface [polypeptide binding]; other site 1118959003214 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1118959003215 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 1118959003216 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1118959003217 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1118959003218 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1118959003219 superantigen-like protein; Reviewed; Region: PRK13350 1118959003220 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959003221 superantigen-like protein; Reviewed; Region: PRK13349 1118959003222 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959003223 superantigen-like protein; Reviewed; Region: PRK13043 1118959003224 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959003225 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1118959003226 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1118959003227 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1118959003228 carbamate kinase; Reviewed; Region: PRK12686 1118959003229 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1118959003230 putative substrate binding site [chemical binding]; other site 1118959003231 nucleotide binding site [chemical binding]; other site 1118959003232 nucleotide binding site [chemical binding]; other site 1118959003233 homodimer interface [polypeptide binding]; other site 1118959003234 Predicted membrane protein [Function unknown]; Region: COG1288 1118959003235 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1118959003236 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1118959003237 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1118959003238 gating phenylalanine in ion channel; other site 1118959003239 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1118959003240 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1118959003241 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1118959003242 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959003243 motif II; other site 1118959003244 hypothetical protein; Provisional; Region: PRK13688 1118959003245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1118959003246 Coenzyme A binding pocket [chemical binding]; other site 1118959003247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1118959003248 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1118959003249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1118959003250 MraZ protein; Region: MraZ; pfam02381 1118959003251 MraZ protein; Region: MraZ; pfam02381 1118959003252 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1118959003253 MraW methylase family; Region: Methyltransf_5; pfam01795 1118959003254 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1118959003255 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1118959003256 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1118959003257 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1118959003258 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1118959003259 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1118959003260 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1118959003261 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1118959003262 Mg++ binding site [ion binding]; other site 1118959003263 putative catalytic motif [active] 1118959003264 putative substrate binding site [chemical binding]; other site 1118959003265 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1118959003266 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1118959003267 NAD binding site [chemical binding]; other site 1118959003268 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1118959003269 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1118959003270 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1118959003271 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1118959003272 Cell division protein FtsQ; Region: FtsQ; pfam03799 1118959003273 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1118959003274 Cell division protein FtsA; Region: FtsA; smart00842 1118959003275 Cell division protein FtsA; Region: FtsA; pfam14450 1118959003276 cell division protein FtsZ; Validated; Region: PRK09330 1118959003277 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1118959003278 nucleotide binding site [chemical binding]; other site 1118959003279 SulA interaction site; other site 1118959003280 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1118959003281 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1118959003282 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1118959003283 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1118959003284 catalytic residue [active] 1118959003285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1118959003286 YGGT family; Region: YGGT; pfam02325 1118959003287 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1118959003288 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1118959003289 RNA binding surface [nucleotide binding]; other site 1118959003290 DivIVA protein; Region: DivIVA; pfam05103 1118959003291 DivIVA domain; Region: DivI1A_domain; TIGR03544 1118959003292 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1118959003293 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1118959003294 HIGH motif; other site 1118959003295 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1118959003296 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1118959003297 active site 1118959003298 KMSKS motif; other site 1118959003299 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1118959003300 tRNA binding surface [nucleotide binding]; other site 1118959003301 anticodon binding site; other site 1118959003302 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1118959003303 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1118959003304 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1118959003305 active site 1118959003306 truncated transposase 1118959003307 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1118959003308 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1118959003309 lipoprotein signal peptidase; Provisional; Region: PRK14787 1118959003310 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1118959003311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1118959003312 RNA binding surface [nucleotide binding]; other site 1118959003313 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1118959003314 active site 1118959003315 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1118959003316 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1118959003317 uracil transporter; Provisional; Region: PRK10720 1118959003318 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1118959003319 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1118959003320 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1118959003321 dihydroorotase; Validated; Region: pyrC; PRK09357 1118959003322 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1118959003323 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1118959003324 active site 1118959003325 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1118959003326 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1118959003327 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1118959003328 catalytic site [active] 1118959003329 subunit interface [polypeptide binding]; other site 1118959003330 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1118959003331 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1118959003332 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1118959003333 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1118959003334 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1118959003335 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1118959003336 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1118959003337 IMP binding site; other site 1118959003338 dimer interface [polypeptide binding]; other site 1118959003339 interdomain contacts; other site 1118959003340 partial ornithine binding site; other site 1118959003341 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1118959003342 active site 1118959003343 dimer interface [polypeptide binding]; other site 1118959003344 potential frameshift: common BLAST hit: gi|269202819|ref|YP_003282088.1| orotate phosphoribosyltransferase 1118959003345 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1118959003346 active site 1118959003347 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1118959003348 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1118959003349 dimer interface [polypeptide binding]; other site 1118959003350 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1118959003351 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1118959003352 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1118959003353 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1118959003354 catalytic site [active] 1118959003355 G-X2-G-X-G-K; other site 1118959003356 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1118959003357 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1118959003358 Flavoprotein; Region: Flavoprotein; pfam02441 1118959003359 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1118959003360 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1118959003361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1118959003362 ATP binding site [chemical binding]; other site 1118959003363 putative Mg++ binding site [ion binding]; other site 1118959003364 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1118959003365 nucleotide binding region [chemical binding]; other site 1118959003366 ATP-binding site [chemical binding]; other site 1118959003367 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1118959003368 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1118959003369 active site 1118959003370 catalytic residues [active] 1118959003371 metal binding site [ion binding]; metal-binding site 1118959003372 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1118959003373 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1118959003374 putative active site [active] 1118959003375 substrate binding site [chemical binding]; other site 1118959003376 putative cosubstrate binding site; other site 1118959003377 catalytic site [active] 1118959003378 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1118959003379 substrate binding site [chemical binding]; other site 1118959003380 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1118959003381 NusB family; Region: NusB; pfam01029 1118959003382 putative RNA binding site [nucleotide binding]; other site 1118959003383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959003384 S-adenosylmethionine binding site [chemical binding]; other site 1118959003385 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1118959003386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1118959003387 FeS/SAM binding site; other site 1118959003388 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1118959003389 Protein phosphatase 2C; Region: PP2C; pfam00481 1118959003390 active site 1118959003391 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1118959003392 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1118959003393 active site 1118959003394 ATP binding site [chemical binding]; other site 1118959003395 substrate binding site [chemical binding]; other site 1118959003396 activation loop (A-loop); other site 1118959003397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1118959003398 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1118959003399 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1118959003400 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1118959003401 Predicted GTPases [General function prediction only]; Region: COG1162 1118959003402 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1118959003403 RNA binding site [nucleotide binding]; other site 1118959003404 homodimer interface [polypeptide binding]; other site 1118959003405 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1118959003406 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1118959003407 GTP/Mg2+ binding site [chemical binding]; other site 1118959003408 G4 box; other site 1118959003409 G5 box; other site 1118959003410 G1 box; other site 1118959003411 Switch I region; other site 1118959003412 G2 box; other site 1118959003413 G3 box; other site 1118959003414 Switch II region; other site 1118959003415 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1118959003416 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1118959003417 substrate binding site [chemical binding]; other site 1118959003418 hexamer interface [polypeptide binding]; other site 1118959003419 metal binding site [ion binding]; metal-binding site 1118959003420 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1118959003421 Thiamine pyrophosphokinase; Region: TPK; cd07995 1118959003422 active site 1118959003423 dimerization interface [polypeptide binding]; other site 1118959003424 thiamine binding site [chemical binding]; other site 1118959003425 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1118959003426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1118959003427 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1118959003428 DAK2 domain; Region: Dak2; pfam02734 1118959003429 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1118959003430 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1118959003431 generic binding surface II; other site 1118959003432 ssDNA binding site; other site 1118959003433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1118959003434 ATP binding site [chemical binding]; other site 1118959003435 putative Mg++ binding site [ion binding]; other site 1118959003436 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1118959003437 nucleotide binding region [chemical binding]; other site 1118959003438 ATP-binding site [chemical binding]; other site 1118959003439 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1118959003440 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1118959003441 active site 2 [active] 1118959003442 active site 1 [active] 1118959003443 putative phosphate acyltransferase; Provisional; Region: PRK05331 1118959003444 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1118959003445 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1118959003446 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1118959003447 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1118959003448 NAD(P) binding site [chemical binding]; other site 1118959003449 homotetramer interface [polypeptide binding]; other site 1118959003450 homodimer interface [polypeptide binding]; other site 1118959003451 active site 1118959003452 acyl carrier protein; Provisional; Region: acpP; PRK00982 1118959003453 ribonuclease III; Reviewed; Region: rnc; PRK00102 1118959003454 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1118959003455 dimerization interface [polypeptide binding]; other site 1118959003456 active site 1118959003457 metal binding site [ion binding]; metal-binding site 1118959003458 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1118959003459 dsRNA binding site [nucleotide binding]; other site 1118959003460 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1118959003461 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1118959003462 Walker A/P-loop; other site 1118959003463 ATP binding site [chemical binding]; other site 1118959003464 Q-loop/lid; other site 1118959003465 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1118959003466 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1118959003467 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1118959003468 ABC transporter signature motif; other site 1118959003469 Walker B; other site 1118959003470 D-loop; other site 1118959003471 H-loop/switch region; other site 1118959003472 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1118959003473 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1118959003474 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1118959003475 P loop; other site 1118959003476 GTP binding site [chemical binding]; other site 1118959003477 putative DNA-binding protein; Validated; Region: PRK00118 1118959003478 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1118959003479 signal recognition particle protein; Provisional; Region: PRK10867 1118959003480 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1118959003481 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1118959003482 P loop; other site 1118959003483 GTP binding site [chemical binding]; other site 1118959003484 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1118959003485 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1118959003486 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1118959003487 RimM N-terminal domain; Region: RimM; pfam01782 1118959003488 PRC-barrel domain; Region: PRC; pfam05239 1118959003489 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1118959003490 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1118959003491 Predicted membrane protein [Function unknown]; Region: COG4485 1118959003492 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1118959003493 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1118959003494 GTP/Mg2+ binding site [chemical binding]; other site 1118959003495 G4 box; other site 1118959003496 G5 box; other site 1118959003497 G1 box; other site 1118959003498 Switch I region; other site 1118959003499 G2 box; other site 1118959003500 G3 box; other site 1118959003501 Switch II region; other site 1118959003502 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1118959003503 RNA/DNA hybrid binding site [nucleotide binding]; other site 1118959003504 active site 1118959003505 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1118959003506 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1118959003507 CoA-ligase; Region: Ligase_CoA; pfam00549 1118959003508 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1118959003509 CoA binding domain; Region: CoA_binding; pfam02629 1118959003510 CoA-ligase; Region: Ligase_CoA; pfam00549 1118959003511 FemAB family; Region: FemAB; pfam02388 1118959003512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1118959003513 DNA protecting protein DprA; Region: dprA; TIGR00732 1118959003514 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1118959003515 potential frameshift: common BLAST hit: gi|150393798|ref|YP_001316473.1| DNA topoisomerase I 1118959003516 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1118959003517 active site 1118959003518 interdomain interaction site; other site 1118959003519 putative metal-binding site [ion binding]; other site 1118959003520 nucleotide binding site [chemical binding]; other site 1118959003521 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1118959003522 domain I; other site 1118959003523 phosphate binding site [ion binding]; other site 1118959003524 DNA topoisomerase I; Validated; Region: PRK05582 1118959003525 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1118959003526 domain III; other site 1118959003527 DNA binding groove [nucleotide binding] 1118959003528 catalytic site [active] 1118959003529 nucleotide binding site [chemical binding]; other site 1118959003530 domain II; other site 1118959003531 domain IV; other site 1118959003532 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1118959003533 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1118959003534 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1118959003535 Glucose inhibited division protein A; Region: GIDA; pfam01134 1118959003536 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1118959003537 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1118959003538 active site 1118959003539 DNA binding site [nucleotide binding] 1118959003540 Int/Topo IB signature motif; other site 1118959003541 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1118959003542 active site 1118959003543 HslU subunit interaction site [polypeptide binding]; other site 1118959003544 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1118959003545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959003546 Walker A motif; other site 1118959003547 ATP binding site [chemical binding]; other site 1118959003548 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1118959003549 Walker B motif; other site 1118959003550 arginine finger; other site 1118959003551 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1118959003552 transcriptional repressor CodY; Validated; Region: PRK04158 1118959003553 CodY GAF-like domain; Region: CodY; pfam06018 1118959003554 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1118959003555 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1118959003556 rRNA interaction site [nucleotide binding]; other site 1118959003557 S8 interaction site; other site 1118959003558 putative laminin-1 binding site; other site 1118959003559 elongation factor Ts; Provisional; Region: tsf; PRK09377 1118959003560 UBA/TS-N domain; Region: UBA; pfam00627 1118959003561 Elongation factor TS; Region: EF_TS; pfam00889 1118959003562 Elongation factor TS; Region: EF_TS; pfam00889 1118959003563 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1118959003564 putative nucleotide binding site [chemical binding]; other site 1118959003565 uridine monophosphate binding site [chemical binding]; other site 1118959003566 homohexameric interface [polypeptide binding]; other site 1118959003567 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1118959003568 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1118959003569 hinge region; other site 1118959003570 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1118959003571 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1118959003572 catalytic residue [active] 1118959003573 putative FPP diphosphate binding site; other site 1118959003574 putative FPP binding hydrophobic cleft; other site 1118959003575 dimer interface [polypeptide binding]; other site 1118959003576 putative IPP diphosphate binding site; other site 1118959003577 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1118959003578 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1118959003579 RIP metalloprotease RseP; Region: TIGR00054 1118959003580 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1118959003581 active site 1118959003582 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1118959003583 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1118959003584 protein binding site [polypeptide binding]; other site 1118959003585 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1118959003586 putative substrate binding region [chemical binding]; other site 1118959003587 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1118959003588 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1118959003589 dimer interface [polypeptide binding]; other site 1118959003590 motif 1; other site 1118959003591 active site 1118959003592 motif 2; other site 1118959003593 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1118959003594 putative deacylase active site [active] 1118959003595 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1118959003596 active site 1118959003597 motif 3; other site 1118959003598 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1118959003599 anticodon binding site; other site 1118959003600 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1118959003601 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1118959003602 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1118959003603 generic binding surface II; other site 1118959003604 generic binding surface I; other site 1118959003605 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1118959003606 active site 1118959003607 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1118959003608 active site 1118959003609 catalytic site [active] 1118959003610 substrate binding site [chemical binding]; other site 1118959003611 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1118959003612 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1118959003613 Sm and related proteins; Region: Sm_like; cl00259 1118959003614 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1118959003615 putative oligomer interface [polypeptide binding]; other site 1118959003616 putative RNA binding site [nucleotide binding]; other site 1118959003617 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1118959003618 NusA N-terminal domain; Region: NusA_N; pfam08529 1118959003619 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1118959003620 RNA binding site [nucleotide binding]; other site 1118959003621 homodimer interface [polypeptide binding]; other site 1118959003622 NusA-like KH domain; Region: KH_5; pfam13184 1118959003623 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1118959003624 G-X-X-G motif; other site 1118959003625 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1118959003626 putative RNA binding cleft [nucleotide binding]; other site 1118959003627 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1118959003628 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1118959003629 translation initiation factor IF-2; Region: IF-2; TIGR00487 1118959003630 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1118959003631 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1118959003632 G1 box; other site 1118959003633 putative GEF interaction site [polypeptide binding]; other site 1118959003634 GTP/Mg2+ binding site [chemical binding]; other site 1118959003635 Switch I region; other site 1118959003636 G2 box; other site 1118959003637 G3 box; other site 1118959003638 Switch II region; other site 1118959003639 G4 box; other site 1118959003640 G5 box; other site 1118959003641 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1118959003642 Translation-initiation factor 2; Region: IF-2; pfam11987 1118959003643 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1118959003644 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1118959003645 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1118959003646 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1118959003647 RNA binding site [nucleotide binding]; other site 1118959003648 active site 1118959003649 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1118959003650 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1118959003651 active site 1118959003652 Riboflavin kinase; Region: Flavokinase; smart00904 1118959003653 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1118959003654 16S/18S rRNA binding site [nucleotide binding]; other site 1118959003655 S13e-L30e interaction site [polypeptide binding]; other site 1118959003656 25S rRNA binding site [nucleotide binding]; other site 1118959003657 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1118959003658 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1118959003659 RNase E interface [polypeptide binding]; other site 1118959003660 trimer interface [polypeptide binding]; other site 1118959003661 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1118959003662 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1118959003663 RNase E interface [polypeptide binding]; other site 1118959003664 trimer interface [polypeptide binding]; other site 1118959003665 active site 1118959003666 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1118959003667 putative nucleic acid binding region [nucleotide binding]; other site 1118959003668 G-X-X-G motif; other site 1118959003669 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1118959003670 RNA binding site [nucleotide binding]; other site 1118959003671 domain interface; other site 1118959003672 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1118959003673 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1118959003674 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1118959003675 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1118959003676 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1118959003677 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1118959003678 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1118959003679 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1118959003680 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1118959003681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1118959003682 DNA-binding site [nucleotide binding]; DNA binding site 1118959003683 UTRA domain; Region: UTRA; pfam07702 1118959003684 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1118959003685 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1118959003686 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1118959003687 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1118959003688 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1118959003689 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1118959003690 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1118959003691 classical (c) SDRs; Region: SDR_c; cd05233 1118959003692 NAD(P) binding site [chemical binding]; other site 1118959003693 active site 1118959003694 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1118959003695 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1118959003696 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1118959003697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959003698 non-specific DNA binding site [nucleotide binding]; other site 1118959003699 salt bridge; other site 1118959003700 sequence-specific DNA binding site [nucleotide binding]; other site 1118959003701 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1118959003702 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1118959003703 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1118959003704 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1118959003705 putative MPT binding site; other site 1118959003706 recombinase A; Provisional; Region: recA; PRK09354 1118959003707 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1118959003708 hexamer interface [polypeptide binding]; other site 1118959003709 Walker A motif; other site 1118959003710 ATP binding site [chemical binding]; other site 1118959003711 Walker B motif; other site 1118959003712 phosphodiesterase; Provisional; Region: PRK12704 1118959003713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1118959003714 Zn2+ binding site [ion binding]; other site 1118959003715 Mg2+ binding site [ion binding]; other site 1118959003716 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1118959003717 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1118959003718 putative active site [active] 1118959003719 metal binding site [ion binding]; metal-binding site 1118959003720 homodimer binding site [polypeptide binding]; other site 1118959003721 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1118959003722 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1118959003723 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1118959003724 dimer interface [polypeptide binding]; other site 1118959003725 PYR/PP interface [polypeptide binding]; other site 1118959003726 TPP binding site [chemical binding]; other site 1118959003727 substrate binding site [chemical binding]; other site 1118959003728 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1118959003729 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1118959003730 TPP-binding site [chemical binding]; other site 1118959003731 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1118959003732 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1118959003733 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1118959003734 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1118959003735 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1118959003736 FeS/SAM binding site; other site 1118959003737 TRAM domain; Region: TRAM; pfam01938 1118959003738 Predicted membrane protein [Function unknown]; Region: COG4550 1118959003739 Predicted membrane protein [Function unknown]; Region: COG4732 1118959003740 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1118959003741 MutS domain I; Region: MutS_I; pfam01624 1118959003742 MutS domain II; Region: MutS_II; pfam05188 1118959003743 MutS domain III; Region: MutS_III; pfam05192 1118959003744 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1118959003745 Walker A/P-loop; other site 1118959003746 ATP binding site [chemical binding]; other site 1118959003747 Q-loop/lid; other site 1118959003748 ABC transporter signature motif; other site 1118959003749 Walker B; other site 1118959003750 D-loop; other site 1118959003751 H-loop/switch region; other site 1118959003752 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1118959003753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959003754 ATP binding site [chemical binding]; other site 1118959003755 Mg2+ binding site [ion binding]; other site 1118959003756 G-X-G motif; other site 1118959003757 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1118959003758 ATP binding site [chemical binding]; other site 1118959003759 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1118959003760 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 1118959003761 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1118959003762 amphipathic channel; other site 1118959003763 Asn-Pro-Ala signature motifs; other site 1118959003764 glycerol kinase; Provisional; Region: glpK; PRK00047 1118959003765 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1118959003766 N- and C-terminal domain interface [polypeptide binding]; other site 1118959003767 active site 1118959003768 MgATP binding site [chemical binding]; other site 1118959003769 catalytic site [active] 1118959003770 metal binding site [ion binding]; metal-binding site 1118959003771 glycerol binding site [chemical binding]; other site 1118959003772 homotetramer interface [polypeptide binding]; other site 1118959003773 homodimer interface [polypeptide binding]; other site 1118959003774 FBP binding site [chemical binding]; other site 1118959003775 protein IIAGlc interface [polypeptide binding]; other site 1118959003776 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1118959003777 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1118959003778 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1118959003779 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 1118959003780 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1118959003781 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1118959003782 bacterial Hfq-like; Region: Hfq; cd01716 1118959003783 hexamer interface [polypeptide binding]; other site 1118959003784 Sm1 motif; other site 1118959003785 RNA binding site [nucleotide binding]; other site 1118959003786 Sm2 motif; other site 1118959003787 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1118959003788 catalytic residues [active] 1118959003789 dimer interface [polypeptide binding]; other site 1118959003790 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1118959003791 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1118959003792 HflX GTPase family; Region: HflX; cd01878 1118959003793 G1 box; other site 1118959003794 GTP/Mg2+ binding site [chemical binding]; other site 1118959003795 Switch I region; other site 1118959003796 G2 box; other site 1118959003797 G3 box; other site 1118959003798 Switch II region; other site 1118959003799 G4 box; other site 1118959003800 G5 box; other site 1118959003801 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1118959003802 Aluminium resistance protein; Region: Alum_res; pfam06838 1118959003803 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1118959003804 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1118959003805 DNA binding residues [nucleotide binding] 1118959003806 putative dimer interface [polypeptide binding]; other site 1118959003807 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1118959003808 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1118959003809 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1118959003810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1118959003811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1118959003812 potential frameshift: common BLAST hit: gi|319892860|ref|YP_004149735.1| phage minor head protein 1118959003813 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1118959003814 Sm and related proteins; Region: Sm_like; cl00259 1118959003815 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1118959003816 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1118959003817 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1118959003818 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1118959003819 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1118959003820 catalytic residue [active] 1118959003821 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1118959003822 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1118959003823 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1118959003824 putative active site [active] 1118959003825 catalytic site [active] 1118959003826 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1118959003827 putative active site [active] 1118959003828 catalytic site [active] 1118959003829 Staphylococcal nuclease homologues; Region: SNc; smart00318 1118959003830 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1118959003831 Catalytic site; other site 1118959003832 AAA domain; Region: AAA_11; pfam13086 1118959003833 aspartate kinase; Reviewed; Region: PRK09034 1118959003834 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1118959003835 putative catalytic residues [active] 1118959003836 putative nucleotide binding site [chemical binding]; other site 1118959003837 putative aspartate binding site [chemical binding]; other site 1118959003838 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1118959003839 allosteric regulatory residue; other site 1118959003840 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1118959003841 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1118959003842 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1118959003843 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1118959003844 threonine synthase; Reviewed; Region: PRK06721 1118959003845 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1118959003846 homodimer interface [polypeptide binding]; other site 1118959003847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959003848 catalytic residue [active] 1118959003849 homoserine kinase; Provisional; Region: PRK01212 1118959003850 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1118959003851 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1118959003852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959003853 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1118959003854 active site 1118959003855 motif I; other site 1118959003856 motif II; other site 1118959003857 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1118959003858 lysine transporter; Provisional; Region: PRK10836 1118959003859 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1118959003860 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1118959003861 tetramer interface [polypeptide binding]; other site 1118959003862 heme binding pocket [chemical binding]; other site 1118959003863 NADPH binding site [chemical binding]; other site 1118959003864 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1118959003865 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1118959003866 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1118959003867 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1118959003868 active site 1118959003869 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1118959003870 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1118959003871 LexA repressor; Validated; Region: PRK00215 1118959003872 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1118959003873 putative DNA binding site [nucleotide binding]; other site 1118959003874 putative Zn2+ binding site [ion binding]; other site 1118959003875 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1118959003876 Catalytic site [active] 1118959003877 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1118959003878 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1118959003879 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1118959003880 TPP-binding site [chemical binding]; other site 1118959003881 dimer interface [polypeptide binding]; other site 1118959003882 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1118959003883 PYR/PP interface [polypeptide binding]; other site 1118959003884 dimer interface [polypeptide binding]; other site 1118959003885 TPP binding site [chemical binding]; other site 1118959003886 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1118959003887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1118959003888 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1118959003889 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1118959003890 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1118959003891 active site 1118959003892 metal binding site [ion binding]; metal-binding site 1118959003893 DNA binding site [nucleotide binding] 1118959003894 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1118959003895 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1118959003896 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1118959003897 Walker A/P-loop; other site 1118959003898 ATP binding site [chemical binding]; other site 1118959003899 Q-loop/lid; other site 1118959003900 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1118959003901 ABC transporter signature motif; other site 1118959003902 Walker B; other site 1118959003903 D-loop; other site 1118959003904 H-loop/switch region; other site 1118959003905 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1118959003906 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1118959003907 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1118959003908 aconitate hydratase; Validated; Region: PRK09277 1118959003909 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1118959003910 substrate binding site [chemical binding]; other site 1118959003911 ligand binding site [chemical binding]; other site 1118959003912 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1118959003913 substrate binding site [chemical binding]; other site 1118959003914 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1118959003915 active site 1118959003916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1118959003917 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1118959003918 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1118959003919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959003920 ATP binding site [chemical binding]; other site 1118959003921 Mg2+ binding site [ion binding]; other site 1118959003922 G-X-G motif; other site 1118959003923 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1118959003924 anchoring element; other site 1118959003925 dimer interface [polypeptide binding]; other site 1118959003926 ATP binding site [chemical binding]; other site 1118959003927 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1118959003928 active site 1118959003929 putative metal-binding site [ion binding]; other site 1118959003930 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1118959003931 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1118959003932 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1118959003933 CAP-like domain; other site 1118959003934 active site 1118959003935 primary dimer interface [polypeptide binding]; other site 1118959003936 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1118959003937 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1118959003938 amino acid carrier protein; Region: agcS; TIGR00835 1118959003939 CAT RNA binding domain; Region: CAT_RBD; smart01061 1118959003940 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1118959003941 PRD domain; Region: PRD; pfam00874 1118959003942 PRD domain; Region: PRD; pfam00874 1118959003943 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1118959003944 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1118959003945 Predicted integral membrane protein [Function unknown]; Region: COG0392 1118959003946 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1118959003947 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1118959003948 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1118959003949 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1118959003950 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1118959003951 active site 1 [active] 1118959003952 dimer interface [polypeptide binding]; other site 1118959003953 hexamer interface [polypeptide binding]; other site 1118959003954 active site 2 [active] 1118959003955 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1118959003956 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1118959003957 active site 1118959003958 DNA binding site [nucleotide binding] 1118959003959 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1118959003960 prephenate dehydrogenase; Validated; Region: PRK06545 1118959003961 prephenate dehydrogenase; Validated; Region: PRK08507 1118959003962 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1118959003963 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1118959003964 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1118959003965 putative oligomer interface [polypeptide binding]; other site 1118959003966 putative active site [active] 1118959003967 metal binding site [ion binding]; metal-binding site 1118959003968 anthranilate synthase component I; Provisional; Region: PRK13567 1118959003969 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1118959003970 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1118959003971 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1118959003972 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1118959003973 glutamine binding [chemical binding]; other site 1118959003974 catalytic triad [active] 1118959003975 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1118959003976 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1118959003977 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1118959003978 active site 1118959003979 ribulose/triose binding site [chemical binding]; other site 1118959003980 substrate (anthranilate) binding pocket [chemical binding]; other site 1118959003981 product (indole) binding pocket [chemical binding]; other site 1118959003982 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1118959003983 active site 1118959003984 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1118959003985 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1118959003986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959003987 catalytic residue [active] 1118959003988 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1118959003989 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1118959003990 substrate binding site [chemical binding]; other site 1118959003991 active site 1118959003992 catalytic residues [active] 1118959003993 heterodimer interface [polypeptide binding]; other site 1118959003994 FemAB family; Region: FemAB; pfam02388 1118959003995 FlxA-like protein; Region: FlxA; pfam14282 1118959003996 FemAB family; Region: FemAB; pfam02388 1118959003997 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1118959003998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959003999 active site 1118959004000 motif I; other site 1118959004001 motif II; other site 1118959004002 SWIM zinc finger; Region: SWIM; pfam04434 1118959004003 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1118959004004 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1118959004005 Walker A/P-loop; other site 1118959004006 ATP binding site [chemical binding]; other site 1118959004007 Q-loop/lid; other site 1118959004008 ABC transporter signature motif; other site 1118959004009 Walker B; other site 1118959004010 D-loop; other site 1118959004011 H-loop/switch region; other site 1118959004012 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1118959004013 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1118959004014 Walker A/P-loop; other site 1118959004015 ATP binding site [chemical binding]; other site 1118959004016 Q-loop/lid; other site 1118959004017 ABC transporter signature motif; other site 1118959004018 Walker B; other site 1118959004019 D-loop; other site 1118959004020 H-loop/switch region; other site 1118959004021 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1118959004022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959004023 dimer interface [polypeptide binding]; other site 1118959004024 conserved gate region; other site 1118959004025 putative PBP binding loops; other site 1118959004026 ABC-ATPase subunit interface; other site 1118959004027 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1118959004028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959004029 dimer interface [polypeptide binding]; other site 1118959004030 conserved gate region; other site 1118959004031 putative PBP binding loops; other site 1118959004032 ABC-ATPase subunit interface; other site 1118959004033 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1118959004034 oligoendopeptidase F; Region: pepF; TIGR00181 1118959004035 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1118959004036 active site 1118959004037 Zn binding site [ion binding]; other site 1118959004038 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1118959004039 PhoU domain; Region: PhoU; pfam01895 1118959004040 PhoU domain; Region: PhoU; pfam01895 1118959004041 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1118959004042 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1118959004043 Walker A/P-loop; other site 1118959004044 ATP binding site [chemical binding]; other site 1118959004045 Q-loop/lid; other site 1118959004046 ABC transporter signature motif; other site 1118959004047 Walker B; other site 1118959004048 D-loop; other site 1118959004049 H-loop/switch region; other site 1118959004050 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1118959004051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959004052 dimer interface [polypeptide binding]; other site 1118959004053 conserved gate region; other site 1118959004054 putative PBP binding loops; other site 1118959004055 ABC-ATPase subunit interface; other site 1118959004056 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1118959004057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959004058 dimer interface [polypeptide binding]; other site 1118959004059 conserved gate region; other site 1118959004060 ABC-ATPase subunit interface; other site 1118959004061 phosphate binding protein; Region: ptsS_2; TIGR02136 1118959004062 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1118959004063 S1 domain; Region: S1_2; pfam13509 1118959004064 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1118959004065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1118959004066 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1118959004067 ABC transporter; Region: ABC_tran_2; pfam12848 1118959004068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1118959004069 aspartate kinase; Reviewed; Region: PRK06635 1118959004070 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1118959004071 putative nucleotide binding site [chemical binding]; other site 1118959004072 putative catalytic residues [active] 1118959004073 putative Mg ion binding site [ion binding]; other site 1118959004074 putative aspartate binding site [chemical binding]; other site 1118959004075 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1118959004076 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1118959004077 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1118959004078 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1118959004079 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1118959004080 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1118959004081 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1118959004082 dimer interface [polypeptide binding]; other site 1118959004083 active site 1118959004084 catalytic residue [active] 1118959004085 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1118959004086 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1118959004087 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1118959004088 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1118959004089 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1118959004090 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1118959004091 active site 1118959004092 trimer interface [polypeptide binding]; other site 1118959004093 substrate binding site [chemical binding]; other site 1118959004094 CoA binding site [chemical binding]; other site 1118959004095 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1118959004096 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1118959004097 metal binding site [ion binding]; metal-binding site 1118959004098 dimer interface [polypeptide binding]; other site 1118959004099 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1118959004100 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1118959004101 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1118959004102 catalytic residue [active] 1118959004103 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1118959004104 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1118959004105 active site 1118959004106 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1118959004107 substrate binding site [chemical binding]; other site 1118959004108 catalytic residues [active] 1118959004109 dimer interface [polypeptide binding]; other site 1118959004110 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1118959004111 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1118959004112 DNA-binding site [nucleotide binding]; DNA binding site 1118959004113 RNA-binding motif; other site 1118959004114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 1118959004115 acylphosphatase; Provisional; Region: PRK14431 1118959004116 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1118959004117 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1118959004118 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1118959004119 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1118959004120 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1118959004121 metal ion-dependent adhesion site (MIDAS); other site 1118959004122 MoxR-like ATPases [General function prediction only]; Region: COG0714 1118959004123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959004124 Walker A motif; other site 1118959004125 ATP binding site [chemical binding]; other site 1118959004126 Walker B motif; other site 1118959004127 arginine finger; other site 1118959004128 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1118959004129 active site 1118959004130 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1118959004131 active site 1118959004132 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1118959004133 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1118959004134 E3 interaction surface; other site 1118959004135 lipoyl attachment site [posttranslational modification]; other site 1118959004136 e3 binding domain; Region: E3_binding; pfam02817 1118959004137 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1118959004138 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1118959004139 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1118959004140 TPP-binding site [chemical binding]; other site 1118959004141 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1118959004142 potential frameshift: common BLAST hit: gi|269203037|ref|YP_003282306.1| sensor histidine kinase ArlS 1118959004143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1118959004144 HAMP domain; Region: HAMP; pfam00672 1118959004145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1118959004146 dimer interface [polypeptide binding]; other site 1118959004147 phosphorylation site [posttranslational modification] 1118959004148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959004149 ATP binding site [chemical binding]; other site 1118959004150 Mg2+ binding site [ion binding]; other site 1118959004151 G-X-G motif; other site 1118959004152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1118959004153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959004154 active site 1118959004155 phosphorylation site [posttranslational modification] 1118959004156 intermolecular recognition site; other site 1118959004157 dimerization interface [polypeptide binding]; other site 1118959004158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1118959004159 DNA binding site [nucleotide binding] 1118959004160 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1118959004161 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1118959004162 active site 1118959004163 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1118959004164 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1118959004165 active site 1118959004166 homodimer interface [polypeptide binding]; other site 1118959004167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959004168 Coenzyme A binding pocket [chemical binding]; other site 1118959004169 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1118959004170 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1118959004171 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1118959004172 protein binding site [polypeptide binding]; other site 1118959004173 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1118959004174 Catalytic dyad [active] 1118959004175 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1118959004176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 1118959004177 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1118959004178 HPr interaction site; other site 1118959004179 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1118959004180 active site 1118959004181 phosphorylation site [posttranslational modification] 1118959004182 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1118959004183 SelR domain; Region: SelR; pfam01641 1118959004184 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1118959004185 EDD domain protein, DegV family; Region: DegV; TIGR00762 1118959004186 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1118959004187 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1118959004188 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1118959004189 folate binding site [chemical binding]; other site 1118959004190 NADP+ binding site [chemical binding]; other site 1118959004191 thymidylate synthase; Region: thym_sym; TIGR03284 1118959004192 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1118959004193 dimerization interface [polypeptide binding]; other site 1118959004194 active site 1118959004195 Disulphide isomerase; Region: Disulph_isomer; cl05813 1118959004196 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1118959004197 Virulence factor; Region: Virulence_fact; pfam13769 1118959004198 HEAT repeats; Region: HEAT_2; pfam13646 1118959004199 HEAT repeat; Region: HEAT; pfam02985 1118959004200 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1118959004201 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1118959004202 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1118959004203 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1118959004204 RNA/DNA hybrid binding site [nucleotide binding]; other site 1118959004205 active site 1118959004206 potential frameshift: common BLAST hit: gi|87161956|ref|YP_494024.1| cell surface protein 1118959004207 GA module; Region: GA; smart00844 1118959004208 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1118959004209 GA module; Region: GA; smart00844 1118959004210 GA module; Region: GA; smart00844 1118959004211 GA module; Region: GA; smart00844 1118959004212 GA module; Region: GA; smart00844 1118959004213 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959004214 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959004215 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959004216 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959004217 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1118959004218 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1118959004219 GA module; Region: GA; smart00844 1118959004220 GA module; Region: GA; smart00844 1118959004221 GA module; Region: GA; smart00844 1118959004222 GA module; Region: GA; smart00844 1118959004223 GA module; Region: GA; smart00844 1118959004224 GA module; Region: GA; smart00844 1118959004225 GA module; Region: GA; smart00844 1118959004226 GA module; Region: GA; smart00844 1118959004227 Predicted membrane protein [Function unknown]; Region: COG1511 1118959004228 GA module; Region: GA; smart00844 1118959004229 GA module; Region: GA; smart00844 1118959004230 GA module; Region: GA; smart00844 1118959004231 GA module; Region: GA; smart00844 1118959004232 GA module; Region: GA; smart00844 1118959004233 GA module; Region: GA; smart00844 1118959004234 GA module; Region: GA; smart00844 1118959004235 GA module; Region: GA; smart00844 1118959004236 GA module; Region: GA; smart00844 1118959004237 GA module; Region: GA; smart00844 1118959004238 GA module; Region: GA; smart00844 1118959004239 GA module; Region: GA; smart00844 1118959004240 GA module; Region: GA; pfam01468 1118959004241 GA module; Region: GA; smart00844 1118959004242 GA module; Region: GA; smart00844 1118959004243 GA module; Region: GA; smart00844 1118959004244 GA module; Region: GA; smart00844 1118959004245 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1118959004246 GA module; Region: GA; smart00844 1118959004247 GA module; Region: GA; smart00844 1118959004248 GA module; Region: GA; pfam01468 1118959004249 GA module; Region: GA; smart00844 1118959004250 GA module; Region: GA; smart00844 1118959004251 GA module; Region: GA; smart00844 1118959004252 GA module; Region: GA; smart00844 1118959004253 GA module; Region: GA; pfam01468 1118959004254 GA module; Region: GA; smart00844 1118959004255 GA module; Region: GA; smart00844 1118959004256 GA module; Region: GA; smart00844 1118959004257 GA module; Region: GA; smart00844 1118959004258 GA module; Region: GA; smart00844 1118959004259 GA module; Region: GA; smart00844 1118959004260 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1118959004261 Amino acid permease; Region: AA_permease_2; pfam13520 1118959004262 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1118959004263 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1118959004264 tetramer interface [polypeptide binding]; other site 1118959004265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959004266 catalytic residue [active] 1118959004267 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1118959004268 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1118959004269 hexamer interface [polypeptide binding]; other site 1118959004270 ligand binding site [chemical binding]; other site 1118959004271 putative active site [active] 1118959004272 NAD(P) binding site [chemical binding]; other site 1118959004273 5'-3' exonuclease; Region: 53EXOc; smart00475 1118959004274 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1118959004275 active site 1118959004276 metal binding site 1 [ion binding]; metal-binding site 1118959004277 putative 5' ssDNA interaction site; other site 1118959004278 metal binding site 3; metal-binding site 1118959004279 metal binding site 2 [ion binding]; metal-binding site 1118959004280 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1118959004281 putative DNA binding site [nucleotide binding]; other site 1118959004282 putative metal binding site [ion binding]; other site 1118959004283 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1118959004284 Dynamin family; Region: Dynamin_N; pfam00350 1118959004285 G1 box; other site 1118959004286 GTP/Mg2+ binding site [chemical binding]; other site 1118959004287 G2 box; other site 1118959004288 Switch I region; other site 1118959004289 G3 box; other site 1118959004290 Switch II region; other site 1118959004291 G4 box; other site 1118959004292 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1118959004293 Dynamin family; Region: Dynamin_N; pfam00350 1118959004294 G1 box; other site 1118959004295 GTP/Mg2+ binding site [chemical binding]; other site 1118959004296 G2 box; other site 1118959004297 Switch I region; other site 1118959004298 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1118959004299 G3 box; other site 1118959004300 Switch II region; other site 1118959004301 GTP/Mg2+ binding site [chemical binding]; other site 1118959004302 G4 box; other site 1118959004303 G5 box; other site 1118959004304 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1118959004305 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1118959004306 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1118959004307 Cobalt transport protein component CbiN; Region: CbiN; cl00842 1118959004308 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1118959004309 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1118959004310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1118959004311 cell division protein GpsB; Provisional; Region: PRK14127 1118959004312 DivIVA domain; Region: DivI1A_domain; TIGR03544 1118959004313 hypothetical protein; Provisional; Region: PRK13660 1118959004314 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1118959004315 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1118959004316 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1118959004317 Transglycosylase; Region: Transgly; pfam00912 1118959004318 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1118959004319 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1118959004320 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1118959004321 minor groove reading motif; other site 1118959004322 helix-hairpin-helix signature motif; other site 1118959004323 substrate binding pocket [chemical binding]; other site 1118959004324 active site 1118959004325 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1118959004326 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1118959004327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1118959004328 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1118959004329 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1118959004330 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1118959004331 putative dimer interface [polypeptide binding]; other site 1118959004332 putative anticodon binding site; other site 1118959004333 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1118959004334 homodimer interface [polypeptide binding]; other site 1118959004335 motif 1; other site 1118959004336 motif 2; other site 1118959004337 active site 1118959004338 motif 3; other site 1118959004339 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1118959004340 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1118959004341 active site 1118959004342 catalytic site [active] 1118959004343 substrate binding site [chemical binding]; other site 1118959004344 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1118959004345 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1118959004346 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1118959004347 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1118959004348 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1118959004349 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1118959004350 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1118959004351 active site 1118959004352 NTP binding site [chemical binding]; other site 1118959004353 metal binding triad [ion binding]; metal-binding site 1118959004354 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1118959004355 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1118959004356 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1118959004357 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1118959004358 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1118959004359 homodimer interface [polypeptide binding]; other site 1118959004360 metal binding site [ion binding]; metal-binding site 1118959004361 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1118959004362 Predicted membrane protein [Function unknown]; Region: COG4347 1118959004363 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1118959004364 UPF0302 domain; Region: UPF0302; pfam08864 1118959004365 A short protein domain of unknown function; Region: IDEAL; smart00914 1118959004366 TPR repeat; Region: TPR_11; pfam13414 1118959004367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1118959004368 binding surface 1118959004369 TPR motif; other site 1118959004370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1118959004371 TPR motif; other site 1118959004372 binding surface 1118959004373 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1118959004374 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1118959004375 hinge; other site 1118959004376 active site 1118959004377 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1118959004378 active site 1118959004379 NAD binding site [chemical binding]; other site 1118959004380 metal binding site [ion binding]; metal-binding site 1118959004381 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1118959004382 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1118959004383 Tetramer interface [polypeptide binding]; other site 1118959004384 active site 1118959004385 FMN-binding site [chemical binding]; other site 1118959004386 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1118959004387 active site 1118959004388 multimer interface [polypeptide binding]; other site 1118959004389 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1118959004390 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1118959004391 substrate binding pocket [chemical binding]; other site 1118959004392 chain length determination region; other site 1118959004393 substrate-Mg2+ binding site; other site 1118959004394 catalytic residues [active] 1118959004395 aspartate-rich region 1; other site 1118959004396 active site lid residues [active] 1118959004397 aspartate-rich region 2; other site 1118959004398 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1118959004399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959004400 S-adenosylmethionine binding site [chemical binding]; other site 1118959004401 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1118959004402 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1118959004403 IHF dimer interface [polypeptide binding]; other site 1118959004404 IHF - DNA interface [nucleotide binding]; other site 1118959004405 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1118959004406 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1118959004407 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1118959004408 GTP-binding protein Der; Reviewed; Region: PRK00093 1118959004409 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1118959004410 G1 box; other site 1118959004411 GTP/Mg2+ binding site [chemical binding]; other site 1118959004412 Switch I region; other site 1118959004413 G2 box; other site 1118959004414 Switch II region; other site 1118959004415 G3 box; other site 1118959004416 G4 box; other site 1118959004417 G5 box; other site 1118959004418 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1118959004419 G1 box; other site 1118959004420 GTP/Mg2+ binding site [chemical binding]; other site 1118959004421 Switch I region; other site 1118959004422 G2 box; other site 1118959004423 G3 box; other site 1118959004424 Switch II region; other site 1118959004425 G4 box; other site 1118959004426 G5 box; other site 1118959004427 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1118959004428 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1118959004429 RNA binding site [nucleotide binding]; other site 1118959004430 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1118959004431 RNA binding site [nucleotide binding]; other site 1118959004432 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1118959004433 RNA binding site [nucleotide binding]; other site 1118959004434 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1118959004435 RNA binding site [nucleotide binding]; other site 1118959004436 cytidylate kinase; Provisional; Region: cmk; PRK00023 1118959004437 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1118959004438 CMP-binding site; other site 1118959004439 The sites determining sugar specificity; other site 1118959004440 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1118959004441 active site 1118959004442 homotetramer interface [polypeptide binding]; other site 1118959004443 homodimer interface [polypeptide binding]; other site 1118959004444 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1118959004445 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1118959004446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959004447 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1118959004448 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1118959004449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1118959004450 ATP binding site [chemical binding]; other site 1118959004451 putative Mg++ binding site [ion binding]; other site 1118959004452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1118959004453 nucleotide binding region [chemical binding]; other site 1118959004454 ATP-binding site [chemical binding]; other site 1118959004455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1118959004456 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1118959004457 Predicted membrane protein [Function unknown]; Region: COG3601 1118959004458 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1118959004459 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1118959004460 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1118959004461 prophage 1118959004462 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1118959004463 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1118959004464 CHAP domain; Region: CHAP; pfam05257 1118959004465 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1118959004466 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1118959004467 active site 1118959004468 metal binding site [ion binding]; metal-binding site 1118959004469 Bacterial SH3 domain; Region: SH3_5; pfam08460 1118959004470 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1118959004471 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1118959004472 Ligand-gated ion channel; Region: Lig_chan; pfam00060 1118959004473 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1118959004474 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1118959004475 Phage tail protein; Region: Sipho_tail; cl17486 1118959004476 Phage tail protein; Region: Sipho_tail; cl17486 1118959004477 Phage-related minor tail protein [Function unknown]; Region: COG5280 1118959004478 Phage-related protein [Function unknown]; Region: COG5412 1118959004479 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 1118959004480 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1118959004481 Peptidase family M23; Region: Peptidase_M23; pfam01551 1118959004482 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1118959004483 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1118959004484 catalytic residue [active] 1118959004485 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1118959004486 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1118959004487 Translocation protein Sec62; Region: Sec62; cl02170 1118959004488 Phage capsid family; Region: Phage_capsid; pfam05065 1118959004489 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1118959004490 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1118959004491 oligomer interface [polypeptide binding]; other site 1118959004492 active site residues [active] 1118959004493 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1118959004494 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1118959004495 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1118959004496 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1118959004497 HNH endonuclease; Region: HNH; pfam01844 1118959004498 active site 1118959004499 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1118959004500 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1118959004501 Transcriptional activator RinB; Region: RinB; pfam06116 1118959004502 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1118959004503 dUTPase; Region: dUTPase_2; pfam08761 1118959004504 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1118959004505 active site 1118959004506 homodimer interface [polypeptide binding]; other site 1118959004507 metal binding site [ion binding]; metal-binding site 1118959004508 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1118959004509 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1118959004510 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1118959004511 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 1118959004512 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1118959004513 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 1118959004514 hypothetical protein; Validated; Region: PRK08116 1118959004515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959004516 Walker A motif; other site 1118959004517 ATP binding site [chemical binding]; other site 1118959004518 Walker B motif; other site 1118959004519 Helix-turn-helix domain; Region: HTH_36; pfam13730 1118959004520 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 1118959004521 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1118959004522 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1118959004523 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1118959004524 dimer interface [polypeptide binding]; other site 1118959004525 ssDNA binding site [nucleotide binding]; other site 1118959004526 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1118959004527 ERF superfamily; Region: ERF; pfam04404 1118959004528 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 1118959004529 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1118959004530 Homeodomain-like domain; Region: HTH_23; pfam13384 1118959004531 Phage anti-repressor protein [Transcription]; Region: COG3561 1118959004532 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1118959004533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959004534 salt bridge; other site 1118959004535 non-specific DNA binding site [nucleotide binding]; other site 1118959004536 sequence-specific DNA binding site [nucleotide binding]; other site 1118959004537 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1118959004538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959004539 non-specific DNA binding site [nucleotide binding]; other site 1118959004540 salt bridge; other site 1118959004541 sequence-specific DNA binding site [nucleotide binding]; other site 1118959004542 Predicted transcriptional regulator [Transcription]; Region: COG2932 1118959004543 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1118959004544 Catalytic site [active] 1118959004545 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1118959004546 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1118959004547 Int/Topo IB signature motif; other site 1118959004548 AAA domain; Region: AAA_13; pfam13166 1118959004549 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1118959004550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1118959004551 dimerization interface [polypeptide binding]; other site 1118959004552 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1118959004553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1118959004554 dimer interface [polypeptide binding]; other site 1118959004555 phosphorylation site [posttranslational modification] 1118959004556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959004557 ATP binding site [chemical binding]; other site 1118959004558 Mg2+ binding site [ion binding]; other site 1118959004559 G-X-G motif; other site 1118959004560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1118959004561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959004562 active site 1118959004563 phosphorylation site [posttranslational modification] 1118959004564 intermolecular recognition site; other site 1118959004565 dimerization interface [polypeptide binding]; other site 1118959004566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1118959004567 DNA binding site [nucleotide binding] 1118959004568 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1118959004569 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1118959004570 RNA binding surface [nucleotide binding]; other site 1118959004571 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1118959004572 active site 1118959004573 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1118959004574 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1118959004575 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1118959004576 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1118959004577 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1118959004578 active site 1118959004579 Int/Topo IB signature motif; other site 1118959004580 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1118959004581 metal binding site 2 [ion binding]; metal-binding site 1118959004582 putative DNA binding helix; other site 1118959004583 metal binding site 1 [ion binding]; metal-binding site 1118959004584 dimer interface [polypeptide binding]; other site 1118959004585 structural Zn2+ binding site [ion binding]; other site 1118959004586 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1118959004587 dimer interface [polypeptide binding]; other site 1118959004588 ADP-ribose binding site [chemical binding]; other site 1118959004589 active site 1118959004590 nudix motif; other site 1118959004591 metal binding site [ion binding]; metal-binding site 1118959004592 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1118959004593 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1118959004594 active site 1118959004595 catalytic tetrad [active] 1118959004596 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1118959004597 classical (c) SDRs; Region: SDR_c; cd05233 1118959004598 NAD(P) binding site [chemical binding]; other site 1118959004599 active site 1118959004600 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1118959004601 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1118959004602 ribonuclease Z; Region: RNase_Z; TIGR02651 1118959004603 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1118959004604 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1118959004605 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1118959004606 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1118959004607 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1118959004608 potential frameshift: common BLAST hit: gi|87160385|ref|YP_494152.1| alpha-D-1,4-glucosidase 1118959004609 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1118959004610 active site 1118959004611 catalytic site [active] 1118959004612 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1118959004613 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1118959004614 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1118959004615 DNA binding site [nucleotide binding] 1118959004616 domain linker motif; other site 1118959004617 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1118959004618 putative ligand binding site [chemical binding]; other site 1118959004619 putative dimerization interface [polypeptide binding]; other site 1118959004620 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1118959004621 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1118959004622 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1118959004623 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1118959004624 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1118959004625 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1118959004626 peptidase T-like protein; Region: PepT-like; TIGR01883 1118959004627 metal binding site [ion binding]; metal-binding site 1118959004628 putative dimer interface [polypeptide binding]; other site 1118959004629 Predicted membrane protein [Function unknown]; Region: COG4129 1118959004630 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1118959004631 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1118959004632 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1118959004633 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1118959004634 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1118959004635 E3 interaction surface; other site 1118959004636 lipoyl attachment site [posttranslational modification]; other site 1118959004637 e3 binding domain; Region: E3_binding; pfam02817 1118959004638 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1118959004639 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1118959004640 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1118959004641 alpha subunit interface [polypeptide binding]; other site 1118959004642 TPP binding site [chemical binding]; other site 1118959004643 heterodimer interface [polypeptide binding]; other site 1118959004644 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1118959004645 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1118959004646 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1118959004647 tetramer interface [polypeptide binding]; other site 1118959004648 TPP-binding site [chemical binding]; other site 1118959004649 heterodimer interface [polypeptide binding]; other site 1118959004650 phosphorylation loop region [posttranslational modification] 1118959004651 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1118959004652 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1118959004653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959004654 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1118959004655 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1118959004656 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1118959004657 Walker A/P-loop; other site 1118959004658 ATP binding site [chemical binding]; other site 1118959004659 Q-loop/lid; other site 1118959004660 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1118959004661 ABC transporter signature motif; other site 1118959004662 Walker B; other site 1118959004663 D-loop; other site 1118959004664 H-loop/switch region; other site 1118959004665 arginine repressor; Provisional; Region: PRK04280 1118959004666 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1118959004667 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1118959004668 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1118959004669 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1118959004670 substrate binding pocket [chemical binding]; other site 1118959004671 chain length determination region; other site 1118959004672 substrate-Mg2+ binding site; other site 1118959004673 catalytic residues [active] 1118959004674 aspartate-rich region 1; other site 1118959004675 active site lid residues [active] 1118959004676 aspartate-rich region 2; other site 1118959004677 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1118959004678 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1118959004679 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1118959004680 generic binding surface II; other site 1118959004681 generic binding surface I; other site 1118959004682 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1118959004683 putative RNA binding site [nucleotide binding]; other site 1118959004684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1118959004685 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1118959004686 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1118959004687 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1118959004688 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1118959004689 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1118959004690 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1118959004691 carboxyltransferase (CT) interaction site; other site 1118959004692 biotinylation site [posttranslational modification]; other site 1118959004693 elongation factor P; Validated; Region: PRK00529 1118959004694 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1118959004695 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1118959004696 RNA binding site [nucleotide binding]; other site 1118959004697 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1118959004698 RNA binding site [nucleotide binding]; other site 1118959004699 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1118959004700 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1118959004701 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1118959004702 active site 1118959004703 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1118959004704 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1118959004705 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1118959004706 active site residue [active] 1118959004707 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1118959004708 tetramer interface [polypeptide binding]; other site 1118959004709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959004710 catalytic residue [active] 1118959004711 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1118959004712 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1118959004713 tetramer interface [polypeptide binding]; other site 1118959004714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959004715 catalytic residue [active] 1118959004716 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1118959004717 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1118959004718 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1118959004719 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1118959004720 ADP binding site [chemical binding]; other site 1118959004721 magnesium binding site [ion binding]; other site 1118959004722 putative shikimate binding site; other site 1118959004723 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1118959004724 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1118959004725 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1118959004726 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1118959004727 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1118959004728 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1118959004729 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1118959004730 Type II/IV secretion system protein; Region: T2SE; pfam00437 1118959004731 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1118959004732 Walker A motif; other site 1118959004733 ATP binding site [chemical binding]; other site 1118959004734 Walker B motif; other site 1118959004735 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1118959004736 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1118959004737 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1118959004738 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1118959004739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1118959004740 Rhomboid family; Region: Rhomboid; pfam01694 1118959004741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1118959004742 binding surface 1118959004743 TPR motif; other site 1118959004744 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1118959004745 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1118959004746 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1118959004747 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1118959004748 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1118959004749 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1118959004750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1118959004751 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1118959004752 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1118959004753 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1118959004754 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1118959004755 metal binding site 2 [ion binding]; metal-binding site 1118959004756 putative DNA binding helix; other site 1118959004757 metal binding site 1 [ion binding]; metal-binding site 1118959004758 dimer interface [polypeptide binding]; other site 1118959004759 structural Zn2+ binding site [ion binding]; other site 1118959004760 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1118959004761 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959004762 ABC-ATPase subunit interface; other site 1118959004763 dimer interface [polypeptide binding]; other site 1118959004764 putative PBP binding regions; other site 1118959004765 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1118959004766 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1118959004767 endonuclease IV; Provisional; Region: PRK01060 1118959004768 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1118959004769 AP (apurinic/apyrimidinic) site pocket; other site 1118959004770 DNA interaction; other site 1118959004771 Metal-binding active site; metal-binding site 1118959004772 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1118959004773 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1118959004774 ATP binding site [chemical binding]; other site 1118959004775 Mg++ binding site [ion binding]; other site 1118959004776 motif III; other site 1118959004777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1118959004778 nucleotide binding region [chemical binding]; other site 1118959004779 ATP-binding site [chemical binding]; other site 1118959004780 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1118959004781 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1118959004782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1118959004783 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1118959004784 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1118959004785 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1118959004786 Family of unknown function (DUF633); Region: DUF633; pfam04816 1118959004787 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1118959004788 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1118959004789 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1118959004790 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1118959004791 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1118959004792 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1118959004793 DNA binding residues [nucleotide binding] 1118959004794 DNA primase, catalytic core; Region: dnaG; TIGR01391 1118959004795 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1118959004796 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1118959004797 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1118959004798 active site 1118959004799 metal binding site [ion binding]; metal-binding site 1118959004800 interdomain interaction site; other site 1118959004801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1118959004802 HTH domain; Region: HTH_11; cl17392 1118959004803 FOG: CBS domain [General function prediction only]; Region: COG0517 1118959004804 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1118959004805 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1118959004806 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1118959004807 motif 1; other site 1118959004808 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1118959004809 active site 1118959004810 motif 2; other site 1118959004811 motif 3; other site 1118959004812 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1118959004813 anticodon binding site; other site 1118959004814 DNA repair protein RecO; Region: reco; TIGR00613 1118959004815 Recombination protein O N terminal; Region: RecO_N; pfam11967 1118959004816 Recombination protein O C terminal; Region: RecO_C; pfam02565 1118959004817 GTPase Era; Reviewed; Region: era; PRK00089 1118959004818 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1118959004819 G1 box; other site 1118959004820 GTP/Mg2+ binding site [chemical binding]; other site 1118959004821 Switch I region; other site 1118959004822 G2 box; other site 1118959004823 Switch II region; other site 1118959004824 G3 box; other site 1118959004825 G4 box; other site 1118959004826 G5 box; other site 1118959004827 KH domain; Region: KH_2; pfam07650 1118959004828 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1118959004829 active site 1118959004830 catalytic motif [active] 1118959004831 Zn binding site [ion binding]; other site 1118959004832 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1118959004833 metal-binding heat shock protein; Provisional; Region: PRK00016 1118959004834 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1118959004835 PhoH-like protein; Region: PhoH; pfam02562 1118959004836 hypothetical protein; Provisional; Region: PRK13665 1118959004837 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1118959004838 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1118959004839 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1118959004840 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1118959004841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1118959004842 FeS/SAM binding site; other site 1118959004843 TRAM domain; Region: TRAM; cl01282 1118959004844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1118959004845 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1118959004846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959004847 S-adenosylmethionine binding site [chemical binding]; other site 1118959004848 chaperone protein DnaJ; Provisional; Region: PRK14280 1118959004849 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1118959004850 HSP70 interaction site [polypeptide binding]; other site 1118959004851 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1118959004852 substrate binding site [polypeptide binding]; other site 1118959004853 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1118959004854 Zn binding sites [ion binding]; other site 1118959004855 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1118959004856 dimer interface [polypeptide binding]; other site 1118959004857 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1118959004858 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1118959004859 nucleotide binding site [chemical binding]; other site 1118959004860 NEF interaction site [polypeptide binding]; other site 1118959004861 SBD interface [polypeptide binding]; other site 1118959004862 heat shock protein GrpE; Provisional; Region: PRK14140 1118959004863 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1118959004864 dimer interface [polypeptide binding]; other site 1118959004865 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1118959004866 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1118959004867 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1118959004868 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 1118959004869 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1118959004870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1118959004871 FeS/SAM binding site; other site 1118959004872 HemN C-terminal domain; Region: HemN_C; pfam06969 1118959004873 GTP-binding protein LepA; Provisional; Region: PRK05433 1118959004874 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1118959004875 G1 box; other site 1118959004876 putative GEF interaction site [polypeptide binding]; other site 1118959004877 GTP/Mg2+ binding site [chemical binding]; other site 1118959004878 Switch I region; other site 1118959004879 G2 box; other site 1118959004880 G3 box; other site 1118959004881 Switch II region; other site 1118959004882 G4 box; other site 1118959004883 G5 box; other site 1118959004884 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1118959004885 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1118959004886 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1118959004887 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1118959004888 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1118959004889 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1118959004890 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1118959004891 Competence protein; Region: Competence; pfam03772 1118959004892 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1118959004893 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1118959004894 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1118959004895 catalytic motif [active] 1118959004896 Zn binding site [ion binding]; other site 1118959004897 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1118959004898 Helix-hairpin-helix motif; Region: HHH; pfam00633 1118959004899 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1118959004900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959004901 S-adenosylmethionine binding site [chemical binding]; other site 1118959004902 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1118959004903 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1118959004904 Zn2+ binding site [ion binding]; other site 1118959004905 Mg2+ binding site [ion binding]; other site 1118959004906 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1118959004907 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1118959004908 active site 1118959004909 (T/H)XGH motif; other site 1118959004910 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1118959004911 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1118959004912 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1118959004913 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1118959004914 shikimate binding site; other site 1118959004915 NAD(P) binding site [chemical binding]; other site 1118959004916 GTPase YqeH; Provisional; Region: PRK13796 1118959004917 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1118959004918 GTP/Mg2+ binding site [chemical binding]; other site 1118959004919 G4 box; other site 1118959004920 G5 box; other site 1118959004921 G1 box; other site 1118959004922 Switch I region; other site 1118959004923 G2 box; other site 1118959004924 G3 box; other site 1118959004925 Switch II region; other site 1118959004926 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1118959004927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959004928 active site 1118959004929 motif I; other site 1118959004930 motif II; other site 1118959004931 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1118959004932 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1118959004933 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1118959004934 potential frameshift: common BLAST hit: gi|49486435|ref|YP_043656.1| enterotoxin 1118959004935 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1118959004936 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959004937 Fic family protein [Function unknown]; Region: COG3177 1118959004938 Fic/DOC family; Region: Fic; pfam02661 1118959004939 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1118959004940 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1118959004941 putative active site [active] 1118959004942 potential frameshift: common BLAST hit: gi|49486439|ref|YP_043660.1| biotin carboxylase 1118959004943 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1118959004944 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1118959004945 potential frameshift: common BLAST hit: gi|82751206|ref|YP_416947.1| acetyl-CoA biotin carboxylase 1118959004946 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1118959004947 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1118959004948 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1118959004949 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1118959004950 carboxyltransferase (CT) interaction site; other site 1118959004951 biotinylation site [posttranslational modification]; other site 1118959004952 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1118959004953 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1118959004954 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1118959004955 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1118959004956 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1118959004957 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1118959004958 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1118959004959 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1118959004960 Sugar specificity; other site 1118959004961 Pyrimidine base specificity; other site 1118959004962 ATP-binding site [chemical binding]; other site 1118959004963 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1118959004964 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1118959004965 Peptidase family U32; Region: Peptidase_U32; pfam01136 1118959004966 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1118959004967 Peptidase family U32; Region: Peptidase_U32; pfam01136 1118959004968 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1118959004969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959004970 S-adenosylmethionine binding site [chemical binding]; other site 1118959004971 hypothetical protein; Provisional; Region: PRK13678 1118959004972 potential frameshift: common BLAST hit: gi|87160105|ref|YP_494268.1| Holliday junction resolvase-like protein 1118959004973 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1118959004974 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 1118959004975 hypothetical protein; Provisional; Region: PRK05473 1118959004976 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1118959004977 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1118959004978 motif 1; other site 1118959004979 active site 1118959004980 motif 2; other site 1118959004981 motif 3; other site 1118959004982 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1118959004983 DHHA1 domain; Region: DHHA1; pfam02272 1118959004984 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1118959004985 AAA domain; Region: AAA_30; pfam13604 1118959004986 Family description; Region: UvrD_C_2; pfam13538 1118959004987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1118959004988 binding surface 1118959004989 TPR motif; other site 1118959004990 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1118959004991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1118959004992 binding surface 1118959004993 TPR motif; other site 1118959004994 TPR repeat; Region: TPR_11; pfam13414 1118959004995 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1118959004996 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1118959004997 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1118959004998 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1118959004999 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1118959005000 catalytic residue [active] 1118959005001 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1118959005002 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1118959005003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1118959005004 Predicted transcriptional regulator [Transcription]; Region: COG1959 1118959005005 Transcriptional regulator; Region: Rrf2; pfam02082 1118959005006 recombination factor protein RarA; Reviewed; Region: PRK13342 1118959005007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959005008 Walker A motif; other site 1118959005009 ATP binding site [chemical binding]; other site 1118959005010 Walker B motif; other site 1118959005011 arginine finger; other site 1118959005012 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1118959005013 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1118959005014 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1118959005015 putative ATP binding site [chemical binding]; other site 1118959005016 putative substrate interface [chemical binding]; other site 1118959005017 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1118959005018 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1118959005019 dimer interface [polypeptide binding]; other site 1118959005020 anticodon binding site; other site 1118959005021 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1118959005022 homodimer interface [polypeptide binding]; other site 1118959005023 motif 1; other site 1118959005024 active site 1118959005025 motif 2; other site 1118959005026 GAD domain; Region: GAD; pfam02938 1118959005027 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1118959005028 motif 3; other site 1118959005029 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1118959005030 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1118959005031 dimer interface [polypeptide binding]; other site 1118959005032 motif 1; other site 1118959005033 active site 1118959005034 motif 2; other site 1118959005035 motif 3; other site 1118959005036 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1118959005037 anticodon binding site; other site 1118959005038 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1118959005039 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1118959005040 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1118959005041 active site 1118959005042 metal binding site [ion binding]; metal-binding site 1118959005043 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1118959005044 putative active site [active] 1118959005045 dimerization interface [polypeptide binding]; other site 1118959005046 putative tRNAtyr binding site [nucleotide binding]; other site 1118959005047 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1118959005048 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1118959005049 Zn2+ binding site [ion binding]; other site 1118959005050 Mg2+ binding site [ion binding]; other site 1118959005051 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1118959005052 synthetase active site [active] 1118959005053 NTP binding site [chemical binding]; other site 1118959005054 metal binding site [ion binding]; metal-binding site 1118959005055 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1118959005056 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1118959005057 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1118959005058 active site 1118959005059 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1118959005060 DHH family; Region: DHH; pfam01368 1118959005061 DHHA1 domain; Region: DHHA1; pfam02272 1118959005062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1118959005063 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1118959005064 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1118959005065 Protein export membrane protein; Region: SecD_SecF; cl14618 1118959005066 Protein export membrane protein; Region: SecD_SecF; pfam02355 1118959005067 Preprotein translocase subunit; Region: YajC; pfam02699 1118959005068 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1118959005069 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1118959005070 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1118959005071 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1118959005072 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1118959005073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959005074 Walker A motif; other site 1118959005075 ATP binding site [chemical binding]; other site 1118959005076 Walker B motif; other site 1118959005077 arginine finger; other site 1118959005078 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1118959005079 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1118959005080 RuvA N terminal domain; Region: RuvA_N; pfam01330 1118959005081 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1118959005082 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 1118959005083 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1118959005084 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1118959005085 GTP1/OBG; Region: GTP1_OBG; pfam01018 1118959005086 Obg GTPase; Region: Obg; cd01898 1118959005087 G1 box; other site 1118959005088 GTP/Mg2+ binding site [chemical binding]; other site 1118959005089 Switch I region; other site 1118959005090 G2 box; other site 1118959005091 G3 box; other site 1118959005092 Switch II region; other site 1118959005093 G4 box; other site 1118959005094 G5 box; other site 1118959005095 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1118959005096 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1118959005097 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1118959005098 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1118959005099 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1118959005100 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1118959005101 potential frameshift: common BLAST hit: gi|269203274|ref|YP_003282543.1| rod shape-determining protein MreC 1118959005102 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1118959005103 rod shape-determining protein MreC; Region: MreC; pfam04085 1118959005104 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1118959005105 hypothetical protein; Reviewed; Region: PRK00024 1118959005106 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1118959005107 MPN+ (JAMM) motif; other site 1118959005108 Zinc-binding site [ion binding]; other site 1118959005109 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1118959005110 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1118959005111 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1118959005112 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1118959005113 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1118959005114 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1118959005115 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1118959005116 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1118959005117 active site 1118959005118 HIGH motif; other site 1118959005119 nucleotide binding site [chemical binding]; other site 1118959005120 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1118959005121 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1118959005122 active site 1118959005123 KMSKS motif; other site 1118959005124 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1118959005125 tRNA binding surface [nucleotide binding]; other site 1118959005126 anticodon binding site; other site 1118959005127 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1118959005128 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1118959005129 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1118959005130 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1118959005131 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1118959005132 inhibitor-cofactor binding pocket; inhibition site 1118959005133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959005134 catalytic residue [active] 1118959005135 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1118959005136 dimer interface [polypeptide binding]; other site 1118959005137 active site 1118959005138 Schiff base residues; other site 1118959005139 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1118959005140 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1118959005141 active site 1118959005142 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1118959005143 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1118959005144 domain interfaces; other site 1118959005145 active site 1118959005146 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 1118959005147 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1118959005148 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1118959005149 tRNA; other site 1118959005150 putative tRNA binding site [nucleotide binding]; other site 1118959005151 putative NADP binding site [chemical binding]; other site 1118959005152 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1118959005153 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1118959005154 G1 box; other site 1118959005155 GTP/Mg2+ binding site [chemical binding]; other site 1118959005156 Switch I region; other site 1118959005157 G2 box; other site 1118959005158 G3 box; other site 1118959005159 Switch II region; other site 1118959005160 G4 box; other site 1118959005161 G5 box; other site 1118959005162 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1118959005163 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1118959005164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959005165 Walker A motif; other site 1118959005166 ATP binding site [chemical binding]; other site 1118959005167 Walker B motif; other site 1118959005168 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1118959005169 trigger factor; Provisional; Region: tig; PRK01490 1118959005170 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1118959005171 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1118959005172 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1118959005173 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1118959005174 23S rRNA binding site [nucleotide binding]; other site 1118959005175 L21 binding site [polypeptide binding]; other site 1118959005176 L13 binding site [polypeptide binding]; other site 1118959005177 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1118959005178 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1118959005179 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1118959005180 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1118959005181 lysine transporter; Provisional; Region: PRK10836 1118959005182 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1118959005183 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1118959005184 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1118959005185 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1118959005186 active site 1118959005187 dimer interface [polypeptide binding]; other site 1118959005188 motif 1; other site 1118959005189 motif 2; other site 1118959005190 motif 3; other site 1118959005191 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1118959005192 anticodon binding site; other site 1118959005193 primosomal protein DnaI; Reviewed; Region: PRK08939 1118959005194 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1118959005195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959005196 Walker A motif; other site 1118959005197 ATP binding site [chemical binding]; other site 1118959005198 Walker B motif; other site 1118959005199 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1118959005200 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1118959005201 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1118959005202 ATP cone domain; Region: ATP-cone; pfam03477 1118959005203 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1118959005204 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1118959005205 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1118959005206 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1118959005207 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1118959005208 CoA-binding site [chemical binding]; other site 1118959005209 ATP-binding [chemical binding]; other site 1118959005210 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1118959005211 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1118959005212 DNA binding site [nucleotide binding] 1118959005213 catalytic residue [active] 1118959005214 H2TH interface [polypeptide binding]; other site 1118959005215 putative catalytic residues [active] 1118959005216 turnover-facilitating residue; other site 1118959005217 intercalation triad [nucleotide binding]; other site 1118959005218 8OG recognition residue [nucleotide binding]; other site 1118959005219 putative reading head residues; other site 1118959005220 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1118959005221 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1118959005222 DNA polymerase I; Provisional; Region: PRK05755 1118959005223 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1118959005224 active site 1118959005225 metal binding site 1 [ion binding]; metal-binding site 1118959005226 putative 5' ssDNA interaction site; other site 1118959005227 metal binding site 3; metal-binding site 1118959005228 metal binding site 2 [ion binding]; metal-binding site 1118959005229 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1118959005230 putative DNA binding site [nucleotide binding]; other site 1118959005231 putative metal binding site [ion binding]; other site 1118959005232 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1118959005233 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1118959005234 active site 1118959005235 DNA binding site [nucleotide binding] 1118959005236 catalytic site [active] 1118959005237 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1118959005238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1118959005239 dimer interface [polypeptide binding]; other site 1118959005240 phosphorylation site [posttranslational modification] 1118959005241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959005242 ATP binding site [chemical binding]; other site 1118959005243 Mg2+ binding site [ion binding]; other site 1118959005244 G-X-G motif; other site 1118959005245 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1118959005246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959005247 active site 1118959005248 phosphorylation site [posttranslational modification] 1118959005249 intermolecular recognition site; other site 1118959005250 dimerization interface [polypeptide binding]; other site 1118959005251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1118959005252 DNA binding site [nucleotide binding] 1118959005253 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1118959005254 isocitrate dehydrogenase; Validated; Region: PRK07362 1118959005255 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1118959005256 dimer interface [polypeptide binding]; other site 1118959005257 Citrate synthase; Region: Citrate_synt; pfam00285 1118959005258 active site 1118959005259 citrylCoA binding site [chemical binding]; other site 1118959005260 oxalacetate/citrate binding site [chemical binding]; other site 1118959005261 coenzyme A binding site [chemical binding]; other site 1118959005262 catalytic triad [active] 1118959005263 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1118959005264 pyruvate kinase; Provisional; Region: PRK06354 1118959005265 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1118959005266 domain interfaces; other site 1118959005267 active site 1118959005268 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1118959005269 6-phosphofructokinase; Provisional; Region: PRK03202 1118959005270 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1118959005271 active site 1118959005272 ADP/pyrophosphate binding site [chemical binding]; other site 1118959005273 dimerization interface [polypeptide binding]; other site 1118959005274 allosteric effector site; other site 1118959005275 fructose-1,6-bisphosphate binding site; other site 1118959005276 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1118959005277 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1118959005278 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1118959005279 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1118959005280 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1118959005281 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1118959005282 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1118959005283 putative NAD(P) binding site [chemical binding]; other site 1118959005284 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1118959005285 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1118959005286 active site 1118959005287 PHP Thumb interface [polypeptide binding]; other site 1118959005288 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1118959005289 generic binding surface I; other site 1118959005290 generic binding surface II; other site 1118959005291 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1118959005292 DHH family; Region: DHH; pfam01368 1118959005293 DHHA1 domain; Region: DHHA1; pfam02272 1118959005294 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1118959005295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1118959005296 DNA-binding site [nucleotide binding]; DNA binding site 1118959005297 DRTGG domain; Region: DRTGG; pfam07085 1118959005298 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1118959005299 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1118959005300 active site 2 [active] 1118959005301 active site 1 [active] 1118959005302 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1118959005303 Ligand Binding Site [chemical binding]; other site 1118959005304 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1118959005305 metal-dependent hydrolase; Provisional; Region: PRK00685 1118959005306 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1118959005307 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1118959005308 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1118959005309 active site 1118959005310 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1118959005311 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1118959005312 hexamer interface [polypeptide binding]; other site 1118959005313 ligand binding site [chemical binding]; other site 1118959005314 putative active site [active] 1118959005315 NAD(P) binding site [chemical binding]; other site 1118959005316 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1118959005317 Ligand Binding Site [chemical binding]; other site 1118959005318 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1118959005319 propionate/acetate kinase; Provisional; Region: PRK12379 1118959005320 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1118959005321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959005322 S-adenosylmethionine binding site [chemical binding]; other site 1118959005323 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1118959005324 dimer interface [polypeptide binding]; other site 1118959005325 catalytic triad [active] 1118959005326 peroxidatic and resolving cysteines [active] 1118959005327 hypothetical protein; Provisional; Region: PRK10621 1118959005328 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1118959005329 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1118959005330 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1118959005331 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1118959005332 Ligand Binding Site [chemical binding]; other site 1118959005333 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1118959005334 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1118959005335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1118959005336 catalytic residue [active] 1118959005337 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1118959005338 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1118959005339 GAF domain; Region: GAF_2; pfam13185 1118959005340 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1118959005341 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1118959005342 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1118959005343 RNA binding surface [nucleotide binding]; other site 1118959005344 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1118959005345 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1118959005346 active site 1118959005347 catalytic site [active] 1118959005348 OsmC-like protein; Region: OsmC; cl00767 1118959005349 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1118959005350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1118959005351 catalytic residue [active] 1118959005352 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1118959005353 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1118959005354 ligand binding site [chemical binding]; other site 1118959005355 NAD binding site [chemical binding]; other site 1118959005356 dimerization interface [polypeptide binding]; other site 1118959005357 catalytic site [active] 1118959005358 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1118959005359 putative L-serine binding site [chemical binding]; other site 1118959005360 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959005361 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1118959005362 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959005363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1118959005364 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1118959005365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959005366 motif II; other site 1118959005367 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1118959005368 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1118959005369 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1118959005370 active site turn [active] 1118959005371 phosphorylation site [posttranslational modification] 1118959005372 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1118959005373 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1118959005374 putative acyl-acceptor binding pocket; other site 1118959005375 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1118959005376 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1118959005377 protein binding site [polypeptide binding]; other site 1118959005378 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1118959005379 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1118959005380 active site 1118959005381 HIGH motif; other site 1118959005382 dimer interface [polypeptide binding]; other site 1118959005383 KMSKS motif; other site 1118959005384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1118959005385 RNA binding surface [nucleotide binding]; other site 1118959005386 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1118959005387 Transglycosylase; Region: Transgly; pfam00912 1118959005388 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 1118959005389 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1118959005390 NEAr Transporter domain; Region: NEAT; smart00725 1118959005391 NEAr Transporter domain; Region: NEAT; smart00725 1118959005392 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1118959005393 heme-binding site [chemical binding]; other site 1118959005394 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1118959005395 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1118959005396 Potassium binding sites [ion binding]; other site 1118959005397 Cesium cation binding sites [ion binding]; other site 1118959005398 acetyl-CoA synthetase; Provisional; Region: PRK04319 1118959005399 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1118959005400 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1118959005401 active site 1118959005402 acyl-activating enzyme (AAE) consensus motif; other site 1118959005403 putative CoA binding site [chemical binding]; other site 1118959005404 AMP binding site [chemical binding]; other site 1118959005405 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1118959005406 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1118959005407 active site 1118959005408 Zn binding site [ion binding]; other site 1118959005409 catabolite control protein A; Region: ccpA; TIGR01481 1118959005410 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1118959005411 DNA binding site [nucleotide binding] 1118959005412 domain linker motif; other site 1118959005413 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1118959005414 dimerization interface [polypeptide binding]; other site 1118959005415 effector binding site; other site 1118959005416 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1118959005417 Chorismate mutase type II; Region: CM_2; cl00693 1118959005418 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1118959005419 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1118959005420 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1118959005421 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1118959005422 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1118959005423 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1118959005424 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1118959005425 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1118959005426 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1118959005427 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1118959005428 putative tRNA-binding site [nucleotide binding]; other site 1118959005429 hypothetical protein; Provisional; Region: PRK13668 1118959005430 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1118959005431 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1118959005432 catalytic residues [active] 1118959005433 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1118959005434 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1118959005435 oligomer interface [polypeptide binding]; other site 1118959005436 active site 1118959005437 metal binding site [ion binding]; metal-binding site 1118959005438 Predicted small secreted protein [Function unknown]; Region: COG5584 1118959005439 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1118959005440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959005441 S-adenosylmethionine binding site [chemical binding]; other site 1118959005442 Phosphotransferase enzyme family; Region: APH; pfam01636 1118959005443 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1118959005444 active site 1118959005445 substrate binding site [chemical binding]; other site 1118959005446 ATP binding site [chemical binding]; other site 1118959005447 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1118959005448 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1118959005449 homodimer interface [polypeptide binding]; other site 1118959005450 substrate-cofactor binding pocket; other site 1118959005451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959005452 catalytic residue [active] 1118959005453 dipeptidase PepV; Reviewed; Region: PRK07318 1118959005454 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1118959005455 active site 1118959005456 metal binding site [ion binding]; metal-binding site 1118959005457 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1118959005458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1118959005459 RNA binding surface [nucleotide binding]; other site 1118959005460 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1118959005461 active site 1118959005462 uracil binding [chemical binding]; other site 1118959005463 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1118959005464 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1118959005465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1118959005466 HI0933-like protein; Region: HI0933_like; pfam03486 1118959005467 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1118959005468 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1118959005469 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005470 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005471 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005472 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005473 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005474 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005475 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005476 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005477 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005478 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005479 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005480 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005481 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005482 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005483 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1118959005484 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1118959005485 active site residue [active] 1118959005486 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1118959005487 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1118959005488 HIGH motif; other site 1118959005489 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1118959005490 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1118959005491 active site 1118959005492 KMSKS motif; other site 1118959005493 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1118959005494 tRNA binding surface [nucleotide binding]; other site 1118959005495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959005496 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1118959005497 putative substrate translocation pore; other site 1118959005498 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1118959005499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959005500 S-adenosylmethionine binding site [chemical binding]; other site 1118959005501 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959005502 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1118959005503 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1118959005504 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1118959005505 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1118959005506 homopentamer interface [polypeptide binding]; other site 1118959005507 active site 1118959005508 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1118959005509 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1118959005510 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1118959005511 dimerization interface [polypeptide binding]; other site 1118959005512 active site 1118959005513 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1118959005514 Lumazine binding domain; Region: Lum_binding; pfam00677 1118959005515 Lumazine binding domain; Region: Lum_binding; pfam00677 1118959005516 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1118959005517 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1118959005518 catalytic motif [active] 1118959005519 Zn binding site [ion binding]; other site 1118959005520 RibD C-terminal domain; Region: RibD_C; cl17279 1118959005521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1118959005522 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1118959005523 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1118959005524 arsenical pump membrane protein; Provisional; Region: PRK15445 1118959005525 transmembrane helices; other site 1118959005526 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1118959005527 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1118959005528 active site 1118959005529 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1118959005530 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1118959005531 CAAX protease self-immunity; Region: Abi; pfam02517 1118959005532 CAAX protease self-immunity; Region: Abi; pfam02517 1118959005533 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1118959005534 active site 1118959005535 intersubunit interactions; other site 1118959005536 catalytic residue [active] 1118959005537 camphor resistance protein CrcB; Provisional; Region: PRK14201 1118959005538 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1118959005539 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1118959005540 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1118959005541 active site 1118959005542 catalytic tetrad [active] 1118959005543 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1118959005544 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1118959005545 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1118959005546 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1118959005547 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1118959005548 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1118959005549 active site 1118959005550 substrate-binding site [chemical binding]; other site 1118959005551 metal-binding site [ion binding] 1118959005552 ATP binding site [chemical binding]; other site 1118959005553 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1118959005554 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1118959005555 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1118959005556 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1118959005557 nudix motif; other site 1118959005558 Haemolytic domain; Region: Haemolytic; pfam01809 1118959005559 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1118959005560 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1118959005561 metal binding site [ion binding]; metal-binding site 1118959005562 substrate binding pocket [chemical binding]; other site 1118959005563 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1118959005564 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1118959005565 acyl-activating enzyme (AAE) consensus motif; other site 1118959005566 putative AMP binding site [chemical binding]; other site 1118959005567 putative active site [active] 1118959005568 putative CoA binding site [chemical binding]; other site 1118959005569 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1118959005570 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1118959005571 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1118959005572 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1118959005573 Family description; Region: UvrD_C_2; pfam13538 1118959005574 potential frameshift: common BLAST hit: gi|49486992|ref|YP_044213.1| hyaluronate lyase precursor 2 1118959005575 Polysaccharide lyase family 8, super-sandwich domain; Region: Lyase_8; pfam02278 1118959005576 Polysaccharide lyase family 8, C-terminal beta-sandwich domain; Region: Lyase_8_C; pfam02884 1118959005577 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1118959005578 Peptidase family M23; Region: Peptidase_M23; pfam01551 1118959005579 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1118959005580 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1118959005581 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 1118959005582 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1118959005583 transposase/IS protein; Provisional; Region: PRK09183 1118959005584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959005585 Walker A motif; other site 1118959005586 ATP binding site [chemical binding]; other site 1118959005587 Walker B motif; other site 1118959005588 arginine finger; other site 1118959005589 Winged helix-turn helix; Region: HTH_29; pfam13551 1118959005590 Integrase core domain; Region: rve; pfam00665 1118959005591 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1118959005592 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1118959005593 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1118959005594 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1118959005595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1118959005596 ferrochelatase; Provisional; Region: PRK12435 1118959005597 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1118959005598 C-terminal domain interface [polypeptide binding]; other site 1118959005599 active site 1118959005600 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1118959005601 active site 1118959005602 N-terminal domain interface [polypeptide binding]; other site 1118959005603 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1118959005604 substrate binding site [chemical binding]; other site 1118959005605 active site 1118959005606 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1118959005607 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1118959005608 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1118959005609 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1118959005610 Walker A/P-loop; other site 1118959005611 ATP binding site [chemical binding]; other site 1118959005612 Q-loop/lid; other site 1118959005613 ABC transporter signature motif; other site 1118959005614 Walker B; other site 1118959005615 D-loop; other site 1118959005616 H-loop/switch region; other site 1118959005617 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1118959005618 HIT family signature motif; other site 1118959005619 catalytic residue [active] 1118959005620 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1118959005621 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1118959005622 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1118959005623 SurA N-terminal domain; Region: SurA_N_3; cl07813 1118959005624 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1118959005625 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1118959005626 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1118959005627 generic binding surface II; other site 1118959005628 generic binding surface I; other site 1118959005629 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1118959005630 Zn2+ binding site [ion binding]; other site 1118959005631 Mg2+ binding site [ion binding]; other site 1118959005632 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1118959005633 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1118959005634 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 1118959005635 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1118959005636 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1118959005637 active site 1118959005638 metal binding site [ion binding]; metal-binding site 1118959005639 DNA binding site [nucleotide binding] 1118959005640 hypothetical protein; Provisional; Region: PRK13676 1118959005641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1118959005642 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1118959005643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959005644 non-specific DNA binding site [nucleotide binding]; other site 1118959005645 salt bridge; other site 1118959005646 sequence-specific DNA binding site [nucleotide binding]; other site 1118959005647 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1118959005648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959005649 active site 1118959005650 phosphorylation site [posttranslational modification] 1118959005651 intermolecular recognition site; other site 1118959005652 dimerization interface [polypeptide binding]; other site 1118959005653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1118959005654 DNA binding residues [nucleotide binding] 1118959005655 dimerization interface [polypeptide binding]; other site 1118959005656 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1118959005657 GAF domain; Region: GAF_3; pfam13492 1118959005658 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1118959005659 Histidine kinase; Region: HisKA_3; pfam07730 1118959005660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959005661 ATP binding site [chemical binding]; other site 1118959005662 Mg2+ binding site [ion binding]; other site 1118959005663 G-X-G motif; other site 1118959005664 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1118959005665 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1118959005666 active site 1118959005667 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1118959005668 Class II fumarases; Region: Fumarase_classII; cd01362 1118959005669 active site 1118959005670 tetramer interface [polypeptide binding]; other site 1118959005671 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1118959005672 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1118959005673 active site 1118959005674 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1118959005675 epoxyqueuosine reductase; Region: TIGR00276 1118959005676 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1118959005677 HEAT repeats; Region: HEAT_2; pfam13646 1118959005678 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1118959005679 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1118959005680 Walker A/P-loop; other site 1118959005681 ATP binding site [chemical binding]; other site 1118959005682 Q-loop/lid; other site 1118959005683 ABC transporter signature motif; other site 1118959005684 Walker B; other site 1118959005685 D-loop; other site 1118959005686 H-loop/switch region; other site 1118959005687 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1118959005688 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1118959005689 substrate binding pocket [chemical binding]; other site 1118959005690 membrane-bound complex binding site; other site 1118959005691 hinge residues; other site 1118959005692 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1118959005693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959005694 dimer interface [polypeptide binding]; other site 1118959005695 conserved gate region; other site 1118959005696 putative PBP binding loops; other site 1118959005697 ABC-ATPase subunit interface; other site 1118959005698 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1118959005699 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1118959005700 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1118959005701 metal binding site 2 [ion binding]; metal-binding site 1118959005702 putative DNA binding helix; other site 1118959005703 metal binding site 1 [ion binding]; metal-binding site 1118959005704 dimer interface [polypeptide binding]; other site 1118959005705 structural Zn2+ binding site [ion binding]; other site 1118959005706 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1118959005707 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1118959005708 putative ligand binding site [chemical binding]; other site 1118959005709 NAD binding site [chemical binding]; other site 1118959005710 catalytic site [active] 1118959005711 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1118959005712 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1118959005713 catalytic triad [active] 1118959005714 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1118959005715 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1118959005716 inhibitor-cofactor binding pocket; inhibition site 1118959005717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959005718 catalytic residue [active] 1118959005719 Predicted membrane protein [Function unknown]; Region: COG4129 1118959005720 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1118959005721 potential frameshift: common BLAST hit: gi|269203503|ref|YP_003282772.1| toxin exporting ABC transporter, permease 1118959005722 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1118959005723 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1118959005724 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1118959005725 Walker A/P-loop; other site 1118959005726 ATP binding site [chemical binding]; other site 1118959005727 Q-loop/lid; other site 1118959005728 ABC transporter signature motif; other site 1118959005729 Walker B; other site 1118959005730 D-loop; other site 1118959005731 H-loop/switch region; other site 1118959005732 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1118959005733 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1118959005734 hypothetical protein; Provisional; Region: PRK13662 1118959005735 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1118959005736 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1118959005737 minor groove reading motif; other site 1118959005738 helix-hairpin-helix signature motif; other site 1118959005739 substrate binding pocket [chemical binding]; other site 1118959005740 active site 1118959005741 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1118959005742 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1118959005743 DNA binding and oxoG recognition site [nucleotide binding] 1118959005744 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1118959005745 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1118959005746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959005747 Walker A/P-loop; other site 1118959005748 ATP binding site [chemical binding]; other site 1118959005749 Q-loop/lid; other site 1118959005750 ABC transporter signature motif; other site 1118959005751 Walker B; other site 1118959005752 H-loop/switch region; other site 1118959005753 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1118959005754 recombination regulator RecX; Provisional; Region: recX; PRK14135 1118959005755 glycosyltransferase; Provisional; Region: PRK13481 1118959005756 Transglycosylase; Region: Transgly; pfam00912 1118959005757 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1118959005758 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1118959005759 proposed catalytic triad [active] 1118959005760 conserved cys residue [active] 1118959005761 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1118959005762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1118959005763 FeS/SAM binding site; other site 1118959005764 YfkB-like domain; Region: YfkB; pfam08756 1118959005765 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1118959005766 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1118959005767 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1118959005768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 1118959005769 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1118959005770 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1118959005771 active site 1118959005772 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1118959005773 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1118959005774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959005775 active site 1118959005776 phosphorylation site [posttranslational modification] 1118959005777 intermolecular recognition site; other site 1118959005778 dimerization interface [polypeptide binding]; other site 1118959005779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1118959005780 DNA binding residues [nucleotide binding] 1118959005781 dimerization interface [polypeptide binding]; other site 1118959005782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1118959005783 Histidine kinase; Region: HisKA_3; pfam07730 1118959005784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959005785 ATP binding site [chemical binding]; other site 1118959005786 Mg2+ binding site [ion binding]; other site 1118959005787 G-X-G motif; other site 1118959005788 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1118959005789 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1118959005790 active site 1118959005791 Predicted membrane protein [Function unknown]; Region: COG4129 1118959005792 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1118959005793 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1118959005794 catalytic triad [active] 1118959005795 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1118959005796 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1118959005797 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1118959005798 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1118959005799 Ferritin-like domain; Region: Ferritin; pfam00210 1118959005800 ferroxidase diiron center [ion binding]; other site 1118959005801 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1118959005802 active site 1118959005803 catalytic site [active] 1118959005804 substrate binding site [chemical binding]; other site 1118959005805 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1118959005806 active site 1118959005807 DNA polymerase IV; Validated; Region: PRK02406 1118959005808 DNA binding site [nucleotide binding] 1118959005809 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1118959005810 TRAM domain; Region: TRAM; cl01282 1118959005811 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1118959005812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959005813 S-adenosylmethionine binding site [chemical binding]; other site 1118959005814 putative lipid kinase; Reviewed; Region: PRK13337 1118959005815 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1118959005816 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1118959005817 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1118959005818 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1118959005819 GatB domain; Region: GatB_Yqey; pfam02637 1118959005820 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1118959005821 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1118959005822 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1118959005823 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1118959005824 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1118959005825 Na binding site [ion binding]; other site 1118959005826 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1118959005827 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1118959005828 putative dimer interface [polypeptide binding]; other site 1118959005829 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1118959005830 putative dimer interface [polypeptide binding]; other site 1118959005831 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1118959005832 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1118959005833 nucleotide binding pocket [chemical binding]; other site 1118959005834 K-X-D-G motif; other site 1118959005835 catalytic site [active] 1118959005836 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1118959005837 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1118959005838 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1118959005839 Dimer interface [polypeptide binding]; other site 1118959005840 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1118959005841 Part of AAA domain; Region: AAA_19; pfam13245 1118959005842 Family description; Region: UvrD_C_2; pfam13538 1118959005843 PcrB family; Region: PcrB; pfam01884 1118959005844 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1118959005845 substrate binding site [chemical binding]; other site 1118959005846 putative active site [active] 1118959005847 dimer interface [polypeptide binding]; other site 1118959005848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1118959005849 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1118959005850 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1118959005851 tetramer interface [polypeptide binding]; other site 1118959005852 active site 1118959005853 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1118959005854 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1118959005855 NETI protein; Region: NETI; pfam14044 1118959005856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1118959005857 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1118959005858 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1118959005859 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1118959005860 homodimer interface [polypeptide binding]; other site 1118959005861 NAD binding pocket [chemical binding]; other site 1118959005862 ATP binding pocket [chemical binding]; other site 1118959005863 Mg binding site [ion binding]; other site 1118959005864 active-site loop [active] 1118959005865 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1118959005866 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1118959005867 active site 1118959005868 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1118959005869 active site 1118959005870 dimer interface [polypeptide binding]; other site 1118959005871 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1118959005872 Prephenate dehydratase; Region: PDT; pfam00800 1118959005873 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1118959005874 putative L-Phe binding site [chemical binding]; other site 1118959005875 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1118959005876 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1118959005877 transmembrane helices; other site 1118959005878 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1118959005879 Isochorismatase family; Region: Isochorismatase; pfam00857 1118959005880 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1118959005881 catalytic triad [active] 1118959005882 conserved cis-peptide bond; other site 1118959005883 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1118959005884 DHH family; Region: DHH; pfam01368 1118959005885 DHHA2 domain; Region: DHHA2; pfam02833 1118959005886 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1118959005887 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1118959005888 NAD(P) binding site [chemical binding]; other site 1118959005889 catalytic residues [active] 1118959005890 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1118959005891 YolD-like protein; Region: YolD; pfam08863 1118959005892 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 1118959005893 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1118959005894 active site 1118959005895 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1118959005896 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1118959005897 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1118959005898 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1118959005899 Bacterial PH domain; Region: DUF304; cl01348 1118959005900 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1118959005901 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1118959005902 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1118959005903 Walker A/P-loop; other site 1118959005904 ATP binding site [chemical binding]; other site 1118959005905 Q-loop/lid; other site 1118959005906 ABC transporter signature motif; other site 1118959005907 Walker B; other site 1118959005908 D-loop; other site 1118959005909 H-loop/switch region; other site 1118959005910 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1118959005911 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1118959005912 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1118959005913 Walker A/P-loop; other site 1118959005914 ATP binding site [chemical binding]; other site 1118959005915 Q-loop/lid; other site 1118959005916 ABC transporter signature motif; other site 1118959005917 Walker B; other site 1118959005918 D-loop; other site 1118959005919 H-loop/switch region; other site 1118959005920 Predicted transcriptional regulators [Transcription]; Region: COG1725 1118959005921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1118959005922 DNA-binding site [nucleotide binding]; DNA binding site 1118959005923 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1118959005924 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1118959005925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959005926 homodimer interface [polypeptide binding]; other site 1118959005927 catalytic residue [active] 1118959005928 MAP domain; Region: MAP; pfam03642 1118959005929 MAP domain; Region: MAP; pfam03642 1118959005930 MAP domain; Region: MAP; pfam03642 1118959005931 MAP domain; Region: MAP; pfam03642 1118959005932 MAP domain; Region: MAP; pfam03642 1118959005933 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1118959005934 putative catalytic site [active] 1118959005935 metal binding site A [ion binding]; metal-binding site 1118959005936 phosphate binding site [ion binding]; other site 1118959005937 metal binding site C [ion binding]; metal-binding site 1118959005938 metal binding site B [ion binding]; metal-binding site 1118959005939 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1118959005940 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1118959005941 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1118959005942 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1118959005943 metal binding site [ion binding]; metal-binding site 1118959005944 dimer interface [polypeptide binding]; other site 1118959005945 Cation transport protein; Region: TrkH; cl17365 1118959005946 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1118959005947 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1118959005948 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1118959005949 ring oligomerisation interface [polypeptide binding]; other site 1118959005950 ATP/Mg binding site [chemical binding]; other site 1118959005951 stacking interactions; other site 1118959005952 hinge regions; other site 1118959005953 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1118959005954 oligomerisation interface [polypeptide binding]; other site 1118959005955 mobile loop; other site 1118959005956 roof hairpin; other site 1118959005957 CAAX protease self-immunity; Region: Abi; pfam02517 1118959005958 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1118959005959 dimer interface [polypeptide binding]; other site 1118959005960 FMN binding site [chemical binding]; other site 1118959005961 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1118959005962 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1118959005963 putative active site [active] 1118959005964 catalytic triad [active] 1118959005965 putative dimer interface [polypeptide binding]; other site 1118959005966 delta-hemolysin; Provisional; Region: PRK14752 1118959005967 Accessory gene regulator B; Region: AgrB; smart00793 1118959005968 Staphylococcal AgrD protein; Region: AgrD; smart00794 1118959005969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959005970 Mg2+ binding site [ion binding]; other site 1118959005971 G-X-G motif; other site 1118959005972 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1118959005973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959005974 active site 1118959005975 phosphorylation site [posttranslational modification] 1118959005976 intermolecular recognition site; other site 1118959005977 dimerization interface [polypeptide binding]; other site 1118959005978 LytTr DNA-binding domain; Region: LytTR; pfam04397 1118959005979 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1118959005980 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1118959005981 putative substrate binding site [chemical binding]; other site 1118959005982 putative ATP binding site [chemical binding]; other site 1118959005983 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1118959005984 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1118959005985 substrate binding [chemical binding]; other site 1118959005986 active site 1118959005987 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1118959005988 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1118959005989 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1118959005990 DNA binding site [nucleotide binding] 1118959005991 domain linker motif; other site 1118959005992 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1118959005993 dimerization interface [polypeptide binding]; other site 1118959005994 ligand binding site [chemical binding]; other site 1118959005995 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1118959005996 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1118959005997 CPxP motif; other site 1118959005998 Predicted transporter component [General function prediction only]; Region: COG2391 1118959005999 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1118959006000 Sulphur transport; Region: Sulf_transp; pfam04143 1118959006001 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1118959006002 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1118959006003 CoA binding domain; Region: CoA_binding; pfam02629 1118959006004 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1118959006005 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1118959006006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1118959006007 ABC transporter; Region: ABC_tran_2; pfam12848 1118959006008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1118959006009 truncated transposase, putative 1118959006010 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 1118959006011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959006012 Walker A/P-loop; other site 1118959006013 ATP binding site [chemical binding]; other site 1118959006014 Q-loop/lid; other site 1118959006015 ABC transporter signature motif; other site 1118959006016 Walker B; other site 1118959006017 D-loop; other site 1118959006018 H-loop/switch region; other site 1118959006019 UGMP family protein; Validated; Region: PRK09604 1118959006020 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1118959006021 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1118959006022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959006023 Coenzyme A binding pocket [chemical binding]; other site 1118959006024 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1118959006025 Glycoprotease family; Region: Peptidase_M22; pfam00814 1118959006026 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1118959006027 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1118959006028 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1118959006029 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1118959006030 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1118959006031 PYR/PP interface [polypeptide binding]; other site 1118959006032 dimer interface [polypeptide binding]; other site 1118959006033 TPP binding site [chemical binding]; other site 1118959006034 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1118959006035 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1118959006036 TPP-binding site [chemical binding]; other site 1118959006037 dimer interface [polypeptide binding]; other site 1118959006038 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1118959006039 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1118959006040 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1118959006041 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1118959006042 2-isopropylmalate synthase; Validated; Region: PRK00915 1118959006043 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1118959006044 active site 1118959006045 catalytic residues [active] 1118959006046 metal binding site [ion binding]; metal-binding site 1118959006047 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1118959006048 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1118959006049 tartrate dehydrogenase; Region: TTC; TIGR02089 1118959006050 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1118959006051 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1118959006052 substrate binding site [chemical binding]; other site 1118959006053 ligand binding site [chemical binding]; other site 1118959006054 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1118959006055 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1118959006056 substrate binding site [chemical binding]; other site 1118959006057 threonine dehydratase; Validated; Region: PRK08639 1118959006058 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1118959006059 tetramer interface [polypeptide binding]; other site 1118959006060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959006061 catalytic residue [active] 1118959006062 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1118959006063 putative Ile/Val binding site [chemical binding]; other site 1118959006064 hypothetical protein; Provisional; Region: PRK04351 1118959006065 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1118959006066 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1118959006067 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1118959006068 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1118959006069 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1118959006070 RNA binding site [nucleotide binding]; other site 1118959006071 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1118959006072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1118959006073 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1118959006074 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1118959006075 DNA binding residues [nucleotide binding] 1118959006076 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1118959006077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959006078 ATP binding site [chemical binding]; other site 1118959006079 Mg2+ binding site [ion binding]; other site 1118959006080 G-X-G motif; other site 1118959006081 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1118959006082 anti sigma factor interaction site; other site 1118959006083 regulatory phosphorylation site [posttranslational modification]; other site 1118959006084 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1118959006085 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1118959006086 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1118959006087 PemK-like protein; Region: PemK; pfam02452 1118959006088 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1118959006089 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1118959006090 active site 1118959006091 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1118959006092 dimer interface [polypeptide binding]; other site 1118959006093 substrate binding site [chemical binding]; other site 1118959006094 catalytic residues [active] 1118959006095 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1118959006096 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1118959006097 Predicted membrane protein [Function unknown]; Region: COG3428 1118959006098 Bacterial PH domain; Region: DUF304; pfam03703 1118959006099 Bacterial PH domain; Region: DUF304; pfam03703 1118959006100 Bacterial PH domain; Region: DUF304; cl01348 1118959006101 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1118959006102 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 1118959006103 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1118959006104 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1118959006105 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1118959006106 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1118959006107 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1118959006108 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1118959006109 Ligand Binding Site [chemical binding]; other site 1118959006110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1118959006111 dimer interface [polypeptide binding]; other site 1118959006112 phosphorylation site [posttranslational modification] 1118959006113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959006114 ATP binding site [chemical binding]; other site 1118959006115 Mg2+ binding site [ion binding]; other site 1118959006116 G-X-G motif; other site 1118959006117 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1118959006118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959006119 active site 1118959006120 phosphorylation site [posttranslational modification] 1118959006121 intermolecular recognition site; other site 1118959006122 dimerization interface [polypeptide binding]; other site 1118959006123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1118959006124 DNA binding site [nucleotide binding] 1118959006125 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1118959006126 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1118959006127 ATP binding site [chemical binding]; other site 1118959006128 Mg++ binding site [ion binding]; other site 1118959006129 motif III; other site 1118959006130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1118959006131 nucleotide binding region [chemical binding]; other site 1118959006132 ATP-binding site [chemical binding]; other site 1118959006133 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1118959006134 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1118959006135 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1118959006136 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1118959006137 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1118959006138 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1118959006139 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1118959006140 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1118959006141 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1118959006142 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1118959006143 putative homodimer interface [polypeptide binding]; other site 1118959006144 putative homotetramer interface [polypeptide binding]; other site 1118959006145 allosteric switch controlling residues; other site 1118959006146 putative metal binding site [ion binding]; other site 1118959006147 putative homodimer-homodimer interface [polypeptide binding]; other site 1118959006148 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1118959006149 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1118959006150 putative active site [active] 1118959006151 catalytic site [active] 1118959006152 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1118959006153 putative active site [active] 1118959006154 catalytic site [active] 1118959006155 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1118959006156 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1118959006157 Zn2+ binding site [ion binding]; other site 1118959006158 Mg2+ binding site [ion binding]; other site 1118959006159 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1118959006160 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1118959006161 thiamine phosphate binding site [chemical binding]; other site 1118959006162 active site 1118959006163 pyrophosphate binding site [ion binding]; other site 1118959006164 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1118959006165 substrate binding site [chemical binding]; other site 1118959006166 multimerization interface [polypeptide binding]; other site 1118959006167 ATP binding site [chemical binding]; other site 1118959006168 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1118959006169 dimer interface [polypeptide binding]; other site 1118959006170 substrate binding site [chemical binding]; other site 1118959006171 ATP binding site [chemical binding]; other site 1118959006172 thiaminase II; Region: salvage_TenA; TIGR04306 1118959006173 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1118959006174 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1118959006175 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1118959006176 dimer interface [polypeptide binding]; other site 1118959006177 ssDNA binding site [nucleotide binding]; other site 1118959006178 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1118959006179 truncated IS232 IstB protein homolog 1118959006180 Winged helix-turn helix; Region: HTH_29; pfam13551 1118959006181 Integrase core domain; Region: rve; pfam00665 1118959006182 YwpF-like protein; Region: YwpF; pfam14183 1118959006183 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1118959006184 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1118959006185 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1118959006186 hinge; other site 1118959006187 active site 1118959006188 Predicted membrane protein [Function unknown]; Region: COG4836 1118959006189 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 1118959006190 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1118959006191 gamma subunit interface [polypeptide binding]; other site 1118959006192 epsilon subunit interface [polypeptide binding]; other site 1118959006193 LBP interface [polypeptide binding]; other site 1118959006194 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1118959006195 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1118959006196 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1118959006197 alpha subunit interaction interface [polypeptide binding]; other site 1118959006198 Walker A motif; other site 1118959006199 ATP binding site [chemical binding]; other site 1118959006200 Walker B motif; other site 1118959006201 inhibitor binding site; inhibition site 1118959006202 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1118959006203 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1118959006204 core domain interface [polypeptide binding]; other site 1118959006205 delta subunit interface [polypeptide binding]; other site 1118959006206 epsilon subunit interface [polypeptide binding]; other site 1118959006207 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1118959006208 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1118959006209 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1118959006210 beta subunit interaction interface [polypeptide binding]; other site 1118959006211 Walker A motif; other site 1118959006212 ATP binding site [chemical binding]; other site 1118959006213 Walker B motif; other site 1118959006214 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1118959006215 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1118959006216 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1118959006217 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1118959006218 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1118959006219 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1118959006220 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1118959006221 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1118959006222 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1118959006223 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1118959006224 active site 1118959006225 homodimer interface [polypeptide binding]; other site 1118959006226 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1118959006227 active site 1118959006228 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1118959006229 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1118959006230 dimer interface [polypeptide binding]; other site 1118959006231 active site 1118959006232 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1118959006233 folate binding site [chemical binding]; other site 1118959006234 hypothetical protein; Provisional; Region: PRK13690 1118959006235 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1118959006236 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1118959006237 active site 1118959006238 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1118959006239 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1118959006240 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1118959006241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959006242 S-adenosylmethionine binding site [chemical binding]; other site 1118959006243 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1118959006244 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1118959006245 RF-1 domain; Region: RF-1; pfam00472 1118959006246 thymidine kinase; Provisional; Region: PRK04296 1118959006247 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1118959006248 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1118959006249 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1118959006250 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1118959006251 RNA binding site [nucleotide binding]; other site 1118959006252 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1118959006253 multimer interface [polypeptide binding]; other site 1118959006254 Walker A motif; other site 1118959006255 ATP binding site [chemical binding]; other site 1118959006256 Walker B motif; other site 1118959006257 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1118959006258 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1118959006259 NAD binding site [chemical binding]; other site 1118959006260 catalytic residues [active] 1118959006261 Predicted transcriptional regulators [Transcription]; Region: COG1733 1118959006262 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1118959006263 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1118959006264 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1118959006265 hinge; other site 1118959006266 active site 1118959006267 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1118959006268 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1118959006269 intersubunit interface [polypeptide binding]; other site 1118959006270 active site 1118959006271 zinc binding site [ion binding]; other site 1118959006272 Na+ binding site [ion binding]; other site 1118959006273 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1118959006274 CTP synthetase; Validated; Region: pyrG; PRK05380 1118959006275 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1118959006276 Catalytic site [active] 1118959006277 active site 1118959006278 UTP binding site [chemical binding]; other site 1118959006279 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1118959006280 active site 1118959006281 putative oxyanion hole; other site 1118959006282 catalytic triad [active] 1118959006283 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1118959006284 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1118959006285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959006286 Coenzyme A binding pocket [chemical binding]; other site 1118959006287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1118959006288 Coenzyme A binding pocket [chemical binding]; other site 1118959006289 pantothenate kinase; Provisional; Region: PRK13317 1118959006290 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1118959006291 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1118959006292 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1118959006293 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1118959006294 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1118959006295 metal binding site [ion binding]; metal-binding site 1118959006296 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1118959006297 Predicted membrane protein [Function unknown]; Region: COG4270 1118959006298 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1118959006299 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 1118959006300 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1118959006301 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1118959006302 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1118959006303 intersubunit interface [polypeptide binding]; other site 1118959006304 active site 1118959006305 catalytic residue [active] 1118959006306 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1118959006307 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1118959006308 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1118959006309 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1118959006310 dimerization interface [polypeptide binding]; other site 1118959006311 DPS ferroxidase diiron center [ion binding]; other site 1118959006312 ion pore; other site 1118959006313 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1118959006314 EVE domain; Region: EVE; cl00728 1118959006315 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1118959006316 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1118959006317 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1118959006318 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1118959006319 NAD(P) binding site [chemical binding]; other site 1118959006320 putative active site [active] 1118959006321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1118959006322 dimerization interface [polypeptide binding]; other site 1118959006323 putative DNA binding site [nucleotide binding]; other site 1118959006324 putative Zn2+ binding site [ion binding]; other site 1118959006325 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1118959006326 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1118959006327 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1118959006328 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1118959006329 catalytic residues [active] 1118959006330 potential frameshift: common BLAST hit: gi|87161744|ref|YP_494747.1| SAP domain-containing protein 1118959006331 SAP domain; Region: SAP; pfam02037 1118959006332 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1118959006333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959006334 active site 1118959006335 motif I; other site 1118959006336 motif II; other site 1118959006337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959006338 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1118959006339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959006340 Walker A/P-loop; other site 1118959006341 ATP binding site [chemical binding]; other site 1118959006342 Q-loop/lid; other site 1118959006343 ABC transporter signature motif; other site 1118959006344 Walker B; other site 1118959006345 D-loop; other site 1118959006346 H-loop/switch region; other site 1118959006347 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1118959006348 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1118959006349 glutaminase active site [active] 1118959006350 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1118959006351 dimer interface [polypeptide binding]; other site 1118959006352 active site 1118959006353 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1118959006354 dimer interface [polypeptide binding]; other site 1118959006355 active site 1118959006356 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1118959006357 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1118959006358 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1118959006359 active site 1118959006360 P-loop; other site 1118959006361 phosphorylation site [posttranslational modification] 1118959006362 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1118959006363 HTH domain; Region: HTH_11; pfam08279 1118959006364 Mga helix-turn-helix domain; Region: Mga; pfam05043 1118959006365 PRD domain; Region: PRD; pfam00874 1118959006366 PRD domain; Region: PRD; pfam00874 1118959006367 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1118959006368 active site 1118959006369 P-loop; other site 1118959006370 phosphorylation site [posttranslational modification] 1118959006371 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1118959006372 active site 1118959006373 phosphorylation site [posttranslational modification] 1118959006374 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1118959006375 active site 1118959006376 phosphorylation site [posttranslational modification] 1118959006377 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1118959006378 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1118959006379 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1118959006380 FmtB (Mrp) protein involved in methicillinresistance and cell wall biosynthesis; truncated 1118959006381 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1118959006382 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1118959006383 active site 1118959006384 substrate binding site [chemical binding]; other site 1118959006385 metal binding site [ion binding]; metal-binding site 1118959006386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1118959006387 YbbR-like protein; Region: YbbR; pfam07949 1118959006388 YbbR-like protein; Region: YbbR; pfam07949 1118959006389 TIGR00159 family protein; Region: TIGR00159 1118959006390 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1118959006391 Arginase family; Region: Arginase; cd09989 1118959006392 active site 1118959006393 Mn binding site [ion binding]; other site 1118959006394 oligomer interface [polypeptide binding]; other site 1118959006395 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1118959006396 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1118959006397 Walker A motif; other site 1118959006398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959006399 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1118959006400 putative substrate translocation pore; other site 1118959006401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959006402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1118959006403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959006404 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1118959006405 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1118959006406 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1118959006407 substrate binding site; other site 1118959006408 dimerization interface; other site 1118959006409 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1118959006410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1118959006411 Nucleoside recognition; Region: Gate; pfam07670 1118959006412 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1118959006413 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959006414 ABC-ATPase subunit interface; other site 1118959006415 dimer interface [polypeptide binding]; other site 1118959006416 putative PBP binding regions; other site 1118959006417 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1118959006418 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1118959006419 ABC-ATPase subunit interface; other site 1118959006420 dimer interface [polypeptide binding]; other site 1118959006421 putative PBP binding regions; other site 1118959006422 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1118959006423 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1118959006424 siderophore binding site; other site 1118959006425 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1118959006426 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1118959006427 dimer interface [polypeptide binding]; other site 1118959006428 active site 1118959006429 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1118959006430 substrate binding site [chemical binding]; other site 1118959006431 catalytic residue [active] 1118959006432 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1118959006433 IucA / IucC family; Region: IucA_IucC; pfam04183 1118959006434 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1118959006435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959006436 putative substrate translocation pore; other site 1118959006437 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1118959006438 IucA / IucC family; Region: IucA_IucC; pfam04183 1118959006439 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1118959006440 Asp23 family; Region: Asp23; pfam03780 1118959006441 Small integral membrane protein [Function unknown]; Region: COG5547 1118959006442 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1118959006443 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1118959006444 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1118959006445 putative NAD(P) binding site [chemical binding]; other site 1118959006446 dimer interface [polypeptide binding]; other site 1118959006447 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1118959006448 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1118959006449 NAD(P) binding site [chemical binding]; other site 1118959006450 substrate binding site [chemical binding]; other site 1118959006451 dimer interface [polypeptide binding]; other site 1118959006452 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1118959006453 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1118959006454 beta-galactosidase; Region: BGL; TIGR03356 1118959006455 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1118959006456 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1118959006457 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1118959006458 active site 1118959006459 P-loop; other site 1118959006460 phosphorylation site [posttranslational modification] 1118959006461 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1118959006462 methionine cluster; other site 1118959006463 active site 1118959006464 phosphorylation site [posttranslational modification] 1118959006465 metal binding site [ion binding]; metal-binding site 1118959006466 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1118959006467 potential frameshift: common BLAST hit: gi|87161951|ref|YP_494789.1| tagatose-6-phosphate kinase 1118959006468 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1118959006469 ATP binding site [chemical binding]; other site 1118959006470 substrate binding site [chemical binding]; other site 1118959006471 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1118959006472 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1118959006473 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1118959006474 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1118959006475 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1118959006476 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1118959006477 NAD-dependent deacetylase; Provisional; Region: PRK00481 1118959006478 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1118959006479 NAD+ binding site [chemical binding]; other site 1118959006480 substrate binding site [chemical binding]; other site 1118959006481 putative Zn binding site [ion binding]; other site 1118959006482 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1118959006483 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1118959006484 active site 1118959006485 catalytic tetrad [active] 1118959006486 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1118959006487 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1118959006488 DNA binding residues [nucleotide binding] 1118959006489 putative dimer interface [polypeptide binding]; other site 1118959006490 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1118959006491 substrate binding site [chemical binding]; other site 1118959006492 catalytic residues [active] 1118959006493 Predicted transcriptional regulator [Transcription]; Region: COG2378 1118959006494 HTH domain; Region: HTH_11; pfam08279 1118959006495 WYL domain; Region: WYL; pfam13280 1118959006496 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1118959006497 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1118959006498 conserved cys residue [active] 1118959006499 Truncated cell surface protein map-w 1118959006500 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1118959006501 acetolactate synthase; Reviewed; Region: PRK08617 1118959006502 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1118959006503 PYR/PP interface [polypeptide binding]; other site 1118959006504 dimer interface [polypeptide binding]; other site 1118959006505 TPP binding site [chemical binding]; other site 1118959006506 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1118959006507 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1118959006508 TPP-binding site [chemical binding]; other site 1118959006509 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1118959006510 Divergent AAA domain; Region: AAA_4; pfam04326 1118959006511 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1118959006512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1118959006513 putative DNA binding site [nucleotide binding]; other site 1118959006514 putative Zn2+ binding site [ion binding]; other site 1118959006515 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1118959006516 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1118959006517 23S rRNA interface [nucleotide binding]; other site 1118959006518 L3 interface [polypeptide binding]; other site 1118959006519 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1118959006520 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1118959006521 dimerization interface 3.5A [polypeptide binding]; other site 1118959006522 active site 1118959006523 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1118959006524 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1118959006525 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1118959006526 Walker A/P-loop; other site 1118959006527 ATP binding site [chemical binding]; other site 1118959006528 Q-loop/lid; other site 1118959006529 ABC transporter signature motif; other site 1118959006530 Walker B; other site 1118959006531 D-loop; other site 1118959006532 H-loop/switch region; other site 1118959006533 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1118959006534 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1118959006535 Walker A/P-loop; other site 1118959006536 ATP binding site [chemical binding]; other site 1118959006537 Q-loop/lid; other site 1118959006538 ABC transporter signature motif; other site 1118959006539 Walker B; other site 1118959006540 D-loop; other site 1118959006541 H-loop/switch region; other site 1118959006542 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1118959006543 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1118959006544 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1118959006545 alphaNTD homodimer interface [polypeptide binding]; other site 1118959006546 alphaNTD - beta interaction site [polypeptide binding]; other site 1118959006547 alphaNTD - beta' interaction site [polypeptide binding]; other site 1118959006548 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1118959006549 30S ribosomal protein S11; Validated; Region: PRK05309 1118959006550 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1118959006551 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1118959006552 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1118959006553 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1118959006554 rRNA binding site [nucleotide binding]; other site 1118959006555 predicted 30S ribosome binding site; other site 1118959006556 adenylate kinase; Reviewed; Region: adk; PRK00279 1118959006557 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1118959006558 AMP-binding site [chemical binding]; other site 1118959006559 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1118959006560 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1118959006561 SecY translocase; Region: SecY; pfam00344 1118959006562 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1118959006563 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1118959006564 23S rRNA binding site [nucleotide binding]; other site 1118959006565 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1118959006566 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1118959006567 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1118959006568 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1118959006569 5S rRNA interface [nucleotide binding]; other site 1118959006570 L27 interface [polypeptide binding]; other site 1118959006571 23S rRNA interface [nucleotide binding]; other site 1118959006572 L5 interface [polypeptide binding]; other site 1118959006573 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1118959006574 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1118959006575 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1118959006576 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1118959006577 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1118959006578 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1118959006579 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1118959006580 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1118959006581 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1118959006582 RNA binding site [nucleotide binding]; other site 1118959006583 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1118959006584 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1118959006585 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1118959006586 23S rRNA interface [nucleotide binding]; other site 1118959006587 putative translocon interaction site; other site 1118959006588 signal recognition particle (SRP54) interaction site; other site 1118959006589 L23 interface [polypeptide binding]; other site 1118959006590 trigger factor interaction site; other site 1118959006591 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1118959006592 23S rRNA interface [nucleotide binding]; other site 1118959006593 5S rRNA interface [nucleotide binding]; other site 1118959006594 putative antibiotic binding site [chemical binding]; other site 1118959006595 L25 interface [polypeptide binding]; other site 1118959006596 L27 interface [polypeptide binding]; other site 1118959006597 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1118959006598 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1118959006599 G-X-X-G motif; other site 1118959006600 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1118959006601 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1118959006602 putative translocon binding site; other site 1118959006603 protein-rRNA interface [nucleotide binding]; other site 1118959006604 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1118959006605 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1118959006606 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1118959006607 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1118959006608 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1118959006609 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1118959006610 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1118959006611 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1118959006612 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1118959006613 DNA topoisomerase III; Provisional; Region: PRK07726 1118959006614 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1118959006615 active site 1118959006616 putative interdomain interaction site [polypeptide binding]; other site 1118959006617 putative metal-binding site [ion binding]; other site 1118959006618 putative nucleotide binding site [chemical binding]; other site 1118959006619 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1118959006620 domain I; other site 1118959006621 DNA binding groove [nucleotide binding] 1118959006622 phosphate binding site [ion binding]; other site 1118959006623 domain II; other site 1118959006624 domain III; other site 1118959006625 nucleotide binding site [chemical binding]; other site 1118959006626 catalytic site [active] 1118959006627 domain IV; other site 1118959006628 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1118959006629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959006630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1118959006631 Coenzyme A binding pocket [chemical binding]; other site 1118959006632 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1118959006633 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1118959006634 Predicted permeases [General function prediction only]; Region: COG0679 1118959006635 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1118959006636 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1118959006637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1118959006638 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1118959006639 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1118959006640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959006641 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1118959006642 putative substrate translocation pore; other site 1118959006643 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959006644 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1118959006645 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1118959006646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1118959006647 FeS/SAM binding site; other site 1118959006648 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1118959006649 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1118959006650 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1118959006651 GTP binding site; other site 1118959006652 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1118959006653 MoaE interaction surface [polypeptide binding]; other site 1118959006654 MoeB interaction surface [polypeptide binding]; other site 1118959006655 thiocarboxylated glycine; other site 1118959006656 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1118959006657 MoaE homodimer interface [polypeptide binding]; other site 1118959006658 MoaD interaction [polypeptide binding]; other site 1118959006659 active site residues [active] 1118959006660 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 1118959006661 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1118959006662 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1118959006663 dimer interface [polypeptide binding]; other site 1118959006664 putative functional site; other site 1118959006665 putative MPT binding site; other site 1118959006666 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1118959006667 trimer interface [polypeptide binding]; other site 1118959006668 dimer interface [polypeptide binding]; other site 1118959006669 putative active site [active] 1118959006670 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1118959006671 MPT binding site; other site 1118959006672 trimer interface [polypeptide binding]; other site 1118959006673 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1118959006674 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1118959006675 ATP binding site [chemical binding]; other site 1118959006676 substrate interface [chemical binding]; other site 1118959006677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959006678 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1118959006679 Walker A/P-loop; other site 1118959006680 ATP binding site [chemical binding]; other site 1118959006681 Q-loop/lid; other site 1118959006682 ABC transporter signature motif; other site 1118959006683 Walker B; other site 1118959006684 D-loop; other site 1118959006685 H-loop/switch region; other site 1118959006686 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1118959006687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959006688 dimer interface [polypeptide binding]; other site 1118959006689 conserved gate region; other site 1118959006690 putative PBP binding loops; other site 1118959006691 ABC-ATPase subunit interface; other site 1118959006692 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1118959006693 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1118959006694 substrate binding pocket [chemical binding]; other site 1118959006695 membrane-bound complex binding site; other site 1118959006696 hinge residues; other site 1118959006697 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1118959006698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959006699 Coenzyme A binding pocket [chemical binding]; other site 1118959006700 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1118959006701 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1118959006702 active site 1118959006703 dimerization interface [polypeptide binding]; other site 1118959006704 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1118959006705 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1118959006706 intersubunit interface [polypeptide binding]; other site 1118959006707 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1118959006708 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1118959006709 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 1118959006710 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1118959006711 alpha-gamma subunit interface [polypeptide binding]; other site 1118959006712 beta-gamma subunit interface [polypeptide binding]; other site 1118959006713 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1118959006714 gamma-beta subunit interface [polypeptide binding]; other site 1118959006715 alpha-beta subunit interface [polypeptide binding]; other site 1118959006716 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1118959006717 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1118959006718 subunit interactions [polypeptide binding]; other site 1118959006719 active site 1118959006720 flap region; other site 1118959006721 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1118959006722 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1118959006723 dimer interface [polypeptide binding]; other site 1118959006724 catalytic residues [active] 1118959006725 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1118959006726 UreF; Region: UreF; pfam01730 1118959006727 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1118959006728 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1118959006729 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959006730 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959006731 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959006732 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1118959006733 Helix-turn-helix domain; Region: HTH_18; pfam12833 1118959006734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1118959006735 Surface antigen [General function prediction only]; Region: COG3942 1118959006736 CHAP domain; Region: CHAP; pfam05257 1118959006737 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1118959006738 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1118959006739 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1118959006740 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1118959006741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1118959006742 Surface antigen [General function prediction only]; Region: COG3942 1118959006743 CHAP domain; Region: CHAP; pfam05257 1118959006744 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1118959006745 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1118959006746 putative ligand binding site [chemical binding]; other site 1118959006747 putative NAD binding site [chemical binding]; other site 1118959006748 catalytic site [active] 1118959006749 hypothetical protein; Provisional; Region: PRK06753 1118959006750 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1118959006751 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1118959006752 Lysozyme subfamily 2; Region: LYZ2; smart00047 1118959006753 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1118959006754 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1118959006755 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1118959006756 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1118959006757 4Fe-4S binding domain; Region: Fer4; pfam00037 1118959006758 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1118959006759 [4Fe-4S] binding site [ion binding]; other site 1118959006760 molybdopterin cofactor binding site; other site 1118959006761 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1118959006762 molybdopterin cofactor binding site; other site 1118959006763 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1118959006764 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1118959006765 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1118959006766 active site 1118959006767 Predicted transcriptional regulator [Transcription]; Region: COG2378 1118959006768 HTH domain; Region: HTH_11; pfam08279 1118959006769 CAAX protease self-immunity; Region: Abi; pfam02517 1118959006770 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1118959006771 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1118959006772 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1118959006773 putative active site [active] 1118959006774 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1118959006775 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1118959006776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959006777 active site 1118959006778 motif I; other site 1118959006779 motif II; other site 1118959006780 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1118959006781 Sodium Bile acid symporter family; Region: SBF; pfam01758 1118959006782 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1118959006783 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1118959006784 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1118959006785 active site turn [active] 1118959006786 phosphorylation site [posttranslational modification] 1118959006787 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1118959006788 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1118959006789 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1118959006790 putative active site [active] 1118959006791 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1118959006792 putative hydrophobic ligand binding site [chemical binding]; other site 1118959006793 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1118959006794 oxidoreductase; Provisional; Region: PRK07985 1118959006795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1118959006796 NAD(P) binding site [chemical binding]; other site 1118959006797 active site 1118959006798 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1118959006799 amidohydrolase; Region: amidohydrolases; TIGR01891 1118959006800 metal binding site [ion binding]; metal-binding site 1118959006801 dimer interface [polypeptide binding]; other site 1118959006802 imidazolonepropionase; Validated; Region: PRK09356 1118959006803 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1118959006804 active site 1118959006805 urocanate hydratase; Provisional; Region: PRK05414 1118959006806 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1118959006807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1118959006808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1118959006809 dimerization interface [polypeptide binding]; other site 1118959006810 formimidoylglutamase; Provisional; Region: PRK13775 1118959006811 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1118959006812 putative active site [active] 1118959006813 putative metal binding site [ion binding]; other site 1118959006814 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1118959006815 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1118959006816 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1118959006817 active site 1118959006818 dimer interface [polypeptide binding]; other site 1118959006819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1118959006820 MOSC domain; Region: MOSC; pfam03473 1118959006821 3-alpha domain; Region: 3-alpha; pfam03475 1118959006822 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1118959006823 active site 1118959006824 catalytic residues [active] 1118959006825 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 1118959006826 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 1118959006827 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1118959006828 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1118959006829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959006830 Walker A/P-loop; other site 1118959006831 ATP binding site [chemical binding]; other site 1118959006832 Q-loop/lid; other site 1118959006833 ABC transporter signature motif; other site 1118959006834 Walker B; other site 1118959006835 D-loop; other site 1118959006836 H-loop/switch region; other site 1118959006837 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1118959006838 Predicted membrane protein [Function unknown]; Region: COG3152 1118959006839 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1118959006840 active site 1118959006841 DNA binding site [nucleotide binding] 1118959006842 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1118959006843 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1118959006844 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1118959006845 homotetramer interface [polypeptide binding]; other site 1118959006846 FMN binding site [chemical binding]; other site 1118959006847 homodimer contacts [polypeptide binding]; other site 1118959006848 putative active site [active] 1118959006849 putative substrate binding site [chemical binding]; other site 1118959006850 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1118959006851 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1118959006852 oligomer interface [polypeptide binding]; other site 1118959006853 metal binding site [ion binding]; metal-binding site 1118959006854 metal binding site [ion binding]; metal-binding site 1118959006855 putative Cl binding site [ion binding]; other site 1118959006856 aspartate ring; other site 1118959006857 basic sphincter; other site 1118959006858 hydrophobic gate; other site 1118959006859 periplasmic entrance; other site 1118959006860 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1118959006861 active site 1118959006862 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1118959006863 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1118959006864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959006865 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1118959006866 putative substrate translocation pore; other site 1118959006867 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1118959006868 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1118959006869 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1118959006870 HlyD family secretion protein; Region: HlyD_3; pfam13437 1118959006871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1118959006872 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959006873 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1118959006874 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959006875 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1118959006876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959006877 putative substrate translocation pore; other site 1118959006878 Predicted membrane protein [Function unknown]; Region: COG4640 1118959006879 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1118959006880 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1118959006881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1118959006882 putative Zn2+ binding site [ion binding]; other site 1118959006883 putative DNA binding site [nucleotide binding]; other site 1118959006884 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1118959006885 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1118959006886 putative active site [active] 1118959006887 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1118959006888 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1118959006889 Walker A/P-loop; other site 1118959006890 ATP binding site [chemical binding]; other site 1118959006891 Q-loop/lid; other site 1118959006892 ABC transporter signature motif; other site 1118959006893 Walker B; other site 1118959006894 D-loop; other site 1118959006895 H-loop/switch region; other site 1118959006896 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1118959006897 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1118959006898 FtsX-like permease family; Region: FtsX; pfam02687 1118959006899 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1118959006900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959006901 active site 1118959006902 phosphorylation site [posttranslational modification] 1118959006903 intermolecular recognition site; other site 1118959006904 dimerization interface [polypeptide binding]; other site 1118959006905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1118959006906 DNA binding site [nucleotide binding] 1118959006907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1118959006908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1118959006909 dimerization interface [polypeptide binding]; other site 1118959006910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1118959006911 dimer interface [polypeptide binding]; other site 1118959006912 phosphorylation site [posttranslational modification] 1118959006913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959006914 ATP binding site [chemical binding]; other site 1118959006915 Mg2+ binding site [ion binding]; other site 1118959006916 G-X-G motif; other site 1118959006917 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1118959006918 LytTr DNA-binding domain; Region: LytTR; smart00850 1118959006919 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1118959006920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1118959006921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1118959006922 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1118959006923 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1118959006924 Walker A/P-loop; other site 1118959006925 ATP binding site [chemical binding]; other site 1118959006926 Q-loop/lid; other site 1118959006927 ABC transporter signature motif; other site 1118959006928 Walker B; other site 1118959006929 D-loop; other site 1118959006930 H-loop/switch region; other site 1118959006931 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1118959006932 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1118959006933 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 1118959006934 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1118959006935 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1118959006936 L-lactate permease; Region: Lactate_perm; cl00701 1118959006937 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1118959006938 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1118959006939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959006940 Coenzyme A binding pocket [chemical binding]; other site 1118959006941 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1118959006942 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1118959006943 NAD(P) binding site [chemical binding]; other site 1118959006944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959006945 Coenzyme A binding pocket [chemical binding]; other site 1118959006946 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1118959006947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1118959006948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959006949 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1118959006950 Predicted membrane protein [Function unknown]; Region: COG1511 1118959006951 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1118959006952 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1118959006953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1118959006954 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1118959006955 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1118959006956 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1118959006957 Cl binding site [ion binding]; other site 1118959006958 oligomer interface [polypeptide binding]; other site 1118959006959 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1118959006960 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1118959006961 active site turn [active] 1118959006962 phosphorylation site [posttranslational modification] 1118959006963 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1118959006964 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1118959006965 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1118959006966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1118959006967 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1118959006968 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1118959006969 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1118959006970 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1118959006971 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1118959006972 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1118959006973 MarR family; Region: MarR_2; pfam12802 1118959006974 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1118959006975 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1118959006976 putative dimer interface [polypeptide binding]; other site 1118959006977 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1118959006978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959006979 putative substrate translocation pore; other site 1118959006980 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1118959006981 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1118959006982 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1118959006983 DNA binding residues [nucleotide binding] 1118959006984 dimer interface [polypeptide binding]; other site 1118959006985 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1118959006986 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1118959006987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959006988 active site 1118959006989 phosphorylation site [posttranslational modification] 1118959006990 intermolecular recognition site; other site 1118959006991 dimerization interface [polypeptide binding]; other site 1118959006992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1118959006993 DNA binding residues [nucleotide binding] 1118959006994 dimerization interface [polypeptide binding]; other site 1118959006995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1118959006996 Histidine kinase; Region: HisKA_3; pfam07730 1118959006997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959006998 ATP binding site [chemical binding]; other site 1118959006999 Mg2+ binding site [ion binding]; other site 1118959007000 G-X-G motif; other site 1118959007001 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1118959007002 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1118959007003 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1118959007004 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1118959007005 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1118959007006 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1118959007007 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1118959007008 [4Fe-4S] binding site [ion binding]; other site 1118959007009 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1118959007010 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1118959007011 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1118959007012 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1118959007013 molybdopterin cofactor binding site; other site 1118959007014 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1118959007015 active site 1118959007016 SAM binding site [chemical binding]; other site 1118959007017 homodimer interface [polypeptide binding]; other site 1118959007018 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1118959007019 [2Fe-2S] cluster binding site [ion binding]; other site 1118959007020 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1118959007021 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1118959007022 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1118959007023 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1118959007024 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1118959007025 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1118959007026 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1118959007027 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1118959007028 putative active site [active] 1118959007029 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1118959007030 active site 1118959007031 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1118959007032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959007033 Coenzyme A binding pocket [chemical binding]; other site 1118959007034 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1118959007035 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1118959007036 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1118959007037 putative hydrophobic ligand binding site [chemical binding]; other site 1118959007038 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1118959007039 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1118959007040 intersubunit interface [polypeptide binding]; other site 1118959007041 YodA lipocalin-like domain; Region: YodA; pfam09223 1118959007042 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1118959007043 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1118959007044 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1118959007045 Thioredoxin; Region: Thioredoxin_4; cl17273 1118959007046 FemAB family; Region: FemAB; pfam02388 1118959007047 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1118959007048 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1118959007049 Walker A/P-loop; other site 1118959007050 ATP binding site [chemical binding]; other site 1118959007051 Q-loop/lid; other site 1118959007052 ABC transporter signature motif; other site 1118959007053 Walker B; other site 1118959007054 D-loop; other site 1118959007055 H-loop/switch region; other site 1118959007056 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1118959007057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959007058 dimer interface [polypeptide binding]; other site 1118959007059 conserved gate region; other site 1118959007060 putative PBP binding loops; other site 1118959007061 ABC-ATPase subunit interface; other site 1118959007062 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1118959007063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1118959007064 substrate binding pocket [chemical binding]; other site 1118959007065 membrane-bound complex binding site; other site 1118959007066 hinge residues; other site 1118959007067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959007068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1118959007069 putative substrate translocation pore; other site 1118959007070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959007071 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1118959007072 catalytic core [active] 1118959007073 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1118959007074 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1118959007075 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1118959007076 B domain; Region: B; pfam02216 1118959007077 B domain; Region: B; pfam02216 1118959007078 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 1118959007079 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1118959007080 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1118959007081 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1118959007082 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1118959007083 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1118959007084 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1118959007085 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1118959007086 catalytic residue [active] 1118959007087 biotin synthase; Validated; Region: PRK06256 1118959007088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1118959007089 FeS/SAM binding site; other site 1118959007090 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1118959007091 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1118959007092 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1118959007093 inhibitor-cofactor binding pocket; inhibition site 1118959007094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959007095 catalytic residue [active] 1118959007096 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1118959007097 AAA domain; Region: AAA_26; pfam13500 1118959007098 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1118959007099 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1118959007100 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1118959007101 Walker A/P-loop; other site 1118959007102 ATP binding site [chemical binding]; other site 1118959007103 Q-loop/lid; other site 1118959007104 ABC transporter signature motif; other site 1118959007105 Walker B; other site 1118959007106 D-loop; other site 1118959007107 H-loop/switch region; other site 1118959007108 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1118959007109 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1118959007110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959007111 Walker A/P-loop; other site 1118959007112 ATP binding site [chemical binding]; other site 1118959007113 Q-loop/lid; other site 1118959007114 ABC transporter signature motif; other site 1118959007115 Walker B; other site 1118959007116 D-loop; other site 1118959007117 H-loop/switch region; other site 1118959007118 Predicted membrane protein [Function unknown]; Region: COG2246 1118959007119 GtrA-like protein; Region: GtrA; pfam04138 1118959007120 glycerate kinase; Region: TIGR00045 1118959007121 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1118959007122 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1118959007123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959007124 putative substrate translocation pore; other site 1118959007125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1118959007126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1118959007127 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1118959007128 putative phosphoesterase; Region: acc_ester; TIGR03729 1118959007129 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1118959007130 Spore germination protein; Region: Spore_permease; cl17796 1118959007131 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1118959007132 Amino acid permease; Region: AA_permease_2; pfam13520 1118959007133 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1118959007134 Beta-lactamase; Region: Beta-lactamase; pfam00144 1118959007135 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1118959007136 extended (e) SDRs; Region: SDR_e; cd08946 1118959007137 NAD(P) binding site [chemical binding]; other site 1118959007138 active site 1118959007139 substrate binding site [chemical binding]; other site 1118959007140 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1118959007141 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1118959007142 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1118959007143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959007144 putative substrate translocation pore; other site 1118959007145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959007146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959007147 dimer interface [polypeptide binding]; other site 1118959007148 conserved gate region; other site 1118959007149 ABC-ATPase subunit interface; other site 1118959007150 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1118959007151 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1118959007152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959007153 dimer interface [polypeptide binding]; other site 1118959007154 conserved gate region; other site 1118959007155 putative PBP binding loops; other site 1118959007156 ABC-ATPase subunit interface; other site 1118959007157 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1118959007158 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1118959007159 Walker A/P-loop; other site 1118959007160 ATP binding site [chemical binding]; other site 1118959007161 Q-loop/lid; other site 1118959007162 ABC transporter signature motif; other site 1118959007163 Walker B; other site 1118959007164 D-loop; other site 1118959007165 H-loop/switch region; other site 1118959007166 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1118959007167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1118959007168 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1118959007169 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1118959007170 amino acid transporter; Region: 2A0306; TIGR00909 1118959007171 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1118959007172 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1118959007173 substrate binding pocket [chemical binding]; other site 1118959007174 catalytic triad [active] 1118959007175 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1118959007176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959007177 putative substrate translocation pore; other site 1118959007178 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1118959007179 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1118959007180 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1118959007181 Walker A/P-loop; other site 1118959007182 ATP binding site [chemical binding]; other site 1118959007183 Q-loop/lid; other site 1118959007184 ABC transporter signature motif; other site 1118959007185 Walker B; other site 1118959007186 D-loop; other site 1118959007187 H-loop/switch region; other site 1118959007188 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1118959007189 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1118959007190 oligomer interface [polypeptide binding]; other site 1118959007191 active site 1118959007192 metal binding site [ion binding]; metal-binding site 1118959007193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1118959007194 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1118959007195 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1118959007196 active site 1118959007197 FMN binding site [chemical binding]; other site 1118959007198 substrate binding site [chemical binding]; other site 1118959007199 3Fe-4S cluster binding site [ion binding]; other site 1118959007200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959007201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1118959007202 putative substrate translocation pore; other site 1118959007203 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1118959007204 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1118959007205 Walker A/P-loop; other site 1118959007206 ATP binding site [chemical binding]; other site 1118959007207 Q-loop/lid; other site 1118959007208 ABC transporter signature motif; other site 1118959007209 Walker B; other site 1118959007210 D-loop; other site 1118959007211 H-loop/switch region; other site 1118959007212 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1118959007213 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1118959007214 Walker A/P-loop; other site 1118959007215 ATP binding site [chemical binding]; other site 1118959007216 Q-loop/lid; other site 1118959007217 ABC transporter signature motif; other site 1118959007218 Walker B; other site 1118959007219 D-loop; other site 1118959007220 H-loop/switch region; other site 1118959007221 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1118959007222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1118959007223 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1118959007224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959007225 dimer interface [polypeptide binding]; other site 1118959007226 conserved gate region; other site 1118959007227 putative PBP binding loops; other site 1118959007228 ABC-ATPase subunit interface; other site 1118959007229 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1118959007230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1118959007231 dimer interface [polypeptide binding]; other site 1118959007232 conserved gate region; other site 1118959007233 putative PBP binding loops; other site 1118959007234 ABC-ATPase subunit interface; other site 1118959007235 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1118959007236 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1118959007237 substrate binding site [chemical binding]; other site 1118959007238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1118959007239 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1118959007240 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1118959007241 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1118959007242 short chain dehydrogenase; Validated; Region: PRK08589 1118959007243 classical (c) SDRs; Region: SDR_c; cd05233 1118959007244 NAD(P) binding site [chemical binding]; other site 1118959007245 active site 1118959007246 AbgT putative transporter family; Region: ABG_transport; cl17431 1118959007247 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1118959007248 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1118959007249 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1118959007250 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1118959007251 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1118959007252 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1118959007253 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1118959007254 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1118959007255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1118959007256 NAD(P) binding site [chemical binding]; other site 1118959007257 active site 1118959007258 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1118959007259 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1118959007260 potential frameshift: common BLAST hit: gi|269204118|ref|YP_003283387.1| putative lipoprotein 1118959007261 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959007262 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959007263 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1118959007264 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1118959007265 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959007266 Protein of unknown function, DUF576; Region: DUF576; cl04553 1118959007267 potential frameshift: common BLAST hit: gi|49484698|ref|YP_041922.1| helicase 1118959007268 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1118959007269 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1118959007270 PLD-like domain; Region: PLDc_2; pfam13091 1118959007271 putative homodimer interface [polypeptide binding]; other site 1118959007272 putative active site [active] 1118959007273 catalytic site [active] 1118959007274 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1118959007275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1118959007276 ATP binding site [chemical binding]; other site 1118959007277 putative Mg++ binding site [ion binding]; other site 1118959007278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1118959007279 nucleotide binding region [chemical binding]; other site 1118959007280 ATP-binding site [chemical binding]; other site 1118959007281 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1118959007282 active site 1118959007283 8-oxo-dGMP binding site [chemical binding]; other site 1118959007284 nudix motif; other site 1118959007285 metal binding site [ion binding]; metal-binding site 1118959007286 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1118959007287 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1118959007288 active site 1118959007289 substrate binding site [chemical binding]; other site 1118959007290 metal binding site [ion binding]; metal-binding site 1118959007291 H+ Antiporter protein; Region: 2A0121; TIGR00900 1118959007292 potential frameshift: common BLAST hit: gi|49487275|ref|YP_044496.1| cell wall-anchored protein 1118959007293 G5 domain; Region: G5; pfam07501 1118959007294 G5 domain; Region: G5; pfam07501 1118959007295 G5 domain; Region: G5; pfam07501 1118959007296 potential frameshift: common BLAST hit: gi|49487275|ref|YP_044496.1| cell wall-anchored protein 1118959007297 G5 domain; Region: G5; pfam07501 1118959007298 G5 domain; Region: G5; pfam07501 1118959007299 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1118959007300 G5 domain; Region: G5; pfam07501 1118959007301 G5 domain; Region: G5; pfam07501 1118959007302 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959007303 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1118959007304 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959007305 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1118959007306 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1118959007307 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1118959007308 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1118959007309 active site 1118959007310 tetramer interface; other site 1118959007311 Mucin-like glycoprotein; Region: Mucin; pfam01456 1118959007312 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1118959007313 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1118959007314 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1118959007315 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1118959007316 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1118959007317 GntP family permease; Region: GntP_permease; pfam02447 1118959007318 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1118959007319 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1118959007320 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1118959007321 N- and C-terminal domain interface [polypeptide binding]; other site 1118959007322 active site 1118959007323 catalytic site [active] 1118959007324 metal binding site [ion binding]; metal-binding site 1118959007325 carbohydrate binding site [chemical binding]; other site 1118959007326 ATP binding site [chemical binding]; other site 1118959007327 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1118959007328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1118959007329 DNA-binding site [nucleotide binding]; DNA binding site 1118959007330 FCD domain; Region: FCD; pfam07729 1118959007331 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1118959007332 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1118959007333 DNA binding residues [nucleotide binding] 1118959007334 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1118959007335 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1118959007336 synthetase active site [active] 1118959007337 NTP binding site [chemical binding]; other site 1118959007338 metal binding site [ion binding]; metal-binding site 1118959007339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1118959007340 Predicted membrane protein [Function unknown]; Region: COG1289 1118959007341 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1118959007342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1118959007343 D-galactonate transporter; Region: 2A0114; TIGR00893 1118959007344 putative substrate translocation pore; other site 1118959007345 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1118959007346 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1118959007347 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1118959007348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959007349 Walker A/P-loop; other site 1118959007350 ATP binding site [chemical binding]; other site 1118959007351 Q-loop/lid; other site 1118959007352 ABC transporter signature motif; other site 1118959007353 Walker B; other site 1118959007354 D-loop; other site 1118959007355 H-loop/switch region; other site 1118959007356 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1118959007357 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1118959007358 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1118959007359 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1118959007360 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1118959007361 putative NAD(P) binding site [chemical binding]; other site 1118959007362 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1118959007363 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1118959007364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1118959007365 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1118959007366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1118959007367 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959007368 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1118959007369 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1118959007370 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1118959007371 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1118959007372 Predicted esterase [General function prediction only]; Region: COG0400 1118959007373 putative hydrolase; Provisional; Region: PRK11460 1118959007374 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1118959007375 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1118959007376 Zn binding site [ion binding]; other site 1118959007377 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1118959007378 Zn binding site [ion binding]; other site 1118959007379 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1118959007380 MarR family; Region: MarR; pfam01047 1118959007381 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1118959007382 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1118959007383 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1118959007384 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1118959007385 putative metal binding site [ion binding]; other site 1118959007386 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1118959007387 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1118959007388 dimer interface [polypeptide binding]; other site 1118959007389 FMN binding site [chemical binding]; other site 1118959007390 D-lactate dehydrogenase; Provisional; Region: PRK12480 1118959007391 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1118959007392 homodimer interface [polypeptide binding]; other site 1118959007393 ligand binding site [chemical binding]; other site 1118959007394 NAD binding site [chemical binding]; other site 1118959007395 catalytic site [active] 1118959007396 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1118959007397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1118959007398 active site 1118959007399 motif I; other site 1118959007400 motif II; other site 1118959007401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1118959007402 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1118959007403 Walker A/P-loop; other site 1118959007404 ATP binding site [chemical binding]; other site 1118959007405 Q-loop/lid; other site 1118959007406 ABC transporter signature motif; other site 1118959007407 Walker B; other site 1118959007408 D-loop; other site 1118959007409 H-loop/switch region; other site 1118959007410 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1118959007411 active site 1118959007412 catalytic site [active] 1118959007413 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1118959007414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959007415 Coenzyme A binding pocket [chemical binding]; other site 1118959007416 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1118959007417 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1118959007418 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1118959007419 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1118959007420 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1118959007421 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1118959007422 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1118959007423 EamA-like transporter family; Region: EamA; pfam00892 1118959007424 EamA-like transporter family; Region: EamA; pfam00892 1118959007425 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1118959007426 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1118959007427 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1118959007428 catalytic residues [active] 1118959007429 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1118959007430 active site 1118959007431 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1118959007432 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1118959007433 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1118959007434 active site turn [active] 1118959007435 phosphorylation site [posttranslational modification] 1118959007436 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1118959007437 HPr interaction site; other site 1118959007438 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1118959007439 active site 1118959007440 phosphorylation site [posttranslational modification] 1118959007441 pyruvate oxidase; Provisional; Region: PRK08611 1118959007442 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1118959007443 PYR/PP interface [polypeptide binding]; other site 1118959007444 tetramer interface [polypeptide binding]; other site 1118959007445 dimer interface [polypeptide binding]; other site 1118959007446 TPP binding site [chemical binding]; other site 1118959007447 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1118959007448 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1118959007449 TPP-binding site [chemical binding]; other site 1118959007450 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1118959007451 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1118959007452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1118959007453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1118959007454 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1118959007455 putative dimerization interface [polypeptide binding]; other site 1118959007456 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1118959007457 Surface antigen [General function prediction only]; Region: COG3942 1118959007458 CHAP domain; Region: CHAP; pfam05257 1118959007459 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1118959007460 homodimer interface [polypeptide binding]; other site 1118959007461 catalytic residues [active] 1118959007462 NAD binding site [chemical binding]; other site 1118959007463 substrate binding pocket [chemical binding]; other site 1118959007464 flexible flap; other site 1118959007465 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1118959007466 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1118959007467 dimer interface [polypeptide binding]; other site 1118959007468 active site 1118959007469 superantigen-like protein; Reviewed; Region: PRK13037 1118959007470 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1118959007471 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1118959007472 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1118959007473 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1118959007474 DNA binding site [nucleotide binding] 1118959007475 active site 1118959007476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959007477 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1118959007478 Walker A motif; other site 1118959007479 ATP binding site [chemical binding]; other site 1118959007480 Walker B motif; other site 1118959007481 arginine finger; other site 1118959007482 UvrB/uvrC motif; Region: UVR; pfam02151 1118959007483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1118959007484 Walker A motif; other site 1118959007485 ATP binding site [chemical binding]; other site 1118959007486 Walker B motif; other site 1118959007487 arginine finger; other site 1118959007488 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1118959007489 Virus attachment protein p12 family; Region: P12; pfam12669 1118959007490 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1118959007491 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1118959007492 G1 box; other site 1118959007493 GTP/Mg2+ binding site [chemical binding]; other site 1118959007494 Switch I region; other site 1118959007495 G2 box; other site 1118959007496 G3 box; other site 1118959007497 Switch II region; other site 1118959007498 G4 box; other site 1118959007499 G5 box; other site 1118959007500 Nucleoside recognition; Region: Gate; pfam07670 1118959007501 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1118959007502 Nucleoside recognition; Region: Gate; pfam07670 1118959007503 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1118959007504 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1118959007505 Protein export membrane protein; Region: SecD_SecF; cl14618 1118959007506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1118959007507 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1118959007508 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1118959007509 Glutamate binding site [chemical binding]; other site 1118959007510 homodimer interface [polypeptide binding]; other site 1118959007511 NAD binding site [chemical binding]; other site 1118959007512 catalytic residues [active] 1118959007513 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1118959007514 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1118959007515 active site 1118959007516 substrate binding site [chemical binding]; other site 1118959007517 trimer interface [polypeptide binding]; other site 1118959007518 CoA binding site [chemical binding]; other site 1118959007519 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1118959007520 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1118959007521 metal-binding site [ion binding] 1118959007522 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1118959007523 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1118959007524 metal-binding site [ion binding] 1118959007525 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1118959007526 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1118959007527 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1118959007528 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1118959007529 metal-binding site [ion binding] 1118959007530 D-lactate dehydrogenase; Validated; Region: PRK08605 1118959007531 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1118959007532 homodimer interface [polypeptide binding]; other site 1118959007533 ligand binding site [chemical binding]; other site 1118959007534 NAD binding site [chemical binding]; other site 1118959007535 catalytic site [active] 1118959007536 transaminase; Reviewed; Region: PRK08068 1118959007537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1118959007538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959007539 homodimer interface [polypeptide binding]; other site 1118959007540 catalytic residue [active] 1118959007541 phytoene desaturase; Region: crtI_fam; TIGR02734 1118959007542 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1118959007543 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1118959007544 active site lid residues [active] 1118959007545 substrate binding pocket [chemical binding]; other site 1118959007546 catalytic residues [active] 1118959007547 substrate-Mg2+ binding site; other site 1118959007548 aspartate-rich region 1; other site 1118959007549 aspartate-rich region 2; other site 1118959007550 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1118959007551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1118959007552 active site 1118959007553 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1118959007554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1118959007555 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237 1118959007556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1118959007557 Surface antigen [General function prediction only]; Region: COG3942 1118959007558 CHAP domain; Region: CHAP; pfam05257 1118959007559 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1118959007560 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1118959007561 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1118959007562 catalytic triad [active] 1118959007563 catalytic triad [active] 1118959007564 oxyanion hole [active] 1118959007565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959007566 Coenzyme A binding pocket [chemical binding]; other site 1118959007567 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1118959007568 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1118959007569 catalytic residue [active] 1118959007570 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1118959007571 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1118959007572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1118959007573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1118959007574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1118959007575 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1118959007576 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1118959007577 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1118959007578 NmrA-like family; Region: NmrA; pfam05368 1118959007579 NADP binding site [chemical binding]; other site 1118959007580 active site 1118959007581 regulatory binding site [polypeptide binding]; other site 1118959007582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 1118959007583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1118959007584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1118959007585 short chain dehydrogenase; Provisional; Region: PRK12937 1118959007586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1118959007587 NAD(P) binding site [chemical binding]; other site 1118959007588 active site 1118959007589 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1118959007590 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1118959007591 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1118959007592 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1118959007593 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1118959007594 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1118959007595 Nucleoside recognition; Region: Gate; pfam07670 1118959007596 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1118959007597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1118959007598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 1118959007599 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 1118959007600 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1118959007601 Phosphotransferase enzyme family; Region: APH; pfam01636 1118959007602 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1118959007603 active site 1118959007604 ATP binding site [chemical binding]; other site 1118959007605 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1118959007606 active site 1118959007607 ATP binding site [chemical binding]; other site 1118959007608 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1118959007609 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1118959007610 quinone interaction residues [chemical binding]; other site 1118959007611 active site 1118959007612 catalytic residues [active] 1118959007613 FMN binding site [chemical binding]; other site 1118959007614 substrate binding site [chemical binding]; other site 1118959007615 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 1118959007616 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1118959007617 dimer interface [polypeptide binding]; other site 1118959007618 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1118959007619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1118959007620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1118959007621 Predicted acyl esterases [General function prediction only]; Region: COG2936 1118959007622 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1118959007623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1118959007624 Integrase core domain; Region: rve; pfam00665 1118959007625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1118959007626 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1118959007627 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1118959007628 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1118959007629 tetramerization interface [polypeptide binding]; other site 1118959007630 active site 1118959007631 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1118959007632 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1118959007633 active site 1118959007634 ATP-binding site [chemical binding]; other site 1118959007635 pantoate-binding site; other site 1118959007636 HXXH motif; other site 1118959007637 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1118959007638 oligomerization interface [polypeptide binding]; other site 1118959007639 active site 1118959007640 metal binding site [ion binding]; metal-binding site 1118959007641 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1118959007642 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1118959007643 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1118959007644 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1118959007645 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1118959007646 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1118959007647 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1118959007648 NAD binding site [chemical binding]; other site 1118959007649 dimer interface [polypeptide binding]; other site 1118959007650 substrate binding site [chemical binding]; other site 1118959007651 amino acid transporter; Region: 2A0306; TIGR00909 1118959007652 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1118959007653 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1118959007654 inhibitor-cofactor binding pocket; inhibition site 1118959007655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959007656 catalytic residue [active] 1118959007657 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1118959007658 catalytic residue [active] 1118959007659 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1118959007660 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1118959007661 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1118959007662 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1118959007663 acyl-activating enzyme (AAE) consensus motif; other site 1118959007664 AMP binding site [chemical binding]; other site 1118959007665 active site 1118959007666 CoA binding site [chemical binding]; other site 1118959007667 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1118959007668 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1118959007669 choline dehydrogenase; Validated; Region: PRK02106 1118959007670 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1118959007671 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1118959007672 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1118959007673 tetramerization interface [polypeptide binding]; other site 1118959007674 NAD(P) binding site [chemical binding]; other site 1118959007675 catalytic residues [active] 1118959007676 Predicted transcriptional regulators [Transcription]; Region: COG1510 1118959007677 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1118959007678 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1118959007679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1118959007680 FeS/SAM binding site; other site 1118959007681 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1118959007682 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1118959007683 effector binding site; other site 1118959007684 active site 1118959007685 Zn binding site [ion binding]; other site 1118959007686 glycine loop; other site 1118959007687 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1118959007688 Citrate transporter; Region: CitMHS; pfam03600 1118959007689 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1118959007690 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1118959007691 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1118959007692 Flavodoxin; Region: Flavodoxin_1; pfam00258 1118959007693 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1118959007694 FAD binding pocket [chemical binding]; other site 1118959007695 FAD binding motif [chemical binding]; other site 1118959007696 catalytic residues [active] 1118959007697 NAD binding pocket [chemical binding]; other site 1118959007698 phosphate binding motif [ion binding]; other site 1118959007699 beta-alpha-beta structure motif; other site 1118959007700 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1118959007701 catalytic residues [active] 1118959007702 dimer interface [polypeptide binding]; other site 1118959007703 FtsX-like permease family; Region: FtsX; pfam02687 1118959007704 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1118959007705 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1118959007706 Walker A/P-loop; other site 1118959007707 ATP binding site [chemical binding]; other site 1118959007708 Q-loop/lid; other site 1118959007709 ABC transporter signature motif; other site 1118959007710 Walker B; other site 1118959007711 D-loop; other site 1118959007712 H-loop/switch region; other site 1118959007713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1118959007714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1118959007715 ATP binding site [chemical binding]; other site 1118959007716 Mg2+ binding site [ion binding]; other site 1118959007717 G-X-G motif; other site 1118959007718 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1118959007719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1118959007720 active site 1118959007721 phosphorylation site [posttranslational modification] 1118959007722 intermolecular recognition site; other site 1118959007723 dimerization interface [polypeptide binding]; other site 1118959007724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1118959007725 DNA binding site [nucleotide binding] 1118959007726 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1118959007727 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1118959007728 dimer interface [polypeptide binding]; other site 1118959007729 active site 1118959007730 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1118959007731 potential frameshift: common BLAST hit: gi|15925618|ref|NP_373152.1| transcriptional regulator 1118959007732 Predicted esterase [General function prediction only]; Region: COG0627 1118959007733 S-formylglutathione hydrolase; Region: PLN02442 1118959007734 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1118959007735 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1118959007736 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1118959007737 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1118959007738 ligand binding site [chemical binding]; other site 1118959007739 flexible hinge region; other site 1118959007740 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1118959007741 carbamate kinase; Reviewed; Region: PRK12686 1118959007742 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1118959007743 putative substrate binding site [chemical binding]; other site 1118959007744 nucleotide binding site [chemical binding]; other site 1118959007745 nucleotide binding site [chemical binding]; other site 1118959007746 homodimer interface [polypeptide binding]; other site 1118959007747 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1118959007748 ornithine carbamoyltransferase; Validated; Region: PRK02102 1118959007749 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1118959007750 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1118959007751 arginine deiminase; Provisional; Region: PRK01388 1118959007752 Arginine repressor [Transcription]; Region: ArgR; COG1438 1118959007753 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1118959007754 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1118959007755 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1118959007756 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1118959007757 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1118959007758 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1118959007759 active site 1118959007760 Zn binding site [ion binding]; other site 1118959007761 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1118959007762 HTH domain; Region: HTH_11; pfam08279 1118959007763 PRD domain; Region: PRD; pfam00874 1118959007764 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1118959007765 active site 1118959007766 P-loop; other site 1118959007767 phosphorylation site [posttranslational modification] 1118959007768 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1118959007769 active site 1118959007770 phosphorylation site [posttranslational modification] 1118959007771 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1118959007772 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1118959007773 active site 1118959007774 P-loop; other site 1118959007775 phosphorylation site [posttranslational modification] 1118959007776 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1118959007777 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1118959007778 active site 1118959007779 phosphorylation site [posttranslational modification] 1118959007780 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1118959007781 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1118959007782 Predicted membrane protein [Function unknown]; Region: COG1511 1118959007783 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1118959007784 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1118959007785 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1118959007786 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1118959007787 CHAP domain; Region: CHAP; pfam05257 1118959007788 Isochorismatase family; Region: Isochorismatase; pfam00857 1118959007789 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1118959007790 catalytic triad [active] 1118959007791 conserved cis-peptide bond; other site 1118959007792 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1118959007793 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1118959007794 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1118959007795 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1118959007796 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1118959007797 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1118959007798 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1118959007799 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1118959007800 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1118959007801 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1118959007802 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1118959007803 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1118959007804 SecY translocase; Region: SecY; pfam00344 1118959007805 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1118959007806 legume lectins; Region: lectin_L-type; cd01951 1118959007807 homotetramer interaction site [polypeptide binding]; other site 1118959007808 carbohydrate binding site [chemical binding]; other site 1118959007809 metal binding site [ion binding]; metal-binding site 1118959007810 Putative Ig domain; Region: He_PIG; pfam05345 1118959007811 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1118959007812 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1118959007813 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1118959007814 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1118959007815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1118959007816 Coenzyme A binding pocket [chemical binding]; other site 1118959007817 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1118959007818 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1118959007819 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1118959007820 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1118959007821 Chain length determinant protein; Region: Wzz; cl15801 1118959007822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1118959007823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1118959007824 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1118959007825 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1118959007826 DXD motif; other site 1118959007827 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 1118959007828 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 1118959007829 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1118959007830 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1118959007831 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1118959007832 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1118959007833 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1118959007834 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1118959007835 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1118959007836 metal binding site [ion binding]; metal-binding site 1118959007837 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1118959007838 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1118959007839 substrate binding site [chemical binding]; other site 1118959007840 glutamase interaction surface [polypeptide binding]; other site 1118959007841 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1118959007842 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1118959007843 catalytic residues [active] 1118959007844 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 1118959007845 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1118959007846 putative active site [active] 1118959007847 oxyanion strand; other site 1118959007848 catalytic triad [active] 1118959007849 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1118959007850 putative active site pocket [active] 1118959007851 4-fold oligomerization interface [polypeptide binding]; other site 1118959007852 metal binding residues [ion binding]; metal-binding site 1118959007853 3-fold/trimer interface [polypeptide binding]; other site 1118959007854 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1118959007855 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1118959007856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1118959007857 homodimer interface [polypeptide binding]; other site 1118959007858 catalytic residue [active] 1118959007859 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1118959007860 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1118959007861 NAD binding site [chemical binding]; other site 1118959007862 dimerization interface [polypeptide binding]; other site 1118959007863 product binding site; other site 1118959007864 substrate binding site [chemical binding]; other site 1118959007865 zinc binding site [ion binding]; other site 1118959007866 catalytic residues [active] 1118959007867 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 1118959007868 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1118959007869 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 1118959007870 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1118959007871 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1118959007872 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1118959007873 putative active site [active] 1118959007874 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1118959007875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1118959007876 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1118959007877 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1118959007878 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1118959007879 Walker A/P-loop; other site 1118959007880 ATP binding site [chemical binding]; other site 1118959007881 Q-loop/lid; other site 1118959007882 ABC transporter signature motif; other site 1118959007883 Walker B; other site 1118959007884 D-loop; other site 1118959007885 H-loop/switch region; other site 1118959007886 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1118959007887 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1118959007888 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1118959007889 Walker A/P-loop; other site 1118959007890 ATP binding site [chemical binding]; other site 1118959007891 Q-loop/lid; other site 1118959007892 ABC transporter signature motif; other site 1118959007893 Walker B; other site 1118959007894 D-loop; other site 1118959007895 H-loop/switch region; other site 1118959007896 hypothetical protein; Provisional; Region: PRK13661 1118959007897 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1118959007898 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1118959007899 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1118959007900 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1118959007901 Strictosidine synthase; Region: Str_synth; pfam03088 1118959007902 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1118959007903 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1118959007904 active site residue [active] 1118959007905 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1118959007906 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1118959007907 putative substrate binding pocket [chemical binding]; other site 1118959007908 AC domain interface; other site 1118959007909 catalytic triad [active] 1118959007910 AB domain interface; other site 1118959007911 interchain disulfide; other site 1118959007912 hypothetical protein; Validated; Region: PRK07668 1118959007913 Predicted transcriptional regulators [Transcription]; Region: COG1695 1118959007914 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1118959007915 DinB superfamily; Region: DinB_2; pfam12867 1118959007916 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1118959007917 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1118959007918 transmembrane helices; other site 1118959007919 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1118959007920 EamA-like transporter family; Region: EamA; pfam00892 1118959007921 hypothetical protein; Provisional; Region: PRK07758 1118959007922 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1118959007923 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1118959007924 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1118959007925 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1118959007926 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1118959007927 Walker A/P-loop; other site 1118959007928 ATP binding site [chemical binding]; other site 1118959007929 Q-loop/lid; other site 1118959007930 ABC transporter signature motif; other site 1118959007931 Walker B; other site 1118959007932 D-loop; other site 1118959007933 H-loop/switch region; other site 1118959007934 FtsX-like permease family; Region: FtsX; pfam02687 1118959007935 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1118959007936 Integrase core domain; Region: rve; pfam00665 1118959007937 Integrase core domain; Region: rve_3; cl15866 1118959007938 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1118959007939 Integrase core domain; Region: rve; pfam00665 1118959007940 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1118959007941 DNA-binding site [nucleotide binding]; DNA binding site 1118959007942 RNA-binding motif; other site 1118959007943 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1118959007944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1118959007945 non-specific DNA binding site [nucleotide binding]; other site 1118959007946 salt bridge; other site 1118959007947 sequence-specific DNA binding site [nucleotide binding]; other site 1118959007948 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1118959007949 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1118959007950 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1118959007951 ParB-like nuclease domain; Region: ParBc; pfam02195 1118959007952 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1118959007953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1118959007954 S-adenosylmethionine binding site [chemical binding]; other site 1118959007955 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1118959007956 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1118959007957 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1118959007958 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1118959007959 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1118959007960 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1118959007961 G1 box; other site 1118959007962 GTP/Mg2+ binding site [chemical binding]; other site 1118959007963 Switch I region; other site 1118959007964 G2 box; other site 1118959007965 Switch II region; other site 1118959007966 G3 box; other site 1118959007967 G4 box; other site 1118959007968 G5 box; other site 1118959007969 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1118959007970 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1118959007971 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399