-- dump date 20140620_074140 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1305598000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 1305598000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1305598000003 putative DNA binding surface [nucleotide binding]; other site 1305598000004 dimer interface [polypeptide binding]; other site 1305598000005 beta-clamp/clamp loader binding surface; other site 1305598000006 beta-clamp/translesion DNA polymerase binding surface; other site 1305598000007 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1305598000008 recF protein; Region: recf; TIGR00611 1305598000009 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1305598000010 Walker A/P-loop; other site 1305598000011 ATP binding site [chemical binding]; other site 1305598000012 Q-loop/lid; other site 1305598000013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598000014 ABC transporter signature motif; other site 1305598000015 Walker B; other site 1305598000016 D-loop; other site 1305598000017 H-loop/switch region; other site 1305598000018 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1305598000019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598000020 Mg2+ binding site [ion binding]; other site 1305598000021 G-X-G motif; other site 1305598000022 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1305598000023 anchoring element; other site 1305598000024 dimer interface [polypeptide binding]; other site 1305598000025 ATP binding site [chemical binding]; other site 1305598000026 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1305598000027 active site 1305598000028 putative metal-binding site [ion binding]; other site 1305598000029 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1305598000030 DNA gyrase subunit A; Validated; Region: PRK05560 1305598000031 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1305598000032 CAP-like domain; other site 1305598000033 active site 1305598000034 primary dimer interface [polypeptide binding]; other site 1305598000035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1305598000036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1305598000037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1305598000038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1305598000039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1305598000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1305598000041 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1305598000042 putative substrate binding site [chemical binding]; other site 1305598000043 putative ATP binding site [chemical binding]; other site 1305598000044 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1305598000045 active sites [active] 1305598000046 tetramer interface [polypeptide binding]; other site 1305598000047 seryl-tRNA synthetase; Provisional; Region: PRK05431 1305598000048 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1305598000049 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1305598000050 dimer interface [polypeptide binding]; other site 1305598000051 active site 1305598000052 motif 1; other site 1305598000053 motif 2; other site 1305598000054 motif 3; other site 1305598000055 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1305598000056 Predicted membrane protein [Function unknown]; Region: COG4392 1305598000057 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1305598000058 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1305598000059 Predicted membrane protein [Function unknown]; Region: COG4241 1305598000060 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1305598000061 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1305598000062 DHH family; Region: DHH; pfam01368 1305598000063 DHHA1 domain; Region: DHHA1; pfam02272 1305598000064 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1305598000065 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1305598000066 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1305598000067 replicative DNA helicase; Region: DnaB; TIGR00665 1305598000068 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1305598000069 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1305598000070 Walker A motif; other site 1305598000071 ATP binding site [chemical binding]; other site 1305598000072 Walker B motif; other site 1305598000073 DNA binding loops [nucleotide binding] 1305598000074 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1305598000075 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1305598000076 GDP-binding site [chemical binding]; other site 1305598000077 ACT binding site; other site 1305598000078 IMP binding site; other site 1305598000079 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1305598000080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598000081 active site 1305598000082 phosphorylation site [posttranslational modification] 1305598000083 intermolecular recognition site; other site 1305598000084 dimerization interface [polypeptide binding]; other site 1305598000085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1305598000086 DNA binding site [nucleotide binding] 1305598000087 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1305598000088 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1305598000089 dimerization interface [polypeptide binding]; other site 1305598000090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1305598000091 putative active site [active] 1305598000092 heme pocket [chemical binding]; other site 1305598000093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1305598000094 dimer interface [polypeptide binding]; other site 1305598000095 phosphorylation site [posttranslational modification] 1305598000096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598000097 ATP binding site [chemical binding]; other site 1305598000098 Mg2+ binding site [ion binding]; other site 1305598000099 G-X-G motif; other site 1305598000100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1305598000101 YycH protein; Region: YycH; pfam07435 1305598000102 YycH protein; Region: YycI; cl02015 1305598000103 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1305598000104 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1305598000105 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1305598000106 putative active site [active] 1305598000107 putative metal binding site [ion binding]; other site 1305598000108 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1305598000109 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1305598000110 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1305598000111 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1305598000112 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1305598000113 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1305598000114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598000115 Coenzyme A binding pocket [chemical binding]; other site 1305598000116 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1305598000117 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1305598000118 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1305598000119 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 1305598000120 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1305598000121 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1305598000122 catalytic residues [active] 1305598000123 catalytic nucleophile [active] 1305598000124 Recombinase; Region: Recombinase; pfam07508 1305598000125 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1305598000126 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1305598000127 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1305598000128 catalytic residues [active] 1305598000129 catalytic nucleophile [active] 1305598000130 Recombinase; Region: Recombinase; pfam07508 1305598000131 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1305598000132 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1305598000133 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1305598000134 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1305598000135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1305598000136 Helix-turn-helix domain; Region: HTH_28; pfam13518 1305598000137 HTH-like domain; Region: HTH_21; pfam13276 1305598000138 Integrase core domain; Region: rve; pfam00665 1305598000139 Integrase core domain; Region: rve_3; cl15866 1305598000140 carbamate kinase; Reviewed; Region: PRK12686 1305598000141 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1305598000142 putative substrate binding site [chemical binding]; other site 1305598000143 nucleotide binding site [chemical binding]; other site 1305598000144 nucleotide binding site [chemical binding]; other site 1305598000145 homodimer interface [polypeptide binding]; other site 1305598000146 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1305598000147 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1305598000148 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1305598000149 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1305598000150 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1305598000151 ligand binding site [chemical binding]; other site 1305598000152 flexible hinge region; other site 1305598000153 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1305598000154 putative switch regulator; other site 1305598000155 non-specific DNA interactions [nucleotide binding]; other site 1305598000156 DNA binding site [nucleotide binding] 1305598000157 sequence specific DNA binding site [nucleotide binding]; other site 1305598000158 putative cAMP binding site [chemical binding]; other site 1305598000159 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1305598000160 arginine deiminase; Provisional; Region: PRK01388 1305598000161 Arginine repressor [Transcription]; Region: ArgR; COG1438 1305598000162 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1305598000163 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1305598000164 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1305598000165 Ligand Binding Site [chemical binding]; other site 1305598000166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1305598000167 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 1305598000168 Integrase core domain; Region: rve; pfam00665 1305598000169 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1305598000170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1305598000171 non-specific DNA binding site [nucleotide binding]; other site 1305598000172 salt bridge; other site 1305598000173 sequence-specific DNA binding site [nucleotide binding]; other site 1305598000174 CAAX protease self-immunity; Region: Abi; pfam02517 1305598000175 Tic20-like protein; Region: Tic20; pfam09685 1305598000176 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1305598000177 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1305598000178 FMN binding site [chemical binding]; other site 1305598000179 substrate binding site [chemical binding]; other site 1305598000180 putative catalytic residue [active] 1305598000181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1305598000182 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1305598000183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1305598000184 Integrase core domain; Region: rve; pfam00665 1305598000185 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1305598000186 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1305598000187 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1305598000188 putative active site [active] 1305598000189 catalytic site [active] 1305598000190 putative metal binding site [ion binding]; other site 1305598000191 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1305598000192 putative active site [active] 1305598000193 putative catalytic site [active] 1305598000194 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1305598000195 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1305598000196 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1305598000197 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1305598000198 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1305598000199 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1305598000200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598000201 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1305598000202 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1305598000203 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1305598000204 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1305598000205 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 1305598000206 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1305598000207 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1305598000208 catalytic residues [active] 1305598000209 catalytic nucleophile [active] 1305598000210 Presynaptic Site I dimer interface [polypeptide binding]; other site 1305598000211 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1305598000212 Synaptic Flat tetramer interface [polypeptide binding]; other site 1305598000213 Synaptic Site I dimer interface [polypeptide binding]; other site 1305598000214 DNA binding site [nucleotide binding] 1305598000215 Recombinase; Region: Recombinase; pfam07508 1305598000216 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1305598000217 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 1305598000218 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1305598000219 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1305598000220 catalytic residues [active] 1305598000221 catalytic nucleophile [active] 1305598000222 Recombinase; Region: Recombinase; pfam07508 1305598000223 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1305598000224 Domain of unknown function (DUF927); Region: DUF927; pfam06048 1305598000225 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1305598000226 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1305598000227 Divergent AAA domain; Region: AAA_4; pfam04326 1305598000228 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1305598000229 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1305598000230 active site residue [active] 1305598000231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1305598000232 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1305598000233 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1305598000234 active site 1305598000235 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 1305598000236 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 1305598000237 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1305598000238 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1305598000239 phosphate binding site [ion binding]; other site 1305598000240 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1305598000241 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1305598000242 putative homodimer interface [polypeptide binding]; other site 1305598000243 putative homotetramer interface [polypeptide binding]; other site 1305598000244 putative metal binding site [ion binding]; other site 1305598000245 putative homodimer-homodimer interface [polypeptide binding]; other site 1305598000246 putative allosteric switch controlling residues; other site 1305598000247 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1305598000248 active site residue [active] 1305598000249 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 1305598000250 CPxP motif; other site 1305598000251 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1305598000252 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1305598000253 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1305598000254 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1305598000255 active site residue [active] 1305598000256 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1305598000257 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1305598000258 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1305598000259 FMN binding site [chemical binding]; other site 1305598000260 active site 1305598000261 catalytic residues [active] 1305598000262 substrate binding site [chemical binding]; other site 1305598000263 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1305598000264 H+ Antiporter protein; Region: 2A0121; TIGR00900 1305598000265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598000266 putative substrate translocation pore; other site 1305598000267 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1305598000268 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1305598000269 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1305598000270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1305598000271 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1305598000272 dimerization interface [polypeptide binding]; other site 1305598000273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1305598000274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1305598000275 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1305598000276 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1305598000277 Part of AAA domain; Region: AAA_19; pfam13245 1305598000278 AAA domain; Region: AAA_12; pfam13087 1305598000279 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1305598000280 active site 1305598000281 catalytic site [active] 1305598000282 putative metal binding site [ion binding]; other site 1305598000283 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598000284 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598000285 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598000286 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598000287 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1305598000288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1305598000289 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1305598000290 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1305598000291 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1305598000292 metal binding site [ion binding]; metal-binding site 1305598000293 dimer interface [polypeptide binding]; other site 1305598000294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598000295 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1305598000296 putative substrate translocation pore; other site 1305598000297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598000298 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1305598000299 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1305598000300 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1305598000301 PhoU domain; Region: PhoU; pfam01895 1305598000302 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1305598000303 EamA-like transporter family; Region: EamA; pfam00892 1305598000304 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1305598000305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1305598000306 DNA-binding site [nucleotide binding]; DNA binding site 1305598000307 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1305598000308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598000309 homodimer interface [polypeptide binding]; other site 1305598000310 catalytic residue [active] 1305598000311 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1305598000312 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1305598000313 L-lactate permease; Region: Lactate_perm; cl00701 1305598000314 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598000315 B domain; Region: B; pfam02216 1305598000316 B domain; Region: B; pfam02216 1305598000317 B domain; Region: B; pfam02216 1305598000318 B domain; Region: B; pfam02216 1305598000319 B domain; Region: B; pfam02216 1305598000320 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1305598000321 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598000322 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1305598000323 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598000324 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1305598000325 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1305598000326 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598000327 ABC-ATPase subunit interface; other site 1305598000328 dimer interface [polypeptide binding]; other site 1305598000329 putative PBP binding regions; other site 1305598000330 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1305598000331 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598000332 ABC-ATPase subunit interface; other site 1305598000333 dimer interface [polypeptide binding]; other site 1305598000334 putative PBP binding regions; other site 1305598000335 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1305598000336 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1305598000337 siderophore binding site; other site 1305598000338 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1305598000339 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1305598000340 dimer interface [polypeptide binding]; other site 1305598000341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598000342 catalytic residue [active] 1305598000343 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1305598000344 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1305598000345 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1305598000346 IucA / IucC family; Region: IucA_IucC; pfam04183 1305598000347 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1305598000348 drug efflux system protein MdtG; Provisional; Region: PRK09874 1305598000349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598000350 putative substrate translocation pore; other site 1305598000351 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1305598000352 IucA / IucC family; Region: IucA_IucC; pfam04183 1305598000353 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1305598000354 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1305598000355 IucA / IucC family; Region: IucA_IucC; pfam04183 1305598000356 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1305598000357 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1305598000358 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1305598000359 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1305598000360 dimer interface [polypeptide binding]; other site 1305598000361 active site 1305598000362 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1305598000363 catalytic residues [active] 1305598000364 substrate binding site [chemical binding]; other site 1305598000365 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1305598000366 ParB-like nuclease domain; Region: ParBc; pfam02195 1305598000367 acetoin reductase; Validated; Region: PRK08643 1305598000368 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1305598000369 NAD binding site [chemical binding]; other site 1305598000370 homotetramer interface [polypeptide binding]; other site 1305598000371 homodimer interface [polypeptide binding]; other site 1305598000372 active site 1305598000373 substrate binding site [chemical binding]; other site 1305598000374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1305598000375 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1305598000376 NAD(P) binding site [chemical binding]; other site 1305598000377 active site 1305598000378 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1305598000379 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1305598000380 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1305598000381 putative ADP-binding pocket [chemical binding]; other site 1305598000382 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1305598000383 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1305598000384 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1305598000385 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1305598000386 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1305598000387 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1305598000388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1305598000389 DNA-binding site [nucleotide binding]; DNA binding site 1305598000390 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1305598000391 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1305598000392 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1305598000393 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1305598000394 intersubunit interface [polypeptide binding]; other site 1305598000395 active site 1305598000396 catalytic residue [active] 1305598000397 phosphopentomutase; Provisional; Region: PRK05362 1305598000398 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1305598000399 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1305598000400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598000401 dimer interface [polypeptide binding]; other site 1305598000402 conserved gate region; other site 1305598000403 putative PBP binding loops; other site 1305598000404 ABC-ATPase subunit interface; other site 1305598000405 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1305598000406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598000407 dimer interface [polypeptide binding]; other site 1305598000408 conserved gate region; other site 1305598000409 ABC-ATPase subunit interface; other site 1305598000410 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1305598000411 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1305598000412 Walker A/P-loop; other site 1305598000413 ATP binding site [chemical binding]; other site 1305598000414 Q-loop/lid; other site 1305598000415 ABC transporter signature motif; other site 1305598000416 Walker B; other site 1305598000417 D-loop; other site 1305598000418 H-loop/switch region; other site 1305598000419 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1305598000420 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1305598000421 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1305598000422 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1305598000423 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1305598000424 active site 1305598000425 metal binding site [ion binding]; metal-binding site 1305598000426 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1305598000427 Replication initiation factor; Region: Rep_trans; pfam02486 1305598000428 Transposase IS200 like; Region: Y1_Tnp; cl00848 1305598000429 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1305598000430 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1305598000431 putative catalytic cysteine [active] 1305598000432 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1305598000433 putative active site [active] 1305598000434 metal binding site [ion binding]; metal-binding site 1305598000435 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1305598000436 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 1305598000437 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1305598000438 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1305598000439 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1305598000440 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1305598000441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1305598000442 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1305598000443 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1305598000444 NAD(P) binding site [chemical binding]; other site 1305598000445 homodimer interface [polypeptide binding]; other site 1305598000446 substrate binding site [chemical binding]; other site 1305598000447 active site 1305598000448 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1305598000449 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1305598000450 NAD(P) binding site [chemical binding]; other site 1305598000451 homodimer interface [polypeptide binding]; other site 1305598000452 substrate binding site [chemical binding]; other site 1305598000453 active site 1305598000454 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1305598000455 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1305598000456 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1305598000457 putative NAD(P) binding site [chemical binding]; other site 1305598000458 active site 1305598000459 putative substrate binding site [chemical binding]; other site 1305598000460 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1305598000461 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1305598000462 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1305598000463 active site 1305598000464 homodimer interface [polypeptide binding]; other site 1305598000465 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1305598000466 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1305598000467 trimer interface [polypeptide binding]; other site 1305598000468 active site 1305598000469 substrate binding site [chemical binding]; other site 1305598000470 CoA binding site [chemical binding]; other site 1305598000471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1305598000472 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1305598000473 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1305598000474 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1305598000475 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1305598000476 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1305598000477 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1305598000478 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1305598000479 putative NAD(P) binding site [chemical binding]; other site 1305598000480 active site 1305598000481 putative substrate binding site [chemical binding]; other site 1305598000482 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1305598000483 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1305598000484 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1305598000485 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1305598000486 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1305598000487 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1305598000488 active site 1305598000489 homodimer interface [polypeptide binding]; other site 1305598000490 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 1305598000491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1305598000492 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 1305598000493 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1305598000494 NAD(P) binding site [chemical binding]; other site 1305598000495 catalytic residues [active] 1305598000496 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1305598000497 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1305598000498 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1305598000499 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1305598000500 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1305598000501 Walker A/P-loop; other site 1305598000502 ATP binding site [chemical binding]; other site 1305598000503 Q-loop/lid; other site 1305598000504 ABC transporter signature motif; other site 1305598000505 Walker B; other site 1305598000506 D-loop; other site 1305598000507 H-loop/switch region; other site 1305598000508 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1305598000509 NMT1-like family; Region: NMT1_2; pfam13379 1305598000510 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1305598000511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1305598000512 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1305598000513 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1305598000514 active site 1305598000515 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1305598000516 formate dehydrogenase; Provisional; Region: PRK07574 1305598000517 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1305598000518 dimerization interface [polypeptide binding]; other site 1305598000519 ligand binding site [chemical binding]; other site 1305598000520 NAD binding site [chemical binding]; other site 1305598000521 catalytic site [active] 1305598000522 putative transporter; Provisional; Region: PRK10054 1305598000523 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1305598000524 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1305598000525 acyl-activating enzyme (AAE) consensus motif; other site 1305598000526 AMP binding site [chemical binding]; other site 1305598000527 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1305598000528 Condensation domain; Region: Condensation; pfam00668 1305598000529 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1305598000530 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1305598000531 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1305598000532 acyl-activating enzyme (AAE) consensus motif; other site 1305598000533 AMP binding site [chemical binding]; other site 1305598000534 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1305598000535 thioester reductase domain; Region: Thioester-redct; TIGR01746 1305598000536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1305598000537 NAD(P) binding site [chemical binding]; other site 1305598000538 active site 1305598000539 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1305598000540 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1305598000541 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1305598000542 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1305598000543 nucleotide binding site [chemical binding]; other site 1305598000544 N-acetyl-L-glutamate binding site [chemical binding]; other site 1305598000545 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1305598000546 heterotetramer interface [polypeptide binding]; other site 1305598000547 active site pocket [active] 1305598000548 cleavage site 1305598000549 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1305598000550 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1305598000551 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1305598000552 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1305598000553 inhibitor-cofactor binding pocket; inhibition site 1305598000554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598000555 catalytic residue [active] 1305598000556 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1305598000557 Isochorismatase family; Region: Isochorismatase; pfam00857 1305598000558 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1305598000559 catalytic triad [active] 1305598000560 conserved cis-peptide bond; other site 1305598000561 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1305598000562 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1305598000563 dimer interface [polypeptide binding]; other site 1305598000564 PYR/PP interface [polypeptide binding]; other site 1305598000565 TPP binding site [chemical binding]; other site 1305598000566 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1305598000567 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1305598000568 TPP-binding site [chemical binding]; other site 1305598000569 dimer interface [polypeptide binding]; other site 1305598000570 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1305598000571 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1305598000572 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1305598000573 active site turn [active] 1305598000574 phosphorylation site [posttranslational modification] 1305598000575 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1305598000576 HPr interaction site; other site 1305598000577 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1305598000578 active site 1305598000579 phosphorylation site [posttranslational modification] 1305598000580 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1305598000581 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1305598000582 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 1305598000583 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1305598000584 putative active site [active] 1305598000585 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1305598000586 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1305598000587 active site turn [active] 1305598000588 phosphorylation site [posttranslational modification] 1305598000589 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1305598000590 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1305598000591 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1305598000592 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1305598000593 putative active site [active] 1305598000594 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1305598000595 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1305598000596 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1305598000597 ATP binding site [chemical binding]; other site 1305598000598 putative Mg++ binding site [ion binding]; other site 1305598000599 RES domain; Region: RES; pfam08808 1305598000600 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1305598000601 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1305598000602 Walker A/P-loop; other site 1305598000603 ATP binding site [chemical binding]; other site 1305598000604 Q-loop/lid; other site 1305598000605 ABC transporter signature motif; other site 1305598000606 Walker B; other site 1305598000607 D-loop; other site 1305598000608 H-loop/switch region; other site 1305598000609 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1305598000610 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1305598000611 Walker A/P-loop; other site 1305598000612 ATP binding site [chemical binding]; other site 1305598000613 Q-loop/lid; other site 1305598000614 ABC transporter signature motif; other site 1305598000615 Walker B; other site 1305598000616 D-loop; other site 1305598000617 H-loop/switch region; other site 1305598000618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1305598000619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598000620 dimer interface [polypeptide binding]; other site 1305598000621 conserved gate region; other site 1305598000622 putative PBP binding loops; other site 1305598000623 ABC-ATPase subunit interface; other site 1305598000624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1305598000625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598000626 dimer interface [polypeptide binding]; other site 1305598000627 conserved gate region; other site 1305598000628 ABC-ATPase subunit interface; other site 1305598000629 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1305598000630 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1305598000631 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1305598000632 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1305598000633 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1305598000634 Protein of unknown function, DUF576; Region: DUF576; cl04553 1305598000635 azoreductase; Reviewed; Region: PRK00170 1305598000636 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1305598000637 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1305598000638 Peptidase family M23; Region: Peptidase_M23; pfam01551 1305598000639 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1305598000640 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1305598000641 Walker A/P-loop; other site 1305598000642 ATP binding site [chemical binding]; other site 1305598000643 Q-loop/lid; other site 1305598000644 ABC transporter signature motif; other site 1305598000645 Walker B; other site 1305598000646 D-loop; other site 1305598000647 H-loop/switch region; other site 1305598000648 TOBE domain; Region: TOBE; pfam03459 1305598000649 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1305598000650 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1305598000651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598000652 dimer interface [polypeptide binding]; other site 1305598000653 conserved gate region; other site 1305598000654 ABC-ATPase subunit interface; other site 1305598000655 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1305598000656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598000657 dimer interface [polypeptide binding]; other site 1305598000658 conserved gate region; other site 1305598000659 putative PBP binding loops; other site 1305598000660 ABC-ATPase subunit interface; other site 1305598000661 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1305598000662 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1305598000663 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1305598000664 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1305598000665 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1305598000666 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1305598000667 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1305598000668 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1305598000669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1305598000670 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1305598000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598000672 putative substrate translocation pore; other site 1305598000673 Response regulator receiver domain; Region: Response_reg; pfam00072 1305598000674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598000675 active site 1305598000676 phosphorylation site [posttranslational modification] 1305598000677 intermolecular recognition site; other site 1305598000678 dimerization interface [polypeptide binding]; other site 1305598000679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1305598000680 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1305598000681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1305598000682 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1305598000683 Histidine kinase; Region: His_kinase; pfam06580 1305598000684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598000685 ATP binding site [chemical binding]; other site 1305598000686 Mg2+ binding site [ion binding]; other site 1305598000687 G-X-G motif; other site 1305598000688 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1305598000689 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1305598000690 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1305598000691 Pyruvate formate lyase 1; Region: PFL1; cd01678 1305598000692 coenzyme A binding site [chemical binding]; other site 1305598000693 active site 1305598000694 catalytic residues [active] 1305598000695 glycine loop; other site 1305598000696 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1305598000697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1305598000698 FeS/SAM binding site; other site 1305598000699 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1305598000700 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1305598000701 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1305598000702 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1305598000703 putative active site [active] 1305598000704 catalytic site [active] 1305598000705 putative metal binding site [ion binding]; other site 1305598000706 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1305598000707 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1305598000708 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1305598000709 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1305598000710 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1305598000711 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1305598000712 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1305598000713 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1305598000714 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1305598000715 dimer interface [polypeptide binding]; other site 1305598000716 active site 1305598000717 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1305598000718 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1305598000719 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1305598000720 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1305598000721 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1305598000722 substrate binding site [chemical binding]; other site 1305598000723 oxyanion hole (OAH) forming residues; other site 1305598000724 trimer interface [polypeptide binding]; other site 1305598000725 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1305598000726 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1305598000727 active site 1305598000728 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1305598000729 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1305598000730 acyl-activating enzyme (AAE) consensus motif; other site 1305598000731 AMP binding site [chemical binding]; other site 1305598000732 active site 1305598000733 CoA binding site [chemical binding]; other site 1305598000734 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1305598000735 Coenzyme A transferase; Region: CoA_trans; smart00882 1305598000736 Coenzyme A transferase; Region: CoA_trans; cl17247 1305598000737 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1305598000738 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1305598000739 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1305598000740 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1305598000741 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1305598000742 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1305598000743 heme-binding site [chemical binding]; other site 1305598000744 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1305598000745 FAD binding pocket [chemical binding]; other site 1305598000746 FAD binding motif [chemical binding]; other site 1305598000747 phosphate binding motif [ion binding]; other site 1305598000748 beta-alpha-beta structure motif; other site 1305598000749 NAD binding pocket [chemical binding]; other site 1305598000750 Heme binding pocket [chemical binding]; other site 1305598000751 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1305598000752 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1305598000753 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1305598000754 NAD binding site [chemical binding]; other site 1305598000755 dimer interface [polypeptide binding]; other site 1305598000756 substrate binding site [chemical binding]; other site 1305598000757 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1305598000758 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1305598000759 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1305598000760 active site turn [active] 1305598000761 phosphorylation site [posttranslational modification] 1305598000762 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1305598000763 active site 1305598000764 tetramer interface [polypeptide binding]; other site 1305598000765 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1305598000766 Mga helix-turn-helix domain; Region: Mga; pfam05043 1305598000767 PRD domain; Region: PRD; pfam00874 1305598000768 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1305598000769 active site 1305598000770 P-loop; other site 1305598000771 phosphorylation site [posttranslational modification] 1305598000772 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1305598000773 active site 1305598000774 phosphorylation site [posttranslational modification] 1305598000775 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1305598000776 active site 1305598000777 phosphorylation site [posttranslational modification] 1305598000778 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1305598000779 active site 1305598000780 P-loop; other site 1305598000781 phosphorylation site [posttranslational modification] 1305598000782 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1305598000783 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1305598000784 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1305598000785 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1305598000786 putative NAD(P) binding site [chemical binding]; other site 1305598000787 catalytic Zn binding site [ion binding]; other site 1305598000788 structural Zn binding site [ion binding]; other site 1305598000789 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1305598000790 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1305598000791 putative NAD(P) binding site [chemical binding]; other site 1305598000792 catalytic Zn binding site [ion binding]; other site 1305598000793 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1305598000794 substrate binding site; other site 1305598000795 dimer interface; other site 1305598000796 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1305598000797 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1305598000798 putative NAD(P) binding site [chemical binding]; other site 1305598000799 putative catalytic Zn binding site [ion binding]; other site 1305598000800 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1305598000801 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1305598000802 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1305598000803 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1305598000804 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1305598000805 substrate binding site; other site 1305598000806 dimer interface; other site 1305598000807 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1305598000808 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1305598000809 putative NAD(P) binding site [chemical binding]; other site 1305598000810 putative catalytic Zn binding site [ion binding]; other site 1305598000811 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1305598000812 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1305598000813 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1305598000814 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1305598000815 active site 1305598000816 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 1305598000817 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1305598000818 Hemerythrin-like domain; Region: Hr-like; cd12108 1305598000819 Fe binding site [ion binding]; other site 1305598000820 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1305598000821 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1305598000822 Histidine kinase; Region: His_kinase; pfam06580 1305598000823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598000824 Mg2+ binding site [ion binding]; other site 1305598000825 G-X-G motif; other site 1305598000826 two-component response regulator; Provisional; Region: PRK14084 1305598000827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598000828 active site 1305598000829 phosphorylation site [posttranslational modification] 1305598000830 intermolecular recognition site; other site 1305598000831 dimerization interface [polypeptide binding]; other site 1305598000832 LytTr DNA-binding domain; Region: LytTR; pfam04397 1305598000833 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1305598000834 antiholin-like protein LrgB; Provisional; Region: PRK04288 1305598000835 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1305598000836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1305598000837 DNA-binding site [nucleotide binding]; DNA binding site 1305598000838 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1305598000839 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1305598000840 active site turn [active] 1305598000841 phosphorylation site [posttranslational modification] 1305598000842 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1305598000843 HPr interaction site; other site 1305598000844 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1305598000845 active site 1305598000846 phosphorylation site [posttranslational modification] 1305598000847 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1305598000848 beta-galactosidase; Region: BGL; TIGR03356 1305598000849 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1305598000850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598000851 S-adenosylmethionine binding site [chemical binding]; other site 1305598000852 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1305598000853 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1305598000854 substrate binding site [chemical binding]; other site 1305598000855 dimer interface [polypeptide binding]; other site 1305598000856 ATP binding site [chemical binding]; other site 1305598000857 D-ribose pyranase; Provisional; Region: PRK11797 1305598000858 Sugar transport protein; Region: Sugar_transport; pfam06800 1305598000859 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1305598000860 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1305598000861 DNA binding site [nucleotide binding] 1305598000862 domain linker motif; other site 1305598000863 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1305598000864 dimerization interface [polypeptide binding]; other site 1305598000865 ligand binding site [chemical binding]; other site 1305598000866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598000867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598000868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598000869 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1305598000870 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1305598000871 active site 1305598000872 Surface antigen [General function prediction only]; Region: COG3942 1305598000873 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1305598000874 Peptidase family M23; Region: Peptidase_M23; pfam01551 1305598000875 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1305598000876 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1305598000877 Walker A/P-loop; other site 1305598000878 ATP binding site [chemical binding]; other site 1305598000879 Q-loop/lid; other site 1305598000880 ABC transporter signature motif; other site 1305598000881 Walker B; other site 1305598000882 D-loop; other site 1305598000883 H-loop/switch region; other site 1305598000884 Surface antigen [General function prediction only]; Region: COG3942 1305598000885 CHAP domain; Region: CHAP; pfam05257 1305598000886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1305598000887 Predicted membrane protein [Function unknown]; Region: COG1511 1305598000888 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1305598000889 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1305598000890 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1305598000891 Uncharacterized small protein [Function unknown]; Region: COG5417 1305598000892 Predicted membrane protein [Function unknown]; Region: COG4499 1305598000893 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1305598000894 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1305598000895 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1305598000896 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1305598000897 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1305598000898 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1305598000899 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1305598000900 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1305598000901 Protein of unknown function, DUF600; Region: DUF600; cl04640 1305598000902 Protein of unknown function, DUF600; Region: DUF600; cl04640 1305598000903 Protein of unknown function, DUF600; Region: DUF600; cl04640 1305598000904 Protein of unknown function, DUF600; Region: DUF600; cl04640 1305598000905 Protein of unknown function, DUF600; Region: DUF600; cl04640 1305598000906 Protein of unknown function, DUF600; Region: DUF600; cl04640 1305598000907 Protein of unknown function, DUF600; Region: DUF600; cl04640 1305598000908 Protein of unknown function, DUF600; Region: DUF600; cl04640 1305598000909 Protein of unknown function, DUF600; Region: DUF600; cl04640 1305598000910 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 1305598000911 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1305598000912 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1305598000913 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1305598000914 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 1305598000915 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1305598000916 FtsX-like permease family; Region: FtsX; pfam02687 1305598000917 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1305598000918 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1305598000919 Walker A/P-loop; other site 1305598000920 ATP binding site [chemical binding]; other site 1305598000921 Q-loop/lid; other site 1305598000922 ABC transporter signature motif; other site 1305598000923 Walker B; other site 1305598000924 D-loop; other site 1305598000925 H-loop/switch region; other site 1305598000926 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1305598000927 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1305598000928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1305598000929 non-specific DNA binding site [nucleotide binding]; other site 1305598000930 salt bridge; other site 1305598000931 sequence-specific DNA binding site [nucleotide binding]; other site 1305598000932 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1305598000933 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1305598000934 substrate binding site [chemical binding]; other site 1305598000935 ATP binding site [chemical binding]; other site 1305598000936 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1305598000937 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1305598000938 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1305598000939 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1305598000940 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1305598000941 putative transporter; Provisional; Region: PRK10484 1305598000942 Na binding site [ion binding]; other site 1305598000943 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1305598000944 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1305598000945 inhibitor site; inhibition site 1305598000946 active site 1305598000947 dimer interface [polypeptide binding]; other site 1305598000948 catalytic residue [active] 1305598000949 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1305598000950 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1305598000951 nucleotide binding site [chemical binding]; other site 1305598000952 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1305598000953 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1305598000954 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1305598000955 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1305598000956 putative active site [active] 1305598000957 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1305598000958 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1305598000959 putative active site cavity [active] 1305598000960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1305598000961 Nucleoside recognition; Region: Gate; pfam07670 1305598000962 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1305598000963 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1305598000964 PGAP1-like protein; Region: PGAP1; pfam07819 1305598000965 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1305598000966 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1305598000967 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1305598000968 putative active site [active] 1305598000969 putative FMN binding site [chemical binding]; other site 1305598000970 putative substrate binding site [chemical binding]; other site 1305598000971 putative catalytic residue [active] 1305598000972 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1305598000973 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1305598000974 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1305598000975 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1305598000976 lipoyl attachment site [posttranslational modification]; other site 1305598000977 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1305598000978 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1305598000979 putative ADP-ribose binding site [chemical binding]; other site 1305598000980 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1305598000981 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1305598000982 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1305598000983 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1305598000984 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1305598000985 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1305598000986 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1305598000987 NADP binding site [chemical binding]; other site 1305598000988 putative substrate binding site [chemical binding]; other site 1305598000989 active site 1305598000990 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1305598000991 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1305598000992 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1305598000993 active site 1305598000994 phosphorylation site [posttranslational modification] 1305598000995 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1305598000996 HTH domain; Region: HTH_11; pfam08279 1305598000997 HTH domain; Region: HTH_11; pfam08279 1305598000998 PRD domain; Region: PRD; pfam00874 1305598000999 PRD domain; Region: PRD; pfam00874 1305598001000 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1305598001001 active site 1305598001002 P-loop; other site 1305598001003 phosphorylation site [posttranslational modification] 1305598001004 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1305598001005 active site 1305598001006 phosphorylation site [posttranslational modification] 1305598001007 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1305598001008 MarR family; Region: MarR_2; pfam12802 1305598001009 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1305598001010 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1305598001011 MepB protein; Region: MepB; cl01985 1305598001012 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1305598001013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598001014 putative substrate translocation pore; other site 1305598001015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598001016 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1305598001017 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1305598001018 Zn binding site [ion binding]; other site 1305598001019 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1305598001020 Zn binding site [ion binding]; other site 1305598001021 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1305598001022 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1305598001023 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1305598001024 Predicted flavoprotein [General function prediction only]; Region: COG0431 1305598001025 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1305598001026 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1305598001027 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1305598001028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1305598001029 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1305598001030 Imelysin; Region: Peptidase_M75; pfam09375 1305598001031 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1305598001032 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1305598001033 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1305598001034 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1305598001035 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1305598001036 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1305598001037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1305598001038 non-specific DNA binding site [nucleotide binding]; other site 1305598001039 salt bridge; other site 1305598001040 sequence-specific DNA binding site [nucleotide binding]; other site 1305598001041 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1305598001042 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1305598001043 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1305598001044 Walker A/P-loop; other site 1305598001045 ATP binding site [chemical binding]; other site 1305598001046 Q-loop/lid; other site 1305598001047 ABC transporter signature motif; other site 1305598001048 Walker B; other site 1305598001049 D-loop; other site 1305598001050 H-loop/switch region; other site 1305598001051 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1305598001052 Predicted membrane protein [Function unknown]; Region: COG4292 1305598001053 putative acyltransferase; Provisional; Region: PRK05790 1305598001054 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1305598001055 dimer interface [polypeptide binding]; other site 1305598001056 active site 1305598001057 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1305598001058 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1305598001059 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1305598001060 THF binding site; other site 1305598001061 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1305598001062 substrate binding site [chemical binding]; other site 1305598001063 THF binding site; other site 1305598001064 zinc-binding site [ion binding]; other site 1305598001065 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1305598001066 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1305598001067 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1305598001068 FAD binding site [chemical binding]; other site 1305598001069 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1305598001070 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1305598001071 homodimer interface [polypeptide binding]; other site 1305598001072 substrate-cofactor binding pocket; other site 1305598001073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598001074 catalytic residue [active] 1305598001075 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1305598001076 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1305598001077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1305598001078 catalytic residue [active] 1305598001079 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1305598001080 ParB-like nuclease domain; Region: ParB; smart00470 1305598001081 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1305598001082 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1305598001083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 1305598001084 GTP-binding protein YchF; Reviewed; Region: PRK09601 1305598001085 YchF GTPase; Region: YchF; cd01900 1305598001086 G1 box; other site 1305598001087 GTP/Mg2+ binding site [chemical binding]; other site 1305598001088 Switch I region; other site 1305598001089 G2 box; other site 1305598001090 Switch II region; other site 1305598001091 G3 box; other site 1305598001092 G4 box; other site 1305598001093 G5 box; other site 1305598001094 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1305598001095 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1305598001096 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1305598001097 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1305598001098 dimer interface [polypeptide binding]; other site 1305598001099 ssDNA binding site [nucleotide binding]; other site 1305598001100 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1305598001101 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1305598001102 Abi-like protein; Region: Abi_2; pfam07751 1305598001103 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1305598001104 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1305598001105 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001106 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1305598001107 Predicted membrane protein [Function unknown]; Region: COG3212 1305598001108 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1305598001109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1305598001110 non-specific DNA binding site [nucleotide binding]; other site 1305598001111 salt bridge; other site 1305598001112 sequence-specific DNA binding site [nucleotide binding]; other site 1305598001113 Predicted membrane protein [Function unknown]; Region: COG2261 1305598001114 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1305598001115 catalytic core [active] 1305598001116 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1305598001117 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1305598001118 catalytic residue [active] 1305598001119 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1305598001120 catalytic residues [active] 1305598001121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1305598001122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598001123 peroxiredoxin; Region: AhpC; TIGR03137 1305598001124 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1305598001125 dimer interface [polypeptide binding]; other site 1305598001126 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1305598001127 catalytic triad [active] 1305598001128 peroxidatic and resolving cysteines [active] 1305598001129 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1305598001130 dimer interface [polypeptide binding]; other site 1305598001131 FMN binding site [chemical binding]; other site 1305598001132 NADPH bind site [chemical binding]; other site 1305598001133 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1305598001134 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1305598001135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1305598001136 active site 1305598001137 xanthine permease; Region: pbuX; TIGR03173 1305598001138 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1305598001139 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1305598001140 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1305598001141 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1305598001142 active site 1305598001143 GMP synthase; Reviewed; Region: guaA; PRK00074 1305598001144 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1305598001145 AMP/PPi binding site [chemical binding]; other site 1305598001146 candidate oxyanion hole; other site 1305598001147 catalytic triad [active] 1305598001148 potential glutamine specificity residues [chemical binding]; other site 1305598001149 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1305598001150 ATP Binding subdomain [chemical binding]; other site 1305598001151 Ligand Binding sites [chemical binding]; other site 1305598001152 Dimerization subdomain; other site 1305598001153 PemK-like protein; Region: PemK; pfam02452 1305598001154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1305598001155 Transposase; Region: HTH_Tnp_1; cl17663 1305598001156 Predicted membrane protein [Function unknown]; Region: COG3759 1305598001157 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1305598001158 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1305598001159 NADP binding site [chemical binding]; other site 1305598001160 superantigen-like protein; Reviewed; Region: PRK13037 1305598001161 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001162 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001163 superantigen-like protein; Reviewed; Region: PRK13041 1305598001164 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001165 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001166 superantigen-like protein; Reviewed; Region: PRK13335 1305598001167 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001168 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001169 superantigen-like protein; Reviewed; Region: PRK13042 1305598001170 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001171 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001172 superantigen-like protein 5; Reviewed; Region: PRK13035 1305598001173 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001174 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001175 superantigen-like protein; Reviewed; Region: PRK13040 1305598001176 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001177 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001178 superantigen-like protein 7; Reviewed; Region: PRK13346 1305598001179 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001180 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001181 superantigen-like protein; Reviewed; Region: PRK13039 1305598001182 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001183 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001184 superantigen-like protein; Reviewed; Region: PRK13345 1305598001185 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001186 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001187 superantigen-like protein 5; Reviewed; Region: PRK13035 1305598001188 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001189 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001190 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1305598001191 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1305598001192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598001193 S-adenosylmethionine binding site [chemical binding]; other site 1305598001194 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1305598001195 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1305598001196 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1305598001197 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1305598001198 superantigen-like protein; Reviewed; Region: PRK13036 1305598001199 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1305598001200 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598001201 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598001202 Protein of unknown function, DUF576; Region: DUF576; cl04553 1305598001203 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598001204 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598001205 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598001206 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598001207 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598001208 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598001209 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598001210 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1305598001211 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1305598001212 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1305598001213 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1305598001214 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1305598001215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1305598001216 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1305598001217 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1305598001218 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1305598001219 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1305598001220 active site 1305598001221 Esterase/lipase [General function prediction only]; Region: COG1647 1305598001222 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1305598001223 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1305598001224 Na2 binding site [ion binding]; other site 1305598001225 putative substrate binding site 1 [chemical binding]; other site 1305598001226 Na binding site 1 [ion binding]; other site 1305598001227 putative substrate binding site 2 [chemical binding]; other site 1305598001228 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1305598001229 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1305598001230 dimer interface [polypeptide binding]; other site 1305598001231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598001232 catalytic residue [active] 1305598001233 cystathionine beta-lyase; Provisional; Region: PRK07671 1305598001234 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1305598001235 homodimer interface [polypeptide binding]; other site 1305598001236 substrate-cofactor binding pocket; other site 1305598001237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598001238 catalytic residue [active] 1305598001239 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1305598001240 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1305598001241 Walker A/P-loop; other site 1305598001242 ATP binding site [chemical binding]; other site 1305598001243 Q-loop/lid; other site 1305598001244 ABC transporter signature motif; other site 1305598001245 Walker B; other site 1305598001246 D-loop; other site 1305598001247 H-loop/switch region; other site 1305598001248 NIL domain; Region: NIL; pfam09383 1305598001249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598001250 dimer interface [polypeptide binding]; other site 1305598001251 conserved gate region; other site 1305598001252 ABC-ATPase subunit interface; other site 1305598001253 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1305598001254 LysM domain; Region: LysM; pfam01476 1305598001255 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1305598001256 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1305598001257 Surface antigen [General function prediction only]; Region: COG3942 1305598001258 CHAP domain; Region: CHAP; pfam05257 1305598001259 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1305598001260 nudix motif; other site 1305598001261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598001262 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1305598001263 Coenzyme A binding pocket [chemical binding]; other site 1305598001264 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1305598001265 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1305598001266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1305598001267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1305598001268 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1305598001269 dimerization interface [polypeptide binding]; other site 1305598001270 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1305598001271 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1305598001272 active site 1305598001273 dimer interface [polypeptide binding]; other site 1305598001274 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1305598001275 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1305598001276 active site 1305598001277 FMN binding site [chemical binding]; other site 1305598001278 substrate binding site [chemical binding]; other site 1305598001279 3Fe-4S cluster binding site [ion binding]; other site 1305598001280 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1305598001281 domain interface; other site 1305598001282 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1305598001283 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1305598001284 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1305598001285 active site turn [active] 1305598001286 phosphorylation site [posttranslational modification] 1305598001287 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1305598001288 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1305598001289 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1305598001290 Ca binding site [ion binding]; other site 1305598001291 active site 1305598001292 catalytic site [active] 1305598001293 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1305598001294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1305598001295 DNA-binding site [nucleotide binding]; DNA binding site 1305598001296 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1305598001297 UTRA domain; Region: UTRA; pfam07702 1305598001298 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1305598001299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598001300 Coenzyme A binding pocket [chemical binding]; other site 1305598001301 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1305598001302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598001303 Walker A motif; other site 1305598001304 ATP binding site [chemical binding]; other site 1305598001305 Walker B motif; other site 1305598001306 arginine finger; other site 1305598001307 hypothetical protein; Validated; Region: PRK00153 1305598001308 recombination protein RecR; Reviewed; Region: recR; PRK00076 1305598001309 RecR protein; Region: RecR; pfam02132 1305598001310 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1305598001311 putative active site [active] 1305598001312 putative metal-binding site [ion binding]; other site 1305598001313 tetramer interface [polypeptide binding]; other site 1305598001314 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1305598001315 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1305598001316 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1305598001317 catalytic residue [active] 1305598001318 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1305598001319 thymidylate kinase; Validated; Region: tmk; PRK00698 1305598001320 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1305598001321 TMP-binding site; other site 1305598001322 ATP-binding site [chemical binding]; other site 1305598001323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1305598001324 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1305598001325 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1305598001326 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1305598001327 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1305598001328 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1305598001329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598001330 S-adenosylmethionine binding site [chemical binding]; other site 1305598001331 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1305598001332 GIY-YIG motif/motif A; other site 1305598001333 putative active site [active] 1305598001334 putative metal binding site [ion binding]; other site 1305598001335 Predicted methyltransferases [General function prediction only]; Region: COG0313 1305598001336 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1305598001337 putative SAM binding site [chemical binding]; other site 1305598001338 putative homodimer interface [polypeptide binding]; other site 1305598001339 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1305598001340 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1305598001341 active site 1305598001342 HIGH motif; other site 1305598001343 KMSKS motif; other site 1305598001344 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1305598001345 tRNA binding surface [nucleotide binding]; other site 1305598001346 anticodon binding site; other site 1305598001347 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1305598001348 dimer interface [polypeptide binding]; other site 1305598001349 putative tRNA-binding site [nucleotide binding]; other site 1305598001350 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1305598001351 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1305598001352 active site 1305598001353 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1305598001354 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1305598001355 putative active site [active] 1305598001356 putative metal binding site [ion binding]; other site 1305598001357 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1305598001358 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1305598001359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598001360 S-adenosylmethionine binding site [chemical binding]; other site 1305598001361 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1305598001362 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1305598001363 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1305598001364 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1305598001365 pur operon repressor; Provisional; Region: PRK09213 1305598001366 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1305598001367 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1305598001368 active site 1305598001369 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1305598001370 homotrimer interaction site [polypeptide binding]; other site 1305598001371 putative active site [active] 1305598001372 regulatory protein SpoVG; Reviewed; Region: PRK13259 1305598001373 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1305598001374 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1305598001375 Substrate binding site; other site 1305598001376 Mg++ binding site; other site 1305598001377 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1305598001378 active site 1305598001379 substrate binding site [chemical binding]; other site 1305598001380 CoA binding site [chemical binding]; other site 1305598001381 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1305598001382 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1305598001383 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1305598001384 active site 1305598001385 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1305598001386 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1305598001387 5S rRNA interface [nucleotide binding]; other site 1305598001388 CTC domain interface [polypeptide binding]; other site 1305598001389 L16 interface [polypeptide binding]; other site 1305598001390 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1305598001391 putative active site [active] 1305598001392 catalytic residue [active] 1305598001393 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1305598001394 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1305598001395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1305598001396 ATP binding site [chemical binding]; other site 1305598001397 putative Mg++ binding site [ion binding]; other site 1305598001398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1305598001399 nucleotide binding region [chemical binding]; other site 1305598001400 ATP-binding site [chemical binding]; other site 1305598001401 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1305598001402 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1305598001403 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1305598001404 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1305598001405 putative SAM binding site [chemical binding]; other site 1305598001406 putative homodimer interface [polypeptide binding]; other site 1305598001407 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1305598001408 homodimer interface [polypeptide binding]; other site 1305598001409 metal binding site [ion binding]; metal-binding site 1305598001410 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1305598001411 RNA binding surface [nucleotide binding]; other site 1305598001412 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1305598001413 Septum formation initiator; Region: DivIC; pfam04977 1305598001414 hypothetical protein; Provisional; Region: PRK08582 1305598001415 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1305598001416 RNA binding site [nucleotide binding]; other site 1305598001417 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1305598001418 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1305598001419 Ligand Binding Site [chemical binding]; other site 1305598001420 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1305598001421 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1305598001422 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1305598001423 active site 1305598001424 FtsH Extracellular; Region: FtsH_ext; pfam06480 1305598001425 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1305598001426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598001427 Walker A motif; other site 1305598001428 ATP binding site [chemical binding]; other site 1305598001429 Walker B motif; other site 1305598001430 arginine finger; other site 1305598001431 Peptidase family M41; Region: Peptidase_M41; pfam01434 1305598001432 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1305598001433 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1305598001434 dimerization interface [polypeptide binding]; other site 1305598001435 domain crossover interface; other site 1305598001436 redox-dependent activation switch; other site 1305598001437 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1305598001438 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1305598001439 dimer interface [polypeptide binding]; other site 1305598001440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598001441 catalytic residue [active] 1305598001442 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1305598001443 dihydropteroate synthase; Region: DHPS; TIGR01496 1305598001444 substrate binding pocket [chemical binding]; other site 1305598001445 dimer interface [polypeptide binding]; other site 1305598001446 inhibitor binding site; inhibition site 1305598001447 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1305598001448 homooctamer interface [polypeptide binding]; other site 1305598001449 active site 1305598001450 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1305598001451 catalytic center binding site [active] 1305598001452 ATP binding site [chemical binding]; other site 1305598001453 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1305598001454 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1305598001455 dimer interface [polypeptide binding]; other site 1305598001456 putative anticodon binding site; other site 1305598001457 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1305598001458 motif 1; other site 1305598001459 active site 1305598001460 motif 2; other site 1305598001461 motif 3; other site 1305598001462 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1305598001463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1305598001464 DNA-binding site [nucleotide binding]; DNA binding site 1305598001465 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1305598001466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598001467 homodimer interface [polypeptide binding]; other site 1305598001468 catalytic residue [active] 1305598001469 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1305598001470 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1305598001471 active site 1305598001472 multimer interface [polypeptide binding]; other site 1305598001473 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1305598001474 predicted active site [active] 1305598001475 catalytic triad [active] 1305598001476 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1305598001477 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1305598001478 Nucleoside recognition; Region: Gate; pfam07670 1305598001479 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1305598001480 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1305598001481 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1305598001482 UvrB/uvrC motif; Region: UVR; pfam02151 1305598001483 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1305598001484 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1305598001485 ADP binding site [chemical binding]; other site 1305598001486 phosphagen binding site; other site 1305598001487 substrate specificity loop; other site 1305598001488 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1305598001489 Clp amino terminal domain; Region: Clp_N; pfam02861 1305598001490 Clp amino terminal domain; Region: Clp_N; pfam02861 1305598001491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598001492 Walker A motif; other site 1305598001493 ATP binding site [chemical binding]; other site 1305598001494 Walker B motif; other site 1305598001495 arginine finger; other site 1305598001496 UvrB/uvrC motif; Region: UVR; pfam02151 1305598001497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598001498 Walker A motif; other site 1305598001499 ATP binding site [chemical binding]; other site 1305598001500 Walker B motif; other site 1305598001501 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1305598001502 DNA repair protein RadA; Provisional; Region: PRK11823 1305598001503 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1305598001504 Walker A motif/ATP binding site; other site 1305598001505 ATP binding site [chemical binding]; other site 1305598001506 Walker B motif; other site 1305598001507 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1305598001508 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1305598001509 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1305598001510 putative active site [active] 1305598001511 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1305598001512 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1305598001513 active site 1305598001514 HIGH motif; other site 1305598001515 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1305598001516 active site 1305598001517 KMSKS motif; other site 1305598001518 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1305598001519 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1305598001520 trimer interface [polypeptide binding]; other site 1305598001521 active site 1305598001522 substrate binding site [chemical binding]; other site 1305598001523 CoA binding site [chemical binding]; other site 1305598001524 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1305598001525 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1305598001526 active site 1305598001527 HIGH motif; other site 1305598001528 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1305598001529 KMSKS motif; other site 1305598001530 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1305598001531 tRNA binding surface [nucleotide binding]; other site 1305598001532 anticodon binding site; other site 1305598001533 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1305598001534 active site 1305598001535 dimerization interface [polypeptide binding]; other site 1305598001536 metal binding site [ion binding]; metal-binding site 1305598001537 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1305598001538 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1305598001539 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1305598001540 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1305598001541 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1305598001542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1305598001543 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1305598001544 DNA binding residues [nucleotide binding] 1305598001545 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1305598001546 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1305598001547 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1305598001548 putative homodimer interface [polypeptide binding]; other site 1305598001549 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1305598001550 heterodimer interface [polypeptide binding]; other site 1305598001551 homodimer interface [polypeptide binding]; other site 1305598001552 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1305598001553 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1305598001554 23S rRNA interface [nucleotide binding]; other site 1305598001555 L7/L12 interface [polypeptide binding]; other site 1305598001556 putative thiostrepton binding site; other site 1305598001557 L25 interface [polypeptide binding]; other site 1305598001558 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1305598001559 mRNA/rRNA interface [nucleotide binding]; other site 1305598001560 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1305598001561 23S rRNA interface [nucleotide binding]; other site 1305598001562 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1305598001563 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1305598001564 peripheral dimer interface [polypeptide binding]; other site 1305598001565 core dimer interface [polypeptide binding]; other site 1305598001566 L10 interface [polypeptide binding]; other site 1305598001567 L11 interface [polypeptide binding]; other site 1305598001568 putative EF-Tu interaction site [polypeptide binding]; other site 1305598001569 putative EF-G interaction site [polypeptide binding]; other site 1305598001570 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1305598001571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598001572 S-adenosylmethionine binding site [chemical binding]; other site 1305598001573 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1305598001574 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1305598001575 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1305598001576 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1305598001577 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1305598001578 RPB10 interaction site [polypeptide binding]; other site 1305598001579 RPB1 interaction site [polypeptide binding]; other site 1305598001580 RPB11 interaction site [polypeptide binding]; other site 1305598001581 RPB3 interaction site [polypeptide binding]; other site 1305598001582 RPB12 interaction site [polypeptide binding]; other site 1305598001583 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1305598001584 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1305598001585 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1305598001586 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1305598001587 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1305598001588 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1305598001589 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1305598001590 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1305598001591 G-loop; other site 1305598001592 DNA binding site [nucleotide binding] 1305598001593 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 1305598001594 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1305598001595 S17 interaction site [polypeptide binding]; other site 1305598001596 S8 interaction site; other site 1305598001597 16S rRNA interaction site [nucleotide binding]; other site 1305598001598 streptomycin interaction site [chemical binding]; other site 1305598001599 23S rRNA interaction site [nucleotide binding]; other site 1305598001600 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1305598001601 30S ribosomal protein S7; Validated; Region: PRK05302 1305598001602 elongation factor G; Reviewed; Region: PRK00007 1305598001603 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1305598001604 G1 box; other site 1305598001605 putative GEF interaction site [polypeptide binding]; other site 1305598001606 GTP/Mg2+ binding site [chemical binding]; other site 1305598001607 Switch I region; other site 1305598001608 G2 box; other site 1305598001609 G3 box; other site 1305598001610 Switch II region; other site 1305598001611 G4 box; other site 1305598001612 G5 box; other site 1305598001613 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1305598001614 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1305598001615 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1305598001616 elongation factor Tu; Reviewed; Region: PRK00049 1305598001617 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1305598001618 G1 box; other site 1305598001619 GEF interaction site [polypeptide binding]; other site 1305598001620 GTP/Mg2+ binding site [chemical binding]; other site 1305598001621 Switch I region; other site 1305598001622 G2 box; other site 1305598001623 G3 box; other site 1305598001624 Switch II region; other site 1305598001625 G4 box; other site 1305598001626 G5 box; other site 1305598001627 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1305598001628 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1305598001629 Antibiotic Binding Site [chemical binding]; other site 1305598001630 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1305598001631 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1305598001632 metal binding site [ion binding]; metal-binding site 1305598001633 dimer interface [polypeptide binding]; other site 1305598001634 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1305598001635 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1305598001636 substrate-cofactor binding pocket; other site 1305598001637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598001638 catalytic residue [active] 1305598001639 chaperone protein HchA; Provisional; Region: PRK04155 1305598001640 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1305598001641 conserved cys residue [active] 1305598001642 ribulokinase; Provisional; Region: PRK04123 1305598001643 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1305598001644 N- and C-terminal domain interface [polypeptide binding]; other site 1305598001645 active site 1305598001646 MgATP binding site [chemical binding]; other site 1305598001647 catalytic site [active] 1305598001648 metal binding site [ion binding]; metal-binding site 1305598001649 carbohydrate binding site [chemical binding]; other site 1305598001650 homodimer interface [polypeptide binding]; other site 1305598001651 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1305598001652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1305598001653 NAD(P) binding site [chemical binding]; other site 1305598001654 active site 1305598001655 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1305598001656 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1305598001657 homodimer interface [polypeptide binding]; other site 1305598001658 substrate-cofactor binding pocket; other site 1305598001659 catalytic residue [active] 1305598001660 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1305598001661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598001662 motif II; other site 1305598001663 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1305598001664 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1305598001665 Substrate-binding site [chemical binding]; other site 1305598001666 Substrate specificity [chemical binding]; other site 1305598001667 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1305598001668 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1305598001669 Substrate-binding site [chemical binding]; other site 1305598001670 Substrate specificity [chemical binding]; other site 1305598001671 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1305598001672 nucleoside/Zn binding site; other site 1305598001673 dimer interface [polypeptide binding]; other site 1305598001674 catalytic motif [active] 1305598001675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598001676 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1305598001677 active site 1305598001678 motif I; other site 1305598001679 motif II; other site 1305598001680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598001681 Predicted flavoprotein [General function prediction only]; Region: COG0431 1305598001682 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1305598001683 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598001684 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1305598001685 Cna protein B-type domain; Region: Cna_B; pfam05738 1305598001686 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1305598001687 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598001688 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1305598001689 Cna protein B-type domain; Region: Cna_B; pfam05738 1305598001690 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1305598001691 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1305598001692 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1305598001693 Cna protein B-type domain; Region: Cna_B; pfam05738 1305598001694 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598001695 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1305598001696 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1305598001697 Cna protein B-type domain; Region: Cna_B; pfam05738 1305598001698 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1305598001699 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1305598001700 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1305598001701 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1305598001702 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1305598001703 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1305598001704 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1305598001705 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1305598001706 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1305598001707 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1305598001708 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1305598001709 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1305598001710 active site 1305598001711 trimer interface [polypeptide binding]; other site 1305598001712 allosteric site; other site 1305598001713 active site lid [active] 1305598001714 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1305598001715 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1305598001716 active site 1305598001717 dimer interface [polypeptide binding]; other site 1305598001718 magnesium binding site [ion binding]; other site 1305598001719 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1305598001720 tetramer interface [polypeptide binding]; other site 1305598001721 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1305598001722 active site 1305598001723 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1305598001724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598001725 motif II; other site 1305598001726 proline/glycine betaine transporter; Provisional; Region: PRK10642 1305598001727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598001728 putative substrate translocation pore; other site 1305598001729 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1305598001730 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1305598001731 acyl-activating enzyme (AAE) consensus motif; other site 1305598001732 AMP binding site [chemical binding]; other site 1305598001733 active site 1305598001734 CoA binding site [chemical binding]; other site 1305598001735 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1305598001736 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1305598001737 dimer interface [polypeptide binding]; other site 1305598001738 active site 1305598001739 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1305598001740 dimer interface [polypeptide binding]; other site 1305598001741 substrate binding site [chemical binding]; other site 1305598001742 ATP binding site [chemical binding]; other site 1305598001743 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1305598001744 ligand binding site [chemical binding]; other site 1305598001745 active site 1305598001746 UGI interface [polypeptide binding]; other site 1305598001747 catalytic site [active] 1305598001748 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1305598001749 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1305598001750 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1305598001751 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1305598001752 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1305598001753 putative heme peroxidase; Provisional; Region: PRK12276 1305598001754 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1305598001755 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1305598001756 mevalonate kinase; Region: mevalon_kin; TIGR00549 1305598001757 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1305598001758 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1305598001759 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1305598001760 diphosphomevalonate decarboxylase; Region: PLN02407 1305598001761 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1305598001762 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1305598001763 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1305598001764 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1305598001765 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1305598001766 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1305598001767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598001768 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1305598001769 Predicted transcriptional regulator [Transcription]; Region: COG1959 1305598001770 Transcriptional regulator; Region: Rrf2; pfam02082 1305598001771 LXG domain of WXG superfamily; Region: LXG; pfam04740 1305598001772 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1305598001773 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1305598001774 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1305598001775 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1305598001776 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1305598001777 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1305598001778 Protein of unknown function (DUF443); Region: DUF443; cl04467 1305598001779 Protein of unknown function (DUF443); Region: DUF443; cl04467 1305598001780 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1305598001781 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1305598001782 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1305598001783 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1305598001784 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1305598001785 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1305598001786 active site 1305598001787 catalytic tetrad [active] 1305598001788 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1305598001789 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1305598001790 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1305598001791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598001792 Coenzyme A binding pocket [chemical binding]; other site 1305598001793 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1305598001794 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1305598001795 Zn2+ binding site [ion binding]; other site 1305598001796 Mg2+ binding site [ion binding]; other site 1305598001797 YwhD family; Region: YwhD; pfam08741 1305598001798 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1305598001799 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1305598001800 NAD binding site [chemical binding]; other site 1305598001801 substrate binding site [chemical binding]; other site 1305598001802 catalytic Zn binding site [ion binding]; other site 1305598001803 tetramer interface [polypeptide binding]; other site 1305598001804 structural Zn binding site [ion binding]; other site 1305598001805 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1305598001806 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1305598001807 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1305598001808 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1305598001809 active site 1305598001810 HIGH motif; other site 1305598001811 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1305598001812 KMSK motif region; other site 1305598001813 tRNA binding surface [nucleotide binding]; other site 1305598001814 DALR anticodon binding domain; Region: DALR_1; smart00836 1305598001815 anticodon binding site; other site 1305598001816 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1305598001817 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1305598001818 minor groove reading motif; other site 1305598001819 helix-hairpin-helix signature motif; other site 1305598001820 substrate binding pocket [chemical binding]; other site 1305598001821 active site 1305598001822 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1305598001823 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1305598001824 putative binding site residues; other site 1305598001825 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1305598001826 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598001827 ABC-ATPase subunit interface; other site 1305598001828 dimer interface [polypeptide binding]; other site 1305598001829 putative PBP binding regions; other site 1305598001830 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1305598001831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598001832 motif II; other site 1305598001833 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1305598001834 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1305598001835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1305598001836 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1305598001837 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598001838 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1305598001839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1305598001840 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1305598001841 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1305598001842 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1305598001843 active site 1305598001844 DNA binding site [nucleotide binding] 1305598001845 Int/Topo IB signature motif; other site 1305598001846 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 1305598001847 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1305598001848 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1305598001849 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 1305598001850 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1305598001851 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1305598001852 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1305598001853 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1305598001854 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1305598001855 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1305598001856 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1305598001857 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1305598001858 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1305598001859 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1305598001860 metal binding site [ion binding]; metal-binding site 1305598001861 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1305598001862 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598001863 ABC-ATPase subunit interface; other site 1305598001864 dimer interface [polypeptide binding]; other site 1305598001865 putative PBP binding regions; other site 1305598001866 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1305598001867 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1305598001868 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1305598001869 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1305598001870 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1305598001871 FeoA domain; Region: FeoA; pfam04023 1305598001872 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1305598001873 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1305598001874 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1305598001875 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1305598001876 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1305598001877 Walker A/P-loop; other site 1305598001878 ATP binding site [chemical binding]; other site 1305598001879 Q-loop/lid; other site 1305598001880 ABC transporter signature motif; other site 1305598001881 Walker B; other site 1305598001882 D-loop; other site 1305598001883 H-loop/switch region; other site 1305598001884 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1305598001885 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1305598001886 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1305598001887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1305598001888 active site 1305598001889 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1305598001890 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1305598001891 active site 1305598001892 nucleotide binding site [chemical binding]; other site 1305598001893 HIGH motif; other site 1305598001894 KMSKS motif; other site 1305598001895 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1305598001896 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1305598001897 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1305598001898 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1305598001899 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1305598001900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598001901 Walker A/P-loop; other site 1305598001902 ATP binding site [chemical binding]; other site 1305598001903 Q-loop/lid; other site 1305598001904 ABC transporter signature motif; other site 1305598001905 Walker B; other site 1305598001906 D-loop; other site 1305598001907 H-loop/switch region; other site 1305598001908 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1305598001909 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1305598001910 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1305598001911 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1305598001912 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1305598001913 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1305598001914 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1305598001915 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1305598001916 Walker A/P-loop; other site 1305598001917 ATP binding site [chemical binding]; other site 1305598001918 Q-loop/lid; other site 1305598001919 ABC transporter signature motif; other site 1305598001920 Walker B; other site 1305598001921 D-loop; other site 1305598001922 H-loop/switch region; other site 1305598001923 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1305598001924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598001925 ABC-ATPase subunit interface; other site 1305598001926 dimer interface [polypeptide binding]; other site 1305598001927 putative PBP binding regions; other site 1305598001928 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1305598001929 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598001930 ABC-ATPase subunit interface; other site 1305598001931 dimer interface [polypeptide binding]; other site 1305598001932 putative PBP binding regions; other site 1305598001933 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1305598001934 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1305598001935 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1305598001936 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1305598001937 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1305598001938 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1305598001939 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1305598001940 Na binding site [ion binding]; other site 1305598001941 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1305598001942 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1305598001943 substrate binding pocket [chemical binding]; other site 1305598001944 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1305598001945 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1305598001946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598001947 Coenzyme A binding pocket [chemical binding]; other site 1305598001948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1305598001949 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1305598001950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1305598001951 NAD(P) binding site [chemical binding]; other site 1305598001952 active site 1305598001953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1305598001954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598001955 active site 1305598001956 phosphorylation site [posttranslational modification] 1305598001957 intermolecular recognition site; other site 1305598001958 dimerization interface [polypeptide binding]; other site 1305598001959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1305598001960 DNA binding site [nucleotide binding] 1305598001961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1305598001962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1305598001963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598001964 ATP binding site [chemical binding]; other site 1305598001965 Mg2+ binding site [ion binding]; other site 1305598001966 G-X-G motif; other site 1305598001967 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1305598001968 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1305598001969 Walker A/P-loop; other site 1305598001970 ATP binding site [chemical binding]; other site 1305598001971 Q-loop/lid; other site 1305598001972 ABC transporter signature motif; other site 1305598001973 Walker B; other site 1305598001974 D-loop; other site 1305598001975 H-loop/switch region; other site 1305598001976 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1305598001977 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1305598001978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1305598001979 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1305598001980 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1305598001981 Surface antigen [General function prediction only]; Region: COG3942 1305598001982 CHAP domain; Region: CHAP; pfam05257 1305598001983 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1305598001984 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1305598001985 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1305598001986 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598001987 hypothetical protein; Provisional; Region: PRK12378 1305598001988 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1305598001989 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1305598001990 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1305598001991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1305598001992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1305598001993 dimerization interface [polypeptide binding]; other site 1305598001994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598001995 sugar efflux transporter; Region: 2A0120; TIGR00899 1305598001996 putative substrate translocation pore; other site 1305598001997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1305598001998 Serine incorporator (Serinc); Region: Serinc; pfam03348 1305598001999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598002000 Coenzyme A binding pocket [chemical binding]; other site 1305598002001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1305598002002 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1305598002003 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1305598002004 hypothetical protein; Validated; Region: PRK00124 1305598002005 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1305598002006 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1305598002007 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1305598002008 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1305598002009 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1305598002010 Walker A/P-loop; other site 1305598002011 ATP binding site [chemical binding]; other site 1305598002012 Q-loop/lid; other site 1305598002013 ABC transporter signature motif; other site 1305598002014 Walker B; other site 1305598002015 D-loop; other site 1305598002016 H-loop/switch region; other site 1305598002017 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1305598002018 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1305598002019 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1305598002020 Walker A/P-loop; other site 1305598002021 ATP binding site [chemical binding]; other site 1305598002022 Q-loop/lid; other site 1305598002023 ABC transporter signature motif; other site 1305598002024 Walker B; other site 1305598002025 D-loop; other site 1305598002026 H-loop/switch region; other site 1305598002027 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1305598002028 MarR family; Region: MarR; pfam01047 1305598002029 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1305598002030 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1305598002031 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1305598002032 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1305598002033 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1305598002034 active site 1305598002035 catalytic tetrad [active] 1305598002036 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1305598002037 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1305598002038 transmembrane helices; other site 1305598002039 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1305598002040 DNA photolyase; Region: DNA_photolyase; pfam00875 1305598002041 Predicted membrane protein [Function unknown]; Region: COG4330 1305598002042 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1305598002043 trimer interface [polypeptide binding]; other site 1305598002044 putative Zn binding site [ion binding]; other site 1305598002045 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1305598002046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598002047 putative substrate translocation pore; other site 1305598002048 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1305598002049 putative deacylase active site [active] 1305598002050 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1305598002051 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1305598002052 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1305598002053 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1305598002054 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1305598002055 putative substrate binding site [chemical binding]; other site 1305598002056 putative ATP binding site [chemical binding]; other site 1305598002057 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1305598002058 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1305598002059 active site 1305598002060 phosphorylation site [posttranslational modification] 1305598002061 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1305598002062 active site 1305598002063 P-loop; other site 1305598002064 phosphorylation site [posttranslational modification] 1305598002065 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1305598002066 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1305598002067 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1305598002068 active site 1305598002069 dimer interface [polypeptide binding]; other site 1305598002070 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1305598002071 Domain of unknown function DUF21; Region: DUF21; pfam01595 1305598002072 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1305598002073 Transporter associated domain; Region: CorC_HlyC; pfam03471 1305598002074 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1305598002075 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1305598002076 active site 1305598002077 catalytic tetrad [active] 1305598002078 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1305598002079 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1305598002080 Ligand binding site; other site 1305598002081 Putative Catalytic site; other site 1305598002082 DXD motif; other site 1305598002083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1305598002084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1305598002085 dimer interface [polypeptide binding]; other site 1305598002086 phosphorylation site [posttranslational modification] 1305598002087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598002088 ATP binding site [chemical binding]; other site 1305598002089 Mg2+ binding site [ion binding]; other site 1305598002090 G-X-G motif; other site 1305598002091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1305598002092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598002093 active site 1305598002094 phosphorylation site [posttranslational modification] 1305598002095 intermolecular recognition site; other site 1305598002096 dimerization interface [polypeptide binding]; other site 1305598002097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1305598002098 DNA binding site [nucleotide binding] 1305598002099 DoxX; Region: DoxX; pfam07681 1305598002100 Electron transfer DM13; Region: DM13; pfam10517 1305598002101 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1305598002102 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1305598002103 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1305598002104 active site 1305598002105 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1305598002106 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1305598002107 Ligand Binding Site [chemical binding]; other site 1305598002108 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1305598002109 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1305598002110 glutamine binding [chemical binding]; other site 1305598002111 catalytic triad [active] 1305598002112 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1305598002113 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1305598002114 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1305598002115 substrate-cofactor binding pocket; other site 1305598002116 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1305598002117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598002118 catalytic residue [active] 1305598002119 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1305598002120 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1305598002121 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1305598002122 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1305598002123 Sulfatase; Region: Sulfatase; pfam00884 1305598002124 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1305598002125 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1305598002126 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1305598002127 ABC transporter; Region: ABC_tran_2; pfam12848 1305598002128 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1305598002129 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1305598002130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1305598002131 ATP binding site [chemical binding]; other site 1305598002132 putative Mg++ binding site [ion binding]; other site 1305598002133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1305598002134 nucleotide binding region [chemical binding]; other site 1305598002135 ATP-binding site [chemical binding]; other site 1305598002136 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1305598002137 HRDC domain; Region: HRDC; pfam00570 1305598002138 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1305598002139 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1305598002140 Walker A/P-loop; other site 1305598002141 ATP binding site [chemical binding]; other site 1305598002142 Q-loop/lid; other site 1305598002143 ABC transporter signature motif; other site 1305598002144 Walker B; other site 1305598002145 D-loop; other site 1305598002146 H-loop/switch region; other site 1305598002147 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1305598002148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598002149 dimer interface [polypeptide binding]; other site 1305598002150 conserved gate region; other site 1305598002151 ABC-ATPase subunit interface; other site 1305598002152 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1305598002153 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1305598002154 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1305598002155 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1305598002156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598002157 homodimer interface [polypeptide binding]; other site 1305598002158 catalytic residue [active] 1305598002159 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1305598002160 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1305598002161 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1305598002162 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1305598002163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598002164 putative substrate translocation pore; other site 1305598002165 POT family; Region: PTR2; cl17359 1305598002166 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1305598002167 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1305598002168 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1305598002169 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1305598002170 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1305598002171 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1305598002172 active site 1305598002173 dimer interface [polypeptide binding]; other site 1305598002174 catalytic residues [active] 1305598002175 effector binding site; other site 1305598002176 R2 peptide binding site; other site 1305598002177 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1305598002178 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1305598002179 dimer interface [polypeptide binding]; other site 1305598002180 putative radical transfer pathway; other site 1305598002181 diiron center [ion binding]; other site 1305598002182 tyrosyl radical; other site 1305598002183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598002184 ABC-ATPase subunit interface; other site 1305598002185 dimer interface [polypeptide binding]; other site 1305598002186 putative PBP binding regions; other site 1305598002187 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598002188 ABC-ATPase subunit interface; other site 1305598002189 dimer interface [polypeptide binding]; other site 1305598002190 putative PBP binding regions; other site 1305598002191 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1305598002192 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1305598002193 Walker A/P-loop; other site 1305598002194 ATP binding site [chemical binding]; other site 1305598002195 Q-loop/lid; other site 1305598002196 ABC transporter signature motif; other site 1305598002197 Walker B; other site 1305598002198 D-loop; other site 1305598002199 H-loop/switch region; other site 1305598002200 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1305598002201 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1305598002202 putative ligand binding residues [chemical binding]; other site 1305598002203 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1305598002204 CHY zinc finger; Region: zf-CHY; pfam05495 1305598002205 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1305598002206 FAD binding domain; Region: FAD_binding_4; pfam01565 1305598002207 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1305598002208 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1305598002209 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1305598002210 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1305598002211 peptidase T; Region: peptidase-T; TIGR01882 1305598002212 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1305598002213 metal binding site [ion binding]; metal-binding site 1305598002214 dimer interface [polypeptide binding]; other site 1305598002215 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1305598002216 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1305598002217 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1305598002218 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1305598002219 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1305598002220 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1305598002221 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1305598002222 metal binding site [ion binding]; metal-binding site 1305598002223 active site 1305598002224 I-site; other site 1305598002225 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1305598002226 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1305598002227 Mg++ binding site [ion binding]; other site 1305598002228 putative catalytic motif [active] 1305598002229 substrate binding site [chemical binding]; other site 1305598002230 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1305598002231 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1305598002232 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1305598002233 EDD domain protein, DegV family; Region: DegV; TIGR00762 1305598002234 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1305598002235 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1305598002236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1305598002237 ATP binding site [chemical binding]; other site 1305598002238 putative Mg++ binding site [ion binding]; other site 1305598002239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1305598002240 nucleotide binding region [chemical binding]; other site 1305598002241 ATP-binding site [chemical binding]; other site 1305598002242 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1305598002243 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1305598002244 active site 1305598002245 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1305598002246 30S subunit binding site; other site 1305598002247 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1305598002248 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1305598002249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1305598002250 nucleotide binding region [chemical binding]; other site 1305598002251 ATP-binding site [chemical binding]; other site 1305598002252 SEC-C motif; Region: SEC-C; pfam02810 1305598002253 peptide chain release factor 2; Provisional; Region: PRK06746 1305598002254 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1305598002255 RF-1 domain; Region: RF-1; pfam00472 1305598002256 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1305598002257 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1305598002258 Surface antigen [General function prediction only]; Region: COG3942 1305598002259 CHAP domain; Region: CHAP; pfam05257 1305598002260 HD domain; Region: HD_3; cl17350 1305598002261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 1305598002262 excinuclease ABC subunit B; Provisional; Region: PRK05298 1305598002263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1305598002264 ATP binding site [chemical binding]; other site 1305598002265 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1305598002266 nucleotide binding region [chemical binding]; other site 1305598002267 ATP-binding site [chemical binding]; other site 1305598002268 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1305598002269 UvrB/uvrC motif; Region: UVR; pfam02151 1305598002270 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1305598002271 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1305598002272 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1305598002273 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1305598002274 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1305598002275 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1305598002276 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1305598002277 Hpr binding site; other site 1305598002278 active site 1305598002279 homohexamer subunit interaction site [polypeptide binding]; other site 1305598002280 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1305598002281 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1305598002282 putative trimer interface [polypeptide binding]; other site 1305598002283 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1305598002284 putative CoA binding site [chemical binding]; other site 1305598002285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1305598002286 binding surface 1305598002287 TPR motif; other site 1305598002288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1305598002289 TPR motif; other site 1305598002290 binding surface 1305598002291 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1305598002292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1305598002293 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598002294 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1305598002295 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1305598002296 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1305598002297 phosphate binding site [ion binding]; other site 1305598002298 dimer interface [polypeptide binding]; other site 1305598002299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1305598002300 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1305598002301 Clp protease; Region: CLP_protease; pfam00574 1305598002302 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1305598002303 oligomer interface [polypeptide binding]; other site 1305598002304 active site residues [active] 1305598002305 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1305598002306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1305598002307 NAD(P) binding site [chemical binding]; other site 1305598002308 active site 1305598002309 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1305598002310 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1305598002311 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1305598002312 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1305598002313 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1305598002314 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1305598002315 Phosphoglycerate kinase; Region: PGK; pfam00162 1305598002316 substrate binding site [chemical binding]; other site 1305598002317 hinge regions; other site 1305598002318 ADP binding site [chemical binding]; other site 1305598002319 catalytic site [active] 1305598002320 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1305598002321 triosephosphate isomerase; Provisional; Region: PRK14565 1305598002322 substrate binding site [chemical binding]; other site 1305598002323 dimer interface [polypeptide binding]; other site 1305598002324 catalytic triad [active] 1305598002325 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1305598002326 phosphoglyceromutase; Provisional; Region: PRK05434 1305598002327 enolase; Provisional; Region: eno; PRK00077 1305598002328 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1305598002329 dimer interface [polypeptide binding]; other site 1305598002330 metal binding site [ion binding]; metal-binding site 1305598002331 substrate binding pocket [chemical binding]; other site 1305598002332 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1305598002333 Esterase/lipase [General function prediction only]; Region: COG1647 1305598002334 Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735 1305598002335 ribonuclease R; Region: RNase_R; TIGR02063 1305598002336 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1305598002337 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1305598002338 RNB domain; Region: RNB; pfam00773 1305598002339 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1305598002340 RNA binding site [nucleotide binding]; other site 1305598002341 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1305598002342 SmpB-tmRNA interface; other site 1305598002343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598002344 Coenzyme A binding pocket [chemical binding]; other site 1305598002345 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598002346 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1305598002347 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1305598002348 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1305598002349 Staphylococcal nuclease homologues; Region: SNc; smart00318 1305598002350 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1305598002351 Catalytic site; other site 1305598002352 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1305598002353 DNA-binding site [nucleotide binding]; DNA binding site 1305598002354 RNA-binding motif; other site 1305598002355 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1305598002356 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1305598002357 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1305598002358 catalytic core [active] 1305598002359 Lysine efflux permease [General function prediction only]; Region: COG1279 1305598002360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1305598002361 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1305598002362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1305598002363 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1305598002364 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1305598002365 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1305598002366 active site 1305598002367 catalytic residue [active] 1305598002368 dimer interface [polypeptide binding]; other site 1305598002369 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1305598002370 putative FMN binding site [chemical binding]; other site 1305598002371 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1305598002372 catalytic residues [active] 1305598002373 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1305598002374 ArsC family; Region: ArsC; pfam03960 1305598002375 putative ArsC-like catalytic residues; other site 1305598002376 putative TRX-like catalytic residues [active] 1305598002377 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1305598002378 lipoyl attachment site [posttranslational modification]; other site 1305598002379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1305598002380 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1305598002381 putative active site [active] 1305598002382 putative metal binding site [ion binding]; other site 1305598002383 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1305598002384 catalytic residues [active] 1305598002385 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1305598002386 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1305598002387 Walker A/P-loop; other site 1305598002388 ATP binding site [chemical binding]; other site 1305598002389 Q-loop/lid; other site 1305598002390 ABC transporter signature motif; other site 1305598002391 Walker B; other site 1305598002392 D-loop; other site 1305598002393 H-loop/switch region; other site 1305598002394 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1305598002395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598002396 dimer interface [polypeptide binding]; other site 1305598002397 conserved gate region; other site 1305598002398 ABC-ATPase subunit interface; other site 1305598002399 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1305598002400 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1305598002401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1305598002402 Predicted membrane protein [Function unknown]; Region: COG2035 1305598002403 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1305598002404 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1305598002405 Walker A/P-loop; other site 1305598002406 ATP binding site [chemical binding]; other site 1305598002407 Q-loop/lid; other site 1305598002408 ABC transporter signature motif; other site 1305598002409 Walker B; other site 1305598002410 D-loop; other site 1305598002411 H-loop/switch region; other site 1305598002412 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1305598002413 FeS assembly protein SufD; Region: sufD; TIGR01981 1305598002414 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1305598002415 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1305598002416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1305598002417 catalytic residue [active] 1305598002418 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1305598002419 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1305598002420 trimerization site [polypeptide binding]; other site 1305598002421 active site 1305598002422 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1305598002423 FeS assembly protein SufB; Region: sufB; TIGR01980 1305598002424 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1305598002425 Domain of unknown function DUF21; Region: DUF21; pfam01595 1305598002426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1305598002427 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1305598002428 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1305598002429 FMN binding site [chemical binding]; other site 1305598002430 substrate binding site [chemical binding]; other site 1305598002431 putative catalytic residue [active] 1305598002432 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1305598002433 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1305598002434 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1305598002435 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1305598002436 active site 1305598002437 metal binding site [ion binding]; metal-binding site 1305598002438 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1305598002439 lipoyl synthase; Provisional; Region: PRK05481 1305598002440 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1305598002441 FeS/SAM binding site; other site 1305598002442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1305598002443 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1305598002444 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1305598002445 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1305598002446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598002447 active site 1305598002448 motif I; other site 1305598002449 motif II; other site 1305598002450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598002451 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1305598002452 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1305598002453 dimerization interface [polypeptide binding]; other site 1305598002454 ligand binding site [chemical binding]; other site 1305598002455 NADP binding site [chemical binding]; other site 1305598002456 catalytic site [active] 1305598002457 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1305598002458 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1305598002459 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1305598002460 acyl-activating enzyme (AAE) consensus motif; other site 1305598002461 AMP binding site [chemical binding]; other site 1305598002462 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1305598002463 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1305598002464 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1305598002465 DltD N-terminal region; Region: DltD_N; pfam04915 1305598002466 DltD central region; Region: DltD_M; pfam04918 1305598002467 DltD C-terminal region; Region: DltD_C; pfam04914 1305598002468 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1305598002469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1305598002470 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1305598002471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598002472 hypothetical protein; Provisional; Region: PRK13669 1305598002473 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1305598002474 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1305598002475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598002476 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1305598002477 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1305598002478 interface (dimer of trimers) [polypeptide binding]; other site 1305598002479 Substrate-binding/catalytic site; other site 1305598002480 Zn-binding sites [ion binding]; other site 1305598002481 Predicted permease [General function prediction only]; Region: COG2056 1305598002482 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1305598002483 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1305598002484 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1305598002485 CoenzymeA binding site [chemical binding]; other site 1305598002486 subunit interaction site [polypeptide binding]; other site 1305598002487 PHB binding site; other site 1305598002488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1305598002489 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1305598002490 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1305598002491 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1305598002492 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 1305598002493 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1305598002494 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1305598002495 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1305598002496 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1305598002497 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1305598002498 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1305598002499 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1305598002500 Kinase associated protein B; Region: KapB; pfam08810 1305598002501 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1305598002502 active site 1305598002503 general stress protein 13; Validated; Region: PRK08059 1305598002504 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1305598002505 RNA binding site [nucleotide binding]; other site 1305598002506 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1305598002507 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1305598002508 putative active site [active] 1305598002509 putative FMN binding site [chemical binding]; other site 1305598002510 putative substrate binding site [chemical binding]; other site 1305598002511 putative catalytic residue [active] 1305598002512 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1305598002513 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1305598002514 inhibitor-cofactor binding pocket; inhibition site 1305598002515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598002516 catalytic residue [active] 1305598002517 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1305598002518 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1305598002519 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1305598002520 NAD(P) binding site [chemical binding]; other site 1305598002521 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1305598002522 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1305598002523 active site 1305598002524 catalytic site [active] 1305598002525 metal binding site [ion binding]; metal-binding site 1305598002526 argininosuccinate lyase; Provisional; Region: PRK00855 1305598002527 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1305598002528 active sites [active] 1305598002529 tetramer interface [polypeptide binding]; other site 1305598002530 argininosuccinate synthase; Provisional; Region: PRK13820 1305598002531 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1305598002532 ANP binding site [chemical binding]; other site 1305598002533 Substrate Binding Site II [chemical binding]; other site 1305598002534 Substrate Binding Site I [chemical binding]; other site 1305598002535 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1305598002536 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1305598002537 active site 1305598002538 dimer interface [polypeptide binding]; other site 1305598002539 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1305598002540 dimer interface [polypeptide binding]; other site 1305598002541 active site 1305598002542 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1305598002543 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1305598002544 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1305598002545 Catalytic site [active] 1305598002546 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1305598002547 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1305598002548 Catalytic site [active] 1305598002549 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1305598002550 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1305598002551 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1305598002552 Part of AAA domain; Region: AAA_19; pfam13245 1305598002553 Family description; Region: UvrD_C_2; pfam13538 1305598002554 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1305598002555 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1305598002556 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1305598002557 hypothetical protein; Provisional; Region: PRK13673 1305598002558 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1305598002559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1305598002560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598002561 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1305598002562 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1305598002563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598002564 active site 1305598002565 motif I; other site 1305598002566 motif II; other site 1305598002567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598002568 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1305598002569 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1305598002570 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1305598002571 catalytic triad [active] 1305598002572 catalytic triad [active] 1305598002573 oxyanion hole [active] 1305598002574 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1305598002575 Clp amino terminal domain; Region: Clp_N; pfam02861 1305598002576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598002577 Walker A motif; other site 1305598002578 ATP binding site [chemical binding]; other site 1305598002579 Walker B motif; other site 1305598002580 arginine finger; other site 1305598002581 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1305598002582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598002583 Walker A motif; other site 1305598002584 ATP binding site [chemical binding]; other site 1305598002585 Walker B motif; other site 1305598002586 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1305598002587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1305598002588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1305598002589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1305598002590 dimerization interface [polypeptide binding]; other site 1305598002591 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1305598002592 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1305598002593 active site 1305598002594 catalytic residues [active] 1305598002595 metal binding site [ion binding]; metal-binding site 1305598002596 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1305598002597 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1305598002598 substrate binding site [chemical binding]; other site 1305598002599 MAP domain; Region: MAP; pfam03642 1305598002600 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1305598002601 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1305598002602 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1305598002603 dimer interface [polypeptide binding]; other site 1305598002604 active site 1305598002605 CoA binding pocket [chemical binding]; other site 1305598002606 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1305598002607 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1305598002608 dimer interface [polypeptide binding]; other site 1305598002609 active site 1305598002610 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1305598002611 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1305598002612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598002613 dimer interface [polypeptide binding]; other site 1305598002614 conserved gate region; other site 1305598002615 putative PBP binding loops; other site 1305598002616 ABC-ATPase subunit interface; other site 1305598002617 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1305598002618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598002619 dimer interface [polypeptide binding]; other site 1305598002620 conserved gate region; other site 1305598002621 putative PBP binding loops; other site 1305598002622 ABC-ATPase subunit interface; other site 1305598002623 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1305598002624 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1305598002625 Walker A/P-loop; other site 1305598002626 ATP binding site [chemical binding]; other site 1305598002627 Q-loop/lid; other site 1305598002628 ABC transporter signature motif; other site 1305598002629 Walker B; other site 1305598002630 D-loop; other site 1305598002631 H-loop/switch region; other site 1305598002632 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1305598002633 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1305598002634 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1305598002635 Walker A/P-loop; other site 1305598002636 ATP binding site [chemical binding]; other site 1305598002637 Q-loop/lid; other site 1305598002638 ABC transporter signature motif; other site 1305598002639 Walker B; other site 1305598002640 D-loop; other site 1305598002641 H-loop/switch region; other site 1305598002642 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1305598002643 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1305598002644 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1305598002645 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1305598002646 peptide binding site [polypeptide binding]; other site 1305598002647 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1305598002648 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1305598002649 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1305598002650 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1305598002651 Walker A/P-loop; other site 1305598002652 ATP binding site [chemical binding]; other site 1305598002653 Q-loop/lid; other site 1305598002654 ABC transporter signature motif; other site 1305598002655 Walker B; other site 1305598002656 D-loop; other site 1305598002657 H-loop/switch region; other site 1305598002658 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1305598002659 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1305598002660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1305598002661 Walker A/P-loop; other site 1305598002662 ATP binding site [chemical binding]; other site 1305598002663 Q-loop/lid; other site 1305598002664 ABC transporter signature motif; other site 1305598002665 Walker B; other site 1305598002666 D-loop; other site 1305598002667 H-loop/switch region; other site 1305598002668 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1305598002669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1305598002670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598002671 dimer interface [polypeptide binding]; other site 1305598002672 conserved gate region; other site 1305598002673 putative PBP binding loops; other site 1305598002674 ABC-ATPase subunit interface; other site 1305598002675 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1305598002676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598002677 dimer interface [polypeptide binding]; other site 1305598002678 conserved gate region; other site 1305598002679 putative PBP binding loops; other site 1305598002680 ABC-ATPase subunit interface; other site 1305598002681 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1305598002682 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1305598002683 active site 1305598002684 HIGH motif; other site 1305598002685 dimer interface [polypeptide binding]; other site 1305598002686 KMSKS motif; other site 1305598002687 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1305598002688 ArsC family; Region: ArsC; pfam03960 1305598002689 putative catalytic residues [active] 1305598002690 thiol/disulfide switch; other site 1305598002691 adaptor protein; Provisional; Region: PRK02315 1305598002692 Competence protein CoiA-like family; Region: CoiA; cl11541 1305598002693 Competence protein CoiA-like family; Region: CoiA; cl11541 1305598002694 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1305598002695 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1305598002696 active site 1305598002697 Zn binding site [ion binding]; other site 1305598002698 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1305598002699 Thioredoxin; Region: Thioredoxin_5; pfam13743 1305598002700 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1305598002701 apolar tunnel; other site 1305598002702 heme binding site [chemical binding]; other site 1305598002703 dimerization interface [polypeptide binding]; other site 1305598002704 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1305598002705 putative active site [active] 1305598002706 putative metal binding residues [ion binding]; other site 1305598002707 signature motif; other site 1305598002708 putative triphosphate binding site [ion binding]; other site 1305598002709 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1305598002710 synthetase active site [active] 1305598002711 NTP binding site [chemical binding]; other site 1305598002712 metal binding site [ion binding]; metal-binding site 1305598002713 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1305598002714 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1305598002715 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1305598002716 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1305598002717 active site 1305598002718 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1305598002719 MgtE intracellular N domain; Region: MgtE_N; smart00924 1305598002720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1305598002721 Divalent cation transporter; Region: MgtE; pfam01769 1305598002722 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1305598002723 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1305598002724 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1305598002725 TrkA-N domain; Region: TrkA_N; pfam02254 1305598002726 TrkA-C domain; Region: TrkA_C; pfam02080 1305598002727 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1305598002728 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1305598002729 NAD binding site [chemical binding]; other site 1305598002730 homotetramer interface [polypeptide binding]; other site 1305598002731 homodimer interface [polypeptide binding]; other site 1305598002732 substrate binding site [chemical binding]; other site 1305598002733 active site 1305598002734 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1305598002735 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1305598002736 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1305598002737 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1305598002738 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1305598002739 Putative esterase; Region: Esterase; pfam00756 1305598002740 hypothetical protein; Provisional; Region: PRK13679 1305598002741 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1305598002742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598002743 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1305598002744 putative substrate translocation pore; other site 1305598002745 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1305598002746 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1305598002747 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1305598002748 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1305598002749 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1305598002750 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1305598002751 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1305598002752 YueH-like protein; Region: YueH; pfam14166 1305598002753 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1305598002754 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1305598002755 G1 box; other site 1305598002756 putative GEF interaction site [polypeptide binding]; other site 1305598002757 GTP/Mg2+ binding site [chemical binding]; other site 1305598002758 Switch I region; other site 1305598002759 G2 box; other site 1305598002760 G3 box; other site 1305598002761 Switch II region; other site 1305598002762 G4 box; other site 1305598002763 G5 box; other site 1305598002764 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1305598002765 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1305598002766 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1305598002767 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1305598002768 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1305598002769 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1305598002770 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1305598002771 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1305598002772 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1305598002773 active site 1305598002774 metal binding site [ion binding]; metal-binding site 1305598002775 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1305598002776 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1305598002777 IDEAL domain; Region: IDEAL; pfam08858 1305598002778 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1305598002779 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1305598002780 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1305598002781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1305598002782 CAAX protease self-immunity; Region: Abi; pfam02517 1305598002783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1305598002784 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1305598002785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1305598002786 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1305598002787 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1305598002788 Walker A/P-loop; other site 1305598002789 ATP binding site [chemical binding]; other site 1305598002790 Q-loop/lid; other site 1305598002791 ABC transporter signature motif; other site 1305598002792 Walker B; other site 1305598002793 D-loop; other site 1305598002794 H-loop/switch region; other site 1305598002795 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1305598002796 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1305598002797 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1305598002798 Predicted membrane protein [Function unknown]; Region: COG2259 1305598002799 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1305598002800 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1305598002801 siderophore binding site; other site 1305598002802 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1305598002803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598002804 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1305598002805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1305598002806 Coenzyme A binding pocket [chemical binding]; other site 1305598002807 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1305598002808 UbiA prenyltransferase family; Region: UbiA; pfam01040 1305598002809 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1305598002810 isochorismate synthases; Region: isochor_syn; TIGR00543 1305598002811 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1305598002812 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1305598002813 dimer interface [polypeptide binding]; other site 1305598002814 tetramer interface [polypeptide binding]; other site 1305598002815 PYR/PP interface [polypeptide binding]; other site 1305598002816 TPP binding site [chemical binding]; other site 1305598002817 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1305598002818 TPP-binding site; other site 1305598002819 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1305598002820 PGAP1-like protein; Region: PGAP1; pfam07819 1305598002821 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1305598002822 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1305598002823 substrate binding site [chemical binding]; other site 1305598002824 oxyanion hole (OAH) forming residues; other site 1305598002825 trimer interface [polypeptide binding]; other site 1305598002826 Staphostatin B; Region: Staphostatin_B; pfam09023 1305598002827 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1305598002828 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1305598002829 aminotransferase A; Validated; Region: PRK07683 1305598002830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1305598002831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598002832 homodimer interface [polypeptide binding]; other site 1305598002833 catalytic residue [active] 1305598002834 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1305598002835 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1305598002836 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1305598002837 MarR family; Region: MarR; pfam01047 1305598002838 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1305598002839 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1305598002840 amidase catalytic site [active] 1305598002841 Zn binding residues [ion binding]; other site 1305598002842 substrate binding site [chemical binding]; other site 1305598002843 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1305598002844 Lysozyme subfamily 2; Region: LYZ2; smart00047 1305598002845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598002846 Coenzyme A binding pocket [chemical binding]; other site 1305598002847 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1305598002848 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1305598002849 Beta-lactamase; Region: Beta-lactamase; pfam00144 1305598002850 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1305598002851 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1305598002852 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1305598002853 Subunit I/III interface [polypeptide binding]; other site 1305598002854 Subunit III/IV interface [polypeptide binding]; other site 1305598002855 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1305598002856 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1305598002857 D-pathway; other site 1305598002858 Putative ubiquinol binding site [chemical binding]; other site 1305598002859 Low-spin heme (heme b) binding site [chemical binding]; other site 1305598002860 Putative water exit pathway; other site 1305598002861 Binuclear center (heme o3/CuB) [ion binding]; other site 1305598002862 K-pathway; other site 1305598002863 Putative proton exit pathway; other site 1305598002864 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1305598002865 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1305598002866 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1305598002867 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1305598002868 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1305598002869 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1305598002870 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1305598002871 homodimer interface [polypeptide binding]; other site 1305598002872 NADP binding site [chemical binding]; other site 1305598002873 substrate binding site [chemical binding]; other site 1305598002874 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1305598002875 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1305598002876 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1305598002877 NAD binding site [chemical binding]; other site 1305598002878 ATP-grasp domain; Region: ATP-grasp; pfam02222 1305598002879 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1305598002880 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1305598002881 ATP binding site [chemical binding]; other site 1305598002882 active site 1305598002883 substrate binding site [chemical binding]; other site 1305598002884 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1305598002885 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1305598002886 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1305598002887 putative active site [active] 1305598002888 catalytic triad [active] 1305598002889 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1305598002890 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1305598002891 dimerization interface [polypeptide binding]; other site 1305598002892 ATP binding site [chemical binding]; other site 1305598002893 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1305598002894 dimerization interface [polypeptide binding]; other site 1305598002895 ATP binding site [chemical binding]; other site 1305598002896 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1305598002897 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1305598002898 active site 1305598002899 tetramer interface [polypeptide binding]; other site 1305598002900 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1305598002901 active site 1305598002902 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1305598002903 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1305598002904 dimerization interface [polypeptide binding]; other site 1305598002905 putative ATP binding site [chemical binding]; other site 1305598002906 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1305598002907 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1305598002908 active site 1305598002909 substrate binding site [chemical binding]; other site 1305598002910 cosubstrate binding site; other site 1305598002911 catalytic site [active] 1305598002912 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1305598002913 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1305598002914 purine monophosphate binding site [chemical binding]; other site 1305598002915 dimer interface [polypeptide binding]; other site 1305598002916 putative catalytic residues [active] 1305598002917 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1305598002918 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1305598002919 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1305598002920 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1305598002921 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1305598002922 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1305598002923 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1305598002924 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1305598002925 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1305598002926 Walker A/P-loop; other site 1305598002927 ATP binding site [chemical binding]; other site 1305598002928 Q-loop/lid; other site 1305598002929 ABC transporter signature motif; other site 1305598002930 Walker B; other site 1305598002931 D-loop; other site 1305598002932 H-loop/switch region; other site 1305598002933 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1305598002934 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1305598002935 Walker A/P-loop; other site 1305598002936 ATP binding site [chemical binding]; other site 1305598002937 Q-loop/lid; other site 1305598002938 ABC transporter signature motif; other site 1305598002939 Walker B; other site 1305598002940 D-loop; other site 1305598002941 H-loop/switch region; other site 1305598002942 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1305598002943 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1305598002944 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1305598002945 putative RNA binding site [nucleotide binding]; other site 1305598002946 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1305598002947 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1305598002948 dimerization domain swap beta strand [polypeptide binding]; other site 1305598002949 regulatory protein interface [polypeptide binding]; other site 1305598002950 active site 1305598002951 regulatory phosphorylation site [posttranslational modification]; other site 1305598002952 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1305598002953 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1305598002954 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1305598002955 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1305598002956 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1305598002957 catalytic residues [active] 1305598002958 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1305598002959 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1305598002960 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1305598002961 TrkA-N domain; Region: TrkA_N; pfam02254 1305598002962 TrkA-C domain; Region: TrkA_C; pfam02080 1305598002963 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1305598002964 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1305598002965 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1305598002966 hypothetical protein; Provisional; Region: PRK13667 1305598002967 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1305598002968 active site 1305598002969 catalytic residues [active] 1305598002970 metal binding site [ion binding]; metal-binding site 1305598002971 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1305598002972 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1305598002973 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1305598002974 TPP-binding site [chemical binding]; other site 1305598002975 tetramer interface [polypeptide binding]; other site 1305598002976 heterodimer interface [polypeptide binding]; other site 1305598002977 phosphorylation loop region [posttranslational modification] 1305598002978 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1305598002979 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1305598002980 alpha subunit interface [polypeptide binding]; other site 1305598002981 TPP binding site [chemical binding]; other site 1305598002982 heterodimer interface [polypeptide binding]; other site 1305598002983 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1305598002984 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1305598002985 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1305598002986 E3 interaction surface; other site 1305598002987 lipoyl attachment site [posttranslational modification]; other site 1305598002988 e3 binding domain; Region: E3_binding; pfam02817 1305598002989 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1305598002990 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1305598002991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1305598002992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598002993 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1305598002994 hypothetical protein; Provisional; Region: PRK04387 1305598002995 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1305598002996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1305598002997 non-specific DNA binding site [nucleotide binding]; other site 1305598002998 salt bridge; other site 1305598002999 sequence-specific DNA binding site [nucleotide binding]; other site 1305598003000 Cupin domain; Region: Cupin_2; pfam07883 1305598003001 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1305598003002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598003003 Walker A/P-loop; other site 1305598003004 ATP binding site [chemical binding]; other site 1305598003005 Q-loop/lid; other site 1305598003006 ABC transporter signature motif; other site 1305598003007 Walker B; other site 1305598003008 D-loop; other site 1305598003009 H-loop/switch region; other site 1305598003010 TOBE domain; Region: TOBE_2; pfam08402 1305598003011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598003012 putative PBP binding loops; other site 1305598003013 dimer interface [polypeptide binding]; other site 1305598003014 ABC-ATPase subunit interface; other site 1305598003015 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1305598003016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598003017 dimer interface [polypeptide binding]; other site 1305598003018 conserved gate region; other site 1305598003019 putative PBP binding loops; other site 1305598003020 ABC-ATPase subunit interface; other site 1305598003021 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1305598003022 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 1305598003023 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1305598003024 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1305598003025 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1305598003026 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1305598003027 manganese transport protein MntH; Reviewed; Region: PRK00701 1305598003028 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1305598003029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1305598003030 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1305598003031 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1305598003032 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1305598003033 active site 1305598003034 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1305598003035 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1305598003036 G1 box; other site 1305598003037 putative GEF interaction site [polypeptide binding]; other site 1305598003038 GTP/Mg2+ binding site [chemical binding]; other site 1305598003039 Switch I region; other site 1305598003040 G2 box; other site 1305598003041 G3 box; other site 1305598003042 Switch II region; other site 1305598003043 G4 box; other site 1305598003044 G5 box; other site 1305598003045 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1305598003046 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1305598003047 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1305598003048 hypothetical protein; Provisional; Region: PRK13666 1305598003049 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1305598003050 pyruvate carboxylase; Reviewed; Region: PRK12999 1305598003051 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1305598003052 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1305598003053 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1305598003054 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1305598003055 active site 1305598003056 catalytic residues [active] 1305598003057 metal binding site [ion binding]; metal-binding site 1305598003058 homodimer binding site [polypeptide binding]; other site 1305598003059 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1305598003060 carboxyltransferase (CT) interaction site; other site 1305598003061 biotinylation site [posttranslational modification]; other site 1305598003062 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1305598003063 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1305598003064 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1305598003065 UbiA prenyltransferase family; Region: UbiA; pfam01040 1305598003066 Predicted membrane protein [Function unknown]; Region: COG2322 1305598003067 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1305598003068 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1305598003069 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1305598003070 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1305598003071 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1305598003072 putative active site [active] 1305598003073 catalytic site [active] 1305598003074 putative metal binding site [ion binding]; other site 1305598003075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 1305598003076 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1305598003077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598003078 S-adenosylmethionine binding site [chemical binding]; other site 1305598003079 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1305598003080 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1305598003081 active site 1305598003082 (T/H)XGH motif; other site 1305598003083 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1305598003084 hypothetical protein; Provisional; Region: PRK13670 1305598003085 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1305598003086 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1305598003087 heme uptake protein IsdB; Region: IsdB; TIGR03657 1305598003088 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598003089 NEAr Transporter domain; Region: NEAT; smart00725 1305598003090 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1305598003091 heme-binding site [chemical binding]; other site 1305598003092 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1305598003093 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1305598003094 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1305598003095 heme-binding site [chemical binding]; other site 1305598003096 heme uptake protein IsdC; Region: IsdC; TIGR03656 1305598003097 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1305598003098 heme-binding site [chemical binding]; other site 1305598003099 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 1305598003100 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1305598003101 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1305598003102 intersubunit interface [polypeptide binding]; other site 1305598003103 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1305598003104 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598003105 ABC-ATPase subunit interface; other site 1305598003106 dimer interface [polypeptide binding]; other site 1305598003107 putative PBP binding regions; other site 1305598003108 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1305598003109 active site 1305598003110 catalytic site [active] 1305598003111 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 1305598003112 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1305598003113 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1305598003114 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1305598003115 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1305598003116 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1305598003117 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1305598003118 dimer interface [polypeptide binding]; other site 1305598003119 motif 1; other site 1305598003120 active site 1305598003121 motif 2; other site 1305598003122 motif 3; other site 1305598003123 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1305598003124 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1305598003125 putative tRNA-binding site [nucleotide binding]; other site 1305598003126 B3/4 domain; Region: B3_4; pfam03483 1305598003127 tRNA synthetase B5 domain; Region: B5; smart00874 1305598003128 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1305598003129 dimer interface [polypeptide binding]; other site 1305598003130 motif 1; other site 1305598003131 motif 3; other site 1305598003132 motif 2; other site 1305598003133 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1305598003134 ribonuclease HIII; Provisional; Region: PRK00996 1305598003135 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1305598003136 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1305598003137 RNA/DNA hybrid binding site [nucleotide binding]; other site 1305598003138 active site 1305598003139 Cell division protein ZapA; Region: ZapA; cl01146 1305598003140 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1305598003141 Colicin V production protein; Region: Colicin_V; pfam02674 1305598003142 hypothetical protein; Provisional; Region: PRK08609 1305598003143 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1305598003144 active site 1305598003145 primer binding site [nucleotide binding]; other site 1305598003146 NTP binding site [chemical binding]; other site 1305598003147 metal binding triad [ion binding]; metal-binding site 1305598003148 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1305598003149 active site 1305598003150 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1305598003151 MutS domain III; Region: MutS_III; pfam05192 1305598003152 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1305598003153 Walker A/P-loop; other site 1305598003154 ATP binding site [chemical binding]; other site 1305598003155 Q-loop/lid; other site 1305598003156 ABC transporter signature motif; other site 1305598003157 Walker B; other site 1305598003158 D-loop; other site 1305598003159 H-loop/switch region; other site 1305598003160 Smr domain; Region: Smr; pfam01713 1305598003161 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1305598003162 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1305598003163 catalytic residues [active] 1305598003164 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1305598003165 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1305598003166 GIY-YIG motif/motif A; other site 1305598003167 active site 1305598003168 catalytic site [active] 1305598003169 putative DNA binding site [nucleotide binding]; other site 1305598003170 metal binding site [ion binding]; metal-binding site 1305598003171 UvrB/uvrC motif; Region: UVR; pfam02151 1305598003172 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1305598003173 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1305598003174 putative Iron-sulfur protein interface [polypeptide binding]; other site 1305598003175 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1305598003176 proximal heme binding site [chemical binding]; other site 1305598003177 distal heme binding site [chemical binding]; other site 1305598003178 putative dimer interface [polypeptide binding]; other site 1305598003179 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1305598003180 L-aspartate oxidase; Provisional; Region: PRK06175 1305598003181 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1305598003182 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1305598003183 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1305598003184 glutamate racemase; Provisional; Region: PRK00865 1305598003185 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1305598003186 active site 1305598003187 dimerization interface [polypeptide binding]; other site 1305598003188 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1305598003189 active site 1305598003190 metal binding site [ion binding]; metal-binding site 1305598003191 homotetramer interface [polypeptide binding]; other site 1305598003192 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1305598003193 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 1305598003194 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1305598003195 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1305598003196 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1305598003197 superantigen-like protein; Reviewed; Region: PRK13350 1305598003198 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598003199 superantigen-like protein; Reviewed; Region: PRK13349 1305598003200 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598003201 superantigen-like protein; Reviewed; Region: PRK13043 1305598003202 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598003203 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1305598003204 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1305598003205 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1305598003206 carbamate kinase; Reviewed; Region: PRK12686 1305598003207 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1305598003208 putative substrate binding site [chemical binding]; other site 1305598003209 nucleotide binding site [chemical binding]; other site 1305598003210 nucleotide binding site [chemical binding]; other site 1305598003211 homodimer interface [polypeptide binding]; other site 1305598003212 Predicted membrane protein [Function unknown]; Region: COG1288 1305598003213 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1305598003214 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1305598003215 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1305598003216 gating phenylalanine in ion channel; other site 1305598003217 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1305598003218 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1305598003219 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1305598003220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598003221 motif II; other site 1305598003222 hypothetical protein; Provisional; Region: PRK13688 1305598003223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1305598003224 Coenzyme A binding pocket [chemical binding]; other site 1305598003225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1305598003226 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1305598003227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1305598003228 MraZ protein; Region: MraZ; pfam02381 1305598003229 MraZ protein; Region: MraZ; pfam02381 1305598003230 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1305598003231 MraW methylase family; Region: Methyltransf_5; pfam01795 1305598003232 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1305598003233 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1305598003234 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1305598003235 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1305598003236 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1305598003237 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1305598003238 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1305598003239 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1305598003240 Mg++ binding site [ion binding]; other site 1305598003241 putative catalytic motif [active] 1305598003242 putative substrate binding site [chemical binding]; other site 1305598003243 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1305598003244 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1305598003245 NAD binding site [chemical binding]; other site 1305598003246 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1305598003247 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1305598003248 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1305598003249 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1305598003250 Cell division protein FtsQ; Region: FtsQ; pfam03799 1305598003251 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1305598003252 Cell division protein FtsA; Region: FtsA; smart00842 1305598003253 Cell division protein FtsA; Region: FtsA; pfam14450 1305598003254 cell division protein FtsZ; Validated; Region: PRK09330 1305598003255 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1305598003256 nucleotide binding site [chemical binding]; other site 1305598003257 SulA interaction site; other site 1305598003258 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1305598003259 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1305598003260 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1305598003261 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1305598003262 catalytic residue [active] 1305598003263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1305598003264 YGGT family; Region: YGGT; pfam02325 1305598003265 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1305598003266 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1305598003267 RNA binding surface [nucleotide binding]; other site 1305598003268 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1305598003269 DivIVA domain; Region: DivI1A_domain; TIGR03544 1305598003270 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1305598003271 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1305598003272 HIGH motif; other site 1305598003273 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1305598003274 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1305598003275 active site 1305598003276 KMSKS motif; other site 1305598003277 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1305598003278 tRNA binding surface [nucleotide binding]; other site 1305598003279 anticodon binding site; other site 1305598003280 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1305598003281 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1305598003282 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1305598003283 active site 1305598003284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598003285 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1305598003286 lipoprotein signal peptidase; Provisional; Region: PRK14787 1305598003287 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1305598003288 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1305598003289 RNA binding surface [nucleotide binding]; other site 1305598003290 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1305598003291 active site 1305598003292 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1305598003293 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1305598003294 uracil transporter; Provisional; Region: PRK10720 1305598003295 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1305598003296 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1305598003297 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1305598003298 dihydroorotase; Validated; Region: pyrC; PRK09357 1305598003299 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1305598003300 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1305598003301 active site 1305598003302 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1305598003303 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1305598003304 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1305598003305 catalytic site [active] 1305598003306 subunit interface [polypeptide binding]; other site 1305598003307 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1305598003308 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1305598003309 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1305598003310 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1305598003311 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1305598003312 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1305598003313 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1305598003314 IMP binding site; other site 1305598003315 dimer interface [polypeptide binding]; other site 1305598003316 interdomain contacts; other site 1305598003317 partial ornithine binding site; other site 1305598003318 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1305598003319 active site 1305598003320 dimer interface [polypeptide binding]; other site 1305598003321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1305598003322 active site 1305598003323 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1305598003324 dimer interface [polypeptide binding]; other site 1305598003325 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1305598003326 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1305598003327 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1305598003328 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1305598003329 catalytic site [active] 1305598003330 G-X2-G-X-G-K; other site 1305598003331 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1305598003332 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1305598003333 Flavoprotein; Region: Flavoprotein; pfam02441 1305598003334 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1305598003335 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1305598003336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1305598003337 ATP binding site [chemical binding]; other site 1305598003338 putative Mg++ binding site [ion binding]; other site 1305598003339 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1305598003340 nucleotide binding region [chemical binding]; other site 1305598003341 ATP-binding site [chemical binding]; other site 1305598003342 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1305598003343 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1305598003344 active site 1305598003345 catalytic residues [active] 1305598003346 metal binding site [ion binding]; metal-binding site 1305598003347 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1305598003348 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1305598003349 putative active site [active] 1305598003350 substrate binding site [chemical binding]; other site 1305598003351 putative cosubstrate binding site; other site 1305598003352 catalytic site [active] 1305598003353 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1305598003354 substrate binding site [chemical binding]; other site 1305598003355 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1305598003356 NusB family; Region: NusB; pfam01029 1305598003357 putative RNA binding site [nucleotide binding]; other site 1305598003358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598003359 S-adenosylmethionine binding site [chemical binding]; other site 1305598003360 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1305598003361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1305598003362 FeS/SAM binding site; other site 1305598003363 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1305598003364 Protein phosphatase 2C; Region: PP2C; pfam00481 1305598003365 active site 1305598003366 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1305598003367 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1305598003368 active site 1305598003369 ATP binding site [chemical binding]; other site 1305598003370 substrate binding site [chemical binding]; other site 1305598003371 activation loop (A-loop); other site 1305598003372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1305598003373 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1305598003374 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1305598003375 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1305598003376 Predicted GTPases [General function prediction only]; Region: COG1162 1305598003377 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1305598003378 RNA binding site [nucleotide binding]; other site 1305598003379 homodimer interface [polypeptide binding]; other site 1305598003380 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1305598003381 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1305598003382 GTP/Mg2+ binding site [chemical binding]; other site 1305598003383 G4 box; other site 1305598003384 G5 box; other site 1305598003385 G1 box; other site 1305598003386 Switch I region; other site 1305598003387 G2 box; other site 1305598003388 G3 box; other site 1305598003389 Switch II region; other site 1305598003390 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1305598003391 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1305598003392 substrate binding site [chemical binding]; other site 1305598003393 hexamer interface [polypeptide binding]; other site 1305598003394 metal binding site [ion binding]; metal-binding site 1305598003395 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1305598003396 Thiamine pyrophosphokinase; Region: TPK; cd07995 1305598003397 active site 1305598003398 dimerization interface [polypeptide binding]; other site 1305598003399 thiamine binding site [chemical binding]; other site 1305598003400 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1305598003401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1305598003402 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1305598003403 DAK2 domain; Region: Dak2; pfam02734 1305598003404 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1305598003405 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1305598003406 generic binding surface II; other site 1305598003407 ssDNA binding site; other site 1305598003408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1305598003409 ATP binding site [chemical binding]; other site 1305598003410 putative Mg++ binding site [ion binding]; other site 1305598003411 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1305598003412 nucleotide binding region [chemical binding]; other site 1305598003413 ATP-binding site [chemical binding]; other site 1305598003414 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1305598003415 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1305598003416 active site 2 [active] 1305598003417 active site 1 [active] 1305598003418 putative phosphate acyltransferase; Provisional; Region: PRK05331 1305598003419 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1305598003420 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1305598003421 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1305598003422 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1305598003423 NAD(P) binding site [chemical binding]; other site 1305598003424 homotetramer interface [polypeptide binding]; other site 1305598003425 homodimer interface [polypeptide binding]; other site 1305598003426 active site 1305598003427 acyl carrier protein; Provisional; Region: acpP; PRK00982 1305598003428 ribonuclease III; Reviewed; Region: rnc; PRK00102 1305598003429 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1305598003430 dimerization interface [polypeptide binding]; other site 1305598003431 active site 1305598003432 metal binding site [ion binding]; metal-binding site 1305598003433 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1305598003434 dsRNA binding site [nucleotide binding]; other site 1305598003435 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1305598003436 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1305598003437 Walker A/P-loop; other site 1305598003438 ATP binding site [chemical binding]; other site 1305598003439 Q-loop/lid; other site 1305598003440 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1305598003441 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1305598003442 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1305598003443 ABC transporter signature motif; other site 1305598003444 Walker B; other site 1305598003445 D-loop; other site 1305598003446 H-loop/switch region; other site 1305598003447 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1305598003448 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1305598003449 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1305598003450 P loop; other site 1305598003451 GTP binding site [chemical binding]; other site 1305598003452 putative DNA-binding protein; Validated; Region: PRK00118 1305598003453 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1305598003454 signal recognition particle protein; Provisional; Region: PRK10867 1305598003455 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1305598003456 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1305598003457 P loop; other site 1305598003458 GTP binding site [chemical binding]; other site 1305598003459 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1305598003460 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1305598003461 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1305598003462 RimM N-terminal domain; Region: RimM; pfam01782 1305598003463 PRC-barrel domain; Region: PRC; pfam05239 1305598003464 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1305598003465 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1305598003466 Predicted membrane protein [Function unknown]; Region: COG4485 1305598003467 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1305598003468 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1305598003469 GTP/Mg2+ binding site [chemical binding]; other site 1305598003470 G4 box; other site 1305598003471 G5 box; other site 1305598003472 G1 box; other site 1305598003473 Switch I region; other site 1305598003474 G2 box; other site 1305598003475 G3 box; other site 1305598003476 Switch II region; other site 1305598003477 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1305598003478 RNA/DNA hybrid binding site [nucleotide binding]; other site 1305598003479 active site 1305598003480 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1305598003481 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1305598003482 CoA-ligase; Region: Ligase_CoA; pfam00549 1305598003483 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1305598003484 CoA binding domain; Region: CoA_binding; pfam02629 1305598003485 CoA-ligase; Region: Ligase_CoA; pfam00549 1305598003486 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1305598003487 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1305598003488 CHAP domain; Region: CHAP; pfam05257 1305598003489 FemAB family; Region: FemAB; pfam02388 1305598003490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1305598003491 DNA protecting protein DprA; Region: dprA; TIGR00732 1305598003492 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1305598003493 DNA topoisomerase I; Validated; Region: PRK05582 1305598003494 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1305598003495 active site 1305598003496 interdomain interaction site; other site 1305598003497 putative metal-binding site [ion binding]; other site 1305598003498 nucleotide binding site [chemical binding]; other site 1305598003499 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1305598003500 domain I; other site 1305598003501 DNA binding groove [nucleotide binding] 1305598003502 phosphate binding site [ion binding]; other site 1305598003503 domain II; other site 1305598003504 domain III; other site 1305598003505 nucleotide binding site [chemical binding]; other site 1305598003506 catalytic site [active] 1305598003507 domain IV; other site 1305598003508 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1305598003509 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1305598003510 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1305598003511 Glucose inhibited division protein A; Region: GIDA; pfam01134 1305598003512 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1305598003513 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1305598003514 active site 1305598003515 DNA binding site [nucleotide binding] 1305598003516 Int/Topo IB signature motif; other site 1305598003517 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1305598003518 active site 1305598003519 HslU subunit interaction site [polypeptide binding]; other site 1305598003520 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1305598003521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598003522 Walker A motif; other site 1305598003523 ATP binding site [chemical binding]; other site 1305598003524 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1305598003525 Walker B motif; other site 1305598003526 arginine finger; other site 1305598003527 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1305598003528 transcriptional repressor CodY; Validated; Region: PRK04158 1305598003529 CodY GAF-like domain; Region: CodY; pfam06018 1305598003530 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1305598003531 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1305598003532 rRNA interaction site [nucleotide binding]; other site 1305598003533 S8 interaction site; other site 1305598003534 putative laminin-1 binding site; other site 1305598003535 elongation factor Ts; Provisional; Region: tsf; PRK09377 1305598003536 UBA/TS-N domain; Region: UBA; pfam00627 1305598003537 Elongation factor TS; Region: EF_TS; pfam00889 1305598003538 Elongation factor TS; Region: EF_TS; pfam00889 1305598003539 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1305598003540 putative nucleotide binding site [chemical binding]; other site 1305598003541 uridine monophosphate binding site [chemical binding]; other site 1305598003542 homohexameric interface [polypeptide binding]; other site 1305598003543 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1305598003544 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1305598003545 hinge region; other site 1305598003546 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1305598003547 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1305598003548 catalytic residue [active] 1305598003549 putative FPP diphosphate binding site; other site 1305598003550 putative FPP binding hydrophobic cleft; other site 1305598003551 dimer interface [polypeptide binding]; other site 1305598003552 putative IPP diphosphate binding site; other site 1305598003553 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1305598003554 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1305598003555 RIP metalloprotease RseP; Region: TIGR00054 1305598003556 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1305598003557 active site 1305598003558 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1305598003559 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1305598003560 protein binding site [polypeptide binding]; other site 1305598003561 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1305598003562 putative substrate binding region [chemical binding]; other site 1305598003563 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1305598003564 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1305598003565 dimer interface [polypeptide binding]; other site 1305598003566 motif 1; other site 1305598003567 active site 1305598003568 motif 2; other site 1305598003569 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1305598003570 putative deacylase active site [active] 1305598003571 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1305598003572 active site 1305598003573 motif 3; other site 1305598003574 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1305598003575 anticodon binding site; other site 1305598003576 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1305598003577 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1305598003578 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1305598003579 generic binding surface II; other site 1305598003580 generic binding surface I; other site 1305598003581 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1305598003582 active site 1305598003583 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1305598003584 active site 1305598003585 catalytic site [active] 1305598003586 substrate binding site [chemical binding]; other site 1305598003587 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1305598003588 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1305598003589 Sm and related proteins; Region: Sm_like; cl00259 1305598003590 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1305598003591 putative oligomer interface [polypeptide binding]; other site 1305598003592 putative RNA binding site [nucleotide binding]; other site 1305598003593 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1305598003594 NusA N-terminal domain; Region: NusA_N; pfam08529 1305598003595 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1305598003596 RNA binding site [nucleotide binding]; other site 1305598003597 homodimer interface [polypeptide binding]; other site 1305598003598 NusA-like KH domain; Region: KH_5; pfam13184 1305598003599 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1305598003600 G-X-X-G motif; other site 1305598003601 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1305598003602 putative RNA binding cleft [nucleotide binding]; other site 1305598003603 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1305598003604 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1305598003605 translation initiation factor IF-2; Region: IF-2; TIGR00487 1305598003606 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1305598003607 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1305598003608 G1 box; other site 1305598003609 putative GEF interaction site [polypeptide binding]; other site 1305598003610 GTP/Mg2+ binding site [chemical binding]; other site 1305598003611 Switch I region; other site 1305598003612 G2 box; other site 1305598003613 G3 box; other site 1305598003614 Switch II region; other site 1305598003615 G4 box; other site 1305598003616 G5 box; other site 1305598003617 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1305598003618 Translation-initiation factor 2; Region: IF-2; pfam11987 1305598003619 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1305598003620 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1305598003621 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1305598003622 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1305598003623 RNA binding site [nucleotide binding]; other site 1305598003624 active site 1305598003625 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1305598003626 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1305598003627 active site 1305598003628 Riboflavin kinase; Region: Flavokinase; smart00904 1305598003629 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1305598003630 16S/18S rRNA binding site [nucleotide binding]; other site 1305598003631 S13e-L30e interaction site [polypeptide binding]; other site 1305598003632 25S rRNA binding site [nucleotide binding]; other site 1305598003633 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1305598003634 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1305598003635 RNase E interface [polypeptide binding]; other site 1305598003636 trimer interface [polypeptide binding]; other site 1305598003637 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1305598003638 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1305598003639 RNase E interface [polypeptide binding]; other site 1305598003640 trimer interface [polypeptide binding]; other site 1305598003641 active site 1305598003642 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1305598003643 putative nucleic acid binding region [nucleotide binding]; other site 1305598003644 G-X-X-G motif; other site 1305598003645 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1305598003646 RNA binding site [nucleotide binding]; other site 1305598003647 domain interface; other site 1305598003648 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1305598003649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1305598003650 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1305598003651 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1305598003652 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1305598003653 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1305598003654 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1305598003655 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1305598003656 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1305598003657 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1305598003658 DNA-binding site [nucleotide binding]; DNA binding site 1305598003659 UTRA domain; Region: UTRA; pfam07702 1305598003660 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1305598003661 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1305598003662 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1305598003663 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1305598003664 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1305598003665 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1305598003666 classical (c) SDRs; Region: SDR_c; cd05233 1305598003667 NAD(P) binding site [chemical binding]; other site 1305598003668 active site 1305598003669 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1305598003670 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1305598003671 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1305598003672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1305598003673 non-specific DNA binding site [nucleotide binding]; other site 1305598003674 salt bridge; other site 1305598003675 sequence-specific DNA binding site [nucleotide binding]; other site 1305598003676 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1305598003677 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1305598003678 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1305598003679 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1305598003680 putative MPT binding site; other site 1305598003681 recombinase A; Provisional; Region: recA; PRK09354 1305598003682 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1305598003683 hexamer interface [polypeptide binding]; other site 1305598003684 Walker A motif; other site 1305598003685 ATP binding site [chemical binding]; other site 1305598003686 Walker B motif; other site 1305598003687 phosphodiesterase; Provisional; Region: PRK12704 1305598003688 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1305598003689 Zn2+ binding site [ion binding]; other site 1305598003690 Mg2+ binding site [ion binding]; other site 1305598003691 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1305598003692 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1305598003693 putative active site [active] 1305598003694 metal binding site [ion binding]; metal-binding site 1305598003695 homodimer binding site [polypeptide binding]; other site 1305598003696 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1305598003697 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1305598003698 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1305598003699 dimer interface [polypeptide binding]; other site 1305598003700 PYR/PP interface [polypeptide binding]; other site 1305598003701 TPP binding site [chemical binding]; other site 1305598003702 substrate binding site [chemical binding]; other site 1305598003703 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1305598003704 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1305598003705 TPP-binding site [chemical binding]; other site 1305598003706 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1305598003707 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1305598003708 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1305598003709 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1305598003710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1305598003711 FeS/SAM binding site; other site 1305598003712 TRAM domain; Region: TRAM; pfam01938 1305598003713 Predicted membrane protein [Function unknown]; Region: COG4550 1305598003714 Predicted membrane protein [Function unknown]; Region: COG4732 1305598003715 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1305598003716 MutS domain I; Region: MutS_I; pfam01624 1305598003717 MutS domain II; Region: MutS_II; pfam05188 1305598003718 MutS domain III; Region: MutS_III; pfam05192 1305598003719 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1305598003720 Walker A/P-loop; other site 1305598003721 ATP binding site [chemical binding]; other site 1305598003722 Q-loop/lid; other site 1305598003723 ABC transporter signature motif; other site 1305598003724 Walker B; other site 1305598003725 D-loop; other site 1305598003726 H-loop/switch region; other site 1305598003727 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1305598003728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598003729 ATP binding site [chemical binding]; other site 1305598003730 Mg2+ binding site [ion binding]; other site 1305598003731 G-X-G motif; other site 1305598003732 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1305598003733 ATP binding site [chemical binding]; other site 1305598003734 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1305598003735 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 1305598003736 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1305598003737 amphipathic channel; other site 1305598003738 Asn-Pro-Ala signature motifs; other site 1305598003739 glycerol kinase; Provisional; Region: glpK; PRK00047 1305598003740 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1305598003741 N- and C-terminal domain interface [polypeptide binding]; other site 1305598003742 active site 1305598003743 MgATP binding site [chemical binding]; other site 1305598003744 catalytic site [active] 1305598003745 metal binding site [ion binding]; metal-binding site 1305598003746 glycerol binding site [chemical binding]; other site 1305598003747 homotetramer interface [polypeptide binding]; other site 1305598003748 homodimer interface [polypeptide binding]; other site 1305598003749 FBP binding site [chemical binding]; other site 1305598003750 protein IIAGlc interface [polypeptide binding]; other site 1305598003751 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1305598003752 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1305598003753 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1305598003754 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 1305598003755 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1305598003756 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1305598003757 bacterial Hfq-like; Region: Hfq; cd01716 1305598003758 hexamer interface [polypeptide binding]; other site 1305598003759 Sm1 motif; other site 1305598003760 RNA binding site [nucleotide binding]; other site 1305598003761 Sm2 motif; other site 1305598003762 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1305598003763 catalytic residues [active] 1305598003764 dimer interface [polypeptide binding]; other site 1305598003765 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1305598003766 HflX GTPase family; Region: HflX; cd01878 1305598003767 G1 box; other site 1305598003768 GTP/Mg2+ binding site [chemical binding]; other site 1305598003769 Switch I region; other site 1305598003770 G2 box; other site 1305598003771 G3 box; other site 1305598003772 Switch II region; other site 1305598003773 G4 box; other site 1305598003774 G5 box; other site 1305598003775 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1305598003776 Aluminium resistance protein; Region: Alum_res; pfam06838 1305598003777 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1305598003778 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1305598003779 DNA binding residues [nucleotide binding] 1305598003780 putative dimer interface [polypeptide binding]; other site 1305598003781 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1305598003782 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1305598003783 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1305598003784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1305598003785 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1305598003786 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1305598003787 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1305598003788 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1305598003789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1305598003790 catalytic residue [active] 1305598003791 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1305598003792 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1305598003793 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1305598003794 putative active site [active] 1305598003795 catalytic site [active] 1305598003796 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1305598003797 putative active site [active] 1305598003798 catalytic site [active] 1305598003799 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1305598003800 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1305598003801 Walker A/P-loop; other site 1305598003802 ATP binding site [chemical binding]; other site 1305598003803 Q-loop/lid; other site 1305598003804 ABC transporter signature motif; other site 1305598003805 Walker B; other site 1305598003806 D-loop; other site 1305598003807 H-loop/switch region; other site 1305598003808 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1305598003809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1305598003810 Histidine kinase; Region: HisKA_3; pfam07730 1305598003811 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1305598003812 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1305598003813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598003814 active site 1305598003815 phosphorylation site [posttranslational modification] 1305598003816 intermolecular recognition site; other site 1305598003817 dimerization interface [polypeptide binding]; other site 1305598003818 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1305598003819 DNA binding residues [nucleotide binding] 1305598003820 dimerization interface [polypeptide binding]; other site 1305598003821 Staphylococcal nuclease homologues; Region: SNc; smart00318 1305598003822 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1305598003823 Catalytic site; other site 1305598003824 AAA domain; Region: AAA_11; pfam13086 1305598003825 aspartate kinase; Reviewed; Region: PRK09034 1305598003826 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1305598003827 putative catalytic residues [active] 1305598003828 putative nucleotide binding site [chemical binding]; other site 1305598003829 putative aspartate binding site [chemical binding]; other site 1305598003830 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1305598003831 allosteric regulatory residue; other site 1305598003832 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1305598003833 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1305598003834 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1305598003835 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1305598003836 threonine synthase; Reviewed; Region: PRK06721 1305598003837 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1305598003838 homodimer interface [polypeptide binding]; other site 1305598003839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598003840 catalytic residue [active] 1305598003841 homoserine kinase; Provisional; Region: PRK01212 1305598003842 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1305598003843 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1305598003844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598003845 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1305598003846 active site 1305598003847 motif I; other site 1305598003848 motif II; other site 1305598003849 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1305598003850 lysine transporter; Provisional; Region: PRK10836 1305598003851 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1305598003852 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1305598003853 tetramer interface [polypeptide binding]; other site 1305598003854 heme binding pocket [chemical binding]; other site 1305598003855 NADPH binding site [chemical binding]; other site 1305598003856 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1305598003857 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1305598003858 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1305598003859 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1305598003860 active site 1305598003861 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1305598003862 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1305598003863 LexA repressor; Validated; Region: PRK00215 1305598003864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1305598003865 putative DNA binding site [nucleotide binding]; other site 1305598003866 putative Zn2+ binding site [ion binding]; other site 1305598003867 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1305598003868 Catalytic site [active] 1305598003869 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1305598003870 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1305598003871 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1305598003872 TPP-binding site [chemical binding]; other site 1305598003873 dimer interface [polypeptide binding]; other site 1305598003874 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1305598003875 PYR/PP interface [polypeptide binding]; other site 1305598003876 dimer interface [polypeptide binding]; other site 1305598003877 TPP binding site [chemical binding]; other site 1305598003878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1305598003879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1305598003880 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1305598003881 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1305598003882 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1305598003883 active site 1305598003884 metal binding site [ion binding]; metal-binding site 1305598003885 DNA binding site [nucleotide binding] 1305598003886 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1305598003887 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1305598003888 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1305598003889 Walker A/P-loop; other site 1305598003890 ATP binding site [chemical binding]; other site 1305598003891 Q-loop/lid; other site 1305598003892 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1305598003893 ABC transporter signature motif; other site 1305598003894 Walker B; other site 1305598003895 D-loop; other site 1305598003896 H-loop/switch region; other site 1305598003897 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1305598003898 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1305598003899 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1305598003900 aconitate hydratase; Validated; Region: PRK09277 1305598003901 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1305598003902 substrate binding site [chemical binding]; other site 1305598003903 ligand binding site [chemical binding]; other site 1305598003904 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1305598003905 substrate binding site [chemical binding]; other site 1305598003906 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1305598003907 active site 1305598003908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1305598003909 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1305598003910 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1305598003911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598003912 ATP binding site [chemical binding]; other site 1305598003913 Mg2+ binding site [ion binding]; other site 1305598003914 G-X-G motif; other site 1305598003915 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1305598003916 anchoring element; other site 1305598003917 dimer interface [polypeptide binding]; other site 1305598003918 ATP binding site [chemical binding]; other site 1305598003919 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1305598003920 active site 1305598003921 putative metal-binding site [ion binding]; other site 1305598003922 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1305598003923 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1305598003924 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1305598003925 CAP-like domain; other site 1305598003926 active site 1305598003927 primary dimer interface [polypeptide binding]; other site 1305598003928 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1305598003929 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1305598003930 amino acid carrier protein; Region: agcS; TIGR00835 1305598003931 CAT RNA binding domain; Region: CAT_RBD; smart01061 1305598003932 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1305598003933 PRD domain; Region: PRD; pfam00874 1305598003934 PRD domain; Region: PRD; pfam00874 1305598003935 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1305598003936 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1305598003937 Predicted integral membrane protein [Function unknown]; Region: COG0392 1305598003938 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1305598003939 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1305598003940 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1305598003941 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1305598003942 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1305598003943 active site 1 [active] 1305598003944 dimer interface [polypeptide binding]; other site 1305598003945 hexamer interface [polypeptide binding]; other site 1305598003946 active site 2 [active] 1305598003947 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1305598003948 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1305598003949 active site 1305598003950 DNA binding site [nucleotide binding] 1305598003951 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1305598003952 prephenate dehydrogenase; Validated; Region: PRK06545 1305598003953 prephenate dehydrogenase; Validated; Region: PRK08507 1305598003954 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1305598003955 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1305598003956 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1305598003957 putative oligomer interface [polypeptide binding]; other site 1305598003958 putative active site [active] 1305598003959 metal binding site [ion binding]; metal-binding site 1305598003960 anthranilate synthase component I; Provisional; Region: PRK13567 1305598003961 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1305598003962 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1305598003963 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1305598003964 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1305598003965 glutamine binding [chemical binding]; other site 1305598003966 catalytic triad [active] 1305598003967 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1305598003968 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1305598003969 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1305598003970 active site 1305598003971 ribulose/triose binding site [chemical binding]; other site 1305598003972 phosphate binding site [ion binding]; other site 1305598003973 substrate (anthranilate) binding pocket [chemical binding]; other site 1305598003974 product (indole) binding pocket [chemical binding]; other site 1305598003975 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1305598003976 active site 1305598003977 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1305598003978 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1305598003979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598003980 catalytic residue [active] 1305598003981 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1305598003982 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1305598003983 substrate binding site [chemical binding]; other site 1305598003984 active site 1305598003985 catalytic residues [active] 1305598003986 heterodimer interface [polypeptide binding]; other site 1305598003987 FemAB family; Region: FemAB; pfam02388 1305598003988 FlxA-like protein; Region: FlxA; pfam14282 1305598003989 FemAB family; Region: FemAB; pfam02388 1305598003990 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1305598003991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598003992 active site 1305598003993 motif I; other site 1305598003994 motif II; other site 1305598003995 SWIM zinc finger; Region: SWIM; pfam04434 1305598003996 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1305598003997 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1305598003998 Walker A/P-loop; other site 1305598003999 ATP binding site [chemical binding]; other site 1305598004000 Q-loop/lid; other site 1305598004001 ABC transporter signature motif; other site 1305598004002 Walker B; other site 1305598004003 D-loop; other site 1305598004004 H-loop/switch region; other site 1305598004005 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1305598004006 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1305598004007 Walker A/P-loop; other site 1305598004008 ATP binding site [chemical binding]; other site 1305598004009 Q-loop/lid; other site 1305598004010 ABC transporter signature motif; other site 1305598004011 Walker B; other site 1305598004012 D-loop; other site 1305598004013 H-loop/switch region; other site 1305598004014 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1305598004015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598004016 dimer interface [polypeptide binding]; other site 1305598004017 conserved gate region; other site 1305598004018 putative PBP binding loops; other site 1305598004019 ABC-ATPase subunit interface; other site 1305598004020 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1305598004021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598004022 dimer interface [polypeptide binding]; other site 1305598004023 conserved gate region; other site 1305598004024 putative PBP binding loops; other site 1305598004025 ABC-ATPase subunit interface; other site 1305598004026 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1305598004027 oligoendopeptidase F; Region: pepF; TIGR00181 1305598004028 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1305598004029 active site 1305598004030 Zn binding site [ion binding]; other site 1305598004031 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1305598004032 PhoU domain; Region: PhoU; pfam01895 1305598004033 PhoU domain; Region: PhoU; pfam01895 1305598004034 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1305598004035 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1305598004036 Walker A/P-loop; other site 1305598004037 ATP binding site [chemical binding]; other site 1305598004038 Q-loop/lid; other site 1305598004039 ABC transporter signature motif; other site 1305598004040 Walker B; other site 1305598004041 D-loop; other site 1305598004042 H-loop/switch region; other site 1305598004043 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1305598004044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598004045 dimer interface [polypeptide binding]; other site 1305598004046 conserved gate region; other site 1305598004047 putative PBP binding loops; other site 1305598004048 ABC-ATPase subunit interface; other site 1305598004049 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1305598004050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598004051 dimer interface [polypeptide binding]; other site 1305598004052 conserved gate region; other site 1305598004053 ABC-ATPase subunit interface; other site 1305598004054 phosphate binding protein; Region: ptsS_2; TIGR02136 1305598004055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598004056 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1305598004057 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1305598004058 S1 domain; Region: S1_2; pfam13509 1305598004059 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1305598004060 ABC transporter; Region: ABC_tran_2; pfam12848 1305598004061 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1305598004062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1305598004063 aspartate kinase; Reviewed; Region: PRK06635 1305598004064 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1305598004065 putative nucleotide binding site [chemical binding]; other site 1305598004066 putative catalytic residues [active] 1305598004067 putative Mg ion binding site [ion binding]; other site 1305598004068 putative aspartate binding site [chemical binding]; other site 1305598004069 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1305598004070 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1305598004071 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1305598004072 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1305598004073 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1305598004074 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1305598004075 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1305598004076 dimer interface [polypeptide binding]; other site 1305598004077 active site 1305598004078 catalytic residue [active] 1305598004079 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1305598004080 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1305598004081 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1305598004082 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1305598004083 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1305598004084 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1305598004085 active site 1305598004086 trimer interface [polypeptide binding]; other site 1305598004087 substrate binding site [chemical binding]; other site 1305598004088 CoA binding site [chemical binding]; other site 1305598004089 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1305598004090 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1305598004091 metal binding site [ion binding]; metal-binding site 1305598004092 dimer interface [polypeptide binding]; other site 1305598004093 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1305598004094 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1305598004095 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1305598004096 catalytic residue [active] 1305598004097 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1305598004098 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1305598004099 active site 1305598004100 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1305598004101 substrate binding site [chemical binding]; other site 1305598004102 catalytic residues [active] 1305598004103 dimer interface [polypeptide binding]; other site 1305598004104 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1305598004105 DNA-binding site [nucleotide binding]; DNA binding site 1305598004106 RNA-binding motif; other site 1305598004107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 1305598004108 acylphosphatase; Provisional; Region: PRK14431 1305598004109 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1305598004110 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1305598004111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598004112 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1305598004113 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1305598004114 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1305598004115 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1305598004116 metal ion-dependent adhesion site (MIDAS); other site 1305598004117 MoxR-like ATPases [General function prediction only]; Region: COG0714 1305598004118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598004119 Walker A motif; other site 1305598004120 ATP binding site [chemical binding]; other site 1305598004121 Walker B motif; other site 1305598004122 arginine finger; other site 1305598004123 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1305598004124 active site 1305598004125 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1305598004126 active site 1305598004127 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1305598004128 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1305598004129 E3 interaction surface; other site 1305598004130 lipoyl attachment site [posttranslational modification]; other site 1305598004131 e3 binding domain; Region: E3_binding; pfam02817 1305598004132 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1305598004133 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1305598004134 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1305598004135 TPP-binding site [chemical binding]; other site 1305598004136 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1305598004137 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1305598004138 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1305598004139 HAMP domain; Region: HAMP; pfam00672 1305598004140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1305598004141 dimer interface [polypeptide binding]; other site 1305598004142 phosphorylation site [posttranslational modification] 1305598004143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598004144 ATP binding site [chemical binding]; other site 1305598004145 Mg2+ binding site [ion binding]; other site 1305598004146 G-X-G motif; other site 1305598004147 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1305598004148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598004149 active site 1305598004150 phosphorylation site [posttranslational modification] 1305598004151 intermolecular recognition site; other site 1305598004152 dimerization interface [polypeptide binding]; other site 1305598004153 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1305598004154 DNA binding site [nucleotide binding] 1305598004155 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1305598004156 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1305598004157 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1305598004158 active site 1305598004159 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1305598004160 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1305598004161 active site 1305598004162 homodimer interface [polypeptide binding]; other site 1305598004163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598004164 Coenzyme A binding pocket [chemical binding]; other site 1305598004165 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1305598004166 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1305598004167 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1305598004168 protein binding site [polypeptide binding]; other site 1305598004169 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1305598004170 Catalytic dyad [active] 1305598004171 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1305598004172 hypothetical protein; Provisional; Region: PRK13672 1305598004173 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1305598004174 HPr interaction site; other site 1305598004175 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1305598004176 active site 1305598004177 phosphorylation site [posttranslational modification] 1305598004178 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1305598004179 SelR domain; Region: SelR; pfam01641 1305598004180 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1305598004181 EDD domain protein, DegV family; Region: DegV; TIGR00762 1305598004182 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1305598004183 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1305598004184 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1305598004185 folate binding site [chemical binding]; other site 1305598004186 NADP+ binding site [chemical binding]; other site 1305598004187 thymidylate synthase; Region: thym_sym; TIGR03284 1305598004188 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1305598004189 dimerization interface [polypeptide binding]; other site 1305598004190 active site 1305598004191 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1305598004192 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1305598004193 Virulence factor; Region: Virulence_fact; pfam13769 1305598004194 HEAT repeats; Region: HEAT_2; pfam13646 1305598004195 HEAT repeat; Region: HEAT; pfam02985 1305598004196 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1305598004197 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1305598004198 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1305598004199 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1305598004200 RNA/DNA hybrid binding site [nucleotide binding]; other site 1305598004201 active site 1305598004202 GA module; Region: GA; smart00844 1305598004203 GA module; Region: GA; smart00844 1305598004204 GA module; Region: GA; smart00844 1305598004205 GA module; Region: GA; smart00844 1305598004206 GA module; Region: GA; smart00844 1305598004207 GA module; Region: GA; smart00844 1305598004208 GA module; Region: GA; smart00844 1305598004209 GA module; Region: GA; smart00844 1305598004210 GA module; Region: GA; pfam01468 1305598004211 GA module; Region: GA; smart00844 1305598004212 GA module; Region: GA; smart00844 1305598004213 GA module; Region: GA; smart00844 1305598004214 GA module; Region: GA; smart00844 1305598004215 GA module; Region: GA; smart00844 1305598004216 GA module; Region: GA; smart00844 1305598004217 GA module; Region: GA; smart00844 1305598004218 GA module; Region: GA; smart00844 1305598004219 GA module; Region: GA; smart00844 1305598004220 GA module; Region: GA; smart00844 1305598004221 GA module; Region: GA; pfam01468 1305598004222 GA module; Region: GA; smart00844 1305598004223 GA module; Region: GA; smart00844 1305598004224 GA module; Region: GA; smart00844 1305598004225 GA module; Region: GA; smart00844 1305598004226 GA module; Region: GA; smart00844 1305598004227 GA module; Region: GA; smart00844 1305598004228 GA module; Region: GA; smart00844 1305598004229 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1305598004230 GA module; Region: GA; smart00844 1305598004231 GA module; Region: GA; smart00844 1305598004232 GA module; Region: GA; smart00844 1305598004233 GA module; Region: GA; smart00844 1305598004234 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598004235 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1305598004236 Integrase core domain; Region: rve; pfam00665 1305598004237 Homeodomain-like domain; Region: HTH_32; pfam13565 1305598004238 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1305598004239 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1305598004240 Surface antigen [General function prediction only]; Region: COG3942 1305598004241 CHAP domain; Region: CHAP; pfam05257 1305598004242 ribonuclease E; Reviewed; Region: rne; PRK10811 1305598004243 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1305598004244 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1305598004245 AAA-like domain; Region: AAA_10; pfam12846 1305598004246 TcpE family; Region: TcpE; pfam12648 1305598004247 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1305598004248 Replication initiation factor; Region: Rep_trans; pfam02486 1305598004249 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1305598004250 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598004251 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1305598004252 GA module; Region: GA; smart00844 1305598004253 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1305598004254 GA module; Region: GA; smart00844 1305598004255 GA module; Region: GA; smart00844 1305598004256 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1305598004257 GA module; Region: GA; smart00844 1305598004258 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1305598004259 GA module; Region: GA; smart00844 1305598004260 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1305598004261 GA module; Region: GA; smart00844 1305598004262 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1305598004263 GA module; Region: GA; smart00844 1305598004264 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1305598004265 GA module; Region: GA; smart00844 1305598004266 GA module; Region: GA; smart00844 1305598004267 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1305598004268 GA module; Region: GA; smart00844 1305598004269 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1305598004270 GA module; Region: GA; smart00844 1305598004271 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1305598004272 Amino acid permease; Region: AA_permease_2; pfam13520 1305598004273 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1305598004274 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1305598004275 tetramer interface [polypeptide binding]; other site 1305598004276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598004277 catalytic residue [active] 1305598004278 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1305598004279 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1305598004280 hexamer interface [polypeptide binding]; other site 1305598004281 ligand binding site [chemical binding]; other site 1305598004282 putative active site [active] 1305598004283 NAD(P) binding site [chemical binding]; other site 1305598004284 5'-3' exonuclease; Region: 53EXOc; smart00475 1305598004285 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1305598004286 active site 1305598004287 metal binding site 1 [ion binding]; metal-binding site 1305598004288 putative 5' ssDNA interaction site; other site 1305598004289 metal binding site 3; metal-binding site 1305598004290 metal binding site 2 [ion binding]; metal-binding site 1305598004291 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1305598004292 putative DNA binding site [nucleotide binding]; other site 1305598004293 putative metal binding site [ion binding]; other site 1305598004294 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1305598004295 Dynamin family; Region: Dynamin_N; pfam00350 1305598004296 G1 box; other site 1305598004297 GTP/Mg2+ binding site [chemical binding]; other site 1305598004298 G2 box; other site 1305598004299 Switch I region; other site 1305598004300 G3 box; other site 1305598004301 Switch II region; other site 1305598004302 G4 box; other site 1305598004303 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1305598004304 Dynamin family; Region: Dynamin_N; pfam00350 1305598004305 G1 box; other site 1305598004306 GTP/Mg2+ binding site [chemical binding]; other site 1305598004307 G2 box; other site 1305598004308 Switch I region; other site 1305598004309 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1305598004310 G3 box; other site 1305598004311 Switch II region; other site 1305598004312 GTP/Mg2+ binding site [chemical binding]; other site 1305598004313 G4 box; other site 1305598004314 G5 box; other site 1305598004315 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1305598004316 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1305598004317 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1305598004318 Cobalt transport protein component CbiN; Region: CbiN; cl00842 1305598004319 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1305598004320 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1305598004321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1305598004322 cell division protein GpsB; Provisional; Region: PRK14127 1305598004323 DivIVA domain; Region: DivI1A_domain; TIGR03544 1305598004324 hypothetical protein; Provisional; Region: PRK13660 1305598004325 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1305598004326 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1305598004327 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1305598004328 Transglycosylase; Region: Transgly; pfam00912 1305598004329 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1305598004330 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1305598004331 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1305598004332 minor groove reading motif; other site 1305598004333 helix-hairpin-helix signature motif; other site 1305598004334 substrate binding pocket [chemical binding]; other site 1305598004335 active site 1305598004336 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1305598004337 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1305598004338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1305598004339 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1305598004340 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1305598004341 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1305598004342 putative dimer interface [polypeptide binding]; other site 1305598004343 putative anticodon binding site; other site 1305598004344 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1305598004345 homodimer interface [polypeptide binding]; other site 1305598004346 motif 1; other site 1305598004347 motif 2; other site 1305598004348 active site 1305598004349 motif 3; other site 1305598004350 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1305598004351 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1305598004352 active site 1305598004353 catalytic site [active] 1305598004354 substrate binding site [chemical binding]; other site 1305598004355 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1305598004356 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1305598004357 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1305598004358 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1305598004359 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1305598004360 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1305598004361 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1305598004362 active site 1305598004363 NTP binding site [chemical binding]; other site 1305598004364 metal binding triad [ion binding]; metal-binding site 1305598004365 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1305598004366 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1305598004367 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1305598004368 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1305598004369 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1305598004370 homodimer interface [polypeptide binding]; other site 1305598004371 metal binding site [ion binding]; metal-binding site 1305598004372 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1305598004373 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1305598004374 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1305598004375 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1305598004376 UPF0302 domain; Region: UPF0302; pfam08864 1305598004377 A short protein domain of unknown function; Region: IDEAL; smart00914 1305598004378 TPR repeat; Region: TPR_11; pfam13414 1305598004379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1305598004380 binding surface 1305598004381 TPR motif; other site 1305598004382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1305598004383 TPR motif; other site 1305598004384 binding surface 1305598004385 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1305598004386 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1305598004387 hinge; other site 1305598004388 active site 1305598004389 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1305598004390 active site 1305598004391 NAD binding site [chemical binding]; other site 1305598004392 metal binding site [ion binding]; metal-binding site 1305598004393 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1305598004394 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1305598004395 Tetramer interface [polypeptide binding]; other site 1305598004396 active site 1305598004397 FMN-binding site [chemical binding]; other site 1305598004398 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1305598004399 active site 1305598004400 multimer interface [polypeptide binding]; other site 1305598004401 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1305598004402 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1305598004403 substrate binding pocket [chemical binding]; other site 1305598004404 chain length determination region; other site 1305598004405 substrate-Mg2+ binding site; other site 1305598004406 catalytic residues [active] 1305598004407 aspartate-rich region 1; other site 1305598004408 active site lid residues [active] 1305598004409 aspartate-rich region 2; other site 1305598004410 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1305598004411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598004412 S-adenosylmethionine binding site [chemical binding]; other site 1305598004413 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1305598004414 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1305598004415 IHF dimer interface [polypeptide binding]; other site 1305598004416 IHF - DNA interface [nucleotide binding]; other site 1305598004417 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1305598004418 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1305598004419 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1305598004420 GTP-binding protein Der; Reviewed; Region: PRK00093 1305598004421 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1305598004422 G1 box; other site 1305598004423 GTP/Mg2+ binding site [chemical binding]; other site 1305598004424 Switch I region; other site 1305598004425 G2 box; other site 1305598004426 Switch II region; other site 1305598004427 G3 box; other site 1305598004428 G4 box; other site 1305598004429 G5 box; other site 1305598004430 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1305598004431 G1 box; other site 1305598004432 GTP/Mg2+ binding site [chemical binding]; other site 1305598004433 Switch I region; other site 1305598004434 G2 box; other site 1305598004435 G3 box; other site 1305598004436 Switch II region; other site 1305598004437 G4 box; other site 1305598004438 G5 box; other site 1305598004439 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1305598004440 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1305598004441 RNA binding site [nucleotide binding]; other site 1305598004442 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1305598004443 RNA binding site [nucleotide binding]; other site 1305598004444 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1305598004445 RNA binding site [nucleotide binding]; other site 1305598004446 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1305598004447 RNA binding site [nucleotide binding]; other site 1305598004448 cytidylate kinase; Provisional; Region: cmk; PRK00023 1305598004449 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1305598004450 CMP-binding site; other site 1305598004451 The sites determining sugar specificity; other site 1305598004452 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1305598004453 active site 1305598004454 homotetramer interface [polypeptide binding]; other site 1305598004455 homodimer interface [polypeptide binding]; other site 1305598004456 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1305598004457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1305598004458 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598004459 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1305598004460 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1305598004461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1305598004462 ATP binding site [chemical binding]; other site 1305598004463 putative Mg++ binding site [ion binding]; other site 1305598004464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1305598004465 nucleotide binding region [chemical binding]; other site 1305598004466 ATP-binding site [chemical binding]; other site 1305598004467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1305598004468 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1305598004469 Predicted membrane protein [Function unknown]; Region: COG3601 1305598004470 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1305598004471 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1305598004472 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1305598004473 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1305598004474 CHAP domain; Region: CHAP; pfam05257 1305598004475 Small integral membrane protein [Function unknown]; Region: COG5546 1305598004476 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 1305598004477 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1305598004478 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 1305598004479 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1305598004480 hypothetical protein; Provisional; Region: PRK05926 1305598004481 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1305598004482 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1305598004483 Phage tail protein; Region: Sipho_tail; pfam05709 1305598004484 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 1305598004485 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1305598004486 linker region; other site 1305598004487 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1305598004488 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1305598004489 dimer interface [polypeptide binding]; other site 1305598004490 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1305598004491 Peptidase family M23; Region: Peptidase_M23; pfam01551 1305598004492 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1305598004493 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1305598004494 catalytic residue [active] 1305598004495 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1305598004496 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1305598004497 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1305598004498 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1305598004499 oligomerization interface [polypeptide binding]; other site 1305598004500 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1305598004501 Phage capsid family; Region: Phage_capsid; pfam05065 1305598004502 Clp protease; Region: CLP_protease; pfam00574 1305598004503 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1305598004504 oligomer interface [polypeptide binding]; other site 1305598004505 active site residues [active] 1305598004506 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1305598004507 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1305598004508 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1305598004509 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1305598004510 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1305598004511 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1305598004512 active site 1305598004513 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1305598004514 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1305598004515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1305598004516 ATP binding site [chemical binding]; other site 1305598004517 putative Mg++ binding site [ion binding]; other site 1305598004518 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1305598004519 VRR-NUC domain; Region: VRR_NUC; pfam08774 1305598004520 Virulence-associated protein E; Region: VirE; pfam05272 1305598004521 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1305598004522 Transcriptional activator RinB; Region: RinB; pfam06116 1305598004523 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 1305598004524 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1305598004525 dUTPase; Region: dUTPase_2; pfam08761 1305598004526 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1305598004527 active site 1305598004528 homodimer interface [polypeptide binding]; other site 1305598004529 metal binding site [ion binding]; metal-binding site 1305598004530 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1305598004531 YopX protein; Region: YopX; pfam09643 1305598004532 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1305598004533 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1305598004534 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1305598004535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1305598004536 non-specific DNA binding site [nucleotide binding]; other site 1305598004537 salt bridge; other site 1305598004538 sequence-specific DNA binding site [nucleotide binding]; other site 1305598004539 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 1305598004540 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 1305598004541 active site 1305598004542 DNA binding site [nucleotide binding] 1305598004543 catalytic site [active] 1305598004544 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1305598004545 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1305598004546 Homeodomain-like domain; Region: HTH_23; pfam13384 1305598004547 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1305598004548 BRO family, N-terminal domain; Region: Bro-N; smart01040 1305598004549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1305598004550 non-specific DNA binding site [nucleotide binding]; other site 1305598004551 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1305598004552 salt bridge; other site 1305598004553 sequence-specific DNA binding site [nucleotide binding]; other site 1305598004554 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1305598004555 Catalytic site [active] 1305598004556 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1305598004557 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1305598004558 active site 1305598004559 catalytic site [active] 1305598004560 substrate binding site [chemical binding]; other site 1305598004561 breast cancer carboxy-terminal domain; Region: BRCT; smart00292 1305598004562 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1305598004563 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1305598004564 Int/Topo IB signature motif; other site 1305598004565 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1305598004566 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1305598004567 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1305598004568 dimerization interface [polypeptide binding]; other site 1305598004569 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1305598004570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1305598004571 dimer interface [polypeptide binding]; other site 1305598004572 phosphorylation site [posttranslational modification] 1305598004573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598004574 ATP binding site [chemical binding]; other site 1305598004575 Mg2+ binding site [ion binding]; other site 1305598004576 G-X-G motif; other site 1305598004577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1305598004578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598004579 active site 1305598004580 phosphorylation site [posttranslational modification] 1305598004581 intermolecular recognition site; other site 1305598004582 dimerization interface [polypeptide binding]; other site 1305598004583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1305598004584 DNA binding site [nucleotide binding] 1305598004585 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1305598004586 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1305598004587 RNA binding surface [nucleotide binding]; other site 1305598004588 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1305598004589 active site 1305598004590 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1305598004591 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1305598004592 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1305598004593 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1305598004594 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1305598004595 active site 1305598004596 Int/Topo IB signature motif; other site 1305598004597 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1305598004598 metal binding site 2 [ion binding]; metal-binding site 1305598004599 putative DNA binding helix; other site 1305598004600 metal binding site 1 [ion binding]; metal-binding site 1305598004601 dimer interface [polypeptide binding]; other site 1305598004602 structural Zn2+ binding site [ion binding]; other site 1305598004603 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1305598004604 dimer interface [polypeptide binding]; other site 1305598004605 ADP-ribose binding site [chemical binding]; other site 1305598004606 active site 1305598004607 nudix motif; other site 1305598004608 metal binding site [ion binding]; metal-binding site 1305598004609 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1305598004610 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1305598004611 active site 1305598004612 catalytic tetrad [active] 1305598004613 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1305598004614 classical (c) SDRs; Region: SDR_c; cd05233 1305598004615 NAD(P) binding site [chemical binding]; other site 1305598004616 active site 1305598004617 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1305598004618 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1305598004619 ribonuclease Z; Region: RNase_Z; TIGR02651 1305598004620 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1305598004621 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1305598004622 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1305598004623 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1305598004624 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1305598004625 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1305598004626 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1305598004627 Ca binding site [ion binding]; other site 1305598004628 active site 1305598004629 catalytic site [active] 1305598004630 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1305598004631 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1305598004632 DNA binding site [nucleotide binding] 1305598004633 domain linker motif; other site 1305598004634 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1305598004635 putative ligand binding site [chemical binding]; other site 1305598004636 putative dimerization interface [polypeptide binding]; other site 1305598004637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1305598004638 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1305598004639 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1305598004640 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1305598004641 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1305598004642 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1305598004643 peptidase T-like protein; Region: PepT-like; TIGR01883 1305598004644 metal binding site [ion binding]; metal-binding site 1305598004645 putative dimer interface [polypeptide binding]; other site 1305598004646 Predicted membrane protein [Function unknown]; Region: COG4129 1305598004647 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1305598004648 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1305598004649 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1305598004650 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1305598004651 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1305598004652 E3 interaction surface; other site 1305598004653 lipoyl attachment site [posttranslational modification]; other site 1305598004654 e3 binding domain; Region: E3_binding; pfam02817 1305598004655 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1305598004656 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1305598004657 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1305598004658 alpha subunit interface [polypeptide binding]; other site 1305598004659 TPP binding site [chemical binding]; other site 1305598004660 heterodimer interface [polypeptide binding]; other site 1305598004661 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1305598004662 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1305598004663 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1305598004664 tetramer interface [polypeptide binding]; other site 1305598004665 TPP-binding site [chemical binding]; other site 1305598004666 heterodimer interface [polypeptide binding]; other site 1305598004667 phosphorylation loop region [posttranslational modification] 1305598004668 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1305598004669 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1305598004670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598004671 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1305598004672 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1305598004673 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1305598004674 Walker A/P-loop; other site 1305598004675 ATP binding site [chemical binding]; other site 1305598004676 Q-loop/lid; other site 1305598004677 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1305598004678 ABC transporter signature motif; other site 1305598004679 Walker B; other site 1305598004680 D-loop; other site 1305598004681 H-loop/switch region; other site 1305598004682 arginine repressor; Provisional; Region: PRK04280 1305598004683 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1305598004684 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1305598004685 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1305598004686 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1305598004687 substrate binding pocket [chemical binding]; other site 1305598004688 chain length determination region; other site 1305598004689 substrate-Mg2+ binding site; other site 1305598004690 catalytic residues [active] 1305598004691 aspartate-rich region 1; other site 1305598004692 active site lid residues [active] 1305598004693 aspartate-rich region 2; other site 1305598004694 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1305598004695 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1305598004696 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1305598004697 generic binding surface II; other site 1305598004698 generic binding surface I; other site 1305598004699 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1305598004700 putative RNA binding site [nucleotide binding]; other site 1305598004701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1305598004702 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1305598004703 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1305598004704 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1305598004705 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1305598004706 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1305598004707 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1305598004708 carboxyltransferase (CT) interaction site; other site 1305598004709 biotinylation site [posttranslational modification]; other site 1305598004710 elongation factor P; Validated; Region: PRK00529 1305598004711 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1305598004712 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1305598004713 RNA binding site [nucleotide binding]; other site 1305598004714 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1305598004715 RNA binding site [nucleotide binding]; other site 1305598004716 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1305598004717 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1305598004718 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1305598004719 active site 1305598004720 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1305598004721 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1305598004722 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1305598004723 active site residue [active] 1305598004724 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1305598004725 tetramer interface [polypeptide binding]; other site 1305598004726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598004727 catalytic residue [active] 1305598004728 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1305598004729 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1305598004730 tetramer interface [polypeptide binding]; other site 1305598004731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598004732 catalytic residue [active] 1305598004733 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1305598004734 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1305598004735 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1305598004736 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1305598004737 ADP binding site [chemical binding]; other site 1305598004738 magnesium binding site [ion binding]; other site 1305598004739 putative shikimate binding site; other site 1305598004740 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1305598004741 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1305598004742 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1305598004743 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1305598004744 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1305598004745 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1305598004746 Type II/IV secretion system protein; Region: T2SE; pfam00437 1305598004747 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1305598004748 Walker A motif; other site 1305598004749 ATP binding site [chemical binding]; other site 1305598004750 Walker B motif; other site 1305598004751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1305598004752 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1305598004753 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1305598004754 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1305598004755 Rhomboid family; Region: Rhomboid; pfam01694 1305598004756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1305598004757 binding surface 1305598004758 TPR motif; other site 1305598004759 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1305598004760 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1305598004761 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1305598004762 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1305598004763 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1305598004764 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1305598004765 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1305598004766 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1305598004767 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1305598004768 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1305598004769 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1305598004770 metal binding site 2 [ion binding]; metal-binding site 1305598004771 putative DNA binding helix; other site 1305598004772 metal binding site 1 [ion binding]; metal-binding site 1305598004773 dimer interface [polypeptide binding]; other site 1305598004774 structural Zn2+ binding site [ion binding]; other site 1305598004775 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1305598004776 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598004777 ABC-ATPase subunit interface; other site 1305598004778 dimer interface [polypeptide binding]; other site 1305598004779 putative PBP binding regions; other site 1305598004780 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1305598004781 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1305598004782 endonuclease IV; Provisional; Region: PRK01060 1305598004783 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1305598004784 AP (apurinic/apyrimidinic) site pocket; other site 1305598004785 DNA interaction; other site 1305598004786 Metal-binding active site; metal-binding site 1305598004787 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1305598004788 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1305598004789 ATP binding site [chemical binding]; other site 1305598004790 Mg++ binding site [ion binding]; other site 1305598004791 motif III; other site 1305598004792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1305598004793 nucleotide binding region [chemical binding]; other site 1305598004794 ATP-binding site [chemical binding]; other site 1305598004795 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1305598004796 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1305598004797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1305598004798 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1305598004799 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1305598004800 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1305598004801 Family of unknown function (DUF633); Region: DUF633; pfam04816 1305598004802 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1305598004803 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1305598004804 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1305598004805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1305598004806 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1305598004807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1305598004808 DNA binding residues [nucleotide binding] 1305598004809 DNA primase, catalytic core; Region: dnaG; TIGR01391 1305598004810 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1305598004811 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1305598004812 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1305598004813 active site 1305598004814 metal binding site [ion binding]; metal-binding site 1305598004815 interdomain interaction site; other site 1305598004816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1305598004817 HTH domain; Region: HTH_11; cl17392 1305598004818 FOG: CBS domain [General function prediction only]; Region: COG0517 1305598004819 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1305598004820 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1305598004821 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1305598004822 motif 1; other site 1305598004823 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1305598004824 active site 1305598004825 motif 2; other site 1305598004826 motif 3; other site 1305598004827 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1305598004828 anticodon binding site; other site 1305598004829 DNA repair protein RecO; Region: reco; TIGR00613 1305598004830 Recombination protein O N terminal; Region: RecO_N; pfam11967 1305598004831 Recombination protein O C terminal; Region: RecO_C; pfam02565 1305598004832 GTPase Era; Reviewed; Region: era; PRK00089 1305598004833 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1305598004834 G1 box; other site 1305598004835 GTP/Mg2+ binding site [chemical binding]; other site 1305598004836 Switch I region; other site 1305598004837 G2 box; other site 1305598004838 Switch II region; other site 1305598004839 G3 box; other site 1305598004840 G4 box; other site 1305598004841 G5 box; other site 1305598004842 KH domain; Region: KH_2; pfam07650 1305598004843 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1305598004844 active site 1305598004845 catalytic motif [active] 1305598004846 Zn binding site [ion binding]; other site 1305598004847 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1305598004848 metal-binding heat shock protein; Provisional; Region: PRK00016 1305598004849 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1305598004850 PhoH-like protein; Region: PhoH; pfam02562 1305598004851 hypothetical protein; Provisional; Region: PRK13665 1305598004852 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1305598004853 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1305598004854 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1305598004855 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1305598004856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1305598004857 FeS/SAM binding site; other site 1305598004858 TRAM domain; Region: TRAM; cl01282 1305598004859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1305598004860 RNA methyltransferase, RsmE family; Region: TIGR00046 1305598004861 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1305598004862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598004863 S-adenosylmethionine binding site [chemical binding]; other site 1305598004864 chaperone protein DnaJ; Provisional; Region: PRK14280 1305598004865 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1305598004866 HSP70 interaction site [polypeptide binding]; other site 1305598004867 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1305598004868 substrate binding site [polypeptide binding]; other site 1305598004869 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1305598004870 Zn binding sites [ion binding]; other site 1305598004871 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1305598004872 dimer interface [polypeptide binding]; other site 1305598004873 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1305598004874 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1305598004875 nucleotide binding site [chemical binding]; other site 1305598004876 NEF interaction site [polypeptide binding]; other site 1305598004877 SBD interface [polypeptide binding]; other site 1305598004878 heat shock protein GrpE; Provisional; Region: PRK14140 1305598004879 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1305598004880 dimer interface [polypeptide binding]; other site 1305598004881 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1305598004882 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1305598004883 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1305598004884 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 1305598004885 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1305598004886 FeS/SAM binding site; other site 1305598004887 HemN C-terminal domain; Region: HemN_C; pfam06969 1305598004888 GTP-binding protein LepA; Provisional; Region: PRK05433 1305598004889 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1305598004890 G1 box; other site 1305598004891 putative GEF interaction site [polypeptide binding]; other site 1305598004892 GTP/Mg2+ binding site [chemical binding]; other site 1305598004893 Switch I region; other site 1305598004894 G2 box; other site 1305598004895 G3 box; other site 1305598004896 Switch II region; other site 1305598004897 G4 box; other site 1305598004898 G5 box; other site 1305598004899 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1305598004900 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1305598004901 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1305598004902 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1305598004903 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1305598004904 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1305598004905 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1305598004906 Competence protein; Region: Competence; pfam03772 1305598004907 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1305598004908 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1305598004909 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1305598004910 catalytic motif [active] 1305598004911 Zn binding site [ion binding]; other site 1305598004912 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1305598004913 SLBB domain; Region: SLBB; pfam10531 1305598004914 Helix-hairpin-helix motif; Region: HHH; pfam00633 1305598004915 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1305598004916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598004917 S-adenosylmethionine binding site [chemical binding]; other site 1305598004918 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1305598004919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1305598004920 Zn2+ binding site [ion binding]; other site 1305598004921 Mg2+ binding site [ion binding]; other site 1305598004922 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1305598004923 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1305598004924 active site 1305598004925 (T/H)XGH motif; other site 1305598004926 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1305598004927 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1305598004928 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1305598004929 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1305598004930 shikimate binding site; other site 1305598004931 NAD(P) binding site [chemical binding]; other site 1305598004932 GTPase YqeH; Provisional; Region: PRK13796 1305598004933 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1305598004934 GTP/Mg2+ binding site [chemical binding]; other site 1305598004935 G4 box; other site 1305598004936 G5 box; other site 1305598004937 G1 box; other site 1305598004938 Switch I region; other site 1305598004939 G2 box; other site 1305598004940 G3 box; other site 1305598004941 Switch II region; other site 1305598004942 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1305598004943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598004944 active site 1305598004945 motif I; other site 1305598004946 motif II; other site 1305598004947 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1305598004948 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1305598004949 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1305598004950 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598004951 Fic family protein [Function unknown]; Region: COG3177 1305598004952 Fic/DOC family; Region: Fic; pfam02661 1305598004953 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1305598004954 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1305598004955 putative active site [active] 1305598004956 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1305598004957 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1305598004958 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1305598004959 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1305598004960 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1305598004961 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1305598004962 carboxyltransferase (CT) interaction site; other site 1305598004963 biotinylation site [posttranslational modification]; other site 1305598004964 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1305598004965 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1305598004966 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1305598004967 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1305598004968 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1305598004969 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1305598004970 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1305598004971 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1305598004972 Sugar specificity; other site 1305598004973 Pyrimidine base specificity; other site 1305598004974 ATP-binding site [chemical binding]; other site 1305598004975 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1305598004976 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1305598004977 Peptidase family U32; Region: Peptidase_U32; pfam01136 1305598004978 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1305598004979 Peptidase family U32; Region: Peptidase_U32; pfam01136 1305598004980 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1305598004981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598004982 S-adenosylmethionine binding site [chemical binding]; other site 1305598004983 hypothetical protein; Provisional; Region: PRK13678 1305598004984 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1305598004985 hypothetical protein; Provisional; Region: PRK05473 1305598004986 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1305598004987 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1305598004988 motif 1; other site 1305598004989 active site 1305598004990 motif 2; other site 1305598004991 motif 3; other site 1305598004992 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1305598004993 DHHA1 domain; Region: DHHA1; pfam02272 1305598004994 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1305598004995 AAA domain; Region: AAA_30; pfam13604 1305598004996 Family description; Region: UvrD_C_2; pfam13538 1305598004997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1305598004998 binding surface 1305598004999 TPR motif; other site 1305598005000 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1305598005001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1305598005002 binding surface 1305598005003 TPR motif; other site 1305598005004 TPR repeat; Region: TPR_11; pfam13414 1305598005005 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1305598005006 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1305598005007 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1305598005008 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1305598005009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1305598005010 catalytic residue [active] 1305598005011 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1305598005012 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1305598005013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1305598005014 Predicted transcriptional regulator [Transcription]; Region: COG1959 1305598005015 Transcriptional regulator; Region: Rrf2; pfam02082 1305598005016 recombination factor protein RarA; Reviewed; Region: PRK13342 1305598005017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598005018 Walker A motif; other site 1305598005019 ATP binding site [chemical binding]; other site 1305598005020 Walker B motif; other site 1305598005021 arginine finger; other site 1305598005022 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1305598005023 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1305598005024 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1305598005025 putative ATP binding site [chemical binding]; other site 1305598005026 putative substrate interface [chemical binding]; other site 1305598005027 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1305598005028 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1305598005029 dimer interface [polypeptide binding]; other site 1305598005030 anticodon binding site; other site 1305598005031 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1305598005032 homodimer interface [polypeptide binding]; other site 1305598005033 motif 1; other site 1305598005034 active site 1305598005035 motif 2; other site 1305598005036 GAD domain; Region: GAD; pfam02938 1305598005037 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1305598005038 motif 3; other site 1305598005039 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1305598005040 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1305598005041 dimer interface [polypeptide binding]; other site 1305598005042 motif 1; other site 1305598005043 active site 1305598005044 motif 2; other site 1305598005045 motif 3; other site 1305598005046 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1305598005047 anticodon binding site; other site 1305598005048 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1305598005049 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1305598005050 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1305598005051 active site 1305598005052 metal binding site [ion binding]; metal-binding site 1305598005053 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1305598005054 putative active site [active] 1305598005055 dimerization interface [polypeptide binding]; other site 1305598005056 putative tRNAtyr binding site [nucleotide binding]; other site 1305598005057 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1305598005058 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1305598005059 Zn2+ binding site [ion binding]; other site 1305598005060 Mg2+ binding site [ion binding]; other site 1305598005061 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1305598005062 synthetase active site [active] 1305598005063 NTP binding site [chemical binding]; other site 1305598005064 metal binding site [ion binding]; metal-binding site 1305598005065 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1305598005066 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1305598005067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1305598005068 active site 1305598005069 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1305598005070 DHH family; Region: DHH; pfam01368 1305598005071 DHHA1 domain; Region: DHHA1; pfam02272 1305598005072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1305598005073 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1305598005074 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1305598005075 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1305598005076 Protein export membrane protein; Region: SecD_SecF; pfam02355 1305598005077 Preprotein translocase subunit; Region: YajC; pfam02699 1305598005078 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1305598005079 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1305598005080 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1305598005081 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1305598005082 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1305598005083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598005084 Walker A motif; other site 1305598005085 ATP binding site [chemical binding]; other site 1305598005086 Walker B motif; other site 1305598005087 arginine finger; other site 1305598005088 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1305598005089 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1305598005090 RuvA N terminal domain; Region: RuvA_N; pfam01330 1305598005091 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1305598005092 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 1305598005093 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1305598005094 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1305598005095 GTP1/OBG; Region: GTP1_OBG; pfam01018 1305598005096 Obg GTPase; Region: Obg; cd01898 1305598005097 G1 box; other site 1305598005098 GTP/Mg2+ binding site [chemical binding]; other site 1305598005099 Switch I region; other site 1305598005100 G2 box; other site 1305598005101 G3 box; other site 1305598005102 Switch II region; other site 1305598005103 G4 box; other site 1305598005104 G5 box; other site 1305598005105 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1305598005106 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1305598005107 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1305598005108 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1305598005109 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1305598005110 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1305598005111 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1305598005112 rod shape-determining protein MreC; Region: MreC; pfam04085 1305598005113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598005114 S-adenosylmethionine binding site [chemical binding]; other site 1305598005115 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1305598005116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598005117 S-adenosylmethionine binding site [chemical binding]; other site 1305598005118 aminoglycoside resistance protein; Provisional; Region: PRK13746 1305598005119 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1305598005120 active site 1305598005121 NTP binding site [chemical binding]; other site 1305598005122 metal binding triad [ion binding]; metal-binding site 1305598005123 antibiotic binding site [chemical binding]; other site 1305598005124 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1305598005125 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1305598005126 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1305598005127 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 1305598005128 Int/Topo IB signature motif; other site 1305598005129 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1305598005130 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1305598005131 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 1305598005132 Int/Topo IB signature motif; other site 1305598005133 hypothetical protein; Reviewed; Region: PRK00024 1305598005134 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1305598005135 MPN+ (JAMM) motif; other site 1305598005136 Zinc-binding site [ion binding]; other site 1305598005137 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1305598005138 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1305598005139 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1305598005140 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1305598005141 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1305598005142 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1305598005143 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1305598005144 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1305598005145 active site 1305598005146 HIGH motif; other site 1305598005147 nucleotide binding site [chemical binding]; other site 1305598005148 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1305598005149 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1305598005150 active site 1305598005151 KMSKS motif; other site 1305598005152 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1305598005153 tRNA binding surface [nucleotide binding]; other site 1305598005154 anticodon binding site; other site 1305598005155 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1305598005156 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1305598005157 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1305598005158 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1305598005159 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1305598005160 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1305598005161 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1305598005162 inhibitor-cofactor binding pocket; inhibition site 1305598005163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598005164 catalytic residue [active] 1305598005165 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1305598005166 dimer interface [polypeptide binding]; other site 1305598005167 active site 1305598005168 Schiff base residues; other site 1305598005169 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1305598005170 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1305598005171 active site 1305598005172 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1305598005173 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1305598005174 domain interfaces; other site 1305598005175 active site 1305598005176 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 1305598005177 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1305598005178 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1305598005179 tRNA; other site 1305598005180 putative tRNA binding site [nucleotide binding]; other site 1305598005181 putative NADP binding site [chemical binding]; other site 1305598005182 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1305598005183 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1305598005184 G1 box; other site 1305598005185 GTP/Mg2+ binding site [chemical binding]; other site 1305598005186 Switch I region; other site 1305598005187 G2 box; other site 1305598005188 G3 box; other site 1305598005189 Switch II region; other site 1305598005190 G4 box; other site 1305598005191 G5 box; other site 1305598005192 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1305598005193 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1305598005194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598005195 Walker A motif; other site 1305598005196 ATP binding site [chemical binding]; other site 1305598005197 Walker B motif; other site 1305598005198 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1305598005199 trigger factor; Provisional; Region: tig; PRK01490 1305598005200 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1305598005201 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1305598005202 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1305598005203 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1305598005204 23S rRNA binding site [nucleotide binding]; other site 1305598005205 L21 binding site [polypeptide binding]; other site 1305598005206 L13 binding site [polypeptide binding]; other site 1305598005207 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1305598005208 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1305598005209 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1305598005210 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1305598005211 lysine transporter; Provisional; Region: PRK10836 1305598005212 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1305598005213 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1305598005214 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1305598005215 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1305598005216 active site 1305598005217 dimer interface [polypeptide binding]; other site 1305598005218 motif 1; other site 1305598005219 motif 2; other site 1305598005220 motif 3; other site 1305598005221 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1305598005222 anticodon binding site; other site 1305598005223 primosomal protein DnaI; Reviewed; Region: PRK08939 1305598005224 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1305598005225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598005226 Walker A motif; other site 1305598005227 ATP binding site [chemical binding]; other site 1305598005228 Walker B motif; other site 1305598005229 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1305598005230 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1305598005231 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1305598005232 ATP cone domain; Region: ATP-cone; pfam03477 1305598005233 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1305598005234 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1305598005235 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1305598005236 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1305598005237 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1305598005238 CoA-binding site [chemical binding]; other site 1305598005239 ATP-binding [chemical binding]; other site 1305598005240 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1305598005241 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1305598005242 DNA binding site [nucleotide binding] 1305598005243 catalytic residue [active] 1305598005244 H2TH interface [polypeptide binding]; other site 1305598005245 putative catalytic residues [active] 1305598005246 turnover-facilitating residue; other site 1305598005247 intercalation triad [nucleotide binding]; other site 1305598005248 8OG recognition residue [nucleotide binding]; other site 1305598005249 putative reading head residues; other site 1305598005250 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1305598005251 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1305598005252 DNA polymerase I; Provisional; Region: PRK05755 1305598005253 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1305598005254 active site 1305598005255 metal binding site 1 [ion binding]; metal-binding site 1305598005256 putative 5' ssDNA interaction site; other site 1305598005257 metal binding site 3; metal-binding site 1305598005258 metal binding site 2 [ion binding]; metal-binding site 1305598005259 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1305598005260 putative DNA binding site [nucleotide binding]; other site 1305598005261 putative metal binding site [ion binding]; other site 1305598005262 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1305598005263 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1305598005264 active site 1305598005265 DNA binding site [nucleotide binding] 1305598005266 catalytic site [active] 1305598005267 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1305598005268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1305598005269 dimer interface [polypeptide binding]; other site 1305598005270 phosphorylation site [posttranslational modification] 1305598005271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598005272 ATP binding site [chemical binding]; other site 1305598005273 Mg2+ binding site [ion binding]; other site 1305598005274 G-X-G motif; other site 1305598005275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1305598005276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598005277 active site 1305598005278 phosphorylation site [posttranslational modification] 1305598005279 intermolecular recognition site; other site 1305598005280 dimerization interface [polypeptide binding]; other site 1305598005281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1305598005282 DNA binding site [nucleotide binding] 1305598005283 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1305598005284 isocitrate dehydrogenase; Validated; Region: PRK07362 1305598005285 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1305598005286 dimer interface [polypeptide binding]; other site 1305598005287 Citrate synthase; Region: Citrate_synt; pfam00285 1305598005288 active site 1305598005289 citrylCoA binding site [chemical binding]; other site 1305598005290 oxalacetate/citrate binding site [chemical binding]; other site 1305598005291 coenzyme A binding site [chemical binding]; other site 1305598005292 catalytic triad [active] 1305598005293 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1305598005294 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1305598005295 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1305598005296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598005297 pyruvate kinase; Provisional; Region: PRK06354 1305598005298 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1305598005299 domain interfaces; other site 1305598005300 active site 1305598005301 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1305598005302 6-phosphofructokinase; Provisional; Region: PRK03202 1305598005303 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1305598005304 active site 1305598005305 ADP/pyrophosphate binding site [chemical binding]; other site 1305598005306 dimerization interface [polypeptide binding]; other site 1305598005307 allosteric effector site; other site 1305598005308 fructose-1,6-bisphosphate binding site; other site 1305598005309 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1305598005310 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1305598005311 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1305598005312 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1305598005313 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1305598005314 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1305598005315 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1305598005316 putative NAD(P) binding site [chemical binding]; other site 1305598005317 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1305598005318 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1305598005319 active site 1305598005320 PHP Thumb interface [polypeptide binding]; other site 1305598005321 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1305598005322 generic binding surface I; other site 1305598005323 generic binding surface II; other site 1305598005324 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1305598005325 DHH family; Region: DHH; pfam01368 1305598005326 DHHA1 domain; Region: DHHA1; pfam02272 1305598005327 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1305598005328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1305598005329 DNA-binding site [nucleotide binding]; DNA binding site 1305598005330 DRTGG domain; Region: DRTGG; pfam07085 1305598005331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1305598005332 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1305598005333 active site 2 [active] 1305598005334 active site 1 [active] 1305598005335 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1305598005336 Ligand Binding Site [chemical binding]; other site 1305598005337 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1305598005338 metal-dependent hydrolase; Provisional; Region: PRK00685 1305598005339 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1305598005340 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1305598005341 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1305598005342 active site 1305598005343 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1305598005344 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1305598005345 hexamer interface [polypeptide binding]; other site 1305598005346 ligand binding site [chemical binding]; other site 1305598005347 putative active site [active] 1305598005348 NAD(P) binding site [chemical binding]; other site 1305598005349 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1305598005350 Ligand Binding Site [chemical binding]; other site 1305598005351 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1305598005352 propionate/acetate kinase; Provisional; Region: PRK12379 1305598005353 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1305598005354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598005355 S-adenosylmethionine binding site [chemical binding]; other site 1305598005356 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1305598005357 dimer interface [polypeptide binding]; other site 1305598005358 catalytic triad [active] 1305598005359 peroxidatic and resolving cysteines [active] 1305598005360 hypothetical protein; Provisional; Region: PRK10621 1305598005361 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1305598005362 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1305598005363 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1305598005364 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1305598005365 Ligand Binding Site [chemical binding]; other site 1305598005366 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1305598005367 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1305598005368 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1305598005369 catalytic residue [active] 1305598005370 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1305598005371 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1305598005372 GAF domain; Region: GAF_2; pfam13185 1305598005373 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1305598005374 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1305598005375 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1305598005376 RNA binding surface [nucleotide binding]; other site 1305598005377 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1305598005378 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1305598005379 active site 1305598005380 catalytic site [active] 1305598005381 OsmC-like protein; Region: OsmC; cl00767 1305598005382 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1305598005383 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1305598005384 catalytic residue [active] 1305598005385 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1305598005386 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1305598005387 ligand binding site [chemical binding]; other site 1305598005388 NAD binding site [chemical binding]; other site 1305598005389 dimerization interface [polypeptide binding]; other site 1305598005390 catalytic site [active] 1305598005391 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1305598005392 putative L-serine binding site [chemical binding]; other site 1305598005393 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1305598005394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598005395 motif II; other site 1305598005396 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1305598005397 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1305598005398 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1305598005399 active site turn [active] 1305598005400 phosphorylation site [posttranslational modification] 1305598005401 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1305598005402 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1305598005403 putative acyl-acceptor binding pocket; other site 1305598005404 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1305598005405 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1305598005406 protein binding site [polypeptide binding]; other site 1305598005407 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1305598005408 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1305598005409 active site 1305598005410 HIGH motif; other site 1305598005411 dimer interface [polypeptide binding]; other site 1305598005412 KMSKS motif; other site 1305598005413 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1305598005414 RNA binding surface [nucleotide binding]; other site 1305598005415 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1305598005416 Transglycosylase; Region: Transgly; pfam00912 1305598005417 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 1305598005418 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1305598005419 NEAr Transporter domain; Region: NEAT; smart00725 1305598005420 NEAr Transporter domain; Region: NEAT; smart00725 1305598005421 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1305598005422 heme-binding site [chemical binding]; other site 1305598005423 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1305598005424 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1305598005425 Potassium binding sites [ion binding]; other site 1305598005426 Cesium cation binding sites [ion binding]; other site 1305598005427 acetyl-CoA synthetase; Provisional; Region: PRK04319 1305598005428 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1305598005429 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1305598005430 active site 1305598005431 acyl-activating enzyme (AAE) consensus motif; other site 1305598005432 putative CoA binding site [chemical binding]; other site 1305598005433 AMP binding site [chemical binding]; other site 1305598005434 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1305598005435 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1305598005436 active site 1305598005437 Zn binding site [ion binding]; other site 1305598005438 catabolite control protein A; Region: ccpA; TIGR01481 1305598005439 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1305598005440 DNA binding site [nucleotide binding] 1305598005441 domain linker motif; other site 1305598005442 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1305598005443 dimerization interface [polypeptide binding]; other site 1305598005444 effector binding site; other site 1305598005445 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1305598005446 Chorismate mutase type II; Region: CM_2; cl00693 1305598005447 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1305598005448 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1305598005449 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1305598005450 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1305598005451 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1305598005452 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1305598005453 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1305598005454 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1305598005455 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1305598005456 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1305598005457 putative tRNA-binding site [nucleotide binding]; other site 1305598005458 hypothetical protein; Provisional; Region: PRK13668 1305598005459 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1305598005460 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1305598005461 catalytic residues [active] 1305598005462 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1305598005463 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1305598005464 oligomer interface [polypeptide binding]; other site 1305598005465 active site 1305598005466 metal binding site [ion binding]; metal-binding site 1305598005467 Predicted small secreted protein [Function unknown]; Region: COG5584 1305598005468 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1305598005469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598005470 S-adenosylmethionine binding site [chemical binding]; other site 1305598005471 Phosphotransferase enzyme family; Region: APH; pfam01636 1305598005472 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1305598005473 active site 1305598005474 substrate binding site [chemical binding]; other site 1305598005475 ATP binding site [chemical binding]; other site 1305598005476 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1305598005477 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1305598005478 homodimer interface [polypeptide binding]; other site 1305598005479 substrate-cofactor binding pocket; other site 1305598005480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598005481 catalytic residue [active] 1305598005482 dipeptidase PepV; Reviewed; Region: PRK07318 1305598005483 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1305598005484 active site 1305598005485 metal binding site [ion binding]; metal-binding site 1305598005486 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1305598005487 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1305598005488 RNA binding surface [nucleotide binding]; other site 1305598005489 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1305598005490 active site 1305598005491 uracil binding [chemical binding]; other site 1305598005492 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1305598005493 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1305598005494 HI0933-like protein; Region: HI0933_like; pfam03486 1305598005495 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598005496 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1305598005497 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005498 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005499 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005500 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005501 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005502 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005503 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005504 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005505 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005506 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005507 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005508 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005509 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005510 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598005511 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1305598005512 active site residue [active] 1305598005513 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1305598005514 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1305598005515 HIGH motif; other site 1305598005516 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1305598005517 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1305598005518 active site 1305598005519 KMSKS motif; other site 1305598005520 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1305598005521 tRNA binding surface [nucleotide binding]; other site 1305598005522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1305598005523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598005524 putative substrate translocation pore; other site 1305598005525 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1305598005526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598005527 S-adenosylmethionine binding site [chemical binding]; other site 1305598005528 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598005529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598005530 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1305598005531 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1305598005532 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1305598005533 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1305598005534 homopentamer interface [polypeptide binding]; other site 1305598005535 active site 1305598005536 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1305598005537 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1305598005538 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1305598005539 dimerization interface [polypeptide binding]; other site 1305598005540 active site 1305598005541 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1305598005542 Lumazine binding domain; Region: Lum_binding; pfam00677 1305598005543 Lumazine binding domain; Region: Lum_binding; pfam00677 1305598005544 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1305598005545 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1305598005546 catalytic motif [active] 1305598005547 Zn binding site [ion binding]; other site 1305598005548 RibD C-terminal domain; Region: RibD_C; cl17279 1305598005549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1305598005550 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1305598005551 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1305598005552 arsenical pump membrane protein; Provisional; Region: PRK15445 1305598005553 transmembrane helices; other site 1305598005554 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1305598005555 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1305598005556 active site 1305598005557 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1305598005558 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1305598005559 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1305598005560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1305598005561 DNA binding residues [nucleotide binding] 1305598005562 CAAX protease self-immunity; Region: Abi; pfam02517 1305598005563 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1305598005564 active site 1305598005565 intersubunit interactions; other site 1305598005566 catalytic residue [active] 1305598005567 camphor resistance protein CrcB; Provisional; Region: PRK14201 1305598005568 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1305598005569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598005570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598005571 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1305598005572 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1305598005573 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1305598005574 active site 1305598005575 catalytic tetrad [active] 1305598005576 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1305598005577 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1305598005578 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1305598005579 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1305598005580 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1305598005581 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1305598005582 active site 1305598005583 substrate-binding site [chemical binding]; other site 1305598005584 metal-binding site [ion binding] 1305598005585 ATP binding site [chemical binding]; other site 1305598005586 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1305598005587 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1305598005588 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1305598005589 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1305598005590 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1305598005591 nudix motif; other site 1305598005592 Haemolytic domain; Region: Haemolytic; pfam01809 1305598005593 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1305598005594 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1305598005595 metal binding site [ion binding]; metal-binding site 1305598005596 substrate binding pocket [chemical binding]; other site 1305598005597 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1305598005598 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1305598005599 acyl-activating enzyme (AAE) consensus motif; other site 1305598005600 putative AMP binding site [chemical binding]; other site 1305598005601 putative active site [active] 1305598005602 putative CoA binding site [chemical binding]; other site 1305598005603 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1305598005604 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1305598005605 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1305598005606 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1305598005607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1305598005608 Transposase; Region: HTH_Tnp_1; cl17663 1305598005609 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1305598005610 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1305598005611 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1305598005612 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1305598005613 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1305598005614 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1305598005615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598005616 S-adenosylmethionine binding site [chemical binding]; other site 1305598005617 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1305598005618 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1305598005619 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1305598005620 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1305598005621 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1305598005622 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1305598005623 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1305598005624 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1305598005625 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1305598005626 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1305598005627 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1305598005628 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1305598005629 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1305598005630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598005631 Walker A/P-loop; other site 1305598005632 ATP binding site [chemical binding]; other site 1305598005633 Q-loop/lid; other site 1305598005634 ABC transporter signature motif; other site 1305598005635 Walker B; other site 1305598005636 D-loop; other site 1305598005637 H-loop/switch region; other site 1305598005638 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 1305598005639 active site 1305598005640 catalytic triad [active] 1305598005641 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1305598005642 Flavoprotein; Region: Flavoprotein; pfam02441 1305598005643 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1305598005644 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 1305598005645 active site 1305598005646 zinc binding site [ion binding]; other site 1305598005647 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1305598005648 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1305598005649 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1305598005650 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 1305598005651 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1305598005652 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1305598005653 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1305598005654 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 1305598005655 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1305598005656 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1305598005657 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1305598005658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1305598005659 ferrochelatase; Provisional; Region: PRK12435 1305598005660 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1305598005661 C-terminal domain interface [polypeptide binding]; other site 1305598005662 active site 1305598005663 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1305598005664 active site 1305598005665 N-terminal domain interface [polypeptide binding]; other site 1305598005666 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1305598005667 substrate binding site [chemical binding]; other site 1305598005668 active site 1305598005669 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1305598005670 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1305598005671 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1305598005672 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1305598005673 Walker A/P-loop; other site 1305598005674 ATP binding site [chemical binding]; other site 1305598005675 Q-loop/lid; other site 1305598005676 ABC transporter signature motif; other site 1305598005677 Walker B; other site 1305598005678 D-loop; other site 1305598005679 H-loop/switch region; other site 1305598005680 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1305598005681 HIT family signature motif; other site 1305598005682 catalytic residue [active] 1305598005683 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1305598005684 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1305598005685 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1305598005686 SurA N-terminal domain; Region: SurA_N_3; cl07813 1305598005687 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1305598005688 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1305598005689 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1305598005690 generic binding surface II; other site 1305598005691 generic binding surface I; other site 1305598005692 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1305598005693 Zn2+ binding site [ion binding]; other site 1305598005694 Mg2+ binding site [ion binding]; other site 1305598005695 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1305598005696 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1305598005697 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 1305598005698 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1305598005699 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1305598005700 active site 1305598005701 metal binding site [ion binding]; metal-binding site 1305598005702 DNA binding site [nucleotide binding] 1305598005703 hypothetical protein; Provisional; Region: PRK13676 1305598005704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1305598005705 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1305598005706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1305598005707 non-specific DNA binding site [nucleotide binding]; other site 1305598005708 salt bridge; other site 1305598005709 sequence-specific DNA binding site [nucleotide binding]; other site 1305598005710 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1305598005711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598005712 active site 1305598005713 phosphorylation site [posttranslational modification] 1305598005714 intermolecular recognition site; other site 1305598005715 dimerization interface [polypeptide binding]; other site 1305598005716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1305598005717 DNA binding residues [nucleotide binding] 1305598005718 dimerization interface [polypeptide binding]; other site 1305598005719 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1305598005720 GAF domain; Region: GAF_3; pfam13492 1305598005721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1305598005722 Histidine kinase; Region: HisKA_3; pfam07730 1305598005723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598005724 ATP binding site [chemical binding]; other site 1305598005725 Mg2+ binding site [ion binding]; other site 1305598005726 G-X-G motif; other site 1305598005727 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1305598005728 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1305598005729 active site 1305598005730 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1305598005731 Class II fumarases; Region: Fumarase_classII; cd01362 1305598005732 active site 1305598005733 tetramer interface [polypeptide binding]; other site 1305598005734 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1305598005735 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1305598005736 active site 1305598005737 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1305598005738 epoxyqueuosine reductase; Region: TIGR00276 1305598005739 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1305598005740 HEAT repeats; Region: HEAT_2; pfam13646 1305598005741 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1305598005742 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1305598005743 Walker A/P-loop; other site 1305598005744 ATP binding site [chemical binding]; other site 1305598005745 Q-loop/lid; other site 1305598005746 ABC transporter signature motif; other site 1305598005747 Walker B; other site 1305598005748 D-loop; other site 1305598005749 H-loop/switch region; other site 1305598005750 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1305598005751 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1305598005752 substrate binding pocket [chemical binding]; other site 1305598005753 membrane-bound complex binding site; other site 1305598005754 hinge residues; other site 1305598005755 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1305598005756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598005757 dimer interface [polypeptide binding]; other site 1305598005758 conserved gate region; other site 1305598005759 putative PBP binding loops; other site 1305598005760 ABC-ATPase subunit interface; other site 1305598005761 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1305598005762 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1305598005763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1305598005764 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1305598005765 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1305598005766 metal binding site 2 [ion binding]; metal-binding site 1305598005767 putative DNA binding helix; other site 1305598005768 metal binding site 1 [ion binding]; metal-binding site 1305598005769 dimer interface [polypeptide binding]; other site 1305598005770 structural Zn2+ binding site [ion binding]; other site 1305598005771 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1305598005772 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1305598005773 putative ligand binding site [chemical binding]; other site 1305598005774 NAD binding site [chemical binding]; other site 1305598005775 catalytic site [active] 1305598005776 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1305598005777 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1305598005778 catalytic triad [active] 1305598005779 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1305598005780 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1305598005781 inhibitor-cofactor binding pocket; inhibition site 1305598005782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598005783 catalytic residue [active] 1305598005784 Predicted membrane protein [Function unknown]; Region: COG4129 1305598005785 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1305598005786 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1305598005787 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1305598005788 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1305598005789 Walker A/P-loop; other site 1305598005790 ATP binding site [chemical binding]; other site 1305598005791 Q-loop/lid; other site 1305598005792 ABC transporter signature motif; other site 1305598005793 Walker B; other site 1305598005794 D-loop; other site 1305598005795 H-loop/switch region; other site 1305598005796 hypothetical protein; Provisional; Region: PRK13662 1305598005797 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1305598005798 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1305598005799 minor groove reading motif; other site 1305598005800 helix-hairpin-helix signature motif; other site 1305598005801 substrate binding pocket [chemical binding]; other site 1305598005802 active site 1305598005803 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1305598005804 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1305598005805 DNA binding and oxoG recognition site [nucleotide binding] 1305598005806 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1305598005807 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1305598005808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598005809 Walker A/P-loop; other site 1305598005810 ATP binding site [chemical binding]; other site 1305598005811 Q-loop/lid; other site 1305598005812 ABC transporter signature motif; other site 1305598005813 Walker B; other site 1305598005814 H-loop/switch region; other site 1305598005815 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1305598005816 recombination regulator RecX; Provisional; Region: recX; PRK14135 1305598005817 glycosyltransferase; Provisional; Region: PRK13481 1305598005818 Transglycosylase; Region: Transgly; pfam00912 1305598005819 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1305598005820 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1305598005821 proposed catalytic triad [active] 1305598005822 conserved cys residue [active] 1305598005823 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1305598005824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1305598005825 FeS/SAM binding site; other site 1305598005826 YfkB-like domain; Region: YfkB; pfam08756 1305598005827 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1305598005828 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1305598005829 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1305598005830 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1305598005831 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1305598005832 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1305598005833 active site 1305598005834 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1305598005835 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1305598005836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598005837 active site 1305598005838 phosphorylation site [posttranslational modification] 1305598005839 intermolecular recognition site; other site 1305598005840 dimerization interface [polypeptide binding]; other site 1305598005841 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1305598005842 DNA binding residues [nucleotide binding] 1305598005843 dimerization interface [polypeptide binding]; other site 1305598005844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1305598005845 Histidine kinase; Region: HisKA_3; pfam07730 1305598005846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598005847 ATP binding site [chemical binding]; other site 1305598005848 Mg2+ binding site [ion binding]; other site 1305598005849 G-X-G motif; other site 1305598005850 Predicted membrane protein [Function unknown]; Region: COG4758 1305598005851 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1305598005852 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1305598005853 active site 1305598005854 Predicted membrane protein [Function unknown]; Region: COG4129 1305598005855 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1305598005856 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1305598005857 catalytic triad [active] 1305598005858 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1305598005859 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1305598005860 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1305598005861 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1305598005862 Ferritin-like domain; Region: Ferritin; pfam00210 1305598005863 ferroxidase diiron center [ion binding]; other site 1305598005864 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1305598005865 active site 1305598005866 catalytic site [active] 1305598005867 substrate binding site [chemical binding]; other site 1305598005868 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1305598005869 active site 1305598005870 DNA polymerase IV; Validated; Region: PRK02406 1305598005871 DNA binding site [nucleotide binding] 1305598005872 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1305598005873 TRAM domain; Region: TRAM; cl01282 1305598005874 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1305598005875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598005876 S-adenosylmethionine binding site [chemical binding]; other site 1305598005877 putative lipid kinase; Reviewed; Region: PRK13337 1305598005878 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1305598005879 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1305598005880 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1305598005881 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1305598005882 GatB domain; Region: GatB_Yqey; pfam02637 1305598005883 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1305598005884 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1305598005885 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1305598005886 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1305598005887 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1305598005888 Na binding site [ion binding]; other site 1305598005889 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1305598005890 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1305598005891 putative dimer interface [polypeptide binding]; other site 1305598005892 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1305598005893 putative dimer interface [polypeptide binding]; other site 1305598005894 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1305598005895 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1305598005896 nucleotide binding pocket [chemical binding]; other site 1305598005897 K-X-D-G motif; other site 1305598005898 catalytic site [active] 1305598005899 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1305598005900 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1305598005901 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1305598005902 Dimer interface [polypeptide binding]; other site 1305598005903 Family description; Region: UvrD_C_2; pfam13538 1305598005904 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1305598005905 Part of AAA domain; Region: AAA_19; pfam13245 1305598005906 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1305598005907 PcrB family; Region: PcrB; pfam01884 1305598005908 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1305598005909 substrate binding site [chemical binding]; other site 1305598005910 putative active site [active] 1305598005911 dimer interface [polypeptide binding]; other site 1305598005912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1305598005913 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1305598005914 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1305598005915 tetramer interface [polypeptide binding]; other site 1305598005916 active site 1305598005917 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1305598005918 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1305598005919 Staphostatin A; Region: Staphostatin_A; pfam09022 1305598005920 NETI protein; Region: NETI; pfam14044 1305598005921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1305598005922 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1305598005923 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1305598005924 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1305598005925 homodimer interface [polypeptide binding]; other site 1305598005926 NAD binding pocket [chemical binding]; other site 1305598005927 ATP binding pocket [chemical binding]; other site 1305598005928 Mg binding site [ion binding]; other site 1305598005929 active-site loop [active] 1305598005930 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1305598005931 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1305598005932 active site 1305598005933 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1305598005934 active site 1305598005935 dimer interface [polypeptide binding]; other site 1305598005936 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1305598005937 Prephenate dehydratase; Region: PDT; pfam00800 1305598005938 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1305598005939 putative L-Phe binding site [chemical binding]; other site 1305598005940 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1305598005941 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1305598005942 transmembrane helices; other site 1305598005943 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1305598005944 Isochorismatase family; Region: Isochorismatase; pfam00857 1305598005945 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1305598005946 catalytic triad [active] 1305598005947 conserved cis-peptide bond; other site 1305598005948 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1305598005949 DHH family; Region: DHH; pfam01368 1305598005950 DHHA2 domain; Region: DHHA2; pfam02833 1305598005951 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1305598005952 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1305598005953 NAD(P) binding site [chemical binding]; other site 1305598005954 catalytic residues [active] 1305598005955 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1305598005956 YolD-like protein; Region: YolD; pfam08863 1305598005957 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1305598005958 active site 1305598005959 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1305598005960 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1305598005961 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1305598005962 Bacterial PH domain; Region: DUF304; cl01348 1305598005963 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 1305598005964 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1305598005965 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1305598005966 Walker A/P-loop; other site 1305598005967 ATP binding site [chemical binding]; other site 1305598005968 Q-loop/lid; other site 1305598005969 ABC transporter signature motif; other site 1305598005970 Walker B; other site 1305598005971 D-loop; other site 1305598005972 H-loop/switch region; other site 1305598005973 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1305598005974 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1305598005975 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1305598005976 Walker A/P-loop; other site 1305598005977 ATP binding site [chemical binding]; other site 1305598005978 Q-loop/lid; other site 1305598005979 ABC transporter signature motif; other site 1305598005980 Walker B; other site 1305598005981 D-loop; other site 1305598005982 H-loop/switch region; other site 1305598005983 Predicted transcriptional regulators [Transcription]; Region: COG1725 1305598005984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1305598005985 DNA-binding site [nucleotide binding]; DNA binding site 1305598005986 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1305598005987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1305598005988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598005989 homodimer interface [polypeptide binding]; other site 1305598005990 catalytic residue [active] 1305598005991 MAP domain; Region: MAP; pfam03642 1305598005992 MAP domain; Region: MAP; pfam03642 1305598005993 MAP domain; Region: MAP; pfam03642 1305598005994 MAP domain; Region: MAP; pfam03642 1305598005995 MAP domain; Region: MAP; pfam03642 1305598005996 MAP domain; Region: MAP; pfam03642 1305598005997 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1305598005998 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1305598005999 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1305598006000 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 1305598006001 CHAP domain; Region: CHAP; pfam05257 1305598006002 Small integral membrane protein [Function unknown]; Region: COG5546 1305598006003 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1305598006004 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598006005 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1305598006006 Ligand-gated ion channel; Region: Lig_chan; pfam00060 1305598006007 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 1305598006008 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1305598006009 TolA protein; Region: tolA_full; TIGR02794 1305598006010 Phage tail protein; Region: Sipho_tail; cl17486 1305598006011 Phage tail protein; Region: Sipho_tail; cl17486 1305598006012 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1305598006013 Phage-related protein [Function unknown]; Region: COG5412 1305598006014 Peptidase family M23; Region: Peptidase_M23; pfam01551 1305598006015 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1305598006016 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1305598006017 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1305598006018 catalytic residue [active] 1305598006019 AAA domain; Region: AAA_32; pfam13654 1305598006020 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1305598006021 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1305598006022 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1305598006023 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1305598006024 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1305598006025 oligomerization interface [polypeptide binding]; other site 1305598006026 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1305598006027 Phage capsid family; Region: Phage_capsid; pfam05065 1305598006028 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1305598006029 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1305598006030 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1305598006031 Phage Terminase; Region: Terminase_1; pfam03354 1305598006032 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1305598006033 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1305598006034 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1305598006035 active site 1305598006036 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1305598006037 putative metal binding site [ion binding]; other site 1305598006038 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1305598006039 Transcriptional activator RinB; Region: RinB; pfam06116 1305598006040 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 1305598006041 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1305598006042 dUTPase; Region: dUTPase_2; pfam08761 1305598006043 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1305598006044 active site 1305598006045 homodimer interface [polypeptide binding]; other site 1305598006046 metal binding site [ion binding]; metal-binding site 1305598006047 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1305598006048 YopX protein; Region: YopX; pfam09643 1305598006049 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1305598006050 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 1305598006051 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1305598006052 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 1305598006053 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1305598006054 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 1305598006055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598006056 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1305598006057 Walker A motif; other site 1305598006058 ATP binding site [chemical binding]; other site 1305598006059 Walker B motif; other site 1305598006060 arginine finger; other site 1305598006061 Helix-turn-helix domain; Region: HTH_36; pfam13730 1305598006062 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1305598006063 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1305598006064 AAA domain; Region: AAA_24; pfam13479 1305598006065 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 1305598006066 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1305598006067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 1305598006068 AntA/AntB antirepressor; Region: AntA; cl01430 1305598006069 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1305598006070 Protein of unknown function (DUF739); Region: DUF739; pfam05339 1305598006071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1305598006072 non-specific DNA binding site [nucleotide binding]; other site 1305598006073 salt bridge; other site 1305598006074 sequence-specific DNA binding site [nucleotide binding]; other site 1305598006075 Predicted transcriptional regulator [Transcription]; Region: COG2932 1305598006076 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1305598006077 Catalytic site [active] 1305598006078 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1305598006079 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1305598006080 Int/Topo IB signature motif; other site 1305598006081 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1305598006082 putative catalytic site [active] 1305598006083 phosphate binding site [ion binding]; other site 1305598006084 metal binding site A [ion binding]; metal-binding site 1305598006085 metal binding site C [ion binding]; metal-binding site 1305598006086 metal binding site B [ion binding]; metal-binding site 1305598006087 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1305598006088 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1305598006089 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1305598006090 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1305598006091 metal binding site [ion binding]; metal-binding site 1305598006092 dimer interface [polypeptide binding]; other site 1305598006093 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1305598006094 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1305598006095 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1305598006096 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1305598006097 putative ligand binding residues [chemical binding]; other site 1305598006098 Cation transport protein; Region: TrkH; cl17365 1305598006099 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1305598006100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598006101 Coenzyme A binding pocket [chemical binding]; other site 1305598006102 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1305598006103 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1305598006104 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1305598006105 ring oligomerisation interface [polypeptide binding]; other site 1305598006106 ATP/Mg binding site [chemical binding]; other site 1305598006107 stacking interactions; other site 1305598006108 hinge regions; other site 1305598006109 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1305598006110 oligomerisation interface [polypeptide binding]; other site 1305598006111 mobile loop; other site 1305598006112 roof hairpin; other site 1305598006113 CAAX protease self-immunity; Region: Abi; pfam02517 1305598006114 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1305598006115 dimer interface [polypeptide binding]; other site 1305598006116 FMN binding site [chemical binding]; other site 1305598006117 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1305598006118 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1305598006119 putative active site [active] 1305598006120 catalytic triad [active] 1305598006121 putative dimer interface [polypeptide binding]; other site 1305598006122 delta-hemolysin; Provisional; Region: PRK14752 1305598006123 Accessory gene regulator B; Region: AgrB; smart00793 1305598006124 Staphylococcal AgrD protein; Region: AgrD; smart00794 1305598006125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598006126 Mg2+ binding site [ion binding]; other site 1305598006127 G-X-G motif; other site 1305598006128 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1305598006129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598006130 active site 1305598006131 phosphorylation site [posttranslational modification] 1305598006132 intermolecular recognition site; other site 1305598006133 dimerization interface [polypeptide binding]; other site 1305598006134 LytTr DNA-binding domain; Region: LytTR; pfam04397 1305598006135 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1305598006136 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1305598006137 putative substrate binding site [chemical binding]; other site 1305598006138 putative ATP binding site [chemical binding]; other site 1305598006139 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1305598006140 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1305598006141 substrate binding [chemical binding]; other site 1305598006142 active site 1305598006143 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1305598006144 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1305598006145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1305598006146 DNA binding site [nucleotide binding] 1305598006147 domain linker motif; other site 1305598006148 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1305598006149 dimerization interface [polypeptide binding]; other site 1305598006150 ligand binding site [chemical binding]; other site 1305598006151 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1305598006152 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1305598006153 CPxP motif; other site 1305598006154 Predicted transporter component [General function prediction only]; Region: COG2391 1305598006155 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1305598006156 Sulphur transport; Region: Sulf_transp; pfam04143 1305598006157 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1305598006158 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1305598006159 CoA binding domain; Region: CoA_binding; pfam02629 1305598006160 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1305598006161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1305598006162 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1305598006163 ABC transporter; Region: ABC_tran_2; pfam12848 1305598006164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1305598006165 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 1305598006166 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 1305598006167 Walker A/P-loop; other site 1305598006168 ATP binding site [chemical binding]; other site 1305598006169 Q-loop/lid; other site 1305598006170 ABC transporter signature motif; other site 1305598006171 Walker B; other site 1305598006172 D-loop; other site 1305598006173 H-loop/switch region; other site 1305598006174 UGMP family protein; Validated; Region: PRK09604 1305598006175 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1305598006176 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1305598006177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598006178 Coenzyme A binding pocket [chemical binding]; other site 1305598006179 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1305598006180 Glycoprotease family; Region: Peptidase_M22; pfam00814 1305598006181 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1305598006182 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1305598006183 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1305598006184 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1305598006185 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1305598006186 PYR/PP interface [polypeptide binding]; other site 1305598006187 dimer interface [polypeptide binding]; other site 1305598006188 TPP binding site [chemical binding]; other site 1305598006189 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1305598006190 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1305598006191 TPP-binding site [chemical binding]; other site 1305598006192 dimer interface [polypeptide binding]; other site 1305598006193 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 1305598006194 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1305598006195 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1305598006196 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1305598006197 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1305598006198 2-isopropylmalate synthase; Validated; Region: PRK00915 1305598006199 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1305598006200 active site 1305598006201 catalytic residues [active] 1305598006202 metal binding site [ion binding]; metal-binding site 1305598006203 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1305598006204 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1305598006205 tartrate dehydrogenase; Region: TTC; TIGR02089 1305598006206 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1305598006207 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1305598006208 substrate binding site [chemical binding]; other site 1305598006209 ligand binding site [chemical binding]; other site 1305598006210 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1305598006211 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1305598006212 substrate binding site [chemical binding]; other site 1305598006213 threonine dehydratase; Validated; Region: PRK08639 1305598006214 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1305598006215 tetramer interface [polypeptide binding]; other site 1305598006216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598006217 catalytic residue [active] 1305598006218 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1305598006219 putative Ile/Val binding site [chemical binding]; other site 1305598006220 hypothetical protein; Provisional; Region: PRK04351 1305598006221 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1305598006222 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1305598006223 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1305598006224 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1305598006225 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1305598006226 RNA binding site [nucleotide binding]; other site 1305598006227 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1305598006228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1305598006229 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1305598006230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1305598006231 DNA binding residues [nucleotide binding] 1305598006232 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1305598006233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598006234 ATP binding site [chemical binding]; other site 1305598006235 Mg2+ binding site [ion binding]; other site 1305598006236 G-X-G motif; other site 1305598006237 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1305598006238 anti sigma factor interaction site; other site 1305598006239 regulatory phosphorylation site [posttranslational modification]; other site 1305598006240 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1305598006241 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1305598006242 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1305598006243 PemK-like protein; Region: PemK; pfam02452 1305598006244 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1305598006245 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1305598006246 active site 1305598006247 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1305598006248 dimer interface [polypeptide binding]; other site 1305598006249 substrate binding site [chemical binding]; other site 1305598006250 catalytic residues [active] 1305598006251 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1305598006252 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1305598006253 Predicted membrane protein [Function unknown]; Region: COG3428 1305598006254 Bacterial PH domain; Region: DUF304; pfam03703 1305598006255 Bacterial PH domain; Region: DUF304; pfam03703 1305598006256 Bacterial PH domain; Region: DUF304; cl01348 1305598006257 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 1305598006258 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 1305598006259 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1305598006260 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1305598006261 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1305598006262 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1305598006263 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1305598006264 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1305598006265 Ligand Binding Site [chemical binding]; other site 1305598006266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1305598006267 dimer interface [polypeptide binding]; other site 1305598006268 phosphorylation site [posttranslational modification] 1305598006269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598006270 ATP binding site [chemical binding]; other site 1305598006271 Mg2+ binding site [ion binding]; other site 1305598006272 G-X-G motif; other site 1305598006273 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1305598006274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598006275 active site 1305598006276 phosphorylation site [posttranslational modification] 1305598006277 intermolecular recognition site; other site 1305598006278 dimerization interface [polypeptide binding]; other site 1305598006279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1305598006280 DNA binding site [nucleotide binding] 1305598006281 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1305598006282 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1305598006283 ATP binding site [chemical binding]; other site 1305598006284 Mg++ binding site [ion binding]; other site 1305598006285 motif III; other site 1305598006286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1305598006287 nucleotide binding region [chemical binding]; other site 1305598006288 ATP-binding site [chemical binding]; other site 1305598006289 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1305598006290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1305598006291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1305598006292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1305598006293 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1305598006294 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1305598006295 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1305598006296 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1305598006297 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1305598006298 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1305598006299 putative homodimer interface [polypeptide binding]; other site 1305598006300 putative homotetramer interface [polypeptide binding]; other site 1305598006301 allosteric switch controlling residues; other site 1305598006302 putative metal binding site [ion binding]; other site 1305598006303 putative homodimer-homodimer interface [polypeptide binding]; other site 1305598006304 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1305598006305 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1305598006306 putative active site [active] 1305598006307 catalytic site [active] 1305598006308 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1305598006309 putative active site [active] 1305598006310 catalytic site [active] 1305598006311 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1305598006312 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1305598006313 Zn2+ binding site [ion binding]; other site 1305598006314 Mg2+ binding site [ion binding]; other site 1305598006315 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1305598006316 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1305598006317 thiamine phosphate binding site [chemical binding]; other site 1305598006318 active site 1305598006319 pyrophosphate binding site [ion binding]; other site 1305598006320 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1305598006321 substrate binding site [chemical binding]; other site 1305598006322 multimerization interface [polypeptide binding]; other site 1305598006323 ATP binding site [chemical binding]; other site 1305598006324 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1305598006325 dimer interface [polypeptide binding]; other site 1305598006326 substrate binding site [chemical binding]; other site 1305598006327 ATP binding site [chemical binding]; other site 1305598006328 thiaminase II; Region: salvage_TenA; TIGR04306 1305598006329 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1305598006330 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1305598006331 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1305598006332 dimer interface [polypeptide binding]; other site 1305598006333 ssDNA binding site [nucleotide binding]; other site 1305598006334 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1305598006335 YwpF-like protein; Region: YwpF; pfam14183 1305598006336 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1305598006337 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1305598006338 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1305598006339 hinge; other site 1305598006340 active site 1305598006341 Predicted membrane protein [Function unknown]; Region: COG4836 1305598006342 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 1305598006343 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1305598006344 gamma subunit interface [polypeptide binding]; other site 1305598006345 epsilon subunit interface [polypeptide binding]; other site 1305598006346 LBP interface [polypeptide binding]; other site 1305598006347 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1305598006348 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1305598006349 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1305598006350 alpha subunit interaction interface [polypeptide binding]; other site 1305598006351 Walker A motif; other site 1305598006352 ATP binding site [chemical binding]; other site 1305598006353 Walker B motif; other site 1305598006354 inhibitor binding site; inhibition site 1305598006355 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1305598006356 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1305598006357 core domain interface [polypeptide binding]; other site 1305598006358 delta subunit interface [polypeptide binding]; other site 1305598006359 epsilon subunit interface [polypeptide binding]; other site 1305598006360 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1305598006361 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1305598006362 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1305598006363 beta subunit interaction interface [polypeptide binding]; other site 1305598006364 Walker A motif; other site 1305598006365 ATP binding site [chemical binding]; other site 1305598006366 Walker B motif; other site 1305598006367 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1305598006368 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1305598006369 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1305598006370 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1305598006371 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1305598006372 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1305598006373 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1305598006374 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1305598006375 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1305598006376 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1305598006377 active site 1305598006378 homodimer interface [polypeptide binding]; other site 1305598006379 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1305598006380 active site 1305598006381 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1305598006382 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1305598006383 dimer interface [polypeptide binding]; other site 1305598006384 active site 1305598006385 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1305598006386 folate binding site [chemical binding]; other site 1305598006387 hypothetical protein; Provisional; Region: PRK13690 1305598006388 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1305598006389 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1305598006390 active site 1305598006391 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1305598006392 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1305598006393 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1305598006394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598006395 S-adenosylmethionine binding site [chemical binding]; other site 1305598006396 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1305598006397 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1305598006398 RF-1 domain; Region: RF-1; pfam00472 1305598006399 thymidine kinase; Provisional; Region: PRK04296 1305598006400 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1305598006401 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1305598006402 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1305598006403 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1305598006404 RNA binding site [nucleotide binding]; other site 1305598006405 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1305598006406 multimer interface [polypeptide binding]; other site 1305598006407 Walker A motif; other site 1305598006408 ATP binding site [chemical binding]; other site 1305598006409 Walker B motif; other site 1305598006410 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1305598006411 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1305598006412 NAD binding site [chemical binding]; other site 1305598006413 catalytic residues [active] 1305598006414 Predicted transcriptional regulators [Transcription]; Region: COG1733 1305598006415 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1305598006416 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1305598006417 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1305598006418 hinge; other site 1305598006419 active site 1305598006420 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1305598006421 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1305598006422 intersubunit interface [polypeptide binding]; other site 1305598006423 active site 1305598006424 zinc binding site [ion binding]; other site 1305598006425 Na+ binding site [ion binding]; other site 1305598006426 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1305598006427 CTP synthetase; Validated; Region: pyrG; PRK05380 1305598006428 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1305598006429 Catalytic site [active] 1305598006430 active site 1305598006431 UTP binding site [chemical binding]; other site 1305598006432 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1305598006433 active site 1305598006434 putative oxyanion hole; other site 1305598006435 catalytic triad [active] 1305598006436 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1305598006437 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1305598006438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598006439 Coenzyme A binding pocket [chemical binding]; other site 1305598006440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1305598006441 Coenzyme A binding pocket [chemical binding]; other site 1305598006442 pantothenate kinase; Provisional; Region: PRK13317 1305598006443 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1305598006444 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1305598006445 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1305598006446 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1305598006447 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1305598006448 metal binding site [ion binding]; metal-binding site 1305598006449 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1305598006450 Predicted membrane protein [Function unknown]; Region: COG4270 1305598006451 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1305598006452 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1305598006453 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1305598006454 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1305598006455 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1305598006456 intersubunit interface [polypeptide binding]; other site 1305598006457 active site 1305598006458 catalytic residue [active] 1305598006459 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1305598006460 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1305598006461 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1305598006462 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1305598006463 dimerization interface [polypeptide binding]; other site 1305598006464 DPS ferroxidase diiron center [ion binding]; other site 1305598006465 ion pore; other site 1305598006466 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1305598006467 EVE domain; Region: EVE; cl00728 1305598006468 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1305598006469 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1305598006470 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1305598006471 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1305598006472 NAD(P) binding site [chemical binding]; other site 1305598006473 putative active site [active] 1305598006474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1305598006475 dimerization interface [polypeptide binding]; other site 1305598006476 putative DNA binding site [nucleotide binding]; other site 1305598006477 putative Zn2+ binding site [ion binding]; other site 1305598006478 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1305598006479 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1305598006480 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1305598006481 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1305598006482 catalytic residues [active] 1305598006483 SAP domain; Region: SAP; pfam02037 1305598006484 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1305598006485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598006486 active site 1305598006487 motif I; other site 1305598006488 motif II; other site 1305598006489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598006490 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1305598006491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598006492 Walker A/P-loop; other site 1305598006493 ATP binding site [chemical binding]; other site 1305598006494 Q-loop/lid; other site 1305598006495 ABC transporter signature motif; other site 1305598006496 Walker B; other site 1305598006497 D-loop; other site 1305598006498 H-loop/switch region; other site 1305598006499 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1305598006500 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1305598006501 glutaminase active site [active] 1305598006502 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1305598006503 dimer interface [polypeptide binding]; other site 1305598006504 active site 1305598006505 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1305598006506 dimer interface [polypeptide binding]; other site 1305598006507 active site 1305598006508 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1305598006509 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1305598006510 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1305598006511 active site 1305598006512 P-loop; other site 1305598006513 phosphorylation site [posttranslational modification] 1305598006514 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1305598006515 HTH domain; Region: HTH_11; pfam08279 1305598006516 Mga helix-turn-helix domain; Region: Mga; pfam05043 1305598006517 PRD domain; Region: PRD; pfam00874 1305598006518 PRD domain; Region: PRD; pfam00874 1305598006519 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1305598006520 active site 1305598006521 P-loop; other site 1305598006522 phosphorylation site [posttranslational modification] 1305598006523 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1305598006524 active site 1305598006525 phosphorylation site [posttranslational modification] 1305598006526 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1305598006527 active site 1305598006528 phosphorylation site [posttranslational modification] 1305598006529 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1305598006530 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1305598006531 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1305598006532 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598006533 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1305598006534 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598006535 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598006536 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598006537 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598006538 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598006539 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1305598006540 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1305598006541 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1305598006542 active site 1305598006543 substrate binding site [chemical binding]; other site 1305598006544 metal binding site [ion binding]; metal-binding site 1305598006545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1305598006546 YbbR-like protein; Region: YbbR; pfam07949 1305598006547 TIGR00159 family protein; Region: TIGR00159 1305598006548 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1305598006549 Arginase family; Region: Arginase; cd09989 1305598006550 active site 1305598006551 Mn binding site [ion binding]; other site 1305598006552 oligomer interface [polypeptide binding]; other site 1305598006553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1305598006554 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1305598006555 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1305598006556 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1305598006557 Walker A motif; other site 1305598006558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598006559 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1305598006560 putative substrate translocation pore; other site 1305598006561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598006562 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1305598006563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598006564 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1305598006565 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1305598006566 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1305598006567 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1305598006568 substrate binding site; other site 1305598006569 dimerization interface; other site 1305598006570 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1305598006571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1305598006572 Nucleoside recognition; Region: Gate; pfam07670 1305598006573 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1305598006574 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598006575 ABC-ATPase subunit interface; other site 1305598006576 dimer interface [polypeptide binding]; other site 1305598006577 putative PBP binding regions; other site 1305598006578 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1305598006579 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1305598006580 ABC-ATPase subunit interface; other site 1305598006581 dimer interface [polypeptide binding]; other site 1305598006582 putative PBP binding regions; other site 1305598006583 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1305598006584 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1305598006585 siderophore binding site; other site 1305598006586 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1305598006587 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1305598006588 dimer interface [polypeptide binding]; other site 1305598006589 active site 1305598006590 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1305598006591 substrate binding site [chemical binding]; other site 1305598006592 catalytic residue [active] 1305598006593 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1305598006594 IucA / IucC family; Region: IucA_IucC; pfam04183 1305598006595 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1305598006596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598006597 putative substrate translocation pore; other site 1305598006598 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1305598006599 IucA / IucC family; Region: IucA_IucC; pfam04183 1305598006600 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1305598006601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598006602 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1305598006603 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1305598006604 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1305598006605 Asp23 family; Region: Asp23; pfam03780 1305598006606 Small integral membrane protein [Function unknown]; Region: COG5547 1305598006607 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1305598006608 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1305598006609 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1305598006610 putative NAD(P) binding site [chemical binding]; other site 1305598006611 dimer interface [polypeptide binding]; other site 1305598006612 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1305598006613 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1305598006614 NAD(P) binding site [chemical binding]; other site 1305598006615 substrate binding site [chemical binding]; other site 1305598006616 dimer interface [polypeptide binding]; other site 1305598006617 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1305598006618 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1305598006619 beta-galactosidase; Region: BGL; TIGR03356 1305598006620 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1305598006621 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1305598006622 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1305598006623 active site 1305598006624 P-loop; other site 1305598006625 phosphorylation site [posttranslational modification] 1305598006626 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1305598006627 methionine cluster; other site 1305598006628 active site 1305598006629 phosphorylation site [posttranslational modification] 1305598006630 metal binding site [ion binding]; metal-binding site 1305598006631 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1305598006632 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1305598006633 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1305598006634 putative substrate binding site [chemical binding]; other site 1305598006635 putative ATP binding site [chemical binding]; other site 1305598006636 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1305598006637 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1305598006638 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1305598006639 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1305598006640 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1305598006641 NAD-dependent deacetylase; Provisional; Region: PRK00481 1305598006642 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1305598006643 NAD+ binding site [chemical binding]; other site 1305598006644 substrate binding site [chemical binding]; other site 1305598006645 putative Zn binding site [ion binding]; other site 1305598006646 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1305598006647 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1305598006648 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1305598006649 active site 1305598006650 catalytic tetrad [active] 1305598006651 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1305598006652 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1305598006653 DNA binding residues [nucleotide binding] 1305598006654 putative dimer interface [polypeptide binding]; other site 1305598006655 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1305598006656 substrate binding site [chemical binding]; other site 1305598006657 catalytic residues [active] 1305598006658 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1305598006659 Peptidase family M23; Region: Peptidase_M23; pfam01551 1305598006660 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1305598006661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1305598006662 active site 1305598006663 motif I; other site 1305598006664 motif II; other site 1305598006665 MAP domain; Region: MAP; pfam03642 1305598006666 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1305598006667 acetolactate synthase; Reviewed; Region: PRK08617 1305598006668 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1305598006669 PYR/PP interface [polypeptide binding]; other site 1305598006670 dimer interface [polypeptide binding]; other site 1305598006671 TPP binding site [chemical binding]; other site 1305598006672 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1305598006673 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1305598006674 TPP-binding site [chemical binding]; other site 1305598006675 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1305598006676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598006677 Walker A motif; other site 1305598006678 ATP binding site [chemical binding]; other site 1305598006679 Walker B motif; other site 1305598006680 arginine finger; other site 1305598006681 Predicted helicase [General function prediction only]; Region: COG4889 1305598006682 Predicted helicase [General function prediction only]; Region: COG4889 1305598006683 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1305598006684 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1305598006685 23S rRNA interface [nucleotide binding]; other site 1305598006686 L3 interface [polypeptide binding]; other site 1305598006687 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1305598006688 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1305598006689 dimerization interface 3.5A [polypeptide binding]; other site 1305598006690 active site 1305598006691 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1305598006692 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1305598006693 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1305598006694 Walker A/P-loop; other site 1305598006695 ATP binding site [chemical binding]; other site 1305598006696 Q-loop/lid; other site 1305598006697 ABC transporter signature motif; other site 1305598006698 Walker B; other site 1305598006699 D-loop; other site 1305598006700 H-loop/switch region; other site 1305598006701 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1305598006702 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1305598006703 Walker A/P-loop; other site 1305598006704 ATP binding site [chemical binding]; other site 1305598006705 Q-loop/lid; other site 1305598006706 ABC transporter signature motif; other site 1305598006707 Walker B; other site 1305598006708 D-loop; other site 1305598006709 H-loop/switch region; other site 1305598006710 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1305598006711 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1305598006712 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1305598006713 alphaNTD homodimer interface [polypeptide binding]; other site 1305598006714 alphaNTD - beta interaction site [polypeptide binding]; other site 1305598006715 alphaNTD - beta' interaction site [polypeptide binding]; other site 1305598006716 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1305598006717 30S ribosomal protein S11; Validated; Region: PRK05309 1305598006718 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1305598006719 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1305598006720 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1305598006721 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1305598006722 rRNA binding site [nucleotide binding]; other site 1305598006723 predicted 30S ribosome binding site; other site 1305598006724 adenylate kinase; Reviewed; Region: adk; PRK00279 1305598006725 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1305598006726 AMP-binding site [chemical binding]; other site 1305598006727 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1305598006728 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1305598006729 SecY translocase; Region: SecY; pfam00344 1305598006730 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1305598006731 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1305598006732 23S rRNA binding site [nucleotide binding]; other site 1305598006733 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1305598006734 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1305598006735 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1305598006736 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1305598006737 5S rRNA interface [nucleotide binding]; other site 1305598006738 L27 interface [polypeptide binding]; other site 1305598006739 23S rRNA interface [nucleotide binding]; other site 1305598006740 L5 interface [polypeptide binding]; other site 1305598006741 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1305598006742 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1305598006743 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1305598006744 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1305598006745 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1305598006746 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1305598006747 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1305598006748 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1305598006749 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1305598006750 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1305598006751 RNA binding site [nucleotide binding]; other site 1305598006752 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1305598006753 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1305598006754 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1305598006755 23S rRNA interface [nucleotide binding]; other site 1305598006756 putative translocon interaction site; other site 1305598006757 signal recognition particle (SRP54) interaction site; other site 1305598006758 L23 interface [polypeptide binding]; other site 1305598006759 trigger factor interaction site; other site 1305598006760 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1305598006761 23S rRNA interface [nucleotide binding]; other site 1305598006762 5S rRNA interface [nucleotide binding]; other site 1305598006763 putative antibiotic binding site [chemical binding]; other site 1305598006764 L25 interface [polypeptide binding]; other site 1305598006765 L27 interface [polypeptide binding]; other site 1305598006766 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1305598006767 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1305598006768 G-X-X-G motif; other site 1305598006769 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1305598006770 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1305598006771 putative translocon binding site; other site 1305598006772 protein-rRNA interface [nucleotide binding]; other site 1305598006773 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1305598006774 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1305598006775 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1305598006776 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1305598006777 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1305598006778 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1305598006779 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1305598006780 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1305598006781 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1305598006782 DNA topoisomerase III; Provisional; Region: PRK07726 1305598006783 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1305598006784 active site 1305598006785 putative interdomain interaction site [polypeptide binding]; other site 1305598006786 putative metal-binding site [ion binding]; other site 1305598006787 putative nucleotide binding site [chemical binding]; other site 1305598006788 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1305598006789 domain I; other site 1305598006790 DNA binding groove [nucleotide binding] 1305598006791 phosphate binding site [ion binding]; other site 1305598006792 domain II; other site 1305598006793 domain III; other site 1305598006794 nucleotide binding site [chemical binding]; other site 1305598006795 catalytic site [active] 1305598006796 domain IV; other site 1305598006797 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1305598006798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598006799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1305598006800 Coenzyme A binding pocket [chemical binding]; other site 1305598006801 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1305598006802 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1305598006803 Predicted permeases [General function prediction only]; Region: COG0679 1305598006804 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1305598006805 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1305598006806 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1305598006807 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1305598006808 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1305598006809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598006810 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1305598006811 putative substrate translocation pore; other site 1305598006812 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598006813 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1305598006814 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1305598006815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1305598006816 FeS/SAM binding site; other site 1305598006817 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1305598006818 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1305598006819 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1305598006820 GTP binding site; other site 1305598006821 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1305598006822 MoaE interaction surface [polypeptide binding]; other site 1305598006823 MoeB interaction surface [polypeptide binding]; other site 1305598006824 thiocarboxylated glycine; other site 1305598006825 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1305598006826 MoaE homodimer interface [polypeptide binding]; other site 1305598006827 MoaD interaction [polypeptide binding]; other site 1305598006828 active site residues [active] 1305598006829 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 1305598006830 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1305598006831 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1305598006832 dimer interface [polypeptide binding]; other site 1305598006833 putative functional site; other site 1305598006834 putative MPT binding site; other site 1305598006835 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1305598006836 trimer interface [polypeptide binding]; other site 1305598006837 dimer interface [polypeptide binding]; other site 1305598006838 putative active site [active] 1305598006839 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1305598006840 MPT binding site; other site 1305598006841 trimer interface [polypeptide binding]; other site 1305598006842 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1305598006843 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1305598006844 ATP binding site [chemical binding]; other site 1305598006845 substrate interface [chemical binding]; other site 1305598006846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598006847 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1305598006848 Walker A/P-loop; other site 1305598006849 ATP binding site [chemical binding]; other site 1305598006850 Q-loop/lid; other site 1305598006851 ABC transporter signature motif; other site 1305598006852 Walker B; other site 1305598006853 D-loop; other site 1305598006854 H-loop/switch region; other site 1305598006855 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1305598006856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598006857 dimer interface [polypeptide binding]; other site 1305598006858 conserved gate region; other site 1305598006859 putative PBP binding loops; other site 1305598006860 ABC-ATPase subunit interface; other site 1305598006861 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1305598006862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1305598006863 substrate binding pocket [chemical binding]; other site 1305598006864 membrane-bound complex binding site; other site 1305598006865 hinge residues; other site 1305598006866 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1305598006867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598006868 Coenzyme A binding pocket [chemical binding]; other site 1305598006869 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1305598006870 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1305598006871 active site 1305598006872 dimerization interface [polypeptide binding]; other site 1305598006873 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1305598006874 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1305598006875 intersubunit interface [polypeptide binding]; other site 1305598006876 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1305598006877 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1305598006878 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1305598006879 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 1305598006880 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1305598006881 alpha-gamma subunit interface [polypeptide binding]; other site 1305598006882 beta-gamma subunit interface [polypeptide binding]; other site 1305598006883 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1305598006884 gamma-beta subunit interface [polypeptide binding]; other site 1305598006885 alpha-beta subunit interface [polypeptide binding]; other site 1305598006886 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1305598006887 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1305598006888 subunit interactions [polypeptide binding]; other site 1305598006889 active site 1305598006890 flap region; other site 1305598006891 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1305598006892 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1305598006893 dimer interface [polypeptide binding]; other site 1305598006894 catalytic residues [active] 1305598006895 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1305598006896 UreF; Region: UreF; pfam01730 1305598006897 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1305598006898 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1305598006899 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598006900 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598006901 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598006902 Helix-turn-helix domain; Region: HTH_18; pfam12833 1305598006903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1305598006904 Surface antigen [General function prediction only]; Region: COG3942 1305598006905 CHAP domain; Region: CHAP; pfam05257 1305598006906 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1305598006907 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1305598006908 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1305598006909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1305598006910 Surface antigen [General function prediction only]; Region: COG3942 1305598006911 CHAP domain; Region: CHAP; pfam05257 1305598006912 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1305598006913 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1305598006914 putative ligand binding site [chemical binding]; other site 1305598006915 putative NAD binding site [chemical binding]; other site 1305598006916 catalytic site [active] 1305598006917 hypothetical protein; Provisional; Region: PRK06753 1305598006918 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1305598006919 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1305598006920 Lysozyme subfamily 2; Region: LYZ2; smart00047 1305598006921 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1305598006922 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1305598006923 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1305598006924 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1305598006925 4Fe-4S binding domain; Region: Fer4; pfam00037 1305598006926 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1305598006927 [4Fe-4S] binding site [ion binding]; other site 1305598006928 molybdopterin cofactor binding site; other site 1305598006929 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1305598006930 molybdopterin cofactor binding site; other site 1305598006931 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1305598006932 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1305598006933 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1305598006934 active site 1305598006935 Predicted transcriptional regulator [Transcription]; Region: COG2378 1305598006936 HTH domain; Region: HTH_11; pfam08279 1305598006937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1305598006938 CAAX protease self-immunity; Region: Abi; pfam02517 1305598006939 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1305598006940 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1305598006941 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1305598006942 putative active site [active] 1305598006943 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1305598006944 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1305598006945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598006946 active site 1305598006947 motif I; other site 1305598006948 motif II; other site 1305598006949 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1305598006950 Sodium Bile acid symporter family; Region: SBF; pfam01758 1305598006951 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1305598006952 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1305598006953 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1305598006954 active site turn [active] 1305598006955 phosphorylation site [posttranslational modification] 1305598006956 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1305598006957 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1305598006958 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1305598006959 putative active site [active] 1305598006960 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1305598006961 putative hydrophobic ligand binding site [chemical binding]; other site 1305598006962 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1305598006963 oxidoreductase; Provisional; Region: PRK07985 1305598006964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1305598006965 NAD(P) binding site [chemical binding]; other site 1305598006966 active site 1305598006967 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1305598006968 amidohydrolase; Region: amidohydrolases; TIGR01891 1305598006969 metal binding site [ion binding]; metal-binding site 1305598006970 dimer interface [polypeptide binding]; other site 1305598006971 imidazolonepropionase; Validated; Region: PRK09356 1305598006972 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1305598006973 active site 1305598006974 urocanate hydratase; Provisional; Region: PRK05414 1305598006975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1305598006976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1305598006977 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1305598006978 dimerization interface [polypeptide binding]; other site 1305598006979 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1305598006980 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 1305598006981 putative active site [active] 1305598006982 putative Mg binding site [ion binding]; other site 1305598006983 formimidoylglutamase; Provisional; Region: PRK13775 1305598006984 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1305598006985 putative active site [active] 1305598006986 putative metal binding site [ion binding]; other site 1305598006987 CAAX protease self-immunity; Region: Abi; pfam02517 1305598006988 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1305598006989 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1305598006990 active site 1305598006991 dimer interface [polypeptide binding]; other site 1305598006992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1305598006993 MOSC domain; Region: MOSC; pfam03473 1305598006994 3-alpha domain; Region: 3-alpha; pfam03475 1305598006995 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1305598006996 active site 1305598006997 catalytic residues [active] 1305598006998 Uncharacterized conserved protein [Function unknown]; Region: COG1742 1305598006999 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1305598007000 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1305598007001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598007002 Walker A/P-loop; other site 1305598007003 ATP binding site [chemical binding]; other site 1305598007004 Q-loop/lid; other site 1305598007005 ABC transporter signature motif; other site 1305598007006 Walker B; other site 1305598007007 D-loop; other site 1305598007008 H-loop/switch region; other site 1305598007009 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1305598007010 Predicted membrane protein [Function unknown]; Region: COG3152 1305598007011 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1305598007012 active site 1305598007013 DNA binding site [nucleotide binding] 1305598007014 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1305598007015 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1305598007016 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1305598007017 homotetramer interface [polypeptide binding]; other site 1305598007018 FMN binding site [chemical binding]; other site 1305598007019 homodimer contacts [polypeptide binding]; other site 1305598007020 putative active site [active] 1305598007021 putative substrate binding site [chemical binding]; other site 1305598007022 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1305598007023 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1305598007024 oligomer interface [polypeptide binding]; other site 1305598007025 metal binding site [ion binding]; metal-binding site 1305598007026 metal binding site [ion binding]; metal-binding site 1305598007027 putative Cl binding site [ion binding]; other site 1305598007028 aspartate ring; other site 1305598007029 basic sphincter; other site 1305598007030 hydrophobic gate; other site 1305598007031 periplasmic entrance; other site 1305598007032 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1305598007033 active site 1305598007034 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1305598007035 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1305598007036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007037 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1305598007038 putative substrate translocation pore; other site 1305598007039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007040 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1305598007041 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1305598007042 HlyD family secretion protein; Region: HlyD_3; pfam13437 1305598007043 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1305598007044 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1305598007045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007046 putative substrate translocation pore; other site 1305598007047 Predicted membrane protein [Function unknown]; Region: COG4640 1305598007048 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1305598007049 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1305598007050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1305598007051 putative Zn2+ binding site [ion binding]; other site 1305598007052 putative DNA binding site [nucleotide binding]; other site 1305598007053 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1305598007054 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1305598007055 putative active site [active] 1305598007056 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1305598007057 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1305598007058 Walker A/P-loop; other site 1305598007059 ATP binding site [chemical binding]; other site 1305598007060 Q-loop/lid; other site 1305598007061 ABC transporter signature motif; other site 1305598007062 Walker B; other site 1305598007063 D-loop; other site 1305598007064 H-loop/switch region; other site 1305598007065 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1305598007066 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1305598007067 FtsX-like permease family; Region: FtsX; pfam02687 1305598007068 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1305598007069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598007070 active site 1305598007071 phosphorylation site [posttranslational modification] 1305598007072 intermolecular recognition site; other site 1305598007073 dimerization interface [polypeptide binding]; other site 1305598007074 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1305598007075 DNA binding site [nucleotide binding] 1305598007076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1305598007077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1305598007078 dimerization interface [polypeptide binding]; other site 1305598007079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1305598007080 dimer interface [polypeptide binding]; other site 1305598007081 phosphorylation site [posttranslational modification] 1305598007082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598007083 ATP binding site [chemical binding]; other site 1305598007084 Mg2+ binding site [ion binding]; other site 1305598007085 G-X-G motif; other site 1305598007086 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1305598007087 LytTr DNA-binding domain; Region: LytTR; smart00850 1305598007088 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1305598007089 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 1305598007090 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1305598007091 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1305598007092 L-lactate permease; Region: Lactate_perm; cl00701 1305598007093 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1305598007094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598007095 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1305598007096 Coenzyme A binding pocket [chemical binding]; other site 1305598007097 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1305598007098 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1305598007099 NAD(P) binding site [chemical binding]; other site 1305598007100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598007101 Coenzyme A binding pocket [chemical binding]; other site 1305598007102 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1305598007103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1305598007104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598007105 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1305598007106 Predicted membrane protein [Function unknown]; Region: COG1511 1305598007107 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1305598007108 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1305598007109 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1305598007110 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1305598007111 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1305598007112 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1305598007113 Cl binding site [ion binding]; other site 1305598007114 oligomer interface [polypeptide binding]; other site 1305598007115 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1305598007116 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1305598007117 active site turn [active] 1305598007118 phosphorylation site [posttranslational modification] 1305598007119 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1305598007120 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1305598007121 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1305598007122 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1305598007123 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1305598007124 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1305598007125 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1305598007126 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1305598007127 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1305598007128 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1305598007129 MarR family; Region: MarR_2; pfam12802 1305598007130 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1305598007131 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1305598007132 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1305598007133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007134 putative substrate translocation pore; other site 1305598007135 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1305598007136 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1305598007137 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1305598007138 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1305598007139 DNA binding residues [nucleotide binding] 1305598007140 dimer interface [polypeptide binding]; other site 1305598007141 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1305598007142 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1305598007143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598007144 active site 1305598007145 phosphorylation site [posttranslational modification] 1305598007146 intermolecular recognition site; other site 1305598007147 dimerization interface [polypeptide binding]; other site 1305598007148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1305598007149 DNA binding residues [nucleotide binding] 1305598007150 dimerization interface [polypeptide binding]; other site 1305598007151 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1305598007152 Histidine kinase; Region: HisKA_3; pfam07730 1305598007153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598007154 ATP binding site [chemical binding]; other site 1305598007155 Mg2+ binding site [ion binding]; other site 1305598007156 G-X-G motif; other site 1305598007157 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1305598007158 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1305598007159 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1305598007160 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1305598007161 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1305598007162 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1305598007163 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1305598007164 [4Fe-4S] binding site [ion binding]; other site 1305598007165 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1305598007166 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1305598007167 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1305598007168 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1305598007169 molybdopterin cofactor binding site; other site 1305598007170 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1305598007171 active site 1305598007172 SAM binding site [chemical binding]; other site 1305598007173 homodimer interface [polypeptide binding]; other site 1305598007174 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1305598007175 [2Fe-2S] cluster binding site [ion binding]; other site 1305598007176 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1305598007177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1305598007178 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1305598007179 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1305598007180 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1305598007181 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1305598007182 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1305598007183 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1305598007184 putative active site [active] 1305598007185 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1305598007186 active site 1305598007187 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1305598007188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598007189 Coenzyme A binding pocket [chemical binding]; other site 1305598007190 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1305598007191 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1305598007192 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1305598007193 putative hydrophobic ligand binding site [chemical binding]; other site 1305598007194 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1305598007195 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1305598007196 intersubunit interface [polypeptide binding]; other site 1305598007197 YodA lipocalin-like domain; Region: YodA; pfam09223 1305598007198 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1305598007199 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1305598007200 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1305598007201 Thioredoxin; Region: Thioredoxin_4; cl17273 1305598007202 FemAB family; Region: FemAB; pfam02388 1305598007203 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1305598007204 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1305598007205 Walker A/P-loop; other site 1305598007206 ATP binding site [chemical binding]; other site 1305598007207 Q-loop/lid; other site 1305598007208 ABC transporter signature motif; other site 1305598007209 Walker B; other site 1305598007210 D-loop; other site 1305598007211 H-loop/switch region; other site 1305598007212 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1305598007213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598007214 dimer interface [polypeptide binding]; other site 1305598007215 conserved gate region; other site 1305598007216 putative PBP binding loops; other site 1305598007217 ABC-ATPase subunit interface; other site 1305598007218 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1305598007219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1305598007220 substrate binding pocket [chemical binding]; other site 1305598007221 membrane-bound complex binding site; other site 1305598007222 hinge residues; other site 1305598007223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1305598007225 putative substrate translocation pore; other site 1305598007226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007227 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1305598007228 catalytic core [active] 1305598007229 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1305598007230 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1305598007231 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1305598007232 B domain; Region: B; pfam02216 1305598007233 B domain; Region: B; pfam02216 1305598007234 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 1305598007235 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1305598007236 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1305598007237 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1305598007238 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1305598007239 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1305598007240 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1305598007241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1305598007242 catalytic residue [active] 1305598007243 biotin synthase; Validated; Region: PRK06256 1305598007244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1305598007245 FeS/SAM binding site; other site 1305598007246 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1305598007247 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1305598007248 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1305598007249 inhibitor-cofactor binding pocket; inhibition site 1305598007250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598007251 catalytic residue [active] 1305598007252 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1305598007253 AAA domain; Region: AAA_26; pfam13500 1305598007254 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1305598007255 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1305598007256 Walker A/P-loop; other site 1305598007257 ATP binding site [chemical binding]; other site 1305598007258 Q-loop/lid; other site 1305598007259 ABC transporter signature motif; other site 1305598007260 Walker B; other site 1305598007261 D-loop; other site 1305598007262 H-loop/switch region; other site 1305598007263 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1305598007264 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1305598007265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598007266 Walker A/P-loop; other site 1305598007267 ATP binding site [chemical binding]; other site 1305598007268 Q-loop/lid; other site 1305598007269 ABC transporter signature motif; other site 1305598007270 Walker B; other site 1305598007271 D-loop; other site 1305598007272 H-loop/switch region; other site 1305598007273 Predicted membrane protein [Function unknown]; Region: COG2246 1305598007274 GtrA-like protein; Region: GtrA; pfam04138 1305598007275 glycerate kinase; Region: TIGR00045 1305598007276 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1305598007277 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1305598007278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007279 putative substrate translocation pore; other site 1305598007280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1305598007281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1305598007282 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1305598007283 putative phosphoesterase; Region: acc_ester; TIGR03729 1305598007284 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1305598007285 Spore germination protein; Region: Spore_permease; cl17796 1305598007286 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1305598007287 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1305598007288 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1305598007289 Beta-lactamase; Region: Beta-lactamase; pfam00144 1305598007290 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1305598007291 extended (e) SDRs; Region: SDR_e; cd08946 1305598007292 NAD(P) binding site [chemical binding]; other site 1305598007293 active site 1305598007294 substrate binding site [chemical binding]; other site 1305598007295 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1305598007296 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1305598007297 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1305598007298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007299 putative substrate translocation pore; other site 1305598007300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598007302 dimer interface [polypeptide binding]; other site 1305598007303 conserved gate region; other site 1305598007304 ABC-ATPase subunit interface; other site 1305598007305 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1305598007306 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1305598007307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598007308 dimer interface [polypeptide binding]; other site 1305598007309 conserved gate region; other site 1305598007310 putative PBP binding loops; other site 1305598007311 ABC-ATPase subunit interface; other site 1305598007312 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1305598007313 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1305598007314 Walker A/P-loop; other site 1305598007315 ATP binding site [chemical binding]; other site 1305598007316 Q-loop/lid; other site 1305598007317 ABC transporter signature motif; other site 1305598007318 Walker B; other site 1305598007319 D-loop; other site 1305598007320 H-loop/switch region; other site 1305598007321 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1305598007322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1305598007323 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1305598007324 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1305598007325 amino acid transporter; Region: 2A0306; TIGR00909 1305598007326 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1305598007327 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1305598007328 substrate binding pocket [chemical binding]; other site 1305598007329 catalytic triad [active] 1305598007330 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1305598007331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007332 putative substrate translocation pore; other site 1305598007333 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1305598007334 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1305598007335 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1305598007336 Walker A/P-loop; other site 1305598007337 ATP binding site [chemical binding]; other site 1305598007338 Q-loop/lid; other site 1305598007339 ABC transporter signature motif; other site 1305598007340 Walker B; other site 1305598007341 D-loop; other site 1305598007342 H-loop/switch region; other site 1305598007343 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1305598007344 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1305598007345 oligomer interface [polypeptide binding]; other site 1305598007346 active site 1305598007347 metal binding site [ion binding]; metal-binding site 1305598007348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 1305598007349 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1305598007350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1305598007351 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1305598007352 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1305598007353 active site 1305598007354 FMN binding site [chemical binding]; other site 1305598007355 substrate binding site [chemical binding]; other site 1305598007356 3Fe-4S cluster binding site [ion binding]; other site 1305598007357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1305598007359 putative substrate translocation pore; other site 1305598007360 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1305598007361 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1305598007362 Walker A/P-loop; other site 1305598007363 ATP binding site [chemical binding]; other site 1305598007364 Q-loop/lid; other site 1305598007365 ABC transporter signature motif; other site 1305598007366 Walker B; other site 1305598007367 D-loop; other site 1305598007368 H-loop/switch region; other site 1305598007369 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1305598007370 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1305598007371 Walker A/P-loop; other site 1305598007372 ATP binding site [chemical binding]; other site 1305598007373 Q-loop/lid; other site 1305598007374 ABC transporter signature motif; other site 1305598007375 Walker B; other site 1305598007376 D-loop; other site 1305598007377 H-loop/switch region; other site 1305598007378 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1305598007379 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1305598007380 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1305598007381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598007382 dimer interface [polypeptide binding]; other site 1305598007383 conserved gate region; other site 1305598007384 putative PBP binding loops; other site 1305598007385 ABC-ATPase subunit interface; other site 1305598007386 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1305598007387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1305598007388 dimer interface [polypeptide binding]; other site 1305598007389 conserved gate region; other site 1305598007390 putative PBP binding loops; other site 1305598007391 ABC-ATPase subunit interface; other site 1305598007392 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1305598007393 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1305598007394 substrate binding site [chemical binding]; other site 1305598007395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1305598007396 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1305598007397 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1305598007398 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1305598007399 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1305598007400 classical (c) SDRs; Region: SDR_c; cd05233 1305598007401 NAD(P) binding site [chemical binding]; other site 1305598007402 active site 1305598007403 AbgT putative transporter family; Region: ABG_transport; pfam03806 1305598007404 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1305598007405 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1305598007406 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1305598007407 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1305598007408 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1305598007409 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1305598007410 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1305598007411 classical (c) SDRs; Region: SDR_c; cd05233 1305598007412 NAD(P) binding site [chemical binding]; other site 1305598007413 active site 1305598007414 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1305598007415 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598007416 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598007417 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1305598007418 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1305598007419 PLD-like domain; Region: PLDc_2; pfam13091 1305598007420 putative homodimer interface [polypeptide binding]; other site 1305598007421 putative active site [active] 1305598007422 catalytic site [active] 1305598007423 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1305598007424 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1305598007425 ATP binding site [chemical binding]; other site 1305598007426 putative Mg++ binding site [ion binding]; other site 1305598007427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1305598007428 nucleotide binding region [chemical binding]; other site 1305598007429 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1305598007430 ATP-binding site [chemical binding]; other site 1305598007431 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1305598007432 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1305598007433 active site 1305598007434 8-oxo-dGMP binding site [chemical binding]; other site 1305598007435 nudix motif; other site 1305598007436 metal binding site [ion binding]; metal-binding site 1305598007437 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1305598007438 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1305598007439 active site 1305598007440 substrate binding site [chemical binding]; other site 1305598007441 metal binding site [ion binding]; metal-binding site 1305598007442 H+ Antiporter protein; Region: 2A0121; TIGR00900 1305598007443 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598007444 legume lectins; Region: lectin_L-type; cl14058 1305598007445 homotetramer interaction site [polypeptide binding]; other site 1305598007446 carbohydrate binding site [chemical binding]; other site 1305598007447 metal binding site [ion binding]; metal-binding site 1305598007448 G5 domain; Region: G5; pfam07501 1305598007449 G5 domain; Region: G5; pfam07501 1305598007450 G5 domain; Region: G5; pfam07501 1305598007451 G5 domain; Region: G5; pfam07501 1305598007452 G5 domain; Region: G5; pfam07501 1305598007453 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1305598007454 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598007455 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1305598007456 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598007457 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1305598007458 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1305598007459 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1305598007460 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1305598007461 active site 1305598007462 tetramer interface; other site 1305598007463 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1305598007464 Fibronectin binding repeat; Region: Fn_bind; pfam02986 1305598007465 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1305598007466 GntP family permease; Region: GntP_permease; pfam02447 1305598007467 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1305598007468 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1305598007469 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1305598007470 N- and C-terminal domain interface [polypeptide binding]; other site 1305598007471 active site 1305598007472 catalytic site [active] 1305598007473 metal binding site [ion binding]; metal-binding site 1305598007474 carbohydrate binding site [chemical binding]; other site 1305598007475 ATP binding site [chemical binding]; other site 1305598007476 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1305598007477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1305598007478 DNA-binding site [nucleotide binding]; DNA binding site 1305598007479 FCD domain; Region: FCD; pfam07729 1305598007480 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1305598007481 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1305598007482 DNA binding residues [nucleotide binding] 1305598007483 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1305598007484 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1305598007485 synthetase active site [active] 1305598007486 NTP binding site [chemical binding]; other site 1305598007487 metal binding site [ion binding]; metal-binding site 1305598007488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1305598007489 Predicted membrane protein [Function unknown]; Region: COG1289 1305598007490 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1305598007491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007492 D-galactonate transporter; Region: 2A0114; TIGR00893 1305598007493 putative substrate translocation pore; other site 1305598007494 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1305598007495 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1305598007496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1305598007497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1305598007498 putative substrate translocation pore; other site 1305598007499 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1305598007500 MarR family; Region: MarR; pfam01047 1305598007501 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1305598007502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598007503 Walker A/P-loop; other site 1305598007504 ATP binding site [chemical binding]; other site 1305598007505 Q-loop/lid; other site 1305598007506 ABC transporter signature motif; other site 1305598007507 Walker B; other site 1305598007508 D-loop; other site 1305598007509 H-loop/switch region; other site 1305598007510 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1305598007511 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1305598007512 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 1305598007513 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1305598007514 Predicted esterase [General function prediction only]; Region: COG0400 1305598007515 putative hydrolase; Provisional; Region: PRK11460 1305598007516 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1305598007517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1305598007518 Zn binding site [ion binding]; other site 1305598007519 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1305598007520 Zn binding site [ion binding]; other site 1305598007521 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1305598007522 MarR family; Region: MarR; pfam01047 1305598007523 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1305598007524 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1305598007525 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1305598007526 putative metal binding site [ion binding]; other site 1305598007527 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1305598007528 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1305598007529 dimer interface [polypeptide binding]; other site 1305598007530 FMN binding site [chemical binding]; other site 1305598007531 D-lactate dehydrogenase; Provisional; Region: PRK12480 1305598007532 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1305598007533 homodimer interface [polypeptide binding]; other site 1305598007534 ligand binding site [chemical binding]; other site 1305598007535 NAD binding site [chemical binding]; other site 1305598007536 catalytic site [active] 1305598007537 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1305598007538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1305598007539 active site 1305598007540 motif I; other site 1305598007541 motif II; other site 1305598007542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1305598007543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1305598007544 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1305598007545 Walker A/P-loop; other site 1305598007546 ATP binding site [chemical binding]; other site 1305598007547 Q-loop/lid; other site 1305598007548 ABC transporter signature motif; other site 1305598007549 Walker B; other site 1305598007550 D-loop; other site 1305598007551 H-loop/switch region; other site 1305598007552 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1305598007553 active site 1305598007554 catalytic site [active] 1305598007555 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1305598007556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598007557 Coenzyme A binding pocket [chemical binding]; other site 1305598007558 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1305598007559 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1305598007560 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1305598007561 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1305598007562 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1305598007563 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1305598007564 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1305598007565 EamA-like transporter family; Region: EamA; pfam00892 1305598007566 EamA-like transporter family; Region: EamA; pfam00892 1305598007567 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1305598007568 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1305598007569 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1305598007570 catalytic residues [active] 1305598007571 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1305598007572 active site 1305598007573 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1305598007574 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1305598007575 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1305598007576 active site turn [active] 1305598007577 phosphorylation site [posttranslational modification] 1305598007578 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1305598007579 HPr interaction site; other site 1305598007580 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1305598007581 active site 1305598007582 phosphorylation site [posttranslational modification] 1305598007583 pyruvate oxidase; Provisional; Region: PRK08611 1305598007584 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1305598007585 PYR/PP interface [polypeptide binding]; other site 1305598007586 tetramer interface [polypeptide binding]; other site 1305598007587 dimer interface [polypeptide binding]; other site 1305598007588 TPP binding site [chemical binding]; other site 1305598007589 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1305598007590 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1305598007591 TPP-binding site [chemical binding]; other site 1305598007592 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1305598007593 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1305598007594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1305598007595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1305598007596 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1305598007597 putative dimerization interface [polypeptide binding]; other site 1305598007598 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1305598007599 Surface antigen [General function prediction only]; Region: COG3942 1305598007600 CHAP domain; Region: CHAP; pfam05257 1305598007601 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1305598007602 homodimer interface [polypeptide binding]; other site 1305598007603 catalytic residues [active] 1305598007604 NAD binding site [chemical binding]; other site 1305598007605 substrate binding pocket [chemical binding]; other site 1305598007606 flexible flap; other site 1305598007607 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1305598007608 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1305598007609 dimer interface [polypeptide binding]; other site 1305598007610 active site 1305598007611 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1305598007612 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1305598007613 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1305598007614 DNA binding site [nucleotide binding] 1305598007615 active site 1305598007616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598007617 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1305598007618 Walker A motif; other site 1305598007619 ATP binding site [chemical binding]; other site 1305598007620 Walker B motif; other site 1305598007621 arginine finger; other site 1305598007622 UvrB/uvrC motif; Region: UVR; pfam02151 1305598007623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598007624 Walker A motif; other site 1305598007625 ATP binding site [chemical binding]; other site 1305598007626 Walker B motif; other site 1305598007627 arginine finger; other site 1305598007628 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1305598007629 Virus attachment protein p12 family; Region: P12; pfam12669 1305598007630 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1305598007631 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1305598007632 G1 box; other site 1305598007633 GTP/Mg2+ binding site [chemical binding]; other site 1305598007634 Switch I region; other site 1305598007635 G2 box; other site 1305598007636 G3 box; other site 1305598007637 Switch II region; other site 1305598007638 G4 box; other site 1305598007639 G5 box; other site 1305598007640 Nucleoside recognition; Region: Gate; pfam07670 1305598007641 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1305598007642 Nucleoside recognition; Region: Gate; pfam07670 1305598007643 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1305598007644 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1305598007645 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1305598007646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1305598007647 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1305598007648 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1305598007649 Glutamate binding site [chemical binding]; other site 1305598007650 homodimer interface [polypeptide binding]; other site 1305598007651 NAD binding site [chemical binding]; other site 1305598007652 catalytic residues [active] 1305598007653 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1305598007654 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1305598007655 active site 1305598007656 substrate binding site [chemical binding]; other site 1305598007657 trimer interface [polypeptide binding]; other site 1305598007658 CoA binding site [chemical binding]; other site 1305598007659 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1305598007660 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1305598007661 metal-binding site [ion binding] 1305598007662 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1305598007663 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1305598007664 metal-binding site [ion binding] 1305598007665 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1305598007666 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1305598007667 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1305598007668 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1305598007669 metal-binding site [ion binding] 1305598007670 D-lactate dehydrogenase; Validated; Region: PRK08605 1305598007671 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1305598007672 homodimer interface [polypeptide binding]; other site 1305598007673 ligand binding site [chemical binding]; other site 1305598007674 NAD binding site [chemical binding]; other site 1305598007675 catalytic site [active] 1305598007676 transaminase; Reviewed; Region: PRK08068 1305598007677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1305598007678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598007679 homodimer interface [polypeptide binding]; other site 1305598007680 catalytic residue [active] 1305598007681 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1305598007682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1305598007683 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1305598007684 active site lid residues [active] 1305598007685 substrate binding pocket [chemical binding]; other site 1305598007686 catalytic residues [active] 1305598007687 substrate-Mg2+ binding site; other site 1305598007688 aspartate-rich region 1; other site 1305598007689 aspartate-rich region 2; other site 1305598007690 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1305598007691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1305598007692 active site 1305598007693 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1305598007694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1305598007695 Surface antigen [General function prediction only]; Region: COG3942 1305598007696 CHAP domain; Region: CHAP; pfam05257 1305598007697 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1305598007698 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1305598007699 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1305598007700 catalytic triad [active] 1305598007701 catalytic triad [active] 1305598007702 oxyanion hole [active] 1305598007703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598007704 Coenzyme A binding pocket [chemical binding]; other site 1305598007705 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1305598007706 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1305598007707 catalytic residue [active] 1305598007708 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1305598007709 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1305598007710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1305598007711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1305598007712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1305598007713 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1305598007714 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1305598007715 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1305598007716 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1305598007717 NADP binding site [chemical binding]; other site 1305598007718 active site 1305598007719 regulatory binding site [polypeptide binding]; other site 1305598007720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 1305598007721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1305598007722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1305598007723 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 1305598007724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1305598007725 NAD(P) binding site [chemical binding]; other site 1305598007726 active site 1305598007727 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1305598007728 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1305598007729 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1305598007730 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1305598007731 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1305598007732 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1305598007733 Nucleoside recognition; Region: Gate; pfam07670 1305598007734 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1305598007735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1305598007736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 1305598007737 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1305598007738 Phosphotransferase enzyme family; Region: APH; pfam01636 1305598007739 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1305598007740 active site 1305598007741 ATP binding site [chemical binding]; other site 1305598007742 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1305598007743 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1305598007744 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1305598007745 quinone interaction residues [chemical binding]; other site 1305598007746 active site 1305598007747 catalytic residues [active] 1305598007748 FMN binding site [chemical binding]; other site 1305598007749 substrate binding site [chemical binding]; other site 1305598007750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1305598007751 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1305598007752 dimer interface [polypeptide binding]; other site 1305598007753 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1305598007754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1305598007755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1305598007756 Predicted acyl esterases [General function prediction only]; Region: COG2936 1305598007757 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1305598007758 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1305598007759 tetramerization interface [polypeptide binding]; other site 1305598007760 active site 1305598007761 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1305598007762 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1305598007763 active site 1305598007764 ATP-binding site [chemical binding]; other site 1305598007765 pantoate-binding site; other site 1305598007766 HXXH motif; other site 1305598007767 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1305598007768 oligomerization interface [polypeptide binding]; other site 1305598007769 active site 1305598007770 metal binding site [ion binding]; metal-binding site 1305598007771 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1305598007772 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1305598007773 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1305598007774 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1305598007775 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1305598007776 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1305598007777 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1305598007778 NAD binding site [chemical binding]; other site 1305598007779 dimer interface [polypeptide binding]; other site 1305598007780 substrate binding site [chemical binding]; other site 1305598007781 amino acid transporter; Region: 2A0306; TIGR00909 1305598007782 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1305598007783 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1305598007784 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1305598007785 inhibitor-cofactor binding pocket; inhibition site 1305598007786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598007787 catalytic residue [active] 1305598007788 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1305598007789 catalytic residue [active] 1305598007790 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1305598007791 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1305598007792 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1305598007793 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1305598007794 acyl-activating enzyme (AAE) consensus motif; other site 1305598007795 AMP binding site [chemical binding]; other site 1305598007796 active site 1305598007797 CoA binding site [chemical binding]; other site 1305598007798 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1305598007799 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1305598007800 choline dehydrogenase; Validated; Region: PRK02106 1305598007801 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1305598007802 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1305598007803 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1305598007804 tetramerization interface [polypeptide binding]; other site 1305598007805 NAD(P) binding site [chemical binding]; other site 1305598007806 catalytic residues [active] 1305598007807 Predicted transcriptional regulators [Transcription]; Region: COG1510 1305598007808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1305598007809 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1305598007810 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1305598007811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1305598007812 FeS/SAM binding site; other site 1305598007813 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1305598007814 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1305598007815 effector binding site; other site 1305598007816 active site 1305598007817 Zn binding site [ion binding]; other site 1305598007818 glycine loop; other site 1305598007819 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1305598007820 Citrate transporter; Region: CitMHS; pfam03600 1305598007821 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1305598007822 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1305598007823 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1305598007824 Flavodoxin; Region: Flavodoxin_1; pfam00258 1305598007825 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1305598007826 FAD binding pocket [chemical binding]; other site 1305598007827 FAD binding motif [chemical binding]; other site 1305598007828 catalytic residues [active] 1305598007829 NAD binding pocket [chemical binding]; other site 1305598007830 phosphate binding motif [ion binding]; other site 1305598007831 beta-alpha-beta structure motif; other site 1305598007832 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1305598007833 catalytic residues [active] 1305598007834 dimer interface [polypeptide binding]; other site 1305598007835 FtsX-like permease family; Region: FtsX; pfam02687 1305598007836 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1305598007837 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1305598007838 Walker A/P-loop; other site 1305598007839 ATP binding site [chemical binding]; other site 1305598007840 Q-loop/lid; other site 1305598007841 ABC transporter signature motif; other site 1305598007842 Walker B; other site 1305598007843 D-loop; other site 1305598007844 H-loop/switch region; other site 1305598007845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1305598007846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1305598007847 ATP binding site [chemical binding]; other site 1305598007848 Mg2+ binding site [ion binding]; other site 1305598007849 G-X-G motif; other site 1305598007850 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1305598007851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1305598007852 active site 1305598007853 phosphorylation site [posttranslational modification] 1305598007854 intermolecular recognition site; other site 1305598007855 dimerization interface [polypeptide binding]; other site 1305598007856 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1305598007857 DNA binding site [nucleotide binding] 1305598007858 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1305598007859 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1305598007860 dimer interface [polypeptide binding]; other site 1305598007861 active site 1305598007862 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1305598007863 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1305598007864 MarR family; Region: MarR_2; pfam12802 1305598007865 Predicted esterase [General function prediction only]; Region: COG0627 1305598007866 S-formylglutathione hydrolase; Region: PLN02442 1305598007867 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1305598007868 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1305598007869 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1305598007870 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1305598007871 ligand binding site [chemical binding]; other site 1305598007872 flexible hinge region; other site 1305598007873 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1305598007874 carbamate kinase; Reviewed; Region: PRK12686 1305598007875 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1305598007876 putative substrate binding site [chemical binding]; other site 1305598007877 nucleotide binding site [chemical binding]; other site 1305598007878 nucleotide binding site [chemical binding]; other site 1305598007879 homodimer interface [polypeptide binding]; other site 1305598007880 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1305598007881 ornithine carbamoyltransferase; Validated; Region: PRK02102 1305598007882 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1305598007883 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1305598007884 arginine deiminase; Provisional; Region: PRK01388 1305598007885 Arginine repressor [Transcription]; Region: ArgR; COG1438 1305598007886 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1305598007887 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1305598007888 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1305598007889 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1305598007890 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1305598007891 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1305598007892 active site 1305598007893 Zn binding site [ion binding]; other site 1305598007894 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1305598007895 HTH domain; Region: HTH_11; pfam08279 1305598007896 PRD domain; Region: PRD; pfam00874 1305598007897 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1305598007898 active site 1305598007899 P-loop; other site 1305598007900 phosphorylation site [posttranslational modification] 1305598007901 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1305598007902 active site 1305598007903 phosphorylation site [posttranslational modification] 1305598007904 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1305598007905 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1305598007906 active site 1305598007907 P-loop; other site 1305598007908 phosphorylation site [posttranslational modification] 1305598007909 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1305598007910 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1305598007911 active site 1305598007912 phosphorylation site [posttranslational modification] 1305598007913 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1305598007914 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1305598007915 Predicted membrane protein [Function unknown]; Region: COG1511 1305598007916 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1305598007917 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1305598007918 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1305598007919 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1305598007920 CHAP domain; Region: CHAP; pfam05257 1305598007921 Isochorismatase family; Region: Isochorismatase; pfam00857 1305598007922 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1305598007923 catalytic triad [active] 1305598007924 conserved cis-peptide bond; other site 1305598007925 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1305598007926 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1305598007927 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1305598007928 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1305598007929 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1305598007930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1305598007931 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1305598007932 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1305598007933 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1305598007934 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1305598007935 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1305598007936 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1305598007937 SecY translocase; Region: SecY; pfam00344 1305598007938 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1305598007939 legume lectins; Region: lectin_L-type; cd01951 1305598007940 homotetramer interaction site [polypeptide binding]; other site 1305598007941 carbohydrate binding site [chemical binding]; other site 1305598007942 metal binding site [ion binding]; metal-binding site 1305598007943 Putative Ig domain; Region: He_PIG; pfam05345 1305598007944 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1305598007945 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 1305598007946 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1305598007947 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1305598007948 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1305598007949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1305598007950 Coenzyme A binding pocket [chemical binding]; other site 1305598007951 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1305598007952 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1305598007953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1305598007954 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1305598007955 Chain length determinant protein; Region: Wzz; cl15801 1305598007956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1305598007957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1305598007958 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1305598007959 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1305598007960 DXD motif; other site 1305598007961 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 1305598007962 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 1305598007963 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1305598007964 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1305598007965 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1305598007966 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1305598007967 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1305598007968 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1305598007969 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1305598007970 metal binding site [ion binding]; metal-binding site 1305598007971 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1305598007972 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1305598007973 substrate binding site [chemical binding]; other site 1305598007974 glutamase interaction surface [polypeptide binding]; other site 1305598007975 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1305598007976 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1305598007977 catalytic residues [active] 1305598007978 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 1305598007979 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1305598007980 putative active site [active] 1305598007981 oxyanion strand; other site 1305598007982 catalytic triad [active] 1305598007983 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1305598007984 putative active site pocket [active] 1305598007985 4-fold oligomerization interface [polypeptide binding]; other site 1305598007986 metal binding residues [ion binding]; metal-binding site 1305598007987 3-fold/trimer interface [polypeptide binding]; other site 1305598007988 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1305598007989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1305598007990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1305598007991 homodimer interface [polypeptide binding]; other site 1305598007992 catalytic residue [active] 1305598007993 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1305598007994 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1305598007995 NAD binding site [chemical binding]; other site 1305598007996 dimerization interface [polypeptide binding]; other site 1305598007997 product binding site; other site 1305598007998 substrate binding site [chemical binding]; other site 1305598007999 zinc binding site [ion binding]; other site 1305598008000 catalytic residues [active] 1305598008001 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 1305598008002 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1305598008003 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 1305598008004 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1305598008005 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1305598008006 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1305598008007 putative active site [active] 1305598008008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1305598008009 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1305598008010 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1305598008011 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1305598008012 Walker A/P-loop; other site 1305598008013 ATP binding site [chemical binding]; other site 1305598008014 Q-loop/lid; other site 1305598008015 ABC transporter signature motif; other site 1305598008016 Walker B; other site 1305598008017 D-loop; other site 1305598008018 H-loop/switch region; other site 1305598008019 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1305598008020 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1305598008021 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1305598008022 Walker A/P-loop; other site 1305598008023 ATP binding site [chemical binding]; other site 1305598008024 Q-loop/lid; other site 1305598008025 ABC transporter signature motif; other site 1305598008026 Walker B; other site 1305598008027 D-loop; other site 1305598008028 H-loop/switch region; other site 1305598008029 hypothetical protein; Provisional; Region: PRK13661 1305598008030 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1305598008031 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1305598008032 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1305598008033 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1305598008034 Strictosidine synthase; Region: Str_synth; pfam03088 1305598008035 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1305598008036 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1305598008037 active site residue [active] 1305598008038 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1305598008039 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1305598008040 putative substrate binding pocket [chemical binding]; other site 1305598008041 AC domain interface; other site 1305598008042 catalytic triad [active] 1305598008043 AB domain interface; other site 1305598008044 interchain disulfide; other site 1305598008045 Transposase IS200 like; Region: Y1_Tnp; cl00848 1305598008046 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1305598008047 hypothetical protein; Validated; Region: PRK07668 1305598008048 Predicted transcriptional regulators [Transcription]; Region: COG1695 1305598008049 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1305598008050 DinB superfamily; Region: DinB_2; pfam12867 1305598008051 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1305598008052 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1305598008053 transmembrane helices; other site 1305598008054 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1305598008055 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1305598008056 hypothetical protein; Provisional; Region: PRK07758 1305598008057 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1305598008058 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1305598008059 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1305598008060 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1305598008061 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1305598008062 Walker A/P-loop; other site 1305598008063 ATP binding site [chemical binding]; other site 1305598008064 Q-loop/lid; other site 1305598008065 ABC transporter signature motif; other site 1305598008066 Walker B; other site 1305598008067 D-loop; other site 1305598008068 H-loop/switch region; other site 1305598008069 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1305598008070 FtsX-like permease family; Region: FtsX; pfam02687 1305598008071 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1305598008072 Integrase core domain; Region: rve; pfam00665 1305598008073 Integrase core domain; Region: rve_3; cl15866 1305598008074 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1305598008075 Integrase core domain; Region: rve_3; cl15866 1305598008076 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1305598008077 DNA-binding site [nucleotide binding]; DNA binding site 1305598008078 RNA-binding motif; other site 1305598008079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1305598008080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1305598008081 non-specific DNA binding site [nucleotide binding]; other site 1305598008082 salt bridge; other site 1305598008083 sequence-specific DNA binding site [nucleotide binding]; other site 1305598008084 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1305598008085 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1305598008086 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1305598008087 ParB-like nuclease domain; Region: ParBc; pfam02195 1305598008088 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1305598008089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1305598008090 S-adenosylmethionine binding site [chemical binding]; other site 1305598008091 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1305598008092 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1305598008093 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1305598008094 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1305598008095 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1305598008096 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1305598008097 G1 box; other site 1305598008098 GTP/Mg2+ binding site [chemical binding]; other site 1305598008099 Switch I region; other site 1305598008100 G2 box; other site 1305598008101 Switch II region; other site 1305598008102 G3 box; other site 1305598008103 G4 box; other site 1305598008104 G5 box; other site 1305598008105 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1305598008106 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1305598008107 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1305598008108 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1305598008109 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1305598008110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1305598008111 Walker A motif; other site 1305598008112 ATP binding site [chemical binding]; other site 1305598008113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1305598008114 Walker B motif; other site 1305598008115 arginine finger; other site 1305598008116 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1305598008117 DnaA box-binding interface [nucleotide binding]; other site 1305598008118 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1305598008119 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598008120 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1305598008121 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1305598008122 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1305598008123 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1305598008124 NADP binding site [chemical binding]; other site 1305598008125 dimer interface [polypeptide binding]; other site 1305598008126 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1305598008127 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1305598008128 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1305598008129 catalytic residues [active] 1305598008130 catalytic nucleophile [active] 1305598008131 Presynaptic Site I dimer interface [polypeptide binding]; other site 1305598008132 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1305598008133 Synaptic Flat tetramer interface [polypeptide binding]; other site 1305598008134 Synaptic Site I dimer interface [polypeptide binding]; other site 1305598008135 DNA binding site [nucleotide binding] 1305598008136 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1305598008137 DNA-binding interface [nucleotide binding]; DNA binding site 1305598008138 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1305598008139 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1305598008140 catalytic residues [active] 1305598008141 catalytic nucleophile [active] 1305598008142 Presynaptic Site I dimer interface [polypeptide binding]; other site 1305598008143 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1305598008144 Synaptic Flat tetramer interface [polypeptide binding]; other site 1305598008145 Synaptic Site I dimer interface [polypeptide binding]; other site 1305598008146 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1305598008147 DNA-binding interface [nucleotide binding]; DNA binding site 1305598008148 Predicted transcriptional regulator [Transcription]; Region: COG3682 1305598008149 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1305598008150 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1305598008151 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1305598008152 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1305598008153 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1305598008154 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1305598008155 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1305598008156 putative active site [active] 1305598008157 putative NTP binding site [chemical binding]; other site 1305598008158 putative nucleic acid binding site [nucleotide binding]; other site 1305598008159 Replication protein; Region: Rep_1; cl02412 1305598008160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1305598008161 putative DNA binding site [nucleotide binding]; other site 1305598008162 putative Zn2+ binding site [ion binding]; other site 1305598008163 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1305598008164 Cadmium resistance transporter; Region: Cad; pfam03596 1305598008165 Replication protein; Region: Rep_1; cl02412 1305598008166 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1305598008167 Replication protein; Region: Rep_1; pfam01446 1305598008168 Replication protein; Region: Rep_1; cl02412 1305598008169 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 1305598008170 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1305598008171 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876