-- dump date 20140620_074218 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_039478.1 49482254 2859597 517..1878 1 NC_002952.2 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1878 dnaA 2859597 dnaA Staphylococcus aureus subsp. aureus MRSA252 chromosomal replication initiation protein YP_039478.1 517 D 282458 CDS YP_039479.1 49482255 2859605 2156..3289 1 NC_002952.2 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3289 dnaN 2859605 dnaN Staphylococcus aureus subsp. aureus MRSA252 DNA polymerase III subunit beta YP_039479.1 2156 D 282458 CDS YP_039480.1 49482256 2859824 3670..3915 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YaaA SW:YAAA_BACSU (P05650) (71 aa) fasta scores: E(): 3.8e-07, 48.438% id in 64 aa, and to Bacillus halodurans hypothetical protein YyaA TR:Q9RCA0 (EMBL:AB013492) (73 aa) fasta scores: E(): 6.4e-07, 46.667% id in 60 aa; hypothetical protein 3915 2859824 SAR0003 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039480.1 3670 D 282458 CDS YP_039481.1 49482257 2859301 3912..5024 1 NC_002952.2 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 5024 recF 2859301 recF Staphylococcus aureus subsp. aureus MRSA252 recombination protein F YP_039481.1 3912 D 282458 CDS YP_039482.1 49482258 2859950 5037..6968 1 NC_002952.2 Previously sequenced as Staphylococcus aureus DNA gyrase subunit B GyrB SW:GYRB_STAAU (P20832) (643 aa) fasta scores: E(): 0, 99.844% id in 643 aa, Similar to Bacillus subtilis DNA gyrase subunit B GyrB SW:GYRB_BACSU (P05652) (638 aa) fasta scores: E(): 1.8e-166, 69.194% id in 633 aa. Similar to SAR0621, 23.973% identity (26.718% ungapped) in 146 aa overlap; DNA gyrase subunit B 6968 gyrB 2859950 gyrB Staphylococcus aureus subsp. aureus MRSA252 DNA gyrase subunit B YP_039482.1 5037 D 282458 CDS YP_039483.1 49482259 2859949 7005..9665 1 NC_002952.2 Previously sequenced as Staphylococcus aureus DNA gyrase subunit A GyrA SW:GYRA_STAAU (P20831) (889 aa) fasta scores: E(): 0, 98.875% id in 889 aa, Similar to and to Bacillus subtilis DNA gyrase subunit A GyrA SW:GYRA_BACSU (P05653) (821 aa) fasta scores: E(): 5e-194, 64.485% id in 825 aa; DNA gyrase subunit A 9665 gyrA 2859949 gyrA Staphylococcus aureus subsp. aureus MRSA252 DNA gyrase subunit A YP_039483.1 7005 D 282458 CDS YP_039484.1 49482260 2859825 complement(9753..10583) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YcfG TR:Q9CIU7 (EMBL:AE006263) (275 aa) fasta scores: E(): 5.6e-41, 47.445% id in 274 aa, and to Streptococcus thermophilus hypothetical protein YfoL SW:YFOL_STRTR (P96051) (278 aa) fasta scores: E(): 1.8e-40, 46.241% id in 266 aa; hypothetical protein 10583 2859825 SAR0007 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039484.1 9753 R 282458 CDS YP_039485.1 49482261 2859650 10891..12405 1 NC_002952.2 catalyzes the degradation of histidine to urocanate and ammmonia; histidine ammonia-lyase 12405 hutH 2859650 hutH Staphylococcus aureus subsp. aureus MRSA252 histidine ammonia-lyase YP_039485.1 10891 D 282458 CDS YP_039486.1 49482262 2859138 12783..14069 1 NC_002952.2 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 14069 serS 2859138 serS Staphylococcus aureus subsp. aureus MRSA252 seryl-tRNA synthetase YP_039486.1 12783 D 282458 CDS YP_039487.1 49482263 2859826 14713..15408 1 NC_002952.2 Similar to Bacillus subtilis probable branched-chain amino acid transport protein AzlC SW:AZLC_BACSU (O07942) (254 aa) fasta scores: E(): 3.5e-12, 28.182% id in 220 aa, and to Lactococcus lactis possible amino acid permease YqfD TR:Q9CF68 (EMBL:AE006391) (235 aa) fasta scores: E(): 1.6e-31, 40.773% id in 233 aa; hypothetical protein 15408 2859826 SAR0010 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039487.1 14713 D 282458 CDS YP_039488.1 49482264 2859827 15405..15734 1 NC_002952.2 Similar to Lactococcus lactis hypothteical protein YqfC TR:Q9CF69 (EMBL:AE006391) (108 aa) fasta scores: E(): 2.5e-09, 35.294% id in 102 aa, and to Leishmania major hypothetical protein LM12.1384 TR:Q9GVH4 (EMBL:AL390114) (109 aa) fasta scores: E(): 0.35, 26.804% id in 97 aa; hypothetical protein 15734 2859827 SAR0011 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039488.1 15405 D 282458 CDS YP_039489.1 49482265 2859828 16096..17064 1 NC_002952.2 Similar to Corynebacterium glutamicum homoserine O-acetyltransferase MetA SW:METX_CORGL (O68640) (379 aa) fasta scores: E(): 1.4e-05, 28.412% id in 359 aa, and to Thermus aquaticus homoserine O-acetyltransferase Met2 SW:METX_THETH (Q9RA51) (380 aa) fasta scores: E(): 2.7e-12, 34.783% id in 345 aa. Possible alternative translational start site; hydrolase 17064 2859828 SAR0012 Staphylococcus aureus subsp. aureus MRSA252 hydrolase YP_039489.1 16096 D 282458 CDS YP_039490.1 49482266 2859829 17309..18295 1 NC_002952.2 Weak similarity to Bacillus halodurans hypothetical protein BH4032 TR:Q9K5Q6 (EMBL:AP001520) (312 aa) fasta scores: E(): 9.9e-12, 22.295% id in 305 aa, and to Bacillus subtilis hypothetical protein YybS SW:YYBS_BACSU (P37485) (309 aa) fasta scores: E(): 5e-10, 22.006% id in 309 aa. Possible alternative translational start site; hypothetical protein 18295 2859829 SAR0013 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039490.1 17309 D 282458 CDS YP_039491.1 49482267 2859830 18310..20277 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YybT SW:YYBT_BACSU (P37484) (659 aa) fasta scores: E(): 1.4e-114, 50.779% id in 642 aa, and to Bacillus halodurans hypothetical protein BH4031 TR:Q9K5Q7 (EMBL:AP001520) (654 aa) fasta scores: E(): 1.6e-110, 45.912% id in 636 aa; hypothetical protein 20277 2859830 SAR0014 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039491.1 18310 D 282458 CDS YP_039492.1 49482268 2860904 20274..20720 1 NC_002952.2 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 20720 rplI 2860904 rplI Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L9 YP_039492.1 20274 D 282458 CDS YP_039493.1 49482269 2859599 20752..22152 1 NC_002952.2 Similar to Salmonella typhimurium replicative DNA helicase DnaB SW:DNAB_SALTY (P10338) (471 aa) fasta scores: E(): 1.8e-61, 44.812% id in 453 aa. Previously sequenced as Staphylococcus aureus helicase DnaC TR:Q9AQH7 (EMBL:AB054590) (466 aa) fasta scores: E(): 7.9e-176, 99.785% id in 466 aa; replicative DNA helicase 22152 dnaC 2859599 dnaC Staphylococcus aureus subsp. aureus MRSA252 replicative DNA helicase YP_039493.1 20752 D 282458 CDS YP_039494.1 49482270 2860158 22430..23713 1 NC_002952.2 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 23713 purA 2860158 purA Staphylococcus aureus subsp. aureus MRSA252 adenylosuccinate synthetase YP_039494.1 22430 D 282458 CDS YP_039495.1 49482271 2859628 24897..25604 1 NC_002952.2 Two-component regulatory system-family, response regulator protein. Previously sequenced as Staphylococcus aureus response regulator YycF TR:Q9XCM7 (EMBL:AF136709) (233 aa) fasta scores: E(): 1.5e-91, 100.000% id in 233 aa. Similar to Lactococcus lactis probable transcriptional regulatory protein ArcA TR:O86269 (EMBL:AJ001103) (233 aa) fasta scores: E(): 1.9e-57, 62.555% id in 227 aa. Similar to SAR1772, 52.155% identity (52.838% ungapped) in 232 aa overlap; response regulator protein 25604 yycF 2859628 yycF Staphylococcus aureus subsp. aureus MRSA252 response regulator protein YP_039495.1 24897 D 282458 CDS YP_039496.1 49482272 2859629 25617..27443 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Previously sequenced as Staphylococcus aureus two-component sensor histidine kinase YycG TR:Q9XCM6 (EMBL:AF136709) (608 aa) fasta scores: E(): 5.5e-214, 99.836% id in 608 aa. Similar to Bacillus subtilis probable two-component sensor histidine kinase YycG TR:Q45614 (EMBL:D78193) (611 aa) fasta scores: E(): 2e-98, 46.217% id in 608 aa; sensor kinase 27443 yycG 2859629 yycG Staphylococcus aureus subsp. aureus MRSA252 sensor kinase YP_039496.1 25617 D 282458 CDS YP_039497.1 49482273 2859630 27436..28770 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YycH TR:Q45613 (EMBL:D78193) (458 aa) fasta scores: E(): 2.7e-11, 19.697% id in 462 aa. Previously sequenced as Staphylococcus aureus hypothetical protein YycH TR:Q9RDT2 (EMBL:AJ012052) (465 aa) fasta scores: E(): 7.4e-166, 98.658% id in 447 aa. Possible alternative translational start site; hypothetical protein 28770 yycH 2859630 yycH Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039497.1 27436 D 282458 CDS YP_039498.1 49482274 2859631 28771..29559 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH4024 TR:Q9K5R4 (EMBL:AP001520) (262 aa) fasta scores: E(): 4.3e-11, 25.735% id in 272 aa. Previously sequenced as Staphylococcus aureus hypothetical protein YycI TR:Q9RDT1 (EMBL:AJ012052) (262 aa) fasta scores: E(): 4.1e-87, 97.710% id in 262 aa.; hypothetical protein 29559 yycI 2859631 yycI Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039498.1 28771 D 282458 CDS YP_039499.1 49482275 2859632 29947..30747 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YycJ TR:Q45611 (EMBL:D78193) (268 aa) fasta scores: E(): 3e-60, 62.069% id in 261 aa. Previously sequenced as Staphylococcus aureus hypothetical protein YycJ TR:Q9RDT0 (EMBL:AJ012052) (269 aa) fasta scores: E(): 2.4e-103, 99.624% id in 266 aa; metallo-beta-lactamase superfamily protein 30747 yycJ 2859632 yycJ Staphylococcus aureus subsp. aureus MRSA252 metallo-beta-lactamase superfamily protein YP_039499.1 29947 D 282458 CDS YP_039500.1 49482276 2859123 30932..33292 1 NC_002952.2 Internal region is similar to Discopyge ommata 5'-nucleotidase precursor protein SW:5NTD_DISOM (P29240) (577 aa) fasta scores: E(): 3.9e-19, 28.866% id in 582 aa, and to Rhizobium loti possible 5'-nucleotidase MLR3017 TR:BAB50004 (EMBL:AP003001) (706 aa) fasta scores: E(): 5.7e-22, 28.852% id in 610 aa. Probable LPXTG-sorted surface protein; 5'-nucleotidase 33292 sasH 2859123 sasH Staphylococcus aureus subsp. aureus MRSA252 5'-nucleotidase YP_039500.1 30932 D 282458 CDS YP_039501.1 49482277 2859831 33660..34139 1 NC_002952.2 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 34139 2859831 SAR0024 Staphylococcus aureus subsp. aureus MRSA252 rRNA large subunit methyltransferase YP_039501.1 33660 D 282458 CDS YP_039502.1 49482278 2859832 34422..35717 1 NC_002952.2 Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein TR:Q9KJC5 (EMBL:AF181950) (419 aa) fasta scores: E(): 2.6e-140, 99.752% id in 403 aa; hypothetical protein 35717 2859832 SAR0025 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039502.1 34422 D 282458 CDS YP_039503.1 49482279 2859833 36132..36371 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 36371 2859833 SAR0026 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039503.1 36132 D 282458 CDS YP_039504.1 49482280 2859834 complement(36403..37077) 1 NC_002952.2 Identical to Staphylococcus aureus IS431 transposase TR:BAB47631 (EMBL:AB037671) (224 aa) fasta scores: E(): 1.8e-88, 100.000% id in 224 aa, and similar to Staphylococcus epidermidis IS257 transposase Tnp TR:BAB39484 (EMBL:AB049452) (224 aa) fasta scores: E(): 1.4e-87, 99.107% id in 224 aa; transposase 37077 2859834 SAR0027 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_039504.1 36403 R 282458 CDS YP_039505.1 49482281 2859835 complement(38197..38373) 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 38373 2859835 SAR0030 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039505.1 38197 R 282458 CDS YP_039506.1 49482282 2860147 complement(38396..39658) 1 NC_002952.2 Identical to Staphylococcus aureus plasmid (pUB110) recombination enzyme Pre SW:PRE2_STAAU (P22490) (420 aa) fasta scores: E(): 3e-135, 100.000% id in 420 aa, and highly similar to Staphylococcus cohnii plasmid (pIP1714) recombination/mobilization protein Pre TR:O87277 (EMBL:AF015628) (420 aa) fasta scores: E(): 1.1e-134, 99.762% id in 420 aa. Contains coiled-coiled domain, residues 189 to 213; plasmid recombination enzyme 39658 pre 2860147 pre Staphylococcus aureus subsp. aureus MRSA252 plasmid recombination enzyme YP_039506.1 38396 R 282458 CDS YP_039507.1 49482283 2859836 39767..39907 1 NC_002952.2 Doubtful CDS. No significant database hits; hypothetical protein 39907 2859836 SAR0031a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039507.1 39767 D 282458 CDS YP_039508.1 49482284 2859837 39973..40146 1 NC_002952.2 Doubtful CDS. No significant database hits; hypothetical protein 40146 2859837 SAR0031b Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039508.1 39973 D 282458 CDS YP_039509.1 49482285 2859820 complement(40165..40569) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus bleomycin resistance protein Ble TR:BAA82230 (EMBL:D86934) (134 aa) fasta scores: E(): 3.6e-57, 99.254% id in 134 aa. Similar to Bacillus subtilis hypothetical protein YraH TR:O07918 (EMBL:X92868) (128 aa) fasta scores: E(): 0.0082, 26.357% id in 129 aa; bleomycin resistance protein 40569 ble 2859820 ble Staphylococcus aureus subsp. aureus MRSA252 bleomycin resistance protein YP_039509.1 40165 R 282458 CDS YP_039510.1 49482286 2859686 complement(40786..41556) 1 NC_002952.2 Highly similar to Staphylococcus aureus plasmid (pUB110) kanamycin nucleotidyltransferase Knt SW:KANU_STAAU (P05057) (253 aa) fasta scores: E(): 2.4e-104, 99.605% id in 253 aa, and to Bacillus sp plasmid (pRBH1 and pTB913) kanamycin nucleotidyltransferase Knt SW:KANU_BACSP (P05058) (253 aa) fasta scores: E(): 5.9e-104, 99.209% id in 253 aa; kanamycin nucleotidyltransferase 41556 knt 2859686 knt Staphylococcus aureus subsp. aureus MRSA252 kanamycin nucleotidyltransferase YP_039510.1 40786 R 282458 CDS YP_039511.1 49482287 2859838 complement(41749..42423) 1 NC_002952.2 Identical to Staphylococcus aureus IS431 transposase TR:BAB47631 (EMBL:AB037671) (224 aa) fasta scores: E(): 1.8e-88, 100.000% id in 224 aa, and similar to Staphylococcus epidermidis IS257 transposase Tnp TR:BAB39484 (EMBL:AB049452) (224 aa) fasta scores: E(): 1.4e-87, 99.107% id in 224 aa; transposase 42423 2859838 SAR0034 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_039511.1 41749 R 282458 CDS YP_039512.1 49482288 2859840 42946..43155 1 NC_002952.2 Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein TR:Q9XB76 (EMBL:D86934) (76 aa) fasta scores: E(): 2.7e-26, 100.000% id in 69 aa. CDS is 7 amino acids shorter at the C-terminus; hypothetical protein 43155 2859840 SAR0036 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039512.1 42946 D 282458 CDS YP_039513.1 49482289 2860411 43605..44348 1 NC_002952.2 Similar to Escherichia coli glycerophosphoryl diester phosphodiesterase UgpQ SW:UGPQ_ECOLI (P10908) (247 aa) fasta scores: E(): 1.6e-22, 35.443% id in 237 aa. Previously sequenced as Staphylococcus aureus glycerophosphoryldiester phosphodiesterase UgpQ TR:Q9S3K5 (EMBL:D86934) (247 aa) fasta scores: E(): 2e-93, 100.000% id in 247 aa; glycerophosphoryl diester phosphodiesterase 44348 ugpQ 2860411 ugpQ Staphylococcus aureus subsp. aureus MRSA252 glycerophosphoryl diester phosphodiesterase YP_039513.1 43605 D 282458 CDS YP_039514.1 49482290 2859841 44445..44873 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47625 (EMBL:AB037671) (142 aa) fasta scores: E(): 2e-52, 100.000% id in 142 aa. Similar to Bacillus subtilis YdeM protein ydeM TR:P96670 (EMBL:AB001488) (141 aa) fasta scores: E(): 1.5e-30, 56.115% id in 139 aa; hypothetical protein 44873 2859841 SAR0038 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039514.1 44445 D 282458 CDS YP_039515.1 49482291 2861157 complement(44919..46925) 1 NC_002952.2 Identical to Staphylococcus epidermidis, and Staphylococcus aureus penicillin-binding protein 2 prime MecA TR:Q54113 (EMBL:X52592) (668 aa) fasta scores: E(): 0, 100.000% id in 668 aa, and to Staphylococcus sciuri methicillin resistanc protein MecA2 TR:O54283 (EMBL:Y13095) (668 aa) fasta scores: E(): 0, 99.102% id in 668 aa; penicillin-binding protein 2 prime 46925 mecA 2861157 mecA Staphylococcus aureus subsp. aureus MRSA252 penicillin-binding protein 2 prime YP_039515.1 44919 R 282458 CDS YP_039516.1 49482292 2861159 47025..48782 1 NC_002952.2 Highly similar to Staphylococcus epidermidis, and Staphylococcus aureus methicillin resistance protein MecR1 SW:MECR_STAEP (P26597) (585 aa) fasta scores: E(): 0, 99.829% id in 585 aa, and to Staphylococcus sciuri methicillin resistance protein MecR1 TR:CAA73546 (EMBL:Y13096) (585 aa) fasta scores: E(): 0, 99.829% id in 585 aa; methicillin resistance protein MecR1 48782 mecR1 2861159 mecR1 Staphylococcus aureus subsp. aureus MRSA252 methicillin resistance protein MecR1 YP_039516.1 47025 D 282458 CDS YP_039517.1 49482293 2861158 48782..49126 1 NC_002952.2 Previously sequenced as Staphylococcus epidermidis, and Staphylococcus aureus methicillin resistance regulatory protein MecI SW:MECI_STAEP (P26598) (123 aa) fasta scores: E(): 2.5e-41, 100.000% id in 114 aa. Similar to and to Staphylococcus haemolyticus beta-lactamase repressor BlaI TR:Q9K4N1 (EMBL:AJ400722) (126 aa) fasta scores: E(): 9e-20, 59.649% id in 114 aa. Similar to SAR1829, 59.649% identity (59.649% ungapped) in 114 aa overlap; methicillin resistance regulatory protein MecI 49126 mecI 2861158 mecI Staphylococcus aureus subsp. aureus MRSA252 methicillin resistance regulatory protein MecI YP_039517.1 48782 D 282458 CDS YP_039518.1 49482294 2859842 49263..49466 1 NC_002952.2 Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47620 (EMBL:AB037671) (70 aa) fasta scores: E(): 6.3e-26, 100.000% id in 67 aa; hypothetical protein 49466 2859842 SAR0042 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039518.1 49263 D 282458 CDS YP_039519.1 49482295 2859844 complement(52251..53315) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47615 (EMBL:AB037671) (354 aa) fasta scores: E(): 3.9e-133, 100.000% id in 354 aa. C-terminus is similar to Bacillus subtilis hypothetical protein YrkE SW:YRKE_BACSU (P54432) (160 aa) fasta scores: E(): 7.3e-25, 52.941% id in 153 aa; hypothetical protein 53315 2859844 SAR0046 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039519.1 52251 R 282458 CDS YP_039520.1 49482296 2859845 53445..53711 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47614 (EMBL:AB037671) (88 aa) fasta scores: E(): 2.8e-29, 100.000% id in 88 aa. Similar to Lactococcus lactis hypothetical protein YhjE TR:Q9CHE5 (EMBL:AE006312) (84 aa) fasta scores: E(): 3.2e-09, 42.683% id in 82 aa; hypothetical protein 53711 2859845 SAR0047 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039520.1 53445 D 282458 CDS YP_039521.1 49482297 2860468 complement(54694..55356) 1 NC_002952.2 Highly similar to Staphylococcus aureus transposon Tn554 hypothetical protein TR:Q48363 (EMBL:X03216) (220 aa) fasta scores: E(): 2.8e-82, 99.545% id in 220 aa, and to Lactococcus lactis hypothetical protein YljG TR:Q9CGB7 (EMBL:AE006350) (206 aa) fasta scores: E(): 3.2e-06, 25.837% id in 209 aa; hypothetical protein 55356 2860468 SAR0049 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039521.1 54694 R 282458 CDS YP_039522.1 49482298 2859614 55890..56621 1 NC_002952.2 Previously sequenced as Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance protein, rRNA adenine N-6-methyltransferase ErmA SW:ERM1_STAAU (P06699) (243 aa) fasta scores: E(): 1.7e-90, 100.000% id in 243 aa. Similar to Streptococcus pyogenes erythromycin resistance methylase ErmTR TR:O07480 (EMBL:AF002716) (243 aa) fasta scores: E(): 7.2e-74, 81.070% id in 243 aa; rRNA adenine N-6-methyltransferase 1 56621 ermA1 2859614 ermA1 Staphylococcus aureus subsp. aureus MRSA252 rRNA adenine N-6-methyltransferase 1 YP_039522.1 55890 D 282458 CDS YP_039523.1 49482299 2859153 complement(56747..57529) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus streptomycin and spectomycin resistance protein, streptomycin 3''-adenylyltransferase Spc SW:S3AD_STAAU (P04827) (260 aa) fasta scores: E(): 4e-100, 100.000% id in 260 aa. Similar to Streptomyces coelicolor nucleotidyltransferase SCD19.10 TR:Q9F2Z2 (EMBL:AL392149) (257 aa) fasta scores: E(): 4.6e-34, 44.493% id in 227 aa; streptomycin 3''-adenylyltransferase 1 57529 spc1 2859153 spc1 Staphylococcus aureus subsp. aureus MRSA252 streptomycin 3''-adenylyltransferase 1 YP_039523.1 56747 R 282458 CDS YP_039524.1 49482300 2859541 complement(57680..58057) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus transposase C TnpC TR:BAB47665 (EMBL:AB037671) (125 aa) fasta scores: E(): 1.1e-36, 100.000% id in 125 aa. Similar to Clostridium butyricum similar hypothetical protein TR:Q45924 (EMBL:Z29084) (124 aa) fasta scores: E(): 2.1e-09, 41.818% id in 110 aa; transposase C 1 58057 tnpC1 2859541 tnpC1 Staphylococcus aureus subsp. aureus MRSA252 transposase C 1 YP_039524.1 57680 R 282458 CDS YP_039525.1 49482301 2859539 complement(58064..59956) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus transposon Tn554 transposase B TnpB SW:TNPB_STAAU (P06697) (630 aa) fasta scores: E(): 0, 100.000% id in 630 aa. Similar to Clostridium butyricum hypothetical protein TR:Q45923 (EMBL:Z29084) (660 aa) fasta scores: E(): 1.7e-14, 24.734% id in 659 aa; transposase B 1 59956 tnpB1 2859539 tnpB1 Staphylococcus aureus subsp. aureus MRSA252 transposase B 1 YP_039525.1 58064 R 282458 CDS YP_039526.1 49482302 2859537 complement(59953..61038) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus transposon Tn554 transposase A TnpA SW:TNPA_STAAU (P06696) (361 aa) fasta scores: E(): 6.8e-137, 99.723% id in 361 aa. Similar to Clostridium butyricum hypothetical protein TR:Q45922 (EMBL:Z29084) (364 aa) fasta scores: E(): 2.6e-28, 37.752% id in 347 aa; transposase A 1 61038 tnpA1 2859537 tnpA1 Staphylococcus aureus subsp. aureus MRSA252 transposase A 1 YP_039526.1 59953 R 282458 CDS YP_039527.1 49482303 2860470 complement(61495..62001) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical protein Orf N043 TR:Q9KX75 (EMBL:D86934) (168 aa) fasta scores: E(): 2.5e-62, 100.000% id in 168 aa. Similar to Escherichia coli O157:H7 hypothetical protein ECS5248 TR:BAB38671 (EMBL:AP002569) (155 aa) fasta scores: E(): 7e-07, 31.333% id in 150 aa; hypothetical protein 62001 2860470 SAR0056 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039527.1 61495 R 282458 CDS YP_039528.1 49482304 2860471 complement(62019..62330) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical protein Orf N042 TR:Q9KX76 (EMBL:D86934) (103 aa) fasta scores: E(): 3.4e-41, 100.000% id in 103 aa; hypothetical protein 62330 2860471 SAR0057 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039528.1 62019 R 282458 CDS YP_039529.1 49482305 2860472 complement(62417..62767) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical protein Orf N041 TR:Q9KX77 (EMBL:D86934) (116 aa) fasta scores: E(): 2.5e-47, 100.000% id in 116 aa; hypothetical protein 62767 2860472 SAR0058 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039529.1 62417 R 282458 CDS YP_039530.1 49482306 2861354 complement(63285..64913) 1 NC_002952.2 Similar to Staphylococcus aureus site-specific recombinase CcrB TR:Q9XB94 (EMBL:D86934) (542 aa) fasta scores: E(): 5.6e-194, 99.815% id in 542 aa, and to lactococcal bacteriophage TP901-1 integrase Int TR:Q38184 (EMBL:X85213) (485 aa) fasta scores: E(): 2.6e-24, 28.880% id in 509 aa; site-specific recombinase 64913 ccrB 2861354 ccrB Staphylococcus aureus subsp. aureus MRSA252 site-specific recombinase YP_039530.1 63285 R 282458 CDS YP_039531.1 49482307 2861353 complement(64935..66284) 1 NC_002952.2 Similar to Staphylococcus aureus, and site-specific recombinase CcrA TR:Q9XB96 (EMBL:D86934) (449 aa) fasta scores: E(): 4.4e-165, 95.323% id in 449 aa, and to Enterococcus faecalis bacteriophage phi-FC1 site-specific integrase TR:Q9XJF6 (EMBL:AF124258) (464 aa) fasta scores: E(): 8.9e-18, 26.154% id in 455 aa; site-specific recombinase 66284 ccrA 2861353 ccrA Staphylococcus aureus subsp. aureus MRSA252 site-specific recombinase YP_039531.1 64935 R 282458 CDS YP_039532.1 49482308 2860473 complement(66518..68311) 1 NC_002952.2 Similar to Staphylococcus aureus hypothetical protein Orf N031TR:Q9KX82 (EMBL:D86934) (597 aa) fasta scores: E(): 0, 97.822% id in 597 aa. N-terminus is similar to SAR0075, 60.068% identity (60.690% ungapped) in 293 aa overlap and C-terminus is similar to SAR0074, 50.530% identity (51.254% ungapped) in 283 aa overlap; hypothetical protein 68311 2860473 SAR0061 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039532.1 66518 R 282458 CDS YP_039533.1 49482309 2860474 complement(68311..68607) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical protein Orf N030 TR:Q9KX83 (EMBL:D86934) (98 aa) fasta scores: E(): 3e-41, 100.000% id in 98 aa; hypothetical protein 68607 2860474 SAR0062 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039533.1 68311 R 282458 CDS YP_039534.1 49482310 2860475 complement(68800..69846) 1 NC_002952.2 Poor database matches. Similar to an internal region of Plasmodium falciparum exported serine/threonine protein kinase FesT TR:Q94658 (EMBL:U40232) (2510 aa) fasta scores: E(): 0.021, 23.416% id in 363 aa. Previously sequenced as Staphylococcus aureus hypothetical protein Orf N029 TR:Q9KX84 (EMBL:D86934) (348 aa) fasta scores: E(): 2.5e-118, 100.000% id in 348 aa; hypothetical protein 69846 2860475 SAR0063 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039534.1 68800 R 282458 CDS YP_039535.1 49482311 2860477 complement(70924..71238) 1 NC_002952.2 Similar to Bacillus anthracis similar IS1627s1 element OrfA TR:Q57266 (EMBL:U30714) (106 aa) fasta scores: E(): 3.2e-18, 51.456% id in 103 aa, and to Marinococcus halophilus transposase TR:O06062 (EMBL:U66614) (110 aa) fasta scores: E(): 9.3e-13, 42.000% id in 100 aa; transposase 71238 2860477 SAR0066 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_039535.1 70924 R 282458 CDS YP_039536.1 49482312 2859684 complement(73397..74092) 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Similar to Escherichia coli kdp operon transcriptional regulatory protein KdpE SW:KDPE_ECOLI (P21866) (225 aa) fasta scores: E(): 2.7e-28, 41.593% id in 226 aa. Previously sequenced as Staphylococcus aureus kdp operon transcriptional regulatory protein KdpE TR:Q9XBA2 (EMBL:D86934) (231 aa) fasta scores: E(): 5.5e-88, 100.000% id in 231 aa. Similar to SAR2167, 61.233% identity (61.778% ungapped) in 227 aa overlap; response regulator protein 74092 kdpE 2859684 kdpE Staphylococcus aureus subsp. aureus MRSA252 response regulator protein YP_039536.1 73397 R 282458 CDS YP_039537.1 49482313 2860479 complement(74067..76787) 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Similar to Clostridium acetobutylicum histidine kinase sensor protein KdpD SW:KDPD_CLOAB (P94608) (900 aa) fasta scores: E(): 1.2e-75, 29.538% id in 887 aa, and to Rhizobium loti two-component sensor KdpD TR:BAB50088 (EMBL:AP003001) (907 aa) fasta scores: E(): 3.5e-70, 28.699% id in 899 aa. Similar to SAR2166, 58.142% identity (58.613% ungapped) in 872 aa overlap; sensor kinase 76787 2860479 SAR0069 Staphylococcus aureus subsp. aureus MRSA252 sensor kinase YP_039537.1 74067 R 282458 CDS YP_039538.1 49482314 2860480 77004..78680 1 NC_002952.2 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 78680 2860480 SAR0070 Staphylococcus aureus subsp. aureus MRSA252 potassium-transporting ATPase subunit A YP_039538.1 77004 D 282458 CDS YP_039539.1 49482315 2860481 78699..80720 1 NC_002952.2 one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 80720 2860481 SAR0071 Staphylococcus aureus subsp. aureus MRSA252 potassium-transporting ATPase subunit B YP_039539.1 78699 D 282458 CDS YP_039540.1 49482316 2860483 complement(81837..82706) 1 NC_002952.2 Poor database matches. Similar to the C-terminal region of Staphylococcus aureus hypothetical protein Orf N031 TR:Q9KX82 (EMBL:D86934) (597 aa) fasta scores: E(): 4.4e-48, 49.823% id in 283 aa. Similar to C-terminal region of SAR0061, 50.530% identity (51.254% ungapped) in 283 aa overlap. Possible C-terminal region of a nonsense mutated protein; hypothetical protein 82706 2860483 SAR0074 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039540.1 81837 R 282458 CDS YP_039541.1 49482317 2860484 complement(82716..83612) 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Staphylococcus aureus hypothetical protein Orf N031 sa0059 TR:Q9KX82 (EMBL:D86934) (597 aa) fasta scores: E(): 2.1e-70, 60.068% id in 293 aa. Similar to N-terminal region of SAR0061, 60.068% identity (60.690% ungapped) in 293 aa overlap. Possible N-terminal region of a nonsense mutated protein; hypothetical protein 83612 2860484 SAR0075 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039541.1 82716 R 282458 CDS YP_039542.1 49482318 2860485 83654..83779 1 NC_002952.2 Doubtful CDS. No significant database hits; hypothetical protein 83779 2860485 SAR0075a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039542.1 83654 D 282458 CDS YP_039543.1 49482319 2860486 complement(83812..84249) 1 NC_002952.2 Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein Orf N009 TR:Q9KX87 (EMBL:D86934) (124 aa) fasta scores: E(): 3.8e-45, 100.000% id in 124 aa CDS is extended at the N-terminus in comparison to the previously sequenced protein. Possible alternative translational start site; hypothetical protein 84249 2860486 SAR0076 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039543.1 83812 R 282458 CDS YP_039544.1 49482320 2860487 complement(84354..84641) 1 NC_002952.2 Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein Orf N008 TR:Q9KX88 (EMBL:D86934) (95 aa) fasta scores: E(): 2.8e-37, 98.947% id in 95 aa; hypothetical protein 84641 2860487 SAR0077 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039544.1 84354 R 282458 CDS YP_039545.1 49482321 2860488 complement(84731..85357) 1 NC_002952.2 Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein Orf N007 TR:Q9KX89 (EMBL:D86934) (208 aa) fasta scores: E(): 1.1e-78, 100.000% id in 208 aa; hypothetical protein 85357 2860488 SAR0078 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039545.1 84731 R 282458 CDS YP_039546.1 49482322 2860489 85472..86980 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical protein TR:Q9XBB4 (EMBL:D86934) (502 aa) fasta scores: E(): 9e-192, 99.801% id in 502 aa. Similar to Lactococcus lactis serine/threonine protein kinase PknB TR:Q9CEF5 (EMBL:AE006418) (627 aa) fasta scores: E(): 2.1e-13, 28.527% id in 319 aa. C-terminus is similar to SAR0083, 50.000% identity (50.000% ungapped) in 52 aa overlap; protein kinase 86980 2860489 SAR0079 Staphylococcus aureus subsp. aureus MRSA252 protein kinase YP_039546.1 85472 D 282458 CDS YP_039547.1 49482323 2860490 87145..89265 1 NC_002952.2 No significant database matches to the full length CDS. Similar to internal regions of Saccharomyces cerevisiae intracellular protein transport protein Uso1 SW:USO1_YEAST (P25386) (1790 aa) fasta scores: E(): 6.7e-06, 21.105% id in 706 aa, and to Plasmodium chabaudi repeat organellar protein TR:Q25662 (EMBL:U43145) (1939 aa) fasta scores: E(): 0.00059, 23.381% id in 556 aa; hypothetical protein 89265 2860490 SAR0080 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039547.1 87145 D 282458 CDS YP_039548.1 49482324 2860491 89496..89795 1 NC_002952.2 Similar to Bacillus halodurans transposase TR:Q9JWP9 (EMBL:AP001518) (94 aa) fasta scores: E(): 7e-19, 62.637% id in 91 aa, and to Enterococcus faecium transposase TR:O69430 (EMBL:AJ223633) (96 aa) fasta scores: E(): 4.2e-18, 63.736% id in 91 aa; transposase 89795 2860491 SAR0081 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_039548.1 89496 D 282458 CDS YP_039549.1 49482325 2860492 89837..90643 1 NC_002952.2 Similar to Bacillus halodurans transposase TR:Q9JWR5 (EMBL:AP001518) (261 aa) fasta scores: E(): 2e-49, 52.453% id in 265 aa, and to Enterococcus faecium transposase TR:O69429 (EMBL:AJ223633) (282 aa) fasta scores: E(): 1.9e-45, 53.252% id in 246 aa; transposase 90643 2860492 SAR0082 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_039549.1 89837 D 282458 CDS YP_039550.1 49482326 2860494 90831..91346 1 NC_002952.2 Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47138 (EMBL:AB047239) (171 aa) fasta scores: E(): 4.7e-63, 100.000% id in 171 aa; hypothetical protein 91346 2860494 SAR0084 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039550.1 90831 D 282458 CDS YP_039551.1 49482327 2860495 complement(91351..92298) 1 NC_002952.2 Identical to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 2.6e-127, 100.000% id in 315 aa, and similar to Bacillus halodurans transposase BH3950 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 2.9e-71, 58.413% id in 315 aa; transposase 92298 2860495 SAR0085 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_039551.1 91351 R 282458 CDS YP_039552.1 49482328 2860496 92484..92858 1 NC_002952.2 Poor database matches. N-terminal region is identical to Staphylococcus aureus hypothetical protein TR:BAB47137 (EMBL:AB047239) (82 aa) fasta scores: E(): 8.8e-27, 100.000% id in 82 aa. Similar to internal region of Saccharomyces cerevisiae hypothetical protein O5254 SW:YO7T_YEAST (Q08647) (676 aa) fasta scores: E(): 7, 31.000% id in 100 aa; hypothetical protein 92858 2860496 SAR0086 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039552.1 92484 D 282458 CDS YP_039553.1 49482329 2860497 93145..94848 1 NC_002952.2 C-terminal region is similar to the C-terminus of Escherichia coli 5-methylcytosine-specific restriction enzyme B McrB SW:MCRB_ECOLI (P15005) (459 aa) fasta scores: E(): 6.8e-41, 47.284% id in 313 aa, and to an internal region of Campylobacter jejuni endonuclease CJ0139 TR:Q9PIY8 (EMBL:AL139074) (783 aa) fasta scores: E(): 7.2e-13, 26.962% id in 586 aa; restriction enzyme 94848 2860497 SAR0087 Staphylococcus aureus subsp. aureus MRSA252 restriction enzyme YP_039553.1 93145 D 282458 CDS YP_039554.1 49482330 2860498 94841..95881 1 NC_002952.2 McrC protein together with McrB forms the McrBC restriction system; recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines); appears to act against 5-methylcytosine preceded by a purine residue; MrcC modulates the specificty of McrB and has DNA cleavage activity; 5-methylcytosine-specific restriction enzyme subunit McrC 95881 2860498 SAR0088 Staphylococcus aureus subsp. aureus MRSA252 5-methylcytosine-specific restriction enzyme subunit McrC YP_039554.1 94841 D 282458 CDS YP_039555.1 49482331 2859710 96110..96208 1 NC_002952.2 hypothetical protein 96208 2859710 SAR0089 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039555.1 96110 D 282458 CDS YP_039556.1 49482332 2859711 96312..96470 1 NC_002952.2 hypothetical protein 96470 2859711 SAR0090 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039556.1 96312 D 282458 CDS YP_039557.1 49482333 2859712 complement(96778..96909) 1 NC_002952.2 Similar to C-terminal regions of Mycobacterium tuberculosis insertion sequence IS1534 protein IstB TR:AAK48099 (EMBL:AE007172) (248 aa) fasta scores: E(): 0.0017, 46.875% id in 32 aa, and to Escherichia coli insertion sequence IS21 ATP-binding protein IstB SW:ISTB_ECOLI (P15026) (265 aa) fasta scores: E(): 0.0062, 44.118% id in 34 aa. Probable gene remnant; insertion sequence protein 96909 2859712 SAR0091 Staphylococcus aureus subsp. aureus MRSA252 insertion sequence protein YP_039557.1 96778 R 282458 CDS YP_039558.1 49482334 2859713 complement(97309..98280) 1 NC_002952.2 Similar to Arthrobacter keyseri oxalomesaconate hydratase PcmD TR:Q9AGL5 (EMBL:AF331043) (342 aa) fasta scores: E(): 5e-05, 23.607% id in 305 aa, and to Synechocystis sp hypothetical protein SLR0619 TR:Q55861 (EMBL:D64004) (348 aa) fasta scores: E(): 5.6e-12, 25.157% id in 318 aa; hydratase 98280 2859713 SAR0092 Staphylococcus aureus subsp. aureus MRSA252 hydratase YP_039558.1 97309 R 282458 CDS YP_039559.1 49482335 2859714 complement(98333..98704) 1 NC_002952.2 Poor database matches. N-terminal region is similar to Staphylococcus carnosus hypothetical protein TR:O54485 (EMBL:U96107) (61 aa) fasta scores: E(): 0.005, 36.066% id in 61 aa; hypothetical protein 98704 2859714 SAR0093 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039559.1 98333 R 282458 CDS YP_039560.1 49482336 2859715 complement(98724..100085) 1 NC_002952.2 Similar to Bacillus subtilis homologue of possible multidrug resistance protein YcnB TR:P94422 (EMBL:D50453) (472 aa) fasta scores: E(): 2.7e-75, 48.444% id in 450 aa, and to Corynebacterium glutamicum possible lincomycin resistance protein LmrB TR:Q9L6D2 (EMBL:AF237667) (481 aa) fasta scores: E(): 1.1e-52, 36.564% id in 454 aa; transporter protein 100085 2859715 SAR0094 Staphylococcus aureus subsp. aureus MRSA252 transporter protein YP_039560.1 98724 R 282458 CDS YP_039561.1 49482337 2859717 101081..101656 1 NC_002952.2 Similar to Vibrio cholerae hemagglutinin/protease regulatory protein HapR TR:O30343 (EMBL:AF000716) (203 aa) fasta scores: E(): 0.24, 23.858% id in 197 aa, and to Pasteurella multocida hypothetical protein PM1155 TR:Q9CLQ9 (EMBL:AE006156) (199 aa) fasta scores: E(): 0.028, 23.280% id in 189 aa; DNA-binding protein 101656 2859717 SAR0097 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_039561.1 101081 D 282458 CDS YP_039562.1 49482338 2859718 102126..102599 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YxbD SW:YXBD_BACSU (P46328) (159 aa) fasta scores: E(): 4.6e-16, 43.046% id in 151 aa, and to Bacillus subtilis hypothetical protein YdhI SW:YDHI_BACSU (O05501) (160 aa) fasta scores: E(): 4e-16, 40.132% id in 152 aa; acetyltransferase (GNAT) family protein 102599 2859718 SAR0098 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_039562.1 102126 D 282458 CDS YP_039563.1 49482339 2859719 complement(102706..103692) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfjN TR:O31546 (EMBL:Z99108) (325 aa) fasta scores: E(): 1.2e-101, 75.385% id in 325 aa, and to Borrelia burgdorferi histidine phosphokinase/phophatase BB0737 TR:O51679 (EMBL:AE001173) (335 aa) fasta scores: E(): 1.2e-31, 36.677% id in 319 aa; hypothetical protein 103692 2859719 SAR0099 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039563.1 102706 R 282458 CDS YP_039564.1 49482340 2859720 104041..104202 1 NC_002952.2 Similar to internal regions of Sulfolobus solfataricus cobalamin biosynthesis protein B CbiB TR:AAK43329 (EMBL:AE006912) (305 aa) fasta scores: E(): 1.9, 30.612% id in 49 aa, and Methanococcus jannaschii hypothetical protein MJ0139 SW:Y139_METJA (Q57603) (209 aa) fasta scores: E(): 2.4, 35.417% id in 48 aa; hypothetical protein 104202 2859720 SAR0100 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039564.1 104041 D 282458 CDS YP_039565.1 49482341 2859721 104251..104547 1 NC_002952.2 Poor database matches. N-terminal region is similar to the N-terminus of Spirochaeta aurantia hypothetical protein SW:YTR3_SPIAU (P22043) (115 aa) fasta scores: E(): 1.5e-05, 35.366% id in 82 aa; hypothetical protein 104547 2859721 SAR0101 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039565.1 104251 D 282458 CDS YP_039566.1 49482342 2859064 104746..105357 1 NC_002952.2 Poor database matches. Similar to internal region of Sulfolobus solfataricus multidrug resistance related protein SSO0548 TR:AAK40865 (EMBL:AE006685) (393 aa) fasta scores: E(): 1.8, 26.066% id in 211 aa, and to C-terminus of Coxiella burnetii cell division protein FtsW TR:Q9XCY0 (EMBL:AF123260) (372 aa) fasta scores: E(): 4.5, 22.872% id in 188 aa; hypothetical protein 105357 2859064 SAR0102 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039566.1 104746 D 282458 CDS YP_039567.1 49482343 2860806 105625..108777 1 NC_002952.2 Internal region is similar to an internal region of Plasmodium falciparum hypothetical protein PFB0765W TR:O96246 (EMBL:AE001417) (980 aa) fasta scores: E(): 0.052, 23.104% id in 567 aa, and to N-terminal region of Sulfolobus solfataricus purine NTPase SSO2249 TR:AAK42417 (EMBL:AE006829) (864 aa) fasta scores: E(): 0.068, 23.700% id in 654 aa. Contains coiled-coiled domain, residues 621 to 644; hypothetical protein 108777 2860806 SAR0103 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039567.1 105625 D 282458 CDS YP_039568.1 49482344 2860807 108860..109342 1 NC_002952.2 hypothetical protein 109342 2860807 SAR0104 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039568.1 108860 D 282458 CDS YP_039569.1 49482345 2859908 109547..110533 1 NC_002952.2 Similar to Staphylococcus aureus 1-phosphatidylinositol phosphodiesterase precursor Plc SW:PLC_STAAU (P45723) (311 aa) fasta scores: E(): 4.6e-114, 95.833% id in 312 aa, and to Bacillus cereus 1-phosphatidylinositol phosphodiesterase precursor SW:PLC_BACCE (P14262) (329 aa) fasta scores: E(): 5.4e-22, 38.650% id in 326 aa; 1-phosphatidylinositol phosphodiesterase 110533 plc 2859908 plc Staphylococcus aureus subsp. aureus MRSA252 1-phosphatidylinositol phosphodiesterase YP_039569.1 109547 D 282458 CDS YP_039570.1 49482346 2860808 110754..111524 1 NC_002952.2 No database matches. Similar to several Staphylococcus aureus CDSs, SAR2570, 63.320% identity (64.314% ungapped) in 259 aa overlap, SAR0444, 63.118% identity (65.613% ungapped) in 263 aa overlap, SAR2573, 59.846% identity (61.265% ungapped) in 259 aa overlap and SAR0445, 50.000% identity (53.571% ungapped) in 270 aa overlap; lipoprotein 111524 2860808 SAR0106 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039570.1 110754 D 282458 CDS YP_039571.1 49482347 2860809 111618..113855 1 NC_002952.2 No significant database matches to the full length CDS. N-terminal region is similar to Erwinia chrysanthemi arabinose operon regulatory protein AraC SW:ARAC_ERWCH (P07642) (310 aa) fasta scores: E(): 1.4e-07, 23.755% id in 261 aa, and Bacillus subtilis hypothetical protein YbfI TR:O31449 (EMBL:Z99105) (275 aa) fasta scores: E(): 1.6e-12, 29.707% id in 239 aa; regulatory protein 113855 2860809 SAR0107 Staphylococcus aureus subsp. aureus MRSA252 regulatory protein YP_039571.1 111618 D 282458 CDS YP_039572.1 49482348 2860810 114006..115184 1 NC_002952.2 Similar to Lactococcus lactis aminoacylase Amd1 TR:Q9L9P4 (EMBL:AF168363) (398 aa) fasta scores: E(): 8.3e-79, 53.368% id in 386 aa, and to Bacillus halodurans N-acyl-L-amino acid amidohydrolase BH1613 TR:Q9KCF8 (EMBL:AP001512) (404 aa) fasta scores: E(): 3.7e-62, 45.153% id in 392 aa; peptidase 115184 2860810 SAR0108 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_039572.1 114006 D 282458 CDS YP_039573.1 49482349 2860811 115186..116574 1 NC_002952.2 Similar to Streptomyces virginiae virginiamycin S resistance protein VarS TR:Q9XE01 (EMBL:AB019519) (518 aa) fasta scores: E(): 3.6e-23, 26.957% id in 460 aa, and to Streptomyces coelicolor transmembrane efflux protein SCH10.26C TR:Q9X8R5 (EMBL:AL049754) (484 aa) fasta scores: E(): 5.6e-24, 27.115% id in 461 aa. Similar to SAR1448, 71.082% identity (71.082% ungapped) in 453 aa overlap and SAR2534, 59.913% identity (60.706% ungapped) in 459 aa overlap; transporter protein 116574 2860811 SAR0109 Staphylococcus aureus subsp. aureus MRSA252 transporter protein YP_039573.1 115186 D 282458 CDS YP_039574.1 49482350 2860812 complement(117060..118727) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1407 TR:Q9KD12 (EMBL:AP001511) (543 aa) fasta scores: E(): 6.4e-87, 48.339% id in 542 aa, and to Streptococcus pyogenes hypothetical protein SPY1695 TR:Q99YH9 (EMBL:AE006599) (543 aa) fasta scores: E(): 1.2e-74, 43.438% id in 541 aa; Na+/Pi-cotransporter protein 118727 2860812 SAR0110 Staphylococcus aureus subsp. aureus MRSA252 Na+/Pi-cotransporter protein YP_039574.1 117060 R 282458 CDS YP_039575.1 49482351 2860813 complement(119046..120821) 1 NC_002952.2 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever; myosin-cross-reactive antigen 120821 2860813 SAR0111 Staphylococcus aureus subsp. aureus MRSA252 myosin-cross-reactive antigen YP_039575.1 119046 R 282458 CDS YP_039576.1 49482352 2860814 121172..121645 1 NC_002952.2 Poor database matches. Similar to Archaeoglobus fulgidus hypothetical protein AF0163 TR:O30074 (EMBL:AE001095) (183 aa) fasta scores: E(): 0.16, 27.333% id in 150 aa, and to Mycoplasma pulmonis hypothetical protein TR:CAC13365 (EMBL:AL445563) (167 aa) fasta scores: E(): 3.5, 27.481% id in 131 aa; hypothetical protein 121645 2860814 SAR0112 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039576.1 121172 D 282458 CDS YP_039577.1 49482353 2859806 121907..123499 1 NC_002952.2 Similar to Escherichia coli L-lactate permease LldP SW:LLDP_ECOLI (P33231) (551 aa) fasta scores: E(): 1.2e-49, 43.414% id in 539 aa, and to Bacillus halodurans L-lactate permease LctP TR:Q9K5Z9 (EMBL:AP001520) (524 aa) fasta scores: E(): 2.3e-115, 59.322% id in 531 aa. Similar to SAR2455, 65.977% identity (66.352% ungapped) in 532 aa overlap; L-lactate permease 1 123499 lldP1 2859806 lldP1 Staphylococcus aureus subsp. aureus MRSA252 L-lactate permease 1 YP_039577.1 121907 D 282458 CDS YP_039578.1 49482354 2859152 complement(123828..125378) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus immunoglobulin G binding protein A precursor Spa SW:SPA2_STAAU (P38507) (508 aa) fasta scores: E(): 1.6e-150, 98.062% id in 516 aa. Similar to Staphylococcus carnosus human serum albumin-binding cell surface precursor PPMABPXM TR:Q53833 (EMBL:U15516) (666 aa) fasta scores: E(): 2.6e-53, 50.484% id in 517 aa. Probable LPXTG-sorted surface protein; immunoglobulin G binding protein A precursor 125378 spa 2859152 spa Staphylococcus aureus subsp. aureus MRSA252 immunoglobulin G binding protein A precursor YP_039578.1 123828 R 282458 CDS YP_039579.1 49482355 2860815 complement(125799..126551) 1 NC_002952.2 C-terminus is similar to Staphylococcus aureus staphylococcal accessory regulator A SarA TR:Q53777 (EMBL:U46541) (113 aa) fasta scores: E(): 1.1e-07, 35.849% id in 106 aa. Full length CDS is similar to Staphylococcus aureus Rot-like protein, agr locus activator, Rlp TR:Q9EZK4 (EMBL:AF288788) (247 aa) fasta scores: E(): 1.9e-29, 38.683% id in 243 aa; regulatory protein 126551 2860815 SAR0115 Staphylococcus aureus subsp. aureus MRSA252 regulatory protein YP_039579.1 125799 R 282458 CDS YP_039580.1 49482356 2859147 complement(126920..127918) 1 NC_002952.2 Similar to Erwinia chrysanthemi achromobactin ABC transporter permease CbrC SW:CBRC_ERWCH (Q47086) (349 aa) fasta scores: E(): 3.1e-36, 37.309% id in 327 aa. Previously sequenced as Staphylococcus aureus siderophore transport protein SirC TR:O87493 (EMBL:AF079518) (332 aa) fasta scores: E(): 7.1e-108, 97.289% id in 332 aa; siderophore ABC transporter permease 127918 sirC 2859147 sirC Staphylococcus aureus subsp. aureus MRSA252 siderophore ABC transporter permease YP_039580.1 126920 R 282458 CDS YP_039581.1 49482357 2859146 complement(127915..128910) 1 NC_002952.2 Similar to Erwinia chrysanthemi achromobactin ABC transporter permease CbrB SW:CBRB_ERWCH (Q47085) (340 aa) fasta scores: E(): 1.5e-44, 43.077% id in 325 aa. Previously sequenced as Staphylococcus aureus siderophore transport protein SirB TR:O87492 (EMBL:AF079518) (331 aa) fasta scores: E(): 5.9e-109, 99.396% id in 331 aa; siderophore ABC transporter permease 128910 sirB 2859146 sirB Staphylococcus aureus subsp. aureus MRSA252 siderophore ABC transporter permease YP_039581.1 127915 R 282458 CDS YP_039582.1 49482358 2859145 complement(128926..129918) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus iron-regulated lipoprotein SirA TR:O87491 (EMBL:AF079518) (330 aa) fasta scores: E(): 6.5e-114, 99.697% id in 330 aa. Similar to Erwinia chrysanthemi achromobactin-binding periplasmic protein precursor CbrA SW:CBRA_ERWCH (Q47084) (305 aa) fasta scores: E(): 3.2e-28, 36.431% id in 269 aa; lipoprotein 129918 sirA 2859145 sirA Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039582.1 128926 R 282458 CDS YP_039583.1 49482359 2860816 130149..131129 1 NC_002952.2 Similar to Alcaligenes eutrophus cysteine synthase CysM SW:CYSM_ALCEU (Q44004) (339 aa) fasta scores: E(): 2.3e-48, 45.231% id in 325 aa, and to Helicobacter pylori J99 cysteine synthase CysM SW:CYSM_HELPJ (Q9ZMW6) (305 aa) fasta scores: E(): 4e-30, 34.098% id in 305 aa; pyridoxal-phosphate dependent protein 131129 2860816 SAR0119 Staphylococcus aureus subsp. aureus MRSA252 pyridoxal-phosphate dependent protein YP_039583.1 130149 D 282458 CDS YP_039584.1 49482360 2860817 131126..132136 1 NC_002952.2 Similar to Rhizobium meliloti ornithine cyclodeaminase Ocd SW:OCD_RHIME (P33728) (320 aa) fasta scores: E(): 3e-14, 22.727% id in 330 aa, and to Archaeoglobus fulgidus ornithine cyclodeaminase AF1665 TR:O28608 (EMBL:AE000988) (322 aa) fasta scores: E(): 2.5e-25, 31.953% id in 338 aa; ornithine cyclodeaminase 132136 2860817 SAR0120 Staphylococcus aureus subsp. aureus MRSA252 ornithine cyclodeaminase YP_039584.1 131126 D 282458 CDS YP_039585.1 49482361 2860818 132157..133911 1 NC_002952.2 C-terminal region is similar to C-terminus of Escherichia coli aerobactin siderophore biosynthesis protein IucC SW:IUCC_ECOLI (Q47318) (580 aa) fasta scores: E(): 6.1e-10, 25.926% id in 459 aa. Full length CDS is similar to Bacillus halodurans hypothetical protein BH2618 TR:Q9K9M7 (EMBL:AP001516) (601 aa) fasta scores: E(): 3.1e-13, 22.165% id in 582 aa; siderophore biosynthesis protein 133911 2860818 SAR0121 Staphylococcus aureus subsp. aureus MRSA252 siderophore biosynthesis protein YP_039585.1 132157 D 282458 CDS YP_039586.1 49482362 2860819 133904..135160 1 NC_002952.2 Similar to Streptococcus pneumoniae multi-drug resistance efflux pump PmrA TR:Q9ZEX9 (EMBL:AJ007367) (399 aa) fasta scores: E(): 3.4e-23, 25.123% id in 406 aa, and to Lactococcus lactis multidrug resistance efflux pump PmrB TR:Q9CJ75 (EMBL:AE006250) (398 aa) fasta scores: E(): 6e-29, 26.873% id in 387 aa; transport protein 135160 2860819 SAR0122 Staphylococcus aureus subsp. aureus MRSA252 transport protein YP_039586.1 133904 D 282458 CDS YP_039587.1 49482363 2860820 135150..136886 1 NC_002952.2 Similar to Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhsC SW:RHSC_RHIME (Q9Z3R0) (585 aa) fasta scores: E(): 2.6e-31, 26.723% id in 595 aa, and to Escherichia coli aerobactin siderophore biosynthesis protein IucA SW:IUCA_ECOLI (Q47316) (575 aa) fasta scores: E(): 3.4e-23, 23.639% id in 588 aa; siderophore biosynthesis protein 136886 2860820 SAR0123 Staphylococcus aureus subsp. aureus MRSA252 siderophore biosynthesis protein YP_039587.1 135150 D 282458 CDS YP_039588.1 49482364 2860821 136867..138645 1 NC_002952.2 Similar to Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhsF SW:RHSF_RHIME (Q9Z3Q7) (601 aa) fasta scores: E(): 3.5e-43, 28.571% id in 560 aa, and to Escherichia coli aerobactin siderophore biosynthesis protein IucC SW:IUCC_ECOLI (Q47318) (580 aa) fasta scores: E(): 1.1e-28, 24.912% id in 566 aa; siderophore biosynthesis protein 138645 2860821 SAR0124 Staphylococcus aureus subsp. aureus MRSA252 siderophore biosynthesis protein YP_039588.1 136867 D 282458 CDS YP_039589.1 49482365 2860822 138620..139396 1 NC_002952.2 Similar to Escherichia coli 5-keto-4-deoxy-D-glucarate aldolase GarL SW:GARL_ECOLI (P23522) (256 aa) fasta scores: E(): 3.2e-17, 29.832% id in 238 aa, and to Rhizobium loti 4-hydroxy-2-oxovalerate aldolase MLL5426 TR:BAB51880 (EMBL:AP003006) (264 aa) fasta scores: E(): 1.5e-21, 34.956% id in 226 aa; aldolase 139396 2860822 SAR0125 Staphylococcus aureus subsp. aureus MRSA252 aldolase YP_039589.1 138620 D 282458 CDS YP_039590.1 49482366 2860302 139396..140598 1 NC_002952.2 Similar to Pseudomonas fluorescens diaminopimelate decarboxylase LysA SW:DCDA_PSEFL (O05321) (416 aa) fasta scores: E(): 5.1e-16, 27.671% id in 365 aa, and to Bacillus circulans butirosin-biosynthetic gene cluster protein BtrK TR:Q9F1Z3 (EMBL:AB033991) (428 aa) fasta scores: E(): 4.8e-30, 31.152% id in 382 aa; pyridoxal-dependent decarboxylase 140598 2860302 SAR0126 Staphylococcus aureus subsp. aureus MRSA252 pyridoxal-dependent decarboxylase YP_039590.1 139396 D 282458 CDS YP_039591.1 49482367 2860303 140602..141366 1 NC_002952.2 hypothetical protein 141366 2860303 SAR0127 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039591.1 140602 D 282458 CDS YP_039592.1 49482368 2860304 141562..142188 1 NC_002952.2 hypothetical protein 142188 2860304 SAR0128 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039592.1 141562 D 282458 CDS YP_039593.1 49482369 2860305 142399..143175 1 NC_002952.2 Similar to Lactococcus lactis diacetyl-acetoin reductase Dar TR:Q9RLV7 (EMBL:AJ012388) (256 aa) fasta scores: E(): 2.4e-38, 48.221% id in 253 aa, and to Klebsiella pneumoniae acetoin BudC SW:BUDC_KLEPN (Q48436) (256 aa) fasta scores: E(): 4e-53, 58.893% id in 253 aa; acetoin reductase 143175 2860305 SAR0129 Staphylococcus aureus subsp. aureus MRSA252 acetoin reductase YP_039593.1 142399 D 282458 CDS YP_039594.1 49482370 2860307 complement(143224..143337) 1 NC_002952.2 Doubtful CDS. No significant database hits; hypothetical protein 143337 2860307 SAR0130a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039594.1 143224 R 282458 CDS YP_039595.1 49482371 2860306 143519..144490 1 NC_002952.2 Similar to Salmonella typhi Vi antigen polysaccharide biosynthesis protein VipB SW:VIPB_SALTI (Q04973) (348 aa) fasta scores: E(): 1.3e-27, 34.756% id in 328 aa, and to Lactococcus lactis UDP-glucose 4-epimerase YcbD TR:Q9CIZ5 (EMBL:AE006259) (313 aa) fasta scores: E(): 9.7e-48, 41.967% id in 305 aa; NAD dependent epimerase/dehydratase 144490 2860306 SAR0130 Staphylococcus aureus subsp. aureus MRSA252 NAD dependent epimerase/dehydratase YP_039595.1 143519 D 282458 CDS YP_039596.1 49482372 2860308 144453..145142 1 NC_002952.2 Similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5M TR:P95706 (EMBL:U81973) (185 aa) fasta scores: E(): 1.7e-21, 41.622% id in 185 aa, and to Bacillus halodurans teichuronic acid biosynthesis protein TuaA TR:Q9K6S6 (EMBL:AP001519) (205 aa) fasta scores: E(): 1.2e-24, 47.531% id in 162 aa; sugar transferase 145142 2860308 SAR0131 Staphylococcus aureus subsp. aureus MRSA252 sugar transferase YP_039596.1 144453 D 282458 CDS YP_039597.1 49482373 2860309 145352..146518 1 NC_002952.2 Similar to Streptococcus pneumoniae galactosyl transferase Cap8H TR:Q9X9A5 (EMBL:AJ239004) (354 aa) fasta scores: E(): 3.2e-08, 24.510% id in 306 aa, and to Thermotoga maritima lipopolysaccharide biosynthesis protein TM0622 TR:Q9WZ90 (EMBL:AE001736) (388 aa) fasta scores: E(): 1.9e-10, 25.000% id in 396 aa; galactosyl transferase 146518 2860309 SAR0132 Staphylococcus aureus subsp. aureus MRSA252 galactosyl transferase YP_039597.1 145352 D 282458 CDS YP_039598.1 49482374 2860310 146499..147737 1 NC_002952.2 Similar to Streptococcus pneumoniae type 2 capsular polysaccharide biosynthesis protein Cps2H TR:Q9ZII1 (EMBL:AF026471) (387 aa) fasta scores: E(): 0.00016, 23.558% id in 416 aa, and to Actinobacillus actinomycetemcomitans (Haemophilus actinomycetemcomitans) serotype d-specific polysaccharide biosynthetesis protein TR:Q9JRS0 (EMBL:AB041266) (431 aa) fasta scores: E(): 0.0017, 21.362% id in 426 aa; hypothetical protein 147737 2860310 SAR0133 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039598.1 146499 D 282458 CDS YP_039599.1 49482375 2860311 147727..149157 1 NC_002952.2 Similar to Yersinia enterocolitica lipopolysaccharide O-unit flippase TrsA TR:Q56913 (EMBL:Z47767) (418 aa) fasta scores: E(): 7.6e-18, 24.257% id in 404 aa, and to Streptococcus thermophilus hypothetical protein EpsI TR:AAK61904 (EMBL:AF373595) (471 aa) fasta scores: E(): 5.2e-46, 30.917% id in 469 aa; polysaccharide biosynthesis protein 149157 2860311 SAR0134 Staphylococcus aureus subsp. aureus MRSA252 polysaccharide biosynthesis protein YP_039599.1 147727 D 282458 CDS YP_039600.1 49482376 2859151 149425..150024 1 NC_002952.2 Previously sequenced as Staphylococcus aureus superoxide dismutase SodM TR:Q9EZZ2 (EMBL:AF273269) (187 aa) fasta scores: E(): 6.2e-77, 100.000% id in 187 aa. Similar to Staphylococcus xylosus superoxide dismutase Sod TR:Q9K4V3 (EMBL:AJ276960) (199 aa) fasta scores: E(): 2.5e-65, 76.382% id in 199 aa. Similar to SAR1630, 74.874% identity (74.874% ungapped) in 199 aa overlap; superoxide dismutase 150024 sodM 2859151 sodM Staphylococcus aureus subsp. aureus MRSA252 superoxide dismutase YP_039600.1 149425 D 282458 CDS YP_039601.1 49482377 2859121 150393..151058 1 NC_002952.2 No significant database matches. Possible LPXAG-sorted surface protein; surface anchored protein 151058 sasD 2859121 sasD Staphylococcus aureus subsp. aureus MRSA252 surface anchored protein YP_039601.1 150393 D 282458 CDS YP_039602.1 49482378 2860312 complement(151160..151900) 1 NC_002952.2 Similar to Pseudomonas fluorescens transcriptional repressor of the trehalose operon TreR TR:Q9F8X4 (EMBL:AF229829) (234 aa) fasta scores: E(): 7.1e-05, 26.267% id in 217 aa, and to Streptococcus pyogenes transcriptional regulator SPY1870 TR:Q99Y48 (EMBL:AE006612) (247 aa) fasta scores: E(): 8.3e-19, 28.879% id in 232 aa; GntR family transcriptional regulator 151900 2860312 SAR0137 Staphylococcus aureus subsp. aureus MRSA252 GntR family transcriptional regulator YP_039602.1 151160 R 282458 CDS YP_039603.1 49482379 2859589 152151..152858 1 NC_002952.2 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 152858 deoD1 2859589 deoD1 Staphylococcus aureus subsp. aureus MRSA252 purine nucleoside phosphorylase YP_039603.1 152151 D 282458 CDS YP_039604.1 49482380 2860313 152865..154217 1 NC_002952.2 Similar to Bacillus subtilis tetracycline resistance protein TetB SW:TCRB_BACSU (P23054) (458 aa) fasta scores: E(): 2.2e-28, 26.201% id in 458 aa, and to Staphylococcus hyicus tetracycline resistance protein Tet SW:TCR_STAHY (P36890) (458 aa) fasta scores: E(): 6.8e-28, 25.764% id in 458 aa; transporter 154217 2860313 SAR0139 Staphylococcus aureus subsp. aureus MRSA252 transporter YP_039604.1 152865 D 282458 CDS YP_039605.1 49482381 2859268 154298..154960 1 NC_002952.2 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 154960 deoC1 2859268 deoC1 Staphylococcus aureus subsp. aureus MRSA252 deoxyribose-phosphate aldolase YP_039605.1 154298 D 282458 CDS YP_039606.1 49482382 2859607 154988..156166 1 NC_002952.2 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 156166 drm 2859607 drm Staphylococcus aureus subsp. aureus MRSA252 phosphopentomutase YP_039606.1 154988 D 282458 CDS YP_039607.1 49482383 2860314 complement(156297..157112) 1 NC_002952.2 Similar to Escherichia coli phosphonates ABC transporter permease PhnE SW:PHNE_ECOLI (P16683) (276 aa) fasta scores: E(): 5.6e-26, 35.341% id in 249 aa, and to Bacillus halodurans phosphonates transporter BH0442 TR:Q9KFN7 (EMBL:AP001508) (267 aa) fasta scores: E(): 8.5e-49, 52.896% id in 259 aa; binding-protein-dependent transport systems membrane component 157112 2860314 SAR0142 Staphylococcus aureus subsp. aureus MRSA252 binding-protein-dependent transport systems membrane component YP_039607.1 156297 R 282458 CDS YP_039608.1 49482384 2860315 complement(157109..157909) 1 NC_002952.2 Similar to Escherichia coli phosphonates ABC transporter permease PhnE SW:PHNE_ECOLI (P16683) (276 aa) fasta scores: E(): 2.3e-27, 36.032% id in 247 aa, and to Bacillus halodurans phosphonates transport system BH0441 TR:Q9KFN8 (EMBL:AP001508) (263 aa) fasta scores: E(): 1.6e-44, 49.615% id in 260 aa; binding-protein-dependent transport system membrane component 157909 2860315 SAR0143 Staphylococcus aureus subsp. aureus MRSA252 binding-protein-dependent transport system membrane component YP_039608.1 157109 R 282458 CDS YP_039609.1 49482385 2860316 complement(157911..158684) 1 NC_002952.2 Similar to Escherichia coli phosphonates transport ATP-binding protein PhnC SW:PHNC_ECOLI (P16677) (262 aa) fasta scores: E(): 2e-30, 43.750% id in 256 aa, and to Bacillus halodurans transporter BH0440 TR:Q9KFN9 (EMBL:AP001508) (257 aa) fasta scores: E(): 4.2e-57, 69.841% id in 252 aa; ABC transporter ATP-binding protein 158684 2860316 SAR0144 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_039609.1 157911 R 282458 CDS YP_039610.1 49482386 2860317 complement(158898..159854) 1 NC_002952.2 Similar to an internal region of Escherichia coli phosphonates-binding periplasmic protein precursor PhnD SW:PHND_ECOLI (P16682) (338 aa) fasta scores: E(): 7.5e-10, 24.101% id in 278 aa. Full length CDS is similar to Bacillus halodurans hypothetical protein BH0439 TR:Q9KFP0 (EMBL:AP001508) (317 aa) fasta scores: E(): 1.4e-55, 54.693% id in 309 aa; lipoprotein 159854 2860317 SAR0145 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039610.1 158898 R 282458 CDS YP_039611.1 49482387 2860318 160083..161627 1 NC_002952.2 No significant database matches to the full length CDS. Internal region of CDS is similar to an internal region Arabidopsis thaliana hypothetical protein F4P12_240 TR:Q9LFG5 (EMBL:AL132966) (932 aa) fasta scores: E(): 1, 24.390% id in 328 aa; hypothetical protein 161627 2860318 SAR0146 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039611.1 160083 D 282458 CDS YP_039612.1 49482388 2860319 161678..163213 1 NC_002952.2 Similar to Escherichia coli 2',3'-cyclic-nucleotide 2'-phosphodiesterase CpdB SW:CN16_ECOLI (P08331) (647 aa) fasta scores: E(): 5.4e-09, 25.279% id in 538 aa, and to Lactococcus lactis phosphatase YcjM TR:Q9CIQ3 (EMBL:AE006267) (519 aa) fasta scores: E(): 7.5e-74, 38.477% id in 512 aa; nucleotidase 163213 2860319 SAR0147 Staphylococcus aureus subsp. aureus MRSA252 nucleotidase YP_039612.1 161678 D 282458 CDS YP_039613.1 49482389 2860320 163370..164137 1 NC_002952.2 Poor database matches. Similar to Borrelia burgdorferi plasmid hypothetical protein TR:Q44710 (EMBL:U03641) (371 aa) fasta scores: E(): 0.89, 22.222% id in 234 aa; hypothetical protein 164137 2860320 SAR0148 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039613.1 163370 D 282458 CDS YP_039614.1 49482390 2860321 164143..165318 1 NC_002952.2 Poor database matches. Similar to Neisseria meningitidis transcriptional regulator NMB2012 TR:Q9JXJ6 (EMBL:AE002551) (363 aa) fasta scores: E(): 3e-09, 25.714% id in 350 aa, and to Mycobacterium tuberculosis DNA-binding protein MT2073 TR:AAK46351 (EMBL:AE007058) (346 aa) fasta scores: E(): 0.0001, 28.012% id in 332 aa; DNA-binding protein 165318 2860321 SAR0149 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_039614.1 164143 D 282458 CDS YP_039615.1 49482391 2860979 165704..168313 1 NC_002952.2 Similar to Escherichia coli aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase, acetaldehyde dehydrogenase and pyruvate-formate-lyase-deactivase] AdhE SW:ADHE_ECOLI (P17547) (890 aa) fasta scores: E(): 3.4e-140, 48.601% id in 858 aa, and to Entamoeba histolytica aldehyde-alcohol dehydrogenase 2 [includes: alcohol dehydrogenase, acetaldehyde dehydrogenase, and pyruvate-formate-lyase-deactivase] Adh2 SW:ADH2_ENTHI (Q24803) (870 aa) fasta scores: E(): 4.8e-170, 52.887% id in 866 aa; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 168313 adhE 2860979 adhE Staphylococcus aureus subsp. aureus MRSA252 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_039615.1 165704 D 282458 CDS YP_039616.1 49482392 2861340 168658..169326 1 NC_002952.2 Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5A TR:P95695 (EMBL:U81973) (222 aa) fasta scores: E(): 1.3e-72, 99.550% id in 222 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8A TR:P72367 (EMBL:U73374) (222 aa) fasta scores: E(): 5.2e-72, 98.649% id in 222 aa, Similar to SAR2745, 52.489% identity (52.727% ungapped) in 221 aa overlap; capsular polysaccharide synthesis enzyme 169326 capA 2861340 capA Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039616.1 168658 D 282458 CDS YP_039617.1 49482393 2861341 169342..170028 1 NC_002952.2 Highly imilar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8B TR:P72368 (EMBL:U73374) (228 aa) fasta scores: E(): 3.8e-77, 96.491% id in 228 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5B TR:P95696 (EMBL:U81973) (228 aa) fasta scores: E(): 1e-76, 95.614% id in 228 aa. Similar to SAR2744, 5.895% identity (56.140% ungapped) in 229 aa overlap; capsular polysaccharide synthesis enzyme 170028 capB 2861341 capB Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039617.1 169342 D 282458 CDS YP_039618.1 49482394 2861342 170031..170795 1 NC_002952.2 Highly imilar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8C TR:P72369 (EMBL:U73374) (254 aa) fasta scores: E(): 1.5e-96, 99.213% id in 254 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5C TR:P95697 (EMBL:U81973) (254 aa) fasta scores: E(): 4.2e-96, 98.425% id in 254 aa. Similar to SAR2743, 52.549% identity (53.175% ungapped) in 255 aa overlap; capsular polysaccharide synthesis enzyme 170795 capC 2861342 capC Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039618.1 170031 D 282458 CDS YP_039619.1 49482395 2861343 170815..172638 1 NC_002952.2 Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5D TR:P95698 (EMBL:U81973) (607 aa) fasta scores: E(): 1.5e-214, 99.012% id in 607 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8D TR:P72370 (EMBL:U73374) (607 aa) fasta scores: E(): 8.4e-214, 98.682% id in 607 aa; capsular polysaccharide synthesis enzyme 172638 capD 2861343 capD Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039619.1 170815 D 282458 CDS YP_039620.1 49482396 2861344 172628..173656 1 NC_002952.2 Identical to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8E TR:P72371 (EMBL:U73374) (342 aa) fasta scores: E(): 4.3e-127, 100.000% id in 342 aa Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5E TR:P95699 (EMBL:U81973) (342 aa) fasta scores: E(): 1e-126, 99.708% id in 342 aa; capsular polysaccharide synthesis enzyme 173656 capE 2861344 capE Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039620.1 172628 D 282458 CDS YP_039621.1 49482397 2861345 173669..174778 1 NC_002952.2 Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5F TR:P95700 (EMBL:U81973) (371 aa) fasta scores: E(): 3.6e-143, 99.187% id in 369 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8F TR:P72372 (EMBL:U73374) (371 aa) fasta scores: E(): 4.6e-141, 97.832% id in 369 aa; capsular polysaccharide synthesis enzyme 174778 capF 2861345 capF Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039621.1 173669 D 282458 CDS YP_039622.1 49482398 2861346 174782..175906 1 NC_002952.2 Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8G TR:P72373 (EMBL:U73374) (374 aa) fasta scores: E(): 2.2e-139, 99.465% id in 374 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5G TR:P95701 (EMBL:U81973) (374 aa) fasta scores: E(): 9.9e-139, 99.198% id in 374 aa; capsular polysaccharide synthesis enzyme 175906 capG 2861346 capG Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039622.1 174782 D 282458 CDS YP_039623.1 49482399 2861336 175909..176988 1 NC_002952.2 Similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8H TR:P72374 (EMBL:U73374) (359 aa) fasta scores: E(): 2.4e-129, 93.872% id in 359 aa, and to Streptococcus pneumoniae capsular polysaccharide synthesis enzyme O-antigen translocase WciK TR:Q9AHC9 (EMBL:AF316639) (358 aa) fasta scores: E(): 5.2e-26, 31.319% id in 364 aa; capsular polysaccharide synthesis enzyme 176988 cap8H 2861336 cap8H Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039623.1 175909 D 282458 CDS YP_039624.1 49482400 2861337 176981..178375 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8I TR:P72375 (EMBL:U73374) (464 aa) fasta scores: E(): 2e-161, 98.060% id in 464 aa; capsular polysaccharide synthesis enzyme 178375 cap8I 2861337 cap8I Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039624.1 176981 D 282458 CDS YP_039625.1 49482401 2861338 178372..178929 1 NC_002952.2 Identical to aureus capsular polysaccharide synthesis enzyme Cap8J TR:P72376 (EMBL:U73374) (185 aa) fasta scores: E(): 7.2e-73, 100.000% id in 185 aa. C_terminal region is similar to the C-terminus of Vibrio cholerae probable galactoside-O-acetyl transferase WblB TR:O87158 (EMBL:AB012957) (161 aa) fasta scores: E(): 4.6e-10, 38.333% id in 120 aa; capsular polysaccharide synthesis enzyme 178929 cap8J 2861338 cap8J Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039625.1 178372 D 282458 CDS YP_039626.1 49482402 2861339 178938..180176 1 NC_002952.2 Similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8K TR:P72377 (EMBL:U73374) (412 aa) fasta scores: E(): 2.9e-128, 97.573% id in 412 aa, and to Pseudomonas aeruginosa protein O-antigen translocase WbpF TR:P72137 (EMBL:U50396) (411 aa) fasta scores: E(): 3.5e-19, 22.850% id in 407 aa; capsular polysaccharide synthesis enzyme 180176 cap8K 2861339 cap8K Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039626.1 178938 D 282458 CDS YP_039627.1 49482403 2861347 180210..181415 1 NC_002952.2 Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5L TR:P95705 (EMBL:U81973) (401 aa) fasta scores: E(): 1.5e-152, 99.501% id in 401 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8L TR:P72378 (EMBL:U73374) (401 aa) fasta scores: E(): 8.6e-151, 98.005% id in 401 aa; capsular polysaccharide synthesis enzyme 181415 capL 2861347 capL Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039627.1 180210 D 282458 CDS YP_039628.1 49482404 2861348 181426..181983 1 NC_002952.2 Similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5M TR:P95706 (EMBL:U81973) (185 aa) fasta scores: E(): 4.5e-69, 99.459% id in 185 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8M TR:P72379 (EMBL:U73374) (185 aa) fasta scores: E(): 6.1e-69, 98.378% id in 185 aa; capsular polysaccharide synthesis enzyme 181983 capM 2861348 capM Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039628.1 181426 D 282458 CDS YP_039629.1 49482405 2861349 181983..182870 1 NC_002952.2 Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5N TR:P95707 (EMBL:U81973) (295 aa) fasta scores: E(): 1.7e-110, 98.644% id in 295 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8N TR:P72380 (EMBL:U73374) (295 aa) fasta scores: E(): 1.4e-109, 97.966% id in 295 aa; capsular polysaccharide synthesis enzyme 182870 capN 2861349 capN Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039629.1 181983 D 282458 CDS YP_039630.1 49482406 2861350 182924..184186 1 NC_002952.2 Highly imilar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5O TR:P95708 (EMBL:U81973) (420 aa) fasta scores: E(): 3.9e-157, 99.048% id in 420 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8O TR:P72381 (EMBL:U73374) (420 aa) fasta scores: E(): 1.6e-156, 99.048% id in 420 aa; capsular polysaccharide synthesis enzyme 184186 capO 2861350 capO Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039630.1 182924 D 282458 CDS YP_039631.1 49482407 2861351 184233..185408 1 NC_002952.2 Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8P TR:P72382 (EMBL:U73374) (391 aa) fasta scores: E(): 2.4e-146, 98.721% id in 391 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5P TR:P95709 (EMBL:U81973) (391 aa) fasta scores: E(): 2.8e-146, 98.465% id in 391 aa. Similar to SAR2199, 60.372% identity (60.372% ungapped) in 376 aa overlap; capsular polysaccharide synthesis enzyme 185408 capP 2861351 capP Staphylococcus aureus subsp. aureus MRSA252 capsular polysaccharide synthesis enzyme YP_039631.1 184233 D 282458 CDS YP_039632.1 49482408 2860322 complement(185473..185799) 1 NC_002952.2 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source; heme-degrading monooxygenase IsdI 185799 2860322 SAR0167 Staphylococcus aureus subsp. aureus MRSA252 heme-degrading monooxygenase IsdI YP_039632.1 185473 R 282458 CDS YP_039633.1 49482409 2860323 complement(185806..186189) 1 NC_002952.2 Similar to Staphylococcus carnosus hypothetical protein TR:Q9F328 (EMBL:AJ279090) (129 aa) fasta scores: E(): 4.4e-25, 55.118% id in 127 aa, and to Pasteurella multocida hypothetical protein PM0679 TR:Q9CMX2 (EMBL:AE006104) (120 aa) fasta scores: E(): 1.2e-11, 33.333% id in 120 aa; hypothetical protein 186189 2860323 SAR0168 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039633.1 185806 R 282458 CDS YP_039634.1 49482410 2860324 186616..188103 1 NC_002952.2 Similar to Vibrio cholerae aldehyde dehydrogenase AldA SW:DHAL_VIBCH (P23240) (506 aa) fasta scores: E(): 7.5e-81, 44.490% id in 490 aa, and to Alteromonas sp aldehyde dehydrogenase OlgA TR:O50609 (EMBL:AB009654) (505 aa) fasta scores: E(): 8.8e-78, 43.035% id in 481 aa; aldehyde dehydrogenase 188103 2860324 SAR0169 Staphylococcus aureus subsp. aureus MRSA252 aldehyde dehydrogenase YP_039634.1 186616 D 282458 CDS YP_039635.1 49482411 2860325 188750..189709 1 NC_002952.2 Similar to Alcaligenes sp cation efflux system protein CzcD SW:CZCD_ALCSP (P94178) (316 aa) fasta scores: E(): 6.7e-32, 36.458% id in 288 aa, and to Staphylococcus aureus zinc resistance protein CzrB TR:Q9ZNF5 (EMBL:AB016431) (325 aa) fasta scores: E(): 6.9e-38, 41.237% id in 291 aa; cation efflux system protein 189709 2860325 SAR0170 Staphylococcus aureus subsp. aureus MRSA252 cation efflux system protein YP_039635.1 188750 D 282458 CDS YP_039636.1 49482412 2860326 complement(189771..189974) 1 NC_002952.2 hypothetical protein 189974 2860326 SAR0171 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039636.1 189771 R 282458 CDS YP_039637.1 49482413 2860327 190154..190666 1 NC_002952.2 Poor database matches. Similar to Synechococcus sp alpha-helical coiled-coil protein SrpF TR:Q9R6V4 (EMBL:AF176824) (175 aa) fasta scores: E(): 1.8e-21, 42.515% id in 167 aa; hypothetical protein 190666 2860327 SAR0172 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039637.1 190154 D 282458 CDS YP_039638.1 49482414 2860328 191008..191748 1 NC_002952.2 Similar to Synechococcus sp nitrate transport ATP-binding protein NrtD SW:NRTD_SYNP7 (P38046) (274 aa) fasta scores: E(): 9.7e-28, 40.343% id in 233 aa, and to Phormidium laminosum ATP binding protein NrtC-Phl TR:Q51882 (EMBL:Z19598) (625 aa) fasta scores: E(): 7.4e-29, 43.154% id in 241 aa; ABC transporter ATP-binding protein 191748 2860328 SAR0173 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_039638.1 191008 D 282458 CDS YP_039639.1 49482415 2860329 191762..192736 1 NC_002952.2 Internal region of CDS is similar to internal regions of Escherichia coli taurine-binding periplasmic protein precursor TauA SW:TAUA_ECOLI (Q47537) (320 aa) fasta scores: E(): 0.2, 25.410% id in 244 aa, and Escherichia coli aliphatic sulfonates binding protein precursor SsuA SW:SSUA_ECOLI (P75853) (319 aa) fasta scores: E(): 0.00019, 22.509% id in 271 aa; lipoprotein 192736 2860329 SAR0174 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039639.1 191762 D 282458 CDS YP_039640.1 49482416 2860330 192733..193494 1 NC_002952.2 Similar to Escherichia coli taurine ABC transporter permease TauC SW:TAUC_ECOLI (Q47539) (275 aa) fasta scores: E(): 5.2e-22, 29.084% id in 251 aa, and to Pseudomonas aeruginosa probable permease of ABC transporter PA3443 TR:Q9HYG3 (EMBL:AE004765) (262 aa) fasta scores: E(): 6.8e-28, 34.034% id in 238 aa; ABC transporter permease 193494 2860330 SAR0175 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_039640.1 192733 D 282458 CDS YP_039641.1 49482417 2860331 193507..194538 1 NC_002952.2 Similar to Solanum tuberosum isovaleryl-CoA dehydrogenase precursor Ivd1 TR:Q9FS88 (EMBL:AJ278987) (412 aa) fasta scores: E(): 0.14, 19.805% id in 308 aa, and to Neisseria meningitidis acyl-CoA dehydrogenase NMB0994 TR:Q9JZL9 (EMBL:AE002450) (363 aa) fasta scores: E(): 1.2e-22, 30.636% id in 346 aa; hypothetical protein 194538 2860331 SAR0176 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039641.1 193507 D 282458 CDS YP_039642.1 49482418 2860332 194752..195111 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YrhF SW:YRHF_BACSU (O05398) (122 aa) fasta scores: E(): 2.4e-11, 36.937% id in 111 aa. C-terminal region is similar to Bacillus halodurans hypothetical protein BH2529 TR:Q9K9W6 (EMBL:AP001515) (82 aa) fasta scores: E(): 2.1e-06, 44.000% id in 75 aa; hypothetical protein 195111 2860332 SAR0177 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039642.1 194752 D 282458 CDS YP_039643.1 49482419 2860333 195186..196310 1 NC_002952.2 Catalyzes the reversible two-electron oxidation of formate to carbon dioxide. It allows the assimilation of carbon dioxide and provides energy for growth through oxidative phosphorylation coupled to the reduction of oxygen, nitrate, sulphate or fumarate; formate dehydrogenase 196310 2860333 SAR0178 Staphylococcus aureus subsp. aureus MRSA252 formate dehydrogenase YP_039643.1 195186 D 282458 CDS YP_039644.1 49482420 2860205 196696..197946 1 NC_002952.2 Similar to Lactococcus lactis proton motive force-dependent drug transporter LmrP TR:Q48658 (EMBL:X89779) (408 aa) fasta scores: E(): 2.4e-09, 24.096% id in 415 aa, and to Deinococcus radiodurans integral membrane protein LmrP TR:Q9RZS1 (EMBL:AE001826) (432 aa) fasta scores: E(): 2.2e-27, 27.094% id in 406 aa; transporter protein 197946 2860205 SAR0179 Staphylococcus aureus subsp. aureus MRSA252 transporter protein YP_039644.1 196696 D 282458 CDS YP_039645.1 49482421 2860206 198393..205568 1 NC_002952.2 Similar to the N-terminal region of Bacillus licheniformis bacitracin synthetase 3 BacC SW:BACC_BACLI (O68008) (6359 aa) fasta scores: E(): 2.8e-147, 32.871% id in 2093 aa, and to Bacillus subtilis peptide synthetase PpsD TR:P94459 (EMBL:Z34883) (3603 aa) fasta scores: E(): 4.2e-166, 31.103% id in 2122 aa; non-ribosomal peptide synthetase 205568 2860206 SAR0180 Staphylococcus aureus subsp. aureus MRSA252 non-ribosomal peptide synthetase YP_039645.1 198393 D 282458 CDS YP_039646.1 49482422 2860207 205581..206225 1 NC_002952.2 N-terminus is similar to N-terminal regions of Bacillus subtilis lipopeptide antibiotics iturin A and surfactin biosynthesis protein Lpa-14 SW:LP14_BACSU (P39144) (224 aa) fasta scores: E(): 3e-07, 30.682% id in 176 aa, and Bacillus pumilus surfactin synthesis regulator Psf-1 SW:PSF1_BACPU (P55810) (233 aa) fasta scores: E(): 3.6e-07, 30.508% id in 177 aa; 4'-phosphopantetheinyl transferase 206225 2860207 SAR0181 Staphylococcus aureus subsp. aureus MRSA252 4'-phosphopantetheinyl transferase YP_039646.1 205581 D 282458 CDS YP_039647.1 49482423 2860208 complement(206554..207048) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YreD TR:Q9CEZ2 (EMBL:AE006399) (178 aa) fasta scores: E(): 6.7e-30, 47.771% id in 157 aa, and to Campylobacter jejuni integral membrane protein CJ0014C TR:Q9PJ97 (EMBL:AL139074) (174 aa) fasta scores: E(): 8.7e-24, 42.424% id in 165 aa; hypothetical protein 207048 2860208 SAR0182 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039647.1 206554 R 282458 CDS YP_039648.1 49482424 2860209 complement(207318..208088) 1 NC_002952.2 Similar to Bacillus stearothermophilus acetylglutamate kinase ArgB SW:ARGB_BACST (Q07905) (258 aa) fasta scores: E(): 1.8e-24, 35.294% id in 255 aa, and to Bacillus halodurans N-acetylglutamate 5-phosphotransferase ArgB TR:Q9K8V4 (EMBL:AP001517) (260 aa) fasta scores: E(): 3.7e-27, 36.328% id in 256 aa; amino acid kinase 208088 2860209 SAR0183 Staphylococcus aureus subsp. aureus MRSA252 amino acid kinase YP_039648.1 207318 R 282458 CDS YP_039649.1 49482425 2859855 complement(208104..209345) 1 NC_002952.2 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 209345 argJ 2859855 argJ Staphylococcus aureus subsp. aureus MRSA252 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase YP_039649.1 208104 R 282458 CDS YP_039650.1 49482426 2859852 complement(209357..210391) 1 NC_002952.2 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 210391 argC 2859852 argC Staphylococcus aureus subsp. aureus MRSA252 N-acetyl-gamma-glutamyl-phosphate reductase YP_039650.1 209357 R 282458 CDS YP_039651.1 49482427 2860210 complement(210427..211611) 1 NC_002952.2 Similar to the C-terminal region of Rattus norvegicus ornithine aminotransferase precursor protein Oat SW:OAT_RAT (P04182) (439 aa) fasta scores: E(): 1e-68, 46.770% id in 387 aa, and to Bacillus subtilis ornithine aminotransferase RocD SW:OAT_BACSU (P38021) (401 aa) fasta scores: E(): 4.6e-84, 51.151% id in 391 aa. Similar to SAR0919, 57.179% identity (57.179% ungapped) in 390 aa overlap; ornithine aminotransferase 211611 2860210 SAR0186 Staphylococcus aureus subsp. aureus MRSA252 ornithine aminotransferase YP_039651.1 210427 R 282458 CDS YP_039652.1 49482428 2860211 complement(211864..213219) 1 NC_002952.2 Similar to Lactobacillus delbrueckii branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_LACDL (P54104) (446 aa) fasta scores: E(): 1.5e-65, 46.347% id in 438 aa, and to Bacillus subtilis branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_BACSU (P94499) (440 aa) fasta scores: E(): 4.7e-62, 44.196% id in 448 aa; branched-chain amino acid transport system carrier protein 213219 2860211 SAR0187 Staphylococcus aureus subsp. aureus MRSA252 branched-chain amino acid transport system carrier protein YP_039652.1 211864 R 282458 CDS YP_039653.1 49482429 2860212 complement(213486..214043) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwoC TR:P94573 (EMBL:Z82987) (189 aa) fasta scores: E(): 1.5e-29, 48.649% id in 185 aa, and to Escherichia coli hypothetical protein YecD SW:YECD_ECOLI (P37347) (199 aa) fasta scores: E(): 1.5e-20, 40.541% id in 185 aa; isochorismatase 214043 2860212 SAR0188 Staphylococcus aureus subsp. aureus MRSA252 isochorismatase YP_039653.1 213486 R 282458 CDS YP_039654.1 49482430 2860213 complement(214110..215750) 1 NC_002952.2 Similar to Enterobacter cloacae indole-3-pyruvate decarboxylase IpdC SW:DCIP_ENTCL (P23234) (552 aa) fasta scores: E(): 1.6e-73, 39.060% id in 553 aa, and to Pseudomonas putida indolepyruvate decarboxylase IpdC TR:Q9FDC2 (EMBL:AF285632) (546 aa) fasta scores: E(): 2.6e-74, 39.241% id in 553 aa; thiamine pyrophosphate enzyme 215750 2860213 SAR0189 Staphylococcus aureus subsp. aureus MRSA252 thiamine pyrophosphate enzyme YP_039654.1 214110 R 282458 CDS YP_039655.1 49482431 2859916 complement(216022..218067) 1 NC_002952.2 Similar to Staphylococcus carnosus PTS system, glucose-specific IIABC component GlcA TR:Q57071 (EMBL:X93360) (675 aa) fasta scores: E(): 1.8e-187, 75.695% id in 683 aa, and to Bacillus halodurans PTS system, glucose-specific enzyme II, A component BH0844 TR:Q9KEK8 (EMBL:AP001510) (675 aa) fasta scores: E(): 1.8e-144, 59.647% id in 679 aa. Similar to SAR2618, 59.584% identity (61.692% ungapped) in 673 aa overlap; glucose-specific PTS transporter protein, IIABC component 218067 glcA 2859916 glcA Staphylococcus aureus subsp. aureus MRSA252 glucose-specific PTS transporter protein, IIABC component YP_039655.1 216022 R 282458 CDS YP_039656.1 49482432 2860214 218652..219707 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YleB TR:Q9CGG7 (EMBL:AE006345) (353 aa) fasta scores: E(): 1.3e-32, 33.239% id in 355 aa, and to Bacillus halodurans hypothetical protein BH3573 TR:Q9K701 (EMBL:AP001519) (351 aa) fasta scores: E(): 2.9e-27, 31.534% id in 352 aa; hypothetical protein 219707 2860214 SAR0191 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039656.1 218652 D 282458 CDS YP_039657.1 49482433 2860215 219704..220603 1 NC_002952.2 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 220603 murQ 2860215 murQ Staphylococcus aureus subsp. aureus MRSA252 N-acetylmuramic acid 6-phosphate etherase YP_039657.1 219704 D 282458 CDS YP_039658.1 49482434 2860216 220615..222069 1 NC_002952.2 Similar to Salmonella typhimurium PTS system, sucrose-specific IIBC component ScrA SW:PTSB_SALTY (P08470) (456 aa) fasta scores: E(): 1e-28, 31.092% id in 476 aa, and to Lactococcus lactis sucrose-specific PTS system IIBC component YleD TR:Q9CGG5 (EMBL:AE006345) (454 aa) fasta scores: E(): 5.1e-88, 56.710% id in 462 aa; sucrose-specific PTS transporter protein 222069 2860216 SAR0193 Staphylococcus aureus subsp. aureus MRSA252 sucrose-specific PTS transporter protein YP_039658.1 220615 D 282458 CDS YP_039659.1 49482435 2860217 222069..222947 1 NC_002952.2 Similar to Lactococcus lactis transcription regulator YleF TR:Q9CGG3 (EMBL:AE006345) (283 aa) fasta scores: E(): 1.5e-26, 32.971% id in 276 aa, and to Thermotoga maritima hypothetical protein RpiR family transcriptional regulator TM0326 SW:Y326_THEMA (Q9WYG1) (280 aa) fasta scores: E(): 2.8e-19, 29.720% id in 286 aa. Similar to SAR2399, 54.639% identity (54.828% ungapped) in 291 aa overlap; transcriptional regulator 222947 2860217 SAR0194 Staphylococcus aureus subsp. aureus MRSA252 transcriptional regulator YP_039659.1 222069 D 282458 CDS YP_039660.1 49482436 2860218 complement(223142..223423) 1 NC_002952.2 Poor database matches, similar to an internal region of Schizolachnus pineti ATP synthase A chain subunit 6 Atp6 TR:Q9B6H4 (EMBL:AJ298678) (217 aa) fasta scores: E(): 2.1, 30.208% id in 96 aa. Doubtful CDS; hypothetical protein 223423 2860218 SAR0195 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039660.1 223142 R 282458 CDS YP_039661.1 49482437 2860219 223636..226425 1 NC_002952.2 Similar to Escherichia coli type I restriction enzyme EcoR124II R protein HsdR SW:T1R1_ECOLI (P10486) (1033 aa) fasta scores: E(): 3.2e-17, 35.119% id in 1008 aa, and to Helicobacter pylori type I restriction enzyme R protein HP0846 TR:O25517 (EMBL:AE000595) (866 aa) fasta scores: E(): 6.6e-77, 37.355% id in 862 aa; type I restriction enzyme 226425 2860219 SAR0196 Staphylococcus aureus subsp. aureus MRSA252 type I restriction enzyme YP_039661.1 223636 D 282458 CDS YP_039662.1 49482438 2860220 226625..227488 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical 33.2 kDa protein TR:Q9RL83 (EMBL:Y18638) (280 aa) fasta scores: E(): 3.8e-98, 96.774% id in 279 aa. Internal region of the CDS is similar internal region of bacteriophage P4 cII protein SW:RCII_BPP4 (P13059) (264 aa) fasta scores: E(): 0.00028, 26.222% id in 225 aa; hypothetical protein 227488 2860220 SAR0197 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039662.1 226625 D 282458 CDS YP_039663.1 49482439 2860221 complement(227693..229285) 1 NC_002952.2 Similar to Rhizobium meliloti probable ABC transporter ATP-binding protein SMA1434 TR:AAK65441 (EMBL:AE007265) (550 aa) fasta scores: E(): 3.9e-76, 44.318% id in 528 aa, and to Rhizobium loti peptide ABC transporter ATP-binding protein MLL5490 TR:BAB51933 (EMBL:AP003006) (543 aa) fasta scores: E(): 6.8e-72, 43.289% id in 529 aa. Similar to SAR0951, 50.763% identity (50.763% ungapped) in 262 aa overlap; ABC transporter ATP-binding protein 229285 2860221 SAR0198 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_039663.1 227693 R 282458 CDS YP_039664.1 49482440 2860222 229413..230720 1 NC_002952.2 Possible alternative translational start sites. C-terminal region is similar to Bacillus subtilis dipeptide ABC transporter permease DppB SW:DPPB_BACSU (P26903) (308 aa) fasta scores: E(): 8.1e-31, 32.993% id in 294 aa, and Bacillus halodurans oligopeptide ABC transporter BH0029 TR:Q9KGM9 (EMBL:AP001507) (314 aa) fasta scores: E(): 1.4e-36, 39.799% id in 299 aa; ABC transporter permease 230720 2860222 SAR0199 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_039664.1 229413 D 282458 CDS YP_039665.1 49482441 2860223 230726..231889 1 NC_002952.2 C-terminal region is similar to Bacillus firmus dipeptide ABC transporter permease DppC SW:DPPC_BACFI (P94312) (304 aa) fasta scores: E(): 9.3e-41, 40.071% id in 282 aa, and Bacillus halodurans oligopeptide ABC transporter BH0030 TR:Q9KGM8 (EMBL:AP001507) (301 aa) fasta scores: E(): 1.1e-42, 41.971% id in 274 aa. Possible alternative translational start sites; ABC transporter permease 231889 2860223 SAR0200 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_039665.1 230726 D 282458 CDS YP_039666.1 49482442 2859274 231906..233681 1 NC_002952.2 Previously sequenced as Staphylococcus aureus RGD-containing lipoprotein Rlp TR:Q9EY53 (EMBL:AY007316) (591 aa) fasta scores: E(): 2.8e-213, 99.831% id in 591 aa; RGD-containing lipoprotein 233681 rlp 2859274 rlp Staphylococcus aureus subsp. aureus MRSA252 RGD-containing lipoprotein YP_039666.1 231906 D 282458 CDS YP_039667.1 49482443 2860224 233719..235725 1 NC_002952.2 Similar to Bacillus subtilis gamma-glutamyltranspeptidase precursor Ggt SW:GGT_BACSU (P54422) (587 aa) fasta scores: E(): 8.5e-75, 38.532% id in 545 aa, and to Escherichia coli gamma-glutamyltranspeptidase precursor Ggt SW:GGT_ECOLI (P18956) (580 aa) fasta scores: E(): 1.6e-57, 34.615% id in 546 aa. CDS is truncated at the N-terminus and extended at the C-terminus in comparison to the B. subtilis and E. coli proteins; gamma-glutamyltranspeptidase 235725 2860224 SAR0202 Staphylococcus aureus subsp. aureus MRSA252 gamma-glutamyltranspeptidase YP_039667.1 233719 D 282458 CDS YP_039668.1 49482444 2860225 complement(236262..236888) 1 NC_002952.2 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 236888 acpD 2860225 acpD Staphylococcus aureus subsp. aureus MRSA252 azoreductase YP_039668.1 236262 R 282458 CDS YP_039669.1 49482445 2860226 237097..237675 1 NC_002952.2 No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Staphylococcus aureus peptidoglycan hydrolase LytM TR:O33599 (EMBL:L77194) (322 aa) fasta scores: E(): 1.3e-17, 41.791% id in 134 aa, and to Staphylococcus simulans lysostaphin precursor Lss SW:LSTP_STASI (P10547) (493 aa) fasta scores: E(): 4e-17, 40.789% id in 152 aa; peptidase 237675 2860226 SAR0204 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_039669.1 237097 D 282458 CDS YP_039670.1 49482446 2860227 238058..239155 1 NC_002952.2 Similar to Thermococcus litoralis maltose transport protein MalK TR:Q9YGA6 (EMBL:AF121946) (372 aa) fasta scores: E(): 1.4e-60, 52.279% id in 373 aa, and to Bacillus subtilis probable multiple sugar-binding transport ATP-binding protein MsmX SW:MSMX_BACSU (P94360) (365 aa) fasta scores: E(): 1.8e-82, 65.479% id in 365 aa; ABC transporter ATP-binding protein 239155 2860227 SAR0205 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_039670.1 238058 D 282458 CDS YP_039671.1 49482447 2860228 239168..240439 1 NC_002952.2 Similar to Streptococcus pneumoniae maltose/maltodextrin-binding protein precursor MalX SW:MALX_STRPN (P29850) (423 aa) fasta scores: E(): 1.8e-28, 29.535% id in 430 aa, and to Bacillus halodurans maltose/maltodextrin-binding protein BH2926 TR:Q9K8S7 (EMBL:AP001517) (429 aa) fasta scores: E(): 4e-61, 40.610% id in 426 aa; extracellular sugar-binding lipoprotein 240439 2860228 SAR0206 Staphylococcus aureus subsp. aureus MRSA252 extracellular sugar-binding lipoprotein YP_039671.1 239168 D 282458 CDS YP_039672.1 49482448 2860229 240442..241710 1 NC_002952.2 Similar to Streptococcus pneumoniae maltodextrin ABC transporter permease MalC SW:MALC_STRPN (Q04698) (430 aa) fasta scores: E(): 3.1e-69, 44.860% id in 428 aa, and to Bacillus halodurans maltose/maltodextrin ABC transporter permease BH2925 TR:Q9K8S8 (EMBL:AP001517) (430 aa) fasta scores: E(): 2.4e-113, 66.986% id in 418 aa; sugar ABC transporter permease 241710 2860229 SAR0207 Staphylococcus aureus subsp. aureus MRSA252 sugar ABC transporter permease YP_039672.1 240442 D 282458 CDS YP_039673.1 49482449 2860230 241712..242551 1 NC_002952.2 Similar to Streptococcus pneumoniae maltodextrin ABC transporter permease MalD SW:MALD_STRPN (Q04699) (277 aa) fasta scores: E(): 1.9e-37, 44.569% id in 267 aa, and to Bacillus halodurans maltose/maltodextrin ABC transporter permease BH2924 TR:Q9K8S9 (EMBL:AP001517) (280 aa) fasta scores: E(): 3.6e-76, 72.857% id in 280 aa; sugar ABC transporter permease 242551 2860230 SAR0208 Staphylococcus aureus subsp. aureus MRSA252 sugar ABC transporter permease YP_039673.1 241712 D 282458 CDS YP_039674.1 49482450 2860231 242725..243804 1 NC_002952.2 Similar to an internal region of Zymomonas mobilis glucose--fructose oxidoreductase Gfo SW:GFO_ZYMMO (Q07982) (439 aa) fasta scores: E(): 5.2e-17, 28.652% id in 356 aa. Full CDS is similar to Listeria monocytogenes NADH-dependent dehydrogenase homologue LapC TR:O52495 (EMBL:AF039207) (358 aa) fasta scores: E(): 7.8e-100, 67.507% id in 357 aa; oxidoreductase 243804 2860231 SAR0209 Staphylococcus aureus subsp. aureus MRSA252 oxidoreductase YP_039674.1 242725 D 282458 CDS YP_039675.1 49482451 2860232 243829..244869 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2165 TR:Q9KAX1 (EMBL:AP001514) (348 aa) fasta scores: E(): 2.1e-51, 41.040% id in 346 aa, and to Listeria monocytogenes NADH-dependent dehydrogenase homologue LapC TR:O52495 (EMBL:AF039207) (358 aa) fasta scores: E(): 1.2e-38, 38.873% id in 355 aa; oxidoreductase 244869 2860232 SAR0210 Staphylococcus aureus subsp. aureus MRSA252 oxidoreductase YP_039675.1 243829 D 282458 CDS YP_039676.1 49482452 2860233 244924..245892 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1249 TR:Q9KDG4 (EMBL:AP001511) (322 aa) fasta scores: E(): 1.2e-81, 58.385% id in 322 aa, and to Bacillus subtilis hypothetical protein YfiH SW:YFIH_BACSU (P54724) (313 aa) fasta scores: E(): 1.7e-36, 39.130% id in 299 aa; hypothetical protein 245892 2860233 SAR0211 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039676.1 244924 D 282458 CDS YP_039677.1 49482453 2860234 complement(246251..246745) 1 NC_002952.2 Similar to Pasteurella multocida hypothetical protein PM0984 TR:Q9CM58 (EMBL:AE006137) (172 aa) fasta scores: E(): 2.3e-24, 51.515% id in 165 aa, and to Haemophilus influenzae hypothetical protein HI0318 SW:Y318_HAEIN (P43984) (172 aa) fasta scores: E(): 4.1e-24, 52.381% id in 168 aa; hypothetical protein 246745 2860234 SAR0212 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039677.1 246251 R 282458 CDS YP_039678.1 49482454 2860412 246978..248357 1 NC_002952.2 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 248357 uhpT 2860412 uhpT Staphylococcus aureus subsp. aureus MRSA252 sugar phosphate antiporter YP_039678.1 246978 D 282458 CDS YP_039679.1 49482455 2860235 complement(248716..249474) 1 NC_002952.2 Probable two-component regulatory system family, response regulator protein. Similar to Streptococcus pyogenes two-component response regulator SPY1062 TR:Q99ZU9 (EMBL:AE006550) (262 aa) fasta scores: E(): 1.2e-21, 34.568% id in 243 aa, and to Bacillus halodurans two-component response regulator BH3679 TR:Q9K6P9 (EMBL:AP001519) (257 aa) fasta scores: E(): 3.6e-13, 28.346% id in 254 aa; response regulator 249474 2860235 SAR0214 Staphylococcus aureus subsp. aureus MRSA252 response regulator YP_039679.1 248716 R 282458 CDS YP_039680.1 49482456 2860539 complement(249467..251023) 1 NC_002952.2 Probable two-component regulatory system family, sensor kinase. No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Streptococcus pyogenes two-component sensor histidine kinase SPY1061 TR:Q99ZV0 (EMBL:AE006550) (549 aa) fasta scores: E(): 2.2e-15, 25.978% id in 358 aa, and Bacillus halodurans two-component sensor histidine kinase BH3678 TR:Q9K6Q0 (EMBL:AP001519) (605 aa) fasta scores: E(): 4.2e-13, 25.915% id in 328 aa; sensor kinase 251023 2860539 SAR0215 Staphylococcus aureus subsp. aureus MRSA252 sensor kinase YP_039680.1 249467 R 282458 CDS YP_039681.1 49482457 2860540 complement(251020..251988) 1 NC_002952.2 Similar to Treponema hyodysenteriae periplasmic-iron-binding protein BitA TR:Q9Z4R9 (EMBL:U75349) (336 aa) fasta scores: E(): 7.2e-24, 29.897% id in 291 aa, and to Streptococcus pyogenes periplasmic-iron-binding protein SPY1063 TR:Q99ZU8 (EMBL:AE006550) (323 aa) fasta scores: E(): 1.2e-20, 26.885% id in 305 aa; lipoprotein 251988 2860540 SAR0216 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039681.1 251020 R 282458 CDS YP_039682.1 49482458 2860035 252576..254825 1 NC_002952.2 Similar to Escherichia coli formate acetyltransferase 1 PflB SW:PFLB_ECOLI (P09373) (759 aa) fasta scores: E(): 1.4e-204, 66.227% id in 758 aa, and to Clostridium pasteurianum formate acetyltransferase Pfl SW:PFL_CLOPA (Q46266) (740 aa) fasta scores: E(): 3.5e-196, 65.041% id in 738 aa; formate acetyltransferase 254825 2860035 SAR0217 Staphylococcus aureus subsp. aureus MRSA252 formate acetyltransferase YP_039682.1 252576 D 282458 CDS YP_039683.1 49482459 2860627 254848..255603 1 NC_002952.2 Similar to Streptococcus mutans pyruvate formate-lyase activating enzyme Act SW:PFLA_STRMU (O68575) (263 aa) fasta scores: E(): 5.3e-45, 50.000% id in 240 aa, and to Listeria monocytogenes pyruvate-formate lyase activating enzyme PflC TR:Q9X767 (EMBL:AJ009627) (248 aa) fasta scores: E(): 6.9e-51, 53.814% id in 236 aa; pyruvate formate-lyase activating enzyme 255603 2860627 SAR0218 Staphylococcus aureus subsp. aureus MRSA252 pyruvate formate-lyase activating enzyme YP_039683.1 254848 D 282458 CDS YP_039684.1 49482460 2860628 255707..255874 1 NC_002952.2 hypothetical protein 255874 2860628 SAR0219 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039684.1 255707 D 282458 CDS YP_039685.1 49482461 2860629 255925..257688 1 NC_002952.2 Similar to Streptococcus pyogenes glycerophosphodiester phosphodiesterase SPY0839 TR:Q9A0C2 (EMBL:AE006534) (577 aa) fasta scores: E(): 1.2e-39, 35.233% id in 579 aa, and to Lactococcus lactis hypothetical protein YuhH TR:Q9CE50 (EMBL:AE006429) (617 aa) fasta scores: E(): 5.4e-37, 27.005% id in 611 aa; hypothetical protein 257688 2860629 SAR0220 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039685.1 255925 D 282458 CDS YP_039686.1 49482462 2860630 complement(257852..258196) 1 NC_002952.2 hypothetical protein 258196 2860630 SAR0221 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039686.1 257852 R 282458 CDS YP_039687.1 49482463 2860631 258386..260215 1 NC_002952.2 Similar to Staphylococcus aureus staphylocoagulase precursor SW:STC1_STAAU (P07767) (658 aa) fasta scores: E(): 2.3e-144, 73.520% id in 608 aa, and to Staphylococcus aureus staphylocoagulase precursor SW:STC2_STAAU (P17855) (715 aa) fasta scores: E(): 2.3e-141, 72.250% id in 609 aa. Contains a C-terminal imperfect repeat (ARPTQNKPSETNAYNVTTHANGQVSYG x4). CDS contains less amino acid residues at the C-terminus in comparison to other orthologues; staphylocoagulase precursor 260215 2860631 SAR0222 Staphylococcus aureus subsp. aureus MRSA252 staphylocoagulase precursor YP_039687.1 258386 D 282458 CDS YP_039688.1 49482464 2859623 complement(260802..261986) 1 NC_002952.2 Similar to Brassica napus glyoxysomal beta-ketoacyl-thiolase TR:Q43742 (EMBL:X93015) (462 aa) fasta scores: E(): 2.8e-56, 46.173% id in 392 aa. Previously sequenced as Staphylococcus aureus 3-ketoacyl-CoA transferase FadA TR:AAK51158 (EMBL:AY033081) (397 aa) fasta scores: E(): 4.6e-142, 99.239% id in 394 aa; thiolase 261986 fadA 2859623 fadA Staphylococcus aureus subsp. aureus MRSA252 thiolase YP_039688.1 260802 R 282458 CDS YP_039689.1 49482465 2859624 complement(262016..264277) 1 NC_002952.2 N-terminal region is similar to Mus musculus short chain 3-hydroxyacyl-CoA dehydrogenase precursor HadH SW:HCDH_MOUSE (Q61425) (314 aa) fasta scores: E(): 3e-21, 33.333% id in 294 aa. Previously sequenced as Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase FadB TR:AAK51157 (EMBL:AY033081) (753 aa) fasta scores: E(): 0, 98.672% id in 753 aa; fatty oxidation complex protein 264277 fadB 2859624 fadB Staphylococcus aureus subsp. aureus MRSA252 fatty oxidation complex protein YP_039689.1 262016 R 282458 CDS YP_039690.1 49482466 2859625 complement(264464..265675) 1 NC_002952.2 Similar to Mus musculus mitochondrial glutaryl-CoA dehydrogenase GcdH SW:GCDH_MOUSE (Q60759) (438 aa) fasta scores: E(): 1e-29, 32.659% id in 346 aa. Previously sequenced as Staphylococcus aureus acyl-CoA dehydrogenase FadD TR:AAK51156 (EMBL:AY033081) (418 aa) fasta scores: E(): 1e-154, 100.000% id in 403 aa; acyl-CoA dehydrogenase 265675 fadD 2859625 fadD Staphylococcus aureus subsp. aureus MRSA252 acyl-CoA dehydrogenase YP_039690.1 264464 R 282458 CDS YP_039691.1 49482467 2859626 complement(265787..267292) 1 NC_002952.2 Similar to Rhizobium leguminosarum malonyl CoA synthetase MatB TR:Q9ZIP5 (EMBL:AF117694) (504 aa) fasta scores: E(): 3.1e-38, 27.866% id in 506 aa. Previously sequenced as Staphylococcus aureus acyl-CoA synthetase FadE TR:AAK51155 (EMBL:AY033081) (501 aa) fasta scores: E(): 8.5e-198, 99.401% id in 501 aa; acyl-CoA synthetase 267292 fadE 2859626 fadE Staphylococcus aureus subsp. aureus MRSA252 acyl-CoA synthetase YP_039691.1 265787 R 282458 CDS YP_039692.1 49482468 2860658 complement(267318..268880) 1 NC_002952.2 Weakly similar to Homo sapiens mitochondrial succinyl-CoA:3-ketoacid-coenzyme A transferase SCOT SW:SCOT_HUMAN (P55809) (520 aa) fasta scores: E(): 2e-05, 21.681% id in 452 aa. Previously sequenced as Staphylococcus aureus acetyl-CoA/acetoacetyl-CoA transferase FadX TR:AAK51154 (EMBL:AY033081) (525 aa) fasta scores: E(): 2.2e-208, 98.654% id in 520 aa; acetyl-CoA transferase 268880 fadX 2860658 fadX Staphylococcus aureus subsp. aureus MRSA252 acetyl-CoA transferase YP_039692.1 267318 R 282458 CDS YP_039693.1 49482469 2860632 269254..269925 1 NC_002952.2 Similar to Synechocystis sp hypothetical protein SLR0541 TR:Q55488 (EMBL:D64006) (236 aa) fasta scores: E(): 6.7e-21, 34.615% id in 208 aa, and to Pseudomonas aeruginosa probable glutamine amidotransferase PA0531 TR:Q9I605 (EMBL:AE004489) (238 aa) fasta scores: E(): 1.7e-20, 33.476% id in 233 aa; glutamine amidotransferase 269925 2860632 SAR0228 Staphylococcus aureus subsp. aureus MRSA252 glutamine amidotransferase YP_039693.1 269254 D 282458 CDS YP_039694.1 49482470 2860633 270148..271290 1 NC_002952.2 No significant database matches to the full length CDS. C-terminal region is similar to similar to Pyrococcus abyssi hypothetical protein PAB0037 TR:Q9V2K2 (EMBL:AJ248283) (249 aa) fasta scores: E(): 5.7e-07, 28.384% id in 229 aa, and to Streptococcus pyogenes hypothetical protein SPY1366 TR:Q99Z72 (EMBL:AE006574) (269 aa) fasta scores: E(): 0.0023, 23.675% id in 283 aa. Possible alternative translational start sites; hypothetical protein 271290 2860633 SAR0229 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039694.1 270148 D 282458 CDS YP_039695.1 49482471 2860634 complement(271601..273076) 1 NC_002952.2 Similar to Bacillus halodurans nickel ABC transporter BH1796 TR:Q9KBX8 (EMBL:AP001513) (528 aa) fasta scores: E(): 4.7e-23, 31.653% id in 496 aa, and to Agrobacterium radiobacter agropinic acid permease AgaA TR:O50260 (EMBL:AF242881) (509 aa) fasta scores: E(): 5.6e-16, 26.261% id in 476 aa; extracellular solute-binding lipoprotein 273076 2860634 SAR0230 Staphylococcus aureus subsp. aureus MRSA252 extracellular solute-binding lipoprotein YP_039695.1 271601 R 282458 CDS YP_039696.1 49482472 2860635 complement(273274..273630) 1 NC_002952.2 Similar to Streptomyces coelicolor hypothetical protein SC2H2.18 TR:Q9F3D7 (EMBL:AL450289) (119 aa) fasta scores: E(): 1.5e-16, 42.857% id in 119 aa, and to Rhizobium loti hypothetical protein MLL7394 TR:BAB53507 (EMBL:AP003011) (120 aa) fasta scores: E(): 1.5e-16, 48.305% id in 118 aa; hypothetical protein 273630 2860635 SAR0231 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039696.1 273274 R 282458 CDS YP_039697.1 49482473 2860636 complement(273787..273960) 1 NC_002952.2 hypothetical protein 273960 2860636 SAR0232 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039697.1 273787 R 282458 CDS YP_039698.1 49482474 2860637 complement(273985..275130) 1 NC_002952.2 Similar to Bacillus subtilis flavohemoprotein Hmp SW:HMPA_BACSU (P49852) (399 aa) fasta scores: E(): 7.5e-41, 38.653% id in 401 aa, and to Vibrio parahaemolyticus flavohemoprotein Hmp SW:HMPA_VIBPA (P40609) (394 aa) fasta scores: E(): 2.3e-35, 34.596% id in 396 aa; flavohemoprotein 275130 2860637 SAR0233 Staphylococcus aureus subsp. aureus MRSA252 flavohemoprotein YP_039698.1 273985 R 282458 CDS YP_039699.1 49482475 2859695 275703..276656 1 NC_002952.2 Similar to Bacillus subtilis L-lactate dehydrogenase Ldh SW:LDH_BACSU (P13714) (320 aa) fasta scores: E(): 1.5e-73, 64.630% id in 311 aa, and to Bacillus stearothermophilus L-lactate dehydrogenase Ldh TR:Q9S0N0 (EMBL:AB033627) (317 aa) fasta scores: E(): 1.4e-77, 67.101% id in 307 aa. Similar to SAR2680, 59.223% identity (59.609% ungapped) in 309 aa overlap; L-lactate dehydrogenase 276656 ldh1 2859695 ldh1 Staphylococcus aureus subsp. aureus MRSA252 L-lactate dehydrogenase YP_039699.1 275703 D 282458 CDS YP_039700.1 49482476 2860638 complement(276977..278506) 1 NC_002952.2 Similar to the N-terminal region of Bacillus subtilis PTS system, glucose-specific IIABC component PtsG SW:PTGA_BACSU (P20166) (699 aa) fasta scores: E(): 6.6e-88, 47.500% id in 520 aa. Full length CDS is similar to Borrelia burgdorferi PTS system, glucose-specific IIBC component BB0645 TR:O51590 (EMBL:AE001166) (514 aa) fasta scores: E(): 6.5e-124, 61.961% id in 510 aa; PTS transport system, IIBC component 278506 2860638 SAR0235 Staphylococcus aureus subsp. aureus MRSA252 PTS transport system, IIBC component YP_039700.1 276977 R 282458 CDS YP_039701.1 49482477 2860639 278870..279805 1 NC_002952.2 Similar to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SW:IUNH_CRIFA (Q27546) (314 aa) fasta scores: E(): 4.5e-38, 37.954% id in 303 aa, and to Escherichia coli hypothetical protein YbeK SW:YBEK_ECOLI (P41409) (311 aa) fasta scores: E(): 1.7e-45, 45.367% id in 313 aa; inosine-uridine preferring nucleoside hydrolase 279805 2860639 SAR0236 Staphylococcus aureus subsp. aureus MRSA252 inosine-uridine preferring nucleoside hydrolase YP_039701.1 278870 D 282458 CDS YP_039702.1 49482478 2860640 279841..279987 1 NC_002952.2 hypothetical protein 279987 2860640 SAR0237 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039702.1 279841 D 282458 CDS YP_039703.1 49482479 2860642 282224..282691 1 NC_002952.2 Similar to Escherichia coli PTS system, galactitol-specific IIA component GatA SW:PTKA_ECOLI (P37187) (150 aa) fasta scores: E(): 3.9e-05, 28.986% id in 138 aa, and to Bacillus halodurans phosphotransferase system FruA TR:Q9Z9U3 (EMBL:AB011837) (160 aa) fasta scores: E(): 1.9e-17, 43.421% id in 152 aa; PTS transport system, IIA component 282691 2860642 SAR0240 Staphylococcus aureus subsp. aureus MRSA252 PTS transport system, IIA component YP_039703.1 282224 D 282458 CDS YP_039704.1 49482480 2860643 282714..282992 1 NC_002952.2 Similar to Escherichia coli PTS system, galactitol-specific IIB component GatB SW:PTKB_ECOLI (P37188) (94 aa) fasta scores: E(): 3.7e-09, 37.363% id in 91 aa, and to Bacillus halodurans PTS system, galactitol-specific enzyme IIB component GatB TR:Q9KGB5 (EMBL:AP001507) (94 aa) fasta scores: E(): 1.5e-24, 81.319% id in 91 aa; PTS transport system, IIB component 282992 2860643 SAR0241 Staphylococcus aureus subsp. aureus MRSA252 PTS transport system, IIB component YP_039704.1 282714 D 282458 CDS YP_039705.1 49482481 2860644 283219..284478 1 NC_002952.2 Similar to Escherichia coli PTS system, galactitol-specific IIC component GatC SW:PTKC_ECOLI (P37189) (451 aa) fasta scores: E(): 5.1e-68, 44.337% id in 415 aa, and to Bacillus halodurans PTS system galactitol-specific enzyme IIC component GatC TR:Q9Z9U2 (EMBL:AB011837) (419 aa) fasta scores: E(): 4.6e-121, 78.043% id in 419 aa; PTS transport system, IIC component 284478 2860644 SAR0242 Staphylococcus aureus subsp. aureus MRSA252 PTS transport system, IIC component YP_039705.1 283219 D 282458 CDS YP_039706.1 49482482 2860645 284496..285551 1 NC_002952.2 Similar to Bacillus subtilis sorbitol dehydrogenase GutB SW:DHSO_BACSU (Q06004) (352 aa) fasta scores: E(): 2.9e-30, 35.077% id in 325 aa, and to Bacillus halodurans sorbitol dehydrogenase GutB SW:DHSO_BACHD (Q9Z9U1) (343 aa) fasta scores: E(): 1.6e-83, 62.974% id in 343 aa; zinc-binding dehydrogenase 285551 2860645 SAR0243 Staphylococcus aureus subsp. aureus MRSA252 zinc-binding dehydrogenase YP_039706.1 284496 D 282458 CDS YP_039707.1 49482483 2860646 285553..285699 1 NC_002952.2 Poor database matches. Similar to the C-terminal region of Bacillus halodurans hypothetical protein TR:Q9Z9U0 (EMBL:AB011837) (100 aa) fasta scores: E(): 5e-05, 47.727% id in 44 aa; hypothetical protein 285699 2860646 SAR0244 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039707.1 285553 D 282458 CDS YP_039708.1 49482484 2860647 285723..286766 1 NC_002952.2 Similar to Escherichia coli galactitol-1-phosphate 5-dehydrogenase GatD SW:GATD_ECOLI (P37190) (346 aa) fasta scores: E(): 3.7e-37, 36.452% id in 310 aa, and to Bacillus halodurans sorbitol dehydrogenase GutB TR:Q9KGB7 (EMBL:AP001507) (354 aa) fasta scores: E(): 4.1e-78, 56.936% id in 346 aa; zinc-binding dehydrogenase 286766 2860647 SAR0245 Staphylococcus aureus subsp. aureus MRSA252 zinc-binding dehydrogenase YP_039708.1 285723 D 282458 CDS YP_039709.1 49482485 2860648 287294..288010 1 NC_002952.2 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 288010 ispD 2860648 ispD Staphylococcus aureus subsp. aureus MRSA252 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_039709.1 287294 D 282458 CDS YP_039710.1 49482486 2860649 288003..289028 1 NC_002952.2 Similar to Escherichia coli L-idonate 5-dehydrogenase IdnD SW:IDND_ECOLI (P39346) (343 aa) fasta scores: E(): 4.8e-05, 25.000% id in 308 aa, and to Thermoplasma volcanium alcohol dehydrogenase TVG0995648 TR:BAB60114 (EMBL:AP000994) (335 aa) fasta scores: E(): 1.2e-07, 25.581% id in 344 aa. Similar to SAR0253, 80.645% identity (80.645% ungapped) in 341 aa overlap; zinc-binding dehydrogenase 289028 2860649 SAR0247 Staphylococcus aureus subsp. aureus MRSA252 zinc-binding dehydrogenase YP_039710.1 288003 D 282458 CDS YP_039711.1 49482487 2860650 289050..290744 1 NC_002952.2 No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Staphylococcus epidermidis CDP-glycerol:poly(glycerolphosphate) glycerophosphotransferase TagF TR:Q9RPD1 (EMBL:AF162863) (721 aa) fasta scores: E(): 1.2e-21, 26.873% id in 387 aa, and Haemophilus influenzae hypothetical protein TR:Q48156 (EMBL:Z37516) (789 aa) fasta scores: E(): 2e-33, 30.900% id in 411 aa. Similar to SAR0254, 79.211% identity (79.211% ungapped) in 558 aa overlap; hypothetical protein 290744 2860650 SAR0248 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039711.1 289050 D 282458 CDS YP_039712.1 49482488 2860651 complement(291010..291171) 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 291171 2860651 SAR0249 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039712.1 291010 R 282458 CDS YP_039713.1 49482489 2860652 291336..291461 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 291461 2860652 SAR0250 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039713.1 291336 D 282458 CDS YP_039714.1 49482490 2860653 291714..292883 1 NC_002952.2 Similar to the C-terminal regions of Bacillus subtilis teichoic acid biosynthesis protein F TagF SW:TAGF_BACSU (P13485) (746 aa) fasta scores: E(): 5.6e-77, 48.139% id in 403 aa, and to Staphylococcus epidermidis CDP-glycerol:poly(glycerolphosphate) glycerophosphotransferase TagF TR:Q9RPD1 (EMBL:AF162863) (721 aa) fasta scores: E(): 7e-72, 46.650% id in 403 aa; teichoic acid biosynthesis protein 292883 2860653 SAR0251 Staphylococcus aureus subsp. aureus MRSA252 teichoic acid biosynthesis protein YP_039714.1 291714 D 282458 CDS YP_039715.1 49482491 2860654 293159..293875 1 NC_002952.2 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 293875 ispD 2860654 ispD Staphylococcus aureus subsp. aureus MRSA252 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_039715.1 293159 D 282458 CDS YP_039716.1 49482492 2860655 293868..294893 1 NC_002952.2 Similar to Escherichia coli L-idonate 5-dehydrogenase IdnD SW:IDND_ECOLI (P39346) (343 aa) fasta scores: E(): 6.7e-06, 23.006% id in 326 aa, and to Candida sp HA167 xylitol dehydrogenase Xdh TR:O74230 (EMBL:AF072541) (353 aa) fasta scores: E(): 5.1e-06, 24.425% id in 348 aa. Similar to SAR0247, 80.645% identity (80.645% ungapped) in 341 aa overlap; zinc-binding dehydrogenase 294893 2860655 SAR0253 Staphylococcus aureus subsp. aureus MRSA252 zinc-binding dehydrogenase YP_039716.1 293868 D 282458 CDS YP_039717.1 49482493 2860995 294915..296603 1 NC_002952.2 C-terminus is similar to Staphylococcus epidermidis epidermidis CDP-glycerol:poly(glycerolphosphate) glycerophosphotransferase TagF TR:Q9RPD1 (EMBL:AF162863) (721 aa) fasta scores: E(): 6.3e-19, 24.067% id in 536 aa. Full length CDS is similar to Haemophilus influenzae hypothetical protein TR:Q48156 (EMBL:Z37516) (789 aa) fasta scores: E(): 2.7e-32, 27.563% id in 595 aa. Similar to SAR0248, 79.211% identity (79.211% ungapped) in 558 aa overlap; hypothetical protein 296603 2860995 SAR0254 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039717.1 294915 D 282458 CDS YP_039718.1 49482494 2861468 296636..298360 1 NC_002952.2 No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Streptococcus thermophilus exopolysaccharide biosynthesis protein EpsI TR:Q56046 (EMBL:U40830) (324 aa) fasta scores: E(): 1e-11, 31.522% id in 276 aa, and Lactobacillus delbrueckii glycosyltransferase EpsJ TR:Q9F0B8 (EMBL:AF267127) (327 aa) fasta scores: E(): 6.7e-13, 29.851% id in 268 aa; glycosyl transferase family protein 298360 2861468 SAR0255 Staphylococcus aureus subsp. aureus MRSA252 glycosyl transferase family protein YP_039718.1 296636 D 282458 CDS YP_039719.1 49482495 2859125 298500..299174 1 NC_002952.2 involved in peptidoglycan cross-linking; cell wall biosynthesis protein ScdA 299174 scdA 2859125 scdA Staphylococcus aureus subsp. aureus MRSA252 cell wall biosynthesis protein ScdA YP_039719.1 298500 D 282458 CDS YP_039720.1 49482496 2859063 299425..301179 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Previously sequenced as Staphylococcus aureus autolysin sensor kinase LytS TR:Q53705 (EMBL:L42945) (584 aa) fasta scores: E(): 3.6e-213, 98.288% id in 584 aa. Similar to Bacillus subtilis autolysin sensor kinase lytS TR:P94513 (EMBL:Z75208) (593 aa) fasta scores: E(): 1.7e-102, 46.918% id in 584 aa; autolysin sensor kinase 301179 lytS 2859063 lytS Staphylococcus aureus subsp. aureus MRSA252 autolysin sensor kinase YP_039720.1 299425 D 282458 CDS YP_039721.1 49482497 2859818 301182..301922 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Previously sequenced as Staphylococcus aureus autolysin response regulator LytR TR:P96456 (EMBL:L42945) (246 aa) fasta scores: E(): 9.6e-90, 98.780% id in 246 aa. Similar to Bacillus subtilis autolysin response regulator LytT TR:P94514 (EMBL:Z75208) (241 aa) fasta scores: E(): 4.4e-34, 40.664% id in 241 aa; two-component response regulator 301922 lytR 2859818 lytR Staphylococcus aureus subsp. aureus MRSA252 two-component response regulator YP_039721.1 301182 D 282458 CDS YP_039722.1 49482498 2859808 302035..302478 1 NC_002952.2 negatively regulates murein hydrolase activity; murein hydrolase regulator LrgA 302478 lrgA 2859808 lrgA Staphylococcus aureus subsp. aureus MRSA252 murein hydrolase regulator LrgA YP_039722.1 302035 D 282458 CDS YP_039723.1 49482499 2859809 302471..303172 1 NC_002952.2 in conjunction with LrgA this protein inhibits the expression or activity of extracellular murein hydrolases; antiholin-like protein LrgB 303172 lrgB 2859809 lrgB Staphylococcus aureus subsp. aureus MRSA252 antiholin-like protein LrgB YP_039723.1 302471 D 282458 CDS YP_039724.1 49482500 2860271 303513..305804 1 NC_002952.2 C-terminal region is similar to Pseudomonas aeruginosa nitric-oxide reductase subunit B NorB SW:NORB_PSEAE (Q59647) (466 aa) fasta scores: E(): 6e-24, 29.400% id in 483 aa. Full length CDS is similar to Alcaligenes eutrophus nitric oxide reductase TR:O30368 (EMBL:AF002217) (762 aa) fasta scores: E(): 1e-96, 35.894% id in 755 aa.; nitric oxide reductase 305804 2860271 SAR0261 Staphylococcus aureus subsp. aureus MRSA252 nitric oxide reductase YP_039724.1 303513 D 282458 CDS YP_039725.1 49482501 2860272 complement(306030..306734) 1 NC_002952.2 Similar to Escherichia coli fatty acyl responsive regulator FarR SW:FARR_ECOLI (P13669) (240 aa) fasta scores: E(): 5.7e-11, 25.424% id in 236 aa, and to Bacillus subtilis hypothetical protein YydK TR:Q45591 (EMBL:D78193) (238 aa) fasta scores: E(): 7.3e-32, 40.870% id in 230 aa; GntR family transcriptional regulator 306734 2860272 SAR0262 Staphylococcus aureus subsp. aureus MRSA252 GntR family transcriptional regulator YP_039725.1 306030 R 282458 CDS YP_039726.1 49482502 2860273 306881..307672 1 NC_002952.2 Poor database matches to the full length CDS. Similar to the C-terminal regions of Staphylococcus carnosus PTS system, glucose-specific IIABC component GlcA TR:Q57071 (EMBL:X93360) (675 aa) fasta scores: E(): 1.1e-21, 33.065% id in 248 aa, and to Bacillus subtilis PTS system IIABC component YbfS SW:YBFS_BACSU (P39816) (631 aa) fasta scores: E(): 6.3e-18, 31.276% id in 243 aa; PTS transporter 307672 2860273 SAR0263 Staphylococcus aureus subsp. aureus MRSA252 PTS transporter YP_039726.1 306881 D 282458 CDS YP_039727.1 49482503 2858969 307688..309124 1 NC_002952.2 Similar to Bacillus subtilis 6-phospho-beta-glucosidase BglA SW:BGLA_BACSU (P42973) (479 aa) fasta scores: E(): 1.3e-145, 70.146% id in 479 aa, and to Escherichia coli 6-phospho-beta-glucosidase BglA SW:BGLA_ECOLI (Q46829) (479 aa) fasta scores: E(): 1.6e-122, 60.714% id in 476 aa; 6-phospho-beta-glucosidase 309124 bglA 2858969 bglA Staphylococcus aureus subsp. aureus MRSA252 6-phospho-beta-glucosidase YP_039727.1 307688 D 282458 CDS YP_039728.1 49482504 2860274 complement(309619..310380) 1 NC_002952.2 Similar to Haemophilus influenzae hypothetical protein HI0095 SW:Y095_HAEIN (Q57060) (251 aa) fasta scores: E(): 6e-57, 58.333% id in 252 aa, and to Pasteurella multocida hypothetical protein PM1158 TR:Q9CLQ7 (EMBL:AE006156) (251 aa) fasta scores: E(): 4.3e-55, 57.540% id in 252 aa; hypothetical protein 310380 2860274 SAR0265 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039728.1 309619 R 282458 CDS YP_039729.1 49482505 2860275 complement(310631..311545) 1 NC_002952.2 Similar to Escherichia coli ribokinase RbsK SW:RBSK_ECOLI (P05054) (309 aa) fasta scores: E(): 9.4e-39, 40.604% id in 298 aa, and to Lactobacillus bavaricus ribokinase RbsK rbsK TR:Q9X4M5 (EMBL:AF115391) (302 aa) fasta scores: E(): 2.7e-56, 54.181% id in 299 aa; ribokinase 311545 2860275 SAR0266 Staphylococcus aureus subsp. aureus MRSA252 ribokinase YP_039729.1 310631 R 282458 CDS YP_039730.1 49482506 2860276 complement(311573..311977) 1 NC_002952.2 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 311977 2860276 SAR0267 Staphylococcus aureus subsp. aureus MRSA252 D-ribose pyranase YP_039730.1 311573 R 282458 CDS YP_039731.1 49482507 2860277 complement(311992..312873) 1 NC_002952.2 Similar to Staphylococcus xylosus glucose uptake protein GlcU TR:O07881 (EMBL:Y14043) (288 aa) fasta scores: E(): 1.6e-26, 34.256% id in 289 aa, and to Lactobacillus bavaricus ribose transporter RbsU TR:Q9X4M3 (EMBL:AF115391) (294 aa) fasta scores: E(): 2.6e-60, 55.442% id in 294 aa; sugar transport protein 312873 2860277 SAR0268 Staphylococcus aureus subsp. aureus MRSA252 sugar transport protein YP_039731.1 311992 R 282458 CDS YP_039732.1 49482508 2860278 complement(313105..314103) 1 NC_002952.2 Similar to Escherichia coli ribose operon repressor RbsR SW:RBSR_ECOLI (P25551) (329 aa) fasta scores: E(): 8.6e-27, 29.697% id in 330 aa, and to Lactobacillus bavaricus rbs operon repressor RbsR TR:Q9X4M6 (EMBL:AF115391) (335 aa) fasta scores: E(): 2.3e-39, 39.228% id in 311 aa; LacI family regulatory protein 314103 2860278 SAR0269 Staphylococcus aureus subsp. aureus MRSA252 LacI family regulatory protein YP_039732.1 313105 R 282458 CDS YP_039733.1 49482509 2860279 314320..314433 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 314433 2860279 SAR0269a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039733.1 314320 D 282458 CDS YP_039734.1 49482510 2860280 314483..314875 1 NC_002952.2 hypothetical protein 314875 2860280 SAR0270 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039734.1 314483 D 282458 CDS YP_039735.1 49482511 2860281 complement(315004..316380) 1 NC_002952.2 Similar to Streptomyces lavendulae mitomycin export system protein Mct TR:Q9WVV3 (EMBL:AF127374) (484 aa) fasta scores: E(): 6e-22, 25.114% id in 438 aa, and to Pseudomonas aeruginosa probable MFS transporter PA2055 TR:Q9I260 (EMBL:AE004632) (471 aa) fasta scores: E(): 3.4e-24, 28.019% id in 414 aa; transport protein 316380 2860281 SAR0271 Staphylococcus aureus subsp. aureus MRSA252 transport protein YP_039735.1 315004 R 282458 CDS YP_039736.1 49482512 2860282 316614..317606 1 NC_002952.2 Similar to Bacillus sphaericus penicillin acylase SW:PAC_BACSH (P12256) (338 aa) fasta scores: E(): 8.1e-35, 29.483% id in 329 aa, and to Bacillus subtilis hypothetical protein YxeI SW:YXEI_BACSU (P54948) (328 aa) fasta scores: E(): 1.6e-35, 32.622% id in 328 aa; choloylglycine hydrolase 317606 2860282 SAR0272 Staphylococcus aureus subsp. aureus MRSA252 choloylglycine hydrolase YP_039736.1 316614 D 282458 CDS YP_039737.1 49482513 2859816 317932..318882 1 NC_002952.2 Previously sequenced as Staphylococcus aureus peptidoglycan hydrolase LytM TR:O33599 (EMBL:L77194) (322 aa) fasta scores: E(): 3.4e-113, 98.418% id in 316 aa. C-terminus is similar to an internal region of Staphylococcus staphylolyticus lysostaphin precursor Lss SW:LSTP_STAST (P10548) (480 aa) fasta scores: E(): 4.8e-19, 48.905% id in 137 aa; peptidoglycan hydrolase 318882 lytM 2859816 lytM Staphylococcus aureus subsp. aureus MRSA252 peptidoglycan hydrolase YP_039737.1 317932 D 282458 CDS YP_039738.1 49482514 2860283 complement(318934..319593) 1 NC_002952.2 Similar to the N-terminal regions of Streptococcus pyogenes ABC transporter SPY0744 TR:Q9A0K0 (EMBL:AE006526) (307 aa) fasta scores: E(): 4.9e-17, 38.278% id in 209 aa, and Bacillus halodurans hypothetical protein YfiL TR:Q9RC44 (EMBL:AB024563) (310 aa) fasta scores: E(): 1.7e-16, 36.408% id in 206 aa; ABC transporter ATP-binding protein 319593 2860283 SAR0274 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_039738.1 318934 R 282458 CDS YP_039739.1 49482515 2860284 complement(319607..320527) 1 NC_002952.2 Poor database matches. Similar to N-terminal regions of Streptococcus pyogenes ABC transporter SPY0746 TR:Q9A0J8 (EMBL:AE006526) (372 aa) fasta scores: E(): 0.0045, 24.542% id in 273 aa, and Pyrococcus horikoshii hypothetical protein PH1531 TR:O59200 (EMBL:AP000006) (420 aa) fasta scores: E(): 0.058, 21.683% id in 309 aa; hypothetical protein 320527 2860284 SAR0275 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039739.1 319607 R 282458 CDS YP_039740.1 49482516 2860285 complement(320524..321690) 1 NC_002952.2 Poor database matches. C-terminus is similar to internal regions of Borrelia burgdorferi conserved hypothetical integral membrane protein BB0584 TR:O51531 (EMBL:AE001160) (448 aa) fasta scores: E(): 0.48, 17.695% id in 243 aa, and to Buchnera aphidicola (subsp. Acyrthosiphon pisum) hypothetical transport protein BU466 SW:Y466_BUCAI (P57538) (390 aa) fasta scores: E(): 0.57, 22.778% id in 180 aa; hypothetical protein 321690 2860285 SAR0276 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039740.1 320524 R 282458 CDS YP_039741.1 49482517 2860286 complement(321758..323281) 1 NC_002952.2 Poor database matches. Similar to N-terminal region of Homo sapiens cylicin I CYLC1 or cyl1 or cyL SW:CYL1_HUMAN (P35663) (598 aa) fasta scores: E(): 6.7e-05, 25.462% id in 487 aa; hypothetical protein 323281 2860286 SAR0277 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039741.1 321758 R 282458 CDS YP_039742.1 49482518 2860287 complement(323611..324513) 1 NC_002952.2 Similar to Staphylococcus carnosus major secreted protein SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 4.1e-16, 32.932% id in 249 aa, and to Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 8e-17, 31.457% id in 302 aa. C-terminus is similar to SAR2388, 59.821% identity (62.037% ungapped) in 112 aa overlap; hypothetical protein 324513 2860287 SAR0278 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039742.1 323611 R 282458 CDS YP_039743.1 49482519 2860288 324752..325045 1 NC_002952.2 Similar to Clostridium acetobutylicum hypothetical protein SW:YHS1_CLOAB (P34159) (96 aa) fasta scores: E(): 2.6e-09, 40.625% id in 96 aa, and to Bacillus halodurans hypothetical protein BH0972 TR:Q9KE84 (EMBL:AP001510) (96 aa) fasta scores: E(): 0.00013, 30.526% id in 95 aa; hypothetical protein 325045 2860288 SAR0279 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039743.1 324752 D 282458 CDS YP_039744.1 49482520 2860289 325128..328157 1 NC_002952.2 Poor database matches. Internal region of the CDS is similar to an internal region of Entamoeba histolytica myosin heavy chain protein MhcA TR:Q07569 (EMBL:L03534) (2139 aa) fasta scores: E(): 0.00025, 21.216% id in 806 aa. Full length CDS is similar to Bacillus subtilis hypothetical protein YueB TR:O32101 (EMBL:Z99120) (1076 aa) fasta scores: E(): 2.8e-08, 20.631% id in 1110 aa; hypothetical protein 328157 2860289 SAR0280 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039744.1 325128 D 282458 CDS YP_039745.1 49482521 2860290 328157..328615 1 NC_002952.2 hypothetical protein 328615 2860290 SAR0281 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039745.1 328157 D 282458 CDS YP_039746.1 49482522 2860291 328587..328829 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YukD TR:P71071 (EMBL:Z82015) (79 aa) fasta scores: E(): 0.034, 26.923% id in 78 aa; hypothetical protein 328829 2860291 SAR0282 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039746.1 328587 D 282458 CDS YP_039747.1 49482523 2860292 328842..330176 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YukC TR:P71070 (EMBL:Z82015) (451 aa) fasta scores: E(): 2.6e-13, 24.088% id in 411 aa, and to Bacillus halodurans hypothetical protein BH0974 protein bh0974 TR:Q9KE82 (EMBL:AP001510) (440 aa) fasta scores: E(): 5.5e-12, 21.114% id in 431 aa. CDS contains C-terminal hydrophilic domain; hypothetical protein 330176 2860292 SAR0283 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039747.1 328842 D 282458 CDS YP_039748.1 49482524 2860293 330198..334646 1 NC_002952.2 Internal region is similar to Bacillus cereus diarrhoeal toxin BceT TR:P70871 (EMBL:D17312) (366 aa) fasta scores: E(): 2.1e-71, 57.746% id in 355 aa. C-terminal region is similar to Bacillus subtilis hypothetical protein YukA TR:P71068 (EMBL:Z99120) (1207 aa) fasta scores: E(): 2.1e-119, 38.767% id in 1233 aa; hypothetical protein 334646 2860293 SAR0284 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039748.1 330198 D 282458 CDS YP_039749.1 49482525 2860294 334649..334915 1 NC_002952.2 No database matches; hypothetical protein 334915 2860294 SAR0285 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039749.1 334649 D 282458 CDS YP_039750.1 49482526 2860295 334938..335333 1 NC_002952.2 Hydrophilic protein. No significant database matches; hypothetical protein 335333 2860295 SAR0286 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039750.1 334938 D 282458 CDS YP_039751.1 49482527 2860296 335355..337025 1 NC_002952.2 Poor database matches. C-terminal region is similar to the N-terminus of Streptococcus thermophilus bacteriophage Sfi11 minor tail protein TR:O80179 (EMBL:AF158600) (1510 aa) fasta scores: E(): 1.1, 20.200% id in 500 aa; hypothetical protein 337025 2860296 SAR0287 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039751.1 335355 D 282458 CDS YP_039752.1 49482528 2860297 337041..337685 1 NC_002952.2 No significant database matches to the full length CDS. Weakly similar to the N-terminal region of Thermoplasma volcanium hypothetical protein TVG0160586 TR:BAB59293 (EMBL:AP000991) (469 aa) fasta scores: E(): 0.76, 26.154% id in 195 aa; hypothetical protein 337685 2860297 SAR0288 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039752.1 337041 D 282458 CDS YP_039753.1 49482529 2860298 337685..338140 1 NC_002952.2 hypothetical protein 338140 2860298 SAR0289 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039753.1 337685 D 282458 CDS YP_039754.1 49482530 2860299 338160..338591 1 NC_002952.2 hypothetical protein 338591 2860299 SAR0290 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039754.1 338160 D 282458 CDS YP_039755.1 49482531 2860300 338615..339202 1 NC_002952.2 Poor database matches. Similar to internal regions of Archaeoglobus fulgidus quinone oxidoreductase subunit AF1831 TR:O28444 (EMBL:AE000976) (369 aa) fasta scores: E(): 1.3, 24.725% id in 182 aa, and to Enterococcus faecalis peptide antibiotic AS-48 maturation and biosynthesis protein AS-48B TR:O53024 (EMBL:Y12234) (563 aa) fasta scores: E(): 2.3, 26.738% id in 187 aa; hypothetical protein 339202 2860300 SAR0291 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039755.1 338615 D 282458 CDS YP_039756.1 49482532 2860301 339379..339597 1 NC_002952.2 hypothetical protein 339597 2860301 SAR0292 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039756.1 339379 D 282458 CDS YP_039757.1 49482533 2860926 339729..340229 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3703 TR:Q9K6M5 (EMBL:AP001519) (169 aa) fasta scores: E(): 7.3e-09, 28.659% id in 164 aa, and to C-terminal region of Bacillus subtilis hypothetical protein YeeF TR:O31506 (EMBL:Z99107) (827 aa) fasta scores: E(): 2.9e-10, 27.397% id in 146 aa. Similar to SAR0294, 66.061% identity (66.061% ungapped) in 165 aa overlap and to SAR0295, 72% identity in 157 aa overlap; hypothetical protein 340229 2860926 SAR0293 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039757.1 339729 D 282458 CDS YP_039758.1 49482534 2860927 340240..340740 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3703 TR:Q9K6M5 (EMBL:AP001519) (169 aa) fasta scores: E(): 3.2e-08, 28.834% id in 163 aa, and to C-terminal region of Bacillus subtilis YeeF hypothetical protein TR:O31506 (EMBL:Z99107) (827 aa) fasta scores: E(): 1e-12, 32.000% id in 150 aa. Similar to SAR0293, 66.061% identity (66.061% ungapped) in 165 aa overlap; hypothetical protein 340740 2860927 SAR0294 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039758.1 340240 D 282458 CDS YP_039759.1 49482535 2860930 342424..342750 1 NC_002952.2 No significant database matches. Truncated at the N-terminus in comparison to N315 and Mu50 orthologues. Possible pseudogene; hypothetical protein 342750 2860930 SAR0299 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039759.1 342424 D 282458 CDS YP_039760.1 49482536 2860931 342884..343282 1 NC_002952.2 hypothetical protein 343282 2860931 SAR0301 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039760.1 342884 D 282458 CDS YP_039761.1 49482537 2860932 complement(343532..344356) 1 NC_002952.2 Similar to Staphylococcus carnosus nitrite transporter NirC TR:Q9X2M6 (EMBL:AF029224) (276 aa) fasta scores: E(): 2.3e-42, 43.542% id in 271 aa, and to Bacillus subtilis hypothetical protein Ywcj SW:YWCJ_BACSU (P39608) (256 aa) fasta scores: E(): 6.7e-13, 28.571% id in 245 aa; formate/nitrite transporter 344356 2860932 SAR0302 Staphylococcus aureus subsp. aureus MRSA252 formate/nitrite transporter YP_039761.1 343532 R 282458 CDS YP_039762.1 49482538 2860933 complement(344607..345914) 1 NC_002952.2 Similar to Corynebacterium glutamicum branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_CORGL (O06754) (426 aa) fasta scores: E(): 1.3e-45, 38.642% id in 427 aa, and to Bacillus subtilis branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_BACSU (P94499) (440 aa) fasta scores: E(): 1.7e-55, 38.928% id in 429 aa; amino acid transport system 345914 2860933 SAR0303 Staphylococcus aureus subsp. aureus MRSA252 amino acid transport system YP_039762.1 344607 R 282458 CDS YP_039763.1 49482539 2860934 346498..347388 1 NC_002952.2 Similar to Haemophilus influenzae lipoprotein e precursor Hel SW:HEL_HAEIN (P26093) (274 aa) fasta scores: E(): 3e-24, 33.942% id in 274 aa, and to Streptococcus equisimilis cytoplasmic membrane lipoprotein precursor LppC TR:O05471 (EMBL:Y12602) (285 aa) fasta scores: E(): 2.4e-38, 43.448% id in 290 aa; hypothetical protein 347388 2860934 SAR0304 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039763.1 346498 D 282458 CDS YP_039764.1 49482540 2860935 347637..348686 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YxeA TR:Q9CDG5 (EMBL:AE006454) (357 aa) fasta scores: E(): 2.3e-47, 44.077% id in 363 aa, and to Deinococcus radiodurans hypothetical protein DRA0279 TR:Q9RYN1 (EMBL:AE001863) (353 aa) fasta scores: E(): 3.6e-29, 31.818% id in 352 aa; hypothetical protein 348686 2860935 SAR0305 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039764.1 347637 D 282458 CDS YP_039765.1 49482541 2860936 348699..349376 1 NC_002952.2 Similar to Escherichia coli lipoprotein releasing system ATP-binding protein LolD SW:LOLD_ECOLI (P75957) (233 aa) fasta scores: E(): 3.8e-22, 37.387% id in 222 aa, and to Lactococcus lactis ABC transporter ATP-binding protein YxeB TR:Q9CDG4 (EMBL:AE006454) (223 aa) fasta scores: E(): 5.5e-38, 58.525% id in 217 aa; ABC transporter ATP-binding protein 349376 2860936 SAR0306 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_039765.1 348699 D 282458 CDS YP_039766.1 49482542 2860937 349584..350615 1 NC_002952.2 Similar to Bacillus amyloliquefaciens PTS system, fructose-specific IIBC component FruA SW:PTFB_BACAM (P41029) (304 aa) fasta scores: E(): 1.4e-05, 27.304% id in 293 aa, and to Streptococcus pyogenes regulatory protein SPY0146 TR:Q9A1Q9 (EMBL:AE006484) (339 aa) fasta scores: E(): 8.5e-68, 59.467% id in 338 aa; hypothetical protein 350615 2860937 SAR0307 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039766.1 349584 D 282458 CDS YP_039767.1 49482543 2860938 350958..352076 1 NC_002952.2 Internal region is similar to Exiguobacterium acetylicum guanosine kinase Gsk TR:O24767 (EMBL:AB005149) (303 aa) fasta scores: E(): 4e-09, 26.000% id in 300 aa, Full length CDS is similar to Deinococcus radiodurans PfkB family carbohydrate kinase DR2312 TR:Q9RS15 (EMBL:AE002063) (383 aa) fasta scores: E(): 1.6e-25, 31.389% id in 360 aa. CDS contains an N-terminal helix-turn-helix domain, probable regulatory protein; PfkB family carbohydrate kinase 352076 2860938 SAR0308 Staphylococcus aureus subsp. aureus MRSA252 PfkB family carbohydrate kinase YP_039767.1 350958 D 282458 CDS YP_039768.1 49482544 2860939 352051..352974 1 NC_002952.2 Similar to Escherichia coli hypothetical protein YeiN SW:YEIN_ECOLI (P33025) (312 aa) fasta scores: E(): 5.8e-59, 57.667% id in 300 aa, and to Erwinia chrysanthemi indigoidine systhesis protein IndA TR:Q9L393 (EMBL:AJ277403) (316 aa) fasta scores: E(): 6e-46, 43.478% id in 299 aa; hypothetical protein 352974 2860939 SAR0309 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039768.1 352051 D 282458 CDS YP_039769.1 49482545 2860940 352985..354205 1 NC_002952.2 Similar to Escherichia coli nucleoside permease NupC SW:NUPC_ECOLI (P33031) (400 aa) fasta scores: E(): 7.9e-56, 43.415% id in 410 aa, and to Bacillus halodurans nucleoside transporter BH1446 TR:Q9KCX3 (EMBL:AP001512) (406 aa) fasta scores: E(): 1.6e-38, 32.775% id in 418 aa; nucleoside permease 354205 2860940 SAR0310 Staphylococcus aureus subsp. aureus MRSA252 nucleoside permease YP_039769.1 352985 D 282458 CDS YP_039770.1 49482546 2860941 complement(354310..355842) 1 NC_002952.2 Similar to the N-terminal regions of Rattus norvegicus sodium-dependent multivitamin transporter SMVT SW:SL56_RAT (O70247) (634 aa) fasta scores: E(): 5.9e-33, 27.613% id in 507 aa, and to Homo sapiens sodium-dependent multivitamin transporter SMVT SW:SL56_HUMAN (Q9Y289) (635 aa) fasta scores: E(): 7.8e-32, 26.531% id in 490 aa; sodium:solute symporter family protein 355842 2860941 SAR0311 Staphylococcus aureus subsp. aureus MRSA252 sodium:solute symporter family protein YP_039770.1 354310 R 282458 CDS YP_039771.1 49482547 2860942 complement(355882..356763) 1 NC_002952.2 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 356763 2860942 SAR0312 Staphylococcus aureus subsp. aureus MRSA252 N-acetylneuraminate lyase YP_039771.1 355882 R 282458 CDS YP_039772.1 49482548 2860943 356921..357781 1 NC_002952.2 Similar to Streptomyces coelicolor glucokinase Glk SW:GLK_STRCO (P40184) (317 aa) fasta scores: E(): 8.2e-10, 28.571% id in 287 aa, and to Streptococcus pyogenes glucose kinase SPY0258 TR:Q9A1I4 (EMBL:AE006492) (312 aa) fasta scores: E(): 3.2e-21, 32.986% id in 288 aa; ROK family protein 357781 2860943 SAR0313 Staphylococcus aureus subsp. aureus MRSA252 ROK family protein YP_039772.1 356921 D 282458 CDS YP_039773.1 49482549 2860944 complement(358058..358858) 1 NC_002952.2 Similar to Escherichia coli transcriptional repressor of rpiB expression, RpiR SW:RPIR_ECOLI (P39266) (296 aa) fasta scores: E(): 9.1e-07, 21.923% id in 260 aa, and to Lactococcus lactis transcriptional regulator YljC TR:Q9CGC1 (EMBL:AE006350) (273 aa) fasta scores: E(): 1.2e-13, 25.092% id in 271 aa; hypothetical protein 358858 2860944 SAR0314 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039773.1 358058 R 282458 CDS YP_039774.1 49482550 2860945 358998..359666 1 NC_002952.2 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 359666 2860945 SAR0315 Staphylococcus aureus subsp. aureus MRSA252 N-acetylmannosamine-6-phosphate 2-epimerase YP_039774.1 358998 D 282458 CDS YP_039775.1 49482551 2860946 complement(359792..361105) 1 NC_002952.2 Similar to Vibrio cholerae hypothetical protein VCA0076 TR:Q9KN89 (EMBL:AE004350) (458 aa) fasta scores: E(): 9.5e-32, 29.345% id in 443 aa, and to Bacillus firmus hypothetical protein YkaA SW:YKAA_BACFI (P30267) (463 aa) fasta scores: E(): 1.6e-32, 29.318% id in 440 aa; hypothetical protein 361105 2860946 SAR0316 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039775.1 359792 R 282458 CDS YP_039776.1 49482552 2859913 361522..363597 1 NC_002952.2 Similar to Staphylococcus aureus lipase (glycerol ester hydrolase) precursor Geh SW:LIP_STAAU (P10335) (690 aa) fasta scores: E(): 0, 97.829% id in 691 aa, and to Staphylococcus epidermidis lipase precursor GehD TR:Q9Z4M7 (EMBL:AF090142) (643 aa) fasta scores: E(): 1.1e-83, 44.250% id in 687 aa; lipase precursor 363597 geh 2859913 geh Staphylococcus aureus subsp. aureus MRSA252 lipase precursor YP_039776.1 361522 D 282458 CDS YP_039777.1 49482553 2860947 complement(363839..364666) 1 NC_002952.2 Poor database matches. Similar to Rhodococcus sp hydroxymuconic-semialdehyde hydrolase OhpC TR:Q9KH20 (EMBL:AF274045) (289 aa) fasta scores: E(): 0.51, 23.507% id in 268 aa; hypothetical protein 364666 2860947 SAR0318 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039777.1 363839 R 282458 CDS YP_039778.1 49482554 2860948 complement(364724..365938) 1 NC_002952.2 N-terminus is similar to the N-terminal region of Thermoanaerobacter brockii NADH oxidase SW:NADO_THEBR (P32382) (651 aa) fasta scores: E(): 7.8e-17, 26.554% id in 354 aa. Full length CDS is similar to Streptococcus pyogenes trimethylamine dehydrogenase SPY1219 TR:Q99ZI3 (EMBL:AE006562) (399 aa) fasta scores: E(): 1.1e-92, 56.853% id in 394 aa; NADH:flavin oxidoreductase / NADH oxidase 365938 2860948 SAR0319 Staphylococcus aureus subsp. aureus MRSA252 NADH:flavin oxidoreductase / NADH oxidase YP_039778.1 364724 R 282458 CDS YP_039779.1 49482555 2860949 366246..367247 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY1218 TR:Q99ZI4 (EMBL:AE006562) (332 aa) fasta scores: E(): 1.6e-50, 42.470% id in 332 aa, and to Bacillus subtilis hypothetical protein YwcH SW:YWCH_BACSU (P39606) (333 aa) fasta scores: E(): 6e-39, 38.690% id in 336 aa; luciferase 367247 2860949 SAR0320 Staphylococcus aureus subsp. aureus MRSA252 luciferase YP_039779.1 366246 D 282458 CDS YP_039780.1 49482556 2860950 367281..367613 1 NC_002952.2 Similar to an internal region of Drosophila melanogaster mitochondrial glycine cleavage system H protein Ppl SW:GCSH_DROME (Q9U616) (165 aa) fasta scores: E(): 4.6e-07, 34.653% id in 101 aa. Full length CDS is similar to Streptococcus pyogenes glycine cleavage system H protein SPY1217 TR:Q99ZI5 (EMBL:AE006562) (110 aa) fasta scores: E(): 4.2e-22, 60.000% id in 110 aa; glycine cleavage H-protein 367613 2860950 SAR0321 Staphylococcus aureus subsp. aureus MRSA252 glycine cleavage H-protein YP_039780.1 367281 D 282458 CDS YP_039781.1 49482557 2860951 367614..368414 1 NC_002952.2 Poor database matches. Similar to Streptococcus pyogenes hypothetical protein SPY1216 TR:Q99ZI6 (EMBL:AE006562) (270 aa) fasta scores: E(): 6.5e-39, 47.280% id in 239 aa. C-terminal region of the CDS is similar to Escherichia coli hypothetical protein TR:P75918 (EMBL:AE000206) (177 aa) fasta scores: E(): 1.9e-15, 37.569% id in 181 aa; hypothetical protein 368414 2860951 SAR0322 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039781.1 367614 D 282458 CDS YP_039782.1 49482558 2860952 368401..369348 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY1215 TR:Q99ZI7 (EMBL:AE006562) (293 aa) fasta scores: E(): 1.6e-70, 63.838% id in 271 aa, and to Mycoplasma pulmonis hypothetical protein MYPU_4420 TR:CAC13615 (EMBL:AL445564) (282 aa) fasta scores: E(): 3.8e-55, 50.379% id in 264 aa; hypothetical protein 369348 2860952 SAR0323 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039782.1 368401 D 282458 CDS YP_039783.1 49482559 2860953 369326..370348 1 NC_002952.2 Similar to Escherichia coli lipoate-protein ligase A LplA SW:LPLA_ECOLI (P32099) (337 aa) fasta scores: E(): 6.6e-17, 28.896% id in 308 aa, and to Streptococcus pyogenes lipoate-protein ligase LplA TR:Q99ZI8 (EMBL:AE006562) (339 aa) fasta scores: E(): 2.9e-84, 62.059% id in 340 aa; lipoate-protein ligase A 370348 2860953 SAR0324 Staphylococcus aureus subsp. aureus MRSA252 lipoate-protein ligase A YP_039783.1 369326 D 282458 CDS YP_039784.1 49482560 2860954 370661..371689 1 NC_002952.2 Similar to Gerbera hybrida dihydroflavonol-4-reductase Dfr SW:DFRA_GERHY (P51105) (366 aa) fasta scores: E(): 1.1e-20, 32.931% id in 331 aa, and to Rhizobium loti probable cinnamoyl-CoA reductase MLL1975 TR:BAB49218 (EMBL:AP002998) (355 aa) fasta scores: E(): 1e-40, 37.681% id in 345 aa; reductase 371689 2860954 SAR0325 Staphylococcus aureus subsp. aureus MRSA252 reductase YP_039784.1 370661 D 282458 CDS YP_039785.1 49482561 2860955 complement(371783..373129) 1 NC_002952.2 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 373129 ulaA 2860955 ulaA Staphylococcus aureus subsp. aureus MRSA252 PTS system ascorbate-specific transporter subunit IIC YP_039785.1 371783 R 282458 CDS YP_039786.1 49482562 2860956 complement(373144..373428) 1 NC_002952.2 Similar to Escherichia coli unknown pentitol phosphotransferase enzyme IIB component SgaB SW:PTXB_ECOLI (P39302) (101 aa) fasta scores: E(): 0.18, 29.787% id in 94 aa, and to Escherichia coli hypothetical protein TR:Q9AI23 (EMBL:AF286670) (95 aa) fasta scores: E(): 4.6e-08, 36.082% id in 97 aa; PTS transporter 373428 2860956 SAR0327 Staphylococcus aureus subsp. aureus MRSA252 PTS transporter YP_039786.1 373144 R 282458 CDS YP_039787.1 49482563 2860957 complement(373430..373873) 1 NC_002952.2 Similar to Escherichia coli cryptic mannitol PTS transporter CmtB SW:PTYA_ECOLI (P32058) (147 aa) fasta scores: E(): 4.1e-14, 35.714% id in 140 aa, and to Escherichia coli unknown pentitol phosphotransferase enzyme IIA component SgaA SW:PTXA_ECOLI (P39303) (154 aa) fasta scores: E(): 1.6e-10, 27.273% id in 143 aa; PTS transport system IIA component 373873 2860957 SAR0328 Staphylococcus aureus subsp. aureus MRSA252 PTS transport system IIA component YP_039787.1 373430 R 282458 CDS YP_039788.1 49482564 2861654 complement(373878..375833) 1 NC_002952.2 Similar to Bacillus subtilis cel operon regulator CelR SW:CELR_BACSU (P46321) (641 aa) fasta scores: E(): 3.3e-35, 28.063% id in 506 aa, and to Streptococcus pyogenes transcriptional antiterminator SPY1325 TR:Q99Z99 (EMBL:AE006571) (664 aa) fasta scores: E(): 3.2e-23, 22.430% id in 642 aa; PTS regulator 375833 2861654 SAR0329 Staphylococcus aureus subsp. aureus MRSA252 PTS regulator YP_039788.1 373878 R 282458 CDS YP_039789.1 49482565 2861655 376045..376464 1 NC_002952.2 Similar to Erwinia carotovora antibiotic production and exoenzyme virulence determinants regulatory protein, Hor SW:HOR_ERWCA (Q9RB09) (145 aa) fasta scores: E(): 0.0022, 26.357% id in 129 aa, and to Lactococcus lactis transcriptional regulator RmaE TR:Q9CFJ4 (EMBL:AE006378) (139 aa) fasta scores: E(): 2.7e-10, 29.851% id in 134 aa; MarR family regulatory protein 376464 2861655 SAR0330 Staphylococcus aureus subsp. aureus MRSA252 MarR family regulatory protein YP_039789.1 376045 D 282458 CDS YP_039790.1 49482566 2861656 376571..377926 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YpbC TR:Q9CFJ2 (EMBL:AE006378) (459 aa) fasta scores: E(): 9.6e-53, 38.636% id in 440 aa, and to Thermotoga maritima conserved hypothetical protein TM1701 TR:Q9X227 (EMBL:AE001810) (458 aa) fasta scores: E(): 1.4e-27, 29.787% id in 423 aa; hypothetical protein 377926 2861656 SAR0331 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039790.1 376571 D 282458 CDS YP_039791.1 49482567 2861657 378032..378472 1 NC_002952.2 Poor database matches. Similar to an internal region of Borrelia burgdorferi lipoprotein TR:Q44816 (EMBL:U45424) (203 aa) fasta scores: E(): 9.9, 28.571% id in 133 aa; hypothetical protein 378472 2861657 SAR0332 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039791.1 378032 D 282458 CDS YP_039792.1 49482568 2859929 complement(378556..379914) 1 NC_002952.2 Similar to Bacillus subtilis glycerol-3-phosphate transporter GlpT SW:GLPT_BACSU (P37948) (444 aa) fasta scores: E(): 1.2e-112, 61.863% id in 451 aa, and to Pseudomonas aeruginosa glycerol-3-phosphate transporter GlpT TR:Q9HTV5 (EMBL:AE004936) (448 aa) fasta scores: E(): 1.3e-103, 60.091% id in 441 aa; glycerol-3-phosphate transporter 379914 glpT 2859929 glpT Staphylococcus aureus subsp. aureus MRSA252 glycerol-3-phosphate transporter YP_039792.1 378556 R 282458 CDS YP_039793.1 49482569 2861658 380226..381152 1 NC_002952.2 Similar to Sphingomonas chlorophenolica 2,6-dichloro-p-hydroxyquinone chlorohydrolase PcpA TR:Q9ZBB0 (EMBL:M55159) (320 aa) fasta scores: E(): 9.2e-13, 26.625% id in 323 aa, and to Bacillus subtilis dioxygenase YkcA TR:O34689 (EMBL:Z99110) (316 aa) fasta scores: E(): 3.5e-40, 37.812% id in 320 aa; dioxygenase 381152 2861658 SAR0334 Staphylococcus aureus subsp. aureus MRSA252 dioxygenase YP_039793.1 380226 D 282458 CDS YP_039794.1 49482570 2861659 381166..382227 1 NC_002952.2 Similar to Vibrio fischeri alkanal monooxygenase alpha chain protein LuxA TR:Q9S3Z1 (EMBL:AF170104) (354 aa) fasta scores: E(): 7.1e-07, 22.515% id in 342 aa, and to Bacillus amyloliquefaciens hypothetical protein TR:Q9F9Q6 (EMBL:AF181997) (356 aa) fasta scores: E(): 1.8e-55, 45.115% id in 348 aa; luciferase-like monooxygenase 382227 2861659 SAR0335 Staphylococcus aureus subsp. aureus MRSA252 luciferase-like monooxygenase YP_039794.1 381166 D 282458 CDS YP_039795.1 49482571 2861661 complement(382867..383862) 1 NC_002952.2 Similar to Escherichia coli hypothetical protein YeiH SW:YEIH_ECOLI (P33019) (349 aa) fasta scores: E(): 1.6e-28, 32.381% id in 315 aa, and to Rhizobium loti hypothetical protein MlR2225 TR:BAB49407 (EMBL:AP002999) (325 aa) fasta scores: E(): 9.1e-28, 28.616% id in 318 aa; hypothetical protein 383862 2861661 SAR0338 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039795.1 382867 R 282458 CDS YP_039796.1 49482572 2861662 384222..384767 1 NC_002952.2 Similar to Escherichia coli ribosomal-protein-serine acetyltransferase RimL SW:RIML_ECOLI (P13857) (179 aa) fasta scores: E(): 1.2e-13, 29.586% id in 169 aa, and to Bacillus subtilis probable acetyltransferase YdaF TR:P96579 (EMBL:AB001488) (183 aa) fasta scores: E(): 1.2e-26, 45.405% id in 185 aaSimilar to SAR0718, 68.085% identity (68.085% ungapped) in 329 aa overlap; acetyltransferase 384767 2861662 SAR0339 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_039796.1 384222 D 282458 CDS YP_039797.1 49482573 2861663 385032..385886 1 NC_002952.2 Similar to the C-terminal regions of Streptomyces coelicolor lipoprotein SCC75A.21 TR:Q9RKQ3 (EMBL:AL133220) (384 aa) fasta scores: E(): 2.1e-32, 44.361% id in 266 aa, and Bacillus subtilis hypothetical protein YwbM SW:YWBM_BACSU (P39596) (385 aa) fasta scores: E(): 1.9e-28, 42.353% id in 255 aa; lipoprotein 385886 2861663 SAR0340 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039797.1 385032 D 282458 CDS YP_039798.1 49482574 2861664 385883..387112 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein SW:YWBN_BACSU (P39597) (416 aa) fasta scores: E(): 1.6e-40, 40.338% id in 414 aa, and to Streptomyces coelicolor membrane protein SCC75A.22 TR:Q9RKQ2 (EMBL:AL133220) (420 aa) fasta scores: E(): 4.4e-40, 40.793% id in 429 aa; Sec-independent exported protein 387112 2861664 SAR0341 Staphylococcus aureus subsp. aureus MRSA252 Sec-independent exported protein YP_039798.1 385883 D 282458 CDS YP_039799.1 49482575 2861665 387093..388805 1 NC_002952.2 Similar to the C-terminal regions of Pasteurella multocida hypothetical protein PM0453 TR:Q9CNH8 (EMBL:AE006081) (634 aa) fasta scores: E(): 3.3e-18, 23.304% id in 575 aa, and Campylobacter jejuni integral membrane protein CJ1658 TR:Q9PM19 (EMBL:AL139079) (696 aa) fasta scores: E(): 2.1e-16, 25.497% id in 604 aa; hypothetical protein 388805 2861665 SAR0342 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039799.1 387093 D 282458 CDS YP_039800.1 49482576 2861666 complement(389116..389817) 1 NC_002952.2 Similar to Escherichia coli Sec-independent protein translocase TatC or MttB SWALL:TATC_ECOLI (SWALL:P27857) (258 aa) fasta scores: E(): 2e-15, 30.17% id in 232 aa, and to Bacillus halodurans hypothetical protein BH0553 SW:YDIJ_BACHD (Q9Z9P4) (253 aa) fasta scores: E(): 2.2e-27, 37.229% id in 231 aa; Sec-independent protein translocase 389817 2861666 SAR0343 Staphylococcus aureus subsp. aureus MRSA252 Sec-independent protein translocase YP_039800.1 389116 R 282458 CDS YP_039801.1 49482577 2861667 complement(389834..390049) 1 NC_002952.2 Similar to the N-terminal region of Escherichia coli Sec-independent protein translocase TatA or MttA1 SWALL:TATA_ECOLI (SWALL:O65938) (89 aa) fasta scores: E(): 0.048, 36% id in 50 aa. Full length CDS is similar to Bacillus halodurans hypothetical protein BH3905 TR:Q9K627 (EMBL:AP001520) (68 aa) fasta scores: E(): 1.3e-07, 56.250% id in 64 aa; Sec-independent protein translocase 390049 2861667 SAR0344 Staphylococcus aureus subsp. aureus MRSA252 Sec-independent protein translocase YP_039801.1 389834 R 282458 CDS YP_039802.1 49482578 2861668 complement(390157..390546) 1 NC_002952.2 Poor database matches. Similar to Lactococcus lactis hypothetical protein YcfH TR:Q9CIU6 (EMBL:AE006263) (137 aa) fasta scores: E(): 0.19, 26.400% id in 125 aa; hypothetical protein 390546 2861668 SAR0345 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039802.1 390157 R 282458 CDS YP_039803.1 49482579 2861669 390786..390989 1 NC_002952.2 Similar to Streptococcus pyogenes transcriptional regulator protein SPY1386 TR:Q99Z58 (EMBL:AE006576) (71 aa) fasta scores: E(): 1.3e-14, 65.672% id in 67 aa, and to Archaeoglobus fulgidus hypothetical transcriptional regulator AF1627 SW:YG27_ARCFU (O28646) (71 aa) fasta scores: E(): 1.2e-09, 47.761% id in 67 aa; DNA-binding protein 390989 2861669 SAR0346 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_039803.1 390786 D 282458 CDS YP_039804.1 49482580 2861670 390986..391699 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY1385 TR:Q99Z59 (EMBL:AE006576) (253 aa) fasta scores: E(): 1, 23.016% id in 252 aa, and to an internal region of Bacillus halodurans hypothetical protein BH1986 TR:Q9KBE2 (EMBL:AP001513) (439 aa) fasta scores: E(): 3.5, 27.556% id in 225 aa; hypothetical protein 391699 2861670 SAR0347 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039804.1 390986 D 282458 CDS YP_039805.1 49482581 2861671 391724..392566 1 NC_002952.2 Similar to Bacillus subtilis ATP-binding transport protein NatA SW:NATA_BACSU (P46903) (246 aa) fasta scores: E(): 1.6e-11, 28.854% id in 253 aa, and to Bacillus halodurans ABC transporter BH0652 TR:Q9KF34 (EMBL:AP001509) (288 aa) fasta scores: E(): 4.6e-20, 33.083% id in 266 aa; ABC transporter ATP-binding protein 392566 2861671 SAR0348 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_039805.1 391724 D 282458 CDS YP_039806.1 49482582 2861672 392566..393195 1 NC_002952.2 Similar to Staphylococcus xylosus hypothetical protein TR:O33816 (EMBL:Y14599) (209 aa) fasta scores: E(): 8.7e-32, 48.357% id in 213 aa, and to Butyrivibrio fibrisolvens butyrivibriocin AR10 operon protein BviB TR:Q9ZGP7 (EMBL:AF076529) (216 aa) fasta scores: E(): 0.033, 22.667% id in 225 aa; hypothetical protein 393195 2861672 SAR0349 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039806.1 392566 D 282458 CDS YP_039807.1 49482583 2861673 complement(393564..394697) 1 NC_002952.2 Poor database matches. C-terminus is similar to Listeria monocytogenes low temperature requirement protein A LtrA TR:Q9ZIM4 (EMBL:AF023180) (324 aa) fasta scores: E(): 2.9e-11, 25.387% id in 323 aa. Full length CDS is similar to C-terminal region of Rhizobium meliloti hypothetical protein SW:YSY3_RHIME (O33683) (451 aa) fasta scores: E(): 0.00015, 21.180% id in 373 aa; hypothetical protein 394697 2861673 SAR0350 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039807.1 393564 R 282458 CDS YP_039808.1 49482584 2859529 395237..396418 1 NC_002952.2 Similar to Clostridium acetobutylicum acetyl-CoA acetyltransferase Thl SW:THL_CLOAB (P45359) (392 aa) fasta scores: E(): 5e-81, 57.653% id in 392 aa, and to Clostridium thermosaccharolyticum acetyl coenzyme A acetyltransferase ThlA TR:P77852 (EMBL:Z82038) (392 aa) fasta scores: E(): 1.1e-82, 58.929% id in 392 aa; acetyl-CoA acetyltransferase 396418 thl 2859529 thl Staphylococcus aureus subsp. aureus MRSA252 acetyl-CoA acetyltransferase YP_039808.1 395237 D 282458 CDS YP_039809.1 49482585 2861674 complement(396501..397253) 1 NC_002952.2 Similar to Pasteurella multocida hypothetical protein PM0097 TR:Q9CPE7 (EMBL:AE006045) (247 aa) fasta scores: E(): 7.6e-50, 51.867% id in 241 aa, and to Rhizobium loti hypothetical protein MLR5444 TR:BAB51895 (EMBL:AP003006) (263 aa) fasta scores: E(): 3.3e-19, 32.500% id in 240 aa; hypothetical protein 397253 2861674 SAR0352 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039809.1 396501 R 282458 CDS YP_039810.1 49482586 2861162 complement(397296..399524) 1 NC_002952.2 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 399524 metE 2861162 metE Staphylococcus aureus subsp. aureus MRSA252 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_039810.1 397296 R 282458 CDS YP_039811.1 49482587 2861675 complement(399521..401362) 1 NC_002952.2 catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase 401362 2861675 SAR0354 Staphylococcus aureus subsp. aureus MRSA252 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase YP_039811.1 399521 R 282458 CDS YP_039812.1 49482588 2861676 complement(401331..402491) 1 NC_002952.2 Similar to Lactococcus lactis (subsp. cremoris) (Streptococcus cremoris) cystathionine beta-lyase MetC TR:Q9RAS9 (EMBL:AF131880) (380 aa) fasta scores: E(): 8e-61, 47.887% id in 355 aa, and to Lactobacillus reuteri cystathionine beta-lyase TR:Q9FCU8 (EMBL:AJ293860) (380 aa) fasta scores: E(): 8.2e-66, 49.304% id in 359 aa; Cys/Met metabolism PLP-dependent enzyme 402491 2861676 SAR0355 Staphylococcus aureus subsp. aureus MRSA252 Cys/Met metabolism PLP-dependent enzyme YP_039812.1 401331 R 282458 CDS YP_039813.1 49482589 2861677 complement(402488..403591) 1 NC_002952.2 Similar to Lactococcus lactis (subsp. cremoris) (Streptococcus cremoris) cystathionine beta-lyase MetC TR:Q9RAS9 (EMBL:AF131880) (380 aa) fasta scores: E(): 3.6e-39, 41.096% id in 365 aa, and to Bacillus subtilis hypothetical protein YjcI TR:O31631 (EMBL:Z99110) (373 aa) fasta scores: E(): 2e-66, 49.863% id in 365 aa; Cys/Met metabolism PLP-dependent enzyme 403591 2861677 SAR0356 Staphylococcus aureus subsp. aureus MRSA252 Cys/Met metabolism PLP-dependent enzyme YP_039813.1 402488 R 282458 CDS YP_039814.1 49482590 2861678 404255..405100 1 NC_002952.2 Similar to Bacillus subtilis stage 0 sporulation protein T Spo0J SW:SP0J_BACSU (P26497) (282 aa) fasta scores: E(): 1.3e-37, 45.802% id in 262 aa, and to Listeria monocytogenes hypothetical protein ParB TR:Q9FCV8 (EMBL:AJ010494) (283 aa) fasta scores: E(): 1.3e-40, 49.811% id in 265 aa; DNA-binding protein 405100 2861678 SAR0357 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_039814.1 404255 D 282458 CDS YP_039815.1 49482591 2861679 405254..406135 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2666 TR:Q9K9I1 (EMBL:AP001516) (276 aa) fasta scores: E(): 9.8e-26, 34.815% id in 270 aa, and to Bacillus subtilis hypothetical protein YkuT TR:O34897 (EMBL:AJ222587) (267 aa) fasta scores: E(): 2.4e-22, 35.772% id in 246 aa; hypothetical protein 406135 2861679 SAR0358 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039815.1 405254 D 282458 CDS YP_039816.1 49482592 2861680 406165..406368 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH4052 TR:Q9K5N6 (EMBL:AP001520) (65 aa) fasta scores: E(): 6.3e-13, 54.237% id in 59 aa, and to Streptococcus pyogenes hypothetical protein SPY0004 TR:Q9A208 (EMBL:AE006472) (65 aa) fasta scores: E(): 4.4e-09, 50.000% id in 62 aa; hypothetical protein 406368 2861680 SAR0359 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039816.1 406165 D 282458 CDS YP_039817.1 49482593 2861681 406380..407477 1 NC_002952.2 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 407477 2861681 SAR0360 Staphylococcus aureus subsp. aureus MRSA252 GTP-dependent nucleic acid-binding protein EngD YP_039817.1 406380 D 282458 CDS YP_039818.1 49482594 2861682 complement(407563..407754) 1 NC_002952.2 hypothetical protein 407754 2861682 SAR0361 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039818.1 407563 R 282458 CDS YP_039819.1 49482595 2860177 407998..408294 1 NC_002952.2 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 408294 rpsF 2860177 rpsF Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S6 YP_039819.1 407998 D 282458 CDS YP_039820.1 49482596 2859505 408315..408818 1 NC_002952.2 Similar to Bacillus subtilis single-strand binding protein Ssb SW:SSB_BACSU (P37455) (172 aa) fasta scores: E(): 7.6e-40, 67.429% id in 175 aa, and to bacteriophage A118 single-strand binding protein Ssb protein TR:Q9T160 (EMBL:AJ242593) (160 aa) fasta scores: E(): 8.1e-35, 59.281% id in 167 aa. Similar to SAR2083, 68.862% identity (73.718% ungapped) in 167 aa overlap; single-strand DNA-binding protein 408818 ssb 2859505 ssb Staphylococcus aureus subsp. aureus MRSA252 single-strand DNA-binding protein YP_039820.1 408315 D 282458 CDS YP_039821.1 49482597 2861454 408870..409112 1 NC_002952.2 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 409112 rpsR 2861454 rpsR Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S18 YP_039821.1 408870 D 282458 CDS YP_039822.1 49482598 2861683 complement(409344..410063) 1 NC_002952.2 Poor database matches. Similar to the C-terminal regions of Streptococcus pyogenes conserved hypothetical protein-phage associated protein SPY0938 TR:Q9A043 (EMBL:AE006542) (269 aa) fasta scores: E(): 4.1e-09, 30.638% id in 235 aa, and to Cryptosporidium parvum hypothetical protein TR:Q9GRY1 (EMBL:AJ293269) (483 aa) fasta scores: E(): 7.5, 25.941% id in 239 aa; hypothetical protein 410063 2861683 SAR0365 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039822.1 409344 R 282458 CDS YP_039823.1 49482599 2861684 complement(410176..411390) 1 NC_002952.2 Similar to bacteriophage phi PVL, and Staphylococcus aureus temperate phage phiSLT, integrase TR:O80068 (EMBL:AB009866) (401 aa) fasta scores: E(): 2e-52, 38.765% id in 405 aa, and to bacteriophage bIL312 integrase Int TR:Q9AZF9 (EMBL:AF323673) (382 aa) fasta scores: E(): 1e-15, 35.468% id in 406 aa; integrase 411390 2861684 SAR0366 Staphylococcus aureus subsp. aureus MRSA252 integrase YP_039823.1 410176 R 282458 CDS YP_039824.1 49482600 2861685 complement(411551..412174) 1 NC_002952.2 Similar to bacteriophage bIL311 cI-like repressor TR:Q9AZH9 (EMBL:AF323672) (235 aa) fasta scores: E(): 1.9, 25.822% id in 213 aa, and to Staphylococcus aureus pathogenicity island protein Orf20 TR:Q9F0J8 (EMBL:AF217235) (267 aa) fasta scores: E(): 1.4, 26.961% id in 204 aa; DNA-binding protein 412174 2861685 SAR0367 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_039824.1 411551 R 282458 CDS YP_039825.1 49482601 2861223 412269..412487 1 NC_002952.2 Similar to bacteriophage SPP1 hypothetical protein Orf37.3 TR:Q38149 (EMBL:X67865) (57 aa) fasta scores: E(): 2.7, 27.660% id in 47 aa, and to Streptomyces coelicolor hypothetical protein SCE68.26C TR:Q9WX06 (EMBL:AL079345) (70 aa) fasta scores: E(): 0.5, 29.091% id in 55 aa; DNA-binding protein 412487 2861223 SAR0368 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_039825.1 412269 D 282458 CDS YP_039826.1 49482602 2861224 412488..412760 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf37 TR:O80076 (EMBL:AB009866) (87 aa) fasta scores: E(): 2.3e-07, 37.079% id in 89 aa, and to Staphylococcus aureus temperate phage phiSLT hypothetical protein TR:Q9B0G8 (EMBL:AB045978) (87 aa) fasta scores: E(): 2.6e-06, 33.708% id in 89 aa; hypothetical protein 412760 2861224 SAR0369 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039826.1 412488 D 282458 CDS YP_039827.1 49482603 2861225 412772..412945 1 NC_002952.2 hypothetical protein 412945 2861225 SAR0370 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039827.1 412772 D 282458 CDS YP_039828.1 49482604 2861226 412912..413058 1 NC_002952.2 hypothetical protein 413058 2861226 SAR0371 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039828.1 412912 D 282458 CDS YP_039829.1 49482605 2861227 413116..413499 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf17 TR:Q9F0K1 (EMBL:AF217235) (127 aa) fasta scores: E(): 4.9e-47, 98.425% id in 127 aa; hypothetical protein 413499 2861227 SAR0372 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039829.1 413116 D 282458 CDS YP_039830.1 49482606 2861228 413500..413826 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf16 TR:Q9F0K2 (EMBL:AF217235) (105 aa) fasta scores: E(): 3.2e-14, 45.370% id in 108 aa; hypothetical protein 413826 2861228 SAR0373 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039830.1 413500 D 282458 CDS YP_039831.1 49482607 2861229 413891..414760 1 NC_002952.2 Similar to Lactococcus bacteriophage phi31 hypothetical protein TR:Q9G0E4 (EMBL:AJ292531) (268 aa) fasta scores: E(): 0.0017, 21.961% id in 255 aa, and to Staphylococcus aureus pathogenicity island protein Orf15 TR:Q9F0K3 (EMBL:AF217235) (289 aa) fasta scores: E(): 1.3e-116, 95.502% id in 289 aa; hypothetical protein 414760 2861229 SAR0374 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039831.1 413891 D 282458 CDS YP_039832.1 49482608 2861230 414774..416483 1 NC_002952.2 Poor database matches. N-terminus is similar to Staphylococcus aureus pathogenicity island protein Orf14 TR:Q9F0K4 (EMBL:AF217235) (278 aa) fasta scores: E(): 4.9e-95, 98.545% id in 275 aa. and C-terminus is similar to Staphylococcus aureus pathogenicity island protein Orf13 TR:Q9F0K5 (EMBL:AF217235) (293 aa) fasta scores: E(): 4.5e-94, 89.273% id in 289 aa; hypothetical protein 416483 2861230 SAR0375 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039832.1 414774 D 282458 CDS YP_039833.1 49482609 2861231 416793..417173 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf12 TR:Q9F0K6 (EMBL:AF217235) (126 aa) fasta scores: E(): 1.3e-49, 96.825% id in 126 aa; hypothetical protein 417173 2861231 SAR0376 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039833.1 416793 D 282458 CDS YP_039834.1 49482610 2861232 417170..417811 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf11 TR:Q9F0K7 (EMBL:AF217235) (213 aa) fasta scores: E(): 8.4e-76, 93.897% id in 213 aa; hypothetical protein 417811 2861232 SAR0377 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039834.1 417170 D 282458 CDS YP_039835.1 49482611 2861233 418519..418863 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf10 TR:Q9F0K8 (EMBL:AF217235) (113 aa) fasta scores: E(): 8.4e-38, 91.667% id in 108 aa; hypothetical protein 418863 2861233 SAR0378 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039835.1 418519 D 282458 CDS YP_039836.1 49482612 2861234 418894..419547 1 NC_002952.2 Poor database matches. Similar to Plasmodium falciparum hypothetical protein PFC0075c TR:O97331 (EMBL:AL034560) (284 aa) fasta scores: E(): 1.7, 26.154% id in 195 aa; hypothetical protein 419547 2861234 SAR0379 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039836.1 418894 D 282458 CDS YP_039837.1 49482613 2861235 419600..420127 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf7 TR:Q9F0L1 (EMBL:AF217235) (191 aa) fasta scores: E(): 7.7e-61, 96.000% id in 175 aa. CDS is truncated at the C-terminus in comparison to the pathogenicity island protein; hypothetical protein 420127 2861235 SAR0380 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039837.1 419600 D 282458 CDS YP_039838.1 49482614 2861236 420130..420471 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf6 TR:Q9F0L2 (EMBL:AF217235) (113 aa) fasta scores: E(): 2.4e-40, 93.805% id in 113 aa; hypothetical protein 420471 2861236 SAR0381 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039838.1 420130 D 282458 CDS YP_039839.1 49482615 2861237 420468..421037 1 NC_002952.2 Similar to bacteriophage SF6, and bacteriophage rho-15 terminase small subunit SW:TERS_BPSF6 (Q38627) (151 aa) fasta scores: E(): 8.6e-06, 34.568% id in 162 aa, and to Staphylococcus aureus pathogenicity island protein Orf5 TR:Q9F0L3 (EMBL:AF217235) (189 aa) fasta scores: E(): 6.2e-67, 97.884% id in 189 aa; terminase small subunit 421037 2861237 SAR0382 Staphylococcus aureus subsp. aureus MRSA252 terminase small subunit YP_039839.1 420468 D 282458 CDS YP_039840.2 331008297 2861238 421314..422282 1 NC_002952.2 No significant database matches to the full length CDS. C-terminus is similar to C-terminal region of Lactococcus lactis plasmid (pNP40) abortive bacteriophage infection protein AbiF TR:Q48618 (EMBL:U36837) (342 aa) fasta scores: E(): 0.00068, 22.857% id in 280 aa. N-terminus is similar to N-terminal region of Pasteurella multocida hypothetical protein PM1540 TR:Q9CKR6 (EMBL:AE006190) (309 aa) fasta scores: E(): 1.3e-08, 24.731% id in 279 aa; hypothetical protein 422282 2861238 SAR0383 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039840.2 421314 D 282458 CDS YP_039841.1 49482617 2861239 422460..422861 1 NC_002952.2 Poor database matches. Similar to an internal region of Streptococcus thermophilus bacteriophage 7201 hypothetical protein Orf2 TR:Q9MCM9 (EMBL:AF145054) (175 aa) fasta scores: E(): 1.8e-08, 36.290% id in 124 aa; hypothetical protein 422861 2861239 SAR0384 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039841.1 422460 D 282458 CDS YP_039842.1 49482618 2861240 422979..423491 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf3 TR:Q9F0L5 (EMBL:AF217235) (170 aa) fasta scores: E(): 1.3e-50, 99.412% id in 170 aa; hypothetical protein 423491 2861240 SAR0385 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039842.1 422979 D 282458 CDS YP_039843.1 49482619 2861241 complement(424449..425456) 1 NC_002952.2 Poor database matches. Weakly similar to Pasteurella multocida hypothetical protein PM1540 TR:Q9CKR6 (EMBL:AE006190) (309 aa) fasta scores: E(): 9.9, 22.101% id in 276 aa; hypothetical protein 425456 2861241 SAR0386 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039843.1 424449 R 282458 CDS YP_039844.1 49482620 2861243 426413..426781 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YxeA SW:YXEA_BACSU (P54940) (115 aa) fasta scores: E(): 2.7e-06, 29.091% id in 110 aa, and to Lactococcus lactis hypothetical protein YpaG TR:Q9CFJ9 (EMBL:AE006378) (115 aa) fasta scores: E(): 9e-05, 31.405% id in 121 aa; hypothetical protein 426781 2861243 SAR0389 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039844.1 426413 D 282458 CDS YP_039845.1 49482621 2860894 426962..427534 1 NC_002952.2 Similar to Campylobacter jejuni acidic periplasmic protein CJ0424 TR:Q9PI81 (EMBL:AL139075) (210 aa) fasta scores: E(): 0.93, 25.500% id in 200 aa. C-terminus is similar to the C-terminal region of Bacillus subtilis hypothetical protein YkoI TR:O34551 (EMBL:AJ002571) (226 aa) fasta scores: E(): 0.29, 24.138% id in 145 aa; hypothetical protein 427534 2860894 SAR0390 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039845.1 426962 D 282458 CDS YP_039846.1 49482622 2860454 complement(427672..427935) 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Lactococcus lactis transcriptional regulator YnaB TR:Q9CG39 (EMBL:AE006359) (252 aa) fasta scores: E(): 4.3, 27.273% id in 77 aa; hypothetical protein 427935 2860454 SAR0391 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039846.1 427672 R 282458 CDS YP_039847.1 49482623 2860455 428229..428483 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdaS TR:P96594 (EMBL:AB001488) (85 aa) fasta scores: E(): 9.2e-11, 46.429% id in 84 aa, and to Lactococcus lactis hypothetical protein YmgJ TR:Q9CG68 (EMBL:AE006356) (80 aa) fasta scores: E(): 6.6e-08, 46.479% id in 71 aa; hypothetical protein 428483 2860455 SAR0392 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039847.1 428229 D 282458 CDS YP_039848.1 49482624 2860456 complement(428522..428731) 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 428731 2860456 SAR0393 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039848.1 428522 R 282458 CDS YP_039849.1 49482625 2860457 428909..429490 1 NC_002952.2 Similar to Schizosaccharomyces pombe phosphoglycerate mutase SPAC26F1.06 SW:PMGY_SCHPO (P36623) (211 aa) fasta scores: E(): 3.7e-05, 25.000% id in 196 aa, and to Rhizobium loti phosphoglycerate mutase MLR4643 TR:BAB51251 (EMBL:AP003004) (206 aa) fasta scores: E(): 3.2e-07, 29.146% id in 199 aa; phosphoglycerate mutase 429490 2860457 SAR0394 Staphylococcus aureus subsp. aureus MRSA252 phosphoglycerate mutase YP_039849.1 428909 D 282458 CDS YP_039850.1 49482626 2860458 complement(429556..429939) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdeH TR:P96665 (EMBL:AB001488) (148 aa) fasta scores: E(): 0.00021, 27.344% id in 128 aa. CDS is truncated at the N-terminus in comparison to B. subtilis protein; hypothetical protein 429939 2860458 SAR0395 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039850.1 429556 R 282458 CDS YP_039851.1 49482627 2859050 430027..430134 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 430134 2859050 SAR395a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039851.1 430027 D 282458 CDS YP_039852.1 49482628 2860459 complement(430210..430836) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkyA SW:YKYA_BACSU (P21884) (237 aa) fasta scores: E(): 0.71, 23.077% id in 221 aa, and to Bacillus subtilis hypothetical protein YkyA TR:Q45496 (EMBL:AF012285) (205 aa) fasta scores: E(): 4.1, 22.927% id in 205 aa; hypothetical protein 430836 2860459 SAR0396 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039852.1 430210 R 282458 CDS YP_039853.1 49482629 2860460 complement(430909..432528) 1 NC_002952.2 Similar to an internal region of Amsacta moorei entomopoxvirus hypothetical protein AMV156 TR:Q9EMP3 (EMBL:AF250284) (1238 aa) fasta scores: E(): 0.81, 19.540% id in 522 aa. Internal region of the CDS is similar to N-terminal region of bacteriophage SPBc2 hypothetical protein YolJ TR:O64036 (EMBL:AF020713) (422 aa) fasta scores: E(): 0.98, 20.323% id in 310 aa; hypothetical protein 432528 2860460 SAR0397 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039853.1 430909 R 282458 CDS YP_039854.1 49482630 2860986 complement(432643..434166) 1 NC_002952.2 Similar to Xanthomonas campestris alkyl hydroperoxide reductase subunit F AhpF SW:AHPF_XANCH (O06465) (530 aa) fasta scores: E(): 1.8e-95, 53.876% id in 516 aa. Previously sequenced as Staphylococcus aureus alkyl hydroperoxide reductase subunit F AhpF SW:AHPF_STAAU (O05204) (507 aa) fasta scores: E(): 2.9e-181, 98.817% id in 507 aa; alkyl hydroperoxide reductase subunit F 434166 ahpF 2860986 ahpF Staphylococcus aureus subsp. aureus MRSA252 alkyl hydroperoxide reductase subunit F YP_039854.1 432643 R 282458 CDS YP_039855.1 49482631 2860985 complement(434182..434751) 1 NC_002952.2 Similar to Salmonella typhimurium alkyl hydroperoxide reductase, C22 protein, AhpC SW:AHPC_SALTY (P19479) (186 aa) fasta scores: E(): 5.2e-47, 65.426% id in 188 aa. Previously sequenced as Staphylococcus aureus, and alkyl hydroperoxide reductase subunit C AhpC TR:Q53647 (EMBL:U92441) (189 aa) fasta scores: E(): 5.1e-74, 100.000% id in 189 aa; alkyl hydroperoxide reductase subunit C 434751 ahpC 2860985 ahpC Staphylococcus aureus subsp. aureus MRSA252 alkyl hydroperoxide reductase subunit C YP_039855.1 434182 R 282458 CDS YP_039856.1 49482632 2860461 435242..435997 1 NC_002952.2 Similar to Vibrio harveyi NADPH-flavin oxidoreductase Frp SW:FRP_VIBHA (Q56691) (240 aa) fasta scores: E(): 2.8e-28, 36.400% id in 250 aa, and to Bacillus subtilis nitro/flavin reductase NfrA SW:NFRA_BACSU (P39605) (249 aa) fasta scores: E(): 8e-37, 42.105% id in 247 aa; nitroreductase 435997 2860461 SAR0400 Staphylococcus aureus subsp. aureus MRSA252 nitroreductase YP_039856.1 435242 D 282458 CDS YP_039857.1 49482633 2860462 complement(436077..437465) 1 NC_002952.2 Similar to Escherichia coli proton glutamate symport protein GltP SW:GLTP_ECOLI (P21345) (437 aa) fasta scores: E(): 2.4e-22, 25.459% id in 436 aa, and to Bacillus subtilis hypothetical symporter YhcL SW:YHCL_BACSU (P54596) (463 aa) fasta scores: E(): 1.8e-102, 61.283% id in 452 aa; sodium:dicarboxylate symporter protein 437465 2860462 SAR0401 Staphylococcus aureus subsp. aureus MRSA252 sodium:dicarboxylate symporter protein YP_039857.1 436077 R 282458 CDS YP_039858.1 49482634 2860463 437550..437651 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 437651 2860463 SAR0401a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039858.1 437550 D 282458 CDS YP_039859.1 49482635 2860464 complement(438408..438569) 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 438569 2860464 SAR0402 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039859.1 438408 R 282458 CDS YP_039860.1 49482636 2861529 complement(438584..439540) 1 NC_002952.2 hypothetical protein 439540 2861529 SAR0403 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039860.1 438584 R 282458 CDS YP_039861.1 49482637 2861530 complement(439658..440320) 1 NC_002952.2 hypothetical protein 440320 2861530 SAR0404 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039861.1 439658 R 282458 CDS YP_039862.1 49482638 2861531 complement(440463..440870) 1 NC_002952.2 hypothetical protein 440870 2861531 SAR0405 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039862.1 440463 R 282458 CDS YP_039863.1 49482639 2860432 441383..441961 1 NC_002952.2 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 441961 xpt 2860432 xpt Staphylococcus aureus subsp. aureus MRSA252 xanthine phosphoribosyltransferase YP_039863.1 441383 D 282458 CDS YP_039864.1 49482640 2861480 441961..443229 1 NC_002952.2 Similar to Bacillus subtilis xanthine permease PbuX SW:PBUX_BACSU (P42086) (438 aa) fasta scores: E(): 4.8e-82, 56.532% id in 421 aa, and to Lactococcus lactis xanthine permease PbuX TR:Q9CGE9 (EMBL:AE006347) (434 aa) fasta scores: E(): 9.8e-71, 48.471% id in 425 aa; xanthine permease 443229 pbuX 2861480 pbuX Staphylococcus aureus subsp. aureus MRSA252 xanthine permease YP_039864.1 441961 D 282458 CDS YP_039865.1 49482641 2859948 443267..444733 1 NC_002952.2 Similar to Bacillus subtilis inosine-5'-monophosphate dehydrogenase GuaB SW:IMDH_BACSU (P21879) (513 aa) fasta scores: E(): 1.1e-130, 76.923% id in 481 aa, and to Bacillus halodurans inositol-monophosphate dehydrogenase GuaB TR:Q9KGN8 (EMBL:AP001507) (485 aa) fasta scores: E(): 8.1e-130, 74.029% id in 489 aa; inosine-5'-monophosphate dehydrogenase 444733 guaB 2859948 guaB Staphylococcus aureus subsp. aureus MRSA252 inosine-5'-monophosphate dehydrogenase YP_039865.1 443267 D 282458 CDS YP_039866.1 49482642 2859947 444758..446299 1 NC_002952.2 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 446299 guaA 2859947 guaA Staphylococcus aureus subsp. aureus MRSA252 GMP synthase YP_039866.1 444758 D 282458 CDS YP_039867.1 49482643 2861532 complement(446829..447365) 1 NC_002952.2 hypothetical protein 447365 2861532 SAR0411 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039867.1 446829 R 282458 CDS YP_039868.1 49482644 2861534 complement(448771..448947) 1 NC_002952.2 hypothetical protein 448947 2861534 SAR0414 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039868.1 448771 R 282458 CDS YP_039869.1 49482645 2861537 complement(449607..>449954) 1 NC_002952.2 Internal region is similar to Escherichia coli sequence element IS911b transposase InsN SW:INN2_ECOLI (P39212) (100 aa) fasta scores: E(): 0.022, 29.885% id in 87 aa, and to Bacillus halodurans transposase TR:Q9JWP9 (EMBL:AP001518) (94 aa) fasta scores: E(): 1.4e-14, 54.839% id in 93 aa. CDS does not contain a conventional translational start codon; transposase >449954 2861537 SAR0416 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_039869.1 449607 R 282458 CDS YP_039870.1 49482646 2861538 complement(450191..450352) 1 NC_002952.2 hypothetical protein 450352 2861538 SAR0418 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039870.1 450191 R 282458 CDS YP_039871.1 49482647 2861539 complement(450752..450871) 1 NC_002952.2 hypothetical protein 450871 2861539 SAR0419 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039871.1 450752 R 282458 CDS YP_039872.1 49482648 2861540 complement(450865..451224) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YtrP SW:YTRP_LACLA (Q02009) (119 aa) fasta scores: E(): 4e-19, 54.310% id in 116 aa, and to Neisseria meningitidis hypothetical protein NMB0528 TR:Q9K0Q6 (EMBL:AE002408) (123 aa) fasta scores: E(): 2.8e-08, 32.231% id in 121 aa; hypothetical protein 451224 2861540 SAR0420 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039872.1 450865 R 282458 CDS YP_039873.1 49482649 2861541 complement(451243..452088) 1 NC_002952.2 Similar to Rhizobium loti hypothetical protein MLR1414 TR:BAB48794 (EMBL:AP002997) (297 aa) fasta scores: E(): 1e-15, 29.655% id in 290 aa, and to Escherichia coli hypothetical protein YtfG SW:YTFG_ECOLI (P39315) (286 aa) fasta scores: E(): 2e-15, 30.714% id in 280 aa; hypothetical protein 452088 2861541 SAR0421 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039873.1 451243 R 282458 CDS YP_039874.1 49482650 2861542 452560..453240 1 NC_002952.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 453240 2861542 SAR0422 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein YP_039874.1 452560 D 282458 CDS YP_039875.1 49482651 2861543 453523..454224 1 NC_002952.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 454224 2861543 SAR0423 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein YP_039875.1 453523 D 282458 CDS YP_039876.1 49482652 2861544 454512..455543 1 NC_002952.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 455543 2861544 SAR0424 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein YP_039876.1 454512 D 282458 CDS YP_039877.1 49482653 2861545 455890..456810 1 NC_002952.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 456810 2861545 SAR0425 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein YP_039877.1 455890 D 282458 CDS YP_039878.1 49482654 2861546 456957..457082 1 NC_002952.2 hypothetical protein 457082 2861546 SAR0426 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039878.1 456957 D 282458 CDS YP_039879.1 49482655 2859140 457171..457875 1 NC_002952.2 SSL5, SET3, SET10; bind P-selectin glycoprotein ligand-1 and inhibit P-selectin-mediated neutrophil rolling along the endothelium; these proteins share structural homology to known superantigens but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 5 457875 set3 2859140 set3 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein 5 YP_039879.1 457171 D 282458 CDS YP_039880.1 49482656 2859139 458322..459017 1 NC_002952.2 SSL7, SET1; blocks IgA-FcR interactions and inhibits complement, leading to increased survival of a sensitive bacterium in blood; superantigen-like protein 7 459017 set1 2859139 set1 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein 7 YP_039880.1 458322 D 282458 CDS YP_039881.1 49482657 2859142 459358..460056 1 NC_002952.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 460056 set5 2859142 set5 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein YP_039881.1 459358 D 282458 CDS YP_039882.1 49482658 2859141 460419..461102 1 NC_002952.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 461102 set4 2859141 set4 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein YP_039882.1 460419 D 282458 CDS YP_039883.1 49482659 2861547 461180..461311 1 NC_002952.2 hypothetical protein 461311 2861547 SAR0432 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039883.1 461180 D 282458 CDS YP_039884.1 49482660 2861548 461364..462920 1 NC_002952.2 Similar to Escherichia coli type I restriction enzyme EcoR124II modification protein HsdM SW:T1M1_ECOLI (P10484) (520 aa) fasta scores: E(): 1.8e-74, 42.578% id in 512 aa, and to Streptococcus thermophilus type I modification subunit HsdM TR:Q9RNW1 (EMBL:AF177167) (531 aa) fasta scores: E(): 1.1e-85, 49.031% id in 516 aa. Similar to SAR1899, 98.456% identity (98.456% ungapped) in 518 aa overlap; type I restriction enzyme modification protein 462920 2861548 SAR0433 Staphylococcus aureus subsp. aureus MRSA252 type I restriction enzyme modification protein YP_039884.1 461364 D 282458 CDS YP_039885.1 49482661 2861549 462913..464145 1 NC_002952.2 Similar to Lactococcus lactis type I restriction and modification system specificity subunit HsdS TR:Q9AJ85 (EMBL:AF142640) (410 aa) fasta scores: E(): 1.7e-20, 26.545% id in 437 aa, and to Streptococcus thermophilus restriction modification system specificity subunit HsdS TR:Q9RNW6 (EMBL:AF177166) (419 aa) fasta scores: E(): 2.6e-09, 24.775% id in 444 aa; restriction and modification system specificity protein 464145 2861549 SAR0434 Staphylococcus aureus subsp. aureus MRSA252 restriction and modification system specificity protein YP_039885.1 462913 D 282458 CDS YP_039886.1 49482662 2861550 464528..465226 1 NC_002952.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 465226 2861550 SAR0435 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein YP_039886.1 464528 D 282458 CDS YP_039887.1 49482663 2861551 465245..466732 1 NC_002952.2 Poor database matches. Similar to Campylobacter jejuni hypothetical protein CJ0849c TR:Q9PP74 (EMBL:AL139076) (719 aa) fasta scores: E(): 0.28, 22.388% id in 402 aa, and to Saccharomyces cerevisiae intracellular protein transport protein Uso1 SW:USO1_YEAST (P25386) (1790 aa) fasta scores: E(): 2.2, 22.609% id in 460 aa; hypothetical protein 466732 2861551 SAR0436 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039887.1 465245 D 282458 CDS YP_039888.1 49482664 2861552 complement(466838..467146) 1 NC_002952.2 hypothetical protein 467146 2861552 SAR0437 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039888.1 466838 R 282458 CDS YP_039889.1 49482665 2861553 467510..468295 1 NC_002952.2 No significant database matches. Similar to SAR0439, 63.672% identity (63.922% ungapped) in 256 aa overlap, SAR0442, 63.118% identity (63.602% ungapped) in 263 aa overlap, SAR0443, 60.902% identity (62.548% ungapped) in 266 aa overlap, and SAR0444, 52.107% identity (52.918% ungapped) in 261 aa overlap; lipoprotein 468295 2861553 SAR0438 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039889.1 467510 D 282458 CDS YP_039890.1 49482666 2861554 468343..469116 1 NC_002952.2 No significant database matches. Similar to SAR0442, 78.210% identity (78.516% ungapped) in 257 aa overlap, SAR0443, 77.692% identity (78.906% ungapped) in 260 aa overlap, and SAR0438, 63.672% identity (63.922% ungapped) in 256 aa overlap; lipoprotein 469116 2861554 SAR0439 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039890.1 468343 D 282458 CDS YP_039891.1 49482667 2861556 469987..470757 1 NC_002952.2 No significant database matches. Similar to SAR0439, 78.210% identity (78.516% ungapped) in 257 aa overlap, SAR0443, 76.154% identity (77.647% ungapped) in 260 aa overlap, SAR0438, 63.118% identity (63.602% ungapped) in 263 aa overlap, and SAR0444, 56.757% identity (57.647% ungapped) in 259 aa overlap. Appears to have an uncleavable N-terminal signal sequence; hypothetical protein 470757 2861556 SAR0442 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039891.1 469987 D 282458 CDS YP_039892.1 49482668 2861557 470789..471589 1 NC_002952.2 No significant database matches. Similar to SAR0439, 77.692% identity (78.906% ungapped) in 260 aa overlap, SAR0442, 76.154% identity (77.647% ungapped) in 260 aa overlap, and SAR0438, 60.902% identity (62.548% ungapped) in 266 aa overlap; lipoprotein 471589 2861557 SAR0443 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039892.1 470789 D 282458 CDS YP_039893.1 49482669 2861558 471608..472402 1 NC_002952.2 No significant database matches. Similar to SAR2573, 64.314% identity (64.822% ungapped) in 255 aa overlap, SAR0106, 63.118% identity (65.613% ungapped) in 263 aa overlap, SAR2570, 61.923% identity (62.403% ungapped) in 260 aa overlap, SAR0445, 55.351% identity (57.034% ungapped) in 271 aa overlap, SAR0442, 56.757% identity (57.647% ungapped) in 259 aa overlap, SAR0438, 52.107% identity (52.918% ungapped) in 261 aa overlap, and SAR0443, 50.951% identity (52.344% ungapped) in 263 aa overlap; lipoprotein 472402 2861558 SAR0444 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039893.1 471608 D 282458 CDS YP_039894.1 49482670 2860895 472568..473389 1 NC_002952.2 No significant database matches. Similar to SAR0444, 55.351% identity (57.034% ungapped) in 271 aa overlap, SAR2573, 50.373% identity (52.326% ungapped) in 268 aa overlap, and SAR0106, 50.000% identity (53.571% ungapped) in 270 aa overlap; lipoprotein 473389 2860895 SAR0445 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039894.1 472568 D 282458 CDS YP_039895.1 49482671 2860036 474706..475029 1 NC_002952.2 hypothetical protein 475029 2860036 SAR0447 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039895.1 474706 D 282458 CDS YP_039896.1 49482672 2860037 475048..475362 1 NC_002952.2 hypothetical protein 475362 2860037 SAR0448 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039896.1 475048 D 282458 CDS YP_039897.1 49482673 2860001 complement(475651..475845) 1 NC_002952.2 hypothetical protein 475845 2860001 SAR0449 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039897.1 475651 R 282458 CDS YP_039898.1 49482674 2859555 476030..477232 1 NC_002952.2 Similar to Pseudomonas chlororaphis hypothetical protein, needed for nitrile hydratase expression SW:P47K_PSECL (P31521) (419 aa) fasta scores: E(): 1.2e-55, 43.142% id in 401 aa, and to Bacillus subtilis hypothetical protein YciC TR:P94400 (EMBL:D50453) (397 aa) fasta scores: E(): 1.9e-100, 67.424% id in 396 aa; cobalamin synthesis protein 477232 2859555 SAR0450 Staphylococcus aureus subsp. aureus MRSA252 cobalamin synthesis protein YP_039898.1 476030 D 282458 CDS YP_039899.1 49482675 2859556 477501..477629 1 NC_002952.2 hypothetical protein 477629 2859556 SAR0451 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039899.1 477501 D 282458 CDS YP_039900.1 49482676 2859557 478818..480302 1 NC_002952.2 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit 5 480302 2859557 SAR0452 Staphylococcus aureus subsp. aureus MRSA252 NADH dehydrogenase subunit 5 YP_039900.1 478818 D 282458 CDS YP_039901.1 49482677 2859558 480315..483020 1 NC_002952.2 Similar to Aquifex aeolicus hypothetical protein AG_863 TR:O67026 (EMBL:AE000711) (1007 aa) fasta scores: E(): 2.9e-42, 27.685% id in 1015 aa, and an internal region of Bacillus subtilis hypothetical protein YbcD TR:O87092 (EMBL:AB006424) (686 aa) fasta scores: E(): 7.8e-94, 46.501% id in 686 aa; hypothetical protein 483020 2859558 SAR0453 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039901.1 480315 D 282458 CDS YP_039902.1 49482678 2859559 483182..483544 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YbcI TR:O34380 (EMBL:Z99104) (124 aa) fasta scores: E(): 7.6e-32, 70.000% id in 120 aa, and to Bacillus halodurans hypothetical protein BH3870 TR:Q9K662 (EMBL:AP001520) (121 aa) fasta scores: E(): 3.8e-30, 66.387% id in 119 aa; hypothetical protein 483544 2859559 SAR0454 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039902.1 483182 D 282458 CDS YP_039903.1 49482679 2859560 complement(483773..484120) 1 NC_002952.2 Poor database matches. C-terminal region is similar to Staphylococcus aureus hypothetical protein SAV0455 or SA0414 SWALL:Q99WE7 (EMBL:AP003359) (80 aa) fasta scores: E(): 1.7e-29, 98.75% id in 80 aa. Possible alternative translational start site; hypothetical protein 484120 2859560 SAR0455 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039903.1 483773 R 282458 CDS YP_039904.1 49482680 2859561 484227..484901 1 NC_002952.2 Similar to Helicobacter pylori J99 hypothetical protein JHP0787 TR:Q9ZKZ5 (EMBL:AE001509) (228 aa) fasta scores: E(): 6.9e-13, 29.767% id in 215 aa, and to Bacillus megaterium hypothetical protein TR:Q06074 (EMBL:Z21972) (216 aa) fasta scores: E(): 2.1e-10, 26.244% id in 221 aa; hypothetical protein 484901 2859561 SAR0456 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039904.1 484227 D 282458 CDS YP_039905.1 49482681 2859562 484938..485672 1 NC_002952.2 Similar to Bacillus stearothermophilus carboxylesterase precursor Est SW:EST_BACST (Q06174) (247 aa) fasta scores: E(): 1.3e-22, 31.020% id in 245 aa, and to Bacillus subtilis hypothetical protein YvaK TR:O32232 (EMBL:Z99121) (248 aa) fasta scores: E(): 2e-24, 31.837% id in 245 aa; hypothetical protein 485672 2859562 SAR0457 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039905.1 484938 D 282458 CDS YP_039906.1 49482682 2859563 485874..485963 1 NC_002952.2 Doubtful CDS. No database matches; hypothetical protein 485963 2859563 SAR0457a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039906.1 485874 D 282458 CDS YP_039907.1 49482683 2859564 486126..487466 1 NC_002952.2 Similar to Bacillus subtilis transporter YocR TR:O34383 (EMBL:AF027868) (445 aa) fasta scores: E(): 1.8e-73, 49.103% id in 446 aa, and to Bacillus halodurans sodium-dependent transporter BH0217 TR:Q9KG95 (EMBL:AP001507) (457 aa) fasta scores: E(): 1.1e-67, 46.727% id in 443 aa; sodium:neurotransmitter symporter family protein 487466 2859564 SAR0458 Staphylococcus aureus subsp. aureus MRSA252 sodium:neurotransmitter symporter family protein YP_039907.1 486126 D 282458 CDS YP_039908.1 49482684 2859565 487683..488588 1 NC_002952.2 Similar to Bacillus subtilis cysteine synthase YrhA TR:O05393 (EMBL:U93874) (307 aa) fasta scores: E(): 2.4e-51, 51.864% id in 295 aa, and to Helicobacter pylori cysteine synthase HP0107 SW:CYSM_HELPY (P56067) (306 aa) fasta scores: E(): 4.7e-47, 48.993% id in 298 aa; pyridoxal-phosphate dependent protein 488588 2859565 SAR0459 Staphylococcus aureus subsp. aureus MRSA252 pyridoxal-phosphate dependent protein YP_039908.1 487683 D 282458 CDS YP_039909.1 49482685 2859566 488581..489723 1 NC_002952.2 Similar to Bacillus subtilis cystathionine gamma-lyase YrhB TR:O05394 (EMBL:U93874) (379 aa) fasta scores: E(): 7.2e-82, 57.632% id in 380 aa, and to Helicobacter pylori cystathionine gamma-synthase HP0106 SW:METB_HELPY (P56069) (380 aa) fasta scores: E(): 2.3e-76, 53.846% id in 377 aa; Cys/Met metabolism PLP-dependent enzyme 489723 2859566 SAR0460 Staphylococcus aureus subsp. aureus MRSA252 Cys/Met metabolism PLP-dependent enzyme YP_039909.1 488581 D 282458 CDS YP_039910.1 49482686 2859567 490014..491039 1 NC_002952.2 Similar to Escherichia coli probable ATP-binding component of a transporter system Abc SW:ABC_ECOLI (P30750) (343 aa) fasta scores: E(): 1.7e-48, 46.313% id in 339 aa, and to Vibrio cholerae ABC transporter ATP-binding protein VC0907 TR:Q9KTJ5 (EMBL:AE004174) (344 aa) fasta scores: E(): 6.8e-49, 46.313% id in 339 aa; ABC transporter ATP-binding protein 491039 2859567 SAR0461 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_039910.1 490014 D 282458 CDS YP_039911.1 49482687 2859568 491043..491702 1 NC_002952.2 Similar to Salmonella enteritidis pathogenicity islet encoded integral membrane protein SfbC TR:Q9S4Y9 (EMBL:AF102556) (202 aa) fasta scores: E(): 2e-30, 48.969% id in 194 aa, and to Vibrio cholerae ABC transporter, permease VC0906 TR:Q9KTJ6 (EMBL:AE004174) (225 aa) fasta scores: E(): 5.7e-38, 51.659% id in 211 aa. CDS contains extra residues at the N-terminus in comparison to the S. enteritidis protein; transport system membrane protein 491702 2859568 SAR0462 Staphylococcus aureus subsp. aureus MRSA252 transport system membrane protein YP_039911.1 491043 D 282458 CDS YP_039912.1 49482688 2859569 491739..492581 1 NC_002952.2 Similar to Pasteurella haemolytica outer membrane lipoprotein 3 precursor PlpC SW:PLPC_PASHA (Q08870) (263 aa) fasta scores: E(): 1.8e-25, 38.846% id in 260 aa, and to Lactococcus lactis outer membrane lipoprotein precursor PlpB TR:Q9CIN7 (EMBL:AE006269) (286 aa) fasta scores: E(): 7.2e-31, 42.751% id in 269 aa; lipoprotein 492581 2859569 SAR0463 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_039912.1 491739 D 282458 CDS YP_039913.1 49482689 2859570 492915..493919 1 NC_002952.2 Similar to an internal region of Enterococcus faecalis autolysin precursor SW:ALYS_ENTFA (P37710) (671 aa) fasta scores: E(): 2.5e-18, 31.970% id in 269 aa, and to the C-terminal region of Bacillus subtilis endopeptidase precursor LytF TR:O07532 (EMBL:Y14079) (488 aa) fasta scores: E(): 1.4e-20, 34.591% id in 318 aa; hypothetical protein 493919 2859570 SAR0464 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039913.1 492915 D 282458 CDS YP_039914.1 49482690 2859571 complement(494106..494375) 1 NC_002952.2 hypothetical protein 494375 2859571 SAR0465 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039914.1 494106 R 282458 CDS YP_039915.1 49482691 2859572 494516..494920 1 NC_002952.2 Poor database matches. Similar to the N-terminal regions of Pseudomonas aeruginosa hypothetical protein PA3470 TR:Q9HYD6 (EMBL:AE004768) (152 aa) fasta scores: E(): 0.00013, 29.524% id in 105 aa, and to Streptococcus pneumoniae hypothetical protein TR:Q9K2H0 (EMBL:AF154045) (212 aa) fasta scores: E(): 0.0026, 30.275% id in 109 aa; MutT domain-containing protein 494920 2859572 SAR0466 Staphylococcus aureus subsp. aureus MRSA252 MutT domain-containing protein YP_039915.1 494516 D 282458 CDS YP_039916.1 49482692 2859573 494910..495395 1 NC_002952.2 Similar to Bacillus subtilis spermine/spermidine acetyltransferase BltD SW:BLTD_BACSU (P39909) (152 aa) fasta scores: E(): 0.0021, 21.154% id in 156 aa, and to Bacillus halodurans hypothetical protein BH3804 TR:Q9K6C5 (EMBL:AP001520) (167 aa) fasta scores: E(): 2.1e-10, 31.159% id in 138 aa. Possible alternative translational start site; acetyltransferase 495395 2859573 SAR0467 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_039916.1 494910 D 282458 CDS YP_039917.1 49482693 2859574 complement(495564..496346) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YibF TR:Q9CHC4 (EMBL:AE006314) (253 aa) fasta scores: E(): 4.4e-18, 26.172% id in 256 aa, and to an internal region of Streptomyces coelicolor membrane protein SCQ11.10c TR:Q9X9U1 (EMBL:AL096823) (513 aa) fasta scores: E(): 4.7e-14, 25.200% id in 250 aa; hypothetical protein 496346 2859574 SAR0468 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039917.1 495564 R 282458 CDS YP_039918.1 49482694 2859575 complement(496343..497461) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YibE TR:Q9CHC5 (EMBL:AE006314) (393 aa) fasta scores: E(): 3.1e-24, 30.303% id in 363 aa, and to an internal region of Streptomyces coelicolor membrane protein SCQ11.10c TR:Q9X9U1 (EMBL:AL096823) (513 aa) fasta scores: E(): 8.5e-12, 26.102% id in 295 aa; hypothetical protein 497461 2859575 SAR0469 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039918.1 496343 R 282458 CDS YP_039919.1 49482695 2859576 complement(497576..498460) 1 NC_002952.2 Similar to Bacillus subtilis glutamate biosynthesis transcriptional regulatory protein GltC SW:GLTC_BACSU (P20668) (300 aa) fasta scores: E(): 1.3e-14, 29.900% id in 301 aa. N-terminus is similar to the N-terminal region of Acinetobacter calcoaceticus cat operon transcriptional regulator CatM SW:CATM_ACICA (P07774) (303 aa) fasta scores: E(): 5.1e-12, 30.364% id in 247 aa; LysR family regulatory protein 498460 2859576 SAR0470 Staphylococcus aureus subsp. aureus MRSA252 LysR family regulatory protein YP_039919.1 497576 R 282458 CDS YP_039920.1 49482696 2859930 498641..503140 1 NC_002952.2 Similar to Bacillus subtilis glutamate synthase [NADPH], large subunit protein GltB SW:GLTB_BACSU (P39812) (1520 aa) fasta scores: E(): 0, 53.329% id in 1517 aa, and to Campylobacter jejuni glutamate synthase GltB TR:Q9PJA4 (EMBL:AL139074) (1496 aa) fasta scores: E(): 0, 47.641% id in 1505 aa; glutamate synthase 503140 gltA 2859930 gltA Staphylococcus aureus subsp. aureus MRSA252 glutamate synthase YP_039920.1 498641 D 282458 CDS YP_039921.1 49482697 2859931 503158..504621 1 NC_002952.2 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase 504621 gltD 2859931 gltD Staphylococcus aureus subsp. aureus MRSA252 glutamate synthase YP_039921.1 503158 D 282458 CDS YP_039922.1 49482698 2859577 505439..506866 1 NC_002952.2 Similar to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SW:PTSB_STAXY (P51184) (480 aa) fasta scores: E(): 1.5e-74, 46.653% id in 478 aa, and to Bacillus halodurans PTS system, trehalose-specific enzyme IIBC component BH2216 TR:Q9KAS1 (EMBL:AP001514) (470 aa) fasta scores: E(): 8.2e-91, 54.873% id in 472 aa; sugar-specific PTS transport system, IIBC component 506866 2859577 SAR0473 Staphylococcus aureus subsp. aureus MRSA252 sugar-specific PTS transport system, IIBC component YP_039922.1 505439 D 282458 CDS YP_039923.1 49482699 2859578 506930..508570 1 NC_002952.2 Similar to Bacillus subtilis trehalose-6-phosphate hydrolase TreA SW:TREC_BACSU (P39795) (561 aa) fasta scores: E(): 1.8e-132, 59.538% id in 519 aa, and to Escherichia coli trehalose-6-phosphate hydrolase TreC SW:TREC_ECOLI (P28904) (551 aa) fasta scores: E(): 1.5e-119, 56.660% id in 503 aa; glycosyl hydrolase 508570 2859578 SAR0474 Staphylococcus aureus subsp. aureus MRSA252 glycosyl hydrolase YP_039923.1 506930 D 282458 CDS YP_039924.1 49482700 2859579 508595..509323 1 NC_002952.2 Similar to Bacillus subtilis trehalose operon transcriptional repressor TreR SW:TRER_BACSU (P39796) (238 aa) fasta scores: E(): 4e-26, 39.076% id in 238 aa, and to Bacillus halodurans trehalose operon transcriptional repressor TreR TR:Q9KEH9 (EMBL:AP001510) (237 aa) fasta scores: E(): 2e-26, 38.889% id in 234 aa; GntR family transcriptional regulator 509323 2859579 SAR0475 Staphylococcus aureus subsp. aureus MRSA252 GntR family transcriptional regulator YP_039924.1 508595 D 282458 CDS YP_039926.1 49482702 2859581 509964..510488 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YafC TR:Q9CJE1 (EMBL:AE006244) (173 aa) fasta scores: E(): 9.5e-11, 28.902% id in 173 aa, and to Escherichia coli hypothetical protein YhbS SW:YHBS_ECOLI (P45473) (167 aa) fasta scores: E(): 4.1e-05, 27.972% id in 143 aa; acetyltransferase (GNAT) family protein 510488 2859581 SAR0476 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_039926.1 509964 D 282458 CDS YP_039927.1 49482703 2859606 510557..512254 1 NC_002952.2 N-terminus is similar to the N-terminal region of Escherichia coli DNA polymerase III, tau subunit protein DnaX SW:DP3X_ECOLI (P06710) (643 aa) fasta scores: E(): 8.3e-40, 36.404% id in 456 aa. Full length CDS is similar to Bacillus subtilis DNA polymerase III subunit gamma/tau DnaX SW:DP3X_BACSU (P09122) (563 aa) fasta scores: E(): 4e-80, 46.034% id in 580 aa; DNA polymerase III, tau subunit 512254 dnaX 2859606 dnaX Staphylococcus aureus subsp. aureus MRSA252 DNA polymerase III, tau subunit YP_039927.1 510557 D 282458 CDS YP_039928.1 49482704 2859582 512344..512661 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YaaK SW:YAAK_BACSU (P24281) (107 aa) fasta scores: E(): 1.9e-22, 66.981% id in 106 aa, and to Bacillus halodurans hypothetical protein BH0035 SW:Y035_BACHD (Q9JWQ5) (103 aa) fasta scores: E(): 1.2e-20, 64.000% id in 100 aa; hypothetical protein 512661 2859582 SAR0478 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039928.1 512344 D 282458 CDS YP_039929.1 49482705 2859303 512668..513264 1 NC_002952.2 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 513264 recR 2859303 recR Staphylococcus aureus subsp. aureus MRSA252 recombination protein RecR YP_039929.1 512668 D 282458 CDS YP_039930.1 49482706 2859583 complement(519424..520212) 1 NC_002952.2 Similar to C-terminal region of Enterococcus faecium transposase TR:Q47815 (EMBL:L40841) (310 aa) fasta scores: E(): 1.9e-39, 46.183% id in 262 aa, and to the full length Neisseria gonorrhoeae hypothetical protein TR:Q50996 (EMBL:L36381) (267 aa) fasta scores: E(): 1.1e-27, 39.689% id in 257 aa; insertion element protein 520212 2859583 SAR0480 Staphylococcus aureus subsp. aureus MRSA252 insertion element protein YP_039930.1 519424 R 282458 CDS YP_039931.1 49482707 2859584 complement(520236..520991) 1 NC_002952.2 C-terminal is similar to Lactobacillus johnsonii insertion element IS1223 hypothetical protein SW:YI3A_LACJO (Q48585) (177 aa) fasta scores: E(): 2.7e-08, 33.140% id in 172 aa, and Lactococcus lactis hypothetical protein YgcE TR:O32786 (EMBL:X92946) (185 aa) fasta scores: E(): 7.2e-06, 26.404% id in 178 aa. Possible alternative translational start site; insertion element protein 520991 2859584 SAR0481 Staphylococcus aureus subsp. aureus MRSA252 insertion element protein YP_039931.1 520236 R 282458 CDS YP_039932.1 49482708 2859585 521423..522760 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YaaO SW:YAAO_BACSU (P37536) (480 aa) fasta scores: E(): 3.4e-27, 35.908% id in 479 aa, and to Bacillus halodurans lysine decarboxylase BH0041 TR:Q9KGM0 (EMBL:AP001507) (482 aa) fasta scores: E(): 2.4e-21, 33.766% id in 462 aa; Orn/Lys/Arg decarboxylase 522760 2859585 SAR0482 Staphylococcus aureus subsp. aureus MRSA252 Orn/Lys/Arg decarboxylase YP_039932.1 521423 D 282458 CDS YP_039933.1 49482709 2859535 522762..523379 1 NC_002952.2 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 523379 tmk 2859535 tmk Staphylococcus aureus subsp. aureus MRSA252 thymidylate kinase YP_039933.1 522762 D 282458 CDS YP_039934.1 49482710 2859586 523407..523736 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0043 TR:Q9KGL8 (EMBL:AP001507) (109 aa) fasta scores: E(): 8e-29, 66.055% id in 109 aa, and to Bacillus subtilis hypothetical protein YaaQ SW:YAAQ_BACSU (P37538) (109 aa) fasta scores: E(): 9.7e-28, 65.138% id in 109 aa; hypothetical protein 523736 2859586 SAR0484 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039934.1 523407 D 282458 CDS YP_039935.1 49482711 2859644 523950..524876 1 NC_002952.2 Similar to Bacillus subtilis DNA polymerase III, delta' subunit protein HolB SW:HOLB_BACSU (P37540) (329 aa) fasta scores: E(): 3.3e-25, 31.699% id in 306 aa, and to Bacillus halodurans DNA polymerase III delta' subunit HolB TR:Q9KGL7 (EMBL:AP001507) (328 aa) fasta scores: E(): 9.1e-23, 30.421% id in 309 aa; DNA polymerase III subunit delta' 524876 holB 2859644 holB Staphylococcus aureus subsp. aureus MRSA252 DNA polymerase III subunit delta' YP_039935.1 523950 D 282458 CDS YP_039936.1 49482712 2859587 524877..525680 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YaaT SW:YAAT_BACSU (P37541) (275 aa) fasta scores: E(): 1.7e-62, 63.019% id in 265 aa, and to Bacillus halodurans signal peptidase-like protein BH0045 TR:Q9KGL6 (EMBL:AP001507) (275 aa) fasta scores: E(): 7.6e-60, 59.696% id in 263 aa; hypothetical protein 525680 2859587 SAR0486 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039936.1 524877 D 282458 CDS YP_039937.1 49482713 2859456 525697..526044 1 NC_002952.2 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 526044 2859456 SAR0487 Staphylococcus aureus subsp. aureus MRSA252 DNA replication intiation control protein YabA YP_039937.1 525697 D 282458 CDS YP_039938.1 49482714 2859457 526318..527043 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YabB SW:YABB_BACSU (P37543) (247 aa) fasta scores: E(): 2.1e-42, 46.281% id in 242 aa, and to Streptococcus pyogenes hypothetical protein SPY1411 TR:Q99Z41 (EMBL:AE006578) (258 aa) fasta scores: E(): 4.2e-37, 41.803% id in 244 aa; hypothetical protein 527043 2859457 SAR0488 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039938.1 526318 D 282458 CDS YP_039939.1 49482715 2859458 527036..527284 1 NC_002952.2 Similar to Halobacterium sp hypothetical protein VNG2274C TR:Q9HN31 (EMBL:AE005112) (77 aa) fasta scores: E(): 1.5e-13, 54.167% id in 72 aa, and to Bacillus subtilis hypothetical protein YazA TR:O31414 (EMBL:Z99104) (99 aa) fasta scores: E(): 4.3e-15, 53.086% id in 81 aa; hypothetical protein 527284 2859458 SAR0489 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039939.1 527036 D 282458 CDS YP_039940.1 49482716 2859459 527286..528125 1 NC_002952.2 Similar to Bacillus halodurans BH0049 TR:Q9KGL2 (EMBL:AP001507) (289 aa) fasta scores: E(): 2.1e-45, 49.638% id in 276 aa, and to Bacillus subtilis hypothetical protein YabC SW:YABC_BACSU (P37544) (292 aa) fasta scores: E(): 3.3e-43, 46.595% id in 279 aa; tetrapyrrole (corrin/porphyrin) methylase 528125 2859459 SAR0490 Staphylococcus aureus subsp. aureus MRSA252 tetrapyrrole (corrin/porphyrin) methylase YP_039940.1 527286 D 282458 CDS YP_039941.1 49482717 2861163 528410..530383 1 NC_002952.2 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 530383 metG 2861163 metG Staphylococcus aureus subsp. aureus MRSA252 methionyl-tRNA synthetase YP_039941.1 528410 D 282458 CDS YP_039942.1 49482718 2859460 530414..531187 1 NC_002952.2 Similar to Bacillus subtilis deoxyribonuclease YabD SW:YABD_BACSU (P37545) (255 aa) fasta scores: E(): 1.4e-65, 65.625% id in 256 aa, and to Vibrio cholerae hypothetical protein VC2014 TR:Q9KQI4 (EMBL:AE004276) (255 aa) fasta scores: E(): 4.8e-36, 42.802% id in 257 aa; TatD related DNase 531187 2859460 SAR0492 Staphylococcus aureus subsp. aureus MRSA252 TatD related DNase YP_039942.1 530414 D 282458 CDS YP_039943.1 49482719 2859461 531354..531890 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YabF SW:YABF_BACSU (P37547) (186 aa) fasta scores: E(): 2.8e-27, 52.809% id in 178 aa, and to Streptococcus pyogenes hypothetical protein SPY0261 TR:Q9A1I1 (EMBL:AE006492) (189 aa) fasta scores: E(): 1.5e-26, 48.619% id in 181 aa; hypothetical protein 531890 2859461 SAR0493 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039943.1 531354 D 282458 CDS YP_039944.1 49482720 2859462 531901..532794 1 NC_002952.2 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 532794 ksgA 2859462 ksgA Staphylococcus aureus subsp. aureus MRSA252 dimethyladenosine transferase YP_039944.1 531901 D 282458 CDS YP_039945.1 49482721 2860427 532894..533157 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein Veg SW:VEG_BACSU (P37466) (86 aa) fasta scores: E(): 2.3e-18, 62.025% id in 79 aa, and to Bacillus halodurans hypothetical protein BH0059 TR:Q9KGK2 (EMBL:AP001507) (88 aa) fasta scores: E(): 1.4e-17, 58.750% id in 80 aa; hypothetical protein 533157 veg 2860427 veg Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039945.1 532894 D 282458 CDS YP_039946.1 49482722 2859463 533468..534316 1 NC_002952.2 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 534316 ipk 2859463 ipk Staphylococcus aureus subsp. aureus MRSA252 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_039946.1 533468 D 282458 CDS YP_039947.1 49482723 2859553 534330..535154 1 NC_002952.2 Similar to Bacillus subtilis pur operon repressor PurR SW:PURR_BACSU (P37551) (285 aa) fasta scores: E(): 1.5e-54, 54.212% id in 273 aa, and to Bacillus halodurans purine operon repressor PurR TR:Q9KGJ9 (EMBL:AP001507) (282 aa) fasta scores: E(): 1.4e-49, 49.814% id in 269 aa; pur operon repressor 535154 purR 2859553 purR Staphylococcus aureus subsp. aureus MRSA252 pur operon repressor YP_039947.1 534330 D 282458 CDS YP_039948.1 49482724 2860434 535171..535551 1 NC_002952.2 Similar to Bacillus subtilis regulator of purine biosynthesis YabJ SW:YABJ_BACSU (P37552) (124 aa) fasta scores: E(): 3.8e-25, 58.537% id in 123 aa, and to Bacillus halodurans translation initiation inhibitor BH0063 TR:Q9KGJ8 (EMBL:AP001507) (124 aa) fasta scores: E(): 2.1e-27, 62.097% id in 124 aa; regulatory protein 535551 yabJ 2860434 yabJ Staphylococcus aureus subsp. aureus MRSA252 regulatory protein YP_039948.1 535171 D 282458 CDS YP_039949.1 49482725 2859158 535624..535926 1 NC_002952.2 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus; regulatory protein SpoVG 535926 spoVG 2859158 spoVG Staphylococcus aureus subsp. aureus MRSA252 regulatory protein SpoVG YP_039949.1 535624 D 282458 CDS YP_039950.1 49482726 2860694 536269..537621 1 NC_002952.2 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 537621 glmU 2860694 glmU Staphylococcus aureus subsp. aureus MRSA252 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_039950.1 536269 D 282458 CDS YP_039951.1 49482727 2860154 537768..538733 1 NC_002952.2 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 538733 prs 2860154 prs Staphylococcus aureus subsp. aureus MRSA252 ribose-phosphate pyrophosphokinase YP_039951.1 537768 D 282458 CDS YP_039952.1 49482728 2860920 538883..539536 1 NC_002952.2 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc 539536 rplY 2860920 rplY Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L25/general stress protein Ctc YP_039952.1 538883 D 282458 CDS YP_039953.1 49482729 2860453 539847..540419 1 NC_002952.2 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 540419 2860453 SAR0503 Staphylococcus aureus subsp. aureus MRSA252 peptidyl-tRNA hydrolase YP_039953.1 539847 D 282458 CDS YP_039954.1 49482730 2861065 540419..543925 1 NC_002952.2 Similar to Escherichia coli transcription-repair coupling factor Mfd SW:MFD_ECOLI (P30958) (1148 aa) fasta scores: E(): 2.1e-119, 37.169% id in 1095 aa, and to Bacillus subtilis transcription-repair coupling factor Mfd SW:MFD_BACSU (P37474) (1177 aa) fasta scores: E(): 1.2e-211, 49.490% id in 1176 aa; transcription-repair coupling factor 543925 2861065 SAR0504 Staphylococcus aureus subsp. aureus MRSA252 transcription-repair coupling factor YP_039954.1 540419 D 282458 CDS YP_039955.1 49482731 2861066 543915..545441 1 NC_002952.2 Similar to Bacillus subtilis stage V sporulation protein B SpoVB SW:SP5B_BACSU (Q00758) (518 aa) fasta scores: E(): 4.8e-14, 23.819% id in 529 aa, and to Bacillus halodurans hypothetical protein BH0071 TR:Q9KGJ0 (EMBL:AP001507) (533 aa) fasta scores: E(): 3.2e-33, 30.906% id in 508 aa; polysaccharide biosynthesis protein 545441 2861066 SAR0505 Staphylococcus aureus subsp. aureus MRSA252 polysaccharide biosynthesis protein YP_039955.1 543915 D 282458 CDS YP_039956.1 49482732 2861067 545441..546634 1 NC_002952.2 N-terminus is similar to N-terminal regions of Bacillus halodurans hypothetical protein BH0072 TR:Q9KGI9 (EMBL:AP001507) (491 aa) fasta scores: E(): 3.8e-63, 49.435% id in 354 aa, and Bacillus subtilis hypothetical protein YabN SW:YABN_BACSU (P37556) (489 aa) fasta scores: E(): 2e-62, 50.282% id in 354 aa; tetrapyrrole (corrin/porphyrin) methylase 546634 2861067 SAR0506 Staphylococcus aureus subsp. aureus MRSA252 tetrapyrrole (corrin/porphyrin) methylase YP_039956.1 545441 D 282458 CDS YP_039957.1 49482733 2861068 546631..546894 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YabO SW:YABO_BACSU (P37557) (86 aa) fasta scores: E(): 1.8e-18, 68.605% id in 86 aa, and to Bacillus halodurans hypothetical protein BH0073 TR:Q9KGI8 (EMBL:AP001507) (88 aa) fasta scores: E(): 5.9e-17, 67.901% id in 81 aa; S4 domain-containing protein 546894 2861068 SAR0507 Staphylococcus aureus subsp. aureus MRSA252 S4 domain-containing protein YP_039957.1 546631 D 282458 CDS YP_039958.1 49482734 2861069 546912..547304 1 NC_002952.2 Similar to Bacillus subtilis cell division protein DivIC SW:DIVC_BACSU (P37471) (125 aa) fasta scores: E(): 5.8e-06, 32.743% id in 113 aa, and to Listeria monocytogenes DivIC homolog DivL TR:Q9ZIM0 (EMBL:AF023181) (128 aa) fasta scores: E(): 2.5e-07, 37.097% id in 124 aa; cell division protein 547304 2861069 SAR0508 Staphylococcus aureus subsp. aureus MRSA252 cell division protein YP_039958.1 546912 D 282458 CDS YP_039959.1 49482735 2861070 547409..547810 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YabR SW:YABR_BACSU (P37560) (128 aa) fasta scores: E(): 3.4e-26, 63.433% id in 134 aa. N-terminal region is similar to the C-terminus of Escherichia coli polyribonucleotide nucleotidyltransferase Pnp SW:PNP_ECOLI (P05055) (711 aa) fasta scores: E(): 8.1e-08, 48.485% id in 99 aa; hypothetical protein 547810 2861070 SAR0509 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039959.1 547409 D 282458 CDS YP_039960.1 49482736 2861071 547990..549285 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YacA SW:YACA_BACSU (P37563) (472 aa) fasta scores: E(): 1e-15, 27.740% id in 447 aa, and to Buchnera aphidicola (subsp. Acyrthosiphon pisum) cell cycle protein BU110 SW:MESJ_BUCAI (P57211) (440 aa) fasta scores: E(): 2.5e-16, 25.120% id in 418 aa; hypothetical protein 549285 2861071 SAR0510 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039960.1 547990 D 282458 CDS YP_039961.1 49482737 2859646 549290..549829 1 NC_002952.2 Similar to Vibrio harveyi hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_VIBHA (P18134) (176 aa) fasta scores: E(): 4e-28, 50.000% id in 170 aa, and to Bacillus subtilis hypoxanthine-guanine phosphoribosyltransferase HprT SW:HPRT_BACSU (P37472) (180 aa) fasta scores: E(): 1.6e-37, 60.452% id in 177 aa; hypoxanthine phosphoribosyltransferase 549829 hpt 2859646 hpt Staphylococcus aureus subsp. aureus MRSA252 hypoxanthine phosphoribosyltransferase YP_039961.1 549290 D 282458 CDS YP_039962.1 49482738 2860684 550087..552180 1 NC_002952.2 Similar to Bacillus firmus cell division protein FtsH homologue FtsH SW:FTSH_BACFI (P94304) (679 aa) fasta scores: E(): 8.4e-133, 61.437% id in 682 aa, and to Bacillus subtilis cell division protein FtsH homologue FtsH SW:FTSH_BACSU (P37476) (637 aa) fasta scores: E(): 4.1e-135, 66.984% id in 630 aa; cell division protein 552180 ftsH 2860684 ftsH Staphylococcus aureus subsp. aureus MRSA252 cell division protein YP_039962.1 550087 D 282458 CDS YP_039963.1 49482739 2861072 552594..553475 1 NC_002952.2 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 553475 hslO 2861072 hslO Staphylococcus aureus subsp. aureus MRSA252 Hsp33-like chaperonin YP_039963.1 552594 D 282458 CDS YP_039964.1 49482740 2861073 553654..554586 1 NC_002952.2 Similar to Methanosarcina barkeri O-acetylserine CysK TR:Q9UWP0 (EMBL:AF174138) (308 aa) fasta scores: E(): 2.4e-61, 60.927% id in 302 aa, and to Bacillus subtilis cysteine synthase CysK SW:CYSK_BACSU (P37887) (307 aa) fasta scores: E(): 1.1e-76, 69.307% id in 303 aa; O-acetylserine (thiol)-lyase 554586 2861073 SAR0514 Staphylococcus aureus subsp. aureus MRSA252 O-acetylserine (thiol)-lyase YP_039964.1 553654 D 282458 CDS YP_039965.1 49482741 2860679 554802..555605 1 NC_002952.2 Previously sequenced as Staphylococcus aureus dihydropteroate synthase FolP SW:DHPS_STAAU (O05701) (267 aa) fasta scores: E(): 9.5e-100, 100.000% id in 267 aa. Similar to Staphylococcus haemolyticus dihydropteroate synthase FolP SW:DHPS_STAHA (Q59919) (267 aa) fasta scores: E(): 3.5e-76, 74.157% id in 267 aa; dihydropteroate synthase 555605 folP 2860679 folP Staphylococcus aureus subsp. aureus MRSA252 dihydropteroate synthase YP_039965.1 554802 D 282458 CDS YP_039966.1 49482742 2860675 555583..555948 1 NC_002952.2 Previously sequenced as Staphylococcus aureus dihydroneopterin aldolase FolB SW:FOLB_STAAU (P56740) (121 aa) fasta scores: E(): 7.2e-44, 100.000% id in 121 aa. Similar to Bacillus subtilis dihydroneopterin aldolase FolB SW:FOLB_BACSU (P28823) (120 aa) fasta scores: E(): 1.8e-19, 47.863% id in 117 aa; dihydroneopterin aldolase 555948 folB 2860675 folB Staphylococcus aureus subsp. aureus MRSA252 dihydroneopterin aldolase YP_039966.1 555583 D 282458 CDS YP_039967.1 49482743 2860678 555945..556421 1 NC_002952.2 Similar to Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK SW:HPPK_ECOLI (P26281) (158 aa) fasta scores: E(): 2e-18, 41.429% id in 140 aa, and to Bacillus subtilis 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK SW:HPPK_BACSU (P29252) (167 aa) fasta scores: E(): 9.9e-25, 53.030% id in 132 aa; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 556421 folK 2860678 folK Staphylococcus aureus subsp. aureus MRSA252 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_039967.1 555945 D 282458 CDS YP_039968.1 49482744 2859815 556960..558447 1 NC_002952.2 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 558447 lysS 2859815 lysS Staphylococcus aureus subsp. aureus MRSA252 lysyl-tRNA synthetase YP_039968.1 556960 D 282458 CDS YP_039969.1 49482745 2861074 complement(565186..565974) 1 NC_002952.2 Similar to C-terminal region of Enterococcus faecium transposase TR:Q47815 (EMBL:L40841) (310 aa) fasta scores: E(): 1.9e-39, 46.183% id in 262 aa, and to the full length Neisseria gonorrhoeae hypothetical protein TR:Q50996 (EMBL:L36381) (267 aa) fasta scores: E(): 1.1e-27, 39.689% id in 257 aa; insertion element protein 565974 2861074 SAR0519 Staphylococcus aureus subsp. aureus MRSA252 insertion element protein YP_039969.1 565186 R 282458 CDS YP_039970.1 49482746 2861075 complement(565998..566753) 1 NC_002952.2 C-terminal region is similar to Lactobacillus johnsonii insertion element IS1223 hypothetical protein SW:YI3A_LACJO (Q48585) (177 aa) fasta scores: E(): 2.9e-08, 33.526% id in 173 aa, and Lactococcus lactis hypothetical protein YgcE TR:O32786 (EMBL:X92946) (185 aa) fasta scores: E(): 4.8e-06, 26.404% id in 178 aa. Possible alternative translational start site; insertion element protein 566753 2861075 SAR0520 Staphylococcus aureus subsp. aureus MRSA252 insertion element protein YP_039970.1 565998 R 282458 CDS YP_039971.1 49482747 2861076 complement(567324..568706) 1 NC_002952.2 Similar to Rhizobium leguminosarum regulatory protein MocR TR:O85775 (EMBL:AF076240) (488 aa) fasta scores: E(): 2.7e-35, 30.297% id in 472 aa, and to Bacillus subtilis regulatory protein YdeL TR:P96669 (EMBL:AB001488) (463 aa) fasta scores: E(): 8.7e-54, 36.364% id in 451 aa; GntR family transcriptional regulator 568706 2861076 SAR0521 Staphylococcus aureus subsp. aureus MRSA252 GntR family transcriptional regulator YP_039971.1 567324 R 282458 CDS YP_039972.1 49482748 2861077 568810..569697 1 NC_002952.2 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 569697 2861077 SAR0522 Staphylococcus aureus subsp. aureus MRSA252 pyridoxal biosynthesis lyase PdxS YP_039972.1 568810 D 282458 CDS YP_039973.1 49482749 2861078 569701..570261 1 NC_002952.2 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 570261 2861078 SAR0523 Staphylococcus aureus subsp. aureus MRSA252 glutamine amidotransferase subunit PdxT YP_039973.1 569701 D 282458 CDS YP_039974.1 49482750 2859170 complement(570468..571682) 1 NC_002952.2 Similar to Escherichia coli nucleoside permease NupC SW:NUPC_ECOLI (P33031) (400 aa) fasta scores: E(): 8.4e-72, 54.208% id in 404 aa, and to Bacillus subtilis pyrimidine nucleoside transport protein NupC SW:NUPC_BACSU (P39141) (393 aa) fasta scores: E(): 3.2e-59, 63.275% id in 403 aa; nucleoside permease 571682 nupC 2859170 nupC Staphylococcus aureus subsp. aureus MRSA252 nucleoside permease YP_039974.1 570468 R 282458 CDS YP_039975.1 49482751 2861079 571840..572301 1 NC_002952.2 Similar to Bacillus subtilis transcriptional regulator CtsR SW:CTSR_BACSU (P37568) (154 aa) fasta scores: E(): 4.6e-25, 50.685% id in 146 aa, and to Bacillus halodurans transcriptional regulator CtsR TR:Q9JWR8 (EMBL:AP001507) (156 aa) fasta scores: E(): 2.7e-24, 48.026% id in 152 aa; DNA-binding protein 572301 2861079 SAR0525 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_039975.1 571840 D 282458 CDS YP_039976.1 49482752 2861080 572320..572886 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein YacH TR:Q9JWP8 (EMBL:AP001507) (177 aa) fasta scores: E(): 1.5e-10, 32.203% id in 177 aa, and to Bacillus subtilis hypothetical protein YacH SW:YACH_BACSU (P37569) (185 aa) fasta scores: E(): 3.7e-11, 27.222% id in 180 aa; hypothetical protein 572886 2861080 SAR0526 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039976.1 572320 D 282458 CDS YP_039977.1 49482753 2861081 572876..573883 1 NC_002952.2 N-terminus is similar to the C-terminal region of Penaeus japonicus arginine kinase SW:KARG_PENJP (P51545) (355 aa) fasta scores: E(): 1.5e-12, 26.66% id in 255 aa. Similar to Bacillus subtilis hypothetical ATP:guanido phosphotransferase YacI SW:YACI_BACSU (P37570) (363 aa) fasta scores: E(): 9.6e-48, 42.81% id in 341 aa; ATP:guanido phosphotransferase 573883 2861081 SAR0527 Staphylococcus aureus subsp. aureus MRSA252 ATP:guanido phosphotransferase YP_039977.1 572876 D 282458 CDS YP_039978.1 49482754 2859234 573897..576353 1 NC_002952.2 Similar to Bacillus subtilis negative regulator of genetic competence ClpC SW:CLPC_BACSU (P37571) (810 aa) fasta scores: E(): 2.7e-189, 69.753% id in 810 aa, and to Bacillus halodurans class III stress response-related ATPase ClpC TR:Q9KGG2 (EMBL:AP001507) (813 aa) fasta scores: E(): 1.3e-189, 70.237% id in 803 aa; stress response-related Clp ATPase 576353 clpC 2859234 clpC Staphylococcus aureus subsp. aureus MRSA252 stress response-related Clp ATPase YP_039978.1 573897 D 282458 CDS YP_039979.1 49482755 2859297 576837..578201 1 NC_002952.2 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 578201 radA 2859297 radA Staphylococcus aureus subsp. aureus MRSA252 DNA repair protein RadA YP_039979.1 576837 D 282458 CDS YP_039980.1 49482756 2861082 578226..579299 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0106 TR:Q9KGF9 (EMBL:AP001507) (362 aa) fasta scores: E(): 5.3e-47, 39.718% id in 355 aa, and to Listeria monocytogenes hypothetical protein SW:YOR6_LISMO (Q48762) (357 aa) fasta scores: E(): 2.8e-42, 36.752% id in 351 aa; hypothetical protein 579299 2861082 SAR0530 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039980.1 578226 D 282458 CDS YP_039981.1 49482757 2859933 579856..581310 1 NC_002952.2 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 581310 gltX 2859933 gltX Staphylococcus aureus subsp. aureus MRSA252 glutamyl-tRNA synthetase YP_039981.1 579856 D 282458 CDS YP_039982.1 49482758 2859256 581734..582381 1 NC_002952.2 Similar to Staphylococcus xylosus serine acetyltransferase CysE SW:CYSE_STAXY (P77985) (216 aa) fasta scores: E(): 1.1e-71, 87.324% id in 213 aa, and to Bacillus halodurans serine O-acetyltransferase CysE TR:Q9KGF5 (EMBL:AP001507) (229 aa) fasta scores: E(): 1.3e-49, 64.115% id in 209 aa. Possible alternative translational start site; serine acetyltransferase 582381 cysE 2859256 cysE Staphylococcus aureus subsp. aureus MRSA252 serine acetyltransferase YP_039982.1 581734 D 282458 CDS YP_039983.1 49482759 2859258 582365..583765 1 NC_002952.2 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 583765 cysS 2859258 cysS Staphylococcus aureus subsp. aureus MRSA252 cysteinyl-tRNA synthetase YP_039983.1 582365 D 282458 CDS YP_039984.1 49482760 2861083 583758..584162 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YazC TR:O31418 (EMBL:Z99104) (143 aa) fasta scores: E(): 1.6e-21, 55.118% id in 127 aa, and to Streptococcus pyogenes hypothetical protein SPY1940 TR:Q99Y00 (EMBL:AE006617) (137 aa) fasta scores: E(): 6.5e-19, 44.444% id in 126 aa; hypothetical protein 584162 2861083 SAR0534 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039984.1 583758 D 282458 CDS YP_039985.1 49482761 2859627 584170..584916 1 NC_002952.2 Previously sequenced as Staphylococcus aureus rRNA methylase YacO TR:Q9AGT0 (EMBL:AF327733) (248 aa) fasta scores: E(): 6.7e-90, 99.194% id in 248 aa. Similar to Bacillus halodurans tRNA/rRNA methyltransferase BH0113 TR:Q9KGF2 (EMBL:AP001507) (249 aa) fasta scores: E(): 4.5e-51, 58.678% id in 242 aa; SpoU rRNA methylase 584916 yacO 2859627 yacO Staphylococcus aureus subsp. aureus MRSA252 SpoU rRNA methylase YP_039985.1 584170 D 282458 CDS YP_039986.1 49482762 2861084 584916..585440 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YacP SW:YACP_BACSU (P37574) (170 aa) fasta scores: E(): 1.3e-19, 44.242% id in 165 aa, and to Bacillus halodurans hypothetical protein BH0114 TR:Q9KGF1 (EMBL:AP001507) (170 aa) fasta scores: E(): 1.5e-18, 42.941% id in 170 aa; hypothetical protein 585440 2861084 SAR0536 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039986.1 584916 D 282458 CDS YP_039987.1 49482763 2859144 585521..586090 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical protein SigH TR:Q9AGS8 (EMBL:AF327733) (162 aa) fasta scores: E(): 4.1e-59, 98.148% id in 162 aa. Similar to Clostridium difficile hypothetical protein TcdD TR:Q9EXR1 (EMBL:AJ011301) (184 aa) fasta scores: E(): 0.027, 21.547% id in 181 aa; hypothetical protein 586090 sigH 2859144 sigH Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039987.1 585521 D 282458 CDS YP_039988.1 49482764 2860164 586205..586348 1 NC_002952.2 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 586348 rpmG 2860164 rpmG Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L33 YP_039988.1 586205 D 282458 CDS YP_039989.1 49482765 2859134 586404..586586 1 NC_002952.2 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 586586 secE 2859134 secE Staphylococcus aureus subsp. aureus MRSA252 preprotein translocase subunit SecE YP_039989.1 586404 D 282458 CDS YP_039990.1 49482766 2859172 586599..587147 1 NC_002952.2 Similar to Escherichia coli transcription antitermination protein NusG SW:NUSG_ECOLI (P16921) (181 aa) fasta scores: E(): 7.9e-25, 40.884% id in 181 aa. Previously sequenced as Staphylococcus aureus transcription antitermination protein NusG SW:NUSG_STAAU (O08386) (182 aa) fasta scores: E(): 3.7e-67, 100.000% id in 182 aa; transcription antitermination protein 587147 nusG 2859172 nusG Staphylococcus aureus subsp. aureus MRSA252 transcription antitermination protein YP_039990.1 586599 D 282458 CDS YP_039991.1 49482767 2860906 587328..587750 1 NC_002952.2 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 587750 rplK 2860906 rplK Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L11 YP_039991.1 587328 D 282458 CDS YP_039992.1 49482768 2860898 587958..588647 1 NC_002952.2 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 588647 rplA 2860898 rplA Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L1 YP_039992.1 587958 D 282458 CDS YP_039993.1 49482769 2860905 588922..589422 1 NC_002952.2 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 589422 rplJ 2860905 rplJ Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L10 YP_039993.1 588922 D 282458 CDS YP_039994.1 49482770 2860907 589465..589833 1 NC_002952.2 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 589833 rplL 2860907 rplL Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L7/L12 YP_039994.1 589465 D 282458 CDS YP_039995.1 49482771 2861085 590008..590616 1 NC_002952.2 Similar to the C-terminal region of Escherichia coli ribosomal RNA small subunit methyltransferase C RsmC SW:RSMC_ECOLI (P39406) (342 aa) fasta scores: E(): 1.6e-09, 31.579% id in 171 aa. Full length CDS is similar to Bacillus subtilis hypothetical protein YbxB SW:YBXB_BACSU (P37872) (201 aa) fasta scores: E(): 2.7e-31, 49.500% id in 200 aa; hypothetical protein 590616 2861085 SAR0546 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_039995.1 590008 D 282458 CDS YP_039996.1 49482772 2860169 590831..594382 1 NC_002952.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 594382 rpoB 2860169 rpoB Staphylococcus aureus subsp. aureus MRSA252 DNA-directed RNA polymerase subunit beta YP_039996.1 590831 D 282458 CDS YP_039997.1 49482773 2860170 594519..598142 1 NC_002952.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 598142 rpoC 2860170 rpoC Staphylococcus aureus subsp. aureus MRSA252 DNA-directed RNA polymerase subunit beta' YP_039997.1 594519 D 282458 CDS YP_039998.1 49482774 2861086 598222..598533 1 NC_002952.2 in Bacillus subtilis this non-essential protein associates with the ribosome; ribosomal protein L7Ae-like 598533 2861086 SAR0549 Staphylococcus aureus subsp. aureus MRSA252 ribosomal protein L7Ae-like YP_039998.1 598222 D 282458 CDS YP_039999.1 49482775 2861448 598631..599044 1 NC_002952.2 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 599044 rpsL 2861448 rpsL Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S12 YP_039999.1 598631 D 282458 CDS YP_040000.1 49482776 2860178 599110..599580 1 NC_002952.2 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 599580 rpsG 2860178 rpsG Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S7 YP_040000.1 599110 D 282458 CDS YP_040001.1 49482777 2860687 599703..601784 1 NC_002952.2 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 601784 fus 2860687 fus Staphylococcus aureus subsp. aureus MRSA252 elongation factor G YP_040001.1 599703 D 282458 CDS YP_040002.1 49482778 2860408 602001..603185 1 NC_002952.2 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 603185 tuf 2860408 tuf Staphylococcus aureus subsp. aureus MRSA252 elongation factor Tu YP_040002.1 602001 D 282458 CDS YP_040003.1 49482779 2861087 complement(603466..604641) 1 NC_002952.2 Similar to Arabidopsis thaliana indole-3-acetic acid-amino acid hydrolase 3 precursor protein IAR3 SW:ILR3_ARATH (P54969) (438 aa) fasta scores: E(): 3.8e-46, 37.435% id in 382 aa, and to Bacillus halodurans N-acyl-L-amino acid amidohydrolase BH1613 TR:Q9KCF8 (EMBL:AP001512) (404 aa) fasta scores: E(): 2.6e-68, 48.518% id in 371 aa; peptidase 604641 2861087 SAR0554 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_040003.1 603466 R 282458 CDS YP_040004.1 49482780 2859679 604812..605999 1 NC_002952.2 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 605999 kbl 2859679 kbl Staphylococcus aureus subsp. aureus MRSA252 2-amino-3-ketobutyrate coenzyme A ligase YP_040004.1 604812 D 282458 CDS YP_040005.1 49482781 2861088 606275..607153 1 NC_002952.2 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 607153 2861088 SAR0556 Staphylococcus aureus subsp. aureus MRSA252 chaperone protein HchA YP_040005.1 606275 D 282458 CDS YP_040006.1 49482782 2861089 607311..608948 1 NC_002952.2 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 608948 2861089 SAR0557 Staphylococcus aureus subsp. aureus MRSA252 ribulokinase YP_040006.1 607311 D 282458 CDS YP_040007.1 49482783 2860131 609162..610127 1 NC_002952.2 Similar to Staphylococcus carnosus hypothetical protein TR:Q9F331 (EMBL:AJ279090) (248 aa) fasta scores: E(): 4.6e-70, 74.486% id in 243 aa, and to Thermoplasma acidophilum UDP-glucose 4-epimerase related protein TA1111 TR:Q9HJ61 (EMBL:AL445066) (317 aa) fasta scores: E(): 1.3e-50, 48.077% id in 312 aa; hypothetical protein 610127 2860131 SAR0558 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040007.1 609162 D 282458 CDS YP_040008.1 49482784 2860132 610462..611538 1 NC_002952.2 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 611538 2860132 SAR0559 Staphylococcus aureus subsp. aureus MRSA252 branched-chain amino acid aminotransferase YP_040008.1 610462 D 282458 CDS YP_040009.1 49482785 2860133 611789..612472 1 NC_002952.2 Similar to Escherichia coli phosphoglycolate phosphatase Gph SW:GPH_ECOLI (P32662) (252 aa) fasta scores: E(): 3.3e-05, 25.957% id in 235 aa, and to Staphylococcus carnosus hypothetical protein TR:Q9F327 (EMBL:AJ279090) (239 aa) fasta scores: E(): 4.2e-37, 50.216% id in 231 aa; haloacid dehalogenase-like hydrolase 612472 2860133 SAR0560 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_040009.1 611789 D 282458 CDS YP_040010.1 49482786 2860134 complement(612588..613250) 1 NC_002952.2 Similar to Lactobacillus acidophilus deoxyadenosine kinase subunit protein SW:DGK1_LACAC (Q59483) (214 aa) fasta scores: E(): 1e-17, 34.314% id in 204 aa, and to Bacillus subtilis hypothetical protein YaaF SW:YAAF_BACSU (P37529) (217 aa) fasta scores: E(): 7.8e-52, 64.151% id in 212 aa; deoxyadenosine kinase 613250 2860134 SAR0561 Staphylococcus aureus subsp. aureus MRSA252 deoxyadenosine kinase YP_040010.1 612588 R 282458 CDS YP_040011.1 49482787 2860135 complement(613243..613860) 1 NC_002952.2 Similar to Lactobacillus acidophilus deoxyadenosine kinase subunit protein SW:DGK1_LACAC (Q59483) (214 aa) fasta scores: E(): 0.00015, 30.986% id in 213 aa, and to Bacillus subtilis hypothetical protein YaaG SW:YAAG_BACSU (P37530) (207 aa) fasta scores: E(): 1.6e-27, 48.990% id in 198 aa; deoxyadenosine kinase 613860 2860135 SAR0562 Staphylococcus aureus subsp. aureus MRSA252 deoxyadenosine kinase YP_040011.1 613243 R 282458 CDS YP_040012.1 49482788 2860136 613927..614397 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YaaJ SW:YAAJ_BACSU (P21335) (161 aa) fasta scores: E(): 1.2e-36, 61.039% id in 154 aa, and to Lactococcus lactis hypothetical protein YhcI TR:Q9CHK8 (EMBL:AE006305) (155 aa) fasta scores: E(): 4.5e-27, 50.694% id in 144 aa; deaminase 614397 2860136 SAR0563 Staphylococcus aureus subsp. aureus MRSA252 deaminase YP_040012.1 613927 D 282458 CDS YP_040013.1 49482789 2860137 614544..615413 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1746 TR:Q9KC28 (EMBL:AP001513) (282 aa) fasta scores: E(): 1.9e-38, 45.423% id in 284 aa, and to Bacillus subtilis hypothetical protein YwtE TR:P96741 (EMBL:Z92954) (286 aa) fasta scores: E(): 1.9e-23, 34.146% id in 287 aa; haloacid dehalogenase-like hydrolase 615413 2860137 SAR0564 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_040013.1 614544 D 282458 CDS YP_040014.1 49482790 2860138 615433..615999 1 NC_002952.2 Similar to Bacillus sp OY1-2 azoreductase Azr TR:Q9FAW5 (EMBL:AB032601) (178 aa) fasta scores: E(): 1.4e-06, 32.778% id in 180 aa, and to Amycolatopsis mediterranei hypothtetical protein UrdO TR:CAC42480 (EMBL:AJ318385) (196 aa) fasta scores: E(): 3.1e-06, 29.379% id in 177 aa; hypothetical protein 615999 2860138 SAR0565 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040014.1 615433 D 282458 CDS YP_040015.1 49482791 2859132 616430..619150 1 NC_002952.2 Similar to Staphylococcus aureus serine-aspartate repeat protein multigene family protein SdrC TR:O86487 (EMBL:AJ005645) (947 aa) fasta scores: E(): 7.4e-214, 87.751% id in 947 aa, and to Staphylococcus aureus bone sialoprotein-binding protein Bbp TR:Q9KWX6 (EMBL:Y18653) (1171 aa) fasta scores: E(): 3e-96, 47.355% id in 1172 aa. CDS contains dipetide repeat (SD x71) between residues 708 and 847. In comparison to the SdrC protein, the CDS contains extra copies of the SD repeat. Probable LPXTG-sorted surface protein; surface anchored protein 619150 sdrC 2859132 sdrC Staphylococcus aureus subsp. aureus MRSA252 surface anchored protein YP_040015.1 616430 D 282458 CDS YP_040016.1 49482792 2859885 619547..622960 1 NC_002952.2 Similar to Staphylococcus aureus bone sialoprotein-binding protein Bbp TR:Q9KWX6 (EMBL:Y18653) (1171 aa) fasta scores: E(): 0, 95.559% id in 1171 aa, and to Staphylococcus aureus serine-aspartate repeat protein multigene family protein SdrE TR:O86489 (EMBL:AJ005647) (1166 aa) fasta scores: E(): 0, 84.991% id in 1166 aa. CDS contains dipetide repeat (SD x74) between residues 935 and 1078. In comparison to the Bpp protein, the CDS contains less copies of the SD repeat. Probable LPXTG-sorted surface protein; bone sialoprotein-binding protein 622960 bbp 2859885 bbp Staphylococcus aureus subsp. aureus MRSA252 bone sialoprotein-binding protein YP_040016.1 619547 D 282458 CDS YP_040017.1 49482793 2860139 623079..624551 1 NC_002952.2 Similar to Lactococcus lactis lipopolysaccharide biosynthesis protein YohJ TR:Q9CFL4 (EMBL:AE006375) (506 aa) fasta scores: E(): 1.4e-30, 26.969% id in 508 aa. Internal region of the CDS is similar to an internal region of Bacillus subtilis probable UDP-glucose:polyglycerol phosphate glucosyltransferase TagE SW:TAGE_BACSU (P13484) (673 aa) fasta scores: E(): 6.9e-23, 25.798% id in 376 aa; glycosyl transferase family protein 624551 2860139 SAR0568 Staphylococcus aureus subsp. aureus MRSA252 glycosyl transferase family protein YP_040017.1 623079 D 282458 CDS YP_040018.1 49482794 2860140 complement(624677..626167) 1 NC_002952.2 Similar to Lactococcus lactis lipopolysaccharide biosynthesis protein YohJ TR:Q9CFL4 (EMBL:AE006375) (506 aa) fasta scores: E(): 2.3e-28, 26.600% id in 500 aa. Internal region of the CDS is similar to an internal region of Bacillus subtilis probable UDP-glucose:polyglycerol phosphate glucosyltransferase TagE SW:TAGE_BACSU (P13484) (673 aa) fasta scores: E(): 2e-22, 23.633% id in 512 aa; glycosyl transferase family protein 626167 2860140 SAR0569 Staphylococcus aureus subsp. aureus MRSA252 glycosyl transferase family protein YP_040018.1 624677 R 282458 CDS YP_040019.1 49482795 2860141 complement(626449..627327) 1 NC_002952.2 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis; GTP cyclohydrolase 627327 2860141 SAR0570 Staphylococcus aureus subsp. aureus MRSA252 GTP cyclohydrolase YP_040019.1 626449 R 282458 CDS YP_040020.1 49482796 2860142 complement(627340..628005) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3320 TR:Q9K7P1 (EMBL:AP001518) (227 aa) fasta scores: E(): 3.5e-44, 54.709% id in 223 aa. C-terminal region is similar to Bacillus subtilis hypothetical protein YojG TR:O31857 (EMBL:Z99114) (142 aa) fasta scores: E(): 5.4e-18, 41.727% id in 139 aa; hypothetical protein 628005 2860142 SAR0571 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040020.1 627340 R 282458 CDS YP_040021.1 49482797 2860143 complement(628019..628378) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3319 TR:Q9K7P2 (EMBL:AP001518) (115 aa) fasta scores: E(): 3.1e-23, 52.542% id in 118 aa, and to Bacillus subtilis hypothetical protein YojF TR:O31858 (EMBL:Z99114) (116 aa) fasta scores: E(): 1.7e-16, 39.496% id in 119 aa; hypothetical protein 628378 2860143 SAR0572 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040021.1 628019 R 282458 CDS YP_040022.1 49482798 2860144 628658..629416 1 NC_002952.2 Similar to Giardia lamblia glucosamine-6-phosphate isomerase 1 GPI1 SW:GNP1_GIALA (O97439) (266 aa) fasta scores: E(): 5e-31, 44.076% id in 211 aa, and to Bacillus subtilis glucosamine-6-phosphate isomerase NagB SW:NAGB_BACSU (O35000) (242 aa) fasta scores: E(): 1.5e-35, 45.188% id in 239 aa; glucosamine-6-phosphate isomerase 629416 2860144 SAR0573 Staphylococcus aureus subsp. aureus MRSA252 glucosamine-6-phosphate isomerase YP_040022.1 628658 D 282458 CDS YP_040023.1 49482799 2860019 629493..630125 1 NC_002952.2 Similar to Methylomonas aminofaciens hexulose-6-phosphate synthase Hps SW:HUMS_METAM (Q48907) (208 aa) fasta scores: E(): 1.4e-21, 40.704% id in 199 aa, and to Bacillus subtilis probable hexulose-6-phosphate synthase YckG SW:HUMS_BACSU (P42405) (210 aa) fasta scores: E(): 6.8e-38, 56.039% id in 207 aa; hexulose-6-phosphate synthase 630125 2860019 SAR0574 Staphylococcus aureus subsp. aureus MRSA252 hexulose-6-phosphate synthase YP_040023.1 629493 D 282458 CDS YP_040024.1 49482800 2859822 630127..630675 1 NC_002952.2 Similar to Methylomonas aminofaciens 6-phospho-3-hexuloisomerase RmpB TR:Q9S0X3 (EMBL:AB026428) (181 aa) fasta scores: E(): 2.4e-16, 36.364% id in 187 aa, and to Bacillus subtilis hypothetical protein YckF SW:YCKF_BACSU (P42404) (185 aa) fasta scores: E(): 5.6e-21, 43.182% id in 176 aa; 6-phospho 3-hexuloisomerase 630675 2859822 SAR0575 Staphylococcus aureus subsp. aureus MRSA252 6-phospho 3-hexuloisomerase YP_040024.1 630127 D 282458 CDS YP_040025.1 49482801 2860020 630788..631435 1 NC_002952.2 Similar to Erwinia chrysanthemi probable indigoidine systhesis protein IdgB TR:Q9KHB5 (EMBL:AF265211) (230 aa) fasta scores: E(): 9.7e-14, 28.910% id in 211 aa, and to Bacillus halodurans phosphoglycolate phosphatase BH3587 TR:Q9K6Y7 (EMBL:AP001519) (215 aa) fasta scores: E(): 1.5e-11, 23.256% id in 215 aa; haloacid dehalogenase-like hydrolase 631435 2860020 SAR0576 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_040025.1 630788 D 282458 CDS YP_040026.1 49482802 2860152 631938..633338 1 NC_002952.2 Similar to Escherichia coli proline/betaine transporter ProP SW:PROP_ECOLI (P30848) (500 aa) fasta scores: E(): 2e-63, 38.158% id in 456 aa, and to Streptomyces coelicolor integral membrane transport protein SCC53.27 TR:Q9KXI4 (EMBL:AL357591) (462 aa) fasta scores: E(): 2.2e-72, 45.767% id in 437 aa; proline/betaine transporter 633338 proP 2860152 proP Staphylococcus aureus subsp. aureus MRSA252 proline/betaine transporter YP_040026.1 631938 D 282458 CDS YP_040027.1 49482803 2860021 633590..633883 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 633883 2860021 SAR0578 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040027.1 633590 D 282458 CDS YP_040028.1 49482804 2860996 633883..635259 1 NC_002952.2 Similar to Staphylococcus aureus menaquinone biosynthesis protein, O-succinylbenzoic acid--CoA ligase MenE SW:MENE_STAAU (Q53634) (492 aa) fasta scores: E(): 3.2e-16, 23.974% id in 463 aa. Previously sequenced as Staphylococcus aureus long chain fatty acid CoA ligase VraA TR:Q9KWK5 (EMBL:AB035449) (458 aa) fasta scores: E(): 1.1e-174, 97.817% id in 458 aa; AMP-binding protein 635259 2860996 SAR0580 Staphylococcus aureus subsp. aureus MRSA252 AMP-binding protein YP_040028.1 633883 D 282458 CDS YP_040029.1 49482805 2860997 635261..636400 1 NC_002952.2 Similar to Escherichia coli 3-ketoacyl-CoA thiolase FadA SW:THIK_ECOLI (P21151) (387 aa) fasta scores: E(): 1.4e-34, 34.091% id in 396 aa. Previously sequenced as Staphylococcus aureus acetyl-CoA c-acetyltransferase VraB TR:Q9KWK4 (EMBL:AB035449) (379 aa) fasta scores: E(): 8.9e-143, 98.681% id in 379 aa; ketoacyl-CoA thiolase 636400 2860997 SAR0581 Staphylococcus aureus subsp. aureus MRSA252 ketoacyl-CoA thiolase YP_040029.1 635261 D 282458 CDS YP_040030.1 49482806 2860998 636375..636740 1 NC_002952.2 Poor database matches. Similar to an internal region of Guillardia theta hypothetical protein chromosome 1 Orf183 TR:AAK39951 (EMBL:AF165818) (183 aa) fasta scores: E(): 2.5, 29.167% id in 120 aa; hypothetical protein 636740 2860998 SAR0582 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040030.1 636375 D 282458 CDS YP_040031.1 49482807 2860999 636743..637012 1 NC_002952.2 Poor database matches. Similar to Lactococcus lactis hypothetical protein YseD TR:Q9CEQ1 (EMBL:AE006408) (97 aa) fasta scores: E(): 1.1, 27.586% id in 87 aa; hypothetical protein 637012 2860999 SAR0583 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040031.1 636743 D 282458 CDS YP_040032.1 49482808 2860022 complement(637213..637380) 1 NC_002952.2 hypothetical protein 637380 2860022 SAR0584 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040032.1 637213 R 282458 CDS YP_040033.1 49482809 2860023 complement(637913..638743) 1 NC_002952.2 Similar to Staphylococcus carnosus thiamin biosynthesis protein ThiD TR:Q9RGS7 (EMBL:AF109218) (273 aa) fasta scores: E(): 2.8e-28, 38.095% id in 273 aa, and to Bacillus subtilis phosphomethylpyrimidine kinase ThiD SW:THID_BACSU (P39610) (271 aa) fasta scores: E(): 1.8e-47, 51.136% id in 264 aa; phosphomethylpyrimidine kinase 638743 2860023 SAR0585 Staphylococcus aureus subsp. aureus MRSA252 phosphomethylpyrimidine kinase YP_040033.1 637913 R 282458 CDS YP_040034.1 49482810 2860413 638927..639583 1 NC_002952.2 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 639583 ung 2860413 ung Staphylococcus aureus subsp. aureus MRSA252 uracil-DNA glycosylase YP_040034.1 638927 D 282458 CDS YP_040035.1 49482811 2861007 639584..639964 1 NC_002952.2 hypothetical protein 639964 2861007 SAR0587 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040035.1 639584 D 282458 CDS YP_040036.1 49482812 2861008 640097..640465 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YywK SW:YWDK_BACSU (P39619) (113 aa) fasta scores: E(): 3.4e-20, 60.577% id in 104 aa, and to Bacillus halodurans hypothetical protein BH3828 TR:Q9K6A1 (EMBL:AP001520) (121 aa) fasta scores: E(): 7.1e-17, 45.455% id in 121 aa; hypothetical protein 640465 2861008 SAR0588 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040036.1 640097 D 282458 CDS YP_040037.1 49482813 2861009 640586..642070 1 NC_002952.2 C-terminal region is similar to Bacillus halodurans hypothetical protein BH0994 TR:Q9KE64 (EMBL:AP001510) (395 aa) fasta scores: E(): 8.9e-35, 31.156% id in 398 aa. Full length CDS is weakly similar to Streptomyces coelicolor amino acid transporter protein SCM10.26 TR:Q9RCX2 (EMBL:AL133469) (468 aa) fasta scores: E(): 5.6e-16, 26.509% id in 464 aa; amino acid permease 642070 2861009 SAR0589 Staphylococcus aureus subsp. aureus MRSA252 amino acid permease YP_040037.1 640586 D 282458 CDS YP_040038.1 49482814 2860024 complement(642212..642664) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0082 TR:Q9KGH9 (EMBL:AP001507) (150 aa) fasta scores: E(): 3.2e-10, 34.109% id in 129 aa, and to Pasteurella multocida hypothetical protein PM1894 TR:Q9CJU7 (EMBL:AE006227) (153 aa) fasta scores: E(): 0.00055, 25.000% id in 132 aa; hypothetical protein 642664 2860024 SAR0590 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040038.1 642212 R 282458 CDS YP_040039.1 49482815 2860025 complement(642677..643441) 1 NC_002952.2 Similar to Streptococcus pneumoniae conserved hypothetical protein SP1731 TR:AAK75807 (EMBL:AE007466) (252 aa) fasta scores: E(): 1.9e-20, 35.547% id in 256 aa, and to Bacillus halodurans hypothetical protein BH0081 TR:Q9KGI0 (EMBL:AP001507) (251 aa) fasta scores: E(): 5.1e-20, 34.156% id in 243 aa; hypothetical protein 643441 2860025 SAR0591 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040039.1 642677 R 282458 CDS YP_040040.1 49482816 2860026 643752..643949 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 643949 2860026 SAR0592 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040040.1 643752 D 282458 CDS YP_040041.1 49482817 2860027 complement(643989..644741) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwfI SW:YWFI_BACSU (P39645) (254 aa) fasta scores: E(): 2e-67, 63.710% id in 248 aa, and to Bacillus halodurans hypothetical protein BH3825 TR:Q9K6A4 (EMBL:AP001520) (261 aa) fasta scores: E(): 2.6e-65, 59.036% id in 249 aa; heme peroxidase 644741 2860027 SAR0593 Staphylococcus aureus subsp. aureus MRSA252 heme peroxidase YP_040041.1 643989 R 282458 CDS YP_040042.1 49482818 2860155 644909..645895 1 NC_002952.2 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 645895 eutD 2860155 eutD Staphylococcus aureus subsp. aureus MRSA252 phosphotransacetylase YP_040042.1 644909 D 282458 CDS YP_040043.1 49482819 2860028 645898..646734 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3822 TR:Q9K6A7 (EMBL:AP001520) (278 aa) fasta scores: E(): 1.6e-53, 51.321% id in 265 aa, and to Bacillus subtilis hypothetical protein YwfL SW:YWFL_BACSU (P39648) (281 aa) fasta scores: E(): 2.4e-51, 53.358% id in 268 aa; lipoate-protein ligase A protein 646734 2860028 SAR0595 Staphylococcus aureus subsp. aureus MRSA252 lipoate-protein ligase A protein YP_040043.1 645898 D 282458 CDS YP_040044.1 49482820 2861330 647321..648241 1 NC_002952.2 Previously sequenced as Staphylococcus aureus mevalonate kinase MvaK1 TR:Q9FD85 (EMBL:AF290087) (306 aa) fasta scores: E(): 7e-112, 99.346% id in 306 aa. Similar to Staphylococcus epidermidis mevalonate kinase MvaK1 TR:Q9FD74 (EMBL:AF290091) (306 aa) fasta scores: E(): 1e-88, 77.451% id in 306 aa; mevalonate kinase 648241 mvaK1 2861330 mvaK1 Staphylococcus aureus subsp. aureus MRSA252 mevalonate kinase YP_040044.1 647321 D 282458 CDS YP_040045.1 49482821 2861329 648246..649229 1 NC_002952.2 Previously sequenced as Staphylococcus aureus mevalonate diphosphate decarboxylase MvaD TR:Q9FD84 (EMBL:AF290087) (327 aa) fasta scores: E(): 4.3e-124, 99.388% id in 327 aa. Similar to Staphylococcus haemolyticus mevalonate diphosphate decarboxylase MvaD TR:Q9FD78 (EMBL:AF290089) (327 aa) fasta scores: E(): 5.1e-91, 73.538% id in 325 aa; mevalonate diphosphate decarboxylase 649229 mvaD 2861329 mvaD Staphylococcus aureus subsp. aureus MRSA252 mevalonate diphosphate decarboxylase YP_040045.1 648246 D 282458 CDS YP_040046.1 49482822 2861331 649242..650318 1 NC_002952.2 Previously sequenced as Staphylococcus aureus phosphomevalonate kinase MvaK2 TR:Q9FD83 (EMBL:AF290087) (358 aa) fasta scores: E(): 4.2e-144, 99.721% id in 358 aa. Similar to Staphylococcus haemolyticus phosphomevalonate kinase MvaK2 TR:Q9FD77 (EMBL:AF290089) (358 aa) fasta scores: E(): 7.4e-118, 79.609% id in 358 aa; phosphomevalonate kinase 650318 mvaK2 2861331 mvaK2 Staphylococcus aureus subsp. aureus MRSA252 phosphomevalonate kinase YP_040046.1 649242 D 282458 CDS YP_040047.1 49482823 2860029 650495..650836 1 NC_002952.2 No significant database matches to the full length CDS. N-terminal region is similar to Bacillus subtilis hypothetical protein YwzC TR:O32280 (EMBL:Z99123) (74 aa) fasta scores: E(): 1.6e-13, 63.514% id in 74 aa, and to Bacillus halodurans hypothetical protein BH3821 TR:Q9K6A8 (EMBL:AP001520) (74 aa) fasta scores: E(): 6.5e-13, 67.568% id in 74 aa. CDS contains N-terminal hydrophilic region; hypothetical protein 650836 2860029 SAR0599 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040047.1 650495 D 282458 CDS YP_040048.1 49482824 2860030 complement(650888..652210) 1 NC_002952.2 Similar to Burkholderia cepacia glutathione reductase Gor SW:GSHR_BURCE (P48639) (449 aa) fasta scores: E(): 6.1e-35, 30.853% id in 457 aa, and to Escherichia coli probable pyridine nucleotide-disulfide oxidoreductase YkgC SW:YKGC_ECOLI (P77212) (450 aa) fasta scores: E(): 1.1e-79, 49.433% id in 441 aa; pyridine nucleotide-disulfide oxidoreductase 652210 2860030 SAR0600 Staphylococcus aureus subsp. aureus MRSA252 pyridine nucleotide-disulfide oxidoreductase YP_040048.1 650888 R 282458 CDS YP_040049.1 49482825 2860236 complement(652197..652637) 1 NC_002952.2 Poor database matches. Weak similarity to Bacillus halodurans hypothetical protein BH0656 TR:Q9Z9W2 (EMBL:AB011836) (132 aa) fasta scores: E(): 0.042, 25.373% id in 134 aa, and Pseudomonas aeruginosa probable transcriptional regulator PA2692 TR:Q9I0F0 (EMBL:AE004697) (174 aa) fasta scores: E(): 9.8, 25.714% id in 140 aa; hypothetical protein 652637 2860236 SAR0601 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040049.1 652197 R 282458 CDS YP_040050.1 49482826 2860237 653261..654655 1 NC_002952.2 N-terminal region is similar to Staphylococcus haemolyticus hypothetical protein TR:Q9F2H7 (EMBL:AJ302698) (373 aa) fasta scores: E(): 4.1e-43, 46.076% id in 395 aa. Full length CDS is similar to Bacillus halodurans transposase BH0978 TR:Q9KE78 (EMBL:AP001510) (503 aa) fasta scores: E(): 9e-14, 24.540% id in 489 aa; hypothetical protein 654655 2860237 SAR0602 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040050.1 653261 D 282458 CDS YP_040051.1 49482827 2860238 654659..655294 1 NC_002952.2 Poor database matches. Similar to Staphylococcus haemolyticus hypothetical protein TR:Q9F2H5 (EMBL:AJ302698) (220 aa) fasta scores: E(): 3.5e-06, 24.645% id in 211 aa. Similar to SAR0607, 52.451% identity (52.709% ungapped) in 204 aa overlap; hypothetical protein 655294 2860238 SAR0603 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040051.1 654659 D 282458 CDS YP_040052.1 49482828 2860239 655260..655529 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start site. Similar to the C-terminal region of SAR0602, 65.789% identity (69.444% ungapped) in 76 aa overlap; hypothetical protein 655529 2860239 SAR0604 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040052.1 655260 D 282458 CDS YP_040053.1 49482829 2860241 656291..656920 1 NC_002952.2 Similar to Staphylococcus haemolyticus hypothetical protein TR:Q9F2H5 (EMBL:AJ302698) (220 aa) fasta scores: E(): 8.6e-06, 25.000% id in 192 aa. Similar to SAR0603, 52.451% identity (52.709% ungapped) in 204 aa overlap, and to the N-terminal region of SAR0605, 66.667% identity (66.667% ungapped) in 66 aa overlap; hypothetical protein 656920 2860241 SAR0607 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040053.1 656291 D 282458 CDS YP_040054.1 49482830 2860242 657373..658311 1 NC_002952.2 Similar to Bacillus subtilis possible inositol catabolism protein IolS SW:IOLS_BACSU (P46336) (310 aa) fasta scores: E(): 3.1e-65, 60.450% id in 311 aa, and to Thermotoga maritima aldo/keto reductase oxidoreductase TM1006 TR:Q9X0A1 (EMBL:AE001762) (333 aa) fasta scores: E(): 1.3e-25, 35.783% id in 313 aa; aldo/keto reductase 658311 2860242 SAR0608 Staphylococcus aureus subsp. aureus MRSA252 aldo/keto reductase YP_040054.1 657373 D 282458 CDS YP_040055.1 49482831 2860243 658521..659057 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwqN TR:P96726 (EMBL:Z92952) (181 aa) fasta scores: E(): 5.9e-27, 42.353% id in 170 aa, and to Streptomyces coelicolor hypothetical protein SCD20.05c TR:Q9F2X4 (EMBL:AL392148) (200 aa) fasta scores: E(): 2.8e-16, 33.140% id in 172 aa; hypothetical protein 659057 2860243 SAR0609 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040055.1 658521 D 282458 CDS YP_040056.1 49482832 2860244 659226..659702 1 NC_002952.2 Similar to Sus scrofa (Pig) diamine acetyltransferase Sat SW:ATDA_PIG (Q28999) (171 aa) fasta scores: E(): 0.01, 28.477% id in 151 aa, and to Rhizobium loti hypothetical protein MLR0192 TR:BAB47829 (EMBL:AP002994) (163 aa) fasta scores: E(): 1.3e-09, 37.419% id in 155 aa; acetyltransferase 659702 2860244 SAR0610 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_040056.1 659226 D 282458 CDS YP_040057.1 49482833 2860245 659742..661037 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwfO SW:YWFO_BACSU (P39651) (433 aa) fasta scores: E(): 4.1e-108, 64.320% id in 412 aa, and to Bacillus halodurans hypothetical protein BH3818 TR:Q9K6B1 (EMBL:AP001520) (432 aa) fasta scores: E(): 1.8e-101, 59.028% id in 432 aa; phosphohydrolase 661037 2860245 SAR0611 Staphylococcus aureus subsp. aureus MRSA252 phosphohydrolase YP_040057.1 659742 D 282458 CDS YP_040058.1 49482834 2860246 661080..661586 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwhD TR:P70996 (EMBL:Z80360) (172 aa) fasta scores: E(): 9e-40, 57.576% id in 165 aa, and to Bacillus halodurans hypothetical protein BH3813 TR:Q9K6B6 (EMBL:AP001520) (179 aa) fasta scores: E(): 7.2e-30, 46.626% id in 163 aa; hypothetical protein 661586 2860246 SAR0612 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040058.1 661080 D 282458 CDS YP_040059.1 49482835 2859061 662085..663095 1 NC_002952.2 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 663095 adhA 2859061 adhA Staphylococcus aureus subsp. aureus MRSA252 alcohol dehydrogenase YP_040059.1 662085 D 282458 CDS YP_040060.1 49482836 2860247 663359..663787 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwiB TR:O07624 (EMBL:Z97024) (142 aa) fasta scores: E(): 3.9e-07, 26.471% id in 136 aa, and to Bacillus halodurans hypothetical protein BH3809 TR:Q9K6C0 (EMBL:AP001520) (144 aa) fasta scores: E(): 0.0088, 24.088% id in 137 aa; hypothetical protein 663787 2860247 SAR0614 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040060.1 663359 D 282458 CDS YP_040061.1 49482837 2859857 663784..665445 1 NC_002952.2 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 665445 argS 2859857 argS Staphylococcus aureus subsp. aureus MRSA252 arginyl-tRNA synthetase YP_040061.1 663784 D 282458 CDS YP_040062.1 49482838 2860248 665852..666487 1 NC_002952.2 Similar to Methanococcus jannaschii hypothetical protein MJ1434 TR:Q58829 (EMBL:U67584) (220 aa) fasta scores: E(): 4.4e-23, 37.198% id in 207 aa, and to Thermotoga maritima repair endonuclease TM0382 TR:Q9WYL3 (EMBL:AE001718) (232 aa) fasta scores: E(): 4.8e-17, 35.417% id in 192 aa; DNA repair protein 666487 2860248 SAR0617 Staphylococcus aureus subsp. aureus MRSA252 DNA repair protein YP_040062.1 665852 D 282458 CDS YP_040063.1 49482839 2860249 666806..667693 1 NC_002952.2 Similar to Salmonella typhimurium cobalamin transport periplasmic binding protein BtuF TR:Q9ZFP9 (EMBL:AF096877) (266 aa) fasta scores: E(): 2.8e-09, 26.482% id in 253 aa, and to Bacillus subtilis metal binding protein YvrC TR:O34805 (EMBL:Z99120) (314 aa) fasta scores: E(): 2.2e-33, 41.667% id in 312 aa; transport system lipoprotein 667693 2860249 SAR0618 Staphylococcus aureus subsp. aureus MRSA252 transport system lipoprotein YP_040063.1 666806 D 282458 CDS YP_040064.1 49482840 2860250 667843..668793 1 NC_002952.2 Similar to Bacillus subtilis hemin permease YvrB TR:O34451 (EMBL:Z99120) (353 aa) fasta scores: E(): 2.1e-23, 32.143% id in 308 aa, and to Pyrococcus abyssi iron (III) ABC transporter, permease PAB1535 TR:Q9UZ79 (EMBL:AJ248287) (331 aa) fasta scores: E(): 2.7e-21, 30.744% id in 309 aa; FecCD transport family protein 668793 2860250 SAR0619 Staphylococcus aureus subsp. aureus MRSA252 FecCD transport family protein YP_040064.1 667843 D 282458 CDS YP_040065.1 49482841 2860251 668848..669567 1 NC_002952.2 Similar to Burkholderia cepacia 2-haloalkanoic acid dehalogenase IVa Hdl IVa SW:HAD4_BURCE (Q51645) (230 aa) fasta scores: E(): 5e-06, 24.771% id in 218 aa, and to Pyrococcus horikoshii hypothetical protein PH0459 TR:O58216 (EMBL:AP000002) (232 aa) fasta scores: E(): 3e-11, 27.706% id in 231 aa; haloacid dehalogenase-like hydrolase 669567 2860251 SAR0620 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_040065.1 668848 D 282458 CDS YP_040066.1 49482842 2860252 669551..670351 1 NC_002952.2 Similar to Pseudomonas sp esterase V Est5 TR:Q9Z3U8 (EMBL:D14529) (262 aa) fasta scores: E(): 3e-08, 23.755% id in 261 aa, and to Archaeoglobus fulgidus putataive 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase AF1706 TR:O28567 (EMBL:AE000986) (238 aa) fasta scores: E(): 3.8e-13, 28.139% id in 231 aa; hydrolase 670351 2860252 SAR0621 Staphylococcus aureus subsp. aureus MRSA252 hydrolase YP_040066.1 669551 D 282458 CDS YP_040067.1 49482843 2860253 670487..670993 1 NC_002952.2 No significant database matches to the full length CDS. N-terminus is weakly similar to the N-terminal region of Clostridium acetobutylicum regulatory protein TR:Q45805 (EMBL:U15277) (148 aa) fasta scores: E(): 9.7, 22.018% id in 109 aa; hypothetical protein 670993 2860253 SAR0622 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040067.1 670487 D 282458 CDS YP_040068.1 49482844 2860254 671155..671871 1 NC_002952.2 No significant database matches to the full length CDS. C-terminus is weakly similar to the N-terminal region of Phytophthora infestans mitochondrial SecY-independent transporter protein Ymf16 TR:Q9T238 (EMBL:U17009) (248 aa) fasta scores: E(): 0.78, 25.806% id in 186 aa; hypothetical protein 671871 2860254 SAR0623 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040068.1 671155 D 282458 CDS YP_040069.1 49482845 2860255 672040..672828 1 NC_002952.2 Similar to Pseudomonas sp esterase V Est5 TR:Q9Z3U8 (EMBL:D14529) (262 aa) fasta scores: E(): 1.1e-08, 24.904% id in 261 aa, and to Vibrio cholerae esterase/lipase YbfF TR:Q9KQA3 (EMBL:AE004283) (257 aa) fasta scores: E(): 8.7e-12, 24.615% id in 260 aa; esterase 672828 2860255 SAR0624 Staphylococcus aureus subsp. aureus MRSA252 esterase YP_040069.1 672040 D 282458 CDS YP_040070.1 49482846 2861466 complement(673078..673452) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus agr regulon and exoprotein expression regulator, staphylococcal accessory regulator A, SarA TR:Q53777 (EMBL:U46541) (113 aa) fasta scores: E(): 4.5e-36, 99.115% id in 113 aa. Similar to Staphylococcus epidermidis staphylococcal accessory regulator A homologue SarA TR:O85233 (EMBL:AF054173) (124 aa) fasta scores: E(): 9e-35, 85.484% id in 124 aa; accessory regulator A 673452 sarA 2861466 sarA Staphylococcus aureus subsp. aureus MRSA252 accessory regulator A YP_040070.1 673078 R 282458 CDS YP_040071.1 49482847 2860256 complement(674399..675328) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YsbC TR:Q9CES9 (EMBL:AE006405) (307 aa) fasta scores: E(): 2.6e-26, 33.974% id in 312 aa. N-terminal region is similar to Pasteurella multocida hypothetical protein PM1890 TR:Q9CJV1 (EMBL:AE006226) (156 aa) fasta scores: E(): 9.6e-09, 33.333% id in 147 aa; hypothetical protein 675328 2860256 SAR0626 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040071.1 674399 R 282458 CDS YP_040072.1 49482848 2860257 complement(675521..675745) 1 NC_002952.2 hypothetical protein 675745 2860257 SAR0627 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040072.1 675521 R 282458 CDS YP_040073.1 49482849 2860258 complement(675762..675965) 1 NC_002952.2 hypothetical protein 675965 2860258 SAR0628 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040073.1 675762 R 282458 CDS YP_040074.1 49482850 2860259 676120..676680 1 NC_002952.2 Similar to Escherichia coli type 1 fimbriae regulatory protein FimE SW:FIME_ECOLI (P04741) (198 aa) fasta scores: E(): 2.3e-06, 30.488% id in 164 aa, and to Bacillus halodurans hypothetical protein BH4039 TR:Q9K5P9 (EMBL:AP001520) (182 aa) fasta scores: E(): 3.7e-14, 32.934% id in 167 aa; phage integrase 676680 2860259 SAR0629 Staphylococcus aureus subsp. aureus MRSA252 phage integrase YP_040074.1 676120 D 282458 CDS YP_040075.1 49482851 2860260 676699..679101 1 NC_002952.2 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit A 679101 2860260 SAR0630 Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit A YP_040075.1 676699 D 282458 CDS YP_040076.1 49482852 2860261 679088..679513 1 NC_002952.2 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit B 679513 2860261 SAR0631 Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit B YP_040076.1 679088 D 282458 CDS YP_040077.1 49482853 2860262 679510..679854 1 NC_002952.2 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit C 679854 2860262 SAR0632 Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit C YP_040077.1 679510 D 282458 CDS YP_040078.1 49482854 2860263 679844..681340 1 NC_002952.2 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; in S. meliloti it is known to be involved specifically with K+ transport; monovalent cation/H+ antiporter subunit D 681340 2860263 SAR0633 Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit D YP_040078.1 679844 D 282458 CDS YP_040079.1 49482855 2860264 681341..681823 1 NC_002952.2 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport; monovalent cation/H+ antiporter subunit E 681823 2860264 SAR0634 Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit E YP_040079.1 681341 D 282458 CDS YP_040080.1 49482856 2860265 681820..682122 1 NC_002952.2 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit F 682122 2860265 SAR0635 Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit F YP_040080.1 681820 D 282458 CDS YP_040081.1 49482857 2860267 682874..684916 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YvgP TR:O32212 (EMBL:Z99121) (670 aa) fasta scores: E(): 1.5e-47, 32.562% id in 691 aa, and to Bifidobacterium longum Na+/H+ antiporter protein NhaB TR:Q9F9W8 (EMBL:AF160969) (690 aa) fasta scores: E(): 2.2e-35, 30.183% id in 709 aa; sodium/hydrogen exchanger family protein 684916 2860267 SAR0637 Staphylococcus aureus subsp. aureus MRSA252 sodium/hydrogen exchanger family protein YP_040081.1 682874 D 282458 CDS YP_040082.1 49482858 2860268 complement(685002..686150) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YbcL TR:O34663 (EMBL:Z99104) (390 aa) fasta scores: E(): 2.3e-23, 25.594% id in 379 aa, and to Pseudomonas aeruginosa probable MFS transporter PA3303 TR:Q9HYU1 (EMBL:AE004752) (391 aa) fasta scores: E(): 9.2e-21, 25.956% id in 366 aa; hypothetical protein 686150 2860268 SAR0638 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040082.1 685002 R 282458 CDS YP_040083.1 49482859 2860270 complement(687790..688719) 1 NC_002952.2 Similar to Staphylococcus epidermidis iron repressible ABC transport system lipoprotein TR:P72415 (EMBL:X99127) (309 aa) fasta scores: E(): 3e-85, 77.023% id in 309 aa, and to Streptococcus pneumoniae surface adhesin A precursor PsaA TR:P72538 (EMBL:U53509) (309 aa) fasta scores: E(): 4.4e-52, 50.489% id in 307 aa; ABC transporter 688719 2860270 SAR0641 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter YP_040083.1 687790 R 282458 CDS YP_040084.1 49482860 2861619 complement(688716..689552) 1 NC_002952.2 Similar to Yersinia pestis chelated iron transport system membrane protein YfeD SW:YFED_YERPE (Q56955) (297 aa) fasta scores: E(): 7.8e-33, 36.496% id in 274 aa, and to Staphylococcus epidermidis iron repressible ABC transport system membrane protein TR:P72414 (EMBL:X99127) (248 aa) fasta scores: E(): 1.4e-64, 83.468% id in 248 aa; ABC transporter permease 689552 2861619 SAR0642 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_040084.1 688716 R 282458 CDS YP_040085.1 49482861 2861620 complement(689546..690289) 1 NC_002952.2 Similar to Treponema pallidum zinc transport system ATP-binding protein TroB SW:TROB_TREPA (P96117) (266 aa) fasta scores: E(): 1e-25, 41.346% id in 208 aa, and to Staphylococcus epidermidis iron repressible ABC transport system ATP binding protein TR:P72413 (EMBL:X99127) (248 aa) fasta scores: E(): 1.2e-51, 67.089% id in 237 aa; ABC transporter ATP-binding protein 690289 2861620 SAR0643 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040085.1 689546 R 282458 CDS YP_040086.1 49482862 2859148 690411..691055 1 NC_002952.2 Similar to Streptococcus gordonii metalloregulator RmtA TR:Q9RFN3 (EMBL:AF182402) (215 aa) fasta scores: E(): 2.6e-24, 37.209% id in 215 aa, and to Staphylococcus epidermidis iron dependant repressor SirR TR:P72424 (EMBL:X99128) (214 aa) fasta scores: E(): 8.5e-66, 82.243% id in 214 aa; metalloregulator 691055 sirR 2859148 sirR Staphylococcus aureus subsp. aureus MRSA252 metalloregulator YP_040086.1 690411 D 282458 CDS YP_040087.1 49482863 2861621 complement(691135..691887) 1 NC_002952.2 Poor database matches. Similar to an internal region of Saccharomyces cerevisiae chromosome XII hypothetical protein YLL031c TR:Q07830 (EMBL:Z73136) (1017 aa) fasta scores: E(): 0.98, 21.992% id in 241 aa; hypothetical protein 691887 2861621 SAR0645 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040087.1 691135 R 282458 CDS YP_040088.1 49482864 2859514 692123..692887 1 NC_002952.2 Similar to Bacillus subtilis teichoic acid biosynthesis protein A TagA SW:TAGA_BACSU (P27620) (256 aa) fasta scores: E(): 1.6e-23, 32.083% id in 240 aa, and to Thermoanaerobacter thermohydrosulfuricus (Clostridium thermohydrosulfuricum) hypothetical protein Lta1 TR:Q9JRP3 (EMBL:AJ401026) (245 aa) fasta scores: E(): 6.6e-31, 37.603% id in 242 aa; teichoic acid biosynthesis protein 692887 tagA 2859514 tagA Staphylococcus aureus subsp. aureus MRSA252 teichoic acid biosynthesis protein YP_040088.1 692123 D 282458 CDS YP_040089.1 49482865 2859518 complement(692947..693741) 1 NC_002952.2 with TagG is involved in the export of teichoic acids; teichoic acids export protein ATP-binding subunit 693741 tagH 2859518 tagH Staphylococcus aureus subsp. aureus MRSA252 teichoic acids export protein ATP-binding subunit YP_040089.1 692947 R 282458 CDS YP_040090.1 49482866 2859517 694067..694900 1 NC_002952.2 Similar to Bacillus subtilis teichoic acid translocation permease TagG SW:TAGG_BACSU (P42953) (275 aa) fasta scores: E(): 7.2e-39, 37.276% id in 279 aa, and to Enterococcus faecalis ABC transporter permease TR:O88086 (EMBL:AF071085) (264 aa) fasta scores: E(): 8.5e-25, 29.963% id in 267 aa. Possible alternative translational start site at codon 8; teichoic acid ABC transporter permease 694900 tagG 2859517 tagG Staphylococcus aureus subsp. aureus MRSA252 teichoic acid ABC transporter permease YP_040090.1 694067 D 282458 CDS YP_040091.1 49482867 2859515 694999..696102 1 NC_002952.2 Similar to Bacillus subtilis teichoic acid biosynthesis protein B TagB SW:TAGB_BACSU (P27621) (381 aa) fasta scores: E(): 4.3e-26, 31.302% id in 361 aa, and to Lactococcus lactis teichoic acid biosynthesis protein B TagB TR:Q9CH14 (EMBL:AE006327) (371 aa) fasta scores: E(): 2.8e-06, 24.834% id in 302 aa. Lack of similarity at the N-terminus in comparison to other orthologues; teichoic acid biosynthesis protein 696102 tagB 2859515 tagB Staphylococcus aureus subsp. aureus MRSA252 teichoic acid biosynthesis protein YP_040091.1 694999 D 282458 CDS YP_040092.1 49482868 2861622 696099..697160 1 NC_002952.2 No significant database matches to the full length CDS. N-terminus is similar to the N-terminal regions of Rhizobium meliloti succinoglycan biosynthesis protein ExoW SW:EXOW_RHIME (P33702) (319 aa) fasta scores: E(): 0.22, 25.000% id in 188 aa, and Streptococcus agalactiae N-acetylglucosaminyltransferase CpsH TR:O87182 (EMBL:AB017355) (333 aa) fasta scores: E(): 0.032, 23.207% id in 237 aa; glycosyl transferase family protein 697160 2861622 SAR0650 Staphylococcus aureus subsp. aureus MRSA252 glycosyl transferase family protein YP_040092.1 696099 D 282458 CDS YP_040093.1 49482869 2859516 697223..697621 1 NC_002952.2 Similar to Bacillus subtilis glycerol-3-phosphate cytidylyltransferase tagD SW:TAGD_BACSU (P27623) (129 aa) fasta scores: E(): 7.1e-36, 69.531% id in 128 aa. Previously sequenced as Staphylococcus aureus glycerol-3-phosphate cytidyltransferase TaqD TR:Q57197 (EMBL:X87105) (132 aa) fasta scores: E(): 6.1e-52, 99.242% id in 132 aa; glycerol-3-phosphate cytidylyltransferase 697621 tagD 2859516 tagD Staphylococcus aureus subsp. aureus MRSA252 glycerol-3-phosphate cytidylyltransferase YP_040093.1 697223 D 282458 CDS YP_040094.1 49482870 2861477 complement(697738..699033) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus penicillin-binding protein 4 Pbp4 TR:P72355 (EMBL:X91786) (431 aa) fasta scores: E(): 7.3e-162, 99.072% id in 431 aa, Similar to Bacillus subtilis D-alanyl-D-alanine carboxypeptidase DacA SW:DACA_BACSU (P08750) (443 aa) fasta scores: E(): 2e-23, 30.789% id in 380 aa; penicillin-binding protein 4 699033 pbp4 2861477 pbp4 Staphylococcus aureus subsp. aureus MRSA252 penicillin-binding protein 4 YP_040094.1 697738 R 282458 CDS YP_040095.1 49482871 2861623 699454..701181 1 NC_002952.2 Similar to Staphylococcus epidermidis lantibiotic Pep5 biosynthetic gene cluster protein PepT TR:Q54121 (EMBL:Z49865) (571 aa) fasta scores: E(): 1.2e-109, 56.348% id in 575 aa. Previously sequenced as Staphylococcus aureus ATP-binding cassette transporter A AbcA TR:P72354 (EMBL:X91786) (575 aa) fasta scores: E(): 1.5e-188, 99.826% id in 575 aa; ABC transporter ATP-binding protein 701181 2861623 SAR0653 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040095.1 699454 D 282458 CDS YP_040097.1 49482873 2861625 701540..702769 1 NC_002952.2 Similar to Escherichia coli nucleoside permease NupC SW:NUPC_ECOLI (P33031) (400 aa) fasta scores: E(): 2.8e-39, 36.000% id in 400 aa, and to Bacillus subtilis hypothetical protein YxjA SW:YXJA_BACSU (P42312) (397 aa) fasta scores: E(): 7.7e-42, 46.229% id in 411 aa; Na+ dependent nucleoside transporter 702769 2861625 SAR0655 Staphylococcus aureus subsp. aureus MRSA252 Na+ dependent nucleoside transporter YP_040097.1 701540 D 282458 CDS YP_040098.1 49482874 2861626 703294..704127 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YxkD TR:P94357 (EMBL:D83026) (278 aa) fasta scores: E(): 3.5e-49, 51.460% id in 274 aa, and to Bacillus halodurans hypothetical protein BH1678 TR:Q9KC95 (EMBL:AP001512) (290 aa) fasta scores: E(): 3.5e-32, 35.507% id in 276 aa; hypothetical protein 704127 2861626 SAR0656 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040098.1 703294 D 282458 CDS YP_040099.1 49482875 2860664 704409..705206 1 NC_002952.2 Previously sequenced as Staphylococcus aureus ferrichrome transport ATP-binding protein FhuA TR:Q9X665 (EMBL:AF132117) (265 aa) fasta scores: E(): 1.2e-89, 100.000% id in 265 aa. Similar to Bacillus subtilis ferrichrome transport ATP-binding protein FhuC SW:FHUC_BACSU (P49938) (269 aa) fasta scores: E(): 3.4e-52, 58.238% id in 261 aa; ferrichrome transport ATP-binding protein 705206 fhuA 2860664 fhuA Staphylococcus aureus subsp. aureus MRSA252 ferrichrome transport ATP-binding protein YP_040099.1 704409 D 282458 CDS YP_040100.1 49482876 2860665 705242..706246 1 NC_002952.2 Previously sequenced as Staphylococcus aureus ferrichrome transport permease FhuB TR:Q9X664 (EMBL:AF132117) (341 aa) fasta scores: E(): 7.1e-110, 98.802% id in 334 aa. Similar to Bacillus halodurans ferrichrome ABC transporter FhuB TR:Q9KDX8 (EMBL:AP001510) (338 aa) fasta scores: E(): 1.3e-46, 40.615% id in 325 aa. CDS is 6 amino acids shorter at the N-termimus than the previously sequenced protein; ferrichrome transport permease 706246 fhuB 2860665 fhuB Staphylococcus aureus subsp. aureus MRSA252 ferrichrome transport permease YP_040100.1 705242 D 282458 CDS YP_040101.1 49482877 2860666 706243..707259 1 NC_002952.2 Similar to Staphylococcus aureus ferrichrome transport permease FhuD TR:Q9X662 (EMBL:AF132117) (338 aa) fasta scores: E(): 6.7e-123, 99.112% id in 338 aa, and to Bacillus halodurans ferrichrome ABC transporter FhuG TR:Q9KDX9 (EMBL:AP001510) (334 aa) fasta scores: E(): 1e-52, 43.114% id in 334 aa; ferrichrome transport permease 707259 fhuD 2860666 fhuD Staphylococcus aureus subsp. aureus MRSA252 ferrichrome transport permease YP_040101.1 706243 D 282458 CDS YP_040102.1 49482878 2861627 707493..708461 1 NC_002952.2 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 708461 2861627 SAR0660 Staphylococcus aureus subsp. aureus MRSA252 dihydroxyacetone kinase subunit DhaK YP_040102.1 707493 D 282458 CDS YP_040103.1 49482879 2861628 708503..709087 1 NC_002952.2 Similar to the C-terminus of Citrobacter freundii dihydroxyacetone kinase DhaK SW:DAK_CITFR (P45510) (552 aa) fasta scores: E(): 0.00012, 28.000% id in 200 aa, and to Bacillus halodurans BH3396 TR:Q9K7G5 (EMBL:AP001518) (196 aa) fasta scores: E(): 1.7e-21, 42.857% id in 189 aa. Possible subunit of a larger protein; dihydroxyacetone kinase 709087 2861628 SAR0661 Staphylococcus aureus subsp. aureus MRSA252 dihydroxyacetone kinase YP_040103.1 708503 D 282458 CDS YP_040104.1 49482880 2861629 709080..709442 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YceJ TR:Q9CIV6 (EMBL:AE006262) (123 aa) fasta scores: E(): 5.3e-12, 40.741% id in 108 aa, and to Bacillus halodurans hypothetical protein BH3395 TR:Q9K7G6 (EMBL:AP001518) (128 aa) fasta scores: E(): 1.8e-09, 35.652% id in 115 aa; PTS system mannnose-specific transporter subunit IIA 709442 2861629 SAR0662 Staphylococcus aureus subsp. aureus MRSA252 PTS system mannnose-specific transporter subunit IIA YP_040104.1 709080 D 282458 CDS YP_040105.1 49482881 2861630 709558..710055 1 NC_002952.2 hypothetical protein 710055 2861630 SAR0663 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040105.1 709558 D 282458 CDS YP_040106.1 49482882 2861631 710511..711578 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkvI TR:O31674 (EMBL:Z99111) (347 aa) fasta scores: E(): 7.7e-23, 27.246% id in 345 aa, and to Bacillus halodurans hypothetical protein BH4053 TR:Q9K5N5 (EMBL:AP001520) (341 aa) fasta scores: E(): 3.6e-06, 20.420% id in 333 aa; hypothetical protein 711578 2861631 SAR0664 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040106.1 710511 D 282458 CDS YP_040107.1 49482883 2861632 711729..712772 1 NC_002952.2 Internal region of the CDS is similar to an internal region of Rhodococcus sp heroin esterase Her TR:O06441 (EMBL:U70619) (322 aa) fasta scores: E(): 1.3e-12, 28.017% id in 232 aa, and the C-terminal region of Clostridium perfringens lipase LipA TR:Q9XDU5 (EMBL:AB028629) (311 aa) fasta scores: E(): 6e-34, 39.163% id in 263 aa; esterase 712772 2861632 SAR0665 Staphylococcus aureus subsp. aureus MRSA252 esterase YP_040107.1 711729 D 282458 CDS YP_040108.1 49482884 2861633 713100..713528 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Ureaplasma parvum pseudouridine synthase (uracil hydrolase) SfhB TR:Q9PR31 (EMBL:AE002111) (315 aa) fasta scores: E(): 5.7, 29.545% id in 132 aa; hypothetical protein 713528 2861633 SAR0666 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040108.1 713100 D 282458 CDS YP_040109.1 49482885 2861634 complement(713726..714232) 1 NC_002952.2 Similar to Vibrio cholerae acetyltransferase VCA0436 TR:Q9KMC6 (EMBL:AE004377) (171 aa) fasta scores: E(): 1.8e-12, 26.829% id in 164 aa, and to Lactococcus lactis hypothetical protein YlaG TR:Q9CGJ5 (EMBL:AE006342) (162 aa) fasta scores: E(): 4.7e-12, 30.723% id in 166 aa; hypothetical protein 714232 2861634 SAR0667 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040109.1 713726 R 282458 CDS YP_040110.1 49482886 2861635 714345..715268 1 NC_002952.2 Poor database matches. N-terminal region is similar to Staphylococcus epidermidis oxidoreductase EciO TR:O54218 (EMBL:Y14023) (247 aa) fasta scores: E(): 1.1, 21.116% id in 251 aa, and to N-terminal region of Rhizobium loti UDP-glucose 4-epimerase MLR8551 TR:BAB54411 (EMBL:AP003014) (310 aa) fasta scores: E(): 6.5, 21.875% id in 256 aa; hypothetical protein 715268 2861635 SAR0668 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040110.1 714345 D 282458 CDS YP_040111.1 49482887 2861636 715284..715958 1 NC_002952.2 Probable two-component regulatory system family, response regulator protein. Similar to Bacillus halodurans two-component response regulator BH3911 TR:Q9K621 (EMBL:AP001520) (231 aa) fasta scores: E(): 9.9e-52, 56.951% id in 223 aa, and to Bacillus subtilis signal transduction regulator YtsA TR:O34951 (EMBL:AF008220) (231 aa) fasta scores: E(): 1.6e-49, 55.605% id in 223 aa; response regulator protein 715958 2861636 SAR0669 Staphylococcus aureus subsp. aureus MRSA252 response regulator protein YP_040111.1 715284 D 282458 CDS YP_040112.1 49482888 2861637 715951..716991 1 NC_002952.2 Probable two-component regulatory system family, sensor kinase. Similar to Bacillus halodurans two-component sensor histidine kinase BH3912 TR:Q9K620 (EMBL:AP001520) (334 aa) fasta scores: E(): 4.2e-38, 37.879% id in 330 aa, and to Bacillus subtilis signal transduction protein kinase YtsB TR:O35044 (EMBL:AF008220) (334 aa) fasta scores: E(): 3.1e-34, 34.848% id in 330 aa; sensor histidine kinase 716991 2861637 SAR0670 Staphylococcus aureus subsp. aureus MRSA252 sensor histidine kinase YP_040112.1 715951 D 282458 CDS YP_040113.1 49482889 2861638 717138..717899 1 NC_002952.2 Similar to Staphylococcus aureus ABC transporter, up-regulated in vancomycin-resistant strains, VraF TR:Q9KWJ5 (EMBL:AB035453) (253 aa) fasta scores: E(): 4.3e-73, 92.885% id in 253 aa, and to Streptococcus salivarius salivaricin A ABC transporter SalX TR:Q9F444 (EMBL:AY005472) (245 aa) fasta scores: E(): 4e-29, 45.902% id in 244 aa. Similar to SAR2781, 63.200% identity (63.454% ungapped) in 250 aa overlap; ABC transporter 717899 2861638 SAR0671 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter YP_040113.1 717138 D 282458 CDS YP_040114.1 49482890 2861639 717889..719778 1 NC_002952.2 Similar to Staphylococcus aureus ABC transporter, up-regulated in vancomycin-resistant strains, VraE TR:Q9KWJ6 (EMBL:AB035452) (626 aa) fasta scores: E(): 6.2e-80, 38.959% id in 634 aa, and to Bacillus subtilis ABC transporter permease YtsD TR:O34741 (EMBL:AF008220) (646 aa) fasta scores: E(): 8.5e-32, 31.846% id in 650 aa; ABC transporter permease 719778 2861639 SAR0672 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_040114.1 717889 D 282458 CDS YP_040115.1 49482891 2861640 720394..721011 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkaA SW:YKAA_BACSU (O34454) (205 aa) fasta scores: E(): 3.2e-31, 46.829% id in 205 aa, and to Deinococcus radiodurans conserved hypothetical protein DR0924 TR:Q9RVU8 (EMBL:AE001945) (212 aa) fasta scores: E(): 5.8e-10, 25.481% id in 208 aa; hypothetical protein 721011 2861640 SAR0673 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040115.1 720394 D 282458 CDS YP_040116.1 49482892 2859727 721027..722034 1 NC_002952.2 Similar to Bacillus subtilis probable low-affinity inorganic phosphate transporter Pit SW:PIT_BACSU (O34436) (328 aa) fasta scores: E(): 5.6e-79, 68.932% id in 309 aa, and to Streptomyces coelicolor phosphate transport protein PitH TR:Q9KZW3 (EMBL:AL353816) (332 aa) fasta scores: E(): 3.3e-55, 45.045% id in 333 aa; phosphate transport protein 722034 2859727 SAR0674 Staphylococcus aureus subsp. aureus MRSA252 phosphate transport protein YP_040116.1 721027 D 282458 CDS YP_040117.1 49482893 2859723 complement(722621..723418) 1 NC_002952.2 Similar to Staphylococcus carnosus secreted protein precursor SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 1.2e-19, 35.816% id in 282 aa, and to Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 2.4e-18, 36.330% id in 267 aa; hypothetical protein 723418 2859723 SAR0675 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040117.1 722621 R 282458 CDS YP_040118.1 49482894 2861643 723779..724423 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YetJ TR:O31539 (EMBL:Z99107) (214 aa) fasta scores: E(): 1.3e-07, 22.886% id in 201 aa, and to Helicobacter pylori J99 hypothetical protein JHP0854 TR:Q9ZKT1 (EMBL:AE001515) (230 aa) fasta scores: E(): 1.3e-07, 22.488% id in 209 aa; hypothetical protein 724423 2861643 SAR0676 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040118.1 723779 D 282458 CDS YP_040119.1 49482895 2861645 727339..727764 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus staphylococcal accessory regulator A homologue SarR TR:Q9F0R1 (EMBL:AF207701) (115 aa) fasta scores: E(): 3.3, 21.359% id in 103 aa; hypothetical protein 727764 2861645 SAR0679 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040119.1 727339 D 282458 CDS YP_040120.1 49482896 2861646 727954..728670 1 NC_002952.2 Similar to Bacillus halodurans BH3259 TR:Q9K7V0 (EMBL:AP001518) (239 aa) fasta scores: E(): 3.6e-63, 74.262% id in 237 aa, and to Bacillus subtilis hypothetical protein YeeI SW:YEEI_BACSU (O31509) (240 aa) fasta scores: E(): 9.9e-61, 72.689% id in 238 aa; hypothetical protein 728670 2861646 SAR0680 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040120.1 727954 D 282458 CDS YP_040121.1 49482897 2861647 728670..729143 1 NC_002952.2 Similar to Synechocystis sp hypothetical protein SLL1188 TR:P72845 (EMBL:D90901) (164 aa) fasta scores: E(): 6.5e-24, 42.405% id in 158 aa, and to Streptococcus pneumoniae conserved hypothetical protein SP2081 TR:AAK76141 (EMBL:AE007497) (153 aa) fasta scores: E(): 2e-25, 48.000% id in 150 aa; hypothetical protein 729143 2861647 SAR0681 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040121.1 728670 D 282458 CDS YP_040122.1 49482898 2861648 729496..730140 1 NC_002952.2 N-terminal region is similar to Pyrococcus horikoshii hypothetical protein PH1613 ph1613 TR:O59236 (EMBL:AP000006) (166 aa) fasta scores: E(): 4.9e-06, 29.070% id in 172 aa, and to Pyrococcus abyssi hypothetical protein PAB0381 TR:Q9V175 (EMBL:AJ248284) (171 aa) fasta scores: E(): 3.5e-05, 29.609% id in 179 aa; hypothetical protein 730140 2861648 SAR0682 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040122.1 729496 D 282458 CDS YP_040123.1 49482899 2861649 730258..731124 1 NC_002952.2 N-terminus is similar to the N-terminal region of Erwinia carotovora hydrogen peroxide-inducible genes activator OxyR SW:OXYR_ERWCA (P71318) (302 aa) fasta scores: E(): 2.5e-09, 23.577% id in 246 aa. Full length CDS is similar to Bacillus halodurans transcriptional regulator BH1787 TR:Q9KBY7 (EMBL:AP001513) (280 aa) fasta scores: E(): 1.7e-33, 35.125% id in 279 aa; LysR family regulatory protein 731124 2861649 SAR0683 Staphylococcus aureus subsp. aureus MRSA252 LysR family regulatory protein YP_040123.1 730258 D 282458 CDS YP_040124.1 49482900 2861650 731256..732476 1 NC_002952.2 Similar to Escherichia coli sugar efflux transporter C SetC SW:SETC_ECOLI (P31436) (394 aa) fasta scores: E(): 7.1e-26, 27.559% id in 381 aa, and to Erwinia chrysanthemi sugar efflux transporter SotA SW:SOTA_ERWCH (Q9S3K0) (393 aa) fasta scores: E(): 1.4e-25, 29.759% id in 373 aa; sugar efflux transporter 732476 2861650 SAR0684 Staphylococcus aureus subsp. aureus MRSA252 sugar efflux transporter YP_040124.1 731256 D 282458 CDS YP_040125.1 49482901 2861653 734448..735122 1 NC_002952.2 Similar to Staphylococcus aureus plasmid (pSK41) transposase TnpG TR:Q53697 (EMBL:X53951) (224 aa) fasta scores: E(): 4.8e-79, 88.839% id in 224 aa, and to Staphylococcus epidermidis plasmid (pSK818) insertion sequence IS257(818C) transposase Tnp TR:P97218 (EMBL:U40386) (224 aa) fasta scores: E(): 1.8e-78, 88.839% id in 224 aa; transposase 735122 2861653 SAR0687 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040125.1 734448 D 282458 CDS YP_040126.1 49482902 2859765 complement(735157..735369) 1 NC_002952.2 hypothetical protein 735369 2859765 SAR0688 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040126.1 735157 R 282458 CDS YP_040127.1 49482903 2859867 736085..736399 1 NC_002952.2 Highly similar to Staphylococcus aureus plasmid pI258 arsenical resistance operon repressor ArsR SW:ARSR_STAAU (P30338) (104 aa) fasta scores: E(): 2.9e-40, 99.038% id in 104 aa, and to Staphylococcus xylosus plasmid pSX267 arsenical resistance operon repressor ArsR SW:ARSR_STAXY (Q01256) (104 aa) fasta scores: E(): 5.9e-34, 85.577% id in 104 aa. Similar to SAR1855, 75.000% identity (75.000% ungapped) in 104 aa overlap; arsenical resistance operon repressor 1 736399 arsR1 2859867 arsR1 Staphylococcus aureus subsp. aureus MRSA252 arsenical resistance operon repressor 1 YP_040127.1 736085 D 282458 CDS YP_040128.1 49482904 2859864 736399..737688 1 NC_002952.2 Highly similar to Staphylococcus aureus arsenical pump membrane protein ArsB SW:ARSB_STAAU (P30329) (429 aa) fasta scores: E(): 2e-142, 99.301% id in 429 aa, and to Staphylococcus xylosus arsenical pump membrane protein ArsB SW:ARSB_STAXY (Q01255) (429 aa) fasta scores: E(): 1.5e-139, 96.737% id in 429 aa. Similar to SAR1856, 79.254% identity (79.254% ungapped) in 429 aa overlap; arsenical pump membrane protein 1 737688 arsB1 2859864 arsB1 Staphylococcus aureus subsp. aureus MRSA252 arsenical pump membrane protein 1 YP_040128.1 736399 D 282458 CDS YP_040129.1 49482905 2859866 737706..738101 1 NC_002952.2 catalyzes the reduction of arsenate to arsenite; also can dephosphorylate tyrosine phosphorylated proteins, aryl phosphates, and acyl phosphates; arsenate reductase 738101 arsC 2859866 arsC Staphylococcus aureus subsp. aureus MRSA252 arsenate reductase YP_040129.1 737706 D 282458 CDS YP_040130.1 49482906 2859767 738308..738466 1 NC_002952.2 Similar to Mycoplasma pulmonis hypothetical protein MYPU_3400 TR:CAC13513 (EMBL:AL445564) (49 aa) fasta scores: E(): 1.6, 36.957% id in 46 aa; hypothetical protein 738466 2859767 SAR0693 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040130.1 738308 D 282458 CDS YP_040131.1 49482907 2859768 738481..738774 1 NC_002952.2 Similar to Lactococcus lactis lactococcin 972 precursor LclA TR:O86283 (EMBL:AJ002203) (91 aa) fasta scores: E(): 0.019, 30.769% id in 78 aa, and to the N-terminal region of Bacillus subtilis endopeptidase precursor LytF TR:O07532 (EMBL:Y14079) (488 aa) fasta scores: E(): 3.1, 36.471% id in 85 aa; hypothetical protein 738774 2859768 SAR0694 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040131.1 738481 D 282458 CDS YP_040132.1 49482908 2859769 738849..740783 1 NC_002952.2 Similar to Lactococcus lactis plasmid pBL1 hypothetical lactococcin 972 immunity protein LclB TR:Q9L651 (EMBL:AF242367) (648 aa) fasta scores: E(): 1.4e-14, 22.356% id in 662 aa, and to Lactococcus lactis hypothetical protein YujE TR:Q9CE29 (EMBL:AE006431) (660 aa) fasta scores: E(): 5.4e-08, 19.288% id in 674 aa; hypothetical protein 740783 2859769 SAR0695 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040132.1 738849 D 282458 CDS YP_040133.1 49482909 2859770 740787..741098 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YxeA SW:YXEA_BACSU (P54940) (115 aa) fasta scores: E(): 0.0026, 30.841% id in 107 aa; hypothetical protein 741098 2859770 SAR0696 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040133.1 740787 D 282458 CDS YP_040134.1 49482910 2859771 741110..741736 1 NC_002952.2 Similar to Lactococcus lactis hypothetical ATP binding protein TR:Q9L650 (EMBL:AF242367) (207 aa) fasta scores: E(): 1e-26, 49.758% id in 207 aa, and to Streptococcus pneumoniae hypothetical protein TR:Q9ZHB1 (EMBL:AF068902) (213 aa) fasta scores: E(): 4.3e-25, 45.238% id in 210 aa; ABC transporter ATP-binding protein 741736 2859771 SAR0697 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040134.1 741110 D 282458 CDS YP_040135.1 49482911 2859772 742098..743744 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 6.9e-199, 99.270% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 2.8e-99, 52.115% id in 520 aa; transposase 743744 2859772 SAR0698 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040135.1 742098 D 282458 CDS YP_040136.1 49482912 2859774 complement(745289..745432) 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 745432 2859774 SAR0702 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040136.1 745289 R 282458 CDS YP_040137.1 49482913 2859775 745474..746334 1 NC_002952.2 Similar to Staphylococcus epidermidis plasmid pSK639 replication initiation protein Orf287 TR:P95741 (EMBL:U40259) (287 aa) fasta scores: E(): 5.7e-76, 76.224% id in 286 aa, and to Lactobacillus acidophilus plasmid pLA103 replication protein RepA TR:Q52180 (EMBL:D55703) (282 aa) fasta scores: E(): 1.2e-28, 36.842% id in 285 aa; plasmid replication initiation protein 746334 2859775 SAR0703 Staphylococcus aureus subsp. aureus MRSA252 plasmid replication initiation protein YP_040137.1 745474 D 282458 CDS YP_040138.1 49482914 2859776 746421..746762 1 NC_002952.2 Similar to Lactococcus lactis transcriptional regulator YabB TR:Q9CJI6 (EMBL:AE006240) (107 aa) fasta scores: E(): 6.2e-09, 35.714% id in 112 aa, and to the N-terminal region of Streptococcus pyogenes hypothetical protein SPY1834 TR:Q99Y76 (EMBL:AE006610) (195 aa) fasta scores: E(): 3.2e-07, 34.259% id in 108 aa; DNA-binding protein 746762 2859776 SAR0704 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_040138.1 746421 D 282458 CDS YP_040139.1 49482915 2859777 746836..746967 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 746967 2859777 SAR0705 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040139.1 746836 D 282458 CDS YP_040140.1 49482916 2859778 complement(746977..747081) 1 NC_002952.2 No significant database matches. Similar to SAR1888, 50.000% identity (50.000% ungapped) in 28 aa overlap, and to SAR0716, 55.556% identity (55.556% ungapped) in 27 aa overlap; hypothetical protein 747081 2859778 SAR0706 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040140.1 746977 R 282458 CDS YP_040141.1 49482917 2859780 748482..748598 1 NC_002952.2 hypothetical protein 748598 2859780 SAR0710 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040141.1 748482 D 282458 CDS YP_040142.1 49482918 2859783 750428..750637 1 NC_002952.2 Poor database matches. Similar to internal region of Campylobacter jejuni arsenical pump membrane protein ArsB TR:Q9PNA8 (EMBL:AL139077) (428 aa) fasta scores: E(): 7.1, 33.333% id in 66 aa; hypothetical protein 750637 2859783 SAR0714 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040142.1 750428 D 282458 CDS YP_040143.1 49482919 2859784 complement(750819..751142) 1 NC_002952.2 Poor database matches Similar to the C-terminal regions of Streptomyces coelicolor hypothetical protein SC5G9.13c TR:Q9RL13 (EMBL:AL117385) (122 aa) fasta scores: E(): 0.97, 28.571% id in 91 aa, and Rhizobium loti hypothetical protein MLR1105 TR:BAB48553 (EMBL:AP002996) (210 aa) fasta scores: E(): 1.6, 29.885% id in 87 aa; hypothetical protein 751142 2859784 SAR0715 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040143.1 750819 R 282458 CDS YP_040144.1 49482920 2859785 751371..751463 1 NC_002952.2 Nosignificant database matches. Similar to SAR1888, 72.414% identity (72.414% ungapped) in 29 aa overlap, and to SAR0706, 55.556% identity (55.556% ungapped) in 27 aa overlap; hypothetical protein 751463 2859785 SAR0716 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040144.1 751371 D 282458 CDS YP_040145.1 49482921 2859786 complement(751765..752586) 1 NC_002952.2 Similar to Rhodospirillum rubrum rubisco operon transcriptional regulator CbbR SW:CBBR_RHORU (P52595) (298 aa) fasta scores: E(): 1.2e-07, 26.087% id in 276 aa, and to Staphylococcus xylosus hypothetical transcriptional regulator SW:YLAC_STAXY (O33812) (270 aa) fasta scores: E(): 8.9e-68, 70.943% id in 265 aa; LysR family regulatory protein 752586 2859786 SAR0717 Staphylococcus aureus subsp. aureus MRSA252 LysR family regulatory protein YP_040145.1 751765 R 282458 CDS YP_040146.1 49482922 2859787 752711..753706 1 NC_002952.2 Similar to Escherichia coli hypothetical protein YeiH SW:YEIH_ECOLI (P33019) (349 aa) fasta scores: E(): 5.7e-28, 31.429% id in 315 aa, and to Rhizobium loti hypothetical protein MLR2225 TR:BAB49407 (EMBL:AP002999) (325 aa) fasta scores: E(): 1.1e-26, 27.900% id in 319 aa. Similar to SAR0338, 68.085% identity (68.085% ungapped) in 329 aa overlap; hypothetical protein 753706 2859787 SAR0718 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040146.1 752711 D 282458 CDS YP_040147.1 49482923 2859788 complement(754041..754616) 1 NC_002952.2 Similar to Staphylococcus aureus plasmid pI9789 transposon Tn552 resolvase TnpR SW:BINL_STAAU (P18358) (197 aa) fasta scores: E(): 1e-66, 93.194% id in 191 aa, and to Staphylococcus epidermidis plasmid pST6 resolvase/integrase BinR TR:AAK38454 (EMBL:AY028779) (192 aa) fasta scores: E(): 2.5e-66, 92.708% id in 192 aa. Similar to SAR1828, 94.764% identity (94.764% ungapped) in 191 aa overlap; resolvase 754616 2859788 SAR0719 Staphylococcus aureus subsp. aureus MRSA252 resolvase YP_040147.1 754041 R 282458 CDS YP_040148.1 49482924 2859789 754883..756928 1 NC_002952.2 Similar to Streptococcus mutans copper exporting P-type ATPase CopA TR:Q9F682 (EMBL:AF296446) (742 aa) fasta scores: E(): 1.2e-66, 34.431% id in 668 aa, and to Enterococcus hirae probable copper exporting ATPase B CopB SW:COPB_ENTHR (P05425) (745 aa) fasta scores: E(): 2.2e-135, 57.122% id in 681 aa; cation exporting ATPase 756928 2859789 SAR0720 Staphylococcus aureus subsp. aureus MRSA252 cation exporting ATPase YP_040148.1 754883 D 282458 CDS YP_040149.1 49482925 2859790 756943..758376 1 NC_002952.2 Similar to Campylobacter jejuni periplasmic oxidoreductase CJ1516 TR:Q9PME8 (EMBL:AL139078) (513 aa) fasta scores: E(): 9.6e-22, 31.673% id in 502 aa, and to Escherichia coli probable blue-copper protein precursor YacK SW:YACK_ECOLI (P36649) (516 aa) fasta scores: E(): 2.8e-30, 35.931% id in 462 aa; multicopper oxidase 758376 2859790 SAR0721 Staphylococcus aureus subsp. aureus MRSA252 multicopper oxidase YP_040149.1 756943 D 282458 CDS YP_040150.1 49482926 2859791 complement(758443..760089) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 8.5e-195, 97.810% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 8.1e-99, 52.115% id in 520 aa; transposase 760089 2859791 SAR0722 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040150.1 758443 R 282458 CDS YP_040151.1 49482927 2859821 complement(760452..762632) 1 NC_002952.2 Similar to Staphylococcus aureus plasmid pI258 probable cadmium-transporting ATPase CadA SW:CADA_STAAU (P20021) (727 aa) fasta scores: E(): 0, 91.586% id in 725 aa, and to Bacillus firmus probable cadmium-transporting ATPase CadA SW:CADA_BACFI (P30336) (723 aa) fasta scores: E(): 1.5e-213, 81.354% id in 724 aa; cadmium-transporting ATPase 762632 cadA 2859821 cadA Staphylococcus aureus subsp. aureus MRSA252 cadmium-transporting ATPase YP_040151.1 760452 R 282458 CDS YP_040152.1 49482928 2860182 complement(762625..762990) 1 NC_002952.2 Similar to Staphylococcus aureus cadmium resistance protein CadC SW:CADF_STAAU (P37374) (121 aa) fasta scores: E(): 1.6e-43, 98.347% id in 121 aa, and to Listeria monocytogenes plasmid pLm74 cadmium efflux system accessory protein CadC SW:CADC_LISMO (Q56405) (119 aa) fasta scores: E(): 1.1e-19, 53.571% id in 112 aa; cadmium efflux system accessory protein 762990 cadC 2860182 cadC Staphylococcus aureus subsp. aureus MRSA252 cadmium efflux system accessory protein YP_040152.1 762625 R 282458 CDS YP_040153.1 49482929 2859792 complement(763228..763605) 1 NC_002952.2 Similar to Staphylococcus aureus transposase C of transposon Tn554 TR:BAB47607 (EMBL:AB037671) (125 aa) fasta scores: E(): 2e-36, 98.400% id in 125 aa; Tn554 transposase C 763605 2859792 SAR0725 Staphylococcus aureus subsp. aureus MRSA252 Tn554 transposase C YP_040153.1 763228 R 282458 CDS YP_040154.1 49482930 2859793 763700..764374 1 NC_002952.2 Similar to Staphylococcus aureus transposase for insertion sequence-like element IS431mec TR:BAA82238 (EMBL:D86934) (224 aa) fasta scores: E(): 2.4e-78, 88.393% id in 224 aa, and to Staphylococcus epidermidis plasmid pSK818 transposase Tnp TR:P97218 (EMBL:U40386) (224 aa) fasta scores: E(): 1.8e-78, 88.839% id in 224 aa; transposase 764374 2859793 SAR0726 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040154.1 763700 D 282458 CDS YP_040155.1 49482931 2859794 complement(765037..765726) 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans BH0407 TR:Q9KFS0 (EMBL:AP001508) (228 aa) fasta scores: E(): 4.5e-05, 23.445% id in 209 aa; hypothetical protein 765726 2859794 SAR0728 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040155.1 765037 R 282458 CDS YP_040156.1 49482932 2859795 765853..766296 1 NC_002952.2 C-terminus is similar to the C-terminal regions of Acinetobacter sp aminoglycoside resistance protein Aac(6')-Ik TR:Q44246 (EMBL:L29510) (145 aa) fasta scores: E(): 0.021, 31.373% id in 102 aa, and to Vibrio cholerae acetyltransferase VC1341 TR:Q9KSB7 (EMBL:AE004214) (158 aa) fasta scores: E(): 0.042, 26.357% id in 129 aa; acetyltransferase 766296 2859795 SAR0729 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_040156.1 765853 D 282458 CDS YP_040157.1 49482933 2859796 766363..766752 1 NC_002952.2 No significant database matches. Lysine and aspartic acid rich protein, 27.1% and 15.5% of the total amino acid content respectively. Contains coiled-coiled domain, residues 29 to 57; hypothetical protein 766752 2859796 SAR0730 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040157.1 766363 D 282458 CDS YP_040158.1 49482934 2859797 766890..767189 1 NC_002952.2 hypothetical protein 767189 2859797 SAR0731 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040158.1 766890 D 282458 CDS YP_040159.1 49482935 2859798 767269..767811 1 NC_002952.2 Similar to Proteus mirabilis acetyl transferase Pat TR:O86434 (EMBL:AJ000084) (185 aa) fasta scores: E(): 6.4e-19, 42.529% id in 174 aa, and to Streptomyces coelicolor acetyltranferase SC5C11.04c TR:Q9L168 (EMBL:AL158060) (183 aa) fasta scores: E(): 3.7e-16, 37.853% id in 177 aa; acetyltransferase 767811 2859798 SAR0732 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_040159.1 767269 D 282458 CDS YP_040160.1 49482936 2859799 complement(767906..768472) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3084 TR:Q9K8C2 (EMBL:AP001517) (187 aa) fasta scores: E(): 1e-33, 49.189% id in 185 aa, and to Bacillus subtilis hypothetical protein YvdD TR:O06986 (EMBL:Z94043) (191 aa) fasta scores: E(): 2.1e-31, 48.603% id in 179 aa; hypothetical protein 768472 2859799 SAR0733 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040160.1 767906 R 282458 CDS YP_040161.1 49482937 2861398 complement(768474..768932) 1 NC_002952.2 Similar to Listeria monocytogenes hypothetical protein SW:YP17_LISMO (P52309) (149 aa) fasta scores: E(): 9.4e-14, 34.752% id in 141 aa, and to Bacillus halodurans hypothetical protein BH1374 TR:Q9KD45 (EMBL:AP001511) (157 aa) fasta scores: E(): 2.2e-11, 32.192% id in 146 aa; hypothetical protein 768932 2861398 SAR0734 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040161.1 768474 R 282458 CDS YP_040162.1 49482938 2861399 complement(768935..769618) 1 NC_002952.2 No significant database matches. CDS is lysine rich, 23.3% of the total amino acid content; hypothetical protein 769618 2861399 SAR0735 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040162.1 768935 R 282458 CDS YP_040163.1 49482939 2859884 complement(769790..770665) 1 NC_002952.2 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 770665 uppP 2859884 uppP Staphylococcus aureus subsp. aureus MRSA252 UDP pyrophosphate phosphatase YP_040163.1 769790 R 282458 CDS YP_040164.1 49482940 2861400 770884..772515 1 NC_002952.2 Similar to Escherichia coli transport ATP-binding protein CydD SW:CYDD_ECOLI (P29018) (588 aa) fasta scores: E(): 3.6e-22, 28.799% id in 566 aa, and to Bacillus subtilis transport ATP-binding protein CydC SW:CYDC_BACSU (P94366) (567 aa) fasta scores: E(): 2.4e-28, 27.839% id in 546 aa; ABC transporter ATP-binding protein 772515 2861400 SAR0737 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040164.1 770884 D 282458 CDS YP_040165.1 49482941 2861401 772512..774185 1 NC_002952.2 Similar to Escherichia coli transport ATP-binding protein CydC SW:CYDC_ECOLI (P23886) (573 aa) fasta scores: E(): 3.4e-33, 30.195% id in 563 aa, and to Bacillus halodurans ABC transporter ATP-binding protein BH3972 TR:Q9K5W5 (EMBL:AP001520) (575 aa) fasta scores: E(): 6.1e-48, 32.491% id in 554 aa; ABC transporter ATP-binding protein 774185 2861401 SAR0738 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040165.1 772512 D 282458 CDS YP_040166.1 49482942 2861402 complement(774312..774755) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkmA TR:O34777 (EMBL:AJ002571) (147 aa) fasta scores: E(): 2e-14, 36.879% id in 141 aa, and to Streptomyces coelicolor regulatory protein SCE50.15 TR:Q9L048 (EMBL:AL163672) (168 aa) fasta scores: E(): 3.5e-14, 39.007% id in 141 aa; MarR family regulatory protein 774755 2861402 SAR0739 Staphylococcus aureus subsp. aureus MRSA252 MarR family regulatory protein YP_040166.1 774312 R 282458 CDS YP_040167.1 49482943 2861403 774982..775908 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0366 TR:Q9KFV5 (EMBL:AP001508) (311 aa) fasta scores: E(): 4.7e-27, 31.190% id in 311 aa, and to Aquifex aeolicus cobalamin synthesis related protein CobW TR:O66539 (EMBL:AE000675) (292 aa) fasta scores: E(): 1.6e-16, 29.682% id in 283 aa; cobalamin synthesis protein 775908 2861403 SAR0740 Staphylococcus aureus subsp. aureus MRSA252 cobalamin synthesis protein YP_040167.1 774982 D 282458 CDS YP_040168.1 49482944 2861404 776011..776919 1 NC_002952.2 Similar to Bacillus subtilis hypothetical oxidoreductase YcsN SW:YCSN_BACSU (P42972) (300 aa) fasta scores: E(): 4e-51, 47.195% id in 303 aa, and to Escherichia coli hypothetical oxidoreductase YdhF SW:YDHF_ECOLI (P76187) (298 aa) fasta scores: E(): 1.1e-44, 43.151% id in 292 aa; aldo/keto reductase 776919 2861404 SAR0741 Staphylococcus aureus subsp. aureus MRSA252 aldo/keto reductase YP_040168.1 776011 D 282458 CDS YP_040169.1 49482945 2861405 776954..777241 1 NC_002952.2 Poor database matches. Similar to an internal region of Methanococcus jannaschii hypothetical protein MJ0420 SW:Y420_METJA (Q57863) (380 aa) fasta scores: E(): 0.11, 32.143% id in 84 aa; hypothetical protein 777241 2861405 SAR0742 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040169.1 776954 D 282458 CDS YP_040170.1 49482946 2861406 777524..779077 1 NC_002952.2 Similar to Escherichia coli citrate carrier protein CitT SW:CITT_ECOLI (P77405) (487 aa) fasta scores: E(): 1.1e-26, 23.400% id in 500 aa, and to Alcaligenes eutrophus membrane protein SW:MEMP_ALCEU (Q07252) (513 aa) fasta scores: E(): 7.1e-75, 47.561% id in 492 aa; sodium:sulfate symporter protein 779077 2861406 SAR0743 Staphylococcus aureus subsp. aureus MRSA252 sodium:sulfate symporter protein YP_040170.1 777524 D 282458 CDS YP_040171.1 49482947 2861407 779163..780536 1 NC_002952.2 Similar to Escherichia coli deoxyribodipyrimidine photolyase PhrB SW:PHR_ECOLI (P00914) (472 aa) fasta scores: E(): 8.3e-37, 33.408% id in 449 aa, and to Streptococcus pyogenes deoxyribodipyrimidine photolyase Phr TR:Q99YX0 (EMBL:AE006584) (469 aa) fasta scores: E(): 1.8e-52, 34.402% id in 468 aa; DNA photolyase 780536 2861407 SAR0744 Staphylococcus aureus subsp. aureus MRSA252 DNA photolyase YP_040171.1 779163 D 282458 CDS YP_040172.1 49482948 2861408 complement(780691..780975) 1 NC_002952.2 Poor database matches. Similar to an internal region of Bacillus halodurans hypothetical protein BH0447 TR:Q9KFN2 (EMBL:AP001508) (247 aa) fasta scores: E(): 4.7, 20.225% id in 89 aa; hypothetical protein 780975 2861408 SAR0745 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040172.1 780691 R 282458 CDS YP_040173.1 49482949 2861409 complement(780972..781592) 1 NC_002952.2 Similar to Synechocystis sp hypothetical protein SLL0397 TR:Q55732 (EMBL:D64002) (217 aa) fasta scores: E(): 7.3e-07, 30.055% id in 183 aa, and to Treponema pallidum conserved hypothetical integral membrane protein TP0033 TR:O83076 (EMBL:AE001188) (203 aa) fasta scores: E(): 5.2e-05, 30.286% id in 175 aa; hypothetical protein 781592 2861409 SAR0746 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040173.1 780972 R 282458 CDS YP_040174.1 49482950 2861410 complement(781776..782198) 1 NC_002952.2 Similar to Archaeoglobus fulgidus hypothetical protein AF0104 TR:O30132 (EMBL:AE001099) (138 aa) fasta scores: E(): 9.2e-11, 34.127% id in 126 aa, and to Halobacterium sp hypothetical protein VNG2339C TR:Q9HMX7 (EMBL:AE005116) (139 aa) fasta scores: E(): 2.8e-08, 31.967% id in 122 aa; hypothetical protein 782198 2861410 SAR0747 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040174.1 781776 R 282458 CDS YP_040175.1 49482951 2859165 782414..783580 1 NC_002952.2 Highly similar to Staphylococcus aureus fluoroquinolone resistance protein NorA1199 TR:Q03325 (EMBL:M80252) (388 aa) fasta scores: E(): 6.4e-132, 96.134% id in 388 aa. Similar to Bacillus subtilis multidrug resistance protein 1 Bmr SW:BMR1_BACSU (P33449) (389 aa) fasta scores: E(): 1.7e-61, 44.125% id in 383 aa; fluoroquinolone resistance protein 783580 norA 2859165 norA Staphylococcus aureus subsp. aureus MRSA252 fluoroquinolone resistance protein YP_040175.1 782414 D 282458 CDS YP_040176.1 49482952 2861411 783865..784329 1 NC_002952.2 Poor database matches. Similar to Legionella pneumophila immunogenic protein TR:O32829 (EMBL:Z97066) (136 aa) fasta scores: E(): 3.6, 22.069% id in 145 aa; hypothetical protein 784329 2861411 SAR0749 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040176.1 783865 D 282458 CDS YP_040177.1 49482953 2861412 784503..784985 1 NC_002952.2 Similar to Enterococcus faecalis regulatory protein EbsC SW:EBSC_ENTFA (P36922) (164 aa) fasta scores: E(): 7.2e-21, 44.375% id in 160 aa, and to Bacillus subtilis hypothetical protein YjdI TR:O31650 (EMBL:Z99110) (159 aa) fasta scores: E(): 1.3e-21, 46.939% id in 147 aa; hypothetical protein 784985 2861412 SAR0750 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040177.1 784503 D 282458 CDS YP_040178.1 49482954 2861413 785238..785999 1 NC_002952.2 Similar to Escherichia coli aga operon transcriptional repressor AgaR SW:AGAR_ECOLI (P42902) (269 aa) fasta scores: E(): 1.2e-17, 28.571% id in 245 aa, and to Bacillus halodurans transcriptional repressor BH0826 TR:Q9KEM6 (EMBL:AP001510) (251 aa) fasta scores: E(): 5.3e-38, 45.082% id in 244 aa; DeoR ramily regulatory protein 785999 2861413 SAR0751 Staphylococcus aureus subsp. aureus MRSA252 DeoR ramily regulatory protein YP_040178.1 785238 D 282458 CDS YP_040179.1 49482955 2861414 785996..786916 1 NC_002952.2 Similar to Streptococcus mutans tagatose-6-phosphate kinase LacC SW:LACC_STRMU (P26421) (310 aa) fasta scores: E(): 1.8e-25, 35.789% id in 285 aa, and to Bacillus subtilis 1-phosphofructokinase FruK SW:K1PF_BACSU (O31714) (303 aa) fasta scores: E(): 7.7e-47, 46.865% id in 303 aa; phosphofructokinase 786916 2861414 SAR0752 Staphylococcus aureus subsp. aureus MRSA252 phosphofructokinase YP_040179.1 785996 D 282458 CDS YP_040180.1 49482956 2860682 786922..788880 1 NC_002952.2 Similar to Rhodobacter capsulatus PTS system, fructose-specific IIBC component FruA SW:PTFB_RHOCA (P23387) (578 aa) fasta scores: E(): 7.7e-66, 40.709% id in 592 aa. Previously sequenced as Staphylococcus aureus fructose specific permease FruA TR:Q9KWK0 (EMBL:AB035450) (646 aa) fasta scores: E(): 8.9e-218, 98.762% id in 646 aa; PTS transport system, fructose-specific IIABC component 788880 fruA 2860682 fruA Staphylococcus aureus subsp. aureus MRSA252 PTS transport system, fructose-specific IIABC component YP_040180.1 786922 D 282458 CDS YP_040181.1 49482957 2861415 789183..790364 1 NC_002952.2 Similar to Vibrio furnissii N-acetylglucosamine-6-phosphate deacetylase ManD SW:NAGA_VIBFU (P96166) (399 aa) fasta scores: E(): 3.9e-37, 36.000% id in 375 aa, and to Bacillus subtilis N-acetylglucosamine-6-phosphate deacetylase NagA SW:NAGA_BACSU (O34450) (396 aa) fasta scores: E(): 1.7e-56, 45.547% id in 393 aa; N-acetylglucosamine-6-phosphate deacetylase 790364 2861415 SAR0754 Staphylococcus aureus subsp. aureus MRSA252 N-acetylglucosamine-6-phosphate deacetylase YP_040181.1 789183 D 282458 CDS YP_040182.1 49482958 2861416 790585..791934 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhdP SW:YHDP_BACSU (O07585) (444 aa) fasta scores: E(): 1.3e-74, 47.529% id in 425 aa, and to Bacillus subtilis hypothetical protein YrkA SW:YRKA_BACSU (P54428) (434 aa) fasta scores: E(): 6.4e-69, 47.382% id in 401 aa; hypothetical protein 791934 2861416 SAR0755 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040182.1 790585 D 282458 CDS YP_040183.1 49482959 2861417 792148..792987 1 NC_002952.2 Similar to Trypanosoma brucei prostaglandin F synthase TR:Q9GV41 (EMBL:AB034727) (276 aa) fasta scores: E(): 3.9e-43, 47.547% id in 265 aa, and to Streptomyces coelicolor oxidoreductase SC4B5.01C TR:Q9ZBW7 (EMBL:AL034443) (277 aa) fasta scores: E(): 2.7e-50, 50.562% id in 267 aa; aldo/keto reductase 792987 2861417 SAR0756 Staphylococcus aureus subsp. aureus MRSA252 aldo/keto reductase YP_040183.1 792148 D 282458 CDS YP_040184.1 49482960 2861418 793119..794102 1 NC_002952.2 Similar to bacteriophage SfII bactoprenol glucosyl transferase GtrB SW:GTRB_BPSF2 (O21943) (309 aa) fasta scores: E(): 2.4e-42, 44.695% id in 311 aa, and to Bacillus subtilis hypothetical protein CsbB SW:CSBB_BACSU (Q45539) (329 aa) fasta scores: E(): 3.8e-61, 50.467% id in 321 aa; glucosyl transferase 794102 2861418 SAR0757 Staphylococcus aureus subsp. aureus MRSA252 glucosyl transferase YP_040184.1 793119 D 282458 CDS YP_040185.1 49482961 2861464 complement(794174..795229) 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Similar to Staphylococcus aureus exoproteins regulating histidine protein kinase SaeS TR:Q9S4L8 (EMBL:AF129010) (353 aa) fasta scores: E(): 1.6e-100, 88.952% id in 353 aa, and to Streptococcus pneumoniae histidine kinase Hk08 TR:Q9S1J1 (EMBL:AJ006397) (350 aa) fasta scores: E(): 2.6e-28, 34.097% id in 349 aa; histidine kinase 795229 saeS 2861464 saeS Staphylococcus aureus subsp. aureus MRSA252 histidine kinase YP_040185.1 794174 R 282458 CDS YP_040186.1 49482962 2861463 complement(795229..795915) 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Similar to Staphylococcus aureus exoproteins controlling response regulator SaeR TR:Q9S4L9 (EMBL:AF129010) (228 aa) fasta scores: E(): 2.1e-86, 98.246% id in 228 aa, and to Streptococcus pneumoniae response regulator Rr08 TR:Q9S1J2 (EMBL:AJ006397) (232 aa) fasta scores: E(): 4.9e-37, 46.256% id in 227 aa; response regulator protein 795915 saeR 2861463 saeR Staphylococcus aureus subsp. aureus MRSA252 response regulator protein YP_040186.1 795229 R 282458 CDS YP_040187.1 49482963 2861419 complement(795890..796363) 1 NC_002952.2 Poor database matches. N-terminus is similar to the N-terminal region of Bacillus halodurans hypothetical protein BH2253 TR:Q9KAN4 (EMBL:AP001514) (173 aa) fasta scores: E(): 3.3e-05, 32.479% id in 117 aa; hypothetical protein 796363 2861419 SAR0760 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040187.1 795890 R 282458 CDS YP_040188.1 49482964 2861420 complement(796705..797145) 1 NC_002952.2 Poor database matches Similar to the N-terminal region of Staphylococcus aureus pathogenicity island hypothetical protein Orf3 TR:Q9F0L5 (EMBL:AF217235) (170 aa) fasta scores: E(): 0.59, 28.276% id in 145 aa, and to an internal region of Drosophila melanogaster hypothetical protein CG5175 TR:Q9VEN4 (EMBL:AE003716) (566 aa) fasta scores: E(): 1.3, 30.986% id in 142 aa; hypothetical protein 797145 2861420 SAR0761 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040188.1 796705 R 282458 CDS YP_040189.1 49482965 2861421 complement(797425..798009) 1 NC_002952.2 Poor database matches. Similar to N-terminal regions of Campylobacter jejuni enterochelin uptake permease CeuC TR:Q9PMU6 (EMBL:AL139078) (312 aa) fasta scores: E(): 7.3, 26.042% id in 192 aa, and Thermoplasma volcanium hypothetical protein TVG0355256 TR:BAB59507 (EMBL:AP000992) (486 aa) fasta scores: E(): 8.8, 21.693% id in 189 aa; hypothetical protein 798009 2861421 SAR0762 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040189.1 797425 R 282458 CDS YP_040190.1 49482966 2861422 complement(798108..798821) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkvL TR:O31677 (EMBL:Z99111) (243 aa) fasta scores: E(): 4.6e-55, 62.551% id in 243 aa, and to Bacillus halodurans hypothetical protein BH2242 TR:Q9KAP5 (EMBL:AP001514) (236 aa) fasta scores: E(): 9.8e-53, 59.664% id in 238 aa; radical activating enzyme 798821 2861422 SAR0763 Staphylococcus aureus subsp. aureus MRSA252 radical activating enzyme YP_040190.1 798108 R 282458 CDS YP_040191.1 49482967 2861423 complement(798825..799244) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkvK TR:O31676 (EMBL:Z99111) (149 aa) fasta scores: E(): 5.9e-33, 60.284% id in 141 aa, and to Bacillus halodurans 6-pyruvoyl tetrahydrobiopterin synthase BH2243 TR:Q9KAP4 (EMBL:AP001514) (140 aa) fasta scores: E(): 1.2e-32, 58.394% id in 137 aa; 6-pyruvoyl-tetrahydropterin synthase 799244 2861423 SAR0764 Staphylococcus aureus subsp. aureus MRSA252 6-pyruvoyl-tetrahydropterin synthase YP_040191.1 798825 R 282458 CDS YP_040192.1 49482968 2860145 complement(799246..799914) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkvJ TR:O31675 (EMBL:Z99111) (219 aa) fasta scores: E(): 2.1e-62, 70.833% id in 216 aa, and to Bacillus halodurans aluminium resistance protein BH2244 TR:Q9KAP3 (EMBL:AP001514) (223 aa) fasta scores: E(): 5.1e-58, 68.545% id in 213 aa; hypothetical protein 799914 2860145 SAR0765 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040192.1 799246 R 282458 CDS YP_040193.1 49482969 2860146 800265..800858 1 NC_002952.2 Similar to the N-terminal region of Pichia angusta anthranilate synthase component II SW:TRPG_PICAN (P09575) (367 aa) fasta scores: E(): 3.6e-30, 42.784% id in 194 aa, and to Acinetobacter calcoaceticus anthranilate synthase component II TrpG SW:TRPG_ACICA (P00902) (194 aa) fasta scores: E(): 5.4e-29, 44.503% id in 191 aa; glutamine amidotransferase class-I protein 800858 2860146 SAR0766 Staphylococcus aureus subsp. aureus MRSA252 glutamine amidotransferase class-I protein YP_040193.1 800265 D 282458 CDS YP_040194.1 49482970 2861424 800842..801993 1 NC_002952.2 C-terminus is similar to the C-terminal region of Bacillus subtilis para-aminobenzoate synthase component I PabB SW:PABB_BACSU (P28820) (470 aa) fasta scores: E(): 1.2e-29, 39.216% id in 255 aa. Full length CDS is similar to the N-terminal region of Streptococcus pyogenes para-aminobenzoate synthetase PabB TR:Q99XW6 (EMBL:AE006622) (585 aa) fasta scores: E(): 3.1e-48, 43.626% id in 353 aa. Possible para-aminobenzoate synthetase pseudogene; para-aminobenzoate synthase component 801993 2861424 SAR0767 Staphylococcus aureus subsp. aureus MRSA252 para-aminobenzoate synthase component YP_040194.1 800842 D 282458 CDS YP_040195.1 49482971 2861425 801993..802601 1 NC_002952.2 Similar to C-terminal region of Streptococcus pyogenes para-aminobenzoate synthetase PabB TR:Q99XW6 (EMBL:AE006622) (585 aa) fasta scores: E(): 3.8e-06, 26.667% id in 180 aa, and to Haemophilus influenzae hypothetical protein HI1169 SW:YB69_HAEIN (P44118) (188 aa) fasta scores: E(): 0.0013, 26.154% id in 195 aa. Possible para-aminobenzoate synthetase pseudogene; para-aminobenzoate synthetase component 802601 2861425 SAR0768 Staphylococcus aureus subsp. aureus MRSA252 para-aminobenzoate synthetase component YP_040195.1 801993 D 282458 CDS YP_040196.1 49482972 2861426 802667..802873 1 NC_002952.2 Poor database matches. Similar to N-terminus of Lactococcus lactis hypothetical protein YdbD TR:Q9CIP2 (EMBL:AE006268) (118 aa) fasta scores: E(): 2.4, 32.432% id in 74 aa; hypothetical protein 802873 2861426 SAR0769 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040196.1 802667 D 282458 CDS YP_040197.1 49482973 2861427 802961..803671 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1817 TR:Q9KBV7 (EMBL:AP001513) (225 aa) fasta scores: E(): 1.1e-22, 32.420% id in 219 aa, and to Pyrococcus abyssi hypothetical protein PAB1713 TR:Q9V006 (EMBL:AJ248286) (225 aa) fasta scores: E(): 2.4e-15, 30.088% id in 226 aa; hypothetical protein 803671 2861427 SAR0770 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040197.1 802961 D 282458 CDS YP_040198.1 49482974 2861428 803655..804659 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1818 TR:Q9KBV6 (EMBL:AP001513) (331 aa) fasta scores: E(): 5.3e-32, 34.783% id in 322 aa, and to Pseudomonas aeruginosa hypothetical protein PA0496 TR:Q9I622 (EMBL:AE004486) (325 aa) fasta scores: E(): 8.2e-15, 29.394% id in 330 aa; hypothetical protein 804659 2861428 SAR0771 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040198.1 803655 D 282458 CDS YP_040199.1 49482975 2861429 805133..807073 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfnI TR:O06487 (EMBL:D86418) (653 aa) fasta scores: E(): 1.2e-132, 57.075% id in 636 aa, and to Lactococcus lactis hypothetical protein YibC TR:Q9CHC7 (EMBL:AE006314) (722 aa) fasta scores: E(): 3.3e-63, 37.705% id in 671 aa; sulfatase 807073 2861429 SAR0772 Staphylococcus aureus subsp. aureus MRSA252 sulfatase YP_040199.1 805133 D 282458 CDS YP_040200.1 49482976 2861430 807351..809228 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfmR TR:O06476 (EMBL:D86418) (629 aa) fasta scores: E(): 4.2e-80, 43.879% id in 629 aa, and to Streptococcus pyogenes ABC transporter spy0867 TR:Q9A0A4 (EMBL:AE006536) (625 aa) fasta scores: E(): 2.7e-76, 44.608% id in 612 aa; ABC transporter ATP-binding protein 809228 2861430 SAR0773 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040200.1 807351 D 282458 CDS YP_040201.1 49482977 2860958 809240..811021 1 NC_002952.2 Similar to Escherichia coli ATP-dependent DNA helicase RecQ SW:RECQ_ECOLI (P15043) (607 aa) fasta scores: E(): 8.3e-74, 37.186% id in 597 aa, and to Lactococcus lactis ATP-dependent DNA helicase RecQ TR:Q9CEM9 (EMBL:AE006411) (592 aa) fasta scores: E(): 8.5e-90, 44.370% id in 595 aa; ATP-dependent DNA helicase 811021 2860958 SAR0774 Staphylococcus aureus subsp. aureus MRSA252 ATP-dependent DNA helicase YP_040201.1 809240 D 282458 CDS YP_040202.1 49482978 2860959 811242..812219 1 NC_002952.2 Similar to Bacillus subtilis choline transport ATP-binding protein ProV SW:OPBA_BACSU (Q45460) (381 aa) fasta scores: E(): 1.7e-40, 45.687% id in 313 aa, and to Lactococcus lactis choline ABC transporter ATP binding protein ChoQ TR:Q9CH91 (EMBL:AE006318) (305 aa) fasta scores: E(): 5.9e-41, 43.671% id in 316 aa; ABC transporter ATP-binding protein 812219 2860959 SAR0775 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040202.1 811242 D 282458 CDS YP_040203.1 49482979 2860960 812212..813726 1 NC_002952.2 N-terminal region is similar to Bacillus subtilis choline ABC transporter permease ProW SW:OPBB_BACSU (Q45461) (217 aa) fasta scores: E(): 7.2e-30, 48.990% id in 198 aa. Full length CDS is similar to Streptococcus pyogenes ABC transporter SPY1134 TR:Q99ZQ2 (EMBL:AE006555) (510 aa) fasta scores: E(): 1.5e-91, 53.242% id in 509 aa; ABC transporter permease 813726 2860960 SAR0776 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_040203.1 812212 D 282458 CDS YP_040204.1 49482980 2860961 813966..815024 1 NC_002952.2 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 815024 2860961 SAR0777 Staphylococcus aureus subsp. aureus MRSA252 histidinol-phosphate aminotransferase YP_040204.1 813966 D 282458 CDS YP_040205.1 49482981 2860962 815183..815725 1 NC_002952.2 Similar to Homo sapiens mitochondrial 5'(3')-deoxyribonucleotidase DNT-2 TR:Q9NPB1 (EMBL:AJ277557) (228 aa) fasta scores: E(): 0.00049, 30.052% id in 193 aa, and to Similar to Bacillus subtilis hypothetical protein YorS TR:O31895 (EMBL:Z99114) (172 aa) fasta scores: E(): 5.6e-21, 39.306% id in 173 aa; hypothetical protein 815725 2860962 SAR0778 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040205.1 815183 D 282458 CDS YP_040206.1 49482982 2860963 815730..815864 1 NC_002952.2 Poor database matches. Similar to C-terminal region of Streptococcus thermophilus hypothetical protein EpsB TR:O87929 (EMBL:AF053347) (243 aa) fasta scores: E(): 9.2, 35.135% id in 37 aa; hypothetical protein 815864 2860963 SAR0779 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040206.1 815730 D 282458 CDS YP_040207.1 49482983 2860964 complement(816277..817194) 1 NC_002952.2 Similar to Bacillus subtilis multidrug transporter regulatory protein BmrU SW:BMRU_BACSU (P39074) (297 aa) fasta scores: E(): 3.5e-28, 31.757% id in 296 aa, and to Bacillus halodurans multidrug resistance protein BmrU TR:Q9KC00 (EMBL:AP001513) (311 aa) fasta scores: E(): 3.6e-21, 27.891% id in 294 aa; diacylglycerol kinase 817194 2860964 SAR0780 Staphylococcus aureus subsp. aureus MRSA252 diacylglycerol kinase YP_040207.1 816277 R 282458 CDS YP_040208.1 49482984 2860965 complement(817464..818969) 1 NC_002952.2 Similar to Lactococcus lactis di-/tripeptide transporter DtpT SW:DTPT_LACLA (P36574) (463 aa) fasta scores: E(): 1.3e-68, 39.355% id in 465 aa, and to Bacillus subtilis hypothetical protein YclF SW:YCLF_BACSU (P94408) (492 aa) fasta scores: E(): 8.9e-90, 48.780% id in 492 aa. CDS is extended at the N-terminus in comparison to the Lactococcus lactis protein. Possible alternative translational start site; proton-dependent oligopeptide transport protein 818969 2860965 SAR0781 Staphylococcus aureus subsp. aureus MRSA252 proton-dependent oligopeptide transport protein YP_040208.1 817464 R 282458 CDS YP_040209.1 49482985 2860966 complement(819309..819809) 1 NC_002952.2 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 819809 2860966 SAR0782 Staphylococcus aureus subsp. aureus MRSA252 7-cyano-7-deazaguanine reductase YP_040209.1 819309 R 282458 CDS YP_040210.1 49482986 2860967 complement(819829..820695) 1 NC_002952.2 Similar to Treponema pallidum conserved hypothetical integral membrane protein TP0986 TR:O83951 (EMBL:AE001266) (294 aa) fasta scores: E(): 1.5e-32, 37.979% id in 287 aa, and to Pseudomonas aeruginosa hypothetical protein PA4834 TR:Q9HUX6 (EMBL:AE004896) (284 aa) fasta scores: E(): 1e-20, 31.481% id in 270 aa; hypothetical protein 820695 2860967 SAR0783 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040210.1 819829 R 282458 CDS YP_040211.1 49482987 2860968 821497..821895 1 NC_002952.2 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 821895 nrdI 2860968 nrdI Staphylococcus aureus subsp. aureus MRSA252 ribonucleotide reductase stimulatory protein YP_040211.1 821497 D 282458 CDS YP_040212.1 49482988 2859272 821858..823963 1 NC_002952.2 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 823963 rir1 2859272 rir1 Staphylococcus aureus subsp. aureus MRSA252 ribonucleotide-diphosphate reductase subunit alpha YP_040212.1 821858 D 282458 CDS YP_040213.1 49482989 2859273 824083..825054 1 NC_002952.2 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 825054 nrdF 2859273 nrdF Staphylococcus aureus subsp. aureus MRSA252 ribonucleotide-diphosphate reductase subunit beta YP_040213.1 824083 D 282458 CDS YP_040214.1 49482990 2859509 825431..826402 1 NC_002952.2 Similar to Vibrio anguillarum ferric anguibactin ABC transporter permease FatD SW:FATD_VIBAN (P37738) (314 aa) fasta scores: E(): 4.6e-40, 35.599% id in 309 aa. Previously sequenced as Staphylococcus aureus iron transport membrane protein SstA TR:O87825 (EMBL:AJ005352) (323 aa) fasta scores: E(): 1.6e-104, 97.214% id in 323 aa; FecCD transport family protein 826402 sstA 2859509 sstA Staphylococcus aureus subsp. aureus MRSA252 FecCD transport family protein YP_040214.1 825431 D 282458 CDS YP_040215.1 49482991 2859510 826389..827345 1 NC_002952.2 Similar to Vibrio anguillarum ferric anguibactin ABC transporter permease FatC SW:FATC_VIBAN (P37737) (317 aa) fasta scores: E(): 9.6e-26, 28.797% id in 316 aa, and to Staphylococcus aureus iron transport membrane protein SstB TR:O87826 (EMBL:AJ005352) (226 aa) fasta scores: E(): 1.1e-70, 99.107% id in 224 aa; FecCD transport family protein 827345 sstB 2859510 sstB Staphylococcus aureus subsp. aureus MRSA252 FecCD transport family protein YP_040215.1 826389 D 282458 CDS YP_040216.1 49482992 2859511 827342..828103 1 NC_002952.2 Similar to Escherichia coli citrate-dependent iron(III) transport system, ATP-binding protein FecE SW:FECE_ECOLI (P15031) (255 aa) fasta scores: E(): 2.5e-24, 37.903% id in 248 aa, and to Staphylococcus aureus iron transport ATP-binding protein SstC TR:O87827 (EMBL:AJ005352) (253 aa) fasta scores: E(): 1.9e-78, 96.047% id in 253 aa; ABC transporter ATP-binding protein 828103 sstC 2859511 sstC Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040216.1 827342 D 282458 CDS YP_040217.1 49482993 2859512 828218..829246 1 NC_002952.2 Similar to Vibrio anguillarum ferric anguibactin-binding protein precursor FatB SW:FATB_VIBAN (P11460) (322 aa) fasta scores: E(): 9.7e-18, 30.45% id in 266 aa, and to Staphylococcus aureus iron transporter lipoprotein SstD TR:O87828 (EMBL:AJ005352) (342 aa) fasta scores: E(): 2.2e-110, 97.07% id in 342 aa; lipoprotein 829246 sstD 2859512 sstD Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_040217.1 828218 D 282458 CDS YP_040218.1 49482994 2860969 complement(829563..829877) 1 NC_002952.2 Similar to Saccharomyces cerevisiae hypothetical protein YKl084W SW:YKI4_YEAST (P36078) (116 aa) fasta scores: E(): 1.2e-19, 45.192% id in 104 aa, and to Schizosaccharomyces pombe hypothetical protein SPAC29B12.12 TR:O14033 (EMBL:Z99164) (113 aa) fasta scores: E(): 6.7e-17, 41.000% id in 100 aa; hypothetical protein 829877 2860969 SAR0791 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040218.1 829563 R 282458 CDS YP_040219.1 49482995 2861320 complement(829895..830818) 1 NC_002952.2 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 830818 murB 2861320 murB Staphylococcus aureus subsp. aureus MRSA252 UDP-N-acetylenolpyruvoylglucosamine reductase YP_040219.1 829895 R 282458 CDS YP_040220.1 49482996 2860970 complement(830945..831463) 1 NC_002952.2 Poor database matches. C-terminus is similar to the C-terminal region of Bacillus firmus glutamate-rich protein GrpB SW:GRPB_BACFI (Q45133) (174 aa) fasta scores: E(): 2.3e-06, 25.517% id in 145 aa; hypothetical protein 831463 2860970 SAR0793 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040220.1 830945 R 282458 CDS YP_040221.1 49482997 2860971 831583..832461 1 NC_002952.2 N-terminal region is similar to Borrelia burgdorferi lipoprotein Bbk2.11 TR:Q44739 (EMBL:U30617) (233 aa) fasta scores: E(): 0.15, 21.702% id in 235 aa. Full length CDS is similar to N-terminal region of Ureaplasma parvum hypothetical lipoprotein UU125 TR:Q9PR19 (EMBL:AE002113) (394 aa) fasta scores: E(): 0.18, 25.085% id in 295 aa; hypothetical protein 832461 2860971 SAR0794 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040221.1 831583 D 282458 CDS YP_040222.1 49482998 2860972 832615..832935 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtxJ SW:YTXJ_BACSU (P39914) (108 aa) fasta scores: E(): 4.3e-12, 43.564% id in 101 aa, and to Bacillus halodurans general stress protein BH3013 TR:Q9K8J3 (EMBL:AP001517) (112 aa) fasta scores: E(): 1.2e-09, 36.792% id in 106 aa; hypothetical protein 832935 2860972 SAR0795 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040222.1 832615 D 282458 CDS YP_040223.1 49482999 2860973 833360..834484 1 NC_002952.2 Similar to Escherichia coli glycerate kinase 1 GlxK SW:GRK1_ECOLI (P77364) (381 aa) fasta scores: E(): 7.1e-18, 23.699% id in 346 aa, and to Bacillus halodurans glycerate kinase GlxK SW:GRK_BACHD (Q9Z9P2) (380 aa) fasta scores: E(): 2.9e-21, 25.656% id in 343 aa; glycerate kinase 834484 2860973 SAR0796 Staphylococcus aureus subsp. aureus MRSA252 glycerate kinase YP_040223.1 833360 D 282458 CDS YP_040224.1 49483000 2859895 complement(834672..835898) 1 NC_002952.2 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 835898 pepT 2859895 pepT Staphylococcus aureus subsp. aureus MRSA252 peptidase T YP_040224.1 834672 R 282458 CDS YP_040225.1 49483001 2860974 complement(835912..836406) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0082 TR:Q9KGH9 (EMBL:AP001507) (150 aa) fasta scores: E(): 7.4e-12, 37.500% id in 136 aa, and to Pasteurella multocida hypothetical protein PM1894 TR:Q9CJU7 (EMBL:AE006227) (153 aa) fasta scores: E(): 5.8e-07, 29.655% id in 145 aa; hypothetical protein 836406 2860974 SAR0798 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040225.1 835912 R 282458 CDS YP_040226.1 49483002 2860975 complement(836424..837185) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0081 TR:Q9KGI0 (EMBL:AP001507) (251 aa) fasta scores: E(): 1.9e-30, 36.800% id in 250 aa, and to Campylobacter jejuni integral membrane protein CJ1166C TR:Q9PNC9 (EMBL:AL139077) (258 aa) fasta scores: E(): 1.5e-08, 22.619% id in 252 aa; hypothetical protein 837185 2860975 SAR0799 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040226.1 836424 R 282458 CDS YP_040227.1 49483003 2860976 complement(837381..838451) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhcK SW:YHCK_BACSU (P54595) (359 aa) fasta scores: E(): 1.8e-19, 27.901% id in 362 aa, and to Deinococcus radiodurans GGDEF family protein DR1090 TR:Q9RVD9 (EMBL:AE001959) (356 aa) fasta scores: E(): 1.7e-13, 26.158% id in 367 aa; hypothetical protein 838451 2860976 SAR0800 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040227.1 837381 R 282458 CDS YP_040228.1 49483004 2860977 838769..839824 1 NC_002952.2 Previously sequenced as Staphylococcus aureus lipophilic protein that affects bacterial lysis and methicillin resistance levels Llm TR:Q53761 (EMBL:D21131) (351 aa) fasta scores: E(): 4.5e-118, 99.715% id in 351 aa. Similar to Escherichia coli UDP-phosphate alpha-N-acetylglucosaminyltransferase Rfe SW:RFE_ECOLI (P24235) (367 aa) fasta scores: E(): 5e-19, 26.647% id in 334 aa; glycosyl transferase 839824 2860977 SAR0801 Staphylococcus aureus subsp. aureus MRSA252 glycosyl transferase YP_040228.1 838769 D 282458 CDS YP_040229.1 49483005 2859188 complement(839988..840629) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3630 TR:Q9K6U5 (EMBL:AP001519) (213 aa) fasta scores: E(): 2.7e-32, 45.972% id in 211 aa, and to Bacillus subtilis hypothetical protein YvhK SW:YVYE_BACSU (P32437) (217 aa) fasta scores: E(): 2.2e-31, 48.000% id in 200 aa; hypothetical protein 840629 2859188 SAR0802 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040229.1 839988 R 282458 CDS YP_040230.1 49483006 2859372 840773..841639 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3627 TR:Q9K6U8 (EMBL:AP001519) (283 aa) fasta scores: E(): 3e-35, 38.869% id in 283 aa, and to Bacillus subtilis hypothetical protein DegV SW:DEGV_BACSU (P32436) (281 aa) fasta scores: E(): 4.9e-33, 37.276% id in 279 aa; hypothetical protein 841639 2859372 SAR0803 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040230.1 840773 D 282458 CDS YP_040231.1 49483007 2860718 842003..843085 1 NC_002952.2 Similar to the C-terminal regions of Bacillus halodurans late competence protein ComFA TR:Q9K6U9 (EMBL:AP001519) (441 aa) fasta scores: E(): 5.6e-33, 34.835% id in 333 aa, and to Bacillus subtilis comF operon protein 1 ComFA SW:CMF1_BACSU (P39145) (463 aa) fasta scores: E(): 2.4e-31, 37.808% id in 365 aa. Similarity to the N-terminal region of the Bacillus subtilis comF operon protein 1 upstream of the predicted translational start. No alternative upstream translational start site. Possible truncated protein; helicase 843085 2860718 SAR0804 Staphylococcus aureus subsp. aureus MRSA252 helicase YP_040231.1 842003 D 282458 CDS YP_040232.1 49483008 2860719 843078..843752 1 NC_002952.2 Similar to Bacillus subtilis comF operon protein 3 ComFC SW:CMF3_BACSU (P39147) (229 aa) fasta scores: E(): 4e-09, 27.966% id in 236 aa, and to Lactococcus lactis competence protein ComFC TR:Q9CGK7 (EMBL:AE006341) (216 aa) fasta scores: E(): 7.3e-14, 33.624% id in 229 aa; hypothetical protein 843752 2860719 SAR0805 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040232.1 843078 D 282458 CDS YP_040233.1 49483009 2860720 843813..844385 1 NC_002952.2 Similar to Spinacia oleracea plastid-specific 30S ribosomal protein 1 S22 SW:RR30_SPIOL (P19954) (302 aa) fasta scores: E(): 2.2e-05, 29.064% id in 203 aa, and to Lactococcus lactis hypothetical protein TR:Q9L474 (EMBL:AJ249134) (185 aa) fasta scores: E(): 2.6e-34, 53.191% id in 188 aa; S30EA family ribosomal protein 844385 2860720 SAR0806 Staphylococcus aureus subsp. aureus MRSA252 S30EA family ribosomal protein YP_040233.1 843813 D 282458 CDS YP_040234.1 49483010 2859133 844799..847330 1 NC_002952.2 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 847330 secA 2859133 secA Staphylococcus aureus subsp. aureus MRSA252 preprotein translocase subunit SecA YP_040234.1 844799 D 282458 CDS YP_040235.1 49483011 2860149 join(847645..847716,847718..848755) 1 NC_002952.2 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 848755 prfB 2860149 prfB Staphylococcus aureus subsp. aureus MRSA252 peptide chain release factor 2 YP_040235.1 847645 D 282458 CDS YP_040236.1 49483012 2860721 849524..850363 1 NC_002952.2 Poor database matches. C-terminal region is similar to C-terminus of Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 6.6e-16, 49.624% id in 133 aa. Full length CDS is similar to the C-terminus of Streptococcus agalactiae cell wall separation protein PcsB TR:Q9AKA4 (EMBL:AJ277292) (447 aa) fasta scores: E(): 4.8e-09, 30.515% id in 272 aa; hypothetical protein 850363 2860721 SAR0809 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040236.1 849524 D 282458 CDS YP_040237.1 49483013 2860722 850537..851187 1 NC_002952.2 Similar to Escherichia coli hypothetical protein B2291 TR:P76491 (EMBL:AE000318) (199 aa) fasta scores: E(): 1.2e-06, 24.468% id in 188 aa, and to Vibrio cholerae hypothetical protein VC1978 TR:Q9KQM0 (EMBL:AE004273) (233 aa) fasta scores: E(): 2.7e-06, 25.532% id in 188 aa; phosphohydrolase 851187 2860722 SAR0810 Staphylococcus aureus subsp. aureus MRSA252 phosphohydrolase YP_040237.1 850537 D 282458 CDS YP_040238.1 49483014 2860723 851184..851420 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis membrane protein CsbA SW:CSBA_BACSU (P37953) (76 aa) fasta scores: E(): 0.00017, 40.580% id in 69 aa; hypothetical protein 851420 2860723 SAR0811 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040238.1 851184 D 282458 CDS YP_040239.1 49483015 2860424 851683..853674 1 NC_002952.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 853674 uvrB 2860424 uvrB Staphylococcus aureus subsp. aureus MRSA252 excinuclease ABC subunit B YP_040239.1 851683 D 282458 CDS YP_040240.1 49483016 2860423 853682..856528 1 NC_002952.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 856528 uvrA 2860423 uvrA Staphylococcus aureus subsp. aureus MRSA252 excinuclease ABC subunit A YP_040240.1 853682 D 282458 CDS YP_040241.1 49483017 2859645 857139..858071 1 NC_002952.2 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 858071 hprK 2859645 hprK Staphylococcus aureus subsp. aureus MRSA252 HPr kinase/phosphorylase YP_040241.1 857139 D 282458 CDS YP_040242.1 49483018 2859802 858077..858919 1 NC_002952.2 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 858919 lgt 2859802 lgt Staphylococcus aureus subsp. aureus MRSA252 prolipoprotein diacylglyceryl transferase YP_040242.1 858077 D 282458 CDS YP_040243.1 49483019 2860724 858927..859412 1 NC_002952.2 Similar to Escherichia coli maltose O-acetyltransferase Maa SW:MAA_ECOLI (P77791) (182 aa) fasta scores: E(): 6e-09, 35.185% id in 162 aa, and to Staphylococcus xylosus acetyltransferase YvoF TR:Q9S1H3 (EMBL:AJ243915) (158 aa) fasta scores: E(): 3.8e-34, 59.236% id in 157 aa; acetyltransferase 859412 2860724 SAR0816 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_040243.1 858927 D 282458 CDS YP_040244.1 49483020 2860725 859420..860859 1 NC_002952.2 Similar to Staphylococcus xylosus hypothetical protein YvcD TR:Q9S1H2 (EMBL:AJ243915) (478 aa) fasta scores: E(): 6.8e-124, 62.213% id in 479 aa, and to Bacillus subtilis hypothetical protein YvcD TR:O06968 (EMBL:Z94043) (484 aa) fasta scores: E(): 1.7e-13, 21.224% id in 490 aa; hypothetical protein 860859 2860725 SAR0817 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040244.1 859420 D 282458 CDS YP_040245.1 49483021 2860406 860926..861861 1 NC_002952.2 Similar to Streptomyces clavuligerus thioredoxin reductase TrxB SW:TRXB_STRCL (Q05741) (321 aa) fasta scores: E(): 1.7e-44, 45.928% id in 307 aa, and to Bacillus subtilis thioredoxin reductase TrxB SW:TRXB_BACSU (P80880) (315 aa) fasta scores: E(): 9.7e-81, 72.368% id in 304 aa; thioredoxin reductase 861861 trxB 2860406 trxB Staphylococcus aureus subsp. aureus MRSA252 thioredoxin reductase YP_040245.1 860926 D 282458 CDS YP_040246.1 49483022 2860726 862629..863540 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YvcJ SW:YVCJ_BACSU (O06973) (295 aa) fasta scores: E(): 2.5e-58, 52.862% id in 297 aa, and to Bacillus halodurans hypothetical protein BH3569 TR:Q9K705 (EMBL:AP001519) (295 aa) fasta scores: E(): 8.9e-56, 51.678% id in 298 aa; hypothetical protein 863540 2860726 SAR0820 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040246.1 862629 D 282458 CDS YP_040247.1 49483023 2860727 863537..864532 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3568 TR:Q9K706 (EMBL:AP001519) (322 aa) fasta scores: E(): 9.1e-56, 50.955% id in 314 aa, and to Bacillus subtilis hypothetical protein YvcK SW:YVCK_BACSU (O06974) (317 aa) fasta scores: E(): 5.3e-55, 47.771% id in 314 aa; hypothetical protein 864532 2860727 SAR0821 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040247.1 863537 D 282458 CDS YP_040248.1 49483024 2860728 864641..865585 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YvcL TR:O06975 (EMBL:Z94043) (316 aa) fasta scores: E(): 1.2e-68, 62.222% id in 315 aa, and to Bacillus halodurans hypothetical protein BH3567 protein bh3567 TR:Q9K707 (EMBL:AP001519) (320 aa) fasta scores: E(): 3.5e-67, 62.540% id in 315 aa; hypothetical protein 865585 2860728 SAR0822 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040248.1 864641 D 282458 CDS YP_040249.1 49483025 2859236 866154..866741 1 NC_002952.2 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 866741 clpP 2859236 clpP Staphylococcus aureus subsp. aureus MRSA252 ATP-dependent Clp protease proteolytic subunit YP_040249.1 866154 D 282458 CDS YP_040250.1 49483026 2860729 866923..868557 1 NC_002952.2 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 868557 2860729 SAR0824 Staphylococcus aureus subsp. aureus MRSA252 malate dehydrogenase YP_040250.1 866923 D 282458 CDS YP_040251.1 49483027 2860730 complement(868764..869666) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfhF SW:YFHF_BACSU (O31574) (303 aa) fasta scores: E(): 1.4e-43, 40.878% id in 296 aa, and to Pseudomonas aeruginosa hypothetical protein PA4656 TR:Q9HVD6 (EMBL:AE004879) (305 aa) fasta scores: E(): 1e-35, 36.700% id in 297 aa; hypothetical protein 869666 2860730 SAR0825 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040251.1 868764 R 282458 CDS YP_040252.1 49483028 2860731 870369..870998 1 NC_002952.2 No significant database matches. CDS is Lys and Gln rich (17.7% and 15.3% of total amino acid content, respectively). Contains coiled-coiled domain, residues 58 to 87; hypothetical protein 870998 2860731 SAR0826 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040252.1 870369 D 282458 CDS YP_040253.1 49483029 2860690 871492..872505 1 NC_002952.2 Previously sequenced as Staphylococcus aureus glycolytic operon regulator GapR TR:Q9Z5C6 (EMBL:AJ133520) (337 aa) fasta scores: E(): 2.8e-118, 99.407% id in 337 aa. Similar to Bacillus megaterium central glycolytic genes regulator CggR SW:CGGR_BACME (P35168) (342 aa) fasta scores: E(): 6.4e-52, 47.024% id in 336 aa; glycolytic operon regulator 872505 gapR 2860690 gapR Staphylococcus aureus subsp. aureus MRSA252 glycolytic operon regulator YP_040253.1 871492 D 282458 CDS YP_040254.1 49483030 2860688 872558..873568 1 NC_002952.2 Similar to Streptococcus pyogenes glyceraldehyde 3-phosphate dehydrogenase, and human plasmin receptor, Plr SW:G3P_STRPY (P50467) (335 aa) fasta scores: E(): 4.4e-83, 68.060% id in 335 aa. Previously sequenced as Staphylococcus aureus glyceraldehyde-3-phosphate dehydrogenase Gap TR:Q9Z5C5 (EMBL:AJ133520) (336 aa) fasta scores: E(): 2.7e-122, 100.000% id in 336 aa; glyceraldehyde 3-phosphate dehydrogenase 1 873568 gap1 2860688 gap1 Staphylococcus aureus subsp. aureus MRSA252 glyceraldehyde 3-phosphate dehydrogenase 1 YP_040254.1 872558 D 282458 CDS YP_040255.1 49483031 2859899 873707..874897 1 NC_002952.2 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 874897 pgk 2859899 pgk Staphylococcus aureus subsp. aureus MRSA252 phosphoglycerate kinase YP_040255.1 873707 D 282458 CDS YP_040256.1 49483032 2860394 875019..875780 1 NC_002952.2 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 875780 tpiA 2860394 tpiA Staphylococcus aureus subsp. aureus MRSA252 triosephosphate isomerase YP_040256.1 875019 D 282458 CDS YP_040257.1 49483033 2859900 875783..877300 1 NC_002952.2 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 877300 pgm 2859900 pgm Staphylococcus aureus subsp. aureus MRSA252 phosphoglyceromutase YP_040257.1 875783 D 282458 CDS YP_040258.1 49483034 2859612 877430..878734 1 NC_002952.2 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 878734 eno 2859612 eno Staphylococcus aureus subsp. aureus MRSA252 phosphopyruvate hydratase YP_040258.1 877430 D 282458 CDS YP_040259.1 49483035 2860862 879071..879529 1 NC_002952.2 Poor database matches. Similar to an internal region of Helicobacter pylori J99 hypothetical protein JHP0324 TR:Q9ZM98 (EMBL:AE001468) (220 aa) fasta scores: E(): 0.72, 25.874% id in 143 aa; hypothetical protein 879529 2860862 SAR0833 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040259.1 879071 D 282458 CDS YP_040260.1 49483036 2859136 879596..879829 1 NC_002952.2 Similar to Escherichia coli protein-export membrane protein SecG SW:SECG_ECOLI (P33582) (110 aa) fasta scores: E(): 0.0082, 31.507% id in 73 aa, and to Bacillus subtilis probable protein-export membrane protein SecG SW:SECG_BACSU (O32233) (76 aa) fasta scores: E(): 1.1e-15, 66.667% id in 75 aa; preprotein translocase subunit SecG 879829 secG 2859136 secG Staphylococcus aureus subsp. aureus MRSA252 preprotein translocase subunit SecG YP_040260.1 879596 D 282458 CDS YP_040261.1 49483037 2859616 879958..880698 1 NC_002952.2 Similar to Bacillus stearothermophilus carboxylesterase precursor Est SW:EST_BACST (Q06174) (247 aa) fasta scores: E(): 3.1e-53, 58.130% id in 246 aa, and to Bacillus halodurans carboxylesterase BH3554 TR:Q9K719 (EMBL:AP001519) (248 aa) fasta scores: E(): 6.8e-51, 56.048% id in 248 aa; carboxylesterase 880698 est 2859616 est Staphylococcus aureus subsp. aureus MRSA252 carboxylesterase YP_040261.1 879958 D 282458 CDS YP_040262.1 49483038 2859279 880732..883104 1 NC_002952.2 Similar to Escherichia coli ribonuclease R Rnr SW:RNR_ECOLI (P21499) (813 aa) fasta scores: E(): 1.9e-79, 34.875% id in 800 aa, and to Bacillus subtilis ribonuclease R Rnr SW:RNR_BACSU (O32231) (779 aa) fasta scores: E(): 9.8e-148, 53.169% id in 773 aa. Rnr is required for expression of virulence in Shigella and enteroinvasive Escherichia coli; ribonuclease R 883104 rnr 2859279 rnr Staphylococcus aureus subsp. aureus MRSA252 ribonuclease R YP_040262.1 880732 D 282458 CDS YP_040263.1 49483039 2859149 883126..883590 1 NC_002952.2 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 883590 smpB 2859149 smpB Staphylococcus aureus subsp. aureus MRSA252 SsrA-binding protein YP_040263.1 883126 D 282458 CDS YP_040264.1 49483040 2860863 884556..885170 1 NC_002952.2 Poor database matches. Similar to Lactococcus lactis plasmid pCD4 hypothetical protein Orf1 TR:Q9AC96 (EMBL:AF306799) (193 aa) fasta scores: E(): 3.3e-09, 27.895% id in 190 aa, and to Methanococcus jannaschii hypothetical protein MJ0793 SW:Y793_METJA (Q58203) (178 aa) fasta scores: E(): 0.014, 26.203% id in 187 aa; hypothetical protein 885170 2860863 SAR0838 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040264.1 884556 D 282458 CDS YP_040265.1 49483041 2860864 complement(885458..886186) 1 NC_002952.2 Poor database matches. N-terminus is similar to N-terminal region of Bacillus subtilis lipoprotein YjhA TR:O34725 (EMBL:AF015825) (213 aa) fasta scores: E(): 0.55, 32.639% id in 144 aa. CDS contains a C-terminal hydrophilic domain; hypothetical protein 886186 2860864 SAR0839 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040265.1 885458 R 282458 CDS YP_040266.1 49483042 2860865 886785..887306 1 NC_002952.2 No significant database matches to the full length CDS. N-terminus is similar to N-terminal region of Helicobacter pylori J99 hypothetical protein JHP0535 TR:Q9ZLP3 (EMBL:AE001486) (329 aa) fasta scores: E(): 6.2, 25.926% id in 135 aa; hypothetical protein 887306 2860865 SAR0840 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040266.1 886785 D 282458 CDS YP_040267.1 49483043 2860866 887445..887975 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YafC TR:Q9CJE1 (EMBL:AE006244) (173 aa) fasta scores: E(): 7.7e-27, 47.399% id in 173 aa, and to Pseudomonas aeruginosa hypothetical protein PA0711 TR:Q9I5L7 (EMBL:AE004506) (168 aa) fasta scores: E(): 1e-07, 31.250% id in 176 aa; acetyltransferase 887975 2860866 SAR0841 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_040267.1 887445 D 282458 CDS YP_040268.1 49483044 2859231 888239..891328 1 NC_002952.2 Previously sequenced as Staphylococcus aureus clumping factor ClfA TR:Q53653 (EMBL:Z18852) (933 aa) fasta scores: E(): 2.3e-215, 86.297% id in 1029 aa. Similar to the C-terminal region of Staphylococcus epidermidis cell-surface adhesin SdrF TR:Q9KI14 (EMBL:AF245041) (1733 aa) fasta scores: E(): 1.5e-94, 46.230% id in 1008 aa. Contains an inperfect dipetide repeat (SD x181), residues 599 to 960. CDS contains extra copies of the dipeptide repeat compared to the previously sequenced clumping factor ClfA. Probable LPXTG-sorted surface protein; clumping factor 891328 clfA 2859231 clfA Staphylococcus aureus subsp. aureus MRSA252 clumping factor YP_040268.1 888239 D 282458 CDS YP_040269.1 49483045 2860868 893407..894432 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus extracellular matrix and plasma binding protein precursor Ssp TR:Q9L3L5 (EMBL:AJ272084) (340 aa) fasta scores: E(): 1.6e-106, 86.550% id in 342 aa; hypothetical protein 894432 2860868 SAR0845 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040269.1 893407 D 282458 CDS YP_040270.1 49483046 2860869 894763..895320 1 NC_002952.2 Poor database matches. Similar to C-terminal region of Staphylococcus aureus secreted von Willebrand factor-binding protein precursor Vwb TR:AAK52333 (EMBL:AY032850) (508 aa) fasta scores: E(): 6e-15, 38.889% id in 162 aa. N-terminus is similar to the N-terminal region of Staphylococcus aureus extracellular matrix and plasma binding protein precursor Ssp TR:Q9K2Q1 (EMBL:AJ272083) (340 aa) fasta scores: E(): 1.2, 36.000% id in 100 aa; hypothetical protein 895320 2860869 SAR0846 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040270.1 894763 D 282458 CDS YP_040271.1 49483047 2859168 895661..896347 1 NC_002952.2 Similar to Staphylococcus aureus thermonuclease precursor Nuc SW:NUC_STAAU (P00644) (231 aa) fasta scores: E(): 4.9e-80, 98.246% id in 228 aa. C-terminal region is similar to Bacillus subtilis hypothetical protein YncB TR:P94492 (EMBL:U66480) (211 aa) fasta scores: E(): 1e-22, 45.745% id in 188 aa; thermonuclease precursor 896347 nuc 2859168 nuc Staphylococcus aureus subsp. aureus MRSA252 thermonuclease precursor YP_040271.1 895661 D 282458 CDS YP_040272.1 49483048 2859249 896704..896904 1 NC_002952.2 Similar to Bacillus cereus cold shock-like protein CspC SW:CSPC_BACCE (Q45098) (65 aa) fasta scores: E(): 3.2e-20, 85.714% id in 63 aa, and to Bacillus subtilis cold shock protein CspC SW:CSPC_BACSU (P39158) (66 aa) fasta scores: E(): 2.8e-18, 76.923% id in 65 aa. Similar to SAR1414, 80.303% identity (80.303% ungapped) in 66 aa overlap, and to SAR2790, 80.952% identity (80.952% ungapped) in 63 aa overlap; cold shock protein 896904 cspC 2859249 cspC Staphylococcus aureus subsp. aureus MRSA252 cold shock protein YP_040272.1 896704 D 282458 CDS YP_040273.1 49483049 2860870 complement(897401..897619) 1 NC_002952.2 hypothetical protein 897619 2860870 SAR0849 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040273.1 897401 R 282458 CDS YP_040274.1 49483050 2860871 complement(897681..897965) 1 NC_002952.2 Poor database matches. Similar to N-terminal region of Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf121 TR:Q9B0H0 (EMBL:AB045978) (121 aa) fasta scores: E(): 3.6e-06, 32.258% id in 93 aa; hypothetical protein 897965 2860871 SAR0850 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040274.1 897681 R 282458 CDS YP_040275.1 49483051 2860872 complement(898053..898622) 1 NC_002952.2 Poor database matches. N-terminus is similar to N-terminal region of Bacillus thuringiensis hypothetical protein SW:YGI2_BACTU (P10023) (270 aa) fasta scores: E(): 9.1e-11, 33.125% id in 160 aa; hypothetical protein 898622 2860872 SAR0851 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040275.1 898053 R 282458 CDS YP_040276.1 49483052 2860873 complement(898810..898998) 1 NC_002952.2 Poor database matches. Similar to an internal region of Corynebacterium glutamicum lincomycin resistance protein LmrB TR:Q9L6D2 (EMBL:AF237667) (481 aa) fasta scores: E(): 1.7, 38.095% id in 63 aa. Doubtful CDS; hypothetical protein 898998 2860873 SAR0852 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040276.1 898810 R 282458 CDS YP_040277.1 49483053 2860874 complement(899027..899287) 1 NC_002952.2 Poor database matches. Weakly similar to Sulfolobus solfataricus hypothetical protein SSO0816 TR:Q9UXK1 (EMBL:Y18930) (110 aa) fasta scores: E(): 2, 24.138% id in 87 aa; hypothetical protein 899287 2860874 SAR0853 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040277.1 899027 R 282458 CDS YP_040278.1 49483054 2860875 899628..899831 1 NC_002952.2 Poor database matches. N-terminus is similar to N-terminal region of Streptococcus pyogenes hypothetical protein SPY0467 TR:Q9A148 (EMBL:AE006506) (71 aa) fasta scores: E(): 3.7, 33.333% id in 45 aa; hypothetical protein 899831 2860875 SAR0854 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040278.1 899628 D 282458 CDS YP_040279.1 49483055 2860876 complement(899828..900064) 1 NC_002952.2 hypothetical protein 900064 2860876 SAR0855 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040279.1 899828 R 282458 CDS YP_040280.1 49483056 2860877 900289..900870 1 NC_002952.2 Similar to an internal region of Salmonella typhimurium alpha-ribazole-5'-phosphate phosphatase CobC SW:COBC_SALTY (P39701) (234 aa) fasta scores: E(): 0.00019, 28.402% id in 169 aa, and to Thermotoga maritima phosphoglycerate mutase TM1374 TR:Q9X194 (EMBL:AE001791) (201 aa) fasta scores: E(): 3e-07, 29.949% id in 197 aa; phosphoglycerate mutase 900870 2860877 SAR0856 Staphylococcus aureus subsp. aureus MRSA252 phosphoglycerate mutase YP_040280.1 900289 D 282458 CDS YP_040281.1 49483057 2860878 complement(900943..901560) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0431 TR:Q9KFP7 (EMBL:AP001508) (200 aa) fasta scores: E(): 1.7e-29, 43.939% id in 198 aa, and to Escherichia coli hypothetical protein YggA SW:YGGA_ECOLI (P11667) (211 aa) fasta scores: E(): 2.3e-13, 32.394% id in 213 aa. Similar to SAR2591, 63.415% identity (63.415% ungapped) in 205 aa overlap; LysE type translocator protein 901560 2860878 SAR0857 Staphylococcus aureus subsp. aureus MRSA252 LysE type translocator protein YP_040281.1 900943 R 282458 CDS YP_040282.1 49483058 2860879 complement(901716..902210) 1 NC_002952.2 Poor database matches. Similar to bacteriophage bIL311 hypothetical protein Orf17 TR:Q9AZG4 (EMBL:AF323672) (168 aa) fasta scores: E(): 9.2e-06, 26.380% id in 163 aa; hypothetical protein 902210 2860879 SAR0858 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040282.1 901716 R 282458 CDS YP_040284.1 49483060 2860880 complement(902609..903031) 1 NC_002952.2 Similar to Xanthomonas campestris organic hydroperoxide resistance protein Ohr SW:OHR_XANCH (O68390) (142 aa) fasta scores: E(): 1e-11, 35.507% id in 138 aa, and to Bacillus subtilis general stress protein YkzA SW:G17O_BACSU (P80242) (135 aa) fasta scores: E(): 2.3e-17, 43.284% id in 134 aa; OsmC-like protein 903031 2860880 SAR0859 Staphylococcus aureus subsp. aureus MRSA252 OsmC-like protein YP_040284.1 902609 R 282458 CDS YP_040285.1 49483061 2860881 903179..903895 1 NC_002952.2 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 903895 2860881 SAR0860 Staphylococcus aureus subsp. aureus MRSA252 3-dehydroquinate dehydratase YP_040285.1 903179 D 282458 CDS YP_040286.1 49483062 2860882 903978..904517 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0303 TR:Q9KG12 (EMBL:AP001508) (184 aa) fasta scores: E(): 2.6e-18, 34.637% id in 179 aa, and to Bacillus subtilis hypothetical protein YfhC TR:O31571 (EMBL:Z99108) (194 aa) fasta scores: E(): 2.7e-14, 31.034% id in 174 aa; nitroreductase 904517 2860882 SAR0861 Staphylococcus aureus subsp. aureus MRSA252 nitroreductase YP_040286.1 903978 D 282458 CDS YP_040287.1 49483063 2860883 complement(904667..904987) 1 NC_002952.2 Similar to Saccharomyces cerevisiae thioredoxin II TRX2 SW:TRX2_YEAST (P22217) (102 aa) fasta scores: E(): 4.2e-09, 39.130% id in 92 aa, and to Bacillus subtilis probable thioredoxin YdbP TR:P96611 (EMBL:AB001488) (106 aa) fasta scores: E(): 9.9e-23, 57.282% id in 103 aa; thioredoxin 904987 2860883 SAR0862 Staphylococcus aureus subsp. aureus MRSA252 thioredoxin YP_040287.1 904667 R 282458 CDS YP_040288.1 49483064 2860884 905131..905487 1 NC_002952.2 Similar to Bacillus halodurans arsenate reductase BH3485 TR:Q9K785 (EMBL:AP001518) (119 aa) fasta scores: E(): 2.1e-21, 51.304% id in 115 aa, and to Bacillus subtilis hypothetical protein YusI SW:YUSI_BACSU (O32175) (118 aa) fasta scores: E(): 2.4e-21, 51.304% id in 115 aa; hypothetical protein 905487 2860884 SAR0863 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040288.1 905131 D 282458 CDS YP_040289.1 49483065 2860695 905645..906025 1 NC_002952.2 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 906025 gcvH 2860695 gcvH Staphylococcus aureus subsp. aureus MRSA252 glycine cleavage system protein H YP_040289.1 905645 D 282458 CDS YP_040290.1 49483066 2860885 906203..907081 1 NC_002952.2 C-terminus is similar to C-terminal regions of Bacillus subtilis hypothetical protein YwqG TR:P96719 (EMBL:Z92952) (261 aa) fasta scores: E(): 4.1e-07, 31.405% id in 242 aa, and Clostridium acetobutylicum hypothetical protein CAC0820 TR:AAK78796 (EMBL:AE007597) (249 aa) fasta scores: E(): 0.00095, 30.769% id in 247 aa; hypothetical protein 907081 2860885 SAR0865 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040290.1 906203 D 282458 CDS YP_040291.1 49483067 2860886 907672..908058 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YusF TR:O32172 (EMBL:Z99120) (146 aa) fasta scores: E(): 2.4e-14, 42.574% id in 101 aa, and to Vibrio cholerae toxin-coregulated pilus biosynthesis protein H TcpH TR:Q9AGW7 (EMBL:AF325734) (136 aa) fasta scores: E(): 3.4, 25.253% id in 99 aa. CDS is truncated at the N-terminus in comparison to the Bacillus subtilis protein; hypothetical protein 908058 2860886 SAR0867 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040291.1 907672 D 282458 CDS YP_040292.1 49483068 2860887 908051..908347 1 NC_002952.2 Similar to Mycobacterium tuberculosis thioredoxin TrxA SW:THIO_MYCTU (P52229) (115 aa) fasta scores: E(): 0.029, 30.556% id in 72 aa, and to Bacillus subtilis hypothetical protein YusE TR:O32171 (EMBL:Z99120) (106 aa) fasta scores: E(): 2.1e-08, 41.176% id in 85 aa. Lack of similarity at the N-terminus in comparison to Mycobacterium tuberculosis thioredoxin; hypothetical protein 908347 2860887 SAR0868 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040292.1 908051 D 282458 CDS YP_040293.1 49483069 2860888 908597..909622 1 NC_002952.2 Similar to Bacillus halodurans ABC transporter ATP-binding protein BH3481 TR:Q9K789 (EMBL:AP001518) (338 aa) fasta scores: E(): 3.2e-62, 54.734% id in 338 aa, and to Bacillus subtilis hypothetical protein YusC TR:O32169 (EMBL:Z99120) (341 aa) fasta scores: E(): 1.3e-61, 53.824% id in 340 aa; ABC transporter ATP-binding protein 909622 2860888 SAR0870 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040293.1 908597 D 282458 CDS YP_040294.1 49483070 2860889 909615..910310 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YusB TR:O32168 (EMBL:Z99120) (222 aa) fasta scores: E(): 5.4e-46, 64.352% id in 216 aa, and to Bacillus halodurans hypothetical protein BH3480 TR:Q9K790 (EMBL:AP001518) (218 aa) fasta scores: E(): 1.2e-41, 59.447% id in 217 aa; ABC transporter permease 910310 2860889 SAR0871 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_040294.1 909615 D 282458 CDS YP_040295.1 49483071 2860890 910328..911149 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YusA TR:O32167 (EMBL:Z99120) (274 aa) fasta scores: E(): 2.5e-48, 55.839% id in 274 aa, and to Campylobacter jejuni periplasmic protein CJ0772C TR:Q9PPE7 (EMBL:AL139076) (257 aa) fasta scores: E(): 2e-37, 50.207% id in 241 aa; lipoprotein 911149 2860890 SAR0872 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_040295.1 910328 D 282458 CDS YP_040296.1 49483072 2860891 911965..912159 1 NC_002952.2 Similar to Bacillus subtilis sigmaB regulated hypothetical protein CsbD SW:CSBD_BACSU (P70964) (62 aa) fasta scores: E(): 0.0038, 42.553% id in 47 aa, and to Streptococcus pyogenes hypothetical protein SPY1261 TR:Q99ZE6 (EMBL:AE006565) (66 aa) fasta scores: E(): 0.00068, 44.776% id in 67 aa. Similar to SAR1705, 79.661% identity (79.661% ungapped) in 59 aa overlap; hypothetical protein 912159 2860891 SAR0874 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040296.1 911965 D 282458 CDS YP_040297.1 49483073 2860892 complement(912393..913244) 1 NC_002952.2 Similar to an internal region of Staphylococcus carnosus PTS system, glucose-specific IIABC component GlcB TR:Q53922 (EMBL:X93360) (692 aa) fasta scores: E(): 0.74, 25.163% id in 306 aa, and to Bacillus halodurans BH2069 TR:Q9KB62 (EMBL:AP001514) (278 aa) fasta scores: E(): 9.6e-35, 44.528% id in 265 aa; hypothetical protein 913244 2860892 SAR0875 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040297.1 912393 R 282458 CDS YP_040298.1 49483074 2860893 913572..914333 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YurI SW:V296_BACSU (P80866) (260 aa) fasta scores: E(): 3.5e-65, 80.321% id in 249 aa, and to Cyanophora paradoxa probable ATP-dependent transporter Ycf16 SW:ABCX_CYAPA (P48255) (259 aa) fasta scores: E(): 6.5e-44, 56.327% id in 245 aa; ABC transporter ATP-binding protein 914333 2860893 SAR0876 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040298.1 913572 D 282458 CDS YP_040299.1 49483075 2859726 914431..915738 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YurX TR:O32165 (EMBL:Z99120) (437 aa) fasta scores: E(): 7.8e-89, 56.977% id in 430 aa, and to Bacillus halodurans hypothetical protein BH3470 TR:Q9K799 (EMBL:AP001518) (435 aa) fasta scores: E(): 4.3e-83, 53.613% id in 429 aa; hypothetical protein 915738 2859726 SAR0877 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040299.1 914431 D 282458 CDS YP_040300.1 49483076 2859246 915853..917094 1 NC_002952.2 Similar to Escherichia coli selenocysteine lyase CsdB SW:CSDB_ECOLI (P77444) (406 aa) fasta scores: E(): 4.9e-73, 48.148% id in 405 aa, and to Bacillus halodurans probable cysteine desulfurase Csd SW:CSD_BACHD (Q9K7A0) (406 aa) fasta scores: E(): 2.8e-108, 66.585% id in 407 aa; selenocysteine lyase 917094 csdB 2859246 csdB Staphylococcus aureus subsp. aureus MRSA252 selenocysteine lyase YP_040300.1 915853 D 282458 CDS YP_040301.1 49483077 2859911 917084..917548 1 NC_002952.2 Similar to Bacillus subtilis NifU-like protein NifU SW:NIFU_BACSU (O32163) (147 aa) fasta scores: E(): 3.5e-37, 70.548% id in 146 aa, and to Bacillus halodurans nitrogen fixation protein BH3468 TR:Q9K7A1 (EMBL:AP001518) (146 aa) fasta scores: E(): 1.3e-34, 64.626% id in 147 aa; NifU-like protein 917548 2859911 SAR0879 Staphylococcus aureus subsp. aureus MRSA252 NifU-like protein YP_040301.1 917084 D 282458 CDS YP_040302.1 49483078 2859912 917699..919096 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YurU TR:O32162 (EMBL:Z99120) (465 aa) fasta scores: E(): 1.2e-157, 84.516% id in 465 aa, and to Bacillus halodurans hypothetical protein BH3467 TR:Q9K7A2 (EMBL:AP001518) (465 aa) fasta scores: E(): 2.5e-154, 82.366% id in 465 aa; hypothetical protein 919096 2859912 SAR0880 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040302.1 917699 D 282458 CDS YP_040303.1 49483079 2861688 complement(919428..919742) 1 NC_002952.2 hypothetical protein 919742 2861688 SAR0881 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040303.1 919428 R 282458 CDS YP_040304.1 49483080 2861689 920111..921151 1 NC_002952.2 Similar to the N-terminal regions of Vibrio cholerae hemolysin VC0558 TR:Q9KUG3 (EMBL:AE004141) (426 aa) fasta scores: E(): 7.1e-26, 28.446% id in 341 aa, and Thermotoga maritima hemolysin-related protein TM0845 TR:Q9WZU9 (EMBL:AE001751) (455 aa) fasta scores: E(): 7.9e-27, 34.024% id in 338 aa; hypothetical protein 921151 2861689 SAR0882 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040304.1 920111 D 282458 CDS YP_040305.1 49483081 2861690 921165..922232 1 NC_002952.2 Similar to Williopsis mrakii 2-nitropropane dioxygenase SW:2NPD_WILMR (Q12723) (374 aa) fasta scores: E(): 2e-13, 30.240% id in 334 aa, and to Bacillus halodurans hypothetical protein BH1205 TR:Q9KDK7 (EMBL:AP001511) (365 aa) fasta scores: E(): 1.7e-46, 44.857% id in 350 aa; dioxygenase 922232 2861690 SAR0883 Staphylococcus aureus subsp. aureus MRSA252 dioxygenase YP_040305.1 921165 D 282458 CDS YP_040306.1 49483082 2861691 922532..923380 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YunF TR:O32135 (EMBL:Z99120) (284 aa) fasta scores: E(): 9.7e-60, 53.004% id in 283 aa, and to Bacillus halodurans hypothetical protein BH3455 TR:Q9K7B1 (EMBL:AP001518) (282 aa) fasta scores: E(): 2.6e-56, 50.177% id in 283 aa; hypothetical protein 923380 2861691 SAR0884 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040306.1 922532 D 282458 CDS YP_040307.1 49483083 2861692 923393..924220 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YunE TR:O32134 (EMBL:Z99120) (273 aa) fasta scores: E(): 7.3e-42, 41.544% id in 272 aa, and to Bacillus halodurans hypothetical protein BH3454 TR:Q9K7B2 (EMBL:AP001518) (273 aa) fasta scores: E(): 1.9e-41, 43.939% id in 264 aa; hypothetical protein 924220 2861692 SAR0885 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040307.1 923393 D 282458 CDS YP_040308.1 49483084 2861693 924247..925566 1 NC_002952.2 N-terminus is similar to the N-terminal region of Boophilus microplus 5'-nucleotidase precursor protein SW:5NTD_BOOMI (P52307) (580 aa) fasta scores: E(): 2.8e-05, 22.302% id in 417 aa. Full length CDS is similar to Lactococcus lactis hypothetical protein YbiB TR:Q9CJ29 (EMBL:AE006255) (447 aa) fasta scores: E(): 2.6e-50, 36.585% id in 451 aa; 5'-nucleotidase 925566 2861693 SAR0886 Staphylococcus aureus subsp. aureus MRSA252 5'-nucleotidase YP_040308.1 924247 D 282458 CDS YP_040309.1 49483085 2859805 925650..926567 1 NC_002952.2 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 926567 lipA 2859805 lipA Staphylococcus aureus subsp. aureus MRSA252 lipoyl synthase YP_040309.1 925650 D 282458 CDS YP_040310.1 49483086 2861694 926696..927079 1 NC_002952.2 N-terminus is similar to Bacillus halodurans hypothetical protein BH3433 TR:Q9K7D1 (EMBL:AP001518) (93 aa) fasta scores: E(): 4.5e-19, 53.261% id in 92 aa, and to Bacillus subtilis hypothetical protein YutD TR:O32127 (EMBL:Z99120) (102 aa) fasta scores: E(): 1.4e-18, 58.242% id in 91 aa; hypothetical protein 927079 2861694 SAR0888 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040310.1 926696 D 282458 CDS YP_040311.1 49483087 2861695 complement(927158..927424) 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans hypothetical protein BH3432 TR:Q9K7D2 (EMBL:AP001518) (88 aa) fasta scores: E(): 4.3e-15, 50.602% id in 83 aa; hypothetical protein 927424 2861695 SAR0889 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040311.1 927158 R 282458 CDS YP_040312.1 49483088 2861696 927522..927956 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3430 TR:Q9K7D4 (EMBL:AP001518) (151 aa) fasta scores: E(): 6.2e-15, 37.762% id in 143 aa, and to Bacillus subtilis hypothetical protein YutE TR:O32126 (EMBL:Z99120) (144 aa) fasta scores: E(): 7.4e-11, 33.566% id in 143 aa; hypothetical protein 927956 2861696 SAR0890 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040312.1 927522 D 282458 CDS YP_040313.1 49483089 2861697 927956..928735 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YutF TR:O32125 (EMBL:Z99120) (256 aa) fasta scores: E(): 2.4e-45, 53.543% id in 254 aa, and to Streptococcus pyogenes hypothetical protein SPY1043 TR:Q99ZW4 (EMBL:AE006549) (254 aa) fasta scores: E(): 3e-38, 48.000% id in 250 aa; haloacid dehalogenase-like hydrolase 928735 2861697 SAR0891 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_040313.1 927956 D 282458 CDS YP_040314.1 49483090 2861698 928768..929727 1 NC_002952.2 Similar to Bacillus halodurans glycerate dehydrogenase BH3314 TR:Q9K7P7 (EMBL:AP001518) (324 aa) fasta scores: E(): 4.6e-52, 45.066% id in 304 aa, and to Pyrococcus abyssi glycerate dehydrogenase PAB2374 TR:Q9UYR1 (EMBL:AJ248287) (335 aa) fasta scores: E(): 5e-49, 41.745% id in 321 aa; D-isomer specific 2-hydroxyacid dehydrogenase 929727 2861698 SAR0892 Staphylococcus aureus subsp. aureus MRSA252 D-isomer specific 2-hydroxyacid dehydrogenase YP_040314.1 928768 D 282458 CDS YP_040315.1 49483091 2861699 930138..930290 1 NC_002952.2 hypothetical protein 930290 2861699 SAR0893 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040315.1 930138 D 282458 CDS YP_040316.1 49483092 2859593 930306..931763 1 NC_002952.2 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 931763 dltA 2859593 dltA Staphylococcus aureus subsp. aureus MRSA252 D-alanine--poly(phosphoribitol) ligase subunit 1 YP_040316.1 930306 D 282458 CDS YP_040317.1 49483093 2859594 931760..932974 1 NC_002952.2 Similar to Bacillus subtilis activated D-alanine transport protein DltB SW:DLTB_BACSU (P39580) (395 aa) fasta scores: E(): 3.1e-68, 52.334% id in 407 aa. Previously sequenced as Staphylococcus aureus hypothetical membrane transporter DltB TR:Q53662 (EMBL:D86240) (404 aa) fasta scores: E(): 1e-158, 100.000% id in 404 aa; activated D-alanine transport protein 932974 dltB 2859594 dltB Staphylococcus aureus subsp. aureus MRSA252 activated D-alanine transport protein YP_040317.1 931760 D 282458 CDS YP_040318.1 49483094 2859595 932992..933228 1 NC_002952.2 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 933228 dltC 2859595 dltC Staphylococcus aureus subsp. aureus MRSA252 D-alanine--poly(phosphoribitol) ligase subunit 2 YP_040318.1 932992 D 282458 CDS YP_040319.1 49483095 2859596 933225..934400 1 NC_002952.2 Similar to Bacillus subtilis lipoteichoic acid biosynthesis protein DltD SW:DLTD_BACSU (P39578) (392 aa) fasta scores: E(): 1.2e-40, 32.216% id in 388 aa. Previously sequenced as Staphylococcus aureus exoprotein DltD TR:Q9S674 (EMBL:AF101234) (391 aa) fasta scores: E(): 3.5e-147, 100.000% id in 391 aa; lipoteichoic acid biosynthesis protein 934400 dltD 2859596 dltD Staphylococcus aureus subsp. aureus MRSA252 lipoteichoic acid biosynthesis protein YP_040319.1 933225 D 282458 CDS YP_040320.1 49483096 2861700 complement(934662..934904) 1 NC_002952.2 Similar to Bacillus halodurans nitrogen fixation protein BH3419 TR:Q9K7E5 (EMBL:AP001518) (79 aa) fasta scores: E(): 1.1e-20, 77.333% id in 75 aa, and to Synechocystis sp hypothetical protein SSL2667 TR:P74558 (EMBL:D90916) (76 aa) fasta scores: E(): 1.6e-12, 51.389% id in 72 aa; hypothetical protein 934904 2861700 SAR0898 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040320.1 934662 R 282458 CDS YP_040321.1 49483097 2861701 935005..935328 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YuzD TR:O32118 (EMBL:Z99120) (108 aa) fasta scores: E(): 1.9e-14, 43.925% id in 107 aa, and to Bacillus halodurans hypothetical protein BH3416 TR:Q9K7E6 (EMBL:AP001518) (101 aa) fasta scores: E(): 1.3e-10, 37.755% id in 98 aa; hypothetical protein 935328 2861701 SAR0899 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040321.1 935005 D 282458 CDS YP_040322.1 49483098 2861702 complement(935388..936452) 1 NC_002952.2 Similar to Bacillus subtilis YutJ TR:O32117 (EMBL:Z99120) (330 aa) fasta scores: E(): 6.1e-70, 54.799% id in 323 aa, and to Sulfolobus solfataricus NADH oxidase SSO3148 TR:AAK43249 (EMBL:AE006905) (350 aa) fasta scores: E(): 3.2e-12, 26.087% id in 345 aa; pyridine nucleotide-disulfide oxidoreductase 936452 2861702 SAR0900 Staphylococcus aureus subsp. aureus MRSA252 pyridine nucleotide-disulfide oxidoreductase YP_040322.1 935388 R 282458 CDS YP_040323.1 49483099 2861703 936769..937005 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YuzB TR:O32116 (EMBL:Z99120) (78 aa) fasta scores: E(): 1.5e-16, 53.846% id in 78 aa, and to Bacillus halodurans hypothetical protein BH3414 TR:Q9K7E8 (EMBL:AP001518) (78 aa) fasta scores: E(): 1.8e-15, 50.000% id in 78 aa; hypothetical protein 937005 2861703 SAR0901 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040323.1 936769 D 282458 CDS YP_040324.1 49483100 2861704 937018..937377 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YutM SW:YUTM_BACSU (O32113) (120 aa) fasta scores: E(): 5.7e-26, 59.483% id in 116 aa, and to Bacillus halodurans hypothetical protein BH3410 TR:Q9K7F2 (EMBL:AP001518) (117 aa) fasta scores: E(): 1.1e-21, 52.137% id in 117 aa; hypothetical protein 937377 2861704 SAR0902 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040324.1 937018 D 282458 CDS YP_040325.1 49483101 2861705 937831..939039 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YumB TR:O05267 (EMBL:Z93939) (406 aa) fasta scores: E(): 1.5e-77, 52.723% id in 404 aa, and to Bacillus halodurans NADH dehydrogenase BH3407 TR:Q9K7F4 (EMBL:AP001518) (400 aa) fasta scores: E(): 1.7e-65, 47.750% id in 400 aa; pyridine nucleotide-disulfide oxidoreductase 939039 2861705 SAR0903 Staphylococcus aureus subsp. aureus MRSA252 pyridine nucleotide-disulfide oxidoreductase YP_040325.1 937831 D 282458 CDS YP_040326.1 49483102 2859893 939170..940645 1 NC_002952.2 Similar to Pseudomonas aeruginosa cytosol aminopeptidase PepA SW:AMPA_PSEAE (O68822) (495 aa) fasta scores: E(): 3.9e-46, 36.504% id in 452 aa, and to Bacillus subtilis probable cytosol aminopeptidase pepA SW:AMPA_BACSU (O32106) (500 aa) fasta scores: E(): 8e-51, 35.185% id in 486 aa; cytosol aminopeptidase 940645 pepA 2859893 pepA Staphylococcus aureus subsp. aureus MRSA252 cytosol aminopeptidase YP_040326.1 939170 D 282458 CDS YP_040327.1 49483103 2861706 941056..942372 1 NC_002952.2 Similar to Escherichia coli high-affinity gluconate transporter GntT SW:GNTT_ECOLI (P39835) (437 aa) fasta scores: E(): 1.3e-05, 20.844% id in 403 aa, and to Bacillus halodurans hypothetical protein BH3359 TR:Q9K7K2 (EMBL:AP001518) (440 aa) fasta scores: E(): 2.3e-78, 49.091% id in 440 aa; transporter protein 942372 2861706 SAR0905 Staphylococcus aureus subsp. aureus MRSA252 transporter protein YP_040327.1 941056 D 282458 CDS YP_040328.1 49483104 2861707 942391..942765 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YuxO TR:Q9FAE9 (EMBL:AB039951) (127 aa) fasta scores: E(): 2.8e-16, 47.863% id in 117 aa, and to C-terminal region of Pseudomonas aeruginosa hypothetical protein PA1618 SW:YG18_PSEAE (Q9I3A4) (145 aa) fasta scores: E(): 3.2e-16, 44.444% id in 108 aa; hypothetical protein 942765 2861707 SAR0906 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040328.1 942391 D 282458 CDS YP_040329.1 49483105 2861708 complement(942821..943975) 1 NC_002952.2 Poor database matches. N-terminus is similar to the N-terminal regions of Bacillus subtilis hypothetical protein YrdP TR:O07085 (EMBL:U93876) (345 aa) fasta scores: E(): 5, 22.508% id in 311 aa, and Mycobacterium tuberculosis monooxygenase Rv1393c TR:P71662 (EMBL:Z80108) (492 aa) fasta scores: E(): 8, 22.843% id in 197 aa; hypothetical protein 943975 2861708 SAR0907 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040329.1 942821 R 282458 CDS YP_040330.1 49483106 2861172 complement(944238..944594) 1 NC_002952.2 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit G 944594 mnhG 2861172 mnhG Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit G YP_040330.1 944238 R 282458 CDS YP_040331.1 49483107 2861171 complement(944572..944865) 1 NC_002952.2 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit F 944865 mnhF 2861171 mnhF Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit F YP_040331.1 944572 R 282458 CDS YP_040332.1 49483108 2861170 complement(944865..945344) 1 NC_002952.2 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit E 945344 mnhE 2861170 mnhE Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit E YP_040332.1 944865 R 282458 CDS YP_040333.1 49483109 2861169 complement(945346..946842) 1 NC_002952.2 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; monovalent cation/H+ antiporter subunit D 946842 mnhD 2861169 mnhD Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit D YP_040333.1 945346 R 282458 CDS YP_040334.1 49483110 2861168 complement(946835..947176) 1 NC_002952.2 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit C 947176 mnhC 2861168 mnhC Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit C YP_040334.1 946835 R 282458 CDS YP_040335.1 49483111 2861167 complement(947176..947604) 1 NC_002952.2 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in the case of S. meliloti it was proved to be involved specifically with K+ transport; monovalent cation/H+ antiporter subunit B 947604 mnhB 2861167 mnhB Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit B YP_040335.1 947176 R 282458 CDS YP_040336.1 49483112 2861166 complement(947597..950002) 1 NC_002952.2 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit A 950002 mnhA 2861166 mnhA Staphylococcus aureus subsp. aureus MRSA252 monovalent cation/H+ antiporter subunit A YP_040336.1 947597 R 282458 CDS YP_040337.1 49483113 2861709 complement(950133..950516) 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis kinase-associated protein B KapB SW:KAPB_BACSU (Q08429) (128 aa) fasta scores: E(): 3.2e-08, 36.036% id in 111 aa. Previously sequenced as Staphylococcus aureus hypothetical protein OrfA TR:Q9ZNG7 (EMBL:AB015981) (127 aa) fasta scores: E(): 7.5e-45, 99.213% id in 127 aa; hypothetical protein 950516 2861709 SAR0915 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040337.1 950133 R 282458 CDS YP_040338.1 49483114 2861710 950580..951173 1 NC_002952.2 Similar to Caenorhabditis elegans cyclophilin isoform 10, peptidyl-prolyl cis-trans isomerase 10, CYP-10 SW:CYPA_CAEEL (P52017) (147 aa) fasta scores: E(): 8.2e-17, 42.105% id in 171 aa, and to Lactococcus lactis peptidyl-prolyl cis-trans isomerase PpiB TR:Q9CH46 (EMBL:AE006323) (196 aa) fasta scores: E(): 7.7e-43, 60.204% id in 196 aa; cyclophilin type peptidyl-prolyl cis-trans isomerase 951173 2861710 SAR0916 Staphylococcus aureus subsp. aureus MRSA252 cyclophilin type peptidyl-prolyl cis-trans isomerase YP_040338.1 950580 D 282458 CDS YP_040339.1 49483115 2861711 951588..951965 1 NC_002952.2 Similar to Bacillus subtilis general stress protein 13 YugI SW:GS13_BACSU (P80870) (129 aa) fasta scores: E(): 2.7e-09, 35.000% id in 120 aa, and to Bacillus halodurans polyribonucleotide nucleotidyltransferase BH3347 TR:Q9K7L4 (EMBL:AP001518) (138 aa) fasta scores: E(): 1.3e-09, 36.364% id in 132 aa; S1 RNA-binding domain-containing protein 951965 2861711 SAR0917 Staphylococcus aureus subsp. aureus MRSA252 S1 RNA-binding domain-containing protein YP_040339.1 951588 D 282458 CDS YP_040340.1 49483116 2861712 952327..953454 1 NC_002952.2 Similar to the N-terminal region of Thermoanaerobacter brockii NADH oxidase SW:NADO_THEBR (P32382) (651 aa) fasta scores: E(): 2.2e-25, 32.670% id in 352 aa, and to Bacillus subtilis probable NADH-dependent flavin oxidoreductase YqiG SW:YQIG_BACSU (P54524) (372 aa) fasta scores: E(): 3.3e-62, 47.354% id in 378 aa; NADH:flavin oxidoreductase / NADH oxidase 953454 2861712 SAR0918 Staphylococcus aureus subsp. aureus MRSA252 NADH:flavin oxidoreductase / NADH oxidase YP_040340.1 952327 D 282458 CDS YP_040341.1 49483117 2859280 953762..954952 1 NC_002952.2 Similar to Bacillus subtilis ornithine aminotransferase RocD SW:OAT_BACSU (P38021) (401 aa) fasta scores: E(): 3.6e-115, 73.990% id in 396 aa, and to Bacillus halodurans ornithine aminotransferase RocD TR:Q9K5Z2 (EMBL:AP001520) (400 aa) fasta scores: E(): 2.4e-109, 71.646% id in 395 aa. Similar to SAR0186, 57.179% identity (57.179% ungapped) in 390 aa overlap; ornithine--oxo-acid transaminase 954952 rocD 2859280 rocD Staphylococcus aureus subsp. aureus MRSA252 ornithine--oxo-acid transaminase YP_040341.1 953762 D 282458 CDS YP_040342.1 49483118 2861713 955061..956305 1 NC_002952.2 Similar to Bacillus subtilis NAD-specific glutamate dehydrogenase RocG SW:DHE2_BACSU (P39633) (424 aa) fasta scores: E(): 6.7e-124, 73.479% id in 411 aa, and to Bacillus halodurans glutamate dehydrogenase BH1622 TR:Q9KCE9 (EMBL:AP001512) (421 aa) fasta scores: E(): 1.2e-126, 75.669% id in 411 aa; NAD-specific glutamate dehydrogenase 956305 2861713 SAR0920 Staphylococcus aureus subsp. aureus MRSA252 NAD-specific glutamate dehydrogenase YP_040342.1 955061 D 282458 CDS YP_040343.1 49483119 2859928 complement(956700..957629) 1 NC_002952.2 Similar to Bacillus subtilis glycerophosphoryl diester phosphodiesterase GlpQ SW:GLPQ_BACSU (P37965) (293 aa) fasta scores: E(): 6.5e-52, 54.023% id in 261 aa, and to Bacillus halodurans glycerophosphoryl diester phosphodiesterase GlpQ TR:Q9K6M8 (EMBL:AP001519) (284 aa) fasta scores: E(): 1.8e-19, 39.041% id in 292 aa; glycerophosphoryl diester phosphodiesterase 957629 glpQ 2859928 glpQ Staphylococcus aureus subsp. aureus MRSA252 glycerophosphoryl diester phosphodiesterase YP_040343.1 956700 R 282458 CDS YP_040344.1 49483120 2859854 complement(957871..959250) 1 NC_002952.2 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 959250 argH 2859854 argH Staphylococcus aureus subsp. aureus MRSA252 argininosuccinate lyase YP_040344.1 957871 R 282458 CDS YP_040345.1 49483121 2859853 complement(959240..960445) 1 NC_002952.2 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 960445 argG 2859853 argG Staphylococcus aureus subsp. aureus MRSA252 argininosuccinate synthase YP_040345.1 959240 R 282458 CDS YP_040346.1 49483122 2861714 960796..962127 1 NC_002952.2 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 962127 pgi 2861714 pgi Staphylococcus aureus subsp. aureus MRSA252 glucose-6-phosphate isomerase YP_040346.1 960796 D 282458 CDS YP_040347.1 49483123 2861715 962453..963028 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhjE TR:O07559 (EMBL:Y14081) (207 aa) fasta scores: E(): 9e-22, 33.161% id in 193 aa, and to Staphylococcus carnosus hypothetical protein TR:Q9ZG07 (EMBL:AF089862) (225 aa) fasta scores: E(): 2.5e-31, 41.398% id in 186 aa. CDS is truncated at the N-terminus in comparison to other orthologues; hypothetical protein 963028 2861715 SAR0925 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040347.1 962453 D 282458 CDS YP_040348.1 49483124 2859159 963033..963557 1 NC_002952.2 Similar to Bacillus subtilis signal peptidase I SipS SW:LEPS_BACSU (P28628) (184 aa) fasta scores: E(): 1.9e-12, 28.655% id in 171 aa. Previously sequenced as Staphylococcus aureus inactive signal peptidase Ia SpsA SW:LEPH_STAAU (P72364) (174 aa) fasta scores: E(): 2.5e-64, 98.851% id in 174 aa. The Staphylococcus aureus signal peptidase I is thought to be inactive as it lacks essential catalytic residues; signal peptidase Ia 963557 spsA 2859159 spsA Staphylococcus aureus subsp. aureus MRSA252 signal peptidase Ia YP_040348.1 963033 D 282458 CDS YP_040349.1 49483125 2859160 963573..964148 1 NC_002952.2 Previously sequenced as Staphylococcus aureus signal peptidase Ib SpsB SW:LEP_STAAU (P72365) (191 aa) fasta scores: E(): 6.3e-72, 98.953% id in 191 aa. Similar to Staphylococcus carnosus type-I signal peptidase SipB TR:Q9ZG05 (EMBL:AF089862) (189 aa) fasta scores: E(): 6.8e-51, 70.588% id in 187 aa; signal peptidase Ib 964148 spsB 2859160 spsB Staphylococcus aureus subsp. aureus MRSA252 signal peptidase Ib YP_040349.1 963573 D 282458 CDS YP_040350.1 49483126 2861716 964308..967784 1 NC_002952.2 Similar to Bacillus subtilis ATP-dependent nuclease subunit B AddB SW:ADDB_BACSU (P23477) (1166 aa) fasta scores: E(): 2.5e-21, 31.014% id in 1164 aa, and to Lactococcus lactis subunit B of ATP-dependent exonuclease RexB TR:Q9CJJ0 (EMBL:AE006239) (1099 aa) fasta scores: E(): 1e-15, 21.303% id in 1136 aa; hypothetical protein 967784 2861716 SAR0928 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040350.1 964308 D 282458 CDS YP_040351.1 49483127 2861717 967785..971438 1 NC_002952.2 Similar to Bacillus subtilis ATP-dependent nuclease subunit A AddA SW:ADDA_BACSU (P23478) (1232 aa) fasta scores: E(): 2.3e-94, 37.070% id in 1249 aa, and to Lactococcus lactis subunit A of ATP-dependent exonuclease RexA TR:Q9CJI9 (EMBL:AE006239) (1203 aa) fasta scores: E(): 1e-72, 29.841% id in 1260 aa; hypothetical protein 971438 2861717 SAR0929 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040351.1 967785 D 282458 CDS YP_040352.1 49483128 2861718 971604..972506 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YisK TR:O06724 (EMBL:Y09476) (301 aa) fasta scores: E(): 4e-39, 40.924% id in 303 aa, and to Bacillus halodurans 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase BH2000 TR:Q9KBC8 (EMBL:AP001514) (319 aa) fasta scores: E(): 1.5e-29, 34.936% id in 312 aa; fumarylacetoacetate (FAA) hydrolase 972506 2861718 SAR0930 Staphylococcus aureus subsp. aureus MRSA252 fumarylacetoacetate (FAA) hydrolase YP_040352.1 971604 D 282458 CDS YP_040353.1 49483129 2861719 972832..973221 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YisL TR:O06725 (EMBL:Y09476) (118 aa) fasta scores: E(): 4.4e-09, 34.711% id in 121 aa, and to Bacillus halodurans hypothetical protein BH2983 TR:Q9K8M3 (EMBL:AP001517) (124 aa) fasta scores: E(): 0.0033, 27.193% id in 114 aa; hypothetical protein 973221 2861719 SAR0931 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040353.1 972832 D 282458 CDS YP_040354.1 49483130 2861720 973598..975244 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 5e-197, 98.540% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 2.3e-97, 51.346% id in 520 aa; transposase 975244 2861720 SAR0932 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040354.1 973598 D 282458 CDS YP_040355.1 49483131 2861721 complement(975316..976632) 1 NC_002952.2 NADPH-dependent; catalyzes the reduction of coenzyme A disulfide; coenzyme A disulfide reductase 976632 2861721 SAR0933 Staphylococcus aureus subsp. aureus MRSA252 coenzyme A disulfide reductase YP_040355.1 975316 R 282458 CDS YP_040356.1 49483132 2861722 complement(976684..977508) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YitU TR:P70947 (EMBL:Z79580) (270 aa) fasta scores: E(): 1.1e-48, 47.191% id in 267 aa, and to Bacillus halodurans BH2906 TR:Q9K8U6 (EMBL:AP001517) (269 aa) fasta scores: E(): 8.2e-48, 49.064% id in 267 aa; haloacid dehalogenase-like hydrolase 977508 2861722 SAR0934 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_040356.1 976684 R 282458 CDS YP_040357.1 49483133 2861723 977622..977930 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YitW TR:P70949 (EMBL:Z79580) (102 aa) fasta scores: E(): 1.1e-27, 68.317% id in 101 aa, and to Bacillus halodurans hypothetical protein BH2173 TR:Q9KAW3 (EMBL:AP001514) (111 aa) fasta scores: E(): 2.7e-21, 66.000% id in 100 aa; hypothetical protein 977930 2861723 SAR0935 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040357.1 977622 D 282458 CDS YP_040358.1 49483134 2859419 complement(977943..978068) 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 978068 2859419 SAR0936 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040358.1 977943 R 282458 CDS YP_040359.1 49483135 2859420 978510..980324 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YrhL TR:O05402 (EMBL:U93874) (634 aa) fasta scores: E(): 8.8e-52, 38.328% id in 634 aa, and to Lactococcus lactis hypothetical protein YvhB TR:Q9CDV4 (EMBL:AE006439) (605 aa) fasta scores: E(): 5.4e-42, 33.223% id in 605 aa. Simililar to SAR2649, 57.475% identity (58.545% ungapped) in 602 aa overlap; hypothetical protein 980324 2859420 SAR0937 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040359.1 978510 D 282458 CDS YP_040360.1 49483136 2859233 980527..983136 1 NC_002952.2 Similar to Escherichia coli ATPase subunit of an ATP-dependent protease, and heat shock protein, ClpB SW:CLPB_ECOLI (P03815) (857 aa) fasta scores: E(): 1.5e-128, 52.723% id in 863 aa, and to Lactococcus lactis ClpB homologue TR:Q9CFF3 (EMBL:AE006383) (867 aa) fasta scores: E(): 2.4e-156, 60.596% id in 873 aa. Contains coiled-coiled domain, residues 440 to 485; ATPase of an ATP-dependent protease 983136 clpB 2859233 clpB Staphylococcus aureus subsp. aureus MRSA252 ATPase of an ATP-dependent protease YP_040360.1 980527 D 282458 CDS YP_040361.1 49483137 2859421 complement(983195..984064) 1 NC_002952.2 N-terminus is similar the N-terminal region of Bacillus subtilis citrate synthase I repressor CitR SW:CITR_BACSU (P39127) (308 aa) fasta scores: E(): 1.9e-15, 26.016% id in 246 aa. Full length CDS is similar to Bacillus subtilis hypothetical transcriptional regulator YxjO SW:YXJO_BACSU (P55181) (291 aa) fasta scores: E(): 2.2e-27, 29.010% id in 293 aa; LysR family regulatory protein 984064 2859421 SAR0939 Staphylococcus aureus subsp. aureus MRSA252 LysR family regulatory protein YP_040361.1 983195 R 282458 CDS YP_040362.1 49483138 2859422 984175..985320 1 NC_002952.2 Similar to the N-terminal regions of Lactococcus lactis 2-isopropylmalate synthase LeuA SW:LEU1_LACLA (Q02141) (513 aa) fasta scores: E(): 2.2e-29, 33.777% id in 376 aa, and Bacillus subtilis 2-isopropylmalate synthase LeuA SW:LEU1_BACSU (P94565) (518 aa) fasta scores: E(): 2.6e-28, 33.422% id in 377 aa; hypothetical protein 985320 2859422 SAR0940 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040362.1 984175 D 282458 CDS YP_040363.1 49483139 2859423 985304..985945 1 NC_002952.2 Similar to the N-terminal regions of Archaeoglobus fulgidus conserved hypothetical protein AF0781 TR:O29477 (EMBL:AE001051) (309 aa) fasta scores: E(): 8.5e-10, 25.962% id in 208 aa, and Pyrococcus horikoshii hypothetical protein PH0435 TR:O73972 (EMBL:AP000002) (340 aa) fasta scores: E(): 4.5e-09, 32.812% id in 192 aa; hypothetical protein 985945 2859423 SAR0941 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040363.1 985304 D 282458 CDS YP_040364.1 49483140 2859424 985938..987056 1 NC_002952.2 Poor database matches. Similar to Helicobacter pylori hypothetical protein TR:Q9F7U3 (EMBL:AF275307) (387 aa) fasta scores: E(): 0.078, 25.575% id in 348 aa; hypothetical protein 987056 2859424 SAR0942 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040364.1 985938 D 282458 CDS YP_040365.1 49483141 2859425 987040..987555 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YxkA TR:P94355 (EMBL:D83026) (168 aa) fasta scores: E(): 4.5e-26, 46.875% id in 160 aa, and to Pasteurella multocida hypothetical protein PM1470 TR:Q9CKY1 (EMBL:AE006183) (170 aa) fasta scores: E(): 2e-17, 44.286% id in 140 aa; hypothetical protein 987555 2859425 SAR0943 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040365.1 987040 D 282458 CDS YP_040366.1 49483142 2859426 987866..988300 1 NC_002952.2 Poor database matches. Similar to N-terminal region of Staphylococcus aureus MHC class II analogue TR:Q53599 (EMBL:U20503) (689 aa) fasta scores: E(): 9.7e-11, 45.946% id in 148 aa; hypothetical protein 988300 2859426 SAR0944 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040366.1 987866 D 282458 CDS YP_040367.1 49483143 2859427 complement(988557..988742) 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis YjzD TR:O34713 (EMBL:Z99109) (61 aa) fasta scores: E(): 0.3, 22.951% id in 61 aa; hypothetical protein 988742 2859427 SAR0945 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040367.1 988557 R 282458 CDS YP_040368.1 49483144 2859620 989038..989979 1 NC_002952.2 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 989979 fabH 2859620 fabH Staphylococcus aureus subsp. aureus MRSA252 3-oxoacyl-ACP synthase YP_040368.1 989038 D 282458 CDS YP_040369.1 49483145 2859618 989991..991235 1 NC_002952.2 Similar to Vibrio harveyi 3-oxoacyl-[acyl-carrier-protein] synthase II FabF SW:FABF_VIBHA (P55338) (414 aa) fasta scores: E(): 4.9e-78, 52.206% id in 408 aa, and to Bacillus subtilis hypothetical protein YjaY TR:O34340 (EMBL:Z99109) (413 aa) fasta scores: E(): 4.7e-106, 67.971% id in 409 aa; 3-oxoacyl-ACP synthase 991235 fabF 2859618 fabF Staphylococcus aureus subsp. aureus MRSA252 3-oxoacyl-ACP synthase YP_040369.1 989991 D 282458 CDS YP_040370.1 49483146 2859428 complement(991290..991661) 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 991661 2859428 SAR0948 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040370.1 991290 R 282458 CDS YP_040371.1 49483147 2859181 991904..992830 1 NC_002952.2 Similar to Bacillus subtilis oligopeptide ABC transporter permease OppB SW:OPPB_BACSU (P24138) (311 aa) fasta scores: E(): 1.9e-55, 49.515% id in 309 aa, and to Bacillus thuringiensis hypothetical protein OppB TR:Q9F5U5 (EMBL:AF305387) (309 aa) fasta scores: E(): 4.5e-69, 60.194% id in 309 aa; oligopeptide ABC transporter permease 992830 oppB 2859181 oppB Staphylococcus aureus subsp. aureus MRSA252 oligopeptide ABC transporter permease YP_040371.1 991904 D 282458 CDS YP_040372.1 49483148 2859182 992830..993900 1 NC_002952.2 Similar to Bacillus subtilis oligopeptide ABC transporter permease OppC SW:OPPC_BACSU (P24139) (305 aa) fasta scores: E(): 2.4e-48, 46.815% id in 314 aa, and to Bacillus thuringiensis hypothetical protein OppC TR:Q9F5U4 (EMBL:AF305387) (337 aa) fasta scores: E(): 2.7e-72, 56.869% id in 313 aa; oligopeptide ABC transporter permease 993900 oppC 2859182 oppC Staphylococcus aureus subsp. aureus MRSA252 oligopeptide ABC transporter permease YP_040372.1 992830 D 282458 CDS YP_040373.1 49483149 2859183 993916..994998 1 NC_002952.2 Similar to Bacillus subtilis oligopeptide transport ATP-binding protein OppD SW:OPPD_BACSU (P24136) (358 aa) fasta scores: E(): 1.4e-80, 67.045% id in 352 aa, and to Listeria monocytogenes oligopeptide transport system ATPase OppD TR:Q9LAT4 (EMBL:AF103793) (358 aa) fasta scores: E(): 4.5e-78, 67.456% id in 338 aa. Similar to SAR0198, 50.763% identity (50.763% ungapped) in 262 aa overlap; oligopeptide transport ATP-binding protein 994998 oppD 2859183 oppD Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transport ATP-binding protein YP_040373.1 993916 D 282458 CDS YP_040374.1 49483150 2859184 994988..995929 1 NC_002952.2 Similar to Bacillus subtilis oligopeptide transport ATP-binding protein OppF SW:OPPF_BACSU (P24137) (308 aa) fasta scores: E(): 2e-69, 66.890% id in 299 aa, and to Listeria monocytogenes oligopeptide transport system ATPase OppF TR:Q9LAT3 (EMBL:AF103793) (325 aa) fasta scores: E(): 6e-66, 63.407% id in 317 aa. Similar to SAR0958, 54.198% identity (55.686% ungapped) in 262 aa overlap; oligopeptide transport ATP-binding protein 995929 oppF 2859184 oppF Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transport ATP-binding protein YP_040374.1 994988 D 282458 CDS YP_040375.1 49483151 2859429 995948..997603 1 NC_002952.2 Similar to Listeria monocytogenes peptide binding protein OppA TR:Q9LAT7 (EMBL:AF103793) (558 aa) fasta scores: E(): 1.3e-72, 40.182% id in 550 aa, and to Bacillus thuringiensis hypothetical protein OppA TR:Q9F5U6 (EMBL:AF305387) (551 aa) fasta scores: E(): 4.9e-68, 37.658% id in 555 aa; transport system extracellular binding lipoprotein 997603 2859429 SAR0953 Staphylococcus aureus subsp. aureus MRSA252 transport system extracellular binding lipoprotein YP_040375.1 995948 D 282458 CDS YP_040376.1 49483152 2859431 complement(998073..999020) 1 NC_002952.2 Identical to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 2.7e-127, 100.000% id in 315 aa, and similar to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 2.9e-71, 58.413% id in 315 aa; transposase 999020 2859431 SAR0955 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040376.1 998073 R 282458 CDS YP_040377.1 49483153 2860992 1000655..1001641 1 NC_002952.2 Similar to Bacillus subtilis oligopeptide transport ATP-binding protein AppD SW:APPD_BACSU (P42064) (328 aa) fasta scores: E(): 5.4e-48, 47.546% id in 326 aa, and to Bacillus halodurans oligopeptide ABC transporter BH3646 TR:Q9K6T0 (EMBL:AP001519) (329 aa) fasta scores: E(): 3.8e-57, 52.280% id in 329 aa; oligopeptide transport ATP-binding protein 1001641 appD 2860992 appD Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transport ATP-binding protein YP_040377.1 1000655 D 282458 CDS YP_040378.1 49483154 2860993 1001644..1002624 1 NC_002952.2 Similar to Bacillus subtilis oligopeptide transport ATP-binding protein AppF SW:APPF_BACSU (P42065) (329 aa) fasta scores: E(): 3e-61, 57.994% id in 319 aa, and to Bacillus halodurans oligopeptide ABC transporter BH3645 TR:Q9K6T1 (EMBL:AP001519) (322 aa) fasta scores: E(): 4.6e-57, 54.777% id in 314 aa. SAR0952, 54.198% identity (55.686% ungapped) in 262 aa overlap; oligopeptide transport ATP-binding protein 1002624 appF 2860993 appF Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transport ATP-binding protein YP_040378.1 1001644 D 282458 CDS YP_040379.1 49483155 2860991 1003279..1004160 1 NC_002952.2 Similar to Bacillus subtilis oligopeptide ABC transporter permease AppC SW:APPC_BACSU (P42063) (303 aa) fasta scores: E(): 1.7e-42, 44.218% id in 294 aa, and to Pasteurella multocida hypothetical protein PM1908 TR:Q9CJT3 (EMBL:AE006228) (303 aa) fasta scores: E(): 8.6e-38, 38.014% id in 292 aa; oligopeptide ABC transporter permease 1004160 appC 2860991 appC Staphylococcus aureus subsp. aureus MRSA252 oligopeptide ABC transporter permease YP_040379.1 1003279 D 282458 CDS YP_040380.1 49483156 2859433 complement(1004249..1005037) 1 NC_002952.2 Similar to the C-terminal region of Enterococcus faecium transposase TR:Q47815 (EMBL:L40841) (310 aa) fasta scores: E(): 1.9e-39, 46.183% id in 262 aa, and to the full length Neisseria gonorrhoeae hypothetical protein TR:Q50996 (EMBL:L36381) (267 aa) fasta scores: E(): 1.1e-27, 39.689% id in 257 aa; transposase 1005037 2859433 SAR0961 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040380.1 1004249 R 282458 CDS YP_040381.1 49483157 2859434 complement(1005258..1005815) 1 NC_002952.2 Similar to the C-terminal regions of Mycoplasma mycoides insertion element IS1296 hypothetical protein SW:YI6A_MYCMY (Q50239) (180 aa) fasta scores: E(): 0.0016, 26.812% id in 138 aa, and Bacillus thuringiensis hypothetical protein TR:P94596 (EMBL:Y09946) (185 aa) fasta scores: E(): 0.011, 32.075% id in 106 aa; insertion element protein 1005815 2859434 SAR0962 Staphylococcus aureus subsp. aureus MRSA252 insertion element protein YP_040381.1 1005258 R 282458 CDS YP_040382.1 49483158 2859435 1006111..1007757 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 1.5e-195, 97.993% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 2.5e-97, 51.346% id in 520 aa; transposase 1007757 2859435 SAR0963 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040382.1 1006111 D 282458 CDS YP_040383.1 49483159 2860404 complement(1007784..1008773) 1 NC_002952.2 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1008773 trpS 2860404 trpS Staphylococcus aureus subsp. aureus MRSA252 tryptophanyl-tRNA synthetase YP_040383.1 1007784 R 282458 CDS YP_040384.1 49483160 2859436 1009068..1009463 1 NC_002952.2 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; Spx family transcriptional regulator 1009463 spxA 2859436 spxA Staphylococcus aureus subsp. aureus MRSA252 Spx family transcriptional regulator YP_040384.1 1009068 D 282458 CDS YP_040385.1 49483161 2859437 1009834..1010553 1 NC_002952.2 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 1010553 2859437 SAR0966 Staphylococcus aureus subsp. aureus MRSA252 adaptor protein YP_040385.1 1009834 D 282458 CDS YP_040386.1 49483162 2859438 1010674..1011660 1 NC_002952.2 N-terminus is similar to the N-terminal regions of Lactococcus lactis transcription factor TR:P94875 (EMBL:X99710) (327 aa) fasta scores: E(): 1.1e-10, 29.675% id in 246 aa, and Streptococcus pyogenes transcription factor SPY1395 TR:Q99Z52 (EMBL:AE006576) (320 aa) fasta scores: E(): 9.6e-09, 27.876% id in 226 aa; hypothetical protein 1011660 2859438 SAR0967 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040386.1 1010674 D 282458 CDS YP_040387.1 49483163 2859894 1011708..1013516 1 NC_002952.2 Similar to Streptococcus agalactiae group B oligopeptidase PepB SW:PEPB_STRAG (Q53778) (601 aa) fasta scores: E(): 1.9e-93, 44.974% id in 587 aa, and to Bacillus licheniformis Pz-peptidase TR:P70922 (EMBL:D88209) (628 aa) fasta scores: E(): 1.7e-126, 56.314% id in 586 aa; oligopeptidase 1013516 pepB 2859894 pepB Staphylococcus aureus subsp. aureus MRSA252 oligopeptidase YP_040387.1 1011708 D 282458 CDS YP_040388.1 49483164 2859439 complement(1013976..1014782) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2855 TR:Q9K8Z7 (EMBL:AP001516) (306 aa) fasta scores: E(): 4.4e-20, 32.103% id in 271 aa, and to Bacillus subtilis hypothetical protein YjbH TR:O31606 (EMBL:Z99110) (275 aa) fasta scores: E(): 9.7e-20, 33.206% id in 262 aa. Possible alternative translational start sites; hypothetical protein 1014782 2859439 SAR0969 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040388.1 1013976 R 282458 CDS YP_040389.1 49483165 2859440 complement(1014805..1015170) 1 NC_002952.2 Similar to Tetrahymena pyriformis myoglobin SW:GLB_TETPY (P17724) (121 aa) fasta scores: E(): 0.00028, 31.373% id in 102 aa, and to Bacillus subtilis hypothetical protein YjbI TR:O31607 (EMBL:Z99110) (132 aa) fasta scores: E(): 3e-23, 53.448% id in 116 aa; hypothetical protein 1015170 2859440 SAR0970 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040389.1 1014805 R 282458 CDS YP_040390.1 49483166 2859441 complement(1015274..1015867) 1 NC_002952.2 Weakly similar to Oryctolagus cuniculus (rabbit) glutathione S-transferase SW:GTC_RABIT (Q08862) (220 aa) fasta scores: E(): 8.5, 27.381% id in 168 aa. Similar to Lactococcus lactis hypothetical protein YdgF TR:Q9CIJ7 (EMBL:AE006273) (197 aa) fasta scores: E(): 2e-16, 37.500% id in 192 aa; hypothetical protein 1015867 2859441 SAR0971 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040390.1 1015274 R 282458 CDS YP_040391.1 49483167 2859442 1016053..1016400 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2850 TR:Q9K902 (EMBL:AP001516) (126 aa) fasta scores: E(): 1.1e-09, 36.134% id in 119 aa, and to Bacillus subtilis hypothetical protein YjbL TR:O31610 (EMBL:Z99110) (122 aa) fasta scores: E(): 1.4e-09, 36.441% id in 118 aa; hypothetical protein 1016400 2859442 SAR0972 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040391.1 1016053 D 282458 CDS YP_040392.1 49483168 2859443 1016417..1017052 1 NC_002952.2 Similar to an internal region of Vibrio sp GTP pyrophosphokinase RelA SW:RELA_VIBSS (P55133) (744 aa) fasta scores: E(): 0.0063, 27.545% id in 167 aa, and to full length Bacillus halodurans GTP pyrophosphokinase BH2849 TR:Q9K903 (EMBL:AP001516) (211 aa) fasta scores: E(): 2.2e-49, 62.621% id in 206 aa; GTP pyrophosphokinase 1017052 2859443 SAR0973 Staphylococcus aureus subsp. aureus MRSA252 GTP pyrophosphokinase YP_040392.1 1016417 D 282458 CDS YP_040393.1 49483169 2859444 1017069..1017878 1 NC_002952.2 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1017878 ppnK 2859444 ppnK Staphylococcus aureus subsp. aureus MRSA252 inorganic polyphosphate/ATP-NAD kinase YP_040393.1 1017069 D 282458 CDS YP_040394.1 49483170 2859445 1017875..1018729 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YjbO SW:YJBO_BACSU (O31613) (283 aa) fasta scores: E(): 6e-32, 36.525% id in 282 aa, and to Bacillus halodurans hypothetical protein BH2847 TR:Q9K905 (EMBL:AP001516) (302 aa) fasta scores: E(): 1.1e-30, 35.836% id in 293 aa; RNA pseudouridylate synthase 1018729 2859445 SAR0975 Staphylococcus aureus subsp. aureus MRSA252 RNA pseudouridylate synthase YP_040394.1 1017875 D 282458 CDS YP_040395.1 49483171 2859446 1018750..1020135 1 NC_002952.2 Similar to Bacillus halodurans magnesium transporter BH0511 TR:Q9KFG8 (EMBL:AP001508) (452 aa) fasta scores: E(): 9.9e-61, 39.367% id in 442 aa, and to Bacillus subtilis hypothetical protein YkoK TR:O34442 (EMBL:AJ002571) (451 aa) fasta scores: E(): 1.6e-57, 38.462% id in 455 aa; divalent cation transport protein 1020135 2859446 SAR0976 Staphylococcus aureus subsp. aureus MRSA252 divalent cation transport protein YP_040395.1 1018750 D 282458 CDS YP_040396.1 49483172 2859447 1020145..1021989 1 NC_002952.2 N-terminal region is similar to Enterococcus hirae Na+/H+ antiporter protein NapA SW:NAPA_ENTHR (P26235) (383 aa) fasta scores: E(): 3.8e-10, 26.368% id in 402 aa. Full length CDS is similar to and to Bacillus subtilis hypothetical protein YjbQ TR:O31615 (EMBL:Z99110) (614 aa) fasta scores: E(): 2.9e-108, 52.545% id in 609 aa; cation transport protein 1021989 2859447 SAR0977 Staphylococcus aureus subsp. aureus MRSA252 cation transport protein YP_040396.1 1020145 D 282458 CDS YP_040397.1 49483173 2859621 1022267..1023037 1 NC_002952.2 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 1023037 fabI 2859621 fabI Staphylococcus aureus subsp. aureus MRSA252 enoyl-ACP reductase YP_040397.1 1022267 D 282458 CDS YP_040398.1 49483174 2859448 complement(1023233..1024318) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2921 TR:Q9K8T1 (EMBL:AP001517) (361 aa) fasta scores: E(): 4.4e-33, 34.795% id in 365 aa, and to Bacillus subtilis hypothetical protein YueF SW:YUEF_BACSU (O32095) (369 aa) fasta scores: E(): 5.1e-33, 35.556% id in 360 aa; hypothetical protein 1024318 2859448 SAR0979 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040398.1 1023233 R 282458 CDS YP_040399.1 49483175 2859449 1024660..1026228 1 NC_002952.2 Similar to thermophilic Bacillus sp PS3 sodium/proton-dependent alanine carrier protein Acp SW:ALCP_BACP3 (P30145) (445 aa) fasta scores: E(): 3.9e-51, 48.017% id in 479 aa, and to Bacillus subtilis hypothetical protein YrbD TR:O32060 (EMBL:Z99118) (484 aa) fasta scores: E(): 1.8e-70, 54.617% id in 509 aa. Possible alternative translational start site; sodium:alanine symporter family protein 1026228 2859449 SAR0980 Staphylococcus aureus subsp. aureus MRSA252 sodium:alanine symporter family protein YP_040399.1 1024660 D 282458 CDS YP_040400.1 49483176 2859450 1026371..1027129 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1440 TR:Q9KCX9 (EMBL:AP001512) (242 aa) fasta scores: E(): 2e-35, 41.975% id in 243 aa, and to Bacillus subtilis hypothetical protein YjcH TR:O31630 (EMBL:Z99110) (240 aa) fasta scores: E(): 5.8e-35, 39.316% id in 234 aa; hypothetical protein 1027129 2859450 SAR0981 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040400.1 1026371 D 282458 CDS YP_040401.1 49483177 2859451 1027295..1028020 1 NC_002952.2 Poor database matches. Similar an internal region of Lactococcus lactis restriction-modification system protein AbiM TR:P71445 (EMBL:X97263) (580 aa) fasta scores: E(): 4, 24.255% id in 235 aa; hypothetical protein 1028020 2859451 SAR0982 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040401.1 1027295 D 282458 CDS YP_040402.1 49483178 2859452 1028022..1028873 1 NC_002952.2 Poor database matches. Similar to Bacillus cereus DNA alkylation repair enzyme Alk1 TR:Q9XBJ4 (EMBL:AJ010139) (287 aa) fasta scores: E(): 0.00011, 22.868% id in 258 aa; hypothetical protein 1028873 2859452 SAR0983 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040402.1 1028022 D 282458 CDS YP_040403.1 49483179 2859454 1029615..1030124 1 NC_002952.2 similar to 2'-5' RNA ligase; hypothetical protein 1030124 2859454 SAR0985 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040403.1 1029615 D 282458 CDS YP_040404.1 49483180 2861139 complement(1030237..1031427) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2311 TR:Q9KAH6 (EMBL:AP001515) (391 aa) fasta scores: E(): 1.4e-08, 25.000% id in 400 aa, and to Escherichia coli hypothetical protein YceE SW:YCEE_ECOLI (P25744) (408 aa) fasta scores: E(): 1.1e-07, 24.422% id in 389 aa; hypothetical protein 1031427 2861139 SAR0986 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040404.1 1030237 R 282458 CDS YP_040405.1 49483181 2861140 complement(1031405..1032580) 1 NC_002952.2 processive; catalyzes the formation of mono-, di- and tri-glucosyldiacylglycerol by the progressive transfer of glucosyl residues to diacylglycerol; involved in the formation of membrane glycolipids; diacylglycerol glucosyltransferase 1032580 2861140 SAR0987 Staphylococcus aureus subsp. aureus MRSA252 diacylglycerol glucosyltransferase YP_040405.1 1031405 R 282458 CDS YP_040406.1 49483182 2861323 1033012..1034496 1 NC_002952.2 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1034496 murE 2861323 murE Staphylococcus aureus subsp. aureus MRSA252 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase YP_040406.1 1033012 D 282458 CDS YP_040407.1 49483183 2861141 1034486..1034737 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YueH TR:O32093 (EMBL:Z99120) (82 aa) fasta scores: E(): 1.5, 26.866% id in 67 aa; hypothetical protein 1034737 2861141 SAR0989 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040407.1 1034486 D 282458 CDS YP_040408.1 49483184 2860150 1034737..1036299 1 NC_002952.2 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 1036299 prfC 2860150 prfC Staphylococcus aureus subsp. aureus MRSA252 peptide chain release factor 3 YP_040408.1 1034737 D 282458 CDS YP_040409.1 49483185 2861142 1036601..1037404 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2553 TR:Q9K9U2 (EMBL:AP001515) (265 aa) fasta scores: E(): 2.4e-48, 53.640% id in 261 aa, and to Bacillus megaterium hypothetical protein YkoY TR:Q9ZF98 (EMBL:AF109909) (271 aa) fasta scores: E(): 5.2e-31, 57.414% id in 263 aa; hypothetical protein 1037404 2861142 SAR0991 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040409.1 1036601 D 282458 CDS YP_040410.1 49483186 2861143 1037638..1039947 1 NC_002952.2 C-terminus is similar to Bacillus subtilis hypothetical protease YyxA SW:YYXA_BACSU (P39668) (400 aa) fasta scores: E(): 1.2e-29, 34.332% id in 367 aa, and to Streptococcus pneumoniae serine protease TR:O06670 (EMBL:AF000658) (397 aa) fasta scores: E(): 5.6e-27, 35.143% id in 350 aa; protease 1039947 2861143 SAR0992 Staphylococcus aureus subsp. aureus MRSA252 protease YP_040410.1 1037638 D 282458 CDS YP_040411.1 49483187 2861144 1039964..1041322 1 NC_002952.2 Similar to Enterococcus hirae vacuolar-type sodium ATP synthase subunit J NtpJ SW:NTPJ_ENTHR (P43440) (451 aa) fasta scores: E(): 1.4e-40, 31.858% id in 452 aa, and to Bacillus subtilis hypothetical protein YkrM TR:O31658 (EMBL:Z99111) (449 aa) fasta scores: E(): 2.3e-83, 50.222% id in 450 aa; sodium transport protein 1041322 2861144 SAR0993 Staphylococcus aureus subsp. aureus MRSA252 sodium transport protein YP_040411.1 1039964 D 282458 CDS YP_040412.1 49483188 2861145 1041458..1042972 1 NC_002952.2 Poor database matches. Similar to Lactococcus lactis phosphatase YcjM TR:Q9CIQ3 (EMBL:AE006267) (519 aa) fasta scores: E(): 8.6e-16, 22.960% id in 527 aa, and to Helicobacter pylori 2',3'-cyclic-nucleotide 2'-phosphodiesterase HP0104 TR:O24930 (EMBL:AE000532) (581 aa) fasta scores: E(): 7.6e-14, 22.701% id in 511 aa; 5'-nucleotidase 1042972 2861145 SAR0994 Staphylococcus aureus subsp. aureus MRSA252 5'-nucleotidase YP_040412.1 1041458 D 282458 CDS YP_040413.1 49483189 2861146 complement(1043461..1044030) 1 NC_002952.2 Similar to Bacillus subtilis competence transcription factor ComK SW:COMK_BACSU (P40396) (192 aa) fasta scores: E(): 5.4e-10, 29.487% id in 156 aa, and to Listeria monocytogenes competence transcription factor ComK TR:Q9RP24 (EMBL:AF174588) (190 aa) fasta scores: E(): 1.8e-09, 27.439% id in 164 aa; regulatory protein 1044030 2861146 SAR0995 Staphylococcus aureus subsp. aureus MRSA252 regulatory protein YP_040413.1 1043461 R 282458 CDS YP_040414.1 49483190 2861147 1044231..1044458 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YhzC TR:O31594 (EMBL:Z99109) (77 aa) fasta scores: E(): 1.3, 32.836% id in 67 aa; hypothetical protein 1044458 2861147 SAR0996 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040414.1 1044231 D 282458 CDS YP_040415.1 49483191 2861148 complement(1044539..1045525) 1 NC_002952.2 Similar to Escherichia coli lipoate-protein ligase A LplA SW:LPLA_ECOLI (P32099) (337 aa) fasta scores: E(): 3.4e-30, 34.323% id in 303 aa, and to Bacillus subtilis hypothetical protein YhfJ TR:O07608 (EMBL:Y14083) (331 aa) fasta scores: E(): 4.8e-70, 56.970% id in 330 aa; lipoate-protein ligase A 1045525 2861148 SAR0997 Staphylococcus aureus subsp. aureus MRSA252 lipoate-protein ligase A YP_040415.1 1044539 R 282458 CDS YP_040416.1 49483192 2861149 1045724..1045900 1 NC_002952.2 Poor database matches. Similar to C-terminal region of Bacillus subtilis hypothetical protein YkvS TR:O31684 (EMBL:Z99111) (143 aa) fasta scores: E(): 1.6e-11, 61.818% id in 55 aa. Possible gene remnant; hypothetical protein 1045900 2861149 SAR0998 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040416.1 1045724 D 282458 CDS YP_040417.1 49483193 2861150 1045915..1046517 1 NC_002952.2 Poor database matches. Similar to Thermotoga maritima hypothetical protein TT1529 TR:Q9X1L5 (EMBL:AE001800) (208 aa) fasta scores: E(): 0.018, 23.858% id in 197 aa; hypothetical protein 1046517 2861150 SAR0999 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040417.1 1045915 D 282458 CDS YP_040418.1 49483194 2861151 1046697..1046876 1 NC_002952.2 Poor database matches. Similar to Centruroides noxius toxin Cn10 precursor CngTIX TR:Q94435 (EMBL:Y08270) (81 aa) fasta scores: E(): 3.2, 34.043% id in 47 aa. Doubtful CDS; hypothetical protein 1046876 2861151 SAR1000 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040418.1 1046697 D 282458 CDS YP_040419.1 49483195 2859062 <1047536..1047817 1 NC_002952.2 Poor database matches. Similar to Lactococcus lactis lactococcin 972 precursor LclA TR:O86283 (EMBL:AJ002203) (91 aa) fasta scores: E(): 0.003, 34.884% id in 86 aa; hypothetical protein 1047817 2859062 SAR1001 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040419.1 <1047536 D 282458 CDS YP_040420.1 49483196 2861559 1047861..1049825 1 NC_002952.2 Poor database matches. Similar to Lactococcus lactis hypothetical protein YujE TR:Q9CE29 (EMBL:AE006431) (660 aa) fasta scores: E(): 3.8e-11, 19.062% id in 661 aa; hypothetical protein 1049825 2861559 SAR1002 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040420.1 1047861 D 282458 CDS YP_040421.1 49483197 2861560 1049828..1050148 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YxeA SW:YXEA_BACSU (P54940) (115 aa) fasta scores: E(): 0.0055, 28.448% id in 116 aa; hypothetical protein 1050148 2861560 SAR1003 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040421.1 1049828 D 282458 CDS YP_040422.1 49483198 2861561 1050145..1050786 1 NC_002952.2 Similar to Streptococcus pneumoniae hypothetical protein TR:Q9ZHB1 (EMBL:AF068902) (213 aa) fasta scores: E(): 1.6e-25, 47.317% id in 205 aa, and to Lactococcus lactis hypothetical ATP binding protein TR:Q9L650 (EMBL:AF242367) (207 aa) fasta scores: E(): 7e-24, 42.995% id in 207 aa; ABC transporter ATP-binding protein 1050786 2861561 SAR1004 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040422.1 1050145 D 282458 CDS YP_040423.1 49483199 2861562 complement(1050874..1051164) 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Campylobacter jejuni flagellar biosynthesis protein CJ0882 TR:Q9PP48 (EMBL:AL139076) (724 aa) fasta scores: E(): 9.7, 28.395% id in 81 aa. Doubtful CDS; hypothetical protein 1051164 2861562 SAR1005 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040423.1 1050874 R 282458 CDS YP_040424.1 49483200 2861563 1051201..1051308 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 1051308 2861563 SAR1006 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040424.1 1051201 D 282458 CDS YP_040425.1 49483201 2861564 1051505..1051792 1 NC_002952.2 hypothetical protein 1051792 2861564 SAR1007 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040425.1 1051505 D 282458 CDS YP_040426.1 49483202 2861566 complement(1053367..1053723) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3304 TR:Q9RC47 (EMBL:AB024562) (129 aa) fasta scores: E(): 1.1e-10, 36.893% id in 103 aa, and to Bacillus subtilis hypothetical protein YfiD SW:YFID_BACSU (P54720) (134 aa) fasta scores: E(): 1.5e-08, 33.333% id in 102 aa; hypothetical protein 1053723 2861566 SAR1010 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040426.1 1053367 R 282458 CDS YP_040427.1 49483203 2861567 1054214..1055173 1 NC_002952.2 Similar to Escherichia coli citrate-dependent iron transport, periplasmic protein FecB SW:FECB_ECOLI (P15028) (300 aa) fasta scores: E(): 2e-22, 38.652% id in 282 aa, and to Bacillus subtilis hypothetical protein YfmC TR:O34348 (EMBL:Z99108) (315 aa) fasta scores: E(): 3.3e-24, 38.390% id in 323 aa; transport system extracellular binding lipoprotein 1055173 2861567 SAR1011 Staphylococcus aureus subsp. aureus MRSA252 transport system extracellular binding lipoprotein YP_040427.1 1054214 D 282458 CDS YP_040428.1 49483204 2861568 complement(1055220..1055336) 1 NC_002952.2 hypothetical protein 1055336 2861568 SAR1012 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040428.1 1055220 R 282458 CDS YP_040429.1 49483205 2861569 complement(1055415..1055630) 1 NC_002952.2 Poor database matches. Similar to Lactococcus lactis hypothetical protein YafF TR:Q9CJE6 (EMBL:AE006243) (80 aa) fasta scores: E(): 0.031, 32.812% id in 64 aa. C-terminus is similar to the C-terminal region of SAR1190, 58.209% identity (59.091% ungapped) in 67 aa overlap; hypothetical protein 1055630 2861569 SAR1013 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040429.1 1055415 R 282458 CDS YP_040430.1 49483206 2861570 1055795..1056346 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans hypothetical protein BH2104 TR:Q9KB31 (EMBL:AP001514) (203 aa) fasta scores: E(): 0.005, 26.087% id in 184 aa, and to Deinococcus radiodurans hypothetical protein DR0797 TR:Q9RW72 (EMBL:AE001934) (158 aa) fasta scores: E(): 0.00012, 28.358% id in 134 aa; hypothetical protein 1056346 2861570 SAR1014 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040430.1 1055795 D 282458 CDS YP_040431.1 49483207 2861571 complement(1056398..1057336) 1 NC_002952.2 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 1057336 2861571 SAR1015 Staphylococcus aureus subsp. aureus MRSA252 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_040431.1 1056398 R 282458 CDS YP_040432.1 49483208 2861572 1057509..1058879 1 NC_002952.2 C-terminus is similar to the C-terminal regions of Escherichia coli isochorismate synthase EntC SW:ENTC_ECOLI (P10377) (391 aa) fasta scores: E(): 2.7e-18, 29.391% id in 279 aa, and Bacillus subtilis menaquinone-specific isochorismate synthase MenF SW:MENF_BACSU (P23973) (471 aa) fasta scores: E(): 5.4e-38, 34.562% id in 434 aa. Possible alternative translational start site; chorismate binding protein 1058879 2861572 SAR1016 Staphylococcus aureus subsp. aureus MRSA252 chorismate binding protein YP_040432.1 1057509 D 282458 CDS YP_040433.1 49483209 2861573 1058866..1060539 1 NC_002952.2 Similar to Escherichia coli menaquinone biosynthesis bifunctional protein [includes: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase and alpha-ketoglutarate decarboxylase] MenD SW:MEND_ECOLI (P17109) (556 aa) fasta scores: E(): 4.5e-38, 29.107% id in 560 aa, and to Bacillus subtilis menaquinone biosynthesis bifunctional protein [includes: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase and alpha-ketoglutarate decarboxylase] MenD SW:MEND_BACSU (P23970) (580 aa) fasta scores: E(): 7.8e-34, 39.478% id in 575 aa; menaquinone biosynthesis bifunctional protein 1060539 2861573 SAR1017 Staphylococcus aureus subsp. aureus MRSA252 menaquinone biosynthesis bifunctional protein YP_040433.1 1058866 D 282458 CDS YP_040434.1 49483210 2861574 1060526..1061329 1 NC_002952.2 Similar to Rhodococcus sp 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BpdF TR:Q52897 (EMBL:U44891) (297 aa) fasta scores: E(): 2.5e-08, 25.806% id in 279 aa, and to Bacillus subtilis hypothetical protein YtxM TR:O34312 (EMBL:AF008220) (274 aa) fasta scores: E(): 1.9e-27, 34.749% id in 259 aa. CDS is truncated at the N-terminus in comparison to the Rhodococcus sp protein; hydrolase 1061329 2861574 SAR1018 Staphylococcus aureus subsp. aureus MRSA252 hydrolase YP_040434.1 1060526 D 282458 CDS YP_040435.1 49483211 2861160 1061322..1062143 1 NC_002952.2 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 1062143 menB 2861160 menB Staphylococcus aureus subsp. aureus MRSA252 naphthoate synthase YP_040435.1 1061322 D 282458 CDS YP_040436.1 49483212 2859508 complement(1062379..1062708) 1 NC_002952.2 Similar to an internal region of Clostridium botulinum main hemagglutinin component HA-33 SW:HA33_CLOBO (P46084) (285 aa) fasta scores: E(): 2.3, 25.743% id in 101 aa. Previously sequenced as Staphylococcus aureus serine protease (ssp) operon hypothetical protein SspC TR:Q9EYW6 (EMBL:AF309515) (109 aa) fasta scores: E(): 2.8e-44, 99.083% id in 109 aa; hypothetical protein 1062708 sspC 2859508 sspC Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040436.1 1062379 R 282458 CDS YP_040437.1 49483213 2859507 complement(1062746..1063927) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus cysteine protease preproprotein SspB TR:Q9EYW7 (EMBL:AF309515) (393 aa) fasta scores: E(): 6.4e-137, 97.710% id in 393 aa; cysteine protease precursor 1063927 sspB 2859507 sspB Staphylococcus aureus subsp. aureus MRSA252 cysteine protease precursor YP_040437.1 1062746 R 282458 CDS YP_040438.1 49483214 2859506 complement(1064009..1065082) 1 NC_002952.2 Almost identical to Staphylococcus aureus glutamyl endopeptidase precursor TR:Q04186 (EMBL:D00730) (357 aa) fasta scores: E(): 5e-126, 99.440% id in 357 aa. Highly similar to Staphylococcus aureus serine protease (ssp) operon V8 protease SspA TR:AAG45843 (EMBL:AF309515) (336 aa) fasta scores: E(): 1.2e-110, 91.317% id in 357 aa. CDS contains a C-terminus repeat region (D/NNP x19), residues 287 to 343. CDS contains extra residues (21) in this repeat region relative to the SspA V8 protease. N-terminus is similar to Staphylococcus warneri glutamyl endopeptidase ProM TR:Q9FBG1 (EMBL:AJ293885) (316 aa) fasta scores: E(): 2.8e-75, 71.069% id in 318 aa; glutamyl endopeptidase precursor 1065082 sspA 2859506 sspA Staphylococcus aureus subsp. aureus MRSA252 glutamyl endopeptidase precursor YP_040438.1 1064009 R 282458 CDS YP_040439.1 49483215 2861575 complement(1065610..1066764) 1 NC_002952.2 Similar to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) (393 aa) fasta scores: E(): 1.8e-40, 35.967% id in 367 aa, and to Bacillus subtilis aminotransferase A PatA SW:PATA_BACSU (P16524) (392 aa) fasta scores: E(): 3.5e-62, 45.195% id in 385 aa; aminotransferase 1066764 2861575 SAR1023 Staphylococcus aureus subsp. aureus MRSA252 aminotransferase YP_040439.1 1065610 R 282458 CDS YP_040440.1 49483216 2861577 1068123..1068542 1 NC_002952.2 Similar to Escherichia coli transcriptional regulator SlyA SW:SLYA_ECOLI (P55740) (146 aa) fasta scores: E(): 0.058, 31.724% id in 145 aa, and to Staphylococcus epidermidis transcriptional regulator AtlR TR:O33636 (EMBL:U71377) (139 aa) fasta scores: E(): 2.6e-41, 87.591% id in 137 aa; MarR family regulatory protein 1068542 2861577 SAR1025 Staphylococcus aureus subsp. aureus MRSA252 MarR family regulatory protein YP_040440.1 1068123 D 282458 CDS YP_040441.1 49483217 2859873 complement(1068750..1072523) 1 NC_002952.2 Highly similar to Staphylococcus aureus bifunctional autolysin precursor [includes: N-acetylmuramoyl-L-alanine amidase and endo-beta-N-acetylglucosaminidase] Atl SW:ATL_STAAU (P52081) (1256 aa) fasta scores: E(): 0, 97.538% id in 1259 aa. Similar to Staphylococcus epidermidis autolysin AtlE TR:O33635 (EMBL:U71377) (1335 aa) fasta scores: E(): 5.7e-102, 59.808% id in 1356 aa; bifunctional autolysin precursor 1072523 atl 2859873 atl Staphylococcus aureus subsp. aureus MRSA252 bifunctional autolysin precursor YP_040441.1 1068750 R 282458 CDS YP_040442.1 49483218 2861578 complement(1072751..1073185) 1 NC_002952.2 Similar to Staphylococcus epidermidis hypothetical protein TR:O33634 (EMBL:U71377) (140 aa) fasta scores: E(): 3.2e-25, 55.000% id in 140 aa, and to Bacillus halodurans hypothetical protein BH1438 TR:Q9KCY1 (EMBL:AP001512) (144 aa) fasta scores: E(): 8.8e-21, 46.667% id in 135 aa; acetyltransferase (GNAT) family protein 1073185 2861578 SAR1027 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_040442.1 1072751 R 282458 CDS YP_040443.1 49483219 2861579 complement(1073341..1073811) 1 NC_002952.2 Poor database matches. Similar to Staphylococcus epidermidis autolysin hypothetical protein TR:O33633 (EMBL:U71377) (156 aa) fasta scores: E(): 4e-57, 87.179% id in 156 aa; hypothetical protein 1073811 2861579 SAR1028 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040443.1 1073341 R 282458 CDS YP_040444.1 49483220 2860777 complement(1073859..1075085) 1 NC_002952.2 N-terminal region is similar to Bacillus subtilis membrane-bound attenuator of the expression of both lytABC and lytR operons, LytR SW:LYTR_BACSU (Q02115) (306 aa) fasta scores: E(): 3.3e-22, 32.484% id in 314 aa, and to Bacillus halodurans transcriptional regulator BH3647 TR:Q9K6S9 (EMBL:AP001519) (359 aa) fasta scores: E(): 4e-32, 37.730% id in 326 aa; hypothetical protein 1075085 2860777 SAR1029 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040444.1 1073859 R 282458 CDS YP_040445.1 49483221 2860671 1075526..1076719 1 NC_002952.2 Similar to Staphylococcus aureus autolysis and methicillin resistant-related protein Fmt TR:O50608 (EMBL:AB009635) (397 aa) fasta scores: E(): 5.6e-140, 93.451% id in 397 aa, and to Bacillus subtilis penicillin-binding protein PbpX TR:O31773 (EMBL:Z99112) (391 aa) fasta scores: E(): 8.6e-25, 29.381% id in 388 aa; autolysis and methicillin resistant-related protein 1076719 fmt 2860671 fmt Staphylococcus aureus subsp. aureus MRSA252 autolysis and methicillin resistant-related protein YP_040445.1 1075526 D 282458 CDS YP_040446.1 49483222 2859295 complement(1077062..1077352) 1 NC_002952.2 Similar to Bacillus subtilis quinol oxidase polypeptide IV QoxD SW:QOX4_BACSU (P34959) (123 aa) fasta scores: E(): 8.2e-15, 52.688% id in 93 aa, and to Bacillus halodurans cytochrome aa3 quinol oxidase subunit IV BH2067 TR:Q9KB64 (EMBL:AP001514) (136 aa) fasta scores: E(): 2.8e-11, 47.674% id in 86 aa; quinol oxidase polypeptide IV 1077352 qoxD 2859295 qoxD Staphylococcus aureus subsp. aureus MRSA252 quinol oxidase polypeptide IV YP_040446.1 1077062 R 282458 CDS YP_040447.1 49483223 2859294 complement(1077349..1077954) 1 NC_002952.2 Similar to Bacillus subtilis quinol oxidase polypeptide III QoxC SW:QOX3_BACSU (P34958) (204 aa) fasta scores: E(): 1.3e-38, 54.211% id in 190 aa, and to Bacillus halodurans cytochrome aa3 quinol oxidase subunit III BH2066 TR:Q9KB65 (EMBL:AP001514) (204 aa) fasta scores: E(): 3e-39, 56.316% id in 190 aa; quinol oxidase polypeptide III 1077954 qoxC 2859294 qoxC Staphylococcus aureus subsp. aureus MRSA252 quinol oxidase polypeptide III YP_040447.1 1077349 R 282458 CDS YP_040448.1 49483224 2859293 complement(1077944..1079932) 1 NC_002952.2 Similar to Bacillus subtilis quinol oxidase polypeptide I QoxB SW:QOX1_BACSU (P34956) (649 aa) fasta scores: E(): 1.7e-163, 62.154% id in 650 aa, and to Bacillus halodurans cytochrome aa3 quinol oxidase subunit I BH2065 TR:Q9KB66 (EMBL:AP001514) (647 aa) fasta scores: E(): 5.2e-160, 63.060% id in 647 aa; quinol oxidase polypeptide I 1079932 qoxB 2859293 qoxB Staphylococcus aureus subsp. aureus MRSA252 quinol oxidase polypeptide I YP_040448.1 1077944 R 282458 CDS YP_040449.1 49483225 2859292 complement(1079932..1081032) 1 NC_002952.2 Similar to Bacillus subtilis quinol oxidase polypeptide II precursor QoxA SW:QOX2_BACSU (P34957) (322 aa) fasta scores: E(): 1.5e-47, 45.333% id in 300 aa, and to Bacillus halodurans cytochrome aa3 quinol oxidase subunit II BH2064 TR:Q9RC66 (EMBL:AB024557) (329 aa) fasta scores: E(): 5.5e-35, 38.871% id in 319 aa. CDS is extended at the C-terminus in comparison to Bacillus subtilis and Bacillus halodurans othologues; quinol oxidase polypeptide II precursor 1081032 qoxA 2859292 qoxA Staphylococcus aureus subsp. aureus MRSA252 quinol oxidase polypeptide II precursor YP_040449.1 1079932 R 282458 CDS YP_040450.1 49483226 2860778 complement(1081604..1081921) 1 NC_002952.2 hypothetical protein 1081921 2860778 SAR1035 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040450.1 1081604 R 282458 CDS YP_040451.1 49483227 2860677 complement(1082761..1083621) 1 NC_002952.2 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 1083621 folD 2860677 folD Staphylococcus aureus subsp. aureus MRSA252 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_040451.1 1082761 R 282458 CDS YP_040452.1 49483228 2859545 1083822..1084304 1 NC_002952.2 Similar to Bacillus subtilis phosphoribosylaminoimidazole carboxylase catalytic subunit PurE SW:PUR6_BACSU (P12044) (162 aa) fasta scores: E(): 6.1e-32, 60.510% id in 157 aa, and to Aquifex aeolicus phosphoribosylaminoimidazole carboxylase catalytic subunit PurE SW:PUR6_AQUAE (O67239) (167 aa) fasta scores: E(): 7.5e-31, 62.025% id in 158 aa; phosphoribosylaminoimidazole carboxylase catalytic subunit 1084304 purE 2859545 purE Staphylococcus aureus subsp. aureus MRSA252 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_040452.1 1083822 D 282458 CDS YP_040453.1 49483229 2859548 1084291..1085415 1 NC_002952.2 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1085415 purK 2859548 purK Staphylococcus aureus subsp. aureus MRSA252 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_040453.1 1084291 D 282458 CDS YP_040454.1 49483230 2860160 1085419..1086123 1 NC_002952.2 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 1086123 purC 2860160 purC Staphylococcus aureus subsp. aureus MRSA252 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_040454.1 1085419 D 282458 CDS YP_040455.1 49483231 2860779 1086123..1086386 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YexA SW:YEXA_BACSU (P12049) (84 aa) fasta scores: E(): 5.6e-09, 38.272% id in 81 aa, and to Bacillus halodurans hypothetical protein BH0627 TR:Q9KF59 (EMBL:AP001509) (84 aa) fasta scores: E(): 3.8e-08, 36.905% id in 84 aa; hypothetical protein 1086386 2860779 SAR1041 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040455.1 1086123 D 282458 CDS YP_040456.1 49483232 2859552 1086388..1087059 1 NC_002952.2 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 1087059 purQ 2859552 purQ Staphylococcus aureus subsp. aureus MRSA252 phosphoribosylformylglycinamidine synthase I YP_040456.1 1086388 D 282458 CDS YP_040457.1 49483233 2859549 1087052..1089241 1 NC_002952.2 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 1089241 purL 2859549 purL Staphylococcus aureus subsp. aureus MRSA252 phosphoribosylformylglycinamidine synthase II YP_040457.1 1087052 D 282458 CDS YP_040458.1 49483234 2859546 1089220..1090704 1 NC_002952.2 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1090704 purF 2859546 purF Staphylococcus aureus subsp. aureus MRSA252 amidophosphoribosyltransferase YP_040458.1 1089220 D 282458 CDS YP_040459.1 49483235 2859550 1090697..1091725 1 NC_002952.2 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 1091725 purM 2859550 purM Staphylococcus aureus subsp. aureus MRSA252 phosphoribosylaminoimidazole synthetase YP_040459.1 1090697 D 282458 CDS YP_040460.1 49483236 2859551 1091728..1092294 1 NC_002952.2 Similar to Bacillus subtilis phosphoribosylglycinamide formyltransferase PurN SW:PUR3_BACSU (P12040) (195 aa) fasta scores: E(): 1.5e-29, 49.735% id in 189 aa, and to Bacillus halodurans phosphoribosylglycinamide formyltransferase BH0632 TR:Q9KF54 (EMBL:AP001509) (188 aa) fasta scores: E(): 1.1e-29, 47.059% id in 187 aa; phosphoribosylglycinamide formyltransferase 1092294 purN 2859551 purN Staphylococcus aureus subsp. aureus MRSA252 phosphoribosylglycinamide formyltransferase YP_040460.1 1091728 D 282458 CDS YP_040461.1 49483237 2859547 1092309..1093787 1 NC_002952.2 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1093787 purH 2859547 purH Staphylococcus aureus subsp. aureus MRSA252 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_040461.1 1092309 D 282458 CDS YP_040462.1 49483238 2859544 1093809..1095056 1 NC_002952.2 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1095056 purD 2859544 purD Staphylococcus aureus subsp. aureus MRSA252 phosphoribosylamine--glycine ligase YP_040462.1 1093809 D 282458 CDS YP_040463.1 49483239 2860780 complement(1095324..1096145) 1 NC_002952.2 Similar to Lactobacillus helveticus proline iminopeptidase PepI TR:Q48561 (EMBL:Z56283) (217 aa) fasta scores: E(): 0.00045, 25.751% id in 233 aa, and to Bacillus subtilis hypothetical protein YkoC TR:O34572 (EMBL:AJ002571) (254 aa) fasta scores: E(): 4.5e-10, 24.336% id in 226 aa; cobalt transport protein 1096145 2860780 SAR1049 Staphylococcus aureus subsp. aureus MRSA252 cobalt transport protein YP_040463.1 1095324 R 282458 CDS YP_040464.1 49483240 2860781 complement(1096123..1097523) 1 NC_002952.2 Similar to Methanobacterium thermoautotrophicum methyl coenzyme M reductase system, component A2 homologue MTH454 TR:O26554 (EMBL:AE000829) (480 aa) fasta scores: E(): 3.7e-16, 27.696% id in 473 aa, and to Streptococcus pyogenes ABC transporter SPY1787 TR:Q99YA9 (EMBL:AE006606) (464 aa) fasta scores: E(): 2.9e-14, 25.747% id in 435 aa; ABC transporter ATP-binding protein 1097523 2860781 SAR1050 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040464.1 1096123 R 282458 CDS YP_040465.1 49483241 2860782 complement(1097538..1098113) 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YkoE TR:O34738 (EMBL:AJ002571) (199 aa) fasta scores: E(): 1.4e-13, 36.313% id in 179 aa; hypothetical protein 1098113 2860782 SAR1051 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040465.1 1097538 R 282458 CDS YP_040466.1 49483242 2860783 complement(1098697..1098831) 1 NC_002952.2 hypothetical protein 1098831 2860783 SAR1052 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040466.1 1098697 R 282458 CDS YP_040467.1 49483243 2860784 1098983..1100278 1 NC_002952.2 Poor database matches. N-terminal region is similar to Methanococcus jannaschii hypothetical protein MJ0923 SW:Y923_METJA (Q58333) (297 aa) fasta scores: E(): 3.4, 20.328% id in 305 aa, and C-terminal region is similar to Staphylococcus xylosus hypothetical protein fragment TR:Q9EYR2 (EMBL:AF316496) (199 aa) fasta scores: E(): 9.7e-46, 69.231% id in 195 aa; hypothetical protein 1100278 2860784 SAR1053 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040467.1 1098983 D 282458 CDS YP_040468.1 49483244 2860785 1100703..1101875 1 NC_002952.2 Similar to Staphylococcus xylosus hypothetical protein TR:Q9EYR1 (EMBL:AF316496) (389 aa) fasta scores: E(): 4.8e-114, 72.564% id in 390 aa, and to Bacillus subtilis hypothetical protein YwbD SW:YWBD_BACSU (P39587) (396 aa) fasta scores: E(): 6.1e-67, 48.346% id in 393 aa; hypothetical protein 1101875 2860785 SAR1054 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040468.1 1100703 D 282458 CDS YP_040469.1 49483245 2860786 1101929..1102471 1 NC_002952.2 Poor database matches. Similar to Staphylococcus xylosus hypothetical protein TR:Q9EYR0 (EMBL:AF316496) (180 aa) fasta scores: E(): 2e-48, 70.000% id in 180 aa; hypothetical protein 1102471 2860786 SAR1055 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040469.1 1101929 D 282458 CDS YP_040470.1 49483246 2860156 1102625..1102891 1 NC_002952.2 Previously sequenced as Staphylococcus aureus histidine-containing phosphocarrier protein (HPr) PtsH SW:PTHP_STAAU (P02907) (88 aa) fasta scores: E(): 8.1e-31, 100.000% id in 88 aa. Similar to Staphylococcus carnosus histidine-containing phosphocarrier protein PtsH SW:PTHP_STACA (P23534) (88 aa) fasta scores: E(): 3.5e-29, 94.318% id in 88 aa; phosphocarrier protein HPr 1102891 ptsH 2860156 ptsH Staphylococcus aureus subsp. aureus MRSA252 phosphocarrier protein HPr YP_040470.1 1102625 D 282458 CDS YP_040471.1 49483247 2860157 1102894..1104612 1 NC_002952.2 Similar to Staphylococcus carnosus phosphoenolpyruvate-protein phosphotransferase PtsI SW:PT1_STACA (P23533) (574 aa) fasta scores: E(): 4e-170, 80.628% id in 573 aa. Previously sequenced as Staphylococcus aureus phosphoenolpyruvate-protein phosphotransferase PtsI SW:PT1_STAAU (P51183) (572 aa) fasta scores: E(): 7.4e-207, 99.301% id in 572 aa; phosphoenolpyruvate-protein phosphotransferase 1104612 ptsI 2860157 ptsI Staphylococcus aureus subsp. aureus MRSA252 phosphoenolpyruvate-protein phosphotransferase YP_040471.1 1102894 D 282458 CDS YP_040472.1 49483248 2860787 complement(1104849..1105082) 1 NC_002952.2 Similar to Escherichia coli glutaredoxin 3 GrxC SW:GLR3_ECOLI (P37687) (82 aa) fasta scores: E(): 1.6, 28.788% id in 66 aa, and to Clostridium pasteurianum hypothetical glutaredoxin-like protein in rubredoxin operon SW:YRUB_CLOPA (P23171) (75 aa) fasta scores: E(): 0.018, 31.944% id in 72 aa; glutaredoxin 1105082 2860787 SAR1058 Staphylococcus aureus subsp. aureus MRSA252 glutaredoxin YP_040472.1 1104849 R 282458 CDS YP_040473.1 49483249 2860788 1105280..1106641 1 NC_002952.2 Similar to Rhodobacter sphaeroides quinol oxidase subunit I QxtA TR:O86080 (EMBL:AF084032) (465 aa) fasta scores: E(): 6.9e-42, 32.237% id in 456 aa, and to Bacillus stearothermophilus cytochrome bd-type quinol oxidase subunit I CbaB TR:Q9Z9N1 (EMBL:AB016894) (448 aa) fasta scores: E(): 8.9e-94, 55.531% id in 452 aa; cytochrome ubiquinol oxidase 1106641 2860788 SAR1059 Staphylococcus aureus subsp. aureus MRSA252 cytochrome ubiquinol oxidase YP_040473.1 1105280 D 282458 CDS YP_040474.1 49483250 2860789 1106638..1107657 1 NC_002952.2 Similar to Pseudomonas aeruginosa cyanide insensitive terminal oxidase CioB TR:O07441 (EMBL:Y10528) (335 aa) fasta scores: E(): 2.4e-06, 21.951% id in 328 aa, and to Bacillus halodurans cytochrome D ubiquinol oxidase subunit II BH3974 TR:Q9K5W3 (EMBL:AP001520) (338 aa) fasta scores: E(): 4.3e-66, 53.550% id in 338 aa; hypothetical protein 1107657 2860789 SAR1060 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040474.1 1106638 D 282458 CDS YP_040475.1 49483251 2860790 1107790..1108452 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkqB SW:YKQB_BACSU (P39760) (221 aa) fasta scores: E(): 5.6e-51, 64.516% id in 217 aa, and to Bacillus halodurans potassium uptake protein BH2663 TR:Q9K9I4 (EMBL:AP001516) (220 aa) fasta scores: E(): 3.8e-48, 62.212% id in 217 aa; potassium transport protein 1108452 2860790 SAR1061 Staphylococcus aureus subsp. aureus MRSA252 potassium transport protein YP_040475.1 1107790 D 282458 CDS YP_040476.1 49483252 2860791 complement(1108800..1110497) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2662 TR:Q9K9I5 (EMBL:AP001516) (555 aa) fasta scores: E(): 1e-154, 67.446% id in 556 aa, and to Bacillus subtilis hypothetical protein YkqC SW:YKQC_BACSU (Q45493) (555 aa) fasta scores: E(): 2e-152, 67.086% id in 556 aa; hypothetical protein 1110497 2860791 SAR1063 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040476.1 1108800 R 282458 CDS YP_040477.1 49483253 2860792 complement(1110497..1110715) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2661 TR:Q9K9I6 (EMBL:AP001516) (69 aa) fasta scores: E(): 8.6e-11, 53.731% id in 67 aa, and to Bacillus subtilis hypothetical protein YkzG R:O31718 (EMBL:Z99111) (69 aa) fasta scores: E(): 3.7e-10, 56.061% id in 66 aa; hypothetical protein 1110715 2860792 SAR1064 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040477.1 1110497 R 282458 CDS YP_040478.1 49483254 2860793 complement(1111197..1111748) 1 NC_002952.2 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1111748 def 2860793 def Staphylococcus aureus subsp. aureus MRSA252 peptide deformylase YP_040478.1 1111197 R 282458 CDS YP_040479.1 49483255 2860794 1112113..1112739 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein in YkyA SW:YKYA_BACSU (P21884) (237 aa) fasta scores: E(): 7.1e-05, 24.880% id in 209 aa, and to Bacillus subtilis hypothetical protein YkyA TR:Q45496 (EMBL:AF012285) (205 aa) fasta scores: E(): 0.00011, 23.077% id in 195 aa; hypothetical protein 1112739 2860794 SAR1066 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040479.1 1112113 D 282458 CDS YP_040480.1 49483256 2859889 1112910..1114022 1 NC_002952.2 Similar to Bacillus stearothermophilus pyruvate dehydrogenase E1 component, alpha subunit PdhA SW:ODPA_BACST (P21873) (368 aa) fasta scores: E(): 2.6e-102, 74.931% id in 363 aa, and to Bacillus subtilis pyruvate dehydrogenase E1 component, alpha subunit PdhA SW:ODPA_BACSU (P21881) (370 aa) fasta scores: E(): 2.2e-103, 75.342% id in 365 aa; pyruvate dehydrogenase E1 component subunit alpha 1114022 pdhA 2859889 pdhA Staphylococcus aureus subsp. aureus MRSA252 pyruvate dehydrogenase E1 component subunit alpha YP_040480.1 1112910 D 282458 CDS YP_040481.1 49483257 2859890 1114026..1115003 1 NC_002952.2 Similar to Bacillus stearothermophilus pyruvate dehydrogenase E1 component, beta subunit PdhB SW:ODPB_BACST (P21874) (324 aa) fasta scores: E(): 4e-94, 75.926% id in 324 aa, and to Bacillus subtilis pyruvate dehydrogenase E1 component, beta subunit PdhB SW:ODPB_BACSU (P21882) (324 aa) fasta scores: E(): 8.2e-98, 77.469% id in 324 aa; pyruvate dehydrogenase E1 component subunit beta 1115003 pdhB 2859890 pdhB Staphylococcus aureus subsp. aureus MRSA252 pyruvate dehydrogenase E1 component subunit beta YP_040481.1 1114026 D 282458 CDS YP_040482.1 49483258 2859891 1115094..1116386 1 NC_002952.2 Similar to Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_BACST (P11961) (427 aa) fasta scores: E(): 1.6e-102, 70.208% id in 433 aa. Previously sequenced as Staphylococcus aureus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_STAAU (Q59821) (430 aa) fasta scores: E(): 3.7e-148, 99.535% id in 430 aa; branched-chain alpha-keto acid dehydrogenase E2 1116386 pdhC 2859891 pdhC Staphylococcus aureus subsp. aureus MRSA252 branched-chain alpha-keto acid dehydrogenase E2 YP_040482.1 1115094 D 282458 CDS YP_040483.1 49483259 2859892 1116390..1117796 1 NC_002952.2 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 1117796 pdhD 2859892 pdhD Staphylococcus aureus subsp. aureus MRSA252 dihydrolipoamide dehydrogenase YP_040483.1 1116390 D 282458 CDS YP_040484.1 49483260 2860795 1117967..1118242 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YfdD TR:Q9CI19 (EMBL:AE006288) (93 aa) fasta scores: E(): 2.8e-13, 51.685% id in 89 aa, and to Bacillus subtilis hypothetical protein YktA TR:Q45497 (EMBL:AF012285) (88 aa) fasta scores: E(): 2.8e-12, 44.828% id in 87 aa; hypothetical protein 1118242 2860795 SAR1071 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040484.1 1117967 D 282458 CDS YP_040485.1 49483261 2860796 1118386..1118925 1 NC_002952.2 Similar to Thermotoga maritima conserved hypothetical protein TM0656 TR:Q9WZC4 (EMBL:AE001739) (176 aa) fasta scores: E(): 3.8e-20, 40.805% id in 174 aa, and to Pseudomonas aeruginosa probable transcriptional regulator PA5301 TR:Q9HTQ3 (EMBL:AE004943) (182 aa) fasta scores: E(): 3e-07, 28.177% id in 181 aa; DNA-binding protein 1118925 2860796 SAR1072 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_040485.1 1118386 D 282458 CDS YP_040486.1 49483262 2860797 1118938..1120032 1 NC_002952.2 N-terminus is similar to N-terminal region of Escherichia coli spermidine/putrescine transport ATP-binding protein PotA SW:POTA_ECOLI (P23858) (378 aa) fasta scores: E(): 5.7e-50, 51.736% id in 288 aa. Full length CDS is similar to N-terminal region of Lactococcus lactis spermidine/putrescine ABC transporter ATP-binding protein PotA TR:Q9CGD4 (EMBL:AE006348) (428 aa) fasta scores: E(): 2.3e-78, 62.396% id in 359 aa; ABC transporter ATP-binding protein 1120032 2860797 SAR1073 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040486.1 1118938 D 282458 CDS YP_040487.1 49483263 2860798 1120025..1120822 1 NC_002952.2 Similar to Escherichia coli spermidine/putrescine ABC transporter permease PotB SW:POTB_ECOLI (P23860) (275 aa) fasta scores: E(): 9.8e-21, 29.885% id in 261 aa, and to Lactococcus lactis spermidine/putrescine ABC transporter permease PotB TR:Q9CGD3 (EMBL:AE006348) (262 aa) fasta scores: E(): 7.7e-47, 53.307% id in 257 aa; ABC transporter permease 1120822 2860798 SAR1074 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_040487.1 1120025 D 282458 CDS YP_040488.1 49483264 2860799 1120828..1121637 1 NC_002952.2 Similar to Escherichia coli spermidine/putrescine ABC transporter permease PotC SW:POTC_ECOLI (P23859) (264 aa) fasta scores: E(): 9.1e-28, 36.948% id in 249 aa, and to Streptococcus pyogenes spermidine/putrescine ABC transporter PotC TR:Q99ZS6 (EMBL:AE006553) (258 aa) fasta scores: E(): 7.2e-46, 52.756% id in 254 aa; ABC transporter permease 1121637 2860799 SAR1075 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_040488.1 1120828 D 282458 CDS YP_040489.1 49483265 2860800 1121637..1122710 1 NC_002952.2 Similar to Escherichia coli spermidine/putrescine-binding periplasmic protein precursor PotD SW:POTD_ECOLI (P23861) (348 aa) fasta scores: E(): 4.6e-43, 38.375% id in 357 aa, and to Streptococcus pyogenes spermidine/putrescine ABC transporter PotD TR:Q99ZS5 (EMBL:AE006553) (357 aa) fasta scores: E(): 3.3e-61, 44.972% id in 358 aa; ABC transporter 1122710 2860800 SAR1076 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter YP_040489.1 1121637 D 282458 CDS YP_040490.1 49483266 2860801 1122784..1123803 1 NC_002952.2 hypothetical protein 1123803 2860801 SAR1077 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040490.1 1122784 D 282458 CDS YP_040491.1 49483267 2860802 1124086..1124505 1 NC_002952.2 hypothetical protein 1124505 2860802 SAR1078 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040491.1 1124086 D 282458 CDS YP_040492.1 49483268 2860803 complement(1124587..1125939) 1 NC_002952.2 NRAMP (natural resistance-associated macrophage proteins) family protein. Similar to Pseudomonas aeruginosa manganese transport protein MntH1 SW:MNT1_PSEAE (Q9RPF3) (439 aa) fasta scores: E(): 1.7e-63, 44.235% id in 425 aa, and to Lactobacillus brevis manganese transporter HitA TR:BAB47552 (EMBL:AB035808) (464 aa) fasta scores: E(): 3.4e-92, 55.708% id in 438 aa; manganese transport protein MntH 1125939 2860803 SAR1079 Staphylococcus aureus subsp. aureus MRSA252 manganese transport protein MntH YP_040492.1 1124587 R 282458 CDS YP_040493.1 49483269 2860804 complement(1126123..1126737) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YktB TR:Q45498 (EMBL:AF012285) (212 aa) fasta scores: E(): 3.9e-28, 41.379% id in 203 aa, and to Bacillus halodurans hypothetical protein BH2637 TR:Q9K9K8 (EMBL:AP001516) (213 aa) fasta scores: E(): 6.9e-27, 38.916% id in 203 aa; hypothetical protein 1126737 2860804 SAR1080 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040493.1 1126123 R 282458 CDS YP_040494.1 49483270 2860805 1126894..1127721 1 NC_002952.2 Similar to Lycopersicon esculentum myo-inositol-1 IMP1 SW:MYO1_LYCES (P54926) (273 aa) fasta scores: E(): 6.9e-20, 36.000% id in 225 aa, and to Bacillus subtilis extragenic suppressor protein homologue SuhB SW:SUHB_BACSU (Q45499) (265 aa) fasta scores: E(): 1.6e-46, 49.804% id in 255 aa; inositol monophosphatase 1127721 2860805 SAR1081 Staphylococcus aureus subsp. aureus MRSA252 inositol monophosphatase YP_040494.1 1126894 D 282458 CDS YP_040495.1 49483271 2861154 complement(1127875..1128066) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2633 TR:Q9K9L2 (EMBL:AP001516) (61 aa) fasta scores: E(): 0.03, 31.034% id in 58 aa, and to Bacillus subtilis hypothetical protein YlaF SW:YLAF_BACSU (O07630) (62 aa) fasta scores: E(): 0.66, 31.667% id in 60 aa; hypothetical protein 1128066 2861154 SAR1082 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040495.1 1127875 R 282458 CDS YP_040496.1 49483272 2861245 1128168..1130015 1 NC_002952.2 Similar to Escherichia coli GTPase BipA TR:Q9EXN7 (EMBL:AJ278218) (607 aa) fasta scores: E(): 1.6e-118, 53.897% id in 603 aa, and to Bacillus subtilis GTP-binding protein BipA homologue SW:TYPA_BACSU (O07631) (612 aa) fasta scores: E(): 1.6e-171, 77.318% id in 604 aa. In enteropathogenic E. coli (EPEC) BipA undergoes tyrosine phosphorylation and mediates interactions with epithelial cells; BipA family GTPase 1130015 2861245 SAR1083 Staphylococcus aureus subsp. aureus MRSA252 BipA family GTPase YP_040496.1 1128168 D 282458 CDS YP_040497.1 49483273 2861246 complement(1130154..1130321) 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YlaI SW:YLAI_BACSU (O07633) (69 aa) fasta scores: E(): 4.2e-05, 45.238% id in 42 aa; hypothetical protein 1130321 2861246 SAR1084 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040497.1 1130154 R 282458 CDS YP_040498.1 49483274 2861247 complement(1130323..1130805) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YlaL SW:YLAL_BACSU (O07636) (161 aa) fasta scores: E(): 1.4e-10, 31.098% id in 164 aa, and to Bacillus halodurans hypothetical protein BH2628 TR:Q9K9L7 (EMBL:AP001516) (169 aa) fasta scores: E(): 6.5e-10, 33.793% id in 145 aa; hypothetical protein 1130805 2861247 SAR1085 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040498.1 1130323 R 282458 CDS YP_040499.1 49483275 2861248 1130946..1131221 1 NC_002952.2 depletion of this protein in Bacillus subtilis results in defects in cell morphology; crystal structure of Staphylococcus protein shows homodimer; ligand binding protein; hypothetical protein 1131221 2861248 SAR1086 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040499.1 1130946 D 282458 CDS YP_040500.1 49483276 2861249 1131535..1132761 1 NC_002952.2 Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cell division protein FtsW or b0089 SWALL:FTSW_ECOLI (SWALL:P16457) (414 aa) fasta scores: E(): 2.5e-31, 32.62% id in 377 aa, and to Enterococcus hirae probable cell division protein FtsW SWALL:FTSW_ENTHR (SWALL:Q47866) (397 aa) fasta scores: E(): 2.8e-40, 36.34% id in 399 aa; cell division protein 1132761 2861249 SAR1087 Staphylococcus aureus subsp. aureus MRSA252 cell division protein YP_040500.1 1131535 D 282458 CDS YP_040501.1 49483277 2861250 1133314..1136766 1 NC_002952.2 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 1136766 2861250 SAR1088 Staphylococcus aureus subsp. aureus MRSA252 pyruvate carboxylase YP_040501.1 1133314 D 282458 CDS YP_040502.1 49483278 2859250 complement(1137034..1137945) 1 NC_002952.2 Similar to Bacillus subtilis cytochrome aa3 controlling protein CtaA SW:CTAA_BACSU (P12946) (306 aa) fasta scores: E(): 2.9e-43, 41.883% id in 308 aa. Previously sequenced as Staphylococcus aureus heme A synthase, involved in long-term starvation survival and recovery, CtaA TR:O85704 (EMBL:AF072726) (303 aa) fasta scores: E(): 7.4e-117, 99.670% id in 303 aa; heme A synthase 1137945 ctaA 2859250 ctaA Staphylococcus aureus subsp. aureus MRSA252 heme A synthase YP_040502.1 1137034 R 282458 CDS YP_040503.1 49483279 2859251 1138396..1139307 1 NC_002952.2 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 1139307 ctaB 2859251 ctaB Staphylococcus aureus subsp. aureus MRSA252 protoheme IX farnesyltransferase YP_040503.1 1138396 D 282458 CDS YP_040504.1 49483280 2861251 1139332..1139793 1 NC_002952.2 Poor database matches. Similar to the C-terminal regions of Bacillus subtilis hypothetical protein YozB TR:O31845 (EMBL:Z99114) (178 aa) fasta scores: E(): 1.5e-06, 27.941% id in 136 aa, and to Bradyrhizobium japonicum cytochrome-c oxidase CoxP TR:Q45236 (EMBL:X68547) (240 aa) fasta scores: E(): 1.3, 26.230% id in 122 aa; hypothetical protein 1139793 2861251 SAR1091 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040504.1 1139332 D 282458 CDS YP_040505.1 49483281 2859637 1140120..1141157 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YlbC TR:O34586 (EMBL:Z99111) (346 aa) fasta scores: E(): 2.7e-24, 28.691% id in 359 aa, and to Bacillus halodurans hypothetical protein BH2604 TR:Q9K9P1 (EMBL:AP001516) (363 aa) fasta scores: E(): 3.6e-16, 25.620% id in 363 aa; hypothetical protein 1141157 2859637 SAR1092 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040505.1 1140120 D 282458 CDS YP_040506.1 49483282 2859638 1141173..1141607 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YlbF TR:O34412 (EMBL:Z99111) (149 aa) fasta scores: E(): 1.2e-17, 40.845% id in 142 aa, and to Bacillus halodurans hypothetical protein BH2596 TR:Q9K9P9 (EMBL:AP001516) (147 aa) fasta scores: E(): 6.4e-16, 40.876% id in 137 aa; hypothetical protein 1141607 2859638 SAR1093 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040506.1 1141173 D 282458 CDS YP_040507.1 49483283 2859639 complement(1141674..1142603) 1 NC_002952.2 Similar to Bacillus subtilis glycerophosphoryl diester phosphodiesterase GlpQ SW:GLPQ_BACSU (P37965) (293 aa) fasta scores: E(): 4.4e-13, 27.036% id in 307 aa, and to Bacillus halodurans glycerophosphodiester phosphodiesterase BH1080 TR:Q9KDY1 (EMBL:AP001510) (250 aa) fasta scores: E(): 1.8e-12, 33.984% id in 256 aa; hypothetical protein 1142603 2859639 SAR1094 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040507.1 1141674 R 282458 CDS YP_040508.1 49483284 2859640 1142842..1143096 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2594 TR:Q9K9Q1 (EMBL:AP001516) (92 aa) fasta scores: E(): 8e-05, 27.027% id in 74 aa, and to Bacillus subtilis hypothetical protein YlbG TR:O34658 (EMBL:Z99111) (90 aa) fasta scores: E(): 0.0004, 24.658% id in 73 aa; hypothetical protein 1143096 2859640 SAR1095 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040508.1 1142842 D 282458 CDS YP_040509.1 49483285 2860002 complement(1143099..1143488) 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans hypothetical protein BH2591 TR:Q9K9Q4 (EMBL:AP001516) (129 aa) fasta scores: E(): 9.5e-15, 33.594% id in 128 aa; hypothetical protein 1143488 2860002 SAR1096 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040509.1 1143099 R 282458 CDS YP_040510.1 49483286 2860003 1143558..1144100 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2590 TR:Q9K9Q5 (EMBL:AP001516) (189 aa) fasta scores: E(): 3.1e-26, 47.312% id in 186 aa, and to Bacillus subtilis hypothetical protein YlbH TR:O34331 (EMBL:Z99111) (164 aa) fasta scores: E(): 4.7e-25, 52.229% id in 157 aa; methylase 1144100 2860003 SAR1097 Staphylococcus aureus subsp. aureus MRSA252 methylase YP_040510.1 1143558 D 282458 CDS YP_040511.1 49483287 2859240 1144102..1144584 1 NC_002952.2 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1144584 coaD 2859240 coaD Staphylococcus aureus subsp. aureus MRSA252 phosphopantetheine adenylyltransferase YP_040511.1 1144102 D 282458 CDS YP_040512.1 49483288 2860004 complement(1144646..1145785) 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY0314 TR:Q9A1E8 (EMBL:AE006497) (368 aa) fasta scores: E(): 5.3e-30, 34.341% id in 364 aa, and to Bacillus subtilis hypothetical protein YlbM TR:O34513 (EMBL:Z99111) (415 aa) fasta scores: E(): 7.6e-17, 32.836% id in 402 aa; hypothetical protein 1145785 2860004 SAR1099 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040512.1 1144646 R 282458 CDS YP_040513.1 49483289 2860362 1145912..1146469 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YlbN TR:O34445 (EMBL:Z99111) (172 aa) fasta scores: E(): 3.8e-14, 33.511% id in 188 aa, and to Bacillus halodurans hypothetical protein BH2584 TR:Q9K9R1 (EMBL:AP001516) (169 aa) fasta scores: E(): 2.3e-13, 34.225% id in 187 aa; hypothetical protein 1146469 2860362 SAR1100 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040513.1 1145912 D 282458 CDS YP_040514.1 49483290 2860161 1146549..1146722 1 NC_002952.2 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1146722 rpmF 2860161 rpmF Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L32 YP_040514.1 1146549 D 282458 CDS YP_040515.1 49483291 2859674 complement(1146876..1148834) 1 NC_002952.2 Poor database matches. N-terminal region is similar to the C-terminus of Homo sapiens neurofilament triplet H protein NF-H SW:NFH_HUMAN (P12036) (1020 aa) fasta scores: E(): 1.9e-05, 24.107% id in 560 aa. Probable LPXTG-sorted surface protein; iron-regulated heme-iron binding protein 1148834 isdB 2859674 isdB Staphylococcus aureus subsp. aureus MRSA252 iron-regulated heme-iron binding protein YP_040515.1 1146876 R 282458 CDS YP_040516.1 49483292 2859673 complement(1149036..1150100) 1 NC_002952.2 N-terminus is similar to N-terminal region of Staphylococcus epidermidis lipase precursor GehD TR:Q9Z4M7 (EMBL:AF090142) (643 aa) fasta scores: E(): 0.0092, 23.827% id in 277 aa. Previously sequenced as Staphylococcus aureus 29-kDa cell surface protein precursor TR:Q9KW67 (EMBL:AB042826) (354 aa) fasta scores: E(): 1.9e-103, 100.000% id in 354 aa. Probable LPXTG-sorted surface protein; iron-regulated heme-iron binding protein 1150100 isdA 2859673 isdA Staphylococcus aureus subsp. aureus MRSA252 iron-regulated heme-iron binding protein YP_040516.1 1149036 R 282458 CDS YP_040517.1 49483293 2859675 1150309..1150992 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans hypothetical protein BH3299 TR:Q9K7R0 (EMBL:AP001518) (221 aa) fasta scores: E(): 7e-11, 28.037% id in 214 aa. Probable NPQTN-sorted surface protein; surface anchored protein 1150992 isdC 2859675 isdC Staphylococcus aureus subsp. aureus MRSA252 surface anchored protein YP_040517.1 1150309 D 282458 CDS YP_040518.1 49483294 2859676 1150992..1152068 1 NC_002952.2 Poor database matches. Similar to an internal region of Bacillus anthracis virulence plasmid pX01 hypothetical protein pXO1-90 TR:Q9X360 (EMBL:AF065404) (652 aa) fasta scores: E(): 0.28, 22.034% id in 295 aa CDS contains lysine-rich region, residues 155 to 297; hypothetical protein 1152068 isdD 2859676 isdD Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040518.1 1150992 D 282458 CDS YP_040519.1 49483295 2859677 1152065..1152943 1 NC_002952.2 Similar to Bacillus subtilis iron-uptake system binding protein precursor FeuA SW:FEUA_BACSU (P40409) (317 aa) fasta scores: E(): 6.7e-06, 25.820% id in 244 aa, and to Listeria monocytogenes lipoprotein FufA TR:Q9EXG4 (EMBL:AJ012345) (290 aa) fasta scores: E(): 2e-44, 48.789% id in 289 aa; transport system extracellular binding lipoprotein 1152943 isdE 2859677 isdE Staphylococcus aureus subsp. aureus MRSA252 transport system extracellular binding lipoprotein YP_040519.1 1152065 D 282458 CDS YP_040520.1 49483296 2859678 1152953..1153921 1 NC_002952.2 Similar to Escherichia coli iron citrate-dependent iron transport, membrane bound protein FecD SW:FECD_ECOLI (P15029) (318 aa) fasta scores: E(): 5e-29, 35.127% id in 316 aa, and to Bacillus halodurans ferrichrome ABC transporter BH3296 TR:Q9K7R3 (EMBL:AP001518) (328 aa) fasta scores: E(): 5.9e-43, 43.614% id in 321 aa; iron/heme permease 1153921 isdF 2859678 isdF Staphylococcus aureus subsp. aureus MRSA252 iron/heme permease YP_040520.1 1152953 D 282458 CDS YP_040521.1 49483297 2859503 1153983..1154717 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans hypothetical protein BH3294 TR:Q9K7R5 (EMBL:AP001518) (254 aa) fasta scores: E(): 1e-27, 38.462% id in 234 aa. C-terminus is similar to the C-terminal region of Streptococcus pyogenes hypothetical protein SPY0129 TR:Q9A1S1 (EMBL:AE006482) (237 aa) fasta scores: E(): 3.2e-17, 33.333% id in 183 aa; sortase 1154717 srtB 2859503 srtB Staphylococcus aureus subsp. aureus MRSA252 sortase YP_040521.1 1153983 D 282458 CDS YP_040522.1 49483298 2860363 1154736..1155059 1 NC_002952.2 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source; heme-degrading monooxygenase IsdG 1155059 2860363 SAR1109 Staphylococcus aureus subsp. aureus MRSA252 heme-degrading monooxygenase IsdG YP_040522.1 1154736 D 282458 CDS YP_040523.1 49483299 2860364 1155096..1155203 1 NC_002952.2 Doubtful CDS. No database matches; hypothetical protein 1155203 2860364 SAR1109a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040523.1 1155096 D 282458 CDS YP_040524.1 49483300 2860365 1155443..1156183 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YsgA TR:P94538 (EMBL:Z75208) (248 aa) fasta scores: E(): 2.1e-39, 45.783% id in 249 aa, and to Bacillus halodurans rRNA methylase BH3112 TR:Q9K894 (EMBL:AP001517) (251 aa) fasta scores: E(): 5.8e-39, 50.000% id in 252 aa; SpoU rRNA methylase 1156183 2860365 SAR1110 Staphylococcus aureus subsp. aureus MRSA252 SpoU rRNA methylase YP_040524.1 1155443 D 282458 CDS YP_040525.1 49483301 2859902 1156564..1157622 1 NC_002952.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1157622 pheS 2859902 pheS Staphylococcus aureus subsp. aureus MRSA252 phenylalanyl-tRNA synthetase subunit alpha YP_040525.1 1156564 D 282458 CDS YP_040526.1 49483302 2859903 1157622..1160024 1 NC_002952.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1160024 pheT 2859903 pheT Staphylococcus aureus subsp. aureus MRSA252 phenylalanyl-tRNA synthetase subunit beta YP_040526.1 1157622 D 282458 CDS YP_040527.1 49483303 2860366 complement(1160194..1161132) 1 NC_002952.2 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 1161132 2860366 SAR1113 Staphylococcus aureus subsp. aureus MRSA252 ribonuclease HIII YP_040527.1 1160194 R 282458 CDS YP_040528.1 49483304 2860367 1161508..1161774 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YshA TR:P94542 (EMBL:Z75208) (85 aa) fasta scores: E(): 1e-08, 46.154% id in 78 aa, and to Bacillus halodurans hypothetical protein BH3109 TR:Q9K897 (EMBL:AP001517) (91 aa) fasta scores: E(): 1.5e-06, 45.333% id in 75 aa; hypothetical protein 1161774 2860367 SAR1114 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040528.1 1161508 D 282458 CDS YP_040529.1 49483305 2860368 1161775..1162296 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YshB TR:P94543 (EMBL:Z75208) (177 aa) fasta scores: E(): 1.4e-10, 29.885% id in 174 aa, and to Bacillus halodurans hypothetical protein BH3108 TR:Q9K898 (EMBL:AP001517) (179 aa) fasta scores: E(): 5.1e-09, 25.731% id in 171 aa; hypothetical protein 1162296 2860368 SAR1115 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040529.1 1161775 D 282458 CDS YP_040530.1 49483306 2860369 1162369..1164081 1 NC_002952.2 Similar to Bacillus halodurans DNA-dependent DNA polymerase beta chain BH3107 TR:Q9K899 (EMBL:AP001517) (571 aa) fasta scores: E(): 5e-104, 53.439% id in 567 aa, and to Bacillus subtilis hypothetical protein YshC TR:P94544 (EMBL:Z75208) (570 aa) fasta scores: E(): 1.3e-101, 52.807% id in 570 aa; hypothetical protein 1164081 2860369 SAR1116 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040530.1 1162369 D 282458 CDS YP_040531.1 49483307 2860370 1164091..1166439 1 NC_002952.2 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange; recombination and DNA strand exchange inhibitor protein 1166439 2860370 SAR1117 Staphylococcus aureus subsp. aureus MRSA252 recombination and DNA strand exchange inhibitor protein YP_040531.1 1164091 D 282458 CDS YP_040532.1 49483308 2860405 1166612..1166926 1 NC_002952.2 Similar to Anabaena sp thioredoxin 1 TrxA SW:THI1_ANASO (P06544) (106 aa) fasta scores: E(): 9.4e-21, 54.286% id in 105 aa. Previously sequenced as Staphylococcus aureus thioredoxin TrxA TR:Q9ZEH4 (EMBL:AJ223480) (104 aa) fasta scores: E(): 9.6e-41, 100.000% id in 104 aa; thioredoxin 1166926 trxA 2860405 trxA Staphylococcus aureus subsp. aureus MRSA252 thioredoxin YP_040532.1 1166612 D 282458 CDS YP_040533.1 49483309 2860425 1167250..1169031 1 NC_002952.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1169031 uvrC 2860425 uvrC Staphylococcus aureus subsp. aureus MRSA252 excinuclease ABC subunit C YP_040533.1 1167250 D 282458 CDS YP_040534.1 49483310 2859131 1169355..1169969 1 NC_002952.2 Similar to Bacillus halodurans succinate dehydrogenase cytochrome b558 SdhC TR:Q9K8B3 (EMBL:AP001517) (209 aa) fasta scores: E(): 6.7e-44, 52.941% id in 204 aa, and to Bacillus subtilis succinate dehydrogenase cytochrome b558 subunit SdhC SW:DHSC_BACSU (P08064) (202 aa) fasta scores: E(): 1.5e-42, 54.040% id in 198 aa; succinate dehydrogenase cytochrome b558 1169969 sdhC 2859131 sdhC Staphylococcus aureus subsp. aureus MRSA252 succinate dehydrogenase cytochrome b558 YP_040534.1 1169355 D 282458 CDS YP_040535.1 49483311 2859129 1170021..1171787 1 NC_002952.2 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 1171787 sdhA 2859129 sdhA Staphylococcus aureus subsp. aureus MRSA252 succinate dehydrogenase flavoprotein subunit YP_040535.1 1170021 D 282458 CDS YP_040536.1 49483312 2859130 1171787..1172602 1 NC_002952.2 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 1172602 sdhB 2859130 sdhB Staphylococcus aureus subsp. aureus MRSA252 succinate dehydrogenase iron-sulfur subunit YP_040536.1 1171787 D 282458 CDS YP_040537.1 49483313 2861325 1172841..1173641 1 NC_002952.2 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1173641 murI 2861325 murI Staphylococcus aureus subsp. aureus MRSA252 glutamate racemase YP_040537.1 1172841 D 282458 CDS YP_040538.1 49483314 2860371 1173653..1174240 1 NC_002952.2 hydrolyzes non-standard nucleotides such as xanthine and inosine; nucleoside-triphosphatase 1174240 2860371 SAR1124 Staphylococcus aureus subsp. aureus MRSA252 nucleoside-triphosphatase YP_040538.1 1173653 D 282458 CDS YP_040539.1 49483315 2860372 1174233..1174736 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3066 TR:Q9K8E0 (EMBL:AP001517) (169 aa) fasta scores: E(): 3.4e-15, 34.375% id in 160 aa, and to Bacillus subtilis hypothetical protein YsnB SW:YSNB_BACSU (P94559) (171 aa) fasta scores: E(): 1.4e-13, 33.962% id in 159 aa; hypothetical protein 1174736 2860372 SAR1125 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040539.1 1174233 D 282458 CDS YP_040540.1 49483316 2860373 1174866..1175033 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start sites; hypothetical protein 1175033 2860373 SAR1126 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040540.1 1174866 D 282458 CDS YP_040541.1 49483317 2860374 1175227..1175544 1 NC_002952.2 No significant database matches to the full length CDS. C-terminus is similar to the C-terminal region of Staphylococcus aureus fibrinogen-binding protein precursor Fib TR:Q08691 (EMBL:X72013) (165 aa) fasta scores: E(): 0.00011, 40.909% id in 66 aa; hypothetical protein 1175544 2860374 SAR1127 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040541.1 1175227 D 282458 CDS YP_040542.1 49483318 2860376 1176949..1177455 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Mycoplasma pulmonis hypothetical protein MYPU_2270 TR:CAC13400 (EMBL:AL445563) (245 aa) fasta scores: E(): 0.028, 23.871% id in 155 aa; hypothetical protein 1177455 2860376 SAR1129 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040542.1 1176949 D 282458 CDS YP_040543.1 49483319 2860667 1177712..1178209 1 NC_002952.2 Highly similar to Staphylococcus aureus fibrinogen-binding protein precursor Fib TR:Q08691 (EMBL:X72013) (165 aa) fasta scores: E(): 8.7e-57, 94.545% id in 165 aa. Internal region of the CDS is similar internal regions of Staphylococcus aureus staphylocoagulase precursor SW:STC2_STAAU (P17855) (715 aa) fasta scores: E(): 6.9e-05, 40.541% id in 74 aa; fibrinogen-binding protein precursor 1178209 fib 2860667 fib Staphylococcus aureus subsp. aureus MRSA252 fibrinogen-binding protein precursor YP_040543.1 1177712 D 282458 CDS YP_040544.1 49483320 2860377 1178361..1178711 1 NC_002952.2 No significant database matches. Similar to SAR2035, 50.000% identity (50.893% ungapped) in 114 aa overlap; hypothetical protein 1178711 2860377 SAR1131 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040544.1 1178361 D 282458 CDS YP_040545.1 49483321 2860378 1178795..1179019 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start sites; hypothetical protein 1179019 2860378 SAR1132 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040545.1 1178795 D 282458 CDS YP_040546.1 49483322 2860379 complement(1178960..1179145) 1 NC_002952.2 hypothetical protein 1179145 2860379 SAR1133 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040546.1 1178960 R 282458 CDS YP_040547.1 49483323 2860380 complement(1179346..1179594) 1 NC_002952.2 hypothetical protein 1179594 2860380 SAR1133a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040547.1 1179346 R 282458 CDS YP_040548.1 49483324 2860381 complement(1179755..1179988) 1 NC_002952.2 hypothetical protein 1179988 2860381 SAR1134 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040548.1 1179755 R 282458 CDS YP_040549.1 49483325 2860382 1182069..1182215 1 NC_002952.2 Doubtful CDS. No database matches; hypothetical protein 1182215 2860382 SAR1136a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040549.1 1182069 D 282458 CDS YP_040550.1 49483326 2860383 1182199..1182399 1 NC_002952.2 Poor database matches. Similar to an internal region of bacteriophage APSE-1 hypothetical protein P2 SW:VP02_BPAPS (Q9T1U6) (94 aa) fasta scores: E(): 9.9, 29.508% id in 61 aa. Similar to SAR1303, 54.545% identity (54.545% ungapped) in 66 aa overlap; hypothetical protein 1182399 2860383 SAR1137 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040550.1 1182199 D 282458 CDS YP_040551.1 49483327 2860384 1182701..1184347 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 7.6e-199, 99.270% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 4e-99, 51.923% id in 520 aa; transposase 1184347 2860384 SAR1138 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040551.1 1182701 D 282458 CDS YP_040552.1 49483328 2860385 complement(1184717..1185433) 1 NC_002952.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 1185433 2860385 SAR1139 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein YP_040552.1 1184717 R 282458 CDS YP_040553.1 49483329 2860386 complement(1185542..1186267) 1 NC_002952.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 1186267 2860386 SAR1140 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein YP_040553.1 1185542 R 282458 CDS YP_040554.1 49483330 2860387 complement(1186377..1187102) 1 NC_002952.2 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 1187102 2860387 SAR1141 Staphylococcus aureus subsp. aureus MRSA252 superantigen-like protein YP_040554.1 1186377 R 282458 CDS YP_040555.1 49483331 2861471 1187532..1188533 1 NC_002952.2 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1188533 otc 2861471 otc Staphylococcus aureus subsp. aureus MRSA252 ornithine carbamoyltransferase YP_040555.1 1187532 D 282458 CDS YP_040556.1 49483332 2860388 1188556..1189488 1 NC_002952.2 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1189488 2860388 SAR1143 Staphylococcus aureus subsp. aureus MRSA252 carbamate kinase YP_040556.1 1188556 D 282458 CDS YP_040557.1 49483333 2860389 1189659..1191215 1 NC_002952.2 Similar to Haemophilus influenzae hypothetical protein HI0594 SW:YFCC_HAEIN (P44023) (509 aa) fasta scores: E(): 2.8e-109, 58.527% id in 516 aa, and to Escherichia coli hypothetical protein YfcC SW:YFCC_ECOLI (P39263) (506 aa) fasta scores: E(): 1.3e-34, 28.977% id in 528 aa. C-terminal region is similar to SAR0067, 94.333% identity (94.333% ungapped) in 300 aa overlap; hypothetical protein 1191215 2860389 SAR1144 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040557.1 1189659 D 282458 CDS YP_040558.1 49483334 2860390 1191522..1191749 1 NC_002952.2 Poor database matches. Similar to Escherichia coli O157:H7 hypothetical membrane protein ECS4748 TR:BAB38171 (EMBL:AP002567) (99 aa) fasta scores: E(): 4.1, 30.357% id in 56 aa; hypothetical protein 1191749 2860390 SAR1146 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040558.1 1191522 D 282458 CDS YP_040559.1 49483335 2860391 complement(1192065..1193012) 1 NC_002952.2 Similar to Staphylococcus hyicus exfoliative toxin A SHETA TR:Q9FDT4 (EMBL:AB036768) (306 aa) fasta scores: E(): 4.2e-87, 80.132% id in 302 aa, and to Streptococcus pyogenes exfoliative toxin SPY0918 TR:Q9A061 (EMBL:AE006541) (302 aa) fasta scores: E(): 1.7e-37, 41.584% id in 303 aa; hypothetical protein 1193012 2860391 SAR1147 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040559.1 1192065 R 282458 CDS YP_040560.1 49483336 2861252 1193259..1193456 1 NC_002952.2 DNA-binding protein 1193456 2861252 SAR1148 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_040560.1 1193259 D 282458 CDS YP_040561.1 49483337 2861253 1194355..1194489 1 NC_002952.2 Similar to Staphylococcus haemolyticus antibacterial protein 3 SW:GGI3_STAHA (P11699) (44 aa) fasta scores: E(): 2.1e-08, 70.455% id in 44 aa, and to Staphylococcus lugdunensis hemolysin SLUSH-C TR:P95771 (EMBL:U73444) (43 aa) fasta scores: E(): 0.032, 40.476% id in 42 aa; anti protein 1194489 2861253 SAR1150 Staphylococcus aureus subsp. aureus MRSA252 anti protein YP_040561.1 1194355 D 282458 CDS YP_040562.1 49483338 2861254 1194622..1195308 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfnB TR:O06480 (EMBL:D86418) (235 aa) fasta scores: E(): 5.2e-29, 41.333% id in 225 aa, and to Streptococcus pyogenes hypothetical protein SPY1066 TR:Q99ZU5 (EMBL:AE006551) (233 aa) fasta scores: E(): 1.2e-20, 31.111% id in 225 aa; haloacid dehalogenase-like hydrolase 1195308 2861254 SAR1151 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_040562.1 1194622 D 282458 CDS YP_040563.1 49483339 2861255 complement(1195416..1195856) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YlbP TR:O34468 (EMBL:Z99111) (160 aa) fasta scores: E(): 2.7e-22, 46.309% id in 149 aa, and to Bacillus halodurans hypothetical protein BH2580 TR:Q9K9R5 (EMBL:AP001516) (169 aa) fasta scores: E(): 1.4e-20, 43.836% id in 146 aa; hypothetical protein 1195856 2861255 SAR1152 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040563.1 1195416 R 282458 CDS YP_040564.1 49483340 2861256 1196051..1197664 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YllA SW:YLLA_BACSU (P55342) (539 aa) fasta scores: E(): 1.5e-49, 32.103% id in 542 aa, and to Bacillus halodurans hypothetical protein BH2577 TR:Q9K9R8 (EMBL:AP001516) (538 aa) fasta scores: E(): 3e-44, 31.610% id in 503 aa; hypothetical protein 1197664 2861256 SAR1153 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040564.1 1196051 D 282458 CDS YP_040565.1 49483341 2861257 1197808..1198239 1 NC_002952.2 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1198239 2861257 SAR1154 Staphylococcus aureus subsp. aureus MRSA252 cell division protein MraZ YP_040565.1 1197808 D 282458 CDS YP_040566.1 49483342 2861258 1198255..1199190 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YllC SW:YLXA_BACSU (Q07876) (311 aa) fasta scores: E(): 9.9e-77, 64.610% id in 308 aa, and to Enterococcus hirae hypothetical protein MraW TR:O07665 (EMBL:Y13922) (319 aa) fasta scores: E(): 8.5e-74, 64.423% id in 312 aa; S-adenosyl-methyltransferase MraW 1199190 mraW 2861258 mraW Staphylococcus aureus subsp. aureus MRSA252 S-adenosyl-methyltransferase MraW YP_040566.1 1198255 D 282458 CDS YP_040567.1 49483343 2861259 1199204..1199605 1 NC_002952.2 Similar to Bacillus subtilis cell division protein FtsL homologue SW:FTSL_BACSU (Q07867) (117 aa) fasta scores: E(): 0.0016, 26.786% id in 112 aa, and to Staphylococcus aureus. Previously sequenced as cell division protein YllD TR:O07321 (EMBL:U94706) (133 aa) fasta scores: E(): 2.6e-44, 100.000% id in 133 aa; cell division protein 1199605 2861259 SAR1156 Staphylococcus aureus subsp. aureus MRSA252 cell division protein YP_040567.1 1199204 D 282458 CDS YP_040568.1 49483344 2861478 1199586..1201820 1 NC_002952.2 Similar to Bacillus subtilis penicillin-binding protein 2B PbpB SW:PBPB_BACSU (Q07868) (716 aa) fasta scores: E(): 2.2e-98, 40.503% id in 716 aa. Previously sequenced as Staphylococcus aureus penicillin-binding protein 1 PbpA TR:Q53725 (EMBL:U94706) (744 aa) fasta scores: E(): 0, 99.866% id in 744 aa; penicillin-binding protein 1 1201820 pbpA 2861478 pbpA Staphylococcus aureus subsp. aureus MRSA252 penicillin-binding protein 1 YP_040568.1 1199586 D 282458 CDS YP_040569.1 49483345 2861309 1202112..1203077 1 NC_002952.2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1203077 mraY 2861309 mraY Staphylococcus aureus subsp. aureus MRSA252 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_040569.1 1202112 D 282458 CDS YP_040570.1 49483346 2861322 1203079..1204428 1 NC_002952.2 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1204428 murD 2861322 murD Staphylococcus aureus subsp. aureus MRSA252 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_040570.1 1203079 D 282458 CDS YP_040571.1 49483347 2861260 1204441..1205763 1 NC_002952.2 Similar to Bacillus subtilis division initiation protein Dds SW:DIVB_BACSU (P16655) (263 aa) fasta scores: E(): 3.3e-15, 28.897% id in 263 aa. Previously sequenced as Staphylococcus aureus cell division protein Div1B TR:O07324 (EMBL:U94706) (439 aa) fasta scores: E(): 8.7e-133, 96.811% id in 439 aa; cell division protein 1205763 2861260 SAR1160 Staphylococcus aureus subsp. aureus MRSA252 cell division protein YP_040571.1 1204441 D 282458 CDS YP_040572.1 49483348 2860683 1205869..1207275 1 NC_002952.2 Similar to Bacillus subtilis cell division protein FtsA SW:FTSA_BACSU (P28264) (440 aa) fasta scores: E(): 1.7e-37, 30.687% id in 466 aa. Previously sequenced as Staphylococcus aureus cell division protein FtsA SW:FTSA_STAAU (O07325) (471 aa) fasta scores: E(): 9.5e-141, 89.451% id in 474 aa; cell division protein 1207275 ftsA 2860683 ftsA Staphylococcus aureus subsp. aureus MRSA252 cell division protein YP_040572.1 1205869 D 282458 CDS YP_040573.1 49483349 2860685 1207308..1208480 1 NC_002952.2 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1208480 ftsZ 2860685 ftsZ Staphylococcus aureus subsp. aureus MRSA252 cell division protein FtsZ YP_040573.1 1207308 D 282458 CDS YP_040574.1 49483350 2861261 1208738..1209529 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YlmD SW:YLMD_BACSU (O31726) (278 aa) fasta scores: E(): 2.1e-27, 31.984% id in 247 aa, and to Bacillus halodurans hypothetical protein BH2551 TR:Q9K9U4 (EMBL:AP001515) (273 aa) fasta scores: E(): 3.6e-24, 34.274% id in 248 aa; hypothetical protein 1209529 2861261 SAR1163 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040574.1 1208738 D 282458 CDS YP_040575.1 49483351 2861262 1209547..1210221 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2550 TR:Q9K9U5 (EMBL:AP001515) (228 aa) fasta scores: E(): 5e-42, 53.982% id in 226 aa, and to Bacillus subtilis hypothetical protein YlmE SW:YLME_BACSU (O31727) (230 aa) fasta scores: E(): 5.1e-42, 55.357% id in 224 aa; hypothetical protein 1210221 2861262 SAR1164 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040575.1 1209547 D 282458 CDS YP_040576.1 49483352 2861263 1210218..1210781 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY1518 TR:Q99YV9 (EMBL:AE006585) (218 aa) fasta scores: E(): 1.1e-05, 25.234% id in 214 aa. C-terminus is similar to the C-terminal region of Bacillus subtilis hypothetical protein YlmF TR:O31728 (EMBL:Z99112) (149 aa) fasta scores: E(): 1.3e-18, 56.198% id in 121 aa; hypothetical protein 1210781 2861263 SAR1165 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040576.1 1210218 D 282458 CDS YP_040577.1 49483353 2861264 1210793..1211083 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YlmG TR:O31729 (EMBL:Z99112) (90 aa) fasta scores: E(): 2.4e-14, 51.724% id in 87 aa, and to Bacillus halodurans hypothetical protein BH2548 TR:Q9K9U7 (EMBL:AP001515) (84 aa) fasta scores: E(): 8.2e-12, 46.988% id in 83 aa; hypothetical protein 1211083 2861264 SAR1166 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040577.1 1210793 D 282458 CDS YP_040578.1 49483354 2861265 1211166..1211972 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2547 TR:Q9K9U8 (EMBL:AP001515) (258 aa) fasta scores: E(): 7.5e-40, 48.193% id in 249 aa, and to Bacillus subtilis hypothetical protein YlmH TR:P71020 (EMBL:U60901) (257 aa) fasta scores: E(): 4.6e-33, 40.079% id in 252 aa; hypothetical protein 1211972 2861265 SAR1167 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040578.1 1211166 D 282458 CDS YP_040579.1 49483355 2861266 1211996..1212592 1 NC_002952.2 Similar to Bacillus subtilis minicell-associated protein DivIVA TR:P71021 (EMBL:U60901) (164 aa) fasta scores: E(): 1.9e-17, 41.139% id in 158 aa, and to Bacillus halodurans cell-division initiation protein BH2546 TR:Q9K9U9 (EMBL:AP001515) (165 aa) fasta scores: E(): 2.8e-14, 35.570% id in 149 aa. Contains coiled-coiled domain, residues 36 to 53; hypothetical protein 1212592 2861266 SAR1168 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040579.1 1211996 D 282458 CDS YP_040580.1 49483356 2859661 1212813..1215566 1 NC_002952.2 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1215566 ileS 2859661 ileS Staphylococcus aureus subsp. aureus MRSA252 isoleucyl-tRNA synthetase YP_040580.1 1212813 D 282458 CDS YP_040581.1 49483357 2861267 complement(1215677..1216624) 1 NC_002952.2 Identical to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 2.7e-127, 100.000% id in 315 aa, and similar to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 2.9e-71, 58.413% id in 315 aa; transposase 1216624 2861267 SAR1170 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040581.1 1215677 R 282458 CDS YP_040582.1 49483358 2861268 1216898..1217695 1 NC_002952.2 N-terminal region is similar to Rhodococcus globerulus biphenyl-2,3-diol 1,2-dioxygenase III bphC3 SW:BHC3_RHOGO (P47233) (189 aa) fasta scores: E(): 0.011, 23.837% id in 172 aa. Full length CDS is similar to Rhizobium loti hypothetical protein MLR0078 TR:BAB47738 (EMBL:AP002994) (270 aa) fasta scores: E(): 2.6e-15, 27.273% id in 253 aa; glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein 1217695 2861268 SAR1171 Staphylococcus aureus subsp. aureus MRSA252 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein YP_040582.1 1216898 D 282458 CDS YP_040583.1 49483359 2859810 1217944..1218435 1 NC_002952.2 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1218435 lspA 2859810 lspA Staphylococcus aureus subsp. aureus MRSA252 lipoprotein signal peptidase YP_040583.1 1217944 D 282458 CDS YP_040584.1 49483360 2861269 1218435..1219352 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YlyB SW:YLYB_BACSU (Q45480) (303 aa) fasta scores: E(): 5.9e-76, 65.217% id in 299 aa, and to Bacillus halodurans hypothetical protein BH2542 TR:Q9K9V3 (EMBL:AP001515) (305 aa) fasta scores: E(): 1.6e-69, 61.538% id in 299 aa; RNA pseudouridylate synthase 1219352 2861269 SAR1173 Staphylococcus aureus subsp. aureus MRSA252 RNA pseudouridylate synthase YP_040584.1 1218435 D 282458 CDS YP_040585.1 49483361 2859291 1219754..1220281 1 NC_002952.2 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 1220281 pyrR 2859291 pyrR Staphylococcus aureus subsp. aureus MRSA252 bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase YP_040585.1 1219754 D 282458 CDS YP_040586.1 49483362 2859290 1220499..1221806 1 NC_002952.2 Similar to Bacillus subtilis uracil permease PyrP SW:PYRP_BACSU (P39766) (434 aa) fasta scores: E(): 3.9e-74, 55.504% id in 427 aa, and to Bacillus caldolyticus uracil permease PyrP SW:PYRP_BACCL (P41006) (432 aa) fasta scores: E(): 4.8e-82, 58.993% id in 417 aa; uracil permease 1221806 pyrP 2859290 pyrP Staphylococcus aureus subsp. aureus MRSA252 uracil permease YP_040586.1 1220499 D 282458 CDS YP_040587.1 49483363 2859284 1221834..1222715 1 NC_002952.2 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 1222715 pyrB 2859284 pyrB Staphylococcus aureus subsp. aureus MRSA252 aspartate carbamoyltransferase catalytic subunit YP_040587.1 1221834 D 282458 CDS YP_040588.1 49483364 2859285 1222733..1224007 1 NC_002952.2 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1224007 pyrC 2859285 pyrC Staphylococcus aureus subsp. aureus MRSA252 dihydroorotase YP_040588.1 1222733 D 282458 CDS YP_040589.1 49483365 2859282 1224009..1225109 1 NC_002952.2 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1225109 pyrAA 2859282 pyrAA Staphylococcus aureus subsp. aureus MRSA252 carbamoyl phosphate synthase small subunit YP_040589.1 1224009 D 282458 CDS YP_040590.1 49483366 2859283 1225102..1228275 1 NC_002952.2 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1228275 carB 2859283 carB Staphylococcus aureus subsp. aureus MRSA252 carbamoyl phosphate synthase large subunit YP_040590.1 1225102 D 282458 CDS YP_040591.1 49483367 2859287 1228382..1229077 1 NC_002952.2 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1229077 pyrF 2859287 pyrF Staphylococcus aureus subsp. aureus MRSA252 orotidine 5'-phosphate decarboxylase YP_040591.1 1228382 D 282458 CDS YP_040592.1 49483368 2859286 1229077..1229688 1 NC_002952.2 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 1229688 pyrE 2859286 pyrE Staphylococcus aureus subsp. aureus MRSA252 orotate phosphoribosyltransferase YP_040592.1 1229077 D 282458 CDS YP_040593.1 49483369 2861270 1229718..1229930 1 NC_002952.2 hypothetical protein 1229930 2861270 SAR1182 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040593.1 1229718 D 282458 CDS YP_040594.1 49483370 2861271 1230367..1230768 1 NC_002952.2 Similar to Pseudomonas aeruginosa hypothetical protein PA1358 TR:Q9I3Y6 (EMBL:AE004565) (132 aa) fasta scores: E(): 1.9e-15, 40.625% id in 128 aa, and to the N-terminal region of Rhizobium loti hypothetical protein MLL5357 TR:BAB51820 (EMBL:AP003006) (156 aa) fasta scores: E(): 9e-06, 35.115% id in 131 aa; hypothetical protein 1230768 2861271 SAR1183 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040594.1 1230367 D 282458 CDS YP_040595.1 49483371 2861272 complement(1231031..1232728) 1 NC_002952.2 Similar to Bacillus subtilis fibronectin-binding protein YloA TR:O34693 (EMBL:AJ000974) (572 aa) fasta scores: E(): 2.2e-91, 46.410% id in 571 aa, and to Bacillus halodurans possible fibronectin/fibrinogen-binding protein BH2516 TR:Q9K9X8 (EMBL:AP001515) (570 aa) fasta scores: E(): 8.1e-88, 44.386% id in 570 aa. Contains coiled-coiled domain, residues 296 to 312; hypothetical protein 1232728 2861272 SAR1184 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040595.1 1231031 R 282458 CDS YP_040596.1 49483372 2861273 1233003..1233626 1 NC_002952.2 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1233626 gmk 2861273 gmk Staphylococcus aureus subsp. aureus MRSA252 guanylate kinase YP_040596.1 1233003 D 282458 CDS YP_040597.1 49483373 2861274 1233626..1233844 1 NC_002952.2 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1233844 rpoZ 2861274 rpoZ Staphylococcus aureus subsp. aureus MRSA252 DNA-directed RNA polymerase subunit omega YP_040597.1 1233626 D 282458 CDS YP_040598.1 49483374 2861275 1234060..1235259 1 NC_002952.2 Similar to Bacillus halodurans flavoprotein BH2510 TR:Q9K9Y4 (EMBL:AP001515) (404 aa) fasta scores: E(): 6.3e-76, 53.083% id in 373 aa, and to Bacillus subtilis hypothetical protein YloI TR:O35033 (EMBL:Z99112) (406 aa) fasta scores: E(): 1.4e-75, 54.315% id in 394 aa; flavoprotein 1235259 2861275 SAR1187 Staphylococcus aureus subsp. aureus MRSA252 flavoprotein YP_040598.1 1234060 D 282458 CDS YP_040599.1 49483375 2860151 1235259..1237667 1 NC_002952.2 Similar to Escherichia coli primosomal protein n' PriA SW:PRIA_ECOLI (P17888) (732 aa) fasta scores: E(): 8.6e-76, 35.115% id in 786 aa, and to Bacillus subtilis primosomal protein n' PriA SW:PRIA_BACSU (P94461) (805 aa) fasta scores: E(): 1.3e-151, 50.619% id in 808 aa; primosomal protein n' 1237667 priA 2860151 priA Staphylococcus aureus subsp. aureus MRSA252 primosomal protein n' YP_040599.1 1235259 D 282458 CDS YP_040600.1 49483376 2861276 1238170..1239123 1 NC_002952.2 Poor database matches. C-terminus is similar to internal region of Bacillus subtilis hypothetical protein YkvD protein ykvD TR:O31671 (EMBL:Z99111) (506 aa) fasta scores: E(): 6.4, 23.194% id in 263 aa; lipoprotein 1239123 2861276 SAR1189 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_040600.1 1238170 D 282458 CDS YP_040601.1 49483377 2861277 complement(1239286..1239564) 1 NC_002952.2 Poor database matches. Similar to Borrelia burgdorferi conserved hypothetical protein BBQ01 TR:Q9S015 (EMBL:AE001584) (89 aa) fasta scores: E(): 0.0016, 31.818% id in 88 aa. C-terminus is similar to the N-terminal region of Synechocystis sp hypothetical protein SLL0498 TR:Q55491 (EMBL:D64006) (150 aa) fasta scores: E(): 2.3e-06, 52.000% id in 50 aa. C-terminus is similar to the C-terminal region of SAR1013, 58.209% identity (59.091% ungapped) in 67 aa overlap; hypothetical protein 1239564 2861277 SAR1190 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040601.1 1239286 R 282458 CDS YP_040602.1 49483378 2859267 1239788..1240276 1 NC_002952.2 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1240276 def 2859267 def Staphylococcus aureus subsp. aureus MRSA252 peptide deformylase YP_040602.1 1239788 D 282458 CDS YP_040603.1 49483379 2861278 1240269..1241204 1 NC_002952.2 Similar to Escherichia coli methionyl-tRNA formyltransferase Fmt SW:FMT_ECOLI (P23882) (314 aa) fasta scores: E(): 9.7e-41, 39.228% id in 311 aa, and to Bacillus halodurans methionyl-tRNA formyltransferase BH2508 TR:Q9K9Y6 (EMBL:AP001515) (317 aa) fasta scores: E(): 7.4e-66, 59.355% id in 310 aa; methionyl-tRNA formyltransferase 1241204 2861278 SAR1192 Staphylococcus aureus subsp. aureus MRSA252 methionyl-tRNA formyltransferase YP_040603.1 1240269 D 282458 CDS YP_040604.1 49483380 2861279 1241201..1242508 1 NC_002952.2 Similar to Escherichia coli protein hypothetical protein Sun SW:SUN_ECOLI (P36929) (429 aa) fasta scores: E(): 7.7e-31, 29.306% id in 447 aa, and to Bacillus subtilis hypothetical protein Sun SW:SUN_BACSU (P94464) (447 aa) fasta scores: E(): 1.4e-58, 40.724% id in 442 aa; hypothetical protein 1242508 2861279 SAR1193 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040604.1 1241201 D 282458 CDS YP_040605.1 49483381 2861280 1242511..1243605 1 NC_002952.2 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 1243605 2861280 SAR1194 Staphylococcus aureus subsp. aureus MRSA252 ribosomal RNA large subunit methyltransferase N YP_040605.1 1242511 D 282458 CDS YP_040606.1 49483382 2861281 1243612..1244355 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2505 TR:Q9K9Y9 (EMBL:AP001515) (249 aa) fasta scores: E(): 3.2e-33, 42.917% id in 240 aa, and to Bacillus subtilis hypothetical protein YloO TR:O34779 (EMBL:Z99112) (254 aa) fasta scores: E(): 1.6e-30, 42.324% id in 241 aa; protein phosphatase 1244355 2861281 SAR1195 Staphylococcus aureus subsp. aureus MRSA252 protein phosphatase YP_040606.1 1243612 D 282458 CDS YP_040607.1 49483383 2859907 1244352..1246346 1 NC_002952.2 N-terminus is similar to N-terminal region of Myxococcus xanthus serine/threonine-protein kinase Pkn1 SW:PKN1_MYXXA (P33973) (693 aa) fasta scores: E(): 8.5e-23, 34.317% id in 271 aa. Previously sequenced as Staphylococcus aureus protein kinase PknB TR:Q9KX10 (EMBL:Y13639) (388 aa) fasta scores: E(): 7e-131, 100.000% id in 388 aa; serine/threonine-protein kinase 1246346 pknB 2859907 pknB Staphylococcus aureus subsp. aureus MRSA252 serine/threonine-protein kinase YP_040607.1 1244352 D 282458 CDS YP_040608.1 49483384 2861282 1246574..1247449 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YloQ TR:O34530 (EMBL:Z99112) (298 aa) fasta scores: E(): 9.8e-44, 44.667% id in 300 aa, and to Lactococcus lactis hypothetical protein YuaD TR:Q9CEB7 (EMBL:AE006423) (307 aa) fasta scores: E(): 4e-43, 45.302% id in 298 aa; hypothetical protein 1247449 2861282 SAR1197 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040608.1 1246574 D 282458 CDS YP_040609.1 49483385 2861283 1247450..1248094 1 NC_002952.2 Similar to Spinacia oleracea ribulose-phosphate 3-epimerase precursor Rpe SW:RPE_SPIOL (Q43157) (285 aa) fasta scores: E(): 6.6e-36, 51.905% id in 210 aa, and to Bacillus halodurans ribulose-phosphate 3-epimerase BH2502 TR:Q9K9Z2 (EMBL:AP001515) (216 aa) fasta scores: E(): 3.2e-41, 54.673% id in 214 aa. The S. oleracea protein is extented by 60 residues at the N-terminus; ribulose-phosphate 3-epimerase 1248094 2861283 SAR1198 Staphylococcus aureus subsp. aureus MRSA252 ribulose-phosphate 3-epimerase YP_040609.1 1247450 D 282458 CDS YP_040610.1 49483386 2861284 1248101..1248742 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YloS TR:O34664 (EMBL:Z99112) (214 aa) fasta scores: E(): 4.4e-27, 43.192% id in 213 aa. Internal region of the CDS is similar to an internal region of Mus musculus thiamin pyrophosphokinase TPK1 TR:Q9R0M5 (EMBL:AB027568) (243 aa) fasta scores: E(): 4.9e-05, 26.087% id in 161 aa; hypothetical protein 1248742 2861284 SAR1199 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040610.1 1248101 D 282458 CDS YP_040611.1 49483387 2860922 complement(1249123..1249311) 1 NC_002952.2 required for 70S ribosome assembly; 50S ribosomal protein L28 1249311 rpmB 2860922 rpmB Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L28 YP_040611.1 1249123 R 282458 CDS YP_040612.1 49483388 2861285 1249754..1250128 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YloU TR:O34318 (EMBL:Z99112) (120 aa) fasta scores: E(): 8.7e-26, 60.504% id in 119 aa, and to Bacillus halodurans hypothetical protein BH2499 TR:Q9K9Z5 (EMBL:AP001515) (120 aa) fasta scores: E(): 1.7e-24, 55.462% id in 119 aa; hypothetical protein 1250128 2861285 SAR1201 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040612.1 1249754 D 282458 CDS YP_040613.1 49483389 2861286 1250143..1251789 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YloV TR:O34751 (EMBL:Z99112) (553 aa) fasta scores: E(): 1.6e-111, 55.354% id in 551 aa, and to Bacillus halodurans hypothetical protein BH2498 TR:Q9K9Z6 (EMBL:AP001515) (557 aa) fasta scores: E(): 7.4e-105, 52.338% id in 556 aa; hypothetical protein 1251789 2861286 SAR1202 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040613.1 1250143 D 282458 CDS YP_040614.1 49483390 2859302 1251979..1254039 1 NC_002952.2 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1254039 recG 2859302 recG Staphylococcus aureus subsp. aureus MRSA252 ATP-dependent DNA helicase RecG YP_040614.1 1251979 D 282458 CDS YP_040615.1 49483391 2861287 1254257..1254814 1 NC_002952.2 negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria; fatty acid biosynthesis transcriptional regulator 1254814 2861287 SAR1204 Staphylococcus aureus subsp. aureus MRSA252 fatty acid biosynthesis transcriptional regulator YP_040615.1 1254257 D 282458 CDS YP_040616.1 49483392 2861288 1254819..1255805 1 NC_002952.2 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1255805 2861288 SAR1205 Staphylococcus aureus subsp. aureus MRSA252 glycerol-3-phosphate acyltransferase PlsX YP_040616.1 1254819 D 282458 CDS YP_040617.1 49483393 2859617 1255798..1256724 1 NC_002952.2 Similar to Escherichia coli malonyl CoA-acyl carrier protein transacylase FabD SW:FABD_ECOLI (P25715) (308 aa) fasta scores: E(): 9e-38, 39.931% id in 288 aa, and to Bacillus subtilis malonyl CoA-acyl carrier protein transacylase FabD SW:FABD_BACSU (P71019) (317 aa) fasta scores: E(): 6.3e-47, 46.711% id in 304 aa; malonyl CoA-ACP transacylase 1256724 fabD 2859617 fabD Staphylococcus aureus subsp. aureus MRSA252 malonyl CoA-ACP transacylase YP_040617.1 1255798 D 282458 CDS YP_040618.1 49483394 2859619 1256711..1257451 1 NC_002952.2 Similar to Bacillus subtilis 3-oxoacyl-[acyl-carrier protein] reductase FabG SW:FABG_BACSU (P51831) (246 aa) fasta scores: E(): 1.2e-54, 64.228% id in 246 aa, and to Bacillus halodurans 3-oxoacyl-[acyl-carrier protein] reductase BH2491 TR:Q9KA03 (EMBL:AP001515) (246 aa) fasta scores: E(): 1.8e-55, 67.886% id in 246 aa; 3-oxoacyl-ACP reductase 1257451 fabG 2859619 fabG Staphylococcus aureus subsp. aureus MRSA252 3-oxoacyl-ACP reductase YP_040618.1 1256711 D 282458 CDS YP_040619.1 49483395 2859057 1257757..1257990 1 NC_002952.2 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1257990 acpP 2859057 acpP Staphylococcus aureus subsp. aureus MRSA252 acyl carrier protein YP_040619.1 1257757 D 282458 CDS YP_040620.1 49483396 2860435 1258106..1258837 1 NC_002952.2 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1258837 rnc 2860435 rnc Staphylococcus aureus subsp. aureus MRSA252 ribonuclease III YP_040620.1 1258106 D 282458 CDS YP_040621.1 49483397 2860436 1258984..1262550 1 NC_002952.2 Similar to Bacillus subtilis chromosome partition protein Smc SW:SMC_BACSU (P51834) (1186 aa) fasta scores: E(): 5.6e-123, 42.366% id in 1192 aa, and to Gallus gallus chromosome scaffold protein SciI SW:SCII_CHICK (Q90988) (1189 aa) fasta scores: E(): 7.6e-41, 23.977% id in 1197 aa. CDS contains several coiled-coiled domains, between residues 246 to 470 and 687 to 903; chromosome partition protein 1262550 2860436 SAR1210 Staphylococcus aureus subsp. aureus MRSA252 chromosome partition protein YP_040621.1 1258984 D 282458 CDS YP_040622.1 49483398 2860437 1262550..1263800 1 NC_002952.2 Internal region is similar to Bacillus subtilis cell division protein FtsY homologue Srb SW:FTSY_BACSU (P51835) (329 aa) fasta scores: E(): 8e-71, 69.470% id in 321 aa. Similar to the C-terminal region of Escherichia coli cell division protein FtsY SW:FTSY_ECOLI (P10121) (497 aa) fasta scores: E(): 6.7e-45, 44.063% id in 379 aa; cell division protein 1263800 2860437 SAR1211 Staphylococcus aureus subsp. aureus MRSA252 cell division protein YP_040622.1 1262550 D 282458 CDS YP_040623.1 49483399 2860438 1263787..1264119 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2485 TR:Q9KA09 (EMBL:AP001515) (109 aa) fasta scores: E(): 2e-16, 57.143% id in 105 aa, and to Bacillus subtilis hypothetical protein YlxM SW:YLXM_BACSU (P37104) (110 aa) fasta scores: E(): 5.2e-16, 54.630% id in 108 aa; DNA-binding protein 1264119 2860438 SAR1212 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_040623.1 1263787 D 282458 CDS YP_040624.1 49483400 2860662 1264145..1265512 1 NC_002952.2 Similar to Bacillus subtilis signal recognition particle protein Ffh SW:SR54_BACSU (P37105) (446 aa) fasta scores: E(): 8.5e-105, 70.110% id in 455 aa, and to Escherichia coli, and signal recognition particle protein Ffh TR:AAG57721 (EMBL:X01818) (453 aa) fasta scores: E(): 9.5e-74, 51.214% id in 453 aa; signal recognition particle protein 1265512 ffh 2860662 ffh Staphylococcus aureus subsp. aureus MRSA252 signal recognition particle protein YP_040624.1 1264145 D 282458 CDS YP_040625.1 49483401 2861452 1265947..1266222 1 NC_002952.2 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 1266222 rpsP 2861452 rpsP Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S16 YP_040625.1 1265947 D 282458 CDS YP_040626.1 49483402 2859271 1266410..1266913 1 NC_002952.2 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 1266913 rimM 2859271 rimM Staphylococcus aureus subsp. aureus MRSA252 16S rRNA-processing protein RimM YP_040626.1 1266410 D 282458 CDS YP_040627.1 49483403 2860396 1266913..1267650 1 NC_002952.2 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 1267650 trmD 2860396 trmD Staphylococcus aureus subsp. aureus MRSA252 tRNA (guanine-N(1)-)-methyltransferase YP_040627.1 1266913 D 282458 CDS YP_040628.1 49483404 2860914 1267753..1268103 1 NC_002952.2 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1268103 rplS 2860914 rplS Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L19 YP_040628.1 1267753 D 282458 CDS YP_040629.1 49483405 2860439 complement(1268347..1270953) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfhO TR:O31582 (EMBL:Z99108) (819 aa) fasta scores: E(): 1.7e-57, 28.193% id in 830 aa, and to Streptococcus pyogenes hypothetical protein SPY2211 TR:Q99XH1 (EMBL:AE006638) (858 aa) fasta scores: E(): 7.2e-05, 20.465% id in 904 aa. CDS extended at the N-terminus in comparison to the B. subtilis protein; hypothetical protein 1270953 2860439 SAR1218 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040629.1 1268347 R 282458 CDS YP_040630.1 49483406 2860440 1271354..1272238 1 NC_002952.2 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1272238 rbgA 2860440 rbgA Staphylococcus aureus subsp. aureus MRSA252 ribosomal biogenesis GTPase YP_040630.1 1271354 D 282458 CDS YP_040631.1 49483407 2859276 1272222..1272989 1 NC_002952.2 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1272989 rnhB 2859276 rnhB Staphylococcus aureus subsp. aureus MRSA252 ribonuclease HII YP_040631.1 1272222 D 282458 CDS YP_040632.1 49483408 2860441 1273098..1274264 1 NC_002952.2 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1274264 sucC 2860441 sucC Staphylococcus aureus subsp. aureus MRSA252 succinyl-CoA synthetase subunit beta YP_040632.1 1273098 D 282458 CDS YP_040633.1 49483409 2860442 1274286..1275194 1 NC_002952.2 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 1275194 2860442 SAR1222 Staphylococcus aureus subsp. aureus MRSA252 succinyl-CoA synthetase subunit alpha YP_040633.1 1274286 D 282458 CDS YP_040634.1 49483410 2859817 1275421..1276539 1 NC_002952.2 Similar to Staphylococcus aureus cell wall hydrolase LytN TR:Q9ZNI1 (EMBL:AB015195) (383 aa) fasta scores: E(): 7.4e-138, 96.345% id in 383 aa. C-terminus is similar to the N-terminal region of bacteriophage phi ETA Orf65 TR:Q9FZY0 (EMBL:AP001553) (470 aa) fasta scores: E(): 1.4e-19, 45.714% id in 140 aa; cell wall hydrolase 1276539 lytN 2859817 lytN Staphylococcus aureus subsp. aureus MRSA252 cell wall hydrolase YP_040634.1 1275421 D 282458 CDS YP_040635.1 49483411 2860670 1276567..1277811 1 NC_002952.2 Similar to Staphylococcus simulans lysostaphin immunity factor Lif TR:O05989 (EMBL:U66883) (413 aa) fasta scores: E(): 1.3e-89, 56.174% id in 413 aa, and to Staphylococcus aureus hypothetical protein FmhC TR:Q9S685 (EMBL:AF106851) (414 aa) fasta scores: E(): 1.3e-153, 99.275% id in 414 aa. Similar to SAR2501, 60.934% identity (60.934% ungapped) in 407 aa overlap; FemAB family protein 1277811 fmhC 2860670 fmhC Staphylococcus aureus subsp. aureus MRSA252 FemAB family protein YP_040635.1 1276567 D 282458 CDS YP_040636.1 49483412 2860443 1277983..1278855 1 NC_002952.2 Similar to Bacillus halodurans DNA processing protein BH2468 TR:Q9KA22 (EMBL:AP001515) (302 aa) fasta scores: E(): 4.1e-29, 41.880% id in 234 aa, and to Bacillus subtilis DNA processing Smf protein homologue SW:SMF_BACSU (P39813) (297 aa) fasta scores: E(): 8.5e-29, 40.455% id in 220 aa; SMF family protein 1278855 2860443 SAR1225 Staphylococcus aureus subsp. aureus MRSA252 SMF family protein YP_040636.1 1277983 D 282458 CDS YP_040637.1 49483413 2860393 1279035..1281104 1 NC_002952.2 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1281104 topA 2860393 topA Staphylococcus aureus subsp. aureus MRSA252 DNA topoisomerase I YP_040637.1 1279035 D 282458 CDS YP_040638.1 49483414 2860444 1281260..1282567 1 NC_002952.2 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 1282567 2860444 SAR1227 Staphylococcus aureus subsp. aureus MRSA252 tRNA (uracil-5-)-methyltransferase Gid YP_040638.1 1281260 D 282458 CDS YP_040639.1 49483415 2860445 1282985..1283881 1 NC_002952.2 Similar to Escherichia coli integrase/recombinase XerD SW:XERD_ECOLI (P21891) (298 aa) fasta scores: E(): 8.1e-32, 39.175% id in 291 aa, and to Bacillus subtilis probable integrase/recombinase CodV SW:CODV_BACSU (P39776) (304 aa) fasta scores: E(): 4.4e-47, 45.485% id in 299 aa; integrase/recombinase 1283881 2860445 SAR1228 Staphylococcus aureus subsp. aureus MRSA252 integrase/recombinase YP_040639.1 1282985 D 282458 CDS YP_040640.1 49483416 2859648 1283878..1284423 1 NC_002952.2 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 1284423 hslV 2859648 hslV Staphylococcus aureus subsp. aureus MRSA252 ATP-dependent protease peptidase subunit YP_040640.1 1283878 D 282458 CDS YP_040641.1 49483417 2860446 1284489..1285892 1 NC_002952.2 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 1285892 hslU 2860446 hslU Staphylococcus aureus subsp. aureus MRSA252 ATP-dependent protease ATP-binding subunit HslU YP_040641.1 1284489 D 282458 CDS YP_040642.1 49483418 2859242 1285917..1286690 1 NC_002952.2 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 1286690 codY 2859242 codY Staphylococcus aureus subsp. aureus MRSA252 transcriptional repressor CodY YP_040642.1 1285917 D 282458 CDS YP_040643.1 49483419 2860173 1287032..1287799 1 NC_002952.2 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1287799 rpsB 2860173 rpsB Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S2 YP_040643.1 1287032 D 282458 CDS YP_040644.1 49483420 2860407 1287981..1288862 1 NC_002952.2 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1288862 tsf 2860407 tsf Staphylococcus aureus subsp. aureus MRSA252 elongation factor Ts YP_040644.1 1287981 D 282458 CDS YP_040645.1 49483421 2859289 1288999..1289721 1 NC_002952.2 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1289721 pyrH 2859289 pyrH Staphylococcus aureus subsp. aureus MRSA252 uridylate kinase YP_040645.1 1288999 D 282458 CDS YP_040646.1 49483422 2860681 1289740..1290294 1 NC_002952.2 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 1290294 frr 2860681 frr Staphylococcus aureus subsp. aureus MRSA252 ribosome recycling factor YP_040646.1 1289740 D 282458 CDS YP_040647.1 49483423 2860415 1290667..1291437 1 NC_002952.2 catalyzes the formation of UDP pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 1291437 uppS 2860415 uppS Staphylococcus aureus subsp. aureus MRSA252 UDP pyrophosphate synthase YP_040647.1 1290667 D 282458 CDS YP_040648.1 49483424 2860447 1291444..1292226 1 NC_002952.2 Similar to Escherichia coli phosphatidate cytidylyltransferase CdsA SW:CDSA_ECOLI (P06466) (249 aa) fasta scores: E(): 2.7e-18, 35.455% id in 220 aa, and to Bacillus subtilis phosphatidate cytidylyltransferase CdsA SW:CDSA_BACSU (O31752) (269 aa) fasta scores: E(): 3.7e-40, 46.565% id in 262 aa; phosphatidate cytidylyltransferase 1292226 2860447 SAR1237 Staphylococcus aureus subsp. aureus MRSA252 phosphatidate cytidylyltransferase YP_040648.1 1291444 D 282458 CDS YP_040649.1 49483425 2860448 1292438..1293724 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YluC TR:O31754 (EMBL:Z99112) (422 aa) fasta scores: E(): 1.4e-64, 42.494% id in 433 aa, and to Bacillus halodurans hypothetical protein BH2420 TR:Q9KA70 (EMBL:AP001515) (420 aa) fasta scores: E(): 1.7e-58, 40.326% id in 429 aa; hypothetical protein 1293724 2860448 SAR1238 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040649.1 1292438 D 282458 CDS YP_040650.1 49483426 2860153 1293744..1295447 1 NC_002952.2 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1295447 proS 2860153 proS Staphylococcus aureus subsp. aureus MRSA252 prolyl-tRNA synthetase YP_040650.1 1293744 D 282458 CDS YP_040651.1 49483427 2861012 1295705..1300021 1 NC_002952.2 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 1300021 polC 2861012 polC Staphylococcus aureus subsp. aureus MRSA252 DNA polymerase III PolC YP_040651.1 1295705 D 282458 CDS YP_040652.1 49483428 2860449 1300311..1300778 1 NC_002952.2 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 1300778 2860449 SAR1241 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040652.1 1300311 D 282458 CDS YP_040653.1 49483429 2859171 1300799..1301974 1 NC_002952.2 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1301974 nusA 2859171 nusA Staphylococcus aureus subsp. aureus MRSA252 transcription elongation factor NusA YP_040653.1 1300799 D 282458 CDS YP_040654.1 49483430 2860450 1301995..1302279 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2415 TR:Q9KA75 (EMBL:AP001515) (91 aa) fasta scores: E(): 7.4e-11, 46.988% id in 83 aa, and to Bacillus subtilis hypothetical protein YlxR SW:YLXR_BACSU (P32728) (91 aa) fasta scores: E(): 7.4e-11, 45.161% id in 93 aa; hypothetical protein 1302279 2860450 SAR1243 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040654.1 1301995 D 282458 CDS YP_040655.1 49483431 2860451 1302276..1302593 1 NC_002952.2 Similar to Gallus gallus 60S ribosomal protein L30 SW:RL30_CHICK (P47833) (114 aa) fasta scores: E(): 0.0062, 33.333% id in 102 aa, and to Bacillus subtilis probable ribosomal protein YlxQ SW:YLXQ_BACSU (P32729) (100 aa) fasta scores: E(): 5.6e-15, 50.000% id in 100 aa; ribosomal protein 1302593 2860451 SAR1244 Staphylococcus aureus subsp. aureus MRSA252 ribosomal protein YP_040655.1 1302276 D 282458 CDS YP_040656.1 49483432 2859668 1302598..1304715 1 NC_002952.2 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1304715 infB 2859668 infB Staphylococcus aureus subsp. aureus MRSA252 translation initiation factor IF-2 YP_040656.1 1302598 D 282458 CDS YP_040657.1 49483433 2859299 1305102..1305452 1 NC_002952.2 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 1305452 rbfA 2859299 rbfA Staphylococcus aureus subsp. aureus MRSA252 ribosome-binding factor A YP_040657.1 1305102 D 282458 CDS YP_040658.1 49483434 2860452 1305622..1306539 1 NC_002952.2 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1306539 2860452 SAR1247 Staphylococcus aureus subsp. aureus MRSA252 tRNA pseudouridine synthase B YP_040658.1 1305622 D 282458 CDS YP_040659.1 49483435 2860005 1306554..1307525 1 NC_002952.2 Similar to Bacillus subtilis riboflavin biosynthesis protein RibC [includes: riboflavin kinase, FMN adenylyltransferase] RibC SW:RIBC_BACSU (P54575) (316 aa) fasta scores: E(): 8.9e-46, 44.660% id in 309 aa, and to Bacillus halodurans riboflavin biosynthesis protein BH2409 TR:Q9KA81 (EMBL:AP001515) (313 aa) fasta scores: E(): 3.4e-43, 42.903% id in 310 aa; riboflavin biosynthesis protein 1307525 2860005 SAR1248 Staphylococcus aureus subsp. aureus MRSA252 riboflavin biosynthesis protein YP_040659.1 1306554 D 282458 CDS YP_040660.1 49483436 2861451 1307640..1307909 1 NC_002952.2 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1307909 rpsO 2861451 rpsO Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S15 YP_040660.1 1307640 D 282458 CDS YP_040661.1 49483437 2859910 1308278..1310374 1 NC_002952.2 Similar to Bacillus subtilis polyribonucleotide nucleotidyltransferase PnpA SW:PNP_BACSU (P50849) (704 aa) fasta scores: E(): 4.3e-165, 68.012% id in 694 aa, and to Bacillus halodurans polynucleotide phosphorylase BH2407 TR:Q9KA83 (EMBL:AP001515) (704 aa) fasta scores: E(): 4.1e-163, 66.523% id in 696 aa; polynucleotide phosphorylase/polyadenylase 1310374 pnpA 2859910 pnpA Staphylococcus aureus subsp. aureus MRSA252 polynucleotide phosphorylase/polyadenylase YP_040661.1 1308278 D 282458 CDS YP_040662.1 49483438 2860006 1310610..1312283 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2398 TR:Q9KA92 (EMBL:AP001515) (555 aa) fasta scores: E(): 1.1e-106, 50.090% id in 555 aa, and to Bacillus subtilis hypothetical protein YmfA TR:O31760 (EMBL:Z99112) (515 aa) fasta scores: E(): 7.4e-100, 49.320% id in 515 aa; hypothetical protein 1312283 2860006 SAR1251 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040662.1 1310610 D 282458 CDS YP_040663.1 49483439 2860007 1312540..1314909 1 NC_002952.2 Similar to Bacillus subtilis stage III sporulation protein E SpoIIIE SW:SP3E_BACSU (P21458) (787 aa) fasta scores: E(): 4.6e-110, 48.111% id in 794 aa, and to Bacillus halodurans SpoIIIE protein BH2395 TR:Q9KA95 (EMBL:AP001515) (789 aa) fasta scores: E(): 2.1e-110, 47.975% id in 790 aa; DNA translocase (FtsK/SpoIIIE family protein) 1314909 2860007 SAR1252 Staphylococcus aureus subsp. aureus MRSA252 DNA translocase (FtsK/SpoIIIE family protein) YP_040663.1 1312540 D 282458 CDS YP_040664.1 49483440 2860008 1314914..1315627 1 NC_002952.2 Similar to Bacillus subtilis hypothetical transcriptional regulator YmfC SW:YMFC_BACSU (O31761) (241 aa) fasta scores: E(): 2.9e-21, 34.335% id in 233 aa, and to Bacillus halodurans transcriptional regulator BH2394 TR:Q9KA96 (EMBL:AP001515) (242 aa) fasta scores: E(): 6.5e-20, 35.681% id in 213 aa; hypothetical protein 1315627 2860008 SAR1253 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040664.1 1314914 D 282458 CDS YP_040665.1 49483441 2860009 1315658..1316923 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2393 TR:Q9KA97 (EMBL:AP001515) (431 aa) fasta scores: E(): 2.3e-44, 34.211% id in 418 aa, and to Lactococcus lactis protease YueF TR:Q9CE72 (EMBL:AE006427) (418 aa) fasta scores: E(): 1.5e-32, 30.542% id in 406 aa; hypothetical protein 1316923 2860009 SAR1254 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040665.1 1315658 D 282458 CDS YP_040666.1 49483442 2860010 1316923..1318209 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YmfH TR:O31766 (EMBL:Z99112) (415 aa) fasta scores: E(): 1.1e-67, 46.530% id in 389 aa, and to Bacillus halodurans hypothetical protein BH2392 TR:Q9KA98 (EMBL:AP001515) (432 aa) fasta scores: E(): 2.5e-64, 42.298% id in 409 aa; protease 1318209 2860010 SAR1255 Staphylococcus aureus subsp. aureus MRSA252 protease YP_040666.1 1316923 D 282458 CDS YP_040667.1 49483443 2860011 1318209..1318913 1 NC_002952.2 Similar to Alcaligenes eutrophus acetoacetyl-CoA reductase PhbB SW:PHBB_ALCEU (P14697) (246 aa) fasta scores: E(): 1.9e-16, 31.120% id in 241 aa, and to Bacillus halodurans 3-oxoacyl-[acyl carrier protein] reductase BH2391 TR:Q9KA99 (EMBL:AP001515) (242 aa) fasta scores: E(): 8.1e-24, 35.021% id in 237 aa; short chain dehydrogenase 1318913 2860011 SAR1256 Staphylococcus aureus subsp. aureus MRSA252 short chain dehydrogenase YP_040667.1 1318209 D 282458 CDS YP_040668.1 49483444 2860012 1319018..1319845 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2389 TR:Q9KAA1 (EMBL:AP001515) (257 aa) fasta scores: E(): 9.6e-57, 61.983% id in 242 aa. Internal region is similar to Bacillus subtilis hypothetical protein TR:P94509 (EMBL:U87792) (158 aa) fasta scores: E(): 5.8e-35, 70.290% id in 138 aa; hypothetical protein 1319845 2860012 SAR1257 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040668.1 1319018 D 282458 CDS YP_040669.1 49483445 2860013 1319864..1320256 1 NC_002952.2 Similar to the N-terminal regions of Bacillus subtilis hypothetical protein TR:P94510 (EMBL:U87792) (307 aa) fasta scores: E(): 2e-05, 31.200% id in 125 aa, and Bacillus halodurans hypothetical protein BH2388 TR:Q9KAA2 (EMBL:AP001515) (283 aa) fasta scores: E(): 0.0014, 29.825% id in 114 aa; DNA-binding protein 1320256 2860013 SAR1258 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_040669.1 1319864 D 282458 CDS YP_040670.1 49483446 2859901 1320290..1320868 1 NC_002952.2 Similar to Bacillus subtilis CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA SW:PGSA_BACSU (P46322) (193 aa) fasta scores: E(): 5.4e-28, 48.677% id in 189 aa, and to Bacillus halodurans phosphatidylglycerophosphate synthase BH2386 TR:Q9KAA4 (EMBL:AP001515) (192 aa) fasta scores: E(): 1.7e-28, 50.000% id in 194 aa; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1320868 pgsA 2859901 pgsA Staphylococcus aureus subsp. aureus MRSA252 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_040670.1 1320290 D 282458 CDS YP_040671.1 49483447 2859065 1321093..1322244 1 NC_002952.2 Similar to Bacillus subtilis CinA-like protein CinA SW:CINA_BACSU (P46323) (416 aa) fasta scores: E(): 2e-44, 41.133% id in 406 aa, and to Bacillus halodurans competence-damage inducible protein BH2385 TR:Q9KAA5 (EMBL:AP001515) (420 aa) fasta scores: E(): 3.5e-43, 39.518% id in 415 aa; hypothetical protein 1322244 2859065 SAR1260 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040671.1 1321093 D 282458 CDS YP_040672.1 49483448 2859300 1322409..1323452 1 NC_002952.2 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1323452 recA 2859300 recA Staphylococcus aureus subsp. aureus MRSA252 recombinase A YP_040672.1 1322409 D 282458 CDS YP_040673.1 49483449 2859066 1323806..1325365 1 NC_002952.2 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP; phosphodiesterase 1325365 2859066 SAR1262 Staphylococcus aureus subsp. aureus MRSA252 phosphodiesterase YP_040673.1 1323806 D 282458 CDS YP_040674.1 49483450 2859067 complement(1325661..1325831) 1 NC_002952.2 hypothetical protein 1325831 2859067 SAR1263 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040674.1 1325661 R 282458 CDS YP_040675.1 49483451 2859068 1326050..1326847 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YmdB TR:O31775 (EMBL:Z99112) (264 aa) fasta scores: E(): 5.4e-66, 65.019% id in 263 aa, and to Bacillus halodurans hypothetical protein BH2376 TR:Q9KAB3 (EMBL:AP001515) (264 aa) fasta scores: E(): 4.2e-59, 58.555% id in 263 aa; hypothetical protein 1326847 2859068 SAR1264 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040675.1 1326050 D 282458 CDS YP_040676.1 49483452 2859069 1326987..1328747 1 NC_002952.2 Similar to Bacillus halodurans pyruvate synthase alpha subunit BH2374 TR:Q9KAB5 (EMBL:AP001515) (579 aa) fasta scores: E(): 1.4e-137, 63.903% id in 579 aa, and to Halobacterium sp pyruvate ferredoxin oxidoreductase alpha subunit VNG0474G TR:Q9HRZ5 (EMBL:AE005001) (582 aa) fasta scores: E(): 9.2e-80, 39.619% id in 578 aa; pyruvate flavodoxin/ferredoxin oxidoreductase 1328747 2859069 SAR1265 Staphylococcus aureus subsp. aureus MRSA252 pyruvate flavodoxin/ferredoxin oxidoreductase YP_040676.1 1326987 D 282458 CDS YP_040677.1 49483453 2859070 1328748..1329614 1 NC_002952.2 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta 1329614 2859070 SAR1266 Staphylococcus aureus subsp. aureus MRSA252 2-oxoglutarate ferredoxin oxidoreductase subunit beta YP_040677.1 1328748 D 282458 CDS YP_040678.1 49483454 2859071 1329709..1330002 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3874 TR:Q9K658 (EMBL:AP001520) (92 aa) fasta scores: E(): 6.3e-07, 30.769% id in 91 aa, and to Clostridium perfringens hypothetical protein SW:YVI2_CLOPE (Q46213) (95 aa) fasta scores: E(): 1.1e-05, 32.222% id in 90 aa; hypothetical protein 1330002 2859071 SAR1267 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040678.1 1329709 D 282458 CDS YP_040679.1 49483455 2859072 1330136..1331680 1 NC_002952.2 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 1331680 2859072 SAR1268 Staphylococcus aureus subsp. aureus MRSA252 (dimethylallyl)adenosine tRNA methylthiotransferase YP_040679.1 1330136 D 282458 CDS YP_040680.1 49483456 2859073 1331681..1332046 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YmcA TR:O31779 (EMBL:Z99112) (143 aa) fasta scores: E(): 6.3e-10, 33.628% id in 113 aa, and to Bacillus halodurans hypothetical protein BH2371 TR:Q9KAB8 (EMBL:AP001515) (146 aa) fasta scores: E(): 3.2e-09, 32.743% id in 113 aa; hypothetical protein 1332046 2859073 SAR1269 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040680.1 1331681 D 282458 CDS YP_040681.1 49483457 2859074 1332073..1332564 1 NC_002952.2 Similar to Pyrococcus horikoshii hypothetical protein PH0159 SW:Y159_PYRHO (O57898) (162 aa) fasta scores: E(): 0.21, 29.114% id in 158 aa, and to Aeropyrum pernix hypothetical protein APE2411 TR:Q9Y974 (EMBL:AP000064) (197 aa) fasta scores: E(): 1.7e-09, 33.537% id in 164 aa; hypothetical protein 1332564 2859074 SAR1270 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040681.1 1332073 D 282458 CDS YP_040682.1 49483458 2861327 1332867..1335485 1 NC_002952.2 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1335485 mutS 2861327 mutS Staphylococcus aureus subsp. aureus MRSA252 DNA mismatch repair protein MutS YP_040682.1 1332867 D 282458 CDS YP_040683.1 49483459 2861326 1335498..1337507 1 NC_002952.2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 1337507 mutL 2861326 mutL Staphylococcus aureus subsp. aureus MRSA252 DNA mismatch repair protein YP_040683.1 1335498 D 282458 CDS YP_040684.1 49483460 2859927 1337522..1338055 1 NC_002952.2 Similar to Bacillus subtilis glycerol uptake operon antiterminator regulatory protein GlpP SW:GLPP_BACSU (P30300) (192 aa) fasta scores: E(): 3.1e-26, 42.614% id in 176 aa, and to Bacillus halodurans transcriptional antiterminator of glycerol uptake operon BH1091 TR:Q9KDX0 (EMBL:AP001510) (183 aa) fasta scores: E(): 7e-26, 43.503% id in 177 aa; glycerol uptake operon antiterminator regulatory protein 1338055 glpP 2859927 glpP Staphylococcus aureus subsp. aureus MRSA252 glycerol uptake operon antiterminator regulatory protein YP_040684.1 1337522 D 282458 CDS YP_040685.1 49483461 2861361 complement(1338092..1338190) 1 NC_002952.2 Doubtful CDS. No significant database hits; hypothetical protein 1338190 2861361 SAR1273a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040685.1 1338092 R 282458 CDS YP_040686.1 49483462 2859925 1338530..1339348 1 NC_002952.2 Similar to Bacillus subtilis glycerol uptake facilitator protein GlpF SW:GLPF_BACSU (P18156) (274 aa) fasta scores: E(): 3.2e-55, 59.542% id in 262 aa, and to Bacillus halodurans glycerol uptake facilitator BH1092 TR:Q9KDW9 (EMBL:AP001510) (276 aa) fasta scores: E(): 1.9e-54, 60.967% id in 269 aa; glycerol uptake facilitator protein 1339348 glpF 2859925 glpF Staphylococcus aureus subsp. aureus MRSA252 glycerol uptake facilitator protein YP_040686.1 1338530 D 282458 CDS YP_040687.1 49483463 2859926 1339478..1340974 1 NC_002952.2 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 1340974 glpK 2859926 glpK Staphylococcus aureus subsp. aureus MRSA252 glycerol kinase YP_040687.1 1339478 D 282458 CDS YP_040688.1 49483464 2859924 1341084..1342805 1 NC_002952.2 Similar to Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase GlpD SW:GLPD_BACSU (P18158) (555 aa) fasta scores: E(): 6.8e-126, 61.538% id in 546 aa, and to Bacillus halodurans glycerol-3-phosphate dehydrogenase BH1095 TR:Q9KDW6 (EMBL:AP001510) (553 aa) fasta scores: E(): 1.2e-114, 56.960% id in 546 aa. Possible alternative translational start site; aerobic glycerol-3-phosphate dehydrogenase 1342805 glpD 2859924 glpD Staphylococcus aureus subsp. aureus MRSA252 aerobic glycerol-3-phosphate dehydrogenase YP_040688.1 1341084 D 282458 CDS YP_040689.1 49483465 2861362 1342955..1343869 1 NC_002952.2 Similar to Pseudomonas aeruginosa hypothetical protein PA3301 TR:Q9HYU2 (EMBL:AE004752) (316 aa) fasta scores: E(): 1.6e-25, 30.519% id in 308 aa, and to Rhizobium loti hypothetical protein MLR1612 TR:BAB48946 (EMBL:AP002997) (309 aa) fasta scores: E(): 6.4e-19, 26.871% id in 294 aa; hydrolase 1343869 2861362 SAR1277 Staphylococcus aureus subsp. aureus MRSA252 hydrolase YP_040689.1 1342955 D 282458 CDS YP_040690.1 49483466 2861164 1343887..1344822 1 NC_002952.2 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 1344822 miaA 2861164 miaA Staphylococcus aureus subsp. aureus MRSA252 tRNA delta(2)-isopentenylpyrophosphate transferase YP_040690.1 1343887 D 282458 CDS YP_040691.1 49483467 2861363 1344837..1345070 1 NC_002952.2 Similar to Escherichia coli host factor-I for bacteriophage Q beta replication, Hfq TR:BAB38571 (EMBL:D00743) (102 aa) fasta scores: E(): 0.00013, 33.871% id in 62 aa, and to Bacillus halodurans host factor-1 protein BH2365 TR:Q9KAC4 (EMBL:AP001515) (78 aa) fasta scores: E(): 9.6e-11, 44.737% id in 76 aa; hypothetical protein 1345070 2861363 SAR1279 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040691.1 1344837 D 282458 CDS YP_040692.1 49483468 2861364 complement(1345292..1345768) 1 NC_002952.2 Similar to Hordeum vulgare glutathione peroxidase TR:Q9SME4 (EMBL:AJ238745) (165 aa) fasta scores: E(): 2.8e-31, 50.955% id in 157 aa, and to Bacillus halodurans glutathione peroxidase homologue BH2830 SW:BSAA_BACHD (Q9Z9N7) (157 aa) fasta scores: E(): 5.1e-34, 57.051% id in 156 aa. Similar to SAR2699, 50.323% identity (50.323% ungapped) in 155 aa overlap; glutathione peroxidase 1345768 2861364 SAR1280 Staphylococcus aureus subsp. aureus MRSA252 glutathione peroxidase YP_040692.1 1345292 R 282458 CDS YP_040693.1 49483469 2861365 1345880..1347118 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2362 TR:Q9KAC7 (EMBL:AP001515) (418 aa) fasta scores: E(): 2.6e-62, 46.287% id in 404 aa, and to Streptococcus pyogenes GTP-binding protein SPY0922 TR:Q9A058 (EMBL:AE006541) (412 aa) fasta scores: E(): 6.1e-60, 44.975% id in 398 aa; hypothetical protein 1347118 2861365 SAR1281 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040693.1 1345880 D 282458 CDS YP_040694.1 49483470 2861366 1347137..1348375 1 NC_002952.2 Similar to Arthrobacter viscosus aluminum resistance protein Alu-2 TR:O52647 (EMBL:AF043609) (422 aa) fasta scores: E(): 8.9e-93, 59.512% id in 410 aa, and to Bacillus subtilis hypothetical protein YnbB TR:P94479 (EMBL:U66480) (421 aa) fasta scores: E(): 7.2e-92, 60.827% id in 411 aa; hypothetical protein 1348375 2861366 SAR1282 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040694.1 1347137 D 282458 CDS YP_040695.1 49483471 2859923 1348619..1348987 1 NC_002952.2 Previously sequenced as Staphylococcus aureus glutamine synthetase repressor GlnR TR:Q53687 (EMBL:X76490) (122 aa) fasta scores: E(): 5.8e-42, 100.000% id in 122 aa. Similar to Streptococcus pyogenes transcriptional regulator SPY1878 TR:Q99Y40 (EMBL:AE006613) (123 aa) fasta scores: E(): 2.3e-12, 50.000% id in 100 aa; glutamine synthetase 1348987 glnR 2859923 glnR Staphylococcus aureus subsp. aureus MRSA252 glutamine synthetase YP_040695.1 1348619 D 282458 CDS YP_040696.1 49483472 2859921 1349006..1350346 1 NC_002952.2 Previously sequenced as Staphylococcus aureus glutamine synthetase GlnA SW:GLNA_STAAU (Q59812) (446 aa) fasta scores: E(): 1.8e-181, 99.776% id in 446 aa. Similar to Bacillus subtilis glutamine synthetase GlnA SW:GLNA_BACSU (P12425) (443 aa) fasta scores: E(): 4.2e-141, 76.190% id in 441 aa; glutamine synthetase 1350346 glnA 2859921 glnA Staphylococcus aureus subsp. aureus MRSA252 glutamine synthetase YP_040696.1 1349006 D 282458 CDS YP_040697.1 49483473 2861367 1350840..1351037 1 NC_002952.2 Similar to the N-terminal region of Streptococcus thermophilus temperate bacteriophage phi O1205 hypothetical protein Orf57 TR:O34088 (EMBL:U88974) (140 aa) fasta scores: E(): 3.4, 37.500% id in 48 aa. Probable gene remnant. Similar to SAR1302, 51.562% identity (51.562% ungapped) in 64 aa overlap; hypothetical protein 1351037 2861367 SAR1285 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040697.1 1350840 D 282458 CDS YP_040698.1 49483474 2861369 complement(1352458..1352814) 1 NC_002952.2 Poor database matches. Similar to hypothetical protein Bacillus subtilis YddJ TR:P96647 (EMBL:AB001488) (126 aa) fasta scores: E(): 0.027, 28.689% id in 122 aa; lipoprotein 1352814 2861369 SAR1288 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_040698.1 1352458 R 282458 CDS YP_040699.1 49483475 2861370 complement(1352870..1353460) 1 NC_002952.2 hypothetical protein 1353460 2861370 SAR1289 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040699.1 1352870 R 282458 CDS YP_040700.1 49483476 2861371 complement(1353467..1354453) 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus conjugative plasmid pSK41 membrane protein TraG TR:Q52271 (EMBL:AF051917) (358 aa) fasta scores: E(): 3.7e-50, 44.828% id in 348 aa; hypothetical protein 1354453 2861371 SAR1290 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040700.1 1353467 R 282458 CDS YP_040701.1 49483477 2861372 complement(1354503..1356350) 1 NC_002952.2 Similar to Enterococcus faecalis hypothetical protein EP0024 TR:Q9F1H1 (EMBL:AE002565) (781 aa) fasta scores: E(): 1.7e-08, 22.727% id in 660 aa, and to Bacillus subtilis hypothetical protein YddG TR:P96644 (EMBL:AB001488) (815 aa) fasta scores: E(): 1.3e-06, 23.680% id in 663 aa; hypothetical protein 1356350 2861372 SAR1291 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040701.1 1354503 R 282458 CDS YP_040702.1 49483478 2861373 complement(1356355..1357713) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdcQ TR:P96634 (EMBL:AB001488) (480 aa) fasta scores: E(): 2.3e-38, 32.379% id in 454 aa, and to Enterococcus faecalis conjugative transposon Tn916 hypothetical protein Orf21 TR:Q47727 (EMBL:U09422) (461 aa) fasta scores: E(): 1.2e-32, 30.283% id in 459 aa; FtsK/SpoIIIE family protein 1357713 2861373 SAR1292 Staphylococcus aureus subsp. aureus MRSA252 FtsK/SpoIIIE family protein YP_040702.1 1356355 R 282458 CDS YP_040703.1 49483479 2861374 complement(1357767..1360262) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YddE TR:P96642 (EMBL:AB001488) (831 aa) fasta scores: E(): 1.7e-121, 39.136% id in 833 aa, and to Enterococcus faecalis conjugative transposon Tn916 hypothetical protein Orf16 TR:Q47732 (EMBL:U09422) (815 aa) fasta scores: E(): 2e-17, 23.967% id in 847 aa; hypothetical protein 1360262 2861374 SAR1293 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040703.1 1357767 R 282458 CDS YP_040704.1 49483480 2861375 complement(1360297..1360680) 1 NC_002952.2 Similar to Enterococcus faecalis conjugative transposon Tn916 hypothetical protein Orf17 TR:Q47731 (EMBL:U09422) (168 aa) fasta scores: E(): 2, 29.703% id in 101 aa, and to the N-terminus of Bacillus subtilis hypothetical protein YddD TR:P96641 (EMBL:AB001488) (174 aa) fasta scores: E(): 0.0018, 20.000% id in 130 aa; hypothetical protein 1360680 2861375 SAR1294 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040704.1 1360297 R 282458 CDS YP_040705.1 49483481 2861376 complement(1360692..1360952) 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YddC TR:P96640 (EMBL:AB001488) (82 aa) fasta scores: E(): 0.013, 34.375% id in 64 aa; hypothetical protein 1360952 2861376 SAR1295 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040705.1 1360692 R 282458 CDS YP_040706.1 49483482 2861377 complement(1360957..1362012) 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis YddB protein yddB TR:O31491 (EMBL:Z99106) (354 aa) fasta scores: E(): 2.5e-18, 29.480% id in 346 aa; hypothetical protein 1362012 2861377 SAR1296 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040706.1 1360957 R 282458 CDS YP_040707.1 49483483 2861378 complement(1362073..1363098) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdcR TR:P96635 (EMBL:AB001488) (352 aa) fasta scores: E(): 5.4e-42, 36.810% id in 326 aa, and to Enterococcus faecalis conjugative transposon Tn916 hypothetical protein Orf20 TR:Q47728 (EMBL:U09422) (329 aa) fasta scores: E(): 1.8e-31, 31.563% id in 339 aa; hypothetical protein 1363098 2861378 SAR1297 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040707.1 1362073 R 282458 CDS YP_040708.1 49483484 2861379 complement(1363340..1363642) 1 NC_002952.2 hypothetical protein 1363642 2861379 SAR1298 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040708.1 1363340 R 282458 CDS YP_040709.1 49483485 2861380 complement(1363656..1363976) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdcP TR:P96633 (EMBL:AB001488) (126 aa) fasta scores: E(): 0.0019, 32.710% id in 107 aa, and to Enterococcus faecalis conjugative transposon Tn916 hypothetical protein Orf22 TR:Q47726 (EMBL:U09422) (128 aa) fasta scores: E(): 0.057, 28.440% id in 109 aa; hypothetical protein 1363976 2861380 SAR1299 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040709.1 1363656 R 282458 CDS YP_040710.1 49483486 2861381 complement(1364127..1364420) 1 NC_002952.2 Poor database matches. Similar to Yersinia pestis plasmid pMT-1 hypothetical protein Y1103 TR:Q9ZGY2 (EMBL:AF074611) (89 aa) fasta scores: E(): 1.8, 29.730% id in 74 aa; hypothetical protein 1364420 2861381 SAR1300 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040710.1 1364127 R 282458 CDS YP_040711.1 49483487 2861382 1365097..1365309 1 NC_002952.2 Poor database matches. Similar to Streptococcus pyogenes hypothetical protein SPY0544 TR:Q9A0Z3 (EMBL:AE006512) (69 aa) fasta scores: E(): 3.9, 33.333% id in 45 aa, and to the N-terminal region of Streptococcus thermophilus bacteriophage Sfi21 hypothetical protein Orf140b TR:O21989 (EMBL:X95646) (140 aa) fasta scores: E(): 0.48, 32.000% id in 50 aa. Similar to SAR1285, 51.562% identity (51.562% ungapped) in 64 aa overlap; hypothetical protein 1365309 2861382 SAR1302 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040711.1 1365097 D 282458 CDS YP_040712.1 49483488 2861383 1365606..1365812 1 NC_002952.2 Similar to the N-terminal regions of Streptococcus thermophilus bacteriophage Sfi21 hypothetical protein Orf140b protein TR:O21989 (EMBL:X95646) (140 aa) fasta scores: E(): 1.3, 29.310% id in 58 aa, and to bacteriophage PM2 hypothetical protein TR:Q9XJS6 (EMBL:AF155037) (92 aa) fasta scores: E(): 2.9, 34.483% id in 29 aa. Similar to SAR1137, 54.545% identity (54.545% ungapped) in 66 aa overlap; hypothetical protein 1365812 2861383 SAR1303 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040712.1 1365606 D 282458 CDS YP_040713.1 49483489 2861384 1367017..1367202 1 NC_002952.2 Similar to Escherichia coli O157:H7 DNA transposition protein ECS4946 TR:BAB38369 (EMBL:AP002567) (310 aa) fasta scores: E(): 0.64, 36.066% id in 61 aa, and to bacteriophage APSE-1 hypothetical protein p2 SW:VP02_BPAPS (Q9T1U6) (94 aa) fasta scores: E(): 4.9, 35.714% id in 56 aa; DNA-binding protein 1367202 2861384 SAR1304 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_040713.1 1367017 D 282458 CDS YP_040714.1 49483490 2861385 complement(1367414..1368361) 1 NC_002952.2 Similar to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 1.4e-126, 99.683% id in 315 aa, and to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 1.5e-70, 58.095% id in 315 aa; transposase 1368361 2861385 SAR1305 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040714.1 1367414 R 282458 CDS YP_040715.1 49483491 2861386 1368788..1369204 1 NC_002952.2 hypothetical protein 1369204 2861386 SAR1306 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040715.1 1368788 D 282458 CDS YP_040716.1 49483492 2861388 1370725..1370976 1 NC_002952.2 hypothetical protein 1370976 2861388 SAR1311 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040716.1 1370725 D 282458 CDS YP_040717.1 49483493 2861389 1371181..1371702 1 NC_002952.2 Poor database matches. Similar to Bacillus anthracis plasmid pXO2 hypothetical protein pXO2-07 TR:Q9RN25 (EMBL:AF188935) (202 aa) fasta scores: E(): 5.5, 28.467% id in 137 aa. N-terminal region is similar to SAR1315, 98.462% identity (98.462% ungapped) in 65 aa overlap, SAR1318, 92.500% identity (92.500% ungapped) in 40 aa overlap, and SAR1324, 81.633% identity (83.333% ungapped) in 49 aa overlap; hypothetical protein 1371702 2861389 SAR1312 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040717.1 1371181 D 282458 CDS YP_040718.1 49483494 2861390 1371704..1371901 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Schizosaccharomyces pombe hypothetical protein SPBC23G7.01c TR:O94752 (EMBL:AL035077) (454 aa) fasta scores: E(): 1.4, 35.938% id in 64 aa. Similar to SAR1317, 50.820% identity (50.820% ungapped) in 61 aa overlap; hypothetical protein 1371901 2861390 SAR1313 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040718.1 1371704 D 282458 CDS YP_040719.1 49483495 2861391 1372328..1372645 1 NC_002952.2 No significant database matches. C-terminal region is similar to SAR1322, 53.125% identity (54.255% ungapped) in 96 aa overlap. N-terminus is similar to C-terminal region of SAR1321, 92.453% identity (92.453% ungapped) in 53 aa overlap. Possible alternative translational start; hypothetical protein 1372645 2861391 SAR1314 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040719.1 1372328 D 282458 CDS YP_040720.1 49483496 2861392 1372972..1373169 1 NC_002952.2 Poor database matches. Similar to internal region of bacteriophage TP901-1 hypothetical protein Orf33 TR:Q9AZ64 (EMBL:AF304433) (564 aa) fasta scores: E(): 0.0027, 35.821% id in 67 aa. Similar to SAR1312, 98.462% identity (98.462% ungapped) in 65 aa overlap, SAR1318, 92.500% identity (92.500% ungapped) in 40 aa overlap, and SAR1324, 81.633% identity (83.333% ungapped) in 49 aa overlap; hypothetical protein 1373169 2861392 SAR1315 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040720.1 1372972 D 282458 CDS YP_040721.1 49483497 2861393 1373314..1373487 1 NC_002952.2 hypothetical protein 1373487 2861393 SAR1316 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040721.1 1373314 D 282458 CDS YP_040722.1 49483498 2861394 1373498..1373692 1 NC_002952.2 No significant database matches. Similar to SAR1313, 50.820% identity (50.820% ungapped) in 61 aa overlap; hypothetical protein 1373692 2861394 SAR1317 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040722.1 1373498 D 282458 CDS YP_040723.1 49483499 2861395 1373905..1374138 1 NC_002952.2 Poor database matches. Similar to an internal region of bacteriophage hypothetical protein TP901-1 Orf33 TR:Q9AZ64 (EMBL:AF304433) (564 aa) fasta scores: E(): 0.017, 35.526% id in 76 aa. Similar to SAR1315, 92.500% identity (92.500% ungapped) in 40 aa overlap, SAR1312, 92.500% identity (92.500% ungapped) in 40 aa overlap, and SAR1324, 83.333% identity (83.333% ungapped) in 42 aa overlap; hypothetical protein 1374138 2861395 SAR1318 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040723.1 1373905 D 282458 CDS YP_040724.1 49483500 2861396 1374311..1374436 1 NC_002952.2 hypothetical protein 1374436 2861396 SAR1319 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040724.1 1374311 D 282458 CDS YP_040725.1 49483501 2861397 1374449..1374697 1 NC_002952.2 hypothetical protein 1374697 2861397 SAR1320 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040725.1 1374449 D 282458 CDS YP_040726.1 49483502 2858928 1374848..1375126 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Mycobacteriophage TM4 hypothetical protein gp8 TR:Q9ZX69 (EMBL:AF068845) (186 aa) fasta scores: E(): 3, 36.250% id in 80 aa; hypothetical protein 1375126 2858928 SAR1321 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040726.1 1374848 D 282458 CDS YP_040727.1 49483503 2858929 1375139..1375438 1 NC_002952.2 Poor database matches. Similar to internal region of Human rotavirus hypothetical protein VP3 TR:Q9IPG6 (EMBL:AB045215) (162 aa) fasta scores: E(): 4.9, 30.667% id in 75 aa. C-terminus is similar to the N-terminal region of SAR1314, 92.453% identity (92.453% ungapped) in 53 aa overlap; hypothetical protein 1375438 2858929 SAR1322 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040727.1 1375139 D 282458 CDS YP_040728.1 49483504 2858930 1375435..1375572 1 NC_002952.2 hypothetical protein 1375572 2858930 SAR1323 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040728.1 1375435 D 282458 CDS YP_040729.1 49483505 2858931 1375775..1375975 1 NC_002952.2 Poor database matches. Similar to C-terminal region of Lactococcus lactis bacteriophage Tuc2009 hypothetical protein TR:Q9AYW9 (EMBL:AF109874) (346 aa) fasta scores: E(): 0.39, 39.216% id in 51 aa. Similar to SAR1315, 81.633% identity (83.333% ungapped) in 49 aa overlap, SAR1318, 83.333% identity (83.333% ungapped) in 42 aa overlap, and to the N-terminal region of SAR1312, 81.633% identity (83.333% ungapped) in 49 aa overlap; hypothetical protein 1375975 2858931 SAR1324 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040729.1 1375775 D 282458 CDS YP_040730.1 49483506 2858932 1375982..1376179 1 NC_002952.2 Poor database matches. Similar to internal region of Ureaplasma parvum hypothetical protein UU376 SW:Y376_UREPA (Q9PQB5) (242 aa) fasta scores: E(): 3.4, 38.095% id in 63 aa; hypothetical protein 1376179 2858932 SAR1325 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040730.1 1375982 D 282458 CDS YP_040731.1 49483507 2858933 1376455..1376565 1 NC_002952.2 hypothetical protein 1376565 2858933 SAR1325b Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040731.1 1376455 D 282458 CDS YP_040732.1 49483508 2858934 complement(1376726..1377751) 1 NC_002952.2 C-terminal region is similar to an internal region of Ashbya gossypii threonine aldolase Gly1 SW:GLY1_ASHGO (O74267) (382 aa) fasta scores: E(): 0.001, 23.183% id in 289 aa. Similar to Leishmania major hypothetical protein L4171.5 l4171.5 TR:O15839 (EMBL:AE001274) (359 aa) fasta scores: E(): 8e-48, 41.888% id in 339 aa; hypothetical protein 1377751 2858934 SAR1326 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040732.1 1376726 R 282458 CDS YP_040733.1 49483509 2858935 1378021..1378218 1 NC_002952.2 hypothetical protein 1378218 2858935 SAR1327 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040733.1 1378021 D 282458 CDS YP_040734.1 49483510 2858936 1378275..1379756 1 NC_002952.2 Similar to Lactococcus lactis cardiolipin synthase ClsB TR:Q9CGC3 (EMBL:AE006349) (487 aa) fasta scores: E(): 4.4e-67, 42.169% id in 498 aa, and to Bacillus subtilis probable cardiolipin synthetase 2 YwnE SW:CLS2_BACSU (P71040) (482 aa) fasta scores: E(): 9.6e-94, 50.000% id in 484 aa. Similar to SAR2177, 55.556% identity (56.144% ungapped) in 477 aa overlap; cardiolipin synthase 1379756 2858936 SAR1328 Staphylococcus aureus subsp. aureus MRSA252 cardiolipin synthase YP_040734.1 1378275 D 282458 CDS YP_040735.1 49483511 2858937 1379930..1380838 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YvfR TR:O07016 (EMBL:Z94043) (301 aa) fasta scores: E(): 3.5e-21, 33.217% id in 286 aa, and to Bacillus licheniformis ABC transporter ATP binding subunit YvfR TR:Q9F5X5 (EMBL:AF302051) (299 aa) fasta scores: E(): 3.2e-17, 28.767% id in 292 aa; ABC transporter ATP-binding protein 1380838 2858937 SAR1329 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040735.1 1379930 D 282458 CDS YP_040736.1 49483512 2858938 1380807..1381538 1 NC_002952.2 Similar to Bacillus cereus hypothetical protein YvfS TR:Q9L4F5 (EMBL:AJ243712) (239 aa) fasta scores: E(): 3.6e-20, 30.802% id in 237 aa, and to Bacillus subtilis hypothetical protein YvfS TR:O07017 (EMBL:Z94043) (245 aa) fasta scores: E(): 3.1e-17, 25.114% id in 219 aa; hypothetical protein 1381538 2858938 SAR1330 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040736.1 1380807 D 282458 CDS YP_040737.1 49483513 2858939 1381542..1382633 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Similar to Salmonella typhimurium sensor protein UhpB SW:UHPB_SALTY (P27668) (500 aa) fasta scores: E(): 7.9e-06, 21.607% id in 361 aa, and to Bacillus cereus two-component sensor histidine kinase YvfT TR:Q9L4F4 (EMBL:AJ243712) (376 aa) fasta scores: E(): 1.5e-21, 29.178% id in 353 aa; sensor kinase 1382633 2858939 SAR1331 Staphylococcus aureus subsp. aureus MRSA252 sensor kinase YP_040737.1 1381542 D 282458 CDS YP_040738.1 49483514 2858940 1382630..1383136 1 NC_002952.2 Possible pseudogene. Two-component regulatory system family, response regulator protein. Similar to Streptococcus pneumoniae response regulator SP2000 TR:Q9S1I7 (EMBL:AJ006400) (199 aa) fasta scores: E(): 1.1e-20, 42.714% id in 199 aa, and to Bacillus halodurans two-component response regulator BH0581 TR:Q9KFA4 (EMBL:AP001509) (201 aa) fasta scores: E(): 7.5e-18, 42.289% id in 201 aa. CDS is smaller than other homologues, contains and internal deletion of approximately 30 amino acids.; response regulator 1383136 2858940 SAR1332 Staphylococcus aureus subsp. aureus MRSA252 response regulator YP_040738.1 1382630 D 282458 CDS YP_040739.1 49483515 2858941 complement(1383249..1383437) 1 NC_002952.2 hypothetical protein 1383437 2858941 SAR1333 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040739.1 1383249 R 282458 CDS YP_040740.1 49483516 2859169 1383576..1384109 1 NC_002952.2 Similar to Staphylococcus intermedius thermonuclease precursor NucI SW:NUC_STAIN (P43269) (168 aa) fasta scores: E(): 7.2e-32, 54.070% id in 172 aa, and to Staphylococcus hyicus thermonuclease precursor NucH SW:NUC_STAHY (P43270) (169 aa) fasta scores: E(): 1.9e-30, 53.672% id in 177 aa; thermonuclease 1384109 nucI 2859169 nucI Staphylococcus aureus subsp. aureus MRSA252 thermonuclease YP_040740.1 1383576 D 282458 CDS YP_040741.1 49483517 2858942 complement(1384252..1385106) 1 NC_002952.2 hypothetical protein 1385106 2858942 SAR1335 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040741.1 1384252 R 282458 CDS YP_040742.1 49483518 2858943 1385422..1386012 1 NC_002952.2 hypothetical protein 1386012 2858943 SAR1336 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040742.1 1385422 D 282458 CDS YP_040743.1 49483519 2858944 complement(1386066..1387460) 1 NC_002952.2 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase 1387460 2858944 SAR1337 Staphylococcus aureus subsp. aureus MRSA252 aspartate kinase YP_040743.1 1386066 R 282458 CDS YP_040744.1 49483520 2858945 1387639..1388919 1 NC_002952.2 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1388919 2858945 SAR1338 Staphylococcus aureus subsp. aureus MRSA252 homoserine dehydrogenase YP_040744.1 1387639 D 282458 CDS YP_040745.1 49483521 2859531 1388925..1389986 1 NC_002952.2 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1389986 thrC 2859531 thrC Staphylococcus aureus subsp. aureus MRSA252 threonine synthase YP_040745.1 1388925 D 282458 CDS YP_040746.1 49483522 2859530 1389988..1390902 1 NC_002952.2 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1390902 thrB 2859530 thrB Staphylococcus aureus subsp. aureus MRSA252 homoserine kinase YP_040746.1 1389988 D 282458 CDS YP_040747.1 49483523 2858946 1390960..1391763 1 NC_002952.2 Similar to Vibrio cholerae hypothetical protein VC1364 TR:Q9KS95 (EMBL:AE004216) (273 aa) fasta scores: E(): 6.4e-22, 33.459% id in 266 aa, and to Lactococcus lactis hypothetical protein YkiF TR:Q9CGM1 (EMBL:AE006340) (271 aa) fasta scores: E(): 1.1e-20, 31.461% id in 267 aa; haloacid dehalogenase-like hydrolase 1391763 2858946 SAR1341 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_040747.1 1390960 D 282458 CDS YP_040748.1 49483524 2858947 complement(1392055..1392369) 1 NC_002952.2 hypothetical protein 1392369 2858947 SAR1342 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040748.1 1392055 R 282458 CDS YP_040749.1 49483525 2858948 complement(1392588..1394042) 1 NC_002952.2 Similar to Escherichia coli lysine-specific permease LysP SW:LYSP_ECOLI (P25737) (488 aa) fasta scores: E(): 2.3e-76, 45.720% id in 479 aa, and to Lactococcus lactis lysine specific permease LysP TR:Q9CDM6 (EMBL:AE006448) (506 aa) fasta scores: E(): 1.4e-74, 44.650% id in 486 aa; amino acid permease 1394042 2858948 SAR1343 Staphylococcus aureus subsp. aureus MRSA252 amino acid permease YP_040749.1 1392588 R 282458 CDS YP_040750.1 49483526 2858949 1394246..1395763 1 NC_002952.2 Previously sequenced as Staphylococcus aureus subsp. anaerobius catalase TR:Q9L4S1 (EMBL:AJ000472) (505 aa) fasta scores: E(): 8.4e-210, 99.208% id in 505 aa. Similar to Staphylococcus warneri catalase TR:Q9KW19 (EMBL:AB045340) (505 aa) fasta scores: E(): 4.1e-195, 90.476% id in 504 aa; catalase 1395763 2858949 SAR1344 Staphylococcus aureus subsp. aureus MRSA252 catalase YP_040750.1 1394246 D 282458 CDS YP_040751.1 49483527 2860163 1395854..1396003 1 NC_002952.2 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1396003 rpmG 2860163 rpmG Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L33 YP_040751.1 1395854 D 282458 CDS YP_040752.1 49483528 2858950 1396457..1396726 1 NC_002952.2 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 1396726 rpsN 2858950 rpsN Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S14 YP_040752.1 1396457 D 282458 CDS YP_040753.1 49483529 2858951 1396883..1397860 1 NC_002952.2 Similar to Ascaris suum GMP reductase SW:GUAC_ASCSU (P27442) (356 aa) fasta scores: E(): 2.8e-26, 33.846% id in 325 aa, and to Bacillus subtilis hypothetical protein YumD TR:O05269 (EMBL:Z93939) (326 aa) fasta scores: E(): 2.6e-94, 77.019% id in 322 aa; guanosine 5'-monophosphate oxidoreductase 1397860 2858951 SAR1347 Staphylococcus aureus subsp. aureus MRSA252 guanosine 5'-monophosphate oxidoreductase YP_040753.1 1396883 D 282458 CDS YP_040754.1 49483530 2858952 1398035..1398898 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YlbC TR:O34586 (EMBL:Z99111) (346 aa) fasta scores: E(): 5.7e-11, 29.474% id in 285 aa, and to Bacillus halodurans hypothetical protein BH2604 TR:Q9K9P1 (EMBL:AP001516) (363 aa) fasta scores: E(): 1.3e-08, 27.632% id in 304 aa; hypothetical protein 1398898 2858952 SAR1348 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040754.1 1398035 D 282458 CDS YP_040755.1 49483531 2859592 complement(1399278..1399901) 1 NC_002952.2 Represses a number of genes involved in the response to DNA damage; LexA repressor 1399901 dinR 2859592 dinR Staphylococcus aureus subsp. aureus MRSA252 LexA repressor YP_040755.1 1399278 R 282458 CDS YP_040756.1 49483532 2858953 1400041..1400277 1 NC_002952.2 hypothetical protein 1400277 2858953 SAR1350 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040756.1 1400041 D 282458 CDS YP_040757.1 49483533 2858954 1400413..1400652 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YlaC TR:Q9CGJ9 (EMBL:AE006342) (80 aa) fasta scores: E(): 2.4e-09, 48.750% id in 80 aa, and to Streptococcus pyogenes hypothetical protein SPY1687 TR:Q99YI5 (EMBL:AE006599) (85 aa) fasta scores: E(): 2.6e-09, 54.412% id in 68 aa; hypothetical protein 1400652 2858954 SAR1351 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040757.1 1400413 D 282458 CDS YP_040758.1 49483534 2858955 1400773..1402761 1 NC_002952.2 Similar to Craterostigma plantagineum transketolase 10 TKT10 SW:TKTA_CRAPL (Q42675) (679 aa) fasta scores: E(): 6.6e-118, 48.402% id in 657 aa, and to Bacillus subtilis transketolase Tkt SW:TKT_BACSU (P45694) (667 aa) fasta scores: E(): 3.2e-159, 61.061% id in 660 aa; transketolase 1402761 2858955 SAR1352 Staphylococcus aureus subsp. aureus MRSA252 transketolase YP_040758.1 1400773 D 282458 CDS YP_040759.1 49483535 2858956 1403039..1403281 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YneF SW:YNEF_BACSU (P45708) (72 aa) fasta scores: E(): 6.2e-15, 70.588% id in 68 aa, and to Bacillus halodurans hypothetical protein BH2350 SW:YN50_BACHD (Q9KAD9) (72 aa) fasta scores: E(): 3.3e-13, 58.571% id in 70 aa; hypothetical protein 1403281 2858956 SAR1353 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040759.1 1403039 D 282458 CDS YP_040760.1 49483536 2858957 1403460..1403927 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein required for cytochrome c synthesis, CcdC SW:CCDC_BACSU (P45710) (160 aa) fasta scores: E(): 1e-30, 56.579% id in 152 aa, and to Bacillus halodurans hypothetical protein BH2333 TR:Q9KAF4 (EMBL:AP001515) (169 aa) fasta scores: E(): 4e-29, 53.642% id in 151 aa; hypothetical protein 1403927 2858957 SAR1355 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040760.1 1403460 D 282458 CDS YP_040761.1 49483537 2858958 1404051..1405172 1 NC_002952.2 Similar to Escherichia coli ATP-dependent dsDNA exonuclease SbcD SW:SBCD_ECOLI (P13457) (400 aa) fasta scores: E(): 0.00012, 23.929% id in 397 aa, and to Vibrio cholerae exonuclease VCA520 TR:Q9KM68 (EMBL:AE004382) (379 aa) fasta scores: E(): 8e-39, 33.780% id in 373 aa; exonuclease 1405172 2858958 SAR1356 Staphylococcus aureus subsp. aureus MRSA252 exonuclease YP_040761.1 1404051 D 282458 CDS YP_040762.1 49483538 2858959 1405176..1408205 1 NC_002952.2 Similar to Escherichia coli ATP-dependent dsDNA exonuclease SbcC SW:SBCC_ECOLI (P13458) (1048 aa) fasta scores: E(): 1.1e-10, 22.120% id in 1085 aa, and to Vibrio cholerae exonuclease VCA0521 TR:Q9KM67 (EMBL:AE004382) (1013 aa) fasta scores: E(): 1e-38, 26.839% id in 1047 aa. Contains coiled-coiled domains; exonuclease 1408205 2858959 SAR1357 Staphylococcus aureus subsp. aureus MRSA252 exonuclease YP_040762.1 1405176 D 282458 CDS YP_040763.1 49483539 2858960 1408278..1409033 1 NC_002952.2 C-terminal region is similar to Lactobacillus johnsonii insertion element IS1223 hypothetical protein SW:YI3A_LACJO (Q48585) (177 aa) fasta scores: E(): 2.7e-08, 33.140% id in 172 aa, and Lactococcus lactis hypothetical protein YgcE TR:O32786 (EMBL:X92946) (185 aa) fasta scores: E(): 7.2e-06, 26.404% id in 178 aa; insertion element protein 1409033 2858960 SAR1358 Staphylococcus aureus subsp. aureus MRSA252 insertion element protein YP_040763.1 1408278 D 282458 CDS YP_040764.1 49483540 2858961 1409057..1409845 1 NC_002952.2 Similar to the C-terminal region of Enterococcus faecium transposase TR:Q47815 (EMBL:L40841) (310 aa) fasta scores: E(): 1.9e-39, 46.183% id in 262 aa, and to the full length Klebsiella pneumoniae hypothetical protein TR:Q9AG21 (EMBL:AF345899) (281 aa) fasta scores: E(): 3e-27, 37.308% id in 260 aa; transposase 1409845 2858961 SAR1359 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040764.1 1409057 D 282458 CDS YP_040765.1 49483541 2861312 complement(1409939..1410301) 1 NC_002952.2 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 1410301 mscL 2861312 mscL Staphylococcus aureus subsp. aureus MRSA252 large-conductance mechanosensitive channel YP_040765.1 1409939 R 282458 CDS YP_040766.1 49483542 2861469 1410505..1412151 1 NC_002952.2 Similar to Bacillus subtilis glycine betaine transporter OpuD SW:OPUD_BACSU (P54417) (512 aa) fasta scores: E(): 2.3e-109, 56.048% id in 496 aa, and to Listeria monocytogenes glycine betaine transporter BetL TR:Q9X4A5 (EMBL:AF102174) (507 aa) fasta scores: E(): 1.7e-106, 56.126% id in 506 aa; glycine betaine transporter 1 1412151 opuD1 2861469 opuD1 Staphylococcus aureus subsp. aureus MRSA252 glycine betaine transporter 1 YP_040766.1 1410505 D 282458 CDS YP_040767.1 49483543 2861357 1412719..1415424 1 NC_002952.2 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1415424 citB 2861357 citB Staphylococcus aureus subsp. aureus MRSA252 aconitate hydratase YP_040767.1 1412719 D 282458 CDS YP_040768.1 49483544 2858962 1415605..1416072 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2288 TR:Q9KAJ9 (EMBL:AP001515) (143 aa) fasta scores: E(): 1.3e-27, 51.128% id in 133 aa, and to Bacillus subtilis hypothetical protein YneP TR:Q45061 (EMBL:Z73234) (121 aa) fasta scores: E(): 4.2e-23, 47.500% id in 120 aa; hypothetical protein 1416072 2858962 SAR1363 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040768.1 1415605 D 282458 CDS YP_040769.1 49483545 2858963 complement(1416281..1416577) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2252 TR:Q9KAN5 (EMBL:AP001514) (95 aa) fasta scores: E(): 1.5e-07, 37.500% id in 96 aa, and to Bacillus subtilis hypothetical protein YneR TR:Q45063 (EMBL:Z73234) (95 aa) fasta scores: E(): 4.6e-07, 34.409% id in 93 aa; hypothetical protein 1416577 2858963 SAR1364 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040769.1 1416281 R 282458 CDS YP_040770.1 49483546 2858964 complement(1416955..1417563) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YkaC TR:Q9CGW4 (EMBL:AE006332) (213 aa) fasta scores: E(): 4.6e-25, 42.500% id in 200 aa, and to Streptococcus pyogenes hypothetical protein SPY0908 TR:Q9A070 (EMBL:AE006539) (213 aa) fasta scores: E(): 6.8e-22, 40.952% id in 210 aa; hypothetical protein 1417563 2858964 SAR1365 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040770.1 1416955 R 282458 CDS YP_040771.1 49483547 2859942 1417763..1419760 1 NC_002952.2 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1419760 grlB 2859942 grlB Staphylococcus aureus subsp. aureus MRSA252 DNA topoisomerase IV subunit B YP_040771.1 1417763 D 282458 CDS YP_040772.1 49483548 2859941 1419760..1422162 1 NC_002952.2 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 1422162 grlA 2859941 grlA Staphylococcus aureus subsp. aureus MRSA252 DNA topoisomerase IV subunit A YP_040772.1 1419760 D 282458 CDS YP_040773.1 49483549 2858965 1422412..1423872 1 NC_002952.2 Similar to Bacillus halodurans amino acid carrier protein BH1772 TR:Q9KC02 (EMBL:AP001513) (481 aa) fasta scores: E(): 1.1e-90, 53.347% id in 478 aa, and to Bacillus subtilis amino acid carrier protein AlsT SW:ALST_BACSU (Q45068) (465 aa) fasta scores: E(): 4e-90, 53.277% id in 473 aa; sodium:alanine symporter family protein 1423872 2858965 SAR1368 Staphylococcus aureus subsp. aureus MRSA252 sodium:alanine symporter family protein YP_040773.1 1422412 D 282458 CDS YP_040774.1 49483550 2861431 1424372..1425223 1 NC_002952.2 Similar to Bacillus subtilis transcription antiterminator LicT SW:LICT_BACSU (P39805) (277 aa) fasta scores: E(): 1.4e-22, 31.502% id in 273 aa, and to Staphylococcus carnosus antiterminator GlcT TR:O33618 (EMBL:Y14029) (287 aa) fasta scores: E(): 1.3e-59, 58.363% id in 281 aa; transcription antiterminator 1425223 2861431 SAR1369 Staphylococcus aureus subsp. aureus MRSA252 transcription antiterminator YP_040774.1 1424372 D 282458 CDS YP_040775.1 49483551 2861432 1425270..1425365 1 NC_002952.2 Doubtful CDS. No significant database matches; hypothetical protein 1425365 2861432 SAR1370 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040775.1 1425270 D 282458 CDS YP_040776.1 49483552 2861433 1425358..1426566 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YubA SW:YUBA_BACSU (O32086) (388 aa) fasta scores: E(): 1.6e-59, 45.119% id in 379 aa, and to Bacillus subtilis hypothetical protein YueF SW:YUEF_BACSU (O32095) (369 aa) fasta scores: E(): 1.4e-41, 33.520% id in 358 aa; hypothetical protein 1426566 2861433 SAR1371 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040776.1 1425358 D 282458 CDS YP_040777.1 49483553 2861306 1427047..1429569 1 NC_002952.2 Similar to Staphylococcus aureus membrane protein MprF TR:AAK58115 (EMBL:AF145699) (840 aa) fasta scores: E(): 0, 96.190% id in 840 aa. Similar to Staphylococcus xylosus membrane protein MprF TR:AAK58113 (EMBL:AF145698) (841 aa) fasta scores: E(): 5.4e-208, 62.530% id in 838 aa. Mutations in the CDS have reduced resistance to human defensins and evasion of neutrophil killing; hypothetical protein 1429569 mprF 2861306 mprF Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040777.1 1427047 D 282458 CDS YP_040778.1 49483554 2861313 complement(1429772..1430281) 1 NC_002952.2 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 1430281 msrA1 2861313 msrA1 Staphylococcus aureus subsp. aureus MRSA252 methionine sulfoxide reductase A YP_040778.1 1429772 R 282458 CDS YP_040779.1 49483555 2861434 1430418..1431401 1 NC_002952.2 Similar to Enterococcus faecalis hypothetical protein Psr TR:Q9K2N9 (EMBL:AJ276232) (390 aa) fasta scores: E(): 5.5e-42, 41.801% id in 311 aa, and to Enterococcus hirae hypothetical protein Psr TR:Q47828 (EMBL:U42211) (293 aa) fasta scores: E(): 2.8e-37, 39.274% id in 303 aa; hypothetical protein 1431401 2861434 SAR1374 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040779.1 1430418 D 282458 CDS YP_040780.1 49483556 2861435 complement(1431432..1433078) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 9.8e-199, 99.453% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 3.5e-99, 52.115% id in 520 aa; transposase 1433078 2861435 SAR1375 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040780.1 1431432 R 282458 CDS YP_040781.1 49483557 2861436 complement(1433402..1433590) 1 NC_002952.2 Similar to Pseudomonas putida 4-oxalocrotonate tautomerase XylH SW:XYLH_PSEPU (Q01468) (62 aa) fasta scores: E(): 6.6e-06, 40.741% id in 54 aa, and to Bacillus halodurans 4-oxalocrotonate tautomerase BH3814 TR:Q9K6B5 (EMBL:AP001520) (61 aa) fasta scores: E(): 9e-12, 65.574% id in 61 aa; 4-oxalocrotonate tautomerase 1433590 2861436 SAR1376 Staphylococcus aureus subsp. aureus MRSA252 4-oxalocrotonate tautomerase YP_040781.1 1433402 R 282458 CDS YP_040782.1 49483558 2861437 1433735..1434997 1 NC_002952.2 Similar to Bacillus anthracis plasmid pXO2 hypothetical protein pXO2-69 TR:Q9RMW5 (EMBL:AF188935) (421 aa) fasta scores: E(): 1.1e-87, 50.594% id in 421 aa, and to bacteriophage SPBc2 ImpB/MucB/SamB family protein YolE TR:O64031 (EMBL:AF020713) (416 aa) fasta scores: E(): 2.1e-68, 44.787% id in 422 aa; ImpB/MucB/SamB family protein 1434997 2861437 SAR1377 Staphylococcus aureus subsp. aureus MRSA252 ImpB/MucB/SamB family protein YP_040782.1 1433735 D 282458 CDS YP_040783.1 49483559 2861438 complement(1435133..1436224) 1 NC_002952.2 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 1436224 2861438 SAR1378 Staphylococcus aureus subsp. aureus MRSA252 prephenate dehydrogenase YP_040783.1 1435133 R 282458 CDS YP_040784.1 49483560 2861439 1436389..1437420 1 NC_002952.2 Similar to Lactococcus lactis glutamyl-aminopeptidase PepA SW:PEPA_LACLC (Q48677) (355 aa) fasta scores: E(): 6.1e-10, 24.294% id in 354 aa, and to Bacillus subtilis hypothetical protein YhfE TR:O07603 (EMBL:Y14083) (346 aa) fasta scores: E(): 3.2e-79, 60.947% id in 338 aa; peptidase 1437420 2861439 SAR1379 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_040784.1 1436389 D 282458 CDS YP_040785.1 49483561 2860401 1437913..1439319 1 NC_002952.2 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1439319 trpE 2860401 trpE Staphylococcus aureus subsp. aureus MRSA252 anthranilate synthase component I YP_040785.1 1437913 D 282458 CDS YP_040786.1 49483562 2860403 1439316..1439882 1 NC_002952.2 Similar to Lactococcus lactis anthranilate synthase component II TrpG SW:TRPG_LACLA (Q02003) (198 aa) fasta scores: E(): 3.7e-23, 42.188% id in 192 aa, and to Streptococcus pyogenes anthranilate synthase component II SPY1991 TR:Q99XW5 (EMBL:AE006622) (188 aa) fasta scores: E(): 4.1e-24, 38.542% id in 192 aa; anthranilate synthase component II 1439882 trpG 2860403 trpG Staphylococcus aureus subsp. aureus MRSA252 anthranilate synthase component II YP_040786.1 1439316 D 282458 CDS YP_040787.1 49483563 2860399 1440886..1441668 1 NC_002952.2 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 1441668 trpC 2860399 trpC Staphylococcus aureus subsp. aureus MRSA252 indole-3-glycerol-phosphate synthase YP_040787.1 1440886 D 282458 CDS YP_040788.1 49483564 2860402 1441668..1442300 1 NC_002952.2 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 1442300 trpF 2860402 trpF Staphylococcus aureus subsp. aureus MRSA252 N-(5'-phosphoribosyl)anthranilate isomerase YP_040788.1 1441668 D 282458 CDS YP_040789.1 49483565 2860398 1442293..1443507 1 NC_002952.2 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1443507 trpB 2860398 trpB Staphylococcus aureus subsp. aureus MRSA252 tryptophan synthase subunit beta YP_040789.1 1442293 D 282458 CDS YP_040790.1 49483566 2860397 1443500..1444228 1 NC_002952.2 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1444228 trpA 2860397 trpA Staphylococcus aureus subsp. aureus MRSA252 tryptophan synthase subunit alpha YP_040790.1 1443500 D 282458 CDS YP_040791.1 49483567 2860660 1444550..1445812 1 NC_002952.2 Previously sequenced as Staphylococcus aureus factor essential for expression of methicillin resistance FemA SW:FEMA_STAAU (P14304) (433 aa) fasta scores: E(): 2e-155, 99.524% id in 420 aa. Similar to Staphylococcus epidermidis FemA TR:P95734 (EMBL:U23713) (422 aa) fasta scores: E(): 6.5e-130, 81.490% id in 416 aa; factor essential for expression of methicillin resistance 1445812 femA 2860660 femA Staphylococcus aureus subsp. aureus MRSA252 factor essential for expression of methicillin resistance YP_040791.1 1444550 D 282458 CDS YP_040792.1 49483568 2860661 1445831..1447090 1 NC_002952.2 Similar to Staphylococcus aureus possible protein FemB SW:FEMB_STAAU (P14305) (419 aa) fasta scores: E(): 1.5e-161, 100.000% id in 419 aa, and to Staphylococcus epidermidis FemB TR:P95735 (EMBL:U23714) (417 aa) fasta scores: E(): 2.9e-141, 86.158% id in 419 aa; methicillin resistance expression factor 1447090 femB 2860661 femB Staphylococcus aureus subsp. aureus MRSA252 methicillin resistance expression factor YP_040792.1 1445831 D 282458 CDS YP_040793.1 49483569 2861441 complement(1448569..1449027) 1 NC_002952.2 hypothetical protein 1449027 2861441 SAR1391 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040793.1 1448569 R 282458 CDS YP_040794.1 49483570 2861442 complement(1449150..1449851) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus oligopeptide transporter ATPase Opp-2F TR:Q9ZGN3 (EMBL:AF076684) (233 aa) fasta scores: E(): 1.3e-77, 99.142% id in 233 aa. Similar to Chlamydia trachomatis oligopeptide transport ATPase CT202 TR:O84205 (EMBL:AE001293) (247 aa) fasta scores: E(): 3.9e-16, 30.833% id in 240 aa; oligopeptide transporter ATPase 1449851 2861442 SAR1392 Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transporter ATPase YP_040794.1 1449150 R 282458 CDS YP_040795.1 49483571 2861443 complement(1449844..1450617) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus oligopeptide transporter ATPase Opp-2D TR:Q9ZGN4 (EMBL:AF076684) (258 aa) fasta scores: E(): 4.5e-88, 96.887% id in 257 aa. Similar to Chlamydia pneumoniae oligopeptide transport ATPase CPN0201 TR:Q9Z8Y3 (EMBL:AE001606) (284 aa) fasta scores: E(): 1e-23, 35.547% id in 256 aa; oligopeptide transporter ATPase 1450617 2861443 SAR1393 Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transporter ATPase YP_040795.1 1449844 R 282458 CDS YP_040796.1 49483572 2861444 complement(1450604..1451434) 1 NC_002952.2 Similar to Escherichia coli dipeptide ABC transporter permease DppC SW:DPPC_ECOLI (P37315) (300 aa) fasta scores: E(): 2e-28, 33.333% id in 273 aa. Previously sequenced as Staphylococcus aureus oligopeptide transporter membrane permease Opp-2C TR:Q9ZGN5 (EMBL:AF076684) (276 aa) fasta scores: E(): 4.9e-102, 98.188% id in 276 aa; oligopeptide ABC transporter permease 1451434 2861444 SAR1394 Staphylococcus aureus subsp. aureus MRSA252 oligopeptide ABC transporter permease YP_040796.1 1450604 R 282458 CDS YP_040797.1 49483573 2861445 complement(1451427..1452413) 1 NC_002952.2 Similar to Escherichia coli nickel ABC transporter permease NikB SW:NIKB_ECOLI (P33591) (314 aa) fasta scores: E(): 2.4e-30, 32.797% id in 311 aa. Previously sequenced as Staphylococcus aureus oligopeptide transporter membrane permease Opp-2B TR:Q9ZGN6 (EMBL:AF076684) (328 aa) fasta scores: E(): 1.2e-115, 97.256% id in 328 aa; oligopeptide ABC transporter permease 1452413 2861445 SAR1395 Staphylococcus aureus subsp. aureus MRSA252 oligopeptide ABC transporter permease YP_040797.1 1451427 R 282458 CDS YP_040798.1 49483574 2861152 complement(1452717..1453061) 1 NC_002952.2 Poor database matches. Weakly similar to the C-terminal region of Vibrio cholerae hypothetical protein VC2101 TR:Q9KQ99 (EMBL:AE004284) (146 aa) fasta scores: E(): 4.4, 26.214% id in 103 aa; hypothetical protein 1453061 2861152 SAR1396 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040798.1 1452717 R 282458 CDS YP_040799.1 49483575 2860183 1453266..1455080 1 NC_002952.2 Similar to Lactococcus lactis plasmid pLP763 oligoendopeptidase F PepF SW:PEF1_LACLC (P54124) (601 aa) fasta scores: E(): 5.7e-39, 23.786% id in 597 aa, and to Streptococcus pyogenes oligopeptidase SPY0606 TR:Q9A0U8 (EMBL:AE006515) (599 aa) fasta scores: E(): 3.7e-91, 42.070% id in 599 aa; peptidase 1455080 2860183 SAR1397 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_040799.1 1453266 D 282458 CDS YP_040800.1 49483576 2860184 complement(1455220..1455861) 1 NC_002952.2 Similar to Escherichia coli phosphate transporter PhoU SW:PHOU_ECOLI (P07656) (241 aa) fasta scores: E(): 8.9e-14, 28.241% id in 216 aa, and to Rhizobium meliloti phosphate transporter SMC02141 SW:PHOU_RHIME (Q52989) (237 aa) fasta scores: E(): 5e-15, 30.233% id in 215 aa; phosphate transporter 1455861 2860184 SAR1398 Staphylococcus aureus subsp. aureus MRSA252 phosphate transporter YP_040800.1 1455220 R 282458 CDS YP_040801.1 49483577 2860185 complement(1455868..1456719) 1 NC_002952.2 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1456719 2860185 SAR1399 Staphylococcus aureus subsp. aureus MRSA252 phosphate transporter ATP-binding protein YP_040801.1 1455868 R 282458 CDS YP_040802.1 49483578 2860186 complement(1456766..1457683) 1 NC_002952.2 Similar to Escherichia coli phosphate ABC transporter permease PstA SW:PSTA_ECOLI (P07654) (296 aa) fasta scores: E(): 7.7e-23, 31.707% id in 287 aa, and to Bacillus halodurans phosphate ABC transporter BH2992 TR:Q9K8L4 (EMBL:AP001517) (294 aa) fasta scores: E(): 1e-55, 52.703% id in 296 aa; ABC transporter permease 1457683 2860186 SAR1400 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_040802.1 1456766 R 282458 CDS YP_040803.1 49483579 2860187 complement(1457685..1458611) 1 NC_002952.2 Similar to Bacillus halodurans phosphate ABC transporter BH2993 TR:Q9K8L3 (EMBL:AP001517) (318 aa) fasta scores: E(): 2.1e-64, 61.564% id in 307 aa, and to Archaeoglobus fulgidus phosphate ABC transporter, permease AF1357 TR:O28914 (EMBL:AE001010) (297 aa) fasta scores: E(): 5.2e-47, 47.959% id in 294 aa; ABC transporter permease 1458611 2860187 SAR1401 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_040803.1 1457685 R 282458 CDS YP_040804.1 49483580 2860188 complement(1458802..1459785) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus thioredoxine reductase TR:Q9RL86 (EMBL:Y18637) (327 aa) fasta scores: E(): 4.6e-107, 99.694% id in 327 aa. Similar to Synechococcus sp phosphate assimilation protein SphX SW:SPHX_SYNP7 (P39665) (337 aa) fasta scores: E(): 2.6e-28, 37.363% id in 273 aa; phosphate-binding lipoprotein 1459785 2860188 SAR1402 Staphylococcus aureus subsp. aureus MRSA252 phosphate-binding lipoprotein YP_040804.1 1458802 R 282458 CDS YP_040805.1 49483581 2860189 complement(1460096..1460998) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YitL TR:O06747 (EMBL:Z99109) (298 aa) fasta scores: E(): 5.8e-30, 37.354% id in 257 aa, and to Bacillus halodurans hypothetical protein BH1329 TR:Q9KD88 (EMBL:AP001511) (290 aa) fasta scores: E(): 2.6e-25, 33.579% id in 271 aa; hypothetical protein 1460998 2860189 SAR1403 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040805.1 1460096 R 282458 CDS YP_040806.1 49483582 2860190 1461145..1462746 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkpA TR:O31716 (EMBL:Z99111) (540 aa) fasta scores: E(): 5.8e-131, 73.921% id in 533 aa, and to Streptococcus pyogenes ABC transporter ATP-binding protein SPY2210 TR:Q99XH2 (EMBL:AE006638) (539 aa) fasta scores: E(): 1e-115, 66.034% id in 527 aa; ABC transporter ATP-binding protein 1462746 2860190 SAR1404 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_040806.1 1461145 D 282458 CDS YP_040807.1 49483583 2859813 1463603..1464808 1 NC_002952.2 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 1464808 lysC 2859813 lysC Staphylococcus aureus subsp. aureus MRSA252 aspartate kinase YP_040807.1 1463603 D 282458 CDS YP_040808.1 49483584 2859869 1464872..1465861 1 NC_002952.2 Previously sequenced as Staphylococcus aureus aspartate semialdehyde dehydrogenase Asd TR:Q9EZ13 (EMBL:AF306669) (329 aa) fasta scores: E(): 1.3e-120, 98.784% id in 329 aa. Similar to Deinococcus radiodurans aspartate-semialdehyde dehydrogenase DR2008 TR:Q9RSW3 (EMBL:AE002038) (338 aa) fasta scores: E(): 1.5e-44, 43.844% id in 333 aa; aspartate semialdehyde dehydrogenase 1465861 asd 2859869 asd Staphylococcus aureus subsp. aureus MRSA252 aspartate semialdehyde dehydrogenase YP_040808.1 1464872 D 282458 CDS YP_040809.1 49483585 2859262 1465863..1466750 1 NC_002952.2 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 1466750 dapA 2859262 dapA Staphylococcus aureus subsp. aureus MRSA252 dihydrodipicolinate synthase YP_040809.1 1465863 D 282458 CDS YP_040810.1 49483586 2859263 1466747..1467469 1 NC_002952.2 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1467469 dapB 2859263 dapB Staphylococcus aureus subsp. aureus MRSA252 dihydrodipicolinate reductase YP_040810.1 1466747 D 282458 CDS YP_040811.1 49483587 2859264 1467496..1468215 1 NC_002952.2 Similar to Escherichia coli 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase DapD or b0166 SW:DAPD_ECOLI (P03948) (274 aa) fasta scores: E(): 6.4e-11, 40.288% id in 139 aa. Previously sequenced as Staphylococcus aureus tetrahydrodipicolinate acetyltransferase DapD TR:Q9EZ10 (EMBL:AF306669) (239 aa) fasta scores: E(): 1.2e-81, 99.582% id in 239 aa; tetrahydrodipicolinate acetyltransferase 1468215 dapD 2859264 dapD Staphylococcus aureus subsp. aureus MRSA252 tetrahydrodipicolinate acetyltransferase YP_040811.1 1467496 D 282458 CDS YP_040812.1 49483588 2860191 1468358..1469509 1 NC_002952.2 Similar to Pyrococcus horikoshii hypothetical amidohydrolase PH1043 TR:O58754 (EMBL:AP000004) (387 aa) fasta scores: E(): 9.4e-39, 35.753% id in 372 aa. Previously sequenced as Staphylococcus aureus hippurate hydrolase HipO TR:Q9EZ09 (EMBL:AF306669) (383 aa) fasta scores: E(): 1.4e-158, 99.217% id in 383 aa; peptidase 1469509 2860191 SAR1410 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_040812.1 1468358 D 282458 CDS YP_040813.1 49483589 2859261 1469514..1470599 1 NC_002952.2 Similar to Staphylococcus aureus alanine racemase Alr SW:ALR_STAAU (Q9ZAH5) (382 aa) fasta scores: E(): 2.4e-18, 28.660% id in 321 aa. Previously sequenced as Staphylococcus aureus alanine racemase Dal TR:Q9EZ08 (EMBL:AF306669) (336 aa) fasta scores: E(): 8.7e-137, 99.405% id in 336 aa; alanine racemase 1470599 dal 2859261 dal Staphylococcus aureus subsp. aureus MRSA252 alanine racemase YP_040813.1 1469514 D 282458 CDS YP_040814.1 49483590 2859812 1470589..1471854 1 NC_002952.2 Similar to Bacillus subtilis diaminopimelate decarboxylase LysA SW:DCDA_BACSU (P23630) (441 aa) fasta scores: E(): 3e-75, 49.296% id in 426 aa. Previously sequenced as Staphylococcus aureus diaminopimelate decarboxylase LysA TR:Q9KWX7 (EMBL:Y18632) (283 aa) fasta scores: E(): 2.9e-100, 98.233% id in 283 aa; diaminopimelate decarboxylase 1471854 lysA 2859812 lysA Staphylococcus aureus subsp. aureus MRSA252 diaminopimelate decarboxylase YP_040814.1 1470589 D 282458 CDS YP_040815.1 49483591 2860192 complement(1472090..1472491) 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Escherichia coli O157:H7 EDL933 endonuclease YihG TR:AAG59051 (EMBL:AE005616) (310 aa) fasta scores: E(): 1.1, 25.954% id in 131 aa; hypothetical protein 1472491 2860192 SAR1413 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040815.1 1472090 R 282458 CDS YP_040816.1 49483592 2859247 complement(1472688..1472888) 1 NC_002952.2 Similar to Bacillus subtilis cold shock protein CspD SW:CSPD_BACSU (P51777) (66 aa) fasta scores: E(): 4.6e-20, 78.788% id in 66 aa. Previously sequenced as Staphylococcus aureus major cold shock protein CspA TR:Q9L534 (EMBL:AF259960) (66 aa) fasta scores: E(): 5.9e-26, 100.000% id in 66 aa. Similar to SAR0848, 80.303% identity (80.303% ungapped) in 66 aa overlap, and to SAR2790, 73.016% identity (73.016% ungapped) in 63 aa overlap; cold shock protein 1472888 cspA 2859247 cspA Staphylococcus aureus subsp. aureus MRSA252 cold shock protein YP_040816.1 1472688 R 282458 CDS YP_040817.1 49483593 2860193 complement(1473059..1473367) 1 NC_002952.2 Poor database matches. Similar to Streptococcus pyogenes DNA binding protein SPY0100 TR:Q9A1U0 (EMBL:AE006481) (121 aa) fasta scores: E(): 2.7e-10, 31.915% id in 94 aa, and to Lactococcus lactis hypothetical protein YtbD TR:Q9CEJ2 (EMBL:AE006415) (122 aa) fasta scores: E(): 1.2e-05, 27.000% id in 100 aa; hypothetical protein 1473367 2860193 SAR1415 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040817.1 1473059 R 282458 CDS YP_040818.1 49483594 2860194 1473529..1473798 1 NC_002952.2 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1473798 2860194 SAR1416 Staphylococcus aureus subsp. aureus MRSA252 acylphosphatase YP_040818.1 1473529 D 282458 CDS YP_040819.1 49483595 2860195 1473823..1474446 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein XpaC SW:XPAC_BACSU (P37467) (204 aa) fasta scores: E(): 5.1e-11, 30.688% id in 189 aa; hypothetical protein 1474446 2860195 SAR1417 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040819.1 1473823 D 282458 CDS YP_040820.1 49483596 2860196 1474478..1475614 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YaaN SW:YAAN_BACSU (P37535) (386 aa) fasta scores: E(): 1.5e-51, 52.802% id in 339 aa, and to Lactococcus lactis hypothetical protein YnhC TR:Q9CFX8 (EMBL:AE006366) (392 aa) fasta scores: E(): 4.8e-47, 43.717% id in 382 aa; hypothetical protein 1475614 2860196 SAR1418 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040820.1 1474478 D 282458 CDS YP_040821.1 49483597 2860197 complement(1475682..1477025) 1 NC_002952.2 Similar to Lactobacillus delbrueckii branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_LACDL (P54104) (446 aa) fasta scores: E(): 4.5e-44, 35.440% id in 443 aa, and to Staphylococcus aureus branched-chain amino acid carrier protein TR:O34007 (EMBL:U87144) (441 aa) fasta scores: E(): 8.8e-116, 82.517% id in 429 aa; branched-chain amino acid transporter protein 1477025 2860197 SAR1419 Staphylococcus aureus subsp. aureus MRSA252 branched-chain amino acid transporter protein YP_040821.1 1475682 R 282458 CDS YP_040822.1 49483598 2860198 complement(1477250..1479136) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YojO TR:O31849 (EMBL:Z99114) (661 aa) fasta scores: E(): 1.4e-49, 37.364% id in 645 aa. C-terminus is similar to the C-terminal region of Rhizobium loti hypothetical protein MLL3561 TR:BAB50427 (EMBL:AP003002) (632 aa) fasta scores: E(): 0.065, 21.028% id in 428 aa; hypothetical protein 1479136 2860198 SAR1420 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040822.1 1477250 R 282458 CDS YP_040823.1 49483599 2860199 complement(1479150..1479941) 1 NC_002952.2 Similar to Pseudomonas stutzeri denitrification regulatory protein NirQ SW:NIRQ_PSEST (Q02441) (275 aa) fasta scores: E(): 4.2e-14, 30.417% id in 240 aa, and to Bacillus subtilis hypothetical protein YojN TR:O31850 (EMBL:Z99114) (304 aa) fasta scores: E(): 4.7e-51, 62.403% id in 258 aa; hypothetical protein 1479941 2860199 SAR1421 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040823.1 1479150 R 282458 CDS YP_040824.1 49483600 2860200 complement(1480122..1480325) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2203 TR:Q9KAT3 (EMBL:AP001514) (67 aa) fasta scores: E(): 2.3e-12, 57.812% id in 64 aa, and to Bacillus subtilis hypothetical protein YozC TR:O31848 (EMBL:Z99114) (67 aa) fasta scores: E(): 4.6e-12, 52.239% id in 67 aa; hypothetical protein 1480325 2860200 SAR1422 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040824.1 1480122 R 282458 CDS YP_040825.1 49483601 2860201 complement(1480354..1481163) 1 NC_002952.2 Similar to Rhizobium loti hypothetical protein MLL3759 TR:BAB50580 (EMBL:AP003002) (317 aa) fasta scores: E(): 7.7e-13, 26.087% id in 276 aa, and to Bacillus halodurans hypothetical protein BH2175 TR:Q9KAW1 (EMBL:AP001514) (327 aa) fasta scores: E(): 2.9e-12, 25.362% id in 276 aa; hypothetical protein 1481163 2860201 SAR1423 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040825.1 1480354 R 282458 CDS YP_040826.1 49483602 2859175 complement(1481753..1483024) 1 NC_002952.2 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 1483024 odhB 2859175 odhB Staphylococcus aureus subsp. aureus MRSA252 dihydrolipoamide succinyltransferase YP_040826.1 1481753 R 282458 CDS YP_040827.1 49483603 2859174 complement(1483038..1485836) 1 NC_002952.2 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 1485836 sucA 2859174 sucA Staphylococcus aureus subsp. aureus MRSA252 2-oxoglutarate dehydrogenase E1 component YP_040827.1 1483038 R 282458 CDS YP_040828.1 49483604 2859859 complement(1486310..1487665) 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Previously sequenced as Staphylococcus aureus protein histidine kinase ArlS TR:Q9KJN3 (EMBL:AF165314) (451 aa) fasta scores: E(): 1.6e-154, 99.778% id in 451 aa. Similar to Listeria monocytogenes histidine kinase homologue LisK TR:Q9RPY9 (EMBL:AF139908) (483 aa) fasta scores: E(): 9.4e-43, 35.118% id in 467 aa; sensor kinase 1487665 arlS 2859859 arlS Staphylococcus aureus subsp. aureus MRSA252 sensor kinase YP_040828.1 1486310 R 282458 CDS YP_040829.1 49483605 2859858 complement(1487662..1488321) 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Previously sequenced as Staphylococcus aureus response regulator ArlR TR:Q9KJN4 (EMBL:AF165314) (219 aa) fasta scores: E(): 8e-82, 100.000% id in 219 aa. Similar to Listeria monocytogenes LisR TR:Q9RPZ0 (EMBL:AF139908) (226 aa) fasta scores: E(): 2.9e-39, 53.744% id in 227 aa; response regulator protein 1488321 arlR 2859858 arlR Staphylococcus aureus subsp. aureus MRSA252 response regulator protein YP_040829.1 1487662 R 282458 CDS YP_040830.1 49483606 2860202 complement(1488791..1488964) 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 1488964 2860202 SAR1428 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040830.1 1488791 R 282458 CDS YP_040831.1 49483607 2860203 complement(1489107..1489721) 1 NC_002952.2 Similar to Bacillus megaterium hypothetical protein TR:Q06074 (EMBL:Z21972) (216 aa) fasta scores: E(): 3.9e-18, 38.220% id in 191 aa, and to Streptococcus pyogenes phosphatase TR:Q9AGC2 (EMBL:AF336821) (200 aa) fasta scores: E(): 2.3e-16, 36.313% id in 179 aa; hypothetical protein 1489721 2860203 SAR1429 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040831.1 1489107 R 282458 CDS YP_040832.1 49483608 2861324 complement(1489738..1490808) 1 NC_002952.2 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1490808 murG 2861324 murG Staphylococcus aureus subsp. aureus MRSA252 UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_040832.1 1489738 R 282458 CDS YP_040833.1 49483609 2860502 complement(1490820..1491329) 1 NC_002952.2 Similar to Campylobacter jejuni acetyltransferase CJ1715 TR:Q9PLW3 (EMBL:AL139079) (176 aa) fasta scores: E(): 1.3e-11, 33.939% id in 165 aa, and to Lactococcus lactis hypothetical protein YwfD TR:Q9CDP2 (EMBL:AE006446) (169 aa) fasta scores: E(): 1.4e-09, 32.237% id in 152 aa; acetyltransferase 1491329 2860502 SAR1431 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_040833.1 1490820 R 282458 CDS YP_040834.1 49483610 2860503 complement(1491730..1493220) 1 NC_002952.2 Similar to Bartonella bacilliformis carboxy-terminal processing protease precursor CtpA SW:CTPA_BARBA (Q44879) (434 aa) fasta scores: E(): 4.2e-34, 32.767% id in 412 aa, and to Bacillus subtilis carboxy-terminal processing protease YzbD TR:O34666 (EMBL:AF006665) (466 aa) fasta scores: E(): 5.6e-57, 42.325% id in 456 aa. CDS contains an extended N-terminus in comparison to other orthologues; protease 1493220 2860503 SAR1432 Staphylococcus aureus subsp. aureus MRSA252 protease YP_040834.1 1491730 R 282458 CDS YP_040835.1 49483611 2860504 1493459..1494406 1 NC_002952.2 Identical to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 2.6e-127, 100.000% id in 315 aa, and similar to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 2.9e-71, 58.413% id in 315 aa; transposase 1494406 2860504 SAR1433 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_040835.1 1493459 D 282458 CDS YP_040836.1 49483612 2860505 complement(1494479..1494700) 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY0467 TR:Q9A148 (EMBL:AE006506) (71 aa) fasta scores: E(): 2.5e-06, 38.462% id in 65 aa, and to Lactococcus lactis hypothetical protein YuiB TR:Q9CE43 (EMBL:AE006430) (69 aa) fasta scores: E(): 4e-06, 38.806% id in 67 aa; hypothetical protein 1494700 2860505 SAR1434 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040836.1 1494479 R 282458 CDS YP_040837.1 49483613 2860506 complement(1494700..1495200) 1 NC_002952.2 Similar to Escherichia coli PTS system, glucose-specific IIA component Crr SW:PTGA_ECOLI (P08837) (168 aa) fasta scores: E(): 8.6e-22, 41.975% id in 162 aa, and to Bacillus halodurans PTS system, glucose-specific enzyme IIA component BH1515 TR:Q9KCQ4 (EMBL:AP001512) (173 aa) fasta scores: E(): 1.1e-29, 50.888% id in 169 aa. N-terminus is similar to the C-terminal regions of SAR0190, 58.333% identity (58.333% ungapped) in 120 aa overlap, and SAR2618, 50.407% identity (50.407% ungapped) in 123 aa overlap; PTS system glucose-specific transporter subunit IIA 1495200 2860506 SAR1435 Staphylococcus aureus subsp. aureus MRSA252 PTS system glucose-specific transporter subunit IIA YP_040837.1 1494700 R 282458 CDS YP_040838.1 49483614 2860507 complement(1495212..1495640) 1 NC_002952.2 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1495640 2860507 SAR1436 Staphylococcus aureus subsp. aureus MRSA252 methionine sulfoxide reductase B YP_040838.1 1495212 R 282458 CDS YP_040839.1 49483615 2861314 complement(1495633..1496166) 1 NC_002952.2 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 1496166 msrA2 2861314 msrA2 Staphylococcus aureus subsp. aureus MRSA252 methionine sulfoxide reductase A YP_040839.1 1495633 R 282458 CDS YP_040840.1 49483616 2860508 complement(1496252..1497091) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YejH TR:Q9CI68 (EMBL:AE006285) (285 aa) fasta scores: E(): 2.1e-25, 35.401% id in 274 aa, and to Bacillus subtilis hypothetical protein DegV SW:DEGV_BACSU (P32436) (281 aa) fasta scores: E(): 2.8e-24, 34.066% id in 273 aa; hypothetical protein 1497091 2860508 SAR1438 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040840.1 1496252 R 282458 CDS YP_040841.1 49483617 2859591 complement(1497106..1497585) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus trimethoprim-sensitive dihydrofolate reductase type I DfrB SW:DYRB_STAAU (P10167) (158 aa) fasta scores: E(): 3.1e-62, 100.000% id in 158 aa. Similar to Staphylococcus epidermidis dihydrofolate reductase DfrC SW:DYR_STAEP (Q59908) (161 aa) fasta scores: E(): 4.1e-52, 81.761% id in 159 aa; dihydrofolate reductase 1497585 dfrB 2859591 dfrB Staphylococcus aureus subsp. aureus MRSA252 dihydrofolate reductase YP_040841.1 1497106 R 282458 CDS YP_040842.1 49483618 2859533 complement(1497785..1498741) 1 NC_002952.2 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 1498741 thyA 2859533 thyA Staphylococcus aureus subsp. aureus MRSA252 thymidylate synthase YP_040842.1 1497785 R 282458 CDS YP_040843.1 49483619 2860509 complement(1499165..1499602) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YphP SW:YPHP_BACSU (P54170) (144 aa) fasta scores: E(): 3.6e-27, 57.343% id in 143 aa, and to Bacillus halodurans hypothetical protein BH1716 TR:Q9KC58 (EMBL:AP001512) (144 aa) fasta scores: E(): 1.2e-24, 54.545% id in 143 aa; hypothetical protein 1499602 2860509 SAR1441 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040843.1 1499165 R 282458 CDS YP_040844.1 49483620 2860510 complement(1499618..1500742) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpgR SW:YPGR_BACSU (P54169) (377 aa) fasta scores: E(): 4.4e-58, 45.067% id in 375 aa, and to Bacillus halodurans hypothetical protein BH1718 TR:Q9KC56 (EMBL:AP001512) (380 aa) fasta scores: E(): 7.8e-58, 43.968% id in 373 aa; hypothetical protein 1500742 2860510 SAR1442 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040844.1 1499618 R 282458 CDS YP_040845.1 49483621 2860511 complement(1500780..1501031) 1 NC_002952.2 Similar to the N-terminal regions of Bacillus halodurans hypothetical protein BH1718 TR:Q9KC56 (EMBL:AP001512) (380 aa) fasta scores: E(): 6.3e-10, 42.169% id in 83 aa, and Bacillus subtilis hypothetical protein YpgR SW:YPGR_BACSU (P54169) (377 aa) fasta scores: E(): 3.5e-08, 38.554% id in 83 aa. Similar to N-terminal region SAR1442, 51.220% identity (51.220% ungapped) in 82 aa overlap. Possible gene remnant; hypothetical protein 1501031 2860511 SAR1443 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040845.1 1500780 R 282458 CDS YP_040846.1 49483622 2860512 complement(1501043..1501237) 1 NC_002952.2 Similar to the C-terminal region of Escherichia coli dnaK suppressor protein DksA SW:DKSA_ECOLI (P18274) (151 aa) fasta scores: E(): 1.3, 28.333% id in 60 aa, and to the full length Bacillus subtilis hypothetical protein YpeQ SW:YPEQ_BACSU (P54165) (60 aa) fasta scores: E(): 5.8e-07, 46.939% id in 49 aa; hypothetical protein 1501237 2860512 SAR1444 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040846.1 1501043 R 282458 CDS YP_040847.1 49483623 2860513 1501482..1502186 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpdP SW:YPDP_BACSU (P54163) (229 aa) fasta scores: E(): 3.3e-37, 46.575% id in 219 aa, and to Archaeoglobus fulgidus conserved hypothetical protein AF2110 TR:O28170 (EMBL:AE000958) (241 aa) fasta scores: E(): 3.4e-29, 38.559% id in 236 aa; hypothetical protein 1502186 2860513 SAR1445 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040847.1 1501482 D 282458 CDS YP_040848.1 49483624 2860514 1502427..1502828 1 NC_002952.2 Similar to Enterococcus faecalis possible cell wall metabolism enzyme EbsB SW:EBSB_ENTFA (P36921) (135 aa) fasta scores: E(): 9.2e-17, 41.481% id in 135 aa, and to Bacillus halodurans hypothetical protein BH1770 TR:Q9KC04 (EMBL:AP001513) (135 aa) fasta scores: E(): 4.1e-11, 32.540% id in 126 aa; hypothetical protein 1502828 2860514 SAR1446 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040848.1 1502427 D 282458 CDS YP_040849.1 49483625 2859609 complement(1502887..1535127) 1 NC_002952.2 Very large protein. No significant database matches to the full length CDS. CDS contains 3 regions containing repeats, residues 2515 to 3120, 3120 to 9780, 9780 to 10480. Internal repeat region similar to Abiotrophia defectiva extracellular matrix binding protein Emb TR:O85472 (EMBL:AF067776) (2055 aa) fasta scores: E(): 1.1e-34, 23.420% id in 2105 aa. C-terminal region contains a hydrophobic domain, residues 10552 to 10573, followed by charged carboxyl-terminal tail; hypothetical protein 1535127 ebh 2859609 ebh Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040849.1 1502887 R 282458 CDS YP_040850.1 49483626 2860515 complement(1535528..1536919) 1 NC_002952.2 Similar to Mycobacterium tuberculosis hypothetical protein MTCY98.02c TR:P71879 (EMBL:Z79702) (537 aa) fasta scores: E(): 2.6e-25, 28.883% id in 412 aa, and to Rhizobium loti transmembrane efflux protein MLL5686 TR:BAB52087 (EMBL:AP003007) (502 aa) fasta scores: E(): 1.6e-24, 27.470% id in 415 aa. Similar to SAR0109, 71.082% identity (71.082% ungapped) in 453 aa overlap, and to SAR2534, 57.204% identity (58.079% ungapped) in 465 aa overlap; transporter protein 1536919 2860515 SAR1448 Staphylococcus aureus subsp. aureus MRSA252 transporter protein YP_040850.1 1535528 R 282458 CDS YP_040851.1 49483627 2860516 complement(1537076..1538398) 1 NC_002952.2 Similar to an internal region of Mus musculus large neutral amino acids transporter small subunit 2 LAT2 SW:LAT2_MOUSE (Q9QXW9) (531 aa) fasta scores: E(): 4.8e-33, 31.027% id in 448 aa, and to the full length Bacillus subtilis hypothetical protein YkbA TR:O34739 (EMBL:Z99110) (438 aa) fasta scores: E(): 3.6e-63, 42.955% id in 440 aa; amino acid permease 1538398 2860516 SAR1449 Staphylococcus aureus subsp. aureus MRSA252 amino acid permease YP_040851.1 1537076 R 282458 CDS YP_040852.1 49483628 2859522 complement(1538429..1539469) 1 NC_002952.2 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 1539469 tdcB 2859522 tdcB Staphylococcus aureus subsp. aureus MRSA252 threonine dehydratase YP_040852.1 1538429 R 282458 CDS YP_040853.1 49483629 2860989 complement(1539564..1540682) 1 NC_002952.2 Similar to Bacillus subtilis alanine dehydrogenase Ald SW:DHA_BACSU (Q08352) (378 aa) fasta scores: E(): 1.2e-56, 46.612% id in 369 aa, and to Enterobacter aerogenes alanine dehydrogenase AlaDH TR:Q9WX54 (EMBL:AB013821) (377 aa) fasta scores: E(): 2.2e-57, 47.568% id in 370 aa; alanine dehydrogenase 1540682 ald2 2860989 ald2 Staphylococcus aureus subsp. aureus MRSA252 alanine dehydrogenase YP_040853.1 1539564 R 282458 CDS YP_040854.1 49483630 2860517 complement(1541157..1542035) 1 NC_002952.2 Similar to Bacillus subtilis 5'-3' exonuclease YpcP SW:YPCP_BACSU (P54161) (296 aa) fasta scores: E(): 1.9e-54, 54.023% id in 261 aa. N-terminus is similar to the N-terminal region of Bacillus subtilis DNA polymerase I PolA SW:DPO1_BACSU (O34996) (880 aa) fasta scores: E(): 8.7e-32, 39.370% id in 254 aa; 5'-3' exonuclease 1542035 2860517 SAR1452 Staphylococcus aureus subsp. aureus MRSA252 5'-3' exonuclease YP_040854.1 1541157 R 282458 CDS YP_040855.1 49483631 2860518 complement(1542055..1545495) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1700 TR:Q9KC74 (EMBL:AP001512) (1205 aa) fasta scores: E(): 2.1e-28, 24.816% id in 1225 aa, and to Bacillus subtilis hypothetical protein YpbR SW:YPBR_BACSU (P54159) (1193 aa) fasta scores: E(): 1.3e-24, 25.333% id in 1125 aa; hypothetical protein 1545495 2860518 SAR1453 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040855.1 1542055 R 282458 CDS YP_040856.1 49483632 2860520 complement(1547485..1547817) 1 NC_002952.2 hypothetical protein 1547817 2860520 SAR1455 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040856.1 1547485 R 282458 CDS YP_040857.1 49483633 2860521 complement(1547901..1549046) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpsC SW:YPSC_BACSU (P50840) (385 aa) fasta scores: E(): 3.7e-84, 56.806% id in 382 aa, and to Bacillus halodurans hypothetical protein BH1771 TR:Q9KC03 (EMBL:AP001513) (385 aa) fasta scores: E(): 1.3e-78, 56.000% id in 375 aa; hypothetical protein 1549046 2860521 SAR1456 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040857.1 1547901 R 282458 CDS YP_040858.1 49483634 2860522 complement(1549697..1550041) 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY1646 TR:Q99YL4 (EMBL:AE006595) (108 aa) fasta scores: E(): 1.4e-07, 41.818% id in 110 aa, and to Lactococcus lactis hypothetical protein YraB TR:Q9CF28 (EMBL:AE006396) (128 aa) fasta scores: E(): 2.9e-06, 43.089% id in 123 aa; hypothetical protein 1550041 2860522 SAR1457 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040858.1 1549697 R 282458 CDS YP_040859.1 49483635 2860523 complement(1550055..1550618) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpsA SW:YPSA_BACSU (P50838) (180 aa) fasta scores: E(): 5.2e-27, 42.938% id in 177 aa, and to Bacillus halodurans hypothetical protein BH1768 TR:Q9KC06 (EMBL:AP001513) (189 aa) fasta scores: E(): 2.8e-22, 36.022% id in 186 aa; hypothetical protein 1550618 2860523 SAR1458 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040859.1 1550055 R 282458 CDS YP_040860.1 49483636 2860524 complement(1550611..1550961) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1707 TR:Q9KC67 (EMBL:AP001512) (131 aa) fasta scores: E(): 0.024, 28.723% id in 94 aa, and to Bacillus subtilis hypothetical protein YppE SW:YPPE_BACSU (P50833) (123 aa) fasta scores: E(): 0.097, 22.609% id in 115 aa; hypothetical protein 1550961 2860524 SAR1459 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040860.1 1550611 R 282458 CDS YP_040861.1 49483637 2860525 complement(1551024..1551194) 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 1551194 2860525 SAR1459a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040861.1 1551024 R 282458 CDS YP_040862.1 49483638 2859304 1551500..1552126 1 NC_002952.2 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 1552126 recU 2859304 recU Staphylococcus aureus subsp. aureus MRSA252 Holliday junction-specific endonuclease YP_040862.1 1551500 D 282458 CDS YP_040863.1 49483639 2861476 1552123..1554273 1 NC_002952.2 Similar to Staphylococcus aureus penicillin-binding protein 2 Pbp2 TR:Q53729 (EMBL:X62288) (716 aa) fasta scores: E(): 0, 99.860% id in 716 aa, and to Bacillus halodurans penicillin-binding proteins 1A/1B BH1702 TR:Q9KC72 (EMBL:AP001512) (886 aa) fasta scores: E(): 2.5e-69, 35.970% id in 670 aa; penicillin-binding protein 2 1554273 pbp2 2861476 pbp2 Staphylococcus aureus subsp. aureus MRSA252 penicillin-binding protein 2 YP_040863.1 1552123 D 282458 CDS YP_040864.1 49483640 2860526 complement(1554823..1555164) 1 NC_002952.2 hypothetical protein 1555164 2860526 SAR1462 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040864.1 1554823 R 282458 CDS YP_040865.1 49483641 2860527 complement(1555169..1555828) 1 NC_002952.2 Similar to Escherichia coli endonuclease III Nth SW:END3_ECOLI (P20625) (211 aa) fasta scores: E(): 8.1e-30, 46.667% id in 210 aa. Previously sequenced as Staphylococcus aureus endonuclease-like protein TR:Q9EUT1 (EMBL:AJ132191) (220 aa) fasta scores: E(): 2e-77, 92.273% id in 220 aa; endonuclease 1555828 2860527 SAR1463 Staphylococcus aureus subsp. aureus MRSA252 endonuclease YP_040865.1 1555169 R 282458 CDS YP_040866.1 49483642 2860528 complement(1555818..1556504) 1 NC_002952.2 Similar to Bacillus subtilis DNA replication protein DnaD SW:DNAD_BACSU (P39787) (232 aa) fasta scores: E(): 1e-20, 36.792% id in 212 aa. Previously sequenced as Staphylococcus aureus DNA replication-like protein TR:Q9EUT0 (EMBL:AJ132191) (228 aa) fasta scores: E(): 6.9e-79, 99.123% id in 228 aa; hypothetical protein 1556504 2860528 SAR1464 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040866.1 1555818 R 282458 CDS YP_040867.1 49483643 2859870 complement(1556833..1558125) 1 NC_002952.2 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1558125 asnC 2859870 asnC Staphylococcus aureus subsp. aureus MRSA252 asparaginyl-tRNA synthetase YP_040867.1 1556833 R 282458 CDS YP_040868.1 49483644 2860529 complement(1558447..1561140) 1 NC_002952.2 Similar to Bacillus subtilis probable ATP-dependent helicase DinG homologue DinG SW:DING_BACSU (P54394) (931 aa) fasta scores: E(): 3.3e-39, 29.642% id in 921 aa, and to Lactococcus lactis ATP-dependent helicase DinG TR:Q9CEK5 (EMBL:AE006413) (794 aa) fasta scores: E(): 1e-29, 26.705% id in 880 aa; hypothetical protein 1561140 2860529 SAR1466 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040868.1 1558447 R 282458 CDS YP_040869.1 49483645 2858972 complement(1561164..1562135) 1 NC_002952.2 Similar to Bacillus subtilis BirA bifunctional protein [includes: biotin operon repressor; biotin--[acetyl-CoA-carboxylase] synthetase] BirA SW:BIRA_BACSU (P42975) (325 aa) fasta scores: E(): 1.1e-30, 33.435% id in 329 aa, and to Methanosarcina barkeri bifunctional biotin ligase/biotin operon repressor BirA TR:Q9HH16 (EMBL:AF317651) (326 aa) fasta scores: E(): 3.3e-30, 30.503% id in 318 aa; BirA bifunctional protein [includes: biotin operon repressor; biotin--[acetyl-CoA-carboxylase] synthetase 1562135 birA 2858972 birA Staphylococcus aureus subsp. aureus MRSA252 BirA bifunctional protein [includes: biotin operon repressor; biotin--[acetyl-CoA-carboxylase] synthetase YP_040869.1 1561164 R 282458 CDS YP_040870.1 49483646 2861475 complement(1562122..1563324) 1 NC_002952.2 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1563324 papS 2861475 papS Staphylococcus aureus subsp. aureus MRSA252 tRNA CCA-pyrophosphorylase YP_040870.1 1562122 R 282458 CDS YP_040871.1 49483647 2860530 complement(1563329..1564471) 1 NC_002952.2 Similar to Bacillus subtilis glycosyl transferase YpjH SW:YPJH_BACSU (P42982) (377 aa) fasta scores: E(): 1.4e-74, 55.676% id in 370 aa, and to Bacillus halodurans hypothetical protein BH1683 TR:Q9KC90 (EMBL:AP001512) (375 aa) fasta scores: E(): 2.1e-74, 54.839% id in 372 aa; glycosyl transferase family protein 1564471 2860530 SAR1469 Staphylococcus aureus subsp. aureus MRSA252 glycosyl transferase family protein YP_040871.1 1563329 R 282458 CDS YP_040872.1 49483648 2860531 complement(1564715..1565032) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein JBH1679 TR:Q9KC94 (EMBL:AP001512) (114 aa) fasta scores: E(): 2.7e-23, 66.019% id in 103 aa, and to Bacillus subtilis hypothetical protein JojD SW:YPJD_BACSU (P42979) (111 aa) fasta scores: E(): 1.8e-22, 62.500% id in 104 aa; hypothetical protein 1565032 2860531 SAR1470 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040872.1 1564715 R 282458 CDS YP_040873.1 49483649 2860532 complement(1565368..1566066) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1677 TR:Q9KC96 (EMBL:AP001512) (224 aa) fasta scores: E(): 3.3e-41, 55.455% id in 220 aa, and to Thermotoga maritima conserved hypothetical protein TM1511 TR:Q9X1J9 (EMBL:AE001799) (230 aa) fasta scores: E(): 4.9e-32, 46.606% id in 221 aa; hypothetical protein 1566066 2860532 SAR1471 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040873.1 1565368 R 282458 CDS YP_040874.1 49483650 2860533 complement(1566120..1566707) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpjA SW:YPJA_BACSU (P54392) (185 aa) fasta scores: E(): 1.2e-22, 41.071% id in 168 aa, and to Bacillus halodurans hypothetical protein BH1675 TR:Q9KC98 (EMBL:AP001512) (202 aa) fasta scores: E(): 4.6e-21, 43.017% id in 179 aa; hypothetical protein 1566707 2860533 SAR1472 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040874.1 1566120 R 282458 CDS YP_040875.1 49483651 2860534 complement(1566697..1567272) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1670 TR:Q9KCA3 (EMBL:AP001512) (183 aa) fasta scores: E(): 0.00015, 23.256% id in 172 aa, and to Bacillus subtilis hypothetical protein YpiB SW:YPIB_BACSU (P54390) (179 aa) fasta scores: E(): 0.0015, 24.855% id in 173 aa; hypothetical protein 1567272 2860534 SAR1473 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040875.1 1566697 R 282458 CDS YP_040876.1 49483652 2860535 complement(1567286..1568530) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpiA SW:YPIA_BACSU (P54389) (423 aa) fasta scores: E(): 5.4e-36, 31.100% id in 418 aa, and to Lactococcus lactis hypothetical protein YljJ TR:Q9CGB4 (EMBL:AE006350) (418 aa) fasta scores: E(): 5e-27, 29.639% id in 415 aa; hypothetical protein 1568530 2860535 SAR1474 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040876.1 1567286 R 282458 CDS YP_040877.1 49483653 2859860 complement(1568537..1569835) 1 NC_002952.2 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1569835 aroA 2859860 aroA Staphylococcus aureus subsp. aureus MRSA252 3-phosphoshikimate 1-carboxyvinyltransferase YP_040877.1 1568537 R 282458 CDS YP_040878.1 49483654 2859861 complement(1569845..1570909) 1 NC_002952.2 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1570909 aroB 2859861 aroB Staphylococcus aureus subsp. aureus MRSA252 3-dehydroquinate synthase YP_040878.1 1569845 R 282458 CDS YP_040879.1 49483655 2859862 complement(1570935..1572101) 1 NC_002952.2 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1572101 aroC 2859862 aroC Staphylococcus aureus subsp. aureus MRSA252 chorismate synthase YP_040879.1 1570935 R 282458 CDS YP_040880.1 49483656 2859164 complement(1572570..1573019) 1 NC_002952.2 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1573019 ndk 2859164 ndk Staphylococcus aureus subsp. aureus MRSA252 nucleoside diphosphate kinase YP_040880.1 1572570 R 282458 CDS YP_040881.1 49483657 2860536 complement(1573111..1574070) 1 NC_002952.2 Similar to Bacillus stearothermophilus heptaprenyl diphosphate synthase component II HepT SW:HEP2_BACST (P55785) (320 aa) fasta scores: E(): 4.4e-49, 44.728% id in 313 aa, and to Bacillus subtilis heptaprenyl diphosphate synthase component II HepT SW:HEP2_BACSU (P31114) (348 aa) fasta scores: E(): 8.3e-52, 46.474% id in 312 aa; heptaprenyl diphosphate synthase component II 1574070 2860536 SAR1479 Staphylococcus aureus subsp. aureus MRSA252 heptaprenyl diphosphate synthase component II YP_040881.1 1573111 R 282458 CDS YP_040882.1 49483658 2861161 complement(1574072..1574797) 1 NC_002952.2 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 1574797 ubiE 2861161 ubiE Staphylococcus aureus subsp. aureus MRSA252 ubiquinone/menaquinone biosynthesis methyltransferase YP_040882.1 1574072 R 282458 CDS YP_040883.1 49483659 2860537 complement(1574800..1575372) 1 NC_002952.2 Poor database matches. N-terminal region is similar to Micrococcus luteus component A of hexaprenyl diphosphate synthase HexS-A TR:O66127 (EMBL:AB003188) (143 aa) fasta scores: E(): 0.16, 27.407% id in 135 aa. Full length CDS is similar to internal region of Bacillus subtilis primosomal protein DnaI SW:DNAI_BACSU (P06567) (311 aa) fasta scores: E(): 0.28, 23.656% id in 186 aa; hypothetical protein 1575372 2860537 SAR1481 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040883.1 1574800 R 282458 CDS YP_040884.1 49483660 2859649 complement(1575803..1576075) 1 NC_002952.2 Similar to Bacillus stearothermophilus DNA-binding protein HU Hup SW:DBH_BACST (P02346) (90 aa) fasta scores: E(): 3.2e-24, 80.000% id in 90 aa, and to Bacillus halodurans DNA-binding protein HU-1 BH1309 SW:DBH1_BACHD (Q9KDA5) (90 aa) fasta scores: E(): 2.4e-23, 77.528% id in 89 aa; DNA-binding protein HU 1576075 hup 2859649 hup Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein HU YP_040884.1 1575803 R 282458 CDS YP_040885.1 49483661 2859939 complement(1576246..1577244) 1 NC_002952.2 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1577244 gpsA 2859939 gpsA Staphylococcus aureus subsp. aureus MRSA252 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_040885.1 1576246 R 282458 CDS YP_040886.1 49483662 2860538 complement(1577261..1578571) 1 NC_002952.2 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1578571 engA 2860538 engA Staphylococcus aureus subsp. aureus MRSA252 GTP-binding protein EngA YP_040886.1 1577261 R 282458 CDS YP_040887.1 49483663 2860032 complement(1578793..1579968) 1 NC_002952.2 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1579968 rpsA 2860032 rpsA Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S1 YP_040887.1 1578793 R 282458 CDS YP_040888.1 49483664 2859238 complement(1580680..1581339) 1 NC_002952.2 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1581339 cmk 2859238 cmk Staphylococcus aureus subsp. aureus MRSA252 cytidylate kinase YP_040888.1 1580680 R 282458 CDS YP_040889.1 49483665 2860033 1581416..1582384 1 NC_002952.2 Similar to Escherichia coli L-asparaginase II precursor AnsB SW:ASG2_ECOLI (P00805) (348 aa) fasta scores: E(): 1.4e-25, 30.120% id in 332 aa, and to Bacillus halodurans L-asparaginase BH1624 TR:Q9KCE7 (EMBL:AP001512) (322 aa) fasta scores: E(): 2.4e-61, 53.750% id in 320 aa. E. coli orthologue contains extra amino acids at the C-terminus in comparison to the CDS; L-asparaginase 1582384 2860033 SAR1487 Staphylococcus aureus subsp. aureus MRSA252 L-asparaginase YP_040889.1 1581416 D 282458 CDS YP_040890.1 49483666 2859464 complement(1582499..1583485) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1623 TR:Q9KCE8 (EMBL:AP001512) (322 aa) fasta scores: E(): 6.2e-75, 61.199% id in 317 aa, and to Bacillus subtilis hypothetical protein YpdA SW:YPDA_BACSU (P50736) (324 aa) fasta scores: E(): 7.2e-75, 63.804% id in 326 aa; pyridine nucleotide-disulfide oxidoreductase 1583485 2859464 SAR1488 Staphylococcus aureus subsp. aureus MRSA252 pyridine nucleotide-disulfide oxidoreductase YP_040890.1 1582499 R 282458 CDS YP_040891.1 49483667 2859610 complement(1583870..1585330) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus cell surface elastin binding protein EbpS TR:Q53630 (EMBL:U48826) (486 aa) fasta scores: E(): 3.5e-143, 100.000% id in 486 aa. CDS contains a polar amino acid rich region, residues 403 to 433; cell surface elastin binding protein 1585330 ebpS 2859610 ebpS Staphylococcus aureus subsp. aureus MRSA252 cell surface elastin binding protein YP_040891.1 1583870 R 282458 CDS YP_040892.1 49483668 2859465 complement(1585483..1586862) 1 NC_002952.2 Similar to the N-terminal region of Escherichia coli ATP-dependent DNA helicase RecG SW:RECQ_ECOLI (P15043) (607 aa) fasta scores: E(): 9.6e-42, 34.186% id in 430 aa, and full length Bacillus subtilis ATP-dependent DNA helicase RecQ SW:RECQ_BACSU (P50729) (496 aa) fasta scores: E(): 3.1e-53, 37.528% id in 453 aa; DEAD/DEAH box helicase 1586862 2859465 SAR1490 Staphylococcus aureus subsp. aureus MRSA252 DEAD/DEAH box helicase YP_040892.1 1585483 R 282458 CDS YP_040893.1 49483669 2859466 complement(1586852..1587805) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpbB SW:YPBB_BACSU (P50728) (352 aa) fasta scores: E(): 3.6e-08, 22.154% id in 325 aa, and to Bacillus halodurans hypothetical protein BH1606 TR:Q9KCG5 (EMBL:AP001512) (359 aa) fasta scores: E(): 0.05, 21.813% id in 353 aa; hypothetical protein 1587805 2859466 SAR1491 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040893.1 1586852 R 282458 CDS YP_040894.1 49483670 2859467 1587913..1588161 1 NC_002952.2 Similar to Bacillus thermoproteolyticus ferredoxin SW:FER_BACTH (P10245) (81 aa) fasta scores: E(): 2.7e-22, 76.250% id in 80 aa, and to Bacillus halodurans ferredoxin BH1605 TR:Q9KCG6 (EMBL:AP001512) (82 aa) fasta scores: E(): 2.3e-25, 84.146% id in 82 aa; ferredoxin 1588161 2859467 SAR1492 Staphylococcus aureus subsp. aureus MRSA252 ferredoxin YP_040894.1 1587913 D 282458 CDS YP_040895.1 49483671 2859468 complement(1588267..1588812) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpaA SW:YPAA_BACSU (P50726) (190 aa) fasta scores: E(): 1.6e-24, 46.111% id in 180 aa, and to Thermotoga maritima conserved hypothetical protein TM1455 TR:Q9X1G6 (EMBL:AE001797) (183 aa) fasta scores: E(): 3.3e-12, 34.078% id in 179 aa; hypothetical protein 1588812 2859468 SAR1493 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040895.1 1588267 R 282458 CDS YP_040896.1 49483672 2859469 complement(1589460..1590368) 1 NC_002952.2 No significant database matches. Similar to SAR1495, 73.630% identity (74.138% ungapped) in 292 aa overlap, and to SAR1566, 75.556% identity (76.923% ungapped) in 225 aa overlap; lipoprotein 1590368 2859469 SAR1494 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_040896.1 1589460 R 282458 CDS YP_040897.1 49483673 2859470 complement(1590426..1591331) 1 NC_002952.2 No significant database matches. Similar to SAR1494, 73.196% identity (73.196% ungapped) in 291 aa overlap, and to SAR1566, 74.222% identity (76.256% ungapped) in 225 aa overlap; lipoprotein 1591331 2859470 SAR1495 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_040897.1 1590426 R 282458 CDS YP_040898.1 49483674 2859471 complement(1592358..1593812) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT amidase TR:Q9B0C3 (EMBL:AB045978) (484 aa) fasta scores: E(): 3.4e-188, 97.107% id in 484 aa, and to bacteriophage phi PVL amidase TR:O80064 (EMBL:AB009866) (484 aa) fasta scores: E(): 8.7e-186, 95.248% id in 484 aa. C-terminal region is similar to SAR2037, 93.878% identity (93.878% ungapped) in 98 aa overlap; amidase 1593812 2859471 SAR1497 Staphylococcus aureus subsp. aureus MRSA252 amidase YP_040898.1 1592358 R 282458 CDS YP_040899.1 49483675 2859472 complement(1593824..1594126) 1 NC_002952.2 Highly similar to bacteriophage phi PVL holin TR:O80063 (EMBL:AB009866) (100 aa) fasta scores: E(): 1.7e-36, 99.000% id in 100 aa, and to Staphylococcus aureus temperate phage phiSLT holin TR:Q9B0C4 (EMBL:AB045978) (100 aa) fasta scores: E(): 4.3e-36, 97.000% id in 100 aa; holin 1594126 2859472 SAR1498 Staphylococcus aureus subsp. aureus MRSA252 holin YP_040899.1 1593824 R 282458 CDS YP_040900.1 49483676 2859473 complement(1594262..1594561) 1 NC_002952.2 Identical to bacteriophage phi ETA hypothetical protein Orf60 TR:Q9FZY5 (EMBL:AP001553) (99 aa) fasta scores: E(): 3.8e-31, 100.000% id in 99 aa, and similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf17 homologue TR:Q9MBN6 (EMBL:AB044554) (98 aa) fasta scores: E(): 5.2e-15, 50.515% id in 97 aa; hypothetical protein 1594561 2859473 SAR1499 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040900.1 1594262 R 282458 CDS YP_040901.1 49483677 2859474 complement(1594607..1594771) 1 NC_002952.2 Similar to bacteriophage phi ETA hypothetical protein Orf59 TR:Q9FZY6 (EMBL:AP001553) (57 aa) fasta scores: E(): 2.9e-10, 65.306% id in 49 aa, and to bacteriophage phi-105 hypothetical protein Orf44 TR:Q9ZXD9 (EMBL:AB016282) (62 aa) fasta scores: E(): 1.4, 39.535% id in 43 aa; hypothetical protein 1594771 2859474 SAR1500 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040901.1 1594607 R 282458 CDS YP_040902.1 49483678 2859475 complement(1594764..1595153) 1 NC_002952.2 Similar to bacteriophage phi ETA hypothetical protein Orf58 TR:Q9FZY7 (EMBL:AP001553) (125 aa) fasta scores: E(): 4.6e-11, 37.008% id in 127 aa; hypothetical protein 1595153 2859475 SAR1501 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040902.1 1594764 R 282458 CDS YP_040903.1 49483679 2859476 complement(1595153..1596619) 1 NC_002952.2 Similar to bacteriophage phi ETA hypothetical protein Orf57 TR:Q9FZY8 (EMBL:AP001553) (607 aa) fasta scores: E(): 4.1e-14, 26.711% id in 599 aa; hypothetical protein 1596619 2859476 SAR1502 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040903.1 1595153 R 282458 CDS YP_040904.1 49483680 2859477 complement(1596619..1598529) 1 NC_002952.2 Similar to bacteriophage phi ETA hypothetical protein Orf56 TR:Q9FZY9 (EMBL:AP001553) (632 aa) fasta scores: E(): 2.9e-105, 44.620% id in 632 aa; hypothetical protein 1598529 2859477 SAR1503 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040904.1 1596619 R 282458 CDS YP_040905.1 49483681 2859478 complement(1598545..1598835) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf96 TR:Q9B0C8 (EMBL:AB045978) (96 aa) fasta scores: E(): 3e-35, 97.917% id in 96 aa; hypothetical protein 1598835 2859478 SAR1504 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040905.1 1598545 R 282458 CDS YP_040906.1 49483682 2859479 complement(1598835..1600418) 1 NC_002952.2 Highly similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf527 TR:Q9B0C9 (EMBL:AB045978) (527 aa) fasta scores: E(): 2.1e-200, 99.810% id in 527 aa. N-terminus is similar to the N-terminal region of bacteriophage A118 hypothetical protein gp18 TR:Q9T1A5 (EMBL:AJ242593) (341 aa) fasta scores: E(): 9.5e-05, 28.814% id in 236 aa; hypothetical protein 1600418 2859479 SAR1505 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040906.1 1598835 R 282458 CDS YP_040907.1 49483683 2859480 complement(1600427..1601251) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf191 TR:Q9B0D0 (EMBL:AB045978) (191 aa) fasta scores: E(): 7.7e-70, 95.767% id in 189 aa, and to bacteriophage A118 hypothetical protein gp17 TR:Q9T1A6 (EMBL:AJ242593) (272 aa) fasta scores: E(): 5.8e-18, 29.603% id in 277 aa; hypothetical protein 1601251 2859480 SAR1506 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040907.1 1600427 R 282458 CDS YP_040908.1 49483684 2859481 complement(1601251..1607451) 1 NC_002952.2 N-terminal region is similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf1374 TR:Q9B0D2 (EMBL:AB045978) (1374 aa) fasta scores: E(): 0, 98.819% id in 1355 aa. C-terminal region is similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf588 TR:Q9B0D1 (EMBL:AB045978) (588 aa) fasta scores: E(): 5.6e-165, 96.758% id in 586 aa. Possible fusion protein. Contains coiled-coiled domain, residues 54 to 274; hypothetical protein 1607451 2859481 SAR1507 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040908.1 1601251 R 282458 CDS YP_040909.1 49483685 2859482 complement(1607465..1607623) 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 1607623 2859482 SAR1508 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040909.1 1607465 R 282458 CDS YP_040910.1 49483686 2859483 complement(1607665..1608015) 1 NC_002952.2 Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf116b TR:Q9B0D3 (EMBL:AB045978) (116 aa) fasta scores: E(): 9.4e-37, 100.000% id in 116 aa; hypothetical protein 1608015 2859483 SAR1509 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040910.1 1607665 R 282458 CDS YP_040911.1 49483687 2859484 complement(1608073..1608528) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT major tail protein TR:Q9B0D4 (EMBL:AB045978) (151 aa) fasta scores: E(): 5.9e-51, 96.026% id in 151 aa; major tail protein 1608528 2859484 SAR1510 Staphylococcus aureus subsp. aureus MRSA252 major tail protein YP_040911.1 1608073 R 282458 CDS YP_040912.1 49483688 2859485 complement(1608620..1609261) 1 NC_002952.2 Highly similar to Staphylococcus aureus temperate phage phiSLT major tail protein TR:Q9B0D5 (EMBL:AB045978) (213 aa) fasta scores: E(): 8.6e-83, 99.531% id in 213 aa; major tail protein 1609261 2859485 SAR1511 Staphylococcus aureus subsp. aureus MRSA252 major tail protein YP_040912.1 1608620 R 282458 CDS YP_040913.1 49483689 2859486 complement(1609296..1609691) 1 NC_002952.2 Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf131b TR:Q9B0D6 (EMBL:AB045978) (131 aa) fasta scores: E(): 3.3e-47, 100.000% id in 131 aa. Similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf 12 homologue TR:Q9MBP5 (EMBL:AB044554) (126 aa) fasta scores: E(): 0.56, 24.762% id in 105 aa; hypothetical protein 1609691 2859486 SAR1512 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040913.1 1609296 R 282458 CDS YP_040914.1 49483690 2859487 complement(1609692..1610063) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf123 TR:Q9B0D7 (EMBL:AB045978) (123 aa) fasta scores: E(): 4.6e-42, 95.935% id in 123 aa; hypothetical protein 1610063 2859487 SAR1513 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040914.1 1609692 R 282458 CDS YP_040915.1 49483691 2859488 complement(1610090..1610422) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf110 TR:Q9B0D8 (EMBL:AB045978) (110 aa) fasta scores: E(): 2e-41, 97.273% id in 110 aa, and to bacteriophage phi PVL hypothetical protein Orf 10 TR:O80049 (EMBL:AB009866) (111 aa) fasta scores: E(): 0.044, 30.189% id in 106 aa; hypothetical protein 1610422 2859488 SAR1514 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040915.1 1610090 R 282458 CDS YP_040916.1 49483692 2859489 complement(1610434..1610712) 1 NC_002952.2 Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf92 TR:Q9B0D9 (EMBL:AB045978) (92 aa) fasta scores: E(): 4e-37, 100.000% id in 92 aa; hypothetical protein 1610712 2859489 SAR1515 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040916.1 1610434 R 282458 CDS YP_040917.1 49483693 2859490 complement(1610781..1611944) 1 NC_002952.2 Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf387 TR:Q9B0E0 (EMBL:AB045978) (387 aa) fasta scores: E(): 4.6e-132, 100.000% id in 387 aa; hypothetical protein 1611944 2859490 SAR1516 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040917.1 1610781 R 282458 CDS YP_040918.1 49483694 2859491 complement(1611956..1612729) 1 NC_002952.2 Highly similar to Staphylococcus aureus temperate phage phiSLT protease TR:Q9B0E1 (EMBL:AB045978) (257 aa) fasta scores: E(): 7.3e-88, 99.611% id in 257 aa. Similar to Lactococcus phage BK5-T ATP-dependent ClpP protein TR:AAK56806 (EMBL:AF176025) (237 aa) fasta scores: E(): 4.4e-10, 31.250% id in 224 aa; phage protease 1612729 2859491 SAR1517 Staphylococcus aureus subsp. aureus MRSA252 phage protease YP_040918.1 1611956 R 282458 CDS YP_040919.1 49483695 2859492 complement(1612713..1613951) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT portal protein TR:Q9B0E2 (EMBL:AB045978) (412 aa) fasta scores: E(): 9.3e-154, 99.515% id in 412 aa. Similar to bacteriophage phi-105 hypothetical protein Orf25 TR:Q9ZXF8 (EMBL:AB016282) (416 aa) fasta scores: E(): 6.3e-19, 26.247% id in 381 aa; portal protein 1613951 2859492 SAR1518 Staphylococcus aureus subsp. aureus MRSA252 portal protein YP_040919.1 1612713 R 282458 CDS YP_040920.1 49483696 2859493 complement(1613956..1615656) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT terminase large subunit TR:Q9B0E3 (EMBL:AB045978) (563 aa) fasta scores: E(): 0, 96.092% id in 563 aa, and to Staphylococcus aureus prophage phiPV83 phi PVL Orf 2 homologue TR:Q9MBQ2 (EMBL:AB044554) (564 aa) fasta scores: E(): 5.9e-28, 26.740% id in 546 aa; terminase large subunit 1615656 2859493 SAR1519 Staphylococcus aureus subsp. aureus MRSA252 terminase large subunit YP_040920.1 1613956 R 282458 CDS YP_040921.1 49483697 2859494 complement(1615637..1615942) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT terminase small subunit TR:Q9B0E4 (EMBL:AB045978) (101 aa) fasta scores: E(): 1.1e-35, 98.020% id in 101 aa; terminase small subunit 1615942 2859494 SAR1520 Staphylococcus aureus subsp. aureus MRSA252 terminase small subunit YP_040921.1 1615637 R 282458 CDS YP_040922.1 49483698 2859495 complement(1616068..1616382) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf104b TR:Q9B0E5 (EMBL:AB045978) (104 aa) fasta scores: E(): 4.2e-34, 78.846% id in 104 aa, and to bacteriophage bIL285 hypothetical protein Orf39 TR:Q9AZZ0 (EMBL:AF323668) (150 aa) fasta scores: E(): 8.3e-08, 44.444% id in 72 aa; hypothetical protein 1616382 2859495 SAR1521 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040922.1 1616068 R 282458 CDS YP_040923.1 49483699 2859496 complement(1616539..1616976) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf145 TR:Q9B0E6 (EMBL:AB045978) (145 aa) fasta scores: E(): 1.1e-48, 93.793% id in 145 aa, and to bacteriophage phi-11 transcriptional activator RinA SW:RINA_BPPHA (Q03182) (140 aa) fasta scores: E(): 1, 24.476% id in 143 aa; phage regulatory protein 1616976 2859496 SAR1522 Staphylococcus aureus subsp. aureus MRSA252 phage regulatory protein YP_040923.1 1616539 R 282458 CDS YP_040924.1 49483700 2859497 complement(1616989..1618347) 1 NC_002952.2 Similar to bacteriophage APSE-1 hypothetical protein P41 SW:VP41_BPAPS (Q9T1Q7) (460 aa) fasta scores: E(): 2.9e-54, 38.126% id in 459 aa. C-terminal region is similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf116a TR:Q9B0E7 (EMBL:AB045978) (116 aa) fasta scores: E(): 1.2e-32, 94.393% id in 107 aa; hypothetical protein 1618347 2859497 SAR1523 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040924.1 1616989 R 282458 CDS YP_040925.1 49483701 2859498 complement(1618337..1618627) 1 NC_002952.2 Similar to bacteriophage APSE-1 hypothetical protein P44 SW:VP44_BPAPS (Q9T1Q4) (93 aa) fasta scores: E(): 1.5e-08, 42.857% id in 77 aa, and to Xylella fastidiosa phage-related protein XF2526 TR:Q9P9P9 (EMBL:AE004059) (92 aa) fasta scores: E(): 0.0013, 35.897% id in 78 aa; hypothetical protein 1618627 2859498 SAR1524 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040925.1 1618337 R 282458 CDS YP_040926.1 49483702 2859499 complement(1618968..1621415) 1 NC_002952.2 No significant database matches to the full length CDS. Internal region is similar to Staphylococcus aureus mobile pathogenicity island hypothetical protein Orf11 TR:O54471 (EMBL:U93688) (257 aa) fasta scores: E(): 4.2e-37, 44.758% id in 248 aa. N-terminus is similar to the N-terminal region of bacteriophage APSE-1 hypothetical protein P3 TR:Q9T1U5 (EMBL:AF157835) (752 aa) fasta scores: E(): 1.7e-20, 25.852% id in 704 aa; hypothetical protein 1621415 2859499 SAR1525 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040926.1 1618968 R 282458 CDS YP_040927.1 49483703 2859500 complement(1621468..1621668) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf66 TR:Q9B0E8 (EMBL:AB045978) (66 aa) fasta scores: E(): 1.3e-21, 98.485% id in 66 aa, and to bacteriophage phi PVL hypothetical protein Orf 60 TR:O80098 (EMBL:AB009866) (67 aa) fasta scores: E(): 6.6e-07, 44.615% id in 65 aa; exported phage protein 1621668 2859500 SAR1526 Staphylococcus aureus subsp. aureus MRSA252 exported phage protein YP_040927.1 1621468 R 282458 CDS YP_040929.1 49483705 2860605 complement(1621736..1621888) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 57 homologue TR:Q9B0E9 (EMBL:AB045978) (51 aa) fasta scores: E(): 2.2e-20, 98.039% id in 51 aa, and to bacteriophage phi ETA hypothetical protein Orf37 TR:Q9G008 (EMBL:AP001553) (57 aa) fasta scores: E(): 2.6e-15, 80.357% id in 56 aa. Similar to SAR2069, 87.755% identity (89.583% ungapped) in 49 aa overlap; hypothetical protein 1621888 2860605 SAR1527 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040929.1 1621736 R 282458 CDS YP_040930.1 49483706 2860606 complement(1621881..1622117) 1 NC_002952.2 Identical to Staphylococcus aureus prophage phiPV83 and temperate phage phiSLT hypothetical protein Orf 30 (Orf78) TR:Q9MBQ9 (EMBL:AB044554) (78 aa) fasta scores: E(): 1.3e-29, 100.000% id in 78 aa; hypothetical protein 1622117 2860606 SAR1528 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040930.1 1621881 R 282458 CDS YP_040931.1 49483707 2860607 complement(1622142..1622378) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf77 TR:Q9B0F0 (EMBL:AB045978) (77 aa) fasta scores: E(): 1.3e-24, 88.158% id in 76 aa, and to bacteriophage phi PVL hypothetical protein Orf 55 TR:O80093 (EMBL:AB009866) (62 aa) fasta scores: E(): 4.6e-13, 85.106% id in 47 aa. Similar to SAR2071, 78.723% identity (78.723% ungapped) in 47 aa overlap; hypothetical protein 1622378 2860607 SAR1529 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040931.1 1622142 R 282458 CDS YP_040932.1 49483708 2860608 complement(1622395..1622568) 1 NC_002952.2 hypothetical protein 1622568 2860608 SAR1530 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040932.1 1622395 R 282458 CDS YP_040933.1 49483709 2860609 complement(1622605..1623141) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 29 TR:Q9MBR0 (EMBL:AB044554) (178 aa) fasta scores: E(): 4.9e-65, 96.629% id in 178 aa, and to bacteriophage phi ETA hypothetical protein Orf34 TR:Q9G011 (EMBL:AP001553) (178 aa) fasta scores: E(): 5.4e-31, 55.191% id in 183 aa; hypothetical protein 1623141 2860609 SAR1531 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040933.1 1622605 R 282458 CDS YP_040934.1 49483710 2860610 complement(1623134..1623382) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 52 homologue TR:Q9B0F3 (EMBL:AB045978) (82 aa) fasta scores: E(): 5.8e-27, 96.341% id in 82 aa, and to bacteriophage phi PVL hypothetical protein Orf 52 TR:O80090 (EMBL:AB009866) (82 aa) fasta scores: E(): 1.4e-25, 93.902% id in 82 aa. Similar to SAR2074, 82.927% identity (82.927% ungapped) in 82 aa overlap; hypothetical protein 1623382 2860610 SAR1532 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040934.1 1623134 R 282458 CDS YP_040935.1 49483711 2860611 complement(1623375..1623806) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 27 TR:Q9MBR2 (EMBL:AB044554) (96 aa) fasta scores: E(): 0.013, 48.214% id in 56 aa, and to bacteriophage phi ETA hypothetical protein Orf31 TR:Q9G014 (EMBL:AP001553) (94 aa) fasta scores: E(): 0.028, 46.429% id in 56 aa. Contains coiled-coiled domain, residues 48 to 68; hypothetical protein 1623806 2860611 SAR1533 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040935.1 1623375 R 282458 CDS YP_040936.1 49483712 2860612 complement(1623806..1623997) 1 NC_002952.2 hypothetical protein 1623997 2860612 SAR1534 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040936.1 1623806 R 282458 CDS YP_040937.1 49483713 2860613 complement(1623994..1624386) 1 NC_002952.2 No significant database matches to the full length CDS. C-terminus is similar to the C-terminal region of bacteriophage phi ETA hypothetical protein Orf30 TR:Q9G015 (EMBL:AP001553) (50 aa) fasta scores: E(): 0.027, 82.609% id in 23 aa; hypothetical protein 1624386 2860613 SAR1535 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040937.1 1623994 R 282458 CDS YP_040938.1 49483714 2860614 complement(1624401..1624643) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 51 homologue TR:Q9B0F4 (EMBL:AB045978) (80 aa) fasta scores: E(): 7e-25, 83.750% id in 80 aa, and to Staphylococcus aureus prophage phiPV83 phi PVL Orf 51 homologue TR:Q9MBR3 (EMBL:AB044554) (82 aa) fasta scores: E(): 2.6e-24, 84.810% id in 79 aa. Similar to SAR2076, 82.500% identity (82.500% ungapped) in 80 aa overlap; hypothetical protein 1624643 2860614 SAR1536 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040938.1 1624401 R 282458 CDS YP_040939.1 49483715 2860615 complement(1624658..1624858) 1 NC_002952.2 Similar to bacteriophage phi ETA hypothetical protein Orf28 TR:Q9G017 (EMBL:AP001553) (56 aa) fasta scores: E(): 1.5e-19, 96.429% id in 56 aa. CDS is extended at the N-terminus in comparison to the bacteriophage phi ETA orthologue. Possible alternative translational start site; hypothetical protein 1624858 2860615 SAR1537 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040939.1 1624658 R 282458 CDS YP_040940.1 49483716 2860616 complement(1624861..1625118) 1 NC_002952.2 Similar to the C-terminal regions of bacteriophage T7 1.7 protein SW:V17_BPT7 (P03781) (196 aa) fasta scores: E(): 0.73, 37.143% id in 70 aa, and bacteriophage phiYeO3-12 1.7 protein TR:Q9T137 (EMBL:AJ251805) (156 aa) fasta scores: E(): 1.3, 29.412% id in 85 aa; hypothetical protein 1625118 2860616 SAR1538 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040940.1 1624861 R 282458 CDS YP_040941.1 49483717 2860617 complement(1625118..1625519) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf 50 TR:Q9MBR4 (EMBL:AB044554) (123 aa) fasta scores: E(): 1.7e-07, 36.029% id in 136 aa; DNA-binding protein 1625519 2860617 SAR1539 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_040941.1 1625118 R 282458 CDS YP_040942.1 49483718 2860618 complement(1625519..1625704) 1 NC_002952.2 Similar to bacteriophage phi ETA hypothetical protein Orf26 TR:Q9G019 (EMBL:AP001553) (61 aa) fasta scores: E(): 4.4e-13, 60.656% id in 61 aa, and to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 23 TR:Q9MBR6 (EMBL:AB044554) (61 aa) fasta scores: E(): 2.5e-09, 55.738% id in 61 aa; hypothetical protein 1625704 2860618 SAR1540 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040942.1 1625519 R 282458 CDS YP_040943.1 49483719 2860619 complement(1625717..1627678) 1 NC_002952.2 Similar to bacteriophage SP02 DNA polymerase L SW:DPOL_BPSP2 (P06225) (648 aa) fasta scores: E(): 6.5e-134, 54.103% id in 658 aa, and to the N-terminal region of bacteriophage APSE-1 probable DNA polymerase 45 SW:DPOL_BPAPS (Q9T1Q3) (993 aa) fasta scores: E(): 1e-34, 29.363% id in 722 aa; DNA polymerase 1627678 2860619 SAR1541 Staphylococcus aureus subsp. aureus MRSA252 DNA polymerase YP_040943.1 1625717 R 282458 CDS YP_040944.1 49483720 2860620 complement(1627737..1628294) 1 NC_002952.2 Similar to bacteriophage APSE-1 hypothetical protein P50 SW:VP50_BPAPS (Q9T1P8) (184 aa) fasta scores: E(): 3.2e-10, 30.055% id in 183 aa. CDS is extended at the N-terminus in comparison to the bacteriophage APSE-1 protein. Possible alternative translational start site; hypothetical protein 1628294 2860620 SAR1542 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040944.1 1627737 R 282458 CDS YP_040945.1 49483721 2860621 complement(1628320..1629486) 1 NC_002952.2 Similar to bacteriophage APSE-1 hypothetical protein P51 SW:VP51_BPAPS (Q9T1P7) (439 aa) fasta scores: E(): 1.2e-16, 31.925% id in 426 aa, and to Xylella fastidiosa phage-related protein XF2522 TR:Q9PAJ4 (EMBL:AE004059) (425 aa) fasta scores: E(): 1.8e-06, 29.594% id in 419 aa; hypothetical protein 1629486 2860621 SAR1543 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040945.1 1628320 R 282458 CDS YP_040946.1 49483722 2860622 complement(1629483..1629845) 1 NC_002952.2 hypothetical protein 1629845 2860622 SAR1544 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040946.1 1629483 R 282458 CDS YP_040947.1 49483723 2860623 complement(1629860..1630183) 1 NC_002952.2 hypothetical protein 1630183 2860623 SAR1545 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040947.1 1629860 R 282458 CDS YP_040948.1 49483724 2860624 complement(1630262..1630423) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 38 homologue TR:Q9B0G7 (EMBL:AB045978) (53 aa) fasta scores: E(): 3.3e-20, 96.226% id in 53 aa, and to bacteriophage phi PVL hypothetical protein Orf 38 TR:O80077 (EMBL:AB009866) (53 aa) fasta scores: E(): 6.9e-20, 96.226% id in 53 aa. Similar to SAR2091, 92.453% identity (92.453% ungapped) in 53 aa overlap; hypothetical protein 1630423 2860624 SAR1546 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040948.1 1630262 R 282458 CDS YP_040949.1 49483725 2860625 complement(1630436..1630699) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 37 TR:O80076 (EMBL:AB009866) (87 aa) fasta scores: E(): 2.9e-34, 96.552% id in 87 aa, and to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 37 homologue TR:Q9B0G8 (EMBL:AB045978) (87 aa) fasta scores: E(): 7.7e-33, 93.103% id in 87 aa; DNA-binding protein 1630699 2860625 SAR1547 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_040949.1 1630436 R 282458 CDS YP_040950.1 49483726 2860626 complement(1630726..1630941) 1 NC_002952.2 Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf71 TR:Q9B0G9 (EMBL:AB045978) (71 aa) fasta scores: E(): 1.3e-25, 100.000% id in 71 aa; hypothetical protein 1630941 2860626 SAR1548 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040950.1 1630726 R 282458 CDS YP_040951.1 49483727 2861153 1630996..1631361 1 NC_002952.2 Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf121 TR:Q9B0H0 (EMBL:AB045978) (121 aa) fasta scores: E(): 2.1e-43, 100.000% id in 121 aa; hypothetical protein 1631361 2861153 SAR1549 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040951.1 1630996 D 282458 CDS YP_040952.1 49483728 2859103 complement(1631330..1631575) 1 NC_002952.2 hypothetical protein 1631575 2859103 SAR1550 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040952.1 1631330 R 282458 CDS YP_040953.1 49483729 2859104 1631642..1632022 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 36 TR:Q9T1Z5 (EMBL:AB009866) (126 aa) fasta scores: E(): 7.1e-35, 69.841% id in 126 aa; hypothetical protein 1632022 2859104 SAR1551 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040953.1 1631642 D 282458 CDS YP_040954.1 49483730 2859105 complement(1632009..1632206) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 35 TR:O80075 (EMBL:AB009866) (65 aa) fasta scores: E(): 7.6e-17, 67.692% id in 65 aa. Similar to SAR2095, 67.692% identity (67.692% ungapped) in 65 aa overlap; hypothetical protein 1632206 2859105 SAR1552 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040954.1 1632009 R 282458 CDS YP_040955.1 49483731 2859106 complement(1632529..1632678) 1 NC_002952.2 hypothetical protein 1632678 2859106 SAR1553 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040955.1 1632529 R 282458 CDS YP_040956.1 49483732 2859107 complement(1632693..1633136) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 7 TR:Q9MBT2 (EMBL:AB044554) (147 aa) fasta scores: E(): 2.6e-50, 97.959% id in 147 aa; hypothetical protein 1633136 2859107 SAR1554 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040956.1 1632693 R 282458 CDS YP_040957.1 49483733 2859108 complement(1633154..1633378) 1 NC_002952.2 Similar to Lactococcus bacteriophage phi31 Cro repressor TR:Q9G0E7 (EMBL:AJ292531) (74 aa) fasta scores: E(): 1.3e-12, 58.333% id in 72 aa, and to bacteriophage TP901-1, and bacteriophage bIL285, modulator of repressor protein Mor TR:O48504 (EMBL:Y14232) (72 aa) fasta scores: E(): 1.4e-13, 55.556% id in 72 aa; regulatory protein 1633378 2859108 SAR1555 Staphylococcus aureus subsp. aureus MRSA252 regulatory protein YP_040957.1 1633154 R 282458 CDS YP_040958.1 49483734 2859109 1633540..1633920 1 NC_002952.2 N-terminus is similar to the N-terminal regions of bacteriophage phi PVL repressor TR:O80070 (EMBL:AB009866) (256 aa) fasta scores: E(): 1.8e-14, 47.368% id in 114 aa, and to bacteriophage bIL285 repressor Orf4 TR:Q9B013 (EMBL:AF323668) (180 aa) fasta scores: E(): 4.5e-11, 51.724% id in 87 aa; regulatory protein 1633920 2859109 SAR1556 Staphylococcus aureus subsp. aureus MRSA252 regulatory protein YP_040958.1 1633540 D 282458 CDS YP_040959.1 49483735 2859110 1633942..1634400 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf153 TR:Q9B0H5 (EMBL:AB045978) (153 aa) fasta scores: E(): 1.4e-41, 75.817% id in 153 aa, and to bacteriophage A118 gp35 TR:Q9T189 (EMBL:AJ242593) (163 aa) fasta scores: E(): 6e-08, 31.008% id in 129 aa; hypothetical protein 1634400 2859110 SAR1557 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040959.1 1633942 D 282458 CDS YP_040960.1 49483736 2859111 1634418..1634852 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf144 TR:Q9B0H6 (EMBL:AB045978) (144 aa) fasta scores: E(): 1.2e-42, 98.611% id in 144 aa; lipoprotein 1634852 2859111 SAR1558 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_040960.1 1634418 D 282458 CDS YP_040961.1 49483737 2859112 1634881..1635276 1 NC_002952.2 Highly similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf131a TR:Q9B0H7 (EMBL:AB045978) (131 aa) fasta scores: E(): 7.6e-51, 99.237% id in 131 aa, and to the C-terminal region of Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 3 TR:Q9MBT6 (EMBL:AB044554) (149 aa) fasta scores: E(): 7.7e-48, 94.656% id in 131 aa; hypothetical protein 1635276 2859112 SAR1559 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040961.1 1634881 D 282458 CDS YP_040962.1 49483738 2859113 1635366..1635488 1 NC_002952.2 hypothetical protein 1635488 2859113 SAR1560 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040962.1 1635366 D 282458 CDS YP_040963.1 49483739 2859114 complement(1635475..1636098) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 30 TR:O80069 (EMBL:AB009866) (204 aa) fasta scores: E(): 3.1e-05, 28.986% id in 207 aa, and to Staphylococcus aureus temperate phage phiSLT phi PVL orf 30 homologue TR:Q9B0H8 (EMBL:AB045978) (204 aa) fasta scores: E(): 2.7e-05, 28.986% id in 207 aa; hypothetical protein 1636098 2859114 SAR1561 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040963.1 1635475 R 282458 CDS YP_040964.1 49483740 2859115 1636208..1637413 1 NC_002952.2 Similar to bacteriophage phi PVL and temperate phage phiSLT integrase TR:O80068 (EMBL:AB009866) (401 aa) fasta scores: E(): 7.8e-138, 99.751% id in 401 aa, and to the C-terminal region of bacteriophage L54a excisionase Xis SW:VINT_BPL54 (P20709) (354 aa) fasta scores: E(): 9.5e-89, 73.580% id in 352 aa; phage integrase 1637413 2859115 SAR1562 Staphylococcus aureus subsp. aureus MRSA252 phage integrase YP_040964.1 1636208 D 282458 CDS YP_040965.1 49483741 2859501 complement(1640667..1642433) 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Previously sequenced as Staphylococcus aureus staphylococcal respiratory response protein (histidine kinase) SrrB TR:Q9L523 (EMBL:AF260326) (583 aa) fasta scores: E(): 2.7e-205, 99.828% id in 583 aa. Similar to Bacillus subtilis sensor protein ResE SW:RESE_BACSU (P35164) (589 aa) fasta scores: E(): 1.4e-59, 33.893% id in 596 aa. Possible alternative translational start site; sensor kinase 1642433 srrB 2859501 srrB Staphylococcus aureus subsp. aureus MRSA252 sensor kinase YP_040965.1 1640667 R 282458 CDS YP_040966.1 49483742 2859161 complement(1642399..1643142) 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Previously sequenced as Staphylococcus aureus staphylococcal respiratory response protein SrrA TR:Q9L524 (EMBL:AF260326) (241 aa) fasta scores: E(): 3.1e-92, 100.000% id in 241 aa. Similar to Bacillus halodurans two-component response regulator BH1580 TR:Q9KCJ1 (EMBL:AP001512) (238 aa) fasta scores: E(): 1.7e-64, 73.043% id in 230 aa; response regulator protein 1643142 srrA 2859161 srrA Staphylococcus aureus subsp. aureus MRSA252 response regulator protein YP_040966.1 1642399 R 282458 CDS YP_040967.1 49483743 2859275 complement(1643257..1643994) 1 NC_002952.2 Similar to Bacillus subtilis ribosomal large subunit pseudouridine synthase B RluB SW:RLUB_BACSU (P35159) (229 aa) fasta scores: E(): 1.6e-47, 60.444% id in 225 aa, and to Bacillus halodurans pseudouridylate synthase BH1576 TR:Q9KCJ5 (EMBL:AP001512) (242 aa) fasta scores: E(): 2e-48, 60.084% id in 238 aa; ribosomal large subunit pseudouridine synthase B 1643994 rluB 2859275 rluB Staphylococcus aureus subsp. aureus MRSA252 ribosomal large subunit pseudouridine synthase B YP_040967.1 1643257 R 282458 CDS YP_040968.1 49483744 2859118 complement(1643987..1644529) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpuH SW:YPUH_BACSU (P35155) (197 aa) fasta scores: E(): 4.4e-16, 38.503% id in 187 aa, and to Bacillus halodurans hypothetical protein BH1561 TR:Q9KCL0 (EMBL:AP001512) (197 aa) fasta scores: E(): 1.5e-12, 34.078% id in 179 aa; hypothetical protein 1644529 2859118 SAR1570 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040968.1 1643987 R 282458 CDS YP_040969.1 49483745 2860823 complement(1644522..1645277) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpuG SW:YPUG_BACSU (P35154) (251 aa) fasta scores: E(): 1.4e-32, 43.145% id in 248 aa, and to Bacillus halodurans hypothetical protein BH1560 TR:Q9KCL1 (EMBL:AP001512) (260 aa) fasta scores: E(): 1.6e-28, 42.683% id in 246 aa. Possible alternative translation start site; hypothetical protein 1645277 2860823 SAR1571 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040969.1 1644522 R 282458 CDS YP_040970.1 49483746 2860824 1645345..1645851 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpuF SW:YPUF_BACSU (P17617) (174 aa) fasta scores: E(): 1e-12, 31.977% id in 172 aa, and to Bacillus halodurans hypothetical protein BH1559 TR:Q9KCL2 (EMBL:AP001512) (178 aa) fasta scores: E(): 7.7e-09, 27.647% id in 170 aa; hypothetical protein 1645851 2860824 SAR1572 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040970.1 1645345 D 282458 CDS YP_040971.1 49483747 2860431 complement(1645929..1646816) 1 NC_002952.2 Similar to Escherichia coli integrase/recombinase XerD SW:XERD_ECOLI (P21891) (298 aa) fasta scores: E(): 4.3e-44, 44.178% id in 292 aa. Previously sequenced as Staphylococcus aureus site-specific recombinase XerD TR:Q9KJF7 (EMBL:AF173869) (295 aa) fasta scores: E(): 1.6e-109, 98.299% id in 294 aa; integrase/recombinase 1646816 xerD 2860431 xerD Staphylococcus aureus subsp. aureus MRSA252 integrase/recombinase YP_040971.1 1645929 R 282458 CDS YP_040972.1 49483748 2860686 complement(1646865..1647314) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus iron uptake regulatory protein Fur TR:Q9R303 (EMBL:AF118839) (149 aa) fasta scores: E(): 2.1e-56, 99.329% id in 149 aa. Similar to Bacillus subtilis ferric uptake regulation protein fur SW:FUR_BACSU (P54574) (149 aa) fasta scores: E(): 2.2e-41, 75.342% id in 146 aa; iron uptake regulatory protein 1647314 fur 2860686 fur Staphylococcus aureus subsp. aureus MRSA252 iron uptake regulatory protein YP_040972.1 1646865 R 282458 CDS YP_040973.1 49483749 2860825 complement(1647419..1647961) 1 NC_002952.2 Similar to Bacillus subtilis ADP-ribose pyrophosphatase NudF SW:ADPP_BACSU (P54570) (185 aa) fasta scores: E(): 5.4e-26, 48.851% id in 174 aa, and to Bacillus halodurans BH1524 TR:Q9KCP5 (EMBL:AP001512) (183 aa) fasta scores: E(): 3.1e-28, 52.907% id in 172 aa; ADP-ribose pyrophosphatase 1647961 2860825 SAR1575 Staphylococcus aureus subsp. aureus MRSA252 ADP-ribose pyrophosphatase YP_040973.1 1647419 R 282458 CDS YP_040974.1 49483750 2860826 1648043..1648951 1 NC_002952.2 Similar to Bacillus subtilis hypothetical oxidoreductase YqkF SW:YQKF_BACSU (P54569) (306 aa) fasta scores: E(): 1.3e-45, 48.852% id in 305 aa, and to Bacillus halodurans oxidoreductase BH1011 TR:Q9KE47 (EMBL:AP001510) (297 aa) fasta scores: E(): 1.5e-44, 49.342% id in 304 aa; aldo/keto reductase 1648951 2860826 SAR1576 Staphylococcus aureus subsp. aureus MRSA252 aldo/keto reductase YP_040974.1 1648043 D 282458 CDS YP_040975.1 49483751 2860827 complement(1649167..1649415) 1 NC_002952.2 hypothetical protein 1649415 2860827 SAR1577 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040975.1 1649167 R 282458 CDS YP_040976.1 49483752 2860828 complement(1649431..1650189) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical oxidoreductase YqjQ SW:YQJQ_BACSU (P54554) (259 aa) fasta scores: E(): 2.1e-17, 29.839% id in 248 aa, and to Bacillus halodurans oxidoreductase BH1506 TR:Q9KCR3 (EMBL:AP001512) (259 aa) fasta scores: E(): 7.1e-16, 30.000% id in 260 aa; short chain dehydrogenase 1650189 2860828 SAR1578 Staphylococcus aureus subsp. aureus MRSA252 short chain dehydrogenase YP_040976.1 1649431 R 282458 CDS YP_040977.1 49483753 2860829 1650328..1651143 1 NC_002952.2 Similar to Bacillus subtilis pyrroline-5-carboxylate reductase 2 proI SW:PROI_BACSU (P54552) (278 aa) fasta scores: E(): 4.2e-23, 35.294% id in 255 aa, and to Bacillus subtilis pyrroline-5-carboxylate reductase 1 ProH SW:PROH_BACSU (P14383) (270 aa) fasta scores: E(): 3.1e-20, 32.636% id in 239 aa; pyrroline-5-carboxylate reductase 1651143 2860829 SAR1579 Staphylococcus aureus subsp. aureus MRSA252 pyrroline-5-carboxylate reductase YP_040977.1 1650328 D 282458 CDS YP_040978.1 49483754 2860830 complement(1651248..1652168) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqjK SW:YQJK_BACSU (P54548) (307 aa) fasta scores: E(): 6.8e-47, 43.046% id in 302 aa, and to Bacillus halodurans hypothetical protein BH1713 TR:Q9KC61 (EMBL:AP001512) (309 aa) fasta scores: E(): 4.4e-45, 42.532% id in 308 aa; hypothetical protein 1652168 2860830 SAR1581 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040978.1 1651248 R 282458 CDS YP_040979.1 49483755 2859634 1652481..1653965 1 NC_002952.2 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1653965 zwf 2859634 zwf Staphylococcus aureus subsp. aureus MRSA252 glucose-6-phosphate 1-dehydrogenase YP_040979.1 1652481 D 282458 CDS YP_040980.1 49483756 2860831 1654195..1655061 1 NC_002952.2 Similar to Bacillus subtilis probable transcriptional regulator (AraC/XylS family) YdeE TR:P96662 (EMBL:AB001488) (290 aa) fasta scores: E(): 4.7e-16, 26.117% id in 291 aa, and to Lactococcus lactis hypothetical protein TR:O32788 (EMBL:X92946) (281 aa) fasta scores: E(): 1.4e-13, 27.211% id in 294 aa; AraC family transcription regulator 1655061 2860831 SAR1583 Staphylococcus aureus subsp. aureus MRSA252 AraC family transcription regulator YP_040980.1 1654195 D 282458 CDS YP_040981.1 49483757 2861155 complement(1655144..1656793) 1 NC_002952.2 Similar to Staphylococcus xylosus alpha-D-1,4-glucosidase MalA TR:Q60015 (EMBL:X78853) (549 aa) fasta scores: E(): 1.2e-181, 79.342% id in 547 aa, and to Bacillus halodurans exo-alpha-1,4-glucosidase BH3868 TR:Q9K664 (EMBL:AP001520) (553 aa) fasta scores: E(): 2.5e-141, 62.774% id in 548 aa; alpha-D-1,4-glucosidase 1656793 malA 2861155 malA Staphylococcus aureus subsp. aureus MRSA252 alpha-D-1,4-glucosidase YP_040981.1 1655144 R 282458 CDS YP_040982.1 49483758 2861156 complement(1656809..1657828) 1 NC_002952.2 Similar to Staphylococcus xylosus maltose operon transcriptional repressor MalR SW:MALR_STAXY (Q56201) (337 aa) fasta scores: E(): 1.5e-46, 44.083% id in 338 aa, and to Streptococcus pyogenes maltose operon transcriptional repressor SPY1293 TR:Q99ZC1 (EMBL:AE006568) (339 aa) fasta scores: E(): 1.3e-30, 32.059% id in 340 aa; maltose operon transcriptional repressor 1657828 malR 2861156 malR Staphylococcus aureus subsp. aureus MRSA252 maltose operon transcriptional repressor YP_040982.1 1656809 R 282458 CDS YP_040983.1 49483759 2860832 complement(1658022..1658393) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YfhJ TR:Q9CHY4 (EMBL:AE006292) (122 aa) fasta scores: E(): 4.8e-09, 38.596% id in 114 aa, and to Bacillus subtilis hypothetical protein YetH TR:O31535 (EMBL:Z99107) (120 aa) fasta scores: E(): 0.00015, 30.400% id in 125 aa; glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein 1658393 2860832 SAR1586 Staphylococcus aureus subsp. aureus MRSA252 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein YP_040983.1 1658022 R 282458 CDS YP_040984.1 49483760 2860833 complement(1658869..1659768) 1 NC_002952.2 Similar to Exiguobacterium acetylicum guanosine kinase Gsk TR:O24767 (EMBL:AB005149) (303 aa) fasta scores: E(): 2.5e-09, 22.449% id in 294 aa, and to Escherichia coli hypothetical sugar kinase YeiC SW:YEIC_ECOLI (P30235) (313 aa) fasta scores: E(): 5.7e-19, 29.352% id in 293 aa; PfkB family carbohydrate kinase 1659768 2860833 SAR1587 Staphylococcus aureus subsp. aureus MRSA252 PfkB family carbohydrate kinase YP_040984.1 1658869 R 282458 CDS YP_040985.1 49483761 2859935 complement(1661312..1662718) 1 NC_002952.2 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 1662718 gnd 2859935 gnd Staphylococcus aureus subsp. aureus MRSA252 6-phosphogluconate dehydrogenase YP_040985.1 1661312 R 282458 CDS YP_040986.1 49483762 2860835 complement(1662786..1663919) 1 NC_002952.2 Similar to Salmonella typhimurium peptidase T PepT SW:PEPT_SALTY (P26311) (409 aa) fasta scores: E(): 3.9e-14, 24.757% id in 412 aa, and to Bacillus halodurans hypothetical protein BH1469 TR:Q9KCV0 (EMBL:AP001512) (372 aa) fasta scores: E(): 4.8e-72, 56.604% id in 371 aa; peptidase 1663919 2860835 SAR1590 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_040986.1 1662786 R 282458 CDS YP_040987.1 49483763 2860836 complement(1664488..1665468) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqjA SW:YQJA_BACSU (P54538) (322 aa) fasta scores: E(): 1.3e-39, 39.683% id in 315 aa, and to Bacillus halodurans hypothetical protein BH1464 TR:Q9KCV5 (EMBL:AP001512) (326 aa) fasta scores: E(): 6.3e-34, 36.156% id in 307 aa; hypothetical protein 1665468 2860836 SAR1591 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040987.1 1664488 R 282458 CDS YP_040988.1 49483764 2860837 complement(1665482..1665919) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqiW SW:YQIW_BACSU (P54534) (145 aa) fasta scores: E(): 4.7e-38, 68.056% id in 144 aa, and to Bacillus halodurans hypothetical protein BH2759 TR:Q9K991 (EMBL:AP001516) (145 aa) fasta scores: E(): 3.8e-35, 65.714% id in 140 aa; hypothetical protein 1665919 2860837 SAR1592 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040988.1 1665482 R 282458 CDS YP_040989.1 49483765 2859886 complement(1666269..1667543) 1 NC_002952.2 Similar to Bacillus subtilis lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex BfmB SW:ODB2_BACSU (P37942) (424 aa) fasta scores: E(): 4.5e-80, 55.220% id in 431 aa, and to Bacillus halodurans branched-chain alpha-keto acid dehydrogenase E2 BH2761 TR:Q9K989 (EMBL:AP001516) (426 aa) fasta scores: E(): 3.4e-80, 55.172% id in 435 aa; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 1667543 bfmB 2859886 bfmB Staphylococcus aureus subsp. aureus MRSA252 lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex YP_040989.1 1666269 R 282458 CDS YP_040990.1 49483766 2858967 complement(1667556..1668539) 1 NC_002952.2 Similar to Bacillus subtilis 2-oxoisovalerate dehydrogenase beta subunit BfmBAB SW:ODBB_BACSU (P37941) (327 aa) fasta scores: E(): 4e-89, 66.972% id in 327 aa, and to Bacillus halodurans branched-chain alpha-keto acid dehydrogenase E1 BH2762 TR:Q9K988 (EMBL:AP001516) (327 aa) fasta scores: E(): 7.8e-91, 67.278% id in 327 aa; 2-oxoisovalerate dehydrogenase subunit beta 1668539 bfmBAB 2858967 bfmBAB Staphylococcus aureus subsp. aureus MRSA252 2-oxoisovalerate dehydrogenase subunit beta YP_040990.1 1667556 R 282458 CDS YP_040991.1 49483767 2858966 complement(1668539..1669531) 1 NC_002952.2 Similar to Bacillus subtilis 2-oxoisovalerate dehydrogenase alpha subunit BfmBAA SW:ODBA_BACSU (P37940) (330 aa) fasta scores: E(): 1.4e-60, 53.251% id in 323 aa, and to Bacillus halodurans branched-chain alpha-keto acid dehydrogenase E1 BH2763 TR:Q9K987 (EMBL:AP001516) (330 aa) fasta scores: E(): 1.8e-63, 56.000% id in 325 aa; 2-oxoisovalerate dehydrogenase subunit alpha 1669531 bfmBAA 2858966 bfmBAA Staphylococcus aureus subsp. aureus MRSA252 2-oxoisovalerate dehydrogenase subunit alpha YP_040991.1 1668539 R 282458 CDS YP_040992.1 49483768 2858968 complement(1669547..1670968) 1 NC_002952.2 Similar to Bacillus subtilis dihydrolipoamide dehydrogenase BfmBC SW:DLD2_BACSU (P54533) (474 aa) fasta scores: E(): 3.4e-80, 48.842% id in 475 aa, and to Bacillus halodurans dihydrolipoamide dehydrogenase BH2764 TR:Q9K986 (EMBL:AP001516) (474 aa) fasta scores: E(): 4.5e-80, 48.745% id in 478 aa; dihydrolipoamide dehydrogenase 1670968 bfmBC 2858968 bfmBC Staphylococcus aureus subsp. aureus MRSA252 dihydrolipoamide dehydrogenase YP_040992.1 1669547 R 282458 CDS YP_040993.1 49483769 2860838 complement(1671119..1672798) 1 NC_002952.2 Similar to Escherichia coli DNA repair protein RecN SW:RECN_ECOLI (P05824) (553 aa) fasta scores: E(): 2.7e-41, 33.989% id in 559 aa, and to Bacillus halodurans DNA repair protein BH2776 SW:RECN_BACHD (Q9K974) (565 aa) fasta scores: E(): 3.3e-62, 41.547% id in 556 aa; DNA repair protein 1672798 2860838 SAR1597 Staphylococcus aureus subsp. aureus MRSA252 DNA repair protein YP_040993.1 1671119 R 282458 CDS YP_040994.1 49483770 2859856 complement(1672814..1673266) 1 NC_002952.2 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 1673266 argR 2859856 argR Staphylococcus aureus subsp. aureus MRSA252 arginine repressor YP_040994.1 1672814 R 282458 CDS YP_040995.1 49483771 2860839 complement(1673697..1674578) 1 NC_002952.2 Similar to Bacillus stearothermophilus geranyltranstransferase SW:ISPA_BACST (Q08291) (297 aa) fasta scores: E(): 1e-46, 47.492% id in 299 aa, and to Bacillus halodurans geranyltranstransferase BH2781 TR:Q9K969 (EMBL:AP001516) (294 aa) fasta scores: E(): 3.2e-46, 47.222% id in 288 aa; geranyltranstransferase 1674578 2860839 SAR1599 Staphylococcus aureus subsp. aureus MRSA252 geranyltranstransferase YP_040995.1 1673697 R 282458 CDS YP_040996.1 49483772 2860840 complement(1674556..1674786) 1 NC_002952.2 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1674786 2860840 SAR1600 Staphylococcus aureus subsp. aureus MRSA252 exodeoxyribonuclease VII small subunit YP_040996.1 1674556 R 282458 CDS YP_040997.1 49483773 2860841 complement(1674779..1676116) 1 NC_002952.2 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1676116 xseA 2860841 xseA Staphylococcus aureus subsp. aureus MRSA252 exodeoxyribonuclease VII large subunit YP_040997.1 1674779 R 282458 CDS YP_040998.1 49483774 2860842 complement(1676133..1676522) 1 NC_002952.2 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 1676522 nusB 2860842 nusB Staphylococcus aureus subsp. aureus MRSA252 transcription antitermination protein NusB YP_040998.1 1676133 R 282458 CDS YP_040999.1 49483775 2860843 complement(1676582..1676944) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqhY SW:YQHY_BACSU (P54519) (135 aa) fasta scores: E(): 6.7e-13, 42.342% id in 111 aa, and to Bacillus halodurans hypothetical protein BH2786 TR:Q9K964 (EMBL:AP001516) (132 aa) fasta scores: E(): 2.9e-11, 40.000% id in 110 aa; hypothetical protein 1676944 2860843 SAR1603 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_040999.1 1676582 R 282458 CDS YP_041000.1 49483776 2859054 complement(1676959..1678314) 1 NC_002952.2 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 1678314 accC 2859054 accC Staphylococcus aureus subsp. aureus MRSA252 acetyl-CoA carboxylase biotin carboxylase subunit YP_041000.1 1676959 R 282458 CDS YP_041001.1 49483777 2859053 complement(1678314..1678778) 1 NC_002952.2 Similar to Bacillus subtilis biotin carboxyl carrier protein of acetyl-CoA carboxylase AccB SW:BCCP_BACSU (P49786) (159 aa) fasta scores: E(): 6.7e-20, 50.318% id in 157 aa, and to Synechocystis sp biotin carboxyl carrier protein of acetyl-CoA carboxylase SLR0435 TR:Q55120 (EMBL:D64001) (154 aa) fasta scores: E(): 4.5e-18, 41.935% id in 155 aa; biotin carboxyl carrier protein of acetyl-CoA carboxylase 1678778 accB 2859053 accB Staphylococcus aureus subsp. aureus MRSA252 biotin carboxyl carrier protein of acetyl-CoA carboxylase YP_041001.1 1678314 R 282458 CDS YP_041002.1 49483778 2859611 complement(1679252..1679809) 1 NC_002952.2 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 1679809 efp 2859611 efp Staphylococcus aureus subsp. aureus MRSA252 elongation factor P YP_041002.1 1679252 R 282458 CDS YP_041003.1 49483779 2860844 complement(1679835..1680896) 1 NC_002952.2 Similar to Bacillus halodurans Xaa-Pro dipeptidase BH2800 TR:Q9K950 (EMBL:AP001516) (355 aa) fasta scores: E(): 2.8e-62, 48.148% id in 351 aa, and to Bacillus subtilis peptidase YqhT SW:YQHT_BACSU (P54518) (353 aa) fasta scores: E(): 3.4e-59, 46.307% id in 352 aa; peptidase 1680896 2860844 SAR1607 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_041003.1 1679835 R 282458 CDS YP_041004.1 49483780 2860845 1681001..1681582 1 NC_002952.2 No significant database matches. Contains coiled-coiled domain, residues 38 to 59; hypothetical protein 1681582 2860845 SAR1608 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041004.1 1681001 D 282458 CDS YP_041005.1 49483781 2860846 1681596..1681814 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Bacillus halodurans hypothetical protein BH2804 TR:Q9K946 (EMBL:AP001516) (136 aa) fasta scores: E(): 9.2, 29.032% id in 62 aa, and to the C-terminal region of Anabaena sp strain pcc 7120 hypothetical protein TR:Q44229 (EMBL:U13768) (108 aa) fasta scores: E(): 2.7, 30.000% id in 50 aa; hypothetical protein 1681814 2860846 SAR1609 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041005.1 1681596 D 282458 CDS YP_041006.1 49483782 2860847 complement(1681878..1682708) 1 NC_002952.2 Similar to Bacillus halodurans lipoate protein ligase BH2812 TR:Q9K938 (EMBL:AP001516) (276 aa) fasta scores: E(): 1.9e-70, 64.364% id in 275 aa, and to Bacillus subtilis hypothetical protein YqhM TR:O32018 (EMBL:Z99116) (278 aa) fasta scores: E(): 5.4e-68, 62.182% id in 275 aa; lipoate-protein ligase A protein 1682708 2860847 SAR1610 Staphylococcus aureus subsp. aureus MRSA252 lipoate-protein ligase A protein YP_041006.1 1681878 R 282458 CDS YP_041007.1 49483783 2860848 1682866..1683252 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqhL SW:YQHL_BACSU (P54510) (126 aa) fasta scores: E(): 6.1e-21, 51.200% id in 125 aa, and to Bacillus halodurans hypothetical protein BH2813 TR:Q9K937 (EMBL:AP001516) (125 aa) fasta scores: E(): 1.7e-19, 48.387% id in 124 aa; hypothetical protein 1683252 2860848 SAR1611 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041007.1 1682866 D 282458 CDS YP_041008.1 49483784 2860849 complement(1683637..1685109) 1 NC_002952.2 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; glycine dehydrogenase subunit 2 1685109 2860849 SAR1612 Staphylococcus aureus subsp. aureus MRSA252 glycine dehydrogenase subunit 2 YP_041008.1 1683637 R 282458 CDS YP_041009.1 49483785 2860850 complement(1685102..1686457) 1 NC_002952.2 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein; glycine dehydrogenase subunit 1 1686457 2860850 SAR1613 Staphylococcus aureus subsp. aureus MRSA252 glycine dehydrogenase subunit 1 YP_041009.1 1685102 R 282458 CDS YP_041010.1 49483786 2860696 complement(1686468..1687559) 1 NC_002952.2 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 1687559 gcvT 2860696 gcvT Staphylococcus aureus subsp. aureus MRSA252 glycine cleavage system aminomethyltransferase T YP_041010.1 1686468 R 282458 CDS YP_041011.1 49483787 2860851 complement(1687718..1688242) 1 NC_002952.2 Similar to Bacillus subtilis shikimate kinase AroK SW:AROK_BACSU (P37944) (186 aa) fasta scores: E(): 2.9e-09, 32.164% id in 171 aa, and to Aquifex aeolicus shikimate kinase AQ_2177 SW:AROK_AQUAE (O67925) (168 aa) fasta scores: E(): 2.2e-12, 34.507% id in 142 aa; shikimate kinase 1688242 2860851 SAR1615 Staphylococcus aureus subsp. aureus MRSA252 shikimate kinase YP_041011.1 1687718 R 282458 CDS YP_041012.1 49483788 2860852 complement(1688475..1688972) 1 NC_002952.2 Poor database matches. Similar to Streptococcus pyogenes competence protein SPY0106 TR:Q9A1T4 (EMBL:AE006481) (144 aa) fasta scores: E(): 0.054, 27.068% id in 133 aa. Possible alternative translational start site; hypothetical protein 1688972 2860852 SAR1616 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041012.1 1688475 R 282458 CDS YP_041013.1 49483789 2860853 complement(1688890..1689189) 1 NC_002952.2 Poor database matches. Similar to Streptococcus gordonii challis hypothetical protein ComYC TR:O06668 (EMBL:U81957) (105 aa) fasta scores: E(): 7.9, 18.367% id in 98 aa; hypothetical protein 1689189 2860853 SAR1617 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041013.1 1688890 R 282458 CDS YP_041014.1 49483790 2860854 complement(1689176..1689610) 1 NC_002952.2 Similar to Bacillus subtilis comG operon protein 4 precursor ComG4 SW:CMGD_BACSU (P25956) (143 aa) fasta scores: E(): 0.92, 21.233% id in 146 aa, and to Burkholderia cepacia type II secretion pathway protein GspH TR:Q9LAN3 (EMBL:AF127982) (157 aa) fasta scores: E(): 3.6, 26.174% id in 149 aa; hypothetical protein 1689610 2860854 SAR1618 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041014.1 1689176 R 282458 CDS YP_041015.1 49483791 2860855 complement(1689600..1689911) 1 NC_002952.2 Similar to Bacillus subtilis comG operon protein 3 precursor ComG3 SW:CMGC_BACSU (P25955) (98 aa) fasta scores: E(): 1.5e-10, 41.758% id in 91 aa, and to Bacillus halodurans comG operon protein 3 homologue precursor BH2827 SW:CMGC_BACHD (Q9K923) (102 aa) fasta scores: E(): 7e-10, 35.714% id in 98 aa; hypothetical protein 1689911 2860855 SAR1619 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041015.1 1689600 R 282458 CDS YP_041016.1 49483792 2860856 complement(1689925..1690995) 1 NC_002952.2 Similar to Bacillus subtilis comG operon protein 2 ComG2 SW:CMGB_BACSU (P25954) (323 aa) fasta scores: E(): 6.2e-21, 24.138% id in 319 aa, and to Pseudomonas putida type 4 fimbrial assembly protein PilC SW:PILC_PSEPU (P36641) (401 aa) fasta scores: E(): 1.7e-11, 23.907% id in 343 aa; hypothetical protein 1690995 2860856 SAR1620 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041016.1 1689925 R 282458 CDS YP_041017.1 49483793 2860857 complement(1690967..1691941) 1 NC_002952.2 Poor database matches. N-terminus is similar to the N-terminal region of Bacillus subtilis comG operon protein 1 ComG1 SW:CMGA_BACSU (P25953) (356 aa) fasta scores: E(): 4.6e-32, 39.405% id in 269 aa; hypothetical protein 1691941 2860857 SAR1621 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041017.1 1690967 R 282458 CDS YP_041018.1 49483794 2860858 complement(1691993..1692616) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2820 TR:Q9K930 (EMBL:AP001516) (211 aa) fasta scores: E(): 3.6e-28, 49.038% id in 208 aa, and to Bacillus subtilis hypothetical protein YqgX SW:YQGX_BACSU (P54501) (211 aa) fasta scores: E(): 4.9e-26, 41.232% id in 211 aa; metallo-beta-lactamase superfamily protein 1692616 2860858 SAR1622 Staphylococcus aureus subsp. aureus MRSA252 metallo-beta-lactamase superfamily protein YP_041018.1 1691993 R 282458 CDS YP_041019.1 49483795 2860859 complement(1692613..1692942) 1 NC_002952.2 Similar to Staphylococcus xylosus hypothetical protein DglA SW:DGLA_STAXY (Q56200) (107 aa) fasta scores: E(): 1.8e-30, 80.189% id in 106 aa, and to the C-terminal region of Bacillus halodurans hypothetical protein BH1437 TR:Q9KCY2 (EMBL:AP001512) (358 aa) fasta scores: E(): 4.8e-19, 57.407% id in 108 aa; hypothetical protein 1692942 2860859 SAR1623 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041019.1 1692613 R 282458 CDS YP_041020.1 49483796 2859919 complement(1692942..1693928) 1 NC_002952.2 Similar to Staphylococcus xylosus glucokinase GlkA SW:GLK_STAXY (Q56198) (328 aa) fasta scores: E(): 1.3e-109, 83.537% id in 328 aa, and to Bacillus megaterium glucose kinase Glk TR:O31392 (EMBL:AJ000005) (324 aa) fasta scores: E(): 1.6e-46, 42.947% id in 319 aa; glucokinase 1693928 glkA 2859919 glkA Staphylococcus aureus subsp. aureus MRSA252 glucokinase YP_041020.1 1692942 R 282458 CDS YP_041021.1 49483797 2860860 complement(1693925..1694128) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqgQ SW:YQGQ_BACSU (P54494) (71 aa) fasta scores: E(): 9.1e-05, 33.333% id in 63 aa, and to Streptococcus pyogenes hypothetical protein SPY1530 TR:Q99YU8 (EMBL:AE006586) (67 aa) fasta scores: E(): 0.0011, 41.270% id in 63 aa. Doubtful CDS, poor translational start site; hypothetical protein 1694128 2860860 SAR1625 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041021.1 1693925 R 282458 CDS YP_041022.1 49483798 2860861 complement(1694109..1695572) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1421 TR:Q9KCZ8 (EMBL:AP001512) (514 aa) fasta scores: E(): 4.9e-19, 24.376% id in 521 aa, and to Bacillus subtilis hypothetical protein YqgP SW:YQGP_BACSU (P54493) (507 aa) fasta scores: E(): 5e-15, 23.450% id in 516 aa; hypothetical protein 1695572 2860861 SAR1626 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041022.1 1694109 R 282458 CDS YP_041023.1 49483799 2861092 complement(1695584..1696123) 1 NC_002952.2 Similar to Homo sapiens 5-formyltetrahydrofolate cyclo-ligase MthFS SW:FTHC_HUMAN (P49914) (202 aa) fasta scores: E(): 1.8e-08, 27.083% id in 192 aa, and to Streptococcus mutans hypothetical protein TR:O66124 (EMBL:AB001562) (178 aa) fasta scores: E(): 3.7e-20, 39.080% id in 174 aa; 5-formyltetrahydrofolate cyclo-ligase 1696123 2861092 SAR1627 Staphylococcus aureus subsp. aureus MRSA252 5-formyltetrahydrofolate cyclo-ligase YP_041023.1 1695584 R 282458 CDS YP_041024.1 49483800 2860162 complement(1696332..1696481) 1 NC_002952.2 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1696481 rpmG 2860162 rpmG Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L33 YP_041024.1 1696332 R 282458 CDS YP_041025.1 49483801 2861479 complement(1696594..1698669) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus penicillin-binding protein PbpF TR:Q9XDB3 (EMBL:AF098801) (691 aa) fasta scores: E(): 0, 99.421% id in 691 aa. Similar to Streptococcus pneumoniae penicillin-binding protein 2b Pbp2B TR:Q9R8Q9 (EMBL:AF068901) (680 aa) fasta scores: E(): 1.9e-65, 33.333% id in 672 aa; penicillin-binding protein 3 1698669 pbpF 2861479 pbpF Staphylococcus aureus subsp. aureus MRSA252 penicillin-binding protein 3 YP_041025.1 1696594 R 282458 CDS YP_041026.1 49483802 2859150 complement(1698789..1699388) 1 NC_002952.2 Similar to Staphylococcus aureus superoxide dismutase SodA TR:Q9Z5W5 (EMBL:AF121672) (199 aa) fasta scores: E(): 5.8e-82, 100.000% id in 199 aa, and to Staphylococcus xylosus superoxide dismutase Sod TR:Q9K4V3 (EMBL:AJ276960) (199 aa) fasta scores: E(): 6.6e-76, 91.457% id in 199 aa. Similar to SAR0135, 74.874% identity (74.874% ungapped) in 199 aa overlap; superoxide dismutase 1699388 sodA 2859150 sodA Staphylococcus aureus subsp. aureus MRSA252 superoxide dismutase YP_041026.1 1698789 R 282458 CDS YP_041027.1 49483803 2859633 complement(1699664..1700074) 1 NC_002952.2 Similar to Bacillus subtilis zinc-specific metalloregulatory protein Zur SW:ZUR_BACSU (P54479) (145 aa) fasta scores: E(): 1.6e-26, 51.852% id in 135 aa. Previously sequenced as Staphylococcus aureus ferric uptake regulation protein homologue Zur TR:Q9R3G5 (EMBL:AF121672) (136 aa) fasta scores: E(): 6.4e-52, 100.000% id in 136 aa; zinc-specific metalloregulatory protein 1700074 zur 2859633 zur Staphylococcus aureus subsp. aureus MRSA252 zinc-specific metalloregulatory protein YP_041027.1 1699664 R 282458 CDS YP_041028.1 49483804 2861311 complement(1700061..1700924) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus ABC transporter MreB TR:Q9LAP5 (EMBL:AF121672) (277 aa) fasta scores: E(): 2e-87, 100.000% id in 277 aa. Similar to Staphylococcus xylosus ABC transporter ZurM TR:Q9K4V5 (EMBL:AJ276960) (286 aa) fasta scores: E(): 7.2e-77, 82.807% id in 285 aa; ABC transporter permease 1700924 mreB 2861311 mreB Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_041028.1 1700061 R 282458 CDS YP_041029.1 49483805 2861310 complement(1700966..1701751) 1 NC_002952.2 Similar to Staphylococcus aureus ABC transporter MreA TR:Q9RGL9 (EMBL:AF121672) (261 aa) fasta scores: E(): 7.3e-85, 99.617% id in 261 aa, and to Staphylococcus xylosus ABC transporter ZurA TR:Q9K4V6 (EMBL:AJ276960) (257 aa) fasta scores: E(): 4.4e-67, 78.740% id in 254 aa. Possible alternative translational start sites; ABC transporter ATP-binding protein 1701751 mreA 2861310 mreA Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041029.1 1700966 R 282458 CDS YP_041030.1 49483806 2861093 complement(1701877..1702767) 1 NC_002952.2 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 1702767 2861093 SAR1634 Staphylococcus aureus subsp. aureus MRSA252 endonuclease IV YP_041030.1 1701877 R 282458 CDS YP_041031.1 49483807 2861094 complement(1702777..1704123) 1 NC_002952.2 Similar to N-terminal region of Escherichia coli cold-shock deaD-box protein A DeaD SW:DEAD_ECOLI (P23304) (628 aa) fasta scores: E(): 2.3e-38, 29.806% id in 463 aa, and to the full length Bacillus subtilis probable RNA helicase YqfR SW:YQFR_BACSU (P54475) (438 aa) fasta scores: E(): 3e-72, 47.153% id in 439 aa; helicase 1704123 2861094 SAR1635 Staphylococcus aureus subsp. aureus MRSA252 helicase YP_041031.1 1702777 R 282458 CDS YP_041032.1 49483808 2861095 complement(1704237..1705337) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1380 SW:YD80_BACHD (Q9KD39) (372 aa) fasta scores: E(): 7.9e-48, 37.903% id in 372 aa, and to Bacillus subtilis hypothetical protein YqfO SW:YQFO_BACSU (P54472) (373 aa) fasta scores: E(): 5.6e-43, 36.438% id in 365 aa; hypothetical protein 1705337 2861095 SAR1636 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041032.1 1704237 R 282458 CDS YP_041033.1 49483809 2861096 complement(1705340..1706017) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YkiC TR:Q9CGM4 (EMBL:AE006340) (230 aa) fasta scores: E(): 7e-29, 45.815% id in 227 aa, and to Streptococcus pyogenes hypothetical protein SPY0930 TR:Q9A050 (EMBL:AE006542) (228 aa) fasta scores: E(): 1.1e-26, 42.788% id in 208 aa; hypothetical protein 1706017 2861096 SAR1637 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041033.1 1705340 R 282458 CDS YP_041034.1 49483810 2860171 complement(1706148..1707254) 1 NC_002952.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 1707254 rpoD 2860171 rpoD Staphylococcus aureus subsp. aureus MRSA252 RNA polymerase sigma factor RpoD YP_041034.1 1706148 R 282458 CDS YP_041035.1 49483811 2859601 complement(1707478..1709277) 1 NC_002952.2 Similar to Bacillus subtilis DNA primase DnaG SW:PRIM_BACSU (P05096) (603 aa) fasta scores: E(): 7.4e-70, 36.529% id in 605 aa. Previously sequenced as Staphylococcus aureus DNA primase DnaG SW:PRIM_STAAU (O05338) (572 aa) fasta scores: E(): 4.3e-208, 97.898% id in 571 aa; DNA primase 1709277 dnaG 2859601 dnaG Staphylococcus aureus subsp. aureus MRSA252 DNA primase YP_041035.1 1707478 R 282458 CDS YP_041036.1 49483812 2861097 complement(1709338..1710156) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqfL SW:YQFL_BACSU (P54470) (270 aa) fasta scores: E(): 1.3e-52, 58.015% id in 262 aa, and to Bacillus halodurans hypothetical protein BH1373 TR:Q9KD46 (EMBL:AP001511) (270 aa) fasta scores: E(): 1.7e-52, 59.144% id in 257 aa; hypothetical protein 1710156 2861097 SAR1640 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041036.1 1709338 R 282458 CDS YP_041037.1 49483813 2861099 1711125..1712516 1 NC_002952.2 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 1712516 2861099 SAR1642 Staphylococcus aureus subsp. aureus MRSA252 glycyl-tRNA synthetase YP_041037.1 1711125 D 282458 CDS YP_041038.1 49483814 2861100 complement(1712667..1713419) 1 NC_002952.2 Similar to Bacillus subtilis DNA repair protein RecO SW:RECO_BACSU (P42095) (255 aa) fasta scores: E(): 3.6e-23, 28.287% id in 251 aa, and to Bacillus halodurans hypothetical protein BH1369 TR:Q9KD50 (EMBL:AP001511) (254 aa) fasta scores: E(): 3e-22, 28.629% id in 248 aa; recombination protein O 1713419 2861100 SAR1643 Staphylococcus aureus subsp. aureus MRSA252 recombination protein O YP_041038.1 1712667 R 282458 CDS YP_041039.1 49483815 2859613 complement(1713441..1714340) 1 NC_002952.2 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 1714340 era 2859613 era Staphylococcus aureus subsp. aureus MRSA252 GTP-binding protein Era YP_041039.1 1713441 R 282458 CDS YP_041040.1 49483816 2861355 complement(1714341..1714745) 1 NC_002952.2 Similar to Homo sapiens cytidine deaminase CDA SW:CDD_HUMAN (P32320) (146 aa) fasta scores: E(): 4.2e-21, 47.101% id in 138 aa, and to Bacillus subtilis cytidine deaminase Cdd SW:CDD_BACSU (P19079) (136 aa) fasta scores: E(): 7.3e-21, 50.000% id in 124 aa; cytidine deaminase 1714745 cdd 2861355 cdd Staphylococcus aureus subsp. aureus MRSA252 cytidine deaminase YP_041040.1 1714341 R 282458 CDS YP_041041.1 49483817 2861101 complement(1714756..1715100) 1 NC_002952.2 Similar to Escherichia coli diacylglycerol kinase DgkA SW:KDGL_ECOLI (P00556) (121 aa) fasta scores: E(): 4.3e-07, 34.545% id in 110 aa, and to Bacillus halodurans diacylglycerol kinase BH1364 TR:Q9KD55 (EMBL:AP001511) (130 aa) fasta scores: E(): 5.4e-14, 42.857% id in 112 aa; diacylglycerol kinase 1715100 2861101 SAR1646 Staphylococcus aureus subsp. aureus MRSA252 diacylglycerol kinase YP_041041.1 1714756 R 282458 CDS YP_041042.1 49483818 2861102 complement(1715103..1715570) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqfG SW:YQFG_BACSU (P46347) (157 aa) fasta scores: E(): 6e-29, 56.579% id in 152 aa, and to Bacillus halodurans hypothetical protein BH1363 TR:Q9KD56 (EMBL:AP001511) (159 aa) fasta scores: E(): 4.5e-25, 55.128% id in 156 aa; hypothetical protein 1715570 2861102 SAR1647 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041042.1 1715103 R 282458 CDS YP_041043.1 49483819 2861103 complement(1715571..1716518) 1 NC_002952.2 Similar to Bacillus megaterium hypothetical protein TR:Q9ZEF6 (EMBL:AJ224829) (324 aa) fasta scores: E(): 9.3e-66, 65.372% id in 309 aa, and to Bacillus subtilis PhoH-like protein PhoH SW:PHOL_BACSU (P46343) (319 aa) fasta scores: E(): 2.5e-64, 62.903% id in 310 aa; PhoH-like protein 1716518 2861103 SAR1648 Staphylococcus aureus subsp. aureus MRSA252 PhoH-like protein YP_041043.1 1715571 R 282458 CDS YP_041044.1 49483820 2861104 complement(1716821..1717519) 1 NC_002952.2 hypothetical protein 1717519 2861104 SAR1649 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041044.1 1716821 R 282458 CDS YP_041045.1 49483821 2861105 complement(1717536..1718525) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqfA SW:YQFA_BACSU (P54466) (331 aa) fasta scores: E(): 4.4e-80, 78.019% id in 323 aa, and to Bacillus halodurans hypothetical protein BH1357 TR:Q9KD62 (EMBL:AP001511) (331 aa) fasta scores: E(): 8.3e-79, 76.161% id in 323 aa; hypothetical protein 1718525 2861105 SAR1650 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041045.1 1717536 R 282458 CDS YP_041046.1 49483822 2861106 complement(1718543..1719250) 1 NC_002952.2 Similar to C-terminal regions of Bacillus subtilis hypothetical protein YqeZ SW:YQEZ_BACSU (P54465) (437 aa) fasta scores: E(): 2e-24, 35.000% id in 220 aa, and Bacillus halodurans hypothetical protein BH1356 TR:Q9KD63 (EMBL:AP001511) (445 aa) fasta scores: E(): 1.4e-18, 32.766% id in 235 aa; hypothetical protein 1719250 2861106 SAR1651 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041046.1 1718543 R 282458 CDS YP_041047.1 49483823 2861457 complement(1719470..1719646) 1 NC_002952.2 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1719646 rpsU 2861457 rpsU Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S21 YP_041047.1 1719470 R 282458 CDS YP_041048.1 49483824 2861107 complement(1719939..1721285) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqeV SW:YQEV_BACSU (P54462) (451 aa) fasta scores: E(): 3.3e-131, 77.273% id in 440 aa, and to Bacillus halodurans hypothetical protein BH1351 TR:Q9KD68 (EMBL:AP001511) (448 aa) fasta scores: E(): 3.7e-131, 77.677% id in 439 aa; hypothetical protein 1721285 2861107 SAR1653 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041048.1 1719939 R 282458 CDS YP_041049.1 49483825 2861108 complement(1721292..1722044) 1 NC_002952.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1722044 2861108 SAR1654 Staphylococcus aureus subsp. aureus MRSA252 16S ribosomal RNA methyltransferase RsmE YP_041049.1 1721292 R 282458 CDS YP_041050.1 49483826 2861109 complement(1722046..1722984) 1 NC_002952.2 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 1722984 prmA 2861109 prmA Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L11 methyltransferase YP_041050.1 1722046 R 282458 CDS YP_041051.1 49483827 2859603 complement(1722988..1724127) 1 NC_002952.2 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 1724127 dnaJ 2859603 dnaJ Staphylococcus aureus subsp. aureus MRSA252 chaperone protein DnaJ YP_041051.1 1722988 R 282458 CDS YP_041052.1 49483828 2859604 complement(1724263..1726095) 1 NC_002952.2 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 1726095 dnaK 2859604 dnaK Staphylococcus aureus subsp. aureus MRSA252 molecular chaperone DnaK YP_041052.1 1724263 R 282458 CDS YP_041053.1 49483829 2859945 complement(1726164..1726790) 1 NC_002952.2 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 1726790 grpE 2859945 grpE Staphylococcus aureus subsp. aureus MRSA252 heat shock protein GrpE YP_041053.1 1726164 R 282458 CDS YP_041054.1 49483830 2859647 complement(1726822..1727799) 1 NC_002952.2 Similar to Bacillus subtilis heat-inducible transcription repressor HrcA SW:HRCA_BACSU (P25499) (343 aa) fasta scores: E(): 5.1e-30, 31.138% id in 334 aa. Previously sequenced as Staphylococcus aureus heat-inducible transcription repressor HrcA SW:HRCA_STAAU (P45556) (325 aa) fasta scores: E(): 9.8e-112, 99.692% id in 325 aa; heat-inducible transcription repressor 1727799 hrcA 2859647 hrcA Staphylococcus aureus subsp. aureus MRSA252 heat-inducible transcription repressor YP_041054.1 1726822 R 282458 CDS YP_041055.1 49483831 2861110 complement(1727900..1729024) 1 NC_002952.2 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1729024 2861110 SAR1660 Staphylococcus aureus subsp. aureus MRSA252 coproporphyrinogen III oxidase YP_041055.1 1727900 R 282458 CDS YP_041056.1 49483832 2859697 complement(1729531..1731354) 1 NC_002952.2 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1731354 lepA 2859697 lepA Staphylococcus aureus subsp. aureus MRSA252 GTP-binding protein LepA YP_041056.1 1729531 R 282458 CDS YP_041057.1 49483833 2861456 1731700..1731951 1 NC_002952.2 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1731951 rpsT 2861456 rpsT Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S20 YP_041057.1 1731700 D 282458 CDS YP_041058.1 49483834 2861111 complement(1731996..1732970) 1 NC_002952.2 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 1732970 holA 2861111 holA Staphylococcus aureus subsp. aureus MRSA252 DNA polymerase III subunit delta YP_041058.1 1731996 R 282458 CDS YP_041059.1 49483835 2861112 complement(1733027..1735228) 1 NC_002952.2 Similar to Lactococcus lactis competence protein ComEC TR:Q9CER4 (EMBL:AE006407) (736 aa) fasta scores: E(): 3.9e-30, 26.139% id in 746 aa, and to Bacillus subtilis comE operon protein 3 ComE3 SW:CME3_BACSU (P39695) (776 aa) fasta scores: E(): 1.4e-23, 26.057% id in 733 aa; hypothetical protein 1735228 2861112 SAR1665 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041059.1 1733027 R 282458 CDS YP_041060.1 49483836 2861113 complement(1735233..1735694) 1 NC_002952.2 Similar to Streptococcus pyogenes late competence protein required for DNA binding SPY1823 TR:Q99Y86 (EMBL:AE006609) (153 aa) fasta scores: E(): 2.3e-31, 56.716% id in 134 aa, and to the C-terminal region of to Saccharomyces cerevisiae deoxycytidylate deaminase DCD1 SW:DCTD_YEAST (P06773) (312 aa) fasta scores: E(): 4.9e-16, 38.000% id in 150 aa; deaminase 1735694 2861113 SAR1666 Staphylococcus aureus subsp. aureus MRSA252 deaminase YP_041060.1 1735233 R 282458 CDS YP_041061.1 49483837 2861114 complement(1735786..1736463) 1 NC_002952.2 Similar to Listeria monocytogenes competence protein 1 TR:Q9EYL7 (EMBL:AF320589) (211 aa) fasta scores: E(): 1.6e-17, 36.744% id in 215 aa, and to Bacillus subtilis comE operon protein 1 ComE1 SW:CME1_BACSU (P39694) (205 aa) fasta scores: E(): 8.9e-18, 39.779% id in 181 aa; hypothetical protein 1736463 2861114 SAR1667 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041061.1 1735786 R 282458 CDS YP_041062.1 49483838 2861115 complement(1736512..1737228) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqeM SW:YQEM_BACSU (P54458) (247 aa) fasta scores: E(): 6.8e-31, 40.909% id in 242 aa, and to Streptococcus pyogenes hypothetical protein SPY0312 TR:Q9A1E9 (EMBL:AE006496) (263 aa) fasta scores: E(): 1.3e-29, 37.037% id in 243 aa; hypothetical protein 1737228 2861115 SAR1668 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041062.1 1736512 R 282458 CDS YP_041063.1 49483839 2861116 complement(1737231..1737584) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1328 TR:Q9KD89 (EMBL:AP001511) (117 aa) fasta scores: E(): 2.4e-26, 64.815% id in 108 aa, and to Bacillus subtilis hypothetical protein YqeL SW:YQEL_BACSU (P54457) (118 aa) fasta scores: E(): 5.7e-25, 60.550% id in 109 aa; hypothetical protein 1737584 2861116 SAR1669 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041063.1 1737231 R 282458 CDS YP_041064.1 49483840 2861117 complement(1737585..1738169) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1327 TR:Q9KD90 (EMBL:AP001511) (187 aa) fasta scores: E(): 1.5e-24, 43.407% id in 182 aa, and to Bacillus subtilis hypothetical protein YqeK SW:YQEK_BACSU (P54456) (186 aa) fasta scores: E(): 2.4e-23, 39.891% id in 183 aa; hypothetical protein 1738169 2861117 SAR1670 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041064.1 1737585 R 282458 CDS YP_041065.1 49483841 2861118 complement(1738159..1738728) 1 NC_002952.2 Similar to Bacillus subtilis probable nicotinate-nucleotide adenylyltransferase NadD SW:NADD_BACSU (P54455) (189 aa) fasta scores: E(): 2.2e-22, 33.511% id in 188 aa, and to Bacillus halodurans probable nicotinate-nucleotide adenylyltransferase BH1326 SW:NADD_BACHD (Q9KD91) (207 aa) fasta scores: E(): 2.9e-21, 37.500% id in 192 aa; hypothetical protein 1738728 2861118 SAR1671 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041065.1 1738159 R 282458 CDS YP_041066.1 49483842 2861119 complement(1738731..1739021) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqeI SW:YQEI_BACSU (P54454) (96 aa) fasta scores: E(): 3.8e-21, 66.667% id in 96 aa, and to Bacillus halodurans hypothetical protein BH1325 TR:Q9KD92 (EMBL:AP001511) (96 aa) fasta scores: E(): 5.2e-21, 65.625% id in 96 aa; hypothetical protein 1739021 2861119 SAR1672 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041066.1 1738731 R 282458 CDS YP_041067.1 49483843 2859863 complement(1739025..1739831) 1 NC_002952.2 Similar to Escherichia coli shikimate 5-dehydrogenase AroE SW:AROE_ECOLI (P15770) (272 aa) fasta scores: E(): 5.7e-21, 34.409% id in 279 aa, and to Bacillus subtilis shikimate 5-dehydrogenase AroD SW:AROE_BACSU (P54374) (280 aa) fasta scores: E(): 1.5e-31, 37.956% id in 274 aa; shikimate 5-dehydrogenase 1739831 aroE 2859863 aroE Staphylococcus aureus subsp. aureus MRSA252 shikimate 5-dehydrogenase YP_041067.1 1739025 R 282458 CDS YP_041068.1 49483844 2861120 complement(1739845..1740945) 1 NC_002952.2 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 1740945 2861120 SAR1674 Staphylococcus aureus subsp. aureus MRSA252 GTP-binding protein YqeH YP_041068.1 1739845 R 282458 CDS YP_041069.1 49483845 2861121 complement(1740946..1741473) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YqeG SW:YQEG_BACSU (P54452) (172 aa) fasta scores: E(): 4.1e-37, 58.140% id in 172 aa, and to Bacillus halodurans hypothetical protein BH1322 TR:Q9KD95 (EMBL:AP001511) (171 aa) fasta scores: E(): 3.4e-31, 52.663% id in 169 aa; hypothetical protein 1741473 2861121 SAR1675 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041069.1 1740946 R 282458 CDS YP_041070.1 49483846 2859898 complement(1741493..1742179) 1 NC_002952.2 Similar to Escherichia coli 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) nucleosidase Pfs SW:MTN_ECOLI (P24247) (232 aa) fasta scores: E(): 1.2e-40, 54.185% id in 227 aa, and to Vibrio cholerae MTA/SAH nucleosidase VC2379 TR:Q9KPI8 (EMBL:AE004308) (231 aa) fasta scores: E(): 1.8e-40, 53.509% id in 228 aa; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1742179 pfs 2859898 pfs Staphylococcus aureus subsp. aureus MRSA252 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_041070.1 1741493 R 282458 CDS YP_041071.1 49483847 2861122 1742493..1742762 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 1742762 2861122 SAR1677 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041071.1 1742493 D 282458 CDS YP_041072.1 49483848 2861124 complement(1743730..1743909) 1 NC_002952.2 Doubtful CDS. No significant database matches; hypothetical protein 1743909 2861124 SAR1680 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041072.1 1743730 R 282458 CDS YP_041073.1 49483849 2861126 complement(1745773..1747005) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1820 TR:Q9KBV4 (EMBL:AP001513) (385 aa) fasta scores: E(): 2.1e-74, 55.670% id in 388 aa, and to Bacillus subtilis hypothetical protein YcsG SW:YCSG_BACSU (P42964) (386 aa) fasta scores: E(): 5e-71, 54.617% id in 379 aa; hypothetical protein 1747005 2861126 SAR1683 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041073.1 1745773 R 282458 CDS YP_041074.1 49483850 2861127 complement(1747017..1747769) 1 NC_002952.2 Similar to Bacillus halodurans lactam utilization protein BH1821 TR:Q9KBV3 (EMBL:AP001513) (257 aa) fasta scores: E(): 7.3e-54, 54.472% id in 246 aa, and to Campylobacter jejuni hypothetical protein CJ1541 TR:Q9PMC8 (EMBL:AL139078) (255 aa) fasta scores: E(): 2.4e-49, 55.422% id in 249 aa; LamB/YcsF family protein 1747769 2861127 SAR1684 Staphylococcus aureus subsp. aureus MRSA252 LamB/YcsF family protein YP_041074.1 1747017 R 282458 CDS YP_041075.1 49483851 2861128 complement(1747769..1749130) 1 NC_002952.2 Similar to Anabaena sp biotin carboxylase AccC SW:ACCC_ANASP (Q06862) (447 aa) fasta scores: E(): 2.6e-78, 48.081% id in 443 aa, and to Lactococcus lactis biotin carboxylase AccC TR:Q9CHF3 (EMBL:AE006311) (455 aa) fasta scores: E(): 3.7e-82, 51.242% id in 443 aa; biotin carboxylase 1749130 2861128 SAR1685 Staphylococcus aureus subsp. aureus MRSA252 biotin carboxylase YP_041075.1 1747769 R 282458 CDS YP_041076.1 49483852 2861129 complement(1749144..1749593) 1 NC_002952.2 Similar to Bacillus subtilis biotin carboxyl carrier protein of acetyl-CoA carboxylase AccB SW:BCCP_BACSU (P49786) (159 aa) fasta scores: E(): 7.2e-08, 30.573% id in 157 aa, and to Aquifex aeolicus biotin carboxyl carrier protein AQ_1363 TR:O67375 (EMBL:AE000736) (154 aa) fasta scores: E(): 1e-07, 31.333% id in 150 aa; biotin carboxyl carrier protein of acetyl-CoA carboxylase 1749593 2861129 SAR1686 Staphylococcus aureus subsp. aureus MRSA252 biotin carboxyl carrier protein of acetyl-CoA carboxylase YP_041076.1 1749144 R 282458 CDS YP_041077.1 49483853 2861130 complement(1749595..1750605) 1 NC_002952.2 Similar to Pyrococcus horikoshii hypothetical protein PH0988 TR:O58716 (EMBL:AP000004) (331 aa) fasta scores: E(): 3.2e-34, 38.014% id in 292 aa, and to Pyrococcus abyssi hypothetical protein PAB1714 TR:Q9V007 (EMBL:AJ248286) (331 aa) fasta scores: E(): 5.7e-34, 37.500% id in 304 aa; hypothetical protein 1750605 2861130 SAR1687 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041077.1 1749595 R 282458 CDS YP_041078.1 49483854 2859379 complement(1750595..1751329) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1817 TR:Q9KBV7 (EMBL:AP001513) (225 aa) fasta scores: E(): 1.5e-34, 43.243% id in 222 aa, and to Campylobacter jejuni hypothetical protein CJ1542 TR:Q9PMC7 (EMBL:AL139078) (246 aa) fasta scores: E(): 1.5e-31, 42.672% id in 232 aa; hypothetical protein 1751329 2859379 SAR1688 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041078.1 1750595 R 282458 CDS YP_041079.1 49483855 2859940 complement(1751655..1752131) 1 NC_002952.2 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1752131 greA 2859940 greA Staphylococcus aureus subsp. aureus MRSA252 transcription elongation factor GreA YP_041079.1 1751655 R 282458 CDS YP_041080.1 49483856 2860410 complement(1752159..1752782) 1 NC_002952.2 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1752782 udk 2860410 udk Staphylococcus aureus subsp. aureus MRSA252 uridine kinase YP_041080.1 1752159 R 282458 CDS YP_041081.1 49483857 2859380 complement(1752782..1754050) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YrrO TR:O32034 (EMBL:Z99117) (422 aa) fasta scores: E(): 2.5e-125, 75.481% id in 416 aa, and to Bacillus halodurans protease BH1274 TR:Q9KDD9 (EMBL:AP001511) (420 aa) fasta scores: E(): 9.9e-121, 72.195% id in 410 aa; peptidase 1754050 2859380 SAR1691 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_041081.1 1752782 R 282458 CDS YP_041082.1 49483858 2859381 complement(1754062..1754985) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YrrN TR:O32035 (EMBL:Z99117) (309 aa) fasta scores: E(): 3.9e-66, 54.754% id in 305 aa, and to Bacillus halodurans protease BH1273 TR:Q9KDE0 (EMBL:AP001511) (309 aa) fasta scores: E(): 9.6e-65, 53.770% id in 305 aa; peptidase 1754985 2859381 SAR1692 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_041082.1 1754062 R 282458 CDS YP_041083.1 49483859 2859382 complement(1754988..1755626) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YrrM TR:O32036 (EMBL:Z99117) (217 aa) fasta scores: E(): 7.1e-23, 37.561% id in 205 aa, and to Bacillus halodurans O-methyltransferase BH1272 TR:Q9KDE1 (EMBL:AP001511) (223 aa) fasta scores: E(): 2e-22, 35.577% id in 208 aa; O-methyltransferase 1755626 2859382 SAR1693 Staphylococcus aureus subsp. aureus MRSA252 O-methyltransferase YP_041083.1 1754988 R 282458 CDS YP_041084.1 49483860 2859383 complement(1755911..1756219) 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY2112 TR:Q99XP5 (EMBL:AE006631) (101 aa) fasta scores: E(): 1.8e-08, 40.196% id in 102 aa, and to Lactococcus lactis hypothetical protein YbeC TR:Q9CJ62 (EMBL:AE006252) (107 aa) fasta scores: E(): 5.5e-08, 38.235% id in 102 aa; hypothetical protein 1756219 2859383 SAR1694 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041084.1 1755911 R 282458 CDS YP_041085.1 49483861 2859384 complement(1756234..1756662) 1 NC_002952.2 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 1756662 2859384 SAR1695 Staphylococcus aureus subsp. aureus MRSA252 Holliday junction resolvase-like protein YP_041085.1 1756234 R 282458 CDS YP_041086.1 49483862 2859385 complement(1756666..1756926) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1268 TR:Q9KDE5 (EMBL:AP001511) (90 aa) fasta scores: E(): 2.6e-15, 56.322% id in 87 aa, and to Streptococcus pyogenes hypothetical protein SPY2114 TR:Q99XP3 (EMBL:AE006631) (89 aa) fasta scores: E(): 1.2e-14, 56.410% id in 78 aa; hypothetical protein 1756926 2859385 SAR1696 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041086.1 1756666 R 282458 CDS YP_041087.1 49483863 2860987 complement(1756989..1759619) 1 NC_002952.2 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1759619 alaS 2860987 alaS Staphylococcus aureus subsp. aureus MRSA252 alanyl-tRNA synthetase YP_041087.1 1756989 R 282458 CDS YP_041088.1 49483864 2859386 complement(1759962..1762439) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YrrC TR:O34481 (EMBL:Z99117) (798 aa) fasta scores: E(): 1.9e-137, 52.646% id in 756 aa, and to Streptococcus pyogenes exodeoxyribonuclease V SPY1844 TR:Q99Y68 (EMBL:AE006610) (817 aa) fasta scores: E(): 2.2e-105, 39.753% id in 810 aa; hypothetical protein 1762439 2859386 SAR1698 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041088.1 1759962 R 282458 CDS YP_041089.1 49483865 2859387 complement(1762441..1763109) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YrrB TR:O34452 (EMBL:Z99117) (206 aa) fasta scores: E(): 9.8e-21, 36.946% id in 203 aa, and to Bacillus halodurans hypothetical protein BH1262 TR:Q9KDF1 (EMBL:AP001511) (214 aa) fasta scores: E(): 4.9e-20, 34.848% id in 198 aa; hypothetical protein 1763109 2859387 SAR1699 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041089.1 1762441 R 282458 CDS YP_041090.1 49483866 2859388 complement(1763791..1764909) 1 NC_002952.2 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1764909 mnmA 2859388 mnmA Staphylococcus aureus subsp. aureus MRSA252 tRNA-specific 2-thiouridylase MnmA YP_041090.1 1763791 R 282458 CDS YP_041091.1 49483867 2859389 complement(1764910..1766052) 1 NC_002952.2 Similar to Escherichia coli Fe-S cluster formation protein, cysteine desulfurase IscS SW:ISCS_ECOLI (P39171) (404 aa) fasta scores: E(): 3.1e-50, 42.746% id in 386 aa, and to Bacillus halodurans Fe-S cluster formation protein BH1260 TR:Q9KDF3 (EMBL:AP001511) (386 aa) fasta scores: E(): 2.1e-62, 46.719% id in 381 aa; cysteine desulfurase 1766052 2859389 SAR1702 Staphylococcus aureus subsp. aureus MRSA252 cysteine desulfurase YP_041091.1 1764910 R 282458 CDS YP_041092.1 49483868 2859390 1766362..1767375 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YddN SW:YDDN_BACSU (P96651) (339 aa) fasta scores: E(): 7.4e-57, 45.593% id in 329 aa, and to Caulobacter crescentus hypothetical protein CC1957 cc1957 TR:Q9A6W9 (EMBL:AE005869) (337 aa) fasta scores: E(): 1.5e-50, 45.886% id in 316 aa; oxygenase 1767375 2859390 SAR1703 Staphylococcus aureus subsp. aureus MRSA252 oxygenase YP_041092.1 1766362 D 282458 CDS YP_041093.1 49483869 2859391 complement(1767612..1767758) 1 NC_002952.2 hypothetical protein 1767758 2859391 SAR1704 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041093.1 1767612 R 282458 CDS YP_041094.1 49483870 2859392 complement(1767798..1767980) 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY1261 TR:Q99ZE6 (EMBL:AE006565) (66 aa) fasta scores: E(): 0.0004, 46.296% id in 54 aa, and to Lactococcus lactis hypothetical protein YhjA TR:Q9CHE9 (EMBL:AE006312) (79 aa) fasta scores: E(): 0.0032, 47.059% id in 51 aa. Similar to SAR0874, 79.661% identity (79.661% ungapped) in 59 aa overlap; hypothetical protein 1767980 2859392 SAR1705 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041094.1 1767798 R 282458 CDS YP_041095.1 49483871 2859393 complement(1768080..1768502) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1259 TR:Q9KDF4 (EMBL:AP001511) (139 aa) fasta scores: E(): 3.3e-31, 65.714% id in 140 aa. N-terminus is similar to the N-terminal region of Bacillus subtilis hypothetical protein YrzC SW:YRZC_BACSU (O34527) (111 aa) fasta scores: E(): 2.8e-19, 68.132% id in 91 aa; hypothetical protein 1768502 2859393 SAR1706 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041095.1 1768080 R 282458 CDS YP_041096.1 49483872 2859394 1768587..1769861 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YrvN TR:O34528 (EMBL:Z99117) (421 aa) fasta scores: E(): 1.3e-98, 69.286% id in 420 aa, and to Bacillus halodurans hypothetical protein BH1257 TR:Q9KDF6 (EMBL:AP001511) (428 aa) fasta scores: E(): 3e-95, 66.507% id in 418 aa; recombination factor protein RarA 1769861 2859394 SAR1707 Staphylococcus aureus subsp. aureus MRSA252 recombination factor protein RarA YP_041096.1 1768587 D 282458 CDS YP_041097.1 49483873 2859395 complement(1770022..1770795) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1255 TR:Q9KDF8 (EMBL:AP001511) (259 aa) fasta scores: E(): 1.8e-57, 64.173% id in 254 aa. C-terminal region is similar to Bacillus subtilis hypothetical protein YrvM TR:O32037 (EMBL:Z99118) (161 aa) fasta scores: E(): 1.4e-38, 70.440% id in 159 aa; hypothetical protein 1770795 2859395 SAR1708 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041097.1 1770022 R 282458 CDS YP_041098.1 49483874 2859396 complement(1771009..1771110) 1 NC_002952.2 Doubtful CDS. No database matches; hypothetical protein 1771110 2859396 SAR1709 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041098.1 1771009 R 282458 CDS YP_041099.1 49483875 2859872 complement(1771256..1773022) 1 NC_002952.2 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1773022 aspS 2859872 aspS Staphylococcus aureus subsp. aureus MRSA252 aspartyl-tRNA synthetase YP_041099.1 1771256 R 282458 CDS YP_041100.1 49483876 2860715 complement(1773038..1774300) 1 NC_002952.2 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1774300 hisS 2860715 hisS Staphylococcus aureus subsp. aureus MRSA252 histidyl-tRNA synthetase YP_041100.1 1773038 R 282458 CDS YP_041101.1 49483877 2859398 complement(1775632..1776084) 1 NC_002952.2 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1776084 2859398 SAR1713 Staphylococcus aureus subsp. aureus MRSA252 D-tyrosyl-tRNA(Tyr) deacylase YP_041101.1 1775632 R 282458 CDS YP_041102.1 49483878 2859305 complement(1776096..1778306) 1 NC_002952.2 Similar to Bacillus subtilis GTP pyrophosphokinase RelA SW:RELA_BACSU (O54408) (734 aa) fasta scores: E(): 4.2e-176, 61.111% id in 738 aa. Previously sequenced as Staphylococcus aureus GTP pyrophosphokinase RelA SW:RELA_STAAU (O32419) (736 aa) fasta scores: E(): 0, 99.864% id in 736 aa. CDS is extended at the N-terminus in comparison to the B. subtilis protein and other orthologoues. Probable alternative translational start site; GTP pyrophosphokinase 1778306 relA 2859305 relA Staphylococcus aureus subsp. aureus MRSA252 GTP pyrophosphokinase YP_041102.1 1776096 R 282458 CDS YP_041103.1 49483879 2860994 complement(1778713..1779231) 1 NC_002952.2 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1779231 apt 2860994 apt Staphylococcus aureus subsp. aureus MRSA252 adenine phosphoribosyltransferase YP_041103.1 1778713 R 282458 CDS YP_041104.1 49483880 2859399 complement(1779253..1781526) 1 NC_002952.2 N-terminal region is similar to Escherichia coli single-stranded-DNA-specific exonuclease RecJ SW:RECJ_ECOLI (P21893) (577 aa) fasta scores: E(): 1.4e-18, 31.930% id in 570 aa. Full length CDS is similar to Bacillus halodurans single-strand DNA-specific exonuclease bh1240 TR:Q9KDH3 (EMBL:AP001511) (784 aa) fasta scores: E(): 1.8e-86, 38.831% id in 770 aa; single-stranded-DNA-specific exonuclease 1781526 2859399 SAR1716 Staphylococcus aureus subsp. aureus MRSA252 single-stranded-DNA-specific exonuclease YP_041104.1 1779253 R 282458 CDS YP_041105.1 49483881 2859135 complement(1781729..1784008) 1 NC_002952.2 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; bifunctional preprotein translocase subunit SecD/SecF 1784008 secF 2859135 secF Staphylococcus aureus subsp. aureus MRSA252 bifunctional preprotein translocase subunit SecD/SecF YP_041105.1 1781729 R 282458 CDS YP_041106.1 49483882 2859400 complement(1784283..1784543) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1229 SW:YC29_BACHD (Q9KDI4) (88 aa) fasta scores: E(): 5.4e-13, 53.165% id in 79 aa, and to Bacillus subtilis hypothetical protein YrbF SW:YRBF_BACSU (O32052) (89 aa) fasta scores: E(): 1e-10, 47.436% id in 78 aa; hypothetical protein 1784543 2859400 SAR1718 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041106.1 1784283 R 282458 CDS YP_041107.1 49483883 2859524 complement(1784562..1785701) 1 NC_002952.2 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 1785701 tgt 2859524 tgt Staphylococcus aureus subsp. aureus MRSA252 queuine tRNA-ribosyltransferase YP_041107.1 1784562 R 282458 CDS YP_041108.1 49483884 2859296 complement(1785724..1786749) 1 NC_002952.2 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 1786749 queA 2859296 queA Staphylococcus aureus subsp. aureus MRSA252 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_041108.1 1785724 R 282458 CDS YP_041109.1 49483885 2861462 complement(1786751..1787755) 1 NC_002952.2 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1787755 ruvB 2861462 ruvB Staphylococcus aureus subsp. aureus MRSA252 Holliday junction DNA helicase RuvB YP_041109.1 1786751 R 282458 CDS YP_041110.1 49483886 2861461 complement(1787787..1788389) 1 NC_002952.2 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1788389 ruvA 2861461 ruvA Staphylococcus aureus subsp. aureus MRSA252 Holliday junction DNA helicase RuvA YP_041110.1 1787787 R 282458 CDS YP_041111.1 49483887 2859401 complement(1788403..1788861) 1 NC_002952.2 Similar to Bacillus subtilis possible chorismate mutase PheB SW:PHEB_BACSU (P21204) (147 aa) fasta scores: E(): 4e-17, 41.007% id in 139 aa, and to Bacillus halodurans chorismate mutase BH1214 TR:Q9KDJ9 (EMBL:AP001511) (147 aa) fasta scores: E(): 2.2e-14, 39.007% id in 141 aa; hypothetical protein 1788861 2859401 SAR1723 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041111.1 1788403 R 282458 CDS YP_041112.1 49483888 2859173 complement(1788871..1790163) 1 NC_002952.2 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1790163 obgE 2859173 obgE Staphylococcus aureus subsp. aureus MRSA252 GTPase ObgE YP_041112.1 1788871 R 282458 CDS YP_041113.1 49483889 2860921 complement(1790650..1790934) 1 NC_002952.2 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1790934 rpmA 2860921 rpmA Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L27 YP_041113.1 1790650 R 282458 CDS YP_041114.1 49483890 2859402 complement(1790946..1791266) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YsxB SW:YSXB_BACSU (P26942) (112 aa) fasta scores: E(): 3.4e-11, 38.318% id in 107 aa, and to Bacillus halodurans hypothetical protein BH3010 TR:Q9K8J6 (EMBL:AP001517) (113 aa) fasta scores: E(): 1.6e-10, 40.000% id in 110 aa; hypothetical protein 1791266 2859402 SAR1726 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041114.1 1790946 R 282458 CDS YP_041115.1 49483891 2860916 complement(1791272..1791580) 1 NC_002952.2 Similar to Escherichia coli 50S ribosomal protein L21 RplU SW:RL21_ECOLI (P02422) (103 aa) fasta scores: E(): 6.6e-14, 41.748% id in 103 aa. Previously sequenced as Staphylococcus aureus 50S ribosomal protein L21 TR:AAK52740 (EMBL:AF349567) (102 aa) fasta scores: E(): 2e-35, 99.020% id in 102 aa; 50S ribosomal protein L21 1791580 rplU 2860916 rplU Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L21 YP_041115.1 1791272 R 282458 CDS YP_041116.1 49483892 2859403 complement(1791873..1792403) 1 NC_002952.2 Similar to Lactococcus lactis cell shape determining protein MreD TR:Q9CDJ0 (EMBL:AE006452) (175 aa) fasta scores: E(): 1.5e-06, 31.977% id in 172 aa, and to Bacillus subtilis rod shape-determining protein MreD SW:MRED_BACSU (Q01467) (172 aa) fasta scores: E(): 2.2e-05, 25.989% id in 177 aa; hypothetical protein 1792403 2859403 SAR1728 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041116.1 1791873 R 282458 CDS YP_041117.1 49483893 2859404 complement(1792403..1793245) 1 NC_002952.2 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 1793245 2859404 SAR1729 Staphylococcus aureus subsp. aureus MRSA252 rod shape-determining protein MreC YP_041117.1 1792403 R 282458 CDS YP_041118.1 49483894 2859405 complement(1793445..1793564) 1 NC_002952.2 Doubtful CDS. No database matches; hypothetical protein 1793564 2859405 SAR1729a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041118.1 1793445 R 282458 CDS YP_041119.1 49483895 2859406 complement(1793638..1794111) 1 NC_002952.2 hypothetical protein 1794111 2859406 SAR1730 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041119.1 1793638 R 282458 CDS YP_041120.1 49483896 2859407 1794253..1794468 1 NC_002952.2 Doubtful CDS. No significant database matches; hypothetical protein 1794468 2859407 SAR1731 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041120.1 1794253 D 282458 CDS YP_041121.1 49483897 2859408 complement(1794584..1794868) 1 NC_002952.2 hypothetical protein 1794868 2859408 SAR1732 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041121.1 1794584 R 282458 CDS YP_041122.1 49483898 2859409 complement(1795317..1795979) 1 NC_002952.2 Highly similar to Staphylococcus aureus transposon Tn554 hypothetical protein TR:Q48363 (EMBL:X03216) (220 aa) fasta scores: E(): 2.8e-82, 99.545% id in 220 aa; hypothetical protein 1795979 2859409 SAR1734 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041122.1 1795317 R 282458 CDS YP_041123.1 49483899 2859615 1796513..1797244 1 NC_002952.2 Identical to Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance protein, rRNA adenine N-6-methyltransferase ErmA SW:ERM1_STAAU (P06699) (243 aa) fasta scores: E(): 1.7e-90, 100.000% id in 243 aa. Similar to Lactobacillus reuteri rRNA adenine N-6-methyltransferase ErmGT SW:ERMG_LACRE (Q00014) (244 aa) fasta scores: E(): 2.6e-54, 61.728% id in 243 aa; rRNA adenine N-6-methyltransferase 2 1797244 ermA2 2859615 ermA2 Staphylococcus aureus subsp. aureus MRSA252 rRNA adenine N-6-methyltransferase 2 YP_041123.1 1796513 D 282458 CDS YP_041124.1 49483900 2859154 complement(1797370..1798152) 1 NC_002952.2 Identical to Staphylococcus aureus streptomycin 3''-adenylyltransferase Spc SW:S3AD_STAAU (P04827) (260 aa) fasta scores: E(): 3.5e-100, 100.000% id in 260 aa. Similar to Streptomyces coelicolor nucleotidyltransferase SCD19.10 TR:Q9F2Z2 (EMBL:AL392149) (257 aa) fasta scores: E(): 4.4e-34, 44.493% id in 227 aa; streptomycin 3''-adenylyltransferase 2 1798152 spc2 2859154 spc2 Staphylococcus aureus subsp. aureus MRSA252 streptomycin 3''-adenylyltransferase 2 YP_041124.1 1797370 R 282458 CDS YP_041125.1 49483901 2859542 complement(1798303..1798680) 1 NC_002952.2 Identical to Staphylococcus aureus transposase C from transposon Tn554 TnpC SW:TRAC_STAAU (P06698) (125 aa) fasta scores: E(): 1.1e-36, 100.000% id in 125 aa. Similar to Staphylococcus aureus transposase C from transposon psiTn554 TnpC SW:TNPF_STAAU (P37376) (125 aa) fasta scores: E(): 8e-34, 93.600% id in 125 aa; transposase C 2 1798680 tnpC2 2859542 tnpC2 Staphylococcus aureus subsp. aureus MRSA252 transposase C 2 YP_041125.1 1798303 R 282458 CDS YP_041126.1 49483902 2859540 complement(1798687..1800579) 1 NC_002952.2 Identical to Staphylococcus aureus transposase B from transposon Tn554 TnpB SW:TNPB_STAAU (P06697) (630 aa) fasta scores: E(): 0, 100.000% id in 630 aa. Similar to Staphylococcus aureus transposase B from transposon psiTn554 TnpB SW:TNPE_STAAU (P37375) (630 aa) fasta scores: E(): 0, 96.032% id in 630 aa; transposase B 2 1800579 tnpB2 2859540 tnpB2 Staphylococcus aureus subsp. aureus MRSA252 transposase B 2 YP_041126.1 1798687 R 282458 CDS YP_041127.1 49483903 2859538 complement(1800576..1801661) 1 NC_002952.2 Highly similar to Staphylococcus aureus transposase A from transposon Tn554 TnpA SW:TNPA_STAAU (P06696) (361 aa) fasta scores: E(): 6.1e-137, 99.723% id in 361 aa; transposase A 2 1801661 tnpA2 2859538 tnpA2 Staphylococcus aureus subsp. aureus MRSA252 transposase A 2 YP_041127.1 1800576 R 282458 CDS YP_041128.1 49483904 2859410 complement(1802331..1803038) 1 NC_002952.2 Similar to Vibrio cholerae leader peptidase TcpJ TR:AAK20796 (EMBL:AF325734) (253 aa) fasta scores: E(): 4.1e-07, 27.311% id in 238 aa, and to Thermotoga maritima type IV prepilin peptidase TM1696 TR:Q9X222 (EMBL:AE001810) (240 aa) fasta scores: E(): 3.2e-08, 27.727% id in 220 aa; type III leader peptidase 1803038 2859410 SAR1741 Staphylococcus aureus subsp. aureus MRSA252 type III leader peptidase YP_041128.1 1802331 R 282458 CDS YP_041129.1 49483905 2860676 complement(1803299..1804570) 1 NC_002952.2 Similar to Lactobacillus casei folylpolyglutamate synthase Fgs SW:FOLC_LACCA (P15925) (428 aa) fasta scores: E(): 4.5e-36, 32.634% id in 429 aa, and to Bacillus subtilis folylpolyglutamate synthase FolC SW:FOLC_BACSU (Q05865) (430 aa) fasta scores: E(): 3.3e-59, 43.091% id in 427 aa; folylpolyglutamate synthase 1804570 folC 2860676 folC Staphylococcus aureus subsp. aureus MRSA252 folylpolyglutamate synthase YP_041129.1 1803299 R 282458 CDS YP_041130.1 49483906 2860426 complement(1804583..1807213) 1 NC_002952.2 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1807213 valS 2860426 valS Staphylococcus aureus subsp. aureus MRSA252 valyl-tRNA synthetase YP_041130.1 1804583 R 282458 CDS YP_041131.1 49483907 2859513 1807616..1808176 1 NC_002952.2 Similar to Escherichia coli DNA-3-methyladenine glycosylase I Tag SW:3MG1_ECOLI (P05100) (187 aa) fasta scores: E(): 9.8e-30, 43.169% id in 183 aa, and to Haemophilus influenzae DNA-3-methyladenine glycosylase Tag SW:3MGA_HAEIN (P44321) (185 aa) fasta scores: E(): 1.6e-31, 46.369% id in 179 aa; DNA-3-methyladenine glycosylase I 1808176 tag 2859513 tag Staphylococcus aureus subsp. aureus MRSA252 DNA-3-methyladenine glycosylase I YP_041131.1 1807616 D 282458 CDS YP_041132.1 49483908 2859411 complement(1808399..1809472) 1 NC_002952.2 Similar to Escherichia coli, regulator of aidB, transport protein AbrB SW:ABRB_ECOLI (P75747) (348 aa) fasta scores: E(): 3.2e-15, 24.571% id in 350 aa, and to Bacillus subtilis hypothetical protein YhjN TR:O07568 (EMBL:Y14081) (384 aa) fasta scores: E(): 3.5e-08, 22.977% id in 309 aa; hypothetical protein 1809472 2859411 SAR1745 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041132.1 1808399 R 282458 CDS YP_041134.1 49483910 2860706 complement(1809667..1810953) 1 NC_002952.2 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 1810953 hemL 2860706 hemL Staphylococcus aureus subsp. aureus MRSA252 glutamate-1-semialdehyde aminotransferase YP_041134.1 1809667 R 282458 CDS YP_041135.1 49483911 2860701 complement(1811001..1811975) 1 NC_002952.2 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 1811975 hemB 2860701 hemB Staphylococcus aureus subsp. aureus MRSA252 delta-aminolevulinic acid dehydratase YP_041135.1 1811001 R 282458 CDS YP_041136.1 49483912 2860703 complement(1811978..1812646) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus uroporphyrinogen III synthase HemD TR:O34091 (EMBL:U89396) (222 aa) fasta scores: E(): 2.7e-79, 98.649% id in 222 aa. Similar to Bacillus halodurans uroporphyrinogen III cosynthase BH3045 TR:Q9K8G1 (EMBL:AP001517) (253 aa) fasta scores: E(): 2.6e-08, 27.731% id in 238 aa; uroporphyrinogen III synthase 1812646 hemD 2860703 hemD Staphylococcus aureus subsp. aureus MRSA252 uroporphyrinogen III synthase YP_041136.1 1811978 R 282458 CDS YP_041137.1 49483913 2860702 complement(1812668..1813594) 1 NC_002952.2 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 1813594 hemC 2860702 hemC Staphylococcus aureus subsp. aureus MRSA252 porphobilinogen deaminase YP_041137.1 1812668 R 282458 CDS YP_041138.1 49483914 2859413 complement(1813636..1814451) 1 NC_002952.2 Similar to Bacillus subtilis protein membrane-bound protein HemX SW:HEMX_BACSU (P16645) (276 aa) fasta scores: E(): 4.3e-27, 33.585% id in 265 aa, and to Bacillus stearothermophilus hypothetical protein HemX TR:O69100 (EMBL:AF064058) (273 aa) fasta scores: E(): 5.2e-26, 33.588% id in 262 aa; hypothetical protein 1814451 2859413 SAR1751 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041138.1 1813636 R 282458 CDS YP_041139.1 49483915 2860700 complement(1814473..1815819) 1 NC_002952.2 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1815819 hemA 2860700 hemA Staphylococcus aureus subsp. aureus MRSA252 glutamyl-tRNA reductase YP_041139.1 1814473 R 282458 CDS YP_041140.1 49483916 2859414 complement(1816036..1816626) 1 NC_002952.2 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1816626 engB 2859414 engB Staphylococcus aureus subsp. aureus MRSA252 ribosome biogenesis GTP-binding protein YsxC YP_041140.1 1816036 R 282458 CDS YP_041141.1 49483917 2859237 complement(1816780..1818042) 1 NC_002952.2 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1818042 clpX 2859237 clpX Staphylococcus aureus subsp. aureus MRSA252 ATP-dependent protease ATP-binding subunit ClpX YP_041141.1 1816780 R 282458 CDS YP_041142.1 49483918 2859534 complement(1818193..1819494) 1 NC_002952.2 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1819494 tig 2859534 tig Staphylococcus aureus subsp. aureus MRSA252 trigger factor YP_041142.1 1818193 R 282458 CDS YP_041143.1 49483919 2859415 complement(1819657..1820586) 1 NC_002952.2 hypothetical protein 1820586 2859415 SAR1756 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041143.1 1819657 R 282458 CDS YP_041144.1 49483920 2859416 complement(1820605..1821213) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YmaB SW:YMAB_BACSU (P50619) (206 aa) fasta scores: E(): 1.8e-28, 42.23% id in 206 aa, and to Thermotoga maritima conserved hypothetical protein TM1382 TR:Q9X1A2 (EMBL:AE001791) (199 aa) fasta scores: E(): 5.5e-10, 30.05% id in 193 aa; hypothetical protein 1821213 2859416 SAR1757 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041144.1 1820605 R 282458 CDS YP_041145.1 49483921 2860915 complement(1821355..1821711) 1 NC_002952.2 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1821711 rplT 2860915 rplT Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L20 YP_041145.1 1821355 R 282458 CDS YP_041146.1 49483922 2860166 complement(1821758..1821958) 1 NC_002952.2 Similar to Bacillus stearothermophilus 50S ribosomal protein L35 RpmI SW:RL35_BACST (P13069) (65 aa) fasta scores: E(): 1.8e-15, 72.13% id in 61 aa, and to Bacillus subtilis 50S ribosomal protein L35 RpmI SW:RL35_BACSU (P55874) (65 aa) fasta scores: E(): 9.1e-16, 70.76% id in 65 aa; 50S ribosomal protein L35 1821958 rpmI 2860166 rpmI Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L35 YP_041146.1 1821758 R 282458 CDS YP_041147.1 49483923 2859669 complement(1821987..1822514) 1 NC_002952.2 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1822514 infC 2859669 infC Staphylococcus aureus subsp. aureus MRSA252 translation initiation factor IF-3 YP_041147.1 1821987 R 282458 CDS YP_041148.1 49483924 2859814 complement(1822743..1824236) 1 NC_002952.2 Similar to Escherichia coli lysine-specific permease LysP SW:LYSP_ECOLI (P25737) (488 aa) fasta scores: E(): 2.4e-89, 51.77% id in 479 aa, and to Lactococcus lactis lysine specific permease LysP TR:Q9CDM6 (EMBL:AE006448) (506 aa) fasta scores: E(): 9.8e-99, 55.19% id in 491 aa; lysine-specific permease 1824236 lysP 2859814 lysP Staphylococcus aureus subsp. aureus MRSA252 lysine-specific permease YP_041148.1 1822743 R 282458 CDS YP_041149.1 49483925 2859532 complement(1824663..1826600) 1 NC_002952.2 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1826600 thrS 2859532 thrS Staphylococcus aureus subsp. aureus MRSA252 threonyl-tRNA synthetase YP_041149.1 1824663 R 282458 CDS YP_041150.1 49483926 2859602 complement(1827013..1827933) 1 NC_002952.2 Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 1827933 dnaI 2859602 dnaI Staphylococcus aureus subsp. aureus MRSA252 primosomal protein DnaI YP_041150.1 1827013 R 282458 CDS YP_041151.1 49483927 2859598 complement(1827933..1829333) 1 NC_002952.2 Similar to Bacillus subtilis replication initiation and membrane attachment protein DnaB SW:DNAB_BACSU (P07908) (472 aa) fasta scores: E(): 1.7e-18, 29% id in 462 aa, and to Bacillus halodurans chromosome replication initiation/membrane attachment protein BH3145 TR:Q9K862 (EMBL:AP001517) (485 aa) fasta scores: E(): 9e-08, 26.81% id in 481 aa; chromosome replication initiation/membrane attachment protein 1829333 dnaB 2859598 dnaB Staphylococcus aureus subsp. aureus MRSA252 chromosome replication initiation/membrane attachment protein YP_041151.1 1827933 R 282458 CDS YP_041152.1 49483928 2859417 complement(1829334..1829804) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3146 TR:Q9K861 (EMBL:AP001517) (153 aa) fasta scores: E(): 5.3e-30, 54.9% id in 153 aa, and to Streptococcus pyogenes hypothetical protein SPY0338 TR:Q9A1D3 (EMBL:AE006498) (164 aa) fasta scores: E(): 6.4e-30, 57.14% id in 147 aa; NrdR family transcriptional regulator 1829804 nrdR 2859417 nrdR Staphylococcus aureus subsp. aureus MRSA252 NrdR family transcriptional regulator YP_041152.1 1829334 R 282458 CDS YP_041153.1 49483929 2860689 complement(1830014..1831039) 1 NC_002952.2 Similar to Bacillus stearothermophilus glyceraldehyde 3-phosphate dehydrogenase Gap SW:G3P_BACST (P00362) (334 aa) fasta scores: E(): 1.6e-63, 54.21% id in 332 aa, and to Bacillus subtilis glyceraldehyde 3-phosphate dehydrogenase 2 GapB SW:G3P2_BACSU (O34425) (340 aa) fasta scores: E(): 3e-77, 62.17% id in 341 aa; glyceraldehyde 3-phosphate dehydrogenase 2 1831039 gap2 2860689 gap2 Staphylococcus aureus subsp. aureus MRSA252 glyceraldehyde 3-phosphate dehydrogenase 2 YP_041153.1 1830014 R 282458 CDS YP_041154.1 49483930 2859241 complement(1831209..1831832) 1 NC_002952.2 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 1831832 coaE 2859241 coaE Staphylococcus aureus subsp. aureus MRSA252 dephospho-CoA kinase YP_041154.1 1831209 R 282458 CDS YP_041155.1 49483931 2859418 complement(1831848..1832720) 1 NC_002952.2 Similar to Escherichia coli formamidopyrimidine-DNA glycosylase MutM SW:FPG_ECOLI (P05523) (269 aa) fasta scores: E(): 7.9e-21, 34.81% id in 293 aa, and to Caulobacter crescentus formamidopyrimidine-DNA glycosylase CC3707 TR:Q9A259 (EMBL:AE006028) (315 aa) fasta scores: E(): 9.2e-23, 31.02% id in 303 aa; formamidopyrimidine-DNA glycosylase 1832720 2859418 SAR1768 Staphylococcus aureus subsp. aureus MRSA252 formamidopyrimidine-DNA glycosylase YP_041155.1 1831848 R 282458 CDS YP_041156.1 49483932 2861011 complement(1832736..1835366) 1 NC_002952.2 Similar to Bacillus stearothermophilus DNA polymerase I PolA SW:DPO1_BACST (P52026) (876 aa) fasta scores: E(): 5.7e-169, 55.79% id in 880 aa, and to Bacillus subtilis DNA polymerase I PolA SW:DPO1_BACSU (O34996) (880 aa) fasta scores: E(): 2.2e-179, 59.68% id in 878 aa; DNA polymerase I 1835366 polA 2861011 polA Staphylococcus aureus subsp. aureus MRSA252 DNA polymerase I YP_041156.1 1832736 R 282458 CDS YP_041157.1 49483933 2861580 complement(1835659..1837146) 1 NC_002952.2 hypothetical protein 1837146 2861580 SAR1770 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041157.1 1835659 R 282458 CDS YP_041158.1 49483934 2859906 complement(1837647..1839311) 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Similar to Bacillus subtilis alkaline phosphatase synthesis sensor protein PhoR SW:PHOR_BACSU (P23545) (579 aa) fasta scores: E(): 6.3e-53, 35.06% id in 579 aa, and to Bacillus halodurans two-component sensor histidine kinase involved in phosphate regulation BH3156 TR:Q9K851 (EMBL:AP001517) (589 aa) fasta scores: E(): 6.4e-53, 34.63% id in 589 aa; alkaline phosphatase synthesis sensor protein 1839311 phoR 2859906 phoR Staphylococcus aureus subsp. aureus MRSA252 alkaline phosphatase synthesis sensor protein YP_041158.1 1837647 R 282458 CDS YP_041159.1 49483935 2859905 complement(1839311..1840012) 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Similar to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 1.9e-59, 67.51% id in 237 aa, and to Bacillus halodurans two-component response regulator involved in phosphate regulation BH3157 TR:Q9K850 (EMBL:AP001517) (239 aa) fasta scores: E(): 5.8e-56, 63.98% id in 236 aa. Similar to SAR0018, 52.155% identity (52.838% ungapped) in 232 aa overlap; alkaline phosphatase synthesis transcriptional regulatory protein 1840012 phoP 2859905 phoP Staphylococcus aureus subsp. aureus MRSA252 alkaline phosphatase synthesis transcriptional regulatory protein YP_041159.1 1839311 R 282458 CDS YP_041160.1 49483936 2861358 complement(1840402..1841670) 1 NC_002952.2 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1841670 citC 2861358 citC Staphylococcus aureus subsp. aureus MRSA252 isocitrate dehydrogenase YP_041160.1 1840402 R 282458 CDS YP_041161.1 49483937 2861360 complement(1841719..1842840) 1 NC_002952.2 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase 1842840 citZ 2861360 citZ Staphylococcus aureus subsp. aureus MRSA252 citrate synthase YP_041161.1 1841719 R 282458 CDS YP_041162.1 49483938 2859255 1843188..1844549 1 NC_002952.2 Similar to Escherichia coli D-serine/D-alanine/glycine transporter CycA SW:CYCA_ECOLI (P39312) (470 aa) fasta scores: E(): 9.9e-92, 52.22% id in 450 aa, and to Bacillus subtilis hypothetical transport protein YdgF SW:YDGF_BACSU (P96704) (458 aa) fasta scores: E(): 1.3e-86, 50.22% id in 440 aa. Smilar to SAR2528, 65.410% identity (65.556% ungapped) in 451 aa overlap; D-serine/D-alanine/glycine transporter 1844549 cycA 2859255 cycA Staphylococcus aureus subsp. aureus MRSA252 D-serine/D-alanine/glycine transporter YP_041162.1 1843188 D 282458 CDS YP_041163.1 49483939 2861244 complement(1844896..1846653) 1 NC_002952.2 Similar to Bacillus licheniformis pyruvate kinase Pyk SW:KPYK_BACLI (P51181) (585 aa) fasta scores: E(): 2.9e-125, 62.28% id in 586 aa, and to Escherichia coli, and pyruvate kinase I PykF SW:KPY1_ECOLI (P14178) (470 aa) fasta scores: E(): 9.9e-72, 48.53% id in 478 aa; pyruvate kinase 1846653 pyk 2861244 pyk Staphylococcus aureus subsp. aureus MRSA252 pyruvate kinase YP_041163.1 1844896 R 282458 CDS YP_041164.1 49483940 2859897 complement(1846675..1847643) 1 NC_002952.2 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1847643 pfkA 2859897 pfkA Staphylococcus aureus subsp. aureus MRSA252 6-phosphofructokinase YP_041164.1 1846675 R 282458 CDS YP_041165.1 49483941 2859052 complement(1847912..1848856) 1 NC_002952.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 1848856 accA 2859052 accA Staphylococcus aureus subsp. aureus MRSA252 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_041165.1 1847912 R 282458 CDS YP_041166.1 49483942 2859055 complement(1848856..1849713) 1 NC_002952.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 1849713 accD 2859055 accD Staphylococcus aureus subsp. aureus MRSA252 acetyl-CoA carboxylase subunit beta YP_041166.1 1848856 R 282458 CDS YP_041167.1 49483943 2861581 complement(1849908..1851137) 1 NC_002952.2 Similar to the C-terminal region of Bacillus stearothermophilus NAD-dependent malic enzyme SW:MAOX_BACST (P16468) (478 aa) fasta scores: E(): 2.8e-76, 56.64% id in 399 aa, and to the full length Bacillus subtilis hypothetical protein YtsJ TR:O34962 (EMBL:AF008220) (410 aa) fasta scores: E(): 8.1e-111, 74.38% id in 406 aa; NAD-dependent malic enzyme 1851137 2861581 SAR1780 Staphylococcus aureus subsp. aureus MRSA252 NAD-dependent malic enzyme YP_041167.1 1849908 R 282458 CDS YP_041168.1 49483944 2859600 complement(1851585..1854782) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus DNA polymerase III alpha subunit DnaE SW:DP3A_STAAU (Q9F1K0) (1065 aa) fasta scores: E(): 0, 96.71% id in 1065 aa. Similar to Bacillus subtilis DNA polymerase III alpha subunit DnaE SW:DP3A_BACSU (O34623) (1115 aa) fasta scores: E(): 2.1e-131, 40.62% id in 1083 aa; DNA polymerase III subunit alpha 1854782 dnaE 2859600 dnaE Staphylococcus aureus subsp. aureus MRSA252 DNA polymerase III subunit alpha YP_041168.1 1851585 R 282458 CDS YP_041169.1 49483945 2861582 complement(1854803..1855744) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtqI TR:O34600 (EMBL:AF008220) (313 aa) fasta scores: E(): 2.7e-56, 49.5% id in 305 aa, and to Bacillus halodurans hypothetical protein BH3173 TR:Q9K834 (EMBL:AP001518) (314 aa) fasta scores: E(): 1.7e-52, 45.57% id in 305 aa; hypothetical protein 1855744 2861582 SAR1782 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041169.1 1854803 R 282458 CDS YP_041170.1 49483946 2861583 complement(1856055..1857353) 1 NC_002952.2 Similar to Bacillus halodurans BH3175 TR:Q9K832 (EMBL:AP001518) (435 aa) fasta scores: E(): 1.5e-76, 47.11% id in 433 aa, and to Bacillus subtilis YtoI TR:O34921 (EMBL:AF008220) (439 aa) fasta scores: E(): 5.7e-72, 45.74% id in 435 aa; DNA-binding protein 1857353 2861583 SAR1783 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_041170.1 1856055 R 282458 CDS YP_041171.1 49483947 2861584 1857558..1857971 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0415 TR:Q9KFR2 (EMBL:AP001508) (137 aa) fasta scores: E(): 6.7e-08, 32.35% id in 136 aa, and to Sulfolobus solfataricus hypothetical protein SSO2778 TR:AAK42888 (EMBL:AE006871) (139 aa) fasta scores: E(): 0.0003, 26.42% id in 140 aa; universal stress protein 1857971 2861584 SAR1784 Staphylococcus aureus subsp. aureus MRSA252 universal stress protein YP_041171.1 1857558 D 282458 CDS YP_041172.1 49483948 2861585 complement(1858278..1858967) 1 NC_002952.2 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins; metal-dependent hydrolase 1858967 2861585 SAR1785 Staphylococcus aureus subsp. aureus MRSA252 metal-dependent hydrolase YP_041172.1 1858278 R 282458 CDS YP_041173.1 49483949 2861586 1859142..1860197 1 NC_002952.2 Similar to Lactobacillus delbrueckii Xaa-Pro dipeptidase PepQ SW:PEPQ_LACDE (Q9S6S1) (368 aa) fasta scores: E(): 7.1e-40, 43.13% id in 357 aa, and to Bacillus halodurans prolidase BH3179 TR:Q9K828 (EMBL:AP001518) (364 aa) fasta scores: E(): 3.5e-58, 43.01% id in 358 aa; metallopeptidase 1860197 2861586 SAR1786 Staphylococcus aureus subsp. aureus MRSA252 metallopeptidase YP_041173.1 1859142 D 282458 CDS YP_041174.1 49483950 2860988 complement(1860507..1861625) 1 NC_002952.2 Similar to Bacillus subtilis alanine dehydrogenase Ald SW:DHA_BACSU (Q08352) (378 aa) fasta scores: E(): 4.4e-83, 66.3% id in 371 aa, and to Enterobacter aerogenes alanine dehydrogenase AlaDH TR:Q9WX54 (EMBL:AB013821) (377 aa) fasta scores: E(): 1.1e-84, 65.76% id in 371 aa; alanine dehydrogenase 1861625 ald1 2860988 ald1 Staphylococcus aureus subsp. aureus MRSA252 alanine dehydrogenase YP_041174.1 1860507 R 282458 CDS YP_041175.1 49483951 2861587 1861766..1862266 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YtaA TR:Q9CEK4 (EMBL:AE006413) (145 aa) fasta scores: E(): 9.2e-22, 48.57% id in 140 aa, and to Bacillus halodurans hypothetical protein BH3184 TR:Q9K823 (EMBL:AP001518) (147 aa) fasta scores: E(): 3.6e-21, 48.95% id in 143 aa; universal stress protein 1862266 2861587 SAR1788 Staphylococcus aureus subsp. aureus MRSA252 universal stress protein YP_041175.1 1861766 D 282458 CDS YP_041176.1 49483952 2859056 complement(1862513..1863715) 1 NC_002952.2 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1863715 ackA 2859056 ackA Staphylococcus aureus subsp. aureus MRSA252 acetate kinase YP_041176.1 1862513 R 282458 CDS YP_041177.1 49483953 2861588 complement(1863802..1864749) 1 NC_002952.2 Similar to the C-terminal region of Escherichia coli type I restriction enzyme EcoEI M protein HsdM SW:T1ME_ECOLI (Q47282) (490 aa) fasta scores: E(): 0.002, 23.94% id in 309 aa, and to the full length Bacillus subtilis hypothetical protein YtxK SW:YTXK_BACSU (P37876) (329 aa) fasta scores: E(): 3.4e-33, 35.09% id in 322 aa; hypothetical protein 1864749 2861588 SAR1790 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041177.1 1863802 R 282458 CDS YP_041178.1 49483954 2861589 complement(1864872..1865366) 1 NC_002952.2 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1865366 tpx 2861589 tpx Staphylococcus aureus subsp. aureus MRSA252 thiol peroxidase YP_041178.1 1864872 R 282458 CDS YP_041179.1 49483955 2861590 complement(1865464..1866234) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2122 TR:Q9KB14 (EMBL:AP001514) (259 aa) fasta scores: E(): 1.4e-41, 49.21% id in 256 aa, and to Pasteurella multocida hypothetical protein PM0361 TR:Q9CNR5 (EMBL:AE006072) (254 aa) fasta scores: E(): 1.1e-26, 33.98% id in 256 aa; hypothetical protein 1866234 2861590 SAR1792 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041179.1 1865464 R 282458 CDS YP_041180.1 49483956 2859527 complement(1866278..1867501) 1 NC_002952.2 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 1867501 thiI 2859527 thiI Staphylococcus aureus subsp. aureus MRSA252 thiamine biosynthesis protein ThiI YP_041180.1 1866278 R 282458 CDS YP_041181.1 49483957 2861591 complement(1867501..1868640) 1 NC_002952.2 Similar to Escherichia coli cysteine desulfurase IscS SW:ISCS_ECOLI (P39171) (404 aa) fasta scores: E(): 3.5e-36, 38.14% id in 367 aa, and to Bacillus halodurans L-cysteine sulfurtransferase BZ3204 TR:Q9K803 (EMBL:AP001518) (380 aa) fasta scores: E(): 2.8e-46, 37.69% id in 382 aa; aminotransferase class-V protein 1868640 2861591 SAR1794 Staphylococcus aureus subsp. aureus MRSA252 aminotransferase class-V protein YP_041181.1 1867501 R 282458 CDS YP_041182.1 49483958 2861592 complement(1869008..1870702) 1 NC_002952.2 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 1870702 2861592 SAR1795 Staphylococcus aureus subsp. aureus MRSA252 septation ring formation regulator EzrA YP_041182.1 1869008 R 282458 CDS YP_041183.1 49483959 2861593 1870839..1871303 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3208 TR:Q9K7Z9 (EMBL:AP001518) (160 aa) fasta scores: E(): 1.6e-31, 56.55% id in 145 aa, and to Xylella fastidiosa hypothetical protein XF1230 TR:Q9PDZ8 (EMBL:AE003957) (162 aa) fasta scores: E(): 2e-28, 48.36% id in 153 aa; hypothetical protein 1871303 2861593 SAR1796 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041183.1 1870839 D 282458 CDS YP_041184.1 49483960 2860175 1871547..1872149 1 NC_002952.2 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1872149 rpsD 2860175 rpsD Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S4 YP_041184.1 1871547 D 282458 CDS YP_041185.1 49483961 2861594 complement(1872365..1873108) 1 NC_002952.2 Similar to Bacillus subtilis glycerophosphoryl diester phosphodiesterase GlpQ SW:GLPQ_BACSU (P37965) (293 aa) fasta scores: E(): 1.1e-14, 33.59% id in 256 aa, and to Bacillus subtilis hypothetical protein YhdW TR:O07592 (EMBL:Y14082) (243 aa) fasta scores: E(): 3.7e-25, 35.41% id in 240 aa; hypothetical protein 1873108 2861594 SAR1798 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041185.1 1872365 R 282458 CDS YP_041186.1 49483962 2861595 1873188..1873634 1 NC_002952.2 Similar to Xanthomonas campestris organic hydroperoxide resistance protein Ohr SW:OHR_XANCH (O68390) (142 aa) fasta scores: E(): 0.00011, 27.85% id in 140 aa, and to Bacillus subtilis hypothetical protein YmaD TR:O31790 (EMBL:Z99113) (150 aa) fasta scores: E(): 2.6e-17, 38.29% id in 141 aa; OsmC-like protein 1873634 2861595 SAR1799 Staphylococcus aureus subsp. aureus MRSA252 OsmC-like protein YP_041186.1 1873188 D 282458 CDS YP_041187.1 49483963 2861596 1873749..1874909 1 NC_002952.2 Similar to Synechococcus sp soluble hydrogenase, small subunit SW:DHSS_SYNP1 (P14776) (384 aa) fasta scores: E(): 2.2e-50, 39.68% id in 383 aa, and to Anabaena cylindrica soluble hydrogenase subunit SW:DHSS_ANACY (P16421) (383 aa) fasta scores: E(): 1.6e-49, 38.25% id in 379 aa; soluble hydrogenase subunit 1874909 2861596 SAR1800 Staphylococcus aureus subsp. aureus MRSA252 soluble hydrogenase subunit YP_041187.1 1873749 D 282458 CDS YP_041188.1 49483964 2861597 1874896..1876500 1 NC_002952.2 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 1876500 2861597 SAR1801 Staphylococcus aureus subsp. aureus MRSA252 D-3-phosphoglycerate dehydrogenase YP_041188.1 1874896 D 282458 CDS YP_041189.1 49483965 2861598 complement(1876650..1877780) 1 NC_002952.2 hypothetical protein 1877780 2861598 SAR1802 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041189.1 1876650 R 282458 CDS YP_041190.1 49483966 2861599 complement(1877886..1879352) 1 NC_002952.2 Similar to N-terminal region of Escherichia coli PTS system, N-acetylglucosamine-specific IIABC component NagE SW:PTAA_ECOLI (P09323) (648 aa) fasta scores: E(): 6.8e-53, 41.58% id in 493 aa, and to full length Pasteurella multocida hypothetical protein PM0876 TR:Q9CMF3 (EMBL:AE006126) (485 aa) fasta scores: E(): 2.1e-77, 48.58% id in 496 aa; PTS system IIBC component 1879352 2861599 SAR1803 Staphylococcus aureus subsp. aureus MRSA252 PTS system IIBC component YP_041190.1 1877886 R 282458 CDS YP_041191.1 49483967 2861600 complement(1879480..1880097) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhdO TR:O07584 (EMBL:Y14082) (199 aa) fasta scores: E(): 3.4e-31, 47.03% id in 202 aa, and to Lactococcus lactis hypothetical protein YbbE TR:Q9CJ88 (EMBL:AE006249) (213 aa) fasta scores: E(): 5.1e-18, 37.81% id in 201 aa; acyltransferase 1880097 2861600 SAR1804 Staphylococcus aureus subsp. aureus MRSA252 acyltransferase YP_041191.1 1879480 R 282458 CDS YP_041192.1 49483968 2861601 1880269..1881543 1 NC_002952.2 Similar to Lactobacillus helveticus trypsin-like serine protease HtrA TR:Q9Z4H7 (EMBL:AJ005672) (412 aa) fasta scores: E(): 1.7e-40, 41.88% id in 413 aa, and to Bacillus subtilis hypothetical protein YkdA TR:O34358 (EMBL:AJ002571) (449 aa) fasta scores: E(): 6.2e-39, 39.37% id in 419 aa; protease 1881543 2861601 SAR1805 Staphylococcus aureus subsp. aureus MRSA252 protease YP_041192.1 1880269 D 282458 CDS YP_041193.1 49483969 2860409 complement(1881637..1882899) 1 NC_002952.2 Similar to Bacillus stearothermophilus tyrosyl-tRNA synthetase TyrS SW:SYY_BACST (P00952) (419 aa) fasta scores: E(): 4.8e-101, 61.05% id in 416 aa, and to Bacillus caldotenax tyrosyl-tRNA synthetase TyrS SW:SYY_BACCA (P04077) (419 aa) fasta scores: E(): 2.6e-100, 60.81% id in 416 aa; tyrosyl-tRNA synthetase 1882899 tyrS 2860409 tyrS Staphylococcus aureus subsp. aureus MRSA252 tyrosyl-tRNA synthetase YP_041193.1 1881637 R 282458 CDS YP_041194.1 49483970 2861602 1883280..1884185 1 NC_002952.2 Possible gene remnant. Similar to the N-terminal regions of Bacillus subtilis penicillin-binding protein 1A/1B PonA SW:PBPA_BACSU (P39793) (914 aa) fasta scores: E(): 3.6e-15, 32.23% id in 273 aa, and Streptococcus pyogenes penicillin-binding protein 1B SPY0097 TR:Q9A1U2 (EMBL:AE006480) (770 aa) fasta scores: E(): 4.5e-32, 37.73% id in 265 aa. Full length CDS is similar to Staphylococcus epidermidis SgtA protein SE1407 SWALL:Q8CNW0 (EMBL:AE016748) (301 aa) fasta scores: E(): 2.1e-70, 63.63% id in 297 aa; transglycosylase 1884185 2861602 SAR1807 Staphylococcus aureus subsp. aureus MRSA252 transglycosylase YP_041194.1 1883280 D 282458 CDS YP_041195.1 49483971 2861603 1887056..1887151 1 NC_002952.2 Doubtful CDS; hypothetical protein 1887151 2861603 SAR1809a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041195.1 1887056 D 282458 CDS YP_041196.1 49483972 2860663 complement(1887397..1889064) 1 NC_002952.2 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1889064 fhs 2860663 fhs Staphylococcus aureus subsp. aureus MRSA252 formate--tetrahydrofolate ligase YP_041196.1 1887397 R 282458 CDS YP_041197.1 49483973 2859059 complement(1889504..1891210) 1 NC_002952.2 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 1891210 acsA 2859059 acsA Staphylococcus aureus subsp. aureus MRSA252 acetyl-CoA synthetase YP_041197.1 1889504 R 282458 CDS YP_041198.1 49483974 2859060 1891379..1892011 1 NC_002952.2 Similar to Bacillus subtilis acetoin utilization protein AcuA SW:ACUA_BACSU (P39065) (210 aa) fasta scores: E(): 1.4e-43, 51.9% id in 210 aa, and to Bacillus halodurans acetoin dehydrogenase BH3235 TR:Q9K7X3 (EMBL:AP001518) (210 aa) fasta scores: E(): 1.2e-44, 52.85% id in 210 aa; acetoin utilization protein 1892011 acuA 2859060 acuA Staphylococcus aureus subsp. aureus MRSA252 acetoin utilization protein YP_041198.1 1891379 D 282458 CDS YP_041199.1 49483975 2861604 1892036..1893205 1 NC_002952.2 Similar to Bacillus subtilis acetoin utilization protein AcuC SW:ACUC_BACSU (P39067) (387 aa) fasta scores: E(): 5.6e-74, 48.38% id in 372 aa, and to Staphylococcus xylosus acetoin utilization protein AcuC SW:ACUC_STAXY (Q56195) (385 aa) fasta scores: E(): 2.2e-113, 68.05% id in 385 aa; histone deacetylase 1893205 2861604 SAR1813 Staphylococcus aureus subsp. aureus MRSA252 histone deacetylase YP_041199.1 1892036 D 282458 CDS YP_041200.1 49483976 2861352 complement(1893303..1894292) 1 NC_002952.2 Similar to Bacillus subtilis catabolite control protein A CcpA SW:CCPA_BACSU (P25144) (334 aa) fasta scores: E(): 1.7e-56, 53.93% id in 330 aa, and to Staphylococcus xylosus probable catabolite control protein A CcpA SW:CCPA_STAXY (Q56194) (329 aa) fasta scores: E(): 4e-92, 80.85% id in 329 aa; catabolite control protein A 1894292 ccpA 2861352 ccpA Staphylococcus aureus subsp. aureus MRSA252 catabolite control protein A YP_041200.1 1893303 R 282458 CDS YP_041201.1 49483977 2861605 complement(1894832..1895923) 1 NC_002952.2 catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate; bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase 1895923 2861605 SAR1815 Staphylococcus aureus subsp. aureus MRSA252 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase YP_041201.1 1894832 R 282458 CDS YP_041202.1 49483978 2861606 complement(1896617..1897807) 1 NC_002952.2 No significant database matches. CDS contains an imperfect 54 amino repeat region, residues 99 to 206; hypothetical protein 1897807 2861606 SAR1816 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041202.1 1896617 R 282458 CDS YP_041203.1 49483979 2861607 complement(1897881..1898372) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtxG SW:YTXG_BACSU (P40779) (143 aa) fasta scores: E(): 2.7e-17, 48.148% id in 135 aa, and to Bacillus halodurans general stress protein BH3245 TR:Q9K7W3 (EMBL:AP001518) (148 aa) fasta scores: E(): 7.3e-15, 42.222% id in 135 aa; hypothetical protein 1898372 2861607 SAR1817 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041203.1 1897881 R 282458 CDS YP_041204.1 49483980 2861321 complement(1898446..1899759) 1 NC_002952.2 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1899759 murC 2861321 murC Staphylococcus aureus subsp. aureus MRSA252 UDP-N-acetylmuramate--L-alanine ligase YP_041204.1 1898446 R 282458 CDS YP_041205.1 49483981 2861608 complement(1899783..1903607) 1 NC_002952.2 C-terminus is similar to the C-terminal regions of Bacillus subtilis stage III sporulation protein E SpoIIIE SW:SP3E_BACSU (P21458) (787 aa) fasta scores: E(): 8.8e-56, 47.784% id in 519 aa, and Bacillus halodurans DNA translocase BH3250 TR:Q9K7V9 (EMBL:AP001518) (960 aa) fasta scores: E(): 5.4e-80, 42.638% id in 849 aa; FtsK/SpoIIIE family protein 1903607 2861608 SAR1819 Staphylococcus aureus subsp. aureus MRSA252 FtsK/SpoIIIE family protein YP_041205.1 1899783 R 282458 CDS YP_041206.1 49483982 2861609 complement(1903628..1904266) 1 NC_002952.2 C-terminus is similar to the N-terminal region of Bacillus subtilis phenylalanyl-tRNA synthetase beta chain hypothetical protein PheT SW:SYFB_BACSU (P17922) (804 aa) fasta scores: E(): 4.8e-12, 41.985% id in 131 aa, and to full length Bacillus subtilis YtpR TR:O34943 (EMBL:AF008220) (201 aa) fasta scores: E(): 1.3e-33, 57.346% id in 211 aa. CDS contain additional amino acids, residues 51 to 64, compared to orthologues; the effect on the function of protein is not known; hypothetical protein 1904266 2861609 SAR1820 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041206.1 1903628 R 282458 CDS YP_041207.1 49483983 2861610 complement(1904295..1905152) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtpQ TR:O34496 (EMBL:AF008220) (269 aa) fasta scores: E(): 3e-50, 52.239% id in 268 aa, and to Bacillus halodurans hypothetical protein BH3252 TR:Q9K7V7 (EMBL:AP001518) (265 aa) fasta scores: E(): 3.8e-41, 44.528% id in 265 aa; hypothetical protein 1905152 2861610 SAR1821 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041207.1 1904295 R 282458 CDS YP_041208.1 49483984 2861611 complement(1905252..1905563) 1 NC_002952.2 Similar to Schizosaccharomyces pombe thioredoxin II TRX2 SW:TRX2_SCHPO (O14463) (102 aa) fasta scores: E(): 2.1e-07, 31.579% id in 95 aa, and to Bacillus subtilis thioredoxin YtpP TR:O34357 (EMBL:AF008220) (107 aa) fasta scores: E(): 1.3e-18, 51.000% id in 100 aa; thioredoxin 1905563 2861611 SAR1822 Staphylococcus aureus subsp. aureus MRSA252 thioredoxin YP_041208.1 1905252 R 282458 CDS YP_041209.1 49483985 2861612 complement(1905628..1906704) 1 NC_002952.2 Similar to Lactococcus lactis glutamyl-aminopeptidase PepA SW:PEPA_LACLC (Q48677) (355 aa) fasta scores: E(): 2.2e-51, 41.690% id in 355 aa, and to Bacillus subtilis hypothetical protein YtoP TR:O34924 (EMBL:AF008220) (357 aa) fasta scores: E(): 8e-61, 44.957% id in 347 aa; aminopeptidase 1906704 2861612 SAR1823 Staphylococcus aureus subsp. aureus MRSA252 aminopeptidase YP_041209.1 1905628 R 282458 CDS YP_041210.1 49483986 2861613 1906791..1907102 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtzB TR:O32065 (EMBL:Z99119) (105 aa) fasta scores: E(): 0.032, 25.243% id in 103 aa, and to Bacillus halodurans hypothetical protein BH3258 TR:Q9K7V1 (EMBL:AP001518) (102 aa) fasta scores: E(): 0.078, 25.532% id in 94 aa; hypothetical protein 1907102 2861613 SAR1824 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041210.1 1906791 D 282458 CDS YP_041211.1 49483987 2861614 complement(1907226..1908068) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3260 TR:Q9K7U9 (EMBL:AP001518) (284 aa) fasta scores: E(): 1.3e-56, 51.481% id in 270 aa, and to Bacillus subtilis hypothetical protein YtnP TR:O34760 (EMBL:AF008220) (256 aa) fasta scores: E(): 7.7e-50, 51.181% id in 254 aa; metallo-beta-lactamase superfamily protein 1908068 2861614 SAR1825 Staphylococcus aureus subsp. aureus MRSA252 metallo-beta-lactamase superfamily protein YP_041211.1 1907226 R 282458 CDS YP_041212.1 49483988 2861615 complement(1908514..1909329) 1 NC_002952.2 Highly similar to Staphylococcus aureus potential ATP-binding protein SW:ATBP_STAAU (P18179) (271 aa) fasta scores: E(): 5.9e-103, 99.631% id in 271 aa; ATP-binding protein 1909329 2861615 SAR1826 Staphylococcus aureus subsp. aureus MRSA252 ATP-binding protein YP_041212.1 1908514 R 282458 CDS YP_041213.1 49483989 2861616 complement(1909322..1910764) 1 NC_002952.2 Identical to Staphylococcus aureus transposase for transposon Tn552 SW:TRA3_STAAU (P18416) (480 aa) fasta scores: E(): 1.2e-189, 100.000% id in 480 aa. Similar to Rhizobium loti transposase MLR6273 TR:BAB52595 (EMBL:AP003008) (535 aa) fasta scores: E(): 3.6e-12, 24.486% id in 486 aa; transposase 1910764 2861616 SAR1827 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_041213.1 1909322 R 282458 CDS YP_041214.1 49483990 2859543 complement(1910736..1911329) 1 NC_002952.2 Similar to Staphylococcus aureus transposon Tn552 resolvase TnpR SW:BINL_STAAU (P18358) (197 aa) fasta scores: E(): 2.1e-72, 98.477% id in 197 aa, and to Lactococcus lactis resolvase TnpR TR:Q9R778 (EMBL:X92946) (183 aa) fasta scores: E(): 2.5e-55, 79.781% id in 183 aa; resolvase 1911329 tnpR 2859543 tnpR Staphylococcus aureus subsp. aureus MRSA252 resolvase YP_041214.1 1910736 R 282458 CDS YP_041215.1 49483991 2858973 complement(1911593..1911973) 1 NC_002952.2 Identical to Staphylococcus aureus penicillinase repressor BlaI SW:BLAI_STAAU (P18415) (126 aa) fasta scores: E(): 1.6e-40, 100.000% id in 126 aa. Similar to Bacillus licheniformis penicillinase repressor blaI SW:BLAI_BACLI (P06555) (128 aa) fasta scores: E(): 1.1e-11, 41.026% id in 117 aa; penicillinase repressor 1911973 blaI 2858973 blaI Staphylococcus aureus subsp. aureus MRSA252 penicillinase repressor YP_041215.1 1911593 R 282458 CDS YP_041216.1 49483992 2858974 complement(1911963..1913720) 1 NC_002952.2 Highly similar to Staphylococcus aureus beta-lactamase regulatory protein BlaR1 SW:BLAR_STAAU (P18357) (585 aa) fasta scores: E(): 0, 99.145% id in 585 aa. Similar to Bacillus licheniformis regulatory protein BlaR1 SW:BLAR_BACLI (P12287) (601 aa) fasta scores: E(): 4.7e-45, 27.703% id in 592 aa; beta-lactamase regulatory protein 1913720 blaR1 2858974 blaR1 Staphylococcus aureus subsp. aureus MRSA252 beta-lactamase regulatory protein YP_041216.1 1911963 R 282458 CDS YP_041217.1 49483993 2859819 1913827..1914672 1 NC_002952.2 Similar to Staphylococcus aureus beta-lactamase precursor BlaZ SW:BLAC_STAAU (P00807) (281 aa) fasta scores: E(): 2.6e-94, 99.644% id in 281 aa, and to Bacillus licheniformis beta-lactamase precursor PenP SW:BLAC_BACLI (P00808) (307 aa) fasta scores: E(): 8.9e-36, 40.956% id in 293 aa; beta-lactamase precursor 1914672 blaZ 2859819 blaZ Staphylococcus aureus subsp. aureus MRSA252 beta-lactamase precursor YP_041217.1 1913827 D 282458 CDS YP_041218.1 49483994 2861617 1914968..1915084 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 1915084 2861617 SAR1832 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041218.1 1914968 D 282458 CDS YP_041219.1 49483995 2861618 complement(1915146..1915790) 1 NC_002952.2 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 1915790 trmB 2861618 trmB Staphylococcus aureus subsp. aureus MRSA252 tRNA (guanine-N(7)-)-methyltransferase YP_041219.1 1915146 R 282458 CDS YP_041220.1 49483996 2860334 complement(1915805..1916596) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3263 TR:Q9K7U6 (EMBL:AP001518) (261 aa) fasta scores: E(): 2e-50, 47.308% id in 260 aa, and to Bacillus subtilis hypothetical protein YtmP TR:O34935 (EMBL:AF008220) (269 aa) fasta scores: E(): 9.4e-48, 46.693% id in 257 aa; hypothetical protein 1916596 2860334 SAR1834 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041220.1 1915805 R 282458 CDS YP_041221.1 49483997 2859265 complement(1917147..1917995) 1 NC_002952.2 Similar to Listeria monocytogenes D-alanine aminotransferase Dat SW:DAAA_LISMO (O85046) (289 aa) fasta scores: E(): 1.8e-48, 51.986% id in 277 aa, and to Staphylococcus haemolyticus D-alanine aminotransferase Dat SW:DAAA_STAHA (P54694) (282 aa) fasta scores: E(): 2e-88, 80.071% id in 281 aa; D-alanine aminotransferase 1917995 dat 2859265 dat Staphylococcus aureus subsp. aureus MRSA252 D-alanine aminotransferase YP_041221.1 1917147 R 282458 CDS YP_041222.1 49483998 2860335 complement(1917999..1919408) 1 NC_002952.2 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 1919408 2860335 SAR1836 Staphylococcus aureus subsp. aureus MRSA252 dipeptidase PepV YP_041222.1 1917999 R 282458 CDS YP_041223.1 49483999 2860336 complement(1919614..1920036) 1 NC_002952.2 Similar to the N-terminal region of Neisseria meningitidis hypothetical protein NMA2141 TR:Q9JST6 (EMBL:AL162758) (239 aa) fasta scores: E(): 1.8, 23.387% id in 124 aa. N-terminus is similar to the N-terminal region of Streptococcus pyogenes hypothetical protein SPY0588 TR:Q9A0W2 (EMBL:AE006514) (142 aa) fasta scores: E(): 2, 28.302% id in 106 aa; hypothetical protein 1920036 2860336 SAR1837 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041223.1 1919614 R 282458 CDS YP_041224.1 49484000 2860337 complement(1920053..1920748) 1 NC_002952.2 Similar to Escherichia coli ribosomal small subunit pseudouridine synthase A RsuA SW:RSUA_ECOLI (P33918) (231 aa) fasta scores: E(): 2.1e-23, 37.004% id in 227 aa, and to Bacillus halodurans 16S pseudouridylate synthase BH3273 TR:Q9K7T6 (EMBL:AP001518) (238 aa) fasta scores: E(): 6.2e-41, 56.332% id in 229 aa; RNA pseudouridine synthase 1920748 2860337 SAR1838 Staphylococcus aureus subsp. aureus MRSA252 RNA pseudouridine synthase YP_041224.1 1920053 R 282458 CDS YP_041225.1 49484001 2860338 complement(1920745..1922406) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtgP TR:O34674 (EMBL:AF008220) (544 aa) fasta scores: E(): 7.6e-68, 36.015% id in 547 aa, and to Bacillus subtilis stage V sporulation protein B SpoVB SW:SP5B_BACSU (Q00758) (518 aa) fasta scores: E(): 6.4e-05, 21.124% id in 516 aa; polysaccharide biosynthesis protein 1922406 2860338 SAR1839 Staphylococcus aureus subsp. aureus MRSA252 polysaccharide biosynthesis protein YP_041225.1 1920745 R 282458 CDS YP_041226.1 49484002 2860339 1922810..1924078 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtfP TR:O30505 (EMBL:AF008220) (405 aa) fasta scores: E(): 3.1e-85, 58.231% id in 407 aa, and to Bacillus halodurans hypothetical protein BH3279 TR:Q9K7T0 (EMBL:AP001518) (422 aa) fasta scores: E(): 1e-83, 54.893% id in 419 aa; hypothetical protein 1924078 2860339 SAR1840 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041226.1 1922810 D 282458 CDS YP_041227.1 49484003 2859120 complement(1924195..1930764) 1 NC_002952.2 Similar to Staphylococcus aureus hypothetical protein affecting the methicillin resistance Mrp TR:Q9RL69 (EMBL:Y09927) (2478 aa) fasta scores: E(): 2e-139, 32.553% id in 2178 aa, and to Abiotrophia defectiva extracellular matrix binding protein Emb TR:O85472 (EMBL:AF067776) (2055 aa) fasta scores: E(): 1.8e-62, 25.954% id in 2096 aa. Probable LPXTG-sorted surface protein; surface anchored protein 1930764 sasC 2859120 sasC Staphylococcus aureus subsp. aureus MRSA252 surface anchored protein YP_041227.1 1924195 R 282458 CDS YP_041228.1 49484004 2860340 complement(1931088..1931399) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YhjC TR:Q9CHE7 (EMBL:AE006312) (102 aa) fasta scores: E(): 6.9e-08, 38.710% id in 93 aa, and to Neisseria meningitidis hypothetical protein NMB1884 TR:Q9JXU1 (EMBL:AE002538) (107 aa) fasta scores: E(): 1.8e-07, 38.889% id in 90 aa; hypothetical protein 1931399 2860340 SAR1842 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041228.1 1931088 R 282458 CDS YP_041229.1 49484005 2859801 complement(1931421..1933835) 1 NC_002952.2 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1933835 leuS 2859801 leuS Staphylococcus aureus subsp. aureus MRSA252 leucyl-tRNA synthetase YP_041229.1 1931421 R 282458 CDS YP_041230.1 49484006 2860341 complement(1934127..1935308) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YttB TR:O34546 (EMBL:AF008220) (397 aa) fasta scores: E(): 5.6e-71, 51.918% id in 391 aa, and to Bacillus halodurans multidrug resistance protein BH3282 TR:Q9K7S7 (EMBL:AP001518) (401 aa) fasta scores: E(): 2.1e-68, 51.459% id in 377 aa; hypothetical protein 1935308 2860341 SAR1844 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041230.1 1934127 R 282458 CDS YP_041231.1 49484007 2860342 1935419..1936372 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtqA TR:O35008 (EMBL:AF008220) (322 aa) fasta scores: E(): 2.5e-94, 75.490% id in 306 aa, and to Bacillus halodurans hypothetical protein BH3284 TR:Q9K7S5 (EMBL:AP001518) (325 aa) fasta scores: E(): 7.4e-90, 69.805% id in 308 aa; hypothetical protein 1936372 2860342 SAR1845 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041231.1 1935419 D 282458 CDS YP_041232.1 49484008 2860343 1936369..1936932 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3285 TR:Q9K7S4 (EMBL:AP001518) (190 aa) fasta scores: E(): 2.1e-31, 52.381% id in 189 aa, and to Bacillus subtilis hypothetical protein YtqB TR:O34614 (EMBL:AF008220) (194 aa) fasta scores: E(): 1.2e-30, 51.596% id in 188 aa; hypothetical protein 1936932 2860343 SAR1846 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041232.1 1936369 D 282458 CDS YP_041233.1 49484009 2860897 complement(1937051..1937551) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus repressor of toxins Rot TR:Q9RFJ6 (EMBL:AF189239) (166 aa) fasta scores: E(): 5.7e-60, 97.590% id in 166 aa. Similar to Staphylococcus aureus SarR TR:Q9F0R1 (EMBL:AF207701) (115 aa) fasta scores: E(): 0.0043, 28.814% id in 118 aa. Probable alternative translational start sites; repressor of toxins 1937551 rot 2860897 rot Staphylococcus aureus subsp. aureus MRSA252 repressor of toxins YP_041233.1 1937051 R 282458 CDS YP_041234.1 49484010 2860344 complement(1938025..1938852) 1 NC_002952.2 Similar to Bacillus halodurans lysophospholipase BH3288 TR:Q9K7S1 (EMBL:AP001518) (260 aa) fasta scores: E(): 1e-28, 34.091% id in 264 aa, and to Bacillus subtilis probable lysophospholipase YtpA TR:O34705 (EMBL:AF008220) (259 aa) fasta scores: E(): 2e-27, 32.184% id in 261 aa; hypothetical protein 1938852 2860344 SAR1848 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041234.1 1938025 R 282458 CDS YP_041235.1 49484011 2860345 1939086..1940087 1 NC_002952.2 Similar to Bacillus halodurans proline oxidase BH2740 TR:Q9K9A9 (EMBL:AP001516) (306 aa) fasta scores: E(): 2e-44, 45.638% id in 298 aa, and to Bacillus subtilis hypothetical protein YusM TR:O32179 (EMBL:Z99120) (302 aa) fasta scores: E(): 1.1e-40, 42.244% id in 303 aa; proline dehydrogenase 1940087 2860345 SAR1849 Staphylococcus aureus subsp. aureus MRSA252 proline dehydrogenase YP_041235.1 1939086 D 282458 CDS YP_041236.1 49484012 2859270 complement(1940209..1940673) 1 NC_002952.2 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 1940673 ribH 2859270 ribH Staphylococcus aureus subsp. aureus MRSA252 6,7-dimethyl-8-ribityllumazine synthase YP_041236.1 1940209 R 282458 CDS YP_041237.1 49484013 2859308 complement(1940686..1941867) 1 NC_002952.2 Similar to Actinobacillus pleuropneumoniae riboflavin biosynthesis protein RibA [includes: GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase] RibA SW:GCH2_ACTPL (P50855) (401 aa) fasta scores: E(): 1.8e-77, 51.777% id in 394 aa, and to Bacillus halodurans GTP cyclohydrolase II/ 3, 4-dihydroxy-2-butanone 4-phosphate synthase BH1556 TR:Q9KCL5 (EMBL:AP001512) (404 aa) fasta scores: E(): 3.4e-79, 52.284% id in 394 aa; riboflavin biosynthesis protein 1941867 ribA 2859308 ribA Staphylococcus aureus subsp. aureus MRSA252 riboflavin biosynthesis protein YP_041237.1 1940686 R 282458 CDS YP_041238.1 49484014 2859269 complement(1941878..1942510) 1 NC_002952.2 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1942510 ribE 2859269 ribE Staphylococcus aureus subsp. aureus MRSA252 riboflavin synthase subunit alpha YP_041238.1 1941878 R 282458 CDS YP_041239.1 49484015 2859309 complement(1942517..1943560) 1 NC_002952.2 Similar to Escherichia coli riboflavin biosynthesis protein RibD [includes: diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5- phosphoribosylamino)uracil reductase] RibD SW:RIBD_ECOLI (P25539) (367 aa) fasta scores: E(): 1.4e-25, 34.444% id in 360 aa, and to Aquifex aeolicus riboflavin biosynthesis protein ribd [includes: diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5- phosphoribosylamino)uracil reductase] AQ_138 SW:RIBD_AQUAE (O66534) (356 aa) fasta scores: E(): 5.3e-41, 40.323% id in 310 aa; bifunctional riboflavin biosynthesis protein 1943560 ribD 2859309 ribD Staphylococcus aureus subsp. aureus MRSA252 bifunctional riboflavin biosynthesis protein YP_041239.1 1942517 R 282458 CDS YP_041240.1 49484016 2860346 complement(1944041..1945543) 1 NC_002952.2 Similar to Rhizobium loti hypothetical protein MLR5217 TR:BAB51703 (EMBL:AP003006) (486 aa) fasta scores: E(): 9.5e-05, 19.141% id in 512 aa, and to Rhizobium loti hypothetical protein MLL4514 TR:BAB51151 (EMBL:AP003004) (450 aa) fasta scores: E(): 0.0097, 19.798% id in 495 aa; hypothetical protein 1945543 2860346 SAR1854 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041240.1 1944041 R 282458 CDS YP_041241.1 49484017 2859868 1946186..1946500 1 NC_002952.2 Similar to Staphylococcus aureus arsenical resistance operon repressor ArsR SW:ARSR_STAAU (P30338) (104 aa) fasta scores: E(): 5.4e-32, 75.962% id in 104 aa, and to Bacillus subtilis arsenical resistance operon repressor ArsR SW:ARSR_BACSU (P45949) (105 aa) fasta scores: E(): 2.1e-06, 38.542% id in 96 aa. Similar to SAR0690, 75.000% identity (75.000% ungapped) in 104 aa overlap; arsenical resistance operon repressor 2 1946500 arsR2 2859868 arsR2 Staphylococcus aureus subsp. aureus MRSA252 arsenical resistance operon repressor 2 YP_041241.1 1946186 D 282458 CDS YP_041242.1 49484018 2859865 1946500..1947792 1 NC_002952.2 Similar to Staphylococcus aureus arsenical pump membrane protein ArsB SW:ARSB_STAAU (P30329) (429 aa) fasta scores: E(): 1.1e-119, 79.953% id in 429 aa, and to Escherichia coli arsenical pump membrane protein ArsB SW:ARSB_ECOLI (P37310) (429 aa) fasta scores: E(): 1.1e-82, 55.556% id in 423 aa. Similar to SAR0691, 79.254% identity (79.254% ungapped) in 429 aa overlap; arsenical pump membrane protein 2 1947792 arsB2 2859865 arsB2 Staphylococcus aureus subsp. aureus MRSA252 arsenical pump membrane protein 2 YP_041242.1 1946500 D 282458 CDS YP_041243.1 49484019 2860347 complement(1947879..1948733) 1 NC_002952.2 Possible gene remnant. C-terminus is similar to C-terminal regions of Staphylococcus aureus bifunctional autolysin precursor [includes: N-acetylmuramoyl-L-alanine amidase; mannosyl-glycoprotein endo-beta-N-acetylglucosamidase] Atl SW:ATL_STAAU (P52081) (1256 aa) fasta scores: E(): 7.5e-30, 42.857% id in 245 aa, and to Staphylococcus saprophyticus surface protein Aas TR:O86919 (EMBL:AJ000007) (1463 aa) fasta scores: E(): 8e-34, 48.163% id in 245 aa; hypothetical protein 1948733 2860347 SAR1857 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041243.1 1947879 R 282458 CDS YP_041244.1 49484020 2860348 complement(1949009..1949233) 1 NC_002952.2 Poor database matches. Similar to C-terminal region of Arabidopsis thaliana floral homeotic protein PI SW:PIST_ARATH (P48007) (208 aa) fasta scores: E(): 3.8, 30.556% id in 72 aa; hypothetical protein 1949233 2860348 SAR1858 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041244.1 1949009 R 282458 CDS YP_041245.1 49484021 2860349 1949432..1949902 1 NC_002952.2 Poor database matches. Similar to Clostridium botulinum phage 1C hypothetical protein Orf22 TR:Q38195 (EMBL:X72793) (179 aa) fasta scores: E(): 0.00077, 27.389% id in 157 aa, and to Escherichia coli probable RNA polymerase sigma factor FecI SW:FECI_ECOLI (P23484) (173 aa) fasta scores: E(): 0.097, 25.610% id in 164 aa; DNA-binding protein 1949902 2860349 SAR1859 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_041245.1 1949432 D 282458 CDS YP_041246.1 49484022 2860350 1950015..1950458 1 NC_002952.2 hypothetical protein 1950458 2860350 SAR1860 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041246.1 1950015 D 282458 CDS YP_041247.1 49484023 2860351 complement(1950445..1950888) 1 NC_002952.2 hypothetical protein 1950888 2860351 SAR1861 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041247.1 1950445 R 282458 CDS YP_041248.1 49484024 2860352 1951186..1951821 1 NC_002952.2 Poor database matches. Similar to Streptococcus pneumoniae ABC transporter ATP binding domain SP0547 TR:Q9EW58 (EMBL:AJ278419) (203 aa) fasta scores: E(): 2.2e-07, 27.778% id in 198 aa. Similar to SAR1863, 52.000% identity (52.000% ungapped) in 200 aa overlap; CAAX amino terminal protease 1951821 2860352 SAR1862 Staphylococcus aureus subsp. aureus MRSA252 CAAX amino terminal protease YP_041248.1 1951186 D 282458 CDS YP_041249.1 49484025 2860353 1951988..1952608 1 NC_002952.2 Poor database matches. Similar to Streptococcus pneumoniae ABC transporter ATP binding domain SP0547 TR:Q9EW58 (EMBL:AJ278419) (203 aa) fasta scores: E(): 3.8e-07, 23.858% id in 197 aa. Similar to SAR1862, 52.000% identity (52.000% ungapped) in 200 aa overlap; hypothetical protein 1952608 2860353 SAR1863 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041249.1 1951988 D 282458 CDS YP_041250.1 49484026 2860354 complement(1953066..1953779) 1 NC_002952.2 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; translaldolase 1953779 2860354 SAR1864 Staphylococcus aureus subsp. aureus MRSA252 translaldolase YP_041250.1 1953066 R 282458 CDS YP_041251.1 49484027 2860355 1954038..1954340 1 NC_002952.2 Poor database matches. Similar to the C-terminal region of Escherichia coli hypothetical protein EscT TR:Q9AJ27 (EMBL:AF200363) (258 aa) fasta scores: E(): 2.3, 33.333% id in 93 aa; hypothetical protein 1954340 2860355 SAR1865 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041251.1 1954038 D 282458 CDS YP_041252.1 49484028 2860356 1954517..1954960 1 NC_002952.2 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1954960 2860356 SAR1866 Staphylococcus aureus subsp. aureus MRSA252 camphor resistance protein CrcB YP_041252.1 1954517 D 282458 CDS YP_041253.1 49484029 2860357 1954957..1955310 1 NC_002952.2 Similar to Escherichia coli camphor resistance and chromosome condensation protein CrcB SW:CRCB_ECOLI (P37002) (127 aa) fasta scores: E(): 6.9e-06, 34.959% id in 123 aa, and to Bacillus halodurans protein CrcB homologue 1 BH2986 TR:Q9K8M0 (EMBL:AP001517) (127 aa) fasta scores: E(): 2.6e-06, 36.800% id in 125 aa; CrcB-like protein 1955310 2860357 SAR1867 Staphylococcus aureus subsp. aureus MRSA252 CrcB-like protein YP_041253.1 1954957 D 282458 CDS YP_041254.1 49484030 2860358 complement(1955560..1956393) 1 NC_002952.2 Similar to Bacillus subtilis morphine dehydrogenase YtbE TR:O34678 (EMBL:AF008220) (280 aa) fasta scores: E(): 8.8e-57, 54.779% id in 272 aa, and to Bacillus subtilis hypothetical protein YvgN TR:O32210 (EMBL:Z99121) (276 aa) fasta scores: E(): 3.7e-56, 56.554% id in 267 aa; aldo/keto reductase 1956393 2860358 SAR1868 Staphylococcus aureus subsp. aureus MRSA252 aldo/keto reductase YP_041254.1 1955560 R 282458 CDS YP_041255.1 49484031 2860359 complement(1956605..1957516) 1 NC_002952.2 Poor database matches. N-terminus is similar to N-terminal region of Physarum polycephalum plasmodial specific LAV1-2 protein SW:LAV1_PHYPO (P14725) (355 aa) fasta scores: E(): 3.2, 25.82% id in 213 aa; hypothetical protein 1957516 2860359 SAR1869 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041255.1 1956605 R 282458 CDS YP_041256.1 49484032 2860360 complement(1957638..1958831) 1 NC_002952.2 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1958831 2860360 SAR1870 Staphylococcus aureus subsp. aureus MRSA252 S-adenosylmethionine synthetase YP_041256.1 1957638 R 282458 CDS YP_041257.1 49484033 2861481 1959203..1960795 1 NC_002952.2 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 1960795 pckA 2861481 pckA Staphylococcus aureus subsp. aureus MRSA252 phosphoenolpyruvate carboxykinase YP_041257.1 1959203 D 282458 CDS YP_041258.1 49484034 2860361 complement(1961088..1961858) 1 NC_002952.2 Similar to Bacillus subtilis peptidase YtmA TR:O34493 (EMBL:AF008220) (257 aa) fasta scores: E(): 2.9e-28, 39.74% id in 239 aa, and to Bacillus halodurans hypothetical protein BH3306 TR:Q9K7Q5 (EMBL:AP001518) (265 aa) fasta scores: E(): 1.4e-23, 37.54% id in 253 aa; hypothetical protein 1961858 2860361 SAR1873 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041258.1 1961088 R 282458 CDS YP_041259.1 49484035 2860542 complement(1961839..1962318) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtkD TR:O35013 (EMBL:AF008220) (158 aa) fasta scores: E(): 1.1e-15, 37.34% id in 158 aa, and to Bacillus halodurans hypothetical protein BH3308 TR:Q9K7Q3 (EMBL:AP001518) (157 aa) fasta scores: E(): 2.3e-12, 36% id in 150 aa; hypothetical protein 1962318 2860542 SAR1874 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041259.1 1961839 R 282458 CDS YP_041260.1 49484036 2860543 1962378..1962635 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtjA SW:YTJA_BACSU (O34601) (75 aa) fasta scores: E(): 2.7e-20, 70.27% id in 74 aa, and to Bacillus halodurans hypothetical protein BH2828 SW:YS28_BACHD (Q9K921) (75 aa) fasta scores: E(): 1.1e-18, 64.86% id in 74 aa; hypothetical protein 1962635 2860543 SAR1875 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041260.1 1962378 D 282458 CDS YP_041261.1 49484037 2860544 complement(1962632..1963633) 1 NC_002952.2 Similar to Amycolatopsis sp N-acylamino acid racemase AaaR TR:Q44244 (EMBL:D30738) (368 aa) fasta scores: E(): 1.8e-09, 24.92% id in 341 aa, and to Thermoplasma acidophilum probable N-acylamino acid racemase TA0249 TR:Q9HLH9 (EMBL:AL445063) (361 aa) fasta scores: E(): 1.4e-10, 25.14% id in 342 aa; hypothetical protein 1963633 2860544 SAR1876 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041261.1 1962632 R 282458 CDS YP_041262.1 49484038 2860545 complement(1963638..1965116) 1 NC_002952.2 Similar to Bacillus subtilis O-succinylbenzoic CoA synthase MenE TR:O34837 (EMBL:AF008220) (486 aa) fasta scores: E(): 9.5e-47, 32.86% id in 496 aa, and to Lactococcus lactis O-succinylbenzoic acid-CoA ligase MenE TR:Q9CHK3 (EMBL:AE006306) (420 aa) fasta scores: E(): 4.9e-34, 35.26% id in 448 aa; AMP-binding protein 1965116 2860545 SAR1877 Staphylococcus aureus subsp. aureus MRSA252 AMP-binding protein YP_041262.1 1963638 R 282458 CDS YP_041263.1 49484039 2860546 complement(1965275..1965757) 1 NC_002952.2 lipoprotein 1965757 2860546 SAR1878 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_041263.1 1965275 R 282458 CDS YP_041264.1 49484040 2860547 1966128..1966682 1 NC_002952.2 No significant database matches. Possible alternative translational start sites; hypothetical protein 1966682 2860547 SAR1879 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041264.1 1966128 D 282458 CDS YP_041265.1 49484041 2860548 1966763..1967758 1 NC_002952.2 Internal region is similar to N-terminus of Bacillus halodurans hypothetical protein BH3064 TR:Q9K8E2 (EMBL:AP001517) (215 aa) fasta scores: E(): 7.7e-10, 37.58% id in 141 aa; hypothetical protein 1967758 2860548 SAR1880 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041265.1 1966763 D 282458 CDS YP_041266.1 49484042 2860549 1967834..1968460 1 NC_002952.2 lipoprotein 1968460 2860549 SAR1881 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_041266.1 1967834 D 282458 CDS YP_041267.1 49484043 2860550 1968501..1968845 1 NC_002952.2 Poor database matches. Similar to Chrysodidymus synuroideus ribosomal protein S10 Rps10 TR:Q9MGA1 (EMBL:AF222718) (103 aa) fasta scores: E(): 9.2, 26.66% id in 90 aa; hypothetical protein 1968845 2860550 SAR1882 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041267.1 1968501 D 282458 CDS YP_041268.1 49484044 2860551 1968943..1969515 1 NC_002952.2 Poor database matches. Similar to N-terminal region of Mycoplasma pulmonis hypothetical protein MYPU_3700 TR:CAC13543 (EMBL:AL445564) (292 aa) fasta scores: E(): 3.5e-08, 37.25% id in 153 aa. Possible gene remnant; hypothetical protein 1969515 2860551 SAR1883 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041268.1 1968943 D 282458 CDS YP_041269.1 49484045 2860552 complement(1969664..1971031) 1 NC_002952.2 C-terminus is similar to an internal region of Bacillus anthracis virulence plasmid pX01 hypothetical protein pX01-90 TR:Q9X360 (EMBL:AF065404) (652 aa) fasta scores: E(): 0.017, 29.9% id in 214 aa; hypothetical protein 1971031 2860552 SAR1884 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041269.1 1969664 R 282458 CDS YP_041270.1 49484046 2860553 complement(1971031..1971600) 1 NC_002952.2 Poor database matches. Similar to N-terminal region of Borrelia burgdorferi hypothetical protein BBB26 TR:O50997 (EMBL:AE000792) (231 aa) fasta scores: E(): 1.4e-05, 31.05% id in 161 aa. N-terminus is similar to the N-terminal region of Bacillus subtilis phage-like element PBSX protein XkdA SW:XKDA_BACSU (P39780) (198 aa) fasta scores: E(): 0.41, 25.64% id in 117 aa; hypothetical protein 1971600 2860553 SAR1885 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041270.1 1971031 R 282458 CDS YP_041271.1 49484047 2860554 complement(1971793..1972239) 1 NC_002952.2 No significant database matches. Similar to SAR1889, 65.541% identity (65.986% ungapped) in 148 aa overlap, SAR1894, 59.864% identity (60.274% ungapped) in 147 aa overlap, an to SAR1890, 56.081% identity (56.463% ungapped) in 148 aa overlap. C-terminal region is similar to SAR1891, 68.224% identity (68.868% ungapped) in 107 aa overlap; hypothetical protein 1972239 2860554 SAR1886 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041271.1 1971793 R 282458 CDS YP_041272.1 49484048 2859311 complement(1973184..1973630) 1 NC_002952.2 No significant database matches. Similar to SAR1886, 65.541% identity (65.986% ungapped) in 148 aa overlap, SAR1890, 62.838% identity (62.838% ungapped) in 148 aa overlap, SAR1894, 55.405% identity (55.405% ungapped) in 148 aa overlap, and to SAR1891, 62.264% identity (62.264% ungapped) in 106 aa overlap; hypothetical protein 1973630 2859311 SAR1889 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041272.1 1973184 R 282458 CDS YP_041273.1 49484049 2859312 complement(1973627..1974073) 1 NC_002952.2 No significant database matches. Similar to SAR1889, 62.838% identity (62.838% ungapped) in 148 aa overlap, SAR1886, 56.081% identity (56.463% ungapped) in 148 aa overlap, SAR1894, 55.034% identity (55.405% ungapped) in 149 aa overlap, and to SAR1891, 61.321% identity (61.321% ungapped) in 106 aa overlap; hypothetical protein 1974073 2859312 SAR1890 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041273.1 1973627 R 282458 CDS YP_041274.1 49484050 2859653 1975037..1977457 1 NC_002952.2 Similar to Staphylococcus aureus hyaluronate lyase precursor HysA SW:HYSA_STAAU (Q59801) (807 aa) fasta scores: E(): 0, 75.8% id in 810 aa, and to Streptococcus pneumoniae hyaluronate lyase precursor SP0314 SW:HYSA_STRPN (Q54873) (949 aa) fasta scores: E(): 6.5e-74, 35.34% id in 795 aa. Similar to SAR2292, 74.969% identity (75.716% ungapped) in 811 aa overlap; hyaluronate lyase precursor 1 1977457 hysA1 2859653 hysA1 Staphylococcus aureus subsp. aureus MRSA252 hyaluronate lyase precursor 1 YP_041274.1 1975037 D 282458 CDS YP_041275.1 49484051 2859314 complement(1977583..1977960) 1 NC_002952.2 No significant database matches. Possible alternative translational start sites; hypothetical protein 1977960 2859314 SAR1893 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041275.1 1977583 R 282458 CDS YP_041276.1 49484052 2859315 complement(1978170..1978619) 1 NC_002952.2 No significant database matches. Similar to SAR1891, 90.566% identity (90.566% ungapped) in 106 aa overlap, SAR1886, 59.864% identity (60.274% ungapped) in 147 aa overlap, SAR1889, 55.405% identity (55.405% ungapped) in 148 aa overlap, and to SAR1890, 55.034% identity (55.405% ungapped) in 149 aa overlap. Similar to SAR1891, 90.566% identity (90.566% ungapped) in 106 aa overlap, SAR1886, 59.864% identity (60.274% ungapped) in 147 aa overlap, SAR1889, 55.405% identity (55.405% ungapped) in 148 aa overlap, and to SAR1890, 55.034% identity (55.405% ungapped) in 149 aa overlap; hypothetical protein 1978619 2859315 SAR1894 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041276.1 1978170 R 282458 CDS YP_041277.1 49484053 2859316 1978662..1980272 1 NC_002952.2 Poor database matches. Similar to internal region of Clostridium botulinum botulinum neurotoxin type C1 precursor SW:BXC1_CLOBO (P18640) (1290 aa) fasta scores: E(): 0.41, 20.46% id in 557 aa; hypothetical protein 1980272 2859316 SAR1895 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041277.1 1978662 D 282458 CDS YP_041278.1 49484054 2859317 1980287..1980586 1 NC_002952.2 Poor database matches. Similar to internal region of Campylobacter jejuni periplasmic protein CJ0162C TR:Q9PIW5 (EMBL:AL139074) (171 aa) fasta scores: E(): 1, 29.16% id in 96 aa; hypothetical protein 1980586 2859317 SAR1896 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041278.1 1980287 D 282458 CDS YP_041279.1 49484055 2859318 complement(1980848..1982665) 1 NC_002952.2 Poor database matches. Similar to N-terminal region of Synechocystis sp hypothetical protein SLR1135 TR:P73259 (EMBL:D90905) (715 aa) fasta scores: E(): 4.7e-05, 24.76% id in 626 aa; hypothetical protein 1982665 2859318 SAR1897 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041279.1 1980848 R 282458 CDS YP_041280.1 49484056 2859319 complement(1982702..1983856) 1 NC_002952.2 Similar to Streptococcus thermophilus type I restriction modification S-subunit protein TR:O52188 (EMBL:AF027167) (412 aa) fasta scores: E(): 3.1e-26, 32.54% id in 421 aa, and to Lactococcus lactis plasmid pSRQ900 type I restriction modification specificity subunit protein HsdS TR:AAC98712 (EMBL:AF001314) (396 aa) fasta scores: E(): 2.1e-20, 27.88% id in 416 aa; type I restriction modification DNA specificity protein 1983856 2859319 SAR1898 Staphylococcus aureus subsp. aureus MRSA252 type I restriction modification DNA specificity protein YP_041280.1 1982702 R 282458 CDS YP_041281.1 49484057 2859320 complement(1983849..1985405) 1 NC_002952.2 Similar to Escherichia coli type I restriction enzyme EcoR124II M protein HsdM SW:T1M1_ECOLI (P10484) (520 aa) fasta scores: E(): 6.4e-73, 42.18% id in 512 aa, and to Streptococcus thermophilus type IC modification subunit HsdM TR:Q9RNW1 (EMBL:AF177167) (531 aa) fasta scores: E(): 2.4e-84, 49.13% id in 517 aa. Similar to SAR0433, 98.456% identity (98.456% ungapped) in 518 aa overlap; type I restriction modification system modification protein 1985405 2859320 SAR1899 Staphylococcus aureus subsp. aureus MRSA252 type I restriction modification system modification protein YP_041281.1 1983849 R 282458 CDS YP_041282.1 49484058 2859156 complement(1986657..1987373) 1 NC_002952.2 Similar to Staphylococcus aureus serine protease SplE TR:Q9KH47 (EMBL:AF271715) (238 aa) fasta scores: E(): 1.9e-85, 97.05% id in 238 aa. Simlar to SAR1905, 63.445% identity (63.445% ungapped) in 238 aa overlap, SAR1900, 64.481% identity (64.835% ungapped) in 183 aa overlap, and to SAR1903, 56.757% identity (56.757% ungapped) in 74 aa overlap; serine protease 1987373 splE 2859156 splE Staphylococcus aureus subsp. aureus MRSA252 serine protease YP_041282.1 1986657 R 282458 CDS YP_041283.1 49484059 2859322 complement(1988419..1989135) 1 NC_002952.2 Similar to Staphylococcus aureus serine protease SplE TR:Q9KH47 (EMBL:AF271715) (238 aa) fasta scores: E(): 3.9e-56, 62.6% id in 238 aa. Similar to SAR1902, 63.445% identity (63.445% ungapped) in 238 aa overlap; serine protease 1989135 2859322 SAR1905 Staphylococcus aureus subsp. aureus MRSA252 serine protease YP_041283.1 1988419 R 282458 CDS YP_041284.1 49484060 2859155 complement(1989259..1989978) 1 NC_002952.2 Similar to Staphylococcus aureus serine protease SplC TR:Q9KH49 (EMBL:AF271715) (239 aa) fasta scores: E(): 7.6e-83, 94.56% id in 239 aa; serine protease 1989978 splC 2859155 splC Staphylococcus aureus subsp. aureus MRSA252 serine protease YP_041284.1 1989259 R 282458 CDS YP_041285.1 49484061 2859324 1990279..1990524 1 NC_002952.2 hypothetical protein 1990524 2859324 SAR1908 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041285.1 1990279 D 282458 CDS YP_041286.1 49484062 2859325 1990763..1990894 1 NC_002952.2 hypothetical protein 1990894 2859325 SAR1909 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041286.1 1990763 D 282458 CDS YP_041287.1 49484063 2859326 1990993..1991508 1 NC_002952.2 hypothetical protein 1991508 2859326 SAR1910 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041287.1 1990993 D 282458 CDS YP_041288.1 49484064 2859327 1991755..1993101 1 NC_002952.2 Poor database matches. C-terminus is similar to the C-terminal region of bacteriophage P27 hypothetical protein TR:Q9MC01 (EMBL:AJ249351) (409 aa) fasta scores: E(): 8.6e-21, 32.19% id in 323 aa. Contains coiled-coiled domains, residues 66 to 90, 248 to 278, 299 to 318; hypothetical protein 1993101 2859327 SAR1911 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041288.1 1991755 D 282458 CDS YP_041289.1 49484065 2859329 1993688..1993924 1 NC_002952.2 hypothetical protein 1993924 2859329 SAR1913 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041289.1 1993688 D 282458 CDS YP_041290.1 49484066 2859331 complement(1995296..1996072) 1 NC_002952.2 Similar to Staphylococcus aureus extracellular enterotoxin type G precursor Seg TR:O85382 (EMBL:AF064773) (258 aa) fasta scores: E(): 4.5e-101, 97.28% id in 258 aa, and to Staphylococcus aureus enterotoxin type B precursor EntB SW:ETXB_STAAU (P01552) (266 aa) fasta scores: E(): 8.1e-35, 44.65% id in 262 aa; enterotoxin 1996072 2859331 SAR1916 Staphylococcus aureus subsp. aureus MRSA252 enterotoxin YP_041290.1 1995296 R 282458 CDS YP_041291.1 49484067 2859332 complement(1996356..1997111) 1 NC_002952.2 Similar to Staphylococcus aureus enterotoxin SEN TR:Q9EZM4 (EMBL:AF285760) (258 aa) fasta scores: E(): 8.3e-90, 95.21% id in 251 aa, and to Staphylococcus aureus enterotoxin type A precursor EntA SW:ETXA_STAAU (P13163) (257 aa) fasta scores: E(): 8.8e-30, 37.84% id in 251 aa. CDS is truncated at the N-terminus in comparison to orthologues; enterotoxin 1997111 2859332 SAR1917 Staphylococcus aureus subsp. aureus MRSA252 enterotoxin YP_041291.1 1996356 R 282458 CDS YP_041292.1 49484068 2859333 complement(1997150..1997935) 1 NC_002952.2 Similar to Staphylococcus aureus enterotoxin type B precursor EntB SW:ETXB_STAAU (P01552) (266 aa) fasta scores: E(): 4.6e-51, 54.23% id in 260 aa, and to Staphylococcus aureus enterotoxin type C-3 precursor EntC3 SW:ETC3_STAAU (P23313) (266 aa) fasta scores: E(): 1.2e-50, 52.3% id in 260 aa; enterotoxin 1997935 2859333 SAR1918 Staphylococcus aureus subsp. aureus MRSA252 enterotoxin YP_041292.1 1997150 R 282458 CDS YP_041293.1 49484069 2859334 complement(1998089..1998817) 1 NC_002952.2 Similar to Staphylococcus aureus extracellular enterotoxin type I precursor SEI TR:O85383 (EMBL:AF064774) (242 aa) fasta scores: E(): 1.2e-91, 95.86% id in 242 aa, and to Staphylococcus aureus enterotoxin Ent TR:O54476 (EMBL:U93688) (242 aa) fasta scores: E(): 8.6e-64, 67.35% id in 242 aa. Similar to SAR1920, 56.017% identity (57.203% ungapped) in 241 aa overlap; enterotoxin 1998817 2859334 SAR1919 Staphylococcus aureus subsp. aureus MRSA252 enterotoxin YP_041293.1 1998089 R 282458 CDS YP_041294.1 49484070 2859335 complement(1998852..1999571) 1 NC_002952.2 Similar to Staphylococcus aureus enterotoxin SEM TR:Q9EZM7 (EMBL:AF285760) (239 aa) fasta scores: E(): 1.1e-83, 92.05% id in 239 aa, and to Staphylococcus aureus, and extracellular enterotoxin type I precursor SEI TR:O85383 (EMBL:AF064774) (242 aa) fasta scores: E(): 5.6e-49, 57.08% id in 233 aa. Similar to SAR1919, 56.017% identity (57.203% ungapped) in 241 aa overlap; enterotoxin 1999571 2859335 SAR1920 Staphylococcus aureus subsp. aureus MRSA252 enterotoxin YP_041294.1 1998852 R 282458 CDS YP_041295.1 49484071 2859336 complement(1999853..2000617) 1 NC_002952.2 Similar to Staphylococcus aureus enterotoxin SEL TR:Q9EZM8 (EMBL:AF285760) (261 aa) fasta scores: E(): 1.1e-87, 90.55% id in 254 aa, and to Staphylococcus aureus enterotoxin SEK TR:Q9EZM4 (EMBL:AF285760) (258 aa) fasta scores: E(): 1.3e-38, 43.87% id in 253 aa; enterotoxin 2000617 2859336 SAR1921 Staphylococcus aureus subsp. aureus MRSA252 enterotoxin YP_041295.1 1999853 R 282458 CDS YP_041296.1 49484072 2859337 complement(2002078..2002632) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdeN TR:P96671 (EMBL:AB001488) (190 aa) fasta scores: E(): 3.2e-13, 24.04% id in 183 aa, and to Homo sapiens retinoblastoma-binding protein Bog TR:Q9H1D8 (EMBL:AF039564) (186 aa) fasta scores: E(): 0.00069, 21.22% id in 179 aa; hypothetical protein 2002632 2859337 SAR1922 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041296.1 2002078 R 282458 CDS YP_041297.1 49484073 2860707 complement(2002952..2004352) 1 NC_002952.2 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 2004352 hemY 2860707 hemY Staphylococcus aureus subsp. aureus MRSA252 protoporphyrinogen oxidase YP_041297.1 2002952 R 282458 CDS YP_041298.1 49484074 2860705 complement(2004376..2005299) 1 NC_002952.2 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 2005299 hemH 2860705 hemH Staphylococcus aureus subsp. aureus MRSA252 ferrochelatase YP_041298.1 2004376 R 282458 CDS YP_041299.1 49484075 2860704 complement(2005357..2006394) 1 NC_002952.2 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 2006394 hemE 2860704 hemE Staphylococcus aureus subsp. aureus MRSA252 uroporphyrinogen decarboxylase YP_041299.1 2005357 R 282458 CDS YP_041300.1 49484076 2860395 2006656..2007159 1 NC_002952.2 Similar to Staphylococcus aureus signal transduction protein, target of RNAIII-activating protein, TRAP TR:Q9F949 (EMBL:AF202641) (167 aa) fasta scores: E(): 8.2e-60, 88.02% id in 167 aa, and to Bacillus subtilis hypothetical protein YhgC SW:YHGC_BACSU (P38049) (166 aa) fasta scores: E(): 1e-08, 26.54% id in 162 aa; signal transduction protein 2007159 trap 2860395 trap Staphylococcus aureus subsp. aureus MRSA252 signal transduction protein YP_041300.1 2006656 D 282458 CDS YP_041301.1 49484077 2859338 complement(2007283..2008506) 1 NC_002952.2 Similar to Bacillus subtilis novel ABC transporter EcsB SW:ECSB_BACSU (P55340) (408 aa) fasta scores: E(): 4e-26, 27.97% id in 404 aa, and to Bacillus halodurans ABC transporter BH1192 TR:Q9KDM0 (EMBL:AP001511) (405 aa) fasta scores: E(): 1.7e-21, 24.48% id in 388 aa; transporter protein 2008506 2859338 SAR1927 Staphylococcus aureus subsp. aureus MRSA252 transporter protein YP_041301.1 2007283 R 282458 CDS YP_041302.1 49484078 2859339 complement(2008499..2009239) 1 NC_002952.2 Similar to Bacillus subtilis ABC-type transporter ATP-binding protein EcsA SW:ECSA_BACSU (P55339) (247 aa) fasta scores: E(): 7.8e-49, 58.82% id in 238 aa, and to Lactococcus lactis ABC transporter ATP binding protein EcsA TR:Q9CE51 (EMBL:AE006429) (256 aa) fasta scores: E(): 7.3e-51, 59.83% id in 239 aa; ABC transporter ATP-binding protein 2009239 2859339 SAR1928 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041302.1 2008499 R 282458 CDS YP_041303.1 49484079 2859340 2009373..2009795 1 NC_002952.2 Similar to Schizosaccharomyces pombe hypothetical HIT-family protein SPCC1442.14C TR:O94586 (EMBL:AL031966) (133 aa) fasta scores: E(): 5.7e-13, 37.03% id in 135 aa, and to Bacillus halodurans HIT-like protein involved in cell-cycle regulation BH1189 TR:Q9KDM3 (EMBL:AP001511) (142 aa) fasta scores: E(): 9.8e-25, 53.67% id in 136 aa; HIT-family protein 2009795 2859340 SAR1929 Staphylococcus aureus subsp. aureus MRSA252 HIT-family protein YP_041303.1 2009373 D 282458 CDS YP_041304.1 49484080 2859341 2009937..2010302 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans hypothetical protein BH1186 TR:Q9KDM6 (EMBL:AP001511) (114 aa) fasta scores: E(): 0.18, 31.06% id in 103 aa; hypothetical protein 2010302 2859341 SAR1930 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041304.1 2009937 D 282458 CDS YP_041305.1 49484081 2859342 <2010299..2010487 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 2010487 2859342 SAR1930a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041305.1 <2010299 D 282458 CDS YP_041306.1 49484082 2859343 2011035..2011592 1 NC_002952.2 oor database matches. Similar to Bacillus halodurans hypothetical protein BH1182 TR:Q9KDM9 (EMBL:AP001511) (180 aa) fasta scores: E(): 4.4e-09, 26.85% id in 175 aa; hypothetical protein 2011592 2859343 SAR1931 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041306.1 2011035 D 282458 CDS YP_041307.1 49484083 2859344 2011797..2012759 1 NC_002952.2 Similar to Bacillus subtilis protein export protein PrsA SW:PRSA_BACSU (P24327) (292 aa) fasta scores: E(): 1.8e-10, 35.43% id in 302 aa, and to Bacillus halodurans protein export protein BH1177 TR:Q9KDN4 (EMBL:AP001511) (333 aa) fasta scores: E(): 1.5e-08, 25.24% id in 301 aa; peptidyl-prolyl cis-isomerase 2012759 2859344 SAR1932 Staphylococcus aureus subsp. aureus MRSA252 peptidyl-prolyl cis-isomerase YP_041307.1 2011797 D 282458 CDS YP_041308.1 49484084 2859345 complement(2012880..2013821) 1 NC_002952.2 catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates; 3'-5' exoribonuclease YhaM 2013821 2859345 SAR1933 Staphylococcus aureus subsp. aureus MRSA252 3'-5' exoribonuclease YhaM YP_041308.1 2012880 R 282458 CDS YP_041309.1 49484085 2859346 complement(2013818..2016754) 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YhaN TR:O08455 (EMBL:Y14078) (963 aa) fasta scores: E(): 2.7e-17, 24.42% id in 991 aa; hypothetical protein 2016754 2859346 SAR1934 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041309.1 2013818 R 282458 CDS YP_041310.1 49484086 2859347 complement(2016744..2017940) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhaO TR:O07522 (EMBL:Y14078) (408 aa) fasta scores: E(): 1.1e-38, 34.91% id in 401 aa, and to Methanococcus jannaschii hypothetical protein MJ1323 mj1323 TR:Q58719 (EMBL:U67572) (366 aa) fasta scores: E(): 1e-08, 24.67% id in 385 aa; DNA repair exonuclease 2017940 2859347 SAR1935 Staphylococcus aureus subsp. aureus MRSA252 DNA repair exonuclease YP_041310.1 2016744 R 282458 CDS YP_041311.1 49484087 2859348 complement(2018828..2019172) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YheA TR:O07542 (EMBL:Y14080) (117 aa) fasta scores: E(): 1.1e-13, 49.1% id in 112 aa, and to Bacillus firmus hypothetical protein TR:O87558 (EMBL:AF084104) (118 aa) fasta scores: E(): 1e-12, 46.84% id in 111 aa; hypothetical protein 2019172 2859348 SAR1936 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041311.1 2018828 R 282458 CDS YP_041312.1 49484088 2861182 complement(2019241..2020365) 1 NC_002952.2 Similar to Bacillus firmus hypothetical protein TR:O87557 (EMBL:AF084104) (370 aa) fasta scores: E(): 6.8e-32, 31.09% id in 373 aa, and to Bacillus subtilis hypothetical protein YheB TR:O07543 (EMBL:Y14080) (377 aa) fasta scores: E(): 2.7e-31, 30.35% id in 369 aa; hypothetical protein 2020365 2861182 SAR1937 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041312.1 2019241 R 282458 CDS YP_041313.1 49484089 2861183 complement(2020544..2021008) 1 NC_002952.2 No significant database matches to the full length CDS. N-terminal region is similar to Streptococcus pneumoniae transcription regulator SP0333 TR:P72494 (EMBL:Z79691) (64 aa) fasta scores: E(): 2.3, 30.5% id in 59 aa, and Streptococcus pyogenes transcription regulator SPY1934 TR:Q99Y06 (EMBL:AE006617) (68 aa) fasta scores: E(): 0.97, 28.81% id in 59 aa; DNA-binding protein 2021008 2861183 SAR1938 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_041313.1 2020544 R 282458 CDS YP_041314.1 49484090 2861184 complement(2021366..2021989) 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Similar to Bacillus halodurans two-component response regulator BH2213 TR:Q9KAS4 (EMBL:AP001514) (217 aa) fasta scores: E(): 1.6e-28, 47.08% id in 206 aa, and to Bacillus subtilis hypothetical protein YhcZ TR:O07528 (EMBL:Y14079) (214 aa) fasta scores: E(): 6.6e-27, 44.49% id in 209 aa; response regulator 2021989 2861184 SAR1939 Staphylococcus aureus subsp. aureus MRSA252 response regulator YP_041314.1 2021366 R 282458 CDS YP_041315.1 49484091 2861185 complement(2022011..2023123) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhcY TR:O07527 (EMBL:Y14079) (379 aa) fasta scores: E(): 2.4e-47, 40% id in 365 aa, and to the Bacillus halodurans two-component sensor histidine kinase BH2214 TR:Q9KAS3 (EMBL:AP001514) (478 aa) fasta scores: E(): 2.3e-18, 28.72% id in 470 aa. B. halodurans protein is larger in comparison to the CDS and contains extra internal amino acids.; histidine kinase 2023123 2861185 SAR1940 Staphylococcus aureus subsp. aureus MRSA252 histidine kinase YP_041315.1 2022011 R 282458 CDS YP_041316.1 49484092 2861186 2023286..2024107 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhcT SW:YHCT_BACSU (P54604) (302 aa) fasta scores: E(): 3.5e-29, 39.6% id in 255 aa, and to Lactococcus lactis possible pseudouridine synthase RluA TR:Q9CDU9 (EMBL:AE006439) (288 aa) fasta scores: E(): 3.9e-29, 38.18% id in 275 aa; RNA pseudouridylate synthase 2024107 2861186 SAR1941 Staphylococcus aureus subsp. aureus MRSA252 RNA pseudouridylate synthase YP_041316.1 2023286 D 282458 CDS YP_041317.1 49484093 2861359 complement(2024563..2025948) 1 NC_002952.2 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 2025948 fumC 2861359 fumC Staphylococcus aureus subsp. aureus MRSA252 fumarate hydratase YP_041317.1 2024563 R 282458 CDS YP_041318.1 49484094 2861187 complement(2026144..2026539) 1 NC_002952.2 hypothetical protein 2026539 2861187 SAR1943 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041318.1 2026144 R 282458 CDS YP_041319.1 49484095 2861188 complement(2027140..2027292) 1 NC_002952.2 hypothetical protein 2027292 2861188 SAR1944 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041319.1 2027140 R 282458 CDS YP_041320.1 49484096 2861189 complement(2027317..2027916) 1 NC_002952.2 hypothetical protein 2027916 2861189 SAR1945 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041320.1 2027317 R 282458 CDS YP_041321.1 49484097 2861190 complement(2028075..2028545) 1 NC_002952.2 Similar to Bacillus subtilis methylase homologue CspR TR:Q45512 (EMBL:U58864) (157 aa) fasta scores: E(): 3.5e-42, 64.74% id in 156 aa, and to Bacillus stearothermophilus hypothetical protein SW:YGL3_BACST (P32813) (157 aa) fasta scores: E(): 5.5e-42, 66.24% id in 157 aa; SpoU rRNA methylase 2028545 2861190 SAR1946 Staphylococcus aureus subsp. aureus MRSA252 SpoU rRNA methylase YP_041321.1 2028075 R 282458 CDS YP_041322.1 49484098 2861191 complement(2028550..2029677) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1020 TR:Q9KE38 (EMBL:AP001510) (391 aa) fasta scores: E(): 6.5e-86, 57.45% id in 369 aa, and to Streptococcus pyogenes hypothetical protein SPY0642 TR:Q9A0S6 (EMBL:AE006518) (391 aa) fasta scores: E(): 3.6e-57, 42.81% id in 369 aa; iron-sulfur protein 2029677 2861191 SAR1947 Staphylococcus aureus subsp. aureus MRSA252 iron-sulfur protein YP_041322.1 2028550 R 282458 CDS YP_041323.1 49484099 2859922 complement(2029828..2030556) 1 NC_002952.2 Similar to Bacillus stearothermophilus glutamine transport ATP-binding protein GlnQ SW:GLNQ_BACST (P27675) (242 aa) fasta scores: E(): 7e-43, 55.83% id in 240 aa, and to Streptococcus pyogenes amino acid ABC transporter SPY1506 TR:Q99YW9 (EMBL:AE006584) (244 aa) fasta scores: E(): 8.5e-49, 65% id in 240 aa. Similar to SAR2502, 54.622% identity (55.319% ungapped) in 238 aa overlap; glutamine transport ATP-binding protein 2030556 glnQ 2859922 glnQ Staphylococcus aureus subsp. aureus MRSA252 glutamine transport ATP-binding protein YP_041323.1 2029828 R 282458 CDS YP_041324.1 49484100 2861192 complement(2030543..2032000) 1 NC_002952.2 Similar to Streptococcus pyogenes glutamine-binding periplasmic protein SPY0277 TR:Q9A1H0 (EMBL:AE006494) (522 aa) fasta scores: E(): 1.8e-23, 32.61% id in 512 aa, and to Synechocystis sp glutamine-binding periplasmic protein SLL1270 TR:P73544 (EMBL:D90907) (530 aa) fasta scores: E(): 3e-23, 30.3% id in 518 aa. Possible alternative translational start sites; extracellular glutamine-binding protein 2032000 2861192 SAR1949 Staphylococcus aureus subsp. aureus MRSA252 extracellular glutamine-binding protein YP_041324.1 2030543 R 282458 CDS YP_041325.1 49484101 2861193 complement(2032259..2033320) 1 NC_002952.2 Similar to Treponema pallidum regulatory protein TP0038 TR:Q56343 (EMBL:AE001189) (350 aa) fasta scores: E(): 1.3e-45, 39.82% id in 344 aa, and to Streptococcus pyogenes probable regulatory protein SPY0851 TR:Q9A0B4 (EMBL:AE006535) (352 aa) fasta scores: E(): 5e-40, 39.65% id in 353 aa; hypothetical protein 2033320 2861193 SAR1950 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041325.1 2032259 R 282458 CDS YP_041326.1 49484102 2859896 complement(2042134..2042580) 1 NC_002952.2 Similar to Bacillus subtilis peroxide operon regulator PerR SW:PERR_BACSU (P71086) (145 aa) fasta scores: E(): 2.4e-37, 67.62% id in 139 aa, and to Bacillus halodurans transcriptional regulator BH0951 TR:Q9JWQ8 (EMBL:AP001510) (145 aa) fasta scores: E(): 9.7e-36, 67.62% id in 139 aa; peroxide operon regulator 2042580 perR 2859896 perR Staphylococcus aureus subsp. aureus MRSA252 peroxide operon regulator YP_041326.1 2042134 R 282458 CDS YP_041327.1 49484103 2861194 complement(2042677..2043627) 1 NC_002952.2 Similar to Bacillus halodurans D-3-phosphoglycerate dehydrogenase BH0949 TR:Q9KEA4 (EMBL:AP001510) (316 aa) fasta scores: E(): 7.6e-38, 36.59% id in 317 aa, and to Lactococcus lactis dehydrogenase YugC TR:Q9CE59 (EMBL:AE006429) (325 aa) fasta scores: E(): 2.6e-23, 31.15% id in 321 aa; hypothetical protein 2043627 2861194 SAR1952 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041327.1 2042677 R 282458 CDS YP_041328.1 49484104 2861195 complement(2043633..2044085) 1 NC_002952.2 Similar to Bacillus halodurans bacterioferritin comigratory protein BH0948 TR:Q9KEA5 (EMBL:AP001510) (154 aa) fasta scores: E(): 6.5e-24, 49.3% id in 144 aa, and to Aquifex aeolicus hypothetical protein AQ_495 TR:O66785 (EMBL:AE000692) (161 aa) fasta scores: E(): 6.6e-23, 47.71% id in 153 aa; AhpC/TSA family protein 2044085 2861195 SAR1953 Staphylococcus aureus subsp. aureus MRSA252 AhpC/TSA family protein YP_041328.1 2043633 R 282458 CDS YP_041329.1 49484105 2861196 2044169..2045458 1 NC_002952.2 converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate; glutamate-1-semialdehyde aminotransferase 2045458 2861196 SAR1954 Staphylococcus aureus subsp. aureus MRSA252 glutamate-1-semialdehyde aminotransferase YP_041329.1 2044169 D 282458 CDS YP_041330.1 49484106 2861197 2045751..2046845 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YgaE TR:P71083 (EMBL:Z82044) (353 aa) fasta scores: E(): 1.9e-38, 38.01% id in 363 aa, and to Bacillus halodurans hypothetical protein BH0942 TR:Q9KEB1 (EMBL:AP001510) (360 aa) fasta scores: E(): 2.1e-34, 33.6% id in 363 aa; hypothetical protein 2046845 2861197 SAR1955 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041330.1 2045751 D 282458 CDS YP_041331.1 49484107 2861198 complement(2047036..2048772) 1 NC_002952.2 Similar to Bacillus halodurans ABC transporter BH0941 TR:Q9KEB2 (EMBL:AP001510) (584 aa) fasta scores: E(): 1.8e-132, 64.12% id in 577 aa, and to Bacillus subtilis ABC transporter ATP-binding protein YgaD TR:P71082 (EMBL:Z82044) (589 aa) fasta scores: E(): 3.6e-130, 61.24% id in 578 aa; ABC transporter ATP-binding protein 2048772 2861198 SAR1956 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041331.1 2047036 R 282458 CDS YP_041332.1 49484108 2861199 complement(2049063..2049605) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0940 TR:Q9KEB3 (EMBL:AP001510) (175 aa) fasta scores: E(): 1.3e-44, 63.79% id in 174 aa, and to Lactococcus lactis hypothetical protein YjjG TR:Q9CGX3 (EMBL:AE006331) (176 aa) fasta scores: E(): 3.8e-44, 59.19% id in 174 aa; hypothetical protein 2049605 2861199 SAR1957 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041332.1 2049063 R 282458 CDS YP_041333.1 49484109 2861200 complement(2049908..2050945) 1 NC_002952.2 Similar to Salmonella typhimurium A/G-specific adenine glycosylase MutY SW:MUTY_SALTY (Q05869) (350 aa) fasta scores: E(): 1.1e-34, 33.72% id in 344 aa, and to Bacillus subtilis hypothetical protein YfhQ TR:O31584 (EMBL:Z99108) (369 aa) fasta scores: E(): 1.5e-53, 44.98% id in 349 aa; HhH-GPD superfamily base excision DNA repair protein 2050945 2861200 SAR1958 Staphylococcus aureus subsp. aureus MRSA252 HhH-GPD superfamily base excision DNA repair protein YP_041333.1 2049908 R 282458 CDS YP_041334.1 49484110 2861201 2051097..2052074 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfhP TR:O31583 (EMBL:Z99108) (327 aa) fasta scores: E(): 1.1e-52, 42.76% id in 325 aa, and to Bacillus halodurans hypothetical protein BH0929 TR:Q9KEC4 (EMBL:AP001510) (327 aa) fasta scores: E(): 1.5e-50, 43.29% id in 328 aa; hypothetical protein 2052074 2861201 SAR1959 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041334.1 2051097 D 282458 CDS YP_041335.1 49484111 2861202 complement(2052335..2053171) 1 NC_002952.2 Similar to Bacillus subtilis teichoic acid translocation permease TagG SW:TAGG_BACSU (P42953) (275 aa) fasta scores: E(): 0.00014, 24.61% id in 195 aa, and to Archaeoglobus fulgidus polysaccharide ABC transporter permease AF0289 TR:O29952 (EMBL:AE001085) (252 aa) fasta scores: E(): 0.12, 22.3% id in 260 aa; hypothetical protein 2053171 2861202 SAR1960 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041335.1 2052335 R 282458 CDS YP_041336.1 49484112 2861203 complement(2053180..2054697) 1 NC_002952.2 Similar to Bacillus subtilis teichoic acid translocation ATP-binding protein TagH SW:TAGH_BACSU (P42954) (527 aa) fasta scores: E(): 2.4e-12, 24.04% id in 445 aa, and to Lactococcus lactis teichoic acid ABC transporter ATP binding protein TagH TR:Q9CH26 (EMBL:AE006326) (466 aa) fasta scores: E(): 1.4e-07, 22.22% id in 396 aa; hypothetical protein 2054697 2861203 SAR1961 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041336.1 2053180 R 282458 CDS YP_041337.1 49484113 2861204 complement(2054712..2055026) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfhH TR:O31576 (EMBL:Z99108) (104 aa) fasta scores: E(): 2.5e-11, 40.59% id in 101 aa, and to Bacillus halodurans hypothetical protein BH0925 TR:Q9KEC8 (EMBL:AP001510) (108 aa) fasta scores: E(): 1.4e-10, 42.15% id in 102 aa; hypothetical protein 2055026 2861204 SAR1962 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041337.1 2054712 R 282458 CDS YP_041338.1 49484114 2861205 complement(2055004..2055822) 1 NC_002952.2 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2055822 recX 2861205 recX Staphylococcus aureus subsp. aureus MRSA252 recombination regulator RecX YP_041338.1 2055004 R 282458 CDS YP_041339.1 49484115 2861206 complement(2056083..2056892) 1 NC_002952.2 monofunctional; catalyzes the elongation of glycan strands in cell wall biosynthesis; glycosyltransferase 2056892 2861206 SAR1964 Staphylococcus aureus subsp. aureus MRSA252 glycosyltransferase YP_041339.1 2056083 R 282458 CDS YP_041340.1 49484116 2861207 complement(2057233..2057748) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YraA SW:YRAA_BACSU (O06006) (154 aa) fasta scores: E(): 5.5e-29, 56.95% id in 151 aa, and to Escherichia coli hypothetical protein YhbO SW:YHBO_ECOLI (P45470) (172 aa) fasta scores: E(): 5.4e-28, 49.41% id in 172 aa; ThiJ/PfpI family protein 2057748 2861207 SAR1965 Staphylococcus aureus subsp. aureus MRSA252 ThiJ/PfpI family protein YP_041340.1 2057233 R 282458 CDS YP_041341.1 49484117 2861208 complement(2057878..2058039) 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YfjT TR:O35041 (EMBL:Z99108) (61 aa) fasta scores: E(): 0.0017, 42.3% id in 52 aa; hypothetical protein 2058039 2861208 SAR1966 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041341.1 2057878 R 282458 CDS YP_041342.1 49484118 2861209 2058263..2059414 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0889 TR:Q9KEG3 (EMBL:AP001510) (374 aa) fasta scores: E(): 2.2e-89, 56.38% id in 376 aa. N-terminus is similar to Bacillus subtilis hypothetical protein YfkA TR:O34400 (EMBL:Z99108) (154 aa) fasta scores: E(): 1.9e-35, 61.58% id in 151 aa. C-terminus is similar to Bacillus subtilis hypothetical protein YfkB TR:O34868 (EMBL:Z99108) (153 aa) fasta scores: E(): 1.9e-35, 63.94% id in 147 aa; hypothetical protein 2059414 2861209 SAR1967 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041342.1 2058263 D 282458 CDS YP_041343.1 49484119 2861210 complement(2059674..2060204) 1 NC_002952.2 Similar to Bacillus halodurans acyl-CoA thioester hydrolase BH2302 TR:Q9KAI5 (EMBL:AP001515) (162 aa) fasta scores: E(): 5.2e-23, 46.1% id in 154 aa, and to Bacillus subtilis acyl-CoA thioester hydrolase YkhA SW:YKHA_BACSU (P49851) (179 aa) fasta scores: E(): 1e-22, 50% id in 150 aa; hypothetical protein 2060204 2861210 SAR1968 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041343.1 2059674 R 282458 CDS YP_041344.1 49484120 2861211 complement(2060294..2061541) 1 NC_002952.2 Similar to Streptococcus thermophilus aminopeptidase PepS SW:PEPS_STRTR (Q9X4A7) (413 aa) fasta scores: E(): 9.9e-71, 46.48% id in 413 aa, and to Bacillus subtilis aminopeptidase AmpS SW:AMPS_BACSU (P39762) (410 aa) fasta scores: E(): 3.1e-73, 47.33% id in 412 aa; aminopeptidase 2061541 2861211 SAR1969 Staphylococcus aureus subsp. aureus MRSA252 aminopeptidase YP_041344.1 2060294 R 282458 CDS YP_041345.1 49484121 2861212 complement(2061553..2061768) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfkK TR:O35019 (EMBL:Z99108) (71 aa) fasta scores: E(): 0.0036, 40% id in 55 aa, and to Bacillus halodurans hypothetical protein BH2488 TR:Q9KA06 (EMBL:AP001515) (73 aa) fasta scores: E(): 0.0002, 39.7% id in 68 aa; hypothetical protein 2061768 2861212 SAR1970 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041345.1 2061553 R 282458 CDS YP_041346.1 49484122 2861213 2061900..2062364 1 NC_002952.2 Similar to Rattus norvegicus low molecular weight phosphotyrosine protein phosphatase AcP1 SW:PPAC_RAT (P41498) (159 aa) fasta scores: E(): 8.6e-13, 36.05% id in 147 aa, and to Bacillus subtilis hypothetical protein YfkJ TR:O35016 (EMBL:Z99108) (156 aa) fasta scores: E(): 5.2e-23, 45.57% id in 158 aa; low molecular weight phosphotyrosine protein phosphatase 2062364 2861213 SAR1971 Staphylococcus aureus subsp. aureus MRSA252 low molecular weight phosphotyrosine protein phosphatase YP_041346.1 2061900 D 282458 CDS YP_041347.1 49484123 2861214 2062371..2062646 1 NC_002952.2 hypothetical protein 2062646 2861214 SAR1972 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041347.1 2062371 D 282458 CDS YP_041348.1 49484124 2861215 2062924..2064141 1 NC_002952.2 C-terminal region is similar to Bacillus cereus hypothetical protein YfkH TR:Q9XBK8 (EMBL:AJ010131) (289 aa) fasta scores: E(): 1.2e-34, 37.18% id in 277 aa, and Bacillus subtilis hypothetical protein YfkH TR:O34437 (EMBL:Z99108) (275 aa) fasta scores: E(): 3.7e-33, 39.33% id in 272 aa. CDS contains extra residues at the N-terminus in comparison to orthologues; hypothetical protein 2064141 2861215 SAR1973 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041348.1 2062924 D 282458 CDS YP_041349.1 49484125 2861216 complement(2064254..2064883) 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Similar to Bacillus halodurans two-component response regulator BH1200 TR:Q9KDL2 (EMBL:AP001511) (209 aa) fasta scores: E(): 3e-36, 55.28% id in 208 aa, and to Lactococcus lactis two-component system regulator LlrD TR:Q9CH48 (EMBL:AE006323) (209 aa) fasta scores: E(): 5.3e-35, 53.88% id in 206 aa; response regulator 2064883 2861216 SAR1974 Staphylococcus aureus subsp. aureus MRSA252 response regulator YP_041349.1 2064254 R 282458 CDS YP_041350.1 49484126 2860430 complement(2064873..2065916) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus histidine kinase sensor, up-regulated in vancomycin-resistant strains, VraS TR:Q9KWK8 (EMBL:AB035448) (347 aa) fasta scores: E(): 3e-115, 99.71% id in 347 aa. Similar to Bacillus subtilis hypothetical protein YvqE TR:O32198 (EMBL:Z99120) (360 aa) fasta scores: E(): 8.9e-32, 40.47% id in 336 aa; histidine kinase sensor 2065916 vraS 2860430 vraS Staphylococcus aureus subsp. aureus MRSA252 histidine kinase sensor YP_041350.1 2064873 R 282458 CDS YP_041351.1 49484127 2861217 complement(2065913..2066614) 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY1623 TR:Q99YN1 (EMBL:AE006593) (228 aa) fasta scores: E(): 3.7e-05, 21.22% id in 212 aa, and to Bacillus subtilis hypothetical protein YvqF TR:O32199 (EMBL:Z99120) (241 aa) fasta scores: E(): 0.00046, 26.27% id in 236 aa; hypothetical protein 2066614 2861217 SAR1976 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041351.1 2065913 R 282458 CDS YP_041352.1 49484128 2861218 complement(2066629..2067015) 1 NC_002952.2 hypothetical protein 2067015 2861218 SAR1977 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041352.1 2066629 R 282458 CDS YP_041353.1 49484129 2861219 complement(2067232..2067990) 1 NC_002952.2 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 2067990 2861219 SAR1978 Staphylococcus aureus subsp. aureus MRSA252 methionine aminopeptidase YP_041353.1 2067232 R 282458 CDS YP_041354.1 49484130 2861220 2068690..2069676 1 NC_002952.2 N-terminus is similar to the N-terminal regions of Bacillus halodurans hypothetical protein BH2644 TR:Q9K9K2 (EMBL:AP001516) (354 aa) fasta scores: E(): 7.7e-26, 34.04% id in 279 aa, and Bacillus subtilis hypothetical protein YgaE TR:P71083 (EMBL:Z82044) (353 aa) fasta scores: E(): 3.1e-12, 29.79% id in 292 aa; hypothetical protein 2069676 2861220 SAR1980 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041354.1 2068690 D 282458 CDS YP_041355.1 49484131 2861221 complement(2069865..2070278) 1 NC_002952.2 No significant database matches. Possible alternative translational start sites; hypothetical protein 2070278 2861221 SAR1981 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041355.1 2069865 R 282458 CDS YP_041356.1 49484132 2861222 complement(2070503..2071234) 1 NC_002952.2 Similar to the C-terminal region of Pyrococcus kodakaraensis probable cobyric acid synthase CobQ SW:COBQ_PYRKO (O33475) (472 aa) fasta scores: E(): 0.00014, 26.88% id in 186 aa, and to the full length Heliobacillus mobilis cobyric acid synthase CobQ TR:Q9ZGG8 (EMBL:AF080002) (252 aa) fasta scores: E(): 5e-35, 48.61% id in 216 aa; hypothetical protein 2071234 2861222 SAR1982 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041356.1 2070503 R 282458 CDS YP_041357.1 49484133 2861732 complement(2071236..2072549) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YlbD TR:Q9CGJ0 (EMBL:AE006342) (449 aa) fasta scores: E(): 9.5e-42, 35.57% id in 447 aa, and to Heliobacillus mobilis UDP-N-acetylmuramyl tripeptide synthetase MurC TR:Q9ZGG7 (EMBL:AF080002) (455 aa) fasta scores: E(): 8.7e-27, 35.79% id in 447 aa; Mur ligase 2072549 2861732 SAR1983 Staphylococcus aureus subsp. aureus MRSA252 Mur ligase YP_041357.1 2071236 R 282458 CDS YP_041358.1 49484134 2861733 2072841..2073341 1 NC_002952.2 Similar to Escherichia coli ferritin 1 FtnA SW:FTNA_ECOLI (P23887) (165 aa) fasta scores: E(): 1e-18, 35.62% id in 160 aa, and to Bacillus halodurans ferritin BH1124 TR:Q9KDT7 (EMBL:AP001511) (169 aa) fasta scores: E(): 2.5e-33, 54.21% id in 166 aa; ferritin 2073341 2861733 SAR1984 Staphylococcus aureus subsp. aureus MRSA252 ferritin YP_041358.1 2072841 D 282458 CDS YP_041359.1 49484135 2861642 2073732..2074286 1 NC_002952.2 Similar to Caulobacter crescentus exonuclease CC1523 TR:Q9A841 (EMBL:AE005827) (202 aa) fasta scores: E(): 1.3e-13, 31.41% id in 156 aa, and to an internal region of Staphylococcus aureus DNA polymerase III PolC-type PolC SW:DPO3_STAAU (Q53665) (1436 aa) fasta scores: E(): 7.3e-08, 25.78% id in 190 aa; exonuclease 2074286 2861642 SAR1985 Staphylococcus aureus subsp. aureus MRSA252 exonuclease YP_041359.1 2073732 D 282458 CDS YP_041360.1 49484136 2859554 complement(2074353..2075423) 1 NC_002952.2 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 2075423 2859554 SAR1986 Staphylococcus aureus subsp. aureus MRSA252 DNA polymerase IV YP_041360.1 2074353 R 282458 CDS YP_041361.1 49484137 2859728 complement(2075670..2076200) 1 NC_002952.2 Similar to Streptococcus downei surface protein antigen gene repressor protein Par TR:Q06370 (EMBL:D13323) (203 aa) fasta scores: E(): 0.0071, 30.07% id in 143 aa, and to Streptococcus criceti probable surface antigen negative regulator Par TR:BAB59133 (EMBL:AB042239) (183 aa) fasta scores: E(): 0.01, 26.7% id in 161 aa; hypothetical protein 2076200 2859728 SAR1987 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041361.1 2075670 R 282458 CDS YP_041362.1 49484138 2859729 complement(2076370..2077731) 1 NC_002952.2 Similar to Bacillus halodurans RNA methyltransferase BH0687 TR:Q9KF10 (EMBL:AP001509) (458 aa) fasta scores: E(): 7.7e-89, 48.11% id in 451 aa, and to Bacillus subtilis hypothetical protein YefA TR:O31503 (EMBL:Z99107) (459 aa) fasta scores: E(): 4.8e-88, 49.66% id in 453 aa; RNA methyltransferase 2077731 2859729 SAR1988 Staphylococcus aureus subsp. aureus MRSA252 RNA methyltransferase YP_041362.1 2076370 R 282458 CDS YP_041363.1 49484139 2859730 complement(2077812..2078759) 1 NC_002952.2 similar to YegS from E. coli; lipid kinase 2078759 2859730 SAR1989 Staphylococcus aureus subsp. aureus MRSA252 lipid kinase YP_041363.1 2077812 R 282458 CDS YP_041364.1 49484140 2860692 complement(2079582..2081009) 1 NC_002952.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 2081009 gatB 2860692 gatB Staphylococcus aureus subsp. aureus MRSA252 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_041364.1 2079582 R 282458 CDS YP_041365.1 49484141 2860691 complement(2081022..2082479) 1 NC_002952.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 2082479 gatA 2860691 gatA Staphylococcus aureus subsp. aureus MRSA252 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_041365.1 2081022 R 282458 CDS YP_041366.1 49484142 2860693 complement(2082481..2082783) 1 NC_002952.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 2082783 gatC 2860693 gatC Staphylococcus aureus subsp. aureus MRSA252 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_041366.1 2082481 R 282458 CDS YP_041367.1 49484143 2860034 2083150..2084688 1 NC_002952.2 Similar to Staphylococcus aureus high affinity proline permease PutP TR:O30986 (EMBL:AF024571) (497 aa) fasta scores: E(): 5.5e-176, 97.97% id in 494 aa, and to Bacillus subtilis osmoregulated proline transporter OpuE SW:OPUE_BACSU (O06493) (492 aa) fasta scores: E(): 4.3e-100, 55.25% id in 476 aa; high affinity proline permease 2084688 putP 2860034 putP Staphylococcus aureus subsp. aureus MRSA252 high affinity proline permease YP_041367.1 2083150 D 282458 CDS YP_041368.1 49484144 2859731 complement(2084777..2085976) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YerH TR:O34629 (EMBL:Z99107) (396 aa) fasta scores: E(): 2.5e-43, 35.55% id in 405 aa, and to Bacillus halodurans hypothetical protein BH0650 TR:Q9KF36 (EMBL:AP001509) (392 aa) fasta scores: E(): 2.8e-21, 27.98% id in 411 aa; lipoprotein 2085976 2859731 SAR1995 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_041368.1 2084777 R 282458 CDS YP_041369.1 49484145 2859803 complement(2085989..2087992) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus DNA ligase Lig TR:Q9AIU7 (EMBL:AF234833) (667 aa) fasta scores: E(): 0, 99.55% id in 667 aa. Similar to Bacillus subtilis DNA ligase LigA SW:DNLJ_BACSU (O31498) (668 aa) fasta scores: E(): 4.1e-153, 61.79% id in 657 aa; DNA ligase 2087992 lig 2859803 lig Staphylococcus aureus subsp. aureus MRSA252 DNA ligase YP_041369.1 2085989 R 282458 CDS YP_041370.1 49484146 2859887 complement(2087996..2090188) 1 NC_002952.2 Similar to Bacillus subtilis ATP-dependent DNA helicase PcrA SW:PCRA_BACSU (O34580) (739 aa) fasta scores: E(): 6.1e-157, 59.73% id in 740 aa. Previously sequenced as Staphylococcus aureus ATP-dependent DNA helicase PcrA SW:PCRA_STAAU (Q53727) (675 aa) fasta scores: E(): 0, 99.85% id in 665 aa; ATP-dependent DNA helicase 2090188 pcrA 2859887 pcrA Staphylococcus aureus subsp. aureus MRSA252 ATP-dependent DNA helicase YP_041370.1 2087996 R 282458 CDS YP_041371.1 49484147 2859888 complement(2090185..2090877) 1 NC_002952.2 PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer; geranylgeranylglyceryl phosphate synthase 2090877 pcrB 2859888 pcrB Staphylococcus aureus subsp. aureus MRSA252 geranylgeranylglyceryl phosphate synthase YP_041371.1 2090185 R 282458 CDS YP_041372.1 49484148 2859732 complement(2091060..2091362) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YerC TR:O34975 (EMBL:Z99107) (104 aa) fasta scores: E(): 1.3e-24, 69.14% id in 94 aa, and to Bacillus halodurans hypothetical protein BH0639 TR:Q9KF47 (EMBL:AP001509) (100 aa) fasta scores: E(): 5.4e-24, 68.08% id in 94 aa; hypothetical protein 2091362 2859732 SAR1999 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041372.1 2091060 R 282458 CDS YP_041373.1 49484149 2860159 complement(2091471..2092766) 1 NC_002952.2 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 2092766 purB 2860159 purB Staphylococcus aureus subsp. aureus MRSA252 adenylosuccinate lyase YP_041373.1 2091471 R 282458 CDS YP_041374.1 49484150 2859733 2093617..2094783 1 NC_002952.2 Similar to Staphylococcus aureus cysteine protease (V8 protease) precursor BspB TR:Q9EYW7 (EMBL:AF309515) (393 aa) fasta scores: E(): 2.4e-47, 40.2% id in 398 aa. C-terminal region is identical to Staphylococcus aureus staphopain protease SW:STPA_STAAU (P81297) (174 aa) fasta scores: E(): 5.4e-64, 100% id in 174 aa; staphopain protease 2094783 2859733 SAR2001 Staphylococcus aureus subsp. aureus MRSA252 staphopain protease YP_041374.1 2093617 D 282458 CDS YP_041375.1 49484151 2859734 2094814..2095137 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus Ssp serine protease (V8 protease) operon hypothetical protein SspC TR:Q9EYW6 (EMBL:AF309515) (109 aa) fasta scores: E(): 9.6, 22.68% id in 97 aa; hypothetical protein 2095137 2859734 SAR2002 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041375.1 2094814 D 282458 CDS YP_041376.1 49484152 2859735 complement(2095431..2095604) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0622 TR:Q9KF64 (EMBL:AP001509) (65 aa) fasta scores: E(): 2.2e-07, 49.12% id in 57 aa, and to Bacillus subtilis hypothetical protein YebG TR:O34700 (EMBL:Z99107) (65 aa) fasta scores: E(): 2.1e-06, 43.1% id in 58 aa; hypothetical protein 2095604 2859735 SAR2003 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041376.1 2095431 R 282458 CDS YP_041377.1 49484153 2859736 complement(2095585..2096187) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0621 TR:Q9KF65 (EMBL:AP001509) (179 aa) fasta scores: E(): 1.3e-39, 60.11% id in 178 aa. N-terminal region is similar to Bacillus subtilis hypothetical protein YebE TR:O34695 (EMBL:Z99107) (80 aa) fasta scores: E(): 4.2e-11, 58.33% id in 72 aa. C-terminal region is similar to Bacillus subtilis hypothetical protein YebF TR:O34624 (EMBL:Z99107) (88 aa) fasta scores: E(): 2.3e-17, 59.09% id in 88 aa; hypothetical protein 2096187 2859736 SAR2004 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041377.1 2095585 R 282458 CDS YP_041378.1 49484154 2859737 complement(2096457..2097278) 1 NC_002952.2 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 2097278 nadE 2859737 nadE Staphylococcus aureus subsp. aureus MRSA252 NAD synthetase YP_041378.1 2096457 R 282458 CDS YP_041379.1 49484155 2859738 complement(2097271..2098740) 1 NC_002952.2 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 2098740 2859738 SAR2006 Staphylococcus aureus subsp. aureus MRSA252 nicotinate phosphoribosyltransferase YP_041379.1 2097271 R 282458 CDS YP_041380.1 49484156 2859739 2098924..2100000 1 NC_002952.2 Similar to an internal region of Homo sapiens inducible nitric oxide synthase NOS2 SW:NS2A_HUMAN (P35228) (1153 aa) fasta scores: E(): 4.5e-38, 42.13% id in 356 aa, and to the full length Bacillus halodurans nitric oxide synthase BH0823 TR:Q9KEM9 (EMBL:AP001509) (366 aa) fasta scores: E(): 3.4e-69, 50.43% id in 349 aa; oxygenase 2100000 2859739 SAR2007 Staphylococcus aureus subsp. aureus MRSA252 oxygenase YP_041380.1 2098924 D 282458 CDS YP_041381.1 49484157 2859740 2100020..2100814 1 NC_002952.2 Similar to the C-terminal region of Pseudomonas stutzeri bifunctional P-protein [includes: chorismate mutase, chorismate mutase/prephenate dehydratase] PheA SW:PHEA_PSEST (P27603) (365 aa) fasta scores: E(): 3.6e-18, 30.25% id in 271 aa, and to Methanococcus jannaschii probable prephenate dehydratase MJ0637 SW:PHEA_METJA (Q58054) (272 aa) fasta scores: E(): 7.6e-22, 33.33% id in 270 aa; prephenate dehydratase 2100814 2859740 SAR2008 Staphylococcus aureus subsp. aureus MRSA252 prephenate dehydratase YP_041381.1 2100020 D 282458 CDS YP_041382.1 49484158 2859741 complement(2101004..2102566) 1 NC_002952.2 Similar to Oryctolagus cuniculus renal sodium/dicarboxylate cotransporter NaDC-1 SW:NDC1_RABIT (Q28615) (593 aa) fasta scores: E(): 2.3e-21, 35.54% id in 543 aa, and to Arabidopsis thaliana sodium sulfate or dicarboxylate transporter TR:Q9MAW4 (EMBL:AB043024) (540 aa) fasta scores: E(): 1.2e-31, 33.19% id in 482 aa; sodium:sulfate symporter 2102566 2859741 SAR2009 Staphylococcus aureus subsp. aureus MRSA252 sodium:sulfate symporter YP_041382.1 2101004 R 282458 CDS YP_041383.1 49484159 2859742 complement(2102771..2103868) 1 NC_002952.2 Poor database matches. Similar to bacteriophage B103 pre-neck appendage protein (late protein gp12) SW:VG12_BPB03 (Q37893) (860 aa) fasta scores: E(): 0.012, 24.39% id in 373 aa; hypothetical protein 2103868 2859742 SAR2010 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041383.1 2102771 R 282458 CDS YP_041384.1 49484160 2859743 2104241..2104801 1 NC_002952.2 Similar to Mycobacterium smegmatis nicotinamidase/pyrazinamidase PncA TR:Q9ZF59 (EMBL:AF117900) (187 aa) fasta scores: E(): 1.1e-05, 30.67% id in 163 aa, and to Bacillus halodurans pyrazinamidase/nicotinamidase BH3777 TR:Q9K6F2 (EMBL:AP001520) (183 aa) fasta scores: E(): 6.2e-40, 54.74% id in 179 aa; isochorismatase 2104801 2859743 SAR2011 Staphylococcus aureus subsp. aureus MRSA252 isochorismatase YP_041384.1 2104241 D 282458 CDS YP_041385.1 49484161 2860000 2104848..2105783 1 NC_002952.2 catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase 2105783 ppaC 2860000 ppaC Staphylococcus aureus subsp. aureus MRSA252 manganese-dependent inorganic pyrophosphatase YP_041385.1 2104848 D 282458 CDS YP_041386.1 49484162 2859744 2106200..2107579 1 NC_002952.2 Similar to Homo sapiens fatty aldehyde dehydrogenase ALDH10 SW:DHA4_HUMAN (P51648) (485 aa) fasta scores: E(): 1.4e-78, 45.35% id in 452 aa, and to Bacillus subtilis probable aldehyde dehydrogenase ywdh ywdh or ipa-58R SW:DHA2_BACSU (P39616) (457 aa) fasta scores: E(): 8.3e-92, 50.78% id in 447 aa; aldehyde dehydrogenase 2107579 2859744 SAR2013 Staphylococcus aureus subsp. aureus MRSA252 aldehyde dehydrogenase YP_041386.1 2106200 D 282458 CDS YP_041387.1 49484163 2859745 complement(2107699..2108727) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkgB SW:YKGB_BACSU (O34499) (349 aa) fasta scores: E(): 3.4e-41, 37.79% id in 344 aa, and to Lactococcus lactis hypothetical protein SW:YADB_LACLC (O86281) (341 aa) fasta scores: E(): 2.1e-36, 34.6% id in 341 aa; hypothetical protein 2108727 2859745 SAR2014 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041387.1 2107699 R 282458 CDS YP_041388.1 49484164 2859746 2108998..2109399 1 NC_002952.2 C-terminal region is similar to Bacillus anthracis plasmid pXO2 hypothetical protein pXO2-70 TR:Q9RMW4 (EMBL:AF188935) (113 aa) fasta scores: E(): 8.7e-10, 35.13% id in 111 aa, and bacteriophage SPBc2 hypothetical protein YolD TR:O64030 (EMBL:AF020713) (110 aa) fasta scores: E(): 8.1e-07, 39.02% id in 82 aa; hypothetical protein 2109399 2859746 SAR2015 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041388.1 2108998 D 282458 CDS YP_041389.1 49484165 2859747 complement(2109456..2109629) 1 NC_002952.2 hypothetical protein 2109629 2859747 SAR2016 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041389.1 2109456 R 282458 CDS YP_041390.1 49484166 2859748 2110080..2111120 1 NC_002952.2 Poor database matches. N-terminus is weakly similar to the N-terminal region of Rhizobium loti acyl-CoA-6-aminopenicillanic acid acyltransferase MLL9373 TR:BAB54980 (EMBL:AP003016) (334 aa) fasta scores: E(): 0.017, 21.56% id in 269 aa; hypothetical protein 2111120 2859748 SAR2017 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041390.1 2110080 D 282458 CDS YP_041391.1 49484167 2859749 complement(2111177..2112019) 1 NC_002952.2 Poor database matches. Similar to the N-terminal regions of Staphylococcus sciuri penicillin-binding protein 2' MecA TR:O54286 (EMBL:Y13096) (668 aa) fasta scores: E(): 3.8, 22.93% id in 279 aa, and to Staphylococcus epidermidis penicillin binding protein 2' MecA TR:Q54113 (EMBL:X52592) (668 aa) fasta scores: E(): 4.4, 23.29% id in 279 aa; hypothetical protein 2112019 2859749 SAR2018 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041391.1 2111177 R 282458 CDS YP_041392.1 49484168 2859750 complement(2112016..2112573) 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY2173 TR:Q99XJ8 (EMBL:AE006634) (195 aa) fasta scores: E(): 0.0068, 27% id in 200 aa, and to Caulobacter crescentus hypothetical protein CC3409 TR:Q9A2Z7 (EMBL:AE006001) (187 aa) fasta scores: E(): 0.011, 22.77% id in 180 aa; hypothetical protein 2112573 2859750 SAR2019 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041392.1 2112016 R 282458 CDS YP_041393.1 49484169 2859751 complement(2112633..2113157) 1 NC_002952.2 Poor database matches. Weakly similar to Candidatus Carsonella ruddii alkyl hydroperoxide reductase small subunit AhpC TR:Q9AIZ1 (EMBL:AF211134) (177 aa) fasta scores: E(): 10, 21.89% id in 169 aa; hypothetical protein 2113157 2859751 SAR2020 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041393.1 2112633 R 282458 CDS YP_041394.1 49484170 2859752 2113278..2113841 1 NC_002952.2 Poor database matches. Weakly similar to Arabidopsis thaliana thioredoxin-like protein TR:Q9LVI2 (EMBL:AB019230) (175 aa) fasta scores: E(): 0.8, 25.82% id in 151 aa; hypothetical protein 2113841 2859752 SAR2021 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041394.1 2113278 D 282458 CDS YP_041395.1 49484171 2859753 complement(2113905..2114645) 1 NC_002952.2 Weakly similar to Staphylococcus epidermidis membrane spanning protein SmpA TR:Q54139 (EMBL:Z30586) (256 aa) fasta scores: E(): 0.00053, 23.75% id in 261 aa, and to Staphylococcus hominis potential membrane spanning protein SmpB TR:Q54315 (EMBL:Z30587) (256 aa) fasta scores: E(): 0.00068, 24.52% id in 261 aa; hypothetical protein 2114645 2859753 SAR2022 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041395.1 2113905 R 282458 CDS YP_041396.1 49484172 2859754 complement(2114645..2115517) 1 NC_002952.2 Similar to Streptococcus pyogenes ABC transporter SPY1784 TR:Q99YB1 (EMBL:AE006605) (300 aa) fasta scores: E(): 1.3e-19, 33.21% id in 286 aa, and to Staphylococcus aureus potential ABC transporter StpC TR:Q53763 (EMBL:Z30588) (231 aa) fasta scores: E(): 1.9e-19, 41.9% id in 210 aa; ABC transporter ATP-binding protein 2115517 2859754 SAR2023 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041396.1 2114645 R 282458 CDS YP_041397.1 49484173 2859755 complement(2115514..2116194) 1 NC_002952.2 Similar to Phytophthora infestans mitochondrial SecY-independent transporter protein YMF16 TR:Q9T238 (EMBL:U17009) (248 aa) fasta scores: E(): 0.079, 26.57% id in 207 aa, and to Pyrococcus horikoshii hypothetical protein PH1493 TR:O59162 (EMBL:AP000006) (232 aa) fasta scores: E(): 0.2, 24.87% id in 205 aa; hypothetical protein 2116194 2859755 SAR2024 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041397.1 2115514 R 282458 CDS YP_041398.1 49484174 2859756 complement(2116195..2117091) 1 NC_002952.2 Similar to Bacillus halodurans ABC transporter BH0652 TR:Q9KF34 (EMBL:AP001509) (288 aa) fasta scores: E(): 6.4e-37, 42.85% id in 280 aa, and to Thermotoga maritima ABC transporter ATP-binding protein TM1028 TR:Q9X0B8 (EMBL:AE001764) (293 aa) fasta scores: E(): 1.8e-18, 31.46% id in 286 aa; ABC transporter ATP-binding protein 2117091 2859756 SAR2025 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041398.1 2116195 R 282458 CDS YP_041399.1 49484175 2859757 complement(2117088..2117543) 1 NC_002952.2 Similar to Bacillus halodurans transcriptional regulator BH0651 TR:Q9KF35 (EMBL:AP001509) (123 aa) fasta scores: E(): 1.3e-18, 52.03% id in 123 aa, and to Bacillus firmus hypothetical protein TR:O87562 (EMBL:AF084104) (119 aa) fasta scores: E(): 5.3e-11, 40.17% id in 117 aa; GntR family transcriptional regulator 2117543 2859757 SAR2026 Staphylococcus aureus subsp. aureus MRSA252 GntR family transcriptional regulator YP_041399.1 2117088 R 282458 CDS YP_041400.1 49484176 2859758 complement(2117726..2117902) 1 NC_002952.2 hypothetical protein 2117902 2859758 SAR2027 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041400.1 2117726 R 282458 CDS YP_041401.1 49484177 2859759 complement(2118144..2118242) 1 NC_002952.2 Doubtful CDS. No database matches; hypothetical protein 2118242 2859759 SAR2027a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041401.1 2118144 R 282458 CDS YP_041402.1 49484178 2859760 2118442..2119728 1 NC_002952.2 Similar to Bacillus circulans aspartate aminotransferase TR:Q59197 (EMBL:X94433) (432 aa) fasta scores: E(): 4e-70, 46.65% id in 433 aa. N-terminus is similar to the N-terminal region of Escherichia coli aspartate aminotransferase AspC SW:AAT_ECOLI (P00509) (396 aa) fasta scores: E(): 3.5e-07, 23.19% id in 332 aa; hypothetical protein 2119728 2859760 SAR2028 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041402.1 2118442 D 282458 CDS YP_041403.1 49484179 2859761 complement(2119976..2121622) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 1e-198, 99.270% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 4.7e-99, 51.923% id in 520 aa; transposase 2121622 2859761 SAR2029 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_041403.1 2119976 R 282458 CDS YP_041404.1 49484180 2859762 complement(2121920..2123989) 1 NC_002952.2 Similar to Staphylococcus aureus mammalian extracellular protein-binding protein, major histocompatibility complex (MHC) class III analog TR:Q53599 (EMBL:U20503) (689 aa) fasta scores: E(): 0, 94.77% id in 689 aa; MHC class II analog 2123989 2859762 SAR2030 Staphylococcus aureus subsp. aureus MRSA252 MHC class II analog YP_041404.1 2121920 R 282458 CDS YP_041405.1 49484181 2859763 2124947..2125126 1 NC_002952.2 hypothetical protein 2125126 2859763 SAR2032 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041405.1 2124947 D 282458 CDS YP_041406.1 49484182 2859764 2125150..2125458 1 NC_002952.2 hypothetical protein 2125458 2859764 SAR2033 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041406.1 2125150 D 282458 CDS YP_041407.1 49484183 2861484 2125437..2125697 1 NC_002952.2 hypothetical protein 2125697 2861484 SAR2034 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041407.1 2125437 D 282458 CDS YP_041408.1 49484184 2861485 complement(2125750..2126100) 1 NC_002952.2 No significant database matches. Similar to SAR1131, 50.000% identity (50.893% ungapped) in 114 aa overlap; hypothetical protein 2126100 2861485 SAR2035 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041408.1 2125750 R 282458 CDS YP_041409.1 49484185 2861356 2126786..2127235 1 NC_002952.2 secreted protein that specifically inhibits the activation of neutrophils and monocytes by binding to the formylated peptide receptor and the C5a receptor; blocks neutrophil migration towards the infection site and hinders the establishment of the initial defense against the infection; chemotaxis-inhibiting protein CHIPS 2127235 chp 2861356 chp Staphylococcus aureus subsp. aureus MRSA252 chemotaxis-inhibiting protein CHIPS YP_041409.1 2126786 D 282458 CDS YP_041410.1 49484186 2861465 complement(2128315..2128806) 1 NC_002952.2 Highly similar to Staphylococcus aureus plasminogen activator staphylokinase precursor Sak SW:SAK_STAAU (P00802) (163 aa) fasta scores: E(): 9.5e-61, 98.77% id in 163 aa, and to bacteriophage P42D staphylokinase precursor Sak SW:SAK_BPP42 (P15240) (163 aa) fasta scores: E(): 2.2e-59, 97.54% id in 163 aa; staphylokinase precursor 2128806 sak 2861465 sak Staphylococcus aureus subsp. aureus MRSA252 staphylokinase precursor YP_041410.1 2128315 R 282458 CDS YP_041411.1 49484187 2861487 complement(2128998..2129753) 1 NC_002952.2 Similar to the N-terminal region of Staphylococcus aureus autolysin, peptidoglycan hydrolase (N-acetylmuramyl-L-alanine amidase) LytA SW:ALYS_STAAU (P24556) (481 aa) fasta scores: E(): 6.3e-08, 29.61% id in 260 aa, and to the full length Staphylococcus aureus prophage phiPV83 lytic enzyme (N-acetylmuramyl-L-alanine amidase) TR:Q9MBN4 (EMBL:AB044554) (251 aa) fasta scores: E(): 1.6e-108, 98.8% id in 251 aa. Possible gene remnant; autolysin 2129753 2861487 SAR2040 Staphylococcus aureus subsp. aureus MRSA252 autolysin YP_041411.1 2128998 R 282458 CDS YP_041412.1 49484188 2861488 complement(2129765..2130019) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 holin TR:Q9MBN5 (EMBL:AB044554) (84 aa) fasta scores: E(): 3.8e-32, 98.81% id in 84 aa, and to bacteriophage TP901-1 Hol TR:Q9AZ53 (EMBL:AF304433) (88 aa) fasta scores: E(): 5.9e-11, 43.75% id in 80 aa; holin 2130019 2861488 SAR2041 Staphylococcus aureus subsp. aureus MRSA252 holin YP_041412.1 2129765 R 282458 CDS YP_041413.1 49484189 2861489 complement(2130231..2130416) 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 2130416 2861489 SAR2042 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041413.1 2130231 R 282458 CDS YP_041414.1 49484190 2861490 complement(2130516..2131289) 1 NC_002952.2 Similar to Staphylococcus aureus enterotoxin type A precursor EntA SW:ETXA_STAAU (P13163) (257 aa) fasta scores: E(): 1.7e-98, 98.05% id in 257 aa, and to Staphylococcus aureus enterotoxin type E precursor EntE SW:ETXE_STAAU (P12993) (257 aa) fasta scores: E(): 1.2e-82, 82.87% id in 257 aa; enterotoxin type A precursor 2131289 2861490 SAR2043 Staphylococcus aureus subsp. aureus MRSA252 enterotoxin type A precursor YP_041414.1 2130516 R 282458 CDS YP_041415.1 49484191 2861491 complement(2131407..2131601) 1 NC_002952.2 Doubtful CDS. No significant database hits; hypothetical protein 2131601 2861491 SAR2044 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041415.1 2131407 R 282458 CDS YP_041416.1 49484192 2861492 complement(2131710..2132084) 1 NC_002952.2 Poor database matches. Similar to the C-terminal region of Borrelia hermsii hypothetical protein BdrC1 TR:Q9RG81 (EMBL:AF143476) (238 aa) fasta scores: E(): 3, 24.4% id in 127 aa; hypothetical protein 2132084 2861492 SAR2045 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041416.1 2131710 R 282458 CDS YP_041417.1 49484193 2861493 complement(2132140..2132427) 1 NC_002952.2 Identical to bacteriophage phi PVL hypothetical protein Orf 22 TR:O80061 (EMBL:AB009866) (95 aa) fasta scores: E(): 2.6e-31, 100% id in 95 aa. Similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf 22 homologue TR:Q9MBN7 (EMBL:AB044554) (95 aa) fasta scores: E(): 2.1e-28, 91.57% id in 95 aa; hypothetical protein 2132427 2861493 SAR2046 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041417.1 2132140 R 282458 CDS YP_041418.1 49484194 2861494 complement(2132474..2132626) 1 NC_002952.2 Identical to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 55 TR:Q9MBN8 (EMBL:AB044554) (50 aa) fasta scores: E(): 2e-19, 100% id in 50 aa; hypothetical protein 2132626 2861494 SAR2047 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041418.1 2132474 R 282458 CDS YP_041419.1 49484195 2861495 complement(2132616..2136401) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf 20 and 21 homologues TR:Q9MBN9 (EMBL:AB044554) (1261 aa) fasta scores: E(): 0, 97.78% id in 1261 aa. N-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 20 TR:O80059 (EMBL:AB009866) (759 aa) fasta scores: E(): 0, 99.46% id in 752 aa. C-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 21 TR:O80060 (EMBL:AB009866) (418 aa) fasta scores: E(): 5.2e-131, 99.76% id in 418 aa. Contains coiled-coiled domain, residues 714 to 735; hypothetical protein 2136401 2861495 SAR2048 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041419.1 2132616 R 282458 CDS YP_041420.1 49484196 2861496 complement(2136417..2137901) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf 18 and 19 homologues TR:Q9MBP0 (EMBL:AB044554) (496 aa) fasta scores: E(): 1.4e-180, 88.91% id in 496 aa. N-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 18 TR:O80057 (EMBL:AB009866) (119 aa) fasta scores: E(): 3.7e-23, 60.52% id in 114 aa. C-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 19 TR:O80058 (EMBL:AB009866) (377 aa) fasta scores: E(): 3.7e-152, 99.46% id in 377 aa; hypothetical protein 2137901 2861496 SAR2049 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041420.1 2136417 R 282458 CDS YP_041421.1 49484197 2861497 complement(2137898..2142427) 1 NC_002952.2 No significant database matches to the full length CDS. N-terminal region is similar to similar to bacteriophage phi PVL hypothetical protein Orf 15 TR:O80054 (EMBL:AB009866) (694 aa) fasta scores: E(): 5.7e-22, 28.4% id in 704 aa. Internal region is similar to bacteriophage phi PVL hypothetical protein Orf 16 TR:O80055 (EMBL:AB009866) (539 aa) fasta scores: E(): 2.2e-150, 82.97% id in 517 aa. C-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 17 TR:O80056 (EMBL:AB009866) (223 aa) fasta scores: E(): 2.5e-36, 55.55% id in 225 aa; hypothetical protein 2142427 2861497 SAR2050 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041421.1 2137898 R 282458 CDS YP_041422.1 49484198 2861498 complement(2142484..2142645) 1 NC_002952.2 No significant database matches. Possible alternative translational start sites; hypothetical protein 2142645 2861498 SAR2051 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041422.1 2142484 R 282458 CDS YP_041423.1 49484199 2861499 complement(2142672..2143022) 1 NC_002952.2 Poor database matches. C-terminus is similar to the C-terminal regions of bacteriophage phi PVL hypothetical protein Orf 14 TR:O80053 (EMBL:AB009866) (148 aa) fasta scores: E(): 2.4, 28.76% id in 73 aa, and to Staphylococcus aureus prophage phiPV83 phi PVL Orf 14 homologue TR:Q9MBP3 (EMBL:AB044554) (148 aa) fasta scores: E(): 1.3, 28.76% id in 73 aa; hypothetical protein 2143022 2861499 SAR2052 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041423.1 2142672 R 282458 CDS YP_041424.1 49484200 2861500 complement(2143072..>2143353) 1 NC_002952.2 Similar to bacteriophage A118 gp13 TR:Q9T1B0 (EMBL:AJ242593) (110 aa) fasta scores: E(): 0.36, 28.23% id in 85 aa, and to the C-terminal region of bacteriophage phi PVL hypothetical protein Orf 13 TR:O80052 (EMBL:AB009866) (317 aa) fasta scores: E(): 0.00058, 38.09% id in 84 aa; hypothetical protein >2143353 2861500 SAR2053 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041424.1 2143072 R 282458 CDS YP_041425.1 49484201 2861501 complement(2143338..2143982) 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of bacteriophage phi PVL hypothetical protein Orf 13 TR:O80052 (EMBL:AB009866) (317 aa) fasta scores: E(): 0.12, 23.83% id in 193 aa; hypothetical protein 2143982 2861501 SAR2054 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041425.1 2143338 R 282458 CDS YP_041426.1 49484202 2861502 complement(2143983..2144390) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf131b TR:Q9B0D6 (EMBL:AB045978) (131 aa) fasta scores: E(): 0.015, 28.46% id in 137 aa; hypothetical protein 2144390 2861502 SAR2055 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041426.1 2143983 R 282458 CDS YP_041427.1 49484203 2861504 complement(2144787..2145149) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 10 TR:O80049 (EMBL:AB009866) (111 aa) fasta scores: E(): 3.8e-06, 30.27% id in 109 aa, and to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf110 TR:Q9B0D8 (EMBL:AB045978) (110 aa) fasta scores: E(): 0.00034, 26% id in 100 aa; hypothetical protein 2145149 2861504 SAR2058 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041427.1 2144787 R 282458 CDS YP_041428.1 49484204 2861505 complement(2145133..2145417) 1 NC_002952.2 hypothetical protein 2145417 2861505 SAR2059 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041428.1 2145133 R 282458 CDS YP_041429.1 49484205 2861506 complement(2145407..2145691) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3526 TR:Q9K747 (EMBL:AP001519) (80 aa) fasta scores: E(): 0.03, 32.92% id in 82 aa, and to bacteriophage phi ETA hypothetical protein Orf45 TR:Q9G000 (EMBL:AP001553) (108 aa) fasta scores: E(): 0.67, 26.66% id in 105 aa; hypothetical protein 2145691 2861506 SAR2060 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041429.1 2145407 R 282458 CDS YP_041430.1 49484206 2861507 complement(2145711..2146856) 1 NC_002952.2 hypothetical protein 2146856 2861507 SAR2061 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041430.1 2145711 R 282458 CDS YP_041431.1 49484207 2861508 complement(2146880..2147617) 1 NC_002952.2 Similar to Streptococcus thermophilus bacteriophage DT1 scaffolding protein TR:Q9XJA0 (EMBL:AF085222) (222 aa) fasta scores: E(): 6.5e-25, 43.33% id in 210 aa, and to Streptococcus thermophilus bacteriophage Sfi21 clp-protease Orf221 TR:Q9XJ78 (EMBL:AF115103) (224 aa) fasta scores: E(): 1.8e-23, 40.48% id in 205 aa; Clp protease 2147617 2861508 SAR2062 Staphylococcus aureus subsp. aureus MRSA252 Clp protease YP_041431.1 2146880 R 282458 CDS YP_041432.1 49484208 2861509 complement(2147601..2148788) 1 NC_002952.2 Similar to bacteriophage bIL285 portal protein Orf42 TR:Q9AZY7 (EMBL:AF323668) (413 aa) fasta scores: E(): 0.0016, 23.96% id in 388 aa, and to bacteriophage phi-105 hypothetical protein Orf25 TR:Q9ZXF8 (EMBL:AB016282) (416 aa) fasta scores: E(): 0.027, 22.08% id in 403 aa; hypothetical protein 2148788 2861509 SAR2063 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041432.1 2147601 R 282458 CDS YP_041433.1 49484209 2861510 complement(2148804..2150465) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT terminase large subunit TR:Q9B0E3 (EMBL:AB045978) (563 aa) fasta scores: E(): 1.7e-27, 27.55% id in 548 aa, and to bacteriophage phi PVL hypothetical protein Orf 2 TR:O80041 (EMBL:AB009866) (564 aa) fasta scores: E(): 4.1e-19, 22.6% id in 553 aa; hypothetical protein 2150465 2861510 SAR2064 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041433.1 2148804 R 282458 CDS YP_041434.1 49484210 2861511 complement(2150462..2150806) 1 NC_002952.2 hypothetical protein 2150806 2861511 SAR2065 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041434.1 2150462 R 282458 CDS YP_041435.1 49484211 2861512 complement(2150829..2150942) 1 NC_002952.2 hypothetical protein 2150942 2861512 SAR2065a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041435.1 2150829 R 282458 CDS YP_041436.1 49484212 2861513 complement(2150936..2151235) 1 NC_002952.2 Similar to the C-terminal regions of Streptococcus thermophilus bacteriophage Sfi21 hypothetical protein TR:Q9XJW4 (EMBL:AF112470) (175 aa) fasta scores: E(): 4e-06, 38.37% id in 86 aa, and bacteriophage bIL285 hypothetical protein Orf39 TR:Q9AZZ0 (EMBL:AF323668) (150 aa) fasta scores: E(): 4.7e-06, 42.1% id in 76 aa; hypothetical protein 2151235 2861513 SAR2066 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041436.1 2150936 R 282458 CDS YP_041437.1 49484213 2861514 complement(2151467..2151883) 1 NC_002952.2 Similar to bacteriophage r1t hypothetical protein Orf25 TR:Q38111 (EMBL:U38906) (143 aa) fasta scores: E(): 0.0027, 26.35% id in 129 aa, and to Lactococcus bacteriophage phi31 transcriptional activator of phage 31 late promoter TR:O64272 (EMBL:AF022773) (143 aa) fasta scores: E(): 0.0027, 26.35% id in 129 aa; hypothetical protein 2151883 2861514 SAR2067 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041437.1 2151467 R 282458 CDS YP_041438.1 49484214 2861515 complement(2151911..2152114) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 60 TR:O80098 (EMBL:AB009866) (67 aa) fasta scores: E(): 7.2e-24, 95.52% id in 67 aa, and to Staphylococcus aureus prophage phiPV83 phi PVL orf 60 homologue TR:Q9MBQ6 (EMBL:AB044554) (66 aa) fasta scores: E(): 1.6e-24, 100% id in 66 aa; hypothetical protein 2152114 2861515 SAR2068 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041438.1 2151911 R 282458 CDS YP_041439.1 49484215 2861516 complement(2152111..2152260) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 57 TR:O80095 (EMBL:AB009866) (54 aa) fasta scores: E(): 3.9e-19, 93.87% id in 49 aa, and to Staphylococcus aureus prophage phiPV83 phi PVL Orf 57 / phi 11 RinB homologue TR:Q9MBQ7 (EMBL:AB044554) (49 aa) fasta scores: E(): 4.4e-19, 95.91% id in 49 aa. Similar to SAR1527, 87.755% identity (89.583% ungapped) in 49 aa overlap; hypothetical protein 2152260 2861516 SAR2069 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041439.1 2152111 R 282458 CDS YP_041440.1 49484216 2861517 complement(2152257..2152643) 1 NC_002952.2 Identical to bacteriophage phi ETA hypothetical protein Orf36 TR:Q9G009 (EMBL:AP001553) (128 aa) fasta scores: E(): 4.5e-45, 100% id in 128 aa. Similar to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf31 TR:Q9MBQ8 (EMBL:AB044554) (130 aa) fasta scores: E(): 2.2e-40, 91.33% id in 127 aa; hypothetical protein 2152643 2861517 SAR2070 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041440.1 2152257 R 282458 CDS YP_041441.1 49484217 2861518 complement(2152640..2152846) 1 NC_002952.2 Similar to bacteriophage phi ETA hypothetical protein Orf35 TR:Q9G010 (EMBL:AP001553) (68 aa) fasta scores: E(): 2.7e-23, 98.52% id in 68 aa, and to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf77 TR:Q9B0F0 (EMBL:AB045978) (77 aa) fasta scores: E(): 1.4e-12, 95.55% id in 45 aa. Similar to SAR1529, 78.723% identity (78.723% ungapped) in 47 aa overlap; hypothetical protein 2152846 2861518 SAR2071 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041441.1 2152640 R 282458 CDS YP_041442.1 49484218 2861519 complement(2152883..2153425) 1 NC_002952.2 Similar to bacteriophage phi PVL dUTP pyrophosphatase (dUTPase) TR:O80091 (EMBL:AB009866) (175 aa) fasta scores: E(): 2.5e-30, 78.26% id in 184 aa, and to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 53 homologue TR:Q9B0F2 (EMBL:AB045978) (175 aa) fasta scores: E(): 1.2e-46, 77.17% id in 184 aa; dUTP pyrophosphatase 2153425 2861519 SAR2072 Staphylococcus aureus subsp. aureus MRSA252 dUTP pyrophosphatase YP_041442.1 2152883 R 282458 CDS YP_041443.1 49484219 2861520 complement(2153418..2153600) 1 NC_002952.2 hypothetical protein 2153600 2861520 SAR2073 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041443.1 2153418 R 282458 CDS YP_041444.1 49484220 2861521 complement(2153590..2153841) 1 NC_002952.2 Similar to bacteriophage phi ETA hypothetical protein Orf32 TR:Q9G013 (EMBL:AP001553) (80 aa) fasta scores: E(): 5.8e-25, 95% id in 80 aa, and to bacteriophage phi PVL hypothetical protein Orf 52 TR:O80090 (EMBL:AB009866) (82 aa) fasta scores: E(): 9.7e-23, 85.36% id in 82 aa. Similar to SAR1532, 82.927% identity (82.927% ungapped) in 82 aa overlap; hypothetical protein 2153841 2861521 SAR2074 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041444.1 2153590 R 282458 CDS YP_041445.1 49484221 2861522 complement(2153834..2154007) 1 NC_002952.2 Identical to the C-terminal region of bacteriophage phi ETA hypothetical protein Orf29 TR:Q9G016 (EMBL:AP001553) (139 aa) fasta scores: E(): 8.2e-23, 100% id in 56 aa. Possible C-terminal region of a pseudogene; hypothetical protein 2154007 2861522 SAR2075 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041445.1 2153834 R 282458 CDS YP_041446.1 49484222 2861523 complement(2154013..2154255) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 51 TR:O80089 (EMBL:AB009866) (80 aa) fasta scores: E(): 1.2e-29, 92.5% id in 80 aa. Similar to the N-terminus of bacteriophage phi ETA hypothetical protein Orf29 TR:Q9G016 (EMBL:AP001553) (139 aa) fasta scores: E(): 2e-21, 90.47% id in 63 aa. Possible N-terminal region of a pseudogene. Similar to SAR1536, 82.500% identity (82.500% ungapped) in 80 aa overlap; hypothetical protein 2154255 2861523 SAR2076 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041446.1 2154013 R 282458 CDS YP_041447.1 49484223 2861524 complement(2154259..2154627) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 50 TR:O80088 (EMBL:AB009866) (122 aa) fasta scores: E(): 5e-41, 97.54% id in 122 aa, and to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 50 homologue TR:Q9B0F5 (EMBL:AB045978) (122 aa) fasta scores: E(): 1.2e-39, 92.62% id in 122 aa; hypothetical protein 2154627 2861524 SAR2077 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041447.1 2154259 R 282458 CDS YP_041448.1 49484224 2860092 complement(2154958..2155176) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 47 TR:O80086 (EMBL:AB009866) (72 aa) fasta scores: E(): 1.2e-29, 98.61% id in 72 aa; hypothetical protein 2155176 2860092 SAR2080 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041448.1 2154958 R 282458 CDS YP_041449.1 49484225 2860094 complement(2156086..2156556) 1 NC_002952.2 Similar to bacteriophage phi PVL single-strand DNA-binding protein TR:O80084 (EMBL:AB009866) (156 aa) fasta scores: E(): 1.9e-55, 96.15% id in 156 aa, and to bacteriophage A118 ssDNA binding protein Ssb TR:Q9T160 (EMBL:AJ242593) (160 aa) fasta scores: E(): 6.2e-31, 56.87% id in 160 aa. Similar to SAR0363, 68.862% identity (73.718% ungapped) in 167 aa overlap; single-strand DNA-binding protein 2156556 2860094 SAR2083 Staphylococcus aureus subsp. aureus MRSA252 single-strand DNA-binding protein YP_041449.1 2156086 R 282458 CDS YP_041450.1 49484226 2860095 complement(2156557..2157042) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 44 TR:O80083 (EMBL:AB009866) (161 aa) fasta scores: E(): 2.1e-60, 97.51% id in 161 aa; hypothetical protein 2157042 2860095 SAR2084 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041450.1 2156557 R 282458 CDS YP_041451.1 49484227 2860096 complement(2157255..2158175) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 43 TR:O80082 (EMBL:AB009866) (306 aa) fasta scores: E(): 7.5e-105, 99.67% id in 306 aa, and to Legionella pneumophila hypothetical protein TR:Q9AKZ0 (EMBL:AJ277755) (294 aa) fasta scores: E(): 0.36, 23.85% id in 306 aa; hypothetical protein 2158175 2860096 SAR2085 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041451.1 2157255 R 282458 CDS YP_041452.1 49484228 2860097 complement(2158177..2160120) 1 NC_002952.2 Similar to N-terminal region of Thermoplasma volcanium purine NTPase TVG0235331 TR:BAB59370 (EMBL:AP000991) (895 aa) fasta scores: E(): 1.9e-05, 22.72% id in 691 aa. C-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 41 TR:O80080 (EMBL:AB009866) (332 aa) fasta scores: E(): 2.1e-85, 98.11% id in 318 aa. N-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 42 TR:O80081 (EMBL:AB009866) (273 aa) fasta scores: E(): 2.2e-69, 98.16% id in 273 aa; hypothetical protein 2160120 2860097 SAR2086 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041452.1 2158177 R 282458 CDS YP_041453.1 49484229 2860098 complement(2160129..2160407) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 40 TR:O80079 (EMBL:AB009866) (92 aa) fasta scores: E(): 2e-34, 98.91% id in 92 aa; hypothetical protein 2160407 2860098 SAR2087 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041453.1 2160129 R 282458 CDS YP_041454.1 49484230 2860099 complement(2160401..2160661) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 39 TR:O80078 (EMBL:AB009866) (86 aa) fasta scores: E(): 2.6e-13, 51.16% id in 86 aa, and to bacteriophage phi ETA hypothetical protein Orf15 TR:Q9G030 (EMBL:AP001553) (86 aa) fasta scores: E(): 6.8e-13, 48.83% id in 86 aa; hypothetical protein 2160661 2860099 SAR2088 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041454.1 2160401 R 282458 CDS YP_041455.1 49484231 2860100 complement(2160642..2160968) 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf100a TR:Q9B0G6 (EMBL:AB045978) (100 aa) fasta scores: E(): 1.9e-17, 52% id in 100 aa; hypothetical protein 2160968 2860100 SAR2089 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041455.1 2160642 R 282458 CDS YP_041456.1 49484232 2860101 complement(2160965..2161066) 1 NC_002952.2 No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 2161066 2860101 SAR2090 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041456.1 2160965 R 282458 CDS YP_041457.1 49484233 2860102 complement(2161063..2161224) 1 NC_002952.2 Similar to bacteriophage phi ETA hypothetical protein Orf14 TR:Q9G031 (EMBL:AP001553) (53 aa) fasta scores: E(): 2.2e-18, 94.34% id in 53 aa, and to bacteriophage phi PVL hypothetical protein Orf 38 TR:O80077 (EMBL:AB009866) (53 aa) fasta scores: E(): 7.7e-18, 92.45% id in 53 aa. Similar to SAR1546, 92.453% identity (92.453% ungapped) in 53 aa overlap; hypothetical protein 2161224 2860102 SAR2091 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041457.1 2161063 R 282458 CDS YP_041458.1 49484234 2860103 complement(2161221..2161541) 1 NC_002952.2 Similar to Lactococcus lactis prophage pi1 protein 09 TR:Q9CIC0 (EMBL:AE006281) (109 aa) fasta scores: E(): 0.003, 32.99% id in 97 aa, and to bacteriophage bIL309 hypothetical protein Orf9 TR:Q9AZQ3 (EMBL:AF323670) (109 aa) fasta scores: E(): 0.003, 32.99% id in 97 aa; hypothetical protein 2161541 2860103 SAR2092 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041458.1 2161221 R 282458 CDS YP_041459.1 49484235 2860104 2161597..2162232 1 NC_002952.2 Poor database matches. C-terminus is similar to the C-terminal region of bacteriophage phi ETA hypothetical protein Orf12 TR:Q9G033 (EMBL:AP001553) (221 aa) fasta scores: E(): 0.014, 25% id in 124 aa; hypothetical protein 2162232 2860104 SAR2093 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041459.1 2161597 D 282458 CDS YP_041460.1 49484236 2860105 complement(2162247..2162387) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 8 TR:Q9MBT1 (EMBL:AB044554) (46 aa) fasta scores: E(): 3.2e-16, 95.65% id in 46 aa; hypothetical protein 2162387 2860105 SAR2094 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041460.1 2162247 R 282458 CDS YP_041461.1 49484237 2860106 complement(2162418..2162615) 1 NC_002952.2 Similar to bacteriophage phi PVL hypothetical protein Orf 35 TR:O80075 (EMBL:AB009866) (65 aa) fasta scores: E(): 8.1e-25, 95.38% id in 65 aa. Similar to SAR1552, 67.692% identity (67.692% ungapped) in 65 aa overlap; hypothetical protein 2162615 2860106 SAR2095 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041461.1 2162418 R 282458 CDS YP_041462.1 49484238 2860107 complement(2162631..2163383) 1 NC_002952.2 Similar to bacteriophage phi PVL anti repressor TR:O80074 (EMBL:AB009866) (249 aa) fasta scores: E(): 1.3e-70, 80.95% id in 252 aa, and to bacteriophage phi ETA hypothetical protein Orf11 TR:Q9G034 (EMBL:AP001553) (250 aa) fasta scores: E(): 1.6e-80, 89.6% id in 250 aa; anti repressor 2163383 2860107 SAR2096 Staphylococcus aureus subsp. aureus MRSA252 anti repressor YP_041462.1 2162631 R 282458 CDS YP_041463.1 49484239 2860108 2163434..2163763 1 NC_002952.2 Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf121 TR:Q9B0H0 (EMBL:AB045978) (121 aa) fasta scores: E(): 0.0053, 24.07% id in 108 aa; hypothetical protein 2163763 2860108 SAR2097 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041463.1 2163434 D 282458 CDS YP_041464.1 49484240 2860109 complement(2163752..2163967) 1 NC_002952.2 Poor database matches. Similar to N-terminal region of Schizosaccharomyces pombe 60S ribosomal protein L43 RPL43 SW:RL43_SCHPO (O94686) (94 aa) fasta scores: E(): 5.5, 37.5% id in 56 aa; hypothetical protein 2163967 2860109 SAR2098 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041464.1 2163752 R 282458 CDS YP_041465.1 49484241 2860110 complement(2163983..2164246) 1 NC_002952.2 Similar to bacteriophage A118 repressor protein TR:Q9T188 (EMBL:AJ242593) (101 aa) fasta scores: E(): 0.096, 37.87% id in 66 aa, and to Pyrococcus abyssi repressor protein PAB7155 TR:Q9V101 (EMBL:AJ248284) (73 aa) fasta scores: E(): 0.047, 39.06% id in 64 aa; DNA-binding protein 2164246 2860110 SAR2099 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_041465.1 2163983 R 282458 CDS YP_041466.1 49484242 2860111 2164379..2165092 1 NC_002952.2 Similar to bacteriophage phi ETA bacteriophage phi ETA repressor TR:Q9G039 (EMBL:AP001553) (238 aa) fasta scores: E(): 6.1e-57, 72.29% id in 231 aa, and to Staphylococcus aureus prophage phiPV83 repressor TR:Q9MBT4 (EMBL:AB044554) (236 aa) fasta scores: E(): 1.2e-42, 55.17% id in 232 aa; repressor 2165092 2860111 SAR2100 Staphylococcus aureus subsp. aureus MRSA252 repressor YP_041466.1 2164379 D 282458 CDS YP_041467.1 49484243 2860112 2165108..2166040 1 NC_002952.2 Similar to Caulobacter crescentus exonuclease CC1523 TR:Q9A841 (EMBL:AE005827) (202 aa) fasta scores: E(): 1.6e-13, 30.57% id in 193 aa, and to Chlamydia pneumoniae DNA polymerase III epsilon chain CP0344 TR:Q9Z8D3 (EMBL:AE001624) (237 aa) fasta scores: E(): 1.2e-05, 25.5% id in 200 aa; exonuclease 2166040 2860112 SAR2101 Staphylococcus aureus subsp. aureus MRSA252 exonuclease YP_041467.1 2165108 D 282458 CDS YP_041468.1 49484244 2860113 2166046..2166387 1 NC_002952.2 hypothetical protein 2166387 2860113 SAR2102 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041468.1 2166046 D 282458 CDS YP_041469.1 49484245 2860114 2166570..2166773 1 NC_002952.2 hypothetical protein 2166773 2860114 SAR2103 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041469.1 2166570 D 282458 CDS YP_041470.1 49484246 2860115 2166873..2167337 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf144 TR:Q9B0H6 (EMBL:AB045978) (144 aa) fasta scores: E(): 0.0021, 31.61% id in 136 aa; lipoprotein 2167337 2860115 SAR2104 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_041470.1 2166873 D 282458 CDS YP_041471.1 49484247 2859670 2167396..2168433 1 NC_002952.2 Similar to Staphylococcus aureus bacteriophage phi-42 integrase Int TR:Q38086 (EMBL:U01872) (345 aa) fasta scores: E(): 2.3e-125, 99.13% id in 345 aa, and to bacteriophage phi-13 integrase Int TR:Q38460 (EMBL:X82312) (345 aa) fasta scores: E(): 9.1e-125, 98.55% id in 345 aa; integrase 2168433 int 2859670 int Staphylococcus aureus subsp. aureus MRSA252 integrase YP_041471.1 2167396 D 282458 CDS YP_041472.1 49484248 2860116 complement(2169572..2170591) 1 NC_002952.2 Similar to Staphylococcus aureus leukocidin F subunit precursor LukF SW:LUKF_STAAU (P31715) (323 aa) fasta scores: E(): 2.5e-34, 40.97% id in 327 aa, and to Staphylococcus aureus prophage phiPV83 leukocidin F precursor LukF-PV TR:Q9MBN2 (EMBL:AB044554) (322 aa) fasta scores: E(): 4.2e-40, 39.45% id in 327 aa; leukocidin F subunit 2170591 2860116 SAR2107 Staphylococcus aureus subsp. aureus MRSA252 leukocidin F subunit YP_041472.1 2169572 R 282458 CDS YP_041473.1 49484249 2860117 complement(2170613..2171668) 1 NC_002952.2 Similar to Staphylococcus aureus leukocidin S subunit precursor LukS SW:LUKS_STAAU (P31716) (315 aa) fasta scores: E(): 1.8e-25, 33.44% id in 290 aa, and to bacteriophage phi PVL leukocidin S component LukS-PV TR:O80066 (EMBL:AB009866) (312 aa) fasta scores: E(): 6.1e-27, 34.64% id in 280 aa; leukocidin S subunit 2171668 2860117 SAR2108 Staphylococcus aureus subsp. aureus MRSA252 leukocidin S subunit YP_041473.1 2170613 R 282458 CDS YP_041474.1 49484250 2860118 2172100..2173323 1 NC_002952.2 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2173323 2860118 SAR2109 Staphylococcus aureus subsp. aureus MRSA252 succinyl-diaminopimelate desuccinylase YP_041474.1 2172100 D 282458 CDS YP_041475.1 49484251 2860119 2173762..2175069 1 NC_002952.2 Similar to Bacillus subtilis YubG TR:O32081 (EMBL:Z99119) (445 aa) fasta scores: E(): 1.1e-58, 43.02% id in 423 aa, and to Aquifex aeolicus K+ transport protein homologue AQ_1504 TR:O67474 (EMBL:AE000743) (443 aa) fasta scores: E(): 3.4e-54, 38.82% id in 443 aa; sodium transport protein 2175069 2860119 SAR2111 Staphylococcus aureus subsp. aureus MRSA252 sodium transport protein YP_041475.1 2173762 D 282458 CDS YP_041476.1 49484252 2860121 complement(2175647..2175988) 1 NC_002952.2 Doubtful CDS, poor translational start site. No significant database matches; hypothetical protein 2175988 2860121 SAR2113 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041476.1 2175647 R 282458 CDS YP_041477.1 49484253 2860122 complement(2175978..2176274) 1 NC_002952.2 Doubtful CDS, poor translational start site. No significant database matches; hypothetical protein 2176274 2860122 SAR2114 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041477.1 2175978 R 282458 CDS YP_041478.1 49484254 2860123 complement(2176271..2176459) 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Mycoplasma capricolum DNA repair protein RecM TR:Q49026 (EMBL:Z33128) (107 aa) fasta scores: E(): 9.9, 30.18% id in 53 aa; hypothetical protein 2176459 2860123 SAR2115 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041478.1 2176271 R 282458 CDS YP_041479.1 49484255 2859943 complement(2176992..2178608) 1 NC_002952.2 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 2178608 groEL 2859943 groEL Staphylococcus aureus subsp. aureus MRSA252 chaperonin GroEL YP_041479.1 2176992 R 282458 CDS YP_041480.1 49484256 2859944 complement(2178684..2178968) 1 NC_002952.2 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 2178968 groES 2859944 groES Staphylococcus aureus subsp. aureus MRSA252 co-chaperonin GroES YP_041480.1 2178684 R 282458 CDS YP_041481.1 49484257 2860124 2179143..2179886 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdiL TR:O05525 (EMBL:D88802) (244 aa) fasta scores: E(): 2.4e-18, 33.33% id in 240 aa, and to Bacillus halodurans hypothetical protein BH0560 TR:Q9KFC4 (EMBL:AP001508) (237 aa) fasta scores: E(): 1.8e-16, 32.74% id in 226 aa; hypothetical protein 2179886 2860124 SAR2118 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041481.1 2179143 D 282458 CDS YP_041482.1 49484258 2860125 complement(2179911..2181125) 1 NC_002952.2 Poor database matches. Similar to Staphylococcus epidermidis cell-surface-associated protein SdrH TR:Q9KI12 (EMBL:AF245043) (487 aa) fasta scores: E(): 1.1e-20, 32.51% id in 366 aa. Contains a proline rich region, residues 106 to 182; membrane anchored protein 2181125 2860125 SAR2119 Staphylococcus aureus subsp. aureus MRSA252 membrane anchored protein YP_041482.1 2179911 R 282458 CDS YP_041483.1 49484259 2860126 2181322..2181948 1 NC_002952.2 Similar to Neisseria meningitidis (serogroup A) hypothetical protein NMA2195 TR:Q9JQW5 (EMBL:AL162758) (201 aa) fasta scores: E(): 1.6e-34, 49.74% id in 195 aa, and to Pseudomonas aeruginosa hypothetical protein PA2575 TR:Q9I0R1 (EMBL:AE004686) (200 aa) fasta scores: E(): 4.4e-32, 46.9% id in 194 aa; hypothetical protein 2181948 2860126 SAR2120 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041483.1 2181322 D 282458 CDS YP_041484.1 49484260 2860541 2182309..2183094 1 NC_002952.2 Previously sequenced as Staphylococcus aureus hypothetical protein in agr operon SW:YAG5_STAAU (P55177) (261 aa) fasta scores: E(): 3.9e-101, 98.85% id in 261 aa. Similar to Staphylococcus epidermidis hypothetical protein TR:O68163 (EMBL:AF012132) (264 aa) fasta scores: E(): 3.5e-61, 61.3% id in 261 aa; carbon-nitrogen hydrolase 2183094 2860541 SAR2121 Staphylococcus aureus subsp. aureus MRSA252 carbon-nitrogen hydrolase YP_041484.1 2182309 D 282458 CDS YP_041485.1 49484261 2861641 complement(2183697..2183834) 1 NC_002952.2 Lyses erythrocytes and other mammalian cells; delta-hemolysin 2183834 hld 2861641 hld Staphylococcus aureus subsp. aureus MRSA252 delta-hemolysin YP_041485.1 2183697 R 282458 CDS YP_041486.1 49484262 2860982 2184067..2184630 1 NC_002952.2 Signal generating component of the agr autoinducer peptide-quorum sensing system. Similar to Staphylococcus aureus probable autoinducer processing protein, accessory gene regulator protein B, AgrB SW:AGRB_STAAU (P21545) (189 aa) fasta scores: E(): 8.9e-56, 77.54% id in 187 aa, and to Staphylococcus epidermidis accessory gene regulator protein AgrB TR:O86859 (EMBL:Z49220) (194 aa) fasta scores: E(): 9.9e-36, 51.87% id in 187 aa; autoinducer processing protein 2184630 agrB 2860982 agrB Staphylococcus aureus subsp. aureus MRSA252 autoinducer processing protein YP_041486.1 2184067 D 282458 CDS YP_041487.1 49484263 2860984 2184634..2184774 1 NC_002952.2 Signal generating component of the agr autoinducer peptide-quorum sensing system. Similar to Staphylococcus aureus group III autoinducer peptide precursor AgrD TR:O33589 (EMBL:AF001783) (46 aa) fasta scores: E(): 6.7e-19, 100% id in 46 aa. Similar to Staphylococcus aureus group IV autoinducer peptide precursor AgrD TR:Q9L561 (EMBL:AF255950) (46 aa) fasta scores: E(): 1.7e-06, 47.82% id in 46 aa; autoinducer peptide 2184774 agrD 2860984 agrD Staphylococcus aureus subsp. aureus MRSA252 autoinducer peptide YP_041487.1 2184634 D 282458 CDS YP_041488.1 49484264 2860983 2184799..2186091 1 NC_002952.2 Signal dectecting component of the agr autoinducer peptide-quorum sensing system. Two-component regulatory system family, sensor kinase. Similar to Staphylococcus aureus accessory gene regulator C AgrC TR:Q53644 (EMBL:X52543) (423 aa) fasta scores: E(): 1.7e-101, 75.23% id in 424 aa, and to Staphylococcus epidermidis histidine kinase AgrC TR:O68159 (EMBL:AF012132) (429 aa) fasta scores: E(): 6.3e-76, 54.93% id in 426 aa; autoinducer sensor protein 2186091 agrC 2860983 agrC Staphylococcus aureus subsp. aureus MRSA252 autoinducer sensor protein YP_041488.1 2184799 D 282458 CDS YP_041489.1 49484265 2860981 2186110..2186826 1 NC_002952.2 Signal dectecting component of the agr autoinducer peptide-quorum sensing system. Two-component regulatory system family, response regulator protein. Identical to Staphylococcus aureus accessory gene regulator protein A AgrA SW:AGRA_STAAU (P13131) (238 aa) fasta scores: E(): 2.5e-94, 100% id in 238 aa. Similar to Staphylococcus epidermidis response regulator AgrA TR:O68158 (EMBL:AF012132) (238 aa) fasta scores: E(): 2.2e-84, 87.39% id in 238 aa; autoinducer sensor protein response regulator protein 2186826 agrA 2860981 agrA Staphylococcus aureus subsp. aureus MRSA252 autoinducer sensor protein response regulator protein YP_041489.1 2186110 D 282458 CDS YP_041490.1 49484266 2859373 complement(2187200..2188159) 1 NC_002952.2 Similar to Lycopersicon esculentum fructokinase FRK2 TR:Q42896 (EMBL:U62329) (328 aa) fasta scores: E(): 2.5e-39, 39.49% id in 314 aa, and to Beta vulgaris fructokinase TR:Q42645 (EMBL:U37838) (331 aa) fasta scores: E(): 3.3e-39, 40.38% id in 312 aa; fructokinase 2188159 2859373 SAR2127 Staphylococcus aureus subsp. aureus MRSA252 fructokinase YP_041490.1 2187200 R 282458 CDS YP_041491.1 49484267 2859127 complement(2188156..2189640) 1 NC_002952.2 Similar to Staphylococcus xylosus sucrose-6-phosphate hydrolase ScrB SW:SCRB_STAXY (Q05936) (494 aa) fasta scores: E(): 9e-151, 70.12% id in 492 aa, and to Vibrio alginolyticus sucrose-6-phosphate hydrolase ScrB SW:SCRB_VIBAL (P13394) (484 aa) fasta scores: E(): 1.8e-65, 39.87% id in 469 aa; sucrose-6-phosphate hydrolase 2189640 scrB 2859127 scrB Staphylococcus aureus subsp. aureus MRSA252 sucrose-6-phosphate hydrolase YP_041491.1 2188156 R 282458 CDS YP_041492.1 49484268 2859128 complement(2189789..2190739) 1 NC_002952.2 Similar to Staphylococcus xylosus sucrose operon repressor ScrR SW:SCRR_STAXY (P74892) (320 aa) fasta scores: E(): 1.6e-67, 59.23% id in 314 aa, and to Bacillus halodurans transcriptional regulator BH1855 TR:Q9KBS0 (EMBL:AP001513) (326 aa) fasta scores: E(): 1.2e-38, 37.1% id in 318 aa; sucrose operon repressor 2190739 scrR 2859128 scrR Staphylococcus aureus subsp. aureus MRSA252 sucrose operon repressor YP_041492.1 2189789 R 282458 CDS YP_041493.1 49484269 2859374 complement(2190923..2192173) 1 NC_002952.2 Similar to Bacillus subtilis probable ammonium transporter NrgA SW:NRGA_BACSU (Q07429) (404 aa) fasta scores: E(): 2.8e-79, 51.49% id in 402 aa, and to Lactococcus lactis ammonium transporter AmtB TR:Q9CF89 (EMBL:AE006389) (413 aa) fasta scores: E(): 7.4e-60, 42.01% id in 407 aa; ammonium transporter family protein 2192173 2859374 SAR2130 Staphylococcus aureus subsp. aureus MRSA252 ammonium transporter family protein YP_041493.1 2190923 R 282458 CDS YP_041494.1 49484270 2859375 complement(2192382..2192606) 1 NC_002952.2 Similar to Escherichia coli hypothetical protein YeeD SW:YEED_ECOLI (P33014) (75 aa) fasta scores: E(): 3.3e-17, 63.01% id in 73 aa, and to Escherichia coli, hypothetical protein YedF SW:YEDF_ECOLI (P31065) (77 aa) fasta scores: E(): 0.00059, 32.39% id in 71 aa; hypothetical protein 2192606 2859375 SAR2131 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041494.1 2192382 R 282458 CDS YP_041495.1 49484271 2859376 complement(2192666..2193745) 1 NC_002952.2 Similar to Escherichia coli hypothetical protein YeeE SW:YEEE_ECOLI (P33015) (352 aa) fasta scores: E(): 1.2e-78, 58.62% id in 348 aa, and to Thermotoga maritima conserved hypothetical protein YM0982 TR:Q9X077 (EMBL:AE001760) (332 aa) fasta scores: E(): 3.3e-28, 35.65% id in 345 aa; hypothetical protein 2193745 2859376 SAR2132 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041495.1 2192666 R 282458 CDS YP_041496.1 49484272 2859377 complement(2194051..2194686) 1 NC_002952.2 modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 2194686 2859377 SAR2133 Staphylococcus aureus subsp. aureus MRSA252 redox-sensing transcriptional repressor Rex YP_041496.1 2194051 R 282458 CDS YP_041497.1 49484273 2859378 2194939..2196867 1 NC_002952.2 Similar to Bacillus subtilis hypothetical ABC transporter ATP-binding protein YdiF SW:YDIF_BACSU (O05519) (642 aa) fasta scores: E(): 4.3e-84, 48.36% id in 641 aa, and to Bacillus halodurans ABC transporter BH0550 TR:Q9KFD1 (EMBL:AP001508) (642 aa) fasta scores: E(): 1.3e-80, 45.25% id in 643 aa; ABC transporter ATP-binding protein 2196867 2859378 SAR2134 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041497.1 2194939 D 282458 CDS YP_041498.1 49484274 2859075 2197235..2198845 1 NC_002952.2 No significant database matches to the full length CDS. C-terminal region is similar to internal regions of Thermus aquaticus DNA mismatch repair protein MutS SW:MUTS_THEAQ (Q56215) (811 aa) fasta scores: E(): 6.8e-13, 25.96% id in 312 aa, and Streptococcus pyogenes DNA mismatch repair protein SPY2148 TR:Q99XL8 (EMBL:AE006633) (851 aa) fasta scores: E(): 1e-14, 28.83% id in 274 aa; hypothetical protein 2198845 2859075 SAR2135 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041498.1 2197235 D 282458 CDS YP_041499.1 49484275 2859076 complement(2199159..2200184) 1 NC_002952.2 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 2200184 2859076 SAR2136 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding/iron metalloprotein/AP endonuclease YP_041499.1 2199159 R 282458 CDS YP_041500.1 49484276 2859077 complement(2200177..2200641) 1 NC_002952.2 Similar to Escherichia coli ribosomal-protein-alanine acetyltransferase RimI SW:RIMI_ECOLI (P09453) (148 aa) fasta scores: E(): 2e-07, 29.86% id in 144 aa, and to Bacillus subtilis hypothetical protein YdiD TR:O05517 (EMBL:D88802) (151 aa) fasta scores: E(): 6.2e-24, 45.69% id in 151 aa; acetyltransferase 2200641 2859077 SAR2137 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_041500.1 2200177 R 282458 CDS YP_041501.1 49484277 2859078 complement(2200614..2201276) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdiC TR:O05516 (EMBL:D88802) (229 aa) fasta scores: E(): 2.6e-25, 43.91% id in 230 aa, and to Enterococcus faecalis hypothetical protein YdiC TR:O86212 (EMBL:Y17797) (204 aa) fasta scores: E(): 1.2e-23, 44.11% id in 204 aa. Possible alternative translational start site; hypothetical protein 2201276 2859078 SAR2138 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041501.1 2200614 R 282458 CDS YP_041502.1 49484278 2859079 complement(2201257..2201751) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0545 TR:Q9KFD6 (EMBL:AP001508) (157 aa) fasta scores: E(): 7.7e-21, 47.82% id in 138 aa, and to Bacillus subtilis hypothetical protein YdiB SW:YDIB_BACSU (O05515) (158 aa) fasta scores: E(): 2.6e-18, 43.26% id in 141 aa; hypothetical protein 2201751 2859079 SAR2139 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041502.1 2201257 R 282458 CDS YP_041503.1 49484279 2859665 2202229..2203917 1 NC_002952.2 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 2203917 ilvD 2859665 ilvD Staphylococcus aureus subsp. aureus MRSA252 dihydroxy-acid dehydratase YP_041503.1 2202229 D 282458 CDS YP_041504.1 49484280 2859663 2203945..2205714 1 NC_002952.2 Similar to Lactococcus lactis acetolactate synthase large subunit IlvB SW:ILVB_LACLA (Q02137) (575 aa) fasta scores: E(): 5e-115, 53.95% id in 556 aa, and to Bacillus subtilis acetolactate synthase large subunit IlvB SW:ILVB_BACSU (P37251) (573 aa) fasta scores: E(): 1.5e-119, 54.15% id in 554 aa; acetolactate synthase large subunit 2205714 ilvB 2859663 ilvB Staphylococcus aureus subsp. aureus MRSA252 acetolactate synthase large subunit YP_041504.1 2203945 D 282458 CDS YP_041505.1 49484281 2859664 2206105..2207109 1 NC_002952.2 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 2207109 ilvC 2859664 ilvC Staphylococcus aureus subsp. aureus MRSA252 ketol-acid reductoisomerase YP_041505.1 2206105 D 282458 CDS YP_041506.1 49484282 2859698 2207139..2208668 1 NC_002952.2 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 2208668 leuA 2859698 leuA Staphylococcus aureus subsp. aureus MRSA252 2-isopropylmalate synthase YP_041506.1 2207139 D 282458 CDS YP_041507.1 49484283 2859699 2208671..2209717 1 NC_002952.2 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 2209717 leuB 2859699 leuB Staphylococcus aureus subsp. aureus MRSA252 3-isopropylmalate dehydrogenase YP_041507.1 2208671 D 282458 CDS YP_041508.1 49484284 2859700 2209731..2211098 1 NC_002952.2 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 2211098 leuC 2859700 leuC Staphylococcus aureus subsp. aureus MRSA252 isopropylmalate isomerase large subunit YP_041508.1 2209731 D 282458 CDS YP_041509.1 49484285 2859701 2211099..2211671 1 NC_002952.2 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 2211671 leuD 2859701 leuD Staphylococcus aureus subsp. aureus MRSA252 isopropylmalate isomerase small subunit YP_041509.1 2211099 D 282458 CDS YP_041510.1 49484286 2859662 2211686..2212954 1 NC_002952.2 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 2212954 ilvA 2859662 ilvA Staphylococcus aureus subsp. aureus MRSA252 threonine dehydratase YP_041510.1 2211686 D 282458 CDS YP_041511.1 49484287 2859080 complement(2213031..2213447) 1 NC_002952.2 hypothetical protein 2213447 2859080 SAR2149 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041511.1 2213031 R 282458 CDS YP_041512.1 49484288 2859081 complement(2219748..2220203) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0532 TR:Q9JWQ2 (EMBL:AP001508) (151 aa) fasta scores: E(): 3.5e-30, 53.06% id in 147 aa, and to Bacillus subtilis hypothetical protein YdcK TR:P96628 (EMBL:AB001488) (150 aa) fasta scores: E(): 2.1e-29, 50% id in 146 aa; hypothetical protein 2220203 2859081 SAR2150 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041512.1 2219748 R 282458 CDS YP_041513.1 49484289 2859082 complement(2220196..2222346) 1 NC_002952.2 Similar to Bacillus halodurans hypotetical protein BH0531 TR:Q9KFE8 (EMBL:AP001508) (728 aa) fasta scores: E(): 8.4e-135, 55.29% id in 718 aa, and to Lactococcus lactis hypotetical protein YciC TR:Q9CIS1 (EMBL:AE006266) (712 aa) fasta scores: E(): 2.4e-123, 51.87% id in 719 aa; RNA binding protein 2222346 2859082 SAR2151 Staphylococcus aureus subsp. aureus MRSA252 RNA binding protein YP_041513.1 2220196 R 282458 CDS YP_041514.1 49484290 2859143 complement(2222781..2223551) 1 NC_002952.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase; RNA polymerase sigma factor SigB 2223551 sigB 2859143 sigB Staphylococcus aureus subsp. aureus MRSA252 RNA polymerase sigma factor SigB YP_041514.1 2222781 R 282458 CDS YP_041515.1 49484291 2861460 complement(2223526..2224005) 1 NC_002952.2 binds to sigma-B preventing the formation of an RNA polymerase holoenzyme; serine-protein kinase RsbW 2224005 rsbW 2861460 rsbW Staphylococcus aureus subsp. aureus MRSA252 serine-protein kinase RsbW YP_041515.1 2223526 R 282458 CDS YP_041516.1 49484292 2861459 complement(2224007..2224333) 1 NC_002952.2 Similar to Bacillus subtilis anti-sigma B factor antagonist RsbV SW:RSBV_BACSU (P17903) (109 aa) fasta scores: E(): 4.7e-14, 42.45% id in 106 aa. Previously sequenced as Staphylococcus aureus anti-sigma B factor antagonist RsbV SW:RSBV_STAAU (P95842) (108 aa) fasta scores: E(): 2.1e-39, 99.07% id in 108 aa; anti-sigma B factor antagonist 2224333 rsbV 2861459 rsbV Staphylococcus aureus subsp. aureus MRSA252 anti-sigma B factor antagonist YP_041516.1 2224007 R 282458 CDS YP_041517.1 49484293 2861458 complement(2224452..2225453) 1 NC_002952.2 Similar to Bacillus subtilis sigma factor SigB regulation protein, required for full glucose induction of sigma B-dependent genes, RsbU SW:RSBU_BACSU (P40399) (335 aa) fasta scores: E(): 1.5e-41, 38.85% id in 332 aa, and to Bacillus halodurans indirect positive regulator of sigma-B activity BH0526 TR:Q9KFF3 (EMBL:AP001508) (337 aa) fasta scores: E(): 5.1e-45, 39.58% id in 336 aa; sigma factor sigB regulation protein 2225453 rsbU 2861458 rsbU Staphylococcus aureus subsp. aureus MRSA252 sigma factor sigB regulation protein YP_041517.1 2224452 R 282458 CDS YP_041518.1 49484294 2859083 complement(2225802..2226164) 1 NC_002952.2 Similar to Escherichia coli protein responsible for the stable inheritance of plasmids during cell division, PemK SW:PEMK_ECOLI (P13976) (133 aa) fasta scores: E(): 0.019, 28.43% id in 102 aa, and to Staphylococcus epidermidis hypothetical protein TR:Q9F7V5 (EMBL:AF274004) (120 aa) fasta scores: E(): 3.3e-35, 90% id in 120 aa; hypothetical protein 2226164 2859083 SAR2156 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041518.1 2225802 R 282458 CDS YP_041519.1 49484295 2859084 complement(2226161..2226331) 1 NC_002952.2 Similar to the C-terminal regions of Lactobacillus reuteri hypothetical protein TR:Q9FCV1 (EMBL:AJ278312) (82 aa) fasta scores: E(): 4.5, 33.84% id in 65 aa, and Bacillus subtilis hypothetical protein YdcD TR:P96621 (EMBL:AB001488) (93 aa) fasta scores: E(): 2.1, 40% id in 35 aa; hypothetical protein 2226331 2859084 SAR2157 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041519.1 2226161 R 282458 CDS YP_041520.1 49484296 2860990 complement(2226416..2227564) 1 NC_002952.2 Similar to Bacillus stearothermophilus alanine racemase Alr SW:ALR_BACST (P10724) (388 aa) fasta scores: E(): 4.4e-53, 43.66% id in 371 aa. Previously sequenced as Staphylococcus aureus alanine racemase Alr SW:ALR_STAAU (Q9ZAH5) (382 aa) fasta scores: E(): 1e-147, 99.47% id in 382 aa; alanine racemase 2227564 alr 2860990 alr Staphylococcus aureus subsp. aureus MRSA252 alanine racemase YP_041520.1 2226416 R 282458 CDS YP_041521.1 49484297 2859058 complement(2227630..2227989) 1 NC_002952.2 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2227989 acpS 2859058 acpS Staphylococcus aureus subsp. aureus MRSA252 4'-phosphopantetheinyl transferase YP_041521.1 2227630 R 282458 CDS YP_041522.1 49484298 2859085 complement(2227993..2228484) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdbS TR:P96615 (EMBL:AB001488) (159 aa) fasta scores: E(): 1.2e-08, 30.98% id in 142 aa, and to Bacillus halodurans hypothetical protein BH1720 TR:Q9KC54 (EMBL:AP001512) (159 aa) fasta scores: E(): 3.6e-05, 25% id in 148 aa; hypothetical protein 2228484 2859085 SAR2160 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041522.1 2227993 R 282458 CDS YP_041523.1 49484299 2859086 complement(2228477..2230054) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdbT TR:P96616 (EMBL:AB001488) (493 aa) fasta scores: E(): 7.6e-12, 22.64% id in 530 aa, and to Bacillus halodurans hypothetical protein BH1721 TR:Q9KC53 (EMBL:AP001512) (496 aa) fasta scores: E(): 2e-08, 21.46% id in 531 aa; hypothetical protein 2230054 2859086 SAR2161 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041523.1 2228477 R 282458 CDS YP_041524.1 49484300 2859087 complement(2230047..2230526) 1 NC_002952.2 Similar to Bacillus halodurans Bhypothetical protein H1720 TR:Q9KC54 (EMBL:AP001512) (159 aa) fasta scores: E(): 0.14, 23.3% id in 133 aa, and to Bacillus subtilis hypothetical protein YdbS TR:P96615 (EMBL:AB001488) (159 aa) fasta scores: E(): 0.3, 20.98% id in 162 aa; hypothetical protein 2230526 2859087 SAR2162 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041524.1 2230047 R 282458 CDS YP_041525.1 49484301 2859682 complement(2230735..2231295) 1 NC_002952.2 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 2231295 kdpC 2859682 kdpC Staphylococcus aureus subsp. aureus MRSA252 potassium-transporting ATPase subunit C YP_041525.1 2230735 R 282458 CDS YP_041526.1 49484302 2859681 complement(2231315..2233342) 1 NC_002952.2 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 2233342 kdpB 2859681 kdpB Staphylococcus aureus subsp. aureus MRSA252 potassium-transporting ATPase subunit B YP_041526.1 2231315 R 282458 CDS YP_041527.1 49484303 2859680 complement(2233361..2235037) 1 NC_002952.2 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 2235037 kdpA 2859680 kdpA Staphylococcus aureus subsp. aureus MRSA252 potassium-transporting ATPase subunit A YP_041527.1 2233361 R 282458 CDS YP_041528.1 49484304 2859683 2235309..2237966 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Similar to Escherichia coli sensor for high-affinity potassium transport system KdpD SW:KDPD_ECOLI (P21865) (894 aa) fasta scores: E(): 4.1e-61, 26.59% id in 876 aa, and to Rhizobium loti two-component sensor MLL3127 TR:BAB50088 (EMBL:AP003001) (907 aa) fasta scores: E(): 2.4e-67, 27.54% id in 875 aa; sensor kinase 2237966 kdpD 2859683 kdpD Staphylococcus aureus subsp. aureus MRSA252 sensor kinase YP_041528.1 2235309 D 282458 CDS YP_041529.1 49484305 2859685 2237966..2238661 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Similar to Escherichia coli kdp operon transcriptional regulatory protein KdpE SW:KDPE_ECOLI (P21866) (225 aa) fasta scores: E(): 5.9e-26, 40.26% id in 226 aa, and to Clostridium acetobutylicum CAC3677 TR:P94609 (EMBL:U39673) (232 aa) fasta scores: E(): 1.1e-26, 39.11% id in 225 aa; response regulator protein 2238661 kdpE 2859685 kdpE Staphylococcus aureus subsp. aureus MRSA252 response regulator protein YP_041529.1 2237966 D 282458 CDS YP_041530.1 49484306 2859088 complement(2239017..2240537) 1 NC_002952.2 Similar to the N-terminal region of Escherichia coli cold-shock DEAD-box protein A CsdA SW:DEAD_ECOLI (P23304) (628 aa) fasta scores: E(): 1.2e-55, 40.8% id in 473 aa, and to Bacillus subtilis ATP-dependent RNA helicase YdbR TR:P96614 (EMBL:AB001488) (511 aa) fasta scores: E(): 3.3e-79, 47.35% id in 492 aa; helicase 2240537 2859088 SAR2168 Staphylococcus aureus subsp. aureus MRSA252 helicase YP_041530.1 2239017 R 282458 CDS YP_041531.1 49484307 2859089 complement(2241054..2242412) 1 NC_002952.2 Similar to Escherichia coli UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate --D-alanyl-D- alanyl ligase MurF SW:MURF_ECOLI (P11880) (452 aa) fasta scores: E(): 4.4e-38, 32.23% id in 456 aa, and to Bacillus subtilis UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate --D-alanyl-D- alanyl ligase MurF SW:MURF_BACSU (P96613) (457 aa) fasta scores: E(): 1e-68, 45.51% id in 457 aa; UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-- D-alanyl-D-alanyl ligase 2242412 2859089 SAR2169 Staphylococcus aureus subsp. aureus MRSA252 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-- D-alanyl-D-alanyl ligase YP_041531.1 2241054 R 282458 CDS YP_041532.1 49484308 2859090 complement(2242427..2243497) 1 NC_002952.2 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 2243497 ddl 2859090 ddl Staphylococcus aureus subsp. aureus MRSA252 D-alanyl-alanine synthetase A YP_041532.1 2242427 R 282458 CDS YP_041533.1 49484309 2859091 2243815..2245017 1 NC_002952.2 Similar to Escherichia coli rod shape-determining protein RodA SW:RODA_ECOLI (P15035) (370 aa) fasta scores: E(): 4.6e-25, 33.59% id in 387 aa, and to Bacillus subtilis hypothetical protein YwcF SW:YWCF_BACSU (P39604) (393 aa) fasta scores: E(): 9e-46, 37.78% id in 397 aa; hypothetical protein 2245017 2859091 SAR2171 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041533.1 2243815 D 282458 CDS YP_041534.1 49484310 2859093 complement(2246273..2246410) 1 NC_002952.2 hypothetical protein 2246410 2859093 SAR2173 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041534.1 2246273 R 282458 CDS YP_041535.1 49484311 2859094 complement(2246538..2246747) 1 NC_002952.2 Similar to Helicobacter felis divalent cation binding protein CopP SW:COPP_HELFE (O32620) (66 aa) fasta scores: E(): 1, 24.59% id in 61 aa, and to Bacillus halodurans mercuric transporter BH0556 TR:Q9KFC8 (EMBL:AP001508) (67 aa) fasta scores: E(): 0.17, 26.15% id in 65 aa; hypothetical protein 2246747 2859094 SAR2174 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041535.1 2246538 R 282458 CDS YP_041536.1 49484312 2859096 2247217..2248701 1 NC_002952.2 Similar to Bacillus firmus cardiolipin synthetase Cls SW:CLS_BACFI (O66043) (503 aa) fasta scores: E(): 3.7e-71, 42.77% id in 498 aa, and to Bacillus subtilis probable cardiolipin synthetase 2 YwnE SW:CLS2_BACSU (P71040) (482 aa) fasta scores: E(): 3.9e-108, 58% id in 481 aa; cardiolipin synthetase 2248701 2859096 SAR2177 Staphylococcus aureus subsp. aureus MRSA252 cardiolipin synthetase YP_041536.1 2247217 D 282458 CDS YP_041537.1 49484313 2859097 2248729..2249376 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2835 TR:Q9K916 (EMBL:AP001516) (215 aa) fasta scores: E(): 8.6e-28, 37.5% id in 216 aa, and to Lactococcus lactis hypothetical protein YagB TR:Q9CJD2 (EMBL:AE006245) (216 aa) fasta scores: E(): 5.7e-20, 36.09% id in 205 aa; hypothetical protein 2249376 2859097 SAR2178 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041537.1 2248729 D 282458 CDS YP_041538.1 49484314 2859098 complement(2249989..2250861) 1 NC_002952.2 Similar to Bacillus subtilis stage III sporulation protein J precursor SpoIIIJ SW:SP3J_BACSU (Q01625) (261 aa) fasta scores: E(): 3.6e-15, 34.12% id in 252 aa, and to Bacillus halodurans stage III sporulation protein J BH1169 TR:Q9KDP2 (EMBL:AP001511) (280 aa) fasta scores: E(): 1.6e-26, 36.33% id in 289 aa; hypothetical protein 2250861 2859098 SAR2179 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041538.1 2249989 R 282458 CDS YP_041539.1 49484315 2859526 complement(2250947..2251588) 1 NC_002952.2 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 2251588 thiE 2859526 thiE Staphylococcus aureus subsp. aureus MRSA252 thiamine-phosphate pyrophosphorylase YP_041539.1 2250947 R 282458 CDS YP_041540.1 49484316 2859528 complement(2251590..2252381) 1 NC_002952.2 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2252381 thiM 2859528 thiM Staphylococcus aureus subsp. aureus MRSA252 hydroxyethylthiazole kinase YP_041540.1 2251590 R 282458 CDS YP_041541.1 49484317 2859525 complement(2252365..2253195) 1 NC_002952.2 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2253195 thiD 2859525 thiD Staphylococcus aureus subsp. aureus MRSA252 phosphomethylpyrimidine kinase YP_041541.1 2252365 R 282458 CDS YP_041542.1 49484318 2859523 complement(2253188..2253877) 1 NC_002952.2 Similar to Bacillus subtilis transcriptional activator of extracellular enzyme genes TenA SW:TENA_BACSU (P25052) (236 aa) fasta scores: E(): 3.9e-07, 23.11% id in 225 aa, and to Staphylococcus carnosus possible transcriptional activator TenA TR:O54496 (EMBL:AF109218) (228 aa) fasta scores: E(): 3.2e-51, 55.75% id in 226 aa; transcriptional activator 2253877 tenA 2859523 tenA Staphylococcus aureus subsp. aureus MRSA252 transcriptional activator YP_041542.1 2253188 R 282458 CDS YP_041543.1 49484319 2859099 2254140..2254412 1 NC_002952.2 Doubtful CDS. No database matches; hypothetical protein 2254412 2859099 SAR2183b Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041543.1 2254140 D 282458 CDS YP_041544.1 49484320 2859100 complement(2254402..2255097) 1 NC_002952.2 Similar to Staphylococcus carnosus hypothetical protein SceD TR:O54493 (EMBL:AF109218) (232 aa) fasta scores: E(): 2.4e-32, 50.82% id in 242 aa, and to Staphylococcus aureus immunodominant antigen A protein IsaA TR:Q9LAB6 (EMBL:AF144681) (233 aa) fasta scores: E(): 7.3e-13, 34.41% id in 247 aa; hypothetical protein 2255097 2859100 SAR2184 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041544.1 2254402 R 282458 CDS YP_041545.1 49484321 2859101 complement(2255486..2255881) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 single strand DNA binding protein TR:Q9MBS1 (EMBL:AB044554) (142 aa) fasta scores: E(): 5.1e-13, 38.73% id in 111 aa, and to Staphylococcus carnosus single-strand binding protein Ssb TR:O54492 (EMBL:AF109218) (145 aa) fasta scores: E(): 1.6e-22, 54.41% id in 136 aa; ssDNA-binding protein 2255881 2859101 SAR2185 Staphylococcus aureus subsp. aureus MRSA252 ssDNA-binding protein YP_041545.1 2255486 R 282458 CDS YP_041546.1 49484322 2859102 2256075..2256515 1 NC_002952.2 Similar to Staphylococcus carnosus hypothetical protein TR:O54491 (EMBL:AF109218) (149 aa) fasta scores: E(): 2.4e-39, 71.81% id in 149 aa, and to Bacillus subtilis hypothetical protein YwpF TR:P94588 (EMBL:Z83337) (136 aa) fasta scores: E(): 8.1e-11, 32.35% id in 136 aa; hypothetical protein 2256515 2859102 SAR2186 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041546.1 2256075 D 282458 CDS YP_041547.1 49484323 2859622 complement(2256572..2257012) 1 NC_002952.2 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 2257012 fabZ 2859622 fabZ Staphylococcus aureus subsp. aureus MRSA252 (3R)-hydroxymyristoyl-ACP dehydratase YP_041547.1 2256572 R 282458 CDS YP_041548.1 49484324 2861318 complement(2257046..2258311) 1 NC_002952.2 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2258311 murA1 2861318 murA1 Staphylococcus aureus subsp. aureus MRSA252 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_041548.1 2257046 R 282458 CDS YP_041549.1 49484325 2861000 complement(2258422..2258655) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwzB TR:O32278 (EMBL:Z99122) (76 aa) fasta scores: E(): 2.7e-11, 44% id in 75 aa, and to Bacillus halodurans hypothetical protein BH3751 TR:Q9K6H8 (EMBL:AP001519) (77 aa) fasta scores: E(): 2.5e-08, 40% id in 75 aa; hypothetical protein 2258655 2861000 SAR2189 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041549.1 2258422 R 282458 CDS YP_041550.1 49484326 2859876 complement(2259534..2259938) 1 NC_002952.2 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 2259938 atpC 2859876 atpC Staphylococcus aureus subsp. aureus MRSA252 F0F1 ATP synthase subunit epsilon YP_041550.1 2259534 R 282458 CDS YP_041551.1 49484327 2859877 complement(2259958..2261370) 1 NC_002952.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 2261370 atpD 2859877 atpD Staphylococcus aureus subsp. aureus MRSA252 F0F1 ATP synthase subunit beta YP_041551.1 2259958 R 282458 CDS YP_041552.1 49484328 2859880 complement(2261392..2262258) 1 NC_002952.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 2262258 atpG 2859880 atpG Staphylococcus aureus subsp. aureus MRSA252 F0F1 ATP synthase subunit gamma YP_041552.1 2261392 R 282458 CDS YP_041553.1 49484329 2859874 complement(2262289..2263797) 1 NC_002952.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 2263797 atpA 2859874 atpA Staphylococcus aureus subsp. aureus MRSA252 F0F1 ATP synthase subunit alpha YP_041553.1 2262289 R 282458 CDS YP_041554.1 49484330 2859881 complement(2263819..2264358) 1 NC_002952.2 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 2264358 atpH 2859881 atpH Staphylococcus aureus subsp. aureus MRSA252 F0F1 ATP synthase subunit delta YP_041554.1 2263819 R 282458 CDS YP_041555.1 49484331 2859879 complement(2264358..2264879) 1 NC_002952.2 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel; F0F1 ATP synthase subunit B 2264879 atpF 2859879 atpF Staphylococcus aureus subsp. aureus MRSA252 F0F1 ATP synthase subunit B YP_041555.1 2264358 R 282458 CDS YP_041556.1 49484332 2859878 complement(2265078..2265290) 1 NC_002952.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 2265290 atpE 2859878 atpE Staphylococcus aureus subsp. aureus MRSA252 F0F1 ATP synthase subunit C YP_041556.1 2265078 R 282458 CDS YP_041557.1 49484333 2859875 complement(2265333..2266061) 1 NC_002952.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 2266061 atpB 2859875 atpB Staphylococcus aureus subsp. aureus MRSA252 F0F1 ATP synthase subunit A YP_041557.1 2265333 R 282458 CDS YP_041558.1 49484334 2859882 complement(2266082..2266435) 1 NC_002952.2 Similar to Bacillus subtilis ATP synthase I AtpI SW:ATPZ_BACSU (P37816) (127 aa) fasta scores: E(): 0.047, 24.34% id in 115 aa, and to Bacillus megaterium ATP synthase I AtpI SW:ATPZ_BACME (P20598) (123 aa) fasta scores: E(): 0.0046, 29.91% id in 117 aa; ATP synthase I 2266435 atpI 2859882 atpI Staphylococcus aureus subsp. aureus MRSA252 ATP synthase I YP_041558.1 2266082 R 282458 CDS YP_041559.1 49484335 2861165 complement(2266598..2267731) 1 NC_002952.2 Similar to Staphylococcus aureus UDP-GlcNAc 2-epimerase MnaA TR:Q9REV4 (EMBL:AF209197) (375 aa) fasta scores: E(): 2.9e-135, 96.53% id in 375 aa, and to Bacillus subtilis UDP-N-acetylglucosamine 2-epimerase YvyH SW:YVYH_BACSU (P39131) (380 aa) fasta scores: E(): 2.5e-87, 61.39% id in 373 aa; UDP-GlcNAc 2-epimerase 2267731 mnaA 2861165 mnaA Staphylococcus aureus subsp. aureus MRSA252 UDP-GlcNAc 2-epimerase YP_041559.1 2266598 R 282458 CDS YP_041560.1 49484336 2860414 complement(2267752..2268381) 1 NC_002952.2 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2268381 upp 2860414 upp Staphylococcus aureus subsp. aureus MRSA252 uracil phosphoribosyltransferase YP_041560.1 2267752 R 282458 CDS YP_041561.1 49484337 2859934 complement(2268409..2269647) 1 NC_002952.2 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2269647 glyA 2859934 glyA Staphylococcus aureus subsp. aureus MRSA252 serine hydroxymethyltransferase YP_041561.1 2268409 R 282458 CDS YP_041562.1 49484338 2861001 complement(2269674..2270198) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwlG SW:YWLG_BACSU (P39157) (180 aa) fasta scores: E(): 6.3e-28, 47.61% id in 168 aa, and to Bacillus halodurans hypothetical protein BH3766 TR:Q9K6G3 (EMBL:AP001519) (188 aa) fasta scores: E(): 1.4e-27, 47.39% id in 173 aa; hypothetical protein 2270198 2861001 SAR2202 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041562.1 2269674 R 282458 CDS YP_041563.1 49484339 2861002 complement(2270305..2270724) 1 NC_002952.2 Similar to Bacillus subtilis low molecular weight protein-tyrosine-phosphatase YwlE SW:YWLE_BACSU (P39155) (150 aa) fasta scores: E(): 2.1e-15, 39.71% id in 141 aa, and to Bacillus halodurans protein-tyrosine-phosphatase BH3769 TR:Q9K6G0 (EMBL:AP001519) (161 aa) fasta scores: E(): 6.2e-09, 34.5% id in 142 aa; low molecular weight protein-tyrosine-phosphatase 2270724 2861002 SAR2203 Staphylococcus aureus subsp. aureus MRSA252 low molecular weight protein-tyrosine-phosphatase YP_041563.1 2270305 R 282458 CDS YP_041564.1 49484340 2861003 complement(2270721..2271767) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwlC SW:YWLC_BACSU (P39153) (346 aa) fasta scores: E(): 2.5e-44, 40.22% id in 348 aa, and to Bacillus halodurans hypothetical protein BH3771 TR:Q9K6F8 (EMBL:AP001519) (348 aa) fasta scores: E(): 1.2e-43, 43.93% id in 330 aa; hypothetical protein 2271767 2861003 SAR2204 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041564.1 2270721 R 282458 CDS YP_041565.1 49484341 2861004 complement(2271851..2272687) 1 NC_002952.2 Similar to Escherichia coli heme biosynthesis protein HemK SW:HEMK_ECOLI (P37186) (277 aa) fasta scores: E(): 3.5e-19, 32.36% id in 275 aa, and to Bacillus subtilis HemK protein homologue SW:HEMK_BACSU (P45873) (288 aa) fasta scores: E(): 1.7e-34, 40.36% id in 275 aa; hypothetical protein 2272687 2861004 SAR2205 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041565.1 2271851 R 282458 CDS YP_041566.1 49484342 2860148 complement(2272674..2273750) 1 NC_002952.2 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 2273750 prfA 2860148 prfA Staphylococcus aureus subsp. aureus MRSA252 peptide chain release factor 1 YP_041566.1 2272674 R 282458 CDS YP_041567.1 49484343 2861005 complement(2273751..2274350) 1 NC_002952.2 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 2274350 2861005 SAR2207 Staphylococcus aureus subsp. aureus MRSA252 thymidine kinase YP_041567.1 2273751 R 282458 CDS YP_041568.1 49484344 2860925 complement(2274697..2274951) 1 NC_002952.2 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 2274951 rpmE2 2860925 rpmE2 Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L31 YP_041568.1 2274697 R 282458 CDS YP_041569.1 49484345 2859307 complement(2275069..2276385) 1 NC_002952.2 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 2276385 rho 2859307 rho Staphylococcus aureus subsp. aureus MRSA252 transcription termination factor Rho YP_041569.1 2275069 R 282458 CDS YP_041570.1 49484346 2861006 complement(2276632..2278059) 1 NC_002952.2 Similar to Bacillus subtilis betaine aldehyde dehydrogenase GbsA SW:DHAB_BACSU (P71016) (490 aa) fasta scores: E(): 1.2e-59, 40.33% id in 476 aa, and to Caulobacter crescentus aldehyde dehydrogenase CC0419 TR:Q9AB15 (EMBL:AE005714) (479 aa) fasta scores: E(): 2.4e-87, 50.94% id in 475 aa; aldehyde dehydrogenase 2278059 2861006 SAR2210 Staphylococcus aureus subsp. aureus MRSA252 aldehyde dehydrogenase YP_041570.1 2276632 R 282458 CDS YP_041571.1 49484347 2860014 complement(2278297..2278635) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YodB SW:YODB_BACSU (O34844) (112 aa) fasta scores: E(): 1.5e-12, 38.46% id in 104 aa, and to Bacillus halodurans hypothetical protein BH3303 TR:Q9RC48 (EMBL:AB024562) (107 aa) fasta scores: E(): 2.2e-08, 36.53% id in 104 aa; hypothetical protein 2278635 2860014 SAR2211 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041571.1 2278297 R 282458 CDS YP_041572.1 49484348 2861319 complement(2278721..2279980) 1 NC_002952.2 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2279980 murA2 2861319 murA2 Staphylococcus aureus subsp. aureus MRSA252 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_041572.1 2278721 R 282458 CDS YP_041573.1 49484349 2860015 complement(2280446..2281306) 1 NC_002952.2 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; induced by anaerobic conditions in Bacillus subtilis; fructose-bisphosphate aldolase 2281306 2860015 SAR2213 Staphylococcus aureus subsp. aureus MRSA252 fructose-bisphosphate aldolase YP_041573.1 2280446 R 282458 CDS YP_041574.1 49484350 2860016 2281524..2282045 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3788 TR:Q9K6E1 (EMBL:AP001520) (178 aa) fasta scores: E(): 7.4e-06, 25.69% id in 179 aa, and to Bacillus subtilis hypothetical protein YwjG SW:YWJG_BACSU (P06629) (173 aa) fasta scores: E(): 5e-05, 29.54% id in 176 aa; hypothetical protein 2282045 2860016 SAR2214 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041574.1 2281524 D 282458 CDS YP_041575.1 49484351 2859288 complement(2282154..2283764) 1 NC_002952.2 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 2283764 pyrG 2859288 pyrG Staphylococcus aureus subsp. aureus MRSA252 CTP synthetase YP_041575.1 2282154 R 282458 CDS YP_041576.1 49484352 2860172 complement(2284100..2284630) 1 NC_002952.2 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 2284630 rpoE 2860172 rpoE Staphylococcus aureus subsp. aureus MRSA252 DNA-directed RNA polymerase subunit delta YP_041576.1 2284100 R 282458 CDS YP_041577.1 49484353 2860017 complement(2284742..2285602) 1 NC_002952.2 Similar to Bacillus subtilis spermine/spermidine acetyltransferase BltD SW:BLTD_BACSU (P39909) (152 aa) fasta scores: E(): 0.0005, 27.4% id in 135 aa, and to Bacillus halodurans hypothetical protein BH3804 TR:Q9K6C5 (EMBL:AP001520) (167 aa) fasta scores: E(): 1.4e-15, 39.1% id in 156 aa; acetyltransferase 2285602 2860017 SAR2217 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_041577.1 2284742 R 282458 CDS YP_041578.1 49484354 2860018 2286026..2286829 1 NC_002952.2 catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type II pantothenate kinases are not regulated by feedback inhibition by coenzyme A; pantothenate kinase 2286829 2860018 SAR2218 Staphylococcus aureus subsp. aureus MRSA252 pantothenate kinase YP_041578.1 2286026 D 282458 CDS YP_041579.1 49484355 2860127 complement(2286955..2287626) 1 NC_002952.2 No significant database matches to the full length CDS. N-terminus is weakly similar to N-terminal region of Caenorhabditis elegans hypothetical protein Y71F9AL.1 TR:Q9N4H1 (EMBL:AC024200) (323 aa) fasta scores: E(): 9, 24.82% id in 141 aa; hypothetical protein 2287626 2860127 SAR2219 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041579.1 2286955 R 282458 CDS YP_041580.1 49484356 2860050 complement(2288025..2289218) 1 NC_002952.2 No significant database matches to the full length CDS. N-terminus is weakly similar to N-terminal region of Pasteurella haemolytica probable phosphoribosylglycinamide formyltransferase 2 PurT SW:PURT_PASHA (P46927) (392 aa) fasta scores: E(): 4.2, 22.83% id in 289 aa; hypothetical protein 2289218 2860050 SAR2220 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041580.1 2288025 R 282458 CDS YP_041581.1 49484357 2860051 complement(2289218..2290402) 1 NC_002952.2 N-terminus is similar to N-terminal region of Escherichia coli aminobenzoyl-glutamate utilization protein B AbgB SW:ABGB_ECOLI (P76052) (481 aa) fasta scores: E(): 2.9e-14, 32.98% id in 285 aa. Similar to full length Mycobacterium tuberculosis aminohydrolase RV3306c TR:O53358 (EMBL:AL021841) (394 aa) fasta scores: E(): 1.4e-36, 33.59% id in 381 aa; peptidase 2290402 2860051 SAR2221 Staphylococcus aureus subsp. aureus MRSA252 peptidase YP_041581.1 2289218 R 282458 CDS YP_041582.1 49484358 2859811 2290712..2291182 1 NC_002952.2 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2291182 luxS 2859811 luxS Staphylococcus aureus subsp. aureus MRSA252 S-ribosylhomocysteinase YP_041582.1 2290712 D 282458 CDS YP_041583.1 49484359 2860052 complement(2291334..2291684) 1 NC_002952.2 Similar to Deinococcus radiodurans hypothetical protein DR2024 TR:Q9RSU8 (EMBL:AE002039) (120 aa) fasta scores: E(): 2e-10, 41.74% id in 103 aa, and to Pseudomonas aeruginosa hypothetical protein PA0806 TR:Q9I5D2 (EMBL:AE004515) (131 aa) fasta scores: E(): 0.00064, 34.25% id in 108 aa; hypothetical protein 2291684 2860052 SAR2223 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041583.1 2291334 R 282458 CDS YP_041584.1 49484360 2859281 complement(2291698..2292999) 1 NC_002952.2 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 2292999 pyn 2859281 pyn Staphylococcus aureus subsp. aureus MRSA252 pyrimidine-nucleoside phosphorylase YP_041584.1 2291698 R 282458 CDS YP_041585.1 49484361 2859588 complement(2293279..2293941) 1 NC_002952.2 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 2293941 deoC2 2859588 deoC2 Staphylococcus aureus subsp. aureus MRSA252 deoxyribose-phosphate aldolase YP_041585.1 2293279 R 282458 CDS YP_041586.1 49484362 2859590 2294256..2294966 1 NC_002952.2 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 2294966 deoD 2859590 deoD Staphylococcus aureus subsp. aureus MRSA252 purine nucleoside phosphorylase YP_041586.1 2294256 D 282458 CDS YP_041587.1 49484363 2860053 complement(2295087..2295530) 1 NC_002952.2 Similar to Listeria innocua non-heme iron-containing ferritin SW:FRI_LISIN (P80725) (156 aa) fasta scores: E(): 9.5e-21, 43.83% id in 146 aa, and to Bacillus subtilis general stress protein 20U SW:G20U_BACSU (P80879) (144 aa) fasta scores: E(): 1.2e-28, 52.11% id in 142 aa; non-heme iron-containing ferritin 2295530 2860053 SAR2227 Staphylococcus aureus subsp. aureus MRSA252 non-heme iron-containing ferritin YP_041587.1 2295087 R 282458 CDS YP_041588.1 49484364 2860054 complement(2295730..2296143) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0852 TR:Q9KEK0 (EMBL:AP001510) (134 aa) fasta scores: E(): 1.3e-08, 31.57% id in 133 aa, and to Bacillus subtilis hypothetical protein YuxK SW:YUXK_BACSU (P40761) (137 aa) fasta scores: E(): 5.3e-06, 30.23% id in 129 aa; hypothetical protein 2296143 2860054 SAR2228 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041588.1 2295730 R 282458 CDS YP_041589.1 49484365 2860055 complement(2296592..2297965) 1 NC_002952.2 hypothetical protein 2297965 2860055 SAR2229 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041589.1 2296592 R 282458 CDS YP_041590.1 49484366 2860056 complement(2298638..2298868) 1 NC_002952.2 Doubtful CDS. No significant database matches; hypothetical protein 2298868 2860056 SAR2230 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041590.1 2298638 R 282458 CDS YP_041591.1 49484367 2860057 complement(2298899..2299837) 1 NC_002952.2 Similar to Streptococcus mutans mannose-6-phosphate isomerase Pmi SW:MANA_STRMU (Q59935) (316 aa) fasta scores: E(): 3e-56, 46.62% id in 311 aa, and to Bacillus halodurans mannnose-6 phosphate isomerase BH3916 TR:Q9Z9T1 (EMBL:AB011838) (315 aa) fasta scores: E(): 3.7e-57, 43.59% id in 312 aa; mannose-6-phosphate isomerase 2299837 2860057 SAR2231 Staphylococcus aureus subsp. aureus MRSA252 mannose-6-phosphate isomerase YP_041591.1 2298899 R 282458 CDS YP_041592.1 49484368 2860058 complement(2300273..2300938) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhfK TR:O07609 (EMBL:Y14083) (214 aa) fasta scores: E(): 2.6e-23, 41.81% id in 220 aa, and to Bacillus halodurans hypothetical protein BH1520 TR:Q9KCP9 (EMBL:AP001512) (213 aa) fasta scores: E(): 3.9e-21, 36.81% id in 220 aa; hypothetical protein 2300938 2860058 SAR2232 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041592.1 2300273 R 282458 CDS YP_041593.1 49484369 2859259 2301090..2301410 1 NC_002952.2 Previously sequenced as Staphylococcus aureus zinc and cobalt transport repressor protein CzrA TR:O85142 (EMBL:AF044951) (106 aa) fasta scores: E(): 4e-38, 100% id in 106 aa. Similar to Bacillus subtilis hypothetical protein YozA TR:O31844 (EMBL:Z99114) (107 aa) fasta scores: E(): 2e-13, 49% id in 100 aa; zinc and cobalt transport repressor protein 2301410 czrA 2859259 czrA Staphylococcus aureus subsp. aureus MRSA252 zinc and cobalt transport repressor protein YP_041593.1 2301090 D 282458 CDS YP_041594.1 49484370 2859260 2301412..2302392 1 NC_002952.2 Previously sequenced as Staphylococcus aureus zinc resistance protein CzrB TR:Q9ZNF5 (EMBL:AB016431) (325 aa) fasta scores: E(): 3.2e-116, 98.46% id in 326 aa. Similar to Bacillus subtilis cation transport protein YrdO TR:O07084 (EMBL:U93876) (311 aa) fasta scores: E(): 4.1e-62, 56.95% id in 309 aa; zinc resistance protein 2302392 czrB 2859260 czrB Staphylococcus aureus subsp. aureus MRSA252 zinc resistance protein YP_041594.1 2301412 D 282458 CDS YP_041595.1 49484371 2860059 2302658..2303749 1 NC_002952.2 No significant database matches. Previously sequenced as Staphylococcus aureus lytic regulatory protein TR:Q9ZB00 (EMBL:U67965) (370 aa) fasta scores: E(): 4.1e-113, 97.5% id in 360 aa; hypothetical protein 2303749 2860059 SAR2235 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041595.1 2302658 D 282458 CDS YP_041597.1 49484373 2860063 2307489..2307581 1 NC_002952.2 Doubtful CDS. No database matches; hypothetical protein 2307581 2860063 SAR2239 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041597.1 2307489 D 282458 CDS YP_041598.1 49484374 2860064 complement(2307711..2308568) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1746 TR:Q9KC28 (EMBL:AP001513) (282 aa) fasta scores: E(): 8.6e-14, 28.47% id in 288 aa, and to Bacillus subtilis hypothetical protein YwpJ TR:P94592 (EMBL:Z83337) (285 aa) fasta scores: E(): 6.1e-13, 24.74% id in 291 aa; haloacid dehalogenase-like hydrolase 2308568 2860064 SAR2240 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_041598.1 2307711 R 282458 CDS YP_041599.1 49484375 2860065 complement(2308636..2309418) 1 NC_002952.2 Similar to Thermoactinomyces vulgaris ATP-binding protein-homologue Orf-4 TR:Q9AJF6 (EMBL:AB047926) (266 aa) fasta scores: E(): 5.8e-34, 47.12% id in 261 aa, and to the C-terminal region Escherichia coli molybdenum transport ATP-binding protein ModF SW:MODF_ECOLI (P31060) (490 aa) fasta scores: E(): 1.3e-17, 35.71% id in 224 aa; ABC transporter ATP-binding protein 2309418 2860065 SAR2241 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041599.1 2308636 R 282458 CDS YP_041600.1 49484376 2859920 complement(2309650..2311455) 1 NC_002952.2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 2311455 glmS 2859920 glmS Staphylococcus aureus subsp. aureus MRSA252 glucosamine--fructose-6-phosphate aminotransferase YP_041600.1 2309650 R 282458 CDS YP_041601.1 49484377 2860066 2311923..2312120 1 NC_002952.2 Poor database matches. Doubtful CDS; hypothetical protein 2312120 2860066 SAR2243 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041601.1 2311923 D 282458 CDS YP_041602.1 49484378 2861315 2312136..2313674 1 NC_002952.2 Similar to Staphylococcus carnosus PTS system, mannitol-specific IIBC component MtlA SW:PTMB_STACA (P28008) (518 aa) fasta scores: E(): 2.5e-163, 84.01% id in 513 aa, and to Bacillus halodurans PTS system, mannitol-specific IIBC component BH3854 SW:PTMB_BACHD (Q9K678) (468 aa) fasta scores: E(): 1.1e-80, 55.35% id in 495 aa; PTS system mannitol-specific transporter subunit IIBC 2313674 mtlA 2861315 mtlA Staphylococcus aureus subsp. aureus MRSA252 PTS system mannitol-specific transporter subunit IIBC YP_041602.1 2312136 D 282458 CDS YP_041603.1 49484379 2860067 2313709..2315841 1 NC_002952.2 Similar to Bacillus subtilis cel operon transcriptional regulator (antiterminator) CelR SW:CELR_BACSU (P46321) (641 aa) fasta scores: E(): 4.9e-13, 24.24% id in 532 aa, and to Bacillus subtilis probable LysR family transcriptional regulator YdaA TR:P96574 (EMBL:AB001488) (694 aa) fasta scores: E(): 7e-50, 29.89% id in 726 aa; transcriptional antiterminator 2315841 2860067 SAR2245 Staphylococcus aureus subsp. aureus MRSA252 transcriptional antiterminator YP_041603.1 2313709 D 282458 CDS YP_041604.1 49484380 2861317 2315853..2316287 1 NC_002952.2 Previously sequenced as Staphylococcus aureus PTS system, mannitol-specific IIA component MtlF SW:PTMA_STAAU (P17875) (143 aa) fasta scores: E(): 5.1e-49, 99.3% id in 143 aa. Similar to Staphylococcus carnosus PTS system, mannitol-specific IIA component MtlF SW:PTMA_STACA (P17876) (143 aa) fasta scores: E(): 4.7e-39, 81.69% id in 142 aa; PTS system mannitol-specific transporter subunit IIA 2316287 mtlF 2861317 mtlF Staphylococcus aureus subsp. aureus MRSA252 PTS system mannitol-specific transporter subunit IIA YP_041604.1 2315853 D 282458 CDS YP_041605.1 49484381 2861316 2316287..2317393 1 NC_002952.2 Similar to Streptococcus mutans mannitol-1-phosphate 5-dehydrogenase MtlD SW:MTLD_STRMU (Q02418) (382 aa) fasta scores: E(): 8.5e-30, 41.68% id in 379 aa. Previously sequenced as Staphylococcus aureus mannitol-1-phosphate 5-dehydrogenase TR:Q9RL68 (EMBL:Y09927) (368 aa) fasta scores: E(): 2.6e-131, 98.09% id in 368 aa; mannitol-1-phosphate 5-dehydrogenase 2317393 mtlD 2861316 mtlD Staphylococcus aureus subsp. aureus MRSA252 mannitol-1-phosphate 5-dehydrogenase YP_041605.1 2316287 D 282458 CDS YP_041606.1 49484382 2860068 complement(2325364..2327010) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 7e-199, 99.453% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 3e-99, 52.115% id in 520 aa; transposase 2327010 2860068 SAR2251 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_041606.1 2325364 R 282458 CDS YP_041607.1 49484383 2860069 complement(2327307..2328662) 1 NC_002952.2 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 2328662 glmM 2860069 glmM Staphylococcus aureus subsp. aureus MRSA252 phosphoglucosamine mutase YP_041607.1 2327307 R 282458 CDS YP_041608.1 49484384 2860070 complement(2328689..2329621) 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY1037 TR:Q99ZW9 (EMBL:AE006548) (318 aa) fasta scores: E(): 6.5e-10, 24.83% id in 310 aa, and to the N-terminal region of Bacillus subtilis hypothetical protein YbbR TR:O34659 (EMBL:Z99104) (483 aa) fasta scores: E(): 2.2e-20, 28.25% id in 315 aa; hypothetical protein 2329621 2860070 SAR2253 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041608.1 2328689 R 282458 CDS YP_041609.1 49484385 2860071 complement(2329623..2330432) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YbbQ TR:Q45589 (EMBL:Z99104) (273 aa) fasta scores: E(): 2.5e-52, 56.42% id in 257 aa, and to Bacillus halodurans hypothetical protein BH0265 TR:Q9KG48 (EMBL:AP001507) (274 aa) fasta scores: E(): 3.6e-48, 56.22% id in 249 aa; hypothetical protein 2330432 2860071 SAR2254 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041609.1 2329623 R 282458 CDS YP_041610.1 49484386 2860896 complement(2330622..2331530) 1 NC_002952.2 Similar to Bacillus caldovelox arginase RocF SW:ARGI_BACCD (P53608) (299 aa) fasta scores: E(): 3.1e-57, 53% id in 300 aa, and to Bacillus subtilis arginase RocF SW:ARGI_BACSU (P39138) (296 aa) fasta scores: E(): 4e-55, 51.66% id in 300 aa; arginase 2331530 rocF 2860896 rocF Staphylococcus aureus subsp. aureus MRSA252 arginase YP_041610.1 2330622 R 282458 CDS YP_041611.1 49484387 2860072 complement(2337747..2338811) 1 NC_002952.2 Similar to Bacillus subtilis Mrp protein homologue YbaL SW:MRP_BACSU (P50863) (352 aa) fasta scores: E(): 1.9e-84, 63.53% id in 351 aa, and to Bacillus halodurans ATP-binding Mrp protein BH0240 TR:Q9KG72 (EMBL:AP001507) (350 aa) fasta scores: E(): 7.9e-76, 60.84% id in 355 aa; hypothetical protein 2338811 2860072 SAR2256 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041611.1 2337747 R 282458 CDS YP_041612.1 49484388 2860074 complement(2340591..2341058) 1 NC_002952.2 Poor database matches. Similar to Borrelia burgdorferi conserved hypothetical integral membrane protein BB0717 TR:O51659 (EMBL:AE001171) (160 aa) fasta scores: E(): 0.24, 30.08% id in 123 aa; hypothetical protein 2341058 2860074 SAR2259 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041612.1 2340591 R 282458 CDS YP_041613.1 49484389 2860075 complement(2341186..2342529) 1 NC_002952.2 Similar to Vibrio cholerae multidrug transporter VC1597 TR:Q9KRN9 (EMBL:AE004237) (477 aa) fasta scores: E(): 2.2e-29, 28.81% id in 413 aa, and to Deinococcus radiodurans multidrug-efflux transporter DR1327 TR:Q9RUQ5 (EMBL:AE001979) (477 aa) fasta scores: E(): 1.4e-27, 26.83% id in 436 aa; transport protein 2342529 2860075 SAR2260 Staphylococcus aureus subsp. aureus MRSA252 transport protein YP_041613.1 2341186 R 282458 CDS YP_041614.1 49484390 2860076 complement(2342707..2343390) 1 NC_002952.2 Similar to Bacillus cereus hemolysin III SW:HLY3_BACCE (P54176) (219 aa) fasta scores: E(): 2.5e-20, 34.8% id in 204 aa, and to Streptococcus pyogenes hemolysin III SPY1159 TR:Q99ZM9 (EMBL:AE006557) (216 aa) fasta scores: E(): 1e-42, 55.14% id in 214 aa; hypothetical protein 2343390 2860076 SAR2261 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041614.1 2342707 R 282458 CDS YP_041615.1 49484391 2860077 complement(2343409..2344596) 1 NC_002952.2 Similar to Saccharomyces cerevisiae UDP-N-acetylglucosamine pyrophosphorylase UAP1 SW:UAP1_YEAST (P43123) (477 aa) fasta scores: E(): 3.5e-28, 33.41% id in 407 aa, and to Chlamydia trachomatis AgX-1 homolog-UDP-glucose pyrophosphorylase CT715 TR:O84720 (EMBL:AE001342) (455 aa) fasta scores: E(): 2.6e-26, 30.92% id in 401 aa; UTP--glucose-1-phosphate uridylyltransferase 2344596 2860077 SAR2262 Staphylococcus aureus subsp. aureus MRSA252 UTP--glucose-1-phosphate uridylyltransferase YP_041615.1 2343409 R 282458 CDS YP_041616.1 49484392 2860078 complement(2344640..2345155) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YvsG SW:YVSG_BACSU (O32205) (160 aa) fasta scores: E(): 7.1e-18, 37.97% id in 158 aa, and to Bacillus halodurans hypothetical protein BH2138 TR:Q9KAZ8 (EMBL:AP001514) (159 aa) fasta scores: E(): 1e-14, 34.61% id in 156 aa; hypothetical protein 2345155 2860078 SAR2263 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041616.1 2344640 R 282458 CDS YP_041617.1 49484393 2860079 2345332..2345592 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YnzG TR:O31800 (EMBL:Z99113) (83 aa) fasta scores: E(): 7.9e-05, 29.76% id in 84 aa, and to Bacillus halodurans hypothetical protein BH3607 TR:Q9K6W7 (EMBL:AP001519) (83 aa) fasta scores: E(): 0.049, 34.21% id in 76 aa; hypothetical protein 2345592 2860079 SAR2264 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041617.1 2345332 D 282458 CDS YP_041618.1 49484394 2860080 complement(2345724..2347094) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3947 TR:Q9K5Y8 (EMBL:AP001520) (460 aa) fasta scores: E(): 3.2e-76, 47.31% id in 465 aa, and to Vibrio cholerae hypothetical protein VCA0076 TR:Q9KN89 (EMBL:AE004350) (458 aa) fasta scores: E(): 1.3e-73, 46.48% id in 441 aa; hypothetical protein 2347094 2860080 SAR2265 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041618.1 2345724 R 282458 CDS YP_041619.1 49484395 2860081 complement(2347330..2348298) 1 NC_002952.2 Similar to Escherichia coli citrate-dependent iron transport protein FecD SW:FECD_ECOLI (P15029) (318 aa) fasta scores: E(): 1.1e-38, 39.8% id in 314 aa, and to Bacillus subtilis hypothetical protein YfmE TR:O34832 (EMBL:Z99108) (333 aa) fasta scores: E(): 8.6e-50, 46.3% id in 311 aa; FecCD transport family protein 2348298 2860081 SAR2266 Staphylococcus aureus subsp. aureus MRSA252 FecCD transport family protein YP_041619.1 2347330 R 282458 CDS YP_041620.1 49484396 2860082 complement(2348295..2349326) 1 NC_002952.2 Similar to Bacillus subtilis ferrichrome ABC transporter permease FhuB SW:FHUB_BACSU (P49936) (384 aa) fasta scores: E(): 2.7e-39, 37.03% id in 324 aa, and to Bacillus subtilis hypothetical protein YfmD TR:O34933 (EMBL:Z99108) (333 aa) fasta scores: E(): 3.2e-54, 46.97% id in 330 aa; FecCD transport family protein 2349326 2860082 SAR2267 Staphylococcus aureus subsp. aureus MRSA252 FecCD transport family protein YP_041620.1 2348295 R 282458 CDS YP_041621.1 49484397 2860083 complement(2349338..2350321) 1 NC_002952.2 Similar to Escherichia coli iron citrate-dependent iron transport, periplasmic protein FecB SW:FECB_ECOLI (P15028) (300 aa) fasta scores: E(): 2.9e-20, 37.23% id in 282 aa, and to Bacillus subtilis hypothetical protein YhfQ TR:O07616 (EMBL:Y14084) (348 aa) fasta scores: E(): 2e-32, 38.6% id in 316 aa; transport system binding lipoprotein 2350321 2860083 SAR2268 Staphylococcus aureus subsp. aureus MRSA252 transport system binding lipoprotein YP_041621.1 2349338 R 282458 CDS YP_041622.1 49484398 2860084 complement(2350714..2351784) 1 NC_002952.2 Similar to Thermotoga maritima hypothetical protein TM1597 TR:Q9X1T3 (EMBL:AE001804) (354 aa) fasta scores: E(): 2.3e-17, 28.32% id in 346 aa. N-terminus is weakly similar to the N-terminal region of Staphylococcus aureus alanine racemase Alr SW:ALR_STAAU (Q9ZAH5) (382 aa) fasta scores: E(): 0.018, 22.65% id in 256 aa; hypothetical protein 2351784 2860084 SAR2269 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041622.1 2350714 R 282458 CDS YP_041623.1 49484399 2860085 complement(2351791..2353548) 1 NC_002952.2 Similar to Rhizobium sp hypothetical protein Y4xN SW:Y4XN_RHISN (P55706) (628 aa) fasta scores: E(): 4.9e-10, 22.36% id in 617 aa, and to Escherichia coli aerobactin siderophore biosynthesis protein IucA SW:IUCA_ECOLI (Q47316) (575 aa) fasta scores: E(): 2.1e-05, 21.64% id in 596 aa; hypothetical protein 2353548 2860085 SAR2270 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041623.1 2351791 R 282458 CDS YP_041624.1 49484400 2860086 complement(2353535..2354728) 1 NC_002952.2 Similar to Zymomonas mobilis transporter DitE TR:Q9XBR9 (EMBL:AF157493) (431 aa) fasta scores: E(): 5.6e-22, 26.3% id in 403 aa, and to Mycobacterium smegmatis hypothetical membrane protein TR:Q50396 (EMBL:U46844) (412 aa) fasta scores: E(): 1.2e-17, 24.73% id in 376 aa; hypothetical protein 2354728 2860086 SAR2271 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041624.1 2353535 R 282458 CDS YP_041625.1 49484401 2860087 2354830..2356806 1 NC_002952.2 Internal region of the CDS is similar to the internal regions of Escherichia coli aerobactin siderophore biosynthesis protein IucC SW:IUCC_ECOLI (Q47318) (580 aa) fasta scores: E(): 2e-07, 22.91% id in 384 aa, and Rhizobium sp hypothetical protein Y4xN SW:Y4XN_RHISN (P55706) (628 aa) fasta scores: E(): 3.2e-10, 24.02% id in 412 aa; hypothetical protein 2356806 2860087 SAR2272 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041625.1 2354830 D 282458 CDS YP_041626.1 49484402 2859871 complement(2356967..2357476) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus alkaline shock protein 23 Asp23 TR:Q53485 (EMBL:S76213) (169 aa) fasta scores: E(): 6.8e-55, 100% id in 169 aa. Similar to Lactococcus lactis hypothetical protein YmgG TR:Q9CG71 (EMBL:AE006356) (183 aa) fasta scores: E(): 1.3e-13, 40.94% id in 127 aa; alkaline shock protein 23 2357476 asp23 2859871 asp23 Staphylococcus aureus subsp. aureus MRSA252 alkaline shock protein 23 YP_041626.1 2356967 R 282458 CDS YP_041627.1 49484403 2860088 complement(2357539..2357778) 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY1263 TR:Q99ZE4 (EMBL:AE006565) (62 aa) fasta scores: E(): 0.012, 36.06% id in 61 aa, and to Lactococcus lactis hypothetical protein YmgH TR:Q9CG70 (EMBL:AE006356) (62 aa) fasta scores: E(): 0.041, 34.42% id in 61 aa; hypothetical protein 2357778 2860088 SAR2274 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041627.1 2357539 R 282458 CDS YP_041628.1 49484404 2860089 complement(2357791..2358327) 1 NC_002952.2 Poor database matches. Similar to Lactococcus lactis unknown protein YtgA TR:Q9CEF1 (EMBL:AE006418) (186 aa) fasta scores: E(): 0.053, 24.13% id in 174 aa; hypothetical protein 2358327 2860089 SAR2275 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041628.1 2357791 R 282458 CDS YP_041629.1 49484405 2861470 complement(2358502..2360064) 1 NC_002952.2 Similar to Bacillus subtilis glycine betaine transporter OpuD SW:OPUD_BACSU (P54417) (512 aa) fasta scores: E(): 5.6e-102, 53.15% id in 508 aa, and to Listeria monocytogenes glycine betaine transporter BetL TR:Q9X4A5 (EMBL:AF102174) (507 aa) fasta scores: E(): 3.7e-99, 52.43% id in 492 aa; glycine betaine transporter 2 2360064 opuD2 2861470 opuD2 Staphylococcus aureus subsp. aureus MRSA252 glycine betaine transporter 2 YP_041629.1 2358502 R 282458 CDS YP_041630.1 49484406 2860090 complement(2360372..2361379) 1 NC_002952.2 Similar to Bacillus halodurans alginate lyase BH0738 TR:Q9KEW1 (EMBL:AP001509) (339 aa) fasta scores: E(): 5.7e-47, 43.75% id in 336 aa, and to Lactococcus lactis quinone oxidoreductase Qor TR:Q9CHL2 (EMBL:AE006305) (328 aa) fasta scores: E(): 3e-40, 40.47% id in 336 aa; zinc-binding dehydrogenase 2361379 2860090 SAR2277 Staphylococcus aureus subsp. aureus MRSA252 zinc-binding dehydrogenase YP_041630.1 2360372 R 282458 CDS YP_041631.1 49484407 2860091 complement(2361614..2362618) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfmJ TR:O34812 (EMBL:Z99108) (339 aa) fasta scores: E(): 5.4e-62, 52.55% id in 333 aa, and to Escherichia coli NADP-dependent oxidoreductase YncB SW:YNCB_ECOLI (P76113) (353 aa) fasta scores: E(): 2.6e-52, 45.85% id in 338 aa; zinc-binding dehydrogenase 2362618 2860091 SAR2278 Staphylococcus aureus subsp. aureus MRSA252 zinc-binding dehydrogenase YP_041631.1 2361614 R 282458 CDS YP_041632.1 49484408 2861024 complement(2362898..2363767) 1 NC_002952.2 C-terminus region is similar to the C-terminal regions of Lactococcus lactis hypothetical protein YriC TR:Q9CEV4 (EMBL:AE006403) (282 aa) fasta scores: E(): 4.4e-09, 24% id in 250 aa, and Lactococcus lactis hypothetical protein TR:Q9ZB16 (EMBL:U60828) (307 aa) fasta scores: E(): 7.2e-08, 22.98% id in 248 aa; hypothetical protein 2363767 2861024 SAR2279 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041632.1 2362898 R 282458 CDS YP_041633.1 49484409 2859693 complement(2364033..2365445) 1 NC_002952.2 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 2365445 lacG 2859693 lacG Staphylococcus aureus subsp. aureus MRSA252 6-phospho-beta-galactosidase YP_041633.1 2364033 R 282458 CDS YP_041634.1 49484410 2859691 complement(2365463..2367175) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus PTS system, lactose-specific IIBC component LacE SW:PTLB_STAAU (P11162) (572 aa) fasta scores: E(): 1.3e-216, 99.82% id in 570 aa. Similar to Streptococcus mutans PTS system, lactose-specific IIBC component LacE SW:PTLB_STRMU (P50976) (568 aa) fasta scores: E(): 1.1e-168, 76.27% id in 569 aa; PTS system lactose-specific transporter subunit IIBC 2367175 lacE 2859691 lacE Staphylococcus aureus subsp. aureus MRSA252 PTS system lactose-specific transporter subunit IIBC YP_041634.1 2365463 R 282458 CDS YP_041635.1 49484411 2859692 complement(2367181..2367492) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus PTS system, lactose-specific IIA component LacF SW:PTLA_STAAU (P02909) (103 aa) fasta scores: E(): 8.2e-39, 100% id in 103 aa. Similar to Streptococcus pyogenes pts system, lactose-specific component iia lacf or spy1918 TR:Q99Y16 (EMBL:AE006616) (105 aa) fasta scores: E(): 6e-30, 76.69% id in 103 aa; PTS system lactose-specific transporter subunit IIA 2367492 lacF 2859692 lacF Staphylococcus aureus subsp. aureus MRSA252 PTS system lactose-specific transporter subunit IIA YP_041635.1 2367181 R 282458 CDS YP_041636.1 49484412 2859690 complement(2367514..2368494) 1 NC_002952.2 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase 2368494 lacD 2859690 lacD Staphylococcus aureus subsp. aureus MRSA252 tagatose 1,6-diphosphate aldolase YP_041636.1 2367514 R 282458 CDS YP_041637.1 49484413 2859689 complement(2368498..2369430) 1 NC_002952.2 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase 2369430 lacC 2859689 lacC Staphylococcus aureus subsp. aureus MRSA252 tagatose-6-phosphate kinase YP_041637.1 2368498 R 282458 CDS YP_041638.1 49484414 2859688 complement(2369443..2369958) 1 NC_002952.2 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB 2369958 lacB 2859688 lacB Staphylococcus aureus subsp. aureus MRSA252 galactose-6-phosphate isomerase subunit LacB YP_041638.1 2369443 R 282458 CDS YP_041639.1 49484415 2859687 complement(2369974..2370402) 1 NC_002952.2 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA 2370402 lacA 2859687 lacA Staphylococcus aureus subsp. aureus MRSA252 galactose-6-phosphate isomerase subunit LacA YP_041639.1 2369974 R 282458 CDS YP_041640.1 49484416 2859694 complement(2370769..2371524) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus lactose phosphotransferase system repressor LacR SW:LACR_STAAU (P16644) (251 aa) fasta scores: E(): 4.7e-93, 99.2% id in 251 aa. Similar to Streptococcus mutans lactose phosphotransferase system repressor LacR SW:LACR_STRMU (P26422) (251 aa) fasta scores: E(): 4.2e-62, 62.94% id in 251 aa; lactose phosphotransferase system repressor 2371524 lacR 2859694 lacR Staphylococcus aureus subsp. aureus MRSA252 lactose phosphotransferase system repressor YP_041640.1 2370769 R 282458 CDS YP_041641.1 49484417 2861025 2371775..2372506 1 NC_002952.2 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 2372506 2861025 SAR2288 Staphylococcus aureus subsp. aureus MRSA252 NAD-dependent deacetylase YP_041641.1 2371775 D 282458 CDS YP_041642.1 49484418 2861026 complement(2372764..2373372) 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YnaE TR:P94483 (EMBL:U66480) (213 aa) fasta scores: E(): 3.2e-08, 26.13% id in 199 aa; hypothetical protein 2373372 2861026 SAR2289 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041642.1 2372764 R 282458 CDS YP_041643.1 49484419 2861027 complement(2373634..2373759) 1 NC_002952.2 Doubtful CDS. No database matches; hypothetical protein 2373759 2861027 SAR2289a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041643.1 2373634 R 282458 CDS YP_041644.1 49484420 2861028 complement(2373980..2374828) 1 NC_002952.2 Similar to Thermotoga maritima aldo/keto reductase oxidoreductase TM1009 TR:Q9X0A2 (EMBL:AE001762) (286 aa) fasta scores: E(): 3.6e-55, 53.95% id in 278 aa, and to Lactococcus lactis oxidoreductase YddB TR:Q9CIM3 (EMBL:AE006270) (272 aa) fasta scores: E(): 6.2e-40, 46.15% id in 273 aa; aldo/keto reductase 2374828 2861028 SAR2290 Staphylococcus aureus subsp. aureus MRSA252 aldo/keto reductase YP_041644.1 2373980 R 282458 CDS YP_041645.1 49484421 2861029 complement(2374898..2375314) 1 NC_002952.2 Similar to Escherichia coli zinc (II) responsive transcriptional activator ZntR SW:ZNTR_ECOLI (P36676) (141 aa) fasta scores: E(): 0.00023, 27.77% id in 108 aa, and to Bacillus subtilis mercuric resistance operon regulatory protein YraB TR:O06008 (EMBL:X92868) (140 aa) fasta scores: E(): 3.7e-10, 36.56% id in 134 aa. Contains coiled-coiled domain, residues 88 to 105; MerR family transcriptional regulator 2375314 2861029 SAR2291 Staphylococcus aureus subsp. aureus MRSA252 MerR family transcriptional regulator YP_041645.1 2374898 R 282458 CDS YP_041646.1 49484422 2859654 2375721..2378147 1 NC_002952.2 Similar to Staphylococcus aureus hyaluronate lyase precursor HysA SW:HYSA_STAAU (Q59801) (807 aa) fasta scores: E(): 0, 87.5% id in 808 aa, and to Streptococcus pneumoniae hyaluronate lyase precursor SP0314 SW:HYSA_STRPN (Q54873) (949 aa) fasta scores: E(): 5.3e-78, 36.75% id in 770 aa. Similar to SAR1892, 74.969% identity (75.716% ungapped) in 811 aa overlap; hyaluronate lyase precursor 2 2378147 hysA2 2859654 hysA2 Staphylococcus aureus subsp. aureus MRSA252 hyaluronate lyase precursor 2 YP_041646.1 2375721 D 282458 CDS YP_041647.1 49484423 2861030 complement(2378207..2379061) 1 NC_002952.2 Poor database matches. C-terminus is similar to the C-terminal region of Borrelia burgdorferi conserved hypothetical protein BB0761 TR:O51702 (EMBL:AE001176) (295 aa) fasta scores: E(): 4.6e-06, 24.46% id in 233 aa; M23/M37 familypeptidase 2379061 2861030 SAR2293 Staphylococcus aureus subsp. aureus MRSA252 M23/M37 familypeptidase YP_041647.1 2378207 R 282458 CDS YP_041648.1 49484424 2861031 complement(2379272..2380087) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhjK TR:O07565 (EMBL:Y14081) (286 aa) fasta scores: E(): 3.7e-25, 30.03% id in 263 aa, and to Pasteurella multocida hypothetical protein PM1047 pm1047 TR:Q9CM01 (EMBL:AE006146) (276 aa) fasta scores: E(): 1.3e-15, 26.56% id in 256 aa; hypothetical protein 2380087 2861031 SAR2294 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041648.1 2379272 R 282458 CDS YP_041649.1 49484425 2861032 2380382..2380807 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Staphylococcus aureus cell surface protein Map-W precursor protein TR:Q9S2Z4 (EMBL:AJ245439) (687 aa) fasta scores: E(): 9.1e-06, 34.02% id in 144 aa. Possible gene remnant; hypothetical protein 2380807 2861032 SAR2295 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041649.1 2380382 D 282458 CDS YP_041650.1 49484426 2861033 complement(2381198..2381902) 1 NC_002952.2 Similar to Bacillus subtilis alpha-acetolactate decarboxylase AlsD SW:ALDC_BACSU (Q04777) (255 aa) fasta scores: E(): 4.1e-25, 34.33% id in 233 aa, and to Enterobacter aerogenes alpha-acetolactate decarboxylase BudA SW:ALDC_ENTAE (P05361) (260 aa) fasta scores: E(): 5.5e-22, 33.33% id in 234 aa. Similar to SAR2679, 74.359% identity (74.359% ungapped) in 234 aa overlap; hypothetical protein 2381902 2861033 SAR2296 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041650.1 2381198 R 282458 CDS YP_041651.1 49484427 2861034 complement(2381939..2383603) 1 NC_002952.2 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; acetolactate synthase 2383603 2861034 SAR2297 Staphylococcus aureus subsp. aureus MRSA252 acetolactate synthase YP_041651.1 2381939 R 282458 CDS YP_041652.1 49484428 2861035 2383883..2383999 1 NC_002952.2 Doubtful CDS; hypothetical protein 2383999 2861035 SAR2297a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041652.1 2383883 D 282458 CDS YP_041653.1 49484429 2861036 complement(2384073..2384255) 1 NC_002952.2 Doubtful CDS; hypothetical protein 2384255 2861036 SAR2297b Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041653.1 2384073 R 282458 CDS YP_041654.1 49484430 2861038 complement(2385333..2386784) 1 NC_002952.2 Similar to Campylobacter jejuni hypothetical protein CJ1552c TR:Q9PMB7 (EMBL:AL139079) (488 aa) fasta scores: E(): 0.00033, 21.5% id in 479 aa, and to Pyrococcus abyssi hypothetical protein PAB1002 TR:Q9UYK0 (EMBL:AJ248287) (428 aa) fasta scores: E(): 0.015, 25.05% id in 467 aa; hypothetical protein 2386784 2861038 SAR2299 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041654.1 2385333 R 282458 CDS YP_041655.1 49484431 2860180 complement(2387118..2387510) 1 NC_002952.2 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 2387510 rpsI 2860180 rpsI Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S9 YP_041655.1 2387118 R 282458 CDS YP_041656.1 49484432 2860908 complement(2387530..2387967) 1 NC_002952.2 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 2387967 rplM 2860908 rplM Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L13 YP_041656.1 2387530 R 282458 CDS YP_041657.1 49484433 2861039 complement(2388216..2389010) 1 NC_002952.2 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2389010 truA 2861039 truA Staphylococcus aureus subsp. aureus MRSA252 tRNA pseudouridine synthase A YP_041657.1 2388216 R 282458 CDS YP_041658.1 49484434 2861040 complement(2389015..2389821) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YbaF TR:P70972 (EMBL:Z99104) (265 aa) fasta scores: E(): 8.6e-45, 45.83% id in 264 aa, and to Streptococcus pyogenes hypothetical protein SPY2193 TR:Q99XI3 (EMBL:AE006636) (266 aa) fasta scores: E(): 1.5e-42, 42.04% id in 264 aa; cobalt transport protein 2389821 2861040 SAR2303 Staphylococcus aureus subsp. aureus MRSA252 cobalt transport protein YP_041658.1 2389015 R 282458 CDS YP_041659.1 49484435 2861041 complement(2389811..2390671) 1 NC_002952.2 with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2390671 cbiO 2861041 cbiO Staphylococcus aureus subsp. aureus MRSA252 cobalt transporter ATP-binding subunit YP_041659.1 2389811 R 282458 CDS YP_041660.1 49484436 2861042 complement(2390668..2391477) 1 NC_002952.2 with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2391477 cbiO 2861042 cbiO Staphylococcus aureus subsp. aureus MRSA252 cobalt transporter ATP-binding subunit YP_041660.1 2390668 R 282458 CDS YP_041661.1 49484437 2861043 2391853..2392608 1 NC_002952.2 C-terminal region is similar to Lactobacillus johnsonii insertion element IS1223 hypothetical protein SW:YI3A_LACJO (Q48585) (177 aa) fasta scores: E(): 2.7e-08, 33.140% id in 172 aa, and Mycoplasma mycoides insertion element IS1296 hypothetical protein SW:YI6A_MYCMY (Q50239) (180 aa) fasta scores: E(): 0.0092, 30.526% id in 190 aa; insertion element protein 2392608 2861043 SAR2306 Staphylococcus aureus subsp. aureus MRSA252 insertion element protein YP_041661.1 2391853 D 282458 CDS YP_041662.1 49484438 2861044 2392632..2393420 1 NC_002952.2 Similar to the C-terminal region of Enterococcus faecium transposase TR:Q47815 (EMBL:L40841) (310 aa) fasta scores: E(): 1.9e-39, 46.183% id in 262 aa, and to the full length Neisseria gonorrhoeae hypothetical protein TR:Q50996 (EMBL:L36381) (267 aa) fasta scores: E(): 1.1e-27, 39.689% id in 257 aa; transposase 2393420 2861044 SAR2307 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_041662.1 2392632 D 282458 CDS YP_041663.1 49484439 2860912 complement(2393673..2394041) 1 NC_002952.2 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 2394041 rplQ 2860912 rplQ Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L17 YP_041663.1 2393673 R 282458 CDS YP_041664.1 49484440 2860168 complement(2394058..2395002) 1 NC_002952.2 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 2395002 rpoA 2860168 rpoA Staphylococcus aureus subsp. aureus MRSA252 DNA-directed RNA polymerase subunit alpha YP_041664.1 2394058 R 282458 CDS YP_041665.1 49484441 2861447 complement(2395077..2395466) 1 NC_002952.2 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 2395466 rpsK 2861447 rpsK Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S11 YP_041665.1 2395077 R 282458 CDS YP_041666.1 49484442 2861449 complement(2395490..2395855) 1 NC_002952.2 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 2395855 rpsM 2861449 rpsM Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S13 YP_041666.1 2395490 R 282458 CDS YP_041667.1 49484443 2860167 complement(2395878..2395991) 1 NC_002952.2 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 2395991 rpmJ 2860167 rpmJ Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L36 YP_041667.1 2395878 R 282458 CDS YP_041668.1 49484444 2859667 complement(2396023..2396241) 1 NC_002952.2 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 2396241 infA 2859667 infA Staphylococcus aureus subsp. aureus MRSA252 translation initiation factor IF-1 YP_041668.1 2396023 R 282458 CDS YP_041669.1 49484445 2860980 complement(2396434..2397081) 1 NC_002952.2 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 2397081 adk 2860980 adk Staphylococcus aureus subsp. aureus MRSA252 adenylate kinase YP_041669.1 2396434 R 282458 CDS YP_041670.1 49484446 2859137 complement(2397098..2398390) 1 NC_002952.2 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 2398390 secY 2859137 secY Staphylococcus aureus subsp. aureus MRSA252 preprotein translocase subunit SecY YP_041670.1 2397098 R 282458 CDS YP_041671.1 49484447 2860910 complement(2398390..2398830) 1 NC_002952.2 late assembly protein; 50S ribosomal protein L15 2398830 rplO 2860910 rplO Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L15 YP_041671.1 2398390 R 282458 CDS YP_041672.1 49484448 2860924 complement(2398847..2399026) 1 NC_002952.2 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 2399026 rpmD 2860924 rpmD Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L30 YP_041672.1 2398847 R 282458 CDS YP_041673.1 49484449 2860176 complement(2399043..2399543) 1 NC_002952.2 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 2399543 rpsE 2860176 rpsE Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S5 YP_041673.1 2399043 R 282458 CDS YP_041674.1 49484450 2860913 complement(2399564..2399923) 1 NC_002952.2 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 2399923 rplR 2860913 rplR Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L18 YP_041674.1 2399564 R 282458 CDS YP_041675.1 49484451 2860903 complement(2399954..2400490) 1 NC_002952.2 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 2400490 rplF 2860903 rplF Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L6 YP_041675.1 2399954 R 282458 CDS YP_041676.1 49484452 2860179 complement(2400515..2400913) 1 NC_002952.2 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 2400913 rpsH 2860179 rpsH Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S8 YP_041676.1 2400515 R 282458 CDS YP_041677.1 49484453 2861450 complement(2400945..2401130) 1 NC_002952.2 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 2401130 rpsN 2861450 rpsN Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S14 YP_041677.1 2400945 R 282458 CDS YP_041678.1 49484454 2860902 complement(2401153..2401692) 1 NC_002952.2 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 2401692 rplE 2860902 rplE Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L5 YP_041678.1 2401153 R 282458 CDS YP_041679.1 49484455 2860919 complement(2401719..2402036) 1 NC_002952.2 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 2402036 rplX 2860919 rplX Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L24 YP_041679.1 2401719 R 282458 CDS YP_041680.1 49484456 2860909 complement(2402072..2402440) 1 NC_002952.2 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 2402440 rplN 2860909 rplN Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L14 YP_041680.1 2402072 R 282458 CDS YP_041681.1 49484457 2861453 complement(2402472..2402735) 1 NC_002952.2 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 2402735 rpsQ 2861453 rpsQ Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S17 YP_041681.1 2402472 R 282458 CDS YP_041682.1 49484458 2860923 complement(2402759..2402968) 1 NC_002952.2 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 2402968 rpmC 2860923 rpmC Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L29 YP_041682.1 2402759 R 282458 CDS YP_041683.1 49484459 2860911 complement(2402958..2403392) 1 NC_002952.2 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 2403392 rplP 2860911 rplP Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L16 YP_041683.1 2402958 R 282458 CDS YP_041684.1 49484460 2860174 complement(2403395..2404048) 1 NC_002952.2 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 2404048 rpsC 2860174 rpsC Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S3 YP_041684.1 2403395 R 282458 CDS YP_041685.1 49484461 2860917 complement(2404072..2404425) 1 NC_002952.2 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 2404425 rplV 2860917 rplV Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L22 YP_041685.1 2404072 R 282458 CDS YP_041686.1 49484462 2861455 complement(2404454..2404732) 1 NC_002952.2 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 2404732 rpsS 2861455 rpsS Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S19 YP_041686.1 2404454 R 282458 CDS YP_041687.1 49484463 2860899 complement(2404799..2405632) 1 NC_002952.2 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 2405632 rplB 2860899 rplB Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L2 YP_041687.1 2404799 R 282458 CDS YP_041688.1 49484464 2860918 complement(2405665..2405940) 1 NC_002952.2 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 2405940 rplW 2860918 rplW Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L23 YP_041688.1 2405665 R 282458 CDS YP_041689.1 49484465 2860901 complement(2405940..2406563) 1 NC_002952.2 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 2406563 rplD 2860901 rplD Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L4 YP_041689.1 2405940 R 282458 CDS YP_041690.1 49484466 2860900 complement(2406590..2407252) 1 NC_002952.2 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 2407252 rplC 2860900 rplC Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L3 YP_041690.1 2406590 R 282458 CDS YP_041691.1 49484467 2861446 complement(2407280..2407588) 1 NC_002952.2 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 2407588 rpsJ 2861446 rpsJ Staphylococcus aureus subsp. aureus MRSA252 30S ribosomal protein S10 YP_041691.1 2407280 R 282458 CDS YP_041692.1 49484468 2861045 2407939..2408334 1 NC_002952.2 Poor database matches. Weakly similar to the C-terminal region of Lactococcus lactis hypothetical protein YkaC TR:Q9CGW4 (EMBL:AE006332) (213 aa) fasta scores: E(): 6.6, 28.28% id in 99 aa; hypothetical protein 2408334 2861045 SAR2337 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041692.1 2407939 D 282458 CDS YP_041693.1 49484469 2861046 complement(2408527..2409861) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YebB TR:O34987 (EMBL:Z99107) (440 aa) fasta scores: E(): 2e-100, 64.48% id in 442 aa, and to Bacillus halodurans hypothetical protein BH0608 TR:Q9KF77 (EMBL:AP001509) (434 aa) fasta scores: E(): 5.3e-82, 58.4% id in 440 aa; xanthine/uracil permease 2409861 2861046 SAR2338 Staphylococcus aureus subsp. aureus MRSA252 xanthine/uracil permease YP_041693.1 2408527 R 282458 CDS YP_041694.1 49484470 2861047 complement(2409974..2412109) 1 NC_002952.2 decatenates replicating daughter chromosomes; DNA topoisomerase III 2412109 2861047 SAR2339 Staphylococcus aureus subsp. aureus MRSA252 DNA topoisomerase III YP_041694.1 2409974 R 282458 CDS YP_041695.1 49484471 2861048 2412296..2413183 1 NC_002952.2 Poor database matches. Weakly similar to Bacillus halodurans hypothetical protein BH0299 TR:Q9KG16 (EMBL:AP001508) (305 aa) fasta scores: E(): 1.5e-05, 19.72% id in 294 aa; acetyltransferase (GNAT) family protein 2413183 2861048 SAR2340 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_041695.1 2412296 D 282458 CDS YP_041696.1 49484472 2859918 2413364..2414227 1 NC_002952.2 Similar to Staphylococcus xylosus glucose uptake protein GlcU TR:O07881 (EMBL:Y14043) (288 aa) fasta scores: E(): 4.6e-72, 72.53% id in 284 aa, and to Bacillus megaterium hypothetical protein SW:YCXE_BACME (P40419) (286 aa) fasta scores: E(): 2.1e-53, 54.06% id in 283 aa; glucose uptake protein 2414227 glcU 2859918 glcU Staphylococcus aureus subsp. aureus MRSA252 glucose uptake protein YP_041696.1 2413364 D 282458 CDS YP_041697.1 49484473 2861049 complement(2414646..2415554) 1 NC_002952.2 Poor database matches. Similar to Methanococcus jannaschii hypothetical protein MJ1031 SW:YA31_METJA (Q58437) (308 aa) fasta scores: E(): 8.2e-09, 21.45% id in 317 aa, and to Clostridium cellulovorans malate permease Mln TR:Q9LAI9 (EMBL:AF132735) (290 aa) fasta scores: E(): 4.4e-06, 25.08% id in 287 aa; hypothetical protein 2415554 2861049 SAR2342 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041697.1 2414646 R 282458 CDS YP_041698.1 49484474 2861050 2415687..2415851 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans hypothetical protein BH0180 TR:Q9KGC4 (EMBL:AP001507) (59 aa) fasta scores: E(): 7e-05, 46.15% id in 52 aa; hypothetical protein 2415851 2861050 SAR2343 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041698.1 2415687 D 282458 CDS YP_041699.1 49484475 2861051 2416096..2416413 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Drosophila yakuba NADH-ubiquinone oxidoreductase chain 6 ND6 SW:NU6M_DROYA (P07709) (174 aa) fasta scores: E(): 2.3, 24.24% id in 99 aa; hypothetical protein 2416413 2861051 SAR2344 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041699.1 2416096 D 282458 CDS YP_041700.1 49484476 2861052 complement(2416600..2419767) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YerP TR:O31501 (EMBL:Z99107) (1065 aa) fasta scores: E(): 1.2e-160, 46.03% id in 1058 aa, and to Bacillus halodurans cation efflux system protein BH3816 TR:Q9K6B3 (EMBL:AP001520) (1093 aa) fasta scores: E(): 2.4e-57, 26.52% id in 1063 aa; AcrB/AcrD/AcrF family protein 2419767 2861052 SAR2345 Staphylococcus aureus subsp. aureus MRSA252 AcrB/AcrD/AcrF family protein YP_041700.1 2416600 R 282458 CDS YP_041701.1 49484477 2860669 complement(2419884..2421149) 1 NC_002952.2 Similar to Staphylococcus sciuri, peptidoglycan pentaglycine interpeptide biosynthesis protein, essential for methicillin resistance FemA TR:Q9ZFG3 (EMBL:AF099966) (417 aa) fasta scores: E(): 6.4e-20, 25.82% id in 426 aa. Previously sequenced as Staphylococcus aureus peptidoglycan pentaglycine interpeptide biosynthesis protein FmhB TR:Q9X4D7 (EMBL:AF106850) (421 aa) fasta scores: E(): 5.3e-150, 99.28% id in 421 aa; peptidoglycan pentaglycine interpeptide biosynthesis protein 2421149 fmhB 2860669 fmhB Staphylococcus aureus subsp. aureus MRSA252 peptidoglycan pentaglycine interpeptide biosynthesis protein YP_041701.1 2419884 R 282458 CDS YP_041702.1 49484478 2861053 2421538..2421789 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 2421789 2861053 SAR2347 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041702.1 2421538 D 282458 CDS YP_041703.1 49484479 2861054 complement(2421781..2422545) 1 NC_002952.2 Poor database matches. Similar to an internal region of Legionella pneumophila hypothetical protein TR:Q9AKW5 (EMBL:AJ277755) (402 aa) fasta scores: E(): 4.1, 20.07% id in 254 aa; hypothetical protein 2422545 2861054 SAR2348 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041703.1 2421781 R 282458 CDS YP_041704.1 49484480 2861055 2422708..2423148 1 NC_002952.2 Similar to Escherichia coli homoprotocatechuate degradative operon repressor HpcR SW:HPCR_ECOLI (Q07095) (148 aa) fasta scores: E(): 0.0022, 21.42% id in 112 aa, and to Staphylococcus sciuri Orf141 protein TR:O54273 (EMBL:Y13094) (141 aa) fasta scores: E(): 0.00089, 23.94% id in 142 aa; MarR family regulatory protein 2423148 2861055 SAR2349 Staphylococcus aureus subsp. aureus MRSA252 MarR family regulatory protein YP_041704.1 2422708 D 282458 CDS YP_041705.1 49484481 2861056 2423141..2424352 1 NC_002952.2 Similar to Lactococcus lactis transporter YbfD TR:Q9CJ52 (EMBL:AE006253) (393 aa) fasta scores: E(): 1.3e-48, 37.08% id in 391 aa, and to Bacillus subtilis hypothetical protein YwoG TR:P94577 (EMBL:Z82987) (396 aa) fasta scores: E(): 6.8e-38, 32.19% id in 379 aa; transporter protein 2424352 2861056 SAR2350 Staphylococcus aureus subsp. aureus MRSA252 transporter protein YP_041705.1 2423141 D 282458 CDS YP_041706.1 49484482 2861057 complement(2424454..2424804) 1 NC_002952.2 Similar to Staphylococcus aureus staphylococcal accessory regulator A SarA TR:Q53600 (EMBL:U20782) (124 aa) fasta scores: E(): 0.27, 27.83% id in 97 aa, and to Staphylococcus epidermidis staphylococcal accessory regulator A homologue SarA TR:O85233 (EMBL:AF054173) (124 aa) fasta scores: E(): 0.11, 26.88% id in 93 aa; hypothetical protein 2424804 2861057 SAR2351 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041706.1 2424454 R 282458 CDS YP_041707.1 49484483 2861173 complement(2425381..2426403) 1 NC_002952.2 Similar to Bacillus subtilis molybdenum cofactor biosynthesis protein A MoaA SW:MOAA_BACSU (P39757) (341 aa) fasta scores: E(): 4e-64, 49.85% id in 339 aa, and to Staphylococcus carnosus molybdenum cofactor biosynthesis protein A MoaA SW:MOAA_STACA (Q9ZIM6) (340 aa) fasta scores: E(): 7.7e-111, 83.82% id in 340 aa; molybdenum cofactor biosynthesis protein A 2426403 moaA 2861173 moaA Staphylococcus aureus subsp. aureus MRSA252 molybdenum cofactor biosynthesis protein A YP_041707.1 2425381 R 282458 CDS YP_041708.1 49484484 2861299 complement(2426423..2427022) 1 NC_002952.2 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 2427022 mobA 2861299 mobA Staphylococcus aureus subsp. aureus MRSA252 molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_041708.1 2426423 R 282458 CDS YP_041709.1 49484485 2861297 complement(2427029..2427262) 1 NC_002952.2 Similar to Homo sapiens molybdopterin-synthase small subunit MOCO1-B TR:O96033 (EMBL:AF091871) (88 aa) fasta scores: E(): 0.00015, 34.14% id in 82 aa, and to Staphylococcus carnosus MoaD protein TR:Q9ZIM8 (EMBL:AF109295) (77 aa) fasta scores: E(): 5.4e-15, 59.74% id in 77 aa; molybdopterin-synthase small subunit 2427262 moaD 2861297 moaD Staphylococcus aureus subsp. aureus MRSA252 molybdopterin-synthase small subunit YP_041709.1 2427029 R 282458 CDS YP_041710.1 49484486 2861298 complement(2427268..2427714) 1 NC_002952.2 Similar to Homo sapiens molybdopterin-synthase large subunit MOCO1-A TR:O96007 (EMBL:AF091871) (188 aa) fasta scores: E(): 1.2e-16, 40% id in 130 aa, and to Staphylococcus carnosus MoaE protein TR:Q9ZIM9 (EMBL:AF109295) (150 aa) fasta scores: E(): 4.1e-49, 84.72% id in 144 aa; molybdopterin-synthase large subunit 2427714 moaE 2861298 moaE Staphylococcus aureus subsp. aureus MRSA252 molybdopterin-synthase large subunit YP_041710.1 2427268 R 282458 CDS YP_041711.1 49484487 2861300 complement(2427728..2428213) 1 NC_002952.2 Similar to Escherichia coli molybdopterin-guanine dinucleotide biosynthesis protein B MobB SW:MOBB_ECOLI (P32125) (174 aa) fasta scores: E(): 0.00063, 27.96% id in 118 aa, and to Staphylococcus carnosus MobB protein TR:Q9ZIN0 (EMBL:AF109295) (160 aa) fasta scores: E(): 1.1e-29, 57.96% id in 157 aa; molybdopterin-guanine dinucleotide biosynthesis protein B 2428213 mobB 2861300 mobB Staphylococcus aureus subsp. aureus MRSA252 molybdopterin-guanine dinucleotide biosynthesis protein B YP_041711.1 2427728 R 282458 CDS YP_041712.1 49484488 2861304 complement(2428210..2429469) 1 NC_002952.2 Similar to Clostridium perfringens molybdenum cofactor biosynthesis protein MoeA TR:Q9WX93 (EMBL:AB017192) (406 aa) fasta scores: E(): 9.7e-44, 36.25% id in 400 aa, and to Staphylococcus carnosus MoeA protein TR:Q9ZIN1 (EMBL:AF109295) (419 aa) fasta scores: E(): 1.5e-112, 74.7% id in 419 aa; molybdenum cofactor biosynthesis protein 2429469 moeA 2861304 moeA Staphylococcus aureus subsp. aureus MRSA252 molybdenum cofactor biosynthesis protein YP_041712.1 2428210 R 282458 CDS YP_041713.1 49484489 2861296 2429532..2430026 1 NC_002952.2 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 2430026 moaC 2861296 moaC Staphylococcus aureus subsp. aureus MRSA252 molybdenum cofactor biosynthesis protein MoaC YP_041713.1 2429532 D 282458 CDS YP_041714.1 49484490 2861174 complement(2430028..2430534) 1 NC_002952.2 Similar to Escherichia coli molybdenum cofactor biosynthesis protein B MoaB SW:MOAB_ECOLI (P30746) (169 aa) fasta scores: E(): 4.4e-18, 44.59% id in 148 aa, and to Staphylococcus carnosus MoaB protein TR:Q9ZIN3 (EMBL:AF109295) (170 aa) fasta scores: E(): 9.2e-45, 77.1% id in 166 aa; molybdenum cofactor biosynthesis protein B 2430534 moaB 2861174 moaB Staphylococcus aureus subsp. aureus MRSA252 molybdenum cofactor biosynthesis protein B YP_041714.1 2430028 R 282458 CDS YP_041715.1 49484491 2861305 complement(2430563..2431567) 1 NC_002952.2 Similar to Staphylococcus carnosus molybdopterin synthase sulfurylase MoeB TR:Q9ZIN4 (EMBL:AF109295) (333 aa) fasta scores: E(): 3.9e-92, 68.58% id in 331 aa. N-terminal region to Escherichia coli adenylyltransferase ThiF SW:THIF_ECOLI (P30138) (251 aa) fasta scores: E(): 8e-18, 33.73% id in 249 aa; molybdopterin synthase sulfurylase 2431567 moeB 2861305 moeB Staphylococcus aureus subsp. aureus MRSA252 molybdopterin synthase sulfurylase YP_041715.1 2430563 R 282458 CDS YP_041716.1 49484492 2861303 complement(2431735..2432340) 1 NC_002952.2 Similar to the N-terminal region of Escherichia coli molybdenum transport ATP-binding protein ModC SW:MODC_ECOLI (P09833) (352 aa) fasta scores: E(): 2e-19, 38.61% id in 202 aa, and to the full length Staphylococcus carnosus ModC protein TR:Q9ZIN5 (EMBL:AF109295) (202 aa) fasta scores: E(): 2.9e-48, 74.62% id in 201 aa; molybdenum transport ATP-binding protein 2432340 modC 2861303 modC Staphylococcus aureus subsp. aureus MRSA252 molybdenum transport ATP-binding protein YP_041716.1 2431735 R 282458 CDS YP_041717.1 49484493 2861302 complement(2432341..2433012) 1 NC_002952.2 Similar to Escherichia coli molybdenum ABC transporter permease ModB SW:MODB_ECOLI (P09834) (229 aa) fasta scores: E(): 6.7e-21, 35.26% id in 207 aa, and to Staphylococcus carnosus ModB protein TR:Q9ZIN6 (EMBL:AF109295) (223 aa) fasta scores: E(): 7.9e-69, 81.16% id in 223 aa; molybdenum ABC transporter permease 2433012 modB 2861302 modB Staphylococcus aureus subsp. aureus MRSA252 molybdenum ABC transporter permease YP_041717.1 2432341 R 282458 CDS YP_041718.1 49484494 2861301 complement(2433026..2433808) 1 NC_002952.2 Similar to Rhodobacter capsulatus molybdate-binding periplasmic protein precursor ModA SW:MODA_RHOCA (Q08383) (252 aa) fasta scores: E(): 1.4e-08, 26.99% id in 226 aa, and to Staphylococcus carnosus ModA protein TR:Q9ZIN7 (EMBL:AF109295) (261 aa) fasta scores: E(): 4.4e-60, 69.61% id in 260 aa; molybdate-binding lipoprotein precursor 2433808 modA 2861301 modA Staphylococcus aureus subsp. aureus MRSA252 molybdate-binding lipoprotein precursor YP_041718.1 2433026 R 282458 CDS YP_041719.1 49484495 2861058 2434098..2434895 1 NC_002952.2 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 2434895 2861058 SAR2364 Staphylococcus aureus subsp. aureus MRSA252 formate dehydrogenase accessory protein YP_041719.1 2434098 D 282458 CDS YP_041720.1 49484496 2861059 complement(2435066..2435836) 1 NC_002952.2 Poor database matches. Weakly similar to Bacillus subtilis hypothetical protein that possibly influences maturation of the outermost layer of the spore, CgeE SW:CGEE_BACSU (P42093) (259 aa) fasta scores: E(): 0.65, 20.96% id in 229 aa; acetyltransferase (GNAT) family protein 2435836 2861059 SAR2365 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_041720.1 2435066 R 282458 CDS YP_041721.1 49484497 2861060 complement(2435908..2436462) 1 NC_002952.2 Similar to Bacillus sphaericus biotin synthase BioY SW:BIOY_BACSH (P22819) (196 aa) fasta scores: E(): 1.2e-07, 30% id in 180 aa, and to Lactococcus lactis hypothetical protein YseA TR:Q9CEQ5 (EMBL:AE006408) (189 aa) fasta scores: E(): 8.6e-21, 43.75% id in 176 aa; BioY family protein 2436462 2861060 SAR2366 Staphylococcus aureus subsp. aureus MRSA252 BioY family protein YP_041721.1 2435908 R 282458 CDS YP_041722.1 49484498 2861061 complement(2436583..2437524) 1 NC_002952.2 Similar to Trypanosoma brucei brucei inosine-adenosine-guanosine-nucleoside hydrolase TR:O15727 (EMBL:AF017231) (327 aa) fasta scores: E(): 2.8e-16, 31.28% id in 326 aa, and to Trypanosoma vivax iag-nucleoside hydrolase TR:Q9GPQ4 (EMBL:AF311701) (327 aa) fasta scores: E(): 7.3e-18, 31.9% id in 326 aa; inosine-uridine preferring nucleoside hydrolase 2437524 2861061 SAR2367 Staphylococcus aureus subsp. aureus MRSA252 inosine-uridine preferring nucleoside hydrolase YP_041722.1 2436583 R 282458 CDS YP_041723.1 49484499 2861062 complement(2437923..2438831) 1 NC_002952.2 Similar to Bacillus subtilis ferrichrome-binding protein precursor FhuD SW:FHUD_BACSU (P37580) (315 aa) fasta scores: E(): 1.1e-31, 37.82% id in 312 aa, and to Streptococcus pyogenes ferrichrome ABC transporter SPY0385 TR:Q9A198 (EMBL:AE006501) (310 aa) fasta scores: E(): 8.4e-34, 37.74% id in 310 aa; ferrichrome-binding lipoprotein precursor 2438831 2861062 SAR2368 Staphylococcus aureus subsp. aureus MRSA252 ferrichrome-binding lipoprotein precursor YP_041723.1 2437923 R 282458 CDS YP_041724.1 49484500 2861063 complement(2439044..2440198) 1 NC_002952.2 Similar to Clostridium acetobutylicum short-chain specific acyl-CoA dehydrogenase Bcd SW:ACDS_CLOAB (P52042) (379 aa) fasta scores: E(): 7.5e-14, 22.4% id in 366 aa, and to Bacillus subtilis hypothetical protein YdbM TR:P96608 (EMBL:AB001488) (381 aa) fasta scores: E(): 9.4e-71, 48.93% id in 374 aa; hypothetical protein 2440198 2861063 SAR2369 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041724.1 2439044 R 282458 CDS YP_041725.1 49484501 2861064 complement(2440245..2440337) 1 NC_002952.2 Doubtful CDS. No significant database matches; hypothetical protein 2440337 2861064 SAR2370 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041725.1 2440245 R 282458 CDS YP_041726.1 49484502 2859823 complement(2440413..2441318) 1 NC_002952.2 Similar to internal regions of Homo sapiens erythrocyte urea transporter UT1 SW:UT1_HUMAN (Q13336) (389 aa) fasta scores: E(): 7.2e-17, 27.15% id in 302 aa, and Oryctolagus cuniculus kidney urea transporter UT2 SW:UT2_RABIT (Q28614) (397 aa) fasta scores: E(): 1.2e-15, 26.78% id in 295 aa; hypothetical protein 2441318 2859823 SAR2371 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041726.1 2440413 R 282458 CDS YP_041727.1 49484503 2860416 2441578..2441880 1 NC_002952.2 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 2441880 ureA 2860416 ureA Staphylococcus aureus subsp. aureus MRSA252 urease subunit gamma YP_041727.1 2441578 D 282458 CDS YP_041728.1 49484504 2860417 2441894..2442304 1 NC_002952.2 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Staphylococcus saprophyticus plays a role in bladder invasiveness and may induce the formation of kidney and bladder stones due to the alkalization of urine; urease subunit beta 2442304 ureB 2860417 ureB Staphylococcus aureus subsp. aureus MRSA252 urease subunit beta YP_041728.1 2441894 D 282458 CDS YP_041729.1 49484505 2860418 2442301..2444016 1 NC_002952.2 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 2444016 ureC 2860418 ureC Staphylococcus aureus subsp. aureus MRSA252 urease subunit alpha YP_041729.1 2442301 D 282458 CDS YP_041730.1 49484506 2860420 2444029..2444481 1 NC_002952.2 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 2444481 ureE 2860420 ureE Staphylococcus aureus subsp. aureus MRSA252 urease accessory protein UreE YP_041730.1 2444029 D 282458 CDS YP_041731.1 49484507 2860421 2444474..2445163 1 NC_002952.2 Similar to Bacillus sp urease accessory protein UreF SW:UREF_BACSB (Q07402) (227 aa) fasta scores: E(): 3.5e-39, 44.39% id in 223 aa. N-terminus is similar to Staphylococcus xylosus urease accessory protein UreF SW:UREF_STAXY (P42876) (189 aa) fasta scores: E(): 3.9e-61, 78.19% id in 188 aa; urease accessory protein UreF 2445163 ureF 2860421 ureF Staphylococcus aureus subsp. aureus MRSA252 urease accessory protein UreF YP_041731.1 2444474 D 282458 CDS YP_041732.1 49484508 2860422 2445176..2445790 1 NC_002952.2 Similar to Staphylococcus xylosus urease accessory protein UreG SW:UREG_STAXY (P42877) (204 aa) fasta scores: E(): 2.1e-63, 89.7% id in 204 aa, and to Bacillus sp urease accessory protein UreG SW:UREG_BACSB (Q07403) (204 aa) fasta scores: E(): 8.1e-52, 75% id in 200 aa; urease accessory protein UreG 2445790 ureG 2860422 ureG Staphylococcus aureus subsp. aureus MRSA252 urease accessory protein UreG YP_041732.1 2445176 D 282458 CDS YP_041733.1 49484509 2860419 2445790..2446626 1 NC_002952.2 Similar to Bacillus sp urease accessory protein UreD SW:URED_BACSB (Q07400) (271 aa) fasta scores: E(): 1.8e-32, 34.19% id in 272 aa, and to Ureaplasma urealyticum urease complex component UreD TR:Q9FA29 (EMBL:AF085731) (287 aa) fasta scores: E(): 2.4e-26, 29.13% id in 278 aa; urease accessory protein UreD 2446626 ureD 2860419 ureD Staphylococcus aureus subsp. aureus MRSA252 urease accessory protein UreD YP_041733.1 2445790 D 282458 CDS YP_041734.1 49484510 2861467 complement(2446815..2447162) 1 NC_002952.2 Similar to Staphylococcus aureus staphylococcal accessory regulator A SarA TR:Q53600 (EMBL:U20782) (124 aa) fasta scores: E(): 1.9e-05, 30.08% id in 113 aa. Previously sequenced as Staphylococcus aureus taphylococcal accessory regulator A homologue SarR TR:Q9F0R1 (EMBL:AF207701) (115 aa) fasta scores: E(): 2.5e-37, 100% id in 115 aa; accessory regulator A 2447162 sarR 2861467 sarR Staphylococcus aureus subsp. aureus MRSA252 accessory regulator A YP_041734.1 2446815 R 282458 CDS YP_041735.1 49484511 2858996 complement(2447590..2447916) 1 NC_002952.2 Poor database matches. Similar to Staphylococcus xylosus hypothetical protein TR:Q9EV51 (EMBL:AJ295151) (108 aa) fasta scores: E(): 2.2e-22, 55.76% id in 104 aa; hypothetical protein 2447916 2858996 SAR2380 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041735.1 2447590 R 282458 CDS YP_041736.1 49484512 2858997 complement(2447980..2448723) 1 NC_002952.2 Poor database matches. N-terminal region is similar to Staphylococcus aureus staphylococcal accessory regulator A homologue SarR TR:Q9F0R1 (EMBL:AF207701) (115 aa) fasta scores: E(): 3, 24.57% id in 118 aa. Similar to the full length Staphylococcus aureus rot-like protein Rlp TR:Q9EZK4 (EMBL:AF288788) (247 aa) fasta scores: E(): 0.41, 25.84% id in 236 aa; hypothetical protein 2448723 2858997 SAR2381 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041736.1 2447980 R 282458 CDS YP_041737.1 49484513 2858998 complement(2448749..2450704) 1 NC_002952.2 No significant database matches to the full length CDS. N-terminus is similar to Bacillus halodurans transcriptional regulator BH0711 TR:Q9KEY8 (EMBL:AP001509) (263 aa) fasta scores: E(): 0.018, 22.43% id in 263 aa, and Lactococcus lactis xylose regulatory protein XylR TR:Q9RAV4 (EMBL:AF092040) (316 aa) fasta scores: E(): 0.024, 20.35% id in 285 aa; transcriptional regulator 2450704 2858998 SAR2382 Staphylococcus aureus subsp. aureus MRSA252 transcriptional regulator YP_041737.1 2448749 R 282458 CDS YP_041738.1 49484514 2858999 2451314..2452123 1 NC_002952.2 Similar to Staphylococcus carnosus major secreted protein SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 2.3e-57, 65.81% id in 275 aa, and to Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 6.3e-48, 72.89% id in 273 aa. Similar to SAR2648, 75.093% identity (79.216% ungapped) in 269 aa overlap. C-terminal region is similar to SAR2388, 63.077% identity (65.079% ungapped) in 130 aa overlap; hypothetical protein 2452123 2858999 SAR2383 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041738.1 2451314 D 282458 CDS YP_041739.1 49484515 2859000 complement(2452192..2452386) 1 NC_002952.2 Doubtful CDS. No significant database matches; hypothetical protein 2452386 2859000 SAR2384 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041739.1 2452192 R 282458 CDS YP_041740.1 49484516 2859001 complement(2452560..2453960) 1 NC_002952.2 Similar to Bacillus firmus Na+/H+ antiporter NhaC SW:NHAC_BACFI (P27611) (462 aa) fasta scores: E(): 4.8e-47, 31.25% id in 464 aa, and to Haemophilus influenzae hypothetical Na+/H+ antiporter HI1107 SW:YB07_HAEIN (Q57007) (468 aa) fasta scores: E(): 1.5e-63, 36.16% id in 459 aa; Na+/H+ antiporter 2453960 2859001 SAR2385 Staphylococcus aureus subsp. aureus MRSA252 Na+/H+ antiporter YP_041740.1 2452560 R 282458 CDS YP_041741.1 49484517 2859002 complement(2454055..2455137) 1 NC_002952.2 Similar to Arthrobacter sp opine dehydrogenase Odh SW:ODH_ARTSP (Q44297) (359 aa) fasta scores: E(): 1.4e-22, 26.68% id in 356 aa, and to Agrobacterium vitis vitopine synthase Vis SW:VIS_AGRVI (Q04554) (360 aa) fasta scores: E(): 4.6e-10, 24.15% id in 356 aa; dehydrogenase 2455137 2859002 SAR2386 Staphylococcus aureus subsp. aureus MRSA252 dehydrogenase YP_041741.1 2454055 R 282458 CDS YP_041742.1 49484518 2859003 2455385..2455807 1 NC_002952.2 Poor database matches. Weak similarity to Pseudomonas aeruginosa hypothetical protein PA5333 TR:Q9HTM4 (EMBL:AE004946) (123 aa) fasta scores: E(): 0.0059, 30.28% id in 142 aa, and to Synechocystis sp hypothetical protein SLR0686 TR:P72954 (EMBL:D90902) (119 aa) fasta scores: E(): 7e-05, 35.29% id in 136 aa; hypothetical protein 2455807 2859003 SAR2387 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041742.1 2455385 D 282458 CDS YP_041743.1 49484519 2859004 2456044..2456535 1 NC_002952.2 Similar to the C-terminal regions of Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 1.5e-27, 59.12% id in 137 aa, andStaphylococcus carnosus major secreted protein SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 1.8e-27, 58.08% id in 136 aa. Similar to the C-terminal regions of SAR2383, 63.077% identity (65.079% ungapped) in 130 aa overlap, and SAR2648, 60.769% identity (62.698% ungapped) in 130 aa overlap; hypothetical protein 2456535 2859004 SAR2388 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041743.1 2456044 D 282458 CDS YP_041744.1 49484520 2859005 2456894..2457847 1 NC_002952.2 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; glycerate dehydrogenase 2457847 2859005 SAR2389 Staphylococcus aureus subsp. aureus MRSA252 glycerate dehydrogenase YP_041744.1 2456894 D 282458 CDS YP_041745.1 49484521 2859006 complement(2457939..2459063) 1 NC_002952.2 Similar to Streptomyces coelicolor monooxygenase 2SCG61.20c TR:Q9K3Z5 (EMBL:AL359949) (396 aa) fasta scores: E(): 1.9e-22, 29.58% id in 365 aa, and to Pseudomonas aeruginosa probable FAD-dependent monooxygenase PA3328 TR:Q9HYR7 (EMBL:AE004755) (388 aa) fasta scores: E(): 2.4e-20, 25.72% id in 381 aa; hypothetical protein 2459063 2859006 SAR2390 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041745.1 2457939 R 282458 CDS YP_041746.1 49484522 2859007 complement(2459728..2460504) 1 NC_002952.2 Similar to the C-terminal regions of Staphylococcus aureus bifunctional autolysin precursor [includes: N-acetylmuramoyl-L-alanine amidase; mannosyl-glycoprotein endo-beta-N-acetylglucosamidase] Atl SW:ATL_STAAU (P52081) (1256 aa) fasta scores: E(): 1.8e-24, 39.55% id in 225 aa, and Bacillus subtilis beta-N-acetylglucosaminidase precursor LytD SW:LYTD_BACSU (P39848) (880 aa) fasta scores: E(): 8.3e-22, 43.24% id in 185 aa; N-acetylmuramoyl-L-alanine amidase 2460504 2859007 SAR2391 Staphylococcus aureus subsp. aureus MRSA252 N-acetylmuramoyl-L-alanine amidase YP_041746.1 2459728 R 282458 CDS YP_041747.1 49484523 2859008 complement(2460526..2460777) 1 NC_002952.2 hypothetical protein 2460777 2859008 SAR2391a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041747.1 2460526 R 282458 CDS YP_041748.1 49484524 2859009 complement(2461053..2461526) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YrhD SW:YRHD_BACSU (O05396) (160 aa) fasta scores: E(): 2.9e-07, 28.66% id in 157 aa, and to Bacillus subtilis hypothetical protein YjgD TR:O34681 (EMBL:AF015825) (186 aa) fasta scores: E(): 3.5e-06, 26.11% id in 157 aa; hypothetical protein 2461526 2859009 SAR2392 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041748.1 2461053 R 282458 CDS YP_041749.1 49484525 2859010 complement(2461526..2464480) 1 NC_002952.2 C-terminal region is similar to Escherichia coli formate dehydrogenase H FdhF SW:FDHF_ECOLI (P07658) (715 aa) fasta scores: E(): 2.7e-78, 35.15% id in 697 aa. Full length CDS similar to Bacillus subtilis formate dehydrogenase alpha subunit homologue YjgC TR:O34720 (EMBL:AF015825) (985 aa) fasta scores: E(): 0, 59.34% id in 979 aa; bifunctional protein GlmU 2464480 2859010 SAR2393 Staphylococcus aureus subsp. aureus MRSA252 bifunctional protein GlmU YP_041749.1 2461526 R 282458 CDS YP_041750.1 49484526 2859011 complement(2465082..2466029) 1 NC_002952.2 Similar to Bacillus subtilis membrane-bound attenuator of lytABC and lytR expression LytR SW:LYTR_BACSU (Q02115) (306 aa) fasta scores: E(): 1.5e-40, 40% id in 315 aa, and to Bacillus halodurans attenuator of lytABC and lytR expression BH3670 TR:Q9K6Q8 (EMBL:AP001519) (304 aa) fasta scores: E(): 3.3e-38, 37.91% id in 298 aa; hypothetical protein 2466029 2859011 SAR2394 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041750.1 2465082 R 282458 CDS YP_041751.1 49484527 2859012 complement(2466162..2466959) 1 NC_002952.2 Similar to Escherichia coli extragenic suppressor protein SuhB SW:SUHB_ECOLI (P22783) (267 aa) fasta scores: E(): 1.8e-13, 28.19% id in 227 aa, and to Bacillus subtilis extragenic suppressor protein SuhB homologue SW:SUHB_BACSU (Q45499) (265 aa) fasta scores: E(): 8.2e-21, 30.76% id in 260 aa; inositol monophosphatase 2466959 2859012 SAR2395 Staphylococcus aureus subsp. aureus MRSA252 inositol monophosphatase YP_041751.1 2466162 R 282458 CDS YP_041752.1 49484528 2859013 2467344..2468036 1 NC_002952.2 Similar to the N-terminal regions of Bacillus halodurans BH1889 TR:Q9KBN6 (EMBL:AP001513) (325 aa) fasta scores: E(): 5.9e-11, 23.47% id in 230 aa, and to Bacillus subtilis transcription regulator YobV TR:O34920 (EMBL:AF027868) (313 aa) fasta scores: E(): 0.0019, 22.76% id in 224 aa; DeoR family regulatory protein 2468036 2859013 SAR2396 Staphylococcus aureus subsp. aureus MRSA252 DeoR family regulatory protein YP_041752.1 2467344 D 282458 CDS YP_041753.1 49484529 2859014 complement(2468061..2468798) 1 NC_002952.2 Poor database matches. Similar to Bacillus anthracis plasmid pXO2 hypothetical protein pXO2-46 TR:Q9RMY6 (EMBL:AF188935) (221 aa) fasta scores: E(): 2.7e-07, 28.11% id in 217 aa, and to Bacillus halodurans hypothetical protein BH0560 TR:Q9KFC4 (EMBL:AP001508) (237 aa) fasta scores: E(): 1.9e-06, 26% id in 223 aa; hypothetical protein 2468798 2859014 SAR2397 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041753.1 2468061 R 282458 CDS YP_041754.1 49484530 2859015 2468847..2469176 1 NC_002952.2 Poor database matches. Similar to an internal region of Mycoplasma mycoides subsp. mycoides glycerol transporter subunit A GtsA TR:Q9F0F4 (EMBL:AF251037) (406 aa) fasta scores: E(): 4, 29.09% id in 110 aa; hypothetical protein 2469176 2859015 SAR2398 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041754.1 2468847 D 282458 CDS YP_041755.1 49484531 2859016 2469621..2470493 1 NC_002952.2 Similar to Lactococcus lactis transcription regulator YleF TR:Q9CGG3 (EMBL:AE006345) (283 aa) fasta scores: E(): 3.6e-25, 31.15% id in 276 aa, and to Thermotoga maritima hypothetical protein TM0326 SW:Y326_THEMA (Q9WYG1) (280 aa) fasta scores: E(): 3.8e-19, 27.85% id in 280 aa. Similar to SAR0194, 54.639% identity (54.828% ungapped) in 291 aa overlap; transcriptional regulator 2470493 2859016 SAR2399 Staphylococcus aureus subsp. aureus MRSA252 transcriptional regulator YP_041755.1 2469621 D 282458 CDS YP_041756.1 49484532 2859017 complement(2470876..2472255) 1 NC_002952.2 Similar to Salmonella typhimurium proline-specific permease ProY SW:PROY_SALTY (P37460) (456 aa) fasta scores: E(): 4.9e-75, 46.05% id in 456 aa, and to Bacillus subtilis hypothetical transport protein YbxG SW:YBXG_BACSU (P54425) (462 aa) fasta scores: E(): 8.1e-113, 68.81% id in 449 aa; amino acid permease 2472255 2859017 SAR2400 Staphylococcus aureus subsp. aureus MRSA252 amino acid permease YP_041756.1 2470876 R 282458 CDS YP_041757.1 49484533 2859018 2472535..2472891 1 NC_002952.2 Poor database matches; hypothetical protein 2472891 2859018 SAR2401 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041757.1 2472535 D 282458 CDS YP_041758.1 49484534 2859019 2472888..2473073 1 NC_002952.2 Poor database matches. Similar to Streptococcus pneumoniae hypothetical protein Orf24 TR:Q9EZG8 (EMBL:AF295925) (77 aa) fasta scores: E(): 9.8, 35.59% id in 59 aa; hypothetical protein 2473073 2859019 SAR2402 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041758.1 2472888 D 282458 CDS YP_041759.1 49484535 2859020 complement(2473169..2473360) 1 NC_002952.2 Poor database matches; hypothetical protein 2473360 2859020 SAR2403 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041759.1 2473169 R 282458 CDS YP_041760.1 49484536 2859021 complement(2473371..2474006) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhcW SW:YHCW_BACSU (P54607) (220 aa) fasta scores: E(): 6.1e-15, 33.83% id in 201 aa, and to Deinococcus radiodurans CbbY/CbbZ/GpH/YieH family hydrolase DR2613 TR:Q9RR83 (EMBL:AE002090) (238 aa) fasta scores: E(): 4.3e-15, 34.73% id in 190 aa; haloacid dehalogenase-like hydrolase 2474006 2859021 SAR2404 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_041760.1 2473371 R 282458 CDS YP_041761.1 49484537 2859023 2475266..2475796 1 NC_002952.2 hypothetical protein 2475796 2859023 SAR2407 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041761.1 2475266 D 282458 CDS YP_041762.1 49484538 2859024 complement(2475862..2477466) 1 NC_002952.2 Similar to Bacillus subtilis PTS system, arbutin-like IIBC component GlvC SW:PTIB_BACSU (P54715) (527 aa) fasta scores: E(): 2.4e-119, 56.43% id in 528 aa, and to Escherichia coli PTS system, arbutin-like IIC component GlvC SW:PTIC_ECOLI (P31452) (368 aa) fasta scores: E(): 2e-77, 55.31% id in 367 aa; PTS system, arbutin-like IIBC component 2477466 2859024 SAR2408 Staphylococcus aureus subsp. aureus MRSA252 PTS system, arbutin-like IIBC component YP_041762.1 2475862 R 282458 CDS YP_041763.1 49484539 2859025 2477797..2478561 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfiA SW:YFIA_BACSU (P54717) (254 aa) fasta scores: E(): 1e-26, 35.77% id in 246 aa, and to Bacillus halodurans hypothetical protein BH0181 TR:Q9KGC3 (EMBL:AP001507) (241 aa) fasta scores: E(): 2.3e-09, 28.34% id in 247 aa; transcriptional regulator 2478561 2859025 SAR2409 Staphylococcus aureus subsp. aureus MRSA252 transcriptional regulator YP_041763.1 2477797 D 282458 CDS YP_041764.1 49484540 2859026 complement(2478619..2479125) 1 NC_002952.2 hypothetical protein 2479125 2859026 SAR2410 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041764.1 2478619 R 282458 CDS YP_041765.1 49484541 2859027 complement(2479295..2480671) 1 NC_002952.2 Similar to Bacillus firmus Na+/H+ antiporter NhaC SW:NHAC_BACFI (P27611) (462 aa) fasta scores: E(): 3.9e-07, 25.39% id in 449 aa, and to Vibrio cholerae Na+/H+ antiporter VCA0193 TR:Q9KMX3 (EMBL:AE004359) (447 aa) fasta scores: E(): 5.4e-60, 43.54% id in 434 aa. Possible alternative translational start site; transporter 2480671 2859027 SAR2411 Staphylococcus aureus subsp. aureus MRSA252 transporter YP_041765.1 2479295 R 282458 CDS YP_041766.1 49484542 2859028 complement(2480830..2481399) 1 NC_002952.2 hypothetical protein 2481399 2859028 SAR2412 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041766.1 2480830 R 282458 CDS YP_041767.1 49484543 2859029 complement(2481886..2482767) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical oxidoreductase YhxD SW:YHXD_BACSU (P40398) (299 aa) fasta scores: E(): 1.1e-63, 60.9% id in 289 aa, and to Escherichia coli hypothetical oxidoreductase YghA TR:AAG58139 (EMBL:U28377) (294 aa) fasta scores: E(): 5.5e-63, 59.79% id in 286 aa; short chain dehydrogenase 2482767 2859029 SAR2413 Staphylococcus aureus subsp. aureus MRSA252 short chain dehydrogenase YP_041767.1 2481886 R 282458 CDS YP_041768.1 49484544 2859651 complement(2484274..2485512) 1 NC_002952.2 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; imidazolonepropionase 2485512 hutI 2859651 hutI Staphylococcus aureus subsp. aureus MRSA252 imidazolonepropionase YP_041768.1 2484274 R 282458 CDS YP_041769.1 49484545 2859652 complement(2485512..2487173) 1 NC_002952.2 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism; urocanate hydratase 2487173 hutU 2859652 hutU Staphylococcus aureus subsp. aureus MRSA252 urocanate hydratase YP_041769.1 2485512 R 282458 CDS YP_041770.1 49484546 2859031 2487333..2488217 1 NC_002952.2 Similar to Bacillus subtilis als operon regulatory protein AlsR SW:ALSR_BACSU (Q04778) (302 aa) fasta scores: E(): 9.3e-14, 24.15% id in 294 aa, and to Bacillus halodurans transcriptional regulator BH3925 TR:Q9K610 (EMBL:AP001520) (289 aa) fasta scores: E(): 2.5e-14, 25.51% id in 290 aa; LysR family regulatory protein 2488217 2859031 SAR2418 Staphylococcus aureus subsp. aureus MRSA252 LysR family regulatory protein YP_041770.1 2487333 D 282458 CDS YP_041771.1 49484547 2860680 2488459..2488878 1 NC_002952.2 catalyzes resistance to fosfomycin by the addition of a thiol cofactor; fosfomycin resistance protein FosB 2488878 fosB 2860680 fosB Staphylococcus aureus subsp. aureus MRSA252 fosfomycin resistance protein FosB YP_041771.1 2488459 D 282458 CDS YP_041772.1 49484548 2859032 complement(2489134..2490069) 1 NC_002952.2 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate; formimidoylglutamase 2490069 2859032 SAR2420 Staphylococcus aureus subsp. aureus MRSA252 formimidoylglutamase YP_041772.1 2489134 R 282458 CDS YP_041773.1 49484549 2859033 2490347..2491606 1 NC_002952.2 hypothetical protein 2491606 2859033 SAR2421 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041773.1 2490347 D 282458 CDS YP_041774.1 49484550 2859034 complement(2491672..2492358) 1 NC_002952.2 catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 2492358 2859034 SAR2422 Staphylococcus aureus subsp. aureus MRSA252 ribose-5-phosphate isomerase A YP_041774.1 2491672 R 282458 CDS YP_041775.1 49484551 2859035 2492529..2493182 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YflK TR:O34542 (EMBL:Z99108) (221 aa) fasta scores: E(): 3.9e-22, 35.81% id in 215 aa, and to Escherichia coli hypothetical protein YiiM SW:YIIM_ECOLI (P32157) (234 aa) fasta scores: E(): 8e-19, 34.13% id in 208 aa; hypothetical protein 2493182 2859035 SAR2423 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041775.1 2492529 D 282458 CDS YP_041776.1 49484552 2859036 complement(2493418..2494437) 1 NC_002952.2 Similar to Haemophilus influenzae aldose 1-epimerase GalM SW:GALM_HAEIN (P31765) (340 aa) fasta scores: E(): 1.8e-17, 29.76% id in 336 aa, and to Lactococcus lactis aldose 1-epimerase GalM TR:Q9CE62 (EMBL:AE006428) (339 aa) fasta scores: E(): 5.1e-32, 34.09% id in 349 aa; aldose 1-epimerase 2494437 2859036 SAR2424 Staphylococcus aureus subsp. aureus MRSA252 aldose 1-epimerase YP_041776.1 2493418 R 282458 CDS YP_041777.1 49484553 2859037 complement(2494467..2494793) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2744 TR:Q9K9A5 (EMBL:AP001516) (108 aa) fasta scores: E(): 7.1e-23, 61.68% id in 107 aa, and to Bacillus subtilis hypothetical protein YfjF SW:YFJF_BACSU (O31553) (109 aa) fasta scores: E(): 1.1e-22, 57.94% id in 107 aa; hypothetical protein 2494793 2859037 SAR2425 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041777.1 2494467 R 282458 CDS YP_041778.1 49484554 2859350 complement(2495011..2496243) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhaP SW:YHAP_BACSU (O07523) (419 aa) fasta scores: E(): 3.9e-36, 32.93% id in 419 aa, and to Bacillus firmus hypothetical protein NatB TR:O87565 (EMBL:AF084104) (420 aa) fasta scores: E(): 3.3e-27, 27.99% id in 418 aa; hypothetical protein 2496243 2859350 SAR2426 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041778.1 2495011 R 282458 CDS YP_041779.1 49484555 2859351 complement(2496236..2497135) 1 NC_002952.2 Similar to Bacillus firmus hypothetical protein NatA TR:O87564 (EMBL:AF084104) (299 aa) fasta scores: E(): 2.5e-53, 58.3% id in 295 aa, and to Bacillus halodurans ABC transporter BH1166 TR:Q9KDP5 (EMBL:AP001511) (299 aa) fasta scores: E(): 1.8e-52, 55.89% id in 297 aa; ABC transporter ATP-binding protein 2497135 2859351 SAR2427 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041779.1 2496236 R 282458 CDS YP_041780.1 49484556 2859352 complement(2497368..2498015) 1 NC_002952.2 Poor database matches. N-terminus is weakly similar to Streptococcus thermophilus cysteine aminopeptidase PepC TR:Q56116 (EMBL:Z30315) (146 aa) fasta scores: E(): 0.0053, 27.06% id in 133 aa; hypothetical protein 2498015 2859352 SAR2428 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041780.1 2497368 R 282458 CDS YP_041781.1 49484557 2859353 2498007..2498129 1 NC_002952.2 Doubtful CDS; hypothetical protein 2498129 2859353 SAR2428a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041781.1 2498007 D 282458 CDS YP_041782.1 49484558 2859354 2498195..2498326 1 NC_002952.2 Doubtful CDS; hypothetical protein 2498326 2859354 SAR2428b Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041782.1 2498195 D 282458 CDS YP_041783.1 49484559 2859355 2498414..2499022 1 NC_002952.2 Similar to Arabidopsis thaliana DNA-3-methyladenine glycosylase MAG SW:3MG_ARATH (Q39147) (254 aa) fasta scores: E(): 5.8e-08, 29.31% id in 191 aa, and to Bacillus subtilis 3-methyladenine DNA glycosylase YxlJ SW:3MGH_BACSU (P94378) (196 aa) fasta scores: E(): 1.3e-22, 39.68% id in 189 aa; 3-methylpurine glycosylase 2499022 2859355 SAR2429 Staphylococcus aureus subsp. aureus MRSA252 3-methylpurine glycosylase YP_041783.1 2498414 D 282458 CDS YP_041784.1 49484560 2859356 2499358..2500566 1 NC_002952.2 Similar to Escherichia coli sodium/glutamate symport carrier protein GltS SW:GLTS_ECOLI (P19933) (401 aa) fasta scores: E(): 1.9e-48, 39.14% id in 396 aa, and to Pseudomonas aeruginosa sodium/glutamate symporter PA3176 TR:Q9HZ58 (EMBL:AE004741) (404 aa) fasta scores: E(): 3.2e-55, 41.19% id in 403 aa; permease 2500566 2859356 SAR2430 Staphylococcus aureus subsp. aureus MRSA252 permease YP_041784.1 2499358 D 282458 CDS YP_041785.1 49484561 2860674 complement(2500614..2501663) 1 NC_002952.2 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 2501663 fni 2860674 fni Staphylococcus aureus subsp. aureus MRSA252 isopentenyl pyrophosphate isomerase YP_041785.1 2500614 R 282458 CDS YP_041786.1 49484562 2859357 complement(2501694..2502641) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfjQ TR:O31543 (EMBL:Z99108) (319 aa) fasta scores: E(): 1.1e-29, 33.1% id in 296 aa, and to Rhizobium loti divalent cation transport-related protein MLR5559 TR:BAB51987 (EMBL:AP003006) (364 aa) fasta scores: E(): 1e-18, 28.88% id in 322 aa; CorA-like Mg2+ transporter protein 2502641 2859357 SAR2432 Staphylococcus aureus subsp. aureus MRSA252 CorA-like Mg2+ transporter protein YP_041786.1 2501694 R 282458 CDS YP_041787.1 49484563 2859358 2502738..2503229 1 NC_002952.2 Similar to Rhizobium loti hypothetical protein MLR1489 TR:BAB48851 (EMBL:AP002997) (159 aa) fasta scores: E(): 2.3e-09, 25.15% id in 159 aa, and to Pseudomonas aeruginosa hypothetical protein PA5385 TR:Q9HTH9 (EMBL:AE004951) (159 aa) fasta scores: E(): 2.4e-08, 27.56% id in 156 aa; hypothetical protein 2503229 2859358 SAR2433 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041787.1 2502738 D 282458 CDS YP_041788.1 49484564 2859359 2503226..2503645 1 NC_002952.2 Poor database matches. C-terminal region is similar to Bacillus subtilis plasmid pLS32 hypothetical protein TR:O52943 (EMBL:D49467) (98 aa) fasta scores: E(): 0.31, 30% id in 90 aa; hypothetical protein 2503645 2859359 SAR2434 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041788.1 2503226 D 282458 CDS YP_041789.1 49484565 2859360 complement(2503753..2504673) 1 NC_002952.2 Similar to Streptomyces hygroscopicus acetyl-hydrolase Bah SW:BAH_STRHY (Q01109) (299 aa) fasta scores: E(): 4.3e-08, 26.99% id in 226 aa, and to Rhizobium loti esterase MLR1247 TR:BAB48665 (EMBL:AP002997) (317 aa) fasta scores: E(): 6.1e-21, 27.05% id in 292 aa; hypothetical protein 2504673 2859360 SAR2435 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041789.1 2503753 R 282458 CDS YP_041790.1 49484566 2859361 2504881..2505519 1 NC_002952.2 hypothetical protein 2505519 2859361 SAR2436 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041790.1 2504881 D 282458 CDS YP_041791.1 49484567 2859362 complement(2505765..2507702) 1 NC_002952.2 C-terminal region is similar to Escherichia coli multidrug resistance protein B EmrB SW:EMRB_ECOLI (P27304) (512 aa) fasta scores: E(): 1e-33, 29.5% id in 488 aa, and Bacillus subtilis hypothetical transport protein YhcA SW:YHCA_BACSU (P54585) (532 aa) fasta scores: E(): 1e-73, 46.81% id in 502 aa. CDS appears to have an extended N-terminus in comparsion to orthologues; transporter 2507702 2859362 SAR2437 Staphylococcus aureus subsp. aureus MRSA252 transporter YP_041791.1 2505765 R 282458 CDS YP_041792.1 49484568 2859363 complement(2507715..2508362) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YhbJ TR:O31593 (EMBL:Z99108) (221 aa) fasta scores: E(): 7.9e-27, 45.02% id in 211 aa, and to the C-terminal region of Rhizobium etli transport protein RmrA TR:Q9KIH4 (EMBL:AF233286) (396 aa) fasta scores: E(): 9e-08, 30.5% id in 200 aa; hypothetical protein 2508362 2859363 SAR2438 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041792.1 2507715 R 282458 CDS YP_041793.1 49484569 2859364 2508483..2509037 1 NC_002952.2 Similar to Bacillus halodurans transcriptional regulator BH0719 TR:Q9KEY0 (EMBL:AP001509) (188 aa) fasta scores: E(): 1.1e-08, 28.8% id in 184 aa, and to Streptococcus pyogenes transcriptional regulator SPY2177 TR:Q99XJ5 (EMBL:AE006635) (177 aa) fasta scores: E(): 7e-05, 26.4% id in 178 aa; TetR family regulatory protein 2509037 2859364 SAR2439 Staphylococcus aureus subsp. aureus MRSA252 TetR family regulatory protein YP_041793.1 2508483 D 282458 CDS YP_041794.1 49484570 2859520 complement(2509792..2511000) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus teicoplanin resistance associated membrane protein TcaB TR:Q9F4G1 (EMBL:AY008833) (402 aa) fasta scores: E(): 9.9e-140, 99.75% id in 402 aa. Similar to Bacillus subtilis bicyclomycin resistance protein YdgK TR:P96709 (EMBL:AB001488) (402 aa) fasta scores: E(): 8.8e-42, 38.17% id in 372 aa; teicoplanin resistance associated membrane protein 2511000 tcaB 2859520 tcaB Staphylococcus aureus subsp. aureus MRSA252 teicoplanin resistance associated membrane protein YP_041794.1 2509792 R 282458 CDS YP_041795.1 49484571 2859519 complement(2511268..2512650) 1 NC_002952.2 No significant database matches. Previously sequenced as Staphylococcus aureus teicoplanin resistance associated hypothetical transmembrane protein TcaA TR:Q9F4G2 (EMBL:AY008833) (460 aa) fasta scores: E(): 5.2e-158, 98.69% id in 460 aa; teicoplanin resistance associated membrane protein 2512650 tcaA 2859519 tcaA Staphylococcus aureus subsp. aureus MRSA252 teicoplanin resistance associated membrane protein YP_041795.1 2511268 R 282458 CDS YP_041796.1 49484572 2859521 complement(2512890..2513345) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus teicoplanin resistance associated transcription regulator TcaR TR:Q9F4G3 (EMBL:AY008833) (151 aa) fasta scores: E(): 4.4e-47, 100% id in 151 aa. Similar to Bacillus subtilis YdgG TR:P96705 (EMBL:AB001488) (152 aa) fasta scores: E(): 0.00029, 25% id in 136 aa; MarR family regulatory protein 2513345 tcaR 2859521 tcaR Staphylococcus aureus subsp. aureus MRSA252 MarR family regulatory protein YP_041796.1 2512890 R 282458 CDS YP_041797.1 49484573 2859366 2513540..2514508 1 NC_002952.2 Similar to Staphylococcus epidermidis membrane protein EpiH TR:O07859 (EMBL:U77778) (330 aa) fasta scores: E(): 5.5e-18, 30.12% id in 312 aa, and to Staphylococcus gallinarum membrane protein GdmH TR:O07474 (EMBL:U61158) (330 aa) fasta scores: E(): 1.3e-16, 30.89% id in 314 aa; hypothetical protein 2514508 2859366 SAR2444 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041797.1 2513540 D 282458 CDS YP_041798.1 49484574 2859367 complement(2514738..2515403) 1 NC_002952.2 Similar to Lactococcus lactis ABC transporter ATP-binding protein YxeB TR:Q9CDG4 (EMBL:AE006454) (223 aa) fasta scores: E(): 2.5e-30, 46.6% id in 221 aa, and to Streptococcus pyogenes ABC transporter SPY0773 TR:Q9A0H6 (EMBL:AE006528) (222 aa) fasta scores: E(): 1.3e-26, 42% id in 219 aa; ABC transporter ATP-binding protein 2515403 2859367 SAR2445 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041798.1 2514738 R 282458 CDS YP_041799.1 49484575 2859368 complement(2515403..2516458) 1 NC_002952.2 Similar to Deinococcus radiodurans hypothetical protein DRA0279 TR:Q9RYN1 (EMBL:AE001863) (353 aa) fasta scores: E(): 2.3e-22, 29.94% id in 354 aa, and to Lactococcus lactis ABC transporter permease YgfB TR:Q9CHR2 (EMBL:AE006299) (357 aa) fasta scores: E(): 6.3e-22, 29.36% id in 361 aa; permease 2516458 2859368 SAR2446 Staphylococcus aureus subsp. aureus MRSA252 permease YP_041799.1 2515403 R 282458 CDS YP_041800.1 49484576 2859369 2516594..2517268 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Similar to Mycobacterium tuberculosis sensory transduction protein RegX3 SW:RGX3_MYCTU (Q11156) (227 aa) fasta scores: E(): 2.3e-28, 40.96% id in 227 aa, and to Mycobacterium bovis sensory transduction protein RegX3 SW:RGX3_MYCBO (O07130) (227 aa) fasta scores: E(): 4.9e-28, 40.52% id in 227 aa; response regulator protein 2517268 2859369 SAR2447 Staphylococcus aureus subsp. aureus MRSA252 response regulator protein YP_041800.1 2516594 D 282458 CDS YP_041801.1 49484577 2859370 2517261..2518634 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Similar to Escherichia coli copper-responsive sensor kinase CusS SW:CUSS_ECOLI (P77485) (480 aa) fasta scores: E(): 7.4e-17, 27.44% id in 481 aa, and to Bacillus subtilis hypothetical protein YvqB TR:O32193 (EMBL:Z99120) (451 aa) fasta scores: E(): 3.2e-16, 25.32% id in 458 aa; sensor kinase 2518634 2859370 SAR2448 Staphylococcus aureus subsp. aureus MRSA252 sensor kinase YP_041801.1 2517261 D 282458 CDS YP_041802.1 49484578 2859371 2518797..2519240 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YfcC TR:Q9CI31 (EMBL:AE006287) (152 aa) fasta scores: E(): 0.19, 24.32% id in 148 aa. C-terminus is similar to the C-terminal region of Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR SW:ALGR_PSEAE (P26275) (248 aa) fasta scores: E(): 0.16, 29.52% id in 105 aa; hypothetical protein 2519240 2859371 SAR2449 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041802.1 2518797 D 282458 CDS YP_041803.1 49484579 2861010 2519237..2519692 1 NC_002952.2 Poor database matches. Weak similarity to Ochromonas danica hypothetical protein Orf154 TR:Q9G294 (EMBL:AF287134) (154 aa) fasta scores: E(): 0.38, 25.85% id in 147 aa; hypothetical protein 2519692 2861010 SAR2450 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041803.1 2519237 D 282458 CDS YP_041804.1 49484580 2858975 complement(2519869..2520432) 1 NC_002952.2 Similar to Streptococcus pyogenes transcriptional regulator SPY2177 TR:Q99XJ5 (EMBL:AE006635) (177 aa) fasta scores: E(): 1.8e-11, 29.88% id in 174 aa, and to Bacillus halodurans transcriptional regulator BH0719 TR:Q9KEY0 (EMBL:AP001509) (188 aa) fasta scores: E(): 5.4e-09, 26.66% id in 180 aa; hypothetical protein 2520432 2858975 SAR2451 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041804.1 2519869 R 282458 CDS YP_041805.1 49484581 2858976 2520566..2521294 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YfiL TR:P94440 (EMBL:D78508) (311 aa) fasta scores: E(): 4.7e-24, 41.07% id in 224 aa. Similar to an internal region of Rhizobium sp nodulation ATP-binding protein I NodI SW:NODI_RHISN (P55476) (343 aa) fasta scores: E(): 1.1e-22, 38.59% id in 228 aa; ABC transporter ATP-binding protein 2521294 2858976 SAR2452 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041805.1 2520566 D 282458 CDS YP_041806.1 49484582 2858977 2521291..2522373 1 NC_002952.2 Similar to Lactococcus lactis ABC transporter permease YcfC TR:Q9CIV1 (EMBL:AE006262) (380 aa) fasta scores: E(): 1.7e-30, 37.46% id in 379 aa, and to Archaeoglobus fulgidus ABC transporter ATP-binding protein AF1005 TR:O29257 (EMBL:AE001034) (366 aa) fasta scores: E(): 1.4e-17, 22.06% id in 358 aa; hypothetical protein 2522373 2858977 SAR2453 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041806.1 2521291 D 282458 CDS YP_041807.2 161761281 2861307 complement(2522500..2523978) 1 NC_002952.2 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2523978 mqo1 2861307 mqo1 Staphylococcus aureus subsp. aureus MRSA252 malate:quinone oxidoreductase YP_041807.2 2522500 R 282458 CDS YP_041808.1 49484584 2859807 complement(2524359..2525957) 1 NC_002952.2 Similar to Escherichia coli L-lactate permease LldP SW:LLDP_ECOLI (P33231) (551 aa) fasta scores: E(): 6.2e-49, 45.1% id in 541 aa, and to Bacillus subtilis L-lactate permease LctP TR:O31470 (EMBL:Z99105) (541 aa) fasta scores: E(): 1.4e-95, 50.73% id in 542 aa. Similar to SAR0113, 65.977% identity (66.352% ungapped) in 532 aa overlap; L-lactate permease 2 2525957 lldP2 2859807 lldP2 Staphylococcus aureus subsp. aureus MRSA252 L-lactate permease 2 YP_041808.1 2524359 R 282458 CDS YP_041809.1 49484585 2858978 2526274..2527947 1 NC_002952.2 No significant database matches to the full length CDS. Internal region of the CDS is similar to an internal region of Staphylococcus epidermidis CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase TagF TR:Q9RPD1 (EMBL:AF162863) (721 aa) fasta scores: E(): 0.0032, 23.76% id in 324 aa, and to Lactococcus lactis teichoic acid biosynthesis protein B TagB TR:Q9CH14 (EMBL:AE006327) (371 aa) fasta scores: E(): 0.041, 22.22% id in 234 aa; hypothetical protein 2527947 2858978 SAR2456 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041809.1 2526274 D 282458 CDS YP_041810.1 49484586 2858979 complement(2528101..2528730) 1 NC_002952.2 No significant database matches. Contains hydrophobic region, residues 18 to 107; hypothetical protein 2528730 2858979 SAR2457 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041810.1 2528101 R 282458 CDS YP_041811.1 49484587 2858980 complement(2529046..2529561) 1 NC_002952.2 Similar to Bacillus subtilis protease synthase and sporulation negative regulatory protein Pai 1 PaiA SW:PAIA_BACSU (P21340) (171 aa) fasta scores: E(): 1.5e-21, 41.31% id in 167 aa, and to Lactobacillus delbrueckii hypothetical protein SW:YPIP_LACDL (P46543) (173 aa) fasta scores: E(): 5.7e-21, 38.95% id in 172 aa; acetyltransferase (GNAT) family protein 2529561 2858980 SAR2458 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_041811.1 2529046 R 282458 CDS YP_041812.1 49484588 2858981 2529751..2530755 1 NC_002952.2 Similar to Homo sapiens quinone oxidoreductase CRYZ SW:QOR_HUMAN (Q08257) (329 aa) fasta scores: E(): 1.6e-10, 28.23% id in 301 aa, and to Bacillus subtilis hypothetical protein YhfP TR:O07615 (EMBL:Y14084) (330 aa) fasta scores: E(): 4.2e-54, 47.41% id in 329 aa; zinc-binding dehydrogenase 2530755 2858981 SAR2459 Staphylococcus aureus subsp. aureus MRSA252 zinc-binding dehydrogenase YP_041812.1 2529751 D 282458 CDS YP_041813.1 49484589 2858982 complement(2531321..2531722) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YfiL TR:Q9CHW9 (EMBL:AE006293) (154 aa) fasta scores: E(): 0.0048, 29.46% id in 112 aa, and to Streptococcus pyogenes ribosomal-protein-alanine acetyltransferase SPY1873 TR:Q99Y45 (EMBL:AE006612) (141 aa) fasta scores: E(): 0.02, 30.43% id in 115 aa; acetyltransferase (GNAT) family protein 2531722 2858982 SAR2460 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_041813.1 2531321 R 282458 CDS YP_041814.1 49484590 2858983 complement(2531758..2532792) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YcgT TR:O31475 (EMBL:Z99105) (336 aa) fasta scores: E(): 1.4e-37, 36.58% id in 328 aa, and to Bacillus halodurans thioredoxin reductase BH3408 TR:Q9K7F3 (EMBL:AP001518) (330 aa) fasta scores: E(): 1.4e-34, 34.45% id in 328 aa; pyridine nucleotide-disulfide oxidoreductase 2532792 2858983 SAR2461 Staphylococcus aureus subsp. aureus MRSA252 pyridine nucleotide-disulfide oxidoreductase YP_041814.1 2531758 R 282458 CDS YP_041815.1 49484591 2858984 complement(2533019..2533450) 1 NC_002952.2 Poor database matches. Weak similarity to Rhizobium loti hypothetical protein MLR0532 TR:BAB48098 (EMBL:AP002995) (160 aa) fasta scores: E(): 1.1, 25.33% id in 150 aa; hypothetical protein 2533450 2858984 SAR2462 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041815.1 2533019 R 282458 CDS YP_041816.1 49484592 2858985 complement(2533656..2534933) 1 NC_002952.2 No significant database matches to the full length CDS. N-terminus is weakly similar to the N-terminal region of Lactococcus lactis phage infection protein Pip SW:PIP_LACLA (P49022) (901 aa) fasta scores: E(): 0.00046, 27.12% id in 317 aa; hypothetical protein 2534933 2858985 SAR2463 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041816.1 2533656 R 282458 CDS YP_041817.1 49484593 2858986 2535094..2535717 1 NC_002952.2 Similar to Lactococcus lactis transcriptional regulator YxcB TR:Q9CDI1 (EMBL:AE006453) (204 aa) fasta scores: E(): 3e-10, 26.86% id in 201 aa, and to Bacillus halodurans transcriptional regulator BH0719 TR:Q9KEY0 (EMBL:AP001509) (188 aa) fasta scores: E(): 1.5e-08, 29.67% id in 182 aa; TetR family regulatory protein 2535717 2858986 SAR2464 Staphylococcus aureus subsp. aureus MRSA252 TetR family regulatory protein YP_041817.1 2535094 D 282458 CDS YP_041818.1 49484594 2858987 2535763..2536707 1 NC_002952.2 Similar to Streptococcus pyogenes divalent cation transport protein SPY1827 TR:Q99Y83 (EMBL:AE006609) (314 aa) fasta scores: E(): 2.3e-31, 37.28% id in 295 aa, and to Lactococcus lactis cationic transporter ypbB TR:Q9CFJ3 (EMBL:AE006378) (301 aa) fasta scores: E(): 5e-32, 36.64% id in 292 aa; CorA-like Mg2+ transporter protein 2536707 2858987 SAR2465 Staphylococcus aureus subsp. aureus MRSA252 CorA-like Mg2+ transporter protein YP_041818.1 2535763 D 282458 CDS YP_041819.1 49484595 2859126 complement(2536793..2538235) 1 NC_002952.2 Similar to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SW:PTSB_STAXY (P51184) (480 aa) fasta scores: E(): 5.9e-145, 82.21% id in 478 aa, and to Vibrio cholerae PTS system, sucrose-specific IIBC component VCA0653 TR:Q9KLT8 (EMBL:AE004395) (479 aa) fasta scores: E(): 8.3e-104, 59.16% id in 480 aa; PTS system, sucrose-specific IIBC component 2538235 scrA 2859126 scrA Staphylococcus aureus subsp. aureus MRSA252 PTS system, sucrose-specific IIBC component YP_041819.1 2536793 R 282458 CDS YP_041820.1 49484596 2858988 2538418..2538801 1 NC_002952.2 Poor database matches. Similar to Streptococcus pyogenes hypothetical protein SPY0771 TR:Q9A0H8 (EMBL:AE006528) (128 aa) fasta scores: E(): 1.8e-09, 35.59% id in 118 aa; hypothetical protein 2538801 2858988 SAR2467 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041820.1 2538418 D 282458 CDS YP_041821.1 49484597 2858989 2540289..2542394 1 NC_002952.2 No significant database matches to the full length CDS. N-terminal region is weakly similar to Streptococcus mutans msm operon regulatory protein MsmR SW:MSMR_STRMU (Q00753) (278 aa) fasta scores: E(): 4.3e-06, 25.71% id in 245 aa; AraC family transcription regulator 2542394 2858989 SAR2468 Staphylococcus aureus subsp. aureus MRSA252 AraC family transcription regulator YP_041821.1 2540289 D 282458 CDS YP_041822.1 49484598 2858990 2542465..2542887 1 NC_002952.2 Similar to Bacillus subtilis general stress protein 26 YdaG SW:GS26_BACSU (P80238) (140 aa) fasta scores: E(): 3.1e-16, 38.57% id in 140 aa; hypothetical protein 2542887 2858990 SAR2469 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041822.1 2542465 D 282458 CDS YP_041823.1 49484599 2858991 2543165..2543521 1 NC_002952.2 Poor database matches. Weakly similar to Fowlpox virus hypothetical protein FPV145 TR:Q9J585 (EMBL:AF198100) (103 aa) fasta scores: E(): 1.2, 27.27% id in 99 aa; hypothetical protein 2543521 2858991 SAR2470 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041823.1 2543165 D 282458 CDS YP_041824.1 49484600 2858992 complement(2543734..2545380) 1 NC_002952.2 Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 7.9e-199, 99.453% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 3.2e-99, 52.115% id in 520 aa; transposase 2545380 2858992 SAR2471 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_041824.1 2543734 R 282458 CDS YP_041825.1 49484601 2859932 complement(2545682..2546959) 1 NC_002952.2 Similar to Bacillus stearothermophilus proton/sodium-glutamate symport protein GltT SW:GLTT_BACST (P24943) (421 aa) fasta scores: E(): 1.7e-88, 55.23% id in 420 aa, and to Bacillus caldotenax proton/sodium-glutamate symport protein GltT SW:GLTT_BACCA (P24944) (421 aa) fasta scores: E(): 3.3e-88, 55.63% id in 417 aa; proton/sodium-glutamate symport protein 2546959 gltT 2859932 gltT Staphylococcus aureus subsp. aureus MRSA252 proton/sodium-glutamate symport protein YP_041825.1 2545682 R 282458 CDS YP_041826.1 49484602 2858993 complement(2547141..2547506) 1 NC_002952.2 Poor database matches. Similar to the N-terminal region of Bacillus halodurans D-alanyl-D-alanine carboxypeptidase BH1810 TR:Q9KBW4 (EMBL:AP001513) (290 aa) fasta scores: E(): 1.5, 28.88% id in 90 aa; hypothetical protein 2547506 2858993 SAR2473 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041826.1 2547141 R 282458 CDS YP_041827.1 49484603 2858994 2547903..2548349 1 NC_002952.2 N-terminus is similar to the N-terminal regions of Lactococcus lactis transcriptional regulator RmaJ TR:Q9CHX7 (EMBL:AE006292) (143 aa) fasta scores: E(): 4e-18, 55.35% id in 112 aa, and Bacillus subtilis hypothetical protein YkmA TR:O34777 (EMBL:AJ002571) (147 aa) fasta scores: E(): 3.2e-13, 45.71% id in 105 aa; MarR family regulatory protein 2548349 2858994 SAR2474 Staphylococcus aureus subsp. aureus MRSA252 MarR family regulatory protein YP_041827.1 2547903 D 282458 CDS YP_041828.1 49484604 2858995 2548573..2548995 1 NC_002952.2 Similar to Clostridium acetobutylicum 18 kDa heat shock protein Hsp18 SW:HS18_CLOAB (Q03928) (151 aa) fasta scores: E(): 1e-06, 31.74% id in 126 aa, and to Streptococcus thermophilus second small heat shock protein Hsp2 TR:O52192 (EMBL:AF027167) (142 aa) fasta scores: E(): 5.4e-13, 40.84% id in 142 aa; small heat shock protein 2548995 2858995 SAR2475 Staphylococcus aureus subsp. aureus MRSA252 small heat shock protein YP_041828.1 2548573 D 282458 CDS YP_041829.1 49484605 2859724 complement(2549103..2550272) 1 NC_002952.2 Similar to Staphylococcus carnosus nitrate transporter NarT TR:O33854 (EMBL:U40014) (388 aa) fasta scores: E(): 6.1e-106, 74.54% id in 381 aa, and to Bacillus subtilis nitrite extrusion protein NarK SW:NARK_BACSU (P46907) (395 aa) fasta scores: E(): 3.8e-72, 53.47% id in 374 aa; nitrite transport protein 2550272 narT 2859724 narT Staphylococcus aureus subsp. aureus MRSA252 nitrite transport protein YP_041829.1 2549103 R 282458 CDS YP_041830.1 49484606 2859952 2550781..2551695 1 NC_002952.2 Poor database matches. Similar to Bacillus subtilis hypothetical protein YjfC TR:O34458 (EMBL:AF015825) (309 aa) fasta scores: E(): 1e-22, 30.2% id in 298 aa; hypothetical protein 2551695 2859952 SAR2477 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041830.1 2550781 D 282458 CDS YP_041831.1 49484607 2859954 complement(2552668..2553321) 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Similar to Vibrio vulnificus transcriptional regulator TR:Q9AEP5 (EMBL:AY029275) (212 aa) fasta scores: E(): 4.1e-26, 42.13% id in 216 aa. C-terminal region is similar to Staphylococcus carnosus response regulator-like protein TR:Q9ZB65 (EMBL:U40158) (185 aa) fasta scores: E(): 1.1e-58, 85.4% id in 185 aa; response regulator 2553321 2859954 SAR2480 Staphylococcus aureus subsp. aureus MRSA252 response regulator YP_041831.1 2552668 R 282458 CDS YP_041832.1 49484608 2859955 complement(2553344..2554378) 1 NC_002952.2 C-terminus is similar to the C-terminal regions of Bacillus subtilis sensor protein two-component sensor histidine kinase DegS SW:DEGS_BACSU (P13799) (385 aa) fasta scores: E(): 1.7e-16, 29.56% id in 274 aa, and Bacillus halodurans two-component sensor histidine kinase BH3629 TR:Q9K6U6 (EMBL:AP001519) (377 aa) fasta scores: E(): 1.1e-18, 30.11% id in 269 aa; histidine kinase 2554378 2859955 SAR2481 Staphylococcus aureus subsp. aureus MRSA252 histidine kinase YP_041832.1 2553344 R 282458 CDS YP_041833.1 49484609 2859956 complement(2554402..2554854) 1 NC_002952.2 Poor database matches. Similar to an internal region of Streptomyces coelicolor hypothetical protein 2SCG2.24c TR:Q9EX29 (EMBL:AL445963) (634 aa) fasta scores: E(): 1.1, 23.3% id in 133 aa; hypothetical protein 2554854 2859956 SAR2482 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041833.1 2554402 R 282458 CDS YP_041834.1 49484610 2861335 complement(2554874..2555551) 1 NC_002952.2 Similar to Bacillus subtilis nitrate reductase gamma chain NarI SW:NARI_BACSU (P42177) (223 aa) fasta scores: E(): 1.3e-41, 49.09% id in 222 aa, and to Staphylococcus carnosus nitrate reductase gamma chain NarI TR:Q9ZIF5 (EMBL:AF029224) (227 aa) fasta scores: E(): 1.1e-64, 70.53% id in 224 aa; nitrate reductase gamma chain 2555551 narI 2861335 narI Staphylococcus aureus subsp. aureus MRSA252 nitrate reductase gamma chain YP_041834.1 2554874 R 282458 CDS YP_041835.1 49484611 2859722 complement(2555544..2556119) 1 NC_002952.2 Similar to Escherichia coli respiratory nitrate reductase 2 delta chain NarW SW:NARW_ECOLI (P19317) (231 aa) fasta scores: E(): 0.00098, 24.71% id in 174 aa, and to Staphylococcus carnosus nitrate reductase delta chain NarJ TR:Q9ZIF6 (EMBL:AF029224) (191 aa) fasta scores: E(): 7.8e-52, 68.06% id in 191 aa; respiratory nitrate reductase delta chain 2556119 narJ 2859722 narJ Staphylococcus aureus subsp. aureus MRSA252 respiratory nitrate reductase delta chain YP_041835.1 2555544 R 282458 CDS YP_041836.1 49484612 2861334 complement(2556112..2557671) 1 NC_002952.2 Similar to Bacillus subtilis nitrate reductase beta chain NarH SW:NARH_BACSU (P42176) (487 aa) fasta scores: E(): 5.3e-142, 66.94% id in 484 aa, and to Staphylococcus carnosus nitrate reductase beta chain NarH TR:Q9ZIF7 (EMBL:AF029224) (525 aa) fasta scores: E(): 1.5e-187, 83.61% id in 525 aa; nitrate reductase subunit beta 2557671 narH 2861334 narH Staphylococcus aureus subsp. aureus MRSA252 nitrate reductase subunit beta YP_041836.1 2556112 R 282458 CDS YP_041837.1 49484613 2861333 complement(2557661..2561350) 1 NC_002952.2 Similar to Bacillus subtilis nitrate reductase alpha chain NarG SW:NARG_BACSU (P42175) (1228 aa) fasta scores: E(): 0, 59.21% id in 1226 aa, and to Staphylococcus carnosus nitrate reductase alpha chainNarG TR:Q9ZIF8 (EMBL:AF029224) (1224 aa) fasta scores: E(): 0, 80.55% id in 1229 aa; nitrate reductase subunit alpha 2561350 narG 2861333 narG Staphylococcus aureus subsp. aureus MRSA252 nitrate reductase subunit alpha YP_041837.1 2557661 R 282458 CDS YP_041838.1 49484614 2859957 complement(2561657..2562634) 1 NC_002952.2 N-terminal region is similar to Bacillus megaterium uroporphyrin-III C-methyltransferase CobA SW:SUMT_BACME (P29928) (238 aa) fasta scores: E(): 2.8e-31, 43.69% id in 238 aa. Full length CDS is similar to Staphylococcus carnosus hypothetical protein SirB TR:Q9X2N1 (EMBL:AF029224) (317 aa) fasta scores: E(): 2.6e-57, 52.05% id in 317 aa; tetrapyrrole (corrin/porphyrin) methylase 2562634 2859957 SAR2487 Staphylococcus aureus subsp. aureus MRSA252 tetrapyrrole (corrin/porphyrin) methylase YP_041838.1 2561657 R 282458 CDS YP_041839.1 49484615 2859163 complement(2562625..2562939) 1 NC_002952.2 Similar to Bacillus subtilis assimilatory nitrite reductase [NAD(P)H] small subunit NasE SW:NASE_BACSU (P42436) (106 aa) fasta scores: E(): 1.3e-17, 50.51% id in 97 aa, and to Staphylococcus carnosus assimilatory nitrite reductase small subunit NirD TR:Q9X2N0 (EMBL:AF029224) (104 aa) fasta scores: E(): 1.3e-29, 69.23% id in 104 aa; assimilatory nitrite reductase small subunit 2562939 nasE 2859163 nasE Staphylococcus aureus subsp. aureus MRSA252 assimilatory nitrite reductase small subunit YP_041839.1 2562625 R 282458 CDS YP_041840.1 49484616 2859162 complement(2562943..2565348) 1 NC_002952.2 Similar to Bacillus subtilis nitrite reductase [NAD(P)H] large subunit NasD SW:NASD_BACSU (P42435) (805 aa) fasta scores: E(): 2.6e-168, 53.18% id in 801 aa, and to Staphylococcus carnosus nitrite reductase [NAD(P)H] large subunit NirB TR:Q9X2M9 (EMBL:AF029224) (801 aa) fasta scores: E(): 0, 77.77% id in 801 aa; nitrite reductase large subunit 2565348 nasD 2859162 nasD Staphylococcus aureus subsp. aureus MRSA252 nitrite reductase large subunit YP_041840.1 2562943 R 282458 CDS YP_041841.1 49484617 2859958 complement(2565394..2566146) 1 NC_002952.2 Similar to Staphylococcus carnosus hypothetical protein NirR TR:Q9X2M7 (EMBL:AF029224) (240 aa) fasta scores: E(): 3e-26, 35.16% id in 236 aa, and to Bacillus subtilis hypothetical protein YlnE TR:O34632 (EMBL:AJ000974) (261 aa) fasta scores: E(): 4.9e-09, 22.67% id in 247 aa; hypothetical protein 2566146 2859958 SAR2490 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041841.1 2565394 R 282458 CDS YP_041842.1 49484618 2859959 complement(2566374..2566910) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YtmI TR:O34350 (EMBL:AF008220) (178 aa) fasta scores: E(): 7.9e-40, 57.95% id in 176 aa, and to Bacillus subtilis hypothetical protein YxeL SW:YXEL_BACSU (P54951) (165 aa) fasta scores: E(): 1.7e-24, 45.86% id in 157 aa; acetyltransferase (GNAT) family protein 2566910 2859959 SAR2491 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_041842.1 2566374 R 282458 CDS YP_041843.1 49484619 2859960 complement(2567378..2568202) 1 NC_002952.2 Similar to Escherichia coli potential nitrite transporter NirC SW:NIRC_ECOLI (P11097) (268 aa) fasta scores: E(): 6.3e-12, 30.57% id in 242 aa, and to Staphylococcus carnosus potential nitrite transporter NirC TR:Q9X2M6 (EMBL:AF029224) (276 aa) fasta scores: E(): 5.3e-63, 63.63% id in 275 aa; nitrite transporter 2568202 2859960 SAR2493 Staphylococcus aureus subsp. aureus MRSA252 nitrite transporter YP_041843.1 2567378 R 282458 CDS YP_041844.1 49484620 2859961 complement(2568405..2568587) 1 NC_002952.2 hypothetical protein 2568587 2859961 SAR2494 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041844.1 2568405 R 282458 CDS YP_041845.1 49484621 2859962 complement(2568673..2569140) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0695 TR:Q9KF04 (EMBL:AP001509) (169 aa) fasta scores: E(): 7e-09, 28.22% id in 163 aa, and to Caulobacter crescentus hypothetical protein CC3077 TR:Q9A3X4 (EMBL:AE005971) (158 aa) fasta scores: E(): 1.9e-05, 26.49% id in 151 aa; hypothetical protein 2569140 2859962 SAR2495 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041845.1 2568673 R 282458 CDS YP_041846.1 49484622 2859963 complement(2569326..2570873) 1 NC_002952.2 Similar to Streptococcus pyogenes zinc-binding protein AdcA precursor SPY0714 TR:Q9A0L9 (EMBL:AE006523) (515 aa) fasta scores: E(): 1.9e-53, 37.02% id in 524 aa. N-terminal region is similar to Bacillus subtilis hypothetical protein YcdH TR:O34966 (EMBL:AB000617) (319 aa) fasta scores: E(): 1.7e-15, 33.84% id in 325 aa; solute binding lipoprotein 2570873 2859963 SAR2496 Staphylococcus aureus subsp. aureus MRSA252 solute binding lipoprotein YP_041846.1 2569326 R 282458 CDS YP_041847.1 49484623 2859964 complement(2571166..2571432) 1 NC_002952.2 Similar to Escherichia coli hypothetical protein YoeB SW:YOEB_ECOLI (P56605) (84 aa) fasta scores: E(): 6.8e-14, 52.94% id in 85 aa, and to Streptomyces coelicolor hypothetical protein SCBAC17D6.03 TR:Q9Z4V8 (EMBL:Y17736) (84 aa) fasta scores: E(): 1.1e-11, 47.05% id in 85 aa; hypothetical protein 2571432 2859964 SAR2497 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041847.1 2571166 R 282458 CDS YP_041848.1 49484624 2859965 complement(2571432..2571683) 1 NC_002952.2 Similar to Escherichia coli hypothetical protein YefM SW:YEFM_ECOLI (P46147) (83 aa) fasta scores: E(): 3.7e-07, 44.15% id in 77 aa, and to Streptomyces coelicolor hypothetical protein SCBAC17D6.02 SW:YU1E_STRCO (Q9Z4V7) (87 aa) fasta scores: E(): 1.4e-05, 42.66% id in 75 aa; hypothetical protein 2571683 2859965 SAR2498 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041848.1 2571432 R 282458 CDS YP_041849.1 49484625 2859966 complement(2571954..2572553) 1 NC_002952.2 Similar to Caulobacter crescentus hypothetical protein CC0375 TR:Q9AB57 (EMBL:AE005710) (204 aa) fasta scores: E(): 0.00026, 28.27% id in 191 aa. C-terminus is similar to the C-terminal region of Bacillus subtilis hypothetical protein YvgV TR:O32218 (EMBL:Z99121) (222 aa) fasta scores: E(): 7e-14, 36.41% id in 173 aa; lipoprotein 2572553 2859966 SAR2499 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_041849.1 2571954 R 282458 CDS YP_041850.1 49484626 2859967 complement(2572572..2572934) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YddJ TR:P96647 (EMBL:AB001488) (126 aa) fasta scores: E(): 0.12, 29.34% id in 92 aa; lipoprotein 2572934 2859967 SAR2500 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_041850.1 2572572 R 282458 CDS YP_041851.1 49484627 2860668 2573189..2574439 1 NC_002952.2 Similar to Staphylococcus aureus factor essential for expression of methicillin resistance FemA SW:FEMA_STAAU (P14304) (433 aa) fasta scores: E(): 7.3e-63, 43.82% id in 413 aa. Previously sequenced as Staphylococcus aureus FemA-like protein FmhA TR:Q9X4D6 (EMBL:AF106849) (416 aa) fasta scores: E(): 1.1e-152, 98.31% id in 416 aa. Similar to SAR1224, 60.934% identity (60.934% ungapped) in 407 aa overlap; FemAB family protein 2574439 fmhA 2860668 fmhA Staphylococcus aureus subsp. aureus MRSA252 FemAB family protein YP_041851.1 2573189 D 282458 CDS YP_041852.1 49484628 2859968 complement(2574532..2575263) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YckI TR:Q9F4F9 (EMBL:AY009114) (247 aa) fasta scores: E(): 1.8e-44, 58.43% id in 243 aa, and to Bacillus halodurans amino acid ABC transporter (ATP-binding protein) BH0172 TR:Q9KGD1 (EMBL:AP001507) (247 aa) fasta scores: E(): 2.7e-44, 58.6% id in 244 aa. Similar to SAR1948, 54.622% identity (55.319% ungapped) in 238 aa overlap; ABC transporter ATP-binding protein 2575263 2859968 SAR2502 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041852.1 2574532 R 282458 CDS YP_041853.1 49484629 2859969 complement(2575260..2575979) 1 NC_002952.2 Similar to Lactobacillus fermentum integral membrane protein homologue TR:O06528 (EMBL:U97348) (233 aa) fasta scores: E(): 2.3e-31, 45.74% id in 223 aa, and to Lactobacillus reuteri transmembrane protein TR:Q9FCU7 (EMBL:AJ293860) (233 aa) fasta scores: E(): 3.1e-31, 46.18% id in 223 aa; transport system membrane protein 2575979 2859969 SAR2503 Staphylococcus aureus subsp. aureus MRSA252 transport system membrane protein YP_041853.1 2575260 R 282458 CDS YP_041854.1 49484630 2859970 complement(2575960..2576739) 1 NC_002952.2 Similar to Escherichia coli cystine-binding periplasmic protein precursor FliY SW:FLIY_ECOLI (P39174) (266 aa) fasta scores: E(): 1e-22, 37.22% id in 231 aa, and to Haemophilus influenzae probable amino-acid ABC transporter binding protein HI1080 SW:YA80_HAEIN (P45024) (257 aa) fasta scores: E(): 6.6e-39, 45.73% id in 258 aa; extracellular solute-binding lipoprotein 2576739 2859970 SAR2504 Staphylococcus aureus subsp. aureus MRSA252 extracellular solute-binding lipoprotein YP_041854.1 2575960 R 282458 CDS YP_041855.1 49484631 2859971 complement(2576860..2578299) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YcnB TR:P94422 (EMBL:D50453) (472 aa) fasta scores: E(): 2e-68, 41.7% id in 470 aa, and to Bacillus subtilis lincomycin-resistance protein LmrB TR:O35018 (EMBL:AB000617) (479 aa) fasta scores: E(): 1.2e-62, 37.44% id in 478 aa; transporter 2578299 2859971 SAR2505 Staphylococcus aureus subsp. aureus MRSA252 transporter YP_041855.1 2576860 R 282458 CDS YP_041856.1 49484632 2859972 complement(2578730..2579416) 1 NC_002952.2 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 2579416 gpmA 2859972 gpmA Staphylococcus aureus subsp. aureus MRSA252 phosphoglyceromutase YP_041856.1 2578730 R 282458 CDS YP_041857.1 49484633 2859973 complement(2579743..2580609) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdbO TR:P96610 (EMBL:AB001488) (290 aa) fasta scores: E(): 2.8e-42, 42.9% id in 289 aa, and to the N-terminal region of Streptococcus pyogenes cation efflux system protein SPY1272 TR:Q99ZD9 (EMBL:AE006566) (411 aa) fasta scores: E(): 9.5e-40, 40.92% id in 281 aa; cation efflux family protein 2580609 2859973 SAR2507 Staphylococcus aureus subsp. aureus MRSA252 cation efflux family protein YP_041857.1 2579743 R 282458 CDS YP_041858.1 49484634 2859124 2581308..2582621 1 NC_002952.2 Similar to Staphylococcus aureus IgG-binding protein Sbi TR:O52187 (EMBL:AF027155) (436 aa) fasta scores: E(): 2.2e-121, 93.13% id in 437 aa. N-terminus is similar to the N-terminal region of Staphylococcus aureus immunoglobulin G binding protein A precursor Spa SW:SPA1_STAAU (P02976) (524 aa) fasta scores: E(): 1.4e-07, 28.77% id in 351 aa; IgG-binding protein 2582621 sbi 2859124 sbi Staphylococcus aureus subsp. aureus MRSA252 IgG-binding protein YP_041858.1 2581308 D 282458 CDS YP_041859.1 49484635 2859641 2583157..2584086 1 NC_002952.2 Highly similar to Staphylococcus aureus gamma-hemolysin component A precursor HlgA SW:HLGA_STAAU (P31714) (309 aa) fasta scores: E(): 3.1e-115, 99.35% id in 309 aa. Similar to Staphylococcus aureus leukocidin S subunit precursor LukS SW:LUKS_STAAU (P31716) (315 aa) fasta scores: E(): 1.4e-76, 68.26% id in 312 aa. Similar to SAR2510, 68.910% identity (70.724% ungapped) in 312 aa overlap; gamma-hemolysin component A precursor 2584086 hlgA 2859641 hlgA Staphylococcus aureus subsp. aureus MRSA252 gamma-hemolysin component A precursor YP_041859.1 2583157 D 282458 CDS YP_041860.1 49484636 2859643 2584636..2585583 1 NC_002952.2 Highly similar to Staphylococcus aureus leukocidin S subunit precursor LukS SW:LUKS_STAAU (P31716) (315 aa) fasta scores: E(): 8.6e-118, 97.77% id in 315 aa. Similar to Staphylococcus aureus gamma-hemolysin component A precursor HlgA SW:HLGA_STAAU (P31714) (309 aa) fasta scores: E(): 1.3e-77, 68.59% id in 312 aa. Similar to SAR2509, 68.910% identity (70.724% ungapped) in 312 aa overlap; gamma-hemolysin component C precursor 2585583 hlgC 2859643 hlgC Staphylococcus aureus subsp. aureus MRSA252 gamma-hemolysin component C precursor YP_041860.1 2584636 D 282458 CDS YP_041861.1 49484637 2859642 2585585..2586562 1 NC_002952.2 Identical to Staphylococcus aureus HlgB-like precursor Luk F-R TR:Q57227 (EMBL:X81586) (325 aa) fasta scores: E(): 1.4e-125, 100% id in 325 aa. Similar to Staphylococcus aureus leukocidin F subunit precursor LukF SW:LUKF_STAAU (P31715) (323 aa) fasta scores: E(): 1.5e-119, 96.3% id in 325 aa; gamma-hemolysin component C precursor 2586562 hlgB 2859642 hlgB Staphylococcus aureus subsp. aureus MRSA252 gamma-hemolysin component C precursor YP_041861.1 2585585 D 282458 CDS YP_041862.1 49484638 2859974 complement(2586614..2587081) 1 NC_002952.2 Similar to Bacillus sphaericus hypothetical protein BioX SW:BIOX_BACSH (P22821) (166 aa) fasta scores: E(): 2.6e-15, 40% id in 145 aa, and to Streptococcus pyogenes hypothetical protein SPY0373 TR:Q9A1A8 (EMBL:AE006500) (187 aa) fasta scores: E(): 1.2, 27.95% id in 161 aa; hypothetical protein 2587081 2859974 SAR2512 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041862.1 2586614 R 282458 CDS YP_041863.1 49484639 2859975 complement(2587092..2587784) 1 NC_002952.2 catalyzes the formation of pimeloyl-CoA from pimelate and coenzyme A; 6-carboxyhexanoate--CoA ligase 2587784 2859975 SAR2513 Staphylococcus aureus subsp. aureus MRSA252 6-carboxyhexanoate--CoA ligase YP_041863.1 2587092 R 282458 CDS YP_041864.1 49484640 2859976 complement(2587795..2588910) 1 NC_002952.2 Similar to Bacillus subtilis 8-amino-7-oxononanoate synthase BioF SW:BIOF_BACSU (P53556) (389 aa) fasta scores: E(): 2.6e-29, 29.63% id in 378 aa, and to Bacillus sphaericus 8-amino-7-oxononanoate synthase BioF SW:BIOF_BACSH (P22806) (389 aa) fasta scores: E(): 2.5e-27, 29.45% id in 370 aa; 8-amino-7-oxononanoate synthase 2588910 2859976 SAR2514 Staphylococcus aureus subsp. aureus MRSA252 8-amino-7-oxononanoate synthase YP_041864.1 2587795 R 282458 CDS YP_041865.1 49484641 2858971 complement(2588888..2589895) 1 NC_002952.2 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 2589895 bioB 2858971 bioB Staphylococcus aureus subsp. aureus MRSA252 biotin synthase YP_041865.1 2588888 R 282458 CDS YP_041866.1 49484642 2858970 complement(2589897..2591255) 1 NC_002952.2 Similar to Bacillus subtilis adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA SW:BIOA_BACSU (P53555) (448 aa) fasta scores: E(): 3.6e-83, 48.43% id in 446 aa, and to Bacillus sphaericus adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA SW:BIOA_BACSH (P22805) (455 aa) fasta scores: E(): 2.2e-63, 36.44% id in 450 aa; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 2591255 bioA 2858970 bioA Staphylococcus aureus subsp. aureus MRSA252 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_041866.1 2589897 R 282458 CDS YP_041867.1 49484643 2859977 complement(2591233..2591919) 1 NC_002952.2 Similar to Bacillus sphaericus dethiobiotin synthetase BioD SW:BIOD_BACSH (P22818) (234 aa) fasta scores: E(): 7.1e-11, 29.3% id in 215 aa, and to Bacillus subtilis dethiobiotin synthetase BioD SW:BIOD_BACSU (P53558) (231 aa) fasta scores: E(): 4.5e-07, 28.42% id in 197 aa; dethiobiotin synthetase 2591919 2859977 SAR2517 Staphylococcus aureus subsp. aureus MRSA252 dethiobiotin synthetase YP_041867.1 2591233 R 282458 CDS YP_041868.1 49484644 2859978 complement(2592372..2594105) 1 NC_002952.2 Similar to Proteus mirabilis NrpA hypothetical protein TR:Q9ZB58 (EMBL:U46488) (588 aa) fasta scores: E(): 1.2e-51, 33.79% id in 577 aa, and to Thermotoga maritima hypothetical ABC transporter ATP-binding protein TM0288 SW:Y288_THEMA (Q9WYC4) (598 aa) fasta scores: E(): 5.7e-45, 31.87% id in 571 aa; ABC transporter ATP-binding protein 2594105 2859978 SAR2518 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041868.1 2592372 R 282458 CDS YP_041869.1 49484645 2859979 complement(2594130..2595914) 1 NC_002952.2 Similar to Zymomonas mobilis lipoprotein inner membrane ABC-transporter TR:Q9REN6 (EMBL:AF213822) (599 aa) fasta scores: E(): 1.2e-53, 33.91% id in 575 aa, and to Streptomyces coelicolor ABC transporter ATP-binding protein SC4C2.24 TR:Q9EWN8 (EMBL:AL450432) (608 aa) fasta scores: E(): 2.6e-52, 34.04% id in 564 aa; ABC transporter ATP-binding protein 2595914 2859979 SAR2519 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041869.1 2594130 R 282458 CDS YP_041870.1 49484646 2859980 complement(2596407..2596514) 1 NC_002952.2 Doubtful CDS; hypothetical protein 2596514 2859980 SAR2519a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041870.1 2596407 R 282458 CDS YP_041871.1 49484647 2859981 2596545..2596799 1 NC_002952.2 Doubtful CDS. No significant database matches; hypothetical protein 2596799 2859981 SAR2520 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041871.1 2596545 D 282458 CDS YP_041872.1 49484648 2859982 complement(2596782..2597168) 1 NC_002952.2 Similar to Listeria monocytogenes cell wall teichoic acid glycosylation protein GtcA SW:GTCA_LISMO (Q9ZH29) (123 aa) fasta scores: E(): 0.00074, 28.92% id in 121 aa, and to Streptomyces coelicolor sugar translocase 2SCK8.02 TR:Q9AK50 (EMBL:AL589164) (148 aa) fasta scores: E(): 1.5e-14, 41.37% id in 116 aa; hypothetical protein 2597168 2859982 SAR2521 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041872.1 2596782 R 282458 CDS YP_041873.1 49484649 2859983 2597436..2598578 1 NC_002952.2 Similar to Escherichia coli glycerate kinase 1 GlxK SW:GRK1_ECOLI (P77364) (381 aa) fasta scores: E(): 4.9e-61, 46.93% id in 375 aa, and to Bacillus halodurans glycerate kinase BH0555 SW:GRK_BACHD (Q9Z9P2) (380 aa) fasta scores: E(): 1.1e-68, 50.26% id in 374 aa; glycerate kinase 2598578 2859983 SAR2522 Staphylococcus aureus subsp. aureus MRSA252 glycerate kinase YP_041873.1 2597436 D 282458 CDS YP_041874.1 49484650 2859984 2598638..2599297 1 NC_002952.2 hypothetical protein 2599297 2859984 SAR2523 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041874.1 2598638 D 282458 CDS YP_041875.1 49484651 2859985 2599479..2600690 1 NC_002952.2 Similar to Staphylococcus aureus teicoplanin resistance associated membrane protein TcaB TR:Q9F4G1 (EMBL:AY008833) (402 aa) fasta scores: E(): 1.7e-62, 47.46% id in 394 aa, and to Escherichia coli bicyclomycin resistance protein Bcr SW:BCR_ECOLI (P28246) (396 aa) fasta scores: E(): 7.1e-30, 28.98% id in 376 aa; transporter protein 2600690 2859985 SAR2524 Staphylococcus aureus subsp. aureus MRSA252 transporter protein YP_041875.1 2599479 D 282458 CDS YP_041876.1 49484652 2859986 complement(2600813..2601286) 1 NC_002952.2 Similar to the C-terminal regions of Lactococcus lactis positive transcriptional activator TR:O87252 (EMBL:AE001272) (265 aa) fasta scores: E(): 1.7e-12, 33.12% id in 157 aa, and Bacillus subtilis probable AraC family transcriptional regulator YdeE TR:P96662 (EMBL:AB001488) (290 aa) fasta scores: E(): 0.35, 21.34% id in 164 aa. Possible gene remnant; hypothetical protein 2601286 2859986 SAR2525 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041876.1 2600813 R 282458 CDS YP_041877.1 49484653 2859987 2601399..2602055 1 NC_002952.2 Similar to the C-terminal regions of Bacillus subtilis hypothetical protein YvpB TR:O34735 (EMBL:AF017113) (250 aa) fasta scores: E(): 0.0011, 26.59% id in 173 aa, and Lactococcus lactis hypothetical protein YxaF TR:Q9CDJ5 (EMBL:AE006451) (225 aa) fasta scores: E(): 0.053, 25.3% id in 166 aa. Possible gene remnant; hypothetical protein 2602055 2859987 SAR2526 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041877.1 2601399 D 282458 CDS YP_041878.1 49484654 2859988 complement(2602118..2602924) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YjjH TR:Q9CGX2 (EMBL:AE006331) (243 aa) fasta scores: E(): 9.5e-06, 26.27% id in 255 aa, and to Bacillus subtilis hypothetical protein YotB TR:O34642 (EMBL:Z99114) (275 aa) fasta scores: E(): 0.0094, 23.55% id in 276 aa; hypothetical protein 2602924 2859988 SAR2527 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041878.1 2602118 R 282458 CDS YP_041879.1 49484655 2859989 2603209..2604618 1 NC_002952.2 Similar to Escherichia coli D-serine/D-alanine/glycine transporter CycA SW:CYCA_ECOLI (P39312) (470 aa) fasta scores: E(): 8.3e-88, 50.44% id in 454 aa, and to Bacillus subtilis hypothetical transport protein YdgF SW:YDGF_BACSU (P96704) (458 aa) fasta scores: E(): 5.1e-87, 51.58% id in 442 aa. Similar to SAR1775, 65.410% identity (65.556% ungapped) in 451 aa overlap; amino acid permease 2604618 2859989 SAR2528 Staphylococcus aureus subsp. aureus MRSA252 amino acid permease YP_041879.1 2603209 D 282458 CDS YP_041880.1 49484656 2859990 2604756..2606834 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YvgP TR:O32212 (EMBL:Z99121) (670 aa) fasta scores: E(): 3.4e-48, 31.06% id in 692 aa, and to Lactococcus lactis Na+/H+ antiporter YdiF TR:Q9CIH7 (EMBL:AE006275) (680 aa) fasta scores: E(): 5.5e-36, 27.32% id in 688 aa; sodium/hydrogen exchanger family protein 2606834 2859990 SAR2529 Staphylococcus aureus subsp. aureus MRSA252 sodium/hydrogen exchanger family protein YP_041880.1 2604756 D 282458 CDS YP_041881.1 49484657 2859991 complement(2606974..2608803) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdaO TR:P96589 (EMBL:AB001488) (607 aa) fasta scores: E(): 3.9e-126, 56.55% id in 610 aa, and to Mycobacterium tuberculosis hypothetical protein MTCY05A6.11c TR:O07192 (EMBL:Z96072) (657 aa) fasta scores: E(): 5.7e-32, 35.33% id in 634 aa; hypothetical protein 2608803 2859991 SAR2530 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041881.1 2606974 R 282458 CDS YP_041882.1 49484658 2859992 2609035..2610534 1 NC_002952.2 Highly similar to Staphylococcus aureus FmtA-like protein Flp TR:Q9KJ74 (EMBL:AF210139) (498 aa) fasta scores: E(): 1.3e-171, 94.76% id in 497 aa. Similar to Bacillus halodurans hypothetical protein BH0715 TR:Q9KEY4 (EMBL:AP001509) (478 aa) fasta scores: E(): 2.2e-21, 26.84% id in 462 aa; hypothetical protein 2610534 2859992 SAR2531 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041882.1 2609035 D 282458 CDS YP_041883.1 49484659 2859993 complement(2610641..2611492) 1 NC_002952.2 Similar to Vibrio cholerae hypothetical protein VC1697 TR:Q9KRE5 (EMBL:AE004247) (276 aa) fasta scores: E(): 0.001, 22.82% id in 276 aa, and to Halobacterium sp hypothetical protein VNG0267H TR:Q9HSE7 (EMBL:AE004989) (297 aa) fasta scores: E(): 2e-06, 25.09% id in 255 aa; hypothetical protein 2611492 2859993 SAR2532 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041883.1 2610641 R 282458 CDS YP_041884.1 49484660 2859994 complement(2611814..2612749) 1 NC_002952.2 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 2612749 2859994 SAR2533 Staphylococcus aureus subsp. aureus MRSA252 2-dehydropantoate 2-reductase YP_041884.1 2611814 R 282458 CDS YP_041885.1 49484661 2858889 complement(2612975..2614375) 1 NC_002952.2 Similar to Pseudomonas aeruginosa probable MFS transporter PA1316 TR:Q9I428 (EMBL:AE004561) (513 aa) fasta scores: E(): 6e-26, 31.45% id in 426 aa, and to Rhizobium loti transmembrane efflux protein MLL5686 TR:BAB52087 (EMBL:AP003007) (502 aa) fasta scores: E(): 1.5e-24, 26.1% id in 429 aa. Similar to SAR0109, 59.913% identity (60.706% ungapped) in 459 aa overlap, and to SAR1448, 57.204% identity (58.079% ungapped) in 465 aa overlap; transport protein 2614375 2858889 SAR2534 Staphylococcus aureus subsp. aureus MRSA252 transport protein YP_041885.1 2612975 R 282458 CDS YP_041886.1 49484662 2860978 complement(2614669..2615364) 1 NC_002952.2 Similar to Bacillus subtilis glycine betaine/carnitine/choline ABC transporter permease OpuCD SW:OPCD_BACSU (O34742) (229 aa) fasta scores: E(): 1.8e-46, 59.25% id in 216 aa, and to Listeria monocytogenes membrane permease OpuCD TR:Q9KHT6 (EMBL:AF249729) (223 aa) fasta scores: E(): 5.1e-46, 61.11% id in 216 aa; glycine betaine/carnitine/choline ABC transporter permease 2615364 opuCD 2860978 opuCD Staphylococcus aureus subsp. aureus MRSA252 glycine betaine/carnitine/choline ABC transporter permease YP_041886.1 2614669 R 282458 CDS YP_041887.1 49484663 2859187 complement(2615364..2616305) 1 NC_002952.2 Similar to Bacillus subtilis glycine betaine/carnitine/choline-binding protein precursor OpuCC SW:OPCC_BACSU (O32243) (303 aa) fasta scores: E(): 3e-65, 56.2% id in 306 aa, and to Listeria monocytogenes substrate binding protein OpuCC TR:Q9KHT7 (EMBL:AF249729) (308 aa) fasta scores: E(): 1e-70, 60.51% id in 309 aa; glycine betaine/carnitine/choline-binding lipoprotein precursor 2616305 opuCC 2859187 opuCC Staphylococcus aureus subsp. aureus MRSA252 glycine betaine/carnitine/choline-binding lipoprotein precursor YP_041887.1 2615364 R 282458 CDS YP_041888.1 49484664 2859186 complement(2616322..2616957) 1 NC_002952.2 Similar to Bacillus subtilis glycine betaine/carnitine/choline ABC transporter permease OpuCB SW:OPCB_BACSU (O34878) (217 aa) fasta scores: E(): 2.6e-39, 51.92% id in 208 aa, and to Listeria monocytogenes membrane permease OpuCB TR:Q9KHT8 (EMBL:AF249729) (218 aa) fasta scores: E(): 1.1e-38, 53.36% id in 208 aa; glycine betaine/carnitine/choline ABC transporter permease 2616957 opuCB 2859186 opuCB Staphylococcus aureus subsp. aureus MRSA252 glycine betaine/carnitine/choline ABC transporter permease YP_041888.1 2616322 R 282458 CDS YP_041889.1 49484665 2859185 complement(2616954..2618180) 1 NC_002952.2 Similar to Bacillus subtilis glycine betaine/carnitine/choline transport ATP-binding protein OpuCA SW:OPCA_BACSU (O34992) (380 aa) fasta scores: E(): 5.9e-76, 59.2% id in 375 aa, and to Listeria monocytogenes ATPase OpuCA TR:Q9KHT9 (EMBL:AF249729) (397 aa) fasta scores: E(): 4.5e-81, 60.56% id in 393 aa; glycine betaine/carnitine/choline transport ATP-binding protein 2618180 opuCA 2859185 opuCA Staphylococcus aureus subsp. aureus MRSA252 glycine betaine/carnitine/choline transport ATP-binding protein YP_041889.1 2616954 R 282458 CDS YP_041890.1 49484666 2859189 complement(2618850..2619449) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2088 TR:Q9Z9R5 (EMBL:AB013367) (197 aa) fasta scores: E(): 4.4e-37, 55.05% id in 198 aa, and to Bacillus subtilis hypothetical protein YdeI TR:P96666 (EMBL:AB001488) (197 aa) fasta scores: E(): 1.2e-35, 54.54% id in 198 aa; hypothetical protein 2619449 2859189 SAR2539 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041890.1 2618850 R 282458 CDS YP_041891.1 49484667 2859190 2619630..2621267 1 NC_002952.2 Similar to Bacillus subtilis YbeC TR:Q45577 (EMBL:Z99105) (539 aa) fasta scores: E(): 5.7e-102, 48.23% id in 539 aa, and to Thermoplasma acidophilum L-asparagine permease related protein TA0427 TR:Q9HL13 (EMBL:AL445064) (557 aa) fasta scores: E(): 2.6e-56, 32.38% id in 525 aa; amino acid permease 2621267 2859190 SAR2540 Staphylococcus aureus subsp. aureus MRSA252 amino acid permease YP_041891.1 2619630 D 282458 CDS YP_041892.1 49484668 2859191 2621574..2622926 1 NC_002952.2 Similar to Bacillus subtilis para-nitrobenzyl esterase PnbA SW:PNBA_BACSU (P37967) (489 aa) fasta scores: E(): 6.2e-31, 32.54% id in 464 aa, and to Bacillus sp BP-7 type B carboxylesterase EstA1 TR:Q9L378 (EMBL:AJ278066) (486 aa) fasta scores: E(): 1.1e-31, 31.6% id in 462 aa; carboxylesterase 2622926 2859191 SAR2541 Staphylococcus aureus subsp. aureus MRSA252 carboxylesterase YP_041892.1 2621574 D 282458 CDS YP_041893.1 49484669 2859192 complement(2622988..2624175) 1 NC_002952.2 Similar to Pseudomonas aeruginosa probable MFS transporter PA3303 TR:Q9HYU1 (EMBL:AE004752) (391 aa) fasta scores: E(): 1.8e-29, 33.05% id in 363 aa, and to Bacillus subtilis hypothetical protein YdhL TR:O05504 (EMBL:D88802) (425 aa) fasta scores: E(): 1e-28, 30.76% id in 377 aa; transport protein 2624175 2859192 SAR2542 Staphylococcus aureus subsp. aureus MRSA252 transport protein YP_041893.1 2622988 R 282458 CDS YP_041894.1 49484670 2859193 complement(2624569..2625345) 1 NC_002952.2 Similar to Escherichia coli hypothetical protein YbbM SW:YBBM_ECOLI (P77307) (259 aa) fasta scores: E(): 5.2e-38, 45.96% id in 248 aa, and to Bacillus subtilis hypothetical protein YjkA TR:O34684 (EMBL:AF015825) (250 aa) fasta scores: E(): 6.3e-21, 32.12% id in 249 aa; hypothetical protein 2625345 2859193 SAR2543 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041894.1 2624569 R 282458 CDS YP_041895.1 49484671 2859194 complement(2625338..2626000) 1 NC_002952.2 Similar to Escherichia coli hypothetical ABC transporter ATP-binding protein YbbL SW:YBBL_ECOLI (P77279) (225 aa) fasta scores: E(): 3.5e-23, 42.92% id in 205 aa, and to Methanococcus jannaschii hypothetical ABC transporter ATP-binding protein MJ1508 SW:YF08_METJA (Q58903) (224 aa) fasta scores: E(): 1e-15, 36.63% id in 202 aa; ABC transporter ATP-binding protein 2626000 2859194 SAR2544 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041895.1 2625338 R 282458 CDS YP_041896.1 49484672 2859195 complement(2626346..2627422) 1 NC_002952.2 Similar to Lactococcus lactis glutamyl-aminopeptidase PepA SW:PEPA_LACLC (Q48677) (355 aa) fasta scores: E(): 2.7e-39, 37.39% id in 353 aa, and to Bacillus subtilis hypothetical protein YsdC TR:P94521 (EMBL:Z75208) (361 aa) fasta scores: E(): 2.7e-71, 52.08% id in 359 aa; hypothetical protein 2627422 2859195 SAR2545 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041896.1 2626346 R 282458 CDS YP_041897.1 49484673 2859196 2627660..2628115 1 NC_002952.2 Similar to Listeria monocytogenes hypothetical lipoprotein precursor SW:YORZ_LISMO (P33385) (153 aa) fasta scores: E(): 7.9e-12, 40.39% id in 151 aa, and to Escherichia coli hypothetical lipoprotein precursor YehR SW:YEHR_ECOLI (P33354) (153 aa) fasta scores: E(): 1.8e-08, 34.89% id in 149 aa; lipoprotein 2628115 2859196 SAR2546 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_041897.1 2627660 D 282458 CDS YP_041898.1 49484674 2859197 complement(2628283..2629860) 1 NC_002952.2 Similar to Bacillus subtilis YerD TR:O34849 (EMBL:Z99107) (525 aa) fasta scores: E(): 4.4e-112, 56.27% id in 526 aa, and to Pseudomonas aeruginosa hypothetical protein PA3602 TR:Q9HY24 (EMBL:AE004780) (536 aa) fasta scores: E(): 5.4e-45, 35.52% id in 518 aa; hypothetical protein 2629860 2859197 SAR2547 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041898.1 2628283 R 282458 CDS YP_041899.1 49484675 2859198 2630056..2630805 1 NC_002952.2 Similar to Bacillus anthracis plasmid pXO2 hypothetical protein pXO2-46 TR:Q9RMY6 (EMBL:AF188935) (221 aa) fasta scores: E(): 0.29, 22.17% id in 230 aa, and to Bacillus subtilis hypothetical protein YybL SW:YYBL_BACSU (P37492) (236 aa) fasta scores: E(): 0.31, 21.88% id in 233 aa; hypothetical protein 2630805 2859198 SAR2548 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041899.1 2630056 D 282458 CDS YP_041900.1 49484676 2859199 complement(2631029..2632222) 1 NC_002952.2 Similar to Bacillus subtilis multidrug resistance protein 2 Bmr2 SW:BMR2_BACSU (P39843) (400 aa) fasta scores: E(): 2.7e-07, 22.82% id in 390 aa, and to Bacillus halodurans hypothetical protein BH2079 TR:Q9KB52 (EMBL:AP001514) (392 aa) fasta scores: E(): 1.1e-76, 55.46% id in 384 aa; transporter 2632222 2859199 SAR2549 Staphylococcus aureus subsp. aureus MRSA252 transporter YP_041900.1 2631029 R 282458 CDS YP_041901.1 49484677 2859180 complement(2632234..2632983) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus oligopeptide transporter ATPase domain Opp-1F TR:Q9ZGN8 (EMBL:AF076683) (251 aa) fasta scores: E(): 8.5e-88, 100% id in 249 aa. Similar to Escherichia coli peptide transport system ATP-binding protein SapF SW:SAPF_ECOLI (P36637) (268 aa) fasta scores: E(): 4.6e-24, 34.67% id in 248 aa; oligopeptide transporter ATPase 2632983 opp-1F 2859180 opp-1F Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transporter ATPase YP_041901.1 2632234 R 282458 CDS YP_041902.1 49484678 2859179 complement(2632976..2633791) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus oligopeptide transporter ATPase domain Opp-1D TR:Q9ZGN9 (EMBL:AF076683) (271 aa) fasta scores: E(): 8.5e-90, 97.41% id in 271 aa. Similar to Bacillus subtilis oligopeptide transport ATP-binding protein OppD SW:OPPD_BACSU (P24136) (358 aa) fasta scores: E(): 6e-32, 42.35% id in 255 aa; oligopeptide transporter ATPase 2633791 opp-1D 2859179 opp-1D Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transporter ATPase YP_041902.1 2632976 R 282458 CDS YP_041903.1 49484679 2859178 complement(2633788..2634657) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus oligopeptide transporter membrane permease domain Opp-1C TR:Q9ZGP0 (EMBL:AF076683) (289 aa) fasta scores: E(): 6.6e-107, 100% id in 289 aa. Similar to Escherichia coli nickel ABC transporter permease NikC SW:NIKC_ECOLI (P33592) (277 aa) fasta scores: E(): 6.6e-34, 36.64% id in 262 aa; oligopeptide transporter membrane permease 2634657 opp-1C 2859178 opp-1C Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transporter membrane permease YP_041903.1 2633788 R 282458 CDS YP_041904.1 49484680 2859177 complement(2634654..2635589) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus oligopeptide transporter membrane permease domain Opp-1B TR:Q9ZGP1 (EMBL:AF076683) (311 aa) fasta scores: E(): 7.1e-116, 99.67% id in 311 aa. Similar to Escherichia coli nickel ABC transporter permease NikB SW:NIKB_ECOLI (P33591) (314 aa) fasta scores: E(): 1.2e-37, 34.82% id in 313 aa; oligopeptide transporter membrane permease 2635589 opp-1B 2859177 opp-1B Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transporter membrane permease YP_041904.1 2634654 R 282458 CDS YP_041905.1 49484681 2859176 complement(2635602..2637200) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus oligopeptide transporter substrate binding domain Opp-1A TR:Q9ZGP2 (EMBL:AF076683) (486 aa) fasta scores: E(): 1.4e-175, 99.58% id in 486 aa. Similar to Bacillus halodurans nickel transport system BH0567 TR:Q9KFB8 (EMBL:AP001509) (539 aa) fasta scores: E(): 3.1e-62, 38.1% id in 538 aa, and to Escherichia coli nickel-binding periplasmic protein precursor NikA SW:NIKA_ECOLI (P33590) (524 aa) fasta scores: E(): 1.7e-56, 34.82% id in 491 aa. CDS is extended at the N-terminus in comparison previously sequenced protein; oligopeptide transporter substrate binding protein 2637200 opp-1A 2859176 opp-1A Staphylococcus aureus subsp. aureus MRSA252 oligopeptide transporter substrate binding protein YP_041905.1 2635602 R 282458 CDS YP_041906.1 49484682 2859200 complement(2637343..2638644) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2073 TR:Q9KB58 (EMBL:AP001514) (436 aa) fasta scores: E(): 2.6e-76, 47.75% id in 423 aa, and to Pseudomonas aeruginosa hypothetical protein PA4835 TR:Q9HUX5 (EMBL:AE004896) (433 aa) fasta scores: E(): 6.2e-41, 31.34% id in 418 aa; hypothetical protein 2638644 2859200 SAR2555 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041906.1 2637343 R 282458 CDS YP_041907.1 49484683 2859201 complement(2638637..2639455) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2072 TR:Q9KB59 (EMBL:AP001514) (264 aa) fasta scores: E(): 7.1e-33, 43.19% id in 257 aa, and to Thermotoga neapolitana hypothetical protein TR:O86951 (EMBL:AJ007446) (258 aa) fasta scores: E(): 0.051, 21.79% id in 257 aa; hypothetical protein 2639455 2859201 SAR2556 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041907.1 2638637 R 282458 CDS YP_041908.1 49484684 2859202 complement(2639466..2640287) 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans BH2071 TR:Q9KB60 (EMBL:AP001514) (277 aa) fasta scores: E(): 1.5e-26, 32.73% id in 278 aa; hypothetical protein 2640287 2859202 SAR2557 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041908.1 2639466 R 282458 CDS YP_041909.1 49484685 2859203 complement(2640989..2641756) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YddR TR:P96655 (EMBL:AB001488) (254 aa) fasta scores: E(): 1.1e-48, 50.39% id in 254 aa, and to Escherichia coli O157:H7 hypothetical protein ECS0400 TR:BAB33823 (EMBL:AP002551) (262 aa) fasta scores: E(): 3.2e-38, 44.01% id in 259 aa; hypothetical protein 2641756 2859203 SAR2558 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041909.1 2640989 R 282458 CDS YP_041910.1 49484686 2859204 complement(2641857..2642675) 1 NC_002952.2 Similar to Escherichia coli oxidoreductase UcpA SW:UCPA_ECOLI (P37440) (285 aa) fasta scores: E(): 4.9e-25, 35.17% id in 253 aa, and to Bacillus subtilis hypothetical oxidoreductase YxbG SW:YXBG_BACSU (P46331) (262 aa) fasta scores: E(): 7.4e-43, 57.14% id in 210 aa. CDS appears to be truncated at the N-terminus in comparison to the E. coli protein; short chain dehydrogenase 2642675 2859204 SAR2559 Staphylococcus aureus subsp. aureus MRSA252 short chain dehydrogenase YP_041910.1 2641857 R 282458 CDS YP_041911.1 49484687 2859205 2642910..2644448 1 NC_002952.2 Similar to Escherichia coli aminobenzoyl-glutamate transport protein AbgT SW:ABGT_ECOLI (P46133) (510 aa) fasta scores: E(): 4.9e-63, 34.64% id in 508 aa, and to Bacillus halodurans hypothetical protein BH0866 TR:Q9KEI6 (EMBL:AP001510) (513 aa) fasta scores: E(): 2e-91, 46.33% id in 505 aa; transporter 2644448 2859205 SAR2560 Staphylococcus aureus subsp. aureus MRSA252 transporter YP_041911.1 2642910 D 282458 CDS YP_041912.1 49484688 2859206 complement(2644560..2644982) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YdfG TR:P96684 (EMBL:AB001488) (147 aa) fasta scores: E(): 2.2e-14, 35.82% id in 134 aa, and to Streptomyces coelicolor hypothetical protein SCE6.22c TR:Q9KZR6 (EMBL:AL353832) (157 aa) fasta scores: E(): 3.2e-09, 31.57% id in 133 aa; hypothetical protein 2644982 2859206 SAR2561 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041912.1 2644560 R 282458 CDS YP_041913.1 49484689 2859207 complement(2645435..2645848) 1 NC_002952.2 No significant database matches. Similar to SAR2566, 78.102% identity (79.259% ungapped) in 137 aa overlap, SAR2565, 75.000% identity (76.119% ungapped) in 136 aa overlap, and to SAR2563, 70.290% identity (71.324% ungapped) in 138 aa overlap; hypothetical protein 2645848 2859207 SAR2562 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041913.1 2645435 R 282458 CDS YP_041914.1 49484690 2859208 complement(2645866..2646285) 1 NC_002952.2 Poor database matches. Similar to an internal region of Oxytricha fallax hypothetical protein TR:P90560 (EMBL:L39908) (193 aa) fasta scores: E(): 4.5, 25% id in 132 aa. Similar to SAR2565, 86.029% identity (86.029% ungapped) in 136 aa overlap, SAR2566, 70.073% identity (70.073% ungapped) in 137 aa overlap, and to SAR2562, 70.290% identity (71.324% ungapped) in 138 aa overlap; hypothetical protein 2646285 2859208 SAR2563 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041914.1 2645866 R 282458 CDS YP_041915.1 49484691 2859210 complement(2646990..2647400) 1 NC_002952.2 Poor database matches. Weakly similar to the C-terminal region of Enterococcus faecium hypothetical protein TR:Q47816 (EMBL:U01917) (105 aa) fasta scores: E(): 7.1, 25% id in 76 aa. Similar to SAR2563, 86.029% identity (86.029% ungapped) in 136 aa overlap , SAR2562, 75.000% identity (76.119% ungapped) in 136 aa overlap, and to SAR2566, 72.059% identity (72.059% ungapped) in 136 aa overlap; hypothetical protein 2647400 2859210 SAR2565 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041915.1 2646990 R 282458 CDS YP_041916.1 49484692 2859211 complement(2647678..2648100) 1 NC_002952.2 Poor database matches. Weakly similar to the C-terminal region of Enterococcus faecium hypothetical protein TR:Q47816 (EMBL:U01917) (105 aa) fasta scores: E(): 6.2, 25.97% id in 77 aa. Similar to SAR2562, 78.102% identity (79.259% ungapped) in 137 aa overlap, SAR2563, 70.073% identity (70.073% ungapped) in 137 aa overlap, and to SAR2565, 72.059% identity (72.059% ungapped) in 136 aa overlap; hypothetical protein 2648100 2859211 SAR2566 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041916.1 2647678 R 282458 CDS YP_041917.1 49484693 2859212 complement(2648352..2649047) 1 NC_002952.2 Similar to Rhizobium meliloti D-beta-hydroxybutyrate dehydrogenase BdhA SW:BDHA_RHIME (O86034) (258 aa) fasta scores: E(): 5.5e-19, 35.68% id in 227 aa, and to Synechocystis sp hypothetical protein SLR0315 TR:Q55922 (EMBL:D64005) (244 aa) fasta scores: E(): 1.8e-25, 41.49% id in 241 aa; short chain dehydrogenase 2649047 2859212 SAR2567 Staphylococcus aureus subsp. aureus MRSA252 short chain dehydrogenase YP_041917.1 2648352 R 282458 CDS YP_041918.1 49484694 2859213 2649346..2649627 1 NC_002952.2 hypothetical protein 2649627 2859213 SAR2568 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041918.1 2649346 D 282458 CDS YP_041919.1 49484695 2859214 complement(2649885..2650076) 1 NC_002952.2 hypothetical protein 2650076 2859214 SAR2569 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041919.1 2649885 R 282458 CDS YP_041920.1 49484696 2859215 complement(2650637..2651431) 1 NC_002952.2 No significant database matches. Similar to SAR2573, 68.992% identity (68.992% ungapped) in 258 aa overlap, SAR0106, 63.320% identity (64.314% ungapped) in 259 aa overlap, SAR0444, 61.923% identity (62.403% ungapped) in 260 aa overlap; hypothetical protein 2651431 2859215 SAR2570 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041920.1 2650637 R 282458 CDS YP_041921.1 49484697 2859217 complement(2652402..2653178) 1 NC_002952.2 No significant database matches. Similar to SAR2570, 69.884% identity (70.428% ungapped) in 259 aa overlap, SAR0444, 63.922% identity (64.427% ungapped) in 255 aa overlap, SAR0106, 59.846% identity (61.265% ungapped) in 259 aa overlap, and to SAR0445, 50.373% identity (52.326% ungapped) in 268 aa overlap; lipoprotein 2653178 2859217 SAR2573 Staphylococcus aureus subsp. aureus MRSA252 lipoprotein YP_041921.1 2652402 R 282458 CDS YP_041922.1 49484698 2859218 complement(2653482..2656343) 1 NC_002952.2 Similar to Streptomyces coelicolor helicase SCE20.37 TR:Q9RD88 (EMBL:AL136058) (945 aa) fasta scores: E(): 2.1e-34, 27.06% id in 968 aa. N-terminus is similar to the N-terminal region of Vibrio cholerae helicase-related protein VC0812 TR:Q9KTS6 (EMBL:AE004166) (979 aa) fasta scores: E(): 1.5e-51, 31.74% id in 712 aa; helicase 2656343 2859218 SAR2574 Staphylococcus aureus subsp. aureus MRSA252 helicase YP_041922.1 2653482 R 282458 CDS YP_041923.1 49484699 2859219 complement(2656345..2656737) 1 NC_002952.2 Similar to Escherichia coli CTP pyrophosphohydrolase NudG SW:NUDG_ECOLI (P77788) (135 aa) fasta scores: E(): 5.4e-12, 38.4% id in 125 aa, and to Clostridium acetobutylicum NUDIX (MutT) family hydrolase/pyrophosphatase CAC2828 TR:Q97FB2 (EMBL:AE007780) (128 aa) fasta scores: E(): 2.6e-10, 33.07% id in 127 aa; NUDIX hydrolase 2656737 2859219 SAR2575 Staphylococcus aureus subsp. aureus MRSA252 NUDIX hydrolase YP_041923.1 2656345 R 282458 CDS YP_041924.1 49484700 2859220 2657004..2658662 1 NC_002952.2 Similar to Mycoplasma pirum phosphomannomutase ManB SW:MANB_MYCPI (P47723) (544 aa) fasta scores: E(): 2.5e-35, 28.64% id in 555 aa, and to Bacillus halodurans phosphomannomutase BH1106 TR:Q9KDV5 (EMBL:AP001510) (578 aa) fasta scores: E(): 1.1e-56, 38.4% id in 539 aa; phosphomannomutase 2658662 2859220 SAR2576 Staphylococcus aureus subsp. aureus MRSA252 phosphomannomutase YP_041924.1 2657004 D 282458 CDS YP_041925.1 49484701 2859221 2658946..2659212 1 NC_002952.2 hypothetical protein 2659212 2859221 SAR2577 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041925.1 2658946 D 282458 CDS YP_041926.1 49484702 2859222 2659356..2659664 1 NC_002952.2 Poor database matches. Weakly similar to the C-terminal region of Lysiphlebus testaceipes NADH dehydrogenase 1 TR:O79074 (EMBL:AF069177) (155 aa) fasta scores: E(): 1.7, 24.27% id in 103 aa. Doubtful CDS; hypothetical protein 2659664 2859222 SAR2578 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041926.1 2659356 D 282458 CDS YP_041927.1 49484703 2859946 complement(2659791..2660657) 1 NC_002952.2 Similar to Bacillus subtilis UTP--glucose-1-phosphate uridylyltransferase GtaB SW:GTAB_BACSU (Q05852) (292 aa) fasta scores: E(): 2.8e-74, 70.62% id in 286 aa, and to Bacillus halodurans UTP-glucose-1-phosphate uridylyltransferase BH3717 TR:Q9K6L2 (EMBL:AP001519) (293 aa) fasta scores: E(): 4e-72, 70.28% id in 286 aa; UTP--glucose-1-phosphate uridylyltransferase 2660657 gtaB 2859946 gtaB Staphylococcus aureus subsp. aureus MRSA252 UTP--glucose-1-phosphate uridylyltransferase YP_041927.1 2659791 R 282458 CDS YP_041928.1 49484704 2860673 complement(2660837..2663734) 1 NC_002952.2 Similar to Staphylococcus aureus fibronectin-binding protein precursor FnbA SW:FNBA_STAAU (P14738) (1018 aa) fasta scores: E(): 3.6e-172, 79.15% id in 1022 aa, and to Staphylococcus aureus fibronectin binding protein B FnbB TR:Q53682 (EMBL:X62992) (940 aa) fasta scores: E(): 1.4e-55, 61.77% id in 1015 aa. Probable LPXTG-sorted surface protein. CDS contains two internal deletions relative to the previously sequenced fibronectin-binding protein precursor FnbA (after residues 786 and 840). Deletions occur in regions containing imperfect repeats; fibronectin-binding protein precursor 2663734 fnbA 2860673 fnbA Staphylococcus aureus subsp. aureus MRSA252 fibronectin-binding protein precursor YP_041928.1 2660837 R 282458 CDS YP_041929.1 49484705 2859223 complement(2663869..2664069) 1 NC_002952.2 No significant database matches. Possible alternative translational start sites; hypothetical protein 2664069 2859223 SAR2581 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041929.1 2663869 R 282458 CDS YP_041930.1 49484706 2859937 complement(2664202..2665560) 1 NC_002952.2 Similar to Bacillus licheniformis gluconate permease GntP SW:GNTP_BACLI (P46832) (448 aa) fasta scores: E(): 1.3e-99, 62.19% id in 447 aa, and to Bacillus subtilis gluconate permease GntP SW:GNTP_BACSU (P12012) (448 aa) fasta scores: E(): 4.7e-99, 62.64% id in 447 aa; gluconate permease 2665560 gntP 2859937 gntP Staphylococcus aureus subsp. aureus MRSA252 gluconate permease YP_041930.1 2664202 R 282458 CDS YP_041931.1 49484707 2859936 complement(2665677..2667230) 1 NC_002952.2 Similar to Bacillus subtilis gluconokinase GntK SW:GNTK_BACSU (P12011) (513 aa) fasta scores: E(): 1.1e-129, 62.45% id in 506 aa, and to Bacillus licheniformis gluconokinase GntK SW:GNTK_BACLI (P46834) (513 aa) fasta scores: E(): 5.3e-129, 61.85% id in 506 aa; gluconokinase 2667230 gntK 2859936 gntK Staphylococcus aureus subsp. aureus MRSA252 gluconokinase YP_041931.1 2665677 R 282458 CDS YP_041932.1 49484708 2859938 complement(2667255..2667935) 1 NC_002952.2 Similar to Bacillus subtilis gluconate operon transcriptional repressor GntR SW:GNTR_BACSU (P10585) (243 aa) fasta scores: E(): 2.5e-37, 46.39% id in 222 aa, and to Bacillus licheniformis gluconate operon transcriptional repressor GntR SW:GNTR_BACLI (P46833) (243 aa) fasta scores: E(): 8.8e-37, 45.49% id in 222 aa; gluconate operon transcriptional repressor 2667935 gntR 2859938 gntR Staphylococcus aureus subsp. aureus MRSA252 gluconate operon transcriptional repressor YP_041932.1 2667255 R 282458 CDS YP_041933.1 49484709 2859224 complement(2668122..2668853) 1 NC_002952.2 Possible pseudogene. Similar to Streptococcus pyogenes transcriptional activator regulator protein SPY1863 TR:Q99Y55 (EMBL:AE006612) (245 aa) fasta scores: E(): 3.4e-20, 32.91% id in 237 aa. N-terminus is similar to the N-terminal region of Bacillus subtilis multidrug-efflux transporter 2 regulator BltR SW:BLTR_BACSU (P39842) (273 aa) fasta scores: E(): 7e-06, 30.57% id in 157 aa. CDS is truncated in comparison to S. aureus orthologues, e.g. SAS2393, due to a possible nonsense mutation after codon 243; MerR family transcriptional regulator 2668853 2859224 SAR2585 Staphylococcus aureus subsp. aureus MRSA252 MerR family transcriptional regulator YP_041933.1 2668122 R 282458 CDS YP_041934.1 49484710 2859225 complement(2669018..2669710) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwaC SW:YWAC_BACSU (P39583) (210 aa) fasta scores: E(): 6.6e-29, 47.84% id in 186 aa, and to Lactococcus lactis hypothetical protein YijE TR:Q9CH66 (EMBL:AE006321) (224 aa) fasta scores: E(): 5.2e-21, 38.37% id in 185 aa; hypothetical protein 2669710 2859225 SAR2586 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041934.1 2669018 R 282458 CDS YP_041935.1 49484711 2859226 complement(2669941..2670429) 1 NC_002952.2 No significant database matches. Possible alternative translational start sites; hypothetical protein 2670429 2859226 SAR2587 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041935.1 2669941 R 282458 CDS YP_041936.1 49484712 2859227 complement(2670496..2672319) 1 NC_002952.2 Poor database matches. Weakly similar to Bacillus subtilis hypothetical protein YvaC TR:O32225 (EMBL:Z99121) (631 aa) fasta scores: E(): 1.6e-27, 25.08% id in 614 aa, and to Escherichia coli hypothetical protein YhfK SW:YHFK_ECOLI (P45537) (696 aa) fasta scores: E(): 2e-07, 24.67% id in 620 aa; hypothetical protein 2672319 2859227 SAR2588 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041936.1 2670496 R 282458 CDS YP_041937.1 49484713 2859228 complement(2672796..2674073) 1 NC_002952.2 Similar to Mycobacterium smegmatis transporter protein TR:Q9RPH4 (EMBL:AF157643) (413 aa) fasta scores: E(): 3.7e-28, 30.38% id in 418 aa, and to Bacillus subtilis hypothetical transport protein YybO SW:YYBO_BACSU (P37489) (435 aa) fasta scores: E(): 4.2e-27, 25.72% id in 412 aa; transporter protein 2674073 2859228 SAR2589 Staphylococcus aureus subsp. aureus MRSA252 transporter protein YP_041937.1 2672796 R 282458 CDS YP_041938.1 49484714 2859229 2674624..2675235 1 NC_002952.2 Similar to Lactococcus lactis alkaline phosphatase Apl TR:Q9CHL6 (EMBL:AE006305) (214 aa) fasta scores: E(): 1.2e-28, 42% id in 200 aa, and to Synechocystis sp alkaline phosphatase-like protein SLR0509 TR:Q55829 (EMBL:D64004) (205 aa) fasta scores: E(): 3.8e-23, 35.78% id in 204 aa; DedA family protein 2675235 2859229 SAR2590 Staphylococcus aureus subsp. aureus MRSA252 DedA family protein YP_041938.1 2674624 D 282458 CDS YP_041939.1 49484715 2859230 complement(2675466..2676083) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YisU TR:O06730 (EMBL:Y09476) (220 aa) fasta scores: E(): 9e-35, 52.85% id in 193 aa, and to Bacillus halodurans hypothetical protein BH0431 TR:Q9KFP7 (EMBL:AP001508) (200 aa) fasta scores: E(): 9.2e-29, 43.75% id in 192 aa. SAR0857, 63.415% identity (63.415% ungapped) in 205 aa overlap; LysE type translocator 2676083 2859230 SAR2591 Staphylococcus aureus subsp. aureus MRSA252 LysE type translocator YP_041939.1 2675466 R 282458 CDS YP_041940.1 49484716 2859995 complement(2676080..2677060) 1 NC_002952.2 Poor database matches. Similar to Bradyrhizobium japonicum hypothetical protein ID867 TR:Q9AMU2 (EMBL:AF322013) (352 aa) fasta scores: E(): 1.4e-22, 30.96% id in 323 aa, and to Caulobacter crescentus hypothetical protein CC3422 TR:Q9A2Y4 (EMBL:AE006002) (329 aa) fasta scores: E(): 1.2e-14, 26.15% id in 302 aa; fatty acid desaturase 2677060 2859995 SAR2592 Staphylococcus aureus subsp. aureus MRSA252 fatty acid desaturase YP_041940.1 2676080 R 282458 CDS YP_041941.1 49484717 2859996 2677159..2678571 1 NC_002952.2 Similar to Bacillus halodurans transcriptional regulator BH0432 TR:Q9KFP6 (EMBL:AP001508) (482 aa) fasta scores: E(): 2.2e-66, 39.4% id in 467 aa, and to Bacillus subtilis hypothetical protein YdfD TR:P96681 (EMBL:AB001488) (482 aa) fasta scores: E(): 1.1e-56, 35.88% id in 471 aa; transcriptional regulator 2678571 2859996 SAR2593 Staphylococcus aureus subsp. aureus MRSA252 transcriptional regulator YP_041941.1 2677159 D 282458 CDS YP_041942.1 49484718 2859997 2679257..2679952 1 NC_002952.2 Similar to Staphylococcus epidermidis ABC transporter StpA TR:Q54138 (EMBL:Z30586) (231 aa) fasta scores: E(): 8.6e-59, 85.71% id in 231 aa, and to Staphylococcus hominis potential ABC transporter StpB TR:Q54314 (EMBL:Z30587) (231 aa) fasta scores: E(): 8.6e-59, 85.71% id in 231 aa; ABC transporter ATP-binding protein 2679952 2859997 SAR2594 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_041942.1 2679257 D 282458 CDS YP_041943.1 49484719 2859998 2679954..2680724 1 NC_002952.2 Similar to Staphylococcus hominis potential membrane spanning protein SmpB TR:Q54315 (EMBL:Z30587) (256 aa) fasta scores: E(): 4.1e-60, 67.57% id in 256 aa, and to Staphylococcus epidermidis membrane spanning protein SmpA TR:Q54139 (EMBL:Z30586) (256 aa) fasta scores: E(): 6.2e-60, 66.4% id in 256 aa; hypothetical protein 2680724 2859998 SAR2595 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041943.1 2679954 D 282458 CDS YP_041944.1 49484720 2859999 2681229..2683193 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YydE TR:Q45597 (EMBL:D78193) (671 aa) fasta scores: E(): 8.8e-178, 69.45% id in 645 aa, and to Lactobacillus rhamnosus hypothetical protein TR:AAK64293 (EMBL:AF323526) (656 aa) fasta scores: E(): 6.1e-131, 53.39% id in 633 aa; hypothetical protein 2683193 2859999 SAR2596 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041944.1 2681229 D 282458 CDS YP_041945.1 49484721 2858890 2683537..2684616 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkvI TR:O31674 (EMBL:Z99111) (347 aa) fasta scores: E(): 1.5e-17, 25% id in 348 aa, and to the N-terminal region of Corynebacterium glutamicum branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_CORGL (O06754) (426 aa) fasta scores: E(): 0.12, 22.35% id in 349 aa; hypothetical protein 2684616 2858890 SAR2597 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041945.1 2683537 D 282458 CDS YP_041946.1 49484722 2858891 complement(2684721..2685317) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2174 TR:Q9KAW2 (EMBL:AP001514) (204 aa) fasta scores: E(): 7.4e-29, 41.93% id in 186 aa, and to Bacillus subtilis hypothetical protein YolF TR:O34842 (EMBL:AF006665) (200 aa) fasta scores: E(): 1.2e-25, 41.93% id in 186 aa; phospholipase/carboxylesterase 2685317 2858891 SAR2598 Staphylococcus aureus subsp. aureus MRSA252 phospholipase/carboxylesterase YP_041946.1 2684721 R 282458 CDS YP_041947.1 49484723 2858892 complement(2685336..2686304) 1 NC_002952.2 Similar to Flavobacterium sp 2,6-dichloro-p-hydroquinone 1,2-dioxygenase PcpA TR:Q9ZBB0 (EMBL:M55159) (320 aa) fasta scores: E(): 5.6e-19, 29.46% id in 319 aa, and to Bacillus halodurans hypothetical protein BH2175 TR:Q9KAW1 (EMBL:AP001514) (327 aa) fasta scores: E(): 1.7e-58, 48.75% id in 320 aa; dioxygenase 2686304 2858892 SAR2599 Staphylococcus aureus subsp. aureus MRSA252 dioxygenase YP_041947.1 2685336 R 282458 CDS YP_041948.1 49484724 2858893 complement(2686382..2686816) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YkvE TR:O31672 (EMBL:Z99111) (145 aa) fasta scores: E(): 1.2e-16, 41.79% id in 134 aa, and to Streptococcus pyogenes transcriptional regulator SPY1960 TR:Q99XY5 (EMBL:AE006619) (142 aa) fasta scores: E(): 1.6e-11, 35.76% id in 137 aa; MarR family regulatory protein 2686816 2858893 SAR2600 Staphylococcus aureus subsp. aureus MRSA252 MarR family regulatory protein YP_041948.1 2686382 R 282458 CDS YP_041949.1 49484725 2858894 2687033..2687326 1 NC_002952.2 Similar to Escherichia coli hypothetical protein YjdJ SW:YJDJ_ECOLI (P39274) (90 aa) fasta scores: E(): 3.7e-11, 45.45% id in 88 aa, and to Lactococcus lactis YjdJ-like protein TR:O69438 (EMBL:Y13384) (105 aa) fasta scores: E(): 4.3e-06, 39.32% id in 89 aa; acetyltransferase (GNAT) family protein 2687326 2858894 SAR2601 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_041949.1 2687033 D 282458 CDS YP_041950.1 49484726 2858895 2687501..2688307 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3305 TR:Q9K7Q6 (EMBL:AP001518) (286 aa) fasta scores: E(): 5.3e-34, 41.15% id in 243 aa, and to Rhizobium loti hypothetical protein MLR0078 TR:BAB47738 (EMBL:AP002994) (270 aa) fasta scores: E(): 1.5e-29, 35.45% id in 251 aa; glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein 2688307 2858895 SAR2602 Staphylococcus aureus subsp. aureus MRSA252 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein YP_041950.1 2687501 D 282458 CDS YP_041951.1 49484727 2859266 2689369..2690361 1 NC_002952.2 catalyzes the formation of pyruvate from lactate; D-lactate dehydrogenase 2690361 ddh 2859266 ddh Staphylococcus aureus subsp. aureus MRSA252 D-lactate dehydrogenase YP_041951.1 2689369 D 282458 CDS YP_041952.1 49484728 2858898 complement(2691460..2692260) 1 NC_002952.2 Similar to Escherichia coli hypothetical protein YbjI SW:YBJI_ECOLI (P75809) (271 aa) fasta scores: E(): 6.3e-28, 36.7% id in 267 aa, and to Escherichia coli hypothetical protein YbiV SW:YBIV_ECOLI (P75792) (271 aa) fasta scores: E(): 1.3e-26, 36.84% id in 266 aa; haloacid dehalogenase-like hydrolase 2692260 2858898 SAR2607 Staphylococcus aureus subsp. aureus MRSA252 haloacid dehalogenase-like hydrolase YP_041952.1 2691460 R 282458 CDS YP_041953.1 49484729 2859502 complement(2692490..2693110) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus, peptidoglycan-anchored surface protein processing enzyme, sortase SrtA TR:Q9S446 (EMBL:AF162687) (206 aa) fasta scores: E(): 4e-71, 99.02% id in 206 aa. Similar to Bacillus halodurans hypothetical protein BH2015 TR:Q9KBB3 (EMBL:AP001514) (193 aa) fasta scores: E(): 5.4e-07, 29.83% id in 181 aa; sortase 2693110 srtA 2859502 srtA Staphylococcus aureus subsp. aureus MRSA252 sortase YP_041953.1 2692490 R 282458 CDS YP_041954.1 49484730 2858899 2693304..2693795 1 NC_002952.2 Similar to Streptomyces coelicolor phosphinothricin N-acetyltransferase Bar SW:PAT_STRCO (P21861) (171 aa) fasta scores: E(): 5.6e-14, 33.74% id in 163 aa, and to Pseudomonas aeruginosa hypothetical protein PA4866 TR:Q9HUU7 (EMBL:AE004900) (172 aa) fasta scores: E(): 3.1e-26, 46.58% id in 161 aa; acetyltransferase (GNAT) family protein 2693795 2858899 SAR2609 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_041954.1 2693304 D 282458 CDS YP_041955.1 49484731 2858900 complement(2694594..2695493) 1 NC_002952.2 Similar to Peptostreptococcus asaccharolyticus L-serine dehydratase, alpha chain SdhA SW:SDHA_PEPAS (P33073) (292 aa) fasta scores: E(): 1.7e-38, 44.4% id in 286 aa, and to Bacillus subtilis probable L-serine dehydratase, alpha chain YlpA SW:SDHA_BACSU (O34607) (300 aa) fasta scores: E(): 3.1e-58, 58.56% id in 292 aa; L-serine dehydratase subunit alpha 2695493 2858900 SAR2610 Staphylococcus aureus subsp. aureus MRSA252 L-serine dehydratase subunit alpha YP_041955.1 2694594 R 282458 CDS YP_041956.1 49484732 2858901 complement(2695507..2696187) 1 NC_002952.2 N-terminus is similar to the N-terminal region of Peptostreptococcus asaccharolyticus L-serine dehydratase, beta chain SdhB SW:SDHB_PEPAS (P33074) (222 aa) fasta scores: E(): 2.6e-17, 44.89% id in 147 aaSimilar to the full length Bacillus subtilis probable L-serine dehydratase, beta chain YloW SW:SDHB_BACSU (O34635) (220 aa) fasta scores: E(): 7.5e-23, 42.03% id in 226 aa; L-serine dehydratase subunit beta 2696187 2858901 SAR2611 Staphylococcus aureus subsp. aureus MRSA252 L-serine dehydratase subunit beta YP_041956.1 2695507 R 282458 CDS YP_041957.1 49484733 2858902 complement(2696190..2697233) 1 NC_002952.2 Similar to Streptococcus pyogenes regulatory protein SPY0146 TR:Q9A1Q9 (EMBL:AE006484) (339 aa) fasta scores: E(): 5.5e-45, 43.5% id in 331 aa, and to an internal region of Streptococcus pyogenes sucrose-specific PTS permease, enzyme II SPY1815 TR:Q99Y91 (EMBL:AE006608) (620 aa) fasta scores: E(): 0.0098, 25.51% id in 341 aa; hypothetical protein 2697233 2858902 SAR2612 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041957.1 2696190 R 282458 CDS YP_041958.1 49484734 2858903 2697783..2697986 1 NC_002952.2 hypothetical protein 2697986 2858903 SAR2613 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041958.1 2697783 D 282458 CDS YP_041959.1 49484735 2858904 2698179..2699105 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0725 TR:Q9KEX4 (EMBL:AP001509) (312 aa) fasta scores: E(): 2.2e-47, 45.94% id in 296 aa, and to Bacillus subtilis hypothetical protein YdeD SW:YDED_BACSU (P96661) (319 aa) fasta scores: E(): 9.1e-46, 44.26% id in 305 aa; hypothetical protein 2699105 2858904 SAR2614 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041959.1 2698179 D 282458 CDS YP_041960.1 49484736 2858905 complement(2699186..2700154) 1 NC_002952.2 Similar to Streptococcus pyogenes esterase SPY1718 TR:Q99YG3 (EMBL:AE006601) (328 aa) fasta scores: E(): 7.6e-30, 33.66% id in 300 aa, and to Streptococcus pyogenes esterase SPY1308 TR:Q99ZB0 (EMBL:AE006570) (327 aa) fasta scores: E(): 2.7e-24, 29.28% id in 321 aa; hypothetical protein 2700154 2858905 SAR2615 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041960.1 2699186 R 282458 CDS YP_041961.1 49484737 2858906 complement(2700275..2700631) 1 NC_002952.2 Similar to Schizosaccharomyces pombe thioredoxin II TRX2 SW:TRX2_SCHPO (O14463) (102 aa) fasta scores: E(): 0.0049, 25.3% id in 83 aa, and to Bacillus subtilis hypothetical protein YdfQ TR:P96695 (EMBL:AB001488) (112 aa) fasta scores: E(): 2.8e-12, 38.38% id in 99 aa; hypothetical protein 2700631 2858906 SAR2616 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041961.1 2700275 R 282458 CDS YP_041962.1 49484738 2858907 complement(2700673..2701083) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH2288 TR:Q9KAJ9 (EMBL:AP001515) (143 aa) fasta scores: E(): 0.0003, 29.5% id in 122 aa, and to Vibrio cholerae hypothetical protein VC1938 TR:Q9KQR0 (EMBL:AE004269) (149 aa) fasta scores: E(): 0.00043, 26.98% id in 126 aa; hypothetical protein 2701083 2858907 SAR2617 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041962.1 2700673 R 282458 CDS YP_041963.1 49484739 2859917 complement(2701463..2703529) 1 NC_002952.2 Similar to Bacillus subtilis PTS system, glucose-specific IIABC component PtsG SW:PTGA_BACSU (P20166) (699 aa) fasta scores: E(): 3.4e-121, 59.29% id in 683 aa, and to Staphylococcus carnosus PTS system, glucose-specific IIABC component GlcB TR:Q53922 (EMBL:X93360) (692 aa) fasta scores: E(): 2e-193, 74.09% id in 687 aa. Similar to SAR0190, 59.584% identity (61.692% ungapped) in 673 aa overlap; PTS system, glucose-specific IIABC component 2703529 glcB 2859917 glcB Staphylococcus aureus subsp. aureus MRSA252 PTS system, glucose-specific IIABC component YP_041963.1 2701463 R 282458 CDS YP_041964.1 49484740 2858908 complement(2703829..2705568) 1 NC_002952.2 catalyzes the formation of acetyl phosphate from pyruvate; pyruvate oxidase 2705568 2858908 SAR2619 Staphylococcus aureus subsp. aureus MRSA252 pyruvate oxidase YP_041964.1 2703829 R 282458 CDS YP_041965.1 49484741 2858909 complement(2705608..2706297) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3268 TR:Q9K7U1 (EMBL:AP001518) (227 aa) fasta scores: E(): 5e-24, 36.23% id in 218 aa, and to Escherichia coli hypothetical protein YohK SW:YOHK_ECOLI (P33373) (231 aa) fasta scores: E(): 3.7e-23, 35.29% id in 221 aa; hypothetical protein 2706297 2858909 SAR2620 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041965.1 2705608 R 282458 CDS YP_041966.1 49484742 2858910 complement(2706290..2706685) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwbH SW:YWBH_BACSU (P39591) (128 aa) fasta scores: E(): 1.9e-09, 31.25% id in 128 aa, and to Lactococcus lactis hypothetical protein YhhD TR:Q9CHG9 (EMBL:AE006310) (134 aa) fasta scores: E(): 8.4e-09, 35.39% id in 113 aa; hypothetical protein 2706685 2858910 SAR2621 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041966.1 2706290 R 282458 CDS YP_041967.1 49484743 2858911 complement(2706899..2707777) 1 NC_002952.2 Similar to Bacillus subtilis transcriptional regulatory protein GltC SW:GLTC_BACSU (P20668) (300 aa) fasta scores: E(): 4.2e-20, 26.89% id in 290 aa, and to Bacillus subtilis hypothetical transcriptional regulator YwbI SW:YWBI_BACSU (P39592) (301 aa) fasta scores: E(): 8.5e-40, 38.01% id in 292 aa; LysR family regulatory protein 2707777 2858911 SAR2622 Staphylococcus aureus subsp. aureus MRSA252 LysR family regulatory protein YP_041967.1 2706899 R 282458 CDS YP_041968.1 49484744 2858912 2707944..2708162 1 NC_002952.2 hypothetical protein 2708162 2858912 SAR2623 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041968.1 2707944 D 282458 CDS YP_041969.1 49484745 2858913 2708550..2708981 1 NC_002952.2 Similar to the C-terminal regions of Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 5.7e-13, 39.83% id in 118 aa, and Staphylococcus carnosus hypothetical protein SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 1.4e-13, 40.67% id in 118 aa; hypothetical protein 2708981 2858913 SAR2624 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041969.1 2708550 D 282458 CDS YP_041970.1 49484746 2861328 complement(2709121..2710401) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase MvaA TR:Q9FD86 (EMBL:AF290086) (425 aa) fasta scores: E(): 1.2e-148, 97.64% id in 425 aa. Similar to Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-coenzyme A reductase MvaA SW:MVAA_PSEMV (P13702) (428 aa) fasta scores: E(): 3.2e-51, 40.41% id in 433 aa; 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2710401 mvaA 2861328 mvaA Staphylococcus aureus subsp. aureus MRSA252 3-hydroxy-3-methylglutaryl-coenzyme A reductase YP_041970.1 2709121 R 282458 CDS YP_041971.1 49484747 2861332 2710656..2711822 1 NC_002952.2 Previously sequenced as Staphylococcus aureus 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase MvaS TR:Q9FD87 (EMBL:AF290086) (388 aa) fasta scores: E(): 5.2e-149, 98.45% id in 388 aa. Similar to Staphylococcus haemolyticus HMG-CoA synthase MvaS TR:Q9FD82 (EMBL:AF290088) (388 aa) fasta scores: E(): 6.5e-127, 81.95% id in 388 aa; 3-hydroxy-3-methylglutaryl coenzyme A synthase 2711822 mvaS 2861332 mvaS Staphylococcus aureus subsp. aureus MRSA252 3-hydroxy-3-methylglutaryl coenzyme A synthase YP_041971.1 2710656 D 282458 CDS YP_041972.1 49484748 2858914 complement(2711993..2712514) 1 NC_002952.2 Similar to Bacillus subtilis methylated-DNA--protein-cysteine methyltransferase Ogt SW:OGT_BACSU (P11742) (165 aa) fasta scores: E(): 6.2e-14, 36.99% id in 173 aa, and to Haemophilus influenzae methylated-DNA--protein-cysteine methyltransferase HI0402 SW:OGT_HAEIN (P44687) (190 aa) fasta scores: E(): 9.7e-25, 45.19% id in 177 aa; 6-O-methylguanine DNA methyltransferase 2712514 2858914 SAR2627 Staphylococcus aureus subsp. aureus MRSA252 6-O-methylguanine DNA methyltransferase YP_041972.1 2711993 R 282458 CDS YP_041973.1 49484749 2859235 2712877..2714982 1 NC_002952.2 Similar to Lactococcus lactis ATP-dependent protease ATP-binding subunit ClpL SW:CLPL_LACLA (Q06716) (763 aa) fasta scores: E(): 3.3e-125, 54.81% id in 706 aa, and to Streptococcus pyogenes ATP-dependent Clp proteinase SPY0888 TR:Q9A086 (EMBL:AE006538) (699 aa) fasta scores: E(): 1.4e-144, 63.15% id in 692 aa. CDS contains fewer amino acids at the N-terminus in comparison to the Lactococcus lactis orthologue; ATP-dependent protease ATP-binding subunit ClpL 2714982 clpL 2859235 clpL Staphylococcus aureus subsp. aureus MRSA252 ATP-dependent protease ATP-binding subunit ClpL YP_041973.1 2712877 D 282458 CDS YP_041974.1 49484750 2858915 complement(2715052..2715222) 1 NC_002952.2 hypothetical protein 2715222 2858915 SAR2629 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041974.1 2715052 R 282458 CDS YP_041975.1 49484751 2858916 complement(2715235..2717229) 1 NC_002952.2 Similar to Escherichia coli ferrous iron transport protein B FeoB SW:FEOB_ECOLI (P33650) (773 aa) fasta scores: E(): 4.1e-69, 34.81% id in 718 aa, and to Methanococcus jannaschii ferrous iron transport protein B homologue MJ0566 SW:FEOB_METJA (Q57986) (668 aa) fasta scores: E(): 7.5e-89, 40.05% id in 679 aa; ferrous iron transport protein B 2717229 2858916 SAR2630 Staphylococcus aureus subsp. aureus MRSA252 ferrous iron transport protein B YP_041975.1 2715235 R 282458 CDS YP_041976.1 49484752 2858917 complement(2717241..2717468) 1 NC_002952.2 hypothetical protein 2717468 2858917 SAR2631 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041976.1 2717241 R 282458 CDS YP_041977.1 49484753 2858918 complement(2717683..2720172) 1 NC_002952.2 Similar to Bacillus subtilis YdfJ TR:P96687 (EMBL:AB001488) (724 aa) fasta scores: E(): 6.9e-108, 45.46% id in 717 aa, and to Streptomyces coelicolor integral membrane protein SC8G12.12 TR:Q9KYZ3 (EMBL:AL355753) (739 aa) fasta scores: E(): 2.9e-88, 39.2% id in 727 aa; transport protein 2720172 2858918 SAR2632 Staphylococcus aureus subsp. aureus MRSA252 transport protein YP_041977.1 2717683 R 282458 CDS YP_041978.1 49484754 2858919 2720317..2720865 1 NC_002952.2 Similar to Streptococcus pyogenes transcriptional regulator SPY1258 TR:Q99ZE9 (EMBL:AE006565) (180 aa) fasta scores: E(): 7.2e-06, 25.69% id in 179 aa, and to Lactococcus lactis transcriptional regulator YxcB TR:Q9CDI1 (EMBL:AE006453) (204 aa) fasta scores: E(): 2.5e-05, 23.4% id in 188 aa; TetR family regulatory protein 2720865 2858919 SAR2633 Staphylococcus aureus subsp. aureus MRSA252 TetR family regulatory protein YP_041978.1 2720317 D 282458 CDS YP_041979.1 49484755 2858920 complement(2721221..2722765) 1 NC_002952.2 catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate; 1-pyrroline-5-carboxylate dehydrogenase 2722765 2858920 SAR2634 Staphylococcus aureus subsp. aureus MRSA252 1-pyrroline-5-carboxylate dehydrogenase YP_041979.1 2721221 R 282458 CDS YP_041980.1 49484756 2858921 complement(2722955..2723554) 1 NC_002952.2 Similar to Escherichia coli galactoside O-acetyltransferase LacA SW:THGA_ECOLI (P07464) (203 aa) fasta scores: E(): 9.1e-28, 43.01% id in 186 aa, and to Streptococcus pyogenes acetyltransferase SPY1065 TR:Q99ZU6 (EMBL:AE006551) (188 aa) fasta scores: E(): 1.5e-42, 56.45% id in 186 aa; acetyltransferase 2723554 2858921 SAR2635 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase YP_041980.1 2722955 R 282458 CDS YP_041981.1 49484757 2858922 2723784..2723984 1 NC_002952.2 Poor database matches. Similar to the N-terminal regions of Streptomyces coelicolor hypothetical protein SCP8.13 TR:Q9FBK8 (EMBL:AL390975) (161 aa) fasta scores: E(): 8.9, 31.74% id in 63 aa; hypothetical protein 2723984 2858922 SAR2636 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041981.1 2723784 D 282458 CDS YP_041982.1 49484758 2859243 2724224..2726632 1 NC_002952.2 Similar to Enterococcus hirae probable copper importing ATPase A CopA SW:COPA_ENTHR (P32113) (727 aa) fasta scores: E(): 9.8e-120, 50.34% id in 725 aa, and to Bacillus halodurans copper-transporting ATPase BH0557 TR:Q9KFC7 (EMBL:AP001508) (806 aa) fasta scores: E(): 5.6e-154, 55.15% id in 805 aa. CDS contains extra amino acids at the N-terminus in comparison to the Enterococcus hirae orthologue; copper importing ATPase A 2726632 copA 2859243 copA Staphylococcus aureus subsp. aureus MRSA252 copper importing ATPase A YP_041982.1 2724224 D 282458 CDS YP_041983.1 49484759 2858923 2727453..2727659 1 NC_002952.2 Similar to Enterococcus hirae activator of copYZAB CopZ SW:COPZ_ENTHR (Q47840) (69 aa) fasta scores: E(): 4.4e-05, 36.92% id in 65 aa, and to Bacillus subtilis hypothetical protein YvgY TR:O32221 (EMBL:Z99121) (69 aa) fasta scores: E(): 4.5e-12, 56.71% id in 67 aa; heavy-metal-associated protein 2727659 2858923 SAR2639 Staphylococcus aureus subsp. aureus MRSA252 heavy-metal-associated protein YP_041983.1 2727453 D 282458 CDS YP_041984.1 49484760 2858924 complement(2727749..2728747) 1 NC_002952.2 catalyzes the formation of pyruvate from lactate; D-lactate dehydrogenase 2728747 2858924 SAR2640 Staphylococcus aureus subsp. aureus MRSA252 D-lactate dehydrogenase YP_041984.1 2727749 R 282458 CDS YP_041985.1 49484761 2858925 complement(2728770..2729924) 1 NC_002952.2 Similar to Bacillus subtilis probable aspartate aminotransferase YwfG SW:AAT2_BACSU (P39643) (399 aa) fasta scores: E(): 5.2e-52, 39.52% id in 382 aa, and to Bacillus halodurans aspartate aminotransferase BH1060 TR:Q9KE01 (EMBL:AP001510) (395 aa) fasta scores: E(): 5.9e-52, 39.48% id in 385 aa; aminotransferase 2729924 2858925 SAR2641 Staphylococcus aureus subsp. aureus MRSA252 aminotransferase YP_041985.1 2728770 R 282458 CDS YP_041986.1 49484762 2859245 complement(2730351..2731859) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus squalene synthase CrtN TR:O07855 (EMBL:X73889) (506 aa) fasta scores: E(): 1.1e-184, 97% id in 500 aa. Similar to Erwinia herbicola phytoene dehydrogenase CrtI SW:CRTI_ERWHE (P22871) (492 aa) fasta scores: E(): 2.1e-47, 32.47% id in 502 aa; squalene synthase 2731859 crtN 2859245 crtN Staphylococcus aureus subsp. aureus MRSA252 squalene synthase YP_041986.1 2730351 R 282458 CDS YP_041987.1 49484763 2858926 complement(2732771..2733898) 1 NC_002952.2 Similar to Deinococcus radiodurans conserved hypothetical protein DR0089 TR:Q9RY61 (EMBL:AE001872) (358 aa) fasta scores: E(): 6.6e-09, 24.85% id in 334 aa, and to Pyrococcus abyssi hyaluronan synthase related protein PAB1314 TR:Q9UYC7 (EMBL:AJ248288) (350 aa) fasta scores: E(): 0.00076, 22.28% id in 332 aa; glycosyl transferase 2733898 2858926 SAR2645 Staphylococcus aureus subsp. aureus MRSA252 glycosyl transferase YP_041987.1 2732771 R 282458 CDS YP_041988.1 49484764 2858927 complement(2733904..2735397) 1 NC_002952.2 Similar to Myxococcus xanthus phytoene dehydrogenase CarA2 SW:CRTJ_MYXXA (P54979) (517 aa) fasta scores: E(): 2.8e-42, 29.96% id in 494 aa, and to Erwinia herbicola phytoene dehydrogenase CrtI SW:CRTI_ERWHE (P22871) (492 aa) fasta scores: E(): 5.3e-38, 27.55% id in 490 aa; phytoene dehydrogenase related protein 2735397 2858927 SAR2646 Staphylococcus aureus subsp. aureus MRSA252 phytoene dehydrogenase related protein YP_041988.1 2733904 R 282458 CDS YP_041989.1 49484765 2860560 complement(2735390..2735887) 1 NC_002952.2 Poor database matches. Weakly similar to Pyrococcus abyssi hypothetical protein PAB1170 TR:Q9UXS9 (EMBL:AJ248288) (220 aa) fasta scores: E(): 8.3, 24.34% id in 152 aa; hypothetical protein 2735887 2860560 SAR2647 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041989.1 2735390 R 282458 CDS YP_041990.1 49484766 2859504 complement(2736059..2736826) 1 NC_002952.2 Similar to Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 2.4e-65, 75.19% id in 258 aa, and to Staphylococcus carnosus SceB precursor SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 2.5e-54, 63.49% id in 263 aa. Similar to SAR2383, 75.093% identity (79.216% ungapped) in 269 aa overlap; secretory antigen precursor 2736826 ssaA 2859504 ssaA Staphylococcus aureus subsp. aureus MRSA252 secretory antigen precursor YP_041990.1 2736059 R 282458 CDS YP_041991.1 49484767 2860561 complement(2737187..2738998) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YrhL TR:O05402 (EMBL:U93874) (634 aa) fasta scores: E(): 6.9e-54, 38.86% id in 633 aa, and to Lactococcus lactis hypothetical protein YvhB TR:Q9CDV4 (EMBL:AE006439) (605 aa) fasta scores: E(): 6.5e-42, 31.78% id in 604 aa. Similar to SAR0937, 57.475% identity (58.545% ungapped) in 602 aa overlap; hypothetical protein 2738998 2860561 SAR2649 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041991.1 2737187 R 282458 CDS YP_041992.1 49484768 2859671 complement(2739685..2740386) 1 NC_002952.2 Similar to Staphylococcus aureus immunodominant antigen A IsaA TR:Q9LAB6 (EMBL:AF144681) (233 aa) fasta scores: E(): 4.7e-78, 99.57% id in 233 aa, and to Staphylococcus carnosus SceA precursor SceA TR:O54494 (EMBL:AF109218) (237 aa) fasta scores: E(): 2.5e-14, 34.8% id in 227 aa; immunodominant antigen A 2740386 isaA 2859671 isaA Staphylococcus aureus subsp. aureus MRSA252 immunodominant antigen A YP_041992.1 2739685 R 282458 CDS YP_041993.1 49484769 2860562 complement(2740994..2742049) 1 NC_002952.2 Similar to Treponema pallidum regulatory protein TP0038 TR:Q56343 (EMBL:AE001189) (350 aa) fasta scores: E(): 1.4e-52, 44.89% id in 343 aa, and to Streptococcus pyogenes probable regulatory protein SPY0851 TR:Q9A0B4 (EMBL:AE006535) (352 aa) fasta scores: E(): 4.9e-45, 42.61% id in 359 aa; hypothetical protein 2742049 2860562 SAR2651 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041993.1 2740994 R 282458 CDS YP_041994.1 49484770 2860563 2742460..2743029 1 NC_002952.2 Similar to Lactococcus lactis transcriptional regulator YxcB TR:Q9CDI1 (EMBL:AE006453) (204 aa) fasta scores: E(): 2.3e-09, 29.5% id in 183 aa, and to Bacillus subtilis hypothetical protein YxbF SW:YXBF_BACSU (P46330) (380 aa) fasta scores: E(): 5.2e-06, 30.6% id in 183 aa; TetR family regulatory protein 2743029 2860563 SAR2652 Staphylococcus aureus subsp. aureus MRSA252 TetR family regulatory protein YP_041994.1 2742460 D 282458 CDS YP_041995.1 49484771 2860564 2743227..2743727 1 NC_002952.2 No significant database matches. Possible alternative translational start sites; hypothetical protein 2743727 2860564 SAR2653 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041995.1 2743227 D 282458 CDS YP_041996.1 49484772 2860565 2743947..2744177 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YnzC TR:O31818 (EMBL:Z99113) (77 aa) fasta scores: E(): 7.1e-07, 49.15% id in 59 aa, and to Lactococcus lactis hypothetical protein YlaC TR:Q9CGJ9 (EMBL:AE006342) (80 aa) fasta scores: E(): 2.3e-06, 42.85% id in 70 aa; hypothetical protein 2744177 2860565 SAR2654 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041996.1 2743947 D 282458 CDS YP_041997.1 49484773 2860566 complement(2744340..2744717) 1 NC_002952.2 Similar to Escherichia coli, and lactoylglutathione lyase GloA SW:LGUL_ECOLI (Q59384) (135 aa) fasta scores: E(): 0.52, 27.86% id in 122 aa, and to Bacillus halodurans hypothetical protein BH3119 TR:Q9K887 (EMBL:AP001517) (134 aa) fasta scores: E(): 1.6e-07, 33.6% id in 125 aa; glyoxalase 2744717 2860566 SAR2655 Staphylococcus aureus subsp. aureus MRSA252 glyoxalase YP_041997.1 2744340 R 282458 CDS YP_041998.1 49484774 2860567 complement(2744734..2745555) 1 NC_002952.2 Similar to Streptomyces coelicolor actinorhodin biosynthetic protein ActVA 4 TR:Q53906 (EMBL:X58833) (294 aa) fasta scores: E(): 4.6e-20, 34.15% id in 284 aa, and to Rhizobium loti hypothetical protein MLL7605 protein mll7605 TR:BAB54033 (EMBL:AP003012) (294 aa) fasta scores: E(): 9.6e-12, 25.79% id in 283 aa; hypothetical protein 2745555 2860567 SAR2656 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041998.1 2744734 R 282458 CDS YP_041999.1 49484775 2860568 complement(2745574..2745873) 1 NC_002952.2 Poor database matches. Similar to the C-terminal region of Deinococcus radiodurans hypothetical protein DR1049 TR:Q9RVI0 (EMBL:AE001956) (124 aa) fasta scores: E(): 1.7, 32% id in 100 aa; hypothetical protein 2745873 2860568 SAR2657 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_041999.1 2745574 R 282458 CDS YP_042000.1 49484776 2860569 2746004..2746561 1 NC_002952.2 No significant database matches to the full length CDS. Similar to Bacillus halodurans transcriptional regulator BH2145 TR:Q9KAZ1 (EMBL:AP001514) (193 aa) fasta scores: E(): 0.00041, 30.76% id in 130 aa, and to Mycobacterium tuberculosis transcriptional regulator MTV030.10c TR:O53612 (EMBL:AL021428) (189 aa) fasta scores: E(): 0.0013, 28.7% id in 108 aa; TetR family regulatory protein 2746561 2860569 SAR2658 Staphylococcus aureus subsp. aureus MRSA252 TetR family regulatory protein YP_042000.1 2746004 D 282458 CDS YP_042001.1 49484777 2860570 2746554..2747258 1 NC_002952.2 Similar to Rhizobium meliloti acetoacetyl-CoA reductase PhbB SW:PHBB_RHIME (P50205) (241 aa) fasta scores: E(): 8.8e-10, 29.71% id in 249 aa, and to Streptomyces coelicolor short chain oxidoreductase SCM1.23c TR:Q9RD20 (EMBL:AL133422) (235 aa) fasta scores: E(): 1.1e-31, 44.87% id in 234 aa; short chain dehydrogenase 2747258 2860570 SAR2659 Staphylococcus aureus subsp. aureus MRSA252 short chain dehydrogenase YP_042001.1 2746554 D 282458 CDS YP_042002.1 49484778 2860571 2747356..2748366 1 NC_002952.2 Similar to Synechocystis sp hypothetical protein SLR0619 TR:Q55861 (EMBL:D64004) (348 aa) fasta scores: E(): 1.1e-31, 35.34% id in 348 aa. Weakly similar to Rhizobium loti hypothetical protein MLR9221 TR:BAB54605 (EMBL:AP003015) (357 aa) fasta scores: E(): 0.0003, 20.51% id in 312 aa; hypothetical protein 2748366 2860571 SAR2660 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042002.1 2747356 D 282458 CDS YP_042003.1 49484779 2860572 2748386..2749216 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YraK TR:O07937 (EMBL:X92868) (229 aa) fasta scores: E(): 3.7e-09, 28.21% id in 241 aa, and to Streptomyces rishiriensis hydrolase CouN7 TR:Q9F8U0 (EMBL:AF235050) (281 aa) fasta scores: E(): 2.8e-08, 26.25% id in 278 aa; hydrolase 2749216 2860572 SAR2661 Staphylococcus aureus subsp. aureus MRSA252 hydrolase YP_042003.1 2748386 D 282458 CDS YP_042004.1 49484780 2860573 complement(2749363..2750253) 1 NC_002952.2 Similar to Bacillus halodurans BH0366 TR:Q9KFV5 (EMBL:AP001508) (311 aa) fasta scores: E(): 2e-23, 29.77% id in 309 aa, and to Deinococcus radiodurans CobW protein DR2408 TR:Q9RRS7 (EMBL:AE002071) (320 aa) fasta scores: E(): 1.9e-18, 28.28% id in 304 aa; cobalamin synthesis protein/P47K family protein 2750253 2860573 SAR2662 Staphylococcus aureus subsp. aureus MRSA252 cobalamin synthesis protein/P47K family protein YP_042004.1 2749363 R 282458 CDS YP_042005.1 49484781 2860574 complement(2750353..2751699) 1 NC_002952.2 No significant database matches to the full length CDS. C-terminus is weakly similar to the C-terminal region of Archaeoglobus fulgidus iron (II) transporter (FeoB-1) AF0246 TR:O29993 (EMBL:AE001089) (639 aa) fasta scores: E(): 4.1e-11, 19.89% id in 372 aa. Internal region is weakly similar to an internal region of Escherichia coli ferrous iron transport protein B FeoB SW:FEOB_ECOLI (P33650) (773 aa) fasta scores: E(): 2e-07, 20.71% id in 280 aa; hypothetical protein 2751699 2860574 SAR2663 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042005.1 2750353 R 282458 CDS YP_042006.1 49484782 2860575 complement(2751687..2752793) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YpdA SW:YPDA_BACSU (P50736) (324 aa) fasta scores: E(): 7.2e-08, 25.56% id in 352 aa. N-terminus is similar to the N-terminal region of Onchocerca volvulus glutathione reductase TR:O01412 (EMBL:Y11830) (462 aa) fasta scores: E(): 0.32, 23.38% id in 201 aa; hypothetical protein 2752793 2860575 SAR2664 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042006.1 2751687 R 282458 CDS YP_042007.1 49484783 2860576 complement(2753126..2753422) 1 NC_002952.2 Similar to Bacillus halodurans BH0980 TR:Q9KE76 (EMBL:AP001510) (102 aa) fasta scores: E(): 4.7e-18, 56.25% id in 96 aa, and to Bacillus pseudofirmus hypothetical protein TR:O50571 (EMBL:U89914) (93 aa) fasta scores: E(): 0.038, 32.43% id in 74 aa; hypothetical protein 2753422 2860576 SAR2665 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042007.1 2753126 R 282458 CDS YP_042008.1 49484784 2860577 complement(2753410..2753778) 1 NC_002952.2 hypothetical protein 2753778 2860577 SAR2666 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042008.1 2753410 R 282458 CDS YP_042009.1 49484785 2860578 complement(2753793..2754071) 1 NC_002952.2 hypothetical protein 2754071 2860578 SAR2667 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042009.1 2753793 R 282458 CDS YP_042010.1 49484786 2860579 complement(2754408..2755274) 1 NC_002952.2 Similar to Mus musculus fructosamine-3-kinase FN3K SW:FN3K_MOUSE (Q9ER35) (309 aa) fasta scores: E(): 8.9e-18, 30% id in 310 aa, and to Vibrio cholerae hypothetical protein VC1539 SW:YF39_VIBCH (Q9KRU5) (288 aa) fasta scores: E(): 9.7e-24, 32.63% id in 288 aa; hypothetical protein 2755274 2860579 SAR2668 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042010.1 2754408 R 282458 CDS YP_042011.1 49484787 2860580 2755492..2756556 1 NC_002952.2 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 2756556 2860580 SAR2669 Staphylococcus aureus subsp. aureus MRSA252 dihydroorotate dehydrogenase 2 YP_042011.1 2755492 D 282458 CDS YP_042012.1 49484788 2860581 2756711..2756986 1 NC_002952.2 hypothetical protein 2756986 2860581 SAR2670 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042012.1 2756711 D 282458 CDS YP_042013.1 49484789 2860582 complement(2757172..2757894) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YoaD TR:Q9CFU8 (EMBL:AE006369) (241 aa) fasta scores: E(): 4.7e-67, 67.79% id in 236 aa, and to Streptococcus pyogenes hypothetical protein SPY0233 TR:Q9A1K3 (EMBL:AE006490) (255 aa) fasta scores: E(): 2.2e-59, 59.74% id in 236 aa; hypothetical protein 2757894 2860582 SAR2671 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042013.1 2757172 R 282458 CDS YP_042014.1 49484790 2860583 2758250..2758699 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YldC TR:Q9CGH3 (EMBL:AE006345) (152 aa) fasta scores: E(): 1.2e-26, 44.96% id in 149 aa, and to Pseudomonas aeruginosa hypothetical protein PA1353 TR:Q9I3Z1 (EMBL:AE004565) (137 aa) fasta scores: E(): 1.5e-05, 26.61% id in 139 aa; hypothetical protein 2758699 2860583 SAR2672 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042014.1 2758250 D 282458 CDS YP_042015.1 49484791 2860584 complement(2758780..2759367) 1 NC_002952.2 Similar to Clostridium acetobutylicum TetR family transcriptional regulator CAP0046 TR:Q97TQ2 (EMBL:AE001438) (188 aa) fasta scores: E(): 4e-10, 26.82% id in 164 aa, and to Lactococcus lactis transcriptional regulator YxcB TR:Q9CDI1 (EMBL:AE006453) (204 aa) fasta scores: E(): 2e-09, 23.46% id in 196 aa; DNA-binding protein 2759367 2860584 SAR2673 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_042015.1 2758780 R 282458 CDS YP_042016.1 49484792 2860585 2759510..2761192 1 NC_002952.2 SLactococcus lactis hypothetical protein YmgC TR:Q9CG75 (EMBL:AE006355) (572 aa) fasta scores: E(): 6.6e-53, 32.67% id in 554 aa. Weakly similar to Rhodococcus sp MB1 cocaine esterase CocE TR:Q9L9D7 (EMBL:AF173165) (574 aa) fasta scores: E(): 8.1e-06, 25.12% id in 613 aa; hypothetical protein 2761192 2860585 SAR2674 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042016.1 2759510 D 282458 CDS YP_042017.1 49484793 2861474 complement(2761321..2761704) 1 NC_002952.2 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 2761704 panD 2861474 panD Staphylococcus aureus subsp. aureus MRSA252 aspartate alpha-decarboxylase YP_042017.1 2761321 R 282458 CDS YP_042018.1 49484794 2861473 complement(2761706..2762557) 1 NC_002952.2 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 2762557 panC 2861473 panC Staphylococcus aureus subsp. aureus MRSA252 pantoate--beta-alanine ligase YP_042018.1 2761706 R 282458 CDS YP_042019.1 49484795 2861472 complement(2762550..2763368) 1 NC_002952.2 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 2763368 panB 2861472 panB Staphylococcus aureus subsp. aureus MRSA252 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_042019.1 2762550 R 282458 CDS YP_042020.1 49484796 2860586 2763441..2764301 1 NC_002952.2 catalyzes the formation of 2-dehydropantoate from (R)-pantoate; 2-dehydropantoate 2-reductase 2764301 2860586 SAR2678 Staphylococcus aureus subsp. aureus MRSA252 2-dehydropantoate 2-reductase YP_042020.1 2763441 D 282458 CDS YP_042021.1 49484797 2860587 complement(2764387..2765091) 1 NC_002952.2 Similar to Klebsiella terrigena alpha-acetolactate decarboxylase BudA SW:ALDC_KLETE (Q04518) (259 aa) fasta scores: E(): 1.2e-23, 33.47% id in 236 aa, and to Lactococcus lactis alpha-acetolactate decarboxylase AldB TR:P95676 (EMBL:S82499) (236 aa) fasta scores: E(): 5.2e-36, 44.72% id in 237 aa. CDS is truncated at the N-terminus in comparison to the Klebsiella terrigena protein. Similar to SAR2296, 74.359% identity (74.359% ungapped) in 234 aa overlap; alpha-acetolactate decarboxylase 2765091 2860587 SAR2679 Staphylococcus aureus subsp. aureus MRSA252 alpha-acetolactate decarboxylase YP_042021.1 2764387 R 282458 CDS YP_042022.1 49484798 2859696 complement(2765369..2766328) 1 NC_002952.2 Similar to Bacillus caldotenax L-lactate dehydrogenase Ldh SW:LDH_BACCA (P10655) (317 aa) fasta scores: E(): 2.7e-60, 54.75% id in 305 aa, and to Bacillus caldolyticus L-lactate dehydrogenase TR:Q59244 (EMBL:M19394) (317 aa) fasta scores: E(): 2.3e-60, 54.87% id in 308 aa. Similar to SAR0234, 59.223% identity (59.609% ungapped) in 309 aa overlap; L-lactate dehydrogenase 2 2766328 ldh2 2859696 ldh2 Staphylococcus aureus subsp. aureus MRSA252 L-lactate dehydrogenase 2 YP_042022.1 2765369 R 282458 CDS YP_042023.1 49484799 2860588 2767014..2768462 1 NC_002952.2 Similar to Lactococcus lactis cationic amino acid transporter CtrA TR:Q9CJ89 (EMBL:AE006249) (469 aa) fasta scores: E(): 1.9e-111, 64.51% id in 465 aa, and to Xylella fastidiosa cationic amino acid transporter XF2207 TR:Q9PBD7 (EMBL:AE004033) (483 aa) fasta scores: E(): 3.1e-51, 35.72% id in 459 aa; amino acid permease 2768462 2860588 SAR2681 Staphylococcus aureus subsp. aureus MRSA252 amino acid permease YP_042023.1 2767014 D 282458 CDS YP_042024.1 49484800 2860589 complement(2768542..2769885) 1 NC_002952.2 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2769885 2860589 SAR2682 Staphylococcus aureus subsp. aureus MRSA252 4-aminobutyrate aminotransferase YP_042024.1 2768542 R 282458 CDS YP_042025.1 49484801 2860590 2770133..2770549 1 NC_002952.2 hypothetical protein 2770549 2860590 SAR2683 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042025.1 2770133 D 282458 CDS YP_042026.1 49484802 2860659 2770672..2771562 1 NC_002952.2 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis; fructose-1,6-bisphosphate aldolase 2771562 fda 2860659 fda Staphylococcus aureus subsp. aureus MRSA252 fructose-1,6-bisphosphate aldolase YP_042026.1 2770672 D 282458 CDS YP_042027.1 49484803 2861308 complement(2771755..2773251) 1 NC_002952.2 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2773251 mqo2 2861308 mqo2 Staphylococcus aureus subsp. aureus MRSA252 malate:quinone oxidoreductase YP_042027.1 2771755 R 282458 CDS YP_042028.1 49484804 2860591 2773678..2773878 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 2773878 2860591 SAR2686 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042028.1 2773678 D 282458 CDS YP_042029.1 49484805 2860592 complement(2773938..2775557) 1 NC_002952.2 Similar to Homo sapiens hypothetical protein associated with susceptibility to essential hypertension, SA TR:Q13732 (EMBL:D16350) (578 aa) fasta scores: E(): 3.6e-69, 37.68% id in 544 aa, and to Bacillus subtilis hypothetical protein YtcI TR:O34613 (EMBL:AF008220) (531 aa) fasta scores: E(): 1.8e-122, 57.17% id in 530 aa. CDS is truncated at the N-terminus in comparison to the Homo sapiens protein; AMP-binding protein 2775557 2860592 SAR2687 Staphylococcus aureus subsp. aureus MRSA252 AMP-binding protein YP_042029.1 2773938 R 282458 CDS YP_042030.1 49484806 2860593 complement(2775730..2776173) 1 NC_002952.2 Poor database matches. Similar to the C-terminal region of Bacillus subtilis hypothetical protein YhgC SW:YHGC_BACSU (P38049) (166 aa) fasta scores: E(): 2.7e-11, 35.53% id in 121 aa; hypothetical protein 2776173 2860593 SAR2688 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042030.1 2775730 R 282458 CDS YP_042031.1 49484807 2860594 complement(2776453..2776665) 1 NC_002952.2 Poor database matches. Weakly similar to Bacillus subtilis hypothetical protein YozE TR:O31864 (EMBL:Z99114) (74 aa) fasta scores: E(): 7.9, 28.16% id in 71 aa; hypothetical protein 2776665 2860594 SAR2689 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042031.1 2776453 R 282458 CDS YP_042032.1 49484808 2859253 complement(2776943..2778652) 1 NC_002952.2 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 2778652 cudB 2859253 cudB Staphylococcus aureus subsp. aureus MRSA252 choline dehydrogenase YP_042032.1 2776943 R 282458 CDS YP_042033.1 49484809 2859252 complement(2778913..2780403) 1 NC_002952.2 Similar to Staphylococcus xylosus glycine betaine aldehyde dehydrogenase CudA TR:Q9X2M1 (EMBL:AF009415) (497 aa) fasta scores: E(): 3.2e-161, 82.05% id in 496 aa, and to Bacillus subtilis betaine aldehyde dehydrogenase GbsA SW:DHAB_BACSU (P71016) (490 aa) fasta scores: E(): 2.2e-129, 66.87% id in 489 aa; betaine aldehyde dehydrogenase 2780403 cudA 2859252 cudA Staphylococcus aureus subsp. aureus MRSA252 betaine aldehyde dehydrogenase YP_042033.1 2778913 R 282458 CDS YP_042034.1 49484810 2860595 2780653..2781219 1 NC_002952.2 Similar to Staphylococcus xylosus regulatory protein CudC TR:Q9X2M0 (EMBL:AF009415) (186 aa) fasta scores: E(): 1.2e-45, 70.33% id in 182 aa, and to Bacillus subtilis hypothetical protein YuaC SW:YUAC_BACSU (P71015) (180 aa) fasta scores: E(): 6.5e-33, 55.35% id in 168 aa; hypothetical protein 2781219 2860595 SAR2692 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042034.1 2780653 D 282458 CDS YP_042035.1 49484811 2859254 complement(2781389..2783011) 1 NC_002952.2 Similar to Staphylococcus xylosus choline transporter CudT TR:Q9X2L9 (EMBL:AF009415) (540 aa) fasta scores: E(): 2.8e-171, 77.4% id in 540 aa, and to Corynebacterium glutamicum glycine betaine transporter BetP SW:BETP_CORGL (P54582) (595 aa) fasta scores: E(): 9e-49, 30.63% id in 519 aa. CDS is truncated at the N-terminus in comparison to the Corynebacterium glutamicum protein; choline transporter 2783011 cudT 2859254 cudT Staphylococcus aureus subsp. aureus MRSA252 choline transporter YP_042035.1 2781389 R 282458 CDS YP_042036.1 49484812 2859167 complement(2783529..2784065) 1 NC_002952.2 Similar to Escherichia coli anaerobic ribonucleoside-triphosphate reductase activating protein NrdG SW:NRDG_ECOLI (P39329) (154 aa) fasta scores: E(): 4.7e-15, 38.46% id in 143 aa, and to Lactococcus lactis anaerobic ribonucleotide reductase activator protein NrdG TR:Q9ZAX5 (EMBL:U73336) (199 aa) fasta scores: E(): 2.9e-26, 46.98% id in 166 aa; anaerobic ribonucleotide reductase activating protein 2784065 nrdG 2859167 nrdG Staphylococcus aureus subsp. aureus MRSA252 anaerobic ribonucleotide reductase activating protein YP_042036.1 2783529 R 282458 CDS YP_042037.1 49484813 2859166 complement(2784062..2785912) 1 NC_002952.2 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 2785912 nrdD 2859166 nrdD Staphylococcus aureus subsp. aureus MRSA252 anaerobic ribonucleoside triphosphate reductase YP_042037.1 2784062 R 282458 CDS YP_042038.1 49484814 2860596 complement(2786159..2787529) 1 NC_002952.2 Similar to Bacillus subtilis citrate transporter CitN SW:CITN_BACSU (P42308) (426 aa) fasta scores: E(): 5.1e-21, 32.81% id in 448 aa, and to Bacillus halodurans magnesium citrate secondary transporter BH0745 TR:Q9KEV4 (EMBL:AP001509) (442 aa) fasta scores: E(): 2e-83, 50.55% id in 449 aa; transporter protein 2787529 2860596 SAR2696 Staphylococcus aureus subsp. aureus MRSA252 transporter protein YP_042038.1 2786159 R 282458 CDS YP_042039.1 49484815 2860597 complement(2788018..2788626) 1 NC_002952.2 catalyzes the formation of siroheme from precorrin-2; precorrin-2 dehydrogenase 2788626 2860597 SAR2697 Staphylococcus aureus subsp. aureus MRSA252 precorrin-2 dehydrogenase YP_042039.1 2788018 R 282458 CDS YP_042040.1 49484816 2859257 complement(2788692..2790572) 1 NC_002952.2 C-terminus is similar to the C-terminal region of Escherichia coli sulfite reductase [NADPH] flavoprotein alpha-component CysJ SW:CYSJ_ECOLI (P38038) (598 aa) fasta scores: E(): 3.3e-75, 39.41% id in 548 aa. Similar to the full length Bacillus subtilis sulfite reductase [NADPH] flavoprotein alpha-component-like protein YvgR TR:O32214 (EMBL:Z99121) (605 aa) fasta scores: E(): 6.8e-110, 48.08% id in 628 aa; sulfite reductase [NADPH] flavoprotein alpha-component 2790572 cysJ 2859257 cysJ Staphylococcus aureus subsp. aureus MRSA252 sulfite reductase [NADPH] flavoprotein alpha-component YP_042040.1 2788692 R 282458 CDS YP_042041.1 49484817 2860598 complement(2790963..2791460) 1 NC_002952.2 Similar to Citrus sinensis glutathione peroxidase homologue CSA SW:GSHZ_CITSI (Q06652) (167 aa) fasta scores: E(): 2.7e-25, 41.13% id in 158 aa, and to Schizosaccharomyces pombe glutathione peroxidase GPX1 SW:GSHJ_SCHPO (O59858) (158 aa) fasta scores: E(): 6.6e-27, 46.1% id in 154 aa. Similar to SAR1280, 50.323% identity (50.323% ungapped) in 155 aa overlap; glutathione peroxidase 2791460 2860598 SAR2699 Staphylococcus aureus subsp. aureus MRSA252 glutathione peroxidase YP_042041.1 2790963 R 282458 CDS YP_042042.1 49484818 2860599 complement(2792901..2794901) 1 NC_002952.2 Similar to Lactococcus lactis ABC transporter permease and substrate binding protein YsaB TR:Q9CET5 (EMBL:AE006405) (667 aa) fasta scores: E(): 2.2e-23, 22.79% id in 693 aa, and to Bacillus halodurans ABC transporter BH0752 TR:Q9KEU7 (EMBL:AP001509) (642 aa) fasta scores: E(): 5.5e-10, 21.57% id in 672 aa; hypothetical protein 2794901 2860599 SAR2700 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042042.1 2792901 R 282458 CDS YP_042043.1 49484819 2860600 complement(2794898..2795653) 1 NC_002952.2 Similar to Lactococcus lactis ABC transporter ATP-binding protein YsaC TR:Q9CET4 (EMBL:AE006405) (259 aa) fasta scores: E(): 7e-38, 48% id in 250 aa, and to Bacillus subtilis hypothetical ABC transporter ATP-binding protein YxdL SW:YXDL_BACSU (P42423) (257 aa) fasta scores: E(): 3.9e-37, 49.2% id in 250 aa; ABC transporter ATP-binding protein 2795653 2860600 SAR2701 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_042043.1 2794898 R 282458 CDS YP_042044.1 49484820 2860601 complement(2795761..2796648) 1 NC_002952.2 Two-component regulatory system family, sensor kinase. Similar to Streptococcus pneumoniae histidine kinase SP1632 TR:Q9S1K1 (EMBL:AJ006391) (324 aa) fasta scores: E(): 7e-27, 32.77% id in 299 aa, and to Lactococcus lactis sensor protein kinase KinG TR:Q9CET8 (EMBL:AE006404) (291 aa) fasta scores: E(): 1.3e-24, 31.61% id in 291 aa; sensor kinase 2796648 2860601 SAR2702 Staphylococcus aureus subsp. aureus MRSA252 sensor kinase YP_042044.1 2795761 R 282458 CDS YP_042045.1 49484821 2860602 complement(2796659..2797324) 1 NC_002952.2 Two-component regulatory system family, response regulator protein. Similar to Streptococcus thermophilus response regulator Rr1 TR:Q9AGS2 (EMBL:AF327738) (226 aa) fasta scores: E(): 2.5e-42, 51.83% id in 218 aa, and to Streptococcus pneumoniae response regulator SP1633 TR:Q9S1K2 (EMBL:AJ006391) (225 aa) fasta scores: E(): 1.6e-39, 48.62% id in 218 aa; response regulator protein 2797324 2860602 SAR2703 Staphylococcus aureus subsp. aureus MRSA252 response regulator protein YP_042045.1 2796659 R 282458 CDS YP_042046.1 49484822 2860603 complement(2797350..2797550) 1 NC_002952.2 hypothetical protein 2797550 2860603 SAR2704 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042046.1 2797350 R 282458 CDS YP_042047.1 49484823 2860732 2797873..2798820 1 NC_002952.2 Identical to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 2.8e-127, 100.000% id in 315 aa, and similar to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 3e-71, 58.413% id in 315 aa; transposase 2798820 2860732 SAR2705 Staphylococcus aureus subsp. aureus MRSA252 transposase YP_042047.1 2797873 D 282458 CDS YP_042048.1 49484824 2860733 complement(2800306..2800407) 1 NC_002952.2 Doubtful CDS; hypothetical protein 2800407 2860733 SAR2706a Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042048.1 2800306 R 282458 CDS YP_042049.1 49484825 2860734 complement(2800529..2800984) 1 NC_002952.2 Similar to Lactococcus lactis transcriptional regulator RmaF TR:Q9CG06 (EMBL:AE006362) (156 aa) fasta scores: E(): 1.7e-13, 37.68% id in 138 aa. Weakly similar to Escherichia coli haemolysin transcriptional regulator SlyA SW:SLYA_ECOLI (P55740) (146 aa) fasta scores: E(): 0.33, 26.61% id in 124 aa; regulatory protein 2800984 2860734 SAR2707 Staphylococcus aureus subsp. aureus MRSA252 regulatory protein YP_042049.1 2800529 R 282458 CDS YP_042050.1 49484826 2860735 complement(2801229..2801990) 1 NC_002952.2 Similar to Lactococcus lactis tributyrin esterase EstA TR:Q9L9W2 (EMBL:AF157601) (258 aa) fasta scores: E(): 1.1e-27, 36.36% id in 253 aa, and to Streptococcus pyogenes tributyrin esterase SPY1022 TR:Q99ZY1 (EMBL:AE006547) (261 aa) fasta scores: E(): 1.7e-22, 30.58% id in 255 aa; esterase 2801990 2860735 SAR2708 Staphylococcus aureus subsp. aureus MRSA252 esterase YP_042050.1 2801229 R 282458 CDS YP_042051.1 49484827 2859232 complement(2802106..2804727) 1 NC_002952.2 Similar to Staphylococcus aureus clumping factor B precursor ClfB TR:O86476 (EMBL:AJ224764) (913 aa) fasta scores: E(): 4.6e-184, 89.48% id in 913 aa, and to Staphylococcus epidermidis fibrinogen-binding protein precursor TR:O70022 (EMBL:Y17116) (1092 aa) fasta scores: E(): 4.8e-44, 36.53% id in 1103 aa. CDS contains imperfect dipetide repeat (DS x321) between residues 587 and 800. In comparison to the ClfB protein, the CDS contains extra copies of the DS repeat. Probable LPXTG-sorted surface protein; fibrinogen and keratin-10 binding surface anchored protein 2804727 clfB 2859232 clfB Staphylococcus aureus subsp. aureus MRSA252 fibrinogen and keratin-10 binding surface anchored protein YP_042051.1 2802106 R 282458 CDS YP_042052.1 49484828 2860736 complement(2805077..2805781) 1 NC_002952.2 Similar to Anabaena sp global nitrogen regulator NtcA SW:NTCA_ANASP (Q05061) (223 aa) fasta scores: E(): 0.0051, 18.94% id in 190 aa, and to Bacillus licheniformis Crp/Fnr family protein ArcR TR:Q9K5F3 (EMBL:Y17554) (225 aa) fasta scores: E(): 2.2e-10, 21.91% id in 219 aa; regulatory protein 2805781 2860736 SAR2710 Staphylococcus aureus subsp. aureus MRSA252 regulatory protein YP_042052.1 2805077 R 282458 CDS YP_042053.2 161761280 2859850 complement(2805880..2806821) 1 NC_002952.2 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2806821 arcC 2859850 arcC Staphylococcus aureus subsp. aureus MRSA252 carbamate kinase YP_042053.2 2805880 R 282458 CDS YP_042054.1 49484830 2859851 complement(2806838..2808274) 1 NC_002952.2 Similar to Pseudomonas aeruginosa arginine/ornithine antiporter ArcD SW:ARCD_PSEAE (P18275) (482 aa) fasta scores: E(): 7.8e-77, 46.2% id in 487 aa, and to Bacillus licheniformis permease ArcD TR:O86133 (EMBL:Y17554) (468 aa) fasta scores: E(): 1.2e-99, 59.23% id in 471 aa; arginine/ornithine antiporter 2808274 arcD 2859851 arcD Staphylococcus aureus subsp. aureus MRSA252 arginine/ornithine antiporter YP_042054.1 2806838 R 282458 CDS YP_042055.1 49484831 2859849 complement(2808359..2809369) 1 NC_002952.2 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2809369 arcB 2859849 arcB Staphylococcus aureus subsp. aureus MRSA252 ornithine carbamoyltransferase YP_042055.1 2808359 R 282458 CDS YP_042056.1 49484832 2859848 complement(2809402..2810637) 1 NC_002952.2 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 2810637 arcA 2859848 arcA Staphylococcus aureus subsp. aureus MRSA252 arginine deiminase YP_042056.1 2809402 R 282458 CDS YP_042057.1 49484833 2860737 complement(2810984..2811433) 1 NC_002952.2 Similar to Bacillus stearothermophilus regulator of arginine biosynthesis genes, arginine repressor ArgR SW:ARGR_BACST (O31408) (149 aa) fasta scores: E(): 1.3e-06, 25% id in 148 aa, and to Thermotoga maritima arginine repressor TM0371 SW:ARGR_THEMA (Q9WW19) (152 aa) fasta scores: E(): 1.1e-10, 30.46% id in 151 aa; arginine repressor family protein 2811433 2860737 SAR2715 Staphylococcus aureus subsp. aureus MRSA252 arginine repressor family protein YP_042057.1 2810984 R 282458 CDS YP_042058.1 49484834 2859883 complement(2811800..2813329) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus zinc metalloproteinase aureolysin precursor Aur SW:AURE_STAAU (P81177) (509 aa) fasta scores: E(): 7.1e-185, 99.8% id in 509 aa. Similar to Staphylococcus epidermidis extracellular elastase precursor SepA SW:SEPA_STAEP (P43148) (507 aa) fasta scores: E(): 2.3e-136, 72.29% id in 509 aa; zinc metalloproteinase aureolysin 2813329 aur 2859883 aur Staphylococcus aureus subsp. aureus MRSA252 zinc metalloproteinase aureolysin YP_042058.1 2811800 R 282458 CDS YP_042059.1 49484835 2859672 complement(2813743..2814270) 1 NC_002952.2 Poor database matches. Similar to Staphylococcus aureus immunodominant antigen B IsaB TR:Q9LAB5 (EMBL:AF144682) (175 aa) fasta scores: E(): 2.3e-53, 82.85% id in 175 aa; immunodominant antigen B 2814270 isaB 2859672 isaB Staphylococcus aureus subsp. aureus MRSA252 immunodominant antigen B YP_042059.1 2813743 R 282458 CDS YP_042060.1 49484836 2860738 2814526..2814999 1 NC_002952.2 hypothetical protein 2814999 2860738 SAR2718 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042060.1 2814526 D 282458 CDS YP_042061.1 49484837 2860739 2815239..2817113 1 NC_002952.2 Similar to Bacillus subtilis cel operon regulator CelR SW:CELR_BACSU (P46321) (641 aa) fasta scores: E(): 1e-14, 21.6% id in 648 aa, and to Streptococcus pyogenes hypothetical protein SPY1952 TR:Q99XZ1 (EMBL:AE006618) (686 aa) fasta scores: E(): 1.1e-09, 22.78% id in 689 aa; transcriptional regulator 2817113 2860739 SAR2719 Staphylococcus aureus subsp. aureus MRSA252 transcriptional regulator YP_042061.1 2815239 D 282458 CDS YP_042062.1 49484838 2860740 2817190..2819142 1 NC_002952.2 N-terminus is similar to the N-terminal region of Escherichia coli PTS system, fructose-like-1 IIBC component FrvB SW:PTVB_ECOLI (P32154) (483 aa) fasta scores: E(): 7.3e-48, 35.18% id in 469 aa, and to the C-terminal region of Xanthomonas campestris PTS system, fructose-specific IIBC component fruA SW:PTFB_XANCP (P23355) (580 aa) fasta scores: E(): 5.6e-65, 43.93% id in 478 aa; PTS transport system, IIABC component 2819142 2860740 SAR2720 Staphylococcus aureus subsp. aureus MRSA252 PTS transport system, IIABC component YP_042062.1 2817190 D 282458 CDS YP_042063.1 49484839 2859909 2819156..2820094 1 NC_002952.2 Similar to Streptococcus mutans mannose-6-phosphate isomerase Pmi SW:MANA_STRMU (Q59935) (316 aa) fasta scores: E(): 2.4e-64, 53.72% id in 309 aa, and to Lactococcus lactis mannose-6-phosphate isomerase Pmi TR:Q9CHG2 (EMBL:AE006310) (315 aa) fasta scores: E(): 1.1e-67, 52.58% id in 310 aa; mannose-6-phosphate isomerase 2820094 pmi 2859909 pmi Staphylococcus aureus subsp. aureus MRSA252 mannose-6-phosphate isomerase YP_042063.1 2819156 D 282458 CDS YP_042064.1 49484840 2860741 complement(2820206..2823187) 1 NC_002952.2 Similar to Lactococcus lactis phage infection protein pip SW:PIP_LACLA (P49022) (901 aa) fasta scores: E(): 3.3e-34, 28.14% id in 995 aa, and to Bacillus subtilis hypothetical protein YhgE SW:YHGE_BACSU (P32399) (775 aa) fasta scores: E(): 9e-19, 22.61% id in 964 aa; hypothetical protein 2823187 2860741 SAR2722 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042064.1 2820206 R 282458 CDS YP_042065.1 49484841 2860742 2823398..2825257 1 NC_002952.2 No significant database matches to the full length CDS. C-terminal region is similar to Lactococcus lactis N-acetylmuramidase AcmB TR:Q9CED5 (EMBL:AE006420) (475 aa) fasta scores: E(): 7.4e-29, 33.4% id in 482 aa, and to Streptococcus pyogenes immunogenic secreted protein precursor Isp TR:Q54707 (EMBL:U31811) (534 aa) fasta scores: E(): 1.2e-13, 26.7% id in 543 aa; N-acetylmuramoyl-L-alanine amidase 2825257 2860742 SAR2723 Staphylococcus aureus subsp. aureus MRSA252 N-acetylmuramoyl-L-alanine amidase YP_042065.1 2823398 D 282458 CDS YP_042066.1 49484842 2860743 complement(2825522..2826082) 1 NC_002952.2 Similar to an internal region of Escherichia coli isochorismatase EntB SW:ENTB_ECOLI (P15048) (285 aa) fasta scores: E(): 8.9e-08, 27.84% id in 176 aa, and to the full length Thermoplasma acidophilum N-carbamoylsarcosine amidase related protein TA1053 TR:Q9HJB7 (EMBL:AL445066) (192 aa) fasta scores: E(): 3e-08, 23.83% id in 193 aa; isochorismatase 2826082 2860743 SAR2724 Staphylococcus aureus subsp. aureus MRSA252 isochorismatase YP_042066.1 2825522 R 282458 CDS YP_042067.1 49484843 2859122 complement(2826250..2828133) 1 NC_002952.2 Poor database matches. Similar to Mycoplasma hominis Lmp1 TR:Q49525 (EMBL:U21962) (1365 aa) fasta scores: E(): 0.0062, 21.78% id in 606 aa. Possible LPXAG-sorted surface protein; surface anchored protein 2828133 sasF 2859122 sasF Staphylococcus aureus subsp. aureus MRSA252 surface anchored protein YP_042067.1 2826250 R 282458 CDS YP_042068.1 49484844 2860744 complement(2828375..2829733) 1 NC_002952.2 Poor database matches. Similar to Streptococcus cristatus hypothetical protein TR:Q9KX32 (EMBL:U96166) (442 aa) fasta scores: E(): 1.3e-54, 38.83% id in 448 aa; hypothetical protein 2829733 2860744 SAR2726 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042068.1 2828375 R 282458 CDS YP_042069.1 49484845 2860745 complement(2829726..2831234) 1 NC_002952.2 Weakly similar to Lactococcus lactis lipopolysaccharide biosynthesis protein YohH TR:Q9CFL5 (EMBL:AE006375) (541 aa) fasta scores: E(): 2.9e-17, 24.01% id in 533 aa. C-terminal region is similar to Homo sapiens N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein PIGA SW:PIGA_HUMAN (P37287) (484 aa) fasta scores: E(): 2.2e-06, 20.44% id in 406 aa; hypothetical protein 2831234 2860745 SAR2727 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042069.1 2829726 R 282458 CDS YP_042070.1 49484846 2860746 complement(2831252..2833642) 1 NC_002952.2 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins; preprotein translocase subunit SecA 2833642 2860746 SAR2728 Staphylococcus aureus subsp. aureus MRSA252 preprotein translocase subunit SecA YP_042070.1 2831252 R 282458 CDS YP_042071.1 49484847 2860747 complement(2833632..2834591) 1 NC_002952.2 Poor database matches. N-terminal region is similar to Streptococcus gordonii hypothetical protein TR:Q9AET7 (EMBL:AY028381) (159 aa) fasta scores: E(): 7.7e-15, 37.12% id in 132 aa; hypothetical protein 2834591 2860747 SAR2729 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042071.1 2833632 R 282458 CDS YP_042072.1 49484848 2860748 complement(2834569..2836137) 1 NC_002952.2 Poor database matches. Similar to Streptococcus gordonii hypothetical protein TR:Q9AET8 (EMBL:AY028381) (510 aa) fasta scores: E(): 2.7e-76, 39.02% id in 515 aa; hypothetical protein 2836137 2860748 SAR2730 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042072.1 2834569 R 282458 CDS YP_042073.1 49484849 2860750 complement(2837691..2838902) 1 NC_002952.2 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 2838902 secY 2860750 secY Staphylococcus aureus subsp. aureus MRSA252 preprotein translocase subunit SecY YP_042073.1 2837691 R 282458 CDS YP_042074.1 49484850 2859119 complement(2839031..2843086) 1 NC_002952.2 Similar to the N-terminal region of Streptococcus gordonii streptococcal hemagglutinin Hsa TR:Q9KWR3 (EMBL:AB029393) (2178 aa) fasta scores: E(): 1.2e-52, 33.82% id in 1369 aa, and the C-terminal of Staphylococcus epidermidis cell-surface adhesin SdrF TR:Q9KI14 (EMBL:AF245041) (1733 aa) fasta scores: E(): 9.2e-35, 32.35% id in 1332 aa. CDS contains a serine rich region, residues 752 to 1287. Probable LPXTG-sorted surface protein; serine-rich repeat-containing protein 2843086 sasA 2859119 sasA Staphylococcus aureus subsp. aureus MRSA252 serine-rich repeat-containing protein YP_042074.1 2839031 R 282458 CDS YP_042075.1 49484851 2860751 complement(2843633..2844325) 1 NC_002952.2 Similar to Rhizobium loti hypothetical protein MLL0910 TR:BAB48397 (EMBL:AP002996) (202 aa) fasta scores: E(): 4.7e-24, 40.84% id in 213 aa, and to Aquifex aeolicus hypothetical protein AQ_928 TR:O67071 (EMBL:AE000714) (196 aa) fasta scores: E(): 3e-18, 36.78% id in 174 aa; hypothetical protein 2844325 2860751 SAR2735 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042075.1 2843633 R 282458 CDS YP_042076.1 49484852 2860753 2845569..2845871 1 NC_002952.2 hypothetical protein 2845871 2860753 SAR2738 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042076.1 2845569 D 282458 CDS YP_042077.1 49484853 2860754 2846021..2846380 1 NC_002952.2 No significant database matches. N-terminal region is similar to Staphylococcus carnosus N5,N10-methylenetetrahydromethanopterin reductase homologue SceB TR:O54485 (EMBL:U96107) (61 aa) fasta scores: E(): 3.2e-06, 50% id in 58 aa; hypothetical protein 2846380 2860754 SAR2739 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042077.1 2846021 D 282458 CDS YP_042078.1 49484854 2860755 complement(2846465..2847076) 1 NC_002952.2 Similar to Bacillus subtilis hypothetical protein YwrF TR:O05220 (EMBL:Z93767) (205 aa) fasta scores: E(): 1.4e-36, 50% id in 204 aa, and to Bacillus halodurans hypothetical protein BH2278 TR:Q9KAK9 (EMBL:AP001515) (209 aa) fasta scores: E(): 3.7e-30, 42.78% id in 201 aa; hypothetical protein 2847076 2860755 SAR2740 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042078.1 2846465 R 282458 CDS YP_042079.1 49484855 2860756 complement(2847155..2847631) 1 NC_002952.2 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; a fusion protein of this enzyme with MsrB provides protection against oxidative stress in Neisseria gonorrhoeae; methionine sulfoxide reductase A 2847631 2860756 SAR2741 Staphylococcus aureus subsp. aureus MRSA252 methionine sulfoxide reductase A YP_042079.1 2847155 R 282458 CDS YP_042080.1 49484856 2860757 complement(2847634..2848134) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YveC TR:Q9CDZ4 (EMBL:AE006436) (164 aa) fasta scores: E(): 1.3e-22, 43.22% id in 155 aa. Weak similarity to Saccharomyces cerevisiae glucosamine-phosphate N-acetyltransferase GNA1 SW:GNA1_YEAST (P43577) (159 aa) fasta scores: E(): 0.03, 26.49% id in 151 aa; acetyltransferase (GNAT) family protein 2848134 2860757 SAR2742 Staphylococcus aureus subsp. aureus MRSA252 acetyltransferase (GNAT) family protein YP_042080.1 2847634 R 282458 CDS YP_042081.1 49484857 2860758 complement(2848369..2849136) 1 NC_002952.2 Similar to Staphylococcus aureus type 1 capsule synthesis protein CapC SW:CAPC_STAAU (P39852) (255 aa) fasta scores: E(): 6.5e-57, 56.47% id in 255 aa, and to Staphylococcus aureus type 5 capsule synthesis protein Cap5C TR:P95697 (EMBL:U81973) (254 aa) fasta scores: E(): 3.2e-51, 53.33% id in 255 aa, and to Staphylococcus aureus type 8 capsule synthesis protein Cap8C TR:P72369 (EMBL:U73374) (254 aa) fasta scores: E(): 3.7e-51, 53.33% id in 255 aa. Similar to SAR0153, 52.549% identity (53.175% ungapped) in 255 aa overlap; capsule synthesis protein 2849136 2860758 SAR2743 Staphylococcus aureus subsp. aureus MRSA252 capsule synthesis protein YP_042081.1 2848369 R 282458 CDS YP_042082.1 49484858 2860759 complement(2849133..2849825) 1 NC_002952.2 Similar to Staphylococcus aureus type 1 capsule synthesis protein CapB SW:CAPB_STAAU (P39851) (228 aa) fasta scores: E(): 5.1e-51, 60.08% id in 228 aa, and to Staphylococcus aureus type 5 capsule synthesis protein Cap5B TR:P95696 (EMBL:U81973) (228 aa) fasta scores: E(): 2.2e-48, 58.07% id in 229 aa, and to Staphylococcus aureus type 8 capsule synthesis protein Cap8B TR:P72368 (EMBL:U73374) (228 aa) fasta scores: E(): 1.8e-47, 57.2% id in 229 aa. Similar to SAR0152, 55.895% identity (56.140% ungapped) in 229 aa overlap; capsule synthesis protein 2849825 2860759 SAR2744 Staphylococcus aureus subsp. aureus MRSA252 capsule synthesis protein YP_042082.1 2849133 R 282458 CDS YP_042083.1 49484859 2860760 complement(2849842..2850504) 1 NC_002952.2 Similar to Staphylococcus aureus type 1 capsule synthesis protein CapA SW:CAPA_STAAU (P39850) (221 aa) fasta scores: E(): 3e-39, 53.18% id in 220 aa, and to Staphylococcus aureus type 5 capsule synthesis protein Cap5A TR:P95695 (EMBL:U81973) (222 aa) fasta scores: E(): 3.5e-38, 52.48% id in 221 aa, and to Staphylococcus aureus type 8 capsule synthesis protein Cap8A TR:P72367 (EMBL:U73374) (222 aa) fasta scores: E(): 5.3e-38, 52.03% id in 221 aa. Similar to SAR0151, 52.489% identity (52.727% ungapped) in 221 aa overlap; capsule synthesis protein 2850504 2860760 SAR2745 Staphylococcus aureus subsp. aureus MRSA252 capsule synthesis protein YP_042083.1 2849842 R 282458 CDS YP_042084.1 49484860 2859659 complement(2851350..2851910) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus intercellular adhesion (ica) operon transcriptional regulator IcaR TR:Q9RQQ0 (EMBL:AF086783) (186 aa) fasta scores: E(): 1.1e-64, 99.46% id in 186 aa. Similar to Staphylococcus caprae ica operon transcriptional regulator IcaR TR:Q9AIQ9 (EMBL:AF246926) (190 aa) fasta scores: E(): 2.5e-44, 67.02% id in 185 aa; ica operon transcriptional regulator 2851910 icaR 2859659 icaR Staphylococcus aureus subsp. aureus MRSA252 ica operon transcriptional regulator YP_042084.1 2851350 R 282458 CDS YP_042085.1 49484861 2859655 2852074..2853312 1 NC_002952.2 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 2853312 icaA 2859655 icaA Staphylococcus aureus subsp. aureus MRSA252 N-glycosyltransferase YP_042085.1 2852074 D 282458 CDS YP_042086.1 49484862 2859658 2853276..2853581 1 NC_002952.2 Previously sequenced as Staphylococcus aureus intercellular adhesion protein D IcaD TR:Q9RQP8 (EMBL:AF086783) (101 aa) fasta scores: E(): 5.7e-38, 98.02% id in 101 aa. Similar to Staphylococcus caprae intercellular adhesion protein D IcaD TR:Q9AIQ7 (EMBL:AF246926) (101 aa) fasta scores: E(): 2.8e-25, 65.34% id in 101 aa; intercellular adhesion protein D 2853581 icaD 2859658 icaD Staphylococcus aureus subsp. aureus MRSA252 intercellular adhesion protein D YP_042086.1 2853276 D 282458 CDS YP_042087.1 49484863 2859656 2853578..2854450 1 NC_002952.2 Previously sequenced as Staphylococcus aureus intercellular adhesion protein B IcaB TR:Q9RQP7 (EMBL:AF086783) (290 aa) fasta scores: E(): 9.7e-109, 97.58% id in 290 aa. Similar to Staphylococcus caprae intercellular adhesion protein B IcaB TR:Q9AIQ6 (EMBL:AF246926) (289 aa) fasta scores: E(): 3.7e-73, 65.39% id in 289 aa; intercellular adhesion protein B 2854450 icaB 2859656 icaB Staphylococcus aureus subsp. aureus MRSA252 intercellular adhesion protein B YP_042087.1 2853578 D 282458 CDS YP_042088.1 49484864 2859657 2854437..2855489 1 NC_002952.2 Previously sequenced as Staphylococcus aureus intercellular adhesion protein C IcaC TR:Q9RQP6 (EMBL:AF086783) (350 aa) fasta scores: E(): 1.4e-121, 99.14% id in 350 aa. Similar to Staphylococcus caprae intercellular adhesion protein C IcaC TR:Q9AIQ5 (EMBL:AF246927) (357 aa) fasta scores: E(): 3.5e-100, 78.28% id in 350 aa; intercellular adhesion protein C 2855489 icaC 2859657 icaC Staphylococcus aureus subsp. aureus MRSA252 intercellular adhesion protein C YP_042088.1 2854437 D 282458 CDS YP_042089.1 49484865 2860761 2855632..2855799 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 2855799 2860761 SAR2752 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042089.1 2855632 D 282458 CDS YP_042090.1 49484866 2859804 complement(2855881..2857926) 1 NC_002952.2 Similar to Staphylococcus epidermidis lipase precursor GehC SW:LIP_STAEP (Q02510) (688 aa) fasta scores: E(): 5.1e-123, 60.91% id in 701 aa. Previously sequenced as Staphylococcus aureus glycerol ester hydrolase lip TR:Q59811 (EMBL:M90693) (682 aa) fasta scores: E(): 0, 97.5% id in 682 aa; lipase precursor 2857926 lip 2859804 lip Staphylococcus aureus subsp. aureus MRSA252 lipase precursor YP_042090.1 2855881 R 282458 CDS YP_042091.1 49484867 2860714 complement(2859014..2859646) 1 NC_002952.2 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP 2859646 hisIE 2860714 hisIE Staphylococcus aureus subsp. aureus MRSA252 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP YP_042091.1 2859014 R 282458 CDS YP_042092.1 49484868 2860711 complement(2859643..2860401) 1 NC_002952.2 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2860401 hisF 2860711 hisF Staphylococcus aureus subsp. aureus MRSA252 imidazole glycerol phosphate synthase subunit HisF YP_042092.1 2859643 R 282458 CDS YP_042093.1 49484869 2860708 complement(2860398..2861102) 1 NC_002952.2 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2861102 hisA 2860708 hisA Staphylococcus aureus subsp. aureus MRSA252 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_042093.1 2860398 R 282458 CDS YP_042094.1 49484870 2860713 complement(2861095..2861673) 1 NC_002952.2 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2861673 hisH 2860713 hisH Staphylococcus aureus subsp. aureus MRSA252 imidazole glycerol phosphate synthase subunit HisH YP_042094.1 2861095 R 282458 CDS YP_042095.1 49484871 2860709 complement(2861670..2862248) 1 NC_002952.2 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 2862248 hisB 2860709 hisB Staphylococcus aureus subsp. aureus MRSA252 imidazoleglycerol-phosphate dehydratase YP_042095.1 2861670 R 282458 CDS YP_042096.1 49484872 2860762 complement(2862217..2863230) 1 NC_002952.2 Similar to Escherichia coli histidinol-phosphate aminotransferase HisC SW:HIS8_ECOLI (P06986) (356 aa) fasta scores: E(): 3.2e-16, 27% id in 337 aa, and to Deinococcus radiodurans histidinol-phosphate aminotransferase DR2461 TR:Q9RRM7 (EMBL:AE002075) (361 aa) fasta scores: E(): 1.4e-18, 28.03% id in 321 aa. CDS is truncated at the N-terminus in comparison to orthologues; aminotransferase 2863230 2860762 SAR2759 Staphylococcus aureus subsp. aureus MRSA252 aminotransferase YP_042096.1 2862217 R 282458 CDS YP_042097.1 49484873 2860710 complement(2863246..2864502) 1 NC_002952.2 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2864502 hisD 2860710 hisD Staphylococcus aureus subsp. aureus MRSA252 histidinol dehydrogenase YP_042097.1 2863246 R 282458 CDS YP_042098.1 49484874 2860712 complement(2864489..2865103) 1 NC_002952.2 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ; ATP phosphoribosyltransferase catalytic subunit 2865103 hisG 2860712 hisG Staphylococcus aureus subsp. aureus MRSA252 ATP phosphoribosyltransferase catalytic subunit YP_042098.1 2864489 R 282458 CDS YP_042099.1 49484875 2860763 complement(2865121..2865939) 1 NC_002952.2 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine; ATP phosphoribosyltransferase regulatory subunit 2865939 hisZ 2860763 hisZ Staphylococcus aureus subsp. aureus MRSA252 ATP phosphoribosyltransferase regulatory subunit YP_042099.1 2865121 R 282458 CDS YP_042100.1 49484876 2860764 complement(2866243..2867367) 1 NC_002952.2 hypothetical protein 2867367 2860764 SAR2763 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042100.1 2866243 R 282458 CDS YP_042101.1 49484877 2860765 complement(2867485..2867982) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH1868 TR:Q9KBQ7 (EMBL:AP001513) (163 aa) fasta scores: E(): 0.004, 24.67% id in 154 aa, and to Streptomyces coelicolor acetyltransferase SCJ9A.01 TR:Q9S1R9 (EMBL:AL109972) (177 aa) fasta scores: E(): 0.005, 26.71% id in 146 aa; hypothetical protein 2867982 2860765 SAR2764 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042101.1 2867485 R 282458 CDS YP_042102.1 49484878 2860766 complement(2868029..2868862) 1 NC_002952.2 Similar to Lactococcus lactis ABC transporter permease YdcF TR:Q9CIN0 (EMBL:AE006269) (273 aa) fasta scores: E(): 3.5e-56, 55.07% id in 276 aa, and to Mycoplasma pulmonis ABC transporter permease MYPU_3880 TR:CAC13561 (EMBL:AL445564) (296 aa) fasta scores: E(): 4.3e-12, 26.76% id in 284 aa; ABC transporter permease 2868862 2860766 SAR2765 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_042102.1 2868029 R 282458 CDS YP_042103.1 49484879 2860767 complement(2868859..2870571) 1 NC_002952.2 Similar to Lactococcus lactis ABC transporter ATP binding protein YdcE TR:Q9CIN1 (EMBL:AE006269) (565 aa) fasta scores: E(): 1.9e-93, 47.79% id in 567 aa, and to Pyrococcus horikoshii 284aa long hypothetical cobalt transport ATP-binding protein PH1815 TR:O59479 (EMBL:AP000007) (284 aa) fasta scores: E(): 9.5e-24, 34.95% id in 246 aa; ABC transporter ATP-binding protein 2870571 2860767 SAR2766 Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_042103.1 2868859 R 282458 CDS YP_042104.1 49484880 2860768 complement(2870624..2871178) 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YdcD TR:Q9CIN2 (EMBL:AE006269) (182 aa) fasta scores: E(): 8.5e-34, 51.64% id in 182 aa, and to Streptococcus pyogenes hypothetical protein SPY1899 TR:Q99Y30 (EMBL:AE006614) (156 aa) fasta scores: E(): 0.23, 28.97% id in 107 aa; hypothetical protein 2871178 2860768 SAR2767 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042104.1 2870624 R 282458 CDS YP_042105.1 49484881 2860769 complement(2871207..2872055) 1 NC_002952.2 Similar to Helicobacter pylori conserved hypothetical protein HP0709 TR:O25413 (EMBL:AE000584) (300 aa) fasta scores: E(): 2.1e-53, 50.54% id in 277 aa, and to Methanococcus jannaschii hypothetical protein MJ1651 SW:YG51_METJA (Q59045) (263 aa) fasta scores: E(): 4.3e-17, 30.51% id in 272 aa; hypothetical protein 2872055 2860769 SAR2768 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042105.1 2871207 R 282458 CDS YP_042106.1 49484882 2860770 2872437..2872952 1 NC_002952.2 Similar to Thermoplasma volcanium hypothetical protein TVG0219791 TR:BAB59353 (EMBL:AP000991) (177 aa) fasta scores: E(): 1.8e-20, 40% id in 170 aa, and to Thermoplasma acidophilum hypothetical protein TA0132 TR:Q9HLU3 (EMBL:AL445063) (180 aa) fasta scores: E(): 4.7e-19, 40.6% id in 165 aa; hypothetical protein 2872952 2860770 SAR2769 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042106.1 2872437 D 282458 CDS YP_042107.1 49484883 2859608 complement(2873098..2874072) 1 NC_002952.2 Highly similar to Staphylococcus aureus beta-lactam induced protein Drp35 TR:Q9S0S3 (EMBL:AB030228) (323 aa) fasta scores: E(): 1.5e-130, 96.59% id in 323 aa. Similar to Xylella fastidiosa hypothetical protein XF1742 TR:Q9PCN6 (EMBL:AE003997) (356 aa) fasta scores: E(): 2.6e-50, 46.45% id in 310 aa. CDS is truncated at the N-terminus in comparison to Xylella fastidiosa protein; hypothetical protein 2874072 drp35 2859608 drp35 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042107.1 2873098 R 282458 CDS YP_042108.1 49484884 2860771 2874313..2875269 1 NC_002952.2 Similar to Lactococcus lactis hypothetical protein YmdE TR:Q9CG88 (EMBL:U92974) (319 aa) fasta scores: E(): 3.9e-86, 67.42% id in 307 aa, and to Bacillus subtilis hypothetical protein YbfQ TR:O31457 (EMBL:AB006424) (322 aa) fasta scores: E(): 1.5e-83, 62.65% id in 316 aa; hypothetical protein 2875269 2860771 SAR2771 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042108.1 2874313 D 282458 CDS YP_042109.1 49484885 2861482 2875422..2876060 1 NC_002952.2 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 2876060 pcp 2861482 pcp Staphylococcus aureus subsp. aureus MRSA252 pyrrolidone-carboxylate peptidase YP_042109.1 2875422 D 282458 CDS YP_042110.1 49484886 2860772 2876163..2876627 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans hypothetical protein BH0999 TR:Q9KE59 (EMBL:AP001510) (155 aa) fasta scores: E(): 0.031, 21.62% id in 148 aa; hypothetical protein 2876627 2860772 SAR2773 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042110.1 2876163 D 282458 CDS YP_042111.1 49484887 2859239 complement(2876788..2880339) 1 NC_002952.2 Previously sequenced as Staphylococcus aureus collagen adhesin precursor Cna SW:CNA_STAAU (Q53654) (1183 aa) fasta scores: E(): 0, 97.97% id in 1183 aa. N-terminal region is similar to Enterococcus faecalis collagen adhesin precursor Ace TR:Q9F866 (EMBL:AF260873) (721 aa) fasta scores: E(): 1.8e-14, 25.78% id in 698 aa. CDS contains a repeat region (187 amino acids x3), residues 533 to 1094. Probable LPXTG-sorted surface protein; collagen adhesin precursor 2880339 cna 2859239 cna Staphylococcus aureus subsp. aureus MRSA252 collagen adhesin precursor YP_042111.1 2876788 R 282458 CDS YP_042112.1 49484888 2860773 2880717..2882135 1 NC_002952.2 Similar to the C-terminal region of Spinacia oleracea 2-oxoglutarate/malate translocator, chloroplast precursor SODiT1 SW:SOT1_SPIOL (Q41364) (569 aa) fasta scores: E(): 4.1e-81, 46.03% id in 467 aa, and to the full length Bacillus subtilis hypothetical protein YflS TR:O34726 (EMBL:Z99108) (478 aa) fasta scores: E(): 3.4e-100, 54.77% id in 471 aa; sodium:sulfate symporter family protein 2882135 2860773 SAR2775 Staphylococcus aureus subsp. aureus MRSA252 sodium:sulfate symporter family protein YP_042112.1 2880717 D 282458 CDS YP_042113.1 49484889 2860774 complement(2882684..2883592) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH3866 TR:Q9K666 (EMBL:AP001520) (308 aa) fasta scores: E(): 1.1e-46, 46.4% id in 306 aa, and to Vibrio cholerae RarD protein VC0195 TR:Q9KVF1 (EMBL:AE004110) (302 aa) fasta scores: E(): 6.2e-38, 39.78% id in 284 aa; hypothetical protein 2883592 2860774 SAR2776 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042113.1 2882684 R 282458 CDS YP_042114.1 49484890 2860775 2883814..2884389 1 NC_002952.2 Poor database matches. Weakly similar to the C-terminal region of Mycobacterium tuberculosis RNA polymerase sigma factor sigg or rv0182c or mtci28.22C TR:O07426 (EMBL:Z97050) (370 aa) fasta scores: E(): 4, 24.71% id in 178 aa; hypothetical protein 2884389 2860775 SAR2777 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042114.1 2883814 D 282458 CDS YP_042115.1 49484891 2860776 2884553..2885569 1 NC_002952.2 Similar to Alcaligenes eutrophus high-affinity nickel transport protein HoxN SW:HOXN_ALCEU (P23516) (351 aa) fasta scores: E(): 4e-52, 44.2% id in 328 aa, and to Helicobacter pylori J99 high-affinity nickel-transport protein JHP0348 SW:NIXA_HELPJ (Q9ZM74) (331 aa) fasta scores: E(): 1.5e-63, 53.15% id in 333 aa; nickel transport protein 2885569 2860776 SAR2778 Staphylococcus aureus subsp. aureus MRSA252 nickel transport protein YP_042115.1 2884553 D 282458 CDS YP_042116.1 49484892 2859038 2885811..2886611 1 NC_002952.2 Similar to Salmonella typhimurium N-hydroxyarylamine O-acetyltransferase NhoA SW:NHOA_SALTY (Q00267) (281 aa) fasta scores: E(): 1.2e-13, 27.38% id in 241 aa, and to Caulobacter crescentus N-hydroxyarylamine O-acetyltransferase CC1563 TR:Q9A803 (EMBL:AE005831) (275 aa) fasta scores: E(): 1.4e-13, 30.64% id in 248 aa; N-acetyltransferase 2886611 2859038 SAR2779 Staphylococcus aureus subsp. aureus MRSA252 N-acetyltransferase YP_042116.1 2885811 D 282458 CDS YP_042117.1 49484893 2859039 complement(2886913..2887425) 1 NC_002952.2 Similar to Pseudomonas aeruginosa hypothetical protein PA5409 TR:Q9HTF5 (EMBL:AE004953) (186 aa) fasta scores: E(): 0.0044, 22.48% id in 169 aa, and to Methanothermobacter thermautotrophicus hypothetical protein MTH881 TR:O26967 (EMBL:AE000864) (168 aa) fasta scores: E(): 0.05, 25.15% id in 159 aa; hypothetical protein 2887425 2859039 SAR2780 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042117.1 2886913 R 282458 CDS YP_042118.1 49484894 2860428 2887715..2888473 1 NC_002952.2 Previously sequenced as Staphylococcus aureus ABC transporter ATP-binding protein, up-regulated in vancomycin-resistant strains, VraD TR:Q9RL74 (EMBL:Y18641) (252 aa) fasta scores: E(): 4e-80, 99.6% id in 252 aa. Similar to Bacillus halodurans ABC transporter BH3913 TR:Q9K619 (EMBL:AP001520) (253 aa) fasta scores: E(): 1.1e-48, 59.92% id in 252 aa. Similar to SAR0671, 63.200% identity (63.454% ungapped) in 250 aa overlap; ABC transporter ATP-binding protein 2888473 vraD 2860428 vraD Staphylococcus aureus subsp. aureus MRSA252 ABC transporter ATP-binding protein YP_042118.1 2887715 D 282458 CDS YP_042119.1 49484895 2860429 2888463..2890343 1 NC_002952.2 Previously sequenced as Staphylococcus aureus ABC transporter permease, up-regulated in vancomycin-resistant strains, VraE TR:Q9KWJ6 (EMBL:AB035452) (626 aa) fasta scores: E(): 3.1e-195, 95.36% id in 626 aa. Similar to Bacillus subtilis YtsD TR:O34741 (EMBL:AF008220) (646 aa) fasta scores: E(): 9.7e-40, 31.89% id in 649 aa; ABC transporter permease 2890343 vraE 2860429 vraE Staphylococcus aureus subsp. aureus MRSA252 ABC transporter permease YP_042119.1 2888463 D 282458 CDS YP_042120.1 49484896 2859040 2890435..2890626 1 NC_002952.2 No significant database matches. Doubtful CDS; hypothetical protein 2890626 2859040 SAR2783 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042120.1 2890435 D 282458 CDS YP_042121.1 49484897 2859042 complement(2891713..2892210) 1 NC_002952.2 hypothetical protein 2892210 2859042 SAR2787 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042121.1 2891713 R 282458 CDS YP_042122.1 49484898 2859043 complement(2892212..2892961) 1 NC_002952.2 No significant database matches to the full length CDS. C-terminus is similar to the C-terminal region of Neisseria meningitidis hypothetical protein NMB0372 TR:Q9K122 (EMBL:AE002393) (225 aa) fasta scores: E(): 2.7e-05, 52% id in 75 aa; hypothetical protein 2892961 2859043 SAR2788 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042122.1 2892212 R 282458 CDS YP_042123.1 49484899 2859044 complement(2892980..2893783) 1 NC_002952.2 Poor database matches. Similar to internal regions of Bacillus subtilis minor extracellular protease precursor Epr SW:SUBE_BACSU (P16396) (645 aa) fasta scores: E(): 8.8e-17, 32.35% id in 204 aa, and Bacillus licheniformis subtilisin carlsberg precursor Apr SW:SUBT_BACLI (P00780) (379 aa) fasta scores: E(): 4e-16, 33.81% id in 207 aa; subtilase protease 2893783 2859044 SAR2789 Staphylococcus aureus subsp. aureus MRSA252 subtilase protease YP_042123.1 2892980 R 282458 CDS YP_042124.1 49484900 2859248 2894239..2894466 1 NC_002952.2 Similar to Bacillus subtilis cold shock protein CspC SW:CSPC_BACSU (P39158) (66 aa) fasta scores: E(): 1.8e-17, 73.43% id in 64 aa. Previously sequenced as Staphylococcus aureus cold shock protein CspB TR:O33591 (EMBL:AF003592) (66 aa) fasta scores: E(): 6.4e-25, 100% id in 66 aa. Similar to SAR0848, 80.952% identity (80.952% ungapped) in 63 aa overlap SAR1414, 73.016% identity (73.016% ungapped) in 63 aa overlap; cold shock protein 2894466 cspB 2859248 cspB Staphylococcus aureus subsp. aureus MRSA252 cold shock protein YP_042124.1 2894239 D 282458 CDS YP_042125.1 49484901 2859045 complement(2894593..2895162) 1 NC_002952.2 Similar to Streptococcus pyogenes hypothetical protein SPY1834 TR:Q99Y76 (EMBL:AE006610) (195 aa) fasta scores: E(): 2.1e-17, 37.3% id in 193 aa, and to Bacillus pumilus plasmid pSH1452 similar hypothetical protein TR:O33867 (EMBL:U53767) (211 aa) fasta scores: E(): 0.0009, 30.19% id in 202 aa; hypothetical protein 2895162 2859045 SAR2791 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042125.1 2894593 R 282458 CDS YP_042126.1 49484902 2859046 complement(2895415..2895810) 1 NC_002952.2 Poor database matches. Similar to Bacillus halodurans hypothetical protein BH0644 TR:Q9KF42 (EMBL:AP001509) (112 aa) fasta scores: E(): 0.1, 22.44% id in 98 aa; hypothetical protein 2895810 2859046 SAR2792 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042126.1 2895415 R 282458 CDS YP_042127.1 49484903 2859047 complement(2895878..2896231) 1 NC_002952.2 Similar to Bacillus halodurans hypothetical protein BH0644 TR:Q9KF42 (EMBL:AP001509) (112 aa) fasta scores: E(): 7.1, 22.43% id in 107 aa, and to Rhizobium loti hypothetical protein MLR8402 TR:BAB54292 (EMBL:AP003014) (109 aa) fasta scores: E(): 8.1, 26.92% id in 104 aa; hypothetical protein 2896231 2859047 SAR2793 Staphylococcus aureus subsp. aureus MRSA252 hypothetical protein YP_042127.1 2895878 R 282458 CDS YP_042128.1 49484904 2859048 complement(2896726..2897565) 1 NC_002952.2 Similar to Bacillus halodurans DNA-binding protein Spo0J-like homologue BH4059 TR:Q9K5M9 (EMBL:AP001520) (283 aa) fasta scores: E(): 5.7e-39, 47.36% id in 285 aa, and to Bacillus subtilis hypothetical protein YyaA SW:YYAA_BACSU (P37524) (283 aa) fasta scores: E(): 6.7e-38, 48.23% id in 284 aa; DNA-binding protein 2897565 2859048 SAR2795 Staphylococcus aureus subsp. aureus MRSA252 DNA-binding protein YP_042128.1 2896726 R 282458 CDS YP_042129.1 49484905 2859915 complement(2897608..2898327) 1 NC_002952.2 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 2898327 gidB 2859915 gidB Staphylococcus aureus subsp. aureus MRSA252 16S rRNA methyltransferase GidB YP_042129.1 2897608 R 282458 CDS YP_042130.1 49484906 2859914 complement(2898327..2900204) 1 NC_002952.2 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 2900204 gidA 2859914 gidA Staphylococcus aureus subsp. aureus MRSA252 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_042130.1 2898327 R 282458 CDS YP_042131.1 49484907 2859049 complement(2900271..2901650) 1 NC_002952.2 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 2901650 trmE 2859049 trmE Staphylococcus aureus subsp. aureus MRSA252 tRNA modification GTPase TrmE YP_042131.1 2900271 R 282458 CDS YP_042132.1 49484908 2859277 complement(2901794..2902141) 1 NC_002952.2 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 2902141 rnpA 2859277 rnpA Staphylococcus aureus subsp. aureus MRSA252 ribonuclease P YP_042132.1 2901794 R 282458 CDS YP_042133.1 49484909 2860165 complement(2902268..2902405) 1 NC_002952.2 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 2902405 rpmH 2860165 rpmH Staphylococcus aureus subsp. aureus MRSA252 50S ribosomal protein L34 YP_042133.1 2902268 R 282458 CDS