-- dump date 20140620_074214 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 282458000001 SEQ_END SEQ_END NC_002952.2 2902619 2902619 DR NC_002952.2; contig end 2902619..2902619 Staphylococcus aureus subsp. aureus MRSA252 YP_039478.1 CDS dnaA NC_002952.2 517 1878 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 517..1878 Staphylococcus aureus subsp. aureus MRSA252 2859597 YP_039479.1 CDS dnaN NC_002952.2 2156 3289 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2156..3289 Staphylococcus aureus subsp. aureus MRSA252 2859605 YP_039480.1 CDS SAR0003 NC_002952.2 3670 3915 D Similar to Bacillus subtilis hypothetical protein YaaA SW:YAAA_BACSU (P05650) (71 aa) fasta scores: E(): 3.8e-07, 48.438% id in 64 aa, and to Bacillus halodurans hypothetical protein YyaA TR:Q9RCA0 (EMBL:AB013492) (73 aa) fasta scores: E(): 6.4e-07, 46.667% id in 60 aa; hypothetical protein 3670..3915 Staphylococcus aureus subsp. aureus MRSA252 2859824 YP_039481.1 CDS recF NC_002952.2 3912 5024 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3912..5024 Staphylococcus aureus subsp. aureus MRSA252 2859301 YP_039482.1 CDS gyrB NC_002952.2 5037 6968 D Previously sequenced as Staphylococcus aureus DNA gyrase subunit B GyrB SW:GYRB_STAAU (P20832) (643 aa) fasta scores: E(): 0, 99.844% id in 643 aa, Similar to Bacillus subtilis DNA gyrase subunit B GyrB SW:GYRB_BACSU (P05652) (638 aa) fasta scores: E(): 1.8e-166, 69.194% id in 633 aa. Similar to SAR0621, 23.973% identity (26.718% ungapped) in 146 aa overlap; DNA gyrase subunit B 5037..6968 Staphylococcus aureus subsp. aureus MRSA252 2859950 YP_039483.1 CDS gyrA NC_002952.2 7005 9665 D Previously sequenced as Staphylococcus aureus DNA gyrase subunit A GyrA SW:GYRA_STAAU (P20831) (889 aa) fasta scores: E(): 0, 98.875% id in 889 aa, Similar to and to Bacillus subtilis DNA gyrase subunit A GyrA SW:GYRA_BACSU (P05653) (821 aa) fasta scores: E(): 5e-194, 64.485% id in 825 aa; DNA gyrase subunit A 7005..9665 Staphylococcus aureus subsp. aureus MRSA252 2859949 YP_039484.1 CDS SAR0007 NC_002952.2 9753 10583 R Similar to Lactococcus lactis hypothetical protein YcfG TR:Q9CIU7 (EMBL:AE006263) (275 aa) fasta scores: E(): 5.6e-41, 47.445% id in 274 aa, and to Streptococcus thermophilus hypothetical protein YfoL SW:YFOL_STRTR (P96051) (278 aa) fasta scores: E(): 1.8e-40, 46.241% id in 266 aa; hypothetical protein complement(9753..10583) Staphylococcus aureus subsp. aureus MRSA252 2859825 YP_039485.1 CDS hutH NC_002952.2 10891 12405 D catalyzes the degradation of histidine to urocanate and ammmonia; histidine ammonia-lyase 10891..12405 Staphylococcus aureus subsp. aureus MRSA252 2859650 YP_039486.1 CDS serS NC_002952.2 12783 14069 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 12783..14069 Staphylococcus aureus subsp. aureus MRSA252 2859138 YP_039487.1 CDS SAR0010 NC_002952.2 14713 15408 D Similar to Bacillus subtilis probable branched-chain amino acid transport protein AzlC SW:AZLC_BACSU (O07942) (254 aa) fasta scores: E(): 3.5e-12, 28.182% id in 220 aa, and to Lactococcus lactis possible amino acid permease YqfD TR:Q9CF68 (EMBL:AE006391) (235 aa) fasta scores: E(): 1.6e-31, 40.773% id in 233 aa; hypothetical protein 14713..15408 Staphylococcus aureus subsp. aureus MRSA252 2859826 YP_039488.1 CDS SAR0011 NC_002952.2 15405 15734 D Similar to Lactococcus lactis hypothteical protein YqfC TR:Q9CF69 (EMBL:AE006391) (108 aa) fasta scores: E(): 2.5e-09, 35.294% id in 102 aa, and to Leishmania major hypothetical protein LM12.1384 TR:Q9GVH4 (EMBL:AL390114) (109 aa) fasta scores: E(): 0.35, 26.804% id in 97 aa; hypothetical protein 15405..15734 Staphylococcus aureus subsp. aureus MRSA252 2859827 YP_039489.1 CDS SAR0012 NC_002952.2 16096 17064 D Similar to Corynebacterium glutamicum homoserine O-acetyltransferase MetA SW:METX_CORGL (O68640) (379 aa) fasta scores: E(): 1.4e-05, 28.412% id in 359 aa, and to Thermus aquaticus homoserine O-acetyltransferase Met2 SW:METX_THETH (Q9RA51) (380 aa) fasta scores: E(): 2.7e-12, 34.783% id in 345 aa. Possible alternative translational start site; hydrolase 16096..17064 Staphylococcus aureus subsp. aureus MRSA252 2859828 YP_039490.1 CDS SAR0013 NC_002952.2 17309 18295 D Weak similarity to Bacillus halodurans hypothetical protein BH4032 TR:Q9K5Q6 (EMBL:AP001520) (312 aa) fasta scores: E(): 9.9e-12, 22.295% id in 305 aa, and to Bacillus subtilis hypothetical protein YybS SW:YYBS_BACSU (P37485) (309 aa) fasta scores: E(): 5e-10, 22.006% id in 309 aa. Possible alternative translational start site; hypothetical protein 17309..18295 Staphylococcus aureus subsp. aureus MRSA252 2859829 YP_039491.1 CDS SAR0014 NC_002952.2 18310 20277 D Similar to Bacillus subtilis hypothetical protein YybT SW:YYBT_BACSU (P37484) (659 aa) fasta scores: E(): 1.4e-114, 50.779% id in 642 aa, and to Bacillus halodurans hypothetical protein BH4031 TR:Q9K5Q7 (EMBL:AP001520) (654 aa) fasta scores: E(): 1.6e-110, 45.912% id in 636 aa; hypothetical protein 18310..20277 Staphylococcus aureus subsp. aureus MRSA252 2859830 YP_039492.1 CDS rplI NC_002952.2 20274 20720 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 20274..20720 Staphylococcus aureus subsp. aureus MRSA252 2860904 YP_039493.1 CDS dnaC NC_002952.2 20752 22152 D Similar to Salmonella typhimurium replicative DNA helicase DnaB SW:DNAB_SALTY (P10338) (471 aa) fasta scores: E(): 1.8e-61, 44.812% id in 453 aa. Previously sequenced as Staphylococcus aureus helicase DnaC TR:Q9AQH7 (EMBL:AB054590) (466 aa) fasta scores: E(): 7.9e-176, 99.785% id in 466 aa; replicative DNA helicase 20752..22152 Staphylococcus aureus subsp. aureus MRSA252 2859599 YP_039494.1 CDS purA NC_002952.2 22430 23713 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 22430..23713 Staphylococcus aureus subsp. aureus MRSA252 2860158 YP_039495.1 CDS yycF NC_002952.2 24897 25604 D Two-component regulatory system-family, response regulator protein. Previously sequenced as Staphylococcus aureus response regulator YycF TR:Q9XCM7 (EMBL:AF136709) (233 aa) fasta scores: E(): 1.5e-91, 100.000% id in 233 aa. Similar to Lactococcus lactis probable transcriptional regulatory protein ArcA TR:O86269 (EMBL:AJ001103) (233 aa) fasta scores: E(): 1.9e-57, 62.555% id in 227 aa. Similar to SAR1772, 52.155% identity (52.838% ungapped) in 232 aa overlap; response regulator protein 24897..25604 Staphylococcus aureus subsp. aureus MRSA252 2859628 YP_039496.1 CDS yycG NC_002952.2 25617 27443 D Two-component regulatory system family, sensor kinase. Previously sequenced as Staphylococcus aureus two-component sensor histidine kinase YycG TR:Q9XCM6 (EMBL:AF136709) (608 aa) fasta scores: E(): 5.5e-214, 99.836% id in 608 aa. Similar to Bacillus subtilis probable two-component sensor histidine kinase YycG TR:Q45614 (EMBL:D78193) (611 aa) fasta scores: E(): 2e-98, 46.217% id in 608 aa; sensor kinase 25617..27443 Staphylococcus aureus subsp. aureus MRSA252 2859629 YP_039497.1 CDS yycH NC_002952.2 27436 28770 D Similar to Bacillus subtilis hypothetical protein YycH TR:Q45613 (EMBL:D78193) (458 aa) fasta scores: E(): 2.7e-11, 19.697% id in 462 aa. Previously sequenced as Staphylococcus aureus hypothetical protein YycH TR:Q9RDT2 (EMBL:AJ012052) (465 aa) fasta scores: E(): 7.4e-166, 98.658% id in 447 aa. Possible alternative translational start site; hypothetical protein 27436..28770 Staphylococcus aureus subsp. aureus MRSA252 2859630 YP_039498.1 CDS yycI NC_002952.2 28771 29559 D Similar to Bacillus halodurans hypothetical protein BH4024 TR:Q9K5R4 (EMBL:AP001520) (262 aa) fasta scores: E(): 4.3e-11, 25.735% id in 272 aa. Previously sequenced as Staphylococcus aureus hypothetical protein YycI TR:Q9RDT1 (EMBL:AJ012052) (262 aa) fasta scores: E(): 4.1e-87, 97.710% id in 262 aa.; hypothetical protein 28771..29559 Staphylococcus aureus subsp. aureus MRSA252 2859631 YP_039499.1 CDS yycJ NC_002952.2 29947 30747 D Similar to Bacillus subtilis hypothetical protein YycJ TR:Q45611 (EMBL:D78193) (268 aa) fasta scores: E(): 3e-60, 62.069% id in 261 aa. Previously sequenced as Staphylococcus aureus hypothetical protein YycJ TR:Q9RDT0 (EMBL:AJ012052) (269 aa) fasta scores: E(): 2.4e-103, 99.624% id in 266 aa; metallo-beta-lactamase superfamily protein 29947..30747 Staphylococcus aureus subsp. aureus MRSA252 2859632 YP_039500.1 CDS sasH NC_002952.2 30932 33292 D Internal region is similar to Discopyge ommata 5'-nucleotidase precursor protein SW:5NTD_DISOM (P29240) (577 aa) fasta scores: E(): 3.9e-19, 28.866% id in 582 aa, and to Rhizobium loti possible 5'-nucleotidase MLR3017 TR:BAB50004 (EMBL:AP003001) (706 aa) fasta scores: E(): 5.7e-22, 28.852% id in 610 aa. Probable LPXTG-sorted surface protein; 5'-nucleotidase 30932..33292 Staphylococcus aureus subsp. aureus MRSA252 2859123 YP_039501.1 CDS SAR0024 NC_002952.2 33660 34139 D SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 33660..34139 Staphylococcus aureus subsp. aureus MRSA252 2859831 YP_039502.1 CDS SAR0025 NC_002952.2 34422 35717 D Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein TR:Q9KJC5 (EMBL:AF181950) (419 aa) fasta scores: E(): 2.6e-140, 99.752% id in 403 aa; hypothetical protein 34422..35717 Staphylococcus aureus subsp. aureus MRSA252 2859832 YP_039503.1 CDS SAR0026 NC_002952.2 36132 36371 D No significant database matches. Doubtful CDS; hypothetical protein 36132..36371 Staphylococcus aureus subsp. aureus MRSA252 2859833 YP_039504.1 CDS SAR0027 NC_002952.2 36403 37077 R Identical to Staphylococcus aureus IS431 transposase TR:BAB47631 (EMBL:AB037671) (224 aa) fasta scores: E(): 1.8e-88, 100.000% id in 224 aa, and similar to Staphylococcus epidermidis IS257 transposase Tnp TR:BAB39484 (EMBL:AB049452) (224 aa) fasta scores: E(): 1.4e-87, 99.107% id in 224 aa; transposase complement(36403..37077) Staphylococcus aureus subsp. aureus MRSA252 2859834 YP_039505.1 CDS SAR0030 NC_002952.2 38197 38373 R No significant database matches. Doubtful CDS; hypothetical protein complement(38197..38373) Staphylococcus aureus subsp. aureus MRSA252 2859835 YP_039506.1 CDS pre NC_002952.2 38396 39658 R Identical to Staphylococcus aureus plasmid (pUB110) recombination enzyme Pre SW:PRE2_STAAU (P22490) (420 aa) fasta scores: E(): 3e-135, 100.000% id in 420 aa, and highly similar to Staphylococcus cohnii plasmid (pIP1714) recombination/mobilization protein Pre TR:O87277 (EMBL:AF015628) (420 aa) fasta scores: E(): 1.1e-134, 99.762% id in 420 aa. Contains coiled-coiled domain, residues 189 to 213; plasmid recombination enzyme complement(38396..39658) Staphylococcus aureus subsp. aureus MRSA252 2860147 YP_039507.1 CDS SAR0031a NC_002952.2 39767 39907 D Doubtful CDS. No significant database hits; hypothetical protein 39767..39907 Staphylococcus aureus subsp. aureus MRSA252 2859836 YP_039508.1 CDS SAR0031b NC_002952.2 39973 40146 D Doubtful CDS. No significant database hits; hypothetical protein 39973..40146 Staphylococcus aureus subsp. aureus MRSA252 2859837 YP_039509.1 CDS ble NC_002952.2 40165 40569 R Previously sequenced as Staphylococcus aureus bleomycin resistance protein Ble TR:BAA82230 (EMBL:D86934) (134 aa) fasta scores: E(): 3.6e-57, 99.254% id in 134 aa. Similar to Bacillus subtilis hypothetical protein YraH TR:O07918 (EMBL:X92868) (128 aa) fasta scores: E(): 0.0082, 26.357% id in 129 aa; bleomycin resistance protein complement(40165..40569) Staphylococcus aureus subsp. aureus MRSA252 2859820 YP_039510.1 CDS knt NC_002952.2 40786 41556 R Highly similar to Staphylococcus aureus plasmid (pUB110) kanamycin nucleotidyltransferase Knt SW:KANU_STAAU (P05057) (253 aa) fasta scores: E(): 2.4e-104, 99.605% id in 253 aa, and to Bacillus sp plasmid (pRBH1 and pTB913) kanamycin nucleotidyltransferase Knt SW:KANU_BACSP (P05058) (253 aa) fasta scores: E(): 5.9e-104, 99.209% id in 253 aa; kanamycin nucleotidyltransferase complement(40786..41556) Staphylococcus aureus subsp. aureus MRSA252 2859686 YP_039511.1 CDS SAR0034 NC_002952.2 41749 42423 R Identical to Staphylococcus aureus IS431 transposase TR:BAB47631 (EMBL:AB037671) (224 aa) fasta scores: E(): 1.8e-88, 100.000% id in 224 aa, and similar to Staphylococcus epidermidis IS257 transposase Tnp TR:BAB39484 (EMBL:AB049452) (224 aa) fasta scores: E(): 1.4e-87, 99.107% id in 224 aa; transposase complement(41749..42423) Staphylococcus aureus subsp. aureus MRSA252 2859838 YP_039512.1 CDS SAR0036 NC_002952.2 42946 43155 D Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein TR:Q9XB76 (EMBL:D86934) (76 aa) fasta scores: E(): 2.7e-26, 100.000% id in 69 aa. CDS is 7 amino acids shorter at the C-terminus; hypothetical protein 42946..43155 Staphylococcus aureus subsp. aureus MRSA252 2859840 YP_039513.1 CDS ugpQ NC_002952.2 43605 44348 D Similar to Escherichia coli glycerophosphoryl diester phosphodiesterase UgpQ SW:UGPQ_ECOLI (P10908) (247 aa) fasta scores: E(): 1.6e-22, 35.443% id in 237 aa. Previously sequenced as Staphylococcus aureus glycerophosphoryldiester phosphodiesterase UgpQ TR:Q9S3K5 (EMBL:D86934) (247 aa) fasta scores: E(): 2e-93, 100.000% id in 247 aa; glycerophosphoryl diester phosphodiesterase 43605..44348 Staphylococcus aureus subsp. aureus MRSA252 2860411 YP_039514.1 CDS SAR0038 NC_002952.2 44445 44873 D Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47625 (EMBL:AB037671) (142 aa) fasta scores: E(): 2e-52, 100.000% id in 142 aa. Similar to Bacillus subtilis YdeM protein ydeM TR:P96670 (EMBL:AB001488) (141 aa) fasta scores: E(): 1.5e-30, 56.115% id in 139 aa; hypothetical protein 44445..44873 Staphylococcus aureus subsp. aureus MRSA252 2859841 YP_039515.1 CDS mecA NC_002952.2 44919 46925 R Identical to Staphylococcus epidermidis, and Staphylococcus aureus penicillin-binding protein 2 prime MecA TR:Q54113 (EMBL:X52592) (668 aa) fasta scores: E(): 0, 100.000% id in 668 aa, and to Staphylococcus sciuri methicillin resistanc protein MecA2 TR:O54283 (EMBL:Y13095) (668 aa) fasta scores: E(): 0, 99.102% id in 668 aa; penicillin-binding protein 2 prime complement(44919..46925) Staphylococcus aureus subsp. aureus MRSA252 2861157 YP_039516.1 CDS mecR1 NC_002952.2 47025 48782 D Highly similar to Staphylococcus epidermidis, and Staphylococcus aureus methicillin resistance protein MecR1 SW:MECR_STAEP (P26597) (585 aa) fasta scores: E(): 0, 99.829% id in 585 aa, and to Staphylococcus sciuri methicillin resistance protein MecR1 TR:CAA73546 (EMBL:Y13096) (585 aa) fasta scores: E(): 0, 99.829% id in 585 aa; methicillin resistance protein MecR1 47025..48782 Staphylococcus aureus subsp. aureus MRSA252 2861159 YP_039517.1 CDS mecI NC_002952.2 48782 49126 D Previously sequenced as Staphylococcus epidermidis, and Staphylococcus aureus methicillin resistance regulatory protein MecI SW:MECI_STAEP (P26598) (123 aa) fasta scores: E(): 2.5e-41, 100.000% id in 114 aa. Similar to and to Staphylococcus haemolyticus beta-lactamase repressor BlaI TR:Q9K4N1 (EMBL:AJ400722) (126 aa) fasta scores: E(): 9e-20, 59.649% id in 114 aa. Similar to SAR1829, 59.649% identity (59.649% ungapped) in 114 aa overlap; methicillin resistance regulatory protein MecI 48782..49126 Staphylococcus aureus subsp. aureus MRSA252 2861158 YP_039518.1 CDS SAR0042 NC_002952.2 49263 49466 D Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47620 (EMBL:AB037671) (70 aa) fasta scores: E(): 6.3e-26, 100.000% id in 67 aa; hypothetical protein 49263..49466 Staphylococcus aureus subsp. aureus MRSA252 2859842 YP_039519.1 CDS SAR0046 NC_002952.2 52251 53315 R Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47615 (EMBL:AB037671) (354 aa) fasta scores: E(): 3.9e-133, 100.000% id in 354 aa. C-terminus is similar to Bacillus subtilis hypothetical protein YrkE SW:YRKE_BACSU (P54432) (160 aa) fasta scores: E(): 7.3e-25, 52.941% id in 153 aa; hypothetical protein complement(52251..53315) Staphylococcus aureus subsp. aureus MRSA252 2859844 YP_039520.1 CDS SAR0047 NC_002952.2 53445 53711 D Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47614 (EMBL:AB037671) (88 aa) fasta scores: E(): 2.8e-29, 100.000% id in 88 aa. Similar to Lactococcus lactis hypothetical protein YhjE TR:Q9CHE5 (EMBL:AE006312) (84 aa) fasta scores: E(): 3.2e-09, 42.683% id in 82 aa; hypothetical protein 53445..53711 Staphylococcus aureus subsp. aureus MRSA252 2859845 YP_039521.1 CDS SAR0049 NC_002952.2 54694 55356 R Highly similar to Staphylococcus aureus transposon Tn554 hypothetical protein TR:Q48363 (EMBL:X03216) (220 aa) fasta scores: E(): 2.8e-82, 99.545% id in 220 aa, and to Lactococcus lactis hypothetical protein YljG TR:Q9CGB7 (EMBL:AE006350) (206 aa) fasta scores: E(): 3.2e-06, 25.837% id in 209 aa; hypothetical protein complement(54694..55356) Staphylococcus aureus subsp. aureus MRSA252 2860468 YP_039522.1 CDS ermA1 NC_002952.2 55890 56621 D Previously sequenced as Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance protein, rRNA adenine N-6-methyltransferase ErmA SW:ERM1_STAAU (P06699) (243 aa) fasta scores: E(): 1.7e-90, 100.000% id in 243 aa. Similar to Streptococcus pyogenes erythromycin resistance methylase ErmTR TR:O07480 (EMBL:AF002716) (243 aa) fasta scores: E(): 7.2e-74, 81.070% id in 243 aa; rRNA adenine N-6-methyltransferase 1 55890..56621 Staphylococcus aureus subsp. aureus MRSA252 2859614 YP_039523.1 CDS spc1 NC_002952.2 56747 57529 R Previously sequenced as Staphylococcus aureus streptomycin and spectomycin resistance protein, streptomycin 3''-adenylyltransferase Spc SW:S3AD_STAAU (P04827) (260 aa) fasta scores: E(): 4e-100, 100.000% id in 260 aa. Similar to Streptomyces coelicolor nucleotidyltransferase SCD19.10 TR:Q9F2Z2 (EMBL:AL392149) (257 aa) fasta scores: E(): 4.6e-34, 44.493% id in 227 aa; streptomycin 3''-adenylyltransferase 1 complement(56747..57529) Staphylococcus aureus subsp. aureus MRSA252 2859153 YP_039524.1 CDS tnpC1 NC_002952.2 57680 58057 R Previously sequenced as Staphylococcus aureus transposase C TnpC TR:BAB47665 (EMBL:AB037671) (125 aa) fasta scores: E(): 1.1e-36, 100.000% id in 125 aa. Similar to Clostridium butyricum similar hypothetical protein TR:Q45924 (EMBL:Z29084) (124 aa) fasta scores: E(): 2.1e-09, 41.818% id in 110 aa; transposase C 1 complement(57680..58057) Staphylococcus aureus subsp. aureus MRSA252 2859541 YP_039525.1 CDS tnpB1 NC_002952.2 58064 59956 R Previously sequenced as Staphylococcus aureus transposon Tn554 transposase B TnpB SW:TNPB_STAAU (P06697) (630 aa) fasta scores: E(): 0, 100.000% id in 630 aa. Similar to Clostridium butyricum hypothetical protein TR:Q45923 (EMBL:Z29084) (660 aa) fasta scores: E(): 1.7e-14, 24.734% id in 659 aa; transposase B 1 complement(58064..59956) Staphylococcus aureus subsp. aureus MRSA252 2859539 YP_039526.1 CDS tnpA1 NC_002952.2 59953 61038 R Previously sequenced as Staphylococcus aureus transposon Tn554 transposase A TnpA SW:TNPA_STAAU (P06696) (361 aa) fasta scores: E(): 6.8e-137, 99.723% id in 361 aa. Similar to Clostridium butyricum hypothetical protein TR:Q45922 (EMBL:Z29084) (364 aa) fasta scores: E(): 2.6e-28, 37.752% id in 347 aa; transposase A 1 complement(59953..61038) Staphylococcus aureus subsp. aureus MRSA252 2859537 YP_039527.1 CDS SAR0056 NC_002952.2 61495 62001 R Previously sequenced as Staphylococcus aureus hypothetical protein Orf N043 TR:Q9KX75 (EMBL:D86934) (168 aa) fasta scores: E(): 2.5e-62, 100.000% id in 168 aa. Similar to Escherichia coli O157:H7 hypothetical protein ECS5248 TR:BAB38671 (EMBL:AP002569) (155 aa) fasta scores: E(): 7e-07, 31.333% id in 150 aa; hypothetical protein complement(61495..62001) Staphylococcus aureus subsp. aureus MRSA252 2860470 YP_039528.1 CDS SAR0057 NC_002952.2 62019 62330 R Previously sequenced as Staphylococcus aureus hypothetical protein Orf N042 TR:Q9KX76 (EMBL:D86934) (103 aa) fasta scores: E(): 3.4e-41, 100.000% id in 103 aa; hypothetical protein complement(62019..62330) Staphylococcus aureus subsp. aureus MRSA252 2860471 YP_039529.1 CDS SAR0058 NC_002952.2 62417 62767 R Previously sequenced as Staphylococcus aureus hypothetical protein Orf N041 TR:Q9KX77 (EMBL:D86934) (116 aa) fasta scores: E(): 2.5e-47, 100.000% id in 116 aa; hypothetical protein complement(62417..62767) Staphylococcus aureus subsp. aureus MRSA252 2860472 YP_039530.1 CDS ccrB NC_002952.2 63285 64913 R Similar to Staphylococcus aureus site-specific recombinase CcrB TR:Q9XB94 (EMBL:D86934) (542 aa) fasta scores: E(): 5.6e-194, 99.815% id in 542 aa, and to lactococcal bacteriophage TP901-1 integrase Int TR:Q38184 (EMBL:X85213) (485 aa) fasta scores: E(): 2.6e-24, 28.880% id in 509 aa; site-specific recombinase complement(63285..64913) Staphylococcus aureus subsp. aureus MRSA252 2861354 YP_039531.1 CDS ccrA NC_002952.2 64935 66284 R Similar to Staphylococcus aureus, and site-specific recombinase CcrA TR:Q9XB96 (EMBL:D86934) (449 aa) fasta scores: E(): 4.4e-165, 95.323% id in 449 aa, and to Enterococcus faecalis bacteriophage phi-FC1 site-specific integrase TR:Q9XJF6 (EMBL:AF124258) (464 aa) fasta scores: E(): 8.9e-18, 26.154% id in 455 aa; site-specific recombinase complement(64935..66284) Staphylococcus aureus subsp. aureus MRSA252 2861353 YP_039532.1 CDS SAR0061 NC_002952.2 66518 68311 R Similar to Staphylococcus aureus hypothetical protein Orf N031TR:Q9KX82 (EMBL:D86934) (597 aa) fasta scores: E(): 0, 97.822% id in 597 aa. N-terminus is similar to SAR0075, 60.068% identity (60.690% ungapped) in 293 aa overlap and C-terminus is similar to SAR0074, 50.530% identity (51.254% ungapped) in 283 aa overlap; hypothetical protein complement(66518..68311) Staphylococcus aureus subsp. aureus MRSA252 2860473 YP_039533.1 CDS SAR0062 NC_002952.2 68311 68607 R Previously sequenced as Staphylococcus aureus hypothetical protein Orf N030 TR:Q9KX83 (EMBL:D86934) (98 aa) fasta scores: E(): 3e-41, 100.000% id in 98 aa; hypothetical protein complement(68311..68607) Staphylococcus aureus subsp. aureus MRSA252 2860474 YP_039534.1 CDS SAR0063 NC_002952.2 68800 69846 R Poor database matches. Similar to an internal region of Plasmodium falciparum exported serine/threonine protein kinase FesT TR:Q94658 (EMBL:U40232) (2510 aa) fasta scores: E(): 0.021, 23.416% id in 363 aa. Previously sequenced as Staphylococcus aureus hypothetical protein Orf N029 TR:Q9KX84 (EMBL:D86934) (348 aa) fasta scores: E(): 2.5e-118, 100.000% id in 348 aa; hypothetical protein complement(68800..69846) Staphylococcus aureus subsp. aureus MRSA252 2860475 YP_039535.1 CDS SAR0066 NC_002952.2 70924 71238 R Similar to Bacillus anthracis similar IS1627s1 element OrfA TR:Q57266 (EMBL:U30714) (106 aa) fasta scores: E(): 3.2e-18, 51.456% id in 103 aa, and to Marinococcus halophilus transposase TR:O06062 (EMBL:U66614) (110 aa) fasta scores: E(): 9.3e-13, 42.000% id in 100 aa; transposase complement(70924..71238) Staphylococcus aureus subsp. aureus MRSA252 2860477 YP_039536.1 CDS kdpE NC_002952.2 73397 74092 R Two-component regulatory system family, response regulator protein. Similar to Escherichia coli kdp operon transcriptional regulatory protein KdpE SW:KDPE_ECOLI (P21866) (225 aa) fasta scores: E(): 2.7e-28, 41.593% id in 226 aa. Previously sequenced as Staphylococcus aureus kdp operon transcriptional regulatory protein KdpE TR:Q9XBA2 (EMBL:D86934) (231 aa) fasta scores: E(): 5.5e-88, 100.000% id in 231 aa. Similar to SAR2167, 61.233% identity (61.778% ungapped) in 227 aa overlap; response regulator protein complement(73397..74092) Staphylococcus aureus subsp. aureus MRSA252 2859684 YP_039537.1 CDS SAR0069 NC_002952.2 74067 76787 R Two-component regulatory system family, sensor kinase. Similar to Clostridium acetobutylicum histidine kinase sensor protein KdpD SW:KDPD_CLOAB (P94608) (900 aa) fasta scores: E(): 1.2e-75, 29.538% id in 887 aa, and to Rhizobium loti two-component sensor KdpD TR:BAB50088 (EMBL:AP003001) (907 aa) fasta scores: E(): 3.5e-70, 28.699% id in 899 aa. Similar to SAR2166, 58.142% identity (58.613% ungapped) in 872 aa overlap; sensor kinase complement(74067..76787) Staphylococcus aureus subsp. aureus MRSA252 2860479 YP_039538.1 CDS SAR0070 NC_002952.2 77004 78680 D catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 77004..78680 Staphylococcus aureus subsp. aureus MRSA252 2860480 YP_039539.1 CDS SAR0071 NC_002952.2 78699 80720 D one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 78699..80720 Staphylococcus aureus subsp. aureus MRSA252 2860481 YP_039540.1 CDS SAR0074 NC_002952.2 81837 82706 R Poor database matches. Similar to the C-terminal region of Staphylococcus aureus hypothetical protein Orf N031 TR:Q9KX82 (EMBL:D86934) (597 aa) fasta scores: E(): 4.4e-48, 49.823% id in 283 aa. Similar to C-terminal region of SAR0061, 50.530% identity (51.254% ungapped) in 283 aa overlap. Possible C-terminal region of a nonsense mutated protein; hypothetical protein complement(81837..82706) Staphylococcus aureus subsp. aureus MRSA252 2860483 YP_039541.1 CDS SAR0075 NC_002952.2 82716 83612 R Poor database matches. Similar to the N-terminal region of Staphylococcus aureus hypothetical protein Orf N031 sa0059 TR:Q9KX82 (EMBL:D86934) (597 aa) fasta scores: E(): 2.1e-70, 60.068% id in 293 aa. Similar to N-terminal region of SAR0061, 60.068% identity (60.690% ungapped) in 293 aa overlap. Possible N-terminal region of a nonsense mutated protein; hypothetical protein complement(82716..83612) Staphylococcus aureus subsp. aureus MRSA252 2860484 YP_039542.1 CDS SAR0075a NC_002952.2 83654 83779 D Doubtful CDS. No significant database hits; hypothetical protein 83654..83779 Staphylococcus aureus subsp. aureus MRSA252 2860485 YP_039543.1 CDS SAR0076 NC_002952.2 83812 84249 R Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein Orf N009 TR:Q9KX87 (EMBL:D86934) (124 aa) fasta scores: E(): 3.8e-45, 100.000% id in 124 aa CDS is extended at the N-terminus in comparison to the previously sequenced protein. Possible alternative translational start site; hypothetical protein complement(83812..84249) Staphylococcus aureus subsp. aureus MRSA252 2860486 YP_039544.1 CDS SAR0077 NC_002952.2 84354 84641 R Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein Orf N008 TR:Q9KX88 (EMBL:D86934) (95 aa) fasta scores: E(): 2.8e-37, 98.947% id in 95 aa; hypothetical protein complement(84354..84641) Staphylococcus aureus subsp. aureus MRSA252 2860487 YP_039545.1 CDS SAR0078 NC_002952.2 84731 85357 R Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein Orf N007 TR:Q9KX89 (EMBL:D86934) (208 aa) fasta scores: E(): 1.1e-78, 100.000% id in 208 aa; hypothetical protein complement(84731..85357) Staphylococcus aureus subsp. aureus MRSA252 2860488 YP_039546.1 CDS SAR0079 NC_002952.2 85472 86980 D Previously sequenced as Staphylococcus aureus hypothetical protein TR:Q9XBB4 (EMBL:D86934) (502 aa) fasta scores: E(): 9e-192, 99.801% id in 502 aa. Similar to Lactococcus lactis serine/threonine protein kinase PknB TR:Q9CEF5 (EMBL:AE006418) (627 aa) fasta scores: E(): 2.1e-13, 28.527% id in 319 aa. C-terminus is similar to SAR0083, 50.000% identity (50.000% ungapped) in 52 aa overlap; protein kinase 85472..86980 Staphylococcus aureus subsp. aureus MRSA252 2860489 YP_039547.1 CDS SAR0080 NC_002952.2 87145 89265 D No significant database matches to the full length CDS. Similar to internal regions of Saccharomyces cerevisiae intracellular protein transport protein Uso1 SW:USO1_YEAST (P25386) (1790 aa) fasta scores: E(): 6.7e-06, 21.105% id in 706 aa, and to Plasmodium chabaudi repeat organellar protein TR:Q25662 (EMBL:U43145) (1939 aa) fasta scores: E(): 0.00059, 23.381% id in 556 aa; hypothetical protein 87145..89265 Staphylococcus aureus subsp. aureus MRSA252 2860490 YP_039548.1 CDS SAR0081 NC_002952.2 89496 89795 D Similar to Bacillus halodurans transposase TR:Q9JWP9 (EMBL:AP001518) (94 aa) fasta scores: E(): 7e-19, 62.637% id in 91 aa, and to Enterococcus faecium transposase TR:O69430 (EMBL:AJ223633) (96 aa) fasta scores: E(): 4.2e-18, 63.736% id in 91 aa; transposase 89496..89795 Staphylococcus aureus subsp. aureus MRSA252 2860491 YP_039549.1 CDS SAR0082 NC_002952.2 89837 90643 D Similar to Bacillus halodurans transposase TR:Q9JWR5 (EMBL:AP001518) (261 aa) fasta scores: E(): 2e-49, 52.453% id in 265 aa, and to Enterococcus faecium transposase TR:O69429 (EMBL:AJ223633) (282 aa) fasta scores: E(): 1.9e-45, 53.252% id in 246 aa; transposase 89837..90643 Staphylococcus aureus subsp. aureus MRSA252 2860492 YP_039550.1 CDS SAR0084 NC_002952.2 90831 91346 D Poor database matches. Previously sequenced as Staphylococcus aureus hypothetical protein TR:BAB47138 (EMBL:AB047239) (171 aa) fasta scores: E(): 4.7e-63, 100.000% id in 171 aa; hypothetical protein 90831..91346 Staphylococcus aureus subsp. aureus MRSA252 2860494 YP_039551.1 CDS SAR0085 NC_002952.2 91351 92298 R Identical to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 2.6e-127, 100.000% id in 315 aa, and similar to Bacillus halodurans transposase BH3950 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 2.9e-71, 58.413% id in 315 aa; transposase complement(91351..92298) Staphylococcus aureus subsp. aureus MRSA252 2860495 YP_039552.1 CDS SAR0086 NC_002952.2 92484 92858 D Poor database matches. N-terminal region is identical to Staphylococcus aureus hypothetical protein TR:BAB47137 (EMBL:AB047239) (82 aa) fasta scores: E(): 8.8e-27, 100.000% id in 82 aa. Similar to internal region of Saccharomyces cerevisiae hypothetical protein O5254 SW:YO7T_YEAST (Q08647) (676 aa) fasta scores: E(): 7, 31.000% id in 100 aa; hypothetical protein 92484..92858 Staphylococcus aureus subsp. aureus MRSA252 2860496 YP_039553.1 CDS SAR0087 NC_002952.2 93145 94848 D C-terminal region is similar to the C-terminus of Escherichia coli 5-methylcytosine-specific restriction enzyme B McrB SW:MCRB_ECOLI (P15005) (459 aa) fasta scores: E(): 6.8e-41, 47.284% id in 313 aa, and to an internal region of Campylobacter jejuni endonuclease CJ0139 TR:Q9PIY8 (EMBL:AL139074) (783 aa) fasta scores: E(): 7.2e-13, 26.962% id in 586 aa; restriction enzyme 93145..94848 Staphylococcus aureus subsp. aureus MRSA252 2860497 YP_039554.1 CDS SAR0088 NC_002952.2 94841 95881 D McrC protein together with McrB forms the McrBC restriction system; recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines); appears to act against 5-methylcytosine preceded by a purine residue; MrcC modulates the specificty of McrB and has DNA cleavage activity; 5-methylcytosine-specific restriction enzyme subunit McrC 94841..95881 Staphylococcus aureus subsp. aureus MRSA252 2860498 YP_039555.1 CDS SAR0089 NC_002952.2 96110 96208 D hypothetical protein 96110..96208 Staphylococcus aureus subsp. aureus MRSA252 2859710 YP_039556.1 CDS SAR0090 NC_002952.2 96312 96470 D hypothetical protein 96312..96470 Staphylococcus aureus subsp. aureus MRSA252 2859711 YP_039557.1 CDS SAR0091 NC_002952.2 96778 96909 R Similar to C-terminal regions of Mycobacterium tuberculosis insertion sequence IS1534 protein IstB TR:AAK48099 (EMBL:AE007172) (248 aa) fasta scores: E(): 0.0017, 46.875% id in 32 aa, and to Escherichia coli insertion sequence IS21 ATP-binding protein IstB SW:ISTB_ECOLI (P15026) (265 aa) fasta scores: E(): 0.0062, 44.118% id in 34 aa. Probable gene remnant; insertion sequence protein complement(96778..96909) Staphylococcus aureus subsp. aureus MRSA252 2859712 YP_039558.1 CDS SAR0092 NC_002952.2 97309 98280 R Similar to Arthrobacter keyseri oxalomesaconate hydratase PcmD TR:Q9AGL5 (EMBL:AF331043) (342 aa) fasta scores: E(): 5e-05, 23.607% id in 305 aa, and to Synechocystis sp hypothetical protein SLR0619 TR:Q55861 (EMBL:D64004) (348 aa) fasta scores: E(): 5.6e-12, 25.157% id in 318 aa; hydratase complement(97309..98280) Staphylococcus aureus subsp. aureus MRSA252 2859713 YP_039559.1 CDS SAR0093 NC_002952.2 98333 98704 R Poor database matches. N-terminal region is similar to Staphylococcus carnosus hypothetical protein TR:O54485 (EMBL:U96107) (61 aa) fasta scores: E(): 0.005, 36.066% id in 61 aa; hypothetical protein complement(98333..98704) Staphylococcus aureus subsp. aureus MRSA252 2859714 YP_039560.1 CDS SAR0094 NC_002952.2 98724 100085 R Similar to Bacillus subtilis homologue of possible multidrug resistance protein YcnB TR:P94422 (EMBL:D50453) (472 aa) fasta scores: E(): 2.7e-75, 48.444% id in 450 aa, and to Corynebacterium glutamicum possible lincomycin resistance protein LmrB TR:Q9L6D2 (EMBL:AF237667) (481 aa) fasta scores: E(): 1.1e-52, 36.564% id in 454 aa; transporter protein complement(98724..100085) Staphylococcus aureus subsp. aureus MRSA252 2859715 YP_039561.1 CDS SAR0097 NC_002952.2 101081 101656 D Similar to Vibrio cholerae hemagglutinin/protease regulatory protein HapR TR:O30343 (EMBL:AF000716) (203 aa) fasta scores: E(): 0.24, 23.858% id in 197 aa, and to Pasteurella multocida hypothetical protein PM1155 TR:Q9CLQ9 (EMBL:AE006156) (199 aa) fasta scores: E(): 0.028, 23.280% id in 189 aa; DNA-binding protein 101081..101656 Staphylococcus aureus subsp. aureus MRSA252 2859717 YP_039562.1 CDS SAR0098 NC_002952.2 102126 102599 D Similar to Bacillus subtilis hypothetical protein YxbD SW:YXBD_BACSU (P46328) (159 aa) fasta scores: E(): 4.6e-16, 43.046% id in 151 aa, and to Bacillus subtilis hypothetical protein YdhI SW:YDHI_BACSU (O05501) (160 aa) fasta scores: E(): 4e-16, 40.132% id in 152 aa; acetyltransferase (GNAT) family protein 102126..102599 Staphylococcus aureus subsp. aureus MRSA252 2859718 YP_039563.1 CDS SAR0099 NC_002952.2 102706 103692 R Similar to Bacillus subtilis hypothetical protein YfjN TR:O31546 (EMBL:Z99108) (325 aa) fasta scores: E(): 1.2e-101, 75.385% id in 325 aa, and to Borrelia burgdorferi histidine phosphokinase/phophatase BB0737 TR:O51679 (EMBL:AE001173) (335 aa) fasta scores: E(): 1.2e-31, 36.677% id in 319 aa; hypothetical protein complement(102706..103692) Staphylococcus aureus subsp. aureus MRSA252 2859719 YP_039564.1 CDS SAR0100 NC_002952.2 104041 104202 D Similar to internal regions of Sulfolobus solfataricus cobalamin biosynthesis protein B CbiB TR:AAK43329 (EMBL:AE006912) (305 aa) fasta scores: E(): 1.9, 30.612% id in 49 aa, and Methanococcus jannaschii hypothetical protein MJ0139 SW:Y139_METJA (Q57603) (209 aa) fasta scores: E(): 2.4, 35.417% id in 48 aa; hypothetical protein 104041..104202 Staphylococcus aureus subsp. aureus MRSA252 2859720 YP_039565.1 CDS SAR0101 NC_002952.2 104251 104547 D Poor database matches. N-terminal region is similar to the N-terminus of Spirochaeta aurantia hypothetical protein SW:YTR3_SPIAU (P22043) (115 aa) fasta scores: E(): 1.5e-05, 35.366% id in 82 aa; hypothetical protein 104251..104547 Staphylococcus aureus subsp. aureus MRSA252 2859721 YP_039566.1 CDS SAR0102 NC_002952.2 104746 105357 D Poor database matches. Similar to internal region of Sulfolobus solfataricus multidrug resistance related protein SSO0548 TR:AAK40865 (EMBL:AE006685) (393 aa) fasta scores: E(): 1.8, 26.066% id in 211 aa, and to C-terminus of Coxiella burnetii cell division protein FtsW TR:Q9XCY0 (EMBL:AF123260) (372 aa) fasta scores: E(): 4.5, 22.872% id in 188 aa; hypothetical protein 104746..105357 Staphylococcus aureus subsp. aureus MRSA252 2859064 YP_039567.1 CDS SAR0103 NC_002952.2 105625 108777 D Internal region is similar to an internal region of Plasmodium falciparum hypothetical protein PFB0765W TR:O96246 (EMBL:AE001417) (980 aa) fasta scores: E(): 0.052, 23.104% id in 567 aa, and to N-terminal region of Sulfolobus solfataricus purine NTPase SSO2249 TR:AAK42417 (EMBL:AE006829) (864 aa) fasta scores: E(): 0.068, 23.700% id in 654 aa. Contains coiled-coiled domain, residues 621 to 644; hypothetical protein 105625..108777 Staphylococcus aureus subsp. aureus MRSA252 2860806 YP_039568.1 CDS SAR0104 NC_002952.2 108860 109342 D hypothetical protein 108860..109342 Staphylococcus aureus subsp. aureus MRSA252 2860807 YP_039569.1 CDS plc NC_002952.2 109547 110533 D Similar to Staphylococcus aureus 1-phosphatidylinositol phosphodiesterase precursor Plc SW:PLC_STAAU (P45723) (311 aa) fasta scores: E(): 4.6e-114, 95.833% id in 312 aa, and to Bacillus cereus 1-phosphatidylinositol phosphodiesterase precursor SW:PLC_BACCE (P14262) (329 aa) fasta scores: E(): 5.4e-22, 38.650% id in 326 aa; 1-phosphatidylinositol phosphodiesterase 109547..110533 Staphylococcus aureus subsp. aureus MRSA252 2859908 YP_039570.1 CDS SAR0106 NC_002952.2 110754 111524 D No database matches. Similar to several Staphylococcus aureus CDSs, SAR2570, 63.320% identity (64.314% ungapped) in 259 aa overlap, SAR0444, 63.118% identity (65.613% ungapped) in 263 aa overlap, SAR2573, 59.846% identity (61.265% ungapped) in 259 aa overlap and SAR0445, 50.000% identity (53.571% ungapped) in 270 aa overlap; lipoprotein 110754..111524 Staphylococcus aureus subsp. aureus MRSA252 2860808 YP_039571.1 CDS SAR0107 NC_002952.2 111618 113855 D No significant database matches to the full length CDS. N-terminal region is similar to Erwinia chrysanthemi arabinose operon regulatory protein AraC SW:ARAC_ERWCH (P07642) (310 aa) fasta scores: E(): 1.4e-07, 23.755% id in 261 aa, and Bacillus subtilis hypothetical protein YbfI TR:O31449 (EMBL:Z99105) (275 aa) fasta scores: E(): 1.6e-12, 29.707% id in 239 aa; regulatory protein 111618..113855 Staphylococcus aureus subsp. aureus MRSA252 2860809 YP_039572.1 CDS SAR0108 NC_002952.2 114006 115184 D Similar to Lactococcus lactis aminoacylase Amd1 TR:Q9L9P4 (EMBL:AF168363) (398 aa) fasta scores: E(): 8.3e-79, 53.368% id in 386 aa, and to Bacillus halodurans N-acyl-L-amino acid amidohydrolase BH1613 TR:Q9KCF8 (EMBL:AP001512) (404 aa) fasta scores: E(): 3.7e-62, 45.153% id in 392 aa; peptidase 114006..115184 Staphylococcus aureus subsp. aureus MRSA252 2860810 YP_039573.1 CDS SAR0109 NC_002952.2 115186 116574 D Similar to Streptomyces virginiae virginiamycin S resistance protein VarS TR:Q9XE01 (EMBL:AB019519) (518 aa) fasta scores: E(): 3.6e-23, 26.957% id in 460 aa, and to Streptomyces coelicolor transmembrane efflux protein SCH10.26C TR:Q9X8R5 (EMBL:AL049754) (484 aa) fasta scores: E(): 5.6e-24, 27.115% id in 461 aa. Similar to SAR1448, 71.082% identity (71.082% ungapped) in 453 aa overlap and SAR2534, 59.913% identity (60.706% ungapped) in 459 aa overlap; transporter protein 115186..116574 Staphylococcus aureus subsp. aureus MRSA252 2860811 YP_039574.1 CDS SAR0110 NC_002952.2 117060 118727 R Similar to Bacillus halodurans hypothetical protein BH1407 TR:Q9KD12 (EMBL:AP001511) (543 aa) fasta scores: E(): 6.4e-87, 48.339% id in 542 aa, and to Streptococcus pyogenes hypothetical protein SPY1695 TR:Q99YH9 (EMBL:AE006599) (543 aa) fasta scores: E(): 1.2e-74, 43.438% id in 541 aa; Na+/Pi-cotransporter protein complement(117060..118727) Staphylococcus aureus subsp. aureus MRSA252 2860812 YP_039575.1 CDS SAR0111 NC_002952.2 119046 120821 R in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever; myosin-cross-reactive antigen complement(119046..120821) Staphylococcus aureus subsp. aureus MRSA252 2860813 YP_039576.1 CDS SAR0112 NC_002952.2 121172 121645 D Poor database matches. Similar to Archaeoglobus fulgidus hypothetical protein AF0163 TR:O30074 (EMBL:AE001095) (183 aa) fasta scores: E(): 0.16, 27.333% id in 150 aa, and to Mycoplasma pulmonis hypothetical protein TR:CAC13365 (EMBL:AL445563) (167 aa) fasta scores: E(): 3.5, 27.481% id in 131 aa; hypothetical protein 121172..121645 Staphylococcus aureus subsp. aureus MRSA252 2860814 YP_039577.1 CDS lldP1 NC_002952.2 121907 123499 D Similar to Escherichia coli L-lactate permease LldP SW:LLDP_ECOLI (P33231) (551 aa) fasta scores: E(): 1.2e-49, 43.414% id in 539 aa, and to Bacillus halodurans L-lactate permease LctP TR:Q9K5Z9 (EMBL:AP001520) (524 aa) fasta scores: E(): 2.3e-115, 59.322% id in 531 aa. Similar to SAR2455, 65.977% identity (66.352% ungapped) in 532 aa overlap; L-lactate permease 1 121907..123499 Staphylococcus aureus subsp. aureus MRSA252 2859806 YP_039578.1 CDS spa NC_002952.2 123828 125378 R Previously sequenced as Staphylococcus aureus immunoglobulin G binding protein A precursor Spa SW:SPA2_STAAU (P38507) (508 aa) fasta scores: E(): 1.6e-150, 98.062% id in 516 aa. Similar to Staphylococcus carnosus human serum albumin-binding cell surface precursor PPMABPXM TR:Q53833 (EMBL:U15516) (666 aa) fasta scores: E(): 2.6e-53, 50.484% id in 517 aa. Probable LPXTG-sorted surface protein; immunoglobulin G binding protein A precursor complement(123828..125378) Staphylococcus aureus subsp. aureus MRSA252 2859152 YP_039579.1 CDS SAR0115 NC_002952.2 125799 126551 R C-terminus is similar to Staphylococcus aureus staphylococcal accessory regulator A SarA TR:Q53777 (EMBL:U46541) (113 aa) fasta scores: E(): 1.1e-07, 35.849% id in 106 aa. Full length CDS is similar to Staphylococcus aureus Rot-like protein, agr locus activator, Rlp TR:Q9EZK4 (EMBL:AF288788) (247 aa) fasta scores: E(): 1.9e-29, 38.683% id in 243 aa; regulatory protein complement(125799..126551) Staphylococcus aureus subsp. aureus MRSA252 2860815 YP_039580.1 CDS sirC NC_002952.2 126920 127918 R Similar to Erwinia chrysanthemi achromobactin ABC transporter permease CbrC SW:CBRC_ERWCH (Q47086) (349 aa) fasta scores: E(): 3.1e-36, 37.309% id in 327 aa. Previously sequenced as Staphylococcus aureus siderophore transport protein SirC TR:O87493 (EMBL:AF079518) (332 aa) fasta scores: E(): 7.1e-108, 97.289% id in 332 aa; siderophore ABC transporter permease complement(126920..127918) Staphylococcus aureus subsp. aureus MRSA252 2859147 YP_039581.1 CDS sirB NC_002952.2 127915 128910 R Similar to Erwinia chrysanthemi achromobactin ABC transporter permease CbrB SW:CBRB_ERWCH (Q47085) (340 aa) fasta scores: E(): 1.5e-44, 43.077% id in 325 aa. Previously sequenced as Staphylococcus aureus siderophore transport protein SirB TR:O87492 (EMBL:AF079518) (331 aa) fasta scores: E(): 5.9e-109, 99.396% id in 331 aa; siderophore ABC transporter permease complement(127915..128910) Staphylococcus aureus subsp. aureus MRSA252 2859146 YP_039582.1 CDS sirA NC_002952.2 128926 129918 R Previously sequenced as Staphylococcus aureus iron-regulated lipoprotein SirA TR:O87491 (EMBL:AF079518) (330 aa) fasta scores: E(): 6.5e-114, 99.697% id in 330 aa. Similar to Erwinia chrysanthemi achromobactin-binding periplasmic protein precursor CbrA SW:CBRA_ERWCH (Q47084) (305 aa) fasta scores: E(): 3.2e-28, 36.431% id in 269 aa; lipoprotein complement(128926..129918) Staphylococcus aureus subsp. aureus MRSA252 2859145 YP_039583.1 CDS SAR0119 NC_002952.2 130149 131129 D Similar to Alcaligenes eutrophus cysteine synthase CysM SW:CYSM_ALCEU (Q44004) (339 aa) fasta scores: E(): 2.3e-48, 45.231% id in 325 aa, and to Helicobacter pylori J99 cysteine synthase CysM SW:CYSM_HELPJ (Q9ZMW6) (305 aa) fasta scores: E(): 4e-30, 34.098% id in 305 aa; pyridoxal-phosphate dependent protein 130149..131129 Staphylococcus aureus subsp. aureus MRSA252 2860816 YP_039584.1 CDS SAR0120 NC_002952.2 131126 132136 D Similar to Rhizobium meliloti ornithine cyclodeaminase Ocd SW:OCD_RHIME (P33728) (320 aa) fasta scores: E(): 3e-14, 22.727% id in 330 aa, and to Archaeoglobus fulgidus ornithine cyclodeaminase AF1665 TR:O28608 (EMBL:AE000988) (322 aa) fasta scores: E(): 2.5e-25, 31.953% id in 338 aa; ornithine cyclodeaminase 131126..132136 Staphylococcus aureus subsp. aureus MRSA252 2860817 YP_039585.1 CDS SAR0121 NC_002952.2 132157 133911 D C-terminal region is similar to C-terminus of Escherichia coli aerobactin siderophore biosynthesis protein IucC SW:IUCC_ECOLI (Q47318) (580 aa) fasta scores: E(): 6.1e-10, 25.926% id in 459 aa. Full length CDS is similar to Bacillus halodurans hypothetical protein BH2618 TR:Q9K9M7 (EMBL:AP001516) (601 aa) fasta scores: E(): 3.1e-13, 22.165% id in 582 aa; siderophore biosynthesis protein 132157..133911 Staphylococcus aureus subsp. aureus MRSA252 2860818 YP_039586.1 CDS SAR0122 NC_002952.2 133904 135160 D Similar to Streptococcus pneumoniae multi-drug resistance efflux pump PmrA TR:Q9ZEX9 (EMBL:AJ007367) (399 aa) fasta scores: E(): 3.4e-23, 25.123% id in 406 aa, and to Lactococcus lactis multidrug resistance efflux pump PmrB TR:Q9CJ75 (EMBL:AE006250) (398 aa) fasta scores: E(): 6e-29, 26.873% id in 387 aa; transport protein 133904..135160 Staphylococcus aureus subsp. aureus MRSA252 2860819 YP_039587.1 CDS SAR0123 NC_002952.2 135150 136886 D Similar to Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhsC SW:RHSC_RHIME (Q9Z3R0) (585 aa) fasta scores: E(): 2.6e-31, 26.723% id in 595 aa, and to Escherichia coli aerobactin siderophore biosynthesis protein IucA SW:IUCA_ECOLI (Q47316) (575 aa) fasta scores: E(): 3.4e-23, 23.639% id in 588 aa; siderophore biosynthesis protein 135150..136886 Staphylococcus aureus subsp. aureus MRSA252 2860820 YP_039588.1 CDS SAR0124 NC_002952.2 136867 138645 D Similar to Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhsF SW:RHSF_RHIME (Q9Z3Q7) (601 aa) fasta scores: E(): 3.5e-43, 28.571% id in 560 aa, and to Escherichia coli aerobactin siderophore biosynthesis protein IucC SW:IUCC_ECOLI (Q47318) (580 aa) fasta scores: E(): 1.1e-28, 24.912% id in 566 aa; siderophore biosynthesis protein 136867..138645 Staphylococcus aureus subsp. aureus MRSA252 2860821 YP_039589.1 CDS SAR0125 NC_002952.2 138620 139396 D Similar to Escherichia coli 5-keto-4-deoxy-D-glucarate aldolase GarL SW:GARL_ECOLI (P23522) (256 aa) fasta scores: E(): 3.2e-17, 29.832% id in 238 aa, and to Rhizobium loti 4-hydroxy-2-oxovalerate aldolase MLL5426 TR:BAB51880 (EMBL:AP003006) (264 aa) fasta scores: E(): 1.5e-21, 34.956% id in 226 aa; aldolase 138620..139396 Staphylococcus aureus subsp. aureus MRSA252 2860822 YP_039590.1 CDS SAR0126 NC_002952.2 139396 140598 D Similar to Pseudomonas fluorescens diaminopimelate decarboxylase LysA SW:DCDA_PSEFL (O05321) (416 aa) fasta scores: E(): 5.1e-16, 27.671% id in 365 aa, and to Bacillus circulans butirosin-biosynthetic gene cluster protein BtrK TR:Q9F1Z3 (EMBL:AB033991) (428 aa) fasta scores: E(): 4.8e-30, 31.152% id in 382 aa; pyridoxal-dependent decarboxylase 139396..140598 Staphylococcus aureus subsp. aureus MRSA252 2860302 YP_039591.1 CDS SAR0127 NC_002952.2 140602 141366 D hypothetical protein 140602..141366 Staphylococcus aureus subsp. aureus MRSA252 2860303 YP_039592.1 CDS SAR0128 NC_002952.2 141562 142188 D hypothetical protein 141562..142188 Staphylococcus aureus subsp. aureus MRSA252 2860304 YP_039593.1 CDS SAR0129 NC_002952.2 142399 143175 D Similar to Lactococcus lactis diacetyl-acetoin reductase Dar TR:Q9RLV7 (EMBL:AJ012388) (256 aa) fasta scores: E(): 2.4e-38, 48.221% id in 253 aa, and to Klebsiella pneumoniae acetoin BudC SW:BUDC_KLEPN (Q48436) (256 aa) fasta scores: E(): 4e-53, 58.893% id in 253 aa; acetoin reductase 142399..143175 Staphylococcus aureus subsp. aureus MRSA252 2860305 YP_039594.1 CDS SAR0130a NC_002952.2 143224 143337 R Doubtful CDS. No significant database hits; hypothetical protein complement(143224..143337) Staphylococcus aureus subsp. aureus MRSA252 2860307 YP_039595.1 CDS SAR0130 NC_002952.2 143519 144490 D Similar to Salmonella typhi Vi antigen polysaccharide biosynthesis protein VipB SW:VIPB_SALTI (Q04973) (348 aa) fasta scores: E(): 1.3e-27, 34.756% id in 328 aa, and to Lactococcus lactis UDP-glucose 4-epimerase YcbD TR:Q9CIZ5 (EMBL:AE006259) (313 aa) fasta scores: E(): 9.7e-48, 41.967% id in 305 aa; NAD dependent epimerase/dehydratase 143519..144490 Staphylococcus aureus subsp. aureus MRSA252 2860306 YP_039596.1 CDS SAR0131 NC_002952.2 144453 145142 D Similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5M TR:P95706 (EMBL:U81973) (185 aa) fasta scores: E(): 1.7e-21, 41.622% id in 185 aa, and to Bacillus halodurans teichuronic acid biosynthesis protein TuaA TR:Q9K6S6 (EMBL:AP001519) (205 aa) fasta scores: E(): 1.2e-24, 47.531% id in 162 aa; sugar transferase 144453..145142 Staphylococcus aureus subsp. aureus MRSA252 2860308 YP_039597.1 CDS SAR0132 NC_002952.2 145352 146518 D Similar to Streptococcus pneumoniae galactosyl transferase Cap8H TR:Q9X9A5 (EMBL:AJ239004) (354 aa) fasta scores: E(): 3.2e-08, 24.510% id in 306 aa, and to Thermotoga maritima lipopolysaccharide biosynthesis protein TM0622 TR:Q9WZ90 (EMBL:AE001736) (388 aa) fasta scores: E(): 1.9e-10, 25.000% id in 396 aa; galactosyl transferase 145352..146518 Staphylococcus aureus subsp. aureus MRSA252 2860309 YP_039598.1 CDS SAR0133 NC_002952.2 146499 147737 D Similar to Streptococcus pneumoniae type 2 capsular polysaccharide biosynthesis protein Cps2H TR:Q9ZII1 (EMBL:AF026471) (387 aa) fasta scores: E(): 0.00016, 23.558% id in 416 aa, and to Actinobacillus actinomycetemcomitans (Haemophilus actinomycetemcomitans) serotype d-specific polysaccharide biosynthetesis protein TR:Q9JRS0 (EMBL:AB041266) (431 aa) fasta scores: E(): 0.0017, 21.362% id in 426 aa; hypothetical protein 146499..147737 Staphylococcus aureus subsp. aureus MRSA252 2860310 YP_039599.1 CDS SAR0134 NC_002952.2 147727 149157 D Similar to Yersinia enterocolitica lipopolysaccharide O-unit flippase TrsA TR:Q56913 (EMBL:Z47767) (418 aa) fasta scores: E(): 7.6e-18, 24.257% id in 404 aa, and to Streptococcus thermophilus hypothetical protein EpsI TR:AAK61904 (EMBL:AF373595) (471 aa) fasta scores: E(): 5.2e-46, 30.917% id in 469 aa; polysaccharide biosynthesis protein 147727..149157 Staphylococcus aureus subsp. aureus MRSA252 2860311 YP_039600.1 CDS sodM NC_002952.2 149425 150024 D Previously sequenced as Staphylococcus aureus superoxide dismutase SodM TR:Q9EZZ2 (EMBL:AF273269) (187 aa) fasta scores: E(): 6.2e-77, 100.000% id in 187 aa. Similar to Staphylococcus xylosus superoxide dismutase Sod TR:Q9K4V3 (EMBL:AJ276960) (199 aa) fasta scores: E(): 2.5e-65, 76.382% id in 199 aa. Similar to SAR1630, 74.874% identity (74.874% ungapped) in 199 aa overlap; superoxide dismutase 149425..150024 Staphylococcus aureus subsp. aureus MRSA252 2859151 YP_039601.1 CDS sasD NC_002952.2 150393 151058 D No significant database matches. Possible LPXAG-sorted surface protein; surface anchored protein 150393..151058 Staphylococcus aureus subsp. aureus MRSA252 2859121 YP_039602.1 CDS SAR0137 NC_002952.2 151160 151900 R Similar to Pseudomonas fluorescens transcriptional repressor of the trehalose operon TreR TR:Q9F8X4 (EMBL:AF229829) (234 aa) fasta scores: E(): 7.1e-05, 26.267% id in 217 aa, and to Streptococcus pyogenes transcriptional regulator SPY1870 TR:Q99Y48 (EMBL:AE006612) (247 aa) fasta scores: E(): 8.3e-19, 28.879% id in 232 aa; GntR family transcriptional regulator complement(151160..151900) Staphylococcus aureus subsp. aureus MRSA252 2860312 YP_039603.1 CDS deoD1 NC_002952.2 152151 152858 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 152151..152858 Staphylococcus aureus subsp. aureus MRSA252 2859589 YP_039604.1 CDS SAR0139 NC_002952.2 152865 154217 D Similar to Bacillus subtilis tetracycline resistance protein TetB SW:TCRB_BACSU (P23054) (458 aa) fasta scores: E(): 2.2e-28, 26.201% id in 458 aa, and to Staphylococcus hyicus tetracycline resistance protein Tet SW:TCR_STAHY (P36890) (458 aa) fasta scores: E(): 6.8e-28, 25.764% id in 458 aa; transporter 152865..154217 Staphylococcus aureus subsp. aureus MRSA252 2860313 YP_039605.1 CDS deoC1 NC_002952.2 154298 154960 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 154298..154960 Staphylococcus aureus subsp. aureus MRSA252 2859268 YP_039606.1 CDS drm NC_002952.2 154988 156166 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 154988..156166 Staphylococcus aureus subsp. aureus MRSA252 2859607 YP_039607.1 CDS SAR0142 NC_002952.2 156297 157112 R Similar to Escherichia coli phosphonates ABC transporter permease PhnE SW:PHNE_ECOLI (P16683) (276 aa) fasta scores: E(): 5.6e-26, 35.341% id in 249 aa, and to Bacillus halodurans phosphonates transporter BH0442 TR:Q9KFN7 (EMBL:AP001508) (267 aa) fasta scores: E(): 8.5e-49, 52.896% id in 259 aa; binding-protein-dependent transport systems membrane component complement(156297..157112) Staphylococcus aureus subsp. aureus MRSA252 2860314 YP_039608.1 CDS SAR0143 NC_002952.2 157109 157909 R Similar to Escherichia coli phosphonates ABC transporter permease PhnE SW:PHNE_ECOLI (P16683) (276 aa) fasta scores: E(): 2.3e-27, 36.032% id in 247 aa, and to Bacillus halodurans phosphonates transport system BH0441 TR:Q9KFN8 (EMBL:AP001508) (263 aa) fasta scores: E(): 1.6e-44, 49.615% id in 260 aa; binding-protein-dependent transport system membrane component complement(157109..157909) Staphylococcus aureus subsp. aureus MRSA252 2860315 YP_039609.1 CDS SAR0144 NC_002952.2 157911 158684 R Similar to Escherichia coli phosphonates transport ATP-binding protein PhnC SW:PHNC_ECOLI (P16677) (262 aa) fasta scores: E(): 2e-30, 43.750% id in 256 aa, and to Bacillus halodurans transporter BH0440 TR:Q9KFN9 (EMBL:AP001508) (257 aa) fasta scores: E(): 4.2e-57, 69.841% id in 252 aa; ABC transporter ATP-binding protein complement(157911..158684) Staphylococcus aureus subsp. aureus MRSA252 2860316 YP_039610.1 CDS SAR0145 NC_002952.2 158898 159854 R Similar to an internal region of Escherichia coli phosphonates-binding periplasmic protein precursor PhnD SW:PHND_ECOLI (P16682) (338 aa) fasta scores: E(): 7.5e-10, 24.101% id in 278 aa. Full length CDS is similar to Bacillus halodurans hypothetical protein BH0439 TR:Q9KFP0 (EMBL:AP001508) (317 aa) fasta scores: E(): 1.4e-55, 54.693% id in 309 aa; lipoprotein complement(158898..159854) Staphylococcus aureus subsp. aureus MRSA252 2860317 YP_039611.1 CDS SAR0146 NC_002952.2 160083 161627 D No significant database matches to the full length CDS. Internal region of CDS is similar to an internal region Arabidopsis thaliana hypothetical protein F4P12_240 TR:Q9LFG5 (EMBL:AL132966) (932 aa) fasta scores: E(): 1, 24.390% id in 328 aa; hypothetical protein 160083..161627 Staphylococcus aureus subsp. aureus MRSA252 2860318 YP_039612.1 CDS SAR0147 NC_002952.2 161678 163213 D Similar to Escherichia coli 2',3'-cyclic-nucleotide 2'-phosphodiesterase CpdB SW:CN16_ECOLI (P08331) (647 aa) fasta scores: E(): 5.4e-09, 25.279% id in 538 aa, and to Lactococcus lactis phosphatase YcjM TR:Q9CIQ3 (EMBL:AE006267) (519 aa) fasta scores: E(): 7.5e-74, 38.477% id in 512 aa; nucleotidase 161678..163213 Staphylococcus aureus subsp. aureus MRSA252 2860319 YP_039613.1 CDS SAR0148 NC_002952.2 163370 164137 D Poor database matches. Similar to Borrelia burgdorferi plasmid hypothetical protein TR:Q44710 (EMBL:U03641) (371 aa) fasta scores: E(): 0.89, 22.222% id in 234 aa; hypothetical protein 163370..164137 Staphylococcus aureus subsp. aureus MRSA252 2860320 YP_039614.1 CDS SAR0149 NC_002952.2 164143 165318 D Poor database matches. Similar to Neisseria meningitidis transcriptional regulator NMB2012 TR:Q9JXJ6 (EMBL:AE002551) (363 aa) fasta scores: E(): 3e-09, 25.714% id in 350 aa, and to Mycobacterium tuberculosis DNA-binding protein MT2073 TR:AAK46351 (EMBL:AE007058) (346 aa) fasta scores: E(): 0.0001, 28.012% id in 332 aa; DNA-binding protein 164143..165318 Staphylococcus aureus subsp. aureus MRSA252 2860321 YP_039615.1 CDS adhE NC_002952.2 165704 168313 D Similar to Escherichia coli aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase, acetaldehyde dehydrogenase and pyruvate-formate-lyase-deactivase] AdhE SW:ADHE_ECOLI (P17547) (890 aa) fasta scores: E(): 3.4e-140, 48.601% id in 858 aa, and to Entamoeba histolytica aldehyde-alcohol dehydrogenase 2 [includes: alcohol dehydrogenase, acetaldehyde dehydrogenase, and pyruvate-formate-lyase-deactivase] Adh2 SW:ADH2_ENTHI (Q24803) (870 aa) fasta scores: E(): 4.8e-170, 52.887% id in 866 aa; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 165704..168313 Staphylococcus aureus subsp. aureus MRSA252 2860979 YP_039616.1 CDS capA NC_002952.2 168658 169326 D Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5A TR:P95695 (EMBL:U81973) (222 aa) fasta scores: E(): 1.3e-72, 99.550% id in 222 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8A TR:P72367 (EMBL:U73374) (222 aa) fasta scores: E(): 5.2e-72, 98.649% id in 222 aa, Similar to SAR2745, 52.489% identity (52.727% ungapped) in 221 aa overlap; capsular polysaccharide synthesis enzyme 168658..169326 Staphylococcus aureus subsp. aureus MRSA252 2861340 YP_039617.1 CDS capB NC_002952.2 169342 170028 D Highly imilar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8B TR:P72368 (EMBL:U73374) (228 aa) fasta scores: E(): 3.8e-77, 96.491% id in 228 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5B TR:P95696 (EMBL:U81973) (228 aa) fasta scores: E(): 1e-76, 95.614% id in 228 aa. Similar to SAR2744, 5.895% identity (56.140% ungapped) in 229 aa overlap; capsular polysaccharide synthesis enzyme 169342..170028 Staphylococcus aureus subsp. aureus MRSA252 2861341 YP_039618.1 CDS capC NC_002952.2 170031 170795 D Highly imilar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8C TR:P72369 (EMBL:U73374) (254 aa) fasta scores: E(): 1.5e-96, 99.213% id in 254 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5C TR:P95697 (EMBL:U81973) (254 aa) fasta scores: E(): 4.2e-96, 98.425% id in 254 aa. Similar to SAR2743, 52.549% identity (53.175% ungapped) in 255 aa overlap; capsular polysaccharide synthesis enzyme 170031..170795 Staphylococcus aureus subsp. aureus MRSA252 2861342 YP_039619.1 CDS capD NC_002952.2 170815 172638 D Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5D TR:P95698 (EMBL:U81973) (607 aa) fasta scores: E(): 1.5e-214, 99.012% id in 607 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8D TR:P72370 (EMBL:U73374) (607 aa) fasta scores: E(): 8.4e-214, 98.682% id in 607 aa; capsular polysaccharide synthesis enzyme 170815..172638 Staphylococcus aureus subsp. aureus MRSA252 2861343 YP_039620.1 CDS capE NC_002952.2 172628 173656 D Identical to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8E TR:P72371 (EMBL:U73374) (342 aa) fasta scores: E(): 4.3e-127, 100.000% id in 342 aa Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5E TR:P95699 (EMBL:U81973) (342 aa) fasta scores: E(): 1e-126, 99.708% id in 342 aa; capsular polysaccharide synthesis enzyme 172628..173656 Staphylococcus aureus subsp. aureus MRSA252 2861344 YP_039621.1 CDS capF NC_002952.2 173669 174778 D Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5F TR:P95700 (EMBL:U81973) (371 aa) fasta scores: E(): 3.6e-143, 99.187% id in 369 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8F TR:P72372 (EMBL:U73374) (371 aa) fasta scores: E(): 4.6e-141, 97.832% id in 369 aa; capsular polysaccharide synthesis enzyme 173669..174778 Staphylococcus aureus subsp. aureus MRSA252 2861345 YP_039622.1 CDS capG NC_002952.2 174782 175906 D Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8G TR:P72373 (EMBL:U73374) (374 aa) fasta scores: E(): 2.2e-139, 99.465% id in 374 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5G TR:P95701 (EMBL:U81973) (374 aa) fasta scores: E(): 9.9e-139, 99.198% id in 374 aa; capsular polysaccharide synthesis enzyme 174782..175906 Staphylococcus aureus subsp. aureus MRSA252 2861346 YP_039623.1 CDS cap8H NC_002952.2 175909 176988 D Similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8H TR:P72374 (EMBL:U73374) (359 aa) fasta scores: E(): 2.4e-129, 93.872% id in 359 aa, and to Streptococcus pneumoniae capsular polysaccharide synthesis enzyme O-antigen translocase WciK TR:Q9AHC9 (EMBL:AF316639) (358 aa) fasta scores: E(): 5.2e-26, 31.319% id in 364 aa; capsular polysaccharide synthesis enzyme 175909..176988 Staphylococcus aureus subsp. aureus MRSA252 2861336 YP_039624.1 CDS cap8I NC_002952.2 176981 178375 D Poor database matches. Similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8I TR:P72375 (EMBL:U73374) (464 aa) fasta scores: E(): 2e-161, 98.060% id in 464 aa; capsular polysaccharide synthesis enzyme 176981..178375 Staphylococcus aureus subsp. aureus MRSA252 2861337 YP_039625.1 CDS cap8J NC_002952.2 178372 178929 D Identical to aureus capsular polysaccharide synthesis enzyme Cap8J TR:P72376 (EMBL:U73374) (185 aa) fasta scores: E(): 7.2e-73, 100.000% id in 185 aa. C_terminal region is similar to the C-terminus of Vibrio cholerae probable galactoside-O-acetyl transferase WblB TR:O87158 (EMBL:AB012957) (161 aa) fasta scores: E(): 4.6e-10, 38.333% id in 120 aa; capsular polysaccharide synthesis enzyme 178372..178929 Staphylococcus aureus subsp. aureus MRSA252 2861338 YP_039626.1 CDS cap8K NC_002952.2 178938 180176 D Similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8K TR:P72377 (EMBL:U73374) (412 aa) fasta scores: E(): 2.9e-128, 97.573% id in 412 aa, and to Pseudomonas aeruginosa protein O-antigen translocase WbpF TR:P72137 (EMBL:U50396) (411 aa) fasta scores: E(): 3.5e-19, 22.850% id in 407 aa; capsular polysaccharide synthesis enzyme 178938..180176 Staphylococcus aureus subsp. aureus MRSA252 2861339 YP_039627.1 CDS capL NC_002952.2 180210 181415 D Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5L TR:P95705 (EMBL:U81973) (401 aa) fasta scores: E(): 1.5e-152, 99.501% id in 401 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8L TR:P72378 (EMBL:U73374) (401 aa) fasta scores: E(): 8.6e-151, 98.005% id in 401 aa; capsular polysaccharide synthesis enzyme 180210..181415 Staphylococcus aureus subsp. aureus MRSA252 2861347 YP_039628.1 CDS capM NC_002952.2 181426 181983 D Similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5M TR:P95706 (EMBL:U81973) (185 aa) fasta scores: E(): 4.5e-69, 99.459% id in 185 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8M TR:P72379 (EMBL:U73374) (185 aa) fasta scores: E(): 6.1e-69, 98.378% id in 185 aa; capsular polysaccharide synthesis enzyme 181426..181983 Staphylococcus aureus subsp. aureus MRSA252 2861348 YP_039629.1 CDS capN NC_002952.2 181983 182870 D Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5N TR:P95707 (EMBL:U81973) (295 aa) fasta scores: E(): 1.7e-110, 98.644% id in 295 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8N TR:P72380 (EMBL:U73374) (295 aa) fasta scores: E(): 1.4e-109, 97.966% id in 295 aa; capsular polysaccharide synthesis enzyme 181983..182870 Staphylococcus aureus subsp. aureus MRSA252 2861349 YP_039630.1 CDS capO NC_002952.2 182924 184186 D Highly imilar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5O TR:P95708 (EMBL:U81973) (420 aa) fasta scores: E(): 3.9e-157, 99.048% id in 420 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8O TR:P72381 (EMBL:U73374) (420 aa) fasta scores: E(): 1.6e-156, 99.048% id in 420 aa; capsular polysaccharide synthesis enzyme 182924..184186 Staphylococcus aureus subsp. aureus MRSA252 2861350 YP_039631.1 CDS capP NC_002952.2 184233 185408 D Highly similar to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap8P TR:P72382 (EMBL:U73374) (391 aa) fasta scores: E(): 2.4e-146, 98.721% id in 391 aa, and to Staphylococcus aureus capsular polysaccharide synthesis enzyme Cap5P TR:P95709 (EMBL:U81973) (391 aa) fasta scores: E(): 2.8e-146, 98.465% id in 391 aa. Similar to SAR2199, 60.372% identity (60.372% ungapped) in 376 aa overlap; capsular polysaccharide synthesis enzyme 184233..185408 Staphylococcus aureus subsp. aureus MRSA252 2861351 YP_039632.1 CDS SAR0167 NC_002952.2 185473 185799 R iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source; heme-degrading monooxygenase IsdI complement(185473..185799) Staphylococcus aureus subsp. aureus MRSA252 2860322 YP_039633.1 CDS SAR0168 NC_002952.2 185806 186189 R Similar to Staphylococcus carnosus hypothetical protein TR:Q9F328 (EMBL:AJ279090) (129 aa) fasta scores: E(): 4.4e-25, 55.118% id in 127 aa, and to Pasteurella multocida hypothetical protein PM0679 TR:Q9CMX2 (EMBL:AE006104) (120 aa) fasta scores: E(): 1.2e-11, 33.333% id in 120 aa; hypothetical protein complement(185806..186189) Staphylococcus aureus subsp. aureus MRSA252 2860323 YP_039634.1 CDS SAR0169 NC_002952.2 186616 188103 D Similar to Vibrio cholerae aldehyde dehydrogenase AldA SW:DHAL_VIBCH (P23240) (506 aa) fasta scores: E(): 7.5e-81, 44.490% id in 490 aa, and to Alteromonas sp aldehyde dehydrogenase OlgA TR:O50609 (EMBL:AB009654) (505 aa) fasta scores: E(): 8.8e-78, 43.035% id in 481 aa; aldehyde dehydrogenase 186616..188103 Staphylococcus aureus subsp. aureus MRSA252 2860324 YP_039635.1 CDS SAR0170 NC_002952.2 188750 189709 D Similar to Alcaligenes sp cation efflux system protein CzcD SW:CZCD_ALCSP (P94178) (316 aa) fasta scores: E(): 6.7e-32, 36.458% id in 288 aa, and to Staphylococcus aureus zinc resistance protein CzrB TR:Q9ZNF5 (EMBL:AB016431) (325 aa) fasta scores: E(): 6.9e-38, 41.237% id in 291 aa; cation efflux system protein 188750..189709 Staphylococcus aureus subsp. aureus MRSA252 2860325 YP_039636.1 CDS SAR0171 NC_002952.2 189771 189974 R hypothetical protein complement(189771..189974) Staphylococcus aureus subsp. aureus MRSA252 2860326 YP_039637.1 CDS SAR0172 NC_002952.2 190154 190666 D Poor database matches. Similar to Synechococcus sp alpha-helical coiled-coil protein SrpF TR:Q9R6V4 (EMBL:AF176824) (175 aa) fasta scores: E(): 1.8e-21, 42.515% id in 167 aa; hypothetical protein 190154..190666 Staphylococcus aureus subsp. aureus MRSA252 2860327 YP_039638.1 CDS SAR0173 NC_002952.2 191008 191748 D Similar to Synechococcus sp nitrate transport ATP-binding protein NrtD SW:NRTD_SYNP7 (P38046) (274 aa) fasta scores: E(): 9.7e-28, 40.343% id in 233 aa, and to Phormidium laminosum ATP binding protein NrtC-Phl TR:Q51882 (EMBL:Z19598) (625 aa) fasta scores: E(): 7.4e-29, 43.154% id in 241 aa; ABC transporter ATP-binding protein 191008..191748 Staphylococcus aureus subsp. aureus MRSA252 2860328 YP_039639.1 CDS SAR0174 NC_002952.2 191762 192736 D Internal region of CDS is similar to internal regions of Escherichia coli taurine-binding periplasmic protein precursor TauA SW:TAUA_ECOLI (Q47537) (320 aa) fasta scores: E(): 0.2, 25.410% id in 244 aa, and Escherichia coli aliphatic sulfonates binding protein precursor SsuA SW:SSUA_ECOLI (P75853) (319 aa) fasta scores: E(): 0.00019, 22.509% id in 271 aa; lipoprotein 191762..192736 Staphylococcus aureus subsp. aureus MRSA252 2860329 YP_039640.1 CDS SAR0175 NC_002952.2 192733 193494 D Similar to Escherichia coli taurine ABC transporter permease TauC SW:TAUC_ECOLI (Q47539) (275 aa) fasta scores: E(): 5.2e-22, 29.084% id in 251 aa, and to Pseudomonas aeruginosa probable permease of ABC transporter PA3443 TR:Q9HYG3 (EMBL:AE004765) (262 aa) fasta scores: E(): 6.8e-28, 34.034% id in 238 aa; ABC transporter permease 192733..193494 Staphylococcus aureus subsp. aureus MRSA252 2860330 YP_039641.1 CDS SAR0176 NC_002952.2 193507 194538 D Similar to Solanum tuberosum isovaleryl-CoA dehydrogenase precursor Ivd1 TR:Q9FS88 (EMBL:AJ278987) (412 aa) fasta scores: E(): 0.14, 19.805% id in 308 aa, and to Neisseria meningitidis acyl-CoA dehydrogenase NMB0994 TR:Q9JZL9 (EMBL:AE002450) (363 aa) fasta scores: E(): 1.2e-22, 30.636% id in 346 aa; hypothetical protein 193507..194538 Staphylococcus aureus subsp. aureus MRSA252 2860331 YP_039642.1 CDS SAR0177 NC_002952.2 194752 195111 D Similar to Bacillus subtilis hypothetical protein YrhF SW:YRHF_BACSU (O05398) (122 aa) fasta scores: E(): 2.4e-11, 36.937% id in 111 aa. C-terminal region is similar to Bacillus halodurans hypothetical protein BH2529 TR:Q9K9W6 (EMBL:AP001515) (82 aa) fasta scores: E(): 2.1e-06, 44.000% id in 75 aa; hypothetical protein 194752..195111 Staphylococcus aureus subsp. aureus MRSA252 2860332 YP_039643.1 CDS SAR0178 NC_002952.2 195186 196310 D Catalyzes the reversible two-electron oxidation of formate to carbon dioxide. It allows the assimilation of carbon dioxide and provides energy for growth through oxidative phosphorylation coupled to the reduction of oxygen, nitrate, sulphate or fumarate; formate dehydrogenase 195186..196310 Staphylococcus aureus subsp. aureus MRSA252 2860333 YP_039644.1 CDS SAR0179 NC_002952.2 196696 197946 D Similar to Lactococcus lactis proton motive force-dependent drug transporter LmrP TR:Q48658 (EMBL:X89779) (408 aa) fasta scores: E(): 2.4e-09, 24.096% id in 415 aa, and to Deinococcus radiodurans integral membrane protein LmrP TR:Q9RZS1 (EMBL:AE001826) (432 aa) fasta scores: E(): 2.2e-27, 27.094% id in 406 aa; transporter protein 196696..197946 Staphylococcus aureus subsp. aureus MRSA252 2860205 YP_039645.1 CDS SAR0180 NC_002952.2 198393 205568 D Similar to the N-terminal region of Bacillus licheniformis bacitracin synthetase 3 BacC SW:BACC_BACLI (O68008) (6359 aa) fasta scores: E(): 2.8e-147, 32.871% id in 2093 aa, and to Bacillus subtilis peptide synthetase PpsD TR:P94459 (EMBL:Z34883) (3603 aa) fasta scores: E(): 4.2e-166, 31.103% id in 2122 aa; non-ribosomal peptide synthetase 198393..205568 Staphylococcus aureus subsp. aureus MRSA252 2860206 YP_039646.1 CDS SAR0181 NC_002952.2 205581 206225 D N-terminus is similar to N-terminal regions of Bacillus subtilis lipopeptide antibiotics iturin A and surfactin biosynthesis protein Lpa-14 SW:LP14_BACSU (P39144) (224 aa) fasta scores: E(): 3e-07, 30.682% id in 176 aa, and Bacillus pumilus surfactin synthesis regulator Psf-1 SW:PSF1_BACPU (P55810) (233 aa) fasta scores: E(): 3.6e-07, 30.508% id in 177 aa; 4'-phosphopantetheinyl transferase 205581..206225 Staphylococcus aureus subsp. aureus MRSA252 2860207 YP_039647.1 CDS SAR0182 NC_002952.2 206554 207048 R Similar to Lactococcus lactis hypothetical protein YreD TR:Q9CEZ2 (EMBL:AE006399) (178 aa) fasta scores: E(): 6.7e-30, 47.771% id in 157 aa, and to Campylobacter jejuni integral membrane protein CJ0014C TR:Q9PJ97 (EMBL:AL139074) (174 aa) fasta scores: E(): 8.7e-24, 42.424% id in 165 aa; hypothetical protein complement(206554..207048) Staphylococcus aureus subsp. aureus MRSA252 2860208 YP_039648.1 CDS SAR0183 NC_002952.2 207318 208088 R Similar to Bacillus stearothermophilus acetylglutamate kinase ArgB SW:ARGB_BACST (Q07905) (258 aa) fasta scores: E(): 1.8e-24, 35.294% id in 255 aa, and to Bacillus halodurans N-acetylglutamate 5-phosphotransferase ArgB TR:Q9K8V4 (EMBL:AP001517) (260 aa) fasta scores: E(): 3.7e-27, 36.328% id in 256 aa; amino acid kinase complement(207318..208088) Staphylococcus aureus subsp. aureus MRSA252 2860209 YP_039649.1 CDS argJ NC_002952.2 208104 209345 R bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase complement(208104..209345) Staphylococcus aureus subsp. aureus MRSA252 2859855 YP_039650.1 CDS argC NC_002952.2 209357 210391 R catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase complement(209357..210391) Staphylococcus aureus subsp. aureus MRSA252 2859852 YP_039651.1 CDS SAR0186 NC_002952.2 210427 211611 R Similar to the C-terminal region of Rattus norvegicus ornithine aminotransferase precursor protein Oat SW:OAT_RAT (P04182) (439 aa) fasta scores: E(): 1e-68, 46.770% id in 387 aa, and to Bacillus subtilis ornithine aminotransferase RocD SW:OAT_BACSU (P38021) (401 aa) fasta scores: E(): 4.6e-84, 51.151% id in 391 aa. Similar to SAR0919, 57.179% identity (57.179% ungapped) in 390 aa overlap; ornithine aminotransferase complement(210427..211611) Staphylococcus aureus subsp. aureus MRSA252 2860210 YP_039652.1 CDS SAR0187 NC_002952.2 211864 213219 R Similar to Lactobacillus delbrueckii branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_LACDL (P54104) (446 aa) fasta scores: E(): 1.5e-65, 46.347% id in 438 aa, and to Bacillus subtilis branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_BACSU (P94499) (440 aa) fasta scores: E(): 4.7e-62, 44.196% id in 448 aa; branched-chain amino acid transport system carrier protein complement(211864..213219) Staphylococcus aureus subsp. aureus MRSA252 2860211 YP_039653.1 CDS SAR0188 NC_002952.2 213486 214043 R Similar to Bacillus subtilis hypothetical protein YwoC TR:P94573 (EMBL:Z82987) (189 aa) fasta scores: E(): 1.5e-29, 48.649% id in 185 aa, and to Escherichia coli hypothetical protein YecD SW:YECD_ECOLI (P37347) (199 aa) fasta scores: E(): 1.5e-20, 40.541% id in 185 aa; isochorismatase complement(213486..214043) Staphylococcus aureus subsp. aureus MRSA252 2860212 YP_039654.1 CDS SAR0189 NC_002952.2 214110 215750 R Similar to Enterobacter cloacae indole-3-pyruvate decarboxylase IpdC SW:DCIP_ENTCL (P23234) (552 aa) fasta scores: E(): 1.6e-73, 39.060% id in 553 aa, and to Pseudomonas putida indolepyruvate decarboxylase IpdC TR:Q9FDC2 (EMBL:AF285632) (546 aa) fasta scores: E(): 2.6e-74, 39.241% id in 553 aa; thiamine pyrophosphate enzyme complement(214110..215750) Staphylococcus aureus subsp. aureus MRSA252 2860213 YP_039655.1 CDS glcA NC_002952.2 216022 218067 R Similar to Staphylococcus carnosus PTS system, glucose-specific IIABC component GlcA TR:Q57071 (EMBL:X93360) (675 aa) fasta scores: E(): 1.8e-187, 75.695% id in 683 aa, and to Bacillus halodurans PTS system, glucose-specific enzyme II, A component BH0844 TR:Q9KEK8 (EMBL:AP001510) (675 aa) fasta scores: E(): 1.8e-144, 59.647% id in 679 aa. Similar to SAR2618, 59.584% identity (61.692% ungapped) in 673 aa overlap; glucose-specific PTS transporter protein, IIABC component complement(216022..218067) Staphylococcus aureus subsp. aureus MRSA252 2859916 YP_039656.1 CDS SAR0191 NC_002952.2 218652 219707 D Similar to Lactococcus lactis hypothetical protein YleB TR:Q9CGG7 (EMBL:AE006345) (353 aa) fasta scores: E(): 1.3e-32, 33.239% id in 355 aa, and to Bacillus halodurans hypothetical protein BH3573 TR:Q9K701 (EMBL:AP001519) (351 aa) fasta scores: E(): 2.9e-27, 31.534% id in 352 aa; hypothetical protein 218652..219707 Staphylococcus aureus subsp. aureus MRSA252 2860214 YP_039657.1 CDS murQ NC_002952.2 219704 220603 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 219704..220603 Staphylococcus aureus subsp. aureus MRSA252 2860215 YP_039658.1 CDS SAR0193 NC_002952.2 220615 222069 D Similar to Salmonella typhimurium PTS system, sucrose-specific IIBC component ScrA SW:PTSB_SALTY (P08470) (456 aa) fasta scores: E(): 1e-28, 31.092% id in 476 aa, and to Lactococcus lactis sucrose-specific PTS system IIBC component YleD TR:Q9CGG5 (EMBL:AE006345) (454 aa) fasta scores: E(): 5.1e-88, 56.710% id in 462 aa; sucrose-specific PTS transporter protein 220615..222069 Staphylococcus aureus subsp. aureus MRSA252 2860216 YP_039659.1 CDS SAR0194 NC_002952.2 222069 222947 D Similar to Lactococcus lactis transcription regulator YleF TR:Q9CGG3 (EMBL:AE006345) (283 aa) fasta scores: E(): 1.5e-26, 32.971% id in 276 aa, and to Thermotoga maritima hypothetical protein RpiR family transcriptional regulator TM0326 SW:Y326_THEMA (Q9WYG1) (280 aa) fasta scores: E(): 2.8e-19, 29.720% id in 286 aa. Similar to SAR2399, 54.639% identity (54.828% ungapped) in 291 aa overlap; transcriptional regulator 222069..222947 Staphylococcus aureus subsp. aureus MRSA252 2860217 YP_039660.1 CDS SAR0195 NC_002952.2 223142 223423 R Poor database matches, similar to an internal region of Schizolachnus pineti ATP synthase A chain subunit 6 Atp6 TR:Q9B6H4 (EMBL:AJ298678) (217 aa) fasta scores: E(): 2.1, 30.208% id in 96 aa. Doubtful CDS; hypothetical protein complement(223142..223423) Staphylococcus aureus subsp. aureus MRSA252 2860218 YP_039661.1 CDS SAR0196 NC_002952.2 223636 226425 D Similar to Escherichia coli type I restriction enzyme EcoR124II R protein HsdR SW:T1R1_ECOLI (P10486) (1033 aa) fasta scores: E(): 3.2e-17, 35.119% id in 1008 aa, and to Helicobacter pylori type I restriction enzyme R protein HP0846 TR:O25517 (EMBL:AE000595) (866 aa) fasta scores: E(): 6.6e-77, 37.355% id in 862 aa; type I restriction enzyme 223636..226425 Staphylococcus aureus subsp. aureus MRSA252 2860219 YP_039662.1 CDS SAR0197 NC_002952.2 226625 227488 D Previously sequenced as Staphylococcus aureus hypothetical 33.2 kDa protein TR:Q9RL83 (EMBL:Y18638) (280 aa) fasta scores: E(): 3.8e-98, 96.774% id in 279 aa. Internal region of the CDS is similar internal region of bacteriophage P4 cII protein SW:RCII_BPP4 (P13059) (264 aa) fasta scores: E(): 0.00028, 26.222% id in 225 aa; hypothetical protein 226625..227488 Staphylococcus aureus subsp. aureus MRSA252 2860220 YP_039663.1 CDS SAR0198 NC_002952.2 227693 229285 R Similar to Rhizobium meliloti probable ABC transporter ATP-binding protein SMA1434 TR:AAK65441 (EMBL:AE007265) (550 aa) fasta scores: E(): 3.9e-76, 44.318% id in 528 aa, and to Rhizobium loti peptide ABC transporter ATP-binding protein MLL5490 TR:BAB51933 (EMBL:AP003006) (543 aa) fasta scores: E(): 6.8e-72, 43.289% id in 529 aa. Similar to SAR0951, 50.763% identity (50.763% ungapped) in 262 aa overlap; ABC transporter ATP-binding protein complement(227693..229285) Staphylococcus aureus subsp. aureus MRSA252 2860221 YP_039664.1 CDS SAR0199 NC_002952.2 229413 230720 D Possible alternative translational start sites. C-terminal region is similar to Bacillus subtilis dipeptide ABC transporter permease DppB SW:DPPB_BACSU (P26903) (308 aa) fasta scores: E(): 8.1e-31, 32.993% id in 294 aa, and Bacillus halodurans oligopeptide ABC transporter BH0029 TR:Q9KGM9 (EMBL:AP001507) (314 aa) fasta scores: E(): 1.4e-36, 39.799% id in 299 aa; ABC transporter permease 229413..230720 Staphylococcus aureus subsp. aureus MRSA252 2860222 YP_039665.1 CDS SAR0200 NC_002952.2 230726 231889 D C-terminal region is similar to Bacillus firmus dipeptide ABC transporter permease DppC SW:DPPC_BACFI (P94312) (304 aa) fasta scores: E(): 9.3e-41, 40.071% id in 282 aa, and Bacillus halodurans oligopeptide ABC transporter BH0030 TR:Q9KGM8 (EMBL:AP001507) (301 aa) fasta scores: E(): 1.1e-42, 41.971% id in 274 aa. Possible alternative translational start sites; ABC transporter permease 230726..231889 Staphylococcus aureus subsp. aureus MRSA252 2860223 YP_039666.1 CDS rlp NC_002952.2 231906 233681 D Previously sequenced as Staphylococcus aureus RGD-containing lipoprotein Rlp TR:Q9EY53 (EMBL:AY007316) (591 aa) fasta scores: E(): 2.8e-213, 99.831% id in 591 aa; RGD-containing lipoprotein 231906..233681 Staphylococcus aureus subsp. aureus MRSA252 2859274 YP_039667.1 CDS SAR0202 NC_002952.2 233719 235725 D Similar to Bacillus subtilis gamma-glutamyltranspeptidase precursor Ggt SW:GGT_BACSU (P54422) (587 aa) fasta scores: E(): 8.5e-75, 38.532% id in 545 aa, and to Escherichia coli gamma-glutamyltranspeptidase precursor Ggt SW:GGT_ECOLI (P18956) (580 aa) fasta scores: E(): 1.6e-57, 34.615% id in 546 aa. CDS is truncated at the N-terminus and extended at the C-terminus in comparison to the B. subtilis and E. coli proteins; gamma-glutamyltranspeptidase 233719..235725 Staphylococcus aureus subsp. aureus MRSA252 2860224 YP_039668.1 CDS acpD NC_002952.2 236262 236888 R FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase complement(236262..236888) Staphylococcus aureus subsp. aureus MRSA252 2860225 YP_039669.1 CDS SAR0204 NC_002952.2 237097 237675 D No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Staphylococcus aureus peptidoglycan hydrolase LytM TR:O33599 (EMBL:L77194) (322 aa) fasta scores: E(): 1.3e-17, 41.791% id in 134 aa, and to Staphylococcus simulans lysostaphin precursor Lss SW:LSTP_STASI (P10547) (493 aa) fasta scores: E(): 4e-17, 40.789% id in 152 aa; peptidase 237097..237675 Staphylococcus aureus subsp. aureus MRSA252 2860226 YP_039670.1 CDS SAR0205 NC_002952.2 238058 239155 D Similar to Thermococcus litoralis maltose transport protein MalK TR:Q9YGA6 (EMBL:AF121946) (372 aa) fasta scores: E(): 1.4e-60, 52.279% id in 373 aa, and to Bacillus subtilis probable multiple sugar-binding transport ATP-binding protein MsmX SW:MSMX_BACSU (P94360) (365 aa) fasta scores: E(): 1.8e-82, 65.479% id in 365 aa; ABC transporter ATP-binding protein 238058..239155 Staphylococcus aureus subsp. aureus MRSA252 2860227 YP_039671.1 CDS SAR0206 NC_002952.2 239168 240439 D Similar to Streptococcus pneumoniae maltose/maltodextrin-binding protein precursor MalX SW:MALX_STRPN (P29850) (423 aa) fasta scores: E(): 1.8e-28, 29.535% id in 430 aa, and to Bacillus halodurans maltose/maltodextrin-binding protein BH2926 TR:Q9K8S7 (EMBL:AP001517) (429 aa) fasta scores: E(): 4e-61, 40.610% id in 426 aa; extracellular sugar-binding lipoprotein 239168..240439 Staphylococcus aureus subsp. aureus MRSA252 2860228 YP_039672.1 CDS SAR0207 NC_002952.2 240442 241710 D Similar to Streptococcus pneumoniae maltodextrin ABC transporter permease MalC SW:MALC_STRPN (Q04698) (430 aa) fasta scores: E(): 3.1e-69, 44.860% id in 428 aa, and to Bacillus halodurans maltose/maltodextrin ABC transporter permease BH2925 TR:Q9K8S8 (EMBL:AP001517) (430 aa) fasta scores: E(): 2.4e-113, 66.986% id in 418 aa; sugar ABC transporter permease 240442..241710 Staphylococcus aureus subsp. aureus MRSA252 2860229 YP_039673.1 CDS SAR0208 NC_002952.2 241712 242551 D Similar to Streptococcus pneumoniae maltodextrin ABC transporter permease MalD SW:MALD_STRPN (Q04699) (277 aa) fasta scores: E(): 1.9e-37, 44.569% id in 267 aa, and to Bacillus halodurans maltose/maltodextrin ABC transporter permease BH2924 TR:Q9K8S9 (EMBL:AP001517) (280 aa) fasta scores: E(): 3.6e-76, 72.857% id in 280 aa; sugar ABC transporter permease 241712..242551 Staphylococcus aureus subsp. aureus MRSA252 2860230 YP_039674.1 CDS SAR0209 NC_002952.2 242725 243804 D Similar to an internal region of Zymomonas mobilis glucose--fructose oxidoreductase Gfo SW:GFO_ZYMMO (Q07982) (439 aa) fasta scores: E(): 5.2e-17, 28.652% id in 356 aa. Full CDS is similar to Listeria monocytogenes NADH-dependent dehydrogenase homologue LapC TR:O52495 (EMBL:AF039207) (358 aa) fasta scores: E(): 7.8e-100, 67.507% id in 357 aa; oxidoreductase 242725..243804 Staphylococcus aureus subsp. aureus MRSA252 2860231 YP_039675.1 CDS SAR0210 NC_002952.2 243829 244869 D Similar to Bacillus halodurans hypothetical protein BH2165 TR:Q9KAX1 (EMBL:AP001514) (348 aa) fasta scores: E(): 2.1e-51, 41.040% id in 346 aa, and to Listeria monocytogenes NADH-dependent dehydrogenase homologue LapC TR:O52495 (EMBL:AF039207) (358 aa) fasta scores: E(): 1.2e-38, 38.873% id in 355 aa; oxidoreductase 243829..244869 Staphylococcus aureus subsp. aureus MRSA252 2860232 YP_039676.1 CDS SAR0211 NC_002952.2 244924 245892 D Similar to Bacillus halodurans hypothetical protein BH1249 TR:Q9KDG4 (EMBL:AP001511) (322 aa) fasta scores: E(): 1.2e-81, 58.385% id in 322 aa, and to Bacillus subtilis hypothetical protein YfiH SW:YFIH_BACSU (P54724) (313 aa) fasta scores: E(): 1.7e-36, 39.130% id in 299 aa; hypothetical protein 244924..245892 Staphylococcus aureus subsp. aureus MRSA252 2860233 YP_039677.1 CDS SAR0212 NC_002952.2 246251 246745 R Similar to Pasteurella multocida hypothetical protein PM0984 TR:Q9CM58 (EMBL:AE006137) (172 aa) fasta scores: E(): 2.3e-24, 51.515% id in 165 aa, and to Haemophilus influenzae hypothetical protein HI0318 SW:Y318_HAEIN (P43984) (172 aa) fasta scores: E(): 4.1e-24, 52.381% id in 168 aa; hypothetical protein complement(246251..246745) Staphylococcus aureus subsp. aureus MRSA252 2860234 YP_039678.1 CDS uhpT NC_002952.2 246978 248357 D cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 246978..248357 Staphylococcus aureus subsp. aureus MRSA252 2860412 YP_039679.1 CDS SAR0214 NC_002952.2 248716 249474 R Probable two-component regulatory system family, response regulator protein. Similar to Streptococcus pyogenes two-component response regulator SPY1062 TR:Q99ZU9 (EMBL:AE006550) (262 aa) fasta scores: E(): 1.2e-21, 34.568% id in 243 aa, and to Bacillus halodurans two-component response regulator BH3679 TR:Q9K6P9 (EMBL:AP001519) (257 aa) fasta scores: E(): 3.6e-13, 28.346% id in 254 aa; response regulator complement(248716..249474) Staphylococcus aureus subsp. aureus MRSA252 2860235 YP_039680.1 CDS SAR0215 NC_002952.2 249467 251023 R Probable two-component regulatory system family, sensor kinase. No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Streptococcus pyogenes two-component sensor histidine kinase SPY1061 TR:Q99ZV0 (EMBL:AE006550) (549 aa) fasta scores: E(): 2.2e-15, 25.978% id in 358 aa, and Bacillus halodurans two-component sensor histidine kinase BH3678 TR:Q9K6Q0 (EMBL:AP001519) (605 aa) fasta scores: E(): 4.2e-13, 25.915% id in 328 aa; sensor kinase complement(249467..251023) Staphylococcus aureus subsp. aureus MRSA252 2860539 YP_039681.1 CDS SAR0216 NC_002952.2 251020 251988 R Similar to Treponema hyodysenteriae periplasmic-iron-binding protein BitA TR:Q9Z4R9 (EMBL:U75349) (336 aa) fasta scores: E(): 7.2e-24, 29.897% id in 291 aa, and to Streptococcus pyogenes periplasmic-iron-binding protein SPY1063 TR:Q99ZU8 (EMBL:AE006550) (323 aa) fasta scores: E(): 1.2e-20, 26.885% id in 305 aa; lipoprotein complement(251020..251988) Staphylococcus aureus subsp. aureus MRSA252 2860540 YP_039682.1 CDS SAR0217 NC_002952.2 252576 254825 D Similar to Escherichia coli formate acetyltransferase 1 PflB SW:PFLB_ECOLI (P09373) (759 aa) fasta scores: E(): 1.4e-204, 66.227% id in 758 aa, and to Clostridium pasteurianum formate acetyltransferase Pfl SW:PFL_CLOPA (Q46266) (740 aa) fasta scores: E(): 3.5e-196, 65.041% id in 738 aa; formate acetyltransferase 252576..254825 Staphylococcus aureus subsp. aureus MRSA252 2860035 YP_039683.1 CDS SAR0218 NC_002952.2 254848 255603 D Similar to Streptococcus mutans pyruvate formate-lyase activating enzyme Act SW:PFLA_STRMU (O68575) (263 aa) fasta scores: E(): 5.3e-45, 50.000% id in 240 aa, and to Listeria monocytogenes pyruvate-formate lyase activating enzyme PflC TR:Q9X767 (EMBL:AJ009627) (248 aa) fasta scores: E(): 6.9e-51, 53.814% id in 236 aa; pyruvate formate-lyase activating enzyme 254848..255603 Staphylococcus aureus subsp. aureus MRSA252 2860627 YP_039684.1 CDS SAR0219 NC_002952.2 255707 255874 D hypothetical protein 255707..255874 Staphylococcus aureus subsp. aureus MRSA252 2860628 YP_039685.1 CDS SAR0220 NC_002952.2 255925 257688 D Similar to Streptococcus pyogenes glycerophosphodiester phosphodiesterase SPY0839 TR:Q9A0C2 (EMBL:AE006534) (577 aa) fasta scores: E(): 1.2e-39, 35.233% id in 579 aa, and to Lactococcus lactis hypothetical protein YuhH TR:Q9CE50 (EMBL:AE006429) (617 aa) fasta scores: E(): 5.4e-37, 27.005% id in 611 aa; hypothetical protein 255925..257688 Staphylococcus aureus subsp. aureus MRSA252 2860629 YP_039686.1 CDS SAR0221 NC_002952.2 257852 258196 R hypothetical protein complement(257852..258196) Staphylococcus aureus subsp. aureus MRSA252 2860630 YP_039687.1 CDS SAR0222 NC_002952.2 258386 260215 D Similar to Staphylococcus aureus staphylocoagulase precursor SW:STC1_STAAU (P07767) (658 aa) fasta scores: E(): 2.3e-144, 73.520% id in 608 aa, and to Staphylococcus aureus staphylocoagulase precursor SW:STC2_STAAU (P17855) (715 aa) fasta scores: E(): 2.3e-141, 72.250% id in 609 aa. Contains a C-terminal imperfect repeat (ARPTQNKPSETNAYNVTTHANGQVSYG x4). CDS contains less amino acid residues at the C-terminus in comparison to other orthologues; staphylocoagulase precursor 258386..260215 Staphylococcus aureus subsp. aureus MRSA252 2860631 YP_039688.1 CDS fadA NC_002952.2 260802 261986 R Similar to Brassica napus glyoxysomal beta-ketoacyl-thiolase TR:Q43742 (EMBL:X93015) (462 aa) fasta scores: E(): 2.8e-56, 46.173% id in 392 aa. Previously sequenced as Staphylococcus aureus 3-ketoacyl-CoA transferase FadA TR:AAK51158 (EMBL:AY033081) (397 aa) fasta scores: E(): 4.6e-142, 99.239% id in 394 aa; thiolase complement(260802..261986) Staphylococcus aureus subsp. aureus MRSA252 2859623 YP_039689.1 CDS fadB NC_002952.2 262016 264277 R N-terminal region is similar to Mus musculus short chain 3-hydroxyacyl-CoA dehydrogenase precursor HadH SW:HCDH_MOUSE (Q61425) (314 aa) fasta scores: E(): 3e-21, 33.333% id in 294 aa. Previously sequenced as Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase FadB TR:AAK51157 (EMBL:AY033081) (753 aa) fasta scores: E(): 0, 98.672% id in 753 aa; fatty oxidation complex protein complement(262016..264277) Staphylococcus aureus subsp. aureus MRSA252 2859624 YP_039690.1 CDS fadD NC_002952.2 264464 265675 R Similar to Mus musculus mitochondrial glutaryl-CoA dehydrogenase GcdH SW:GCDH_MOUSE (Q60759) (438 aa) fasta scores: E(): 1e-29, 32.659% id in 346 aa. Previously sequenced as Staphylococcus aureus acyl-CoA dehydrogenase FadD TR:AAK51156 (EMBL:AY033081) (418 aa) fasta scores: E(): 1e-154, 100.000% id in 403 aa; acyl-CoA dehydrogenase complement(264464..265675) Staphylococcus aureus subsp. aureus MRSA252 2859625 YP_039691.1 CDS fadE NC_002952.2 265787 267292 R Similar to Rhizobium leguminosarum malonyl CoA synthetase MatB TR:Q9ZIP5 (EMBL:AF117694) (504 aa) fasta scores: E(): 3.1e-38, 27.866% id in 506 aa. Previously sequenced as Staphylococcus aureus acyl-CoA synthetase FadE TR:AAK51155 (EMBL:AY033081) (501 aa) fasta scores: E(): 8.5e-198, 99.401% id in 501 aa; acyl-CoA synthetase complement(265787..267292) Staphylococcus aureus subsp. aureus MRSA252 2859626 YP_039692.1 CDS fadX NC_002952.2 267318 268880 R Weakly similar to Homo sapiens mitochondrial succinyl-CoA:3-ketoacid-coenzyme A transferase SCOT SW:SCOT_HUMAN (P55809) (520 aa) fasta scores: E(): 2e-05, 21.681% id in 452 aa. Previously sequenced as Staphylococcus aureus acetyl-CoA/acetoacetyl-CoA transferase FadX TR:AAK51154 (EMBL:AY033081) (525 aa) fasta scores: E(): 2.2e-208, 98.654% id in 520 aa; acetyl-CoA transferase complement(267318..268880) Staphylococcus aureus subsp. aureus MRSA252 2860658 YP_039693.1 CDS SAR0228 NC_002952.2 269254 269925 D Similar to Synechocystis sp hypothetical protein SLR0541 TR:Q55488 (EMBL:D64006) (236 aa) fasta scores: E(): 6.7e-21, 34.615% id in 208 aa, and to Pseudomonas aeruginosa probable glutamine amidotransferase PA0531 TR:Q9I605 (EMBL:AE004489) (238 aa) fasta scores: E(): 1.7e-20, 33.476% id in 233 aa; glutamine amidotransferase 269254..269925 Staphylococcus aureus subsp. aureus MRSA252 2860632 YP_039694.1 CDS SAR0229 NC_002952.2 270148 271290 D No significant database matches to the full length CDS. C-terminal region is similar to similar to Pyrococcus abyssi hypothetical protein PAB0037 TR:Q9V2K2 (EMBL:AJ248283) (249 aa) fasta scores: E(): 5.7e-07, 28.384% id in 229 aa, and to Streptococcus pyogenes hypothetical protein SPY1366 TR:Q99Z72 (EMBL:AE006574) (269 aa) fasta scores: E(): 0.0023, 23.675% id in 283 aa. Possible alternative translational start sites; hypothetical protein 270148..271290 Staphylococcus aureus subsp. aureus MRSA252 2860633 YP_039695.1 CDS SAR0230 NC_002952.2 271601 273076 R Similar to Bacillus halodurans nickel ABC transporter BH1796 TR:Q9KBX8 (EMBL:AP001513) (528 aa) fasta scores: E(): 4.7e-23, 31.653% id in 496 aa, and to Agrobacterium radiobacter agropinic acid permease AgaA TR:O50260 (EMBL:AF242881) (509 aa) fasta scores: E(): 5.6e-16, 26.261% id in 476 aa; extracellular solute-binding lipoprotein complement(271601..273076) Staphylococcus aureus subsp. aureus MRSA252 2860634 YP_039696.1 CDS SAR0231 NC_002952.2 273274 273630 R Similar to Streptomyces coelicolor hypothetical protein SC2H2.18 TR:Q9F3D7 (EMBL:AL450289) (119 aa) fasta scores: E(): 1.5e-16, 42.857% id in 119 aa, and to Rhizobium loti hypothetical protein MLL7394 TR:BAB53507 (EMBL:AP003011) (120 aa) fasta scores: E(): 1.5e-16, 48.305% id in 118 aa; hypothetical protein complement(273274..273630) Staphylococcus aureus subsp. aureus MRSA252 2860635 YP_039697.1 CDS SAR0232 NC_002952.2 273787 273960 R hypothetical protein complement(273787..273960) Staphylococcus aureus subsp. aureus MRSA252 2860636 YP_039698.1 CDS SAR0233 NC_002952.2 273985 275130 R Similar to Bacillus subtilis flavohemoprotein Hmp SW:HMPA_BACSU (P49852) (399 aa) fasta scores: E(): 7.5e-41, 38.653% id in 401 aa, and to Vibrio parahaemolyticus flavohemoprotein Hmp SW:HMPA_VIBPA (P40609) (394 aa) fasta scores: E(): 2.3e-35, 34.596% id in 396 aa; flavohemoprotein complement(273985..275130) Staphylococcus aureus subsp. aureus MRSA252 2860637 YP_039699.1 CDS ldh1 NC_002952.2 275703 276656 D Similar to Bacillus subtilis L-lactate dehydrogenase Ldh SW:LDH_BACSU (P13714) (320 aa) fasta scores: E(): 1.5e-73, 64.630% id in 311 aa, and to Bacillus stearothermophilus L-lactate dehydrogenase Ldh TR:Q9S0N0 (EMBL:AB033627) (317 aa) fasta scores: E(): 1.4e-77, 67.101% id in 307 aa. Similar to SAR2680, 59.223% identity (59.609% ungapped) in 309 aa overlap; L-lactate dehydrogenase 275703..276656 Staphylococcus aureus subsp. aureus MRSA252 2859695 YP_039700.1 CDS SAR0235 NC_002952.2 276977 278506 R Similar to the N-terminal region of Bacillus subtilis PTS system, glucose-specific IIABC component PtsG SW:PTGA_BACSU (P20166) (699 aa) fasta scores: E(): 6.6e-88, 47.500% id in 520 aa. Full length CDS is similar to Borrelia burgdorferi PTS system, glucose-specific IIBC component BB0645 TR:O51590 (EMBL:AE001166) (514 aa) fasta scores: E(): 6.5e-124, 61.961% id in 510 aa; PTS transport system, IIBC component complement(276977..278506) Staphylococcus aureus subsp. aureus MRSA252 2860638 YP_039701.1 CDS SAR0236 NC_002952.2 278870 279805 D Similar to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SW:IUNH_CRIFA (Q27546) (314 aa) fasta scores: E(): 4.5e-38, 37.954% id in 303 aa, and to Escherichia coli hypothetical protein YbeK SW:YBEK_ECOLI (P41409) (311 aa) fasta scores: E(): 1.7e-45, 45.367% id in 313 aa; inosine-uridine preferring nucleoside hydrolase 278870..279805 Staphylococcus aureus subsp. aureus MRSA252 2860639 YP_039702.1 CDS SAR0237 NC_002952.2 279841 279987 D hypothetical protein 279841..279987 Staphylococcus aureus subsp. aureus MRSA252 2860640 YP_039703.1 CDS SAR0240 NC_002952.2 282224 282691 D Similar to Escherichia coli PTS system, galactitol-specific IIA component GatA SW:PTKA_ECOLI (P37187) (150 aa) fasta scores: E(): 3.9e-05, 28.986% id in 138 aa, and to Bacillus halodurans phosphotransferase system FruA TR:Q9Z9U3 (EMBL:AB011837) (160 aa) fasta scores: E(): 1.9e-17, 43.421% id in 152 aa; PTS transport system, IIA component 282224..282691 Staphylococcus aureus subsp. aureus MRSA252 2860642 YP_039704.1 CDS SAR0241 NC_002952.2 282714 282992 D Similar to Escherichia coli PTS system, galactitol-specific IIB component GatB SW:PTKB_ECOLI (P37188) (94 aa) fasta scores: E(): 3.7e-09, 37.363% id in 91 aa, and to Bacillus halodurans PTS system, galactitol-specific enzyme IIB component GatB TR:Q9KGB5 (EMBL:AP001507) (94 aa) fasta scores: E(): 1.5e-24, 81.319% id in 91 aa; PTS transport system, IIB component 282714..282992 Staphylococcus aureus subsp. aureus MRSA252 2860643 YP_039705.1 CDS SAR0242 NC_002952.2 283219 284478 D Similar to Escherichia coli PTS system, galactitol-specific IIC component GatC SW:PTKC_ECOLI (P37189) (451 aa) fasta scores: E(): 5.1e-68, 44.337% id in 415 aa, and to Bacillus halodurans PTS system galactitol-specific enzyme IIC component GatC TR:Q9Z9U2 (EMBL:AB011837) (419 aa) fasta scores: E(): 4.6e-121, 78.043% id in 419 aa; PTS transport system, IIC component 283219..284478 Staphylococcus aureus subsp. aureus MRSA252 2860644 YP_039706.1 CDS SAR0243 NC_002952.2 284496 285551 D Similar to Bacillus subtilis sorbitol dehydrogenase GutB SW:DHSO_BACSU (Q06004) (352 aa) fasta scores: E(): 2.9e-30, 35.077% id in 325 aa, and to Bacillus halodurans sorbitol dehydrogenase GutB SW:DHSO_BACHD (Q9Z9U1) (343 aa) fasta scores: E(): 1.6e-83, 62.974% id in 343 aa; zinc-binding dehydrogenase 284496..285551 Staphylococcus aureus subsp. aureus MRSA252 2860645 YP_039707.1 CDS SAR0244 NC_002952.2 285553 285699 D Poor database matches. Similar to the C-terminal region of Bacillus halodurans hypothetical protein TR:Q9Z9U0 (EMBL:AB011837) (100 aa) fasta scores: E(): 5e-05, 47.727% id in 44 aa; hypothetical protein 285553..285699 Staphylococcus aureus subsp. aureus MRSA252 2860646 YP_039708.1 CDS SAR0245 NC_002952.2 285723 286766 D Similar to Escherichia coli galactitol-1-phosphate 5-dehydrogenase GatD SW:GATD_ECOLI (P37190) (346 aa) fasta scores: E(): 3.7e-37, 36.452% id in 310 aa, and to Bacillus halodurans sorbitol dehydrogenase GutB TR:Q9KGB7 (EMBL:AP001507) (354 aa) fasta scores: E(): 4.1e-78, 56.936% id in 346 aa; zinc-binding dehydrogenase 285723..286766 Staphylococcus aureus subsp. aureus MRSA252 2860647 YP_039709.1 CDS ispD NC_002952.2 287294 288010 D 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 287294..288010 Staphylococcus aureus subsp. aureus MRSA252 2860648 YP_039710.1 CDS SAR0247 NC_002952.2 288003 289028 D Similar to Escherichia coli L-idonate 5-dehydrogenase IdnD SW:IDND_ECOLI (P39346) (343 aa) fasta scores: E(): 4.8e-05, 25.000% id in 308 aa, and to Thermoplasma volcanium alcohol dehydrogenase TVG0995648 TR:BAB60114 (EMBL:AP000994) (335 aa) fasta scores: E(): 1.2e-07, 25.581% id in 344 aa. Similar to SAR0253, 80.645% identity (80.645% ungapped) in 341 aa overlap; zinc-binding dehydrogenase 288003..289028 Staphylococcus aureus subsp. aureus MRSA252 2860649 YP_039711.1 CDS SAR0248 NC_002952.2 289050 290744 D No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Staphylococcus epidermidis CDP-glycerol:poly(glycerolphosphate) glycerophosphotransferase TagF TR:Q9RPD1 (EMBL:AF162863) (721 aa) fasta scores: E(): 1.2e-21, 26.873% id in 387 aa, and Haemophilus influenzae hypothetical protein TR:Q48156 (EMBL:Z37516) (789 aa) fasta scores: E(): 2e-33, 30.900% id in 411 aa. Similar to SAR0254, 79.211% identity (79.211% ungapped) in 558 aa overlap; hypothetical protein 289050..290744 Staphylococcus aureus subsp. aureus MRSA252 2860650 YP_039712.1 CDS SAR0249 NC_002952.2 291010 291171 R No significant database matches. Doubtful CDS; hypothetical protein complement(291010..291171) Staphylococcus aureus subsp. aureus MRSA252 2860651 YP_039713.1 CDS SAR0250 NC_002952.2 291336 291461 D No significant database matches. Doubtful CDS; hypothetical protein 291336..291461 Staphylococcus aureus subsp. aureus MRSA252 2860652 YP_039714.1 CDS SAR0251 NC_002952.2 291714 292883 D Similar to the C-terminal regions of Bacillus subtilis teichoic acid biosynthesis protein F TagF SW:TAGF_BACSU (P13485) (746 aa) fasta scores: E(): 5.6e-77, 48.139% id in 403 aa, and to Staphylococcus epidermidis CDP-glycerol:poly(glycerolphosphate) glycerophosphotransferase TagF TR:Q9RPD1 (EMBL:AF162863) (721 aa) fasta scores: E(): 7e-72, 46.650% id in 403 aa; teichoic acid biosynthesis protein 291714..292883 Staphylococcus aureus subsp. aureus MRSA252 2860653 YP_039715.1 CDS ispD NC_002952.2 293159 293875 D 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 293159..293875 Staphylococcus aureus subsp. aureus MRSA252 2860654 YP_039716.1 CDS SAR0253 NC_002952.2 293868 294893 D Similar to Escherichia coli L-idonate 5-dehydrogenase IdnD SW:IDND_ECOLI (P39346) (343 aa) fasta scores: E(): 6.7e-06, 23.006% id in 326 aa, and to Candida sp HA167 xylitol dehydrogenase Xdh TR:O74230 (EMBL:AF072541) (353 aa) fasta scores: E(): 5.1e-06, 24.425% id in 348 aa. Similar to SAR0247, 80.645% identity (80.645% ungapped) in 341 aa overlap; zinc-binding dehydrogenase 293868..294893 Staphylococcus aureus subsp. aureus MRSA252 2860655 YP_039717.1 CDS SAR0254 NC_002952.2 294915 296603 D C-terminus is similar to Staphylococcus epidermidis epidermidis CDP-glycerol:poly(glycerolphosphate) glycerophosphotransferase TagF TR:Q9RPD1 (EMBL:AF162863) (721 aa) fasta scores: E(): 6.3e-19, 24.067% id in 536 aa. Full length CDS is similar to Haemophilus influenzae hypothetical protein TR:Q48156 (EMBL:Z37516) (789 aa) fasta scores: E(): 2.7e-32, 27.563% id in 595 aa. Similar to SAR0248, 79.211% identity (79.211% ungapped) in 558 aa overlap; hypothetical protein 294915..296603 Staphylococcus aureus subsp. aureus MRSA252 2860995 YP_039718.1 CDS SAR0255 NC_002952.2 296636 298360 D No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Streptococcus thermophilus exopolysaccharide biosynthesis protein EpsI TR:Q56046 (EMBL:U40830) (324 aa) fasta scores: E(): 1e-11, 31.522% id in 276 aa, and Lactobacillus delbrueckii glycosyltransferase EpsJ TR:Q9F0B8 (EMBL:AF267127) (327 aa) fasta scores: E(): 6.7e-13, 29.851% id in 268 aa; glycosyl transferase family protein 296636..298360 Staphylococcus aureus subsp. aureus MRSA252 2861468 YP_039719.1 CDS scdA NC_002952.2 298500 299174 D involved in peptidoglycan cross-linking; cell wall biosynthesis protein ScdA 298500..299174 Staphylococcus aureus subsp. aureus MRSA252 2859125 YP_039720.1 CDS lytS NC_002952.2 299425 301179 D Two-component regulatory system family, sensor kinase. Previously sequenced as Staphylococcus aureus autolysin sensor kinase LytS TR:Q53705 (EMBL:L42945) (584 aa) fasta scores: E(): 3.6e-213, 98.288% id in 584 aa. Similar to Bacillus subtilis autolysin sensor kinase lytS TR:P94513 (EMBL:Z75208) (593 aa) fasta scores: E(): 1.7e-102, 46.918% id in 584 aa; autolysin sensor kinase 299425..301179 Staphylococcus aureus subsp. aureus MRSA252 2859063 YP_039721.1 CDS lytR NC_002952.2 301182 301922 D Two-component regulatory system family, response regulator protein. Previously sequenced as Staphylococcus aureus autolysin response regulator LytR TR:P96456 (EMBL:L42945) (246 aa) fasta scores: E(): 9.6e-90, 98.780% id in 246 aa. Similar to Bacillus subtilis autolysin response regulator LytT TR:P94514 (EMBL:Z75208) (241 aa) fasta scores: E(): 4.4e-34, 40.664% id in 241 aa; two-component response regulator 301182..301922 Staphylococcus aureus subsp. aureus MRSA252 2859818 YP_039722.1 CDS lrgA NC_002952.2 302035 302478 D negatively regulates murein hydrolase activity; murein hydrolase regulator LrgA 302035..302478 Staphylococcus aureus subsp. aureus MRSA252 2859808 YP_039723.1 CDS lrgB NC_002952.2 302471 303172 D in conjunction with LrgA this protein inhibits the expression or activity of extracellular murein hydrolases; antiholin-like protein LrgB 302471..303172 Staphylococcus aureus subsp. aureus MRSA252 2859809 YP_039724.1 CDS SAR0261 NC_002952.2 303513 305804 D C-terminal region is similar to Pseudomonas aeruginosa nitric-oxide reductase subunit B NorB SW:NORB_PSEAE (Q59647) (466 aa) fasta scores: E(): 6e-24, 29.400% id in 483 aa. Full length CDS is similar to Alcaligenes eutrophus nitric oxide reductase TR:O30368 (EMBL:AF002217) (762 aa) fasta scores: E(): 1e-96, 35.894% id in 755 aa.; nitric oxide reductase 303513..305804 Staphylococcus aureus subsp. aureus MRSA252 2860271 YP_039725.1 CDS SAR0262 NC_002952.2 306030 306734 R Similar to Escherichia coli fatty acyl responsive regulator FarR SW:FARR_ECOLI (P13669) (240 aa) fasta scores: E(): 5.7e-11, 25.424% id in 236 aa, and to Bacillus subtilis hypothetical protein YydK TR:Q45591 (EMBL:D78193) (238 aa) fasta scores: E(): 7.3e-32, 40.870% id in 230 aa; GntR family transcriptional regulator complement(306030..306734) Staphylococcus aureus subsp. aureus MRSA252 2860272 YP_039726.1 CDS SAR0263 NC_002952.2 306881 307672 D Poor database matches to the full length CDS. Similar to the C-terminal regions of Staphylococcus carnosus PTS system, glucose-specific IIABC component GlcA TR:Q57071 (EMBL:X93360) (675 aa) fasta scores: E(): 1.1e-21, 33.065% id in 248 aa, and to Bacillus subtilis PTS system IIABC component YbfS SW:YBFS_BACSU (P39816) (631 aa) fasta scores: E(): 6.3e-18, 31.276% id in 243 aa; PTS transporter 306881..307672 Staphylococcus aureus subsp. aureus MRSA252 2860273 YP_039727.1 CDS bglA NC_002952.2 307688 309124 D Similar to Bacillus subtilis 6-phospho-beta-glucosidase BglA SW:BGLA_BACSU (P42973) (479 aa) fasta scores: E(): 1.3e-145, 70.146% id in 479 aa, and to Escherichia coli 6-phospho-beta-glucosidase BglA SW:BGLA_ECOLI (Q46829) (479 aa) fasta scores: E(): 1.6e-122, 60.714% id in 476 aa; 6-phospho-beta-glucosidase 307688..309124 Staphylococcus aureus subsp. aureus MRSA252 2858969 YP_039728.1 CDS SAR0265 NC_002952.2 309619 310380 R Similar to Haemophilus influenzae hypothetical protein HI0095 SW:Y095_HAEIN (Q57060) (251 aa) fasta scores: E(): 6e-57, 58.333% id in 252 aa, and to Pasteurella multocida hypothetical protein PM1158 TR:Q9CLQ7 (EMBL:AE006156) (251 aa) fasta scores: E(): 4.3e-55, 57.540% id in 252 aa; hypothetical protein complement(309619..310380) Staphylococcus aureus subsp. aureus MRSA252 2860274 YP_039729.1 CDS SAR0266 NC_002952.2 310631 311545 R Similar to Escherichia coli ribokinase RbsK SW:RBSK_ECOLI (P05054) (309 aa) fasta scores: E(): 9.4e-39, 40.604% id in 298 aa, and to Lactobacillus bavaricus ribokinase RbsK rbsK TR:Q9X4M5 (EMBL:AF115391) (302 aa) fasta scores: E(): 2.7e-56, 54.181% id in 299 aa; ribokinase complement(310631..311545) Staphylococcus aureus subsp. aureus MRSA252 2860275 YP_039730.1 CDS SAR0267 NC_002952.2 311573 311977 R cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase complement(311573..311977) Staphylococcus aureus subsp. aureus MRSA252 2860276 YP_039731.1 CDS SAR0268 NC_002952.2 311992 312873 R Similar to Staphylococcus xylosus glucose uptake protein GlcU TR:O07881 (EMBL:Y14043) (288 aa) fasta scores: E(): 1.6e-26, 34.256% id in 289 aa, and to Lactobacillus bavaricus ribose transporter RbsU TR:Q9X4M3 (EMBL:AF115391) (294 aa) fasta scores: E(): 2.6e-60, 55.442% id in 294 aa; sugar transport protein complement(311992..312873) Staphylococcus aureus subsp. aureus MRSA252 2860277 YP_039732.1 CDS SAR0269 NC_002952.2 313105 314103 R Similar to Escherichia coli ribose operon repressor RbsR SW:RBSR_ECOLI (P25551) (329 aa) fasta scores: E(): 8.6e-27, 29.697% id in 330 aa, and to Lactobacillus bavaricus rbs operon repressor RbsR TR:Q9X4M6 (EMBL:AF115391) (335 aa) fasta scores: E(): 2.3e-39, 39.228% id in 311 aa; LacI family regulatory protein complement(313105..314103) Staphylococcus aureus subsp. aureus MRSA252 2860278 YP_039733.1 CDS SAR0269a NC_002952.2 314320 314433 D No significant database matches. Doubtful CDS; hypothetical protein 314320..314433 Staphylococcus aureus subsp. aureus MRSA252 2860279 YP_039734.1 CDS SAR0270 NC_002952.2 314483 314875 D hypothetical protein 314483..314875 Staphylococcus aureus subsp. aureus MRSA252 2860280 YP_039735.1 CDS SAR0271 NC_002952.2 315004 316380 R Similar to Streptomyces lavendulae mitomycin export system protein Mct TR:Q9WVV3 (EMBL:AF127374) (484 aa) fasta scores: E(): 6e-22, 25.114% id in 438 aa, and to Pseudomonas aeruginosa probable MFS transporter PA2055 TR:Q9I260 (EMBL:AE004632) (471 aa) fasta scores: E(): 3.4e-24, 28.019% id in 414 aa; transport protein complement(315004..316380) Staphylococcus aureus subsp. aureus MRSA252 2860281 YP_039736.1 CDS SAR0272 NC_002952.2 316614 317606 D Similar to Bacillus sphaericus penicillin acylase SW:PAC_BACSH (P12256) (338 aa) fasta scores: E(): 8.1e-35, 29.483% id in 329 aa, and to Bacillus subtilis hypothetical protein YxeI SW:YXEI_BACSU (P54948) (328 aa) fasta scores: E(): 1.6e-35, 32.622% id in 328 aa; choloylglycine hydrolase 316614..317606 Staphylococcus aureus subsp. aureus MRSA252 2860282 YP_039737.1 CDS lytM NC_002952.2 317932 318882 D Previously sequenced as Staphylococcus aureus peptidoglycan hydrolase LytM TR:O33599 (EMBL:L77194) (322 aa) fasta scores: E(): 3.4e-113, 98.418% id in 316 aa. C-terminus is similar to an internal region of Staphylococcus staphylolyticus lysostaphin precursor Lss SW:LSTP_STAST (P10548) (480 aa) fasta scores: E(): 4.8e-19, 48.905% id in 137 aa; peptidoglycan hydrolase 317932..318882 Staphylococcus aureus subsp. aureus MRSA252 2859816 YP_039738.1 CDS SAR0274 NC_002952.2 318934 319593 R Similar to the N-terminal regions of Streptococcus pyogenes ABC transporter SPY0744 TR:Q9A0K0 (EMBL:AE006526) (307 aa) fasta scores: E(): 4.9e-17, 38.278% id in 209 aa, and Bacillus halodurans hypothetical protein YfiL TR:Q9RC44 (EMBL:AB024563) (310 aa) fasta scores: E(): 1.7e-16, 36.408% id in 206 aa; ABC transporter ATP-binding protein complement(318934..319593) Staphylococcus aureus subsp. aureus MRSA252 2860283 YP_039739.1 CDS SAR0275 NC_002952.2 319607 320527 R Poor database matches. Similar to N-terminal regions of Streptococcus pyogenes ABC transporter SPY0746 TR:Q9A0J8 (EMBL:AE006526) (372 aa) fasta scores: E(): 0.0045, 24.542% id in 273 aa, and Pyrococcus horikoshii hypothetical protein PH1531 TR:O59200 (EMBL:AP000006) (420 aa) fasta scores: E(): 0.058, 21.683% id in 309 aa; hypothetical protein complement(319607..320527) Staphylococcus aureus subsp. aureus MRSA252 2860284 YP_039740.1 CDS SAR0276 NC_002952.2 320524 321690 R Poor database matches. C-terminus is similar to internal regions of Borrelia burgdorferi conserved hypothetical integral membrane protein BB0584 TR:O51531 (EMBL:AE001160) (448 aa) fasta scores: E(): 0.48, 17.695% id in 243 aa, and to Buchnera aphidicola (subsp. Acyrthosiphon pisum) hypothetical transport protein BU466 SW:Y466_BUCAI (P57538) (390 aa) fasta scores: E(): 0.57, 22.778% id in 180 aa; hypothetical protein complement(320524..321690) Staphylococcus aureus subsp. aureus MRSA252 2860285 YP_039741.1 CDS SAR0277 NC_002952.2 321758 323281 R Poor database matches. Similar to N-terminal region of Homo sapiens cylicin I CYLC1 or cyl1 or cyL SW:CYL1_HUMAN (P35663) (598 aa) fasta scores: E(): 6.7e-05, 25.462% id in 487 aa; hypothetical protein complement(321758..323281) Staphylococcus aureus subsp. aureus MRSA252 2860286 YP_039742.1 CDS SAR0278 NC_002952.2 323611 324513 R Similar to Staphylococcus carnosus major secreted protein SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 4.1e-16, 32.932% id in 249 aa, and to Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 8e-17, 31.457% id in 302 aa. C-terminus is similar to SAR2388, 59.821% identity (62.037% ungapped) in 112 aa overlap; hypothetical protein complement(323611..324513) Staphylococcus aureus subsp. aureus MRSA252 2860287 YP_039743.1 CDS SAR0279 NC_002952.2 324752 325045 D Similar to Clostridium acetobutylicum hypothetical protein SW:YHS1_CLOAB (P34159) (96 aa) fasta scores: E(): 2.6e-09, 40.625% id in 96 aa, and to Bacillus halodurans hypothetical protein BH0972 TR:Q9KE84 (EMBL:AP001510) (96 aa) fasta scores: E(): 0.00013, 30.526% id in 95 aa; hypothetical protein 324752..325045 Staphylococcus aureus subsp. aureus MRSA252 2860288 YP_039744.1 CDS SAR0280 NC_002952.2 325128 328157 D Poor database matches. Internal region of the CDS is similar to an internal region of Entamoeba histolytica myosin heavy chain protein MhcA TR:Q07569 (EMBL:L03534) (2139 aa) fasta scores: E(): 0.00025, 21.216% id in 806 aa. Full length CDS is similar to Bacillus subtilis hypothetical protein YueB TR:O32101 (EMBL:Z99120) (1076 aa) fasta scores: E(): 2.8e-08, 20.631% id in 1110 aa; hypothetical protein 325128..328157 Staphylococcus aureus subsp. aureus MRSA252 2860289 YP_039745.1 CDS SAR0281 NC_002952.2 328157 328615 D hypothetical protein 328157..328615 Staphylococcus aureus subsp. aureus MRSA252 2860290 YP_039746.1 CDS SAR0282 NC_002952.2 328587 328829 D Similar to Bacillus subtilis hypothetical protein YukD TR:P71071 (EMBL:Z82015) (79 aa) fasta scores: E(): 0.034, 26.923% id in 78 aa; hypothetical protein 328587..328829 Staphylococcus aureus subsp. aureus MRSA252 2860291 YP_039747.1 CDS SAR0283 NC_002952.2 328842 330176 D Similar to Bacillus subtilis hypothetical protein YukC TR:P71070 (EMBL:Z82015) (451 aa) fasta scores: E(): 2.6e-13, 24.088% id in 411 aa, and to Bacillus halodurans hypothetical protein BH0974 protein bh0974 TR:Q9KE82 (EMBL:AP001510) (440 aa) fasta scores: E(): 5.5e-12, 21.114% id in 431 aa. CDS contains C-terminal hydrophilic domain; hypothetical protein 328842..330176 Staphylococcus aureus subsp. aureus MRSA252 2860292 YP_039748.1 CDS SAR0284 NC_002952.2 330198 334646 D Internal region is similar to Bacillus cereus diarrhoeal toxin BceT TR:P70871 (EMBL:D17312) (366 aa) fasta scores: E(): 2.1e-71, 57.746% id in 355 aa. C-terminal region is similar to Bacillus subtilis hypothetical protein YukA TR:P71068 (EMBL:Z99120) (1207 aa) fasta scores: E(): 2.1e-119, 38.767% id in 1233 aa; hypothetical protein 330198..334646 Staphylococcus aureus subsp. aureus MRSA252 2860293 YP_039749.1 CDS SAR0285 NC_002952.2 334649 334915 D No database matches; hypothetical protein 334649..334915 Staphylococcus aureus subsp. aureus MRSA252 2860294 YP_039750.1 CDS SAR0286 NC_002952.2 334938 335333 D Hydrophilic protein. No significant database matches; hypothetical protein 334938..335333 Staphylococcus aureus subsp. aureus MRSA252 2860295 YP_039751.1 CDS SAR0287 NC_002952.2 335355 337025 D Poor database matches. C-terminal region is similar to the N-terminus of Streptococcus thermophilus bacteriophage Sfi11 minor tail protein TR:O80179 (EMBL:AF158600) (1510 aa) fasta scores: E(): 1.1, 20.200% id in 500 aa; hypothetical protein 335355..337025 Staphylococcus aureus subsp. aureus MRSA252 2860296 YP_039752.1 CDS SAR0288 NC_002952.2 337041 337685 D No significant database matches to the full length CDS. Weakly similar to the N-terminal region of Thermoplasma volcanium hypothetical protein TVG0160586 TR:BAB59293 (EMBL:AP000991) (469 aa) fasta scores: E(): 0.76, 26.154% id in 195 aa; hypothetical protein 337041..337685 Staphylococcus aureus subsp. aureus MRSA252 2860297 YP_039753.1 CDS SAR0289 NC_002952.2 337685 338140 D hypothetical protein 337685..338140 Staphylococcus aureus subsp. aureus MRSA252 2860298 YP_039754.1 CDS SAR0290 NC_002952.2 338160 338591 D hypothetical protein 338160..338591 Staphylococcus aureus subsp. aureus MRSA252 2860299 YP_039755.1 CDS SAR0291 NC_002952.2 338615 339202 D Poor database matches. Similar to internal regions of Archaeoglobus fulgidus quinone oxidoreductase subunit AF1831 TR:O28444 (EMBL:AE000976) (369 aa) fasta scores: E(): 1.3, 24.725% id in 182 aa, and to Enterococcus faecalis peptide antibiotic AS-48 maturation and biosynthesis protein AS-48B TR:O53024 (EMBL:Y12234) (563 aa) fasta scores: E(): 2.3, 26.738% id in 187 aa; hypothetical protein 338615..339202 Staphylococcus aureus subsp. aureus MRSA252 2860300 YP_039756.1 CDS SAR0292 NC_002952.2 339379 339597 D hypothetical protein 339379..339597 Staphylococcus aureus subsp. aureus MRSA252 2860301 YP_039757.1 CDS SAR0293 NC_002952.2 339729 340229 D Similar to Bacillus halodurans hypothetical protein BH3703 TR:Q9K6M5 (EMBL:AP001519) (169 aa) fasta scores: E(): 7.3e-09, 28.659% id in 164 aa, and to C-terminal region of Bacillus subtilis hypothetical protein YeeF TR:O31506 (EMBL:Z99107) (827 aa) fasta scores: E(): 2.9e-10, 27.397% id in 146 aa. Similar to SAR0294, 66.061% identity (66.061% ungapped) in 165 aa overlap and to SAR0295, 72% identity in 157 aa overlap; hypothetical protein 339729..340229 Staphylococcus aureus subsp. aureus MRSA252 2860926 YP_039758.1 CDS SAR0294 NC_002952.2 340240 340740 D Similar to Bacillus halodurans hypothetical protein BH3703 TR:Q9K6M5 (EMBL:AP001519) (169 aa) fasta scores: E(): 3.2e-08, 28.834% id in 163 aa, and to C-terminal region of Bacillus subtilis YeeF hypothetical protein TR:O31506 (EMBL:Z99107) (827 aa) fasta scores: E(): 1e-12, 32.000% id in 150 aa. Similar to SAR0293, 66.061% identity (66.061% ungapped) in 165 aa overlap; hypothetical protein 340240..340740 Staphylococcus aureus subsp. aureus MRSA252 2860927 YP_039759.1 CDS SAR0299 NC_002952.2 342424 342750 D No significant database matches. Truncated at the N-terminus in comparison to N315 and Mu50 orthologues. Possible pseudogene; hypothetical protein 342424..342750 Staphylococcus aureus subsp. aureus MRSA252 2860930 YP_039760.1 CDS SAR0301 NC_002952.2 342884 343282 D hypothetical protein 342884..343282 Staphylococcus aureus subsp. aureus MRSA252 2860931 YP_039761.1 CDS SAR0302 NC_002952.2 343532 344356 R Similar to Staphylococcus carnosus nitrite transporter NirC TR:Q9X2M6 (EMBL:AF029224) (276 aa) fasta scores: E(): 2.3e-42, 43.542% id in 271 aa, and to Bacillus subtilis hypothetical protein Ywcj SW:YWCJ_BACSU (P39608) (256 aa) fasta scores: E(): 6.7e-13, 28.571% id in 245 aa; formate/nitrite transporter complement(343532..344356) Staphylococcus aureus subsp. aureus MRSA252 2860932 YP_039762.1 CDS SAR0303 NC_002952.2 344607 345914 R Similar to Corynebacterium glutamicum branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_CORGL (O06754) (426 aa) fasta scores: E(): 1.3e-45, 38.642% id in 427 aa, and to Bacillus subtilis branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_BACSU (P94499) (440 aa) fasta scores: E(): 1.7e-55, 38.928% id in 429 aa; amino acid transport system complement(344607..345914) Staphylococcus aureus subsp. aureus MRSA252 2860933 YP_039763.1 CDS SAR0304 NC_002952.2 346498 347388 D Similar to Haemophilus influenzae lipoprotein e precursor Hel SW:HEL_HAEIN (P26093) (274 aa) fasta scores: E(): 3e-24, 33.942% id in 274 aa, and to Streptococcus equisimilis cytoplasmic membrane lipoprotein precursor LppC TR:O05471 (EMBL:Y12602) (285 aa) fasta scores: E(): 2.4e-38, 43.448% id in 290 aa; hypothetical protein 346498..347388 Staphylococcus aureus subsp. aureus MRSA252 2860934 YP_039764.1 CDS SAR0305 NC_002952.2 347637 348686 D Similar to Lactococcus lactis hypothetical protein YxeA TR:Q9CDG5 (EMBL:AE006454) (357 aa) fasta scores: E(): 2.3e-47, 44.077% id in 363 aa, and to Deinococcus radiodurans hypothetical protein DRA0279 TR:Q9RYN1 (EMBL:AE001863) (353 aa) fasta scores: E(): 3.6e-29, 31.818% id in 352 aa; hypothetical protein 347637..348686 Staphylococcus aureus subsp. aureus MRSA252 2860935 YP_039765.1 CDS SAR0306 NC_002952.2 348699 349376 D Similar to Escherichia coli lipoprotein releasing system ATP-binding protein LolD SW:LOLD_ECOLI (P75957) (233 aa) fasta scores: E(): 3.8e-22, 37.387% id in 222 aa, and to Lactococcus lactis ABC transporter ATP-binding protein YxeB TR:Q9CDG4 (EMBL:AE006454) (223 aa) fasta scores: E(): 5.5e-38, 58.525% id in 217 aa; ABC transporter ATP-binding protein 348699..349376 Staphylococcus aureus subsp. aureus MRSA252 2860936 YP_039766.1 CDS SAR0307 NC_002952.2 349584 350615 D Similar to Bacillus amyloliquefaciens PTS system, fructose-specific IIBC component FruA SW:PTFB_BACAM (P41029) (304 aa) fasta scores: E(): 1.4e-05, 27.304% id in 293 aa, and to Streptococcus pyogenes regulatory protein SPY0146 TR:Q9A1Q9 (EMBL:AE006484) (339 aa) fasta scores: E(): 8.5e-68, 59.467% id in 338 aa; hypothetical protein 349584..350615 Staphylococcus aureus subsp. aureus MRSA252 2860937 YP_039767.1 CDS SAR0308 NC_002952.2 350958 352076 D Internal region is similar to Exiguobacterium acetylicum guanosine kinase Gsk TR:O24767 (EMBL:AB005149) (303 aa) fasta scores: E(): 4e-09, 26.000% id in 300 aa, Full length CDS is similar to Deinococcus radiodurans PfkB family carbohydrate kinase DR2312 TR:Q9RS15 (EMBL:AE002063) (383 aa) fasta scores: E(): 1.6e-25, 31.389% id in 360 aa. CDS contains an N-terminal helix-turn-helix domain, probable regulatory protein; PfkB family carbohydrate kinase 350958..352076 Staphylococcus aureus subsp. aureus MRSA252 2860938 YP_039768.1 CDS SAR0309 NC_002952.2 352051 352974 D Similar to Escherichia coli hypothetical protein YeiN SW:YEIN_ECOLI (P33025) (312 aa) fasta scores: E(): 5.8e-59, 57.667% id in 300 aa, and to Erwinia chrysanthemi indigoidine systhesis protein IndA TR:Q9L393 (EMBL:AJ277403) (316 aa) fasta scores: E(): 6e-46, 43.478% id in 299 aa; hypothetical protein 352051..352974 Staphylococcus aureus subsp. aureus MRSA252 2860939 YP_039769.1 CDS SAR0310 NC_002952.2 352985 354205 D Similar to Escherichia coli nucleoside permease NupC SW:NUPC_ECOLI (P33031) (400 aa) fasta scores: E(): 7.9e-56, 43.415% id in 410 aa, and to Bacillus halodurans nucleoside transporter BH1446 TR:Q9KCX3 (EMBL:AP001512) (406 aa) fasta scores: E(): 1.6e-38, 32.775% id in 418 aa; nucleoside permease 352985..354205 Staphylococcus aureus subsp. aureus MRSA252 2860940 YP_039770.1 CDS SAR0311 NC_002952.2 354310 355842 R Similar to the N-terminal regions of Rattus norvegicus sodium-dependent multivitamin transporter SMVT SW:SL56_RAT (O70247) (634 aa) fasta scores: E(): 5.9e-33, 27.613% id in 507 aa, and to Homo sapiens sodium-dependent multivitamin transporter SMVT SW:SL56_HUMAN (Q9Y289) (635 aa) fasta scores: E(): 7.8e-32, 26.531% id in 490 aa; sodium:solute symporter family protein complement(354310..355842) Staphylococcus aureus subsp. aureus MRSA252 2860941 YP_039771.1 CDS SAR0312 NC_002952.2 355882 356763 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(355882..356763) Staphylococcus aureus subsp. aureus MRSA252 2860942 YP_039772.1 CDS SAR0313 NC_002952.2 356921 357781 D Similar to Streptomyces coelicolor glucokinase Glk SW:GLK_STRCO (P40184) (317 aa) fasta scores: E(): 8.2e-10, 28.571% id in 287 aa, and to Streptococcus pyogenes glucose kinase SPY0258 TR:Q9A1I4 (EMBL:AE006492) (312 aa) fasta scores: E(): 3.2e-21, 32.986% id in 288 aa; ROK family protein 356921..357781 Staphylococcus aureus subsp. aureus MRSA252 2860943 YP_039773.1 CDS SAR0314 NC_002952.2 358058 358858 R Similar to Escherichia coli transcriptional repressor of rpiB expression, RpiR SW:RPIR_ECOLI (P39266) (296 aa) fasta scores: E(): 9.1e-07, 21.923% id in 260 aa, and to Lactococcus lactis transcriptional regulator YljC TR:Q9CGC1 (EMBL:AE006350) (273 aa) fasta scores: E(): 1.2e-13, 25.092% id in 271 aa; hypothetical protein complement(358058..358858) Staphylococcus aureus subsp. aureus MRSA252 2860944 YP_039774.1 CDS SAR0315 NC_002952.2 358998 359666 D Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 358998..359666 Staphylococcus aureus subsp. aureus MRSA252 2860945 YP_039775.1 CDS SAR0316 NC_002952.2 359792 361105 R Similar to Vibrio cholerae hypothetical protein VCA0076 TR:Q9KN89 (EMBL:AE004350) (458 aa) fasta scores: E(): 9.5e-32, 29.345% id in 443 aa, and to Bacillus firmus hypothetical protein YkaA SW:YKAA_BACFI (P30267) (463 aa) fasta scores: E(): 1.6e-32, 29.318% id in 440 aa; hypothetical protein complement(359792..361105) Staphylococcus aureus subsp. aureus MRSA252 2860946 YP_039776.1 CDS geh NC_002952.2 361522 363597 D Similar to Staphylococcus aureus lipase (glycerol ester hydrolase) precursor Geh SW:LIP_STAAU (P10335) (690 aa) fasta scores: E(): 0, 97.829% id in 691 aa, and to Staphylococcus epidermidis lipase precursor GehD TR:Q9Z4M7 (EMBL:AF090142) (643 aa) fasta scores: E(): 1.1e-83, 44.250% id in 687 aa; lipase precursor 361522..363597 Staphylococcus aureus subsp. aureus MRSA252 2859913 YP_039777.1 CDS SAR0318 NC_002952.2 363839 364666 R Poor database matches. Similar to Rhodococcus sp hydroxymuconic-semialdehyde hydrolase OhpC TR:Q9KH20 (EMBL:AF274045) (289 aa) fasta scores: E(): 0.51, 23.507% id in 268 aa; hypothetical protein complement(363839..364666) Staphylococcus aureus subsp. aureus MRSA252 2860947 YP_039778.1 CDS SAR0319 NC_002952.2 364724 365938 R N-terminus is similar to the N-terminal region of Thermoanaerobacter brockii NADH oxidase SW:NADO_THEBR (P32382) (651 aa) fasta scores: E(): 7.8e-17, 26.554% id in 354 aa. Full length CDS is similar to Streptococcus pyogenes trimethylamine dehydrogenase SPY1219 TR:Q99ZI3 (EMBL:AE006562) (399 aa) fasta scores: E(): 1.1e-92, 56.853% id in 394 aa; NADH:flavin oxidoreductase / NADH oxidase complement(364724..365938) Staphylococcus aureus subsp. aureus MRSA252 2860948 YP_039779.1 CDS SAR0320 NC_002952.2 366246 367247 D Similar to Streptococcus pyogenes hypothetical protein SPY1218 TR:Q99ZI4 (EMBL:AE006562) (332 aa) fasta scores: E(): 1.6e-50, 42.470% id in 332 aa, and to Bacillus subtilis hypothetical protein YwcH SW:YWCH_BACSU (P39606) (333 aa) fasta scores: E(): 6e-39, 38.690% id in 336 aa; luciferase 366246..367247 Staphylococcus aureus subsp. aureus MRSA252 2860949 YP_039780.1 CDS SAR0321 NC_002952.2 367281 367613 D Similar to an internal region of Drosophila melanogaster mitochondrial glycine cleavage system H protein Ppl SW:GCSH_DROME (Q9U616) (165 aa) fasta scores: E(): 4.6e-07, 34.653% id in 101 aa. Full length CDS is similar to Streptococcus pyogenes glycine cleavage system H protein SPY1217 TR:Q99ZI5 (EMBL:AE006562) (110 aa) fasta scores: E(): 4.2e-22, 60.000% id in 110 aa; glycine cleavage H-protein 367281..367613 Staphylococcus aureus subsp. aureus MRSA252 2860950 YP_039781.1 CDS SAR0322 NC_002952.2 367614 368414 D Poor database matches. Similar to Streptococcus pyogenes hypothetical protein SPY1216 TR:Q99ZI6 (EMBL:AE006562) (270 aa) fasta scores: E(): 6.5e-39, 47.280% id in 239 aa. C-terminal region of the CDS is similar to Escherichia coli hypothetical protein TR:P75918 (EMBL:AE000206) (177 aa) fasta scores: E(): 1.9e-15, 37.569% id in 181 aa; hypothetical protein 367614..368414 Staphylococcus aureus subsp. aureus MRSA252 2860951 YP_039782.1 CDS SAR0323 NC_002952.2 368401 369348 D Similar to Streptococcus pyogenes hypothetical protein SPY1215 TR:Q99ZI7 (EMBL:AE006562) (293 aa) fasta scores: E(): 1.6e-70, 63.838% id in 271 aa, and to Mycoplasma pulmonis hypothetical protein MYPU_4420 TR:CAC13615 (EMBL:AL445564) (282 aa) fasta scores: E(): 3.8e-55, 50.379% id in 264 aa; hypothetical protein 368401..369348 Staphylococcus aureus subsp. aureus MRSA252 2860952 YP_039783.1 CDS SAR0324 NC_002952.2 369326 370348 D Similar to Escherichia coli lipoate-protein ligase A LplA SW:LPLA_ECOLI (P32099) (337 aa) fasta scores: E(): 6.6e-17, 28.896% id in 308 aa, and to Streptococcus pyogenes lipoate-protein ligase LplA TR:Q99ZI8 (EMBL:AE006562) (339 aa) fasta scores: E(): 2.9e-84, 62.059% id in 340 aa; lipoate-protein ligase A 369326..370348 Staphylococcus aureus subsp. aureus MRSA252 2860953 YP_039784.1 CDS SAR0325 NC_002952.2 370661 371689 D Similar to Gerbera hybrida dihydroflavonol-4-reductase Dfr SW:DFRA_GERHY (P51105) (366 aa) fasta scores: E(): 1.1e-20, 32.931% id in 331 aa, and to Rhizobium loti probable cinnamoyl-CoA reductase MLL1975 TR:BAB49218 (EMBL:AP002998) (355 aa) fasta scores: E(): 1e-40, 37.681% id in 345 aa; reductase 370661..371689 Staphylococcus aureus subsp. aureus MRSA252 2860954 YP_039785.1 CDS ulaA NC_002952.2 371783 373129 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(371783..373129) Staphylococcus aureus subsp. aureus MRSA252 2860955 YP_039786.1 CDS SAR0327 NC_002952.2 373144 373428 R Similar to Escherichia coli unknown pentitol phosphotransferase enzyme IIB component SgaB SW:PTXB_ECOLI (P39302) (101 aa) fasta scores: E(): 0.18, 29.787% id in 94 aa, and to Escherichia coli hypothetical protein TR:Q9AI23 (EMBL:AF286670) (95 aa) fasta scores: E(): 4.6e-08, 36.082% id in 97 aa; PTS transporter complement(373144..373428) Staphylococcus aureus subsp. aureus MRSA252 2860956 YP_039787.1 CDS SAR0328 NC_002952.2 373430 373873 R Similar to Escherichia coli cryptic mannitol PTS transporter CmtB SW:PTYA_ECOLI (P32058) (147 aa) fasta scores: E(): 4.1e-14, 35.714% id in 140 aa, and to Escherichia coli unknown pentitol phosphotransferase enzyme IIA component SgaA SW:PTXA_ECOLI (P39303) (154 aa) fasta scores: E(): 1.6e-10, 27.273% id in 143 aa; PTS transport system IIA component complement(373430..373873) Staphylococcus aureus subsp. aureus MRSA252 2860957 YP_039788.1 CDS SAR0329 NC_002952.2 373878 375833 R Similar to Bacillus subtilis cel operon regulator CelR SW:CELR_BACSU (P46321) (641 aa) fasta scores: E(): 3.3e-35, 28.063% id in 506 aa, and to Streptococcus pyogenes transcriptional antiterminator SPY1325 TR:Q99Z99 (EMBL:AE006571) (664 aa) fasta scores: E(): 3.2e-23, 22.430% id in 642 aa; PTS regulator complement(373878..375833) Staphylococcus aureus subsp. aureus MRSA252 2861654 YP_039789.1 CDS SAR0330 NC_002952.2 376045 376464 D Similar to Erwinia carotovora antibiotic production and exoenzyme virulence determinants regulatory protein, Hor SW:HOR_ERWCA (Q9RB09) (145 aa) fasta scores: E(): 0.0022, 26.357% id in 129 aa, and to Lactococcus lactis transcriptional regulator RmaE TR:Q9CFJ4 (EMBL:AE006378) (139 aa) fasta scores: E(): 2.7e-10, 29.851% id in 134 aa; MarR family regulatory protein 376045..376464 Staphylococcus aureus subsp. aureus MRSA252 2861655 YP_039790.1 CDS SAR0331 NC_002952.2 376571 377926 D Similar to Lactococcus lactis hypothetical protein YpbC TR:Q9CFJ2 (EMBL:AE006378) (459 aa) fasta scores: E(): 9.6e-53, 38.636% id in 440 aa, and to Thermotoga maritima conserved hypothetical protein TM1701 TR:Q9X227 (EMBL:AE001810) (458 aa) fasta scores: E(): 1.4e-27, 29.787% id in 423 aa; hypothetical protein 376571..377926 Staphylococcus aureus subsp. aureus MRSA252 2861656 YP_039791.1 CDS SAR0332 NC_002952.2 378032 378472 D Poor database matches. Similar to an internal region of Borrelia burgdorferi lipoprotein TR:Q44816 (EMBL:U45424) (203 aa) fasta scores: E(): 9.9, 28.571% id in 133 aa; hypothetical protein 378032..378472 Staphylococcus aureus subsp. aureus MRSA252 2861657 YP_039792.1 CDS glpT NC_002952.2 378556 379914 R Similar to Bacillus subtilis glycerol-3-phosphate transporter GlpT SW:GLPT_BACSU (P37948) (444 aa) fasta scores: E(): 1.2e-112, 61.863% id in 451 aa, and to Pseudomonas aeruginosa glycerol-3-phosphate transporter GlpT TR:Q9HTV5 (EMBL:AE004936) (448 aa) fasta scores: E(): 1.3e-103, 60.091% id in 441 aa; glycerol-3-phosphate transporter complement(378556..379914) Staphylococcus aureus subsp. aureus MRSA252 2859929 YP_039793.1 CDS SAR0334 NC_002952.2 380226 381152 D Similar to Sphingomonas chlorophenolica 2,6-dichloro-p-hydroxyquinone chlorohydrolase PcpA TR:Q9ZBB0 (EMBL:M55159) (320 aa) fasta scores: E(): 9.2e-13, 26.625% id in 323 aa, and to Bacillus subtilis dioxygenase YkcA TR:O34689 (EMBL:Z99110) (316 aa) fasta scores: E(): 3.5e-40, 37.812% id in 320 aa; dioxygenase 380226..381152 Staphylococcus aureus subsp. aureus MRSA252 2861658 YP_039794.1 CDS SAR0335 NC_002952.2 381166 382227 D Similar to Vibrio fischeri alkanal monooxygenase alpha chain protein LuxA TR:Q9S3Z1 (EMBL:AF170104) (354 aa) fasta scores: E(): 7.1e-07, 22.515% id in 342 aa, and to Bacillus amyloliquefaciens hypothetical protein TR:Q9F9Q6 (EMBL:AF181997) (356 aa) fasta scores: E(): 1.8e-55, 45.115% id in 348 aa; luciferase-like monooxygenase 381166..382227 Staphylococcus aureus subsp. aureus MRSA252 2861659 YP_039795.1 CDS SAR0338 NC_002952.2 382867 383862 R Similar to Escherichia coli hypothetical protein YeiH SW:YEIH_ECOLI (P33019) (349 aa) fasta scores: E(): 1.6e-28, 32.381% id in 315 aa, and to Rhizobium loti hypothetical protein MlR2225 TR:BAB49407 (EMBL:AP002999) (325 aa) fasta scores: E(): 9.1e-28, 28.616% id in 318 aa; hypothetical protein complement(382867..383862) Staphylococcus aureus subsp. aureus MRSA252 2861661 YP_039796.1 CDS SAR0339 NC_002952.2 384222 384767 D Similar to Escherichia coli ribosomal-protein-serine acetyltransferase RimL SW:RIML_ECOLI (P13857) (179 aa) fasta scores: E(): 1.2e-13, 29.586% id in 169 aa, and to Bacillus subtilis probable acetyltransferase YdaF TR:P96579 (EMBL:AB001488) (183 aa) fasta scores: E(): 1.2e-26, 45.405% id in 185 aaSimilar to SAR0718, 68.085% identity (68.085% ungapped) in 329 aa overlap; acetyltransferase 384222..384767 Staphylococcus aureus subsp. aureus MRSA252 2861662 YP_039797.1 CDS SAR0340 NC_002952.2 385032 385886 D Similar to the C-terminal regions of Streptomyces coelicolor lipoprotein SCC75A.21 TR:Q9RKQ3 (EMBL:AL133220) (384 aa) fasta scores: E(): 2.1e-32, 44.361% id in 266 aa, and Bacillus subtilis hypothetical protein YwbM SW:YWBM_BACSU (P39596) (385 aa) fasta scores: E(): 1.9e-28, 42.353% id in 255 aa; lipoprotein 385032..385886 Staphylococcus aureus subsp. aureus MRSA252 2861663 YP_039798.1 CDS SAR0341 NC_002952.2 385883 387112 D Similar to Bacillus subtilis hypothetical protein SW:YWBN_BACSU (P39597) (416 aa) fasta scores: E(): 1.6e-40, 40.338% id in 414 aa, and to Streptomyces coelicolor membrane protein SCC75A.22 TR:Q9RKQ2 (EMBL:AL133220) (420 aa) fasta scores: E(): 4.4e-40, 40.793% id in 429 aa; Sec-independent exported protein 385883..387112 Staphylococcus aureus subsp. aureus MRSA252 2861664 YP_039799.1 CDS SAR0342 NC_002952.2 387093 388805 D Similar to the C-terminal regions of Pasteurella multocida hypothetical protein PM0453 TR:Q9CNH8 (EMBL:AE006081) (634 aa) fasta scores: E(): 3.3e-18, 23.304% id in 575 aa, and Campylobacter jejuni integral membrane protein CJ1658 TR:Q9PM19 (EMBL:AL139079) (696 aa) fasta scores: E(): 2.1e-16, 25.497% id in 604 aa; hypothetical protein 387093..388805 Staphylococcus aureus subsp. aureus MRSA252 2861665 YP_039800.1 CDS SAR0343 NC_002952.2 389116 389817 R Similar to Escherichia coli Sec-independent protein translocase TatC or MttB SWALL:TATC_ECOLI (SWALL:P27857) (258 aa) fasta scores: E(): 2e-15, 30.17% id in 232 aa, and to Bacillus halodurans hypothetical protein BH0553 SW:YDIJ_BACHD (Q9Z9P4) (253 aa) fasta scores: E(): 2.2e-27, 37.229% id in 231 aa; Sec-independent protein translocase complement(389116..389817) Staphylococcus aureus subsp. aureus MRSA252 2861666 YP_039801.1 CDS SAR0344 NC_002952.2 389834 390049 R Similar to the N-terminal region of Escherichia coli Sec-independent protein translocase TatA or MttA1 SWALL:TATA_ECOLI (SWALL:O65938) (89 aa) fasta scores: E(): 0.048, 36% id in 50 aa. Full length CDS is similar to Bacillus halodurans hypothetical protein BH3905 TR:Q9K627 (EMBL:AP001520) (68 aa) fasta scores: E(): 1.3e-07, 56.250% id in 64 aa; Sec-independent protein translocase complement(389834..390049) Staphylococcus aureus subsp. aureus MRSA252 2861667 YP_039802.1 CDS SAR0345 NC_002952.2 390157 390546 R Poor database matches. Similar to Lactococcus lactis hypothetical protein YcfH TR:Q9CIU6 (EMBL:AE006263) (137 aa) fasta scores: E(): 0.19, 26.400% id in 125 aa; hypothetical protein complement(390157..390546) Staphylococcus aureus subsp. aureus MRSA252 2861668 YP_039803.1 CDS SAR0346 NC_002952.2 390786 390989 D Similar to Streptococcus pyogenes transcriptional regulator protein SPY1386 TR:Q99Z58 (EMBL:AE006576) (71 aa) fasta scores: E(): 1.3e-14, 65.672% id in 67 aa, and to Archaeoglobus fulgidus hypothetical transcriptional regulator AF1627 SW:YG27_ARCFU (O28646) (71 aa) fasta scores: E(): 1.2e-09, 47.761% id in 67 aa; DNA-binding protein 390786..390989 Staphylococcus aureus subsp. aureus MRSA252 2861669 YP_039804.1 CDS SAR0347 NC_002952.2 390986 391699 D Similar to Streptococcus pyogenes hypothetical protein SPY1385 TR:Q99Z59 (EMBL:AE006576) (253 aa) fasta scores: E(): 1, 23.016% id in 252 aa, and to an internal region of Bacillus halodurans hypothetical protein BH1986 TR:Q9KBE2 (EMBL:AP001513) (439 aa) fasta scores: E(): 3.5, 27.556% id in 225 aa; hypothetical protein 390986..391699 Staphylococcus aureus subsp. aureus MRSA252 2861670 YP_039805.1 CDS SAR0348 NC_002952.2 391724 392566 D Similar to Bacillus subtilis ATP-binding transport protein NatA SW:NATA_BACSU (P46903) (246 aa) fasta scores: E(): 1.6e-11, 28.854% id in 253 aa, and to Bacillus halodurans ABC transporter BH0652 TR:Q9KF34 (EMBL:AP001509) (288 aa) fasta scores: E(): 4.6e-20, 33.083% id in 266 aa; ABC transporter ATP-binding protein 391724..392566 Staphylococcus aureus subsp. aureus MRSA252 2861671 YP_039806.1 CDS SAR0349 NC_002952.2 392566 393195 D Similar to Staphylococcus xylosus hypothetical protein TR:O33816 (EMBL:Y14599) (209 aa) fasta scores: E(): 8.7e-32, 48.357% id in 213 aa, and to Butyrivibrio fibrisolvens butyrivibriocin AR10 operon protein BviB TR:Q9ZGP7 (EMBL:AF076529) (216 aa) fasta scores: E(): 0.033, 22.667% id in 225 aa; hypothetical protein 392566..393195 Staphylococcus aureus subsp. aureus MRSA252 2861672 YP_039807.1 CDS SAR0350 NC_002952.2 393564 394697 R Poor database matches. C-terminus is similar to Listeria monocytogenes low temperature requirement protein A LtrA TR:Q9ZIM4 (EMBL:AF023180) (324 aa) fasta scores: E(): 2.9e-11, 25.387% id in 323 aa. Full length CDS is similar to C-terminal region of Rhizobium meliloti hypothetical protein SW:YSY3_RHIME (O33683) (451 aa) fasta scores: E(): 0.00015, 21.180% id in 373 aa; hypothetical protein complement(393564..394697) Staphylococcus aureus subsp. aureus MRSA252 2861673 YP_039808.1 CDS thl NC_002952.2 395237 396418 D Similar to Clostridium acetobutylicum acetyl-CoA acetyltransferase Thl SW:THL_CLOAB (P45359) (392 aa) fasta scores: E(): 5e-81, 57.653% id in 392 aa, and to Clostridium thermosaccharolyticum acetyl coenzyme A acetyltransferase ThlA TR:P77852 (EMBL:Z82038) (392 aa) fasta scores: E(): 1.1e-82, 58.929% id in 392 aa; acetyl-CoA acetyltransferase 395237..396418 Staphylococcus aureus subsp. aureus MRSA252 2859529 YP_039809.1 CDS SAR0352 NC_002952.2 396501 397253 R Similar to Pasteurella multocida hypothetical protein PM0097 TR:Q9CPE7 (EMBL:AE006045) (247 aa) fasta scores: E(): 7.6e-50, 51.867% id in 241 aa, and to Rhizobium loti hypothetical protein MLR5444 TR:BAB51895 (EMBL:AP003006) (263 aa) fasta scores: E(): 3.3e-19, 32.500% id in 240 aa; hypothetical protein complement(396501..397253) Staphylococcus aureus subsp. aureus MRSA252 2861674 YP_039810.1 CDS metE NC_002952.2 397296 399524 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase complement(397296..399524) Staphylococcus aureus subsp. aureus MRSA252 2861162 YP_039811.1 CDS SAR0354 NC_002952.2 399521 401362 R catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions; bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase complement(399521..401362) Staphylococcus aureus subsp. aureus MRSA252 2861675 YP_039812.1 CDS SAR0355 NC_002952.2 401331 402491 R Similar to Lactococcus lactis (subsp. cremoris) (Streptococcus cremoris) cystathionine beta-lyase MetC TR:Q9RAS9 (EMBL:AF131880) (380 aa) fasta scores: E(): 8e-61, 47.887% id in 355 aa, and to Lactobacillus reuteri cystathionine beta-lyase TR:Q9FCU8 (EMBL:AJ293860) (380 aa) fasta scores: E(): 8.2e-66, 49.304% id in 359 aa; Cys/Met metabolism PLP-dependent enzyme complement(401331..402491) Staphylococcus aureus subsp. aureus MRSA252 2861676 YP_039813.1 CDS SAR0356 NC_002952.2 402488 403591 R Similar to Lactococcus lactis (subsp. cremoris) (Streptococcus cremoris) cystathionine beta-lyase MetC TR:Q9RAS9 (EMBL:AF131880) (380 aa) fasta scores: E(): 3.6e-39, 41.096% id in 365 aa, and to Bacillus subtilis hypothetical protein YjcI TR:O31631 (EMBL:Z99110) (373 aa) fasta scores: E(): 2e-66, 49.863% id in 365 aa; Cys/Met metabolism PLP-dependent enzyme complement(402488..403591) Staphylococcus aureus subsp. aureus MRSA252 2861677 YP_039814.1 CDS SAR0357 NC_002952.2 404255 405100 D Similar to Bacillus subtilis stage 0 sporulation protein T Spo0J SW:SP0J_BACSU (P26497) (282 aa) fasta scores: E(): 1.3e-37, 45.802% id in 262 aa, and to Listeria monocytogenes hypothetical protein ParB TR:Q9FCV8 (EMBL:AJ010494) (283 aa) fasta scores: E(): 1.3e-40, 49.811% id in 265 aa; DNA-binding protein 404255..405100 Staphylococcus aureus subsp. aureus MRSA252 2861678 YP_039815.1 CDS SAR0358 NC_002952.2 405254 406135 D Similar to Bacillus halodurans hypothetical protein BH2666 TR:Q9K9I1 (EMBL:AP001516) (276 aa) fasta scores: E(): 9.8e-26, 34.815% id in 270 aa, and to Bacillus subtilis hypothetical protein YkuT TR:O34897 (EMBL:AJ222587) (267 aa) fasta scores: E(): 2.4e-22, 35.772% id in 246 aa; hypothetical protein 405254..406135 Staphylococcus aureus subsp. aureus MRSA252 2861679 YP_039816.1 CDS SAR0359 NC_002952.2 406165 406368 D Similar to Bacillus halodurans hypothetical protein BH4052 TR:Q9K5N6 (EMBL:AP001520) (65 aa) fasta scores: E(): 6.3e-13, 54.237% id in 59 aa, and to Streptococcus pyogenes hypothetical protein SPY0004 TR:Q9A208 (EMBL:AE006472) (65 aa) fasta scores: E(): 4.4e-09, 50.000% id in 62 aa; hypothetical protein 406165..406368 Staphylococcus aureus subsp. aureus MRSA252 2861680 YP_039817.1 CDS SAR0360 NC_002952.2 406380 407477 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 406380..407477 Staphylococcus aureus subsp. aureus MRSA252 2861681 YP_039818.1 CDS SAR0361 NC_002952.2 407563 407754 R hypothetical protein complement(407563..407754) Staphylococcus aureus subsp. aureus MRSA252 2861682 YP_039819.1 CDS rpsF NC_002952.2 407998 408294 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 407998..408294 Staphylococcus aureus subsp. aureus MRSA252 2860177 YP_039820.1 CDS ssb NC_002952.2 408315 408818 D Similar to Bacillus subtilis single-strand binding protein Ssb SW:SSB_BACSU (P37455) (172 aa) fasta scores: E(): 7.6e-40, 67.429% id in 175 aa, and to bacteriophage A118 single-strand binding protein Ssb protein TR:Q9T160 (EMBL:AJ242593) (160 aa) fasta scores: E(): 8.1e-35, 59.281% id in 167 aa. Similar to SAR2083, 68.862% identity (73.718% ungapped) in 167 aa overlap; single-strand DNA-binding protein 408315..408818 Staphylococcus aureus subsp. aureus MRSA252 2859505 YP_039821.1 CDS rpsR NC_002952.2 408870 409112 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 408870..409112 Staphylococcus aureus subsp. aureus MRSA252 2861454 YP_039822.1 CDS SAR0365 NC_002952.2 409344 410063 R Poor database matches. Similar to the C-terminal regions of Streptococcus pyogenes conserved hypothetical protein-phage associated protein SPY0938 TR:Q9A043 (EMBL:AE006542) (269 aa) fasta scores: E(): 4.1e-09, 30.638% id in 235 aa, and to Cryptosporidium parvum hypothetical protein TR:Q9GRY1 (EMBL:AJ293269) (483 aa) fasta scores: E(): 7.5, 25.941% id in 239 aa; hypothetical protein complement(409344..410063) Staphylococcus aureus subsp. aureus MRSA252 2861683 YP_039823.1 CDS SAR0366 NC_002952.2 410176 411390 R Similar to bacteriophage phi PVL, and Staphylococcus aureus temperate phage phiSLT, integrase TR:O80068 (EMBL:AB009866) (401 aa) fasta scores: E(): 2e-52, 38.765% id in 405 aa, and to bacteriophage bIL312 integrase Int TR:Q9AZF9 (EMBL:AF323673) (382 aa) fasta scores: E(): 1e-15, 35.468% id in 406 aa; integrase complement(410176..411390) Staphylococcus aureus subsp. aureus MRSA252 2861684 YP_039824.1 CDS SAR0367 NC_002952.2 411551 412174 R Similar to bacteriophage bIL311 cI-like repressor TR:Q9AZH9 (EMBL:AF323672) (235 aa) fasta scores: E(): 1.9, 25.822% id in 213 aa, and to Staphylococcus aureus pathogenicity island protein Orf20 TR:Q9F0J8 (EMBL:AF217235) (267 aa) fasta scores: E(): 1.4, 26.961% id in 204 aa; DNA-binding protein complement(411551..412174) Staphylococcus aureus subsp. aureus MRSA252 2861685 YP_039825.1 CDS SAR0368 NC_002952.2 412269 412487 D Similar to bacteriophage SPP1 hypothetical protein Orf37.3 TR:Q38149 (EMBL:X67865) (57 aa) fasta scores: E(): 2.7, 27.660% id in 47 aa, and to Streptomyces coelicolor hypothetical protein SCE68.26C TR:Q9WX06 (EMBL:AL079345) (70 aa) fasta scores: E(): 0.5, 29.091% id in 55 aa; DNA-binding protein 412269..412487 Staphylococcus aureus subsp. aureus MRSA252 2861223 YP_039826.1 CDS SAR0369 NC_002952.2 412488 412760 D Similar to bacteriophage phi PVL hypothetical protein Orf37 TR:O80076 (EMBL:AB009866) (87 aa) fasta scores: E(): 2.3e-07, 37.079% id in 89 aa, and to Staphylococcus aureus temperate phage phiSLT hypothetical protein TR:Q9B0G8 (EMBL:AB045978) (87 aa) fasta scores: E(): 2.6e-06, 33.708% id in 89 aa; hypothetical protein 412488..412760 Staphylococcus aureus subsp. aureus MRSA252 2861224 YP_039827.1 CDS SAR0370 NC_002952.2 412772 412945 D hypothetical protein 412772..412945 Staphylococcus aureus subsp. aureus MRSA252 2861225 YP_039828.1 CDS SAR0371 NC_002952.2 412912 413058 D hypothetical protein 412912..413058 Staphylococcus aureus subsp. aureus MRSA252 2861226 YP_039829.1 CDS SAR0372 NC_002952.2 413116 413499 D Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf17 TR:Q9F0K1 (EMBL:AF217235) (127 aa) fasta scores: E(): 4.9e-47, 98.425% id in 127 aa; hypothetical protein 413116..413499 Staphylococcus aureus subsp. aureus MRSA252 2861227 YP_039830.1 CDS SAR0373 NC_002952.2 413500 413826 D Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf16 TR:Q9F0K2 (EMBL:AF217235) (105 aa) fasta scores: E(): 3.2e-14, 45.370% id in 108 aa; hypothetical protein 413500..413826 Staphylococcus aureus subsp. aureus MRSA252 2861228 YP_039831.1 CDS SAR0374 NC_002952.2 413891 414760 D Similar to Lactococcus bacteriophage phi31 hypothetical protein TR:Q9G0E4 (EMBL:AJ292531) (268 aa) fasta scores: E(): 0.0017, 21.961% id in 255 aa, and to Staphylococcus aureus pathogenicity island protein Orf15 TR:Q9F0K3 (EMBL:AF217235) (289 aa) fasta scores: E(): 1.3e-116, 95.502% id in 289 aa; hypothetical protein 413891..414760 Staphylococcus aureus subsp. aureus MRSA252 2861229 YP_039832.1 CDS SAR0375 NC_002952.2 414774 416483 D Poor database matches. N-terminus is similar to Staphylococcus aureus pathogenicity island protein Orf14 TR:Q9F0K4 (EMBL:AF217235) (278 aa) fasta scores: E(): 4.9e-95, 98.545% id in 275 aa. and C-terminus is similar to Staphylococcus aureus pathogenicity island protein Orf13 TR:Q9F0K5 (EMBL:AF217235) (293 aa) fasta scores: E(): 4.5e-94, 89.273% id in 289 aa; hypothetical protein 414774..416483 Staphylococcus aureus subsp. aureus MRSA252 2861230 YP_039833.1 CDS SAR0376 NC_002952.2 416793 417173 D Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf12 TR:Q9F0K6 (EMBL:AF217235) (126 aa) fasta scores: E(): 1.3e-49, 96.825% id in 126 aa; hypothetical protein 416793..417173 Staphylococcus aureus subsp. aureus MRSA252 2861231 YP_039834.1 CDS SAR0377 NC_002952.2 417170 417811 D Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf11 TR:Q9F0K7 (EMBL:AF217235) (213 aa) fasta scores: E(): 8.4e-76, 93.897% id in 213 aa; hypothetical protein 417170..417811 Staphylococcus aureus subsp. aureus MRSA252 2861232 YP_039835.1 CDS SAR0378 NC_002952.2 418519 418863 D Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf10 TR:Q9F0K8 (EMBL:AF217235) (113 aa) fasta scores: E(): 8.4e-38, 91.667% id in 108 aa; hypothetical protein 418519..418863 Staphylococcus aureus subsp. aureus MRSA252 2861233 YP_039836.1 CDS SAR0379 NC_002952.2 418894 419547 D Poor database matches. Similar to Plasmodium falciparum hypothetical protein PFC0075c TR:O97331 (EMBL:AL034560) (284 aa) fasta scores: E(): 1.7, 26.154% id in 195 aa; hypothetical protein 418894..419547 Staphylococcus aureus subsp. aureus MRSA252 2861234 YP_039837.1 CDS SAR0380 NC_002952.2 419600 420127 D Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf7 TR:Q9F0L1 (EMBL:AF217235) (191 aa) fasta scores: E(): 7.7e-61, 96.000% id in 175 aa. CDS is truncated at the C-terminus in comparison to the pathogenicity island protein; hypothetical protein 419600..420127 Staphylococcus aureus subsp. aureus MRSA252 2861235 YP_039838.1 CDS SAR0381 NC_002952.2 420130 420471 D Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf6 TR:Q9F0L2 (EMBL:AF217235) (113 aa) fasta scores: E(): 2.4e-40, 93.805% id in 113 aa; hypothetical protein 420130..420471 Staphylococcus aureus subsp. aureus MRSA252 2861236 YP_039839.1 CDS SAR0382 NC_002952.2 420468 421037 D Similar to bacteriophage SF6, and bacteriophage rho-15 terminase small subunit SW:TERS_BPSF6 (Q38627) (151 aa) fasta scores: E(): 8.6e-06, 34.568% id in 162 aa, and to Staphylococcus aureus pathogenicity island protein Orf5 TR:Q9F0L3 (EMBL:AF217235) (189 aa) fasta scores: E(): 6.2e-67, 97.884% id in 189 aa; terminase small subunit 420468..421037 Staphylococcus aureus subsp. aureus MRSA252 2861237 YP_039840.2 CDS SAR0383 NC_002952.2 421314 422282 D No significant database matches to the full length CDS. C-terminus is similar to C-terminal region of Lactococcus lactis plasmid (pNP40) abortive bacteriophage infection protein AbiF TR:Q48618 (EMBL:U36837) (342 aa) fasta scores: E(): 0.00068, 22.857% id in 280 aa. N-terminus is similar to N-terminal region of Pasteurella multocida hypothetical protein PM1540 TR:Q9CKR6 (EMBL:AE006190) (309 aa) fasta scores: E(): 1.3e-08, 24.731% id in 279 aa; hypothetical protein 421314..422282 Staphylococcus aureus subsp. aureus MRSA252 2861238 YP_039841.1 CDS SAR0384 NC_002952.2 422460 422861 D Poor database matches. Similar to an internal region of Streptococcus thermophilus bacteriophage 7201 hypothetical protein Orf2 TR:Q9MCM9 (EMBL:AF145054) (175 aa) fasta scores: E(): 1.8e-08, 36.290% id in 124 aa; hypothetical protein 422460..422861 Staphylococcus aureus subsp. aureus MRSA252 2861239 YP_039842.1 CDS SAR0385 NC_002952.2 422979 423491 D Poor database matches. Similar to Staphylococcus aureus pathogenicity island protein Orf3 TR:Q9F0L5 (EMBL:AF217235) (170 aa) fasta scores: E(): 1.3e-50, 99.412% id in 170 aa; hypothetical protein 422979..423491 Staphylococcus aureus subsp. aureus MRSA252 2861240 YP_039843.1 CDS SAR0386 NC_002952.2 424449 425456 R Poor database matches. Weakly similar to Pasteurella multocida hypothetical protein PM1540 TR:Q9CKR6 (EMBL:AE006190) (309 aa) fasta scores: E(): 9.9, 22.101% id in 276 aa; hypothetical protein complement(424449..425456) Staphylococcus aureus subsp. aureus MRSA252 2861241 YP_039844.1 CDS SAR0389 NC_002952.2 426413 426781 D Similar to Bacillus subtilis hypothetical protein YxeA SW:YXEA_BACSU (P54940) (115 aa) fasta scores: E(): 2.7e-06, 29.091% id in 110 aa, and to Lactococcus lactis hypothetical protein YpaG TR:Q9CFJ9 (EMBL:AE006378) (115 aa) fasta scores: E(): 9e-05, 31.405% id in 121 aa; hypothetical protein 426413..426781 Staphylococcus aureus subsp. aureus MRSA252 2861243 YP_039845.1 CDS SAR0390 NC_002952.2 426962 427534 D Similar to Campylobacter jejuni acidic periplasmic protein CJ0424 TR:Q9PI81 (EMBL:AL139075) (210 aa) fasta scores: E(): 0.93, 25.500% id in 200 aa. C-terminus is similar to the C-terminal region of Bacillus subtilis hypothetical protein YkoI TR:O34551 (EMBL:AJ002571) (226 aa) fasta scores: E(): 0.29, 24.138% id in 145 aa; hypothetical protein 426962..427534 Staphylococcus aureus subsp. aureus MRSA252 2860894 YP_039846.1 CDS SAR0391 NC_002952.2 427672 427935 R Poor database matches. Similar to the N-terminal region of Lactococcus lactis transcriptional regulator YnaB TR:Q9CG39 (EMBL:AE006359) (252 aa) fasta scores: E(): 4.3, 27.273% id in 77 aa; hypothetical protein complement(427672..427935) Staphylococcus aureus subsp. aureus MRSA252 2860454 YP_039847.1 CDS SAR0392 NC_002952.2 428229 428483 D Similar to Bacillus subtilis hypothetical protein YdaS TR:P96594 (EMBL:AB001488) (85 aa) fasta scores: E(): 9.2e-11, 46.429% id in 84 aa, and to Lactococcus lactis hypothetical protein YmgJ TR:Q9CG68 (EMBL:AE006356) (80 aa) fasta scores: E(): 6.6e-08, 46.479% id in 71 aa; hypothetical protein 428229..428483 Staphylococcus aureus subsp. aureus MRSA252 2860455 YP_039848.1 CDS SAR0393 NC_002952.2 428522 428731 R No significant database matches. Doubtful CDS; hypothetical protein complement(428522..428731) Staphylococcus aureus subsp. aureus MRSA252 2860456 YP_039849.1 CDS SAR0394 NC_002952.2 428909 429490 D Similar to Schizosaccharomyces pombe phosphoglycerate mutase SPAC26F1.06 SW:PMGY_SCHPO (P36623) (211 aa) fasta scores: E(): 3.7e-05, 25.000% id in 196 aa, and to Rhizobium loti phosphoglycerate mutase MLR4643 TR:BAB51251 (EMBL:AP003004) (206 aa) fasta scores: E(): 3.2e-07, 29.146% id in 199 aa; phosphoglycerate mutase 428909..429490 Staphylococcus aureus subsp. aureus MRSA252 2860457 YP_039850.1 CDS SAR0395 NC_002952.2 429556 429939 R Similar to Bacillus subtilis hypothetical protein YdeH TR:P96665 (EMBL:AB001488) (148 aa) fasta scores: E(): 0.00021, 27.344% id in 128 aa. CDS is truncated at the N-terminus in comparison to B. subtilis protein; hypothetical protein complement(429556..429939) Staphylococcus aureus subsp. aureus MRSA252 2860458 YP_039851.1 CDS SAR395a NC_002952.2 430027 430134 D No significant database matches. Doubtful CDS; hypothetical protein 430027..430134 Staphylococcus aureus subsp. aureus MRSA252 2859050 YP_039852.1 CDS SAR0396 NC_002952.2 430210 430836 R Similar to Bacillus subtilis hypothetical protein YkyA SW:YKYA_BACSU (P21884) (237 aa) fasta scores: E(): 0.71, 23.077% id in 221 aa, and to Bacillus subtilis hypothetical protein YkyA TR:Q45496 (EMBL:AF012285) (205 aa) fasta scores: E(): 4.1, 22.927% id in 205 aa; hypothetical protein complement(430210..430836) Staphylococcus aureus subsp. aureus MRSA252 2860459 YP_039853.1 CDS SAR0397 NC_002952.2 430909 432528 R Similar to an internal region of Amsacta moorei entomopoxvirus hypothetical protein AMV156 TR:Q9EMP3 (EMBL:AF250284) (1238 aa) fasta scores: E(): 0.81, 19.540% id in 522 aa. Internal region of the CDS is similar to N-terminal region of bacteriophage SPBc2 hypothetical protein YolJ TR:O64036 (EMBL:AF020713) (422 aa) fasta scores: E(): 0.98, 20.323% id in 310 aa; hypothetical protein complement(430909..432528) Staphylococcus aureus subsp. aureus MRSA252 2860460 YP_039854.1 CDS ahpF NC_002952.2 432643 434166 R Similar to Xanthomonas campestris alkyl hydroperoxide reductase subunit F AhpF SW:AHPF_XANCH (O06465) (530 aa) fasta scores: E(): 1.8e-95, 53.876% id in 516 aa. Previously sequenced as Staphylococcus aureus alkyl hydroperoxide reductase subunit F AhpF SW:AHPF_STAAU (O05204) (507 aa) fasta scores: E(): 2.9e-181, 98.817% id in 507 aa; alkyl hydroperoxide reductase subunit F complement(432643..434166) Staphylococcus aureus subsp. aureus MRSA252 2860986 YP_039855.1 CDS ahpC NC_002952.2 434182 434751 R Similar to Salmonella typhimurium alkyl hydroperoxide reductase, C22 protein, AhpC SW:AHPC_SALTY (P19479) (186 aa) fasta scores: E(): 5.2e-47, 65.426% id in 188 aa. Previously sequenced as Staphylococcus aureus, and alkyl hydroperoxide reductase subunit C AhpC TR:Q53647 (EMBL:U92441) (189 aa) fasta scores: E(): 5.1e-74, 100.000% id in 189 aa; alkyl hydroperoxide reductase subunit C complement(434182..434751) Staphylococcus aureus subsp. aureus MRSA252 2860985 YP_039856.1 CDS SAR0400 NC_002952.2 435242 435997 D Similar to Vibrio harveyi NADPH-flavin oxidoreductase Frp SW:FRP_VIBHA (Q56691) (240 aa) fasta scores: E(): 2.8e-28, 36.400% id in 250 aa, and to Bacillus subtilis nitro/flavin reductase NfrA SW:NFRA_BACSU (P39605) (249 aa) fasta scores: E(): 8e-37, 42.105% id in 247 aa; nitroreductase 435242..435997 Staphylococcus aureus subsp. aureus MRSA252 2860461 YP_039857.1 CDS SAR0401 NC_002952.2 436077 437465 R Similar to Escherichia coli proton glutamate symport protein GltP SW:GLTP_ECOLI (P21345) (437 aa) fasta scores: E(): 2.4e-22, 25.459% id in 436 aa, and to Bacillus subtilis hypothetical symporter YhcL SW:YHCL_BACSU (P54596) (463 aa) fasta scores: E(): 1.8e-102, 61.283% id in 452 aa; sodium:dicarboxylate symporter protein complement(436077..437465) Staphylococcus aureus subsp. aureus MRSA252 2860462 YP_039858.1 CDS SAR0401a NC_002952.2 437550 437651 D No significant database matches. Doubtful CDS; hypothetical protein 437550..437651 Staphylococcus aureus subsp. aureus MRSA252 2860463 YP_039859.1 CDS SAR0402 NC_002952.2 438408 438569 R No significant database matches. Doubtful CDS; hypothetical protein complement(438408..438569) Staphylococcus aureus subsp. aureus MRSA252 2860464 YP_039860.1 CDS SAR0403 NC_002952.2 438584 439540 R hypothetical protein complement(438584..439540) Staphylococcus aureus subsp. aureus MRSA252 2861529 YP_039861.1 CDS SAR0404 NC_002952.2 439658 440320 R hypothetical protein complement(439658..440320) Staphylococcus aureus subsp. aureus MRSA252 2861530 YP_039862.1 CDS SAR0405 NC_002952.2 440463 440870 R hypothetical protein complement(440463..440870) Staphylococcus aureus subsp. aureus MRSA252 2861531 YP_039863.1 CDS xpt NC_002952.2 441383 441961 D Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 441383..441961 Staphylococcus aureus subsp. aureus MRSA252 2860432 YP_039864.1 CDS pbuX NC_002952.2 441961 443229 D Similar to Bacillus subtilis xanthine permease PbuX SW:PBUX_BACSU (P42086) (438 aa) fasta scores: E(): 4.8e-82, 56.532% id in 421 aa, and to Lactococcus lactis xanthine permease PbuX TR:Q9CGE9 (EMBL:AE006347) (434 aa) fasta scores: E(): 9.8e-71, 48.471% id in 425 aa; xanthine permease 441961..443229 Staphylococcus aureus subsp. aureus MRSA252 2861480 YP_039865.1 CDS guaB NC_002952.2 443267 444733 D Similar to Bacillus subtilis inosine-5'-monophosphate dehydrogenase GuaB SW:IMDH_BACSU (P21879) (513 aa) fasta scores: E(): 1.1e-130, 76.923% id in 481 aa, and to Bacillus halodurans inositol-monophosphate dehydrogenase GuaB TR:Q9KGN8 (EMBL:AP001507) (485 aa) fasta scores: E(): 8.1e-130, 74.029% id in 489 aa; inosine-5'-monophosphate dehydrogenase 443267..444733 Staphylococcus aureus subsp. aureus MRSA252 2859948 YP_039866.1 CDS guaA NC_002952.2 444758 446299 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 444758..446299 Staphylococcus aureus subsp. aureus MRSA252 2859947 YP_039867.1 CDS SAR0411 NC_002952.2 446829 447365 R hypothetical protein complement(446829..447365) Staphylococcus aureus subsp. aureus MRSA252 2861532 YP_039868.1 CDS SAR0414 NC_002952.2 448771 448947 R hypothetical protein complement(448771..448947) Staphylococcus aureus subsp. aureus MRSA252 2861534 YP_039869.1 CDS SAR0416 NC_002952.2 449607 >449954 R Internal region is similar to Escherichia coli sequence element IS911b transposase InsN SW:INN2_ECOLI (P39212) (100 aa) fasta scores: E(): 0.022, 29.885% id in 87 aa, and to Bacillus halodurans transposase TR:Q9JWP9 (EMBL:AP001518) (94 aa) fasta scores: E(): 1.4e-14, 54.839% id in 93 aa. CDS does not contain a conventional translational start codon; transposase complement(449607..>449954) Staphylococcus aureus subsp. aureus MRSA252 2861537 YP_039870.1 CDS SAR0418 NC_002952.2 450191 450352 R hypothetical protein complement(450191..450352) Staphylococcus aureus subsp. aureus MRSA252 2861538 YP_039871.1 CDS SAR0419 NC_002952.2 450752 450871 R hypothetical protein complement(450752..450871) Staphylococcus aureus subsp. aureus MRSA252 2861539 YP_039872.1 CDS SAR0420 NC_002952.2 450865 451224 R Similar to Lactococcus lactis hypothetical protein YtrP SW:YTRP_LACLA (Q02009) (119 aa) fasta scores: E(): 4e-19, 54.310% id in 116 aa, and to Neisseria meningitidis hypothetical protein NMB0528 TR:Q9K0Q6 (EMBL:AE002408) (123 aa) fasta scores: E(): 2.8e-08, 32.231% id in 121 aa; hypothetical protein complement(450865..451224) Staphylococcus aureus subsp. aureus MRSA252 2861540 YP_039873.1 CDS SAR0421 NC_002952.2 451243 452088 R Similar to Rhizobium loti hypothetical protein MLR1414 TR:BAB48794 (EMBL:AP002997) (297 aa) fasta scores: E(): 1e-15, 29.655% id in 290 aa, and to Escherichia coli hypothetical protein YtfG SW:YTFG_ECOLI (P39315) (286 aa) fasta scores: E(): 2e-15, 30.714% id in 280 aa; hypothetical protein complement(451243..452088) Staphylococcus aureus subsp. aureus MRSA252 2861541 YP_039874.1 CDS SAR0422 NC_002952.2 452560 453240 D these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 452560..453240 Staphylococcus aureus subsp. aureus MRSA252 2861542 YP_039875.1 CDS SAR0423 NC_002952.2 453523 454224 D these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 453523..454224 Staphylococcus aureus subsp. aureus MRSA252 2861543 YP_039876.1 CDS SAR0424 NC_002952.2 454512 455543 D these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 454512..455543 Staphylococcus aureus subsp. aureus MRSA252 2861544 YP_039877.1 CDS SAR0425 NC_002952.2 455890 456810 D these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 455890..456810 Staphylococcus aureus subsp. aureus MRSA252 2861545 YP_039878.1 CDS SAR0426 NC_002952.2 456957 457082 D hypothetical protein 456957..457082 Staphylococcus aureus subsp. aureus MRSA252 2861546 YP_039879.1 CDS set3 NC_002952.2 457171 457875 D SSL5, SET3, SET10; bind P-selectin glycoprotein ligand-1 and inhibit P-selectin-mediated neutrophil rolling along the endothelium; these proteins share structural homology to known superantigens but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 5 457171..457875 Staphylococcus aureus subsp. aureus MRSA252 2859140 YP_039880.1 CDS set1 NC_002952.2 458322 459017 D SSL7, SET1; blocks IgA-FcR interactions and inhibits complement, leading to increased survival of a sensitive bacterium in blood; superantigen-like protein 7 458322..459017 Staphylococcus aureus subsp. aureus MRSA252 2859139 YP_039881.1 CDS set5 NC_002952.2 459358 460056 D these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 459358..460056 Staphylococcus aureus subsp. aureus MRSA252 2859142 YP_039882.1 CDS set4 NC_002952.2 460419 461102 D these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 460419..461102 Staphylococcus aureus subsp. aureus MRSA252 2859141 YP_039883.1 CDS SAR0432 NC_002952.2 461180 461311 D hypothetical protein 461180..461311 Staphylococcus aureus subsp. aureus MRSA252 2861547 YP_039884.1 CDS SAR0433 NC_002952.2 461364 462920 D Similar to Escherichia coli type I restriction enzyme EcoR124II modification protein HsdM SW:T1M1_ECOLI (P10484) (520 aa) fasta scores: E(): 1.8e-74, 42.578% id in 512 aa, and to Streptococcus thermophilus type I modification subunit HsdM TR:Q9RNW1 (EMBL:AF177167) (531 aa) fasta scores: E(): 1.1e-85, 49.031% id in 516 aa. Similar to SAR1899, 98.456% identity (98.456% ungapped) in 518 aa overlap; type I restriction enzyme modification protein 461364..462920 Staphylococcus aureus subsp. aureus MRSA252 2861548 YP_039885.1 CDS SAR0434 NC_002952.2 462913 464145 D Similar to Lactococcus lactis type I restriction and modification system specificity subunit HsdS TR:Q9AJ85 (EMBL:AF142640) (410 aa) fasta scores: E(): 1.7e-20, 26.545% id in 437 aa, and to Streptococcus thermophilus restriction modification system specificity subunit HsdS TR:Q9RNW6 (EMBL:AF177166) (419 aa) fasta scores: E(): 2.6e-09, 24.775% id in 444 aa; restriction and modification system specificity protein 462913..464145 Staphylococcus aureus subsp. aureus MRSA252 2861549 YP_039886.1 CDS SAR0435 NC_002952.2 464528 465226 D these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein 464528..465226 Staphylococcus aureus subsp. aureus MRSA252 2861550 YP_039887.1 CDS SAR0436 NC_002952.2 465245 466732 D Poor database matches. Similar to Campylobacter jejuni hypothetical protein CJ0849c TR:Q9PP74 (EMBL:AL139076) (719 aa) fasta scores: E(): 0.28, 22.388% id in 402 aa, and to Saccharomyces cerevisiae intracellular protein transport protein Uso1 SW:USO1_YEAST (P25386) (1790 aa) fasta scores: E(): 2.2, 22.609% id in 460 aa; hypothetical protein 465245..466732 Staphylococcus aureus subsp. aureus MRSA252 2861551 YP_039888.1 CDS SAR0437 NC_002952.2 466838 467146 R hypothetical protein complement(466838..467146) Staphylococcus aureus subsp. aureus MRSA252 2861552 YP_039889.1 CDS SAR0438 NC_002952.2 467510 468295 D No significant database matches. Similar to SAR0439, 63.672% identity (63.922% ungapped) in 256 aa overlap, SAR0442, 63.118% identity (63.602% ungapped) in 263 aa overlap, SAR0443, 60.902% identity (62.548% ungapped) in 266 aa overlap, and SAR0444, 52.107% identity (52.918% ungapped) in 261 aa overlap; lipoprotein 467510..468295 Staphylococcus aureus subsp. aureus MRSA252 2861553 YP_039890.1 CDS SAR0439 NC_002952.2 468343 469116 D No significant database matches. Similar to SAR0442, 78.210% identity (78.516% ungapped) in 257 aa overlap, SAR0443, 77.692% identity (78.906% ungapped) in 260 aa overlap, and SAR0438, 63.672% identity (63.922% ungapped) in 256 aa overlap; lipoprotein 468343..469116 Staphylococcus aureus subsp. aureus MRSA252 2861554 YP_039891.1 CDS SAR0442 NC_002952.2 469987 470757 D No significant database matches. Similar to SAR0439, 78.210% identity (78.516% ungapped) in 257 aa overlap, SAR0443, 76.154% identity (77.647% ungapped) in 260 aa overlap, SAR0438, 63.118% identity (63.602% ungapped) in 263 aa overlap, and SAR0444, 56.757% identity (57.647% ungapped) in 259 aa overlap. Appears to have an uncleavable N-terminal signal sequence; hypothetical protein 469987..470757 Staphylococcus aureus subsp. aureus MRSA252 2861556 YP_039892.1 CDS SAR0443 NC_002952.2 470789 471589 D No significant database matches. Similar to SAR0439, 77.692% identity (78.906% ungapped) in 260 aa overlap, SAR0442, 76.154% identity (77.647% ungapped) in 260 aa overlap, and SAR0438, 60.902% identity (62.548% ungapped) in 266 aa overlap; lipoprotein 470789..471589 Staphylococcus aureus subsp. aureus MRSA252 2861557 YP_039893.1 CDS SAR0444 NC_002952.2 471608 472402 D No significant database matches. Similar to SAR2573, 64.314% identity (64.822% ungapped) in 255 aa overlap, SAR0106, 63.118% identity (65.613% ungapped) in 263 aa overlap, SAR2570, 61.923% identity (62.403% ungapped) in 260 aa overlap, SAR0445, 55.351% identity (57.034% ungapped) in 271 aa overlap, SAR0442, 56.757% identity (57.647% ungapped) in 259 aa overlap, SAR0438, 52.107% identity (52.918% ungapped) in 261 aa overlap, and SAR0443, 50.951% identity (52.344% ungapped) in 263 aa overlap; lipoprotein 471608..472402 Staphylococcus aureus subsp. aureus MRSA252 2861558 YP_039894.1 CDS SAR0445 NC_002952.2 472568 473389 D No significant database matches. Similar to SAR0444, 55.351% identity (57.034% ungapped) in 271 aa overlap, SAR2573, 50.373% identity (52.326% ungapped) in 268 aa overlap, and SAR0106, 50.000% identity (53.571% ungapped) in 270 aa overlap; lipoprotein 472568..473389 Staphylococcus aureus subsp. aureus MRSA252 2860895 YP_039895.1 CDS SAR0447 NC_002952.2 474706 475029 D hypothetical protein 474706..475029 Staphylococcus aureus subsp. aureus MRSA252 2860036 YP_039896.1 CDS SAR0448 NC_002952.2 475048 475362 D hypothetical protein 475048..475362 Staphylococcus aureus subsp. aureus MRSA252 2860037 YP_039897.1 CDS SAR0449 NC_002952.2 475651 475845 R hypothetical protein complement(475651..475845) Staphylococcus aureus subsp. aureus MRSA252 2860001 YP_039898.1 CDS SAR0450 NC_002952.2 476030 477232 D Similar to Pseudomonas chlororaphis hypothetical protein, needed for nitrile hydratase expression SW:P47K_PSECL (P31521) (419 aa) fasta scores: E(): 1.2e-55, 43.142% id in 401 aa, and to Bacillus subtilis hypothetical protein YciC TR:P94400 (EMBL:D50453) (397 aa) fasta scores: E(): 1.9e-100, 67.424% id in 396 aa; cobalamin synthesis protein 476030..477232 Staphylococcus aureus subsp. aureus MRSA252 2859555 YP_039899.1 CDS SAR0451 NC_002952.2 477501 477629 D hypothetical protein 477501..477629 Staphylococcus aureus subsp. aureus MRSA252 2859556 YP_039900.1 CDS SAR0452 NC_002952.2 478818 480302 D Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit 5 478818..480302 Staphylococcus aureus subsp. aureus MRSA252 2859557 YP_039901.1 CDS SAR0453 NC_002952.2 480315 483020 D Similar to Aquifex aeolicus hypothetical protein AG_863 TR:O67026 (EMBL:AE000711) (1007 aa) fasta scores: E(): 2.9e-42, 27.685% id in 1015 aa, and an internal region of Bacillus subtilis hypothetical protein YbcD TR:O87092 (EMBL:AB006424) (686 aa) fasta scores: E(): 7.8e-94, 46.501% id in 686 aa; hypothetical protein 480315..483020 Staphylococcus aureus subsp. aureus MRSA252 2859558 YP_039902.1 CDS SAR0454 NC_002952.2 483182 483544 D Similar to Bacillus subtilis hypothetical protein YbcI TR:O34380 (EMBL:Z99104) (124 aa) fasta scores: E(): 7.6e-32, 70.000% id in 120 aa, and to Bacillus halodurans hypothetical protein BH3870 TR:Q9K662 (EMBL:AP001520) (121 aa) fasta scores: E(): 3.8e-30, 66.387% id in 119 aa; hypothetical protein 483182..483544 Staphylococcus aureus subsp. aureus MRSA252 2859559 YP_039903.1 CDS SAR0455 NC_002952.2 483773 484120 R Poor database matches. C-terminal region is similar to Staphylococcus aureus hypothetical protein SAV0455 or SA0414 SWALL:Q99WE7 (EMBL:AP003359) (80 aa) fasta scores: E(): 1.7e-29, 98.75% id in 80 aa. Possible alternative translational start site; hypothetical protein complement(483773..484120) Staphylococcus aureus subsp. aureus MRSA252 2859560 YP_039904.1 CDS SAR0456 NC_002952.2 484227 484901 D Similar to Helicobacter pylori J99 hypothetical protein JHP0787 TR:Q9ZKZ5 (EMBL:AE001509) (228 aa) fasta scores: E(): 6.9e-13, 29.767% id in 215 aa, and to Bacillus megaterium hypothetical protein TR:Q06074 (EMBL:Z21972) (216 aa) fasta scores: E(): 2.1e-10, 26.244% id in 221 aa; hypothetical protein 484227..484901 Staphylococcus aureus subsp. aureus MRSA252 2859561 YP_039905.1 CDS SAR0457 NC_002952.2 484938 485672 D Similar to Bacillus stearothermophilus carboxylesterase precursor Est SW:EST_BACST (Q06174) (247 aa) fasta scores: E(): 1.3e-22, 31.020% id in 245 aa, and to Bacillus subtilis hypothetical protein YvaK TR:O32232 (EMBL:Z99121) (248 aa) fasta scores: E(): 2e-24, 31.837% id in 245 aa; hypothetical protein 484938..485672 Staphylococcus aureus subsp. aureus MRSA252 2859562 YP_039906.1 CDS SAR0457a NC_002952.2 485874 485963 D Doubtful CDS. No database matches; hypothetical protein 485874..485963 Staphylococcus aureus subsp. aureus MRSA252 2859563 YP_039907.1 CDS SAR0458 NC_002952.2 486126 487466 D Similar to Bacillus subtilis transporter YocR TR:O34383 (EMBL:AF027868) (445 aa) fasta scores: E(): 1.8e-73, 49.103% id in 446 aa, and to Bacillus halodurans sodium-dependent transporter BH0217 TR:Q9KG95 (EMBL:AP001507) (457 aa) fasta scores: E(): 1.1e-67, 46.727% id in 443 aa; sodium:neurotransmitter symporter family protein 486126..487466 Staphylococcus aureus subsp. aureus MRSA252 2859564 YP_039908.1 CDS SAR0459 NC_002952.2 487683 488588 D Similar to Bacillus subtilis cysteine synthase YrhA TR:O05393 (EMBL:U93874) (307 aa) fasta scores: E(): 2.4e-51, 51.864% id in 295 aa, and to Helicobacter pylori cysteine synthase HP0107 SW:CYSM_HELPY (P56067) (306 aa) fasta scores: E(): 4.7e-47, 48.993% id in 298 aa; pyridoxal-phosphate dependent protein 487683..488588 Staphylococcus aureus subsp. aureus MRSA252 2859565 YP_039909.1 CDS SAR0460 NC_002952.2 488581 489723 D Similar to Bacillus subtilis cystathionine gamma-lyase YrhB TR:O05394 (EMBL:U93874) (379 aa) fasta scores: E(): 7.2e-82, 57.632% id in 380 aa, and to Helicobacter pylori cystathionine gamma-synthase HP0106 SW:METB_HELPY (P56069) (380 aa) fasta scores: E(): 2.3e-76, 53.846% id in 377 aa; Cys/Met metabolism PLP-dependent enzyme 488581..489723 Staphylococcus aureus subsp. aureus MRSA252 2859566 YP_039910.1 CDS SAR0461 NC_002952.2 490014 491039 D Similar to Escherichia coli probable ATP-binding component of a transporter system Abc SW:ABC_ECOLI (P30750) (343 aa) fasta scores: E(): 1.7e-48, 46.313% id in 339 aa, and to Vibrio cholerae ABC transporter ATP-binding protein VC0907 TR:Q9KTJ5 (EMBL:AE004174) (344 aa) fasta scores: E(): 6.8e-49, 46.313% id in 339 aa; ABC transporter ATP-binding protein 490014..491039 Staphylococcus aureus subsp. aureus MRSA252 2859567 YP_039911.1 CDS SAR0462 NC_002952.2 491043 491702 D Similar to Salmonella enteritidis pathogenicity islet encoded integral membrane protein SfbC TR:Q9S4Y9 (EMBL:AF102556) (202 aa) fasta scores: E(): 2e-30, 48.969% id in 194 aa, and to Vibrio cholerae ABC transporter, permease VC0906 TR:Q9KTJ6 (EMBL:AE004174) (225 aa) fasta scores: E(): 5.7e-38, 51.659% id in 211 aa. CDS contains extra residues at the N-terminus in comparison to the S. enteritidis protein; transport system membrane protein 491043..491702 Staphylococcus aureus subsp. aureus MRSA252 2859568 YP_039912.1 CDS SAR0463 NC_002952.2 491739 492581 D Similar to Pasteurella haemolytica outer membrane lipoprotein 3 precursor PlpC SW:PLPC_PASHA (Q08870) (263 aa) fasta scores: E(): 1.8e-25, 38.846% id in 260 aa, and to Lactococcus lactis outer membrane lipoprotein precursor PlpB TR:Q9CIN7 (EMBL:AE006269) (286 aa) fasta scores: E(): 7.2e-31, 42.751% id in 269 aa; lipoprotein 491739..492581 Staphylococcus aureus subsp. aureus MRSA252 2859569 YP_039913.1 CDS SAR0464 NC_002952.2 492915 493919 D Similar to an internal region of Enterococcus faecalis autolysin precursor SW:ALYS_ENTFA (P37710) (671 aa) fasta scores: E(): 2.5e-18, 31.970% id in 269 aa, and to the C-terminal region of Bacillus subtilis endopeptidase precursor LytF TR:O07532 (EMBL:Y14079) (488 aa) fasta scores: E(): 1.4e-20, 34.591% id in 318 aa; hypothetical protein 492915..493919 Staphylococcus aureus subsp. aureus MRSA252 2859570 YP_039914.1 CDS SAR0465 NC_002952.2 494106 494375 R hypothetical protein complement(494106..494375) Staphylococcus aureus subsp. aureus MRSA252 2859571 YP_039915.1 CDS SAR0466 NC_002952.2 494516 494920 D Poor database matches. Similar to the N-terminal regions of Pseudomonas aeruginosa hypothetical protein PA3470 TR:Q9HYD6 (EMBL:AE004768) (152 aa) fasta scores: E(): 0.00013, 29.524% id in 105 aa, and to Streptococcus pneumoniae hypothetical protein TR:Q9K2H0 (EMBL:AF154045) (212 aa) fasta scores: E(): 0.0026, 30.275% id in 109 aa; MutT domain-containing protein 494516..494920 Staphylococcus aureus subsp. aureus MRSA252 2859572 YP_039916.1 CDS SAR0467 NC_002952.2 494910 495395 D Similar to Bacillus subtilis spermine/spermidine acetyltransferase BltD SW:BLTD_BACSU (P39909) (152 aa) fasta scores: E(): 0.0021, 21.154% id in 156 aa, and to Bacillus halodurans hypothetical protein BH3804 TR:Q9K6C5 (EMBL:AP001520) (167 aa) fasta scores: E(): 2.1e-10, 31.159% id in 138 aa. Possible alternative translational start site; acetyltransferase 494910..495395 Staphylococcus aureus subsp. aureus MRSA252 2859573 YP_039917.1 CDS SAR0468 NC_002952.2 495564 496346 R Similar to Lactococcus lactis hypothetical protein YibF TR:Q9CHC4 (EMBL:AE006314) (253 aa) fasta scores: E(): 4.4e-18, 26.172% id in 256 aa, and to an internal region of Streptomyces coelicolor membrane protein SCQ11.10c TR:Q9X9U1 (EMBL:AL096823) (513 aa) fasta scores: E(): 4.7e-14, 25.200% id in 250 aa; hypothetical protein complement(495564..496346) Staphylococcus aureus subsp. aureus MRSA252 2859574 YP_039918.1 CDS SAR0469 NC_002952.2 496343 497461 R Similar to Lactococcus lactis hypothetical protein YibE TR:Q9CHC5 (EMBL:AE006314) (393 aa) fasta scores: E(): 3.1e-24, 30.303% id in 363 aa, and to an internal region of Streptomyces coelicolor membrane protein SCQ11.10c TR:Q9X9U1 (EMBL:AL096823) (513 aa) fasta scores: E(): 8.5e-12, 26.102% id in 295 aa; hypothetical protein complement(496343..497461) Staphylococcus aureus subsp. aureus MRSA252 2859575 YP_039919.1 CDS SAR0470 NC_002952.2 497576 498460 R Similar to Bacillus subtilis glutamate biosynthesis transcriptional regulatory protein GltC SW:GLTC_BACSU (P20668) (300 aa) fasta scores: E(): 1.3e-14, 29.900% id in 301 aa. N-terminus is similar to the N-terminal region of Acinetobacter calcoaceticus cat operon transcriptional regulator CatM SW:CATM_ACICA (P07774) (303 aa) fasta scores: E(): 5.1e-12, 30.364% id in 247 aa; LysR family regulatory protein complement(497576..498460) Staphylococcus aureus subsp. aureus MRSA252 2859576 YP_039920.1 CDS gltA NC_002952.2 498641 503140 D Similar to Bacillus subtilis glutamate synthase [NADPH], large subunit protein GltB SW:GLTB_BACSU (P39812) (1520 aa) fasta scores: E(): 0, 53.329% id in 1517 aa, and to Campylobacter jejuni glutamate synthase GltB TR:Q9PJA4 (EMBL:AL139074) (1496 aa) fasta scores: E(): 0, 47.641% id in 1505 aa; glutamate synthase 498641..503140 Staphylococcus aureus subsp. aureus MRSA252 2859930 YP_039921.1 CDS gltD NC_002952.2 503158 504621 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase 503158..504621 Staphylococcus aureus subsp. aureus MRSA252 2859931 YP_039922.1 CDS SAR0473 NC_002952.2 505439 506866 D Similar to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SW:PTSB_STAXY (P51184) (480 aa) fasta scores: E(): 1.5e-74, 46.653% id in 478 aa, and to Bacillus halodurans PTS system, trehalose-specific enzyme IIBC component BH2216 TR:Q9KAS1 (EMBL:AP001514) (470 aa) fasta scores: E(): 8.2e-91, 54.873% id in 472 aa; sugar-specific PTS transport system, IIBC component 505439..506866 Staphylococcus aureus subsp. aureus MRSA252 2859577 YP_039923.1 CDS SAR0474 NC_002952.2 506930 508570 D Similar to Bacillus subtilis trehalose-6-phosphate hydrolase TreA SW:TREC_BACSU (P39795) (561 aa) fasta scores: E(): 1.8e-132, 59.538% id in 519 aa, and to Escherichia coli trehalose-6-phosphate hydrolase TreC SW:TREC_ECOLI (P28904) (551 aa) fasta scores: E(): 1.5e-119, 56.660% id in 503 aa; glycosyl hydrolase 506930..508570 Staphylococcus aureus subsp. aureus MRSA252 2859578 YP_039924.1 CDS SAR0475 NC_002952.2 508595 509323 D Similar to Bacillus subtilis trehalose operon transcriptional repressor TreR SW:TRER_BACSU (P39796) (238 aa) fasta scores: E(): 4e-26, 39.076% id in 238 aa, and to Bacillus halodurans trehalose operon transcriptional repressor TreR TR:Q9KEH9 (EMBL:AP001510) (237 aa) fasta scores: E(): 2e-26, 38.889% id in 234 aa; GntR family transcriptional regulator 508595..509323 Staphylococcus aureus subsp. aureus MRSA252 2859579 YP_039926.1 CDS SAR0476 NC_002952.2 509964 510488 D Similar to Lactococcus lactis hypothetical protein YafC TR:Q9CJE1 (EMBL:AE006244) (173 aa) fasta scores: E(): 9.5e-11, 28.902% id in 173 aa, and to Escherichia coli hypothetical protein YhbS SW:YHBS_ECOLI (P45473) (167 aa) fasta scores: E(): 4.1e-05, 27.972% id in 143 aa; acetyltransferase (GNAT) family protein 509964..510488 Staphylococcus aureus subsp. aureus MRSA252 2859581 YP_039927.1 CDS dnaX NC_002952.2 510557 512254 D N-terminus is similar to the N-terminal region of Escherichia coli DNA polymerase III, tau subunit protein DnaX SW:DP3X_ECOLI (P06710) (643 aa) fasta scores: E(): 8.3e-40, 36.404% id in 456 aa. Full length CDS is similar to Bacillus subtilis DNA polymerase III subunit gamma/tau DnaX SW:DP3X_BACSU (P09122) (563 aa) fasta scores: E(): 4e-80, 46.034% id in 580 aa; DNA polymerase III, tau subunit 510557..512254 Staphylococcus aureus subsp. aureus MRSA252 2859606 YP_039928.1 CDS SAR0478 NC_002952.2 512344 512661 D Similar to Bacillus subtilis hypothetical protein YaaK SW:YAAK_BACSU (P24281) (107 aa) fasta scores: E(): 1.9e-22, 66.981% id in 106 aa, and to Bacillus halodurans hypothetical protein BH0035 SW:Y035_BACHD (Q9JWQ5) (103 aa) fasta scores: E(): 1.2e-20, 64.000% id in 100 aa; hypothetical protein 512344..512661 Staphylococcus aureus subsp. aureus MRSA252 2859582 YP_039929.1 CDS recR NC_002952.2 512668 513264 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 512668..513264 Staphylococcus aureus subsp. aureus MRSA252 2859303 YP_039930.1 CDS SAR0480 NC_002952.2 519424 520212 R Similar to C-terminal region of Enterococcus faecium transposase TR:Q47815 (EMBL:L40841) (310 aa) fasta scores: E(): 1.9e-39, 46.183% id in 262 aa, and to the full length Neisseria gonorrhoeae hypothetical protein TR:Q50996 (EMBL:L36381) (267 aa) fasta scores: E(): 1.1e-27, 39.689% id in 257 aa; insertion element protein complement(519424..520212) Staphylococcus aureus subsp. aureus MRSA252 2859583 YP_039931.1 CDS SAR0481 NC_002952.2 520236 520991 R C-terminal is similar to Lactobacillus johnsonii insertion element IS1223 hypothetical protein SW:YI3A_LACJO (Q48585) (177 aa) fasta scores: E(): 2.7e-08, 33.140% id in 172 aa, and Lactococcus lactis hypothetical protein YgcE TR:O32786 (EMBL:X92946) (185 aa) fasta scores: E(): 7.2e-06, 26.404% id in 178 aa. Possible alternative translational start site; insertion element protein complement(520236..520991) Staphylococcus aureus subsp. aureus MRSA252 2859584 YP_039932.1 CDS SAR0482 NC_002952.2 521423 522760 D Similar to Bacillus subtilis hypothetical protein YaaO SW:YAAO_BACSU (P37536) (480 aa) fasta scores: E(): 3.4e-27, 35.908% id in 479 aa, and to Bacillus halodurans lysine decarboxylase BH0041 TR:Q9KGM0 (EMBL:AP001507) (482 aa) fasta scores: E(): 2.4e-21, 33.766% id in 462 aa; Orn/Lys/Arg decarboxylase 521423..522760 Staphylococcus aureus subsp. aureus MRSA252 2859585 YP_039933.1 CDS tmk NC_002952.2 522762 523379 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 522762..523379 Staphylococcus aureus subsp. aureus MRSA252 2859535 YP_039934.1 CDS SAR0484 NC_002952.2 523407 523736 D Similar to Bacillus halodurans hypothetical protein BH0043 TR:Q9KGL8 (EMBL:AP001507) (109 aa) fasta scores: E(): 8e-29, 66.055% id in 109 aa, and to Bacillus subtilis hypothetical protein YaaQ SW:YAAQ_BACSU (P37538) (109 aa) fasta scores: E(): 9.7e-28, 65.138% id in 109 aa; hypothetical protein 523407..523736 Staphylococcus aureus subsp. aureus MRSA252 2859586 YP_039935.1 CDS holB NC_002952.2 523950 524876 D Similar to Bacillus subtilis DNA polymerase III, delta' subunit protein HolB SW:HOLB_BACSU (P37540) (329 aa) fasta scores: E(): 3.3e-25, 31.699% id in 306 aa, and to Bacillus halodurans DNA polymerase III delta' subunit HolB TR:Q9KGL7 (EMBL:AP001507) (328 aa) fasta scores: E(): 9.1e-23, 30.421% id in 309 aa; DNA polymerase III subunit delta' 523950..524876 Staphylococcus aureus subsp. aureus MRSA252 2859644 YP_039936.1 CDS SAR0486 NC_002952.2 524877 525680 D Similar to Bacillus subtilis hypothetical protein YaaT SW:YAAT_BACSU (P37541) (275 aa) fasta scores: E(): 1.7e-62, 63.019% id in 265 aa, and to Bacillus halodurans signal peptidase-like protein BH0045 TR:Q9KGL6 (EMBL:AP001507) (275 aa) fasta scores: E(): 7.6e-60, 59.696% id in 263 aa; hypothetical protein 524877..525680 Staphylococcus aureus subsp. aureus MRSA252 2859587 YP_039937.1 CDS SAR0487 NC_002952.2 525697 526044 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 525697..526044 Staphylococcus aureus subsp. aureus MRSA252 2859456 YP_039938.1 CDS SAR0488 NC_002952.2 526318 527043 D Similar to Bacillus subtilis hypothetical protein YabB SW:YABB_BACSU (P37543) (247 aa) fasta scores: E(): 2.1e-42, 46.281% id in 242 aa, and to Streptococcus pyogenes hypothetical protein SPY1411 TR:Q99Z41 (EMBL:AE006578) (258 aa) fasta scores: E(): 4.2e-37, 41.803% id in 244 aa; hypothetical protein 526318..527043 Staphylococcus aureus subsp. aureus MRSA252 2859457 YP_039939.1 CDS SAR0489 NC_002952.2 527036 527284 D Similar to Halobacterium sp hypothetical protein VNG2274C TR:Q9HN31 (EMBL:AE005112) (77 aa) fasta scores: E(): 1.5e-13, 54.167% id in 72 aa, and to Bacillus subtilis hypothetical protein YazA TR:O31414 (EMBL:Z99104) (99 aa) fasta scores: E(): 4.3e-15, 53.086% id in 81 aa; hypothetical protein 527036..527284 Staphylococcus aureus subsp. aureus MRSA252 2859458 YP_039940.1 CDS SAR0490 NC_002952.2 527286 528125 D Similar to Bacillus halodurans BH0049 TR:Q9KGL2 (EMBL:AP001507) (289 aa) fasta scores: E(): 2.1e-45, 49.638% id in 276 aa, and to Bacillus subtilis hypothetical protein YabC SW:YABC_BACSU (P37544) (292 aa) fasta scores: E(): 3.3e-43, 46.595% id in 279 aa; tetrapyrrole (corrin/porphyrin) methylase 527286..528125 Staphylococcus aureus subsp. aureus MRSA252 2859459 YP_039941.1 CDS metG NC_002952.2 528410 530383 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 528410..530383 Staphylococcus aureus subsp. aureus MRSA252 2861163 YP_039942.1 CDS SAR0492 NC_002952.2 530414 531187 D Similar to Bacillus subtilis deoxyribonuclease YabD SW:YABD_BACSU (P37545) (255 aa) fasta scores: E(): 1.4e-65, 65.625% id in 256 aa, and to Vibrio cholerae hypothetical protein VC2014 TR:Q9KQI4 (EMBL:AE004276) (255 aa) fasta scores: E(): 4.8e-36, 42.802% id in 257 aa; TatD related DNase 530414..531187 Staphylococcus aureus subsp. aureus MRSA252 2859460 YP_039943.1 CDS SAR0493 NC_002952.2 531354 531890 D Similar to Bacillus subtilis hypothetical protein YabF SW:YABF_BACSU (P37547) (186 aa) fasta scores: E(): 2.8e-27, 52.809% id in 178 aa, and to Streptococcus pyogenes hypothetical protein SPY0261 TR:Q9A1I1 (EMBL:AE006492) (189 aa) fasta scores: E(): 1.5e-26, 48.619% id in 181 aa; hypothetical protein 531354..531890 Staphylococcus aureus subsp. aureus MRSA252 2859461 YP_039944.1 CDS ksgA NC_002952.2 531901 532794 D catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 531901..532794 Staphylococcus aureus subsp. aureus MRSA252 2859462 YP_039945.1 CDS veg NC_002952.2 532894 533157 D Similar to Bacillus subtilis hypothetical protein Veg SW:VEG_BACSU (P37466) (86 aa) fasta scores: E(): 2.3e-18, 62.025% id in 79 aa, and to Bacillus halodurans hypothetical protein BH0059 TR:Q9KGK2 (EMBL:AP001507) (88 aa) fasta scores: E(): 1.4e-17, 58.750% id in 80 aa; hypothetical protein 532894..533157 Staphylococcus aureus subsp. aureus MRSA252 2860427 YP_039946.1 CDS ipk NC_002952.2 533468 534316 D An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 533468..534316 Staphylococcus aureus subsp. aureus MRSA252 2859463 YP_039947.1 CDS purR NC_002952.2 534330 535154 D Similar to Bacillus subtilis pur operon repressor PurR SW:PURR_BACSU (P37551) (285 aa) fasta scores: E(): 1.5e-54, 54.212% id in 273 aa, and to Bacillus halodurans purine operon repressor PurR TR:Q9KGJ9 (EMBL:AP001507) (282 aa) fasta scores: E(): 1.4e-49, 49.814% id in 269 aa; pur operon repressor 534330..535154 Staphylococcus aureus subsp. aureus MRSA252 2859553 YP_039948.1 CDS yabJ NC_002952.2 535171 535551 D Similar to Bacillus subtilis regulator of purine biosynthesis YabJ SW:YABJ_BACSU (P37552) (124 aa) fasta scores: E(): 3.8e-25, 58.537% id in 123 aa, and to Bacillus halodurans translation initiation inhibitor BH0063 TR:Q9KGJ8 (EMBL:AP001507) (124 aa) fasta scores: E(): 2.1e-27, 62.097% id in 124 aa; regulatory protein 535171..535551 Staphylococcus aureus subsp. aureus MRSA252 2860434 YP_039949.1 CDS spoVG NC_002952.2 535624 535926 D stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus; regulatory protein SpoVG 535624..535926 Staphylococcus aureus subsp. aureus MRSA252 2859158 YP_039950.1 CDS glmU NC_002952.2 536269 537621 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 536269..537621 Staphylococcus aureus subsp. aureus MRSA252 2860694 YP_039951.1 CDS prs NC_002952.2 537768 538733 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 537768..538733 Staphylococcus aureus subsp. aureus MRSA252 2860154 YP_039952.1 CDS rplY NC_002952.2 538883 539536 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc 538883..539536 Staphylococcus aureus subsp. aureus MRSA252 2860920 YP_039953.1 CDS SAR0503 NC_002952.2 539847 540419 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 539847..540419 Staphylococcus aureus subsp. aureus MRSA252 2860453 YP_039954.1 CDS SAR0504 NC_002952.2 540419 543925 D Similar to Escherichia coli transcription-repair coupling factor Mfd SW:MFD_ECOLI (P30958) (1148 aa) fasta scores: E(): 2.1e-119, 37.169% id in 1095 aa, and to Bacillus subtilis transcription-repair coupling factor Mfd SW:MFD_BACSU (P37474) (1177 aa) fasta scores: E(): 1.2e-211, 49.490% id in 1176 aa; transcription-repair coupling factor 540419..543925 Staphylococcus aureus subsp. aureus MRSA252 2861065 YP_039955.1 CDS SAR0505 NC_002952.2 543915 545441 D Similar to Bacillus subtilis stage V sporulation protein B SpoVB SW:SP5B_BACSU (Q00758) (518 aa) fasta scores: E(): 4.8e-14, 23.819% id in 529 aa, and to Bacillus halodurans hypothetical protein BH0071 TR:Q9KGJ0 (EMBL:AP001507) (533 aa) fasta scores: E(): 3.2e-33, 30.906% id in 508 aa; polysaccharide biosynthesis protein 543915..545441 Staphylococcus aureus subsp. aureus MRSA252 2861066 YP_039956.1 CDS SAR0506 NC_002952.2 545441 546634 D N-terminus is similar to N-terminal regions of Bacillus halodurans hypothetical protein BH0072 TR:Q9KGI9 (EMBL:AP001507) (491 aa) fasta scores: E(): 3.8e-63, 49.435% id in 354 aa, and Bacillus subtilis hypothetical protein YabN SW:YABN_BACSU (P37556) (489 aa) fasta scores: E(): 2e-62, 50.282% id in 354 aa; tetrapyrrole (corrin/porphyrin) methylase 545441..546634 Staphylococcus aureus subsp. aureus MRSA252 2861067 YP_039957.1 CDS SAR0507 NC_002952.2 546631 546894 D Similar to Bacillus subtilis hypothetical protein YabO SW:YABO_BACSU (P37557) (86 aa) fasta scores: E(): 1.8e-18, 68.605% id in 86 aa, and to Bacillus halodurans hypothetical protein BH0073 TR:Q9KGI8 (EMBL:AP001507) (88 aa) fasta scores: E(): 5.9e-17, 67.901% id in 81 aa; S4 domain-containing protein 546631..546894 Staphylococcus aureus subsp. aureus MRSA252 2861068 YP_039958.1 CDS SAR0508 NC_002952.2 546912 547304 D Similar to Bacillus subtilis cell division protein DivIC SW:DIVC_BACSU (P37471) (125 aa) fasta scores: E(): 5.8e-06, 32.743% id in 113 aa, and to Listeria monocytogenes DivIC homolog DivL TR:Q9ZIM0 (EMBL:AF023181) (128 aa) fasta scores: E(): 2.5e-07, 37.097% id in 124 aa; cell division protein 546912..547304 Staphylococcus aureus subsp. aureus MRSA252 2861069 YP_039959.1 CDS SAR0509 NC_002952.2 547409 547810 D Similar to Bacillus subtilis hypothetical protein YabR SW:YABR_BACSU (P37560) (128 aa) fasta scores: E(): 3.4e-26, 63.433% id in 134 aa. N-terminal region is similar to the C-terminus of Escherichia coli polyribonucleotide nucleotidyltransferase Pnp SW:PNP_ECOLI (P05055) (711 aa) fasta scores: E(): 8.1e-08, 48.485% id in 99 aa; hypothetical protein 547409..547810 Staphylococcus aureus subsp. aureus MRSA252 2861070 YP_039960.1 CDS SAR0510 NC_002952.2 547990 549285 D Similar to Bacillus subtilis hypothetical protein YacA SW:YACA_BACSU (P37563) (472 aa) fasta scores: E(): 1e-15, 27.740% id in 447 aa, and to Buchnera aphidicola (subsp. Acyrthosiphon pisum) cell cycle protein BU110 SW:MESJ_BUCAI (P57211) (440 aa) fasta scores: E(): 2.5e-16, 25.120% id in 418 aa; hypothetical protein 547990..549285 Staphylococcus aureus subsp. aureus MRSA252 2861071 YP_039961.1 CDS hpt NC_002952.2 549290 549829 D Similar to Vibrio harveyi hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_VIBHA (P18134) (176 aa) fasta scores: E(): 4e-28, 50.000% id in 170 aa, and to Bacillus subtilis hypoxanthine-guanine phosphoribosyltransferase HprT SW:HPRT_BACSU (P37472) (180 aa) fasta scores: E(): 1.6e-37, 60.452% id in 177 aa; hypoxanthine phosphoribosyltransferase 549290..549829 Staphylococcus aureus subsp. aureus MRSA252 2859646 YP_039962.1 CDS ftsH NC_002952.2 550087 552180 D Similar to Bacillus firmus cell division protein FtsH homologue FtsH SW:FTSH_BACFI (P94304) (679 aa) fasta scores: E(): 8.4e-133, 61.437% id in 682 aa, and to Bacillus subtilis cell division protein FtsH homologue FtsH SW:FTSH_BACSU (P37476) (637 aa) fasta scores: E(): 4.1e-135, 66.984% id in 630 aa; cell division protein 550087..552180 Staphylococcus aureus subsp. aureus MRSA252 2860684 YP_039963.1 CDS hslO NC_002952.2 552594 553475 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 552594..553475 Staphylococcus aureus subsp. aureus MRSA252 2861072 YP_039964.1 CDS SAR0514 NC_002952.2 553654 554586 D Similar to Methanosarcina barkeri O-acetylserine CysK TR:Q9UWP0 (EMBL:AF174138) (308 aa) fasta scores: E(): 2.4e-61, 60.927% id in 302 aa, and to Bacillus subtilis cysteine synthase CysK SW:CYSK_BACSU (P37887) (307 aa) fasta scores: E(): 1.1e-76, 69.307% id in 303 aa; O-acetylserine (thiol)-lyase 553654..554586 Staphylococcus aureus subsp. aureus MRSA252 2861073 YP_039965.1 CDS folP NC_002952.2 554802 555605 D Previously sequenced as Staphylococcus aureus dihydropteroate synthase FolP SW:DHPS_STAAU (O05701) (267 aa) fasta scores: E(): 9.5e-100, 100.000% id in 267 aa. Similar to Staphylococcus haemolyticus dihydropteroate synthase FolP SW:DHPS_STAHA (Q59919) (267 aa) fasta scores: E(): 3.5e-76, 74.157% id in 267 aa; dihydropteroate synthase 554802..555605 Staphylococcus aureus subsp. aureus MRSA252 2860679 YP_039966.1 CDS folB NC_002952.2 555583 555948 D Previously sequenced as Staphylococcus aureus dihydroneopterin aldolase FolB SW:FOLB_STAAU (P56740) (121 aa) fasta scores: E(): 7.2e-44, 100.000% id in 121 aa. Similar to Bacillus subtilis dihydroneopterin aldolase FolB SW:FOLB_BACSU (P28823) (120 aa) fasta scores: E(): 1.8e-19, 47.863% id in 117 aa; dihydroneopterin aldolase 555583..555948 Staphylococcus aureus subsp. aureus MRSA252 2860675 YP_039967.1 CDS folK NC_002952.2 555945 556421 D Similar to Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK SW:HPPK_ECOLI (P26281) (158 aa) fasta scores: E(): 2e-18, 41.429% id in 140 aa, and to Bacillus subtilis 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK SW:HPPK_BACSU (P29252) (167 aa) fasta scores: E(): 9.9e-25, 53.030% id in 132 aa; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 555945..556421 Staphylococcus aureus subsp. aureus MRSA252 2860678 YP_039968.1 CDS lysS NC_002952.2 556960 558447 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 556960..558447 Staphylococcus aureus subsp. aureus MRSA252 2859815 YP_039969.1 CDS SAR0519 NC_002952.2 565186 565974 R Similar to C-terminal region of Enterococcus faecium transposase TR:Q47815 (EMBL:L40841) (310 aa) fasta scores: E(): 1.9e-39, 46.183% id in 262 aa, and to the full length Neisseria gonorrhoeae hypothetical protein TR:Q50996 (EMBL:L36381) (267 aa) fasta scores: E(): 1.1e-27, 39.689% id in 257 aa; insertion element protein complement(565186..565974) Staphylococcus aureus subsp. aureus MRSA252 2861074 YP_039970.1 CDS SAR0520 NC_002952.2 565998 566753 R C-terminal region is similar to Lactobacillus johnsonii insertion element IS1223 hypothetical protein SW:YI3A_LACJO (Q48585) (177 aa) fasta scores: E(): 2.9e-08, 33.526% id in 173 aa, and Lactococcus lactis hypothetical protein YgcE TR:O32786 (EMBL:X92946) (185 aa) fasta scores: E(): 4.8e-06, 26.404% id in 178 aa. Possible alternative translational start site; insertion element protein complement(565998..566753) Staphylococcus aureus subsp. aureus MRSA252 2861075 YP_039971.1 CDS SAR0521 NC_002952.2 567324 568706 R Similar to Rhizobium leguminosarum regulatory protein MocR TR:O85775 (EMBL:AF076240) (488 aa) fasta scores: E(): 2.7e-35, 30.297% id in 472 aa, and to Bacillus subtilis regulatory protein YdeL TR:P96669 (EMBL:AB001488) (463 aa) fasta scores: E(): 8.7e-54, 36.364% id in 451 aa; GntR family transcriptional regulator complement(567324..568706) Staphylococcus aureus subsp. aureus MRSA252 2861076 YP_039972.1 CDS SAR0522 NC_002952.2 568810 569697 D with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 568810..569697 Staphylococcus aureus subsp. aureus MRSA252 2861077 YP_039973.1 CDS SAR0523 NC_002952.2 569701 570261 D with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 569701..570261 Staphylococcus aureus subsp. aureus MRSA252 2861078 YP_039974.1 CDS nupC NC_002952.2 570468 571682 R Similar to Escherichia coli nucleoside permease NupC SW:NUPC_ECOLI (P33031) (400 aa) fasta scores: E(): 8.4e-72, 54.208% id in 404 aa, and to Bacillus subtilis pyrimidine nucleoside transport protein NupC SW:NUPC_BACSU (P39141) (393 aa) fasta scores: E(): 3.2e-59, 63.275% id in 403 aa; nucleoside permease complement(570468..571682) Staphylococcus aureus subsp. aureus MRSA252 2859170 YP_039975.1 CDS SAR0525 NC_002952.2 571840 572301 D Similar to Bacillus subtilis transcriptional regulator CtsR SW:CTSR_BACSU (P37568) (154 aa) fasta scores: E(): 4.6e-25, 50.685% id in 146 aa, and to Bacillus halodurans transcriptional regulator CtsR TR:Q9JWR8 (EMBL:AP001507) (156 aa) fasta scores: E(): 2.7e-24, 48.026% id in 152 aa; DNA-binding protein 571840..572301 Staphylococcus aureus subsp. aureus MRSA252 2861079 YP_039976.1 CDS SAR0526 NC_002952.2 572320 572886 D Similar to Bacillus halodurans hypothetical protein YacH TR:Q9JWP8 (EMBL:AP001507) (177 aa) fasta scores: E(): 1.5e-10, 32.203% id in 177 aa, and to Bacillus subtilis hypothetical protein YacH SW:YACH_BACSU (P37569) (185 aa) fasta scores: E(): 3.7e-11, 27.222% id in 180 aa; hypothetical protein 572320..572886 Staphylococcus aureus subsp. aureus MRSA252 2861080 YP_039977.1 CDS SAR0527 NC_002952.2 572876 573883 D N-terminus is similar to the C-terminal region of Penaeus japonicus arginine kinase SW:KARG_PENJP (P51545) (355 aa) fasta scores: E(): 1.5e-12, 26.66% id in 255 aa. Similar to Bacillus subtilis hypothetical ATP:guanido phosphotransferase YacI SW:YACI_BACSU (P37570) (363 aa) fasta scores: E(): 9.6e-48, 42.81% id in 341 aa; ATP:guanido phosphotransferase 572876..573883 Staphylococcus aureus subsp. aureus MRSA252 2861081 YP_039978.1 CDS clpC NC_002952.2 573897 576353 D Similar to Bacillus subtilis negative regulator of genetic competence ClpC SW:CLPC_BACSU (P37571) (810 aa) fasta scores: E(): 2.7e-189, 69.753% id in 810 aa, and to Bacillus halodurans class III stress response-related ATPase ClpC TR:Q9KGG2 (EMBL:AP001507) (813 aa) fasta scores: E(): 1.3e-189, 70.237% id in 803 aa; stress response-related Clp ATPase 573897..576353 Staphylococcus aureus subsp. aureus MRSA252 2859234 YP_039979.1 CDS radA NC_002952.2 576837 578201 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 576837..578201 Staphylococcus aureus subsp. aureus MRSA252 2859297 YP_039980.1 CDS SAR0530 NC_002952.2 578226 579299 D Similar to Bacillus halodurans hypothetical protein BH0106 TR:Q9KGF9 (EMBL:AP001507) (362 aa) fasta scores: E(): 5.3e-47, 39.718% id in 355 aa, and to Listeria monocytogenes hypothetical protein SW:YOR6_LISMO (Q48762) (357 aa) fasta scores: E(): 2.8e-42, 36.752% id in 351 aa; hypothetical protein 578226..579299 Staphylococcus aureus subsp. aureus MRSA252 2861082 YP_039981.1 CDS gltX NC_002952.2 579856 581310 D Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 579856..581310 Staphylococcus aureus subsp. aureus MRSA252 2859933 YP_039982.1 CDS cysE NC_002952.2 581734 582381 D Similar to Staphylococcus xylosus serine acetyltransferase CysE SW:CYSE_STAXY (P77985) (216 aa) fasta scores: E(): 1.1e-71, 87.324% id in 213 aa, and to Bacillus halodurans serine O-acetyltransferase CysE TR:Q9KGF5 (EMBL:AP001507) (229 aa) fasta scores: E(): 1.3e-49, 64.115% id in 209 aa. Possible alternative translational start site; serine acetyltransferase 581734..582381 Staphylococcus aureus subsp. aureus MRSA252 2859256 YP_039983.1 CDS cysS NC_002952.2 582365 583765 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 582365..583765 Staphylococcus aureus subsp. aureus MRSA252 2859258 YP_039984.1 CDS SAR0534 NC_002952.2 583758 584162 D Similar to Bacillus subtilis hypothetical protein YazC TR:O31418 (EMBL:Z99104) (143 aa) fasta scores: E(): 1.6e-21, 55.118% id in 127 aa, and to Streptococcus pyogenes hypothetical protein SPY1940 TR:Q99Y00 (EMBL:AE006617) (137 aa) fasta scores: E(): 6.5e-19, 44.444% id in 126 aa; hypothetical protein 583758..584162 Staphylococcus aureus subsp. aureus MRSA252 2861083 YP_039985.1 CDS yacO NC_002952.2 584170 584916 D Previously sequenced as Staphylococcus aureus rRNA methylase YacO TR:Q9AGT0 (EMBL:AF327733) (248 aa) fasta scores: E(): 6.7e-90, 99.194% id in 248 aa. Similar to Bacillus halodurans tRNA/rRNA methyltransferase BH0113 TR:Q9KGF2 (EMBL:AP001507) (249 aa) fasta scores: E(): 4.5e-51, 58.678% id in 242 aa; SpoU rRNA methylase 584170..584916 Staphylococcus aureus subsp. aureus MRSA252 2859627 YP_039986.1 CDS SAR0536 NC_002952.2 584916 585440 D Similar to Bacillus subtilis hypothetical protein YacP SW:YACP_BACSU (P37574) (170 aa) fasta scores: E(): 1.3e-19, 44.242% id in 165 aa, and to Bacillus halodurans hypothetical protein BH0114 TR:Q9KGF1 (EMBL:AP001507) (170 aa) fasta scores: E(): 1.5e-18, 42.941% id in 170 aa; hypothetical protein 584916..585440 Staphylococcus aureus subsp. aureus MRSA252 2861084 YP_039987.1 CDS sigH NC_002952.2 585521 586090 D Previously sequenced as Staphylococcus aureus hypothetical protein SigH TR:Q9AGS8 (EMBL:AF327733) (162 aa) fasta scores: E(): 4.1e-59, 98.148% id in 162 aa. Similar to Clostridium difficile hypothetical protein TcdD TR:Q9EXR1 (EMBL:AJ011301) (184 aa) fasta scores: E(): 0.027, 21.547% id in 181 aa; hypothetical protein 585521..586090 Staphylococcus aureus subsp. aureus MRSA252 2859144 YP_039988.1 CDS rpmG NC_002952.2 586205 586348 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 586205..586348 Staphylococcus aureus subsp. aureus MRSA252 2860164 YP_039989.1 CDS secE NC_002952.2 586404 586586 D forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 586404..586586 Staphylococcus aureus subsp. aureus MRSA252 2859134 YP_039990.1 CDS nusG NC_002952.2 586599 587147 D Similar to Escherichia coli transcription antitermination protein NusG SW:NUSG_ECOLI (P16921) (181 aa) fasta scores: E(): 7.9e-25, 40.884% id in 181 aa. Previously sequenced as Staphylococcus aureus transcription antitermination protein NusG SW:NUSG_STAAU (O08386) (182 aa) fasta scores: E(): 3.7e-67, 100.000% id in 182 aa; transcription antitermination protein 586599..587147 Staphylococcus aureus subsp. aureus MRSA252 2859172 YP_039991.1 CDS rplK NC_002952.2 587328 587750 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 587328..587750 Staphylococcus aureus subsp. aureus MRSA252 2860906 YP_039992.1 CDS rplA NC_002952.2 587958 588647 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 587958..588647 Staphylococcus aureus subsp. aureus MRSA252 2860898 YP_039993.1 CDS rplJ NC_002952.2 588922 589422 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 588922..589422 Staphylococcus aureus subsp. aureus MRSA252 2860905 YP_039994.1 CDS rplL NC_002952.2 589465 589833 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 589465..589833 Staphylococcus aureus subsp. aureus MRSA252 2860907 YP_039995.1 CDS SAR0546 NC_002952.2 590008 590616 D Similar to the C-terminal region of Escherichia coli ribosomal RNA small subunit methyltransferase C RsmC SW:RSMC_ECOLI (P39406) (342 aa) fasta scores: E(): 1.6e-09, 31.579% id in 171 aa. Full length CDS is similar to Bacillus subtilis hypothetical protein YbxB SW:YBXB_BACSU (P37872) (201 aa) fasta scores: E(): 2.7e-31, 49.500% id in 200 aa; hypothetical protein 590008..590616 Staphylococcus aureus subsp. aureus MRSA252 2861085 YP_039996.1 CDS rpoB NC_002952.2 590831 594382 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 590831..594382 Staphylococcus aureus subsp. aureus MRSA252 2860169 YP_039997.1 CDS rpoC NC_002952.2 594519 598142 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 594519..598142 Staphylococcus aureus subsp. aureus MRSA252 2860170 YP_039998.1 CDS SAR0549 NC_002952.2 598222 598533 D in Bacillus subtilis this non-essential protein associates with the ribosome; ribosomal protein L7Ae-like 598222..598533 Staphylococcus aureus subsp. aureus MRSA252 2861086 YP_039999.1 CDS rpsL NC_002952.2 598631 599044 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 598631..599044 Staphylococcus aureus subsp. aureus MRSA252 2861448 YP_040000.1 CDS rpsG NC_002952.2 599110 599580 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 599110..599580 Staphylococcus aureus subsp. aureus MRSA252 2860178 YP_040001.1 CDS fus NC_002952.2 599703 601784 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 599703..601784 Staphylococcus aureus subsp. aureus MRSA252 2860687 YP_040002.1 CDS tuf NC_002952.2 602001 603185 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 602001..603185 Staphylococcus aureus subsp. aureus MRSA252 2860408 YP_040003.1 CDS SAR0554 NC_002952.2 603466 604641 R Similar to Arabidopsis thaliana indole-3-acetic acid-amino acid hydrolase 3 precursor protein IAR3 SW:ILR3_ARATH (P54969) (438 aa) fasta scores: E(): 3.8e-46, 37.435% id in 382 aa, and to Bacillus halodurans N-acyl-L-amino acid amidohydrolase BH1613 TR:Q9KCF8 (EMBL:AP001512) (404 aa) fasta scores: E(): 2.6e-68, 48.518% id in 371 aa; peptidase complement(603466..604641) Staphylococcus aureus subsp. aureus MRSA252 2861087 YP_040004.1 CDS kbl NC_002952.2 604812 605999 D catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 604812..605999 Staphylococcus aureus subsp. aureus MRSA252 2859679 YP_040005.1 CDS SAR0556 NC_002952.2 606275 607153 D Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 606275..607153 Staphylococcus aureus subsp. aureus MRSA252 2861088 YP_040006.1 CDS SAR0557 NC_002952.2 607311 608948 D catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 607311..608948 Staphylococcus aureus subsp. aureus MRSA252 2861089 YP_040007.1 CDS SAR0558 NC_002952.2 609162 610127 D Similar to Staphylococcus carnosus hypothetical protein TR:Q9F331 (EMBL:AJ279090) (248 aa) fasta scores: E(): 4.6e-70, 74.486% id in 243 aa, and to Thermoplasma acidophilum UDP-glucose 4-epimerase related protein TA1111 TR:Q9HJ61 (EMBL:AL445066) (317 aa) fasta scores: E(): 1.3e-50, 48.077% id in 312 aa; hypothetical protein 609162..610127 Staphylococcus aureus subsp. aureus MRSA252 2860131 YP_040008.1 CDS SAR0559 NC_002952.2 610462 611538 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 610462..611538 Staphylococcus aureus subsp. aureus MRSA252 2860132 YP_040009.1 CDS SAR0560 NC_002952.2 611789 612472 D Similar to Escherichia coli phosphoglycolate phosphatase Gph SW:GPH_ECOLI (P32662) (252 aa) fasta scores: E(): 3.3e-05, 25.957% id in 235 aa, and to Staphylococcus carnosus hypothetical protein TR:Q9F327 (EMBL:AJ279090) (239 aa) fasta scores: E(): 4.2e-37, 50.216% id in 231 aa; haloacid dehalogenase-like hydrolase 611789..612472 Staphylococcus aureus subsp. aureus MRSA252 2860133 YP_040010.1 CDS SAR0561 NC_002952.2 612588 613250 R Similar to Lactobacillus acidophilus deoxyadenosine kinase subunit protein SW:DGK1_LACAC (Q59483) (214 aa) fasta scores: E(): 1e-17, 34.314% id in 204 aa, and to Bacillus subtilis hypothetical protein YaaF SW:YAAF_BACSU (P37529) (217 aa) fasta scores: E(): 7.8e-52, 64.151% id in 212 aa; deoxyadenosine kinase complement(612588..613250) Staphylococcus aureus subsp. aureus MRSA252 2860134 YP_040011.1 CDS SAR0562 NC_002952.2 613243 613860 R Similar to Lactobacillus acidophilus deoxyadenosine kinase subunit protein SW:DGK1_LACAC (Q59483) (214 aa) fasta scores: E(): 0.00015, 30.986% id in 213 aa, and to Bacillus subtilis hypothetical protein YaaG SW:YAAG_BACSU (P37530) (207 aa) fasta scores: E(): 1.6e-27, 48.990% id in 198 aa; deoxyadenosine kinase complement(613243..613860) Staphylococcus aureus subsp. aureus MRSA252 2860135 YP_040012.1 CDS SAR0563 NC_002952.2 613927 614397 D Similar to Bacillus subtilis hypothetical protein YaaJ SW:YAAJ_BACSU (P21335) (161 aa) fasta scores: E(): 1.2e-36, 61.039% id in 154 aa, and to Lactococcus lactis hypothetical protein YhcI TR:Q9CHK8 (EMBL:AE006305) (155 aa) fasta scores: E(): 4.5e-27, 50.694% id in 144 aa; deaminase 613927..614397 Staphylococcus aureus subsp. aureus MRSA252 2860136 YP_040013.1 CDS SAR0564 NC_002952.2 614544 615413 D Similar to Bacillus halodurans hypothetical protein BH1746 TR:Q9KC28 (EMBL:AP001513) (282 aa) fasta scores: E(): 1.9e-38, 45.423% id in 284 aa, and to Bacillus subtilis hypothetical protein YwtE TR:P96741 (EMBL:Z92954) (286 aa) fasta scores: E(): 1.9e-23, 34.146% id in 287 aa; haloacid dehalogenase-like hydrolase 614544..615413 Staphylococcus aureus subsp. aureus MRSA252 2860137 YP_040014.1 CDS SAR0565 NC_002952.2 615433 615999 D Similar to Bacillus sp OY1-2 azoreductase Azr TR:Q9FAW5 (EMBL:AB032601) (178 aa) fasta scores: E(): 1.4e-06, 32.778% id in 180 aa, and to Amycolatopsis mediterranei hypothtetical protein UrdO TR:CAC42480 (EMBL:AJ318385) (196 aa) fasta scores: E(): 3.1e-06, 29.379% id in 177 aa; hypothetical protein 615433..615999 Staphylococcus aureus subsp. aureus MRSA252 2860138 YP_040015.1 CDS sdrC NC_002952.2 616430 619150 D Similar to Staphylococcus aureus serine-aspartate repeat protein multigene family protein SdrC TR:O86487 (EMBL:AJ005645) (947 aa) fasta scores: E(): 7.4e-214, 87.751% id in 947 aa, and to Staphylococcus aureus bone sialoprotein-binding protein Bbp TR:Q9KWX6 (EMBL:Y18653) (1171 aa) fasta scores: E(): 3e-96, 47.355% id in 1172 aa. CDS contains dipetide repeat (SD x71) between residues 708 and 847. In comparison to the SdrC protein, the CDS contains extra copies of the SD repeat. Probable LPXTG-sorted surface protein; surface anchored protein 616430..619150 Staphylococcus aureus subsp. aureus MRSA252 2859132 YP_040016.1 CDS bbp NC_002952.2 619547 622960 D Similar to Staphylococcus aureus bone sialoprotein-binding protein Bbp TR:Q9KWX6 (EMBL:Y18653) (1171 aa) fasta scores: E(): 0, 95.559% id in 1171 aa, and to Staphylococcus aureus serine-aspartate repeat protein multigene family protein SdrE TR:O86489 (EMBL:AJ005647) (1166 aa) fasta scores: E(): 0, 84.991% id in 1166 aa. CDS contains dipetide repeat (SD x74) between residues 935 and 1078. In comparison to the Bpp protein, the CDS contains less copies of the SD repeat. Probable LPXTG-sorted surface protein; bone sialoprotein-binding protein 619547..622960 Staphylococcus aureus subsp. aureus MRSA252 2859885 YP_040017.1 CDS SAR0568 NC_002952.2 623079 624551 D Similar to Lactococcus lactis lipopolysaccharide biosynthesis protein YohJ TR:Q9CFL4 (EMBL:AE006375) (506 aa) fasta scores: E(): 1.4e-30, 26.969% id in 508 aa. Internal region of the CDS is similar to an internal region of Bacillus subtilis probable UDP-glucose:polyglycerol phosphate glucosyltransferase TagE SW:TAGE_BACSU (P13484) (673 aa) fasta scores: E(): 6.9e-23, 25.798% id in 376 aa; glycosyl transferase family protein 623079..624551 Staphylococcus aureus subsp. aureus MRSA252 2860139 YP_040018.1 CDS SAR0569 NC_002952.2 624677 626167 R Similar to Lactococcus lactis lipopolysaccharide biosynthesis protein YohJ TR:Q9CFL4 (EMBL:AE006375) (506 aa) fasta scores: E(): 2.3e-28, 26.600% id in 500 aa. Internal region of the CDS is similar to an internal region of Bacillus subtilis probable UDP-glucose:polyglycerol phosphate glucosyltransferase TagE SW:TAGE_BACSU (P13484) (673 aa) fasta scores: E(): 2e-22, 23.633% id in 512 aa; glycosyl transferase family protein complement(624677..626167) Staphylococcus aureus subsp. aureus MRSA252 2860140 YP_040019.1 CDS SAR0570 NC_002952.2 626449 627327 R similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis; GTP cyclohydrolase complement(626449..627327) Staphylococcus aureus subsp. aureus MRSA252 2860141 YP_040020.1 CDS SAR0571 NC_002952.2 627340 628005 R Similar to Bacillus halodurans hypothetical protein BH3320 TR:Q9K7P1 (EMBL:AP001518) (227 aa) fasta scores: E(): 3.5e-44, 54.709% id in 223 aa. C-terminal region is similar to Bacillus subtilis hypothetical protein YojG TR:O31857 (EMBL:Z99114) (142 aa) fasta scores: E(): 5.4e-18, 41.727% id in 139 aa; hypothetical protein complement(627340..628005) Staphylococcus aureus subsp. aureus MRSA252 2860142 YP_040021.1 CDS SAR0572 NC_002952.2 628019 628378 R Similar to Bacillus halodurans hypothetical protein BH3319 TR:Q9K7P2 (EMBL:AP001518) (115 aa) fasta scores: E(): 3.1e-23, 52.542% id in 118 aa, and to Bacillus subtilis hypothetical protein YojF TR:O31858 (EMBL:Z99114) (116 aa) fasta scores: E(): 1.7e-16, 39.496% id in 119 aa; hypothetical protein complement(628019..628378) Staphylococcus aureus subsp. aureus MRSA252 2860143 YP_040022.1 CDS SAR0573 NC_002952.2 628658 629416 D Similar to Giardia lamblia glucosamine-6-phosphate isomerase 1 GPI1 SW:GNP1_GIALA (O97439) (266 aa) fasta scores: E(): 5e-31, 44.076% id in 211 aa, and to Bacillus subtilis glucosamine-6-phosphate isomerase NagB SW:NAGB_BACSU (O35000) (242 aa) fasta scores: E(): 1.5e-35, 45.188% id in 239 aa; glucosamine-6-phosphate isomerase 628658..629416 Staphylococcus aureus subsp. aureus MRSA252 2860144 YP_040023.1 CDS SAR0574 NC_002952.2 629493 630125 D Similar to Methylomonas aminofaciens hexulose-6-phosphate synthase Hps SW:HUMS_METAM (Q48907) (208 aa) fasta scores: E(): 1.4e-21, 40.704% id in 199 aa, and to Bacillus subtilis probable hexulose-6-phosphate synthase YckG SW:HUMS_BACSU (P42405) (210 aa) fasta scores: E(): 6.8e-38, 56.039% id in 207 aa; hexulose-6-phosphate synthase 629493..630125 Staphylococcus aureus subsp. aureus MRSA252 2860019 YP_040024.1 CDS SAR0575 NC_002952.2 630127 630675 D Similar to Methylomonas aminofaciens 6-phospho-3-hexuloisomerase RmpB TR:Q9S0X3 (EMBL:AB026428) (181 aa) fasta scores: E(): 2.4e-16, 36.364% id in 187 aa, and to Bacillus subtilis hypothetical protein YckF SW:YCKF_BACSU (P42404) (185 aa) fasta scores: E(): 5.6e-21, 43.182% id in 176 aa; 6-phospho 3-hexuloisomerase 630127..630675 Staphylococcus aureus subsp. aureus MRSA252 2859822 YP_040025.1 CDS SAR0576 NC_002952.2 630788 631435 D Similar to Erwinia chrysanthemi probable indigoidine systhesis protein IdgB TR:Q9KHB5 (EMBL:AF265211) (230 aa) fasta scores: E(): 9.7e-14, 28.910% id in 211 aa, and to Bacillus halodurans phosphoglycolate phosphatase BH3587 TR:Q9K6Y7 (EMBL:AP001519) (215 aa) fasta scores: E(): 1.5e-11, 23.256% id in 215 aa; haloacid dehalogenase-like hydrolase 630788..631435 Staphylococcus aureus subsp. aureus MRSA252 2860020 YP_040026.1 CDS proP NC_002952.2 631938 633338 D Similar to Escherichia coli proline/betaine transporter ProP SW:PROP_ECOLI (P30848) (500 aa) fasta scores: E(): 2e-63, 38.158% id in 456 aa, and to Streptomyces coelicolor integral membrane transport protein SCC53.27 TR:Q9KXI4 (EMBL:AL357591) (462 aa) fasta scores: E(): 2.2e-72, 45.767% id in 437 aa; proline/betaine transporter 631938..633338 Staphylococcus aureus subsp. aureus MRSA252 2860152 YP_040027.1 CDS SAR0578 NC_002952.2 633590 633883 D No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 633590..633883 Staphylococcus aureus subsp. aureus MRSA252 2860021 YP_040028.1 CDS SAR0580 NC_002952.2 633883 635259 D Similar to Staphylococcus aureus menaquinone biosynthesis protein, O-succinylbenzoic acid--CoA ligase MenE SW:MENE_STAAU (Q53634) (492 aa) fasta scores: E(): 3.2e-16, 23.974% id in 463 aa. Previously sequenced as Staphylococcus aureus long chain fatty acid CoA ligase VraA TR:Q9KWK5 (EMBL:AB035449) (458 aa) fasta scores: E(): 1.1e-174, 97.817% id in 458 aa; AMP-binding protein 633883..635259 Staphylococcus aureus subsp. aureus MRSA252 2860996 YP_040029.1 CDS SAR0581 NC_002952.2 635261 636400 D Similar to Escherichia coli 3-ketoacyl-CoA thiolase FadA SW:THIK_ECOLI (P21151) (387 aa) fasta scores: E(): 1.4e-34, 34.091% id in 396 aa. Previously sequenced as Staphylococcus aureus acetyl-CoA c-acetyltransferase VraB TR:Q9KWK4 (EMBL:AB035449) (379 aa) fasta scores: E(): 8.9e-143, 98.681% id in 379 aa; ketoacyl-CoA thiolase 635261..636400 Staphylococcus aureus subsp. aureus MRSA252 2860997 YP_040030.1 CDS SAR0582 NC_002952.2 636375 636740 D Poor database matches. Similar to an internal region of Guillardia theta hypothetical protein chromosome 1 Orf183 TR:AAK39951 (EMBL:AF165818) (183 aa) fasta scores: E(): 2.5, 29.167% id in 120 aa; hypothetical protein 636375..636740 Staphylococcus aureus subsp. aureus MRSA252 2860998 YP_040031.1 CDS SAR0583 NC_002952.2 636743 637012 D Poor database matches. Similar to Lactococcus lactis hypothetical protein YseD TR:Q9CEQ1 (EMBL:AE006408) (97 aa) fasta scores: E(): 1.1, 27.586% id in 87 aa; hypothetical protein 636743..637012 Staphylococcus aureus subsp. aureus MRSA252 2860999 YP_040032.1 CDS SAR0584 NC_002952.2 637213 637380 R hypothetical protein complement(637213..637380) Staphylococcus aureus subsp. aureus MRSA252 2860022 YP_040033.1 CDS SAR0585 NC_002952.2 637913 638743 R Similar to Staphylococcus carnosus thiamin biosynthesis protein ThiD TR:Q9RGS7 (EMBL:AF109218) (273 aa) fasta scores: E(): 2.8e-28, 38.095% id in 273 aa, and to Bacillus subtilis phosphomethylpyrimidine kinase ThiD SW:THID_BACSU (P39610) (271 aa) fasta scores: E(): 1.8e-47, 51.136% id in 264 aa; phosphomethylpyrimidine kinase complement(637913..638743) Staphylococcus aureus subsp. aureus MRSA252 2860023 YP_040034.1 CDS ung NC_002952.2 638927 639583 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 638927..639583 Staphylococcus aureus subsp. aureus MRSA252 2860413 YP_040035.1 CDS SAR0587 NC_002952.2 639584 639964 D hypothetical protein 639584..639964 Staphylococcus aureus subsp. aureus MRSA252 2861007 YP_040036.1 CDS SAR0588 NC_002952.2 640097 640465 D Similar to Bacillus subtilis hypothetical protein YywK SW:YWDK_BACSU (P39619) (113 aa) fasta scores: E(): 3.4e-20, 60.577% id in 104 aa, and to Bacillus halodurans hypothetical protein BH3828 TR:Q9K6A1 (EMBL:AP001520) (121 aa) fasta scores: E(): 7.1e-17, 45.455% id in 121 aa; hypothetical protein 640097..640465 Staphylococcus aureus subsp. aureus MRSA252 2861008 YP_040037.1 CDS SAR0589 NC_002952.2 640586 642070 D C-terminal region is similar to Bacillus halodurans hypothetical protein BH0994 TR:Q9KE64 (EMBL:AP001510) (395 aa) fasta scores: E(): 8.9e-35, 31.156% id in 398 aa. Full length CDS is weakly similar to Streptomyces coelicolor amino acid transporter protein SCM10.26 TR:Q9RCX2 (EMBL:AL133469) (468 aa) fasta scores: E(): 5.6e-16, 26.509% id in 464 aa; amino acid permease 640586..642070 Staphylococcus aureus subsp. aureus MRSA252 2861009 YP_040038.1 CDS SAR0590 NC_002952.2 642212 642664 R Similar to Bacillus halodurans hypothetical protein BH0082 TR:Q9KGH9 (EMBL:AP001507) (150 aa) fasta scores: E(): 3.2e-10, 34.109% id in 129 aa, and to Pasteurella multocida hypothetical protein PM1894 TR:Q9CJU7 (EMBL:AE006227) (153 aa) fasta scores: E(): 0.00055, 25.000% id in 132 aa; hypothetical protein complement(642212..642664) Staphylococcus aureus subsp. aureus MRSA252 2860024 YP_040039.1 CDS SAR0591 NC_002952.2 642677 643441 R Similar to Streptococcus pneumoniae conserved hypothetical protein SP1731 TR:AAK75807 (EMBL:AE007466) (252 aa) fasta scores: E(): 1.9e-20, 35.547% id in 256 aa, and to Bacillus halodurans hypothetical protein BH0081 TR:Q9KGI0 (EMBL:AP001507) (251 aa) fasta scores: E(): 5.1e-20, 34.156% id in 243 aa; hypothetical protein complement(642677..643441) Staphylococcus aureus subsp. aureus MRSA252 2860025 YP_040040.1 CDS SAR0592 NC_002952.2 643752 643949 D No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 643752..643949 Staphylococcus aureus subsp. aureus MRSA252 2860026 YP_040041.1 CDS SAR0593 NC_002952.2 643989 644741 R Similar to Bacillus subtilis hypothetical protein YwfI SW:YWFI_BACSU (P39645) (254 aa) fasta scores: E(): 2e-67, 63.710% id in 248 aa, and to Bacillus halodurans hypothetical protein BH3825 TR:Q9K6A4 (EMBL:AP001520) (261 aa) fasta scores: E(): 2.6e-65, 59.036% id in 249 aa; heme peroxidase complement(643989..644741) Staphylococcus aureus subsp. aureus MRSA252 2860027 YP_040042.1 CDS eutD NC_002952.2 644909 645895 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 644909..645895 Staphylococcus aureus subsp. aureus MRSA252 2860155 YP_040043.1 CDS SAR0595 NC_002952.2 645898 646734 D Similar to Bacillus halodurans hypothetical protein BH3822 TR:Q9K6A7 (EMBL:AP001520) (278 aa) fasta scores: E(): 1.6e-53, 51.321% id in 265 aa, and to Bacillus subtilis hypothetical protein YwfL SW:YWFL_BACSU (P39648) (281 aa) fasta scores: E(): 2.4e-51, 53.358% id in 268 aa; lipoate-protein ligase A protein 645898..646734 Staphylococcus aureus subsp. aureus MRSA252 2860028 YP_040044.1 CDS mvaK1 NC_002952.2 647321 648241 D Previously sequenced as Staphylococcus aureus mevalonate kinase MvaK1 TR:Q9FD85 (EMBL:AF290087) (306 aa) fasta scores: E(): 7e-112, 99.346% id in 306 aa. Similar to Staphylococcus epidermidis mevalonate kinase MvaK1 TR:Q9FD74 (EMBL:AF290091) (306 aa) fasta scores: E(): 1e-88, 77.451% id in 306 aa; mevalonate kinase 647321..648241 Staphylococcus aureus subsp. aureus MRSA252 2861330 YP_040045.1 CDS mvaD NC_002952.2 648246 649229 D Previously sequenced as Staphylococcus aureus mevalonate diphosphate decarboxylase MvaD TR:Q9FD84 (EMBL:AF290087) (327 aa) fasta scores: E(): 4.3e-124, 99.388% id in 327 aa. Similar to Staphylococcus haemolyticus mevalonate diphosphate decarboxylase MvaD TR:Q9FD78 (EMBL:AF290089) (327 aa) fasta scores: E(): 5.1e-91, 73.538% id in 325 aa; mevalonate diphosphate decarboxylase 648246..649229 Staphylococcus aureus subsp. aureus MRSA252 2861329 YP_040046.1 CDS mvaK2 NC_002952.2 649242 650318 D Previously sequenced as Staphylococcus aureus phosphomevalonate kinase MvaK2 TR:Q9FD83 (EMBL:AF290087) (358 aa) fasta scores: E(): 4.2e-144, 99.721% id in 358 aa. Similar to Staphylococcus haemolyticus phosphomevalonate kinase MvaK2 TR:Q9FD77 (EMBL:AF290089) (358 aa) fasta scores: E(): 7.4e-118, 79.609% id in 358 aa; phosphomevalonate kinase 649242..650318 Staphylococcus aureus subsp. aureus MRSA252 2861331 YP_040047.1 CDS SAR0599 NC_002952.2 650495 650836 D No significant database matches to the full length CDS. N-terminal region is similar to Bacillus subtilis hypothetical protein YwzC TR:O32280 (EMBL:Z99123) (74 aa) fasta scores: E(): 1.6e-13, 63.514% id in 74 aa, and to Bacillus halodurans hypothetical protein BH3821 TR:Q9K6A8 (EMBL:AP001520) (74 aa) fasta scores: E(): 6.5e-13, 67.568% id in 74 aa. CDS contains N-terminal hydrophilic region; hypothetical protein 650495..650836 Staphylococcus aureus subsp. aureus MRSA252 2860029 YP_040048.1 CDS SAR0600 NC_002952.2 650888 652210 R Similar to Burkholderia cepacia glutathione reductase Gor SW:GSHR_BURCE (P48639) (449 aa) fasta scores: E(): 6.1e-35, 30.853% id in 457 aa, and to Escherichia coli probable pyridine nucleotide-disulfide oxidoreductase YkgC SW:YKGC_ECOLI (P77212) (450 aa) fasta scores: E(): 1.1e-79, 49.433% id in 441 aa; pyridine nucleotide-disulfide oxidoreductase complement(650888..652210) Staphylococcus aureus subsp. aureus MRSA252 2860030 YP_040049.1 CDS SAR0601 NC_002952.2 652197 652637 R Poor database matches. Weak similarity to Bacillus halodurans hypothetical protein BH0656 TR:Q9Z9W2 (EMBL:AB011836) (132 aa) fasta scores: E(): 0.042, 25.373% id in 134 aa, and Pseudomonas aeruginosa probable transcriptional regulator PA2692 TR:Q9I0F0 (EMBL:AE004697) (174 aa) fasta scores: E(): 9.8, 25.714% id in 140 aa; hypothetical protein complement(652197..652637) Staphylococcus aureus subsp. aureus MRSA252 2860236 YP_040050.1 CDS SAR0602 NC_002952.2 653261 654655 D N-terminal region is similar to Staphylococcus haemolyticus hypothetical protein TR:Q9F2H7 (EMBL:AJ302698) (373 aa) fasta scores: E(): 4.1e-43, 46.076% id in 395 aa. Full length CDS is similar to Bacillus halodurans transposase BH0978 TR:Q9KE78 (EMBL:AP001510) (503 aa) fasta scores: E(): 9e-14, 24.540% id in 489 aa; hypothetical protein 653261..654655 Staphylococcus aureus subsp. aureus MRSA252 2860237 YP_040051.1 CDS SAR0603 NC_002952.2 654659 655294 D Poor database matches. Similar to Staphylococcus haemolyticus hypothetical protein TR:Q9F2H5 (EMBL:AJ302698) (220 aa) fasta scores: E(): 3.5e-06, 24.645% id in 211 aa. Similar to SAR0607, 52.451% identity (52.709% ungapped) in 204 aa overlap; hypothetical protein 654659..655294 Staphylococcus aureus subsp. aureus MRSA252 2860238 YP_040052.1 CDS SAR0604 NC_002952.2 655260 655529 D No significant database matches. Doubtful CDS, poor translational start site. Similar to the C-terminal region of SAR0602, 65.789% identity (69.444% ungapped) in 76 aa overlap; hypothetical protein 655260..655529 Staphylococcus aureus subsp. aureus MRSA252 2860239 YP_040053.1 CDS SAR0607 NC_002952.2 656291 656920 D Similar to Staphylococcus haemolyticus hypothetical protein TR:Q9F2H5 (EMBL:AJ302698) (220 aa) fasta scores: E(): 8.6e-06, 25.000% id in 192 aa. Similar to SAR0603, 52.451% identity (52.709% ungapped) in 204 aa overlap, and to the N-terminal region of SAR0605, 66.667% identity (66.667% ungapped) in 66 aa overlap; hypothetical protein 656291..656920 Staphylococcus aureus subsp. aureus MRSA252 2860241 YP_040054.1 CDS SAR0608 NC_002952.2 657373 658311 D Similar to Bacillus subtilis possible inositol catabolism protein IolS SW:IOLS_BACSU (P46336) (310 aa) fasta scores: E(): 3.1e-65, 60.450% id in 311 aa, and to Thermotoga maritima aldo/keto reductase oxidoreductase TM1006 TR:Q9X0A1 (EMBL:AE001762) (333 aa) fasta scores: E(): 1.3e-25, 35.783% id in 313 aa; aldo/keto reductase 657373..658311 Staphylococcus aureus subsp. aureus MRSA252 2860242 YP_040055.1 CDS SAR0609 NC_002952.2 658521 659057 D Similar to Bacillus subtilis hypothetical protein YwqN TR:P96726 (EMBL:Z92952) (181 aa) fasta scores: E(): 5.9e-27, 42.353% id in 170 aa, and to Streptomyces coelicolor hypothetical protein SCD20.05c TR:Q9F2X4 (EMBL:AL392148) (200 aa) fasta scores: E(): 2.8e-16, 33.140% id in 172 aa; hypothetical protein 658521..659057 Staphylococcus aureus subsp. aureus MRSA252 2860243 YP_040056.1 CDS SAR0610 NC_002952.2 659226 659702 D Similar to Sus scrofa (Pig) diamine acetyltransferase Sat SW:ATDA_PIG (Q28999) (171 aa) fasta scores: E(): 0.01, 28.477% id in 151 aa, and to Rhizobium loti hypothetical protein MLR0192 TR:BAB47829 (EMBL:AP002994) (163 aa) fasta scores: E(): 1.3e-09, 37.419% id in 155 aa; acetyltransferase 659226..659702 Staphylococcus aureus subsp. aureus MRSA252 2860244 YP_040057.1 CDS SAR0611 NC_002952.2 659742 661037 D Similar to Bacillus subtilis hypothetical protein YwfO SW:YWFO_BACSU (P39651) (433 aa) fasta scores: E(): 4.1e-108, 64.320% id in 412 aa, and to Bacillus halodurans hypothetical protein BH3818 TR:Q9K6B1 (EMBL:AP001520) (432 aa) fasta scores: E(): 1.8e-101, 59.028% id in 432 aa; phosphohydrolase 659742..661037 Staphylococcus aureus subsp. aureus MRSA252 2860245 YP_040058.1 CDS SAR0612 NC_002952.2 661080 661586 D Similar to Bacillus subtilis hypothetical protein YwhD TR:P70996 (EMBL:Z80360) (172 aa) fasta scores: E(): 9e-40, 57.576% id in 165 aa, and to Bacillus halodurans hypothetical protein BH3813 TR:Q9K6B6 (EMBL:AP001520) (179 aa) fasta scores: E(): 7.2e-30, 46.626% id in 163 aa; hypothetical protein 661080..661586 Staphylococcus aureus subsp. aureus MRSA252 2860246 YP_040059.1 CDS adhA NC_002952.2 662085 663095 D similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 662085..663095 Staphylococcus aureus subsp. aureus MRSA252 2859061 YP_040060.1 CDS SAR0614 NC_002952.2 663359 663787 D Similar to Bacillus subtilis hypothetical protein YwiB TR:O07624 (EMBL:Z97024) (142 aa) fasta scores: E(): 3.9e-07, 26.471% id in 136 aa, and to Bacillus halodurans hypothetical protein BH3809 TR:Q9K6C0 (EMBL:AP001520) (144 aa) fasta scores: E(): 0.0088, 24.088% id in 137 aa; hypothetical protein 663359..663787 Staphylococcus aureus subsp. aureus MRSA252 2860247 YP_040061.1 CDS argS NC_002952.2 663784 665445 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 663784..665445 Staphylococcus aureus subsp. aureus MRSA252 2859857 YP_040062.1 CDS SAR0617 NC_002952.2 665852 666487 D Similar to Methanococcus jannaschii hypothetical protein MJ1434 TR:Q58829 (EMBL:U67584) (220 aa) fasta scores: E(): 4.4e-23, 37.198% id in 207 aa, and to Thermotoga maritima repair endonuclease TM0382 TR:Q9WYL3 (EMBL:AE001718) (232 aa) fasta scores: E(): 4.8e-17, 35.417% id in 192 aa; DNA repair protein 665852..666487 Staphylococcus aureus subsp. aureus MRSA252 2860248 YP_040063.1 CDS SAR0618 NC_002952.2 666806 667693 D Similar to Salmonella typhimurium cobalamin transport periplasmic binding protein BtuF TR:Q9ZFP9 (EMBL:AF096877) (266 aa) fasta scores: E(): 2.8e-09, 26.482% id in 253 aa, and to Bacillus subtilis metal binding protein YvrC TR:O34805 (EMBL:Z99120) (314 aa) fasta scores: E(): 2.2e-33, 41.667% id in 312 aa; transport system lipoprotein 666806..667693 Staphylococcus aureus subsp. aureus MRSA252 2860249 YP_040064.1 CDS SAR0619 NC_002952.2 667843 668793 D Similar to Bacillus subtilis hemin permease YvrB TR:O34451 (EMBL:Z99120) (353 aa) fasta scores: E(): 2.1e-23, 32.143% id in 308 aa, and to Pyrococcus abyssi iron (III) ABC transporter, permease PAB1535 TR:Q9UZ79 (EMBL:AJ248287) (331 aa) fasta scores: E(): 2.7e-21, 30.744% id in 309 aa; FecCD transport family protein 667843..668793 Staphylococcus aureus subsp. aureus MRSA252 2860250 YP_040065.1 CDS SAR0620 NC_002952.2 668848 669567 D Similar to Burkholderia cepacia 2-haloalkanoic acid dehalogenase IVa Hdl IVa SW:HAD4_BURCE (Q51645) (230 aa) fasta scores: E(): 5e-06, 24.771% id in 218 aa, and to Pyrococcus horikoshii hypothetical protein PH0459 TR:O58216 (EMBL:AP000002) (232 aa) fasta scores: E(): 3e-11, 27.706% id in 231 aa; haloacid dehalogenase-like hydrolase 668848..669567 Staphylococcus aureus subsp. aureus MRSA252 2860251 YP_040066.1 CDS SAR0621 NC_002952.2 669551 670351 D Similar to Pseudomonas sp esterase V Est5 TR:Q9Z3U8 (EMBL:D14529) (262 aa) fasta scores: E(): 3e-08, 23.755% id in 261 aa, and to Archaeoglobus fulgidus putataive 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase AF1706 TR:O28567 (EMBL:AE000986) (238 aa) fasta scores: E(): 3.8e-13, 28.139% id in 231 aa; hydrolase 669551..670351 Staphylococcus aureus subsp. aureus MRSA252 2860252 YP_040067.1 CDS SAR0622 NC_002952.2 670487 670993 D No significant database matches to the full length CDS. N-terminus is weakly similar to the N-terminal region of Clostridium acetobutylicum regulatory protein TR:Q45805 (EMBL:U15277) (148 aa) fasta scores: E(): 9.7, 22.018% id in 109 aa; hypothetical protein 670487..670993 Staphylococcus aureus subsp. aureus MRSA252 2860253 YP_040068.1 CDS SAR0623 NC_002952.2 671155 671871 D No significant database matches to the full length CDS. C-terminus is weakly similar to the N-terminal region of Phytophthora infestans mitochondrial SecY-independent transporter protein Ymf16 TR:Q9T238 (EMBL:U17009) (248 aa) fasta scores: E(): 0.78, 25.806% id in 186 aa; hypothetical protein 671155..671871 Staphylococcus aureus subsp. aureus MRSA252 2860254 YP_040069.1 CDS SAR0624 NC_002952.2 672040 672828 D Similar to Pseudomonas sp esterase V Est5 TR:Q9Z3U8 (EMBL:D14529) (262 aa) fasta scores: E(): 1.1e-08, 24.904% id in 261 aa, and to Vibrio cholerae esterase/lipase YbfF TR:Q9KQA3 (EMBL:AE004283) (257 aa) fasta scores: E(): 8.7e-12, 24.615% id in 260 aa; esterase 672040..672828 Staphylococcus aureus subsp. aureus MRSA252 2860255 YP_040070.1 CDS sarA NC_002952.2 673078 673452 R Previously sequenced as Staphylococcus aureus agr regulon and exoprotein expression regulator, staphylococcal accessory regulator A, SarA TR:Q53777 (EMBL:U46541) (113 aa) fasta scores: E(): 4.5e-36, 99.115% id in 113 aa. Similar to Staphylococcus epidermidis staphylococcal accessory regulator A homologue SarA TR:O85233 (EMBL:AF054173) (124 aa) fasta scores: E(): 9e-35, 85.484% id in 124 aa; accessory regulator A complement(673078..673452) Staphylococcus aureus subsp. aureus MRSA252 2861466 YP_040071.1 CDS SAR0626 NC_002952.2 674399 675328 R Similar to Lactococcus lactis hypothetical protein YsbC TR:Q9CES9 (EMBL:AE006405) (307 aa) fasta scores: E(): 2.6e-26, 33.974% id in 312 aa. N-terminal region is similar to Pasteurella multocida hypothetical protein PM1890 TR:Q9CJV1 (EMBL:AE006226) (156 aa) fasta scores: E(): 9.6e-09, 33.333% id in 147 aa; hypothetical protein complement(674399..675328) Staphylococcus aureus subsp. aureus MRSA252 2860256 YP_040072.1 CDS SAR0627 NC_002952.2 675521 675745 R hypothetical protein complement(675521..675745) Staphylococcus aureus subsp. aureus MRSA252 2860257 YP_040073.1 CDS SAR0628 NC_002952.2 675762 675965 R hypothetical protein complement(675762..675965) Staphylococcus aureus subsp. aureus MRSA252 2860258 YP_040074.1 CDS SAR0629 NC_002952.2 676120 676680 D Similar to Escherichia coli type 1 fimbriae regulatory protein FimE SW:FIME_ECOLI (P04741) (198 aa) fasta scores: E(): 2.3e-06, 30.488% id in 164 aa, and to Bacillus halodurans hypothetical protein BH4039 TR:Q9K5P9 (EMBL:AP001520) (182 aa) fasta scores: E(): 3.7e-14, 32.934% id in 167 aa; phage integrase 676120..676680 Staphylococcus aureus subsp. aureus MRSA252 2860259 YP_040075.1 CDS SAR0630 NC_002952.2 676699 679101 D subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit A 676699..679101 Staphylococcus aureus subsp. aureus MRSA252 2860260 YP_040076.1 CDS SAR0631 NC_002952.2 679088 679513 D subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit B 679088..679513 Staphylococcus aureus subsp. aureus MRSA252 2860261 YP_040077.1 CDS SAR0632 NC_002952.2 679510 679854 D subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit C 679510..679854 Staphylococcus aureus subsp. aureus MRSA252 2860262 YP_040078.1 CDS SAR0633 NC_002952.2 679844 681340 D subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; in S. meliloti it is known to be involved specifically with K+ transport; monovalent cation/H+ antiporter subunit D 679844..681340 Staphylococcus aureus subsp. aureus MRSA252 2860263 YP_040079.1 CDS SAR0634 NC_002952.2 681341 681823 D subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport; monovalent cation/H+ antiporter subunit E 681341..681823 Staphylococcus aureus subsp. aureus MRSA252 2860264 YP_040080.1 CDS SAR0635 NC_002952.2 681820 682122 D subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit F 681820..682122 Staphylococcus aureus subsp. aureus MRSA252 2860265 YP_040081.1 CDS SAR0637 NC_002952.2 682874 684916 D Similar to Bacillus subtilis hypothetical protein YvgP TR:O32212 (EMBL:Z99121) (670 aa) fasta scores: E(): 1.5e-47, 32.562% id in 691 aa, and to Bifidobacterium longum Na+/H+ antiporter protein NhaB TR:Q9F9W8 (EMBL:AF160969) (690 aa) fasta scores: E(): 2.2e-35, 30.183% id in 709 aa; sodium/hydrogen exchanger family protein 682874..684916 Staphylococcus aureus subsp. aureus MRSA252 2860267 YP_040082.1 CDS SAR0638 NC_002952.2 685002 686150 R Similar to Bacillus subtilis hypothetical protein YbcL TR:O34663 (EMBL:Z99104) (390 aa) fasta scores: E(): 2.3e-23, 25.594% id in 379 aa, and to Pseudomonas aeruginosa probable MFS transporter PA3303 TR:Q9HYU1 (EMBL:AE004752) (391 aa) fasta scores: E(): 9.2e-21, 25.956% id in 366 aa; hypothetical protein complement(685002..686150) Staphylococcus aureus subsp. aureus MRSA252 2860268 YP_040083.1 CDS SAR0641 NC_002952.2 687790 688719 R Similar to Staphylococcus epidermidis iron repressible ABC transport system lipoprotein TR:P72415 (EMBL:X99127) (309 aa) fasta scores: E(): 3e-85, 77.023% id in 309 aa, and to Streptococcus pneumoniae surface adhesin A precursor PsaA TR:P72538 (EMBL:U53509) (309 aa) fasta scores: E(): 4.4e-52, 50.489% id in 307 aa; ABC transporter complement(687790..688719) Staphylococcus aureus subsp. aureus MRSA252 2860270 YP_040084.1 CDS SAR0642 NC_002952.2 688716 689552 R Similar to Yersinia pestis chelated iron transport system membrane protein YfeD SW:YFED_YERPE (Q56955) (297 aa) fasta scores: E(): 7.8e-33, 36.496% id in 274 aa, and to Staphylococcus epidermidis iron repressible ABC transport system membrane protein TR:P72414 (EMBL:X99127) (248 aa) fasta scores: E(): 1.4e-64, 83.468% id in 248 aa; ABC transporter permease complement(688716..689552) Staphylococcus aureus subsp. aureus MRSA252 2861619 YP_040085.1 CDS SAR0643 NC_002952.2 689546 690289 R Similar to Treponema pallidum zinc transport system ATP-binding protein TroB SW:TROB_TREPA (P96117) (266 aa) fasta scores: E(): 1e-25, 41.346% id in 208 aa, and to Staphylococcus epidermidis iron repressible ABC transport system ATP binding protein TR:P72413 (EMBL:X99127) (248 aa) fasta scores: E(): 1.2e-51, 67.089% id in 237 aa; ABC transporter ATP-binding protein complement(689546..690289) Staphylococcus aureus subsp. aureus MRSA252 2861620 YP_040086.1 CDS sirR NC_002952.2 690411 691055 D Similar to Streptococcus gordonii metalloregulator RmtA TR:Q9RFN3 (EMBL:AF182402) (215 aa) fasta scores: E(): 2.6e-24, 37.209% id in 215 aa, and to Staphylococcus epidermidis iron dependant repressor SirR TR:P72424 (EMBL:X99128) (214 aa) fasta scores: E(): 8.5e-66, 82.243% id in 214 aa; metalloregulator 690411..691055 Staphylococcus aureus subsp. aureus MRSA252 2859148 YP_040087.1 CDS SAR0645 NC_002952.2 691135 691887 R Poor database matches. Similar to an internal region of Saccharomyces cerevisiae chromosome XII hypothetical protein YLL031c TR:Q07830 (EMBL:Z73136) (1017 aa) fasta scores: E(): 0.98, 21.992% id in 241 aa; hypothetical protein complement(691135..691887) Staphylococcus aureus subsp. aureus MRSA252 2861621 YP_040088.1 CDS tagA NC_002952.2 692123 692887 D Similar to Bacillus subtilis teichoic acid biosynthesis protein A TagA SW:TAGA_BACSU (P27620) (256 aa) fasta scores: E(): 1.6e-23, 32.083% id in 240 aa, and to Thermoanaerobacter thermohydrosulfuricus (Clostridium thermohydrosulfuricum) hypothetical protein Lta1 TR:Q9JRP3 (EMBL:AJ401026) (245 aa) fasta scores: E(): 6.6e-31, 37.603% id in 242 aa; teichoic acid biosynthesis protein 692123..692887 Staphylococcus aureus subsp. aureus MRSA252 2859514 YP_040089.1 CDS tagH NC_002952.2 692947 693741 R with TagG is involved in the export of teichoic acids; teichoic acids export protein ATP-binding subunit complement(692947..693741) Staphylococcus aureus subsp. aureus MRSA252 2859518 YP_040090.1 CDS tagG NC_002952.2 694067 694900 D Similar to Bacillus subtilis teichoic acid translocation permease TagG SW:TAGG_BACSU (P42953) (275 aa) fasta scores: E(): 7.2e-39, 37.276% id in 279 aa, and to Enterococcus faecalis ABC transporter permease TR:O88086 (EMBL:AF071085) (264 aa) fasta scores: E(): 8.5e-25, 29.963% id in 267 aa. Possible alternative translational start site at codon 8; teichoic acid ABC transporter permease 694067..694900 Staphylococcus aureus subsp. aureus MRSA252 2859517 YP_040091.1 CDS tagB NC_002952.2 694999 696102 D Similar to Bacillus subtilis teichoic acid biosynthesis protein B TagB SW:TAGB_BACSU (P27621) (381 aa) fasta scores: E(): 4.3e-26, 31.302% id in 361 aa, and to Lactococcus lactis teichoic acid biosynthesis protein B TagB TR:Q9CH14 (EMBL:AE006327) (371 aa) fasta scores: E(): 2.8e-06, 24.834% id in 302 aa. Lack of similarity at the N-terminus in comparison to other orthologues; teichoic acid biosynthesis protein 694999..696102 Staphylococcus aureus subsp. aureus MRSA252 2859515 YP_040092.1 CDS SAR0650 NC_002952.2 696099 697160 D No significant database matches to the full length CDS. N-terminus is similar to the N-terminal regions of Rhizobium meliloti succinoglycan biosynthesis protein ExoW SW:EXOW_RHIME (P33702) (319 aa) fasta scores: E(): 0.22, 25.000% id in 188 aa, and Streptococcus agalactiae N-acetylglucosaminyltransferase CpsH TR:O87182 (EMBL:AB017355) (333 aa) fasta scores: E(): 0.032, 23.207% id in 237 aa; glycosyl transferase family protein 696099..697160 Staphylococcus aureus subsp. aureus MRSA252 2861622 YP_040093.1 CDS tagD NC_002952.2 697223 697621 D Similar to Bacillus subtilis glycerol-3-phosphate cytidylyltransferase tagD SW:TAGD_BACSU (P27623) (129 aa) fasta scores: E(): 7.1e-36, 69.531% id in 128 aa. Previously sequenced as Staphylococcus aureus glycerol-3-phosphate cytidyltransferase TaqD TR:Q57197 (EMBL:X87105) (132 aa) fasta scores: E(): 6.1e-52, 99.242% id in 132 aa; glycerol-3-phosphate cytidylyltransferase 697223..697621 Staphylococcus aureus subsp. aureus MRSA252 2859516 YP_040094.1 CDS pbp4 NC_002952.2 697738 699033 R Previously sequenced as Staphylococcus aureus penicillin-binding protein 4 Pbp4 TR:P72355 (EMBL:X91786) (431 aa) fasta scores: E(): 7.3e-162, 99.072% id in 431 aa, Similar to Bacillus subtilis D-alanyl-D-alanine carboxypeptidase DacA SW:DACA_BACSU (P08750) (443 aa) fasta scores: E(): 2e-23, 30.789% id in 380 aa; penicillin-binding protein 4 complement(697738..699033) Staphylococcus aureus subsp. aureus MRSA252 2861477 YP_040095.1 CDS SAR0653 NC_002952.2 699454 701181 D Similar to Staphylococcus epidermidis lantibiotic Pep5 biosynthetic gene cluster protein PepT TR:Q54121 (EMBL:Z49865) (571 aa) fasta scores: E(): 1.2e-109, 56.348% id in 575 aa. Previously sequenced as Staphylococcus aureus ATP-binding cassette transporter A AbcA TR:P72354 (EMBL:X91786) (575 aa) fasta scores: E(): 1.5e-188, 99.826% id in 575 aa; ABC transporter ATP-binding protein 699454..701181 Staphylococcus aureus subsp. aureus MRSA252 2861623 YP_040097.1 CDS SAR0655 NC_002952.2 701540 702769 D Similar to Escherichia coli nucleoside permease NupC SW:NUPC_ECOLI (P33031) (400 aa) fasta scores: E(): 2.8e-39, 36.000% id in 400 aa, and to Bacillus subtilis hypothetical protein YxjA SW:YXJA_BACSU (P42312) (397 aa) fasta scores: E(): 7.7e-42, 46.229% id in 411 aa; Na+ dependent nucleoside transporter 701540..702769 Staphylococcus aureus subsp. aureus MRSA252 2861625 YP_040098.1 CDS SAR0656 NC_002952.2 703294 704127 D Similar to Bacillus subtilis hypothetical protein YxkD TR:P94357 (EMBL:D83026) (278 aa) fasta scores: E(): 3.5e-49, 51.460% id in 274 aa, and to Bacillus halodurans hypothetical protein BH1678 TR:Q9KC95 (EMBL:AP001512) (290 aa) fasta scores: E(): 3.5e-32, 35.507% id in 276 aa; hypothetical protein 703294..704127 Staphylococcus aureus subsp. aureus MRSA252 2861626 YP_040099.1 CDS fhuA NC_002952.2 704409 705206 D Previously sequenced as Staphylococcus aureus ferrichrome transport ATP-binding protein FhuA TR:Q9X665 (EMBL:AF132117) (265 aa) fasta scores: E(): 1.2e-89, 100.000% id in 265 aa. Similar to Bacillus subtilis ferrichrome transport ATP-binding protein FhuC SW:FHUC_BACSU (P49938) (269 aa) fasta scores: E(): 3.4e-52, 58.238% id in 261 aa; ferrichrome transport ATP-binding protein 704409..705206 Staphylococcus aureus subsp. aureus MRSA252 2860664 YP_040100.1 CDS fhuB NC_002952.2 705242 706246 D Previously sequenced as Staphylococcus aureus ferrichrome transport permease FhuB TR:Q9X664 (EMBL:AF132117) (341 aa) fasta scores: E(): 7.1e-110, 98.802% id in 334 aa. Similar to Bacillus halodurans ferrichrome ABC transporter FhuB TR:Q9KDX8 (EMBL:AP001510) (338 aa) fasta scores: E(): 1.3e-46, 40.615% id in 325 aa. CDS is 6 amino acids shorter at the N-termimus than the previously sequenced protein; ferrichrome transport permease 705242..706246 Staphylococcus aureus subsp. aureus MRSA252 2860665 YP_040101.1 CDS fhuD NC_002952.2 706243 707259 D Similar to Staphylococcus aureus ferrichrome transport permease FhuD TR:Q9X662 (EMBL:AF132117) (338 aa) fasta scores: E(): 6.7e-123, 99.112% id in 338 aa, and to Bacillus halodurans ferrichrome ABC transporter FhuG TR:Q9KDX9 (EMBL:AP001510) (334 aa) fasta scores: E(): 1e-52, 43.114% id in 334 aa; ferrichrome transport permease 706243..707259 Staphylococcus aureus subsp. aureus MRSA252 2860666 YP_040102.1 CDS SAR0660 NC_002952.2 707493 708461 D with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 707493..708461 Staphylococcus aureus subsp. aureus MRSA252 2861627 YP_040103.1 CDS SAR0661 NC_002952.2 708503 709087 D Similar to the C-terminus of Citrobacter freundii dihydroxyacetone kinase DhaK SW:DAK_CITFR (P45510) (552 aa) fasta scores: E(): 0.00012, 28.000% id in 200 aa, and to Bacillus halodurans BH3396 TR:Q9K7G5 (EMBL:AP001518) (196 aa) fasta scores: E(): 1.7e-21, 42.857% id in 189 aa. Possible subunit of a larger protein; dihydroxyacetone kinase 708503..709087 Staphylococcus aureus subsp. aureus MRSA252 2861628 YP_040104.1 CDS SAR0662 NC_002952.2 709080 709442 D Similar to Lactococcus lactis hypothetical protein YceJ TR:Q9CIV6 (EMBL:AE006262) (123 aa) fasta scores: E(): 5.3e-12, 40.741% id in 108 aa, and to Bacillus halodurans hypothetical protein BH3395 TR:Q9K7G6 (EMBL:AP001518) (128 aa) fasta scores: E(): 1.8e-09, 35.652% id in 115 aa; PTS system mannnose-specific transporter subunit IIA 709080..709442 Staphylococcus aureus subsp. aureus MRSA252 2861629 YP_040105.1 CDS SAR0663 NC_002952.2 709558 710055 D hypothetical protein 709558..710055 Staphylococcus aureus subsp. aureus MRSA252 2861630 YP_040106.1 CDS SAR0664 NC_002952.2 710511 711578 D Similar to Bacillus subtilis hypothetical protein YkvI TR:O31674 (EMBL:Z99111) (347 aa) fasta scores: E(): 7.7e-23, 27.246% id in 345 aa, and to Bacillus halodurans hypothetical protein BH4053 TR:Q9K5N5 (EMBL:AP001520) (341 aa) fasta scores: E(): 3.6e-06, 20.420% id in 333 aa; hypothetical protein 710511..711578 Staphylococcus aureus subsp. aureus MRSA252 2861631 YP_040107.1 CDS SAR0665 NC_002952.2 711729 712772 D Internal region of the CDS is similar to an internal region of Rhodococcus sp heroin esterase Her TR:O06441 (EMBL:U70619) (322 aa) fasta scores: E(): 1.3e-12, 28.017% id in 232 aa, and the C-terminal region of Clostridium perfringens lipase LipA TR:Q9XDU5 (EMBL:AB028629) (311 aa) fasta scores: E(): 6e-34, 39.163% id in 263 aa; esterase 711729..712772 Staphylococcus aureus subsp. aureus MRSA252 2861632 YP_040108.1 CDS SAR0666 NC_002952.2 713100 713528 D Poor database matches. Similar to the N-terminal region of Ureaplasma parvum pseudouridine synthase (uracil hydrolase) SfhB TR:Q9PR31 (EMBL:AE002111) (315 aa) fasta scores: E(): 5.7, 29.545% id in 132 aa; hypothetical protein 713100..713528 Staphylococcus aureus subsp. aureus MRSA252 2861633 YP_040109.1 CDS SAR0667 NC_002952.2 713726 714232 R Similar to Vibrio cholerae acetyltransferase VCA0436 TR:Q9KMC6 (EMBL:AE004377) (171 aa) fasta scores: E(): 1.8e-12, 26.829% id in 164 aa, and to Lactococcus lactis hypothetical protein YlaG TR:Q9CGJ5 (EMBL:AE006342) (162 aa) fasta scores: E(): 4.7e-12, 30.723% id in 166 aa; hypothetical protein complement(713726..714232) Staphylococcus aureus subsp. aureus MRSA252 2861634 YP_040110.1 CDS SAR0668 NC_002952.2 714345 715268 D Poor database matches. N-terminal region is similar to Staphylococcus epidermidis oxidoreductase EciO TR:O54218 (EMBL:Y14023) (247 aa) fasta scores: E(): 1.1, 21.116% id in 251 aa, and to N-terminal region of Rhizobium loti UDP-glucose 4-epimerase MLR8551 TR:BAB54411 (EMBL:AP003014) (310 aa) fasta scores: E(): 6.5, 21.875% id in 256 aa; hypothetical protein 714345..715268 Staphylococcus aureus subsp. aureus MRSA252 2861635 YP_040111.1 CDS SAR0669 NC_002952.2 715284 715958 D Probable two-component regulatory system family, response regulator protein. Similar to Bacillus halodurans two-component response regulator BH3911 TR:Q9K621 (EMBL:AP001520) (231 aa) fasta scores: E(): 9.9e-52, 56.951% id in 223 aa, and to Bacillus subtilis signal transduction regulator YtsA TR:O34951 (EMBL:AF008220) (231 aa) fasta scores: E(): 1.6e-49, 55.605% id in 223 aa; response regulator protein 715284..715958 Staphylococcus aureus subsp. aureus MRSA252 2861636 YP_040112.1 CDS SAR0670 NC_002952.2 715951 716991 D Probable two-component regulatory system family, sensor kinase. Similar to Bacillus halodurans two-component sensor histidine kinase BH3912 TR:Q9K620 (EMBL:AP001520) (334 aa) fasta scores: E(): 4.2e-38, 37.879% id in 330 aa, and to Bacillus subtilis signal transduction protein kinase YtsB TR:O35044 (EMBL:AF008220) (334 aa) fasta scores: E(): 3.1e-34, 34.848% id in 330 aa; sensor histidine kinase 715951..716991 Staphylococcus aureus subsp. aureus MRSA252 2861637 YP_040113.1 CDS SAR0671 NC_002952.2 717138 717899 D Similar to Staphylococcus aureus ABC transporter, up-regulated in vancomycin-resistant strains, VraF TR:Q9KWJ5 (EMBL:AB035453) (253 aa) fasta scores: E(): 4.3e-73, 92.885% id in 253 aa, and to Streptococcus salivarius salivaricin A ABC transporter SalX TR:Q9F444 (EMBL:AY005472) (245 aa) fasta scores: E(): 4e-29, 45.902% id in 244 aa. Similar to SAR2781, 63.200% identity (63.454% ungapped) in 250 aa overlap; ABC transporter 717138..717899 Staphylococcus aureus subsp. aureus MRSA252 2861638 YP_040114.1 CDS SAR0672 NC_002952.2 717889 719778 D Similar to Staphylococcus aureus ABC transporter, up-regulated in vancomycin-resistant strains, VraE TR:Q9KWJ6 (EMBL:AB035452) (626 aa) fasta scores: E(): 6.2e-80, 38.959% id in 634 aa, and to Bacillus subtilis ABC transporter permease YtsD TR:O34741 (EMBL:AF008220) (646 aa) fasta scores: E(): 8.5e-32, 31.846% id in 650 aa; ABC transporter permease 717889..719778 Staphylococcus aureus subsp. aureus MRSA252 2861639 YP_040115.1 CDS SAR0673 NC_002952.2 720394 721011 D Similar to Bacillus subtilis hypothetical protein YkaA SW:YKAA_BACSU (O34454) (205 aa) fasta scores: E(): 3.2e-31, 46.829% id in 205 aa, and to Deinococcus radiodurans conserved hypothetical protein DR0924 TR:Q9RVU8 (EMBL:AE001945) (212 aa) fasta scores: E(): 5.8e-10, 25.481% id in 208 aa; hypothetical protein 720394..721011 Staphylococcus aureus subsp. aureus MRSA252 2861640 YP_040116.1 CDS SAR0674 NC_002952.2 721027 722034 D Similar to Bacillus subtilis probable low-affinity inorganic phosphate transporter Pit SW:PIT_BACSU (O34436) (328 aa) fasta scores: E(): 5.6e-79, 68.932% id in 309 aa, and to Streptomyces coelicolor phosphate transport protein PitH TR:Q9KZW3 (EMBL:AL353816) (332 aa) fasta scores: E(): 3.3e-55, 45.045% id in 333 aa; phosphate transport protein 721027..722034 Staphylococcus aureus subsp. aureus MRSA252 2859727 YP_040117.1 CDS SAR0675 NC_002952.2 722621 723418 R Similar to Staphylococcus carnosus secreted protein precursor SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 1.2e-19, 35.816% id in 282 aa, and to Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 2.4e-18, 36.330% id in 267 aa; hypothetical protein complement(722621..723418) Staphylococcus aureus subsp. aureus MRSA252 2859723 YP_040118.1 CDS SAR0676 NC_002952.2 723779 724423 D Similar to Bacillus subtilis hypothetical protein YetJ TR:O31539 (EMBL:Z99107) (214 aa) fasta scores: E(): 1.3e-07, 22.886% id in 201 aa, and to Helicobacter pylori J99 hypothetical protein JHP0854 TR:Q9ZKT1 (EMBL:AE001515) (230 aa) fasta scores: E(): 1.3e-07, 22.488% id in 209 aa; hypothetical protein 723779..724423 Staphylococcus aureus subsp. aureus MRSA252 2861643 YP_040119.1 CDS SAR0679 NC_002952.2 727339 727764 D Poor database matches. Similar to Staphylococcus aureus staphylococcal accessory regulator A homologue SarR TR:Q9F0R1 (EMBL:AF207701) (115 aa) fasta scores: E(): 3.3, 21.359% id in 103 aa; hypothetical protein 727339..727764 Staphylococcus aureus subsp. aureus MRSA252 2861645 YP_040120.1 CDS SAR0680 NC_002952.2 727954 728670 D Similar to Bacillus halodurans BH3259 TR:Q9K7V0 (EMBL:AP001518) (239 aa) fasta scores: E(): 3.6e-63, 74.262% id in 237 aa, and to Bacillus subtilis hypothetical protein YeeI SW:YEEI_BACSU (O31509) (240 aa) fasta scores: E(): 9.9e-61, 72.689% id in 238 aa; hypothetical protein 727954..728670 Staphylococcus aureus subsp. aureus MRSA252 2861646 YP_040121.1 CDS SAR0681 NC_002952.2 728670 729143 D Similar to Synechocystis sp hypothetical protein SLL1188 TR:P72845 (EMBL:D90901) (164 aa) fasta scores: E(): 6.5e-24, 42.405% id in 158 aa, and to Streptococcus pneumoniae conserved hypothetical protein SP2081 TR:AAK76141 (EMBL:AE007497) (153 aa) fasta scores: E(): 2e-25, 48.000% id in 150 aa; hypothetical protein 728670..729143 Staphylococcus aureus subsp. aureus MRSA252 2861647 YP_040122.1 CDS SAR0682 NC_002952.2 729496 730140 D N-terminal region is similar to Pyrococcus horikoshii hypothetical protein PH1613 ph1613 TR:O59236 (EMBL:AP000006) (166 aa) fasta scores: E(): 4.9e-06, 29.070% id in 172 aa, and to Pyrococcus abyssi hypothetical protein PAB0381 TR:Q9V175 (EMBL:AJ248284) (171 aa) fasta scores: E(): 3.5e-05, 29.609% id in 179 aa; hypothetical protein 729496..730140 Staphylococcus aureus subsp. aureus MRSA252 2861648 YP_040123.1 CDS SAR0683 NC_002952.2 730258 731124 D N-terminus is similar to the N-terminal region of Erwinia carotovora hydrogen peroxide-inducible genes activator OxyR SW:OXYR_ERWCA (P71318) (302 aa) fasta scores: E(): 2.5e-09, 23.577% id in 246 aa. Full length CDS is similar to Bacillus halodurans transcriptional regulator BH1787 TR:Q9KBY7 (EMBL:AP001513) (280 aa) fasta scores: E(): 1.7e-33, 35.125% id in 279 aa; LysR family regulatory protein 730258..731124 Staphylococcus aureus subsp. aureus MRSA252 2861649 YP_040124.1 CDS SAR0684 NC_002952.2 731256 732476 D Similar to Escherichia coli sugar efflux transporter C SetC SW:SETC_ECOLI (P31436) (394 aa) fasta scores: E(): 7.1e-26, 27.559% id in 381 aa, and to Erwinia chrysanthemi sugar efflux transporter SotA SW:SOTA_ERWCH (Q9S3K0) (393 aa) fasta scores: E(): 1.4e-25, 29.759% id in 373 aa; sugar efflux transporter 731256..732476 Staphylococcus aureus subsp. aureus MRSA252 2861650 YP_040125.1 CDS SAR0687 NC_002952.2 734448 735122 D Similar to Staphylococcus aureus plasmid (pSK41) transposase TnpG TR:Q53697 (EMBL:X53951) (224 aa) fasta scores: E(): 4.8e-79, 88.839% id in 224 aa, and to Staphylococcus epidermidis plasmid (pSK818) insertion sequence IS257(818C) transposase Tnp TR:P97218 (EMBL:U40386) (224 aa) fasta scores: E(): 1.8e-78, 88.839% id in 224 aa; transposase 734448..735122 Staphylococcus aureus subsp. aureus MRSA252 2861653 YP_040126.1 CDS SAR0688 NC_002952.2 735157 735369 R hypothetical protein complement(735157..735369) Staphylococcus aureus subsp. aureus MRSA252 2859765 YP_040127.1 CDS arsR1 NC_002952.2 736085 736399 D Highly similar to Staphylococcus aureus plasmid pI258 arsenical resistance operon repressor ArsR SW:ARSR_STAAU (P30338) (104 aa) fasta scores: E(): 2.9e-40, 99.038% id in 104 aa, and to Staphylococcus xylosus plasmid pSX267 arsenical resistance operon repressor ArsR SW:ARSR_STAXY (Q01256) (104 aa) fasta scores: E(): 5.9e-34, 85.577% id in 104 aa. Similar to SAR1855, 75.000% identity (75.000% ungapped) in 104 aa overlap; arsenical resistance operon repressor 1 736085..736399 Staphylococcus aureus subsp. aureus MRSA252 2859867 YP_040128.1 CDS arsB1 NC_002952.2 736399 737688 D Highly similar to Staphylococcus aureus arsenical pump membrane protein ArsB SW:ARSB_STAAU (P30329) (429 aa) fasta scores: E(): 2e-142, 99.301% id in 429 aa, and to Staphylococcus xylosus arsenical pump membrane protein ArsB SW:ARSB_STAXY (Q01255) (429 aa) fasta scores: E(): 1.5e-139, 96.737% id in 429 aa. Similar to SAR1856, 79.254% identity (79.254% ungapped) in 429 aa overlap; arsenical pump membrane protein 1 736399..737688 Staphylococcus aureus subsp. aureus MRSA252 2859864 YP_040129.1 CDS arsC NC_002952.2 737706 738101 D catalyzes the reduction of arsenate to arsenite; also can dephosphorylate tyrosine phosphorylated proteins, aryl phosphates, and acyl phosphates; arsenate reductase 737706..738101 Staphylococcus aureus subsp. aureus MRSA252 2859866 YP_040130.1 CDS SAR0693 NC_002952.2 738308 738466 D Similar to Mycoplasma pulmonis hypothetical protein MYPU_3400 TR:CAC13513 (EMBL:AL445564) (49 aa) fasta scores: E(): 1.6, 36.957% id in 46 aa; hypothetical protein 738308..738466 Staphylococcus aureus subsp. aureus MRSA252 2859767 YP_040131.1 CDS SAR0694 NC_002952.2 738481 738774 D Similar to Lactococcus lactis lactococcin 972 precursor LclA TR:O86283 (EMBL:AJ002203) (91 aa) fasta scores: E(): 0.019, 30.769% id in 78 aa, and to the N-terminal region of Bacillus subtilis endopeptidase precursor LytF TR:O07532 (EMBL:Y14079) (488 aa) fasta scores: E(): 3.1, 36.471% id in 85 aa; hypothetical protein 738481..738774 Staphylococcus aureus subsp. aureus MRSA252 2859768 YP_040132.1 CDS SAR0695 NC_002952.2 738849 740783 D Similar to Lactococcus lactis plasmid pBL1 hypothetical lactococcin 972 immunity protein LclB TR:Q9L651 (EMBL:AF242367) (648 aa) fasta scores: E(): 1.4e-14, 22.356% id in 662 aa, and to Lactococcus lactis hypothetical protein YujE TR:Q9CE29 (EMBL:AE006431) (660 aa) fasta scores: E(): 5.4e-08, 19.288% id in 674 aa; hypothetical protein 738849..740783 Staphylococcus aureus subsp. aureus MRSA252 2859769 YP_040133.1 CDS SAR0696 NC_002952.2 740787 741098 D Poor database matches. Similar to Bacillus subtilis hypothetical protein YxeA SW:YXEA_BACSU (P54940) (115 aa) fasta scores: E(): 0.0026, 30.841% id in 107 aa; hypothetical protein 740787..741098 Staphylococcus aureus subsp. aureus MRSA252 2859770 YP_040134.1 CDS SAR0697 NC_002952.2 741110 741736 D Similar to Lactococcus lactis hypothetical ATP binding protein TR:Q9L650 (EMBL:AF242367) (207 aa) fasta scores: E(): 1e-26, 49.758% id in 207 aa, and to Streptococcus pneumoniae hypothetical protein TR:Q9ZHB1 (EMBL:AF068902) (213 aa) fasta scores: E(): 4.3e-25, 45.238% id in 210 aa; ABC transporter ATP-binding protein 741110..741736 Staphylococcus aureus subsp. aureus MRSA252 2859771 YP_040135.1 CDS SAR0698 NC_002952.2 742098 743744 D Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 6.9e-199, 99.270% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 2.8e-99, 52.115% id in 520 aa; transposase 742098..743744 Staphylococcus aureus subsp. aureus MRSA252 2859772 YP_040136.1 CDS SAR0702 NC_002952.2 745289 745432 R No significant database matches. Doubtful CDS; hypothetical protein complement(745289..745432) Staphylococcus aureus subsp. aureus MRSA252 2859774 YP_040137.1 CDS SAR0703 NC_002952.2 745474 746334 D Similar to Staphylococcus epidermidis plasmid pSK639 replication initiation protein Orf287 TR:P95741 (EMBL:U40259) (287 aa) fasta scores: E(): 5.7e-76, 76.224% id in 286 aa, and to Lactobacillus acidophilus plasmid pLA103 replication protein RepA TR:Q52180 (EMBL:D55703) (282 aa) fasta scores: E(): 1.2e-28, 36.842% id in 285 aa; plasmid replication initiation protein 745474..746334 Staphylococcus aureus subsp. aureus MRSA252 2859775 YP_040138.1 CDS SAR0704 NC_002952.2 746421 746762 D Similar to Lactococcus lactis transcriptional regulator YabB TR:Q9CJI6 (EMBL:AE006240) (107 aa) fasta scores: E(): 6.2e-09, 35.714% id in 112 aa, and to the N-terminal region of Streptococcus pyogenes hypothetical protein SPY1834 TR:Q99Y76 (EMBL:AE006610) (195 aa) fasta scores: E(): 3.2e-07, 34.259% id in 108 aa; DNA-binding protein 746421..746762 Staphylococcus aureus subsp. aureus MRSA252 2859776 YP_040139.1 CDS SAR0705 NC_002952.2 746836 746967 D No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 746836..746967 Staphylococcus aureus subsp. aureus MRSA252 2859777 YP_040140.1 CDS SAR0706 NC_002952.2 746977 747081 R No significant database matches. Similar to SAR1888, 50.000% identity (50.000% ungapped) in 28 aa overlap, and to SAR0716, 55.556% identity (55.556% ungapped) in 27 aa overlap; hypothetical protein complement(746977..747081) Staphylococcus aureus subsp. aureus MRSA252 2859778 YP_040141.1 CDS SAR0710 NC_002952.2 748482 748598 D hypothetical protein 748482..748598 Staphylococcus aureus subsp. aureus MRSA252 2859780 YP_040142.1 CDS SAR0714 NC_002952.2 750428 750637 D Poor database matches. Similar to internal region of Campylobacter jejuni arsenical pump membrane protein ArsB TR:Q9PNA8 (EMBL:AL139077) (428 aa) fasta scores: E(): 7.1, 33.333% id in 66 aa; hypothetical protein 750428..750637 Staphylococcus aureus subsp. aureus MRSA252 2859783 YP_040143.1 CDS SAR0715 NC_002952.2 750819 751142 R Poor database matches Similar to the C-terminal regions of Streptomyces coelicolor hypothetical protein SC5G9.13c TR:Q9RL13 (EMBL:AL117385) (122 aa) fasta scores: E(): 0.97, 28.571% id in 91 aa, and Rhizobium loti hypothetical protein MLR1105 TR:BAB48553 (EMBL:AP002996) (210 aa) fasta scores: E(): 1.6, 29.885% id in 87 aa; hypothetical protein complement(750819..751142) Staphylococcus aureus subsp. aureus MRSA252 2859784 YP_040144.1 CDS SAR0716 NC_002952.2 751371 751463 D Nosignificant database matches. Similar to SAR1888, 72.414% identity (72.414% ungapped) in 29 aa overlap, and to SAR0706, 55.556% identity (55.556% ungapped) in 27 aa overlap; hypothetical protein 751371..751463 Staphylococcus aureus subsp. aureus MRSA252 2859785 YP_040145.1 CDS SAR0717 NC_002952.2 751765 752586 R Similar to Rhodospirillum rubrum rubisco operon transcriptional regulator CbbR SW:CBBR_RHORU (P52595) (298 aa) fasta scores: E(): 1.2e-07, 26.087% id in 276 aa, and to Staphylococcus xylosus hypothetical transcriptional regulator SW:YLAC_STAXY (O33812) (270 aa) fasta scores: E(): 8.9e-68, 70.943% id in 265 aa; LysR family regulatory protein complement(751765..752586) Staphylococcus aureus subsp. aureus MRSA252 2859786 YP_040146.1 CDS SAR0718 NC_002952.2 752711 753706 D Similar to Escherichia coli hypothetical protein YeiH SW:YEIH_ECOLI (P33019) (349 aa) fasta scores: E(): 5.7e-28, 31.429% id in 315 aa, and to Rhizobium loti hypothetical protein MLR2225 TR:BAB49407 (EMBL:AP002999) (325 aa) fasta scores: E(): 1.1e-26, 27.900% id in 319 aa. Similar to SAR0338, 68.085% identity (68.085% ungapped) in 329 aa overlap; hypothetical protein 752711..753706 Staphylococcus aureus subsp. aureus MRSA252 2859787 YP_040147.1 CDS SAR0719 NC_002952.2 754041 754616 R Similar to Staphylococcus aureus plasmid pI9789 transposon Tn552 resolvase TnpR SW:BINL_STAAU (P18358) (197 aa) fasta scores: E(): 1e-66, 93.194% id in 191 aa, and to Staphylococcus epidermidis plasmid pST6 resolvase/integrase BinR TR:AAK38454 (EMBL:AY028779) (192 aa) fasta scores: E(): 2.5e-66, 92.708% id in 192 aa. Similar to SAR1828, 94.764% identity (94.764% ungapped) in 191 aa overlap; resolvase complement(754041..754616) Staphylococcus aureus subsp. aureus MRSA252 2859788 YP_040148.1 CDS SAR0720 NC_002952.2 754883 756928 D Similar to Streptococcus mutans copper exporting P-type ATPase CopA TR:Q9F682 (EMBL:AF296446) (742 aa) fasta scores: E(): 1.2e-66, 34.431% id in 668 aa, and to Enterococcus hirae probable copper exporting ATPase B CopB SW:COPB_ENTHR (P05425) (745 aa) fasta scores: E(): 2.2e-135, 57.122% id in 681 aa; cation exporting ATPase 754883..756928 Staphylococcus aureus subsp. aureus MRSA252 2859789 YP_040149.1 CDS SAR0721 NC_002952.2 756943 758376 D Similar to Campylobacter jejuni periplasmic oxidoreductase CJ1516 TR:Q9PME8 (EMBL:AL139078) (513 aa) fasta scores: E(): 9.6e-22, 31.673% id in 502 aa, and to Escherichia coli probable blue-copper protein precursor YacK SW:YACK_ECOLI (P36649) (516 aa) fasta scores: E(): 2.8e-30, 35.931% id in 462 aa; multicopper oxidase 756943..758376 Staphylococcus aureus subsp. aureus MRSA252 2859790 YP_040150.1 CDS SAR0722 NC_002952.2 758443 760089 R Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 8.5e-195, 97.810% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 8.1e-99, 52.115% id in 520 aa; transposase complement(758443..760089) Staphylococcus aureus subsp. aureus MRSA252 2859791 YP_040151.1 CDS cadA NC_002952.2 760452 762632 R Similar to Staphylococcus aureus plasmid pI258 probable cadmium-transporting ATPase CadA SW:CADA_STAAU (P20021) (727 aa) fasta scores: E(): 0, 91.586% id in 725 aa, and to Bacillus firmus probable cadmium-transporting ATPase CadA SW:CADA_BACFI (P30336) (723 aa) fasta scores: E(): 1.5e-213, 81.354% id in 724 aa; cadmium-transporting ATPase complement(760452..762632) Staphylococcus aureus subsp. aureus MRSA252 2859821 YP_040152.1 CDS cadC NC_002952.2 762625 762990 R Similar to Staphylococcus aureus cadmium resistance protein CadC SW:CADF_STAAU (P37374) (121 aa) fasta scores: E(): 1.6e-43, 98.347% id in 121 aa, and to Listeria monocytogenes plasmid pLm74 cadmium efflux system accessory protein CadC SW:CADC_LISMO (Q56405) (119 aa) fasta scores: E(): 1.1e-19, 53.571% id in 112 aa; cadmium efflux system accessory protein complement(762625..762990) Staphylococcus aureus subsp. aureus MRSA252 2860182 YP_040153.1 CDS SAR0725 NC_002952.2 763228 763605 R Similar to Staphylococcus aureus transposase C of transposon Tn554 TR:BAB47607 (EMBL:AB037671) (125 aa) fasta scores: E(): 2e-36, 98.400% id in 125 aa; Tn554 transposase C complement(763228..763605) Staphylococcus aureus subsp. aureus MRSA252 2859792 YP_040154.1 CDS SAR0726 NC_002952.2 763700 764374 D Similar to Staphylococcus aureus transposase for insertion sequence-like element IS431mec TR:BAA82238 (EMBL:D86934) (224 aa) fasta scores: E(): 2.4e-78, 88.393% id in 224 aa, and to Staphylococcus epidermidis plasmid pSK818 transposase Tnp TR:P97218 (EMBL:U40386) (224 aa) fasta scores: E(): 1.8e-78, 88.839% id in 224 aa; transposase 763700..764374 Staphylococcus aureus subsp. aureus MRSA252 2859793 YP_040155.1 CDS SAR0728 NC_002952.2 765037 765726 R Poor database matches. Similar to Bacillus halodurans BH0407 TR:Q9KFS0 (EMBL:AP001508) (228 aa) fasta scores: E(): 4.5e-05, 23.445% id in 209 aa; hypothetical protein complement(765037..765726) Staphylococcus aureus subsp. aureus MRSA252 2859794 YP_040156.1 CDS SAR0729 NC_002952.2 765853 766296 D C-terminus is similar to the C-terminal regions of Acinetobacter sp aminoglycoside resistance protein Aac(6')-Ik TR:Q44246 (EMBL:L29510) (145 aa) fasta scores: E(): 0.021, 31.373% id in 102 aa, and to Vibrio cholerae acetyltransferase VC1341 TR:Q9KSB7 (EMBL:AE004214) (158 aa) fasta scores: E(): 0.042, 26.357% id in 129 aa; acetyltransferase 765853..766296 Staphylococcus aureus subsp. aureus MRSA252 2859795 YP_040157.1 CDS SAR0730 NC_002952.2 766363 766752 D No significant database matches. Lysine and aspartic acid rich protein, 27.1% and 15.5% of the total amino acid content respectively. Contains coiled-coiled domain, residues 29 to 57; hypothetical protein 766363..766752 Staphylococcus aureus subsp. aureus MRSA252 2859796 YP_040158.1 CDS SAR0731 NC_002952.2 766890 767189 D hypothetical protein 766890..767189 Staphylococcus aureus subsp. aureus MRSA252 2859797 YP_040159.1 CDS SAR0732 NC_002952.2 767269 767811 D Similar to Proteus mirabilis acetyl transferase Pat TR:O86434 (EMBL:AJ000084) (185 aa) fasta scores: E(): 6.4e-19, 42.529% id in 174 aa, and to Streptomyces coelicolor acetyltranferase SC5C11.04c TR:Q9L168 (EMBL:AL158060) (183 aa) fasta scores: E(): 3.7e-16, 37.853% id in 177 aa; acetyltransferase 767269..767811 Staphylococcus aureus subsp. aureus MRSA252 2859798 YP_040160.1 CDS SAR0733 NC_002952.2 767906 768472 R Similar to Bacillus halodurans hypothetical protein BH3084 TR:Q9K8C2 (EMBL:AP001517) (187 aa) fasta scores: E(): 1e-33, 49.189% id in 185 aa, and to Bacillus subtilis hypothetical protein YvdD TR:O06986 (EMBL:Z94043) (191 aa) fasta scores: E(): 2.1e-31, 48.603% id in 179 aa; hypothetical protein complement(767906..768472) Staphylococcus aureus subsp. aureus MRSA252 2859799 YP_040161.1 CDS SAR0734 NC_002952.2 768474 768932 R Similar to Listeria monocytogenes hypothetical protein SW:YP17_LISMO (P52309) (149 aa) fasta scores: E(): 9.4e-14, 34.752% id in 141 aa, and to Bacillus halodurans hypothetical protein BH1374 TR:Q9KD45 (EMBL:AP001511) (157 aa) fasta scores: E(): 2.2e-11, 32.192% id in 146 aa; hypothetical protein complement(768474..768932) Staphylococcus aureus subsp. aureus MRSA252 2861398 YP_040162.1 CDS SAR0735 NC_002952.2 768935 769618 R No significant database matches. CDS is lysine rich, 23.3% of the total amino acid content; hypothetical protein complement(768935..769618) Staphylococcus aureus subsp. aureus MRSA252 2861399 YP_040163.1 CDS uppP NC_002952.2 769790 770665 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase complement(769790..770665) Staphylococcus aureus subsp. aureus MRSA252 2859884 YP_040164.1 CDS SAR0737 NC_002952.2 770884 772515 D Similar to Escherichia coli transport ATP-binding protein CydD SW:CYDD_ECOLI (P29018) (588 aa) fasta scores: E(): 3.6e-22, 28.799% id in 566 aa, and to Bacillus subtilis transport ATP-binding protein CydC SW:CYDC_BACSU (P94366) (567 aa) fasta scores: E(): 2.4e-28, 27.839% id in 546 aa; ABC transporter ATP-binding protein 770884..772515 Staphylococcus aureus subsp. aureus MRSA252 2861400 YP_040165.1 CDS SAR0738 NC_002952.2 772512 774185 D Similar to Escherichia coli transport ATP-binding protein CydC SW:CYDC_ECOLI (P23886) (573 aa) fasta scores: E(): 3.4e-33, 30.195% id in 563 aa, and to Bacillus halodurans ABC transporter ATP-binding protein BH3972 TR:Q9K5W5 (EMBL:AP001520) (575 aa) fasta scores: E(): 6.1e-48, 32.491% id in 554 aa; ABC transporter ATP-binding protein 772512..774185 Staphylococcus aureus subsp. aureus MRSA252 2861401 YP_040166.1 CDS SAR0739 NC_002952.2 774312 774755 R Similar to Bacillus subtilis hypothetical protein YkmA TR:O34777 (EMBL:AJ002571) (147 aa) fasta scores: E(): 2e-14, 36.879% id in 141 aa, and to Streptomyces coelicolor regulatory protein SCE50.15 TR:Q9L048 (EMBL:AL163672) (168 aa) fasta scores: E(): 3.5e-14, 39.007% id in 141 aa; MarR family regulatory protein complement(774312..774755) Staphylococcus aureus subsp. aureus MRSA252 2861402 YP_040167.1 CDS SAR0740 NC_002952.2 774982 775908 D Similar to Bacillus halodurans hypothetical protein BH0366 TR:Q9KFV5 (EMBL:AP001508) (311 aa) fasta scores: E(): 4.7e-27, 31.190% id in 311 aa, and to Aquifex aeolicus cobalamin synthesis related protein CobW TR:O66539 (EMBL:AE000675) (292 aa) fasta scores: E(): 1.6e-16, 29.682% id in 283 aa; cobalamin synthesis protein 774982..775908 Staphylococcus aureus subsp. aureus MRSA252 2861403 YP_040168.1 CDS SAR0741 NC_002952.2 776011 776919 D Similar to Bacillus subtilis hypothetical oxidoreductase YcsN SW:YCSN_BACSU (P42972) (300 aa) fasta scores: E(): 4e-51, 47.195% id in 303 aa, and to Escherichia coli hypothetical oxidoreductase YdhF SW:YDHF_ECOLI (P76187) (298 aa) fasta scores: E(): 1.1e-44, 43.151% id in 292 aa; aldo/keto reductase 776011..776919 Staphylococcus aureus subsp. aureus MRSA252 2861404 YP_040169.1 CDS SAR0742 NC_002952.2 776954 777241 D Poor database matches. Similar to an internal region of Methanococcus jannaschii hypothetical protein MJ0420 SW:Y420_METJA (Q57863) (380 aa) fasta scores: E(): 0.11, 32.143% id in 84 aa; hypothetical protein 776954..777241 Staphylococcus aureus subsp. aureus MRSA252 2861405 YP_040170.1 CDS SAR0743 NC_002952.2 777524 779077 D Similar to Escherichia coli citrate carrier protein CitT SW:CITT_ECOLI (P77405) (487 aa) fasta scores: E(): 1.1e-26, 23.400% id in 500 aa, and to Alcaligenes eutrophus membrane protein SW:MEMP_ALCEU (Q07252) (513 aa) fasta scores: E(): 7.1e-75, 47.561% id in 492 aa; sodium:sulfate symporter protein 777524..779077 Staphylococcus aureus subsp. aureus MRSA252 2861406 YP_040171.1 CDS SAR0744 NC_002952.2 779163 780536 D Similar to Escherichia coli deoxyribodipyrimidine photolyase PhrB SW:PHR_ECOLI (P00914) (472 aa) fasta scores: E(): 8.3e-37, 33.408% id in 449 aa, and to Streptococcus pyogenes deoxyribodipyrimidine photolyase Phr TR:Q99YX0 (EMBL:AE006584) (469 aa) fasta scores: E(): 1.8e-52, 34.402% id in 468 aa; DNA photolyase 779163..780536 Staphylococcus aureus subsp. aureus MRSA252 2861407 YP_040172.1 CDS SAR0745 NC_002952.2 780691 780975 R Poor database matches. Similar to an internal region of Bacillus halodurans hypothetical protein BH0447 TR:Q9KFN2 (EMBL:AP001508) (247 aa) fasta scores: E(): 4.7, 20.225% id in 89 aa; hypothetical protein complement(780691..780975) Staphylococcus aureus subsp. aureus MRSA252 2861408 YP_040173.1 CDS SAR0746 NC_002952.2 780972 781592 R Similar to Synechocystis sp hypothetical protein SLL0397 TR:Q55732 (EMBL:D64002) (217 aa) fasta scores: E(): 7.3e-07, 30.055% id in 183 aa, and to Treponema pallidum conserved hypothetical integral membrane protein TP0033 TR:O83076 (EMBL:AE001188) (203 aa) fasta scores: E(): 5.2e-05, 30.286% id in 175 aa; hypothetical protein complement(780972..781592) Staphylococcus aureus subsp. aureus MRSA252 2861409 YP_040174.1 CDS SAR0747 NC_002952.2 781776 782198 R Similar to Archaeoglobus fulgidus hypothetical protein AF0104 TR:O30132 (EMBL:AE001099) (138 aa) fasta scores: E(): 9.2e-11, 34.127% id in 126 aa, and to Halobacterium sp hypothetical protein VNG2339C TR:Q9HMX7 (EMBL:AE005116) (139 aa) fasta scores: E(): 2.8e-08, 31.967% id in 122 aa; hypothetical protein complement(781776..782198) Staphylococcus aureus subsp. aureus MRSA252 2861410 YP_040175.1 CDS norA NC_002952.2 782414 783580 D Highly similar to Staphylococcus aureus fluoroquinolone resistance protein NorA1199 TR:Q03325 (EMBL:M80252) (388 aa) fasta scores: E(): 6.4e-132, 96.134% id in 388 aa. Similar to Bacillus subtilis multidrug resistance protein 1 Bmr SW:BMR1_BACSU (P33449) (389 aa) fasta scores: E(): 1.7e-61, 44.125% id in 383 aa; fluoroquinolone resistance protein 782414..783580 Staphylococcus aureus subsp. aureus MRSA252 2859165 YP_040176.1 CDS SAR0749 NC_002952.2 783865 784329 D Poor database matches. Similar to Legionella pneumophila immunogenic protein TR:O32829 (EMBL:Z97066) (136 aa) fasta scores: E(): 3.6, 22.069% id in 145 aa; hypothetical protein 783865..784329 Staphylococcus aureus subsp. aureus MRSA252 2861411 YP_040177.1 CDS SAR0750 NC_002952.2 784503 784985 D Similar to Enterococcus faecalis regulatory protein EbsC SW:EBSC_ENTFA (P36922) (164 aa) fasta scores: E(): 7.2e-21, 44.375% id in 160 aa, and to Bacillus subtilis hypothetical protein YjdI TR:O31650 (EMBL:Z99110) (159 aa) fasta scores: E(): 1.3e-21, 46.939% id in 147 aa; hypothetical protein 784503..784985 Staphylococcus aureus subsp. aureus MRSA252 2861412 YP_040178.1 CDS SAR0751 NC_002952.2 785238 785999 D Similar to Escherichia coli aga operon transcriptional repressor AgaR SW:AGAR_ECOLI (P42902) (269 aa) fasta scores: E(): 1.2e-17, 28.571% id in 245 aa, and to Bacillus halodurans transcriptional repressor BH0826 TR:Q9KEM6 (EMBL:AP001510) (251 aa) fasta scores: E(): 5.3e-38, 45.082% id in 244 aa; DeoR ramily regulatory protein 785238..785999 Staphylococcus aureus subsp. aureus MRSA252 2861413 YP_040179.1 CDS SAR0752 NC_002952.2 785996 786916 D Similar to Streptococcus mutans tagatose-6-phosphate kinase LacC SW:LACC_STRMU (P26421) (310 aa) fasta scores: E(): 1.8e-25, 35.789% id in 285 aa, and to Bacillus subtilis 1-phosphofructokinase FruK SW:K1PF_BACSU (O31714) (303 aa) fasta scores: E(): 7.7e-47, 46.865% id in 303 aa; phosphofructokinase 785996..786916 Staphylococcus aureus subsp. aureus MRSA252 2861414 YP_040180.1 CDS fruA NC_002952.2 786922 788880 D Similar to Rhodobacter capsulatus PTS system, fructose-specific IIBC component FruA SW:PTFB_RHOCA (P23387) (578 aa) fasta scores: E(): 7.7e-66, 40.709% id in 592 aa. Previously sequenced as Staphylococcus aureus fructose specific permease FruA TR:Q9KWK0 (EMBL:AB035450) (646 aa) fasta scores: E(): 8.9e-218, 98.762% id in 646 aa; PTS transport system, fructose-specific IIABC component 786922..788880 Staphylococcus aureus subsp. aureus MRSA252 2860682 YP_040181.1 CDS SAR0754 NC_002952.2 789183 790364 D Similar to Vibrio furnissii N-acetylglucosamine-6-phosphate deacetylase ManD SW:NAGA_VIBFU (P96166) (399 aa) fasta scores: E(): 3.9e-37, 36.000% id in 375 aa, and to Bacillus subtilis N-acetylglucosamine-6-phosphate deacetylase NagA SW:NAGA_BACSU (O34450) (396 aa) fasta scores: E(): 1.7e-56, 45.547% id in 393 aa; N-acetylglucosamine-6-phosphate deacetylase 789183..790364 Staphylococcus aureus subsp. aureus MRSA252 2861415 YP_040182.1 CDS SAR0755 NC_002952.2 790585 791934 D Similar to Bacillus subtilis hypothetical protein YhdP SW:YHDP_BACSU (O07585) (444 aa) fasta scores: E(): 1.3e-74, 47.529% id in 425 aa, and to Bacillus subtilis hypothetical protein YrkA SW:YRKA_BACSU (P54428) (434 aa) fasta scores: E(): 6.4e-69, 47.382% id in 401 aa; hypothetical protein 790585..791934 Staphylococcus aureus subsp. aureus MRSA252 2861416 YP_040183.1 CDS SAR0756 NC_002952.2 792148 792987 D Similar to Trypanosoma brucei prostaglandin F synthase TR:Q9GV41 (EMBL:AB034727) (276 aa) fasta scores: E(): 3.9e-43, 47.547% id in 265 aa, and to Streptomyces coelicolor oxidoreductase SC4B5.01C TR:Q9ZBW7 (EMBL:AL034443) (277 aa) fasta scores: E(): 2.7e-50, 50.562% id in 267 aa; aldo/keto reductase 792148..792987 Staphylococcus aureus subsp. aureus MRSA252 2861417 YP_040184.1 CDS SAR0757 NC_002952.2 793119 794102 D Similar to bacteriophage SfII bactoprenol glucosyl transferase GtrB SW:GTRB_BPSF2 (O21943) (309 aa) fasta scores: E(): 2.4e-42, 44.695% id in 311 aa, and to Bacillus subtilis hypothetical protein CsbB SW:CSBB_BACSU (Q45539) (329 aa) fasta scores: E(): 3.8e-61, 50.467% id in 321 aa; glucosyl transferase 793119..794102 Staphylococcus aureus subsp. aureus MRSA252 2861418 YP_040185.1 CDS saeS NC_002952.2 794174 795229 R Two-component regulatory system family, sensor kinase. Similar to Staphylococcus aureus exoproteins regulating histidine protein kinase SaeS TR:Q9S4L8 (EMBL:AF129010) (353 aa) fasta scores: E(): 1.6e-100, 88.952% id in 353 aa, and to Streptococcus pneumoniae histidine kinase Hk08 TR:Q9S1J1 (EMBL:AJ006397) (350 aa) fasta scores: E(): 2.6e-28, 34.097% id in 349 aa; histidine kinase complement(794174..795229) Staphylococcus aureus subsp. aureus MRSA252 2861464 YP_040186.1 CDS saeR NC_002952.2 795229 795915 R Two-component regulatory system family, response regulator protein. Similar to Staphylococcus aureus exoproteins controlling response regulator SaeR TR:Q9S4L9 (EMBL:AF129010) (228 aa) fasta scores: E(): 2.1e-86, 98.246% id in 228 aa, and to Streptococcus pneumoniae response regulator Rr08 TR:Q9S1J2 (EMBL:AJ006397) (232 aa) fasta scores: E(): 4.9e-37, 46.256% id in 227 aa; response regulator protein complement(795229..795915) Staphylococcus aureus subsp. aureus MRSA252 2861463 YP_040187.1 CDS SAR0760 NC_002952.2 795890 796363 R Poor database matches. N-terminus is similar to the N-terminal region of Bacillus halodurans hypothetical protein BH2253 TR:Q9KAN4 (EMBL:AP001514) (173 aa) fasta scores: E(): 3.3e-05, 32.479% id in 117 aa; hypothetical protein complement(795890..796363) Staphylococcus aureus subsp. aureus MRSA252 2861419 YP_040188.1 CDS SAR0761 NC_002952.2 796705 797145 R Poor database matches Similar to the N-terminal region of Staphylococcus aureus pathogenicity island hypothetical protein Orf3 TR:Q9F0L5 (EMBL:AF217235) (170 aa) fasta scores: E(): 0.59, 28.276% id in 145 aa, and to an internal region of Drosophila melanogaster hypothetical protein CG5175 TR:Q9VEN4 (EMBL:AE003716) (566 aa) fasta scores: E(): 1.3, 30.986% id in 142 aa; hypothetical protein complement(796705..797145) Staphylococcus aureus subsp. aureus MRSA252 2861420 YP_040189.1 CDS SAR0762 NC_002952.2 797425 798009 R Poor database matches. Similar to N-terminal regions of Campylobacter jejuni enterochelin uptake permease CeuC TR:Q9PMU6 (EMBL:AL139078) (312 aa) fasta scores: E(): 7.3, 26.042% id in 192 aa, and Thermoplasma volcanium hypothetical protein TVG0355256 TR:BAB59507 (EMBL:AP000992) (486 aa) fasta scores: E(): 8.8, 21.693% id in 189 aa; hypothetical protein complement(797425..798009) Staphylococcus aureus subsp. aureus MRSA252 2861421 YP_040190.1 CDS SAR0763 NC_002952.2 798108 798821 R Similar to Bacillus subtilis hypothetical protein YkvL TR:O31677 (EMBL:Z99111) (243 aa) fasta scores: E(): 4.6e-55, 62.551% id in 243 aa, and to Bacillus halodurans hypothetical protein BH2242 TR:Q9KAP5 (EMBL:AP001514) (236 aa) fasta scores: E(): 9.8e-53, 59.664% id in 238 aa; radical activating enzyme complement(798108..798821) Staphylococcus aureus subsp. aureus MRSA252 2861422 YP_040191.1 CDS SAR0764 NC_002952.2 798825 799244 R Similar to Bacillus subtilis hypothetical protein YkvK TR:O31676 (EMBL:Z99111) (149 aa) fasta scores: E(): 5.9e-33, 60.284% id in 141 aa, and to Bacillus halodurans 6-pyruvoyl tetrahydrobiopterin synthase BH2243 TR:Q9KAP4 (EMBL:AP001514) (140 aa) fasta scores: E(): 1.2e-32, 58.394% id in 137 aa; 6-pyruvoyl-tetrahydropterin synthase complement(798825..799244) Staphylococcus aureus subsp. aureus MRSA252 2861423 YP_040192.1 CDS SAR0765 NC_002952.2 799246 799914 R Similar to Bacillus subtilis hypothetical protein YkvJ TR:O31675 (EMBL:Z99111) (219 aa) fasta scores: E(): 2.1e-62, 70.833% id in 216 aa, and to Bacillus halodurans aluminium resistance protein BH2244 TR:Q9KAP3 (EMBL:AP001514) (223 aa) fasta scores: E(): 5.1e-58, 68.545% id in 213 aa; hypothetical protein complement(799246..799914) Staphylococcus aureus subsp. aureus MRSA252 2860145 YP_040193.1 CDS SAR0766 NC_002952.2 800265 800858 D Similar to the N-terminal region of Pichia angusta anthranilate synthase component II SW:TRPG_PICAN (P09575) (367 aa) fasta scores: E(): 3.6e-30, 42.784% id in 194 aa, and to Acinetobacter calcoaceticus anthranilate synthase component II TrpG SW:TRPG_ACICA (P00902) (194 aa) fasta scores: E(): 5.4e-29, 44.503% id in 191 aa; glutamine amidotransferase class-I protein 800265..800858 Staphylococcus aureus subsp. aureus MRSA252 2860146 YP_040194.1 CDS SAR0767 NC_002952.2 800842 801993 D C-terminus is similar to the C-terminal region of Bacillus subtilis para-aminobenzoate synthase component I PabB SW:PABB_BACSU (P28820) (470 aa) fasta scores: E(): 1.2e-29, 39.216% id in 255 aa. Full length CDS is similar to the N-terminal region of Streptococcus pyogenes para-aminobenzoate synthetase PabB TR:Q99XW6 (EMBL:AE006622) (585 aa) fasta scores: E(): 3.1e-48, 43.626% id in 353 aa. Possible para-aminobenzoate synthetase pseudogene; para-aminobenzoate synthase component 800842..801993 Staphylococcus aureus subsp. aureus MRSA252 2861424 YP_040195.1 CDS SAR0768 NC_002952.2 801993 802601 D Similar to C-terminal region of Streptococcus pyogenes para-aminobenzoate synthetase PabB TR:Q99XW6 (EMBL:AE006622) (585 aa) fasta scores: E(): 3.8e-06, 26.667% id in 180 aa, and to Haemophilus influenzae hypothetical protein HI1169 SW:YB69_HAEIN (P44118) (188 aa) fasta scores: E(): 0.0013, 26.154% id in 195 aa. Possible para-aminobenzoate synthetase pseudogene; para-aminobenzoate synthetase component 801993..802601 Staphylococcus aureus subsp. aureus MRSA252 2861425 YP_040196.1 CDS SAR0769 NC_002952.2 802667 802873 D Poor database matches. Similar to N-terminus of Lactococcus lactis hypothetical protein YdbD TR:Q9CIP2 (EMBL:AE006268) (118 aa) fasta scores: E(): 2.4, 32.432% id in 74 aa; hypothetical protein 802667..802873 Staphylococcus aureus subsp. aureus MRSA252 2861426 YP_040197.1 CDS SAR0770 NC_002952.2 802961 803671 D Similar to Bacillus halodurans hypothetical protein BH1817 TR:Q9KBV7 (EMBL:AP001513) (225 aa) fasta scores: E(): 1.1e-22, 32.420% id in 219 aa, and to Pyrococcus abyssi hypothetical protein PAB1713 TR:Q9V006 (EMBL:AJ248286) (225 aa) fasta scores: E(): 2.4e-15, 30.088% id in 226 aa; hypothetical protein 802961..803671 Staphylococcus aureus subsp. aureus MRSA252 2861427 YP_040198.1 CDS SAR0771 NC_002952.2 803655 804659 D Similar to Bacillus halodurans hypothetical protein BH1818 TR:Q9KBV6 (EMBL:AP001513) (331 aa) fasta scores: E(): 5.3e-32, 34.783% id in 322 aa, and to Pseudomonas aeruginosa hypothetical protein PA0496 TR:Q9I622 (EMBL:AE004486) (325 aa) fasta scores: E(): 8.2e-15, 29.394% id in 330 aa; hypothetical protein 803655..804659 Staphylococcus aureus subsp. aureus MRSA252 2861428 YP_040199.1 CDS SAR0772 NC_002952.2 805133 807073 D Similar to Bacillus subtilis hypothetical protein YfnI TR:O06487 (EMBL:D86418) (653 aa) fasta scores: E(): 1.2e-132, 57.075% id in 636 aa, and to Lactococcus lactis hypothetical protein YibC TR:Q9CHC7 (EMBL:AE006314) (722 aa) fasta scores: E(): 3.3e-63, 37.705% id in 671 aa; sulfatase 805133..807073 Staphylococcus aureus subsp. aureus MRSA252 2861429 YP_040200.1 CDS SAR0773 NC_002952.2 807351 809228 D Similar to Bacillus subtilis hypothetical protein YfmR TR:O06476 (EMBL:D86418) (629 aa) fasta scores: E(): 4.2e-80, 43.879% id in 629 aa, and to Streptococcus pyogenes ABC transporter spy0867 TR:Q9A0A4 (EMBL:AE006536) (625 aa) fasta scores: E(): 2.7e-76, 44.608% id in 612 aa; ABC transporter ATP-binding protein 807351..809228 Staphylococcus aureus subsp. aureus MRSA252 2861430 YP_040201.1 CDS SAR0774 NC_002952.2 809240 811021 D Similar to Escherichia coli ATP-dependent DNA helicase RecQ SW:RECQ_ECOLI (P15043) (607 aa) fasta scores: E(): 8.3e-74, 37.186% id in 597 aa, and to Lactococcus lactis ATP-dependent DNA helicase RecQ TR:Q9CEM9 (EMBL:AE006411) (592 aa) fasta scores: E(): 8.5e-90, 44.370% id in 595 aa; ATP-dependent DNA helicase 809240..811021 Staphylococcus aureus subsp. aureus MRSA252 2860958 YP_040202.1 CDS SAR0775 NC_002952.2 811242 812219 D Similar to Bacillus subtilis choline transport ATP-binding protein ProV SW:OPBA_BACSU (Q45460) (381 aa) fasta scores: E(): 1.7e-40, 45.687% id in 313 aa, and to Lactococcus lactis choline ABC transporter ATP binding protein ChoQ TR:Q9CH91 (EMBL:AE006318) (305 aa) fasta scores: E(): 5.9e-41, 43.671% id in 316 aa; ABC transporter ATP-binding protein 811242..812219 Staphylococcus aureus subsp. aureus MRSA252 2860959 YP_040203.1 CDS SAR0776 NC_002952.2 812212 813726 D N-terminal region is similar to Bacillus subtilis choline ABC transporter permease ProW SW:OPBB_BACSU (Q45461) (217 aa) fasta scores: E(): 7.2e-30, 48.990% id in 198 aa. Full length CDS is similar to Streptococcus pyogenes ABC transporter SPY1134 TR:Q99ZQ2 (EMBL:AE006555) (510 aa) fasta scores: E(): 1.5e-91, 53.242% id in 509 aa; ABC transporter permease 812212..813726 Staphylococcus aureus subsp. aureus MRSA252 2860960 YP_040204.1 CDS SAR0777 NC_002952.2 813966 815024 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 813966..815024 Staphylococcus aureus subsp. aureus MRSA252 2860961 YP_040205.1 CDS SAR0778 NC_002952.2 815183 815725 D Similar to Homo sapiens mitochondrial 5'(3')-deoxyribonucleotidase DNT-2 TR:Q9NPB1 (EMBL:AJ277557) (228 aa) fasta scores: E(): 0.00049, 30.052% id in 193 aa, and to Similar to Bacillus subtilis hypothetical protein YorS TR:O31895 (EMBL:Z99114) (172 aa) fasta scores: E(): 5.6e-21, 39.306% id in 173 aa; hypothetical protein 815183..815725 Staphylococcus aureus subsp. aureus MRSA252 2860962 YP_040206.1 CDS SAR0779 NC_002952.2 815730 815864 D Poor database matches. Similar to C-terminal region of Streptococcus thermophilus hypothetical protein EpsB TR:O87929 (EMBL:AF053347) (243 aa) fasta scores: E(): 9.2, 35.135% id in 37 aa; hypothetical protein 815730..815864 Staphylococcus aureus subsp. aureus MRSA252 2860963 YP_040207.1 CDS SAR0780 NC_002952.2 816277 817194 R Similar to Bacillus subtilis multidrug transporter regulatory protein BmrU SW:BMRU_BACSU (P39074) (297 aa) fasta scores: E(): 3.5e-28, 31.757% id in 296 aa, and to Bacillus halodurans multidrug resistance protein BmrU TR:Q9KC00 (EMBL:AP001513) (311 aa) fasta scores: E(): 3.6e-21, 27.891% id in 294 aa; diacylglycerol kinase complement(816277..817194) Staphylococcus aureus subsp. aureus MRSA252 2860964 YP_040208.1 CDS SAR0781 NC_002952.2 817464 818969 R Similar to Lactococcus lactis di-/tripeptide transporter DtpT SW:DTPT_LACLA (P36574) (463 aa) fasta scores: E(): 1.3e-68, 39.355% id in 465 aa, and to Bacillus subtilis hypothetical protein YclF SW:YCLF_BACSU (P94408) (492 aa) fasta scores: E(): 8.9e-90, 48.780% id in 492 aa. CDS is extended at the N-terminus in comparison to the Lactococcus lactis protein. Possible alternative translational start site; proton-dependent oligopeptide transport protein complement(817464..818969) Staphylococcus aureus subsp. aureus MRSA252 2860965 YP_040209.1 CDS SAR0782 NC_002952.2 819309 819809 R NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase complement(819309..819809) Staphylococcus aureus subsp. aureus MRSA252 2860966 YP_040210.1 CDS SAR0783 NC_002952.2 819829 820695 R Similar to Treponema pallidum conserved hypothetical integral membrane protein TP0986 TR:O83951 (EMBL:AE001266) (294 aa) fasta scores: E(): 1.5e-32, 37.979% id in 287 aa, and to Pseudomonas aeruginosa hypothetical protein PA4834 TR:Q9HUX6 (EMBL:AE004896) (284 aa) fasta scores: E(): 1e-20, 31.481% id in 270 aa; hypothetical protein complement(819829..820695) Staphylococcus aureus subsp. aureus MRSA252 2860967 YP_040211.1 CDS nrdI NC_002952.2 821497 821895 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 821497..821895 Staphylococcus aureus subsp. aureus MRSA252 2860968 YP_040212.1 CDS rir1 NC_002952.2 821858 823963 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 821858..823963 Staphylococcus aureus subsp. aureus MRSA252 2859272 YP_040213.1 CDS nrdF NC_002952.2 824083 825054 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 824083..825054 Staphylococcus aureus subsp. aureus MRSA252 2859273 YP_040214.1 CDS sstA NC_002952.2 825431 826402 D Similar to Vibrio anguillarum ferric anguibactin ABC transporter permease FatD SW:FATD_VIBAN (P37738) (314 aa) fasta scores: E(): 4.6e-40, 35.599% id in 309 aa. Previously sequenced as Staphylococcus aureus iron transport membrane protein SstA TR:O87825 (EMBL:AJ005352) (323 aa) fasta scores: E(): 1.6e-104, 97.214% id in 323 aa; FecCD transport family protein 825431..826402 Staphylococcus aureus subsp. aureus MRSA252 2859509 YP_040215.1 CDS sstB NC_002952.2 826389 827345 D Similar to Vibrio anguillarum ferric anguibactin ABC transporter permease FatC SW:FATC_VIBAN (P37737) (317 aa) fasta scores: E(): 9.6e-26, 28.797% id in 316 aa, and to Staphylococcus aureus iron transport membrane protein SstB TR:O87826 (EMBL:AJ005352) (226 aa) fasta scores: E(): 1.1e-70, 99.107% id in 224 aa; FecCD transport family protein 826389..827345 Staphylococcus aureus subsp. aureus MRSA252 2859510 YP_040216.1 CDS sstC NC_002952.2 827342 828103 D Similar to Escherichia coli citrate-dependent iron(III) transport system, ATP-binding protein FecE SW:FECE_ECOLI (P15031) (255 aa) fasta scores: E(): 2.5e-24, 37.903% id in 248 aa, and to Staphylococcus aureus iron transport ATP-binding protein SstC TR:O87827 (EMBL:AJ005352) (253 aa) fasta scores: E(): 1.9e-78, 96.047% id in 253 aa; ABC transporter ATP-binding protein 827342..828103 Staphylococcus aureus subsp. aureus MRSA252 2859511 YP_040217.1 CDS sstD NC_002952.2 828218 829246 D Similar to Vibrio anguillarum ferric anguibactin-binding protein precursor FatB SW:FATB_VIBAN (P11460) (322 aa) fasta scores: E(): 9.7e-18, 30.45% id in 266 aa, and to Staphylococcus aureus iron transporter lipoprotein SstD TR:O87828 (EMBL:AJ005352) (342 aa) fasta scores: E(): 2.2e-110, 97.07% id in 342 aa; lipoprotein 828218..829246 Staphylococcus aureus subsp. aureus MRSA252 2859512 YP_040218.1 CDS SAR0791 NC_002952.2 829563 829877 R Similar to Saccharomyces cerevisiae hypothetical protein YKl084W SW:YKI4_YEAST (P36078) (116 aa) fasta scores: E(): 1.2e-19, 45.192% id in 104 aa, and to Schizosaccharomyces pombe hypothetical protein SPAC29B12.12 TR:O14033 (EMBL:Z99164) (113 aa) fasta scores: E(): 6.7e-17, 41.000% id in 100 aa; hypothetical protein complement(829563..829877) Staphylococcus aureus subsp. aureus MRSA252 2860969 YP_040219.1 CDS murB NC_002952.2 829895 830818 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(829895..830818) Staphylococcus aureus subsp. aureus MRSA252 2861320 YP_040220.1 CDS SAR0793 NC_002952.2 830945 831463 R Poor database matches. C-terminus is similar to the C-terminal region of Bacillus firmus glutamate-rich protein GrpB SW:GRPB_BACFI (Q45133) (174 aa) fasta scores: E(): 2.3e-06, 25.517% id in 145 aa; hypothetical protein complement(830945..831463) Staphylococcus aureus subsp. aureus MRSA252 2860970 YP_040221.1 CDS SAR0794 NC_002952.2 831583 832461 D N-terminal region is similar to Borrelia burgdorferi lipoprotein Bbk2.11 TR:Q44739 (EMBL:U30617) (233 aa) fasta scores: E(): 0.15, 21.702% id in 235 aa. Full length CDS is similar to N-terminal region of Ureaplasma parvum hypothetical lipoprotein UU125 TR:Q9PR19 (EMBL:AE002113) (394 aa) fasta scores: E(): 0.18, 25.085% id in 295 aa; hypothetical protein 831583..832461 Staphylococcus aureus subsp. aureus MRSA252 2860971 YP_040222.1 CDS SAR0795 NC_002952.2 832615 832935 D Similar to Bacillus subtilis hypothetical protein YtxJ SW:YTXJ_BACSU (P39914) (108 aa) fasta scores: E(): 4.3e-12, 43.564% id in 101 aa, and to Bacillus halodurans general stress protein BH3013 TR:Q9K8J3 (EMBL:AP001517) (112 aa) fasta scores: E(): 1.2e-09, 36.792% id in 106 aa; hypothetical protein 832615..832935 Staphylococcus aureus subsp. aureus MRSA252 2860972 YP_040223.1 CDS SAR0796 NC_002952.2 833360 834484 D Similar to Escherichia coli glycerate kinase 1 GlxK SW:GRK1_ECOLI (P77364) (381 aa) fasta scores: E(): 7.1e-18, 23.699% id in 346 aa, and to Bacillus halodurans glycerate kinase GlxK SW:GRK_BACHD (Q9Z9P2) (380 aa) fasta scores: E(): 2.9e-21, 25.656% id in 343 aa; glycerate kinase 833360..834484 Staphylococcus aureus subsp. aureus MRSA252 2860973 YP_040224.1 CDS pepT NC_002952.2 834672 835898 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(834672..835898) Staphylococcus aureus subsp. aureus MRSA252 2859895 YP_040225.1 CDS SAR0798 NC_002952.2 835912 836406 R Similar to Bacillus halodurans hypothetical protein BH0082 TR:Q9KGH9 (EMBL:AP001507) (150 aa) fasta scores: E(): 7.4e-12, 37.500% id in 136 aa, and to Pasteurella multocida hypothetical protein PM1894 TR:Q9CJU7 (EMBL:AE006227) (153 aa) fasta scores: E(): 5.8e-07, 29.655% id in 145 aa; hypothetical protein complement(835912..836406) Staphylococcus aureus subsp. aureus MRSA252 2860974 YP_040226.1 CDS SAR0799 NC_002952.2 836424 837185 R Similar to Bacillus halodurans hypothetical protein BH0081 TR:Q9KGI0 (EMBL:AP001507) (251 aa) fasta scores: E(): 1.9e-30, 36.800% id in 250 aa, and to Campylobacter jejuni integral membrane protein CJ1166C TR:Q9PNC9 (EMBL:AL139077) (258 aa) fasta scores: E(): 1.5e-08, 22.619% id in 252 aa; hypothetical protein complement(836424..837185) Staphylococcus aureus subsp. aureus MRSA252 2860975 YP_040227.1 CDS SAR0800 NC_002952.2 837381 838451 R Similar to Bacillus subtilis hypothetical protein YhcK SW:YHCK_BACSU (P54595) (359 aa) fasta scores: E(): 1.8e-19, 27.901% id in 362 aa, and to Deinococcus radiodurans GGDEF family protein DR1090 TR:Q9RVD9 (EMBL:AE001959) (356 aa) fasta scores: E(): 1.7e-13, 26.158% id in 367 aa; hypothetical protein complement(837381..838451) Staphylococcus aureus subsp. aureus MRSA252 2860976 YP_040228.1 CDS SAR0801 NC_002952.2 838769 839824 D Previously sequenced as Staphylococcus aureus lipophilic protein that affects bacterial lysis and methicillin resistance levels Llm TR:Q53761 (EMBL:D21131) (351 aa) fasta scores: E(): 4.5e-118, 99.715% id in 351 aa. Similar to Escherichia coli UDP-phosphate alpha-N-acetylglucosaminyltransferase Rfe SW:RFE_ECOLI (P24235) (367 aa) fasta scores: E(): 5e-19, 26.647% id in 334 aa; glycosyl transferase 838769..839824 Staphylococcus aureus subsp. aureus MRSA252 2860977 YP_040229.1 CDS SAR0802 NC_002952.2 839988 840629 R Similar to Bacillus halodurans hypothetical protein BH3630 TR:Q9K6U5 (EMBL:AP001519) (213 aa) fasta scores: E(): 2.7e-32, 45.972% id in 211 aa, and to Bacillus subtilis hypothetical protein YvhK SW:YVYE_BACSU (P32437) (217 aa) fasta scores: E(): 2.2e-31, 48.000% id in 200 aa; hypothetical protein complement(839988..840629) Staphylococcus aureus subsp. aureus MRSA252 2859188 YP_040230.1 CDS SAR0803 NC_002952.2 840773 841639 D Similar to Bacillus halodurans hypothetical protein BH3627 TR:Q9K6U8 (EMBL:AP001519) (283 aa) fasta scores: E(): 3e-35, 38.869% id in 283 aa, and to Bacillus subtilis hypothetical protein DegV SW:DEGV_BACSU (P32436) (281 aa) fasta scores: E(): 4.9e-33, 37.276% id in 279 aa; hypothetical protein 840773..841639 Staphylococcus aureus subsp. aureus MRSA252 2859372 YP_040231.1 CDS SAR0804 NC_002952.2 842003 843085 D Similar to the C-terminal regions of Bacillus halodurans late competence protein ComFA TR:Q9K6U9 (EMBL:AP001519) (441 aa) fasta scores: E(): 5.6e-33, 34.835% id in 333 aa, and to Bacillus subtilis comF operon protein 1 ComFA SW:CMF1_BACSU (P39145) (463 aa) fasta scores: E(): 2.4e-31, 37.808% id in 365 aa. Similarity to the N-terminal region of the Bacillus subtilis comF operon protein 1 upstream of the predicted translational start. No alternative upstream translational start site. Possible truncated protein; helicase 842003..843085 Staphylococcus aureus subsp. aureus MRSA252 2860718 YP_040232.1 CDS SAR0805 NC_002952.2 843078 843752 D Similar to Bacillus subtilis comF operon protein 3 ComFC SW:CMF3_BACSU (P39147) (229 aa) fasta scores: E(): 4e-09, 27.966% id in 236 aa, and to Lactococcus lactis competence protein ComFC TR:Q9CGK7 (EMBL:AE006341) (216 aa) fasta scores: E(): 7.3e-14, 33.624% id in 229 aa; hypothetical protein 843078..843752 Staphylococcus aureus subsp. aureus MRSA252 2860719 YP_040233.1 CDS SAR0806 NC_002952.2 843813 844385 D Similar to Spinacia oleracea plastid-specific 30S ribosomal protein 1 S22 SW:RR30_SPIOL (P19954) (302 aa) fasta scores: E(): 2.2e-05, 29.064% id in 203 aa, and to Lactococcus lactis hypothetical protein TR:Q9L474 (EMBL:AJ249134) (185 aa) fasta scores: E(): 2.6e-34, 53.191% id in 188 aa; S30EA family ribosomal protein 843813..844385 Staphylococcus aureus subsp. aureus MRSA252 2860720 YP_040234.1 CDS secA NC_002952.2 844799 847330 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 844799..847330 Staphylococcus aureus subsp. aureus MRSA252 2859133 YP_040235.1 CDS prfB NC_002952.2 847645 848755 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 join(847645..847716,847718..848755) Staphylococcus aureus subsp. aureus MRSA252 2860149 YP_040236.1 CDS SAR0809 NC_002952.2 849524 850363 D Poor database matches. C-terminal region is similar to C-terminus of Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 6.6e-16, 49.624% id in 133 aa. Full length CDS is similar to the C-terminus of Streptococcus agalactiae cell wall separation protein PcsB TR:Q9AKA4 (EMBL:AJ277292) (447 aa) fasta scores: E(): 4.8e-09, 30.515% id in 272 aa; hypothetical protein 849524..850363 Staphylococcus aureus subsp. aureus MRSA252 2860721 YP_040237.1 CDS SAR0810 NC_002952.2 850537 851187 D Similar to Escherichia coli hypothetical protein B2291 TR:P76491 (EMBL:AE000318) (199 aa) fasta scores: E(): 1.2e-06, 24.468% id in 188 aa, and to Vibrio cholerae hypothetical protein VC1978 TR:Q9KQM0 (EMBL:AE004273) (233 aa) fasta scores: E(): 2.7e-06, 25.532% id in 188 aa; phosphohydrolase 850537..851187 Staphylococcus aureus subsp. aureus MRSA252 2860722 YP_040238.1 CDS SAR0811 NC_002952.2 851184 851420 D Poor database matches. Similar to Bacillus subtilis membrane protein CsbA SW:CSBA_BACSU (P37953) (76 aa) fasta scores: E(): 0.00017, 40.580% id in 69 aa; hypothetical protein 851184..851420 Staphylococcus aureus subsp. aureus MRSA252 2860723 YP_040239.1 CDS uvrB NC_002952.2 851683 853674 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 851683..853674 Staphylococcus aureus subsp. aureus MRSA252 2860424 YP_040240.1 CDS uvrA NC_002952.2 853682 856528 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 853682..856528 Staphylococcus aureus subsp. aureus MRSA252 2860423 YP_040241.1 CDS hprK NC_002952.2 857139 858071 D catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 857139..858071 Staphylococcus aureus subsp. aureus MRSA252 2859645 YP_040242.1 CDS lgt NC_002952.2 858077 858919 D transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 858077..858919 Staphylococcus aureus subsp. aureus MRSA252 2859802 YP_040243.1 CDS SAR0816 NC_002952.2 858927 859412 D Similar to Escherichia coli maltose O-acetyltransferase Maa SW:MAA_ECOLI (P77791) (182 aa) fasta scores: E(): 6e-09, 35.185% id in 162 aa, and to Staphylococcus xylosus acetyltransferase YvoF TR:Q9S1H3 (EMBL:AJ243915) (158 aa) fasta scores: E(): 3.8e-34, 59.236% id in 157 aa; acetyltransferase 858927..859412 Staphylococcus aureus subsp. aureus MRSA252 2860724 YP_040244.1 CDS SAR0817 NC_002952.2 859420 860859 D Similar to Staphylococcus xylosus hypothetical protein YvcD TR:Q9S1H2 (EMBL:AJ243915) (478 aa) fasta scores: E(): 6.8e-124, 62.213% id in 479 aa, and to Bacillus subtilis hypothetical protein YvcD TR:O06968 (EMBL:Z94043) (484 aa) fasta scores: E(): 1.7e-13, 21.224% id in 490 aa; hypothetical protein 859420..860859 Staphylococcus aureus subsp. aureus MRSA252 2860725 YP_040245.1 CDS trxB NC_002952.2 860926 861861 D Similar to Streptomyces clavuligerus thioredoxin reductase TrxB SW:TRXB_STRCL (Q05741) (321 aa) fasta scores: E(): 1.7e-44, 45.928% id in 307 aa, and to Bacillus subtilis thioredoxin reductase TrxB SW:TRXB_BACSU (P80880) (315 aa) fasta scores: E(): 9.7e-81, 72.368% id in 304 aa; thioredoxin reductase 860926..861861 Staphylococcus aureus subsp. aureus MRSA252 2860406 YP_040246.1 CDS SAR0820 NC_002952.2 862629 863540 D Similar to Bacillus subtilis hypothetical protein YvcJ SW:YVCJ_BACSU (O06973) (295 aa) fasta scores: E(): 2.5e-58, 52.862% id in 297 aa, and to Bacillus halodurans hypothetical protein BH3569 TR:Q9K705 (EMBL:AP001519) (295 aa) fasta scores: E(): 8.9e-56, 51.678% id in 298 aa; hypothetical protein 862629..863540 Staphylococcus aureus subsp. aureus MRSA252 2860726 YP_040247.1 CDS SAR0821 NC_002952.2 863537 864532 D Similar to Bacillus halodurans hypothetical protein BH3568 TR:Q9K706 (EMBL:AP001519) (322 aa) fasta scores: E(): 9.1e-56, 50.955% id in 314 aa, and to Bacillus subtilis hypothetical protein YvcK SW:YVCK_BACSU (O06974) (317 aa) fasta scores: E(): 5.3e-55, 47.771% id in 314 aa; hypothetical protein 863537..864532 Staphylococcus aureus subsp. aureus MRSA252 2860727 YP_040248.1 CDS SAR0822 NC_002952.2 864641 865585 D Similar to Bacillus subtilis hypothetical protein YvcL TR:O06975 (EMBL:Z94043) (316 aa) fasta scores: E(): 1.2e-68, 62.222% id in 315 aa, and to Bacillus halodurans hypothetical protein BH3567 protein bh3567 TR:Q9K707 (EMBL:AP001519) (320 aa) fasta scores: E(): 3.5e-67, 62.540% id in 315 aa; hypothetical protein 864641..865585 Staphylococcus aureus subsp. aureus MRSA252 2860728 YP_040249.1 CDS clpP NC_002952.2 866154 866741 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 866154..866741 Staphylococcus aureus subsp. aureus MRSA252 2859236 YP_040250.1 CDS SAR0824 NC_002952.2 866923 868557 D malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 866923..868557 Staphylococcus aureus subsp. aureus MRSA252 2860729 YP_040251.1 CDS SAR0825 NC_002952.2 868764 869666 R Similar to Bacillus subtilis hypothetical protein YfhF SW:YFHF_BACSU (O31574) (303 aa) fasta scores: E(): 1.4e-43, 40.878% id in 296 aa, and to Pseudomonas aeruginosa hypothetical protein PA4656 TR:Q9HVD6 (EMBL:AE004879) (305 aa) fasta scores: E(): 1e-35, 36.700% id in 297 aa; hypothetical protein complement(868764..869666) Staphylococcus aureus subsp. aureus MRSA252 2860730 YP_040252.1 CDS SAR0826 NC_002952.2 870369 870998 D No significant database matches. CDS is Lys and Gln rich (17.7% and 15.3% of total amino acid content, respectively). Contains coiled-coiled domain, residues 58 to 87; hypothetical protein 870369..870998 Staphylococcus aureus subsp. aureus MRSA252 2860731 YP_040253.1 CDS gapR NC_002952.2 871492 872505 D Previously sequenced as Staphylococcus aureus glycolytic operon regulator GapR TR:Q9Z5C6 (EMBL:AJ133520) (337 aa) fasta scores: E(): 2.8e-118, 99.407% id in 337 aa. Similar to Bacillus megaterium central glycolytic genes regulator CggR SW:CGGR_BACME (P35168) (342 aa) fasta scores: E(): 6.4e-52, 47.024% id in 336 aa; glycolytic operon regulator 871492..872505 Staphylococcus aureus subsp. aureus MRSA252 2860690 YP_040254.1 CDS gap1 NC_002952.2 872558 873568 D Similar to Streptococcus pyogenes glyceraldehyde 3-phosphate dehydrogenase, and human plasmin receptor, Plr SW:G3P_STRPY (P50467) (335 aa) fasta scores: E(): 4.4e-83, 68.060% id in 335 aa. Previously sequenced as Staphylococcus aureus glyceraldehyde-3-phosphate dehydrogenase Gap TR:Q9Z5C5 (EMBL:AJ133520) (336 aa) fasta scores: E(): 2.7e-122, 100.000% id in 336 aa; glyceraldehyde 3-phosphate dehydrogenase 1 872558..873568 Staphylococcus aureus subsp. aureus MRSA252 2860688 YP_040255.1 CDS pgk NC_002952.2 873707 874897 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 873707..874897 Staphylococcus aureus subsp. aureus MRSA252 2859899 YP_040256.1 CDS tpiA NC_002952.2 875019 875780 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 875019..875780 Staphylococcus aureus subsp. aureus MRSA252 2860394 YP_040257.1 CDS pgm NC_002952.2 875783 877300 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 875783..877300 Staphylococcus aureus subsp. aureus MRSA252 2859900 YP_040258.1 CDS eno NC_002952.2 877430 878734 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 877430..878734 Staphylococcus aureus subsp. aureus MRSA252 2859612 YP_040259.1 CDS SAR0833 NC_002952.2 879071 879529 D Poor database matches. Similar to an internal region of Helicobacter pylori J99 hypothetical protein JHP0324 TR:Q9ZM98 (EMBL:AE001468) (220 aa) fasta scores: E(): 0.72, 25.874% id in 143 aa; hypothetical protein 879071..879529 Staphylococcus aureus subsp. aureus MRSA252 2860862 YP_040260.1 CDS secG NC_002952.2 879596 879829 D Similar to Escherichia coli protein-export membrane protein SecG SW:SECG_ECOLI (P33582) (110 aa) fasta scores: E(): 0.0082, 31.507% id in 73 aa, and to Bacillus subtilis probable protein-export membrane protein SecG SW:SECG_BACSU (O32233) (76 aa) fasta scores: E(): 1.1e-15, 66.667% id in 75 aa; preprotein translocase subunit SecG 879596..879829 Staphylococcus aureus subsp. aureus MRSA252 2859136 YP_040261.1 CDS est NC_002952.2 879958 880698 D Similar to Bacillus stearothermophilus carboxylesterase precursor Est SW:EST_BACST (Q06174) (247 aa) fasta scores: E(): 3.1e-53, 58.130% id in 246 aa, and to Bacillus halodurans carboxylesterase BH3554 TR:Q9K719 (EMBL:AP001519) (248 aa) fasta scores: E(): 6.8e-51, 56.048% id in 248 aa; carboxylesterase 879958..880698 Staphylococcus aureus subsp. aureus MRSA252 2859616 YP_040262.1 CDS rnr NC_002952.2 880732 883104 D Similar to Escherichia coli ribonuclease R Rnr SW:RNR_ECOLI (P21499) (813 aa) fasta scores: E(): 1.9e-79, 34.875% id in 800 aa, and to Bacillus subtilis ribonuclease R Rnr SW:RNR_BACSU (O32231) (779 aa) fasta scores: E(): 9.8e-148, 53.169% id in 773 aa. Rnr is required for expression of virulence in Shigella and enteroinvasive Escherichia coli; ribonuclease R 880732..883104 Staphylococcus aureus subsp. aureus MRSA252 2859279 YP_040263.1 CDS smpB NC_002952.2 883126 883590 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 883126..883590 Staphylococcus aureus subsp. aureus MRSA252 2859149 YP_040264.1 CDS SAR0838 NC_002952.2 884556 885170 D Poor database matches. Similar to Lactococcus lactis plasmid pCD4 hypothetical protein Orf1 TR:Q9AC96 (EMBL:AF306799) (193 aa) fasta scores: E(): 3.3e-09, 27.895% id in 190 aa, and to Methanococcus jannaschii hypothetical protein MJ0793 SW:Y793_METJA (Q58203) (178 aa) fasta scores: E(): 0.014, 26.203% id in 187 aa; hypothetical protein 884556..885170 Staphylococcus aureus subsp. aureus MRSA252 2860863 YP_040265.1 CDS SAR0839 NC_002952.2 885458 886186 R Poor database matches. N-terminus is similar to N-terminal region of Bacillus subtilis lipoprotein YjhA TR:O34725 (EMBL:AF015825) (213 aa) fasta scores: E(): 0.55, 32.639% id in 144 aa. CDS contains a C-terminal hydrophilic domain; hypothetical protein complement(885458..886186) Staphylococcus aureus subsp. aureus MRSA252 2860864 YP_040266.1 CDS SAR0840 NC_002952.2 886785 887306 D No significant database matches to the full length CDS. N-terminus is similar to N-terminal region of Helicobacter pylori J99 hypothetical protein JHP0535 TR:Q9ZLP3 (EMBL:AE001486) (329 aa) fasta scores: E(): 6.2, 25.926% id in 135 aa; hypothetical protein 886785..887306 Staphylococcus aureus subsp. aureus MRSA252 2860865 YP_040267.1 CDS SAR0841 NC_002952.2 887445 887975 D Similar to Lactococcus lactis hypothetical protein YafC TR:Q9CJE1 (EMBL:AE006244) (173 aa) fasta scores: E(): 7.7e-27, 47.399% id in 173 aa, and to Pseudomonas aeruginosa hypothetical protein PA0711 TR:Q9I5L7 (EMBL:AE004506) (168 aa) fasta scores: E(): 1e-07, 31.250% id in 176 aa; acetyltransferase 887445..887975 Staphylococcus aureus subsp. aureus MRSA252 2860866 YP_040268.1 CDS clfA NC_002952.2 888239 891328 D Previously sequenced as Staphylococcus aureus clumping factor ClfA TR:Q53653 (EMBL:Z18852) (933 aa) fasta scores: E(): 2.3e-215, 86.297% id in 1029 aa. Similar to the C-terminal region of Staphylococcus epidermidis cell-surface adhesin SdrF TR:Q9KI14 (EMBL:AF245041) (1733 aa) fasta scores: E(): 1.5e-94, 46.230% id in 1008 aa. Contains an inperfect dipetide repeat (SD x181), residues 599 to 960. CDS contains extra copies of the dipeptide repeat compared to the previously sequenced clumping factor ClfA. Probable LPXTG-sorted surface protein; clumping factor 888239..891328 Staphylococcus aureus subsp. aureus MRSA252 2859231 YP_040269.1 CDS SAR0845 NC_002952.2 893407 894432 D Poor database matches. Similar to Staphylococcus aureus extracellular matrix and plasma binding protein precursor Ssp TR:Q9L3L5 (EMBL:AJ272084) (340 aa) fasta scores: E(): 1.6e-106, 86.550% id in 342 aa; hypothetical protein 893407..894432 Staphylococcus aureus subsp. aureus MRSA252 2860868 YP_040270.1 CDS SAR0846 NC_002952.2 894763 895320 D Poor database matches. Similar to C-terminal region of Staphylococcus aureus secreted von Willebrand factor-binding protein precursor Vwb TR:AAK52333 (EMBL:AY032850) (508 aa) fasta scores: E(): 6e-15, 38.889% id in 162 aa. N-terminus is similar to the N-terminal region of Staphylococcus aureus extracellular matrix and plasma binding protein precursor Ssp TR:Q9K2Q1 (EMBL:AJ272083) (340 aa) fasta scores: E(): 1.2, 36.000% id in 100 aa; hypothetical protein 894763..895320 Staphylococcus aureus subsp. aureus MRSA252 2860869 YP_040271.1 CDS nuc NC_002952.2 895661 896347 D Similar to Staphylococcus aureus thermonuclease precursor Nuc SW:NUC_STAAU (P00644) (231 aa) fasta scores: E(): 4.9e-80, 98.246% id in 228 aa. C-terminal region is similar to Bacillus subtilis hypothetical protein YncB TR:P94492 (EMBL:U66480) (211 aa) fasta scores: E(): 1e-22, 45.745% id in 188 aa; thermonuclease precursor 895661..896347 Staphylococcus aureus subsp. aureus MRSA252 2859168 YP_040272.1 CDS cspC NC_002952.2 896704 896904 D Similar to Bacillus cereus cold shock-like protein CspC SW:CSPC_BACCE (Q45098) (65 aa) fasta scores: E(): 3.2e-20, 85.714% id in 63 aa, and to Bacillus subtilis cold shock protein CspC SW:CSPC_BACSU (P39158) (66 aa) fasta scores: E(): 2.8e-18, 76.923% id in 65 aa. Similar to SAR1414, 80.303% identity (80.303% ungapped) in 66 aa overlap, and to SAR2790, 80.952% identity (80.952% ungapped) in 63 aa overlap; cold shock protein 896704..896904 Staphylococcus aureus subsp. aureus MRSA252 2859249 YP_040273.1 CDS SAR0849 NC_002952.2 897401 897619 R hypothetical protein complement(897401..897619) Staphylococcus aureus subsp. aureus MRSA252 2860870 YP_040274.1 CDS SAR0850 NC_002952.2 897681 897965 R Poor database matches. Similar to N-terminal region of Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf121 TR:Q9B0H0 (EMBL:AB045978) (121 aa) fasta scores: E(): 3.6e-06, 32.258% id in 93 aa; hypothetical protein complement(897681..897965) Staphylococcus aureus subsp. aureus MRSA252 2860871 YP_040275.1 CDS SAR0851 NC_002952.2 898053 898622 R Poor database matches. N-terminus is similar to N-terminal region of Bacillus thuringiensis hypothetical protein SW:YGI2_BACTU (P10023) (270 aa) fasta scores: E(): 9.1e-11, 33.125% id in 160 aa; hypothetical protein complement(898053..898622) Staphylococcus aureus subsp. aureus MRSA252 2860872 YP_040276.1 CDS SAR0852 NC_002952.2 898810 898998 R Poor database matches. Similar to an internal region of Corynebacterium glutamicum lincomycin resistance protein LmrB TR:Q9L6D2 (EMBL:AF237667) (481 aa) fasta scores: E(): 1.7, 38.095% id in 63 aa. Doubtful CDS; hypothetical protein complement(898810..898998) Staphylococcus aureus subsp. aureus MRSA252 2860873 YP_040277.1 CDS SAR0853 NC_002952.2 899027 899287 R Poor database matches. Weakly similar to Sulfolobus solfataricus hypothetical protein SSO0816 TR:Q9UXK1 (EMBL:Y18930) (110 aa) fasta scores: E(): 2, 24.138% id in 87 aa; hypothetical protein complement(899027..899287) Staphylococcus aureus subsp. aureus MRSA252 2860874 YP_040278.1 CDS SAR0854 NC_002952.2 899628 899831 D Poor database matches. N-terminus is similar to N-terminal region of Streptococcus pyogenes hypothetical protein SPY0467 TR:Q9A148 (EMBL:AE006506) (71 aa) fasta scores: E(): 3.7, 33.333% id in 45 aa; hypothetical protein 899628..899831 Staphylococcus aureus subsp. aureus MRSA252 2860875 YP_040279.1 CDS SAR0855 NC_002952.2 899828 900064 R hypothetical protein complement(899828..900064) Staphylococcus aureus subsp. aureus MRSA252 2860876 YP_040280.1 CDS SAR0856 NC_002952.2 900289 900870 D Similar to an internal region of Salmonella typhimurium alpha-ribazole-5'-phosphate phosphatase CobC SW:COBC_SALTY (P39701) (234 aa) fasta scores: E(): 0.00019, 28.402% id in 169 aa, and to Thermotoga maritima phosphoglycerate mutase TM1374 TR:Q9X194 (EMBL:AE001791) (201 aa) fasta scores: E(): 3e-07, 29.949% id in 197 aa; phosphoglycerate mutase 900289..900870 Staphylococcus aureus subsp. aureus MRSA252 2860877 YP_040281.1 CDS SAR0857 NC_002952.2 900943 901560 R Similar to Bacillus halodurans hypothetical protein BH0431 TR:Q9KFP7 (EMBL:AP001508) (200 aa) fasta scores: E(): 1.7e-29, 43.939% id in 198 aa, and to Escherichia coli hypothetical protein YggA SW:YGGA_ECOLI (P11667) (211 aa) fasta scores: E(): 2.3e-13, 32.394% id in 213 aa. Similar to SAR2591, 63.415% identity (63.415% ungapped) in 205 aa overlap; LysE type translocator protein complement(900943..901560) Staphylococcus aureus subsp. aureus MRSA252 2860878 YP_040282.1 CDS SAR0858 NC_002952.2 901716 902210 R Poor database matches. Similar to bacteriophage bIL311 hypothetical protein Orf17 TR:Q9AZG4 (EMBL:AF323672) (168 aa) fasta scores: E(): 9.2e-06, 26.380% id in 163 aa; hypothetical protein complement(901716..902210) Staphylococcus aureus subsp. aureus MRSA252 2860879 YP_040284.1 CDS SAR0859 NC_002952.2 902609 903031 R Similar to Xanthomonas campestris organic hydroperoxide resistance protein Ohr SW:OHR_XANCH (O68390) (142 aa) fasta scores: E(): 1e-11, 35.507% id in 138 aa, and to Bacillus subtilis general stress protein YkzA SW:G17O_BACSU (P80242) (135 aa) fasta scores: E(): 2.3e-17, 43.284% id in 134 aa; OsmC-like protein complement(902609..903031) Staphylococcus aureus subsp. aureus MRSA252 2860880 YP_040285.1 CDS SAR0860 NC_002952.2 903179 903895 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 903179..903895 Staphylococcus aureus subsp. aureus MRSA252 2860881 YP_040286.1 CDS SAR0861 NC_002952.2 903978 904517 D Similar to Bacillus halodurans hypothetical protein BH0303 TR:Q9KG12 (EMBL:AP001508) (184 aa) fasta scores: E(): 2.6e-18, 34.637% id in 179 aa, and to Bacillus subtilis hypothetical protein YfhC TR:O31571 (EMBL:Z99108) (194 aa) fasta scores: E(): 2.7e-14, 31.034% id in 174 aa; nitroreductase 903978..904517 Staphylococcus aureus subsp. aureus MRSA252 2860882 YP_040287.1 CDS SAR0862 NC_002952.2 904667 904987 R Similar to Saccharomyces cerevisiae thioredoxin II TRX2 SW:TRX2_YEAST (P22217) (102 aa) fasta scores: E(): 4.2e-09, 39.130% id in 92 aa, and to Bacillus subtilis probable thioredoxin YdbP TR:P96611 (EMBL:AB001488) (106 aa) fasta scores: E(): 9.9e-23, 57.282% id in 103 aa; thioredoxin complement(904667..904987) Staphylococcus aureus subsp. aureus MRSA252 2860883 YP_040288.1 CDS SAR0863 NC_002952.2 905131 905487 D Similar to Bacillus halodurans arsenate reductase BH3485 TR:Q9K785 (EMBL:AP001518) (119 aa) fasta scores: E(): 2.1e-21, 51.304% id in 115 aa, and to Bacillus subtilis hypothetical protein YusI SW:YUSI_BACSU (O32175) (118 aa) fasta scores: E(): 2.4e-21, 51.304% id in 115 aa; hypothetical protein 905131..905487 Staphylococcus aureus subsp. aureus MRSA252 2860884 YP_040289.1 CDS gcvH NC_002952.2 905645 906025 D part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 905645..906025 Staphylococcus aureus subsp. aureus MRSA252 2860695 YP_040290.1 CDS SAR0865 NC_002952.2 906203 907081 D C-terminus is similar to C-terminal regions of Bacillus subtilis hypothetical protein YwqG TR:P96719 (EMBL:Z92952) (261 aa) fasta scores: E(): 4.1e-07, 31.405% id in 242 aa, and Clostridium acetobutylicum hypothetical protein CAC0820 TR:AAK78796 (EMBL:AE007597) (249 aa) fasta scores: E(): 0.00095, 30.769% id in 247 aa; hypothetical protein 906203..907081 Staphylococcus aureus subsp. aureus MRSA252 2860885 YP_040291.1 CDS SAR0867 NC_002952.2 907672 908058 D Poor database matches. Similar to Bacillus subtilis hypothetical protein YusF TR:O32172 (EMBL:Z99120) (146 aa) fasta scores: E(): 2.4e-14, 42.574% id in 101 aa, and to Vibrio cholerae toxin-coregulated pilus biosynthesis protein H TcpH TR:Q9AGW7 (EMBL:AF325734) (136 aa) fasta scores: E(): 3.4, 25.253% id in 99 aa. CDS is truncated at the N-terminus in comparison to the Bacillus subtilis protein; hypothetical protein 907672..908058 Staphylococcus aureus subsp. aureus MRSA252 2860886 YP_040292.1 CDS SAR0868 NC_002952.2 908051 908347 D Similar to Mycobacterium tuberculosis thioredoxin TrxA SW:THIO_MYCTU (P52229) (115 aa) fasta scores: E(): 0.029, 30.556% id in 72 aa, and to Bacillus subtilis hypothetical protein YusE TR:O32171 (EMBL:Z99120) (106 aa) fasta scores: E(): 2.1e-08, 41.176% id in 85 aa. Lack of similarity at the N-terminus in comparison to Mycobacterium tuberculosis thioredoxin; hypothetical protein 908051..908347 Staphylococcus aureus subsp. aureus MRSA252 2860887 YP_040293.1 CDS SAR0870 NC_002952.2 908597 909622 D Similar to Bacillus halodurans ABC transporter ATP-binding protein BH3481 TR:Q9K789 (EMBL:AP001518) (338 aa) fasta scores: E(): 3.2e-62, 54.734% id in 338 aa, and to Bacillus subtilis hypothetical protein YusC TR:O32169 (EMBL:Z99120) (341 aa) fasta scores: E(): 1.3e-61, 53.824% id in 340 aa; ABC transporter ATP-binding protein 908597..909622 Staphylococcus aureus subsp. aureus MRSA252 2860888 YP_040294.1 CDS SAR0871 NC_002952.2 909615 910310 D Similar to Bacillus subtilis hypothetical protein YusB TR:O32168 (EMBL:Z99120) (222 aa) fasta scores: E(): 5.4e-46, 64.352% id in 216 aa, and to Bacillus halodurans hypothetical protein BH3480 TR:Q9K790 (EMBL:AP001518) (218 aa) fasta scores: E(): 1.2e-41, 59.447% id in 217 aa; ABC transporter permease 909615..910310 Staphylococcus aureus subsp. aureus MRSA252 2860889 YP_040295.1 CDS SAR0872 NC_002952.2 910328 911149 D Similar to Bacillus subtilis hypothetical protein YusA TR:O32167 (EMBL:Z99120) (274 aa) fasta scores: E(): 2.5e-48, 55.839% id in 274 aa, and to Campylobacter jejuni periplasmic protein CJ0772C TR:Q9PPE7 (EMBL:AL139076) (257 aa) fasta scores: E(): 2e-37, 50.207% id in 241 aa; lipoprotein 910328..911149 Staphylococcus aureus subsp. aureus MRSA252 2860890 YP_040296.1 CDS SAR0874 NC_002952.2 911965 912159 D Similar to Bacillus subtilis sigmaB regulated hypothetical protein CsbD SW:CSBD_BACSU (P70964) (62 aa) fasta scores: E(): 0.0038, 42.553% id in 47 aa, and to Streptococcus pyogenes hypothetical protein SPY1261 TR:Q99ZE6 (EMBL:AE006565) (66 aa) fasta scores: E(): 0.00068, 44.776% id in 67 aa. Similar to SAR1705, 79.661% identity (79.661% ungapped) in 59 aa overlap; hypothetical protein 911965..912159 Staphylococcus aureus subsp. aureus MRSA252 2860891 YP_040297.1 CDS SAR0875 NC_002952.2 912393 913244 R Similar to an internal region of Staphylococcus carnosus PTS system, glucose-specific IIABC component GlcB TR:Q53922 (EMBL:X93360) (692 aa) fasta scores: E(): 0.74, 25.163% id in 306 aa, and to Bacillus halodurans BH2069 TR:Q9KB62 (EMBL:AP001514) (278 aa) fasta scores: E(): 9.6e-35, 44.528% id in 265 aa; hypothetical protein complement(912393..913244) Staphylococcus aureus subsp. aureus MRSA252 2860892 YP_040298.1 CDS SAR0876 NC_002952.2 913572 914333 D Similar to Bacillus subtilis hypothetical protein YurI SW:V296_BACSU (P80866) (260 aa) fasta scores: E(): 3.5e-65, 80.321% id in 249 aa, and to Cyanophora paradoxa probable ATP-dependent transporter Ycf16 SW:ABCX_CYAPA (P48255) (259 aa) fasta scores: E(): 6.5e-44, 56.327% id in 245 aa; ABC transporter ATP-binding protein 913572..914333 Staphylococcus aureus subsp. aureus MRSA252 2860893 YP_040299.1 CDS SAR0877 NC_002952.2 914431 915738 D Similar to Bacillus subtilis hypothetical protein YurX TR:O32165 (EMBL:Z99120) (437 aa) fasta scores: E(): 7.8e-89, 56.977% id in 430 aa, and to Bacillus halodurans hypothetical protein BH3470 TR:Q9K799 (EMBL:AP001518) (435 aa) fasta scores: E(): 4.3e-83, 53.613% id in 429 aa; hypothetical protein 914431..915738 Staphylococcus aureus subsp. aureus MRSA252 2859726 YP_040300.1 CDS csdB NC_002952.2 915853 917094 D Similar to Escherichia coli selenocysteine lyase CsdB SW:CSDB_ECOLI (P77444) (406 aa) fasta scores: E(): 4.9e-73, 48.148% id in 405 aa, and to Bacillus halodurans probable cysteine desulfurase Csd SW:CSD_BACHD (Q9K7A0) (406 aa) fasta scores: E(): 2.8e-108, 66.585% id in 407 aa; selenocysteine lyase 915853..917094 Staphylococcus aureus subsp. aureus MRSA252 2859246 YP_040301.1 CDS SAR0879 NC_002952.2 917084 917548 D Similar to Bacillus subtilis NifU-like protein NifU SW:NIFU_BACSU (O32163) (147 aa) fasta scores: E(): 3.5e-37, 70.548% id in 146 aa, and to Bacillus halodurans nitrogen fixation protein BH3468 TR:Q9K7A1 (EMBL:AP001518) (146 aa) fasta scores: E(): 1.3e-34, 64.626% id in 147 aa; NifU-like protein 917084..917548 Staphylococcus aureus subsp. aureus MRSA252 2859911 YP_040302.1 CDS SAR0880 NC_002952.2 917699 919096 D Similar to Bacillus subtilis hypothetical protein YurU TR:O32162 (EMBL:Z99120) (465 aa) fasta scores: E(): 1.2e-157, 84.516% id in 465 aa, and to Bacillus halodurans hypothetical protein BH3467 TR:Q9K7A2 (EMBL:AP001518) (465 aa) fasta scores: E(): 2.5e-154, 82.366% id in 465 aa; hypothetical protein 917699..919096 Staphylococcus aureus subsp. aureus MRSA252 2859912 YP_040303.1 CDS SAR0881 NC_002952.2 919428 919742 R hypothetical protein complement(919428..919742) Staphylococcus aureus subsp. aureus MRSA252 2861688 YP_040304.1 CDS SAR0882 NC_002952.2 920111 921151 D Similar to the N-terminal regions of Vibrio cholerae hemolysin VC0558 TR:Q9KUG3 (EMBL:AE004141) (426 aa) fasta scores: E(): 7.1e-26, 28.446% id in 341 aa, and Thermotoga maritima hemolysin-related protein TM0845 TR:Q9WZU9 (EMBL:AE001751) (455 aa) fasta scores: E(): 7.9e-27, 34.024% id in 338 aa; hypothetical protein 920111..921151 Staphylococcus aureus subsp. aureus MRSA252 2861689 YP_040305.1 CDS SAR0883 NC_002952.2 921165 922232 D Similar to Williopsis mrakii 2-nitropropane dioxygenase SW:2NPD_WILMR (Q12723) (374 aa) fasta scores: E(): 2e-13, 30.240% id in 334 aa, and to Bacillus halodurans hypothetical protein BH1205 TR:Q9KDK7 (EMBL:AP001511) (365 aa) fasta scores: E(): 1.7e-46, 44.857% id in 350 aa; dioxygenase 921165..922232 Staphylococcus aureus subsp. aureus MRSA252 2861690 YP_040306.1 CDS SAR0884 NC_002952.2 922532 923380 D Similar to Bacillus subtilis hypothetical protein YunF TR:O32135 (EMBL:Z99120) (284 aa) fasta scores: E(): 9.7e-60, 53.004% id in 283 aa, and to Bacillus halodurans hypothetical protein BH3455 TR:Q9K7B1 (EMBL:AP001518) (282 aa) fasta scores: E(): 2.6e-56, 50.177% id in 283 aa; hypothetical protein 922532..923380 Staphylococcus aureus subsp. aureus MRSA252 2861691 YP_040307.1 CDS SAR0885 NC_002952.2 923393 924220 D Similar to Bacillus subtilis hypothetical protein YunE TR:O32134 (EMBL:Z99120) (273 aa) fasta scores: E(): 7.3e-42, 41.544% id in 272 aa, and to Bacillus halodurans hypothetical protein BH3454 TR:Q9K7B2 (EMBL:AP001518) (273 aa) fasta scores: E(): 1.9e-41, 43.939% id in 264 aa; hypothetical protein 923393..924220 Staphylococcus aureus subsp. aureus MRSA252 2861692 YP_040308.1 CDS SAR0886 NC_002952.2 924247 925566 D N-terminus is similar to the N-terminal region of Boophilus microplus 5'-nucleotidase precursor protein SW:5NTD_BOOMI (P52307) (580 aa) fasta scores: E(): 2.8e-05, 22.302% id in 417 aa. Full length CDS is similar to Lactococcus lactis hypothetical protein YbiB TR:Q9CJ29 (EMBL:AE006255) (447 aa) fasta scores: E(): 2.6e-50, 36.585% id in 451 aa; 5'-nucleotidase 924247..925566 Staphylococcus aureus subsp. aureus MRSA252 2861693 YP_040309.1 CDS lipA NC_002952.2 925650 926567 D catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 925650..926567 Staphylococcus aureus subsp. aureus MRSA252 2859805 YP_040310.1 CDS SAR0888 NC_002952.2 926696 927079 D N-terminus is similar to Bacillus halodurans hypothetical protein BH3433 TR:Q9K7D1 (EMBL:AP001518) (93 aa) fasta scores: E(): 4.5e-19, 53.261% id in 92 aa, and to Bacillus subtilis hypothetical protein YutD TR:O32127 (EMBL:Z99120) (102 aa) fasta scores: E(): 1.4e-18, 58.242% id in 91 aa; hypothetical protein 926696..927079 Staphylococcus aureus subsp. aureus MRSA252 2861694 YP_040311.1 CDS SAR0889 NC_002952.2 927158 927424 R Poor database matches. Similar to Bacillus halodurans hypothetical protein BH3432 TR:Q9K7D2 (EMBL:AP001518) (88 aa) fasta scores: E(): 4.3e-15, 50.602% id in 83 aa; hypothetical protein complement(927158..927424) Staphylococcus aureus subsp. aureus MRSA252 2861695 YP_040312.1 CDS SAR0890 NC_002952.2 927522 927956 D Similar to Bacillus halodurans hypothetical protein BH3430 TR:Q9K7D4 (EMBL:AP001518) (151 aa) fasta scores: E(): 6.2e-15, 37.762% id in 143 aa, and to Bacillus subtilis hypothetical protein YutE TR:O32126 (EMBL:Z99120) (144 aa) fasta scores: E(): 7.4e-11, 33.566% id in 143 aa; hypothetical protein 927522..927956 Staphylococcus aureus subsp. aureus MRSA252 2861696 YP_040313.1 CDS SAR0891 NC_002952.2 927956 928735 D Similar to Bacillus subtilis hypothetical protein YutF TR:O32125 (EMBL:Z99120) (256 aa) fasta scores: E(): 2.4e-45, 53.543% id in 254 aa, and to Streptococcus pyogenes hypothetical protein SPY1043 TR:Q99ZW4 (EMBL:AE006549) (254 aa) fasta scores: E(): 3e-38, 48.000% id in 250 aa; haloacid dehalogenase-like hydrolase 927956..928735 Staphylococcus aureus subsp. aureus MRSA252 2861697 YP_040314.1 CDS SAR0892 NC_002952.2 928768 929727 D Similar to Bacillus halodurans glycerate dehydrogenase BH3314 TR:Q9K7P7 (EMBL:AP001518) (324 aa) fasta scores: E(): 4.6e-52, 45.066% id in 304 aa, and to Pyrococcus abyssi glycerate dehydrogenase PAB2374 TR:Q9UYR1 (EMBL:AJ248287) (335 aa) fasta scores: E(): 5e-49, 41.745% id in 321 aa; D-isomer specific 2-hydroxyacid dehydrogenase 928768..929727 Staphylococcus aureus subsp. aureus MRSA252 2861698 YP_040315.1 CDS SAR0893 NC_002952.2 930138 930290 D hypothetical protein 930138..930290 Staphylococcus aureus subsp. aureus MRSA252 2861699 YP_040316.1 CDS dltA NC_002952.2 930306 931763 D transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 930306..931763 Staphylococcus aureus subsp. aureus MRSA252 2859593 YP_040317.1 CDS dltB NC_002952.2 931760 932974 D Similar to Bacillus subtilis activated D-alanine transport protein DltB SW:DLTB_BACSU (P39580) (395 aa) fasta scores: E(): 3.1e-68, 52.334% id in 407 aa. Previously sequenced as Staphylococcus aureus hypothetical membrane transporter DltB TR:Q53662 (EMBL:D86240) (404 aa) fasta scores: E(): 1e-158, 100.000% id in 404 aa; activated D-alanine transport protein 931760..932974 Staphylococcus aureus subsp. aureus MRSA252 2859594 YP_040318.1 CDS dltC NC_002952.2 932992 933228 D D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 932992..933228 Staphylococcus aureus subsp. aureus MRSA252 2859595 YP_040319.1 CDS dltD NC_002952.2 933225 934400 D Similar to Bacillus subtilis lipoteichoic acid biosynthesis protein DltD SW:DLTD_BACSU (P39578) (392 aa) fasta scores: E(): 1.2e-40, 32.216% id in 388 aa. Previously sequenced as Staphylococcus aureus exoprotein DltD TR:Q9S674 (EMBL:AF101234) (391 aa) fasta scores: E(): 3.5e-147, 100.000% id in 391 aa; lipoteichoic acid biosynthesis protein 933225..934400 Staphylococcus aureus subsp. aureus MRSA252 2859596 YP_040320.1 CDS SAR0898 NC_002952.2 934662 934904 R Similar to Bacillus halodurans nitrogen fixation protein BH3419 TR:Q9K7E5 (EMBL:AP001518) (79 aa) fasta scores: E(): 1.1e-20, 77.333% id in 75 aa, and to Synechocystis sp hypothetical protein SSL2667 TR:P74558 (EMBL:D90916) (76 aa) fasta scores: E(): 1.6e-12, 51.389% id in 72 aa; hypothetical protein complement(934662..934904) Staphylococcus aureus subsp. aureus MRSA252 2861700 YP_040321.1 CDS SAR0899 NC_002952.2 935005 935328 D Similar to Bacillus subtilis hypothetical protein YuzD TR:O32118 (EMBL:Z99120) (108 aa) fasta scores: E(): 1.9e-14, 43.925% id in 107 aa, and to Bacillus halodurans hypothetical protein BH3416 TR:Q9K7E6 (EMBL:AP001518) (101 aa) fasta scores: E(): 1.3e-10, 37.755% id in 98 aa; hypothetical protein 935005..935328 Staphylococcus aureus subsp. aureus MRSA252 2861701 YP_040322.1 CDS SAR0900 NC_002952.2 935388 936452 R Similar to Bacillus subtilis YutJ TR:O32117 (EMBL:Z99120) (330 aa) fasta scores: E(): 6.1e-70, 54.799% id in 323 aa, and to Sulfolobus solfataricus NADH oxidase SSO3148 TR:AAK43249 (EMBL:AE006905) (350 aa) fasta scores: E(): 3.2e-12, 26.087% id in 345 aa; pyridine nucleotide-disulfide oxidoreductase complement(935388..936452) Staphylococcus aureus subsp. aureus MRSA252 2861702 YP_040323.1 CDS SAR0901 NC_002952.2 936769 937005 D Similar to Bacillus subtilis hypothetical protein YuzB TR:O32116 (EMBL:Z99120) (78 aa) fasta scores: E(): 1.5e-16, 53.846% id in 78 aa, and to Bacillus halodurans hypothetical protein BH3414 TR:Q9K7E8 (EMBL:AP001518) (78 aa) fasta scores: E(): 1.8e-15, 50.000% id in 78 aa; hypothetical protein 936769..937005 Staphylococcus aureus subsp. aureus MRSA252 2861703 YP_040324.1 CDS SAR0902 NC_002952.2 937018 937377 D Similar to Bacillus subtilis hypothetical protein YutM SW:YUTM_BACSU (O32113) (120 aa) fasta scores: E(): 5.7e-26, 59.483% id in 116 aa, and to Bacillus halodurans hypothetical protein BH3410 TR:Q9K7F2 (EMBL:AP001518) (117 aa) fasta scores: E(): 1.1e-21, 52.137% id in 117 aa; hypothetical protein 937018..937377 Staphylococcus aureus subsp. aureus MRSA252 2861704 YP_040325.1 CDS SAR0903 NC_002952.2 937831 939039 D Similar to Bacillus subtilis hypothetical protein YumB TR:O05267 (EMBL:Z93939) (406 aa) fasta scores: E(): 1.5e-77, 52.723% id in 404 aa, and to Bacillus halodurans NADH dehydrogenase BH3407 TR:Q9K7F4 (EMBL:AP001518) (400 aa) fasta scores: E(): 1.7e-65, 47.750% id in 400 aa; pyridine nucleotide-disulfide oxidoreductase 937831..939039 Staphylococcus aureus subsp. aureus MRSA252 2861705 YP_040326.1 CDS pepA NC_002952.2 939170 940645 D Similar to Pseudomonas aeruginosa cytosol aminopeptidase PepA SW:AMPA_PSEAE (O68822) (495 aa) fasta scores: E(): 3.9e-46, 36.504% id in 452 aa, and to Bacillus subtilis probable cytosol aminopeptidase pepA SW:AMPA_BACSU (O32106) (500 aa) fasta scores: E(): 8e-51, 35.185% id in 486 aa; cytosol aminopeptidase 939170..940645 Staphylococcus aureus subsp. aureus MRSA252 2859893 YP_040327.1 CDS SAR0905 NC_002952.2 941056 942372 D Similar to Escherichia coli high-affinity gluconate transporter GntT SW:GNTT_ECOLI (P39835) (437 aa) fasta scores: E(): 1.3e-05, 20.844% id in 403 aa, and to Bacillus halodurans hypothetical protein BH3359 TR:Q9K7K2 (EMBL:AP001518) (440 aa) fasta scores: E(): 2.3e-78, 49.091% id in 440 aa; transporter protein 941056..942372 Staphylococcus aureus subsp. aureus MRSA252 2861706 YP_040328.1 CDS SAR0906 NC_002952.2 942391 942765 D Similar to Bacillus subtilis hypothetical protein YuxO TR:Q9FAE9 (EMBL:AB039951) (127 aa) fasta scores: E(): 2.8e-16, 47.863% id in 117 aa, and to C-terminal region of Pseudomonas aeruginosa hypothetical protein PA1618 SW:YG18_PSEAE (Q9I3A4) (145 aa) fasta scores: E(): 3.2e-16, 44.444% id in 108 aa; hypothetical protein 942391..942765 Staphylococcus aureus subsp. aureus MRSA252 2861707 YP_040329.1 CDS SAR0907 NC_002952.2 942821 943975 R Poor database matches. N-terminus is similar to the N-terminal regions of Bacillus subtilis hypothetical protein YrdP TR:O07085 (EMBL:U93876) (345 aa) fasta scores: E(): 5, 22.508% id in 311 aa, and Mycobacterium tuberculosis monooxygenase Rv1393c TR:P71662 (EMBL:Z80108) (492 aa) fasta scores: E(): 8, 22.843% id in 197 aa; hypothetical protein complement(942821..943975) Staphylococcus aureus subsp. aureus MRSA252 2861708 YP_040330.1 CDS mnhG NC_002952.2 944238 944594 R subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit G complement(944238..944594) Staphylococcus aureus subsp. aureus MRSA252 2861172 YP_040331.1 CDS mnhF NC_002952.2 944572 944865 R subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit F complement(944572..944865) Staphylococcus aureus subsp. aureus MRSA252 2861171 YP_040332.1 CDS mnhE NC_002952.2 944865 945344 R subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit E complement(944865..945344) Staphylococcus aureus subsp. aureus MRSA252 2861170 YP_040333.1 CDS mnhD NC_002952.2 945346 946842 R subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; monovalent cation/H+ antiporter subunit D complement(945346..946842) Staphylococcus aureus subsp. aureus MRSA252 2861169 YP_040334.1 CDS mnhC NC_002952.2 946835 947176 R subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit C complement(946835..947176) Staphylococcus aureus subsp. aureus MRSA252 2861168 YP_040335.1 CDS mnhB NC_002952.2 947176 947604 R subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in the case of S. meliloti it was proved to be involved specifically with K+ transport; monovalent cation/H+ antiporter subunit B complement(947176..947604) Staphylococcus aureus subsp. aureus MRSA252 2861167 YP_040336.1 CDS mnhA NC_002952.2 947597 950002 R subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit A complement(947597..950002) Staphylococcus aureus subsp. aureus MRSA252 2861166 YP_040337.1 CDS SAR0915 NC_002952.2 950133 950516 R Poor database matches. Similar to Bacillus subtilis kinase-associated protein B KapB SW:KAPB_BACSU (Q08429) (128 aa) fasta scores: E(): 3.2e-08, 36.036% id in 111 aa. Previously sequenced as Staphylococcus aureus hypothetical protein OrfA TR:Q9ZNG7 (EMBL:AB015981) (127 aa) fasta scores: E(): 7.5e-45, 99.213% id in 127 aa; hypothetical protein complement(950133..950516) Staphylococcus aureus subsp. aureus MRSA252 2861709 YP_040338.1 CDS SAR0916 NC_002952.2 950580 951173 D Similar to Caenorhabditis elegans cyclophilin isoform 10, peptidyl-prolyl cis-trans isomerase 10, CYP-10 SW:CYPA_CAEEL (P52017) (147 aa) fasta scores: E(): 8.2e-17, 42.105% id in 171 aa, and to Lactococcus lactis peptidyl-prolyl cis-trans isomerase PpiB TR:Q9CH46 (EMBL:AE006323) (196 aa) fasta scores: E(): 7.7e-43, 60.204% id in 196 aa; cyclophilin type peptidyl-prolyl cis-trans isomerase 950580..951173 Staphylococcus aureus subsp. aureus MRSA252 2861710 YP_040339.1 CDS SAR0917 NC_002952.2 951588 951965 D Similar to Bacillus subtilis general stress protein 13 YugI SW:GS13_BACSU (P80870) (129 aa) fasta scores: E(): 2.7e-09, 35.000% id in 120 aa, and to Bacillus halodurans polyribonucleotide nucleotidyltransferase BH3347 TR:Q9K7L4 (EMBL:AP001518) (138 aa) fasta scores: E(): 1.3e-09, 36.364% id in 132 aa; S1 RNA-binding domain-containing protein 951588..951965 Staphylococcus aureus subsp. aureus MRSA252 2861711 YP_040340.1 CDS SAR0918 NC_002952.2 952327 953454 D Similar to the N-terminal region of Thermoanaerobacter brockii NADH oxidase SW:NADO_THEBR (P32382) (651 aa) fasta scores: E(): 2.2e-25, 32.670% id in 352 aa, and to Bacillus subtilis probable NADH-dependent flavin oxidoreductase YqiG SW:YQIG_BACSU (P54524) (372 aa) fasta scores: E(): 3.3e-62, 47.354% id in 378 aa; NADH:flavin oxidoreductase / NADH oxidase 952327..953454 Staphylococcus aureus subsp. aureus MRSA252 2861712 YP_040341.1 CDS rocD NC_002952.2 953762 954952 D Similar to Bacillus subtilis ornithine aminotransferase RocD SW:OAT_BACSU (P38021) (401 aa) fasta scores: E(): 3.6e-115, 73.990% id in 396 aa, and to Bacillus halodurans ornithine aminotransferase RocD TR:Q9K5Z2 (EMBL:AP001520) (400 aa) fasta scores: E(): 2.4e-109, 71.646% id in 395 aa. Similar to SAR0186, 57.179% identity (57.179% ungapped) in 390 aa overlap; ornithine--oxo-acid transaminase 953762..954952 Staphylococcus aureus subsp. aureus MRSA252 2859280 YP_040342.1 CDS SAR0920 NC_002952.2 955061 956305 D Similar to Bacillus subtilis NAD-specific glutamate dehydrogenase RocG SW:DHE2_BACSU (P39633) (424 aa) fasta scores: E(): 6.7e-124, 73.479% id in 411 aa, and to Bacillus halodurans glutamate dehydrogenase BH1622 TR:Q9KCE9 (EMBL:AP001512) (421 aa) fasta scores: E(): 1.2e-126, 75.669% id in 411 aa; NAD-specific glutamate dehydrogenase 955061..956305 Staphylococcus aureus subsp. aureus MRSA252 2861713 YP_040343.1 CDS glpQ NC_002952.2 956700 957629 R Similar to Bacillus subtilis glycerophosphoryl diester phosphodiesterase GlpQ SW:GLPQ_BACSU (P37965) (293 aa) fasta scores: E(): 6.5e-52, 54.023% id in 261 aa, and to Bacillus halodurans glycerophosphoryl diester phosphodiesterase GlpQ TR:Q9K6M8 (EMBL:AP001519) (284 aa) fasta scores: E(): 1.8e-19, 39.041% id in 292 aa; glycerophosphoryl diester phosphodiesterase complement(956700..957629) Staphylococcus aureus subsp. aureus MRSA252 2859928 YP_040344.1 CDS argH NC_002952.2 957871 959250 R catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase complement(957871..959250) Staphylococcus aureus subsp. aureus MRSA252 2859854 YP_040345.1 CDS argG NC_002952.2 959240 960445 R catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase complement(959240..960445) Staphylococcus aureus subsp. aureus MRSA252 2859853 YP_040346.1 CDS pgi NC_002952.2 960796 962127 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 960796..962127 Staphylococcus aureus subsp. aureus MRSA252 2861714 YP_040347.1 CDS SAR0925 NC_002952.2 962453 963028 D Similar to Bacillus subtilis hypothetical protein YhjE TR:O07559 (EMBL:Y14081) (207 aa) fasta scores: E(): 9e-22, 33.161% id in 193 aa, and to Staphylococcus carnosus hypothetical protein TR:Q9ZG07 (EMBL:AF089862) (225 aa) fasta scores: E(): 2.5e-31, 41.398% id in 186 aa. CDS is truncated at the N-terminus in comparison to other orthologues; hypothetical protein 962453..963028 Staphylococcus aureus subsp. aureus MRSA252 2861715 YP_040348.1 CDS spsA NC_002952.2 963033 963557 D Similar to Bacillus subtilis signal peptidase I SipS SW:LEPS_BACSU (P28628) (184 aa) fasta scores: E(): 1.9e-12, 28.655% id in 171 aa. Previously sequenced as Staphylococcus aureus inactive signal peptidase Ia SpsA SW:LEPH_STAAU (P72364) (174 aa) fasta scores: E(): 2.5e-64, 98.851% id in 174 aa. The Staphylococcus aureus signal peptidase I is thought to be inactive as it lacks essential catalytic residues; signal peptidase Ia 963033..963557 Staphylococcus aureus subsp. aureus MRSA252 2859159 YP_040349.1 CDS spsB NC_002952.2 963573 964148 D Previously sequenced as Staphylococcus aureus signal peptidase Ib SpsB SW:LEP_STAAU (P72365) (191 aa) fasta scores: E(): 6.3e-72, 98.953% id in 191 aa. Similar to Staphylococcus carnosus type-I signal peptidase SipB TR:Q9ZG05 (EMBL:AF089862) (189 aa) fasta scores: E(): 6.8e-51, 70.588% id in 187 aa; signal peptidase Ib 963573..964148 Staphylococcus aureus subsp. aureus MRSA252 2859160 YP_040350.1 CDS SAR0928 NC_002952.2 964308 967784 D Similar to Bacillus subtilis ATP-dependent nuclease subunit B AddB SW:ADDB_BACSU (P23477) (1166 aa) fasta scores: E(): 2.5e-21, 31.014% id in 1164 aa, and to Lactococcus lactis subunit B of ATP-dependent exonuclease RexB TR:Q9CJJ0 (EMBL:AE006239) (1099 aa) fasta scores: E(): 1e-15, 21.303% id in 1136 aa; hypothetical protein 964308..967784 Staphylococcus aureus subsp. aureus MRSA252 2861716 YP_040351.1 CDS SAR0929 NC_002952.2 967785 971438 D Similar to Bacillus subtilis ATP-dependent nuclease subunit A AddA SW:ADDA_BACSU (P23478) (1232 aa) fasta scores: E(): 2.3e-94, 37.070% id in 1249 aa, and to Lactococcus lactis subunit A of ATP-dependent exonuclease RexA TR:Q9CJI9 (EMBL:AE006239) (1203 aa) fasta scores: E(): 1e-72, 29.841% id in 1260 aa; hypothetical protein 967785..971438 Staphylococcus aureus subsp. aureus MRSA252 2861717 YP_040352.1 CDS SAR0930 NC_002952.2 971604 972506 D Similar to Bacillus subtilis hypothetical protein YisK TR:O06724 (EMBL:Y09476) (301 aa) fasta scores: E(): 4e-39, 40.924% id in 303 aa, and to Bacillus halodurans 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase BH2000 TR:Q9KBC8 (EMBL:AP001514) (319 aa) fasta scores: E(): 1.5e-29, 34.936% id in 312 aa; fumarylacetoacetate (FAA) hydrolase 971604..972506 Staphylococcus aureus subsp. aureus MRSA252 2861718 YP_040353.1 CDS SAR0931 NC_002952.2 972832 973221 D Similar to Bacillus subtilis hypothetical protein YisL TR:O06725 (EMBL:Y09476) (118 aa) fasta scores: E(): 4.4e-09, 34.711% id in 121 aa, and to Bacillus halodurans hypothetical protein BH2983 TR:Q9K8M3 (EMBL:AP001517) (124 aa) fasta scores: E(): 0.0033, 27.193% id in 114 aa; hypothetical protein 972832..973221 Staphylococcus aureus subsp. aureus MRSA252 2861719 YP_040354.1 CDS SAR0932 NC_002952.2 973598 975244 D Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 5e-197, 98.540% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 2.3e-97, 51.346% id in 520 aa; transposase 973598..975244 Staphylococcus aureus subsp. aureus MRSA252 2861720 YP_040355.1 CDS SAR0933 NC_002952.2 975316 976632 R NADPH-dependent; catalyzes the reduction of coenzyme A disulfide; coenzyme A disulfide reductase complement(975316..976632) Staphylococcus aureus subsp. aureus MRSA252 2861721 YP_040356.1 CDS SAR0934 NC_002952.2 976684 977508 R Similar to Bacillus subtilis hypothetical protein YitU TR:P70947 (EMBL:Z79580) (270 aa) fasta scores: E(): 1.1e-48, 47.191% id in 267 aa, and to Bacillus halodurans BH2906 TR:Q9K8U6 (EMBL:AP001517) (269 aa) fasta scores: E(): 8.2e-48, 49.064% id in 267 aa; haloacid dehalogenase-like hydrolase complement(976684..977508) Staphylococcus aureus subsp. aureus MRSA252 2861722 YP_040357.1 CDS SAR0935 NC_002952.2 977622 977930 D Similar to Bacillus subtilis hypothetical protein YitW TR:P70949 (EMBL:Z79580) (102 aa) fasta scores: E(): 1.1e-27, 68.317% id in 101 aa, and to Bacillus halodurans hypothetical protein BH2173 TR:Q9KAW3 (EMBL:AP001514) (111 aa) fasta scores: E(): 2.7e-21, 66.000% id in 100 aa; hypothetical protein 977622..977930 Staphylococcus aureus subsp. aureus MRSA252 2861723 YP_040358.1 CDS SAR0936 NC_002952.2 977943 978068 R No significant database matches. Doubtful CDS; hypothetical protein complement(977943..978068) Staphylococcus aureus subsp. aureus MRSA252 2859419 YP_040359.1 CDS SAR0937 NC_002952.2 978510 980324 D Similar to Bacillus subtilis hypothetical protein YrhL TR:O05402 (EMBL:U93874) (634 aa) fasta scores: E(): 8.8e-52, 38.328% id in 634 aa, and to Lactococcus lactis hypothetical protein YvhB TR:Q9CDV4 (EMBL:AE006439) (605 aa) fasta scores: E(): 5.4e-42, 33.223% id in 605 aa. Simililar to SAR2649, 57.475% identity (58.545% ungapped) in 602 aa overlap; hypothetical protein 978510..980324 Staphylococcus aureus subsp. aureus MRSA252 2859420 YP_040360.1 CDS clpB NC_002952.2 980527 983136 D Similar to Escherichia coli ATPase subunit of an ATP-dependent protease, and heat shock protein, ClpB SW:CLPB_ECOLI (P03815) (857 aa) fasta scores: E(): 1.5e-128, 52.723% id in 863 aa, and to Lactococcus lactis ClpB homologue TR:Q9CFF3 (EMBL:AE006383) (867 aa) fasta scores: E(): 2.4e-156, 60.596% id in 873 aa. Contains coiled-coiled domain, residues 440 to 485; ATPase of an ATP-dependent protease 980527..983136 Staphylococcus aureus subsp. aureus MRSA252 2859233 YP_040361.1 CDS SAR0939 NC_002952.2 983195 984064 R N-terminus is similar the N-terminal region of Bacillus subtilis citrate synthase I repressor CitR SW:CITR_BACSU (P39127) (308 aa) fasta scores: E(): 1.9e-15, 26.016% id in 246 aa. Full length CDS is similar to Bacillus subtilis hypothetical transcriptional regulator YxjO SW:YXJO_BACSU (P55181) (291 aa) fasta scores: E(): 2.2e-27, 29.010% id in 293 aa; LysR family regulatory protein complement(983195..984064) Staphylococcus aureus subsp. aureus MRSA252 2859421 YP_040362.1 CDS SAR0940 NC_002952.2 984175 985320 D Similar to the N-terminal regions of Lactococcus lactis 2-isopropylmalate synthase LeuA SW:LEU1_LACLA (Q02141) (513 aa) fasta scores: E(): 2.2e-29, 33.777% id in 376 aa, and Bacillus subtilis 2-isopropylmalate synthase LeuA SW:LEU1_BACSU (P94565) (518 aa) fasta scores: E(): 2.6e-28, 33.422% id in 377 aa; hypothetical protein 984175..985320 Staphylococcus aureus subsp. aureus MRSA252 2859422 YP_040363.1 CDS SAR0941 NC_002952.2 985304 985945 D Similar to the N-terminal regions of Archaeoglobus fulgidus conserved hypothetical protein AF0781 TR:O29477 (EMBL:AE001051) (309 aa) fasta scores: E(): 8.5e-10, 25.962% id in 208 aa, and Pyrococcus horikoshii hypothetical protein PH0435 TR:O73972 (EMBL:AP000002) (340 aa) fasta scores: E(): 4.5e-09, 32.812% id in 192 aa; hypothetical protein 985304..985945 Staphylococcus aureus subsp. aureus MRSA252 2859423 YP_040364.1 CDS SAR0942 NC_002952.2 985938 987056 D Poor database matches. Similar to Helicobacter pylori hypothetical protein TR:Q9F7U3 (EMBL:AF275307) (387 aa) fasta scores: E(): 0.078, 25.575% id in 348 aa; hypothetical protein 985938..987056 Staphylococcus aureus subsp. aureus MRSA252 2859424 YP_040365.1 CDS SAR0943 NC_002952.2 987040 987555 D Similar to Bacillus subtilis hypothetical protein YxkA TR:P94355 (EMBL:D83026) (168 aa) fasta scores: E(): 4.5e-26, 46.875% id in 160 aa, and to Pasteurella multocida hypothetical protein PM1470 TR:Q9CKY1 (EMBL:AE006183) (170 aa) fasta scores: E(): 2e-17, 44.286% id in 140 aa; hypothetical protein 987040..987555 Staphylococcus aureus subsp. aureus MRSA252 2859425 YP_040366.1 CDS SAR0944 NC_002952.2 987866 988300 D Poor database matches. Similar to N-terminal region of Staphylococcus aureus MHC class II analogue TR:Q53599 (EMBL:U20503) (689 aa) fasta scores: E(): 9.7e-11, 45.946% id in 148 aa; hypothetical protein 987866..988300 Staphylococcus aureus subsp. aureus MRSA252 2859426 YP_040367.1 CDS SAR0945 NC_002952.2 988557 988742 R Poor database matches. Similar to Bacillus subtilis YjzD TR:O34713 (EMBL:Z99109) (61 aa) fasta scores: E(): 0.3, 22.951% id in 61 aa; hypothetical protein complement(988557..988742) Staphylococcus aureus subsp. aureus MRSA252 2859427 YP_040368.1 CDS fabH NC_002952.2 989038 989979 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 989038..989979 Staphylococcus aureus subsp. aureus MRSA252 2859620 YP_040369.1 CDS fabF NC_002952.2 989991 991235 D Similar to Vibrio harveyi 3-oxoacyl-[acyl-carrier-protein] synthase II FabF SW:FABF_VIBHA (P55338) (414 aa) fasta scores: E(): 4.9e-78, 52.206% id in 408 aa, and to Bacillus subtilis hypothetical protein YjaY TR:O34340 (EMBL:Z99109) (413 aa) fasta scores: E(): 4.7e-106, 67.971% id in 409 aa; 3-oxoacyl-ACP synthase 989991..991235 Staphylococcus aureus subsp. aureus MRSA252 2859618 YP_040370.1 CDS SAR0948 NC_002952.2 991290 991661 R No significant database matches. Doubtful CDS; hypothetical protein complement(991290..991661) Staphylococcus aureus subsp. aureus MRSA252 2859428 YP_040371.1 CDS oppB NC_002952.2 991904 992830 D Similar to Bacillus subtilis oligopeptide ABC transporter permease OppB SW:OPPB_BACSU (P24138) (311 aa) fasta scores: E(): 1.9e-55, 49.515% id in 309 aa, and to Bacillus thuringiensis hypothetical protein OppB TR:Q9F5U5 (EMBL:AF305387) (309 aa) fasta scores: E(): 4.5e-69, 60.194% id in 309 aa; oligopeptide ABC transporter permease 991904..992830 Staphylococcus aureus subsp. aureus MRSA252 2859181 YP_040372.1 CDS oppC NC_002952.2 992830 993900 D Similar to Bacillus subtilis oligopeptide ABC transporter permease OppC SW:OPPC_BACSU (P24139) (305 aa) fasta scores: E(): 2.4e-48, 46.815% id in 314 aa, and to Bacillus thuringiensis hypothetical protein OppC TR:Q9F5U4 (EMBL:AF305387) (337 aa) fasta scores: E(): 2.7e-72, 56.869% id in 313 aa; oligopeptide ABC transporter permease 992830..993900 Staphylococcus aureus subsp. aureus MRSA252 2859182 YP_040373.1 CDS oppD NC_002952.2 993916 994998 D Similar to Bacillus subtilis oligopeptide transport ATP-binding protein OppD SW:OPPD_BACSU (P24136) (358 aa) fasta scores: E(): 1.4e-80, 67.045% id in 352 aa, and to Listeria monocytogenes oligopeptide transport system ATPase OppD TR:Q9LAT4 (EMBL:AF103793) (358 aa) fasta scores: E(): 4.5e-78, 67.456% id in 338 aa. Similar to SAR0198, 50.763% identity (50.763% ungapped) in 262 aa overlap; oligopeptide transport ATP-binding protein 993916..994998 Staphylococcus aureus subsp. aureus MRSA252 2859183 YP_040374.1 CDS oppF NC_002952.2 994988 995929 D Similar to Bacillus subtilis oligopeptide transport ATP-binding protein OppF SW:OPPF_BACSU (P24137) (308 aa) fasta scores: E(): 2e-69, 66.890% id in 299 aa, and to Listeria monocytogenes oligopeptide transport system ATPase OppF TR:Q9LAT3 (EMBL:AF103793) (325 aa) fasta scores: E(): 6e-66, 63.407% id in 317 aa. Similar to SAR0958, 54.198% identity (55.686% ungapped) in 262 aa overlap; oligopeptide transport ATP-binding protein 994988..995929 Staphylococcus aureus subsp. aureus MRSA252 2859184 YP_040375.1 CDS SAR0953 NC_002952.2 995948 997603 D Similar to Listeria monocytogenes peptide binding protein OppA TR:Q9LAT7 (EMBL:AF103793) (558 aa) fasta scores: E(): 1.3e-72, 40.182% id in 550 aa, and to Bacillus thuringiensis hypothetical protein OppA TR:Q9F5U6 (EMBL:AF305387) (551 aa) fasta scores: E(): 4.9e-68, 37.658% id in 555 aa; transport system extracellular binding lipoprotein 995948..997603 Staphylococcus aureus subsp. aureus MRSA252 2859429 YP_040376.1 CDS SAR0955 NC_002952.2 998073 999020 R Identical to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 2.7e-127, 100.000% id in 315 aa, and similar to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 2.9e-71, 58.413% id in 315 aa; transposase complement(998073..999020) Staphylococcus aureus subsp. aureus MRSA252 2859431 YP_040377.1 CDS appD NC_002952.2 1000655 1001641 D Similar to Bacillus subtilis oligopeptide transport ATP-binding protein AppD SW:APPD_BACSU (P42064) (328 aa) fasta scores: E(): 5.4e-48, 47.546% id in 326 aa, and to Bacillus halodurans oligopeptide ABC transporter BH3646 TR:Q9K6T0 (EMBL:AP001519) (329 aa) fasta scores: E(): 3.8e-57, 52.280% id in 329 aa; oligopeptide transport ATP-binding protein 1000655..1001641 Staphylococcus aureus subsp. aureus MRSA252 2860992 YP_040378.1 CDS appF NC_002952.2 1001644 1002624 D Similar to Bacillus subtilis oligopeptide transport ATP-binding protein AppF SW:APPF_BACSU (P42065) (329 aa) fasta scores: E(): 3e-61, 57.994% id in 319 aa, and to Bacillus halodurans oligopeptide ABC transporter BH3645 TR:Q9K6T1 (EMBL:AP001519) (322 aa) fasta scores: E(): 4.6e-57, 54.777% id in 314 aa. SAR0952, 54.198% identity (55.686% ungapped) in 262 aa overlap; oligopeptide transport ATP-binding protein 1001644..1002624 Staphylococcus aureus subsp. aureus MRSA252 2860993 YP_040379.1 CDS appC NC_002952.2 1003279 1004160 D Similar to Bacillus subtilis oligopeptide ABC transporter permease AppC SW:APPC_BACSU (P42063) (303 aa) fasta scores: E(): 1.7e-42, 44.218% id in 294 aa, and to Pasteurella multocida hypothetical protein PM1908 TR:Q9CJT3 (EMBL:AE006228) (303 aa) fasta scores: E(): 8.6e-38, 38.014% id in 292 aa; oligopeptide ABC transporter permease 1003279..1004160 Staphylococcus aureus subsp. aureus MRSA252 2860991 YP_040380.1 CDS SAR0961 NC_002952.2 1004249 1005037 R Similar to the C-terminal region of Enterococcus faecium transposase TR:Q47815 (EMBL:L40841) (310 aa) fasta scores: E(): 1.9e-39, 46.183% id in 262 aa, and to the full length Neisseria gonorrhoeae hypothetical protein TR:Q50996 (EMBL:L36381) (267 aa) fasta scores: E(): 1.1e-27, 39.689% id in 257 aa; transposase complement(1004249..1005037) Staphylococcus aureus subsp. aureus MRSA252 2859433 YP_040381.1 CDS SAR0962 NC_002952.2 1005258 1005815 R Similar to the C-terminal regions of Mycoplasma mycoides insertion element IS1296 hypothetical protein SW:YI6A_MYCMY (Q50239) (180 aa) fasta scores: E(): 0.0016, 26.812% id in 138 aa, and Bacillus thuringiensis hypothetical protein TR:P94596 (EMBL:Y09946) (185 aa) fasta scores: E(): 0.011, 32.075% id in 106 aa; insertion element protein complement(1005258..1005815) Staphylococcus aureus subsp. aureus MRSA252 2859434 YP_040382.1 CDS SAR0963 NC_002952.2 1006111 1007757 D Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 1.5e-195, 97.993% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 2.5e-97, 51.346% id in 520 aa; transposase 1006111..1007757 Staphylococcus aureus subsp. aureus MRSA252 2859435 YP_040383.1 CDS trpS NC_002952.2 1007784 1008773 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(1007784..1008773) Staphylococcus aureus subsp. aureus MRSA252 2860404 YP_040384.1 CDS spxA NC_002952.2 1009068 1009463 D the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; Spx family transcriptional regulator 1009068..1009463 Staphylococcus aureus subsp. aureus MRSA252 2859436 YP_040385.1 CDS SAR0966 NC_002952.2 1009834 1010553 D enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 1009834..1010553 Staphylococcus aureus subsp. aureus MRSA252 2859437 YP_040386.1 CDS SAR0967 NC_002952.2 1010674 1011660 D N-terminus is similar to the N-terminal regions of Lactococcus lactis transcription factor TR:P94875 (EMBL:X99710) (327 aa) fasta scores: E(): 1.1e-10, 29.675% id in 246 aa, and Streptococcus pyogenes transcription factor SPY1395 TR:Q99Z52 (EMBL:AE006576) (320 aa) fasta scores: E(): 9.6e-09, 27.876% id in 226 aa; hypothetical protein 1010674..1011660 Staphylococcus aureus subsp. aureus MRSA252 2859438 YP_040387.1 CDS pepB NC_002952.2 1011708 1013516 D Similar to Streptococcus agalactiae group B oligopeptidase PepB SW:PEPB_STRAG (Q53778) (601 aa) fasta scores: E(): 1.9e-93, 44.974% id in 587 aa, and to Bacillus licheniformis Pz-peptidase TR:P70922 (EMBL:D88209) (628 aa) fasta scores: E(): 1.7e-126, 56.314% id in 586 aa; oligopeptidase 1011708..1013516 Staphylococcus aureus subsp. aureus MRSA252 2859894 YP_040388.1 CDS SAR0969 NC_002952.2 1013976 1014782 R Similar to Bacillus halodurans hypothetical protein BH2855 TR:Q9K8Z7 (EMBL:AP001516) (306 aa) fasta scores: E(): 4.4e-20, 32.103% id in 271 aa, and to Bacillus subtilis hypothetical protein YjbH TR:O31606 (EMBL:Z99110) (275 aa) fasta scores: E(): 9.7e-20, 33.206% id in 262 aa. Possible alternative translational start sites; hypothetical protein complement(1013976..1014782) Staphylococcus aureus subsp. aureus MRSA252 2859439 YP_040389.1 CDS SAR0970 NC_002952.2 1014805 1015170 R Similar to Tetrahymena pyriformis myoglobin SW:GLB_TETPY (P17724) (121 aa) fasta scores: E(): 0.00028, 31.373% id in 102 aa, and to Bacillus subtilis hypothetical protein YjbI TR:O31607 (EMBL:Z99110) (132 aa) fasta scores: E(): 3e-23, 53.448% id in 116 aa; hypothetical protein complement(1014805..1015170) Staphylococcus aureus subsp. aureus MRSA252 2859440 YP_040390.1 CDS SAR0971 NC_002952.2 1015274 1015867 R Weakly similar to Oryctolagus cuniculus (rabbit) glutathione S-transferase SW:GTC_RABIT (Q08862) (220 aa) fasta scores: E(): 8.5, 27.381% id in 168 aa. Similar to Lactococcus lactis hypothetical protein YdgF TR:Q9CIJ7 (EMBL:AE006273) (197 aa) fasta scores: E(): 2e-16, 37.500% id in 192 aa; hypothetical protein complement(1015274..1015867) Staphylococcus aureus subsp. aureus MRSA252 2859441 YP_040391.1 CDS SAR0972 NC_002952.2 1016053 1016400 D Similar to Bacillus halodurans hypothetical protein BH2850 TR:Q9K902 (EMBL:AP001516) (126 aa) fasta scores: E(): 1.1e-09, 36.134% id in 119 aa, and to Bacillus subtilis hypothetical protein YjbL TR:O31610 (EMBL:Z99110) (122 aa) fasta scores: E(): 1.4e-09, 36.441% id in 118 aa; hypothetical protein 1016053..1016400 Staphylococcus aureus subsp. aureus MRSA252 2859442 YP_040392.1 CDS SAR0973 NC_002952.2 1016417 1017052 D Similar to an internal region of Vibrio sp GTP pyrophosphokinase RelA SW:RELA_VIBSS (P55133) (744 aa) fasta scores: E(): 0.0063, 27.545% id in 167 aa, and to full length Bacillus halodurans GTP pyrophosphokinase BH2849 TR:Q9K903 (EMBL:AP001516) (211 aa) fasta scores: E(): 2.2e-49, 62.621% id in 206 aa; GTP pyrophosphokinase 1016417..1017052 Staphylococcus aureus subsp. aureus MRSA252 2859443 YP_040393.1 CDS ppnK NC_002952.2 1017069 1017878 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1017069..1017878 Staphylococcus aureus subsp. aureus MRSA252 2859444 YP_040394.1 CDS SAR0975 NC_002952.2 1017875 1018729 D Similar to Bacillus subtilis hypothetical protein YjbO SW:YJBO_BACSU (O31613) (283 aa) fasta scores: E(): 6e-32, 36.525% id in 282 aa, and to Bacillus halodurans hypothetical protein BH2847 TR:Q9K905 (EMBL:AP001516) (302 aa) fasta scores: E(): 1.1e-30, 35.836% id in 293 aa; RNA pseudouridylate synthase 1017875..1018729 Staphylococcus aureus subsp. aureus MRSA252 2859445 YP_040395.1 CDS SAR0976 NC_002952.2 1018750 1020135 D Similar to Bacillus halodurans magnesium transporter BH0511 TR:Q9KFG8 (EMBL:AP001508) (452 aa) fasta scores: E(): 9.9e-61, 39.367% id in 442 aa, and to Bacillus subtilis hypothetical protein YkoK TR:O34442 (EMBL:AJ002571) (451 aa) fasta scores: E(): 1.6e-57, 38.462% id in 455 aa; divalent cation transport protein 1018750..1020135 Staphylococcus aureus subsp. aureus MRSA252 2859446 YP_040396.1 CDS SAR0977 NC_002952.2 1020145 1021989 D N-terminal region is similar to Enterococcus hirae Na+/H+ antiporter protein NapA SW:NAPA_ENTHR (P26235) (383 aa) fasta scores: E(): 3.8e-10, 26.368% id in 402 aa. Full length CDS is similar to and to Bacillus subtilis hypothetical protein YjbQ TR:O31615 (EMBL:Z99110) (614 aa) fasta scores: E(): 2.9e-108, 52.545% id in 609 aa; cation transport protein 1020145..1021989 Staphylococcus aureus subsp. aureus MRSA252 2859447 YP_040397.1 CDS fabI NC_002952.2 1022267 1023037 D Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 1022267..1023037 Staphylococcus aureus subsp. aureus MRSA252 2859621 YP_040398.1 CDS SAR0979 NC_002952.2 1023233 1024318 R Similar to Bacillus halodurans hypothetical protein BH2921 TR:Q9K8T1 (EMBL:AP001517) (361 aa) fasta scores: E(): 4.4e-33, 34.795% id in 365 aa, and to Bacillus subtilis hypothetical protein YueF SW:YUEF_BACSU (O32095) (369 aa) fasta scores: E(): 5.1e-33, 35.556% id in 360 aa; hypothetical protein complement(1023233..1024318) Staphylococcus aureus subsp. aureus MRSA252 2859448 YP_040399.1 CDS SAR0980 NC_002952.2 1024660 1026228 D Similar to thermophilic Bacillus sp PS3 sodium/proton-dependent alanine carrier protein Acp SW:ALCP_BACP3 (P30145) (445 aa) fasta scores: E(): 3.9e-51, 48.017% id in 479 aa, and to Bacillus subtilis hypothetical protein YrbD TR:O32060 (EMBL:Z99118) (484 aa) fasta scores: E(): 1.8e-70, 54.617% id in 509 aa. Possible alternative translational start site; sodium:alanine symporter family protein 1024660..1026228 Staphylococcus aureus subsp. aureus MRSA252 2859449 YP_040400.1 CDS SAR0981 NC_002952.2 1026371 1027129 D Similar to Bacillus halodurans hypothetical protein BH1440 TR:Q9KCX9 (EMBL:AP001512) (242 aa) fasta scores: E(): 2e-35, 41.975% id in 243 aa, and to Bacillus subtilis hypothetical protein YjcH TR:O31630 (EMBL:Z99110) (240 aa) fasta scores: E(): 5.8e-35, 39.316% id in 234 aa; hypothetical protein 1026371..1027129 Staphylococcus aureus subsp. aureus MRSA252 2859450 YP_040401.1 CDS SAR0982 NC_002952.2 1027295 1028020 D Poor database matches. Similar an internal region of Lactococcus lactis restriction-modification system protein AbiM TR:P71445 (EMBL:X97263) (580 aa) fasta scores: E(): 4, 24.255% id in 235 aa; hypothetical protein 1027295..1028020 Staphylococcus aureus subsp. aureus MRSA252 2859451 YP_040402.1 CDS SAR0983 NC_002952.2 1028022 1028873 D Poor database matches. Similar to Bacillus cereus DNA alkylation repair enzyme Alk1 TR:Q9XBJ4 (EMBL:AJ010139) (287 aa) fasta scores: E(): 0.00011, 22.868% id in 258 aa; hypothetical protein 1028022..1028873 Staphylococcus aureus subsp. aureus MRSA252 2859452 YP_040403.1 CDS SAR0985 NC_002952.2 1029615 1030124 D similar to 2'-5' RNA ligase; hypothetical protein 1029615..1030124 Staphylococcus aureus subsp. aureus MRSA252 2859454 YP_040404.1 CDS SAR0986 NC_002952.2 1030237 1031427 R Similar to Bacillus halodurans hypothetical protein BH2311 TR:Q9KAH6 (EMBL:AP001515) (391 aa) fasta scores: E(): 1.4e-08, 25.000% id in 400 aa, and to Escherichia coli hypothetical protein YceE SW:YCEE_ECOLI (P25744) (408 aa) fasta scores: E(): 1.1e-07, 24.422% id in 389 aa; hypothetical protein complement(1030237..1031427) Staphylococcus aureus subsp. aureus MRSA252 2861139 YP_040405.1 CDS SAR0987 NC_002952.2 1031405 1032580 R processive; catalyzes the formation of mono-, di- and tri-glucosyldiacylglycerol by the progressive transfer of glucosyl residues to diacylglycerol; involved in the formation of membrane glycolipids; diacylglycerol glucosyltransferase complement(1031405..1032580) Staphylococcus aureus subsp. aureus MRSA252 2861140 YP_040406.1 CDS murE NC_002952.2 1033012 1034496 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1033012..1034496 Staphylococcus aureus subsp. aureus MRSA252 2861323 YP_040407.1 CDS SAR0989 NC_002952.2 1034486 1034737 D Poor database matches. Similar to Bacillus subtilis hypothetical protein YueH TR:O32093 (EMBL:Z99120) (82 aa) fasta scores: E(): 1.5, 26.866% id in 67 aa; hypothetical protein 1034486..1034737 Staphylococcus aureus subsp. aureus MRSA252 2861141 YP_040408.1 CDS prfC NC_002952.2 1034737 1036299 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 1034737..1036299 Staphylococcus aureus subsp. aureus MRSA252 2860150 YP_040409.1 CDS SAR0991 NC_002952.2 1036601 1037404 D Similar to Bacillus halodurans hypothetical protein BH2553 TR:Q9K9U2 (EMBL:AP001515) (265 aa) fasta scores: E(): 2.4e-48, 53.640% id in 261 aa, and to Bacillus megaterium hypothetical protein YkoY TR:Q9ZF98 (EMBL:AF109909) (271 aa) fasta scores: E(): 5.2e-31, 57.414% id in 263 aa; hypothetical protein 1036601..1037404 Staphylococcus aureus subsp. aureus MRSA252 2861142 YP_040410.1 CDS SAR0992 NC_002952.2 1037638 1039947 D C-terminus is similar to Bacillus subtilis hypothetical protease YyxA SW:YYXA_BACSU (P39668) (400 aa) fasta scores: E(): 1.2e-29, 34.332% id in 367 aa, and to Streptococcus pneumoniae serine protease TR:O06670 (EMBL:AF000658) (397 aa) fasta scores: E(): 5.6e-27, 35.143% id in 350 aa; protease 1037638..1039947 Staphylococcus aureus subsp. aureus MRSA252 2861143 YP_040411.1 CDS SAR0993 NC_002952.2 1039964 1041322 D Similar to Enterococcus hirae vacuolar-type sodium ATP synthase subunit J NtpJ SW:NTPJ_ENTHR (P43440) (451 aa) fasta scores: E(): 1.4e-40, 31.858% id in 452 aa, and to Bacillus subtilis hypothetical protein YkrM TR:O31658 (EMBL:Z99111) (449 aa) fasta scores: E(): 2.3e-83, 50.222% id in 450 aa; sodium transport protein 1039964..1041322 Staphylococcus aureus subsp. aureus MRSA252 2861144 YP_040412.1 CDS SAR0994 NC_002952.2 1041458 1042972 D Poor database matches. Similar to Lactococcus lactis phosphatase YcjM TR:Q9CIQ3 (EMBL:AE006267) (519 aa) fasta scores: E(): 8.6e-16, 22.960% id in 527 aa, and to Helicobacter pylori 2',3'-cyclic-nucleotide 2'-phosphodiesterase HP0104 TR:O24930 (EMBL:AE000532) (581 aa) fasta scores: E(): 7.6e-14, 22.701% id in 511 aa; 5'-nucleotidase 1041458..1042972 Staphylococcus aureus subsp. aureus MRSA252 2861145 YP_040413.1 CDS SAR0995 NC_002952.2 1043461 1044030 R Similar to Bacillus subtilis competence transcription factor ComK SW:COMK_BACSU (P40396) (192 aa) fasta scores: E(): 5.4e-10, 29.487% id in 156 aa, and to Listeria monocytogenes competence transcription factor ComK TR:Q9RP24 (EMBL:AF174588) (190 aa) fasta scores: E(): 1.8e-09, 27.439% id in 164 aa; regulatory protein complement(1043461..1044030) Staphylococcus aureus subsp. aureus MRSA252 2861146 YP_040414.1 CDS SAR0996 NC_002952.2 1044231 1044458 D Poor database matches. Similar to Bacillus subtilis hypothetical protein YhzC TR:O31594 (EMBL:Z99109) (77 aa) fasta scores: E(): 1.3, 32.836% id in 67 aa; hypothetical protein 1044231..1044458 Staphylococcus aureus subsp. aureus MRSA252 2861147 YP_040415.1 CDS SAR0997 NC_002952.2 1044539 1045525 R Similar to Escherichia coli lipoate-protein ligase A LplA SW:LPLA_ECOLI (P32099) (337 aa) fasta scores: E(): 3.4e-30, 34.323% id in 303 aa, and to Bacillus subtilis hypothetical protein YhfJ TR:O07608 (EMBL:Y14083) (331 aa) fasta scores: E(): 4.8e-70, 56.970% id in 330 aa; lipoate-protein ligase A complement(1044539..1045525) Staphylococcus aureus subsp. aureus MRSA252 2861148 YP_040416.1 CDS SAR0998 NC_002952.2 1045724 1045900 D Poor database matches. Similar to C-terminal region of Bacillus subtilis hypothetical protein YkvS TR:O31684 (EMBL:Z99111) (143 aa) fasta scores: E(): 1.6e-11, 61.818% id in 55 aa. Possible gene remnant; hypothetical protein 1045724..1045900 Staphylococcus aureus subsp. aureus MRSA252 2861149 YP_040417.1 CDS SAR0999 NC_002952.2 1045915 1046517 D Poor database matches. Similar to Thermotoga maritima hypothetical protein TT1529 TR:Q9X1L5 (EMBL:AE001800) (208 aa) fasta scores: E(): 0.018, 23.858% id in 197 aa; hypothetical protein 1045915..1046517 Staphylococcus aureus subsp. aureus MRSA252 2861150 YP_040418.1 CDS SAR1000 NC_002952.2 1046697 1046876 D Poor database matches. Similar to Centruroides noxius toxin Cn10 precursor CngTIX TR:Q94435 (EMBL:Y08270) (81 aa) fasta scores: E(): 3.2, 34.043% id in 47 aa. Doubtful CDS; hypothetical protein 1046697..1046876 Staphylococcus aureus subsp. aureus MRSA252 2861151 YP_040419.1 CDS SAR1001 NC_002952.2 <1047536 1047817 D Poor database matches. Similar to Lactococcus lactis lactococcin 972 precursor LclA TR:O86283 (EMBL:AJ002203) (91 aa) fasta scores: E(): 0.003, 34.884% id in 86 aa; hypothetical protein <1047536..1047817 Staphylococcus aureus subsp. aureus MRSA252 2859062 YP_040420.1 CDS SAR1002 NC_002952.2 1047861 1049825 D Poor database matches. Similar to Lactococcus lactis hypothetical protein YujE TR:Q9CE29 (EMBL:AE006431) (660 aa) fasta scores: E(): 3.8e-11, 19.062% id in 661 aa; hypothetical protein 1047861..1049825 Staphylococcus aureus subsp. aureus MRSA252 2861559 YP_040421.1 CDS SAR1003 NC_002952.2 1049828 1050148 D Poor database matches. Similar to Bacillus subtilis hypothetical protein YxeA SW:YXEA_BACSU (P54940) (115 aa) fasta scores: E(): 0.0055, 28.448% id in 116 aa; hypothetical protein 1049828..1050148 Staphylococcus aureus subsp. aureus MRSA252 2861560 YP_040422.1 CDS SAR1004 NC_002952.2 1050145 1050786 D Similar to Streptococcus pneumoniae hypothetical protein TR:Q9ZHB1 (EMBL:AF068902) (213 aa) fasta scores: E(): 1.6e-25, 47.317% id in 205 aa, and to Lactococcus lactis hypothetical ATP binding protein TR:Q9L650 (EMBL:AF242367) (207 aa) fasta scores: E(): 7e-24, 42.995% id in 207 aa; ABC transporter ATP-binding protein 1050145..1050786 Staphylococcus aureus subsp. aureus MRSA252 2861561 YP_040423.1 CDS SAR1005 NC_002952.2 1050874 1051164 R Poor database matches. Similar to the N-terminal region of Campylobacter jejuni flagellar biosynthesis protein CJ0882 TR:Q9PP48 (EMBL:AL139076) (724 aa) fasta scores: E(): 9.7, 28.395% id in 81 aa. Doubtful CDS; hypothetical protein complement(1050874..1051164) Staphylococcus aureus subsp. aureus MRSA252 2861562 YP_040424.1 CDS SAR1006 NC_002952.2 1051201 1051308 D No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein 1051201..1051308 Staphylococcus aureus subsp. aureus MRSA252 2861563 YP_040425.1 CDS SAR1007 NC_002952.2 1051505 1051792 D hypothetical protein 1051505..1051792 Staphylococcus aureus subsp. aureus MRSA252 2861564 YP_040426.1 CDS SAR1010 NC_002952.2 1053367 1053723 R Similar to Bacillus halodurans hypothetical protein BH3304 TR:Q9RC47 (EMBL:AB024562) (129 aa) fasta scores: E(): 1.1e-10, 36.893% id in 103 aa, and to Bacillus subtilis hypothetical protein YfiD SW:YFID_BACSU (P54720) (134 aa) fasta scores: E(): 1.5e-08, 33.333% id in 102 aa; hypothetical protein complement(1053367..1053723) Staphylococcus aureus subsp. aureus MRSA252 2861566 YP_040427.1 CDS SAR1011 NC_002952.2 1054214 1055173 D Similar to Escherichia coli citrate-dependent iron transport, periplasmic protein FecB SW:FECB_ECOLI (P15028) (300 aa) fasta scores: E(): 2e-22, 38.652% id in 282 aa, and to Bacillus subtilis hypothetical protein YfmC TR:O34348 (EMBL:Z99108) (315 aa) fasta scores: E(): 3.3e-24, 38.390% id in 323 aa; transport system extracellular binding lipoprotein 1054214..1055173 Staphylococcus aureus subsp. aureus MRSA252 2861567 YP_040428.1 CDS SAR1012 NC_002952.2 1055220 1055336 R hypothetical protein complement(1055220..1055336) Staphylococcus aureus subsp. aureus MRSA252 2861568 YP_040429.1 CDS SAR1013 NC_002952.2 1055415 1055630 R Poor database matches. Similar to Lactococcus lactis hypothetical protein YafF TR:Q9CJE6 (EMBL:AE006243) (80 aa) fasta scores: E(): 0.031, 32.812% id in 64 aa. C-terminus is similar to the C-terminal region of SAR1190, 58.209% identity (59.091% ungapped) in 67 aa overlap; hypothetical protein complement(1055415..1055630) Staphylococcus aureus subsp. aureus MRSA252 2861569 YP_040430.1 CDS SAR1014 NC_002952.2 1055795 1056346 D Poor database matches. Similar to Bacillus halodurans hypothetical protein BH2104 TR:Q9KB31 (EMBL:AP001514) (203 aa) fasta scores: E(): 0.005, 26.087% id in 184 aa, and to Deinococcus radiodurans hypothetical protein DR0797 TR:Q9RW72 (EMBL:AE001934) (158 aa) fasta scores: E(): 0.00012, 28.358% id in 134 aa; hypothetical protein 1055795..1056346 Staphylococcus aureus subsp. aureus MRSA252 2861570 YP_040431.1 CDS SAR1015 NC_002952.2 1056398 1057336 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(1056398..1057336) Staphylococcus aureus subsp. aureus MRSA252 2861571 YP_040432.1 CDS SAR1016 NC_002952.2 1057509 1058879 D C-terminus is similar to the C-terminal regions of Escherichia coli isochorismate synthase EntC SW:ENTC_ECOLI (P10377) (391 aa) fasta scores: E(): 2.7e-18, 29.391% id in 279 aa, and Bacillus subtilis menaquinone-specific isochorismate synthase MenF SW:MENF_BACSU (P23973) (471 aa) fasta scores: E(): 5.4e-38, 34.562% id in 434 aa. Possible alternative translational start site; chorismate binding protein 1057509..1058879 Staphylococcus aureus subsp. aureus MRSA252 2861572 YP_040433.1 CDS SAR1017 NC_002952.2 1058866 1060539 D Similar to Escherichia coli menaquinone biosynthesis bifunctional protein [includes: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase and alpha-ketoglutarate decarboxylase] MenD SW:MEND_ECOLI (P17109) (556 aa) fasta scores: E(): 4.5e-38, 29.107% id in 560 aa, and to Bacillus subtilis menaquinone biosynthesis bifunctional protein [includes: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase and alpha-ketoglutarate decarboxylase] MenD SW:MEND_BACSU (P23970) (580 aa) fasta scores: E(): 7.8e-34, 39.478% id in 575 aa; menaquinone biosynthesis bifunctional protein 1058866..1060539 Staphylococcus aureus subsp. aureus MRSA252 2861573 YP_040434.1 CDS SAR1018 NC_002952.2 1060526 1061329 D Similar to Rhodococcus sp 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BpdF TR:Q52897 (EMBL:U44891) (297 aa) fasta scores: E(): 2.5e-08, 25.806% id in 279 aa, and to Bacillus subtilis hypothetical protein YtxM TR:O34312 (EMBL:AF008220) (274 aa) fasta scores: E(): 1.9e-27, 34.749% id in 259 aa. CDS is truncated at the N-terminus in comparison to the Rhodococcus sp protein; hydrolase 1060526..1061329 Staphylococcus aureus subsp. aureus MRSA252 2861574 YP_040435.1 CDS menB NC_002952.2 1061322 1062143 D catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 1061322..1062143 Staphylococcus aureus subsp. aureus MRSA252 2861160 YP_040436.1 CDS sspC NC_002952.2 1062379 1062708 R Similar to an internal region of Clostridium botulinum main hemagglutinin component HA-33 SW:HA33_CLOBO (P46084) (285 aa) fasta scores: E(): 2.3, 25.743% id in 101 aa. Previously sequenced as Staphylococcus aureus serine protease (ssp) operon hypothetical protein SspC TR:Q9EYW6 (EMBL:AF309515) (109 aa) fasta scores: E(): 2.8e-44, 99.083% id in 109 aa; hypothetical protein complement(1062379..1062708) Staphylococcus aureus subsp. aureus MRSA252 2859508 YP_040437.1 CDS sspB NC_002952.2 1062746 1063927 R Previously sequenced as Staphylococcus aureus cysteine protease preproprotein SspB TR:Q9EYW7 (EMBL:AF309515) (393 aa) fasta scores: E(): 6.4e-137, 97.710% id in 393 aa; cysteine protease precursor complement(1062746..1063927) Staphylococcus aureus subsp. aureus MRSA252 2859507 YP_040438.1 CDS sspA NC_002952.2 1064009 1065082 R Almost identical to Staphylococcus aureus glutamyl endopeptidase precursor TR:Q04186 (EMBL:D00730) (357 aa) fasta scores: E(): 5e-126, 99.440% id in 357 aa. Highly similar to Staphylococcus aureus serine protease (ssp) operon V8 protease SspA TR:AAG45843 (EMBL:AF309515) (336 aa) fasta scores: E(): 1.2e-110, 91.317% id in 357 aa. CDS contains a C-terminus repeat region (D/NNP x19), residues 287 to 343. CDS contains extra residues (21) in this repeat region relative to the SspA V8 protease. N-terminus is similar to Staphylococcus warneri glutamyl endopeptidase ProM TR:Q9FBG1 (EMBL:AJ293885) (316 aa) fasta scores: E(): 2.8e-75, 71.069% id in 318 aa; glutamyl endopeptidase precursor complement(1064009..1065082) Staphylococcus aureus subsp. aureus MRSA252 2859506 YP_040439.1 CDS SAR1023 NC_002952.2 1065610 1066764 R Similar to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) (393 aa) fasta scores: E(): 1.8e-40, 35.967% id in 367 aa, and to Bacillus subtilis aminotransferase A PatA SW:PATA_BACSU (P16524) (392 aa) fasta scores: E(): 3.5e-62, 45.195% id in 385 aa; aminotransferase complement(1065610..1066764) Staphylococcus aureus subsp. aureus MRSA252 2861575 YP_040440.1 CDS SAR1025 NC_002952.2 1068123 1068542 D Similar to Escherichia coli transcriptional regulator SlyA SW:SLYA_ECOLI (P55740) (146 aa) fasta scores: E(): 0.058, 31.724% id in 145 aa, and to Staphylococcus epidermidis transcriptional regulator AtlR TR:O33636 (EMBL:U71377) (139 aa) fasta scores: E(): 2.6e-41, 87.591% id in 137 aa; MarR family regulatory protein 1068123..1068542 Staphylococcus aureus subsp. aureus MRSA252 2861577 YP_040441.1 CDS atl NC_002952.2 1068750 1072523 R Highly similar to Staphylococcus aureus bifunctional autolysin precursor [includes: N-acetylmuramoyl-L-alanine amidase and endo-beta-N-acetylglucosaminidase] Atl SW:ATL_STAAU (P52081) (1256 aa) fasta scores: E(): 0, 97.538% id in 1259 aa. Similar to Staphylococcus epidermidis autolysin AtlE TR:O33635 (EMBL:U71377) (1335 aa) fasta scores: E(): 5.7e-102, 59.808% id in 1356 aa; bifunctional autolysin precursor complement(1068750..1072523) Staphylococcus aureus subsp. aureus MRSA252 2859873 YP_040442.1 CDS SAR1027 NC_002952.2 1072751 1073185 R Similar to Staphylococcus epidermidis hypothetical protein TR:O33634 (EMBL:U71377) (140 aa) fasta scores: E(): 3.2e-25, 55.000% id in 140 aa, and to Bacillus halodurans hypothetical protein BH1438 TR:Q9KCY1 (EMBL:AP001512) (144 aa) fasta scores: E(): 8.8e-21, 46.667% id in 135 aa; acetyltransferase (GNAT) family protein complement(1072751..1073185) Staphylococcus aureus subsp. aureus MRSA252 2861578 YP_040443.1 CDS SAR1028 NC_002952.2 1073341 1073811 R Poor database matches. Similar to Staphylococcus epidermidis autolysin hypothetical protein TR:O33633 (EMBL:U71377) (156 aa) fasta scores: E(): 4e-57, 87.179% id in 156 aa; hypothetical protein complement(1073341..1073811) Staphylococcus aureus subsp. aureus MRSA252 2861579 YP_040444.1 CDS SAR1029 NC_002952.2 1073859 1075085 R N-terminal region is similar to Bacillus subtilis membrane-bound attenuator of the expression of both lytABC and lytR operons, LytR SW:LYTR_BACSU (Q02115) (306 aa) fasta scores: E(): 3.3e-22, 32.484% id in 314 aa, and to Bacillus halodurans transcriptional regulator BH3647 TR:Q9K6S9 (EMBL:AP001519) (359 aa) fasta scores: E(): 4e-32, 37.730% id in 326 aa; hypothetical protein complement(1073859..1075085) Staphylococcus aureus subsp. aureus MRSA252 2860777 YP_040445.1 CDS fmt NC_002952.2 1075526 1076719 D Similar to Staphylococcus aureus autolysis and methicillin resistant-related protein Fmt TR:O50608 (EMBL:AB009635) (397 aa) fasta scores: E(): 5.6e-140, 93.451% id in 397 aa, and to Bacillus subtilis penicillin-binding protein PbpX TR:O31773 (EMBL:Z99112) (391 aa) fasta scores: E(): 8.6e-25, 29.381% id in 388 aa; autolysis and methicillin resistant-related protein 1075526..1076719 Staphylococcus aureus subsp. aureus MRSA252 2860671 YP_040446.1 CDS qoxD NC_002952.2 1077062 1077352 R Similar to Bacillus subtilis quinol oxidase polypeptide IV QoxD SW:QOX4_BACSU (P34959) (123 aa) fasta scores: E(): 8.2e-15, 52.688% id in 93 aa, and to Bacillus halodurans cytochrome aa3 quinol oxidase subunit IV BH2067 TR:Q9KB64 (EMBL:AP001514) (136 aa) fasta scores: E(): 2.8e-11, 47.674% id in 86 aa; quinol oxidase polypeptide IV complement(1077062..1077352) Staphylococcus aureus subsp. aureus MRSA252 2859295 YP_040447.1 CDS qoxC NC_002952.2 1077349 1077954 R Similar to Bacillus subtilis quinol oxidase polypeptide III QoxC SW:QOX3_BACSU (P34958) (204 aa) fasta scores: E(): 1.3e-38, 54.211% id in 190 aa, and to Bacillus halodurans cytochrome aa3 quinol oxidase subunit III BH2066 TR:Q9KB65 (EMBL:AP001514) (204 aa) fasta scores: E(): 3e-39, 56.316% id in 190 aa; quinol oxidase polypeptide III complement(1077349..1077954) Staphylococcus aureus subsp. aureus MRSA252 2859294 YP_040448.1 CDS qoxB NC_002952.2 1077944 1079932 R Similar to Bacillus subtilis quinol oxidase polypeptide I QoxB SW:QOX1_BACSU (P34956) (649 aa) fasta scores: E(): 1.7e-163, 62.154% id in 650 aa, and to Bacillus halodurans cytochrome aa3 quinol oxidase subunit I BH2065 TR:Q9KB66 (EMBL:AP001514) (647 aa) fasta scores: E(): 5.2e-160, 63.060% id in 647 aa; quinol oxidase polypeptide I complement(1077944..1079932) Staphylococcus aureus subsp. aureus MRSA252 2859293 YP_040449.1 CDS qoxA NC_002952.2 1079932 1081032 R Similar to Bacillus subtilis quinol oxidase polypeptide II precursor QoxA SW:QOX2_BACSU (P34957) (322 aa) fasta scores: E(): 1.5e-47, 45.333% id in 300 aa, and to Bacillus halodurans cytochrome aa3 quinol oxidase subunit II BH2064 TR:Q9RC66 (EMBL:AB024557) (329 aa) fasta scores: E(): 5.5e-35, 38.871% id in 319 aa. CDS is extended at the C-terminus in comparison to Bacillus subtilis and Bacillus halodurans othologues; quinol oxidase polypeptide II precursor complement(1079932..1081032) Staphylococcus aureus subsp. aureus MRSA252 2859292 YP_040450.1 CDS SAR1035 NC_002952.2 1081604 1081921 R hypothetical protein complement(1081604..1081921) Staphylococcus aureus subsp. aureus MRSA252 2860778 YP_040451.1 CDS folD NC_002952.2 1082761 1083621 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(1082761..1083621) Staphylococcus aureus subsp. aureus MRSA252 2860677 YP_040452.1 CDS purE NC_002952.2 1083822 1084304 D Similar to Bacillus subtilis phosphoribosylaminoimidazole carboxylase catalytic subunit PurE SW:PUR6_BACSU (P12044) (162 aa) fasta scores: E(): 6.1e-32, 60.510% id in 157 aa, and to Aquifex aeolicus phosphoribosylaminoimidazole carboxylase catalytic subunit PurE SW:PUR6_AQUAE (O67239) (167 aa) fasta scores: E(): 7.5e-31, 62.025% id in 158 aa; phosphoribosylaminoimidazole carboxylase catalytic subunit 1083822..1084304 Staphylococcus aureus subsp. aureus MRSA252 2859545 YP_040453.1 CDS purK NC_002952.2 1084291 1085415 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1084291..1085415 Staphylococcus aureus subsp. aureus MRSA252 2859548 YP_040454.1 CDS purC NC_002952.2 1085419 1086123 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 1085419..1086123 Staphylococcus aureus subsp. aureus MRSA252 2860160 YP_040455.1 CDS SAR1041 NC_002952.2 1086123 1086386 D Similar to Bacillus subtilis hypothetical protein YexA SW:YEXA_BACSU (P12049) (84 aa) fasta scores: E(): 5.6e-09, 38.272% id in 81 aa, and to Bacillus halodurans hypothetical protein BH0627 TR:Q9KF59 (EMBL:AP001509) (84 aa) fasta scores: E(): 3.8e-08, 36.905% id in 84 aa; hypothetical protein 1086123..1086386 Staphylococcus aureus subsp. aureus MRSA252 2860779 YP_040456.1 CDS purQ NC_002952.2 1086388 1087059 D catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 1086388..1087059 Staphylococcus aureus subsp. aureus MRSA252 2859552 YP_040457.1 CDS purL NC_002952.2 1087052 1089241 D catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 1087052..1089241 Staphylococcus aureus subsp. aureus MRSA252 2859549 YP_040458.1 CDS purF NC_002952.2 1089220 1090704 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1089220..1090704 Staphylococcus aureus subsp. aureus MRSA252 2859546 YP_040459.1 CDS purM NC_002952.2 1090697 1091725 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 1090697..1091725 Staphylococcus aureus subsp. aureus MRSA252 2859550 YP_040460.1 CDS purN NC_002952.2 1091728 1092294 D Similar to Bacillus subtilis phosphoribosylglycinamide formyltransferase PurN SW:PUR3_BACSU (P12040) (195 aa) fasta scores: E(): 1.5e-29, 49.735% id in 189 aa, and to Bacillus halodurans phosphoribosylglycinamide formyltransferase BH0632 TR:Q9KF54 (EMBL:AP001509) (188 aa) fasta scores: E(): 1.1e-29, 47.059% id in 187 aa; phosphoribosylglycinamide formyltransferase 1091728..1092294 Staphylococcus aureus subsp. aureus MRSA252 2859551 YP_040461.1 CDS purH NC_002952.2 1092309 1093787 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1092309..1093787 Staphylococcus aureus subsp. aureus MRSA252 2859547 YP_040462.1 CDS purD NC_002952.2 1093809 1095056 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1093809..1095056 Staphylococcus aureus subsp. aureus MRSA252 2859544 YP_040463.1 CDS SAR1049 NC_002952.2 1095324 1096145 R Similar to Lactobacillus helveticus proline iminopeptidase PepI TR:Q48561 (EMBL:Z56283) (217 aa) fasta scores: E(): 0.00045, 25.751% id in 233 aa, and to Bacillus subtilis hypothetical protein YkoC TR:O34572 (EMBL:AJ002571) (254 aa) fasta scores: E(): 4.5e-10, 24.336% id in 226 aa; cobalt transport protein complement(1095324..1096145) Staphylococcus aureus subsp. aureus MRSA252 2860780 YP_040464.1 CDS SAR1050 NC_002952.2 1096123 1097523 R Similar to Methanobacterium thermoautotrophicum methyl coenzyme M reductase system, component A2 homologue MTH454 TR:O26554 (EMBL:AE000829) (480 aa) fasta scores: E(): 3.7e-16, 27.696% id in 473 aa, and to Streptococcus pyogenes ABC transporter SPY1787 TR:Q99YA9 (EMBL:AE006606) (464 aa) fasta scores: E(): 2.9e-14, 25.747% id in 435 aa; ABC transporter ATP-binding protein complement(1096123..1097523) Staphylococcus aureus subsp. aureus MRSA252 2860781 YP_040465.1 CDS SAR1051 NC_002952.2 1097538 1098113 R Poor database matches. Similar to Bacillus subtilis hypothetical protein YkoE TR:O34738 (EMBL:AJ002571) (199 aa) fasta scores: E(): 1.4e-13, 36.313% id in 179 aa; hypothetical protein complement(1097538..1098113) Staphylococcus aureus subsp. aureus MRSA252 2860782 YP_040466.1 CDS SAR1052 NC_002952.2 1098697 1098831 R hypothetical protein complement(1098697..1098831) Staphylococcus aureus subsp. aureus MRSA252 2860783 YP_040467.1 CDS SAR1053 NC_002952.2 1098983 1100278 D Poor database matches. N-terminal region is similar to Methanococcus jannaschii hypothetical protein MJ0923 SW:Y923_METJA (Q58333) (297 aa) fasta scores: E(): 3.4, 20.328% id in 305 aa, and C-terminal region is similar to Staphylococcus xylosus hypothetical protein fragment TR:Q9EYR2 (EMBL:AF316496) (199 aa) fasta scores: E(): 9.7e-46, 69.231% id in 195 aa; hypothetical protein 1098983..1100278 Staphylococcus aureus subsp. aureus MRSA252 2860784 YP_040468.1 CDS SAR1054 NC_002952.2 1100703 1101875 D Similar to Staphylococcus xylosus hypothetical protein TR:Q9EYR1 (EMBL:AF316496) (389 aa) fasta scores: E(): 4.8e-114, 72.564% id in 390 aa, and to Bacillus subtilis hypothetical protein YwbD SW:YWBD_BACSU (P39587) (396 aa) fasta scores: E(): 6.1e-67, 48.346% id in 393 aa; hypothetical protein 1100703..1101875 Staphylococcus aureus subsp. aureus MRSA252 2860785 YP_040469.1 CDS SAR1055 NC_002952.2 1101929 1102471 D Poor database matches. Similar to Staphylococcus xylosus hypothetical protein TR:Q9EYR0 (EMBL:AF316496) (180 aa) fasta scores: E(): 2e-48, 70.000% id in 180 aa; hypothetical protein 1101929..1102471 Staphylococcus aureus subsp. aureus MRSA252 2860786 YP_040470.1 CDS ptsH NC_002952.2 1102625 1102891 D Previously sequenced as Staphylococcus aureus histidine-containing phosphocarrier protein (HPr) PtsH SW:PTHP_STAAU (P02907) (88 aa) fasta scores: E(): 8.1e-31, 100.000% id in 88 aa. Similar to Staphylococcus carnosus histidine-containing phosphocarrier protein PtsH SW:PTHP_STACA (P23534) (88 aa) fasta scores: E(): 3.5e-29, 94.318% id in 88 aa; phosphocarrier protein HPr 1102625..1102891 Staphylococcus aureus subsp. aureus MRSA252 2860156 YP_040471.1 CDS ptsI NC_002952.2 1102894 1104612 D Similar to Staphylococcus carnosus phosphoenolpyruvate-protein phosphotransferase PtsI SW:PT1_STACA (P23533) (574 aa) fasta scores: E(): 4e-170, 80.628% id in 573 aa. Previously sequenced as Staphylococcus aureus phosphoenolpyruvate-protein phosphotransferase PtsI SW:PT1_STAAU (P51183) (572 aa) fasta scores: E(): 7.4e-207, 99.301% id in 572 aa; phosphoenolpyruvate-protein phosphotransferase 1102894..1104612 Staphylococcus aureus subsp. aureus MRSA252 2860157 YP_040472.1 CDS SAR1058 NC_002952.2 1104849 1105082 R Similar to Escherichia coli glutaredoxin 3 GrxC SW:GLR3_ECOLI (P37687) (82 aa) fasta scores: E(): 1.6, 28.788% id in 66 aa, and to Clostridium pasteurianum hypothetical glutaredoxin-like protein in rubredoxin operon SW:YRUB_CLOPA (P23171) (75 aa) fasta scores: E(): 0.018, 31.944% id in 72 aa; glutaredoxin complement(1104849..1105082) Staphylococcus aureus subsp. aureus MRSA252 2860787 YP_040473.1 CDS SAR1059 NC_002952.2 1105280 1106641 D Similar to Rhodobacter sphaeroides quinol oxidase subunit I QxtA TR:O86080 (EMBL:AF084032) (465 aa) fasta scores: E(): 6.9e-42, 32.237% id in 456 aa, and to Bacillus stearothermophilus cytochrome bd-type quinol oxidase subunit I CbaB TR:Q9Z9N1 (EMBL:AB016894) (448 aa) fasta scores: E(): 8.9e-94, 55.531% id in 452 aa; cytochrome ubiquinol oxidase 1105280..1106641 Staphylococcus aureus subsp. aureus MRSA252 2860788 YP_040474.1 CDS SAR1060 NC_002952.2 1106638 1107657 D Similar to Pseudomonas aeruginosa cyanide insensitive terminal oxidase CioB TR:O07441 (EMBL:Y10528) (335 aa) fasta scores: E(): 2.4e-06, 21.951% id in 328 aa, and to Bacillus halodurans cytochrome D ubiquinol oxidase subunit II BH3974 TR:Q9K5W3 (EMBL:AP001520) (338 aa) fasta scores: E(): 4.3e-66, 53.550% id in 338 aa; hypothetical protein 1106638..1107657 Staphylococcus aureus subsp. aureus MRSA252 2860789 YP_040475.1 CDS SAR1061 NC_002952.2 1107790 1108452 D Similar to Bacillus subtilis hypothetical protein YkqB SW:YKQB_BACSU (P39760) (221 aa) fasta scores: E(): 5.6e-51, 64.516% id in 217 aa, and to Bacillus halodurans potassium uptake protein BH2663 TR:Q9K9I4 (EMBL:AP001516) (220 aa) fasta scores: E(): 3.8e-48, 62.212% id in 217 aa; potassium transport protein 1107790..1108452 Staphylococcus aureus subsp. aureus MRSA252 2860790 YP_040476.1 CDS SAR1063 NC_002952.2 1108800 1110497 R Similar to Bacillus halodurans hypothetical protein BH2662 TR:Q9K9I5 (EMBL:AP001516) (555 aa) fasta scores: E(): 1e-154, 67.446% id in 556 aa, and to Bacillus subtilis hypothetical protein YkqC SW:YKQC_BACSU (Q45493) (555 aa) fasta scores: E(): 2e-152, 67.086% id in 556 aa; hypothetical protein complement(1108800..1110497) Staphylococcus aureus subsp. aureus MRSA252 2860791 YP_040477.1 CDS SAR1064 NC_002952.2 1110497 1110715 R Similar to Bacillus halodurans hypothetical protein BH2661 TR:Q9K9I6 (EMBL:AP001516) (69 aa) fasta scores: E(): 8.6e-11, 53.731% id in 67 aa, and to Bacillus subtilis hypothetical protein YkzG R:O31718 (EMBL:Z99111) (69 aa) fasta scores: E(): 3.7e-10, 56.061% id in 66 aa; hypothetical protein complement(1110497..1110715) Staphylococcus aureus subsp. aureus MRSA252 2860792 YP_040478.1 CDS def NC_002952.2 1111197 1111748 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1111197..1111748) Staphylococcus aureus subsp. aureus MRSA252 2860793 YP_040479.1 CDS SAR1066 NC_002952.2 1112113 1112739 D Poor database matches. Similar to Bacillus subtilis hypothetical protein in YkyA SW:YKYA_BACSU (P21884) (237 aa) fasta scores: E(): 7.1e-05, 24.880% id in 209 aa, and to Bacillus subtilis hypothetical protein YkyA TR:Q45496 (EMBL:AF012285) (205 aa) fasta scores: E(): 0.00011, 23.077% id in 195 aa; hypothetical protein 1112113..1112739 Staphylococcus aureus subsp. aureus MRSA252 2860794 YP_040480.1 CDS pdhA NC_002952.2 1112910 1114022 D Similar to Bacillus stearothermophilus pyruvate dehydrogenase E1 component, alpha subunit PdhA SW:ODPA_BACST (P21873) (368 aa) fasta scores: E(): 2.6e-102, 74.931% id in 363 aa, and to Bacillus subtilis pyruvate dehydrogenase E1 component, alpha subunit PdhA SW:ODPA_BACSU (P21881) (370 aa) fasta scores: E(): 2.2e-103, 75.342% id in 365 aa; pyruvate dehydrogenase E1 component subunit alpha 1112910..1114022 Staphylococcus aureus subsp. aureus MRSA252 2859889 YP_040481.1 CDS pdhB NC_002952.2 1114026 1115003 D Similar to Bacillus stearothermophilus pyruvate dehydrogenase E1 component, beta subunit PdhB SW:ODPB_BACST (P21874) (324 aa) fasta scores: E(): 4e-94, 75.926% id in 324 aa, and to Bacillus subtilis pyruvate dehydrogenase E1 component, beta subunit PdhB SW:ODPB_BACSU (P21882) (324 aa) fasta scores: E(): 8.2e-98, 77.469% id in 324 aa; pyruvate dehydrogenase E1 component subunit beta 1114026..1115003 Staphylococcus aureus subsp. aureus MRSA252 2859890 YP_040482.1 CDS pdhC NC_002952.2 1115094 1116386 D Similar to Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_BACST (P11961) (427 aa) fasta scores: E(): 1.6e-102, 70.208% id in 433 aa. Previously sequenced as Staphylococcus aureus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_STAAU (Q59821) (430 aa) fasta scores: E(): 3.7e-148, 99.535% id in 430 aa; branched-chain alpha-keto acid dehydrogenase E2 1115094..1116386 Staphylococcus aureus subsp. aureus MRSA252 2859891 YP_040483.1 CDS pdhD NC_002952.2 1116390 1117796 D E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 1116390..1117796 Staphylococcus aureus subsp. aureus MRSA252 2859892 YP_040484.1 CDS SAR1071 NC_002952.2 1117967 1118242 D Similar to Lactococcus lactis hypothetical protein YfdD TR:Q9CI19 (EMBL:AE006288) (93 aa) fasta scores: E(): 2.8e-13, 51.685% id in 89 aa, and to Bacillus subtilis hypothetical protein YktA TR:Q45497 (EMBL:AF012285) (88 aa) fasta scores: E(): 2.8e-12, 44.828% id in 87 aa; hypothetical protein 1117967..1118242 Staphylococcus aureus subsp. aureus MRSA252 2860795 YP_040485.1 CDS SAR1072 NC_002952.2 1118386 1118925 D Similar to Thermotoga maritima conserved hypothetical protein TM0656 TR:Q9WZC4 (EMBL:AE001739) (176 aa) fasta scores: E(): 3.8e-20, 40.805% id in 174 aa, and to Pseudomonas aeruginosa probable transcriptional regulator PA5301 TR:Q9HTQ3 (EMBL:AE004943) (182 aa) fasta scores: E(): 3e-07, 28.177% id in 181 aa; DNA-binding protein 1118386..1118925 Staphylococcus aureus subsp. aureus MRSA252 2860796 YP_040486.1 CDS SAR1073 NC_002952.2 1118938 1120032 D N-terminus is similar to N-terminal region of Escherichia coli spermidine/putrescine transport ATP-binding protein PotA SW:POTA_ECOLI (P23858) (378 aa) fasta scores: E(): 5.7e-50, 51.736% id in 288 aa. Full length CDS is similar to N-terminal region of Lactococcus lactis spermidine/putrescine ABC transporter ATP-binding protein PotA TR:Q9CGD4 (EMBL:AE006348) (428 aa) fasta scores: E(): 2.3e-78, 62.396% id in 359 aa; ABC transporter ATP-binding protein 1118938..1120032 Staphylococcus aureus subsp. aureus MRSA252 2860797 YP_040487.1 CDS SAR1074 NC_002952.2 1120025 1120822 D Similar to Escherichia coli spermidine/putrescine ABC transporter permease PotB SW:POTB_ECOLI (P23860) (275 aa) fasta scores: E(): 9.8e-21, 29.885% id in 261 aa, and to Lactococcus lactis spermidine/putrescine ABC transporter permease PotB TR:Q9CGD3 (EMBL:AE006348) (262 aa) fasta scores: E(): 7.7e-47, 53.307% id in 257 aa; ABC transporter permease 1120025..1120822 Staphylococcus aureus subsp. aureus MRSA252 2860798 YP_040488.1 CDS SAR1075 NC_002952.2 1120828 1121637 D Similar to Escherichia coli spermidine/putrescine ABC transporter permease PotC SW:POTC_ECOLI (P23859) (264 aa) fasta scores: E(): 9.1e-28, 36.948% id in 249 aa, and to Streptococcus pyogenes spermidine/putrescine ABC transporter PotC TR:Q99ZS6 (EMBL:AE006553) (258 aa) fasta scores: E(): 7.2e-46, 52.756% id in 254 aa; ABC transporter permease 1120828..1121637 Staphylococcus aureus subsp. aureus MRSA252 2860799 YP_040489.1 CDS SAR1076 NC_002952.2 1121637 1122710 D Similar to Escherichia coli spermidine/putrescine-binding periplasmic protein precursor PotD SW:POTD_ECOLI (P23861) (348 aa) fasta scores: E(): 4.6e-43, 38.375% id in 357 aa, and to Streptococcus pyogenes spermidine/putrescine ABC transporter PotD TR:Q99ZS5 (EMBL:AE006553) (357 aa) fasta scores: E(): 3.3e-61, 44.972% id in 358 aa; ABC transporter 1121637..1122710 Staphylococcus aureus subsp. aureus MRSA252 2860800 YP_040490.1 CDS SAR1077 NC_002952.2 1122784 1123803 D hypothetical protein 1122784..1123803 Staphylococcus aureus subsp. aureus MRSA252 2860801 YP_040491.1 CDS SAR1078 NC_002952.2 1124086 1124505 D hypothetical protein 1124086..1124505 Staphylococcus aureus subsp. aureus MRSA252 2860802 YP_040492.1 CDS SAR1079 NC_002952.2 1124587 1125939 R NRAMP (natural resistance-associated macrophage proteins) family protein. Similar to Pseudomonas aeruginosa manganese transport protein MntH1 SW:MNT1_PSEAE (Q9RPF3) (439 aa) fasta scores: E(): 1.7e-63, 44.235% id in 425 aa, and to Lactobacillus brevis manganese transporter HitA TR:BAB47552 (EMBL:AB035808) (464 aa) fasta scores: E(): 3.4e-92, 55.708% id in 438 aa; manganese transport protein MntH complement(1124587..1125939) Staphylococcus aureus subsp. aureus MRSA252 2860803 YP_040493.1 CDS SAR1080 NC_002952.2 1126123 1126737 R Similar to Bacillus subtilis hypothetical protein YktB TR:Q45498 (EMBL:AF012285) (212 aa) fasta scores: E(): 3.9e-28, 41.379% id in 203 aa, and to Bacillus halodurans hypothetical protein BH2637 TR:Q9K9K8 (EMBL:AP001516) (213 aa) fasta scores: E(): 6.9e-27, 38.916% id in 203 aa; hypothetical protein complement(1126123..1126737) Staphylococcus aureus subsp. aureus MRSA252 2860804 YP_040494.1 CDS SAR1081 NC_002952.2 1126894 1127721 D Similar to Lycopersicon esculentum myo-inositol-1 IMP1 SW:MYO1_LYCES (P54926) (273 aa) fasta scores: E(): 6.9e-20, 36.000% id in 225 aa, and to Bacillus subtilis extragenic suppressor protein homologue SuhB SW:SUHB_BACSU (Q45499) (265 aa) fasta scores: E(): 1.6e-46, 49.804% id in 255 aa; inositol monophosphatase 1126894..1127721 Staphylococcus aureus subsp. aureus MRSA252 2860805 YP_040495.1 CDS SAR1082 NC_002952.2 1127875 1128066 R Similar to Bacillus halodurans hypothetical protein BH2633 TR:Q9K9L2 (EMBL:AP001516) (61 aa) fasta scores: E(): 0.03, 31.034% id in 58 aa, and to Bacillus subtilis hypothetical protein YlaF SW:YLAF_BACSU (O07630) (62 aa) fasta scores: E(): 0.66, 31.667% id in 60 aa; hypothetical protein complement(1127875..1128066) Staphylococcus aureus subsp. aureus MRSA252 2861154 YP_040496.1 CDS SAR1083 NC_002952.2 1128168 1130015 D Similar to Escherichia coli GTPase BipA TR:Q9EXN7 (EMBL:AJ278218) (607 aa) fasta scores: E(): 1.6e-118, 53.897% id in 603 aa, and to Bacillus subtilis GTP-binding protein BipA homologue SW:TYPA_BACSU (O07631) (612 aa) fasta scores: E(): 1.6e-171, 77.318% id in 604 aa. In enteropathogenic E. coli (EPEC) BipA undergoes tyrosine phosphorylation and mediates interactions with epithelial cells; BipA family GTPase 1128168..1130015 Staphylococcus aureus subsp. aureus MRSA252 2861245 YP_040497.1 CDS SAR1084 NC_002952.2 1130154 1130321 R Poor database matches. Similar to Bacillus subtilis hypothetical protein YlaI SW:YLAI_BACSU (O07633) (69 aa) fasta scores: E(): 4.2e-05, 45.238% id in 42 aa; hypothetical protein complement(1130154..1130321) Staphylococcus aureus subsp. aureus MRSA252 2861246 YP_040498.1 CDS SAR1085 NC_002952.2 1130323 1130805 R Similar to Bacillus subtilis hypothetical protein YlaL SW:YLAL_BACSU (O07636) (161 aa) fasta scores: E(): 1.4e-10, 31.098% id in 164 aa, and to Bacillus halodurans hypothetical protein BH2628 TR:Q9K9L7 (EMBL:AP001516) (169 aa) fasta scores: E(): 6.5e-10, 33.793% id in 145 aa; hypothetical protein complement(1130323..1130805) Staphylococcus aureus subsp. aureus MRSA252 2861247 YP_040499.1 CDS SAR1086 NC_002952.2 1130946 1131221 D depletion of this protein in Bacillus subtilis results in defects in cell morphology; crystal structure of Staphylococcus protein shows homodimer; ligand binding protein; hypothetical protein 1130946..1131221 Staphylococcus aureus subsp. aureus MRSA252 2861248 YP_040500.1 CDS SAR1087 NC_002952.2 1131535 1132761 D Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cell division protein FtsW or b0089 SWALL:FTSW_ECOLI (SWALL:P16457) (414 aa) fasta scores: E(): 2.5e-31, 32.62% id in 377 aa, and to Enterococcus hirae probable cell division protein FtsW SWALL:FTSW_ENTHR (SWALL:Q47866) (397 aa) fasta scores: E(): 2.8e-40, 36.34% id in 399 aa; cell division protein 1131535..1132761 Staphylococcus aureus subsp. aureus MRSA252 2861249 YP_040501.1 CDS SAR1088 NC_002952.2 1133314 1136766 D biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 1133314..1136766 Staphylococcus aureus subsp. aureus MRSA252 2861250 YP_040502.1 CDS ctaA NC_002952.2 1137034 1137945 R Similar to Bacillus subtilis cytochrome aa3 controlling protein CtaA SW:CTAA_BACSU (P12946) (306 aa) fasta scores: E(): 2.9e-43, 41.883% id in 308 aa. Previously sequenced as Staphylococcus aureus heme A synthase, involved in long-term starvation survival and recovery, CtaA TR:O85704 (EMBL:AF072726) (303 aa) fasta scores: E(): 7.4e-117, 99.670% id in 303 aa; heme A synthase complement(1137034..1137945) Staphylococcus aureus subsp. aureus MRSA252 2859250 YP_040503.1 CDS ctaB NC_002952.2 1138396 1139307 D converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 1138396..1139307 Staphylococcus aureus subsp. aureus MRSA252 2859251 YP_040504.1 CDS SAR1091 NC_002952.2 1139332 1139793 D Poor database matches. Similar to the C-terminal regions of Bacillus subtilis hypothetical protein YozB TR:O31845 (EMBL:Z99114) (178 aa) fasta scores: E(): 1.5e-06, 27.941% id in 136 aa, and to Bradyrhizobium japonicum cytochrome-c oxidase CoxP TR:Q45236 (EMBL:X68547) (240 aa) fasta scores: E(): 1.3, 26.230% id in 122 aa; hypothetical protein 1139332..1139793 Staphylococcus aureus subsp. aureus MRSA252 2861251 YP_040505.1 CDS SAR1092 NC_002952.2 1140120 1141157 D Similar to Bacillus subtilis hypothetical protein YlbC TR:O34586 (EMBL:Z99111) (346 aa) fasta scores: E(): 2.7e-24, 28.691% id in 359 aa, and to Bacillus halodurans hypothetical protein BH2604 TR:Q9K9P1 (EMBL:AP001516) (363 aa) fasta scores: E(): 3.6e-16, 25.620% id in 363 aa; hypothetical protein 1140120..1141157 Staphylococcus aureus subsp. aureus MRSA252 2859637 YP_040506.1 CDS SAR1093 NC_002952.2 1141173 1141607 D Similar to Bacillus subtilis hypothetical protein YlbF TR:O34412 (EMBL:Z99111) (149 aa) fasta scores: E(): 1.2e-17, 40.845% id in 142 aa, and to Bacillus halodurans hypothetical protein BH2596 TR:Q9K9P9 (EMBL:AP001516) (147 aa) fasta scores: E(): 6.4e-16, 40.876% id in 137 aa; hypothetical protein 1141173..1141607 Staphylococcus aureus subsp. aureus MRSA252 2859638 YP_040507.1 CDS SAR1094 NC_002952.2 1141674 1142603 R Similar to Bacillus subtilis glycerophosphoryl diester phosphodiesterase GlpQ SW:GLPQ_BACSU (P37965) (293 aa) fasta scores: E(): 4.4e-13, 27.036% id in 307 aa, and to Bacillus halodurans glycerophosphodiester phosphodiesterase BH1080 TR:Q9KDY1 (EMBL:AP001510) (250 aa) fasta scores: E(): 1.8e-12, 33.984% id in 256 aa; hypothetical protein complement(1141674..1142603) Staphylococcus aureus subsp. aureus MRSA252 2859639 YP_040508.1 CDS SAR1095 NC_002952.2 1142842 1143096 D Similar to Bacillus halodurans hypothetical protein BH2594 TR:Q9K9Q1 (EMBL:AP001516) (92 aa) fasta scores: E(): 8e-05, 27.027% id in 74 aa, and to Bacillus subtilis hypothetical protein YlbG TR:O34658 (EMBL:Z99111) (90 aa) fasta scores: E(): 0.0004, 24.658% id in 73 aa; hypothetical protein 1142842..1143096 Staphylococcus aureus subsp. aureus MRSA252 2859640 YP_040509.1 CDS SAR1096 NC_002952.2 1143099 1143488 R Poor database matches. Similar to Bacillus halodurans hypothetical protein BH2591 TR:Q9K9Q4 (EMBL:AP001516) (129 aa) fasta scores: E(): 9.5e-15, 33.594% id in 128 aa; hypothetical protein complement(1143099..1143488) Staphylococcus aureus subsp. aureus MRSA252 2860002 YP_040510.1 CDS SAR1097 NC_002952.2 1143558 1144100 D Similar to Bacillus halodurans hypothetical protein BH2590 TR:Q9K9Q5 (EMBL:AP001516) (189 aa) fasta scores: E(): 3.1e-26, 47.312% id in 186 aa, and to Bacillus subtilis hypothetical protein YlbH TR:O34331 (EMBL:Z99111) (164 aa) fasta scores: E(): 4.7e-25, 52.229% id in 157 aa; methylase 1143558..1144100 Staphylococcus aureus subsp. aureus MRSA252 2860003 YP_040511.1 CDS coaD NC_002952.2 1144102 1144584 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1144102..1144584 Staphylococcus aureus subsp. aureus MRSA252 2859240 YP_040512.1 CDS SAR1099 NC_002952.2 1144646 1145785 R Similar to Streptococcus pyogenes hypothetical protein SPY0314 TR:Q9A1E8 (EMBL:AE006497) (368 aa) fasta scores: E(): 5.3e-30, 34.341% id in 364 aa, and to Bacillus subtilis hypothetical protein YlbM TR:O34513 (EMBL:Z99111) (415 aa) fasta scores: E(): 7.6e-17, 32.836% id in 402 aa; hypothetical protein complement(1144646..1145785) Staphylococcus aureus subsp. aureus MRSA252 2860004 YP_040513.1 CDS SAR1100 NC_002952.2 1145912 1146469 D Similar to Bacillus subtilis hypothetical protein YlbN TR:O34445 (EMBL:Z99111) (172 aa) fasta scores: E(): 3.8e-14, 33.511% id in 188 aa, and to Bacillus halodurans hypothetical protein BH2584 TR:Q9K9R1 (EMBL:AP001516) (169 aa) fasta scores: E(): 2.3e-13, 34.225% id in 187 aa; hypothetical protein 1145912..1146469 Staphylococcus aureus subsp. aureus MRSA252 2860362 YP_040514.1 CDS rpmF NC_002952.2 1146549 1146722 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1146549..1146722 Staphylococcus aureus subsp. aureus MRSA252 2860161 YP_040515.1 CDS isdB NC_002952.2 1146876 1148834 R Poor database matches. N-terminal region is similar to the C-terminus of Homo sapiens neurofilament triplet H protein NF-H SW:NFH_HUMAN (P12036) (1020 aa) fasta scores: E(): 1.9e-05, 24.107% id in 560 aa. Probable LPXTG-sorted surface protein; iron-regulated heme-iron binding protein complement(1146876..1148834) Staphylococcus aureus subsp. aureus MRSA252 2859674 YP_040516.1 CDS isdA NC_002952.2 1149036 1150100 R N-terminus is similar to N-terminal region of Staphylococcus epidermidis lipase precursor GehD TR:Q9Z4M7 (EMBL:AF090142) (643 aa) fasta scores: E(): 0.0092, 23.827% id in 277 aa. Previously sequenced as Staphylococcus aureus 29-kDa cell surface protein precursor TR:Q9KW67 (EMBL:AB042826) (354 aa) fasta scores: E(): 1.9e-103, 100.000% id in 354 aa. Probable LPXTG-sorted surface protein; iron-regulated heme-iron binding protein complement(1149036..1150100) Staphylococcus aureus subsp. aureus MRSA252 2859673 YP_040517.1 CDS isdC NC_002952.2 1150309 1150992 D Poor database matches. Similar to Bacillus halodurans hypothetical protein BH3299 TR:Q9K7R0 (EMBL:AP001518) (221 aa) fasta scores: E(): 7e-11, 28.037% id in 214 aa. Probable NPQTN-sorted surface protein; surface anchored protein 1150309..1150992 Staphylococcus aureus subsp. aureus MRSA252 2859675 YP_040518.1 CDS isdD NC_002952.2 1150992 1152068 D Poor database matches. Similar to an internal region of Bacillus anthracis virulence plasmid pX01 hypothetical protein pXO1-90 TR:Q9X360 (EMBL:AF065404) (652 aa) fasta scores: E(): 0.28, 22.034% id in 295 aa CDS contains lysine-rich region, residues 155 to 297; hypothetical protein 1150992..1152068 Staphylococcus aureus subsp. aureus MRSA252 2859676 YP_040519.1 CDS isdE NC_002952.2 1152065 1152943 D Similar to Bacillus subtilis iron-uptake system binding protein precursor FeuA SW:FEUA_BACSU (P40409) (317 aa) fasta scores: E(): 6.7e-06, 25.820% id in 244 aa, and to Listeria monocytogenes lipoprotein FufA TR:Q9EXG4 (EMBL:AJ012345) (290 aa) fasta scores: E(): 2e-44, 48.789% id in 289 aa; transport system extracellular binding lipoprotein 1152065..1152943 Staphylococcus aureus subsp. aureus MRSA252 2859677 YP_040520.1 CDS isdF NC_002952.2 1152953 1153921 D Similar to Escherichia coli iron citrate-dependent iron transport, membrane bound protein FecD SW:FECD_ECOLI (P15029) (318 aa) fasta scores: E(): 5e-29, 35.127% id in 316 aa, and to Bacillus halodurans ferrichrome ABC transporter BH3296 TR:Q9K7R3 (EMBL:AP001518) (328 aa) fasta scores: E(): 5.9e-43, 43.614% id in 321 aa; iron/heme permease 1152953..1153921 Staphylococcus aureus subsp. aureus MRSA252 2859678 YP_040521.1 CDS srtB NC_002952.2 1153983 1154717 D Poor database matches. Similar to Bacillus halodurans hypothetical protein BH3294 TR:Q9K7R5 (EMBL:AP001518) (254 aa) fasta scores: E(): 1e-27, 38.462% id in 234 aa. C-terminus is similar to the C-terminal region of Streptococcus pyogenes hypothetical protein SPY0129 TR:Q9A1S1 (EMBL:AE006482) (237 aa) fasta scores: E(): 3.2e-17, 33.333% id in 183 aa; sortase 1153983..1154717 Staphylococcus aureus subsp. aureus MRSA252 2859503 YP_040522.1 CDS SAR1109 NC_002952.2 1154736 1155059 D iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source; heme-degrading monooxygenase IsdG 1154736..1155059 Staphylococcus aureus subsp. aureus MRSA252 2860363 YP_040523.1 CDS SAR1109a NC_002952.2 1155096 1155203 D Doubtful CDS. No database matches; hypothetical protein 1155096..1155203 Staphylococcus aureus subsp. aureus MRSA252 2860364 YP_040524.1 CDS SAR1110 NC_002952.2 1155443 1156183 D Similar to Bacillus subtilis hypothetical protein YsgA TR:P94538 (EMBL:Z75208) (248 aa) fasta scores: E(): 2.1e-39, 45.783% id in 249 aa, and to Bacillus halodurans rRNA methylase BH3112 TR:Q9K894 (EMBL:AP001517) (251 aa) fasta scores: E(): 5.8e-39, 50.000% id in 252 aa; SpoU rRNA methylase 1155443..1156183 Staphylococcus aureus subsp. aureus MRSA252 2860365 YP_040525.1 CDS pheS NC_002952.2 1156564 1157622 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1156564..1157622 Staphylococcus aureus subsp. aureus MRSA252 2859902 YP_040526.1 CDS pheT NC_002952.2 1157622 1160024 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1157622..1160024 Staphylococcus aureus subsp. aureus MRSA252 2859903 YP_040527.1 CDS SAR1113 NC_002952.2 1160194 1161132 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII complement(1160194..1161132) Staphylococcus aureus subsp. aureus MRSA252 2860366 YP_040528.1 CDS SAR1114 NC_002952.2 1161508 1161774 D Similar to Bacillus subtilis hypothetical protein YshA TR:P94542 (EMBL:Z75208) (85 aa) fasta scores: E(): 1e-08, 46.154% id in 78 aa, and to Bacillus halodurans hypothetical protein BH3109 TR:Q9K897 (EMBL:AP001517) (91 aa) fasta scores: E(): 1.5e-06, 45.333% id in 75 aa; hypothetical protein 1161508..1161774 Staphylococcus aureus subsp. aureus MRSA252 2860367 YP_040529.1 CDS SAR1115 NC_002952.2 1161775 1162296 D Similar to Bacillus subtilis hypothetical protein YshB TR:P94543 (EMBL:Z75208) (177 aa) fasta scores: E(): 1.4e-10, 29.885% id in 174 aa, and to Bacillus halodurans hypothetical protein BH3108 TR:Q9K898 (EMBL:AP001517) (179 aa) fasta scores: E(): 5.1e-09, 25.731% id in 171 aa; hypothetical protein 1161775..1162296 Staphylococcus aureus subsp. aureus MRSA252 2860368 YP_040530.1 CDS SAR1116 NC_002952.2 1162369 1164081 D Similar to Bacillus halodurans DNA-dependent DNA polymerase beta chain BH3107 TR:Q9K899 (EMBL:AP001517) (571 aa) fasta scores: E(): 5e-104, 53.439% id in 567 aa, and to Bacillus subtilis hypothetical protein YshC TR:P94544 (EMBL:Z75208) (570 aa) fasta scores: E(): 1.3e-101, 52.807% id in 570 aa; hypothetical protein 1162369..1164081 Staphylococcus aureus subsp. aureus MRSA252 2860369 YP_040531.1 CDS SAR1117 NC_002952.2 1164091 1166439 D MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange; recombination and DNA strand exchange inhibitor protein 1164091..1166439 Staphylococcus aureus subsp. aureus MRSA252 2860370 YP_040532.1 CDS trxA NC_002952.2 1166612 1166926 D Similar to Anabaena sp thioredoxin 1 TrxA SW:THI1_ANASO (P06544) (106 aa) fasta scores: E(): 9.4e-21, 54.286% id in 105 aa. Previously sequenced as Staphylococcus aureus thioredoxin TrxA TR:Q9ZEH4 (EMBL:AJ223480) (104 aa) fasta scores: E(): 9.6e-41, 100.000% id in 104 aa; thioredoxin 1166612..1166926 Staphylococcus aureus subsp. aureus MRSA252 2860405 YP_040533.1 CDS uvrC NC_002952.2 1167250 1169031 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1167250..1169031 Staphylococcus aureus subsp. aureus MRSA252 2860425 YP_040534.1 CDS sdhC NC_002952.2 1169355 1169969 D Similar to Bacillus halodurans succinate dehydrogenase cytochrome b558 SdhC TR:Q9K8B3 (EMBL:AP001517) (209 aa) fasta scores: E(): 6.7e-44, 52.941% id in 204 aa, and to Bacillus subtilis succinate dehydrogenase cytochrome b558 subunit SdhC SW:DHSC_BACSU (P08064) (202 aa) fasta scores: E(): 1.5e-42, 54.040% id in 198 aa; succinate dehydrogenase cytochrome b558 1169355..1169969 Staphylococcus aureus subsp. aureus MRSA252 2859131 YP_040535.1 CDS sdhA NC_002952.2 1170021 1171787 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 1170021..1171787 Staphylococcus aureus subsp. aureus MRSA252 2859129 YP_040536.1 CDS sdhB NC_002952.2 1171787 1172602 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 1171787..1172602 Staphylococcus aureus subsp. aureus MRSA252 2859130 YP_040537.1 CDS murI NC_002952.2 1172841 1173641 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1172841..1173641 Staphylococcus aureus subsp. aureus MRSA252 2861325 YP_040538.1 CDS SAR1124 NC_002952.2 1173653 1174240 D hydrolyzes non-standard nucleotides such as xanthine and inosine; nucleoside-triphosphatase 1173653..1174240 Staphylococcus aureus subsp. aureus MRSA252 2860371 YP_040539.1 CDS SAR1125 NC_002952.2 1174233 1174736 D Similar to Bacillus halodurans hypothetical protein BH3066 TR:Q9K8E0 (EMBL:AP001517) (169 aa) fasta scores: E(): 3.4e-15, 34.375% id in 160 aa, and to Bacillus subtilis hypothetical protein YsnB SW:YSNB_BACSU (P94559) (171 aa) fasta scores: E(): 1.4e-13, 33.962% id in 159 aa; hypothetical protein 1174233..1174736 Staphylococcus aureus subsp. aureus MRSA252 2860372 YP_040540.1 CDS SAR1126 NC_002952.2 1174866 1175033 D No significant database matches. Doubtful CDS, poor translational start sites; hypothetical protein 1174866..1175033 Staphylococcus aureus subsp. aureus MRSA252 2860373 YP_040541.1 CDS SAR1127 NC_002952.2 1175227 1175544 D No significant database matches to the full length CDS. C-terminus is similar to the C-terminal region of Staphylococcus aureus fibrinogen-binding protein precursor Fib TR:Q08691 (EMBL:X72013) (165 aa) fasta scores: E(): 0.00011, 40.909% id in 66 aa; hypothetical protein 1175227..1175544 Staphylococcus aureus subsp. aureus MRSA252 2860374 YP_040542.1 CDS SAR1129 NC_002952.2 1176949 1177455 D Poor database matches. Similar to the N-terminal region of Mycoplasma pulmonis hypothetical protein MYPU_2270 TR:CAC13400 (EMBL:AL445563) (245 aa) fasta scores: E(): 0.028, 23.871% id in 155 aa; hypothetical protein 1176949..1177455 Staphylococcus aureus subsp. aureus MRSA252 2860376 YP_040543.1 CDS fib NC_002952.2 1177712 1178209 D Highly similar to Staphylococcus aureus fibrinogen-binding protein precursor Fib TR:Q08691 (EMBL:X72013) (165 aa) fasta scores: E(): 8.7e-57, 94.545% id in 165 aa. Internal region of the CDS is similar internal regions of Staphylococcus aureus staphylocoagulase precursor SW:STC2_STAAU (P17855) (715 aa) fasta scores: E(): 6.9e-05, 40.541% id in 74 aa; fibrinogen-binding protein precursor 1177712..1178209 Staphylococcus aureus subsp. aureus MRSA252 2860667 YP_040544.1 CDS SAR1131 NC_002952.2 1178361 1178711 D No significant database matches. Similar to SAR2035, 50.000% identity (50.893% ungapped) in 114 aa overlap; hypothetical protein 1178361..1178711 Staphylococcus aureus subsp. aureus MRSA252 2860377 YP_040545.1 CDS SAR1132 NC_002952.2 1178795 1179019 D No significant database matches. Doubtful CDS, poor translational start sites; hypothetical protein 1178795..1179019 Staphylococcus aureus subsp. aureus MRSA252 2860378 YP_040546.1 CDS SAR1133 NC_002952.2 1178960 1179145 R hypothetical protein complement(1178960..1179145) Staphylococcus aureus subsp. aureus MRSA252 2860379 YP_040547.1 CDS SAR1133a NC_002952.2 1179346 1179594 R hypothetical protein complement(1179346..1179594) Staphylococcus aureus subsp. aureus MRSA252 2860380 YP_040548.1 CDS SAR1134 NC_002952.2 1179755 1179988 R hypothetical protein complement(1179755..1179988) Staphylococcus aureus subsp. aureus MRSA252 2860381 YP_040549.1 CDS SAR1136a NC_002952.2 1182069 1182215 D Doubtful CDS. No database matches; hypothetical protein 1182069..1182215 Staphylococcus aureus subsp. aureus MRSA252 2860382 YP_040550.1 CDS SAR1137 NC_002952.2 1182199 1182399 D Poor database matches. Similar to an internal region of bacteriophage APSE-1 hypothetical protein P2 SW:VP02_BPAPS (Q9T1U6) (94 aa) fasta scores: E(): 9.9, 29.508% id in 61 aa. Similar to SAR1303, 54.545% identity (54.545% ungapped) in 66 aa overlap; hypothetical protein 1182199..1182399 Staphylococcus aureus subsp. aureus MRSA252 2860383 YP_040551.1 CDS SAR1138 NC_002952.2 1182701 1184347 D Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 7.6e-199, 99.270% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 4e-99, 51.923% id in 520 aa; transposase 1182701..1184347 Staphylococcus aureus subsp. aureus MRSA252 2860384 YP_040552.1 CDS SAR1139 NC_002952.2 1184717 1185433 R these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein complement(1184717..1185433) Staphylococcus aureus subsp. aureus MRSA252 2860385 YP_040553.1 CDS SAR1140 NC_002952.2 1185542 1186267 R these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein complement(1185542..1186267) Staphylococcus aureus subsp. aureus MRSA252 2860386 YP_040554.1 CDS SAR1141 NC_002952.2 1186377 1187102 R these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation; superantigen-like protein complement(1186377..1187102) Staphylococcus aureus subsp. aureus MRSA252 2860387 YP_040555.1 CDS otc NC_002952.2 1187532 1188533 D catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1187532..1188533 Staphylococcus aureus subsp. aureus MRSA252 2861471 YP_040556.1 CDS SAR1143 NC_002952.2 1188556 1189488 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1188556..1189488 Staphylococcus aureus subsp. aureus MRSA252 2860388 YP_040557.1 CDS SAR1144 NC_002952.2 1189659 1191215 D Similar to Haemophilus influenzae hypothetical protein HI0594 SW:YFCC_HAEIN (P44023) (509 aa) fasta scores: E(): 2.8e-109, 58.527% id in 516 aa, and to Escherichia coli hypothetical protein YfcC SW:YFCC_ECOLI (P39263) (506 aa) fasta scores: E(): 1.3e-34, 28.977% id in 528 aa. C-terminal region is similar to SAR0067, 94.333% identity (94.333% ungapped) in 300 aa overlap; hypothetical protein 1189659..1191215 Staphylococcus aureus subsp. aureus MRSA252 2860389 YP_040558.1 CDS SAR1146 NC_002952.2 1191522 1191749 D Poor database matches. Similar to Escherichia coli O157:H7 hypothetical membrane protein ECS4748 TR:BAB38171 (EMBL:AP002567) (99 aa) fasta scores: E(): 4.1, 30.357% id in 56 aa; hypothetical protein 1191522..1191749 Staphylococcus aureus subsp. aureus MRSA252 2860390 YP_040559.1 CDS SAR1147 NC_002952.2 1192065 1193012 R Similar to Staphylococcus hyicus exfoliative toxin A SHETA TR:Q9FDT4 (EMBL:AB036768) (306 aa) fasta scores: E(): 4.2e-87, 80.132% id in 302 aa, and to Streptococcus pyogenes exfoliative toxin SPY0918 TR:Q9A061 (EMBL:AE006541) (302 aa) fasta scores: E(): 1.7e-37, 41.584% id in 303 aa; hypothetical protein complement(1192065..1193012) Staphylococcus aureus subsp. aureus MRSA252 2860391 YP_040560.1 CDS SAR1148 NC_002952.2 1193259 1193456 D DNA-binding protein 1193259..1193456 Staphylococcus aureus subsp. aureus MRSA252 2861252 YP_040561.1 CDS SAR1150 NC_002952.2 1194355 1194489 D Similar to Staphylococcus haemolyticus antibacterial protein 3 SW:GGI3_STAHA (P11699) (44 aa) fasta scores: E(): 2.1e-08, 70.455% id in 44 aa, and to Staphylococcus lugdunensis hemolysin SLUSH-C TR:P95771 (EMBL:U73444) (43 aa) fasta scores: E(): 0.032, 40.476% id in 42 aa; anti protein 1194355..1194489 Staphylococcus aureus subsp. aureus MRSA252 2861253 YP_040562.1 CDS SAR1151 NC_002952.2 1194622 1195308 D Similar to Bacillus subtilis hypothetical protein YfnB TR:O06480 (EMBL:D86418) (235 aa) fasta scores: E(): 5.2e-29, 41.333% id in 225 aa, and to Streptococcus pyogenes hypothetical protein SPY1066 TR:Q99ZU5 (EMBL:AE006551) (233 aa) fasta scores: E(): 1.2e-20, 31.111% id in 225 aa; haloacid dehalogenase-like hydrolase 1194622..1195308 Staphylococcus aureus subsp. aureus MRSA252 2861254 YP_040563.1 CDS SAR1152 NC_002952.2 1195416 1195856 R Similar to Bacillus subtilis hypothetical protein YlbP TR:O34468 (EMBL:Z99111) (160 aa) fasta scores: E(): 2.7e-22, 46.309% id in 149 aa, and to Bacillus halodurans hypothetical protein BH2580 TR:Q9K9R5 (EMBL:AP001516) (169 aa) fasta scores: E(): 1.4e-20, 43.836% id in 146 aa; hypothetical protein complement(1195416..1195856) Staphylococcus aureus subsp. aureus MRSA252 2861255 YP_040564.1 CDS SAR1153 NC_002952.2 1196051 1197664 D Similar to Bacillus subtilis hypothetical protein YllA SW:YLLA_BACSU (P55342) (539 aa) fasta scores: E(): 1.5e-49, 32.103% id in 542 aa, and to Bacillus halodurans hypothetical protein BH2577 TR:Q9K9R8 (EMBL:AP001516) (538 aa) fasta scores: E(): 3e-44, 31.610% id in 503 aa; hypothetical protein 1196051..1197664 Staphylococcus aureus subsp. aureus MRSA252 2861256 YP_040565.1 CDS SAR1154 NC_002952.2 1197808 1198239 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1197808..1198239 Staphylococcus aureus subsp. aureus MRSA252 2861257 YP_040566.1 CDS mraW NC_002952.2 1198255 1199190 D Similar to Bacillus subtilis hypothetical protein YllC SW:YLXA_BACSU (Q07876) (311 aa) fasta scores: E(): 9.9e-77, 64.610% id in 308 aa, and to Enterococcus hirae hypothetical protein MraW TR:O07665 (EMBL:Y13922) (319 aa) fasta scores: E(): 8.5e-74, 64.423% id in 312 aa; S-adenosyl-methyltransferase MraW 1198255..1199190 Staphylococcus aureus subsp. aureus MRSA252 2861258 YP_040567.1 CDS SAR1156 NC_002952.2 1199204 1199605 D Similar to Bacillus subtilis cell division protein FtsL homologue SW:FTSL_BACSU (Q07867) (117 aa) fasta scores: E(): 0.0016, 26.786% id in 112 aa, and to Staphylococcus aureus. Previously sequenced as cell division protein YllD TR:O07321 (EMBL:U94706) (133 aa) fasta scores: E(): 2.6e-44, 100.000% id in 133 aa; cell division protein 1199204..1199605 Staphylococcus aureus subsp. aureus MRSA252 2861259 YP_040568.1 CDS pbpA NC_002952.2 1199586 1201820 D Similar to Bacillus subtilis penicillin-binding protein 2B PbpB SW:PBPB_BACSU (Q07868) (716 aa) fasta scores: E(): 2.2e-98, 40.503% id in 716 aa. Previously sequenced as Staphylococcus aureus penicillin-binding protein 1 PbpA TR:Q53725 (EMBL:U94706) (744 aa) fasta scores: E(): 0, 99.866% id in 744 aa; penicillin-binding protein 1 1199586..1201820 Staphylococcus aureus subsp. aureus MRSA252 2861478 YP_040569.1 CDS mraY NC_002952.2 1202112 1203077 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1202112..1203077 Staphylococcus aureus subsp. aureus MRSA252 2861309 YP_040570.1 CDS murD NC_002952.2 1203079 1204428 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1203079..1204428 Staphylococcus aureus subsp. aureus MRSA252 2861322 YP_040571.1 CDS SAR1160 NC_002952.2 1204441 1205763 D Similar to Bacillus subtilis division initiation protein Dds SW:DIVB_BACSU (P16655) (263 aa) fasta scores: E(): 3.3e-15, 28.897% id in 263 aa. Previously sequenced as Staphylococcus aureus cell division protein Div1B TR:O07324 (EMBL:U94706) (439 aa) fasta scores: E(): 8.7e-133, 96.811% id in 439 aa; cell division protein 1204441..1205763 Staphylococcus aureus subsp. aureus MRSA252 2861260 YP_040572.1 CDS ftsA NC_002952.2 1205869 1207275 D Similar to Bacillus subtilis cell division protein FtsA SW:FTSA_BACSU (P28264) (440 aa) fasta scores: E(): 1.7e-37, 30.687% id in 466 aa. Previously sequenced as Staphylococcus aureus cell division protein FtsA SW:FTSA_STAAU (O07325) (471 aa) fasta scores: E(): 9.5e-141, 89.451% id in 474 aa; cell division protein 1205869..1207275 Staphylococcus aureus subsp. aureus MRSA252 2860683 YP_040573.1 CDS ftsZ NC_002952.2 1207308 1208480 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1207308..1208480 Staphylococcus aureus subsp. aureus MRSA252 2860685 YP_040574.1 CDS SAR1163 NC_002952.2 1208738 1209529 D Similar to Bacillus subtilis hypothetical protein YlmD SW:YLMD_BACSU (O31726) (278 aa) fasta scores: E(): 2.1e-27, 31.984% id in 247 aa, and to Bacillus halodurans hypothetical protein BH2551 TR:Q9K9U4 (EMBL:AP001515) (273 aa) fasta scores: E(): 3.6e-24, 34.274% id in 248 aa; hypothetical protein 1208738..1209529 Staphylococcus aureus subsp. aureus MRSA252 2861261 YP_040575.1 CDS SAR1164 NC_002952.2 1209547 1210221 D Similar to Bacillus halodurans hypothetical protein BH2550 TR:Q9K9U5 (EMBL:AP001515) (228 aa) fasta scores: E(): 5e-42, 53.982% id in 226 aa, and to Bacillus subtilis hypothetical protein YlmE SW:YLME_BACSU (O31727) (230 aa) fasta scores: E(): 5.1e-42, 55.357% id in 224 aa; hypothetical protein 1209547..1210221 Staphylococcus aureus subsp. aureus MRSA252 2861262 YP_040576.1 CDS SAR1165 NC_002952.2 1210218 1210781 D Similar to Streptococcus pyogenes hypothetical protein SPY1518 TR:Q99YV9 (EMBL:AE006585) (218 aa) fasta scores: E(): 1.1e-05, 25.234% id in 214 aa. C-terminus is similar to the C-terminal region of Bacillus subtilis hypothetical protein YlmF TR:O31728 (EMBL:Z99112) (149 aa) fasta scores: E(): 1.3e-18, 56.198% id in 121 aa; hypothetical protein 1210218..1210781 Staphylococcus aureus subsp. aureus MRSA252 2861263 YP_040577.1 CDS SAR1166 NC_002952.2 1210793 1211083 D Similar to Bacillus subtilis hypothetical protein YlmG TR:O31729 (EMBL:Z99112) (90 aa) fasta scores: E(): 2.4e-14, 51.724% id in 87 aa, and to Bacillus halodurans hypothetical protein BH2548 TR:Q9K9U7 (EMBL:AP001515) (84 aa) fasta scores: E(): 8.2e-12, 46.988% id in 83 aa; hypothetical protein 1210793..1211083 Staphylococcus aureus subsp. aureus MRSA252 2861264 YP_040578.1 CDS SAR1167 NC_002952.2 1211166 1211972 D Similar to Bacillus halodurans hypothetical protein BH2547 TR:Q9K9U8 (EMBL:AP001515) (258 aa) fasta scores: E(): 7.5e-40, 48.193% id in 249 aa, and to Bacillus subtilis hypothetical protein YlmH TR:P71020 (EMBL:U60901) (257 aa) fasta scores: E(): 4.6e-33, 40.079% id in 252 aa; hypothetical protein 1211166..1211972 Staphylococcus aureus subsp. aureus MRSA252 2861265 YP_040579.1 CDS SAR1168 NC_002952.2 1211996 1212592 D Similar to Bacillus subtilis minicell-associated protein DivIVA TR:P71021 (EMBL:U60901) (164 aa) fasta scores: E(): 1.9e-17, 41.139% id in 158 aa, and to Bacillus halodurans cell-division initiation protein BH2546 TR:Q9K9U9 (EMBL:AP001515) (165 aa) fasta scores: E(): 2.8e-14, 35.570% id in 149 aa. Contains coiled-coiled domain, residues 36 to 53; hypothetical protein 1211996..1212592 Staphylococcus aureus subsp. aureus MRSA252 2861266 YP_040580.1 CDS ileS NC_002952.2 1212813 1215566 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1212813..1215566 Staphylococcus aureus subsp. aureus MRSA252 2859661 YP_040581.1 CDS SAR1170 NC_002952.2 1215677 1216624 R Identical to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 2.7e-127, 100.000% id in 315 aa, and similar to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 2.9e-71, 58.413% id in 315 aa; transposase complement(1215677..1216624) Staphylococcus aureus subsp. aureus MRSA252 2861267 YP_040582.1 CDS SAR1171 NC_002952.2 1216898 1217695 D N-terminal region is similar to Rhodococcus globerulus biphenyl-2,3-diol 1,2-dioxygenase III bphC3 SW:BHC3_RHOGO (P47233) (189 aa) fasta scores: E(): 0.011, 23.837% id in 172 aa. Full length CDS is similar to Rhizobium loti hypothetical protein MLR0078 TR:BAB47738 (EMBL:AP002994) (270 aa) fasta scores: E(): 2.6e-15, 27.273% id in 253 aa; glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein 1216898..1217695 Staphylococcus aureus subsp. aureus MRSA252 2861268 YP_040583.1 CDS lspA NC_002952.2 1217944 1218435 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1217944..1218435 Staphylococcus aureus subsp. aureus MRSA252 2859810 YP_040584.1 CDS SAR1173 NC_002952.2 1218435 1219352 D Similar to Bacillus subtilis hypothetical protein YlyB SW:YLYB_BACSU (Q45480) (303 aa) fasta scores: E(): 5.9e-76, 65.217% id in 299 aa, and to Bacillus halodurans hypothetical protein BH2542 TR:Q9K9V3 (EMBL:AP001515) (305 aa) fasta scores: E(): 1.6e-69, 61.538% id in 299 aa; RNA pseudouridylate synthase 1218435..1219352 Staphylococcus aureus subsp. aureus MRSA252 2861269 YP_040585.1 CDS pyrR NC_002952.2 1219754 1220281 D regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 1219754..1220281 Staphylococcus aureus subsp. aureus MRSA252 2859291 YP_040586.1 CDS pyrP NC_002952.2 1220499 1221806 D Similar to Bacillus subtilis uracil permease PyrP SW:PYRP_BACSU (P39766) (434 aa) fasta scores: E(): 3.9e-74, 55.504% id in 427 aa, and to Bacillus caldolyticus uracil permease PyrP SW:PYRP_BACCL (P41006) (432 aa) fasta scores: E(): 4.8e-82, 58.993% id in 417 aa; uracil permease 1220499..1221806 Staphylococcus aureus subsp. aureus MRSA252 2859290 YP_040587.1 CDS pyrB NC_002952.2 1221834 1222715 D catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 1221834..1222715 Staphylococcus aureus subsp. aureus MRSA252 2859284 YP_040588.1 CDS pyrC NC_002952.2 1222733 1224007 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1222733..1224007 Staphylococcus aureus subsp. aureus MRSA252 2859285 YP_040589.1 CDS pyrAA NC_002952.2 1224009 1225109 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1224009..1225109 Staphylococcus aureus subsp. aureus MRSA252 2859282 YP_040590.1 CDS carB NC_002952.2 1225102 1228275 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1225102..1228275 Staphylococcus aureus subsp. aureus MRSA252 2859283 YP_040591.1 CDS pyrF NC_002952.2 1228382 1229077 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1228382..1229077 Staphylococcus aureus subsp. aureus MRSA252 2859287 YP_040592.1 CDS pyrE NC_002952.2 1229077 1229688 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 1229077..1229688 Staphylococcus aureus subsp. aureus MRSA252 2859286 YP_040593.1 CDS SAR1182 NC_002952.2 1229718 1229930 D hypothetical protein 1229718..1229930 Staphylococcus aureus subsp. aureus MRSA252 2861270 YP_040594.1 CDS SAR1183 NC_002952.2 1230367 1230768 D Similar to Pseudomonas aeruginosa hypothetical protein PA1358 TR:Q9I3Y6 (EMBL:AE004565) (132 aa) fasta scores: E(): 1.9e-15, 40.625% id in 128 aa, and to the N-terminal region of Rhizobium loti hypothetical protein MLL5357 TR:BAB51820 (EMBL:AP003006) (156 aa) fasta scores: E(): 9e-06, 35.115% id in 131 aa; hypothetical protein 1230367..1230768 Staphylococcus aureus subsp. aureus MRSA252 2861271 YP_040595.1 CDS SAR1184 NC_002952.2 1231031 1232728 R Similar to Bacillus subtilis fibronectin-binding protein YloA TR:O34693 (EMBL:AJ000974) (572 aa) fasta scores: E(): 2.2e-91, 46.410% id in 571 aa, and to Bacillus halodurans possible fibronectin/fibrinogen-binding protein BH2516 TR:Q9K9X8 (EMBL:AP001515) (570 aa) fasta scores: E(): 8.1e-88, 44.386% id in 570 aa. Contains coiled-coiled domain, residues 296 to 312; hypothetical protein complement(1231031..1232728) Staphylococcus aureus subsp. aureus MRSA252 2861272 YP_040596.1 CDS gmk NC_002952.2 1233003 1233626 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1233003..1233626 Staphylococcus aureus subsp. aureus MRSA252 2861273 YP_040597.1 CDS rpoZ NC_002952.2 1233626 1233844 D Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1233626..1233844 Staphylococcus aureus subsp. aureus MRSA252 2861274 YP_040598.1 CDS SAR1187 NC_002952.2 1234060 1235259 D Similar to Bacillus halodurans flavoprotein BH2510 TR:Q9K9Y4 (EMBL:AP001515) (404 aa) fasta scores: E(): 6.3e-76, 53.083% id in 373 aa, and to Bacillus subtilis hypothetical protein YloI TR:O35033 (EMBL:Z99112) (406 aa) fasta scores: E(): 1.4e-75, 54.315% id in 394 aa; flavoprotein 1234060..1235259 Staphylococcus aureus subsp. aureus MRSA252 2861275 YP_040599.1 CDS priA NC_002952.2 1235259 1237667 D Similar to Escherichia coli primosomal protein n' PriA SW:PRIA_ECOLI (P17888) (732 aa) fasta scores: E(): 8.6e-76, 35.115% id in 786 aa, and to Bacillus subtilis primosomal protein n' PriA SW:PRIA_BACSU (P94461) (805 aa) fasta scores: E(): 1.3e-151, 50.619% id in 808 aa; primosomal protein n' 1235259..1237667 Staphylococcus aureus subsp. aureus MRSA252 2860151 YP_040600.1 CDS SAR1189 NC_002952.2 1238170 1239123 D Poor database matches. C-terminus is similar to internal region of Bacillus subtilis hypothetical protein YkvD protein ykvD TR:O31671 (EMBL:Z99111) (506 aa) fasta scores: E(): 6.4, 23.194% id in 263 aa; lipoprotein 1238170..1239123 Staphylococcus aureus subsp. aureus MRSA252 2861276 YP_040601.1 CDS SAR1190 NC_002952.2 1239286 1239564 R Poor database matches. Similar to Borrelia burgdorferi conserved hypothetical protein BBQ01 TR:Q9S015 (EMBL:AE001584) (89 aa) fasta scores: E(): 0.0016, 31.818% id in 88 aa. C-terminus is similar to the N-terminal region of Synechocystis sp hypothetical protein SLL0498 TR:Q55491 (EMBL:D64006) (150 aa) fasta scores: E(): 2.3e-06, 52.000% id in 50 aa. C-terminus is similar to the C-terminal region of SAR1013, 58.209% identity (59.091% ungapped) in 67 aa overlap; hypothetical protein complement(1239286..1239564) Staphylococcus aureus subsp. aureus MRSA252 2861277 YP_040602.1 CDS def NC_002952.2 1239788 1240276 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1239788..1240276 Staphylococcus aureus subsp. aureus MRSA252 2859267 YP_040603.1 CDS SAR1192 NC_002952.2 1240269 1241204 D Similar to Escherichia coli methionyl-tRNA formyltransferase Fmt SW:FMT_ECOLI (P23882) (314 aa) fasta scores: E(): 9.7e-41, 39.228% id in 311 aa, and to Bacillus halodurans methionyl-tRNA formyltransferase BH2508 TR:Q9K9Y6 (EMBL:AP001515) (317 aa) fasta scores: E(): 7.4e-66, 59.355% id in 310 aa; methionyl-tRNA formyltransferase 1240269..1241204 Staphylococcus aureus subsp. aureus MRSA252 2861278 YP_040604.1 CDS SAR1193 NC_002952.2 1241201 1242508 D Similar to Escherichia coli protein hypothetical protein Sun SW:SUN_ECOLI (P36929) (429 aa) fasta scores: E(): 7.7e-31, 29.306% id in 447 aa, and to Bacillus subtilis hypothetical protein Sun SW:SUN_BACSU (P94464) (447 aa) fasta scores: E(): 1.4e-58, 40.724% id in 442 aa; hypothetical protein 1241201..1242508 Staphylococcus aureus subsp. aureus MRSA252 2861279 YP_040605.1 CDS SAR1194 NC_002952.2 1242511 1243605 D 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 1242511..1243605 Staphylococcus aureus subsp. aureus MRSA252 2861280 YP_040606.1 CDS SAR1195 NC_002952.2 1243612 1244355 D Similar to Bacillus halodurans hypothetical protein BH2505 TR:Q9K9Y9 (EMBL:AP001515) (249 aa) fasta scores: E(): 3.2e-33, 42.917% id in 240 aa, and to Bacillus subtilis hypothetical protein YloO TR:O34779 (EMBL:Z99112) (254 aa) fasta scores: E(): 1.6e-30, 42.324% id in 241 aa; protein phosphatase 1243612..1244355 Staphylococcus aureus subsp. aureus MRSA252 2861281 YP_040607.1 CDS pknB NC_002952.2 1244352 1246346 D N-terminus is similar to N-terminal region of Myxococcus xanthus serine/threonine-protein kinase Pkn1 SW:PKN1_MYXXA (P33973) (693 aa) fasta scores: E(): 8.5e-23, 34.317% id in 271 aa. Previously sequenced as Staphylococcus aureus protein kinase PknB TR:Q9KX10 (EMBL:Y13639) (388 aa) fasta scores: E(): 7e-131, 100.000% id in 388 aa; serine/threonine-protein kinase 1244352..1246346 Staphylococcus aureus subsp. aureus MRSA252 2859907 YP_040608.1 CDS SAR1197 NC_002952.2 1246574 1247449 D Similar to Bacillus subtilis hypothetical protein YloQ TR:O34530 (EMBL:Z99112) (298 aa) fasta scores: E(): 9.8e-44, 44.667% id in 300 aa, and to Lactococcus lactis hypothetical protein YuaD TR:Q9CEB7 (EMBL:AE006423) (307 aa) fasta scores: E(): 4e-43, 45.302% id in 298 aa; hypothetical protein 1246574..1247449 Staphylococcus aureus subsp. aureus MRSA252 2861282 YP_040609.1 CDS SAR1198 NC_002952.2 1247450 1248094 D Similar to Spinacia oleracea ribulose-phosphate 3-epimerase precursor Rpe SW:RPE_SPIOL (Q43157) (285 aa) fasta scores: E(): 6.6e-36, 51.905% id in 210 aa, and to Bacillus halodurans ribulose-phosphate 3-epimerase BH2502 TR:Q9K9Z2 (EMBL:AP001515) (216 aa) fasta scores: E(): 3.2e-41, 54.673% id in 214 aa. The S. oleracea protein is extented by 60 residues at the N-terminus; ribulose-phosphate 3-epimerase 1247450..1248094 Staphylococcus aureus subsp. aureus MRSA252 2861283 YP_040610.1 CDS SAR1199 NC_002952.2 1248101 1248742 D Similar to Bacillus subtilis hypothetical protein YloS TR:O34664 (EMBL:Z99112) (214 aa) fasta scores: E(): 4.4e-27, 43.192% id in 213 aa. Internal region of the CDS is similar to an internal region of Mus musculus thiamin pyrophosphokinase TPK1 TR:Q9R0M5 (EMBL:AB027568) (243 aa) fasta scores: E(): 4.9e-05, 26.087% id in 161 aa; hypothetical protein 1248101..1248742 Staphylococcus aureus subsp. aureus MRSA252 2861284 YP_040611.1 CDS rpmB NC_002952.2 1249123 1249311 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(1249123..1249311) Staphylococcus aureus subsp. aureus MRSA252 2860922 YP_040612.1 CDS SAR1201 NC_002952.2 1249754 1250128 D Similar to Bacillus subtilis hypothetical protein YloU TR:O34318 (EMBL:Z99112) (120 aa) fasta scores: E(): 8.7e-26, 60.504% id in 119 aa, and to Bacillus halodurans hypothetical protein BH2499 TR:Q9K9Z5 (EMBL:AP001515) (120 aa) fasta scores: E(): 1.7e-24, 55.462% id in 119 aa; hypothetical protein 1249754..1250128 Staphylococcus aureus subsp. aureus MRSA252 2861285 YP_040613.1 CDS SAR1202 NC_002952.2 1250143 1251789 D Similar to Bacillus subtilis hypothetical protein YloV TR:O34751 (EMBL:Z99112) (553 aa) fasta scores: E(): 1.6e-111, 55.354% id in 551 aa, and to Bacillus halodurans hypothetical protein BH2498 TR:Q9K9Z6 (EMBL:AP001515) (557 aa) fasta scores: E(): 7.4e-105, 52.338% id in 556 aa; hypothetical protein 1250143..1251789 Staphylococcus aureus subsp. aureus MRSA252 2861286 YP_040614.1 CDS recG NC_002952.2 1251979 1254039 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1251979..1254039 Staphylococcus aureus subsp. aureus MRSA252 2859302 YP_040615.1 CDS SAR1204 NC_002952.2 1254257 1254814 D negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria; fatty acid biosynthesis transcriptional regulator 1254257..1254814 Staphylococcus aureus subsp. aureus MRSA252 2861287 YP_040616.1 CDS SAR1205 NC_002952.2 1254819 1255805 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1254819..1255805 Staphylococcus aureus subsp. aureus MRSA252 2861288 YP_040617.1 CDS fabD NC_002952.2 1255798 1256724 D Similar to Escherichia coli malonyl CoA-acyl carrier protein transacylase FabD SW:FABD_ECOLI (P25715) (308 aa) fasta scores: E(): 9e-38, 39.931% id in 288 aa, and to Bacillus subtilis malonyl CoA-acyl carrier protein transacylase FabD SW:FABD_BACSU (P71019) (317 aa) fasta scores: E(): 6.3e-47, 46.711% id in 304 aa; malonyl CoA-ACP transacylase 1255798..1256724 Staphylococcus aureus subsp. aureus MRSA252 2859617 YP_040618.1 CDS fabG NC_002952.2 1256711 1257451 D Similar to Bacillus subtilis 3-oxoacyl-[acyl-carrier protein] reductase FabG SW:FABG_BACSU (P51831) (246 aa) fasta scores: E(): 1.2e-54, 64.228% id in 246 aa, and to Bacillus halodurans 3-oxoacyl-[acyl-carrier protein] reductase BH2491 TR:Q9KA03 (EMBL:AP001515) (246 aa) fasta scores: E(): 1.8e-55, 67.886% id in 246 aa; 3-oxoacyl-ACP reductase 1256711..1257451 Staphylococcus aureus subsp. aureus MRSA252 2859619 YP_040619.1 CDS acpP NC_002952.2 1257757 1257990 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1257757..1257990 Staphylococcus aureus subsp. aureus MRSA252 2859057 YP_040620.1 CDS rnc NC_002952.2 1258106 1258837 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1258106..1258837 Staphylococcus aureus subsp. aureus MRSA252 2860435 YP_040621.1 CDS SAR1210 NC_002952.2 1258984 1262550 D Similar to Bacillus subtilis chromosome partition protein Smc SW:SMC_BACSU (P51834) (1186 aa) fasta scores: E(): 5.6e-123, 42.366% id in 1192 aa, and to Gallus gallus chromosome scaffold protein SciI SW:SCII_CHICK (Q90988) (1189 aa) fasta scores: E(): 7.6e-41, 23.977% id in 1197 aa. CDS contains several coiled-coiled domains, between residues 246 to 470 and 687 to 903; chromosome partition protein 1258984..1262550 Staphylococcus aureus subsp. aureus MRSA252 2860436 YP_040622.1 CDS SAR1211 NC_002952.2 1262550 1263800 D Internal region is similar to Bacillus subtilis cell division protein FtsY homologue Srb SW:FTSY_BACSU (P51835) (329 aa) fasta scores: E(): 8e-71, 69.470% id in 321 aa. Similar to the C-terminal region of Escherichia coli cell division protein FtsY SW:FTSY_ECOLI (P10121) (497 aa) fasta scores: E(): 6.7e-45, 44.063% id in 379 aa; cell division protein 1262550..1263800 Staphylococcus aureus subsp. aureus MRSA252 2860437 YP_040623.1 CDS SAR1212 NC_002952.2 1263787 1264119 D Similar to Bacillus halodurans hypothetical protein BH2485 TR:Q9KA09 (EMBL:AP001515) (109 aa) fasta scores: E(): 2e-16, 57.143% id in 105 aa, and to Bacillus subtilis hypothetical protein YlxM SW:YLXM_BACSU (P37104) (110 aa) fasta scores: E(): 5.2e-16, 54.630% id in 108 aa; DNA-binding protein 1263787..1264119 Staphylococcus aureus subsp. aureus MRSA252 2860438 YP_040624.1 CDS ffh NC_002952.2 1264145 1265512 D Similar to Bacillus subtilis signal recognition particle protein Ffh SW:SR54_BACSU (P37105) (446 aa) fasta scores: E(): 8.5e-105, 70.110% id in 455 aa, and to Escherichia coli, and signal recognition particle protein Ffh TR:AAG57721 (EMBL:X01818) (453 aa) fasta scores: E(): 9.5e-74, 51.214% id in 453 aa; signal recognition particle protein 1264145..1265512 Staphylococcus aureus subsp. aureus MRSA252 2860662 YP_040625.1 CDS rpsP NC_002952.2 1265947 1266222 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 1265947..1266222 Staphylococcus aureus subsp. aureus MRSA252 2861452 YP_040626.1 CDS rimM NC_002952.2 1266410 1266913 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 1266410..1266913 Staphylococcus aureus subsp. aureus MRSA252 2859271 YP_040627.1 CDS trmD NC_002952.2 1266913 1267650 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 1266913..1267650 Staphylococcus aureus subsp. aureus MRSA252 2860396 YP_040628.1 CDS rplS NC_002952.2 1267753 1268103 D this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1267753..1268103 Staphylococcus aureus subsp. aureus MRSA252 2860914 YP_040629.1 CDS SAR1218 NC_002952.2 1268347 1270953 R Similar to Bacillus subtilis hypothetical protein YfhO TR:O31582 (EMBL:Z99108) (819 aa) fasta scores: E(): 1.7e-57, 28.193% id in 830 aa, and to Streptococcus pyogenes hypothetical protein SPY2211 TR:Q99XH1 (EMBL:AE006638) (858 aa) fasta scores: E(): 7.2e-05, 20.465% id in 904 aa. CDS extended at the N-terminus in comparison to the B. subtilis protein; hypothetical protein complement(1268347..1270953) Staphylococcus aureus subsp. aureus MRSA252 2860439 YP_040630.1 CDS rbgA NC_002952.2 1271354 1272238 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1271354..1272238 Staphylococcus aureus subsp. aureus MRSA252 2860440 YP_040631.1 CDS rnhB NC_002952.2 1272222 1272989 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1272222..1272989 Staphylococcus aureus subsp. aureus MRSA252 2859276 YP_040632.1 CDS sucC NC_002952.2 1273098 1274264 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1273098..1274264 Staphylococcus aureus subsp. aureus MRSA252 2860441 YP_040633.1 CDS SAR1222 NC_002952.2 1274286 1275194 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 1274286..1275194 Staphylococcus aureus subsp. aureus MRSA252 2860442 YP_040634.1 CDS lytN NC_002952.2 1275421 1276539 D Similar to Staphylococcus aureus cell wall hydrolase LytN TR:Q9ZNI1 (EMBL:AB015195) (383 aa) fasta scores: E(): 7.4e-138, 96.345% id in 383 aa. C-terminus is similar to the N-terminal region of bacteriophage phi ETA Orf65 TR:Q9FZY0 (EMBL:AP001553) (470 aa) fasta scores: E(): 1.4e-19, 45.714% id in 140 aa; cell wall hydrolase 1275421..1276539 Staphylococcus aureus subsp. aureus MRSA252 2859817 YP_040635.1 CDS fmhC NC_002952.2 1276567 1277811 D Similar to Staphylococcus simulans lysostaphin immunity factor Lif TR:O05989 (EMBL:U66883) (413 aa) fasta scores: E(): 1.3e-89, 56.174% id in 413 aa, and to Staphylococcus aureus hypothetical protein FmhC TR:Q9S685 (EMBL:AF106851) (414 aa) fasta scores: E(): 1.3e-153, 99.275% id in 414 aa. Similar to SAR2501, 60.934% identity (60.934% ungapped) in 407 aa overlap; FemAB family protein 1276567..1277811 Staphylococcus aureus subsp. aureus MRSA252 2860670 YP_040636.1 CDS SAR1225 NC_002952.2 1277983 1278855 D Similar to Bacillus halodurans DNA processing protein BH2468 TR:Q9KA22 (EMBL:AP001515) (302 aa) fasta scores: E(): 4.1e-29, 41.880% id in 234 aa, and to Bacillus subtilis DNA processing Smf protein homologue SW:SMF_BACSU (P39813) (297 aa) fasta scores: E(): 8.5e-29, 40.455% id in 220 aa; SMF family protein 1277983..1278855 Staphylococcus aureus subsp. aureus MRSA252 2860443 YP_040637.1 CDS topA NC_002952.2 1279035 1281104 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1279035..1281104 Staphylococcus aureus subsp. aureus MRSA252 2860393 YP_040638.1 CDS SAR1227 NC_002952.2 1281260 1282567 D TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 1281260..1282567 Staphylococcus aureus subsp. aureus MRSA252 2860444 YP_040639.1 CDS SAR1228 NC_002952.2 1282985 1283881 D Similar to Escherichia coli integrase/recombinase XerD SW:XERD_ECOLI (P21891) (298 aa) fasta scores: E(): 8.1e-32, 39.175% id in 291 aa, and to Bacillus subtilis probable integrase/recombinase CodV SW:CODV_BACSU (P39776) (304 aa) fasta scores: E(): 4.4e-47, 45.485% id in 299 aa; integrase/recombinase 1282985..1283881 Staphylococcus aureus subsp. aureus MRSA252 2860445 YP_040640.1 CDS hslV NC_002952.2 1283878 1284423 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 1283878..1284423 Staphylococcus aureus subsp. aureus MRSA252 2859648 YP_040641.1 CDS hslU NC_002952.2 1284489 1285892 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 1284489..1285892 Staphylococcus aureus subsp. aureus MRSA252 2860446 YP_040642.1 CDS codY NC_002952.2 1285917 1286690 D CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 1285917..1286690 Staphylococcus aureus subsp. aureus MRSA252 2859242 YP_040643.1 CDS rpsB NC_002952.2 1287032 1287799 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1287032..1287799 Staphylococcus aureus subsp. aureus MRSA252 2860173 YP_040644.1 CDS tsf NC_002952.2 1287981 1288862 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1287981..1288862 Staphylococcus aureus subsp. aureus MRSA252 2860407 YP_040645.1 CDS pyrH NC_002952.2 1288999 1289721 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1288999..1289721 Staphylococcus aureus subsp. aureus MRSA252 2859289 YP_040646.1 CDS frr NC_002952.2 1289740 1290294 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 1289740..1290294 Staphylococcus aureus subsp. aureus MRSA252 2860681 YP_040647.1 CDS uppS NC_002952.2 1290667 1291437 D catalyzes the formation of UDP pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 1290667..1291437 Staphylococcus aureus subsp. aureus MRSA252 2860415 YP_040648.1 CDS SAR1237 NC_002952.2 1291444 1292226 D Similar to Escherichia coli phosphatidate cytidylyltransferase CdsA SW:CDSA_ECOLI (P06466) (249 aa) fasta scores: E(): 2.7e-18, 35.455% id in 220 aa, and to Bacillus subtilis phosphatidate cytidylyltransferase CdsA SW:CDSA_BACSU (O31752) (269 aa) fasta scores: E(): 3.7e-40, 46.565% id in 262 aa; phosphatidate cytidylyltransferase 1291444..1292226 Staphylococcus aureus subsp. aureus MRSA252 2860447 YP_040649.1 CDS SAR1238 NC_002952.2 1292438 1293724 D Similar to Bacillus subtilis hypothetical protein YluC TR:O31754 (EMBL:Z99112) (422 aa) fasta scores: E(): 1.4e-64, 42.494% id in 433 aa, and to Bacillus halodurans hypothetical protein BH2420 TR:Q9KA70 (EMBL:AP001515) (420 aa) fasta scores: E(): 1.7e-58, 40.326% id in 429 aa; hypothetical protein 1292438..1293724 Staphylococcus aureus subsp. aureus MRSA252 2860448 YP_040650.1 CDS proS NC_002952.2 1293744 1295447 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1293744..1295447 Staphylococcus aureus subsp. aureus MRSA252 2860153 YP_040651.1 CDS polC NC_002952.2 1295705 1300021 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 1295705..1300021 Staphylococcus aureus subsp. aureus MRSA252 2861012 YP_040652.1 CDS SAR1241 NC_002952.2 1300311 1300778 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 1300311..1300778 Staphylococcus aureus subsp. aureus MRSA252 2860449 YP_040653.1 CDS nusA NC_002952.2 1300799 1301974 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1300799..1301974 Staphylococcus aureus subsp. aureus MRSA252 2859171 YP_040654.1 CDS SAR1243 NC_002952.2 1301995 1302279 D Similar to Bacillus halodurans hypothetical protein BH2415 TR:Q9KA75 (EMBL:AP001515) (91 aa) fasta scores: E(): 7.4e-11, 46.988% id in 83 aa, and to Bacillus subtilis hypothetical protein YlxR SW:YLXR_BACSU (P32728) (91 aa) fasta scores: E(): 7.4e-11, 45.161% id in 93 aa; hypothetical protein 1301995..1302279 Staphylococcus aureus subsp. aureus MRSA252 2860450 YP_040655.1 CDS SAR1244 NC_002952.2 1302276 1302593 D Similar to Gallus gallus 60S ribosomal protein L30 SW:RL30_CHICK (P47833) (114 aa) fasta scores: E(): 0.0062, 33.333% id in 102 aa, and to Bacillus subtilis probable ribosomal protein YlxQ SW:YLXQ_BACSU (P32729) (100 aa) fasta scores: E(): 5.6e-15, 50.000% id in 100 aa; ribosomal protein 1302276..1302593 Staphylococcus aureus subsp. aureus MRSA252 2860451 YP_040656.1 CDS infB NC_002952.2 1302598 1304715 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1302598..1304715 Staphylococcus aureus subsp. aureus MRSA252 2859668 YP_040657.1 CDS rbfA NC_002952.2 1305102 1305452 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 1305102..1305452 Staphylococcus aureus subsp. aureus MRSA252 2859299 YP_040658.1 CDS SAR1247 NC_002952.2 1305622 1306539 D catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1305622..1306539 Staphylococcus aureus subsp. aureus MRSA252 2860452 YP_040659.1 CDS SAR1248 NC_002952.2 1306554 1307525 D Similar to Bacillus subtilis riboflavin biosynthesis protein RibC [includes: riboflavin kinase, FMN adenylyltransferase] RibC SW:RIBC_BACSU (P54575) (316 aa) fasta scores: E(): 8.9e-46, 44.660% id in 309 aa, and to Bacillus halodurans riboflavin biosynthesis protein BH2409 TR:Q9KA81 (EMBL:AP001515) (313 aa) fasta scores: E(): 3.4e-43, 42.903% id in 310 aa; riboflavin biosynthesis protein 1306554..1307525 Staphylococcus aureus subsp. aureus MRSA252 2860005 YP_040660.1 CDS rpsO NC_002952.2 1307640 1307909 D primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1307640..1307909 Staphylococcus aureus subsp. aureus MRSA252 2861451 YP_040661.1 CDS pnpA NC_002952.2 1308278 1310374 D Similar to Bacillus subtilis polyribonucleotide nucleotidyltransferase PnpA SW:PNP_BACSU (P50849) (704 aa) fasta scores: E(): 4.3e-165, 68.012% id in 694 aa, and to Bacillus halodurans polynucleotide phosphorylase BH2407 TR:Q9KA83 (EMBL:AP001515) (704 aa) fasta scores: E(): 4.1e-163, 66.523% id in 696 aa; polynucleotide phosphorylase/polyadenylase 1308278..1310374 Staphylococcus aureus subsp. aureus MRSA252 2859910 YP_040662.1 CDS SAR1251 NC_002952.2 1310610 1312283 D Similar to Bacillus halodurans hypothetical protein BH2398 TR:Q9KA92 (EMBL:AP001515) (555 aa) fasta scores: E(): 1.1e-106, 50.090% id in 555 aa, and to Bacillus subtilis hypothetical protein YmfA TR:O31760 (EMBL:Z99112) (515 aa) fasta scores: E(): 7.4e-100, 49.320% id in 515 aa; hypothetical protein 1310610..1312283 Staphylococcus aureus subsp. aureus MRSA252 2860006 YP_040663.1 CDS SAR1252 NC_002952.2 1312540 1314909 D Similar to Bacillus subtilis stage III sporulation protein E SpoIIIE SW:SP3E_BACSU (P21458) (787 aa) fasta scores: E(): 4.6e-110, 48.111% id in 794 aa, and to Bacillus halodurans SpoIIIE protein BH2395 TR:Q9KA95 (EMBL:AP001515) (789 aa) fasta scores: E(): 2.1e-110, 47.975% id in 790 aa; DNA translocase (FtsK/SpoIIIE family protein) 1312540..1314909 Staphylococcus aureus subsp. aureus MRSA252 2860007 YP_040664.1 CDS SAR1253 NC_002952.2 1314914 1315627 D Similar to Bacillus subtilis hypothetical transcriptional regulator YmfC SW:YMFC_BACSU (O31761) (241 aa) fasta scores: E(): 2.9e-21, 34.335% id in 233 aa, and to Bacillus halodurans transcriptional regulator BH2394 TR:Q9KA96 (EMBL:AP001515) (242 aa) fasta scores: E(): 6.5e-20, 35.681% id in 213 aa; hypothetical protein 1314914..1315627 Staphylococcus aureus subsp. aureus MRSA252 2860008 YP_040665.1 CDS SAR1254 NC_002952.2 1315658 1316923 D Similar to Bacillus halodurans hypothetical protein BH2393 TR:Q9KA97 (EMBL:AP001515) (431 aa) fasta scores: E(): 2.3e-44, 34.211% id in 418 aa, and to Lactococcus lactis protease YueF TR:Q9CE72 (EMBL:AE006427) (418 aa) fasta scores: E(): 1.5e-32, 30.542% id in 406 aa; hypothetical protein 1315658..1316923 Staphylococcus aureus subsp. aureus MRSA252 2860009 YP_040666.1 CDS SAR1255 NC_002952.2 1316923 1318209 D Similar to Bacillus subtilis hypothetical protein YmfH TR:O31766 (EMBL:Z99112) (415 aa) fasta scores: E(): 1.1e-67, 46.530% id in 389 aa, and to Bacillus halodurans hypothetical protein BH2392 TR:Q9KA98 (EMBL:AP001515) (432 aa) fasta scores: E(): 2.5e-64, 42.298% id in 409 aa; protease 1316923..1318209 Staphylococcus aureus subsp. aureus MRSA252 2860010 YP_040667.1 CDS SAR1256 NC_002952.2 1318209 1318913 D Similar to Alcaligenes eutrophus acetoacetyl-CoA reductase PhbB SW:PHBB_ALCEU (P14697) (246 aa) fasta scores: E(): 1.9e-16, 31.120% id in 241 aa, and to Bacillus halodurans 3-oxoacyl-[acyl carrier protein] reductase BH2391 TR:Q9KA99 (EMBL:AP001515) (242 aa) fasta scores: E(): 8.1e-24, 35.021% id in 237 aa; short chain dehydrogenase 1318209..1318913 Staphylococcus aureus subsp. aureus MRSA252 2860011 YP_040668.1 CDS SAR1257 NC_002952.2 1319018 1319845 D Similar to Bacillus halodurans hypothetical protein BH2389 TR:Q9KAA1 (EMBL:AP001515) (257 aa) fasta scores: E(): 9.6e-57, 61.983% id in 242 aa. Internal region is similar to Bacillus subtilis hypothetical protein TR:P94509 (EMBL:U87792) (158 aa) fasta scores: E(): 5.8e-35, 70.290% id in 138 aa; hypothetical protein 1319018..1319845 Staphylococcus aureus subsp. aureus MRSA252 2860012 YP_040669.1 CDS SAR1258 NC_002952.2 1319864 1320256 D Similar to the N-terminal regions of Bacillus subtilis hypothetical protein TR:P94510 (EMBL:U87792) (307 aa) fasta scores: E(): 2e-05, 31.200% id in 125 aa, and Bacillus halodurans hypothetical protein BH2388 TR:Q9KAA2 (EMBL:AP001515) (283 aa) fasta scores: E(): 0.0014, 29.825% id in 114 aa; DNA-binding protein 1319864..1320256 Staphylococcus aureus subsp. aureus MRSA252 2860013 YP_040670.1 CDS pgsA NC_002952.2 1320290 1320868 D Similar to Bacillus subtilis CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA SW:PGSA_BACSU (P46322) (193 aa) fasta scores: E(): 5.4e-28, 48.677% id in 189 aa, and to Bacillus halodurans phosphatidylglycerophosphate synthase BH2386 TR:Q9KAA4 (EMBL:AP001515) (192 aa) fasta scores: E(): 1.7e-28, 50.000% id in 194 aa; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1320290..1320868 Staphylococcus aureus subsp. aureus MRSA252 2859901 YP_040671.1 CDS SAR1260 NC_002952.2 1321093 1322244 D Similar to Bacillus subtilis CinA-like protein CinA SW:CINA_BACSU (P46323) (416 aa) fasta scores: E(): 2e-44, 41.133% id in 406 aa, and to Bacillus halodurans competence-damage inducible protein BH2385 TR:Q9KAA5 (EMBL:AP001515) (420 aa) fasta scores: E(): 3.5e-43, 39.518% id in 415 aa; hypothetical protein 1321093..1322244 Staphylococcus aureus subsp. aureus MRSA252 2859065 YP_040672.1 CDS recA NC_002952.2 1322409 1323452 D catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1322409..1323452 Staphylococcus aureus subsp. aureus MRSA252 2859300 YP_040673.1 CDS SAR1262 NC_002952.2 1323806 1325365 D protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP; phosphodiesterase 1323806..1325365 Staphylococcus aureus subsp. aureus MRSA252 2859066 YP_040674.1 CDS SAR1263 NC_002952.2 1325661 1325831 R hypothetical protein complement(1325661..1325831) Staphylococcus aureus subsp. aureus MRSA252 2859067 YP_040675.1 CDS SAR1264 NC_002952.2 1326050 1326847 D Similar to Bacillus subtilis hypothetical protein YmdB TR:O31775 (EMBL:Z99112) (264 aa) fasta scores: E(): 5.4e-66, 65.019% id in 263 aa, and to Bacillus halodurans hypothetical protein BH2376 TR:Q9KAB3 (EMBL:AP001515) (264 aa) fasta scores: E(): 4.2e-59, 58.555% id in 263 aa; hypothetical protein 1326050..1326847 Staphylococcus aureus subsp. aureus MRSA252 2859068 YP_040676.1 CDS SAR1265 NC_002952.2 1326987 1328747 D Similar to Bacillus halodurans pyruvate synthase alpha subunit BH2374 TR:Q9KAB5 (EMBL:AP001515) (579 aa) fasta scores: E(): 1.4e-137, 63.903% id in 579 aa, and to Halobacterium sp pyruvate ferredoxin oxidoreductase alpha subunit VNG0474G TR:Q9HRZ5 (EMBL:AE005001) (582 aa) fasta scores: E(): 9.2e-80, 39.619% id in 578 aa; pyruvate flavodoxin/ferredoxin oxidoreductase 1326987..1328747 Staphylococcus aureus subsp. aureus MRSA252 2859069 YP_040677.1 CDS SAR1266 NC_002952.2 1328748 1329614 D catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta 1328748..1329614 Staphylococcus aureus subsp. aureus MRSA252 2859070 YP_040678.1 CDS SAR1267 NC_002952.2 1329709 1330002 D Similar to Bacillus halodurans hypothetical protein BH3874 TR:Q9K658 (EMBL:AP001520) (92 aa) fasta scores: E(): 6.3e-07, 30.769% id in 91 aa, and to Clostridium perfringens hypothetical protein SW:YVI2_CLOPE (Q46213) (95 aa) fasta scores: E(): 1.1e-05, 32.222% id in 90 aa; hypothetical protein 1329709..1330002 Staphylococcus aureus subsp. aureus MRSA252 2859071 YP_040679.1 CDS SAR1268 NC_002952.2 1330136 1331680 D catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 1330136..1331680 Staphylococcus aureus subsp. aureus MRSA252 2859072 YP_040680.1 CDS SAR1269 NC_002952.2 1331681 1332046 D Similar to Bacillus subtilis hypothetical protein YmcA TR:O31779 (EMBL:Z99112) (143 aa) fasta scores: E(): 6.3e-10, 33.628% id in 113 aa, and to Bacillus halodurans hypothetical protein BH2371 TR:Q9KAB8 (EMBL:AP001515) (146 aa) fasta scores: E(): 3.2e-09, 32.743% id in 113 aa; hypothetical protein 1331681..1332046 Staphylococcus aureus subsp. aureus MRSA252 2859073 YP_040681.1 CDS SAR1270 NC_002952.2 1332073 1332564 D Similar to Pyrococcus horikoshii hypothetical protein PH0159 SW:Y159_PYRHO (O57898) (162 aa) fasta scores: E(): 0.21, 29.114% id in 158 aa, and to Aeropyrum pernix hypothetical protein APE2411 TR:Q9Y974 (EMBL:AP000064) (197 aa) fasta scores: E(): 1.7e-09, 33.537% id in 164 aa; hypothetical protein 1332073..1332564 Staphylococcus aureus subsp. aureus MRSA252 2859074 YP_040682.1 CDS mutS NC_002952.2 1332867 1335485 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1332867..1335485 Staphylococcus aureus subsp. aureus MRSA252 2861327 YP_040683.1 CDS mutL NC_002952.2 1335498 1337507 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 1335498..1337507 Staphylococcus aureus subsp. aureus MRSA252 2861326 YP_040684.1 CDS glpP NC_002952.2 1337522 1338055 D Similar to Bacillus subtilis glycerol uptake operon antiterminator regulatory protein GlpP SW:GLPP_BACSU (P30300) (192 aa) fasta scores: E(): 3.1e-26, 42.614% id in 176 aa, and to Bacillus halodurans transcriptional antiterminator of glycerol uptake operon BH1091 TR:Q9KDX0 (EMBL:AP001510) (183 aa) fasta scores: E(): 7e-26, 43.503% id in 177 aa; glycerol uptake operon antiterminator regulatory protein 1337522..1338055 Staphylococcus aureus subsp. aureus MRSA252 2859927 YP_040685.1 CDS SAR1273a NC_002952.2 1338092 1338190 R Doubtful CDS. No significant database hits; hypothetical protein complement(1338092..1338190) Staphylococcus aureus subsp. aureus MRSA252 2861361 YP_040686.1 CDS glpF NC_002952.2 1338530 1339348 D Similar to Bacillus subtilis glycerol uptake facilitator protein GlpF SW:GLPF_BACSU (P18156) (274 aa) fasta scores: E(): 3.2e-55, 59.542% id in 262 aa, and to Bacillus halodurans glycerol uptake facilitator BH1092 TR:Q9KDW9 (EMBL:AP001510) (276 aa) fasta scores: E(): 1.9e-54, 60.967% id in 269 aa; glycerol uptake facilitator protein 1338530..1339348 Staphylococcus aureus subsp. aureus MRSA252 2859925 YP_040687.1 CDS glpK NC_002952.2 1339478 1340974 D Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 1339478..1340974 Staphylococcus aureus subsp. aureus MRSA252 2859926 YP_040688.1 CDS glpD NC_002952.2 1341084 1342805 D Similar to Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase GlpD SW:GLPD_BACSU (P18158) (555 aa) fasta scores: E(): 6.8e-126, 61.538% id in 546 aa, and to Bacillus halodurans glycerol-3-phosphate dehydrogenase BH1095 TR:Q9KDW6 (EMBL:AP001510) (553 aa) fasta scores: E(): 1.2e-114, 56.960% id in 546 aa. Possible alternative translational start site; aerobic glycerol-3-phosphate dehydrogenase 1341084..1342805 Staphylococcus aureus subsp. aureus MRSA252 2859924 YP_040689.1 CDS SAR1277 NC_002952.2 1342955 1343869 D Similar to Pseudomonas aeruginosa hypothetical protein PA3301 TR:Q9HYU2 (EMBL:AE004752) (316 aa) fasta scores: E(): 1.6e-25, 30.519% id in 308 aa, and to Rhizobium loti hypothetical protein MLR1612 TR:BAB48946 (EMBL:AP002997) (309 aa) fasta scores: E(): 6.4e-19, 26.871% id in 294 aa; hydrolase 1342955..1343869 Staphylococcus aureus subsp. aureus MRSA252 2861362 YP_040690.1 CDS miaA NC_002952.2 1343887 1344822 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 1343887..1344822 Staphylococcus aureus subsp. aureus MRSA252 2861164 YP_040691.1 CDS SAR1279 NC_002952.2 1344837 1345070 D Similar to Escherichia coli host factor-I for bacteriophage Q beta replication, Hfq TR:BAB38571 (EMBL:D00743) (102 aa) fasta scores: E(): 0.00013, 33.871% id in 62 aa, and to Bacillus halodurans host factor-1 protein BH2365 TR:Q9KAC4 (EMBL:AP001515) (78 aa) fasta scores: E(): 9.6e-11, 44.737% id in 76 aa; hypothetical protein 1344837..1345070 Staphylococcus aureus subsp. aureus MRSA252 2861363 YP_040692.1 CDS SAR1280 NC_002952.2 1345292 1345768 R Similar to Hordeum vulgare glutathione peroxidase TR:Q9SME4 (EMBL:AJ238745) (165 aa) fasta scores: E(): 2.8e-31, 50.955% id in 157 aa, and to Bacillus halodurans glutathione peroxidase homologue BH2830 SW:BSAA_BACHD (Q9Z9N7) (157 aa) fasta scores: E(): 5.1e-34, 57.051% id in 156 aa. Similar to SAR2699, 50.323% identity (50.323% ungapped) in 155 aa overlap; glutathione peroxidase complement(1345292..1345768) Staphylococcus aureus subsp. aureus MRSA252 2861364 YP_040693.1 CDS SAR1281 NC_002952.2 1345880 1347118 D Similar to Bacillus halodurans hypothetical protein BH2362 TR:Q9KAC7 (EMBL:AP001515) (418 aa) fasta scores: E(): 2.6e-62, 46.287% id in 404 aa, and to Streptococcus pyogenes GTP-binding protein SPY0922 TR:Q9A058 (EMBL:AE006541) (412 aa) fasta scores: E(): 6.1e-60, 44.975% id in 398 aa; hypothetical protein 1345880..1347118 Staphylococcus aureus subsp. aureus MRSA252 2861365 YP_040694.1 CDS SAR1282 NC_002952.2 1347137 1348375 D Similar to Arthrobacter viscosus aluminum resistance protein Alu-2 TR:O52647 (EMBL:AF043609) (422 aa) fasta scores: E(): 8.9e-93, 59.512% id in 410 aa, and to Bacillus subtilis hypothetical protein YnbB TR:P94479 (EMBL:U66480) (421 aa) fasta scores: E(): 7.2e-92, 60.827% id in 411 aa; hypothetical protein 1347137..1348375 Staphylococcus aureus subsp. aureus MRSA252 2861366 YP_040695.1 CDS glnR NC_002952.2 1348619 1348987 D Previously sequenced as Staphylococcus aureus glutamine synthetase repressor GlnR TR:Q53687 (EMBL:X76490) (122 aa) fasta scores: E(): 5.8e-42, 100.000% id in 122 aa. Similar to Streptococcus pyogenes transcriptional regulator SPY1878 TR:Q99Y40 (EMBL:AE006613) (123 aa) fasta scores: E(): 2.3e-12, 50.000% id in 100 aa; glutamine synthetase 1348619..1348987 Staphylococcus aureus subsp. aureus MRSA252 2859923 YP_040696.1 CDS glnA NC_002952.2 1349006 1350346 D Previously sequenced as Staphylococcus aureus glutamine synthetase GlnA SW:GLNA_STAAU (Q59812) (446 aa) fasta scores: E(): 1.8e-181, 99.776% id in 446 aa. Similar to Bacillus subtilis glutamine synthetase GlnA SW:GLNA_BACSU (P12425) (443 aa) fasta scores: E(): 4.2e-141, 76.190% id in 441 aa; glutamine synthetase 1349006..1350346 Staphylococcus aureus subsp. aureus MRSA252 2859921 YP_040697.1 CDS SAR1285 NC_002952.2 1350840 1351037 D Similar to the N-terminal region of Streptococcus thermophilus temperate bacteriophage phi O1205 hypothetical protein Orf57 TR:O34088 (EMBL:U88974) (140 aa) fasta scores: E(): 3.4, 37.500% id in 48 aa. Probable gene remnant. Similar to SAR1302, 51.562% identity (51.562% ungapped) in 64 aa overlap; hypothetical protein 1350840..1351037 Staphylococcus aureus subsp. aureus MRSA252 2861367 YP_040698.1 CDS SAR1288 NC_002952.2 1352458 1352814 R Poor database matches. Similar to hypothetical protein Bacillus subtilis YddJ TR:P96647 (EMBL:AB001488) (126 aa) fasta scores: E(): 0.027, 28.689% id in 122 aa; lipoprotein complement(1352458..1352814) Staphylococcus aureus subsp. aureus MRSA252 2861369 YP_040699.1 CDS SAR1289 NC_002952.2 1352870 1353460 R hypothetical protein complement(1352870..1353460) Staphylococcus aureus subsp. aureus MRSA252 2861370 YP_040700.1 CDS SAR1290 NC_002952.2 1353467 1354453 R Poor database matches. Similar to Staphylococcus aureus conjugative plasmid pSK41 membrane protein TraG TR:Q52271 (EMBL:AF051917) (358 aa) fasta scores: E(): 3.7e-50, 44.828% id in 348 aa; hypothetical protein complement(1353467..1354453) Staphylococcus aureus subsp. aureus MRSA252 2861371 YP_040701.1 CDS SAR1291 NC_002952.2 1354503 1356350 R Similar to Enterococcus faecalis hypothetical protein EP0024 TR:Q9F1H1 (EMBL:AE002565) (781 aa) fasta scores: E(): 1.7e-08, 22.727% id in 660 aa, and to Bacillus subtilis hypothetical protein YddG TR:P96644 (EMBL:AB001488) (815 aa) fasta scores: E(): 1.3e-06, 23.680% id in 663 aa; hypothetical protein complement(1354503..1356350) Staphylococcus aureus subsp. aureus MRSA252 2861372 YP_040702.1 CDS SAR1292 NC_002952.2 1356355 1357713 R Similar to Bacillus subtilis hypothetical protein YdcQ TR:P96634 (EMBL:AB001488) (480 aa) fasta scores: E(): 2.3e-38, 32.379% id in 454 aa, and to Enterococcus faecalis conjugative transposon Tn916 hypothetical protein Orf21 TR:Q47727 (EMBL:U09422) (461 aa) fasta scores: E(): 1.2e-32, 30.283% id in 459 aa; FtsK/SpoIIIE family protein complement(1356355..1357713) Staphylococcus aureus subsp. aureus MRSA252 2861373 YP_040703.1 CDS SAR1293 NC_002952.2 1357767 1360262 R Similar to Bacillus subtilis hypothetical protein YddE TR:P96642 (EMBL:AB001488) (831 aa) fasta scores: E(): 1.7e-121, 39.136% id in 833 aa, and to Enterococcus faecalis conjugative transposon Tn916 hypothetical protein Orf16 TR:Q47732 (EMBL:U09422) (815 aa) fasta scores: E(): 2e-17, 23.967% id in 847 aa; hypothetical protein complement(1357767..1360262) Staphylococcus aureus subsp. aureus MRSA252 2861374 YP_040704.1 CDS SAR1294 NC_002952.2 1360297 1360680 R Similar to Enterococcus faecalis conjugative transposon Tn916 hypothetical protein Orf17 TR:Q47731 (EMBL:U09422) (168 aa) fasta scores: E(): 2, 29.703% id in 101 aa, and to the N-terminus of Bacillus subtilis hypothetical protein YddD TR:P96641 (EMBL:AB001488) (174 aa) fasta scores: E(): 0.0018, 20.000% id in 130 aa; hypothetical protein complement(1360297..1360680) Staphylococcus aureus subsp. aureus MRSA252 2861375 YP_040705.1 CDS SAR1295 NC_002952.2 1360692 1360952 R Poor database matches. Similar to Bacillus subtilis hypothetical protein YddC TR:P96640 (EMBL:AB001488) (82 aa) fasta scores: E(): 0.013, 34.375% id in 64 aa; hypothetical protein complement(1360692..1360952) Staphylococcus aureus subsp. aureus MRSA252 2861376 YP_040706.1 CDS SAR1296 NC_002952.2 1360957 1362012 R Poor database matches. Similar to Bacillus subtilis YddB protein yddB TR:O31491 (EMBL:Z99106) (354 aa) fasta scores: E(): 2.5e-18, 29.480% id in 346 aa; hypothetical protein complement(1360957..1362012) Staphylococcus aureus subsp. aureus MRSA252 2861377 YP_040707.1 CDS SAR1297 NC_002952.2 1362073 1363098 R Similar to Bacillus subtilis hypothetical protein YdcR TR:P96635 (EMBL:AB001488) (352 aa) fasta scores: E(): 5.4e-42, 36.810% id in 326 aa, and to Enterococcus faecalis conjugative transposon Tn916 hypothetical protein Orf20 TR:Q47728 (EMBL:U09422) (329 aa) fasta scores: E(): 1.8e-31, 31.563% id in 339 aa; hypothetical protein complement(1362073..1363098) Staphylococcus aureus subsp. aureus MRSA252 2861378 YP_040708.1 CDS SAR1298 NC_002952.2 1363340 1363642 R hypothetical protein complement(1363340..1363642) Staphylococcus aureus subsp. aureus MRSA252 2861379 YP_040709.1 CDS SAR1299 NC_002952.2 1363656 1363976 R Similar to Bacillus subtilis hypothetical protein YdcP TR:P96633 (EMBL:AB001488) (126 aa) fasta scores: E(): 0.0019, 32.710% id in 107 aa, and to Enterococcus faecalis conjugative transposon Tn916 hypothetical protein Orf22 TR:Q47726 (EMBL:U09422) (128 aa) fasta scores: E(): 0.057, 28.440% id in 109 aa; hypothetical protein complement(1363656..1363976) Staphylococcus aureus subsp. aureus MRSA252 2861380 YP_040710.1 CDS SAR1300 NC_002952.2 1364127 1364420 R Poor database matches. Similar to Yersinia pestis plasmid pMT-1 hypothetical protein Y1103 TR:Q9ZGY2 (EMBL:AF074611) (89 aa) fasta scores: E(): 1.8, 29.730% id in 74 aa; hypothetical protein complement(1364127..1364420) Staphylococcus aureus subsp. aureus MRSA252 2861381 YP_040711.1 CDS SAR1302 NC_002952.2 1365097 1365309 D Poor database matches. Similar to Streptococcus pyogenes hypothetical protein SPY0544 TR:Q9A0Z3 (EMBL:AE006512) (69 aa) fasta scores: E(): 3.9, 33.333% id in 45 aa, and to the N-terminal region of Streptococcus thermophilus bacteriophage Sfi21 hypothetical protein Orf140b TR:O21989 (EMBL:X95646) (140 aa) fasta scores: E(): 0.48, 32.000% id in 50 aa. Similar to SAR1285, 51.562% identity (51.562% ungapped) in 64 aa overlap; hypothetical protein 1365097..1365309 Staphylococcus aureus subsp. aureus MRSA252 2861382 YP_040712.1 CDS SAR1303 NC_002952.2 1365606 1365812 D Similar to the N-terminal regions of Streptococcus thermophilus bacteriophage Sfi21 hypothetical protein Orf140b protein TR:O21989 (EMBL:X95646) (140 aa) fasta scores: E(): 1.3, 29.310% id in 58 aa, and to bacteriophage PM2 hypothetical protein TR:Q9XJS6 (EMBL:AF155037) (92 aa) fasta scores: E(): 2.9, 34.483% id in 29 aa. Similar to SAR1137, 54.545% identity (54.545% ungapped) in 66 aa overlap; hypothetical protein 1365606..1365812 Staphylococcus aureus subsp. aureus MRSA252 2861383 YP_040713.1 CDS SAR1304 NC_002952.2 1367017 1367202 D Similar to Escherichia coli O157:H7 DNA transposition protein ECS4946 TR:BAB38369 (EMBL:AP002567) (310 aa) fasta scores: E(): 0.64, 36.066% id in 61 aa, and to bacteriophage APSE-1 hypothetical protein p2 SW:VP02_BPAPS (Q9T1U6) (94 aa) fasta scores: E(): 4.9, 35.714% id in 56 aa; DNA-binding protein 1367017..1367202 Staphylococcus aureus subsp. aureus MRSA252 2861384 YP_040714.1 CDS SAR1305 NC_002952.2 1367414 1368361 R Similar to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 1.4e-126, 99.683% id in 315 aa, and to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 1.5e-70, 58.095% id in 315 aa; transposase complement(1367414..1368361) Staphylococcus aureus subsp. aureus MRSA252 2861385 YP_040715.1 CDS SAR1306 NC_002952.2 1368788 1369204 D hypothetical protein 1368788..1369204 Staphylococcus aureus subsp. aureus MRSA252 2861386 YP_040716.1 CDS SAR1311 NC_002952.2 1370725 1370976 D hypothetical protein 1370725..1370976 Staphylococcus aureus subsp. aureus MRSA252 2861388 YP_040717.1 CDS SAR1312 NC_002952.2 1371181 1371702 D Poor database matches. Similar to Bacillus anthracis plasmid pXO2 hypothetical protein pXO2-07 TR:Q9RN25 (EMBL:AF188935) (202 aa) fasta scores: E(): 5.5, 28.467% id in 137 aa. N-terminal region is similar to SAR1315, 98.462% identity (98.462% ungapped) in 65 aa overlap, SAR1318, 92.500% identity (92.500% ungapped) in 40 aa overlap, and SAR1324, 81.633% identity (83.333% ungapped) in 49 aa overlap; hypothetical protein 1371181..1371702 Staphylococcus aureus subsp. aureus MRSA252 2861389 YP_040718.1 CDS SAR1313 NC_002952.2 1371704 1371901 D Poor database matches. Similar to the N-terminal region of Schizosaccharomyces pombe hypothetical protein SPBC23G7.01c TR:O94752 (EMBL:AL035077) (454 aa) fasta scores: E(): 1.4, 35.938% id in 64 aa. Similar to SAR1317, 50.820% identity (50.820% ungapped) in 61 aa overlap; hypothetical protein 1371704..1371901 Staphylococcus aureus subsp. aureus MRSA252 2861390 YP_040719.1 CDS SAR1314 NC_002952.2 1372328 1372645 D No significant database matches. C-terminal region is similar to SAR1322, 53.125% identity (54.255% ungapped) in 96 aa overlap. N-terminus is similar to C-terminal region of SAR1321, 92.453% identity (92.453% ungapped) in 53 aa overlap. Possible alternative translational start; hypothetical protein 1372328..1372645 Staphylococcus aureus subsp. aureus MRSA252 2861391 YP_040720.1 CDS SAR1315 NC_002952.2 1372972 1373169 D Poor database matches. Similar to internal region of bacteriophage TP901-1 hypothetical protein Orf33 TR:Q9AZ64 (EMBL:AF304433) (564 aa) fasta scores: E(): 0.0027, 35.821% id in 67 aa. Similar to SAR1312, 98.462% identity (98.462% ungapped) in 65 aa overlap, SAR1318, 92.500% identity (92.500% ungapped) in 40 aa overlap, and SAR1324, 81.633% identity (83.333% ungapped) in 49 aa overlap; hypothetical protein 1372972..1373169 Staphylococcus aureus subsp. aureus MRSA252 2861392 YP_040721.1 CDS SAR1316 NC_002952.2 1373314 1373487 D hypothetical protein 1373314..1373487 Staphylococcus aureus subsp. aureus MRSA252 2861393 YP_040722.1 CDS SAR1317 NC_002952.2 1373498 1373692 D No significant database matches. Similar to SAR1313, 50.820% identity (50.820% ungapped) in 61 aa overlap; hypothetical protein 1373498..1373692 Staphylococcus aureus subsp. aureus MRSA252 2861394 YP_040723.1 CDS SAR1318 NC_002952.2 1373905 1374138 D Poor database matches. Similar to an internal region of bacteriophage hypothetical protein TP901-1 Orf33 TR:Q9AZ64 (EMBL:AF304433) (564 aa) fasta scores: E(): 0.017, 35.526% id in 76 aa. Similar to SAR1315, 92.500% identity (92.500% ungapped) in 40 aa overlap, SAR1312, 92.500% identity (92.500% ungapped) in 40 aa overlap, and SAR1324, 83.333% identity (83.333% ungapped) in 42 aa overlap; hypothetical protein 1373905..1374138 Staphylococcus aureus subsp. aureus MRSA252 2861395 YP_040724.1 CDS SAR1319 NC_002952.2 1374311 1374436 D hypothetical protein 1374311..1374436 Staphylococcus aureus subsp. aureus MRSA252 2861396 YP_040725.1 CDS SAR1320 NC_002952.2 1374449 1374697 D hypothetical protein 1374449..1374697 Staphylococcus aureus subsp. aureus MRSA252 2861397 YP_040726.1 CDS SAR1321 NC_002952.2 1374848 1375126 D Poor database matches. Similar to the N-terminal region of Mycobacteriophage TM4 hypothetical protein gp8 TR:Q9ZX69 (EMBL:AF068845) (186 aa) fasta scores: E(): 3, 36.250% id in 80 aa; hypothetical protein 1374848..1375126 Staphylococcus aureus subsp. aureus MRSA252 2858928 YP_040727.1 CDS SAR1322 NC_002952.2 1375139 1375438 D Poor database matches. Similar to internal region of Human rotavirus hypothetical protein VP3 TR:Q9IPG6 (EMBL:AB045215) (162 aa) fasta scores: E(): 4.9, 30.667% id in 75 aa. C-terminus is similar to the N-terminal region of SAR1314, 92.453% identity (92.453% ungapped) in 53 aa overlap; hypothetical protein 1375139..1375438 Staphylococcus aureus subsp. aureus MRSA252 2858929 YP_040728.1 CDS SAR1323 NC_002952.2 1375435 1375572 D hypothetical protein 1375435..1375572 Staphylococcus aureus subsp. aureus MRSA252 2858930 YP_040729.1 CDS SAR1324 NC_002952.2 1375775 1375975 D Poor database matches. Similar to C-terminal region of Lactococcus lactis bacteriophage Tuc2009 hypothetical protein TR:Q9AYW9 (EMBL:AF109874) (346 aa) fasta scores: E(): 0.39, 39.216% id in 51 aa. Similar to SAR1315, 81.633% identity (83.333% ungapped) in 49 aa overlap, SAR1318, 83.333% identity (83.333% ungapped) in 42 aa overlap, and to the N-terminal region of SAR1312, 81.633% identity (83.333% ungapped) in 49 aa overlap; hypothetical protein 1375775..1375975 Staphylococcus aureus subsp. aureus MRSA252 2858931 YP_040730.1 CDS SAR1325 NC_002952.2 1375982 1376179 D Poor database matches. Similar to internal region of Ureaplasma parvum hypothetical protein UU376 SW:Y376_UREPA (Q9PQB5) (242 aa) fasta scores: E(): 3.4, 38.095% id in 63 aa; hypothetical protein 1375982..1376179 Staphylococcus aureus subsp. aureus MRSA252 2858932 YP_040731.1 CDS SAR1325b NC_002952.2 1376455 1376565 D hypothetical protein 1376455..1376565 Staphylococcus aureus subsp. aureus MRSA252 2858933 YP_040732.1 CDS SAR1326 NC_002952.2 1376726 1377751 R C-terminal region is similar to an internal region of Ashbya gossypii threonine aldolase Gly1 SW:GLY1_ASHGO (O74267) (382 aa) fasta scores: E(): 0.001, 23.183% id in 289 aa. Similar to Leishmania major hypothetical protein L4171.5 l4171.5 TR:O15839 (EMBL:AE001274) (359 aa) fasta scores: E(): 8e-48, 41.888% id in 339 aa; hypothetical protein complement(1376726..1377751) Staphylococcus aureus subsp. aureus MRSA252 2858934 YP_040733.1 CDS SAR1327 NC_002952.2 1378021 1378218 D hypothetical protein 1378021..1378218 Staphylococcus aureus subsp. aureus MRSA252 2858935 YP_040734.1 CDS SAR1328 NC_002952.2 1378275 1379756 D Similar to Lactococcus lactis cardiolipin synthase ClsB TR:Q9CGC3 (EMBL:AE006349) (487 aa) fasta scores: E(): 4.4e-67, 42.169% id in 498 aa, and to Bacillus subtilis probable cardiolipin synthetase 2 YwnE SW:CLS2_BACSU (P71040) (482 aa) fasta scores: E(): 9.6e-94, 50.000% id in 484 aa. Similar to SAR2177, 55.556% identity (56.144% ungapped) in 477 aa overlap; cardiolipin synthase 1378275..1379756 Staphylococcus aureus subsp. aureus MRSA252 2858936 YP_040735.1 CDS SAR1329 NC_002952.2 1379930 1380838 D Similar to Bacillus subtilis hypothetical protein YvfR TR:O07016 (EMBL:Z94043) (301 aa) fasta scores: E(): 3.5e-21, 33.217% id in 286 aa, and to Bacillus licheniformis ABC transporter ATP binding subunit YvfR TR:Q9F5X5 (EMBL:AF302051) (299 aa) fasta scores: E(): 3.2e-17, 28.767% id in 292 aa; ABC transporter ATP-binding protein 1379930..1380838 Staphylococcus aureus subsp. aureus MRSA252 2858937 YP_040736.1 CDS SAR1330 NC_002952.2 1380807 1381538 D Similar to Bacillus cereus hypothetical protein YvfS TR:Q9L4F5 (EMBL:AJ243712) (239 aa) fasta scores: E(): 3.6e-20, 30.802% id in 237 aa, and to Bacillus subtilis hypothetical protein YvfS TR:O07017 (EMBL:Z94043) (245 aa) fasta scores: E(): 3.1e-17, 25.114% id in 219 aa; hypothetical protein 1380807..1381538 Staphylococcus aureus subsp. aureus MRSA252 2858938 YP_040737.1 CDS SAR1331 NC_002952.2 1381542 1382633 D Two-component regulatory system family, sensor kinase. Similar to Salmonella typhimurium sensor protein UhpB SW:UHPB_SALTY (P27668) (500 aa) fasta scores: E(): 7.9e-06, 21.607% id in 361 aa, and to Bacillus cereus two-component sensor histidine kinase YvfT TR:Q9L4F4 (EMBL:AJ243712) (376 aa) fasta scores: E(): 1.5e-21, 29.178% id in 353 aa; sensor kinase 1381542..1382633 Staphylococcus aureus subsp. aureus MRSA252 2858939 YP_040738.1 CDS SAR1332 NC_002952.2 1382630 1383136 D Possible pseudogene. Two-component regulatory system family, response regulator protein. Similar to Streptococcus pneumoniae response regulator SP2000 TR:Q9S1I7 (EMBL:AJ006400) (199 aa) fasta scores: E(): 1.1e-20, 42.714% id in 199 aa, and to Bacillus halodurans two-component response regulator BH0581 TR:Q9KFA4 (EMBL:AP001509) (201 aa) fasta scores: E(): 7.5e-18, 42.289% id in 201 aa. CDS is smaller than other homologues, contains and internal deletion of approximately 30 amino acids.; response regulator 1382630..1383136 Staphylococcus aureus subsp. aureus MRSA252 2858940 YP_040739.1 CDS SAR1333 NC_002952.2 1383249 1383437 R hypothetical protein complement(1383249..1383437) Staphylococcus aureus subsp. aureus MRSA252 2858941 YP_040740.1 CDS nucI NC_002952.2 1383576 1384109 D Similar to Staphylococcus intermedius thermonuclease precursor NucI SW:NUC_STAIN (P43269) (168 aa) fasta scores: E(): 7.2e-32, 54.070% id in 172 aa, and to Staphylococcus hyicus thermonuclease precursor NucH SW:NUC_STAHY (P43270) (169 aa) fasta scores: E(): 1.9e-30, 53.672% id in 177 aa; thermonuclease 1383576..1384109 Staphylococcus aureus subsp. aureus MRSA252 2859169 YP_040741.1 CDS SAR1335 NC_002952.2 1384252 1385106 R hypothetical protein complement(1384252..1385106) Staphylococcus aureus subsp. aureus MRSA252 2858942 YP_040742.1 CDS SAR1336 NC_002952.2 1385422 1386012 D hypothetical protein 1385422..1386012 Staphylococcus aureus subsp. aureus MRSA252 2858943 YP_040743.1 CDS SAR1337 NC_002952.2 1386066 1387460 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase complement(1386066..1387460) Staphylococcus aureus subsp. aureus MRSA252 2858944 YP_040744.1 CDS SAR1338 NC_002952.2 1387639 1388919 D catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1387639..1388919 Staphylococcus aureus subsp. aureus MRSA252 2858945 YP_040745.1 CDS thrC NC_002952.2 1388925 1389986 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1388925..1389986 Staphylococcus aureus subsp. aureus MRSA252 2859531 YP_040746.1 CDS thrB NC_002952.2 1389988 1390902 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1389988..1390902 Staphylococcus aureus subsp. aureus MRSA252 2859530 YP_040747.1 CDS SAR1341 NC_002952.2 1390960 1391763 D Similar to Vibrio cholerae hypothetical protein VC1364 TR:Q9KS95 (EMBL:AE004216) (273 aa) fasta scores: E(): 6.4e-22, 33.459% id in 266 aa, and to Lactococcus lactis hypothetical protein YkiF TR:Q9CGM1 (EMBL:AE006340) (271 aa) fasta scores: E(): 1.1e-20, 31.461% id in 267 aa; haloacid dehalogenase-like hydrolase 1390960..1391763 Staphylococcus aureus subsp. aureus MRSA252 2858946 YP_040748.1 CDS SAR1342 NC_002952.2 1392055 1392369 R hypothetical protein complement(1392055..1392369) Staphylococcus aureus subsp. aureus MRSA252 2858947 YP_040749.1 CDS SAR1343 NC_002952.2 1392588 1394042 R Similar to Escherichia coli lysine-specific permease LysP SW:LYSP_ECOLI (P25737) (488 aa) fasta scores: E(): 2.3e-76, 45.720% id in 479 aa, and to Lactococcus lactis lysine specific permease LysP TR:Q9CDM6 (EMBL:AE006448) (506 aa) fasta scores: E(): 1.4e-74, 44.650% id in 486 aa; amino acid permease complement(1392588..1394042) Staphylococcus aureus subsp. aureus MRSA252 2858948 YP_040750.1 CDS SAR1344 NC_002952.2 1394246 1395763 D Previously sequenced as Staphylococcus aureus subsp. anaerobius catalase TR:Q9L4S1 (EMBL:AJ000472) (505 aa) fasta scores: E(): 8.4e-210, 99.208% id in 505 aa. Similar to Staphylococcus warneri catalase TR:Q9KW19 (EMBL:AB045340) (505 aa) fasta scores: E(): 4.1e-195, 90.476% id in 504 aa; catalase 1394246..1395763 Staphylococcus aureus subsp. aureus MRSA252 2858949 YP_040751.1 CDS rpmG NC_002952.2 1395854 1396003 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1395854..1396003 Staphylococcus aureus subsp. aureus MRSA252 2860163 YP_040752.1 CDS rpsN NC_002952.2 1396457 1396726 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 1396457..1396726 Staphylococcus aureus subsp. aureus MRSA252 2858950 YP_040753.1 CDS SAR1347 NC_002952.2 1396883 1397860 D Similar to Ascaris suum GMP reductase SW:GUAC_ASCSU (P27442) (356 aa) fasta scores: E(): 2.8e-26, 33.846% id in 325 aa, and to Bacillus subtilis hypothetical protein YumD TR:O05269 (EMBL:Z93939) (326 aa) fasta scores: E(): 2.6e-94, 77.019% id in 322 aa; guanosine 5'-monophosphate oxidoreductase 1396883..1397860 Staphylococcus aureus subsp. aureus MRSA252 2858951 YP_040754.1 CDS SAR1348 NC_002952.2 1398035 1398898 D Poor database matches. Similar to Bacillus subtilis hypothetical protein YlbC TR:O34586 (EMBL:Z99111) (346 aa) fasta scores: E(): 5.7e-11, 29.474% id in 285 aa, and to Bacillus halodurans hypothetical protein BH2604 TR:Q9K9P1 (EMBL:AP001516) (363 aa) fasta scores: E(): 1.3e-08, 27.632% id in 304 aa; hypothetical protein 1398035..1398898 Staphylococcus aureus subsp. aureus MRSA252 2858952 YP_040755.1 CDS dinR NC_002952.2 1399278 1399901 R Represses a number of genes involved in the response to DNA damage; LexA repressor complement(1399278..1399901) Staphylococcus aureus subsp. aureus MRSA252 2859592 YP_040756.1 CDS SAR1350 NC_002952.2 1400041 1400277 D hypothetical protein 1400041..1400277 Staphylococcus aureus subsp. aureus MRSA252 2858953 YP_040757.1 CDS SAR1351 NC_002952.2 1400413 1400652 D Similar to Lactococcus lactis hypothetical protein YlaC TR:Q9CGJ9 (EMBL:AE006342) (80 aa) fasta scores: E(): 2.4e-09, 48.750% id in 80 aa, and to Streptococcus pyogenes hypothetical protein SPY1687 TR:Q99YI5 (EMBL:AE006599) (85 aa) fasta scores: E(): 2.6e-09, 54.412% id in 68 aa; hypothetical protein 1400413..1400652 Staphylococcus aureus subsp. aureus MRSA252 2858954 YP_040758.1 CDS SAR1352 NC_002952.2 1400773 1402761 D Similar to Craterostigma plantagineum transketolase 10 TKT10 SW:TKTA_CRAPL (Q42675) (679 aa) fasta scores: E(): 6.6e-118, 48.402% id in 657 aa, and to Bacillus subtilis transketolase Tkt SW:TKT_BACSU (P45694) (667 aa) fasta scores: E(): 3.2e-159, 61.061% id in 660 aa; transketolase 1400773..1402761 Staphylococcus aureus subsp. aureus MRSA252 2858955 YP_040759.1 CDS SAR1353 NC_002952.2 1403039 1403281 D Similar to Bacillus subtilis hypothetical protein YneF SW:YNEF_BACSU (P45708) (72 aa) fasta scores: E(): 6.2e-15, 70.588% id in 68 aa, and to Bacillus halodurans hypothetical protein BH2350 SW:YN50_BACHD (Q9KAD9) (72 aa) fasta scores: E(): 3.3e-13, 58.571% id in 70 aa; hypothetical protein 1403039..1403281 Staphylococcus aureus subsp. aureus MRSA252 2858956 YP_040760.1 CDS SAR1355 NC_002952.2 1403460 1403927 D Similar to Bacillus subtilis hypothetical protein required for cytochrome c synthesis, CcdC SW:CCDC_BACSU (P45710) (160 aa) fasta scores: E(): 1e-30, 56.579% id in 152 aa, and to Bacillus halodurans hypothetical protein BH2333 TR:Q9KAF4 (EMBL:AP001515) (169 aa) fasta scores: E(): 4e-29, 53.642% id in 151 aa; hypothetical protein 1403460..1403927 Staphylococcus aureus subsp. aureus MRSA252 2858957 YP_040761.1 CDS SAR1356 NC_002952.2 1404051 1405172 D Similar to Escherichia coli ATP-dependent dsDNA exonuclease SbcD SW:SBCD_ECOLI (P13457) (400 aa) fasta scores: E(): 0.00012, 23.929% id in 397 aa, and to Vibrio cholerae exonuclease VCA520 TR:Q9KM68 (EMBL:AE004382) (379 aa) fasta scores: E(): 8e-39, 33.780% id in 373 aa; exonuclease 1404051..1405172 Staphylococcus aureus subsp. aureus MRSA252 2858958 YP_040762.1 CDS SAR1357 NC_002952.2 1405176 1408205 D Similar to Escherichia coli ATP-dependent dsDNA exonuclease SbcC SW:SBCC_ECOLI (P13458) (1048 aa) fasta scores: E(): 1.1e-10, 22.120% id in 1085 aa, and to Vibrio cholerae exonuclease VCA0521 TR:Q9KM67 (EMBL:AE004382) (1013 aa) fasta scores: E(): 1e-38, 26.839% id in 1047 aa. Contains coiled-coiled domains; exonuclease 1405176..1408205 Staphylococcus aureus subsp. aureus MRSA252 2858959 YP_040763.1 CDS SAR1358 NC_002952.2 1408278 1409033 D C-terminal region is similar to Lactobacillus johnsonii insertion element IS1223 hypothetical protein SW:YI3A_LACJO (Q48585) (177 aa) fasta scores: E(): 2.7e-08, 33.140% id in 172 aa, and Lactococcus lactis hypothetical protein YgcE TR:O32786 (EMBL:X92946) (185 aa) fasta scores: E(): 7.2e-06, 26.404% id in 178 aa; insertion element protein 1408278..1409033 Staphylococcus aureus subsp. aureus MRSA252 2858960 YP_040764.1 CDS SAR1359 NC_002952.2 1409057 1409845 D Similar to the C-terminal region of Enterococcus faecium transposase TR:Q47815 (EMBL:L40841) (310 aa) fasta scores: E(): 1.9e-39, 46.183% id in 262 aa, and to the full length Klebsiella pneumoniae hypothetical protein TR:Q9AG21 (EMBL:AF345899) (281 aa) fasta scores: E(): 3e-27, 37.308% id in 260 aa; transposase 1409057..1409845 Staphylococcus aureus subsp. aureus MRSA252 2858961 YP_040765.1 CDS mscL NC_002952.2 1409939 1410301 R forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel complement(1409939..1410301) Staphylococcus aureus subsp. aureus MRSA252 2861312 YP_040766.1 CDS opuD1 NC_002952.2 1410505 1412151 D Similar to Bacillus subtilis glycine betaine transporter OpuD SW:OPUD_BACSU (P54417) (512 aa) fasta scores: E(): 2.3e-109, 56.048% id in 496 aa, and to Listeria monocytogenes glycine betaine transporter BetL TR:Q9X4A5 (EMBL:AF102174) (507 aa) fasta scores: E(): 1.7e-106, 56.126% id in 506 aa; glycine betaine transporter 1 1410505..1412151 Staphylococcus aureus subsp. aureus MRSA252 2861469 YP_040767.1 CDS citB NC_002952.2 1412719 1415424 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1412719..1415424 Staphylococcus aureus subsp. aureus MRSA252 2861357 YP_040768.1 CDS SAR1363 NC_002952.2 1415605 1416072 D Similar to Bacillus halodurans hypothetical protein BH2288 TR:Q9KAJ9 (EMBL:AP001515) (143 aa) fasta scores: E(): 1.3e-27, 51.128% id in 133 aa, and to Bacillus subtilis hypothetical protein YneP TR:Q45061 (EMBL:Z73234) (121 aa) fasta scores: E(): 4.2e-23, 47.500% id in 120 aa; hypothetical protein 1415605..1416072 Staphylococcus aureus subsp. aureus MRSA252 2858962 YP_040769.1 CDS SAR1364 NC_002952.2 1416281 1416577 R Similar to Bacillus halodurans hypothetical protein BH2252 TR:Q9KAN5 (EMBL:AP001514) (95 aa) fasta scores: E(): 1.5e-07, 37.500% id in 96 aa, and to Bacillus subtilis hypothetical protein YneR TR:Q45063 (EMBL:Z73234) (95 aa) fasta scores: E(): 4.6e-07, 34.409% id in 93 aa; hypothetical protein complement(1416281..1416577) Staphylococcus aureus subsp. aureus MRSA252 2858963 YP_040770.1 CDS SAR1365 NC_002952.2 1416955 1417563 R Similar to Lactococcus lactis hypothetical protein YkaC TR:Q9CGW4 (EMBL:AE006332) (213 aa) fasta scores: E(): 4.6e-25, 42.500% id in 200 aa, and to Streptococcus pyogenes hypothetical protein SPY0908 TR:Q9A070 (EMBL:AE006539) (213 aa) fasta scores: E(): 6.8e-22, 40.952% id in 210 aa; hypothetical protein complement(1416955..1417563) Staphylococcus aureus subsp. aureus MRSA252 2858964 YP_040771.1 CDS grlB NC_002952.2 1417763 1419760 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1417763..1419760 Staphylococcus aureus subsp. aureus MRSA252 2859942 YP_040772.1 CDS grlA NC_002952.2 1419760 1422162 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 1419760..1422162 Staphylococcus aureus subsp. aureus MRSA252 2859941 YP_040773.1 CDS SAR1368 NC_002952.2 1422412 1423872 D Similar to Bacillus halodurans amino acid carrier protein BH1772 TR:Q9KC02 (EMBL:AP001513) (481 aa) fasta scores: E(): 1.1e-90, 53.347% id in 478 aa, and to Bacillus subtilis amino acid carrier protein AlsT SW:ALST_BACSU (Q45068) (465 aa) fasta scores: E(): 4e-90, 53.277% id in 473 aa; sodium:alanine symporter family protein 1422412..1423872 Staphylococcus aureus subsp. aureus MRSA252 2858965 YP_040774.1 CDS SAR1369 NC_002952.2 1424372 1425223 D Similar to Bacillus subtilis transcription antiterminator LicT SW:LICT_BACSU (P39805) (277 aa) fasta scores: E(): 1.4e-22, 31.502% id in 273 aa, and to Staphylococcus carnosus antiterminator GlcT TR:O33618 (EMBL:Y14029) (287 aa) fasta scores: E(): 1.3e-59, 58.363% id in 281 aa; transcription antiterminator 1424372..1425223 Staphylococcus aureus subsp. aureus MRSA252 2861431 YP_040775.1 CDS SAR1370 NC_002952.2 1425270 1425365 D Doubtful CDS. No significant database matches; hypothetical protein 1425270..1425365 Staphylococcus aureus subsp. aureus MRSA252 2861432 YP_040776.1 CDS SAR1371 NC_002952.2 1425358 1426566 D Similar to Bacillus subtilis hypothetical protein YubA SW:YUBA_BACSU (O32086) (388 aa) fasta scores: E(): 1.6e-59, 45.119% id in 379 aa, and to Bacillus subtilis hypothetical protein YueF SW:YUEF_BACSU (O32095) (369 aa) fasta scores: E(): 1.4e-41, 33.520% id in 358 aa; hypothetical protein 1425358..1426566 Staphylococcus aureus subsp. aureus MRSA252 2861433 YP_040777.1 CDS mprF NC_002952.2 1427047 1429569 D Similar to Staphylococcus aureus membrane protein MprF TR:AAK58115 (EMBL:AF145699) (840 aa) fasta scores: E(): 0, 96.190% id in 840 aa. Similar to Staphylococcus xylosus membrane protein MprF TR:AAK58113 (EMBL:AF145698) (841 aa) fasta scores: E(): 5.4e-208, 62.530% id in 838 aa. Mutations in the CDS have reduced resistance to human defensins and evasion of neutrophil killing; hypothetical protein 1427047..1429569 Staphylococcus aureus subsp. aureus MRSA252 2861306 YP_040778.1 CDS msrA1 NC_002952.2 1429772 1430281 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(1429772..1430281) Staphylococcus aureus subsp. aureus MRSA252 2861313 YP_040779.1 CDS SAR1374 NC_002952.2 1430418 1431401 D Similar to Enterococcus faecalis hypothetical protein Psr TR:Q9K2N9 (EMBL:AJ276232) (390 aa) fasta scores: E(): 5.5e-42, 41.801% id in 311 aa, and to Enterococcus hirae hypothetical protein Psr TR:Q47828 (EMBL:U42211) (293 aa) fasta scores: E(): 2.8e-37, 39.274% id in 303 aa; hypothetical protein 1430418..1431401 Staphylococcus aureus subsp. aureus MRSA252 2861434 YP_040780.1 CDS SAR1375 NC_002952.2 1431432 1433078 R Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 9.8e-199, 99.453% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 3.5e-99, 52.115% id in 520 aa; transposase complement(1431432..1433078) Staphylococcus aureus subsp. aureus MRSA252 2861435 YP_040781.1 CDS SAR1376 NC_002952.2 1433402 1433590 R Similar to Pseudomonas putida 4-oxalocrotonate tautomerase XylH SW:XYLH_PSEPU (Q01468) (62 aa) fasta scores: E(): 6.6e-06, 40.741% id in 54 aa, and to Bacillus halodurans 4-oxalocrotonate tautomerase BH3814 TR:Q9K6B5 (EMBL:AP001520) (61 aa) fasta scores: E(): 9e-12, 65.574% id in 61 aa; 4-oxalocrotonate tautomerase complement(1433402..1433590) Staphylococcus aureus subsp. aureus MRSA252 2861436 YP_040782.1 CDS SAR1377 NC_002952.2 1433735 1434997 D Similar to Bacillus anthracis plasmid pXO2 hypothetical protein pXO2-69 TR:Q9RMW5 (EMBL:AF188935) (421 aa) fasta scores: E(): 1.1e-87, 50.594% id in 421 aa, and to bacteriophage SPBc2 ImpB/MucB/SamB family protein YolE TR:O64031 (EMBL:AF020713) (416 aa) fasta scores: E(): 2.1e-68, 44.787% id in 422 aa; ImpB/MucB/SamB family protein 1433735..1434997 Staphylococcus aureus subsp. aureus MRSA252 2861437 YP_040783.1 CDS SAR1378 NC_002952.2 1435133 1436224 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(1435133..1436224) Staphylococcus aureus subsp. aureus MRSA252 2861438 YP_040784.1 CDS SAR1379 NC_002952.2 1436389 1437420 D Similar to Lactococcus lactis glutamyl-aminopeptidase PepA SW:PEPA_LACLC (Q48677) (355 aa) fasta scores: E(): 6.1e-10, 24.294% id in 354 aa, and to Bacillus subtilis hypothetical protein YhfE TR:O07603 (EMBL:Y14083) (346 aa) fasta scores: E(): 3.2e-79, 60.947% id in 338 aa; peptidase 1436389..1437420 Staphylococcus aureus subsp. aureus MRSA252 2861439 YP_040785.1 CDS trpE NC_002952.2 1437913 1439319 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1437913..1439319 Staphylococcus aureus subsp. aureus MRSA252 2860401 YP_040786.1 CDS trpG NC_002952.2 1439316 1439882 D Similar to Lactococcus lactis anthranilate synthase component II TrpG SW:TRPG_LACLA (Q02003) (198 aa) fasta scores: E(): 3.7e-23, 42.188% id in 192 aa, and to Streptococcus pyogenes anthranilate synthase component II SPY1991 TR:Q99XW5 (EMBL:AE006622) (188 aa) fasta scores: E(): 4.1e-24, 38.542% id in 192 aa; anthranilate synthase component II 1439316..1439882 Staphylococcus aureus subsp. aureus MRSA252 2860403 YP_040787.1 CDS trpC NC_002952.2 1440886 1441668 D involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 1440886..1441668 Staphylococcus aureus subsp. aureus MRSA252 2860399 YP_040788.1 CDS trpF NC_002952.2 1441668 1442300 D catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 1441668..1442300 Staphylococcus aureus subsp. aureus MRSA252 2860402 YP_040789.1 CDS trpB NC_002952.2 1442293 1443507 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1442293..1443507 Staphylococcus aureus subsp. aureus MRSA252 2860398 YP_040790.1 CDS trpA NC_002952.2 1443500 1444228 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1443500..1444228 Staphylococcus aureus subsp. aureus MRSA252 2860397 YP_040791.1 CDS femA NC_002952.2 1444550 1445812 D Previously sequenced as Staphylococcus aureus factor essential for expression of methicillin resistance FemA SW:FEMA_STAAU (P14304) (433 aa) fasta scores: E(): 2e-155, 99.524% id in 420 aa. Similar to Staphylococcus epidermidis FemA TR:P95734 (EMBL:U23713) (422 aa) fasta scores: E(): 6.5e-130, 81.490% id in 416 aa; factor essential for expression of methicillin resistance 1444550..1445812 Staphylococcus aureus subsp. aureus MRSA252 2860660 YP_040792.1 CDS femB NC_002952.2 1445831 1447090 D Similar to Staphylococcus aureus possible protein FemB SW:FEMB_STAAU (P14305) (419 aa) fasta scores: E(): 1.5e-161, 100.000% id in 419 aa, and to Staphylococcus epidermidis FemB TR:P95735 (EMBL:U23714) (417 aa) fasta scores: E(): 2.9e-141, 86.158% id in 419 aa; methicillin resistance expression factor 1445831..1447090 Staphylococcus aureus subsp. aureus MRSA252 2860661 YP_040793.1 CDS SAR1391 NC_002952.2 1448569 1449027 R hypothetical protein complement(1448569..1449027) Staphylococcus aureus subsp. aureus MRSA252 2861441 YP_040794.1 CDS SAR1392 NC_002952.2 1449150 1449851 R Previously sequenced as Staphylococcus aureus oligopeptide transporter ATPase Opp-2F TR:Q9ZGN3 (EMBL:AF076684) (233 aa) fasta scores: E(): 1.3e-77, 99.142% id in 233 aa. Similar to Chlamydia trachomatis oligopeptide transport ATPase CT202 TR:O84205 (EMBL:AE001293) (247 aa) fasta scores: E(): 3.9e-16, 30.833% id in 240 aa; oligopeptide transporter ATPase complement(1449150..1449851) Staphylococcus aureus subsp. aureus MRSA252 2861442 YP_040795.1 CDS SAR1393 NC_002952.2 1449844 1450617 R Previously sequenced as Staphylococcus aureus oligopeptide transporter ATPase Opp-2D TR:Q9ZGN4 (EMBL:AF076684) (258 aa) fasta scores: E(): 4.5e-88, 96.887% id in 257 aa. Similar to Chlamydia pneumoniae oligopeptide transport ATPase CPN0201 TR:Q9Z8Y3 (EMBL:AE001606) (284 aa) fasta scores: E(): 1e-23, 35.547% id in 256 aa; oligopeptide transporter ATPase complement(1449844..1450617) Staphylococcus aureus subsp. aureus MRSA252 2861443 YP_040796.1 CDS SAR1394 NC_002952.2 1450604 1451434 R Similar to Escherichia coli dipeptide ABC transporter permease DppC SW:DPPC_ECOLI (P37315) (300 aa) fasta scores: E(): 2e-28, 33.333% id in 273 aa. Previously sequenced as Staphylococcus aureus oligopeptide transporter membrane permease Opp-2C TR:Q9ZGN5 (EMBL:AF076684) (276 aa) fasta scores: E(): 4.9e-102, 98.188% id in 276 aa; oligopeptide ABC transporter permease complement(1450604..1451434) Staphylococcus aureus subsp. aureus MRSA252 2861444 YP_040797.1 CDS SAR1395 NC_002952.2 1451427 1452413 R Similar to Escherichia coli nickel ABC transporter permease NikB SW:NIKB_ECOLI (P33591) (314 aa) fasta scores: E(): 2.4e-30, 32.797% id in 311 aa. Previously sequenced as Staphylococcus aureus oligopeptide transporter membrane permease Opp-2B TR:Q9ZGN6 (EMBL:AF076684) (328 aa) fasta scores: E(): 1.2e-115, 97.256% id in 328 aa; oligopeptide ABC transporter permease complement(1451427..1452413) Staphylococcus aureus subsp. aureus MRSA252 2861445 YP_040798.1 CDS SAR1396 NC_002952.2 1452717 1453061 R Poor database matches. Weakly similar to the C-terminal region of Vibrio cholerae hypothetical protein VC2101 TR:Q9KQ99 (EMBL:AE004284) (146 aa) fasta scores: E(): 4.4, 26.214% id in 103 aa; hypothetical protein complement(1452717..1453061) Staphylococcus aureus subsp. aureus MRSA252 2861152 YP_040799.1 CDS SAR1397 NC_002952.2 1453266 1455080 D Similar to Lactococcus lactis plasmid pLP763 oligoendopeptidase F PepF SW:PEF1_LACLC (P54124) (601 aa) fasta scores: E(): 5.7e-39, 23.786% id in 597 aa, and to Streptococcus pyogenes oligopeptidase SPY0606 TR:Q9A0U8 (EMBL:AE006515) (599 aa) fasta scores: E(): 3.7e-91, 42.070% id in 599 aa; peptidase 1453266..1455080 Staphylococcus aureus subsp. aureus MRSA252 2860183 YP_040800.1 CDS SAR1398 NC_002952.2 1455220 1455861 R Similar to Escherichia coli phosphate transporter PhoU SW:PHOU_ECOLI (P07656) (241 aa) fasta scores: E(): 8.9e-14, 28.241% id in 216 aa, and to Rhizobium meliloti phosphate transporter SMC02141 SW:PHOU_RHIME (Q52989) (237 aa) fasta scores: E(): 5e-15, 30.233% id in 215 aa; phosphate transporter complement(1455220..1455861) Staphylococcus aureus subsp. aureus MRSA252 2860184 YP_040801.1 CDS SAR1399 NC_002952.2 1455868 1456719 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1455868..1456719) Staphylococcus aureus subsp. aureus MRSA252 2860185 YP_040802.1 CDS SAR1400 NC_002952.2 1456766 1457683 R Similar to Escherichia coli phosphate ABC transporter permease PstA SW:PSTA_ECOLI (P07654) (296 aa) fasta scores: E(): 7.7e-23, 31.707% id in 287 aa, and to Bacillus halodurans phosphate ABC transporter BH2992 TR:Q9K8L4 (EMBL:AP001517) (294 aa) fasta scores: E(): 1e-55, 52.703% id in 296 aa; ABC transporter permease complement(1456766..1457683) Staphylococcus aureus subsp. aureus MRSA252 2860186 YP_040803.1 CDS SAR1401 NC_002952.2 1457685 1458611 R Similar to Bacillus halodurans phosphate ABC transporter BH2993 TR:Q9K8L3 (EMBL:AP001517) (318 aa) fasta scores: E(): 2.1e-64, 61.564% id in 307 aa, and to Archaeoglobus fulgidus phosphate ABC transporter, permease AF1357 TR:O28914 (EMBL:AE001010) (297 aa) fasta scores: E(): 5.2e-47, 47.959% id in 294 aa; ABC transporter permease complement(1457685..1458611) Staphylococcus aureus subsp. aureus MRSA252 2860187 YP_040804.1 CDS SAR1402 NC_002952.2 1458802 1459785 R Previously sequenced as Staphylococcus aureus thioredoxine reductase TR:Q9RL86 (EMBL:Y18637) (327 aa) fasta scores: E(): 4.6e-107, 99.694% id in 327 aa. Similar to Synechococcus sp phosphate assimilation protein SphX SW:SPHX_SYNP7 (P39665) (337 aa) fasta scores: E(): 2.6e-28, 37.363% id in 273 aa; phosphate-binding lipoprotein complement(1458802..1459785) Staphylococcus aureus subsp. aureus MRSA252 2860188 YP_040805.1 CDS SAR1403 NC_002952.2 1460096 1460998 R Similar to Bacillus subtilis hypothetical protein YitL TR:O06747 (EMBL:Z99109) (298 aa) fasta scores: E(): 5.8e-30, 37.354% id in 257 aa, and to Bacillus halodurans hypothetical protein BH1329 TR:Q9KD88 (EMBL:AP001511) (290 aa) fasta scores: E(): 2.6e-25, 33.579% id in 271 aa; hypothetical protein complement(1460096..1460998) Staphylococcus aureus subsp. aureus MRSA252 2860189 YP_040806.1 CDS SAR1404 NC_002952.2 1461145 1462746 D Similar to Bacillus subtilis hypothetical protein YkpA TR:O31716 (EMBL:Z99111) (540 aa) fasta scores: E(): 5.8e-131, 73.921% id in 533 aa, and to Streptococcus pyogenes ABC transporter ATP-binding protein SPY2210 TR:Q99XH2 (EMBL:AE006638) (539 aa) fasta scores: E(): 1e-115, 66.034% id in 527 aa; ABC transporter ATP-binding protein 1461145..1462746 Staphylococcus aureus subsp. aureus MRSA252 2860190 YP_040807.1 CDS lysC NC_002952.2 1463603 1464808 D catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 1463603..1464808 Staphylococcus aureus subsp. aureus MRSA252 2859813 YP_040808.1 CDS asd NC_002952.2 1464872 1465861 D Previously sequenced as Staphylococcus aureus aspartate semialdehyde dehydrogenase Asd TR:Q9EZ13 (EMBL:AF306669) (329 aa) fasta scores: E(): 1.3e-120, 98.784% id in 329 aa. Similar to Deinococcus radiodurans aspartate-semialdehyde dehydrogenase DR2008 TR:Q9RSW3 (EMBL:AE002038) (338 aa) fasta scores: E(): 1.5e-44, 43.844% id in 333 aa; aspartate semialdehyde dehydrogenase 1464872..1465861 Staphylococcus aureus subsp. aureus MRSA252 2859869 YP_040809.1 CDS dapA NC_002952.2 1465863 1466750 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 1465863..1466750 Staphylococcus aureus subsp. aureus MRSA252 2859262 YP_040810.1 CDS dapB NC_002952.2 1466747 1467469 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1466747..1467469 Staphylococcus aureus subsp. aureus MRSA252 2859263 YP_040811.1 CDS dapD NC_002952.2 1467496 1468215 D Similar to Escherichia coli 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase DapD or b0166 SW:DAPD_ECOLI (P03948) (274 aa) fasta scores: E(): 6.4e-11, 40.288% id in 139 aa. Previously sequenced as Staphylococcus aureus tetrahydrodipicolinate acetyltransferase DapD TR:Q9EZ10 (EMBL:AF306669) (239 aa) fasta scores: E(): 1.2e-81, 99.582% id in 239 aa; tetrahydrodipicolinate acetyltransferase 1467496..1468215 Staphylococcus aureus subsp. aureus MRSA252 2859264 YP_040812.1 CDS SAR1410 NC_002952.2 1468358 1469509 D Similar to Pyrococcus horikoshii hypothetical amidohydrolase PH1043 TR:O58754 (EMBL:AP000004) (387 aa) fasta scores: E(): 9.4e-39, 35.753% id in 372 aa. Previously sequenced as Staphylococcus aureus hippurate hydrolase HipO TR:Q9EZ09 (EMBL:AF306669) (383 aa) fasta scores: E(): 1.4e-158, 99.217% id in 383 aa; peptidase 1468358..1469509 Staphylococcus aureus subsp. aureus MRSA252 2860191 YP_040813.1 CDS dal NC_002952.2 1469514 1470599 D Similar to Staphylococcus aureus alanine racemase Alr SW:ALR_STAAU (Q9ZAH5) (382 aa) fasta scores: E(): 2.4e-18, 28.660% id in 321 aa. Previously sequenced as Staphylococcus aureus alanine racemase Dal TR:Q9EZ08 (EMBL:AF306669) (336 aa) fasta scores: E(): 8.7e-137, 99.405% id in 336 aa; alanine racemase 1469514..1470599 Staphylococcus aureus subsp. aureus MRSA252 2859261 YP_040814.1 CDS lysA NC_002952.2 1470589 1471854 D Similar to Bacillus subtilis diaminopimelate decarboxylase LysA SW:DCDA_BACSU (P23630) (441 aa) fasta scores: E(): 3e-75, 49.296% id in 426 aa. Previously sequenced as Staphylococcus aureus diaminopimelate decarboxylase LysA TR:Q9KWX7 (EMBL:Y18632) (283 aa) fasta scores: E(): 2.9e-100, 98.233% id in 283 aa; diaminopimelate decarboxylase 1470589..1471854 Staphylococcus aureus subsp. aureus MRSA252 2859812 YP_040815.1 CDS SAR1413 NC_002952.2 1472090 1472491 R Poor database matches. Similar to the N-terminal region of Escherichia coli O157:H7 EDL933 endonuclease YihG TR:AAG59051 (EMBL:AE005616) (310 aa) fasta scores: E(): 1.1, 25.954% id in 131 aa; hypothetical protein complement(1472090..1472491) Staphylococcus aureus subsp. aureus MRSA252 2860192 YP_040816.1 CDS cspA NC_002952.2 1472688 1472888 R Similar to Bacillus subtilis cold shock protein CspD SW:CSPD_BACSU (P51777) (66 aa) fasta scores: E(): 4.6e-20, 78.788% id in 66 aa. Previously sequenced as Staphylococcus aureus major cold shock protein CspA TR:Q9L534 (EMBL:AF259960) (66 aa) fasta scores: E(): 5.9e-26, 100.000% id in 66 aa. Similar to SAR0848, 80.303% identity (80.303% ungapped) in 66 aa overlap, and to SAR2790, 73.016% identity (73.016% ungapped) in 63 aa overlap; cold shock protein complement(1472688..1472888) Staphylococcus aureus subsp. aureus MRSA252 2859247 YP_040817.1 CDS SAR1415 NC_002952.2 1473059 1473367 R Poor database matches. Similar to Streptococcus pyogenes DNA binding protein SPY0100 TR:Q9A1U0 (EMBL:AE006481) (121 aa) fasta scores: E(): 2.7e-10, 31.915% id in 94 aa, and to Lactococcus lactis hypothetical protein YtbD TR:Q9CEJ2 (EMBL:AE006415) (122 aa) fasta scores: E(): 1.2e-05, 27.000% id in 100 aa; hypothetical protein complement(1473059..1473367) Staphylococcus aureus subsp. aureus MRSA252 2860193 YP_040818.1 CDS SAR1416 NC_002952.2 1473529 1473798 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1473529..1473798 Staphylococcus aureus subsp. aureus MRSA252 2860194 YP_040819.1 CDS SAR1417 NC_002952.2 1473823 1474446 D Poor database matches. Similar to Bacillus subtilis hypothetical protein XpaC SW:XPAC_BACSU (P37467) (204 aa) fasta scores: E(): 5.1e-11, 30.688% id in 189 aa; hypothetical protein 1473823..1474446 Staphylococcus aureus subsp. aureus MRSA252 2860195 YP_040820.1 CDS SAR1418 NC_002952.2 1474478 1475614 D Similar to Bacillus subtilis hypothetical protein YaaN SW:YAAN_BACSU (P37535) (386 aa) fasta scores: E(): 1.5e-51, 52.802% id in 339 aa, and to Lactococcus lactis hypothetical protein YnhC TR:Q9CFX8 (EMBL:AE006366) (392 aa) fasta scores: E(): 4.8e-47, 43.717% id in 382 aa; hypothetical protein 1474478..1475614 Staphylococcus aureus subsp. aureus MRSA252 2860196 YP_040821.1 CDS SAR1419 NC_002952.2 1475682 1477025 R Similar to Lactobacillus delbrueckii branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_LACDL (P54104) (446 aa) fasta scores: E(): 4.5e-44, 35.440% id in 443 aa, and to Staphylococcus aureus branched-chain amino acid carrier protein TR:O34007 (EMBL:U87144) (441 aa) fasta scores: E(): 8.8e-116, 82.517% id in 429 aa; branched-chain amino acid transporter protein complement(1475682..1477025) Staphylococcus aureus subsp. aureus MRSA252 2860197 YP_040822.1 CDS SAR1420 NC_002952.2 1477250 1479136 R Similar to Bacillus subtilis hypothetical protein YojO TR:O31849 (EMBL:Z99114) (661 aa) fasta scores: E(): 1.4e-49, 37.364% id in 645 aa. C-terminus is similar to the C-terminal region of Rhizobium loti hypothetical protein MLL3561 TR:BAB50427 (EMBL:AP003002) (632 aa) fasta scores: E(): 0.065, 21.028% id in 428 aa; hypothetical protein complement(1477250..1479136) Staphylococcus aureus subsp. aureus MRSA252 2860198 YP_040823.1 CDS SAR1421 NC_002952.2 1479150 1479941 R Similar to Pseudomonas stutzeri denitrification regulatory protein NirQ SW:NIRQ_PSEST (Q02441) (275 aa) fasta scores: E(): 4.2e-14, 30.417% id in 240 aa, and to Bacillus subtilis hypothetical protein YojN TR:O31850 (EMBL:Z99114) (304 aa) fasta scores: E(): 4.7e-51, 62.403% id in 258 aa; hypothetical protein complement(1479150..1479941) Staphylococcus aureus subsp. aureus MRSA252 2860199 YP_040824.1 CDS SAR1422 NC_002952.2 1480122 1480325 R Similar to Bacillus halodurans hypothetical protein BH2203 TR:Q9KAT3 (EMBL:AP001514) (67 aa) fasta scores: E(): 2.3e-12, 57.812% id in 64 aa, and to Bacillus subtilis hypothetical protein YozC TR:O31848 (EMBL:Z99114) (67 aa) fasta scores: E(): 4.6e-12, 52.239% id in 67 aa; hypothetical protein complement(1480122..1480325) Staphylococcus aureus subsp. aureus MRSA252 2860200 YP_040825.1 CDS SAR1423 NC_002952.2 1480354 1481163 R Similar to Rhizobium loti hypothetical protein MLL3759 TR:BAB50580 (EMBL:AP003002) (317 aa) fasta scores: E(): 7.7e-13, 26.087% id in 276 aa, and to Bacillus halodurans hypothetical protein BH2175 TR:Q9KAW1 (EMBL:AP001514) (327 aa) fasta scores: E(): 2.9e-12, 25.362% id in 276 aa; hypothetical protein complement(1480354..1481163) Staphylococcus aureus subsp. aureus MRSA252 2860201 YP_040826.1 CDS odhB NC_002952.2 1481753 1483024 R component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase complement(1481753..1483024) Staphylococcus aureus subsp. aureus MRSA252 2859175 YP_040827.1 CDS sucA NC_002952.2 1483038 1485836 R SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component complement(1483038..1485836) Staphylococcus aureus subsp. aureus MRSA252 2859174 YP_040828.1 CDS arlS NC_002952.2 1486310 1487665 R Two-component regulatory system family, sensor kinase. Previously sequenced as Staphylococcus aureus protein histidine kinase ArlS TR:Q9KJN3 (EMBL:AF165314) (451 aa) fasta scores: E(): 1.6e-154, 99.778% id in 451 aa. Similar to Listeria monocytogenes histidine kinase homologue LisK TR:Q9RPY9 (EMBL:AF139908) (483 aa) fasta scores: E(): 9.4e-43, 35.118% id in 467 aa; sensor kinase complement(1486310..1487665) Staphylococcus aureus subsp. aureus MRSA252 2859859 YP_040829.1 CDS arlR NC_002952.2 1487662 1488321 R Two-component regulatory system family, response regulator protein. Previously sequenced as Staphylococcus aureus response regulator ArlR TR:Q9KJN4 (EMBL:AF165314) (219 aa) fasta scores: E(): 8e-82, 100.000% id in 219 aa. Similar to Listeria monocytogenes LisR TR:Q9RPZ0 (EMBL:AF139908) (226 aa) fasta scores: E(): 2.9e-39, 53.744% id in 227 aa; response regulator protein complement(1487662..1488321) Staphylococcus aureus subsp. aureus MRSA252 2859858 YP_040830.1 CDS SAR1428 NC_002952.2 1488791 1488964 R No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein complement(1488791..1488964) Staphylococcus aureus subsp. aureus MRSA252 2860202 YP_040831.1 CDS SAR1429 NC_002952.2 1489107 1489721 R Similar to Bacillus megaterium hypothetical protein TR:Q06074 (EMBL:Z21972) (216 aa) fasta scores: E(): 3.9e-18, 38.220% id in 191 aa, and to Streptococcus pyogenes phosphatase TR:Q9AGC2 (EMBL:AF336821) (200 aa) fasta scores: E(): 2.3e-16, 36.313% id in 179 aa; hypothetical protein complement(1489107..1489721) Staphylococcus aureus subsp. aureus MRSA252 2860203 YP_040832.1 CDS murG NC_002952.2 1489738 1490808 R UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase complement(1489738..1490808) Staphylococcus aureus subsp. aureus MRSA252 2861324 YP_040833.1 CDS SAR1431 NC_002952.2 1490820 1491329 R Similar to Campylobacter jejuni acetyltransferase CJ1715 TR:Q9PLW3 (EMBL:AL139079) (176 aa) fasta scores: E(): 1.3e-11, 33.939% id in 165 aa, and to Lactococcus lactis hypothetical protein YwfD TR:Q9CDP2 (EMBL:AE006446) (169 aa) fasta scores: E(): 1.4e-09, 32.237% id in 152 aa; acetyltransferase complement(1490820..1491329) Staphylococcus aureus subsp. aureus MRSA252 2860502 YP_040834.1 CDS SAR1432 NC_002952.2 1491730 1493220 R Similar to Bartonella bacilliformis carboxy-terminal processing protease precursor CtpA SW:CTPA_BARBA (Q44879) (434 aa) fasta scores: E(): 4.2e-34, 32.767% id in 412 aa, and to Bacillus subtilis carboxy-terminal processing protease YzbD TR:O34666 (EMBL:AF006665) (466 aa) fasta scores: E(): 5.6e-57, 42.325% id in 456 aa. CDS contains an extended N-terminus in comparison to other orthologues; protease complement(1491730..1493220) Staphylococcus aureus subsp. aureus MRSA252 2860503 YP_040835.1 CDS SAR1433 NC_002952.2 1493459 1494406 D Identical to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 2.6e-127, 100.000% id in 315 aa, and similar to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 2.9e-71, 58.413% id in 315 aa; transposase 1493459..1494406 Staphylococcus aureus subsp. aureus MRSA252 2860504 YP_040836.1 CDS SAR1434 NC_002952.2 1494479 1494700 R Similar to Streptococcus pyogenes hypothetical protein SPY0467 TR:Q9A148 (EMBL:AE006506) (71 aa) fasta scores: E(): 2.5e-06, 38.462% id in 65 aa, and to Lactococcus lactis hypothetical protein YuiB TR:Q9CE43 (EMBL:AE006430) (69 aa) fasta scores: E(): 4e-06, 38.806% id in 67 aa; hypothetical protein complement(1494479..1494700) Staphylococcus aureus subsp. aureus MRSA252 2860505 YP_040837.1 CDS SAR1435 NC_002952.2 1494700 1495200 R Similar to Escherichia coli PTS system, glucose-specific IIA component Crr SW:PTGA_ECOLI (P08837) (168 aa) fasta scores: E(): 8.6e-22, 41.975% id in 162 aa, and to Bacillus halodurans PTS system, glucose-specific enzyme IIA component BH1515 TR:Q9KCQ4 (EMBL:AP001512) (173 aa) fasta scores: E(): 1.1e-29, 50.888% id in 169 aa. N-terminus is similar to the C-terminal regions of SAR0190, 58.333% identity (58.333% ungapped) in 120 aa overlap, and SAR2618, 50.407% identity (50.407% ungapped) in 123 aa overlap; PTS system glucose-specific transporter subunit IIA complement(1494700..1495200) Staphylococcus aureus subsp. aureus MRSA252 2860506 YP_040838.1 CDS SAR1436 NC_002952.2 1495212 1495640 R this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B complement(1495212..1495640) Staphylococcus aureus subsp. aureus MRSA252 2860507 YP_040839.1 CDS msrA2 NC_002952.2 1495633 1496166 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(1495633..1496166) Staphylococcus aureus subsp. aureus MRSA252 2861314 YP_040840.1 CDS SAR1438 NC_002952.2 1496252 1497091 R Similar to Lactococcus lactis hypothetical protein YejH TR:Q9CI68 (EMBL:AE006285) (285 aa) fasta scores: E(): 2.1e-25, 35.401% id in 274 aa, and to Bacillus subtilis hypothetical protein DegV SW:DEGV_BACSU (P32436) (281 aa) fasta scores: E(): 2.8e-24, 34.066% id in 273 aa; hypothetical protein complement(1496252..1497091) Staphylococcus aureus subsp. aureus MRSA252 2860508 YP_040841.1 CDS dfrB NC_002952.2 1497106 1497585 R Previously sequenced as Staphylococcus aureus trimethoprim-sensitive dihydrofolate reductase type I DfrB SW:DYRB_STAAU (P10167) (158 aa) fasta scores: E(): 3.1e-62, 100.000% id in 158 aa. Similar to Staphylococcus epidermidis dihydrofolate reductase DfrC SW:DYR_STAEP (Q59908) (161 aa) fasta scores: E(): 4.1e-52, 81.761% id in 159 aa; dihydrofolate reductase complement(1497106..1497585) Staphylococcus aureus subsp. aureus MRSA252 2859591 YP_040842.1 CDS thyA NC_002952.2 1497785 1498741 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(1497785..1498741) Staphylococcus aureus subsp. aureus MRSA252 2859533 YP_040843.1 CDS SAR1441 NC_002952.2 1499165 1499602 R Similar to Bacillus subtilis hypothetical protein YphP SW:YPHP_BACSU (P54170) (144 aa) fasta scores: E(): 3.6e-27, 57.343% id in 143 aa, and to Bacillus halodurans hypothetical protein BH1716 TR:Q9KC58 (EMBL:AP001512) (144 aa) fasta scores: E(): 1.2e-24, 54.545% id in 143 aa; hypothetical protein complement(1499165..1499602) Staphylococcus aureus subsp. aureus MRSA252 2860509 YP_040844.1 CDS SAR1442 NC_002952.2 1499618 1500742 R Similar to Bacillus subtilis hypothetical protein YpgR SW:YPGR_BACSU (P54169) (377 aa) fasta scores: E(): 4.4e-58, 45.067% id in 375 aa, and to Bacillus halodurans hypothetical protein BH1718 TR:Q9KC56 (EMBL:AP001512) (380 aa) fasta scores: E(): 7.8e-58, 43.968% id in 373 aa; hypothetical protein complement(1499618..1500742) Staphylococcus aureus subsp. aureus MRSA252 2860510 YP_040845.1 CDS SAR1443 NC_002952.2 1500780 1501031 R Similar to the N-terminal regions of Bacillus halodurans hypothetical protein BH1718 TR:Q9KC56 (EMBL:AP001512) (380 aa) fasta scores: E(): 6.3e-10, 42.169% id in 83 aa, and Bacillus subtilis hypothetical protein YpgR SW:YPGR_BACSU (P54169) (377 aa) fasta scores: E(): 3.5e-08, 38.554% id in 83 aa. Similar to N-terminal region SAR1442, 51.220% identity (51.220% ungapped) in 82 aa overlap. Possible gene remnant; hypothetical protein complement(1500780..1501031) Staphylococcus aureus subsp. aureus MRSA252 2860511 YP_040846.1 CDS SAR1444 NC_002952.2 1501043 1501237 R Similar to the C-terminal region of Escherichia coli dnaK suppressor protein DksA SW:DKSA_ECOLI (P18274) (151 aa) fasta scores: E(): 1.3, 28.333% id in 60 aa, and to the full length Bacillus subtilis hypothetical protein YpeQ SW:YPEQ_BACSU (P54165) (60 aa) fasta scores: E(): 5.8e-07, 46.939% id in 49 aa; hypothetical protein complement(1501043..1501237) Staphylococcus aureus subsp. aureus MRSA252 2860512 YP_040847.1 CDS SAR1445 NC_002952.2 1501482 1502186 D Similar to Bacillus subtilis hypothetical protein YpdP SW:YPDP_BACSU (P54163) (229 aa) fasta scores: E(): 3.3e-37, 46.575% id in 219 aa, and to Archaeoglobus fulgidus conserved hypothetical protein AF2110 TR:O28170 (EMBL:AE000958) (241 aa) fasta scores: E(): 3.4e-29, 38.559% id in 236 aa; hypothetical protein 1501482..1502186 Staphylococcus aureus subsp. aureus MRSA252 2860513 YP_040848.1 CDS SAR1446 NC_002952.2 1502427 1502828 D Similar to Enterococcus faecalis possible cell wall metabolism enzyme EbsB SW:EBSB_ENTFA (P36921) (135 aa) fasta scores: E(): 9.2e-17, 41.481% id in 135 aa, and to Bacillus halodurans hypothetical protein BH1770 TR:Q9KC04 (EMBL:AP001513) (135 aa) fasta scores: E(): 4.1e-11, 32.540% id in 126 aa; hypothetical protein 1502427..1502828 Staphylococcus aureus subsp. aureus MRSA252 2860514 YP_040849.1 CDS ebh NC_002952.2 1502887 1535127 R Very large protein. No significant database matches to the full length CDS. CDS contains 3 regions containing repeats, residues 2515 to 3120, 3120 to 9780, 9780 to 10480. Internal repeat region similar to Abiotrophia defectiva extracellular matrix binding protein Emb TR:O85472 (EMBL:AF067776) (2055 aa) fasta scores: E(): 1.1e-34, 23.420% id in 2105 aa. C-terminal region contains a hydrophobic domain, residues 10552 to 10573, followed by charged carboxyl-terminal tail; hypothetical protein complement(1502887..1535127) Staphylococcus aureus subsp. aureus MRSA252 2859609 YP_040850.1 CDS SAR1448 NC_002952.2 1535528 1536919 R Similar to Mycobacterium tuberculosis hypothetical protein MTCY98.02c TR:P71879 (EMBL:Z79702) (537 aa) fasta scores: E(): 2.6e-25, 28.883% id in 412 aa, and to Rhizobium loti transmembrane efflux protein MLL5686 TR:BAB52087 (EMBL:AP003007) (502 aa) fasta scores: E(): 1.6e-24, 27.470% id in 415 aa. Similar to SAR0109, 71.082% identity (71.082% ungapped) in 453 aa overlap, and to SAR2534, 57.204% identity (58.079% ungapped) in 465 aa overlap; transporter protein complement(1535528..1536919) Staphylococcus aureus subsp. aureus MRSA252 2860515 YP_040851.1 CDS SAR1449 NC_002952.2 1537076 1538398 R Similar to an internal region of Mus musculus large neutral amino acids transporter small subunit 2 LAT2 SW:LAT2_MOUSE (Q9QXW9) (531 aa) fasta scores: E(): 4.8e-33, 31.027% id in 448 aa, and to the full length Bacillus subtilis hypothetical protein YkbA TR:O34739 (EMBL:Z99110) (438 aa) fasta scores: E(): 3.6e-63, 42.955% id in 440 aa; amino acid permease complement(1537076..1538398) Staphylococcus aureus subsp. aureus MRSA252 2860516 YP_040852.1 CDS tdcB NC_002952.2 1538429 1539469 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(1538429..1539469) Staphylococcus aureus subsp. aureus MRSA252 2859522 YP_040853.1 CDS ald2 NC_002952.2 1539564 1540682 R Similar to Bacillus subtilis alanine dehydrogenase Ald SW:DHA_BACSU (Q08352) (378 aa) fasta scores: E(): 1.2e-56, 46.612% id in 369 aa, and to Enterobacter aerogenes alanine dehydrogenase AlaDH TR:Q9WX54 (EMBL:AB013821) (377 aa) fasta scores: E(): 2.2e-57, 47.568% id in 370 aa; alanine dehydrogenase complement(1539564..1540682) Staphylococcus aureus subsp. aureus MRSA252 2860989 YP_040854.1 CDS SAR1452 NC_002952.2 1541157 1542035 R Similar to Bacillus subtilis 5'-3' exonuclease YpcP SW:YPCP_BACSU (P54161) (296 aa) fasta scores: E(): 1.9e-54, 54.023% id in 261 aa. N-terminus is similar to the N-terminal region of Bacillus subtilis DNA polymerase I PolA SW:DPO1_BACSU (O34996) (880 aa) fasta scores: E(): 8.7e-32, 39.370% id in 254 aa; 5'-3' exonuclease complement(1541157..1542035) Staphylococcus aureus subsp. aureus MRSA252 2860517 YP_040855.1 CDS SAR1453 NC_002952.2 1542055 1545495 R Similar to Bacillus halodurans hypothetical protein BH1700 TR:Q9KC74 (EMBL:AP001512) (1205 aa) fasta scores: E(): 2.1e-28, 24.816% id in 1225 aa, and to Bacillus subtilis hypothetical protein YpbR SW:YPBR_BACSU (P54159) (1193 aa) fasta scores: E(): 1.3e-24, 25.333% id in 1125 aa; hypothetical protein complement(1542055..1545495) Staphylococcus aureus subsp. aureus MRSA252 2860518 YP_040856.1 CDS SAR1455 NC_002952.2 1547485 1547817 R hypothetical protein complement(1547485..1547817) Staphylococcus aureus subsp. aureus MRSA252 2860520 YP_040857.1 CDS SAR1456 NC_002952.2 1547901 1549046 R Similar to Bacillus subtilis hypothetical protein YpsC SW:YPSC_BACSU (P50840) (385 aa) fasta scores: E(): 3.7e-84, 56.806% id in 382 aa, and to Bacillus halodurans hypothetical protein BH1771 TR:Q9KC03 (EMBL:AP001513) (385 aa) fasta scores: E(): 1.3e-78, 56.000% id in 375 aa; hypothetical protein complement(1547901..1549046) Staphylococcus aureus subsp. aureus MRSA252 2860521 YP_040858.1 CDS SAR1457 NC_002952.2 1549697 1550041 R Similar to Streptococcus pyogenes hypothetical protein SPY1646 TR:Q99YL4 (EMBL:AE006595) (108 aa) fasta scores: E(): 1.4e-07, 41.818% id in 110 aa, and to Lactococcus lactis hypothetical protein YraB TR:Q9CF28 (EMBL:AE006396) (128 aa) fasta scores: E(): 2.9e-06, 43.089% id in 123 aa; hypothetical protein complement(1549697..1550041) Staphylococcus aureus subsp. aureus MRSA252 2860522 YP_040859.1 CDS SAR1458 NC_002952.2 1550055 1550618 R Similar to Bacillus subtilis hypothetical protein YpsA SW:YPSA_BACSU (P50838) (180 aa) fasta scores: E(): 5.2e-27, 42.938% id in 177 aa, and to Bacillus halodurans hypothetical protein BH1768 TR:Q9KC06 (EMBL:AP001513) (189 aa) fasta scores: E(): 2.8e-22, 36.022% id in 186 aa; hypothetical protein complement(1550055..1550618) Staphylococcus aureus subsp. aureus MRSA252 2860523 YP_040860.1 CDS SAR1459 NC_002952.2 1550611 1550961 R Similar to Bacillus halodurans hypothetical protein BH1707 TR:Q9KC67 (EMBL:AP001512) (131 aa) fasta scores: E(): 0.024, 28.723% id in 94 aa, and to Bacillus subtilis hypothetical protein YppE SW:YPPE_BACSU (P50833) (123 aa) fasta scores: E(): 0.097, 22.609% id in 115 aa; hypothetical protein complement(1550611..1550961) Staphylococcus aureus subsp. aureus MRSA252 2860524 YP_040861.1 CDS SAR1459a NC_002952.2 1551024 1551194 R No significant database matches. Doubtful CDS; hypothetical protein complement(1551024..1551194) Staphylococcus aureus subsp. aureus MRSA252 2860525 YP_040862.1 CDS recU NC_002952.2 1551500 1552126 D functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 1551500..1552126 Staphylococcus aureus subsp. aureus MRSA252 2859304 YP_040863.1 CDS pbp2 NC_002952.2 1552123 1554273 D Similar to Staphylococcus aureus penicillin-binding protein 2 Pbp2 TR:Q53729 (EMBL:X62288) (716 aa) fasta scores: E(): 0, 99.860% id in 716 aa, and to Bacillus halodurans penicillin-binding proteins 1A/1B BH1702 TR:Q9KC72 (EMBL:AP001512) (886 aa) fasta scores: E(): 2.5e-69, 35.970% id in 670 aa; penicillin-binding protein 2 1552123..1554273 Staphylococcus aureus subsp. aureus MRSA252 2861476 YP_040864.1 CDS SAR1462 NC_002952.2 1554823 1555164 R hypothetical protein complement(1554823..1555164) Staphylococcus aureus subsp. aureus MRSA252 2860526 YP_040865.1 CDS SAR1463 NC_002952.2 1555169 1555828 R Similar to Escherichia coli endonuclease III Nth SW:END3_ECOLI (P20625) (211 aa) fasta scores: E(): 8.1e-30, 46.667% id in 210 aa. Previously sequenced as Staphylococcus aureus endonuclease-like protein TR:Q9EUT1 (EMBL:AJ132191) (220 aa) fasta scores: E(): 2e-77, 92.273% id in 220 aa; endonuclease complement(1555169..1555828) Staphylococcus aureus subsp. aureus MRSA252 2860527 YP_040866.1 CDS SAR1464 NC_002952.2 1555818 1556504 R Similar to Bacillus subtilis DNA replication protein DnaD SW:DNAD_BACSU (P39787) (232 aa) fasta scores: E(): 1e-20, 36.792% id in 212 aa. Previously sequenced as Staphylococcus aureus DNA replication-like protein TR:Q9EUT0 (EMBL:AJ132191) (228 aa) fasta scores: E(): 6.9e-79, 99.123% id in 228 aa; hypothetical protein complement(1555818..1556504) Staphylococcus aureus subsp. aureus MRSA252 2860528 YP_040867.1 CDS asnC NC_002952.2 1556833 1558125 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1556833..1558125) Staphylococcus aureus subsp. aureus MRSA252 2859870 YP_040868.1 CDS SAR1466 NC_002952.2 1558447 1561140 R Similar to Bacillus subtilis probable ATP-dependent helicase DinG homologue DinG SW:DING_BACSU (P54394) (931 aa) fasta scores: E(): 3.3e-39, 29.642% id in 921 aa, and to Lactococcus lactis ATP-dependent helicase DinG TR:Q9CEK5 (EMBL:AE006413) (794 aa) fasta scores: E(): 1e-29, 26.705% id in 880 aa; hypothetical protein complement(1558447..1561140) Staphylococcus aureus subsp. aureus MRSA252 2860529 YP_040869.1 CDS birA NC_002952.2 1561164 1562135 R Similar to Bacillus subtilis BirA bifunctional protein [includes: biotin operon repressor; biotin--[acetyl-CoA-carboxylase] synthetase] BirA SW:BIRA_BACSU (P42975) (325 aa) fasta scores: E(): 1.1e-30, 33.435% id in 329 aa, and to Methanosarcina barkeri bifunctional biotin ligase/biotin operon repressor BirA TR:Q9HH16 (EMBL:AF317651) (326 aa) fasta scores: E(): 3.3e-30, 30.503% id in 318 aa; BirA bifunctional protein [includes: biotin operon repressor; biotin--[acetyl-CoA-carboxylase] synthetase complement(1561164..1562135) Staphylococcus aureus subsp. aureus MRSA252 2858972 YP_040870.1 CDS papS NC_002952.2 1562122 1563324 R catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase complement(1562122..1563324) Staphylococcus aureus subsp. aureus MRSA252 2861475 YP_040871.1 CDS SAR1469 NC_002952.2 1563329 1564471 R Similar to Bacillus subtilis glycosyl transferase YpjH SW:YPJH_BACSU (P42982) (377 aa) fasta scores: E(): 1.4e-74, 55.676% id in 370 aa, and to Bacillus halodurans hypothetical protein BH1683 TR:Q9KC90 (EMBL:AP001512) (375 aa) fasta scores: E(): 2.1e-74, 54.839% id in 372 aa; glycosyl transferase family protein complement(1563329..1564471) Staphylococcus aureus subsp. aureus MRSA252 2860530 YP_040872.1 CDS SAR1470 NC_002952.2 1564715 1565032 R Similar to Bacillus halodurans hypothetical protein JBH1679 TR:Q9KC94 (EMBL:AP001512) (114 aa) fasta scores: E(): 2.7e-23, 66.019% id in 103 aa, and to Bacillus subtilis hypothetical protein JojD SW:YPJD_BACSU (P42979) (111 aa) fasta scores: E(): 1.8e-22, 62.500% id in 104 aa; hypothetical protein complement(1564715..1565032) Staphylococcus aureus subsp. aureus MRSA252 2860531 YP_040873.1 CDS SAR1471 NC_002952.2 1565368 1566066 R Similar to Bacillus halodurans hypothetical protein BH1677 TR:Q9KC96 (EMBL:AP001512) (224 aa) fasta scores: E(): 3.3e-41, 55.455% id in 220 aa, and to Thermotoga maritima conserved hypothetical protein TM1511 TR:Q9X1J9 (EMBL:AE001799) (230 aa) fasta scores: E(): 4.9e-32, 46.606% id in 221 aa; hypothetical protein complement(1565368..1566066) Staphylococcus aureus subsp. aureus MRSA252 2860532 YP_040874.1 CDS SAR1472 NC_002952.2 1566120 1566707 R Similar to Bacillus subtilis hypothetical protein YpjA SW:YPJA_BACSU (P54392) (185 aa) fasta scores: E(): 1.2e-22, 41.071% id in 168 aa, and to Bacillus halodurans hypothetical protein BH1675 TR:Q9KC98 (EMBL:AP001512) (202 aa) fasta scores: E(): 4.6e-21, 43.017% id in 179 aa; hypothetical protein complement(1566120..1566707) Staphylococcus aureus subsp. aureus MRSA252 2860533 YP_040875.1 CDS SAR1473 NC_002952.2 1566697 1567272 R Similar to Bacillus halodurans hypothetical protein BH1670 TR:Q9KCA3 (EMBL:AP001512) (183 aa) fasta scores: E(): 0.00015, 23.256% id in 172 aa, and to Bacillus subtilis hypothetical protein YpiB SW:YPIB_BACSU (P54390) (179 aa) fasta scores: E(): 0.0015, 24.855% id in 173 aa; hypothetical protein complement(1566697..1567272) Staphylococcus aureus subsp. aureus MRSA252 2860534 YP_040876.1 CDS SAR1474 NC_002952.2 1567286 1568530 R Similar to Bacillus subtilis hypothetical protein YpiA SW:YPIA_BACSU (P54389) (423 aa) fasta scores: E(): 5.4e-36, 31.100% id in 418 aa, and to Lactococcus lactis hypothetical protein YljJ TR:Q9CGB4 (EMBL:AE006350) (418 aa) fasta scores: E(): 5e-27, 29.639% id in 415 aa; hypothetical protein complement(1567286..1568530) Staphylococcus aureus subsp. aureus MRSA252 2860535 YP_040877.1 CDS aroA NC_002952.2 1568537 1569835 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1568537..1569835) Staphylococcus aureus subsp. aureus MRSA252 2859860 YP_040878.1 CDS aroB NC_002952.2 1569845 1570909 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(1569845..1570909) Staphylococcus aureus subsp. aureus MRSA252 2859861 YP_040879.1 CDS aroC NC_002952.2 1570935 1572101 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(1570935..1572101) Staphylococcus aureus subsp. aureus MRSA252 2859862 YP_040880.1 CDS ndk NC_002952.2 1572570 1573019 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1572570..1573019) Staphylococcus aureus subsp. aureus MRSA252 2859164 YP_040881.1 CDS SAR1479 NC_002952.2 1573111 1574070 R Similar to Bacillus stearothermophilus heptaprenyl diphosphate synthase component II HepT SW:HEP2_BACST (P55785) (320 aa) fasta scores: E(): 4.4e-49, 44.728% id in 313 aa, and to Bacillus subtilis heptaprenyl diphosphate synthase component II HepT SW:HEP2_BACSU (P31114) (348 aa) fasta scores: E(): 8.3e-52, 46.474% id in 312 aa; heptaprenyl diphosphate synthase component II complement(1573111..1574070) Staphylococcus aureus subsp. aureus MRSA252 2860536 YP_040882.1 CDS ubiE NC_002952.2 1574072 1574797 R Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase complement(1574072..1574797) Staphylococcus aureus subsp. aureus MRSA252 2861161 YP_040883.1 CDS SAR1481 NC_002952.2 1574800 1575372 R Poor database matches. N-terminal region is similar to Micrococcus luteus component A of hexaprenyl diphosphate synthase HexS-A TR:O66127 (EMBL:AB003188) (143 aa) fasta scores: E(): 0.16, 27.407% id in 135 aa. Full length CDS is similar to internal region of Bacillus subtilis primosomal protein DnaI SW:DNAI_BACSU (P06567) (311 aa) fasta scores: E(): 0.28, 23.656% id in 186 aa; hypothetical protein complement(1574800..1575372) Staphylococcus aureus subsp. aureus MRSA252 2860537 YP_040884.1 CDS hup NC_002952.2 1575803 1576075 R Similar to Bacillus stearothermophilus DNA-binding protein HU Hup SW:DBH_BACST (P02346) (90 aa) fasta scores: E(): 3.2e-24, 80.000% id in 90 aa, and to Bacillus halodurans DNA-binding protein HU-1 BH1309 SW:DBH1_BACHD (Q9KDA5) (90 aa) fasta scores: E(): 2.4e-23, 77.528% id in 89 aa; DNA-binding protein HU complement(1575803..1576075) Staphylococcus aureus subsp. aureus MRSA252 2859649 YP_040885.1 CDS gpsA NC_002952.2 1576246 1577244 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(1576246..1577244) Staphylococcus aureus subsp. aureus MRSA252 2859939 YP_040886.1 CDS engA NC_002952.2 1577261 1578571 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(1577261..1578571) Staphylococcus aureus subsp. aureus MRSA252 2860538 YP_040887.1 CDS rpsA NC_002952.2 1578793 1579968 R in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 complement(1578793..1579968) Staphylococcus aureus subsp. aureus MRSA252 2860032 YP_040888.1 CDS cmk NC_002952.2 1580680 1581339 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(1580680..1581339) Staphylococcus aureus subsp. aureus MRSA252 2859238 YP_040889.1 CDS SAR1487 NC_002952.2 1581416 1582384 D Similar to Escherichia coli L-asparaginase II precursor AnsB SW:ASG2_ECOLI (P00805) (348 aa) fasta scores: E(): 1.4e-25, 30.120% id in 332 aa, and to Bacillus halodurans L-asparaginase BH1624 TR:Q9KCE7 (EMBL:AP001512) (322 aa) fasta scores: E(): 2.4e-61, 53.750% id in 320 aa. E. coli orthologue contains extra amino acids at the C-terminus in comparison to the CDS; L-asparaginase 1581416..1582384 Staphylococcus aureus subsp. aureus MRSA252 2860033 YP_040890.1 CDS SAR1488 NC_002952.2 1582499 1583485 R Similar to Bacillus halodurans hypothetical protein BH1623 TR:Q9KCE8 (EMBL:AP001512) (322 aa) fasta scores: E(): 6.2e-75, 61.199% id in 317 aa, and to Bacillus subtilis hypothetical protein YpdA SW:YPDA_BACSU (P50736) (324 aa) fasta scores: E(): 7.2e-75, 63.804% id in 326 aa; pyridine nucleotide-disulfide oxidoreductase complement(1582499..1583485) Staphylococcus aureus subsp. aureus MRSA252 2859464 YP_040891.1 CDS ebpS NC_002952.2 1583870 1585330 R Previously sequenced as Staphylococcus aureus cell surface elastin binding protein EbpS TR:Q53630 (EMBL:U48826) (486 aa) fasta scores: E(): 3.5e-143, 100.000% id in 486 aa. CDS contains a polar amino acid rich region, residues 403 to 433; cell surface elastin binding protein complement(1583870..1585330) Staphylococcus aureus subsp. aureus MRSA252 2859610 YP_040892.1 CDS SAR1490 NC_002952.2 1585483 1586862 R Similar to the N-terminal region of Escherichia coli ATP-dependent DNA helicase RecG SW:RECQ_ECOLI (P15043) (607 aa) fasta scores: E(): 9.6e-42, 34.186% id in 430 aa, and full length Bacillus subtilis ATP-dependent DNA helicase RecQ SW:RECQ_BACSU (P50729) (496 aa) fasta scores: E(): 3.1e-53, 37.528% id in 453 aa; DEAD/DEAH box helicase complement(1585483..1586862) Staphylococcus aureus subsp. aureus MRSA252 2859465 YP_040893.1 CDS SAR1491 NC_002952.2 1586852 1587805 R Similar to Bacillus subtilis hypothetical protein YpbB SW:YPBB_BACSU (P50728) (352 aa) fasta scores: E(): 3.6e-08, 22.154% id in 325 aa, and to Bacillus halodurans hypothetical protein BH1606 TR:Q9KCG5 (EMBL:AP001512) (359 aa) fasta scores: E(): 0.05, 21.813% id in 353 aa; hypothetical protein complement(1586852..1587805) Staphylococcus aureus subsp. aureus MRSA252 2859466 YP_040894.1 CDS SAR1492 NC_002952.2 1587913 1588161 D Similar to Bacillus thermoproteolyticus ferredoxin SW:FER_BACTH (P10245) (81 aa) fasta scores: E(): 2.7e-22, 76.250% id in 80 aa, and to Bacillus halodurans ferredoxin BH1605 TR:Q9KCG6 (EMBL:AP001512) (82 aa) fasta scores: E(): 2.3e-25, 84.146% id in 82 aa; ferredoxin 1587913..1588161 Staphylococcus aureus subsp. aureus MRSA252 2859467 YP_040895.1 CDS SAR1493 NC_002952.2 1588267 1588812 R Similar to Bacillus subtilis hypothetical protein YpaA SW:YPAA_BACSU (P50726) (190 aa) fasta scores: E(): 1.6e-24, 46.111% id in 180 aa, and to Thermotoga maritima conserved hypothetical protein TM1455 TR:Q9X1G6 (EMBL:AE001797) (183 aa) fasta scores: E(): 3.3e-12, 34.078% id in 179 aa; hypothetical protein complement(1588267..1588812) Staphylococcus aureus subsp. aureus MRSA252 2859468 YP_040896.1 CDS SAR1494 NC_002952.2 1589460 1590368 R No significant database matches. Similar to SAR1495, 73.630% identity (74.138% ungapped) in 292 aa overlap, and to SAR1566, 75.556% identity (76.923% ungapped) in 225 aa overlap; lipoprotein complement(1589460..1590368) Staphylococcus aureus subsp. aureus MRSA252 2859469 YP_040897.1 CDS SAR1495 NC_002952.2 1590426 1591331 R No significant database matches. Similar to SAR1494, 73.196% identity (73.196% ungapped) in 291 aa overlap, and to SAR1566, 74.222% identity (76.256% ungapped) in 225 aa overlap; lipoprotein complement(1590426..1591331) Staphylococcus aureus subsp. aureus MRSA252 2859470 YP_040898.1 CDS SAR1497 NC_002952.2 1592358 1593812 R Similar to Staphylococcus aureus temperate phage phiSLT amidase TR:Q9B0C3 (EMBL:AB045978) (484 aa) fasta scores: E(): 3.4e-188, 97.107% id in 484 aa, and to bacteriophage phi PVL amidase TR:O80064 (EMBL:AB009866) (484 aa) fasta scores: E(): 8.7e-186, 95.248% id in 484 aa. C-terminal region is similar to SAR2037, 93.878% identity (93.878% ungapped) in 98 aa overlap; amidase complement(1592358..1593812) Staphylococcus aureus subsp. aureus MRSA252 2859471 YP_040899.1 CDS SAR1498 NC_002952.2 1593824 1594126 R Highly similar to bacteriophage phi PVL holin TR:O80063 (EMBL:AB009866) (100 aa) fasta scores: E(): 1.7e-36, 99.000% id in 100 aa, and to Staphylococcus aureus temperate phage phiSLT holin TR:Q9B0C4 (EMBL:AB045978) (100 aa) fasta scores: E(): 4.3e-36, 97.000% id in 100 aa; holin complement(1593824..1594126) Staphylococcus aureus subsp. aureus MRSA252 2859472 YP_040900.1 CDS SAR1499 NC_002952.2 1594262 1594561 R Identical to bacteriophage phi ETA hypothetical protein Orf60 TR:Q9FZY5 (EMBL:AP001553) (99 aa) fasta scores: E(): 3.8e-31, 100.000% id in 99 aa, and similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf17 homologue TR:Q9MBN6 (EMBL:AB044554) (98 aa) fasta scores: E(): 5.2e-15, 50.515% id in 97 aa; hypothetical protein complement(1594262..1594561) Staphylococcus aureus subsp. aureus MRSA252 2859473 YP_040901.1 CDS SAR1500 NC_002952.2 1594607 1594771 R Similar to bacteriophage phi ETA hypothetical protein Orf59 TR:Q9FZY6 (EMBL:AP001553) (57 aa) fasta scores: E(): 2.9e-10, 65.306% id in 49 aa, and to bacteriophage phi-105 hypothetical protein Orf44 TR:Q9ZXD9 (EMBL:AB016282) (62 aa) fasta scores: E(): 1.4, 39.535% id in 43 aa; hypothetical protein complement(1594607..1594771) Staphylococcus aureus subsp. aureus MRSA252 2859474 YP_040902.1 CDS SAR1501 NC_002952.2 1594764 1595153 R Similar to bacteriophage phi ETA hypothetical protein Orf58 TR:Q9FZY7 (EMBL:AP001553) (125 aa) fasta scores: E(): 4.6e-11, 37.008% id in 127 aa; hypothetical protein complement(1594764..1595153) Staphylococcus aureus subsp. aureus MRSA252 2859475 YP_040903.1 CDS SAR1502 NC_002952.2 1595153 1596619 R Similar to bacteriophage phi ETA hypothetical protein Orf57 TR:Q9FZY8 (EMBL:AP001553) (607 aa) fasta scores: E(): 4.1e-14, 26.711% id in 599 aa; hypothetical protein complement(1595153..1596619) Staphylococcus aureus subsp. aureus MRSA252 2859476 YP_040904.1 CDS SAR1503 NC_002952.2 1596619 1598529 R Similar to bacteriophage phi ETA hypothetical protein Orf56 TR:Q9FZY9 (EMBL:AP001553) (632 aa) fasta scores: E(): 2.9e-105, 44.620% id in 632 aa; hypothetical protein complement(1596619..1598529) Staphylococcus aureus subsp. aureus MRSA252 2859477 YP_040905.1 CDS SAR1504 NC_002952.2 1598545 1598835 R Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf96 TR:Q9B0C8 (EMBL:AB045978) (96 aa) fasta scores: E(): 3e-35, 97.917% id in 96 aa; hypothetical protein complement(1598545..1598835) Staphylococcus aureus subsp. aureus MRSA252 2859478 YP_040906.1 CDS SAR1505 NC_002952.2 1598835 1600418 R Highly similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf527 TR:Q9B0C9 (EMBL:AB045978) (527 aa) fasta scores: E(): 2.1e-200, 99.810% id in 527 aa. N-terminus is similar to the N-terminal region of bacteriophage A118 hypothetical protein gp18 TR:Q9T1A5 (EMBL:AJ242593) (341 aa) fasta scores: E(): 9.5e-05, 28.814% id in 236 aa; hypothetical protein complement(1598835..1600418) Staphylococcus aureus subsp. aureus MRSA252 2859479 YP_040907.1 CDS SAR1506 NC_002952.2 1600427 1601251 R Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf191 TR:Q9B0D0 (EMBL:AB045978) (191 aa) fasta scores: E(): 7.7e-70, 95.767% id in 189 aa, and to bacteriophage A118 hypothetical protein gp17 TR:Q9T1A6 (EMBL:AJ242593) (272 aa) fasta scores: E(): 5.8e-18, 29.603% id in 277 aa; hypothetical protein complement(1600427..1601251) Staphylococcus aureus subsp. aureus MRSA252 2859480 YP_040908.1 CDS SAR1507 NC_002952.2 1601251 1607451 R N-terminal region is similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf1374 TR:Q9B0D2 (EMBL:AB045978) (1374 aa) fasta scores: E(): 0, 98.819% id in 1355 aa. C-terminal region is similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf588 TR:Q9B0D1 (EMBL:AB045978) (588 aa) fasta scores: E(): 5.6e-165, 96.758% id in 586 aa. Possible fusion protein. Contains coiled-coiled domain, residues 54 to 274; hypothetical protein complement(1601251..1607451) Staphylococcus aureus subsp. aureus MRSA252 2859481 YP_040909.1 CDS SAR1508 NC_002952.2 1607465 1607623 R No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein complement(1607465..1607623) Staphylococcus aureus subsp. aureus MRSA252 2859482 YP_040910.1 CDS SAR1509 NC_002952.2 1607665 1608015 R Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf116b TR:Q9B0D3 (EMBL:AB045978) (116 aa) fasta scores: E(): 9.4e-37, 100.000% id in 116 aa; hypothetical protein complement(1607665..1608015) Staphylococcus aureus subsp. aureus MRSA252 2859483 YP_040911.1 CDS SAR1510 NC_002952.2 1608073 1608528 R Similar to Staphylococcus aureus temperate phage phiSLT major tail protein TR:Q9B0D4 (EMBL:AB045978) (151 aa) fasta scores: E(): 5.9e-51, 96.026% id in 151 aa; major tail protein complement(1608073..1608528) Staphylococcus aureus subsp. aureus MRSA252 2859484 YP_040912.1 CDS SAR1511 NC_002952.2 1608620 1609261 R Highly similar to Staphylococcus aureus temperate phage phiSLT major tail protein TR:Q9B0D5 (EMBL:AB045978) (213 aa) fasta scores: E(): 8.6e-83, 99.531% id in 213 aa; major tail protein complement(1608620..1609261) Staphylococcus aureus subsp. aureus MRSA252 2859485 YP_040913.1 CDS SAR1512 NC_002952.2 1609296 1609691 R Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf131b TR:Q9B0D6 (EMBL:AB045978) (131 aa) fasta scores: E(): 3.3e-47, 100.000% id in 131 aa. Similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf 12 homologue TR:Q9MBP5 (EMBL:AB044554) (126 aa) fasta scores: E(): 0.56, 24.762% id in 105 aa; hypothetical protein complement(1609296..1609691) Staphylococcus aureus subsp. aureus MRSA252 2859486 YP_040914.1 CDS SAR1513 NC_002952.2 1609692 1610063 R Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf123 TR:Q9B0D7 (EMBL:AB045978) (123 aa) fasta scores: E(): 4.6e-42, 95.935% id in 123 aa; hypothetical protein complement(1609692..1610063) Staphylococcus aureus subsp. aureus MRSA252 2859487 YP_040915.1 CDS SAR1514 NC_002952.2 1610090 1610422 R Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf110 TR:Q9B0D8 (EMBL:AB045978) (110 aa) fasta scores: E(): 2e-41, 97.273% id in 110 aa, and to bacteriophage phi PVL hypothetical protein Orf 10 TR:O80049 (EMBL:AB009866) (111 aa) fasta scores: E(): 0.044, 30.189% id in 106 aa; hypothetical protein complement(1610090..1610422) Staphylococcus aureus subsp. aureus MRSA252 2859488 YP_040916.1 CDS SAR1515 NC_002952.2 1610434 1610712 R Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf92 TR:Q9B0D9 (EMBL:AB045978) (92 aa) fasta scores: E(): 4e-37, 100.000% id in 92 aa; hypothetical protein complement(1610434..1610712) Staphylococcus aureus subsp. aureus MRSA252 2859489 YP_040917.1 CDS SAR1516 NC_002952.2 1610781 1611944 R Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf387 TR:Q9B0E0 (EMBL:AB045978) (387 aa) fasta scores: E(): 4.6e-132, 100.000% id in 387 aa; hypothetical protein complement(1610781..1611944) Staphylococcus aureus subsp. aureus MRSA252 2859490 YP_040918.1 CDS SAR1517 NC_002952.2 1611956 1612729 R Highly similar to Staphylococcus aureus temperate phage phiSLT protease TR:Q9B0E1 (EMBL:AB045978) (257 aa) fasta scores: E(): 7.3e-88, 99.611% id in 257 aa. Similar to Lactococcus phage BK5-T ATP-dependent ClpP protein TR:AAK56806 (EMBL:AF176025) (237 aa) fasta scores: E(): 4.4e-10, 31.250% id in 224 aa; phage protease complement(1611956..1612729) Staphylococcus aureus subsp. aureus MRSA252 2859491 YP_040919.1 CDS SAR1518 NC_002952.2 1612713 1613951 R Similar to Staphylococcus aureus temperate phage phiSLT portal protein TR:Q9B0E2 (EMBL:AB045978) (412 aa) fasta scores: E(): 9.3e-154, 99.515% id in 412 aa. Similar to bacteriophage phi-105 hypothetical protein Orf25 TR:Q9ZXF8 (EMBL:AB016282) (416 aa) fasta scores: E(): 6.3e-19, 26.247% id in 381 aa; portal protein complement(1612713..1613951) Staphylococcus aureus subsp. aureus MRSA252 2859492 YP_040920.1 CDS SAR1519 NC_002952.2 1613956 1615656 R Similar to Staphylococcus aureus temperate phage phiSLT terminase large subunit TR:Q9B0E3 (EMBL:AB045978) (563 aa) fasta scores: E(): 0, 96.092% id in 563 aa, and to Staphylococcus aureus prophage phiPV83 phi PVL Orf 2 homologue TR:Q9MBQ2 (EMBL:AB044554) (564 aa) fasta scores: E(): 5.9e-28, 26.740% id in 546 aa; terminase large subunit complement(1613956..1615656) Staphylococcus aureus subsp. aureus MRSA252 2859493 YP_040921.1 CDS SAR1520 NC_002952.2 1615637 1615942 R Similar to Staphylococcus aureus temperate phage phiSLT terminase small subunit TR:Q9B0E4 (EMBL:AB045978) (101 aa) fasta scores: E(): 1.1e-35, 98.020% id in 101 aa; terminase small subunit complement(1615637..1615942) Staphylococcus aureus subsp. aureus MRSA252 2859494 YP_040922.1 CDS SAR1521 NC_002952.2 1616068 1616382 R Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf104b TR:Q9B0E5 (EMBL:AB045978) (104 aa) fasta scores: E(): 4.2e-34, 78.846% id in 104 aa, and to bacteriophage bIL285 hypothetical protein Orf39 TR:Q9AZZ0 (EMBL:AF323668) (150 aa) fasta scores: E(): 8.3e-08, 44.444% id in 72 aa; hypothetical protein complement(1616068..1616382) Staphylococcus aureus subsp. aureus MRSA252 2859495 YP_040923.1 CDS SAR1522 NC_002952.2 1616539 1616976 R Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf145 TR:Q9B0E6 (EMBL:AB045978) (145 aa) fasta scores: E(): 1.1e-48, 93.793% id in 145 aa, and to bacteriophage phi-11 transcriptional activator RinA SW:RINA_BPPHA (Q03182) (140 aa) fasta scores: E(): 1, 24.476% id in 143 aa; phage regulatory protein complement(1616539..1616976) Staphylococcus aureus subsp. aureus MRSA252 2859496 YP_040924.1 CDS SAR1523 NC_002952.2 1616989 1618347 R Similar to bacteriophage APSE-1 hypothetical protein P41 SW:VP41_BPAPS (Q9T1Q7) (460 aa) fasta scores: E(): 2.9e-54, 38.126% id in 459 aa. C-terminal region is similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf116a TR:Q9B0E7 (EMBL:AB045978) (116 aa) fasta scores: E(): 1.2e-32, 94.393% id in 107 aa; hypothetical protein complement(1616989..1618347) Staphylococcus aureus subsp. aureus MRSA252 2859497 YP_040925.1 CDS SAR1524 NC_002952.2 1618337 1618627 R Similar to bacteriophage APSE-1 hypothetical protein P44 SW:VP44_BPAPS (Q9T1Q4) (93 aa) fasta scores: E(): 1.5e-08, 42.857% id in 77 aa, and to Xylella fastidiosa phage-related protein XF2526 TR:Q9P9P9 (EMBL:AE004059) (92 aa) fasta scores: E(): 0.0013, 35.897% id in 78 aa; hypothetical protein complement(1618337..1618627) Staphylococcus aureus subsp. aureus MRSA252 2859498 YP_040926.1 CDS SAR1525 NC_002952.2 1618968 1621415 R No significant database matches to the full length CDS. Internal region is similar to Staphylococcus aureus mobile pathogenicity island hypothetical protein Orf11 TR:O54471 (EMBL:U93688) (257 aa) fasta scores: E(): 4.2e-37, 44.758% id in 248 aa. N-terminus is similar to the N-terminal region of bacteriophage APSE-1 hypothetical protein P3 TR:Q9T1U5 (EMBL:AF157835) (752 aa) fasta scores: E(): 1.7e-20, 25.852% id in 704 aa; hypothetical protein complement(1618968..1621415) Staphylococcus aureus subsp. aureus MRSA252 2859499 YP_040927.1 CDS SAR1526 NC_002952.2 1621468 1621668 R Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf66 TR:Q9B0E8 (EMBL:AB045978) (66 aa) fasta scores: E(): 1.3e-21, 98.485% id in 66 aa, and to bacteriophage phi PVL hypothetical protein Orf 60 TR:O80098 (EMBL:AB009866) (67 aa) fasta scores: E(): 6.6e-07, 44.615% id in 65 aa; exported phage protein complement(1621468..1621668) Staphylococcus aureus subsp. aureus MRSA252 2859500 YP_040929.1 CDS SAR1527 NC_002952.2 1621736 1621888 R Similar to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 57 homologue TR:Q9B0E9 (EMBL:AB045978) (51 aa) fasta scores: E(): 2.2e-20, 98.039% id in 51 aa, and to bacteriophage phi ETA hypothetical protein Orf37 TR:Q9G008 (EMBL:AP001553) (57 aa) fasta scores: E(): 2.6e-15, 80.357% id in 56 aa. Similar to SAR2069, 87.755% identity (89.583% ungapped) in 49 aa overlap; hypothetical protein complement(1621736..1621888) Staphylococcus aureus subsp. aureus MRSA252 2860605 YP_040930.1 CDS SAR1528 NC_002952.2 1621881 1622117 R Identical to Staphylococcus aureus prophage phiPV83 and temperate phage phiSLT hypothetical protein Orf 30 (Orf78) TR:Q9MBQ9 (EMBL:AB044554) (78 aa) fasta scores: E(): 1.3e-29, 100.000% id in 78 aa; hypothetical protein complement(1621881..1622117) Staphylococcus aureus subsp. aureus MRSA252 2860606 YP_040931.1 CDS SAR1529 NC_002952.2 1622142 1622378 R Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf77 TR:Q9B0F0 (EMBL:AB045978) (77 aa) fasta scores: E(): 1.3e-24, 88.158% id in 76 aa, and to bacteriophage phi PVL hypothetical protein Orf 55 TR:O80093 (EMBL:AB009866) (62 aa) fasta scores: E(): 4.6e-13, 85.106% id in 47 aa. Similar to SAR2071, 78.723% identity (78.723% ungapped) in 47 aa overlap; hypothetical protein complement(1622142..1622378) Staphylococcus aureus subsp. aureus MRSA252 2860607 YP_040932.1 CDS SAR1530 NC_002952.2 1622395 1622568 R hypothetical protein complement(1622395..1622568) Staphylococcus aureus subsp. aureus MRSA252 2860608 YP_040933.1 CDS SAR1531 NC_002952.2 1622605 1623141 R Similar to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 29 TR:Q9MBR0 (EMBL:AB044554) (178 aa) fasta scores: E(): 4.9e-65, 96.629% id in 178 aa, and to bacteriophage phi ETA hypothetical protein Orf34 TR:Q9G011 (EMBL:AP001553) (178 aa) fasta scores: E(): 5.4e-31, 55.191% id in 183 aa; hypothetical protein complement(1622605..1623141) Staphylococcus aureus subsp. aureus MRSA252 2860609 YP_040934.1 CDS SAR1532 NC_002952.2 1623134 1623382 R Similar to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 52 homologue TR:Q9B0F3 (EMBL:AB045978) (82 aa) fasta scores: E(): 5.8e-27, 96.341% id in 82 aa, and to bacteriophage phi PVL hypothetical protein Orf 52 TR:O80090 (EMBL:AB009866) (82 aa) fasta scores: E(): 1.4e-25, 93.902% id in 82 aa. Similar to SAR2074, 82.927% identity (82.927% ungapped) in 82 aa overlap; hypothetical protein complement(1623134..1623382) Staphylococcus aureus subsp. aureus MRSA252 2860610 YP_040935.1 CDS SAR1533 NC_002952.2 1623375 1623806 R Similar to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 27 TR:Q9MBR2 (EMBL:AB044554) (96 aa) fasta scores: E(): 0.013, 48.214% id in 56 aa, and to bacteriophage phi ETA hypothetical protein Orf31 TR:Q9G014 (EMBL:AP001553) (94 aa) fasta scores: E(): 0.028, 46.429% id in 56 aa. Contains coiled-coiled domain, residues 48 to 68; hypothetical protein complement(1623375..1623806) Staphylococcus aureus subsp. aureus MRSA252 2860611 YP_040936.1 CDS SAR1534 NC_002952.2 1623806 1623997 R hypothetical protein complement(1623806..1623997) Staphylococcus aureus subsp. aureus MRSA252 2860612 YP_040937.1 CDS SAR1535 NC_002952.2 1623994 1624386 R No significant database matches to the full length CDS. C-terminus is similar to the C-terminal region of bacteriophage phi ETA hypothetical protein Orf30 TR:Q9G015 (EMBL:AP001553) (50 aa) fasta scores: E(): 0.027, 82.609% id in 23 aa; hypothetical protein complement(1623994..1624386) Staphylococcus aureus subsp. aureus MRSA252 2860613 YP_040938.1 CDS SAR1536 NC_002952.2 1624401 1624643 R Similar to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 51 homologue TR:Q9B0F4 (EMBL:AB045978) (80 aa) fasta scores: E(): 7e-25, 83.750% id in 80 aa, and to Staphylococcus aureus prophage phiPV83 phi PVL Orf 51 homologue TR:Q9MBR3 (EMBL:AB044554) (82 aa) fasta scores: E(): 2.6e-24, 84.810% id in 79 aa. Similar to SAR2076, 82.500% identity (82.500% ungapped) in 80 aa overlap; hypothetical protein complement(1624401..1624643) Staphylococcus aureus subsp. aureus MRSA252 2860614 YP_040939.1 CDS SAR1537 NC_002952.2 1624658 1624858 R Similar to bacteriophage phi ETA hypothetical protein Orf28 TR:Q9G017 (EMBL:AP001553) (56 aa) fasta scores: E(): 1.5e-19, 96.429% id in 56 aa. CDS is extended at the N-terminus in comparison to the bacteriophage phi ETA orthologue. Possible alternative translational start site; hypothetical protein complement(1624658..1624858) Staphylococcus aureus subsp. aureus MRSA252 2860615 YP_040940.1 CDS SAR1538 NC_002952.2 1624861 1625118 R Similar to the C-terminal regions of bacteriophage T7 1.7 protein SW:V17_BPT7 (P03781) (196 aa) fasta scores: E(): 0.73, 37.143% id in 70 aa, and bacteriophage phiYeO3-12 1.7 protein TR:Q9T137 (EMBL:AJ251805) (156 aa) fasta scores: E(): 1.3, 29.412% id in 85 aa; hypothetical protein complement(1624861..1625118) Staphylococcus aureus subsp. aureus MRSA252 2860616 YP_040941.1 CDS SAR1539 NC_002952.2 1625118 1625519 R Similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf 50 TR:Q9MBR4 (EMBL:AB044554) (123 aa) fasta scores: E(): 1.7e-07, 36.029% id in 136 aa; DNA-binding protein complement(1625118..1625519) Staphylococcus aureus subsp. aureus MRSA252 2860617 YP_040942.1 CDS SAR1540 NC_002952.2 1625519 1625704 R Similar to bacteriophage phi ETA hypothetical protein Orf26 TR:Q9G019 (EMBL:AP001553) (61 aa) fasta scores: E(): 4.4e-13, 60.656% id in 61 aa, and to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 23 TR:Q9MBR6 (EMBL:AB044554) (61 aa) fasta scores: E(): 2.5e-09, 55.738% id in 61 aa; hypothetical protein complement(1625519..1625704) Staphylococcus aureus subsp. aureus MRSA252 2860618 YP_040943.1 CDS SAR1541 NC_002952.2 1625717 1627678 R Similar to bacteriophage SP02 DNA polymerase L SW:DPOL_BPSP2 (P06225) (648 aa) fasta scores: E(): 6.5e-134, 54.103% id in 658 aa, and to the N-terminal region of bacteriophage APSE-1 probable DNA polymerase 45 SW:DPOL_BPAPS (Q9T1Q3) (993 aa) fasta scores: E(): 1e-34, 29.363% id in 722 aa; DNA polymerase complement(1625717..1627678) Staphylococcus aureus subsp. aureus MRSA252 2860619 YP_040944.1 CDS SAR1542 NC_002952.2 1627737 1628294 R Similar to bacteriophage APSE-1 hypothetical protein P50 SW:VP50_BPAPS (Q9T1P8) (184 aa) fasta scores: E(): 3.2e-10, 30.055% id in 183 aa. CDS is extended at the N-terminus in comparison to the bacteriophage APSE-1 protein. Possible alternative translational start site; hypothetical protein complement(1627737..1628294) Staphylococcus aureus subsp. aureus MRSA252 2860620 YP_040945.1 CDS SAR1543 NC_002952.2 1628320 1629486 R Similar to bacteriophage APSE-1 hypothetical protein P51 SW:VP51_BPAPS (Q9T1P7) (439 aa) fasta scores: E(): 1.2e-16, 31.925% id in 426 aa, and to Xylella fastidiosa phage-related protein XF2522 TR:Q9PAJ4 (EMBL:AE004059) (425 aa) fasta scores: E(): 1.8e-06, 29.594% id in 419 aa; hypothetical protein complement(1628320..1629486) Staphylococcus aureus subsp. aureus MRSA252 2860621 YP_040946.1 CDS SAR1544 NC_002952.2 1629483 1629845 R hypothetical protein complement(1629483..1629845) Staphylococcus aureus subsp. aureus MRSA252 2860622 YP_040947.1 CDS SAR1545 NC_002952.2 1629860 1630183 R hypothetical protein complement(1629860..1630183) Staphylococcus aureus subsp. aureus MRSA252 2860623 YP_040948.1 CDS SAR1546 NC_002952.2 1630262 1630423 R Similar to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 38 homologue TR:Q9B0G7 (EMBL:AB045978) (53 aa) fasta scores: E(): 3.3e-20, 96.226% id in 53 aa, and to bacteriophage phi PVL hypothetical protein Orf 38 TR:O80077 (EMBL:AB009866) (53 aa) fasta scores: E(): 6.9e-20, 96.226% id in 53 aa. Similar to SAR2091, 92.453% identity (92.453% ungapped) in 53 aa overlap; hypothetical protein complement(1630262..1630423) Staphylococcus aureus subsp. aureus MRSA252 2860624 YP_040949.1 CDS SAR1547 NC_002952.2 1630436 1630699 R Similar to bacteriophage phi PVL hypothetical protein Orf 37 TR:O80076 (EMBL:AB009866) (87 aa) fasta scores: E(): 2.9e-34, 96.552% id in 87 aa, and to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 37 homologue TR:Q9B0G8 (EMBL:AB045978) (87 aa) fasta scores: E(): 7.7e-33, 93.103% id in 87 aa; DNA-binding protein complement(1630436..1630699) Staphylococcus aureus subsp. aureus MRSA252 2860625 YP_040950.1 CDS SAR1548 NC_002952.2 1630726 1630941 R Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf71 TR:Q9B0G9 (EMBL:AB045978) (71 aa) fasta scores: E(): 1.3e-25, 100.000% id in 71 aa; hypothetical protein complement(1630726..1630941) Staphylococcus aureus subsp. aureus MRSA252 2860626 YP_040951.1 CDS SAR1549 NC_002952.2 1630996 1631361 D Identical to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf121 TR:Q9B0H0 (EMBL:AB045978) (121 aa) fasta scores: E(): 2.1e-43, 100.000% id in 121 aa; hypothetical protein 1630996..1631361 Staphylococcus aureus subsp. aureus MRSA252 2861153 YP_040952.1 CDS SAR1550 NC_002952.2 1631330 1631575 R hypothetical protein complement(1631330..1631575) Staphylococcus aureus subsp. aureus MRSA252 2859103 YP_040953.1 CDS SAR1551 NC_002952.2 1631642 1632022 D Similar to bacteriophage phi PVL hypothetical protein Orf 36 TR:Q9T1Z5 (EMBL:AB009866) (126 aa) fasta scores: E(): 7.1e-35, 69.841% id in 126 aa; hypothetical protein 1631642..1632022 Staphylococcus aureus subsp. aureus MRSA252 2859104 YP_040954.1 CDS SAR1552 NC_002952.2 1632009 1632206 R Similar to bacteriophage phi PVL hypothetical protein Orf 35 TR:O80075 (EMBL:AB009866) (65 aa) fasta scores: E(): 7.6e-17, 67.692% id in 65 aa. Similar to SAR2095, 67.692% identity (67.692% ungapped) in 65 aa overlap; hypothetical protein complement(1632009..1632206) Staphylococcus aureus subsp. aureus MRSA252 2859105 YP_040955.1 CDS SAR1553 NC_002952.2 1632529 1632678 R hypothetical protein complement(1632529..1632678) Staphylococcus aureus subsp. aureus MRSA252 2859106 YP_040956.1 CDS SAR1554 NC_002952.2 1632693 1633136 R Similar to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 7 TR:Q9MBT2 (EMBL:AB044554) (147 aa) fasta scores: E(): 2.6e-50, 97.959% id in 147 aa; hypothetical protein complement(1632693..1633136) Staphylococcus aureus subsp. aureus MRSA252 2859107 YP_040957.1 CDS SAR1555 NC_002952.2 1633154 1633378 R Similar to Lactococcus bacteriophage phi31 Cro repressor TR:Q9G0E7 (EMBL:AJ292531) (74 aa) fasta scores: E(): 1.3e-12, 58.333% id in 72 aa, and to bacteriophage TP901-1, and bacteriophage bIL285, modulator of repressor protein Mor TR:O48504 (EMBL:Y14232) (72 aa) fasta scores: E(): 1.4e-13, 55.556% id in 72 aa; regulatory protein complement(1633154..1633378) Staphylococcus aureus subsp. aureus MRSA252 2859108 YP_040958.1 CDS SAR1556 NC_002952.2 1633540 1633920 D N-terminus is similar to the N-terminal regions of bacteriophage phi PVL repressor TR:O80070 (EMBL:AB009866) (256 aa) fasta scores: E(): 1.8e-14, 47.368% id in 114 aa, and to bacteriophage bIL285 repressor Orf4 TR:Q9B013 (EMBL:AF323668) (180 aa) fasta scores: E(): 4.5e-11, 51.724% id in 87 aa; regulatory protein 1633540..1633920 Staphylococcus aureus subsp. aureus MRSA252 2859109 YP_040959.1 CDS SAR1557 NC_002952.2 1633942 1634400 D Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf153 TR:Q9B0H5 (EMBL:AB045978) (153 aa) fasta scores: E(): 1.4e-41, 75.817% id in 153 aa, and to bacteriophage A118 gp35 TR:Q9T189 (EMBL:AJ242593) (163 aa) fasta scores: E(): 6e-08, 31.008% id in 129 aa; hypothetical protein 1633942..1634400 Staphylococcus aureus subsp. aureus MRSA252 2859110 YP_040960.1 CDS SAR1558 NC_002952.2 1634418 1634852 D Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf144 TR:Q9B0H6 (EMBL:AB045978) (144 aa) fasta scores: E(): 1.2e-42, 98.611% id in 144 aa; lipoprotein 1634418..1634852 Staphylococcus aureus subsp. aureus MRSA252 2859111 YP_040961.1 CDS SAR1559 NC_002952.2 1634881 1635276 D Highly similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf131a TR:Q9B0H7 (EMBL:AB045978) (131 aa) fasta scores: E(): 7.6e-51, 99.237% id in 131 aa, and to the C-terminal region of Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 3 TR:Q9MBT6 (EMBL:AB044554) (149 aa) fasta scores: E(): 7.7e-48, 94.656% id in 131 aa; hypothetical protein 1634881..1635276 Staphylococcus aureus subsp. aureus MRSA252 2859112 YP_040962.1 CDS SAR1560 NC_002952.2 1635366 1635488 D hypothetical protein 1635366..1635488 Staphylococcus aureus subsp. aureus MRSA252 2859113 YP_040963.1 CDS SAR1561 NC_002952.2 1635475 1636098 R Similar to bacteriophage phi PVL hypothetical protein Orf 30 TR:O80069 (EMBL:AB009866) (204 aa) fasta scores: E(): 3.1e-05, 28.986% id in 207 aa, and to Staphylococcus aureus temperate phage phiSLT phi PVL orf 30 homologue TR:Q9B0H8 (EMBL:AB045978) (204 aa) fasta scores: E(): 2.7e-05, 28.986% id in 207 aa; hypothetical protein complement(1635475..1636098) Staphylococcus aureus subsp. aureus MRSA252 2859114 YP_040964.1 CDS SAR1562 NC_002952.2 1636208 1637413 D Similar to bacteriophage phi PVL and temperate phage phiSLT integrase TR:O80068 (EMBL:AB009866) (401 aa) fasta scores: E(): 7.8e-138, 99.751% id in 401 aa, and to the C-terminal region of bacteriophage L54a excisionase Xis SW:VINT_BPL54 (P20709) (354 aa) fasta scores: E(): 9.5e-89, 73.580% id in 352 aa; phage integrase 1636208..1637413 Staphylococcus aureus subsp. aureus MRSA252 2859115 YP_040965.1 CDS srrB NC_002952.2 1640667 1642433 R Two-component regulatory system family, sensor kinase. Previously sequenced as Staphylococcus aureus staphylococcal respiratory response protein (histidine kinase) SrrB TR:Q9L523 (EMBL:AF260326) (583 aa) fasta scores: E(): 2.7e-205, 99.828% id in 583 aa. Similar to Bacillus subtilis sensor protein ResE SW:RESE_BACSU (P35164) (589 aa) fasta scores: E(): 1.4e-59, 33.893% id in 596 aa. Possible alternative translational start site; sensor kinase complement(1640667..1642433) Staphylococcus aureus subsp. aureus MRSA252 2859501 YP_040966.1 CDS srrA NC_002952.2 1642399 1643142 R Two-component regulatory system family, response regulator protein. Previously sequenced as Staphylococcus aureus staphylococcal respiratory response protein SrrA TR:Q9L524 (EMBL:AF260326) (241 aa) fasta scores: E(): 3.1e-92, 100.000% id in 241 aa. Similar to Bacillus halodurans two-component response regulator BH1580 TR:Q9KCJ1 (EMBL:AP001512) (238 aa) fasta scores: E(): 1.7e-64, 73.043% id in 230 aa; response regulator protein complement(1642399..1643142) Staphylococcus aureus subsp. aureus MRSA252 2859161 YP_040967.1 CDS rluB NC_002952.2 1643257 1643994 R Similar to Bacillus subtilis ribosomal large subunit pseudouridine synthase B RluB SW:RLUB_BACSU (P35159) (229 aa) fasta scores: E(): 1.6e-47, 60.444% id in 225 aa, and to Bacillus halodurans pseudouridylate synthase BH1576 TR:Q9KCJ5 (EMBL:AP001512) (242 aa) fasta scores: E(): 2e-48, 60.084% id in 238 aa; ribosomal large subunit pseudouridine synthase B complement(1643257..1643994) Staphylococcus aureus subsp. aureus MRSA252 2859275 YP_040968.1 CDS SAR1570 NC_002952.2 1643987 1644529 R Similar to Bacillus subtilis hypothetical protein YpuH SW:YPUH_BACSU (P35155) (197 aa) fasta scores: E(): 4.4e-16, 38.503% id in 187 aa, and to Bacillus halodurans hypothetical protein BH1561 TR:Q9KCL0 (EMBL:AP001512) (197 aa) fasta scores: E(): 1.5e-12, 34.078% id in 179 aa; hypothetical protein complement(1643987..1644529) Staphylococcus aureus subsp. aureus MRSA252 2859118 YP_040969.1 CDS SAR1571 NC_002952.2 1644522 1645277 R Similar to Bacillus subtilis hypothetical protein YpuG SW:YPUG_BACSU (P35154) (251 aa) fasta scores: E(): 1.4e-32, 43.145% id in 248 aa, and to Bacillus halodurans hypothetical protein BH1560 TR:Q9KCL1 (EMBL:AP001512) (260 aa) fasta scores: E(): 1.6e-28, 42.683% id in 246 aa. Possible alternative translation start site; hypothetical protein complement(1644522..1645277) Staphylococcus aureus subsp. aureus MRSA252 2860823 YP_040970.1 CDS SAR1572 NC_002952.2 1645345 1645851 D Similar to Bacillus subtilis hypothetical protein YpuF SW:YPUF_BACSU (P17617) (174 aa) fasta scores: E(): 1e-12, 31.977% id in 172 aa, and to Bacillus halodurans hypothetical protein BH1559 TR:Q9KCL2 (EMBL:AP001512) (178 aa) fasta scores: E(): 7.7e-09, 27.647% id in 170 aa; hypothetical protein 1645345..1645851 Staphylococcus aureus subsp. aureus MRSA252 2860824 YP_040971.1 CDS xerD NC_002952.2 1645929 1646816 R Similar to Escherichia coli integrase/recombinase XerD SW:XERD_ECOLI (P21891) (298 aa) fasta scores: E(): 4.3e-44, 44.178% id in 292 aa. Previously sequenced as Staphylococcus aureus site-specific recombinase XerD TR:Q9KJF7 (EMBL:AF173869) (295 aa) fasta scores: E(): 1.6e-109, 98.299% id in 294 aa; integrase/recombinase complement(1645929..1646816) Staphylococcus aureus subsp. aureus MRSA252 2860431 YP_040972.1 CDS fur NC_002952.2 1646865 1647314 R Previously sequenced as Staphylococcus aureus iron uptake regulatory protein Fur TR:Q9R303 (EMBL:AF118839) (149 aa) fasta scores: E(): 2.1e-56, 99.329% id in 149 aa. Similar to Bacillus subtilis ferric uptake regulation protein fur SW:FUR_BACSU (P54574) (149 aa) fasta scores: E(): 2.2e-41, 75.342% id in 146 aa; iron uptake regulatory protein complement(1646865..1647314) Staphylococcus aureus subsp. aureus MRSA252 2860686 YP_040973.1 CDS SAR1575 NC_002952.2 1647419 1647961 R Similar to Bacillus subtilis ADP-ribose pyrophosphatase NudF SW:ADPP_BACSU (P54570) (185 aa) fasta scores: E(): 5.4e-26, 48.851% id in 174 aa, and to Bacillus halodurans BH1524 TR:Q9KCP5 (EMBL:AP001512) (183 aa) fasta scores: E(): 3.1e-28, 52.907% id in 172 aa; ADP-ribose pyrophosphatase complement(1647419..1647961) Staphylococcus aureus subsp. aureus MRSA252 2860825 YP_040974.1 CDS SAR1576 NC_002952.2 1648043 1648951 D Similar to Bacillus subtilis hypothetical oxidoreductase YqkF SW:YQKF_BACSU (P54569) (306 aa) fasta scores: E(): 1.3e-45, 48.852% id in 305 aa, and to Bacillus halodurans oxidoreductase BH1011 TR:Q9KE47 (EMBL:AP001510) (297 aa) fasta scores: E(): 1.5e-44, 49.342% id in 304 aa; aldo/keto reductase 1648043..1648951 Staphylococcus aureus subsp. aureus MRSA252 2860826 YP_040975.1 CDS SAR1577 NC_002952.2 1649167 1649415 R hypothetical protein complement(1649167..1649415) Staphylococcus aureus subsp. aureus MRSA252 2860827 YP_040976.1 CDS SAR1578 NC_002952.2 1649431 1650189 R Similar to Bacillus subtilis hypothetical oxidoreductase YqjQ SW:YQJQ_BACSU (P54554) (259 aa) fasta scores: E(): 2.1e-17, 29.839% id in 248 aa, and to Bacillus halodurans oxidoreductase BH1506 TR:Q9KCR3 (EMBL:AP001512) (259 aa) fasta scores: E(): 7.1e-16, 30.000% id in 260 aa; short chain dehydrogenase complement(1649431..1650189) Staphylococcus aureus subsp. aureus MRSA252 2860828 YP_040977.1 CDS SAR1579 NC_002952.2 1650328 1651143 D Similar to Bacillus subtilis pyrroline-5-carboxylate reductase 2 proI SW:PROI_BACSU (P54552) (278 aa) fasta scores: E(): 4.2e-23, 35.294% id in 255 aa, and to Bacillus subtilis pyrroline-5-carboxylate reductase 1 ProH SW:PROH_BACSU (P14383) (270 aa) fasta scores: E(): 3.1e-20, 32.636% id in 239 aa; pyrroline-5-carboxylate reductase 1650328..1651143 Staphylococcus aureus subsp. aureus MRSA252 2860829 YP_040978.1 CDS SAR1581 NC_002952.2 1651248 1652168 R Similar to Bacillus subtilis hypothetical protein YqjK SW:YQJK_BACSU (P54548) (307 aa) fasta scores: E(): 6.8e-47, 43.046% id in 302 aa, and to Bacillus halodurans hypothetical protein BH1713 TR:Q9KC61 (EMBL:AP001512) (309 aa) fasta scores: E(): 4.4e-45, 42.532% id in 308 aa; hypothetical protein complement(1651248..1652168) Staphylococcus aureus subsp. aureus MRSA252 2860830 YP_040979.1 CDS zwf NC_002952.2 1652481 1653965 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1652481..1653965 Staphylococcus aureus subsp. aureus MRSA252 2859634 YP_040980.1 CDS SAR1583 NC_002952.2 1654195 1655061 D Similar to Bacillus subtilis probable transcriptional regulator (AraC/XylS family) YdeE TR:P96662 (EMBL:AB001488) (290 aa) fasta scores: E(): 4.7e-16, 26.117% id in 291 aa, and to Lactococcus lactis hypothetical protein TR:O32788 (EMBL:X92946) (281 aa) fasta scores: E(): 1.4e-13, 27.211% id in 294 aa; AraC family transcription regulator 1654195..1655061 Staphylococcus aureus subsp. aureus MRSA252 2860831 YP_040981.1 CDS malA NC_002952.2 1655144 1656793 R Similar to Staphylococcus xylosus alpha-D-1,4-glucosidase MalA TR:Q60015 (EMBL:X78853) (549 aa) fasta scores: E(): 1.2e-181, 79.342% id in 547 aa, and to Bacillus halodurans exo-alpha-1,4-glucosidase BH3868 TR:Q9K664 (EMBL:AP001520) (553 aa) fasta scores: E(): 2.5e-141, 62.774% id in 548 aa; alpha-D-1,4-glucosidase complement(1655144..1656793) Staphylococcus aureus subsp. aureus MRSA252 2861155 YP_040982.1 CDS malR NC_002952.2 1656809 1657828 R Similar to Staphylococcus xylosus maltose operon transcriptional repressor MalR SW:MALR_STAXY (Q56201) (337 aa) fasta scores: E(): 1.5e-46, 44.083% id in 338 aa, and to Streptococcus pyogenes maltose operon transcriptional repressor SPY1293 TR:Q99ZC1 (EMBL:AE006568) (339 aa) fasta scores: E(): 1.3e-30, 32.059% id in 340 aa; maltose operon transcriptional repressor complement(1656809..1657828) Staphylococcus aureus subsp. aureus MRSA252 2861156 YP_040983.1 CDS SAR1586 NC_002952.2 1658022 1658393 R Similar to Lactococcus lactis hypothetical protein YfhJ TR:Q9CHY4 (EMBL:AE006292) (122 aa) fasta scores: E(): 4.8e-09, 38.596% id in 114 aa, and to Bacillus subtilis hypothetical protein YetH TR:O31535 (EMBL:Z99107) (120 aa) fasta scores: E(): 0.00015, 30.400% id in 125 aa; glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein complement(1658022..1658393) Staphylococcus aureus subsp. aureus MRSA252 2860832 YP_040984.1 CDS SAR1587 NC_002952.2 1658869 1659768 R Similar to Exiguobacterium acetylicum guanosine kinase Gsk TR:O24767 (EMBL:AB005149) (303 aa) fasta scores: E(): 2.5e-09, 22.449% id in 294 aa, and to Escherichia coli hypothetical sugar kinase YeiC SW:YEIC_ECOLI (P30235) (313 aa) fasta scores: E(): 5.7e-19, 29.352% id in 293 aa; PfkB family carbohydrate kinase complement(1658869..1659768) Staphylococcus aureus subsp. aureus MRSA252 2860833 YP_040985.1 CDS gnd NC_002952.2 1661312 1662718 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(1661312..1662718) Staphylococcus aureus subsp. aureus MRSA252 2859935 YP_040986.1 CDS SAR1590 NC_002952.2 1662786 1663919 R Similar to Salmonella typhimurium peptidase T PepT SW:PEPT_SALTY (P26311) (409 aa) fasta scores: E(): 3.9e-14, 24.757% id in 412 aa, and to Bacillus halodurans hypothetical protein BH1469 TR:Q9KCV0 (EMBL:AP001512) (372 aa) fasta scores: E(): 4.8e-72, 56.604% id in 371 aa; peptidase complement(1662786..1663919) Staphylococcus aureus subsp. aureus MRSA252 2860835 YP_040987.1 CDS SAR1591 NC_002952.2 1664488 1665468 R Similar to Bacillus subtilis hypothetical protein YqjA SW:YQJA_BACSU (P54538) (322 aa) fasta scores: E(): 1.3e-39, 39.683% id in 315 aa, and to Bacillus halodurans hypothetical protein BH1464 TR:Q9KCV5 (EMBL:AP001512) (326 aa) fasta scores: E(): 6.3e-34, 36.156% id in 307 aa; hypothetical protein complement(1664488..1665468) Staphylococcus aureus subsp. aureus MRSA252 2860836 YP_040988.1 CDS SAR1592 NC_002952.2 1665482 1665919 R Similar to Bacillus subtilis hypothetical protein YqiW SW:YQIW_BACSU (P54534) (145 aa) fasta scores: E(): 4.7e-38, 68.056% id in 144 aa, and to Bacillus halodurans hypothetical protein BH2759 TR:Q9K991 (EMBL:AP001516) (145 aa) fasta scores: E(): 3.8e-35, 65.714% id in 140 aa; hypothetical protein complement(1665482..1665919) Staphylococcus aureus subsp. aureus MRSA252 2860837 YP_040989.1 CDS bfmB NC_002952.2 1666269 1667543 R Similar to Bacillus subtilis lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex BfmB SW:ODB2_BACSU (P37942) (424 aa) fasta scores: E(): 4.5e-80, 55.220% id in 431 aa, and to Bacillus halodurans branched-chain alpha-keto acid dehydrogenase E2 BH2761 TR:Q9K989 (EMBL:AP001516) (426 aa) fasta scores: E(): 3.4e-80, 55.172% id in 435 aa; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex complement(1666269..1667543) Staphylococcus aureus subsp. aureus MRSA252 2859886 YP_040990.1 CDS bfmBAB NC_002952.2 1667556 1668539 R Similar to Bacillus subtilis 2-oxoisovalerate dehydrogenase beta subunit BfmBAB SW:ODBB_BACSU (P37941) (327 aa) fasta scores: E(): 4e-89, 66.972% id in 327 aa, and to Bacillus halodurans branched-chain alpha-keto acid dehydrogenase E1 BH2762 TR:Q9K988 (EMBL:AP001516) (327 aa) fasta scores: E(): 7.8e-91, 67.278% id in 327 aa; 2-oxoisovalerate dehydrogenase subunit beta complement(1667556..1668539) Staphylococcus aureus subsp. aureus MRSA252 2858967 YP_040991.1 CDS bfmBAA NC_002952.2 1668539 1669531 R Similar to Bacillus subtilis 2-oxoisovalerate dehydrogenase alpha subunit BfmBAA SW:ODBA_BACSU (P37940) (330 aa) fasta scores: E(): 1.4e-60, 53.251% id in 323 aa, and to Bacillus halodurans branched-chain alpha-keto acid dehydrogenase E1 BH2763 TR:Q9K987 (EMBL:AP001516) (330 aa) fasta scores: E(): 1.8e-63, 56.000% id in 325 aa; 2-oxoisovalerate dehydrogenase subunit alpha complement(1668539..1669531) Staphylococcus aureus subsp. aureus MRSA252 2858966 YP_040992.1 CDS bfmBC NC_002952.2 1669547 1670968 R Similar to Bacillus subtilis dihydrolipoamide dehydrogenase BfmBC SW:DLD2_BACSU (P54533) (474 aa) fasta scores: E(): 3.4e-80, 48.842% id in 475 aa, and to Bacillus halodurans dihydrolipoamide dehydrogenase BH2764 TR:Q9K986 (EMBL:AP001516) (474 aa) fasta scores: E(): 4.5e-80, 48.745% id in 478 aa; dihydrolipoamide dehydrogenase complement(1669547..1670968) Staphylococcus aureus subsp. aureus MRSA252 2858968 YP_040993.1 CDS SAR1597 NC_002952.2 1671119 1672798 R Similar to Escherichia coli DNA repair protein RecN SW:RECN_ECOLI (P05824) (553 aa) fasta scores: E(): 2.7e-41, 33.989% id in 559 aa, and to Bacillus halodurans DNA repair protein BH2776 SW:RECN_BACHD (Q9K974) (565 aa) fasta scores: E(): 3.3e-62, 41.547% id in 556 aa; DNA repair protein complement(1671119..1672798) Staphylococcus aureus subsp. aureus MRSA252 2860838 YP_040994.1 CDS argR NC_002952.2 1672814 1673266 R regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor complement(1672814..1673266) Staphylococcus aureus subsp. aureus MRSA252 2859856 YP_040995.1 CDS SAR1599 NC_002952.2 1673697 1674578 R Similar to Bacillus stearothermophilus geranyltranstransferase SW:ISPA_BACST (Q08291) (297 aa) fasta scores: E(): 1e-46, 47.492% id in 299 aa, and to Bacillus halodurans geranyltranstransferase BH2781 TR:Q9K969 (EMBL:AP001516) (294 aa) fasta scores: E(): 3.2e-46, 47.222% id in 288 aa; geranyltranstransferase complement(1673697..1674578) Staphylococcus aureus subsp. aureus MRSA252 2860839 YP_040996.1 CDS SAR1600 NC_002952.2 1674556 1674786 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1674556..1674786) Staphylococcus aureus subsp. aureus MRSA252 2860840 YP_040997.1 CDS xseA NC_002952.2 1674779 1676116 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1674779..1676116) Staphylococcus aureus subsp. aureus MRSA252 2860841 YP_040998.1 CDS nusB NC_002952.2 1676133 1676522 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(1676133..1676522) Staphylococcus aureus subsp. aureus MRSA252 2860842 YP_040999.1 CDS SAR1603 NC_002952.2 1676582 1676944 R Similar to Bacillus subtilis hypothetical protein YqhY SW:YQHY_BACSU (P54519) (135 aa) fasta scores: E(): 6.7e-13, 42.342% id in 111 aa, and to Bacillus halodurans hypothetical protein BH2786 TR:Q9K964 (EMBL:AP001516) (132 aa) fasta scores: E(): 2.9e-11, 40.000% id in 110 aa; hypothetical protein complement(1676582..1676944) Staphylococcus aureus subsp. aureus MRSA252 2860843 YP_041000.1 CDS accC NC_002952.2 1676959 1678314 R an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit complement(1676959..1678314) Staphylococcus aureus subsp. aureus MRSA252 2859054 YP_041001.1 CDS accB NC_002952.2 1678314 1678778 R Similar to Bacillus subtilis biotin carboxyl carrier protein of acetyl-CoA carboxylase AccB SW:BCCP_BACSU (P49786) (159 aa) fasta scores: E(): 6.7e-20, 50.318% id in 157 aa, and to Synechocystis sp biotin carboxyl carrier protein of acetyl-CoA carboxylase SLR0435 TR:Q55120 (EMBL:D64001) (154 aa) fasta scores: E(): 4.5e-18, 41.935% id in 155 aa; biotin carboxyl carrier protein of acetyl-CoA carboxylase complement(1678314..1678778) Staphylococcus aureus subsp. aureus MRSA252 2859053 YP_041002.1 CDS efp NC_002952.2 1679252 1679809 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(1679252..1679809) Staphylococcus aureus subsp. aureus MRSA252 2859611 YP_041003.1 CDS SAR1607 NC_002952.2 1679835 1680896 R Similar to Bacillus halodurans Xaa-Pro dipeptidase BH2800 TR:Q9K950 (EMBL:AP001516) (355 aa) fasta scores: E(): 2.8e-62, 48.148% id in 351 aa, and to Bacillus subtilis peptidase YqhT SW:YQHT_BACSU (P54518) (353 aa) fasta scores: E(): 3.4e-59, 46.307% id in 352 aa; peptidase complement(1679835..1680896) Staphylococcus aureus subsp. aureus MRSA252 2860844 YP_041004.1 CDS SAR1608 NC_002952.2 1681001 1681582 D No significant database matches. Contains coiled-coiled domain, residues 38 to 59; hypothetical protein 1681001..1681582 Staphylococcus aureus subsp. aureus MRSA252 2860845 YP_041005.1 CDS SAR1609 NC_002952.2 1681596 1681814 D Poor database matches. Similar to the N-terminal region of Bacillus halodurans hypothetical protein BH2804 TR:Q9K946 (EMBL:AP001516) (136 aa) fasta scores: E(): 9.2, 29.032% id in 62 aa, and to the C-terminal region of Anabaena sp strain pcc 7120 hypothetical protein TR:Q44229 (EMBL:U13768) (108 aa) fasta scores: E(): 2.7, 30.000% id in 50 aa; hypothetical protein 1681596..1681814 Staphylococcus aureus subsp. aureus MRSA252 2860846 YP_041006.1 CDS SAR1610 NC_002952.2 1681878 1682708 R Similar to Bacillus halodurans lipoate protein ligase BH2812 TR:Q9K938 (EMBL:AP001516) (276 aa) fasta scores: E(): 1.9e-70, 64.364% id in 275 aa, and to Bacillus subtilis hypothetical protein YqhM TR:O32018 (EMBL:Z99116) (278 aa) fasta scores: E(): 5.4e-68, 62.182% id in 275 aa; lipoate-protein ligase A protein complement(1681878..1682708) Staphylococcus aureus subsp. aureus MRSA252 2860847 YP_041007.1 CDS SAR1611 NC_002952.2 1682866 1683252 D Similar to Bacillus subtilis hypothetical protein YqhL SW:YQHL_BACSU (P54510) (126 aa) fasta scores: E(): 6.1e-21, 51.200% id in 125 aa, and to Bacillus halodurans hypothetical protein BH2813 TR:Q9K937 (EMBL:AP001516) (125 aa) fasta scores: E(): 1.7e-19, 48.387% id in 124 aa; hypothetical protein 1682866..1683252 Staphylococcus aureus subsp. aureus MRSA252 2860848 YP_041008.1 CDS SAR1612 NC_002952.2 1683637 1685109 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; glycine dehydrogenase subunit 2 complement(1683637..1685109) Staphylococcus aureus subsp. aureus MRSA252 2860849 YP_041009.1 CDS SAR1613 NC_002952.2 1685102 1686457 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein; glycine dehydrogenase subunit 1 complement(1685102..1686457) Staphylococcus aureus subsp. aureus MRSA252 2860850 YP_041010.1 CDS gcvT NC_002952.2 1686468 1687559 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(1686468..1687559) Staphylococcus aureus subsp. aureus MRSA252 2860696 YP_041011.1 CDS SAR1615 NC_002952.2 1687718 1688242 R Similar to Bacillus subtilis shikimate kinase AroK SW:AROK_BACSU (P37944) (186 aa) fasta scores: E(): 2.9e-09, 32.164% id in 171 aa, and to Aquifex aeolicus shikimate kinase AQ_2177 SW:AROK_AQUAE (O67925) (168 aa) fasta scores: E(): 2.2e-12, 34.507% id in 142 aa; shikimate kinase complement(1687718..1688242) Staphylococcus aureus subsp. aureus MRSA252 2860851 YP_041012.1 CDS SAR1616 NC_002952.2 1688475 1688972 R Poor database matches. Similar to Streptococcus pyogenes competence protein SPY0106 TR:Q9A1T4 (EMBL:AE006481) (144 aa) fasta scores: E(): 0.054, 27.068% id in 133 aa. Possible alternative translational start site; hypothetical protein complement(1688475..1688972) Staphylococcus aureus subsp. aureus MRSA252 2860852 YP_041013.1 CDS SAR1617 NC_002952.2 1688890 1689189 R Poor database matches. Similar to Streptococcus gordonii challis hypothetical protein ComYC TR:O06668 (EMBL:U81957) (105 aa) fasta scores: E(): 7.9, 18.367% id in 98 aa; hypothetical protein complement(1688890..1689189) Staphylococcus aureus subsp. aureus MRSA252 2860853 YP_041014.1 CDS SAR1618 NC_002952.2 1689176 1689610 R Similar to Bacillus subtilis comG operon protein 4 precursor ComG4 SW:CMGD_BACSU (P25956) (143 aa) fasta scores: E(): 0.92, 21.233% id in 146 aa, and to Burkholderia cepacia type II secretion pathway protein GspH TR:Q9LAN3 (EMBL:AF127982) (157 aa) fasta scores: E(): 3.6, 26.174% id in 149 aa; hypothetical protein complement(1689176..1689610) Staphylococcus aureus subsp. aureus MRSA252 2860854 YP_041015.1 CDS SAR1619 NC_002952.2 1689600 1689911 R Similar to Bacillus subtilis comG operon protein 3 precursor ComG3 SW:CMGC_BACSU (P25955) (98 aa) fasta scores: E(): 1.5e-10, 41.758% id in 91 aa, and to Bacillus halodurans comG operon protein 3 homologue precursor BH2827 SW:CMGC_BACHD (Q9K923) (102 aa) fasta scores: E(): 7e-10, 35.714% id in 98 aa; hypothetical protein complement(1689600..1689911) Staphylococcus aureus subsp. aureus MRSA252 2860855 YP_041016.1 CDS SAR1620 NC_002952.2 1689925 1690995 R Similar to Bacillus subtilis comG operon protein 2 ComG2 SW:CMGB_BACSU (P25954) (323 aa) fasta scores: E(): 6.2e-21, 24.138% id in 319 aa, and to Pseudomonas putida type 4 fimbrial assembly protein PilC SW:PILC_PSEPU (P36641) (401 aa) fasta scores: E(): 1.7e-11, 23.907% id in 343 aa; hypothetical protein complement(1689925..1690995) Staphylococcus aureus subsp. aureus MRSA252 2860856 YP_041017.1 CDS SAR1621 NC_002952.2 1690967 1691941 R Poor database matches. N-terminus is similar to the N-terminal region of Bacillus subtilis comG operon protein 1 ComG1 SW:CMGA_BACSU (P25953) (356 aa) fasta scores: E(): 4.6e-32, 39.405% id in 269 aa; hypothetical protein complement(1690967..1691941) Staphylococcus aureus subsp. aureus MRSA252 2860857 YP_041018.1 CDS SAR1622 NC_002952.2 1691993 1692616 R Similar to Bacillus halodurans hypothetical protein BH2820 TR:Q9K930 (EMBL:AP001516) (211 aa) fasta scores: E(): 3.6e-28, 49.038% id in 208 aa, and to Bacillus subtilis hypothetical protein YqgX SW:YQGX_BACSU (P54501) (211 aa) fasta scores: E(): 4.9e-26, 41.232% id in 211 aa; metallo-beta-lactamase superfamily protein complement(1691993..1692616) Staphylococcus aureus subsp. aureus MRSA252 2860858 YP_041019.1 CDS SAR1623 NC_002952.2 1692613 1692942 R Similar to Staphylococcus xylosus hypothetical protein DglA SW:DGLA_STAXY (Q56200) (107 aa) fasta scores: E(): 1.8e-30, 80.189% id in 106 aa, and to the C-terminal region of Bacillus halodurans hypothetical protein BH1437 TR:Q9KCY2 (EMBL:AP001512) (358 aa) fasta scores: E(): 4.8e-19, 57.407% id in 108 aa; hypothetical protein complement(1692613..1692942) Staphylococcus aureus subsp. aureus MRSA252 2860859 YP_041020.1 CDS glkA NC_002952.2 1692942 1693928 R Similar to Staphylococcus xylosus glucokinase GlkA SW:GLK_STAXY (Q56198) (328 aa) fasta scores: E(): 1.3e-109, 83.537% id in 328 aa, and to Bacillus megaterium glucose kinase Glk TR:O31392 (EMBL:AJ000005) (324 aa) fasta scores: E(): 1.6e-46, 42.947% id in 319 aa; glucokinase complement(1692942..1693928) Staphylococcus aureus subsp. aureus MRSA252 2859919 YP_041021.1 CDS SAR1625 NC_002952.2 1693925 1694128 R Similar to Bacillus subtilis hypothetical protein YqgQ SW:YQGQ_BACSU (P54494) (71 aa) fasta scores: E(): 9.1e-05, 33.333% id in 63 aa, and to Streptococcus pyogenes hypothetical protein SPY1530 TR:Q99YU8 (EMBL:AE006586) (67 aa) fasta scores: E(): 0.0011, 41.270% id in 63 aa. Doubtful CDS, poor translational start site; hypothetical protein complement(1693925..1694128) Staphylococcus aureus subsp. aureus MRSA252 2860860 YP_041022.1 CDS SAR1626 NC_002952.2 1694109 1695572 R Similar to Bacillus halodurans hypothetical protein BH1421 TR:Q9KCZ8 (EMBL:AP001512) (514 aa) fasta scores: E(): 4.9e-19, 24.376% id in 521 aa, and to Bacillus subtilis hypothetical protein YqgP SW:YQGP_BACSU (P54493) (507 aa) fasta scores: E(): 5e-15, 23.450% id in 516 aa; hypothetical protein complement(1694109..1695572) Staphylococcus aureus subsp. aureus MRSA252 2860861 YP_041023.1 CDS SAR1627 NC_002952.2 1695584 1696123 R Similar to Homo sapiens 5-formyltetrahydrofolate cyclo-ligase MthFS SW:FTHC_HUMAN (P49914) (202 aa) fasta scores: E(): 1.8e-08, 27.083% id in 192 aa, and to Streptococcus mutans hypothetical protein TR:O66124 (EMBL:AB001562) (178 aa) fasta scores: E(): 3.7e-20, 39.080% id in 174 aa; 5-formyltetrahydrofolate cyclo-ligase complement(1695584..1696123) Staphylococcus aureus subsp. aureus MRSA252 2861092 YP_041024.1 CDS rpmG NC_002952.2 1696332 1696481 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(1696332..1696481) Staphylococcus aureus subsp. aureus MRSA252 2860162 YP_041025.1 CDS pbpF NC_002952.2 1696594 1698669 R Previously sequenced as Staphylococcus aureus penicillin-binding protein PbpF TR:Q9XDB3 (EMBL:AF098801) (691 aa) fasta scores: E(): 0, 99.421% id in 691 aa. Similar to Streptococcus pneumoniae penicillin-binding protein 2b Pbp2B TR:Q9R8Q9 (EMBL:AF068901) (680 aa) fasta scores: E(): 1.9e-65, 33.333% id in 672 aa; penicillin-binding protein 3 complement(1696594..1698669) Staphylococcus aureus subsp. aureus MRSA252 2861479 YP_041026.1 CDS sodA NC_002952.2 1698789 1699388 R Similar to Staphylococcus aureus superoxide dismutase SodA TR:Q9Z5W5 (EMBL:AF121672) (199 aa) fasta scores: E(): 5.8e-82, 100.000% id in 199 aa, and to Staphylococcus xylosus superoxide dismutase Sod TR:Q9K4V3 (EMBL:AJ276960) (199 aa) fasta scores: E(): 6.6e-76, 91.457% id in 199 aa. Similar to SAR0135, 74.874% identity (74.874% ungapped) in 199 aa overlap; superoxide dismutase complement(1698789..1699388) Staphylococcus aureus subsp. aureus MRSA252 2859150 YP_041027.1 CDS zur NC_002952.2 1699664 1700074 R Similar to Bacillus subtilis zinc-specific metalloregulatory protein Zur SW:ZUR_BACSU (P54479) (145 aa) fasta scores: E(): 1.6e-26, 51.852% id in 135 aa. Previously sequenced as Staphylococcus aureus ferric uptake regulation protein homologue Zur TR:Q9R3G5 (EMBL:AF121672) (136 aa) fasta scores: E(): 6.4e-52, 100.000% id in 136 aa; zinc-specific metalloregulatory protein complement(1699664..1700074) Staphylococcus aureus subsp. aureus MRSA252 2859633 YP_041028.1 CDS mreB NC_002952.2 1700061 1700924 R Previously sequenced as Staphylococcus aureus ABC transporter MreB TR:Q9LAP5 (EMBL:AF121672) (277 aa) fasta scores: E(): 2e-87, 100.000% id in 277 aa. Similar to Staphylococcus xylosus ABC transporter ZurM TR:Q9K4V5 (EMBL:AJ276960) (286 aa) fasta scores: E(): 7.2e-77, 82.807% id in 285 aa; ABC transporter permease complement(1700061..1700924) Staphylococcus aureus subsp. aureus MRSA252 2861311 YP_041029.1 CDS mreA NC_002952.2 1700966 1701751 R Similar to Staphylococcus aureus ABC transporter MreA TR:Q9RGL9 (EMBL:AF121672) (261 aa) fasta scores: E(): 7.3e-85, 99.617% id in 261 aa, and to Staphylococcus xylosus ABC transporter ZurA TR:Q9K4V6 (EMBL:AJ276960) (257 aa) fasta scores: E(): 4.4e-67, 78.740% id in 254 aa. Possible alternative translational start sites; ABC transporter ATP-binding protein complement(1700966..1701751) Staphylococcus aureus subsp. aureus MRSA252 2861310 YP_041030.1 CDS SAR1634 NC_002952.2 1701877 1702767 R Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV complement(1701877..1702767) Staphylococcus aureus subsp. aureus MRSA252 2861093 YP_041031.1 CDS SAR1635 NC_002952.2 1702777 1704123 R Similar to N-terminal region of Escherichia coli cold-shock deaD-box protein A DeaD SW:DEAD_ECOLI (P23304) (628 aa) fasta scores: E(): 2.3e-38, 29.806% id in 463 aa, and to the full length Bacillus subtilis probable RNA helicase YqfR SW:YQFR_BACSU (P54475) (438 aa) fasta scores: E(): 3e-72, 47.153% id in 439 aa; helicase complement(1702777..1704123) Staphylococcus aureus subsp. aureus MRSA252 2861094 YP_041032.1 CDS SAR1636 NC_002952.2 1704237 1705337 R Similar to Bacillus halodurans hypothetical protein BH1380 SW:YD80_BACHD (Q9KD39) (372 aa) fasta scores: E(): 7.9e-48, 37.903% id in 372 aa, and to Bacillus subtilis hypothetical protein YqfO SW:YQFO_BACSU (P54472) (373 aa) fasta scores: E(): 5.6e-43, 36.438% id in 365 aa; hypothetical protein complement(1704237..1705337) Staphylococcus aureus subsp. aureus MRSA252 2861095 YP_041033.1 CDS SAR1637 NC_002952.2 1705340 1706017 R Similar to Lactococcus lactis hypothetical protein YkiC TR:Q9CGM4 (EMBL:AE006340) (230 aa) fasta scores: E(): 7e-29, 45.815% id in 227 aa, and to Streptococcus pyogenes hypothetical protein SPY0930 TR:Q9A050 (EMBL:AE006542) (228 aa) fasta scores: E(): 1.1e-26, 42.788% id in 208 aa; hypothetical protein complement(1705340..1706017) Staphylococcus aureus subsp. aureus MRSA252 2861096 YP_041034.1 CDS rpoD NC_002952.2 1706148 1707254 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD complement(1706148..1707254) Staphylococcus aureus subsp. aureus MRSA252 2860171 YP_041035.1 CDS dnaG NC_002952.2 1707478 1709277 R Similar to Bacillus subtilis DNA primase DnaG SW:PRIM_BACSU (P05096) (603 aa) fasta scores: E(): 7.4e-70, 36.529% id in 605 aa. Previously sequenced as Staphylococcus aureus DNA primase DnaG SW:PRIM_STAAU (O05338) (572 aa) fasta scores: E(): 4.3e-208, 97.898% id in 571 aa; DNA primase complement(1707478..1709277) Staphylococcus aureus subsp. aureus MRSA252 2859601 YP_041036.1 CDS SAR1640 NC_002952.2 1709338 1710156 R Similar to Bacillus subtilis hypothetical protein YqfL SW:YQFL_BACSU (P54470) (270 aa) fasta scores: E(): 1.3e-52, 58.015% id in 262 aa, and to Bacillus halodurans hypothetical protein BH1373 TR:Q9KD46 (EMBL:AP001511) (270 aa) fasta scores: E(): 1.7e-52, 59.144% id in 257 aa; hypothetical protein complement(1709338..1710156) Staphylococcus aureus subsp. aureus MRSA252 2861097 YP_041037.1 CDS SAR1642 NC_002952.2 1711125 1712516 D Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 1711125..1712516 Staphylococcus aureus subsp. aureus MRSA252 2861099 YP_041038.1 CDS SAR1643 NC_002952.2 1712667 1713419 R Similar to Bacillus subtilis DNA repair protein RecO SW:RECO_BACSU (P42095) (255 aa) fasta scores: E(): 3.6e-23, 28.287% id in 251 aa, and to Bacillus halodurans hypothetical protein BH1369 TR:Q9KD50 (EMBL:AP001511) (254 aa) fasta scores: E(): 3e-22, 28.629% id in 248 aa; recombination protein O complement(1712667..1713419) Staphylococcus aureus subsp. aureus MRSA252 2861100 YP_041039.1 CDS era NC_002952.2 1713441 1714340 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(1713441..1714340) Staphylococcus aureus subsp. aureus MRSA252 2859613 YP_041040.1 CDS cdd NC_002952.2 1714341 1714745 R Similar to Homo sapiens cytidine deaminase CDA SW:CDD_HUMAN (P32320) (146 aa) fasta scores: E(): 4.2e-21, 47.101% id in 138 aa, and to Bacillus subtilis cytidine deaminase Cdd SW:CDD_BACSU (P19079) (136 aa) fasta scores: E(): 7.3e-21, 50.000% id in 124 aa; cytidine deaminase complement(1714341..1714745) Staphylococcus aureus subsp. aureus MRSA252 2861355 YP_041041.1 CDS SAR1646 NC_002952.2 1714756 1715100 R Similar to Escherichia coli diacylglycerol kinase DgkA SW:KDGL_ECOLI (P00556) (121 aa) fasta scores: E(): 4.3e-07, 34.545% id in 110 aa, and to Bacillus halodurans diacylglycerol kinase BH1364 TR:Q9KD55 (EMBL:AP001511) (130 aa) fasta scores: E(): 5.4e-14, 42.857% id in 112 aa; diacylglycerol kinase complement(1714756..1715100) Staphylococcus aureus subsp. aureus MRSA252 2861101 YP_041042.1 CDS SAR1647 NC_002952.2 1715103 1715570 R Similar to Bacillus subtilis hypothetical protein YqfG SW:YQFG_BACSU (P46347) (157 aa) fasta scores: E(): 6e-29, 56.579% id in 152 aa, and to Bacillus halodurans hypothetical protein BH1363 TR:Q9KD56 (EMBL:AP001511) (159 aa) fasta scores: E(): 4.5e-25, 55.128% id in 156 aa; hypothetical protein complement(1715103..1715570) Staphylococcus aureus subsp. aureus MRSA252 2861102 YP_041043.1 CDS SAR1648 NC_002952.2 1715571 1716518 R Similar to Bacillus megaterium hypothetical protein TR:Q9ZEF6 (EMBL:AJ224829) (324 aa) fasta scores: E(): 9.3e-66, 65.372% id in 309 aa, and to Bacillus subtilis PhoH-like protein PhoH SW:PHOL_BACSU (P46343) (319 aa) fasta scores: E(): 2.5e-64, 62.903% id in 310 aa; PhoH-like protein complement(1715571..1716518) Staphylococcus aureus subsp. aureus MRSA252 2861103 YP_041044.1 CDS SAR1649 NC_002952.2 1716821 1717519 R hypothetical protein complement(1716821..1717519) Staphylococcus aureus subsp. aureus MRSA252 2861104 YP_041045.1 CDS SAR1650 NC_002952.2 1717536 1718525 R Similar to Bacillus subtilis hypothetical protein YqfA SW:YQFA_BACSU (P54466) (331 aa) fasta scores: E(): 4.4e-80, 78.019% id in 323 aa, and to Bacillus halodurans hypothetical protein BH1357 TR:Q9KD62 (EMBL:AP001511) (331 aa) fasta scores: E(): 8.3e-79, 76.161% id in 323 aa; hypothetical protein complement(1717536..1718525) Staphylococcus aureus subsp. aureus MRSA252 2861105 YP_041046.1 CDS SAR1651 NC_002952.2 1718543 1719250 R Similar to C-terminal regions of Bacillus subtilis hypothetical protein YqeZ SW:YQEZ_BACSU (P54465) (437 aa) fasta scores: E(): 2e-24, 35.000% id in 220 aa, and Bacillus halodurans hypothetical protein BH1356 TR:Q9KD63 (EMBL:AP001511) (445 aa) fasta scores: E(): 1.4e-18, 32.766% id in 235 aa; hypothetical protein complement(1718543..1719250) Staphylococcus aureus subsp. aureus MRSA252 2861106 YP_041047.1 CDS rpsU NC_002952.2 1719470 1719646 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(1719470..1719646) Staphylococcus aureus subsp. aureus MRSA252 2861457 YP_041048.1 CDS SAR1653 NC_002952.2 1719939 1721285 R Similar to Bacillus subtilis hypothetical protein YqeV SW:YQEV_BACSU (P54462) (451 aa) fasta scores: E(): 3.3e-131, 77.273% id in 440 aa, and to Bacillus halodurans hypothetical protein BH1351 TR:Q9KD68 (EMBL:AP001511) (448 aa) fasta scores: E(): 3.7e-131, 77.677% id in 439 aa; hypothetical protein complement(1719939..1721285) Staphylococcus aureus subsp. aureus MRSA252 2861107 YP_041049.1 CDS SAR1654 NC_002952.2 1721292 1722044 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1721292..1722044) Staphylococcus aureus subsp. aureus MRSA252 2861108 YP_041050.1 CDS prmA NC_002952.2 1722046 1722984 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase complement(1722046..1722984) Staphylococcus aureus subsp. aureus MRSA252 2861109 YP_041051.1 CDS dnaJ NC_002952.2 1722988 1724127 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ complement(1722988..1724127) Staphylococcus aureus subsp. aureus MRSA252 2859603 YP_041052.1 CDS dnaK NC_002952.2 1724263 1726095 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(1724263..1726095) Staphylococcus aureus subsp. aureus MRSA252 2859604 YP_041053.1 CDS grpE NC_002952.2 1726164 1726790 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(1726164..1726790) Staphylococcus aureus subsp. aureus MRSA252 2859945 YP_041054.1 CDS hrcA NC_002952.2 1726822 1727799 R Similar to Bacillus subtilis heat-inducible transcription repressor HrcA SW:HRCA_BACSU (P25499) (343 aa) fasta scores: E(): 5.1e-30, 31.138% id in 334 aa. Previously sequenced as Staphylococcus aureus heat-inducible transcription repressor HrcA SW:HRCA_STAAU (P45556) (325 aa) fasta scores: E(): 9.8e-112, 99.692% id in 325 aa; heat-inducible transcription repressor complement(1726822..1727799) Staphylococcus aureus subsp. aureus MRSA252 2859647 YP_041055.1 CDS SAR1660 NC_002952.2 1727900 1729024 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1727900..1729024) Staphylococcus aureus subsp. aureus MRSA252 2861110 YP_041056.1 CDS lepA NC_002952.2 1729531 1731354 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(1729531..1731354) Staphylococcus aureus subsp. aureus MRSA252 2859697 YP_041057.1 CDS rpsT NC_002952.2 1731700 1731951 D binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1731700..1731951 Staphylococcus aureus subsp. aureus MRSA252 2861456 YP_041058.1 CDS holA NC_002952.2 1731996 1732970 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(1731996..1732970) Staphylococcus aureus subsp. aureus MRSA252 2861111 YP_041059.1 CDS SAR1665 NC_002952.2 1733027 1735228 R Similar to Lactococcus lactis competence protein ComEC TR:Q9CER4 (EMBL:AE006407) (736 aa) fasta scores: E(): 3.9e-30, 26.139% id in 746 aa, and to Bacillus subtilis comE operon protein 3 ComE3 SW:CME3_BACSU (P39695) (776 aa) fasta scores: E(): 1.4e-23, 26.057% id in 733 aa; hypothetical protein complement(1733027..1735228) Staphylococcus aureus subsp. aureus MRSA252 2861112 YP_041060.1 CDS SAR1666 NC_002952.2 1735233 1735694 R Similar to Streptococcus pyogenes late competence protein required for DNA binding SPY1823 TR:Q99Y86 (EMBL:AE006609) (153 aa) fasta scores: E(): 2.3e-31, 56.716% id in 134 aa, and to the C-terminal region of to Saccharomyces cerevisiae deoxycytidylate deaminase DCD1 SW:DCTD_YEAST (P06773) (312 aa) fasta scores: E(): 4.9e-16, 38.000% id in 150 aa; deaminase complement(1735233..1735694) Staphylococcus aureus subsp. aureus MRSA252 2861113 YP_041061.1 CDS SAR1667 NC_002952.2 1735786 1736463 R Similar to Listeria monocytogenes competence protein 1 TR:Q9EYL7 (EMBL:AF320589) (211 aa) fasta scores: E(): 1.6e-17, 36.744% id in 215 aa, and to Bacillus subtilis comE operon protein 1 ComE1 SW:CME1_BACSU (P39694) (205 aa) fasta scores: E(): 8.9e-18, 39.779% id in 181 aa; hypothetical protein complement(1735786..1736463) Staphylococcus aureus subsp. aureus MRSA252 2861114 YP_041062.1 CDS SAR1668 NC_002952.2 1736512 1737228 R Similar to Bacillus subtilis hypothetical protein YqeM SW:YQEM_BACSU (P54458) (247 aa) fasta scores: E(): 6.8e-31, 40.909% id in 242 aa, and to Streptococcus pyogenes hypothetical protein SPY0312 TR:Q9A1E9 (EMBL:AE006496) (263 aa) fasta scores: E(): 1.3e-29, 37.037% id in 243 aa; hypothetical protein complement(1736512..1737228) Staphylococcus aureus subsp. aureus MRSA252 2861115 YP_041063.1 CDS SAR1669 NC_002952.2 1737231 1737584 R Similar to Bacillus halodurans hypothetical protein BH1328 TR:Q9KD89 (EMBL:AP001511) (117 aa) fasta scores: E(): 2.4e-26, 64.815% id in 108 aa, and to Bacillus subtilis hypothetical protein YqeL SW:YQEL_BACSU (P54457) (118 aa) fasta scores: E(): 5.7e-25, 60.550% id in 109 aa; hypothetical protein complement(1737231..1737584) Staphylococcus aureus subsp. aureus MRSA252 2861116 YP_041064.1 CDS SAR1670 NC_002952.2 1737585 1738169 R Similar to Bacillus halodurans hypothetical protein BH1327 TR:Q9KD90 (EMBL:AP001511) (187 aa) fasta scores: E(): 1.5e-24, 43.407% id in 182 aa, and to Bacillus subtilis hypothetical protein YqeK SW:YQEK_BACSU (P54456) (186 aa) fasta scores: E(): 2.4e-23, 39.891% id in 183 aa; hypothetical protein complement(1737585..1738169) Staphylococcus aureus subsp. aureus MRSA252 2861117 YP_041065.1 CDS SAR1671 NC_002952.2 1738159 1738728 R Similar to Bacillus subtilis probable nicotinate-nucleotide adenylyltransferase NadD SW:NADD_BACSU (P54455) (189 aa) fasta scores: E(): 2.2e-22, 33.511% id in 188 aa, and to Bacillus halodurans probable nicotinate-nucleotide adenylyltransferase BH1326 SW:NADD_BACHD (Q9KD91) (207 aa) fasta scores: E(): 2.9e-21, 37.500% id in 192 aa; hypothetical protein complement(1738159..1738728) Staphylococcus aureus subsp. aureus MRSA252 2861118 YP_041066.1 CDS SAR1672 NC_002952.2 1738731 1739021 R Similar to Bacillus subtilis hypothetical protein YqeI SW:YQEI_BACSU (P54454) (96 aa) fasta scores: E(): 3.8e-21, 66.667% id in 96 aa, and to Bacillus halodurans hypothetical protein BH1325 TR:Q9KD92 (EMBL:AP001511) (96 aa) fasta scores: E(): 5.2e-21, 65.625% id in 96 aa; hypothetical protein complement(1738731..1739021) Staphylococcus aureus subsp. aureus MRSA252 2861119 YP_041067.1 CDS aroE NC_002952.2 1739025 1739831 R Similar to Escherichia coli shikimate 5-dehydrogenase AroE SW:AROE_ECOLI (P15770) (272 aa) fasta scores: E(): 5.7e-21, 34.409% id in 279 aa, and to Bacillus subtilis shikimate 5-dehydrogenase AroD SW:AROE_BACSU (P54374) (280 aa) fasta scores: E(): 1.5e-31, 37.956% id in 274 aa; shikimate 5-dehydrogenase complement(1739025..1739831) Staphylococcus aureus subsp. aureus MRSA252 2859863 YP_041068.1 CDS SAR1674 NC_002952.2 1739845 1740945 R in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH complement(1739845..1740945) Staphylococcus aureus subsp. aureus MRSA252 2861120 YP_041069.1 CDS SAR1675 NC_002952.2 1740946 1741473 R Similar to Bacillus subtilis hypothetical protein YqeG SW:YQEG_BACSU (P54452) (172 aa) fasta scores: E(): 4.1e-37, 58.140% id in 172 aa, and to Bacillus halodurans hypothetical protein BH1322 TR:Q9KD95 (EMBL:AP001511) (171 aa) fasta scores: E(): 3.4e-31, 52.663% id in 169 aa; hypothetical protein complement(1740946..1741473) Staphylococcus aureus subsp. aureus MRSA252 2861121 YP_041070.1 CDS pfs NC_002952.2 1741493 1742179 R Similar to Escherichia coli 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) nucleosidase Pfs SW:MTN_ECOLI (P24247) (232 aa) fasta scores: E(): 1.2e-40, 54.185% id in 227 aa, and to Vibrio cholerae MTA/SAH nucleosidase VC2379 TR:Q9KPI8 (EMBL:AE004308) (231 aa) fasta scores: E(): 1.8e-40, 53.509% id in 228 aa; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(1741493..1742179) Staphylococcus aureus subsp. aureus MRSA252 2859898 YP_041071.1 CDS SAR1677 NC_002952.2 1742493 1742762 D No significant database matches. Doubtful CDS; hypothetical protein 1742493..1742762 Staphylococcus aureus subsp. aureus MRSA252 2861122 YP_041072.1 CDS SAR1680 NC_002952.2 1743730 1743909 R Doubtful CDS. No significant database matches; hypothetical protein complement(1743730..1743909) Staphylococcus aureus subsp. aureus MRSA252 2861124 YP_041073.1 CDS SAR1683 NC_002952.2 1745773 1747005 R Similar to Bacillus halodurans hypothetical protein BH1820 TR:Q9KBV4 (EMBL:AP001513) (385 aa) fasta scores: E(): 2.1e-74, 55.670% id in 388 aa, and to Bacillus subtilis hypothetical protein YcsG SW:YCSG_BACSU (P42964) (386 aa) fasta scores: E(): 5e-71, 54.617% id in 379 aa; hypothetical protein complement(1745773..1747005) Staphylococcus aureus subsp. aureus MRSA252 2861126 YP_041074.1 CDS SAR1684 NC_002952.2 1747017 1747769 R Similar to Bacillus halodurans lactam utilization protein BH1821 TR:Q9KBV3 (EMBL:AP001513) (257 aa) fasta scores: E(): 7.3e-54, 54.472% id in 246 aa, and to Campylobacter jejuni hypothetical protein CJ1541 TR:Q9PMC8 (EMBL:AL139078) (255 aa) fasta scores: E(): 2.4e-49, 55.422% id in 249 aa; LamB/YcsF family protein complement(1747017..1747769) Staphylococcus aureus subsp. aureus MRSA252 2861127 YP_041075.1 CDS SAR1685 NC_002952.2 1747769 1749130 R Similar to Anabaena sp biotin carboxylase AccC SW:ACCC_ANASP (Q06862) (447 aa) fasta scores: E(): 2.6e-78, 48.081% id in 443 aa, and to Lactococcus lactis biotin carboxylase AccC TR:Q9CHF3 (EMBL:AE006311) (455 aa) fasta scores: E(): 3.7e-82, 51.242% id in 443 aa; biotin carboxylase complement(1747769..1749130) Staphylococcus aureus subsp. aureus MRSA252 2861128 YP_041076.1 CDS SAR1686 NC_002952.2 1749144 1749593 R Similar to Bacillus subtilis biotin carboxyl carrier protein of acetyl-CoA carboxylase AccB SW:BCCP_BACSU (P49786) (159 aa) fasta scores: E(): 7.2e-08, 30.573% id in 157 aa, and to Aquifex aeolicus biotin carboxyl carrier protein AQ_1363 TR:O67375 (EMBL:AE000736) (154 aa) fasta scores: E(): 1e-07, 31.333% id in 150 aa; biotin carboxyl carrier protein of acetyl-CoA carboxylase complement(1749144..1749593) Staphylococcus aureus subsp. aureus MRSA252 2861129 YP_041077.1 CDS SAR1687 NC_002952.2 1749595 1750605 R Similar to Pyrococcus horikoshii hypothetical protein PH0988 TR:O58716 (EMBL:AP000004) (331 aa) fasta scores: E(): 3.2e-34, 38.014% id in 292 aa, and to Pyrococcus abyssi hypothetical protein PAB1714 TR:Q9V007 (EMBL:AJ248286) (331 aa) fasta scores: E(): 5.7e-34, 37.500% id in 304 aa; hypothetical protein complement(1749595..1750605) Staphylococcus aureus subsp. aureus MRSA252 2861130 YP_041078.1 CDS SAR1688 NC_002952.2 1750595 1751329 R Similar to Bacillus halodurans hypothetical protein BH1817 TR:Q9KBV7 (EMBL:AP001513) (225 aa) fasta scores: E(): 1.5e-34, 43.243% id in 222 aa, and to Campylobacter jejuni hypothetical protein CJ1542 TR:Q9PMC7 (EMBL:AL139078) (246 aa) fasta scores: E(): 1.5e-31, 42.672% id in 232 aa; hypothetical protein complement(1750595..1751329) Staphylococcus aureus subsp. aureus MRSA252 2859379 YP_041079.1 CDS greA NC_002952.2 1751655 1752131 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1751655..1752131) Staphylococcus aureus subsp. aureus MRSA252 2859940 YP_041080.1 CDS udk NC_002952.2 1752159 1752782 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1752159..1752782) Staphylococcus aureus subsp. aureus MRSA252 2860410 YP_041081.1 CDS SAR1691 NC_002952.2 1752782 1754050 R Similar to Bacillus subtilis hypothetical protein YrrO TR:O32034 (EMBL:Z99117) (422 aa) fasta scores: E(): 2.5e-125, 75.481% id in 416 aa, and to Bacillus halodurans protease BH1274 TR:Q9KDD9 (EMBL:AP001511) (420 aa) fasta scores: E(): 9.9e-121, 72.195% id in 410 aa; peptidase complement(1752782..1754050) Staphylococcus aureus subsp. aureus MRSA252 2859380 YP_041082.1 CDS SAR1692 NC_002952.2 1754062 1754985 R Similar to Bacillus subtilis hypothetical protein YrrN TR:O32035 (EMBL:Z99117) (309 aa) fasta scores: E(): 3.9e-66, 54.754% id in 305 aa, and to Bacillus halodurans protease BH1273 TR:Q9KDE0 (EMBL:AP001511) (309 aa) fasta scores: E(): 9.6e-65, 53.770% id in 305 aa; peptidase complement(1754062..1754985) Staphylococcus aureus subsp. aureus MRSA252 2859381 YP_041083.1 CDS SAR1693 NC_002952.2 1754988 1755626 R Similar to Bacillus subtilis hypothetical protein YrrM TR:O32036 (EMBL:Z99117) (217 aa) fasta scores: E(): 7.1e-23, 37.561% id in 205 aa, and to Bacillus halodurans O-methyltransferase BH1272 TR:Q9KDE1 (EMBL:AP001511) (223 aa) fasta scores: E(): 2e-22, 35.577% id in 208 aa; O-methyltransferase complement(1754988..1755626) Staphylococcus aureus subsp. aureus MRSA252 2859382 YP_041084.1 CDS SAR1694 NC_002952.2 1755911 1756219 R Similar to Streptococcus pyogenes hypothetical protein SPY2112 TR:Q99XP5 (EMBL:AE006631) (101 aa) fasta scores: E(): 1.8e-08, 40.196% id in 102 aa, and to Lactococcus lactis hypothetical protein YbeC TR:Q9CJ62 (EMBL:AE006252) (107 aa) fasta scores: E(): 5.5e-08, 38.235% id in 102 aa; hypothetical protein complement(1755911..1756219) Staphylococcus aureus subsp. aureus MRSA252 2859383 YP_041085.1 CDS SAR1695 NC_002952.2 1756234 1756662 R similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein complement(1756234..1756662) Staphylococcus aureus subsp. aureus MRSA252 2859384 YP_041086.1 CDS SAR1696 NC_002952.2 1756666 1756926 R Similar to Bacillus halodurans hypothetical protein BH1268 TR:Q9KDE5 (EMBL:AP001511) (90 aa) fasta scores: E(): 2.6e-15, 56.322% id in 87 aa, and to Streptococcus pyogenes hypothetical protein SPY2114 TR:Q99XP3 (EMBL:AE006631) (89 aa) fasta scores: E(): 1.2e-14, 56.410% id in 78 aa; hypothetical protein complement(1756666..1756926) Staphylococcus aureus subsp. aureus MRSA252 2859385 YP_041087.1 CDS alaS NC_002952.2 1756989 1759619 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1756989..1759619) Staphylococcus aureus subsp. aureus MRSA252 2860987 YP_041088.1 CDS SAR1698 NC_002952.2 1759962 1762439 R Similar to Bacillus subtilis hypothetical protein YrrC TR:O34481 (EMBL:Z99117) (798 aa) fasta scores: E(): 1.9e-137, 52.646% id in 756 aa, and to Streptococcus pyogenes exodeoxyribonuclease V SPY1844 TR:Q99Y68 (EMBL:AE006610) (817 aa) fasta scores: E(): 2.2e-105, 39.753% id in 810 aa; hypothetical protein complement(1759962..1762439) Staphylococcus aureus subsp. aureus MRSA252 2859386 YP_041089.1 CDS SAR1699 NC_002952.2 1762441 1763109 R Similar to Bacillus subtilis hypothetical protein YrrB TR:O34452 (EMBL:Z99117) (206 aa) fasta scores: E(): 9.8e-21, 36.946% id in 203 aa, and to Bacillus halodurans hypothetical protein BH1262 TR:Q9KDF1 (EMBL:AP001511) (214 aa) fasta scores: E(): 4.9e-20, 34.848% id in 198 aa; hypothetical protein complement(1762441..1763109) Staphylococcus aureus subsp. aureus MRSA252 2859387 YP_041090.1 CDS mnmA NC_002952.2 1763791 1764909 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1763791..1764909) Staphylococcus aureus subsp. aureus MRSA252 2859388 YP_041091.1 CDS SAR1702 NC_002952.2 1764910 1766052 R Similar to Escherichia coli Fe-S cluster formation protein, cysteine desulfurase IscS SW:ISCS_ECOLI (P39171) (404 aa) fasta scores: E(): 3.1e-50, 42.746% id in 386 aa, and to Bacillus halodurans Fe-S cluster formation protein BH1260 TR:Q9KDF3 (EMBL:AP001511) (386 aa) fasta scores: E(): 2.1e-62, 46.719% id in 381 aa; cysteine desulfurase complement(1764910..1766052) Staphylococcus aureus subsp. aureus MRSA252 2859389 YP_041092.1 CDS SAR1703 NC_002952.2 1766362 1767375 D Similar to Bacillus subtilis hypothetical protein YddN SW:YDDN_BACSU (P96651) (339 aa) fasta scores: E(): 7.4e-57, 45.593% id in 329 aa, and to Caulobacter crescentus hypothetical protein CC1957 cc1957 TR:Q9A6W9 (EMBL:AE005869) (337 aa) fasta scores: E(): 1.5e-50, 45.886% id in 316 aa; oxygenase 1766362..1767375 Staphylococcus aureus subsp. aureus MRSA252 2859390 YP_041093.1 CDS SAR1704 NC_002952.2 1767612 1767758 R hypothetical protein complement(1767612..1767758) Staphylococcus aureus subsp. aureus MRSA252 2859391 YP_041094.1 CDS SAR1705 NC_002952.2 1767798 1767980 R Similar to Streptococcus pyogenes hypothetical protein SPY1261 TR:Q99ZE6 (EMBL:AE006565) (66 aa) fasta scores: E(): 0.0004, 46.296% id in 54 aa, and to Lactococcus lactis hypothetical protein YhjA TR:Q9CHE9 (EMBL:AE006312) (79 aa) fasta scores: E(): 0.0032, 47.059% id in 51 aa. Similar to SAR0874, 79.661% identity (79.661% ungapped) in 59 aa overlap; hypothetical protein complement(1767798..1767980) Staphylococcus aureus subsp. aureus MRSA252 2859392 YP_041095.1 CDS SAR1706 NC_002952.2 1768080 1768502 R Similar to Bacillus halodurans hypothetical protein BH1259 TR:Q9KDF4 (EMBL:AP001511) (139 aa) fasta scores: E(): 3.3e-31, 65.714% id in 140 aa. N-terminus is similar to the N-terminal region of Bacillus subtilis hypothetical protein YrzC SW:YRZC_BACSU (O34527) (111 aa) fasta scores: E(): 2.8e-19, 68.132% id in 91 aa; hypothetical protein complement(1768080..1768502) Staphylococcus aureus subsp. aureus MRSA252 2859393 YP_041096.1 CDS SAR1707 NC_002952.2 1768587 1769861 D Similar to Bacillus subtilis hypothetical protein YrvN TR:O34528 (EMBL:Z99117) (421 aa) fasta scores: E(): 1.3e-98, 69.286% id in 420 aa, and to Bacillus halodurans hypothetical protein BH1257 TR:Q9KDF6 (EMBL:AP001511) (428 aa) fasta scores: E(): 3e-95, 66.507% id in 418 aa; recombination factor protein RarA 1768587..1769861 Staphylococcus aureus subsp. aureus MRSA252 2859394 YP_041097.1 CDS SAR1708 NC_002952.2 1770022 1770795 R Similar to Bacillus halodurans hypothetical protein BH1255 TR:Q9KDF8 (EMBL:AP001511) (259 aa) fasta scores: E(): 1.8e-57, 64.173% id in 254 aa. C-terminal region is similar to Bacillus subtilis hypothetical protein YrvM TR:O32037 (EMBL:Z99118) (161 aa) fasta scores: E(): 1.4e-38, 70.440% id in 159 aa; hypothetical protein complement(1770022..1770795) Staphylococcus aureus subsp. aureus MRSA252 2859395 YP_041098.1 CDS SAR1709 NC_002952.2 1771009 1771110 R Doubtful CDS. No database matches; hypothetical protein complement(1771009..1771110) Staphylococcus aureus subsp. aureus MRSA252 2859396 YP_041099.1 CDS aspS NC_002952.2 1771256 1773022 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1771256..1773022) Staphylococcus aureus subsp. aureus MRSA252 2859872 YP_041100.1 CDS hisS NC_002952.2 1773038 1774300 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1773038..1774300) Staphylococcus aureus subsp. aureus MRSA252 2860715 YP_041101.1 CDS SAR1713 NC_002952.2 1775632 1776084 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1775632..1776084) Staphylococcus aureus subsp. aureus MRSA252 2859398 YP_041102.1 CDS relA NC_002952.2 1776096 1778306 R Similar to Bacillus subtilis GTP pyrophosphokinase RelA SW:RELA_BACSU (O54408) (734 aa) fasta scores: E(): 4.2e-176, 61.111% id in 738 aa. Previously sequenced as Staphylococcus aureus GTP pyrophosphokinase RelA SW:RELA_STAAU (O32419) (736 aa) fasta scores: E(): 0, 99.864% id in 736 aa. CDS is extended at the N-terminus in comparison to the B. subtilis protein and other orthologoues. Probable alternative translational start site; GTP pyrophosphokinase complement(1776096..1778306) Staphylococcus aureus subsp. aureus MRSA252 2859305 YP_041103.1 CDS apt NC_002952.2 1778713 1779231 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1778713..1779231) Staphylococcus aureus subsp. aureus MRSA252 2860994 YP_041104.1 CDS SAR1716 NC_002952.2 1779253 1781526 R N-terminal region is similar to Escherichia coli single-stranded-DNA-specific exonuclease RecJ SW:RECJ_ECOLI (P21893) (577 aa) fasta scores: E(): 1.4e-18, 31.930% id in 570 aa. Full length CDS is similar to Bacillus halodurans single-strand DNA-specific exonuclease bh1240 TR:Q9KDH3 (EMBL:AP001511) (784 aa) fasta scores: E(): 1.8e-86, 38.831% id in 770 aa; single-stranded-DNA-specific exonuclease complement(1779253..1781526) Staphylococcus aureus subsp. aureus MRSA252 2859399 YP_041105.1 CDS secF NC_002952.2 1781729 1784008 R part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; bifunctional preprotein translocase subunit SecD/SecF complement(1781729..1784008) Staphylococcus aureus subsp. aureus MRSA252 2859135 YP_041106.1 CDS SAR1718 NC_002952.2 1784283 1784543 R Similar to Bacillus halodurans hypothetical protein BH1229 SW:YC29_BACHD (Q9KDI4) (88 aa) fasta scores: E(): 5.4e-13, 53.165% id in 79 aa, and to Bacillus subtilis hypothetical protein YrbF SW:YRBF_BACSU (O32052) (89 aa) fasta scores: E(): 1e-10, 47.436% id in 78 aa; hypothetical protein complement(1784283..1784543) Staphylococcus aureus subsp. aureus MRSA252 2859400 YP_041107.1 CDS tgt NC_002952.2 1784562 1785701 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(1784562..1785701) Staphylococcus aureus subsp. aureus MRSA252 2859524 YP_041108.1 CDS queA NC_002952.2 1785724 1786749 R Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase complement(1785724..1786749) Staphylococcus aureus subsp. aureus MRSA252 2859296 YP_041109.1 CDS ruvB NC_002952.2 1786751 1787755 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(1786751..1787755) Staphylococcus aureus subsp. aureus MRSA252 2861462 YP_041110.1 CDS ruvA NC_002952.2 1787787 1788389 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(1787787..1788389) Staphylococcus aureus subsp. aureus MRSA252 2861461 YP_041111.1 CDS SAR1723 NC_002952.2 1788403 1788861 R Similar to Bacillus subtilis possible chorismate mutase PheB SW:PHEB_BACSU (P21204) (147 aa) fasta scores: E(): 4e-17, 41.007% id in 139 aa, and to Bacillus halodurans chorismate mutase BH1214 TR:Q9KDJ9 (EMBL:AP001511) (147 aa) fasta scores: E(): 2.2e-14, 39.007% id in 141 aa; hypothetical protein complement(1788403..1788861) Staphylococcus aureus subsp. aureus MRSA252 2859401 YP_041112.1 CDS obgE NC_002952.2 1788871 1790163 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(1788871..1790163) Staphylococcus aureus subsp. aureus MRSA252 2859173 YP_041113.1 CDS rpmA NC_002952.2 1790650 1790934 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(1790650..1790934) Staphylococcus aureus subsp. aureus MRSA252 2860921 YP_041114.1 CDS SAR1726 NC_002952.2 1790946 1791266 R Similar to Bacillus subtilis hypothetical protein YsxB SW:YSXB_BACSU (P26942) (112 aa) fasta scores: E(): 3.4e-11, 38.318% id in 107 aa, and to Bacillus halodurans hypothetical protein BH3010 TR:Q9K8J6 (EMBL:AP001517) (113 aa) fasta scores: E(): 1.6e-10, 40.000% id in 110 aa; hypothetical protein complement(1790946..1791266) Staphylococcus aureus subsp. aureus MRSA252 2859402 YP_041115.1 CDS rplU NC_002952.2 1791272 1791580 R Similar to Escherichia coli 50S ribosomal protein L21 RplU SW:RL21_ECOLI (P02422) (103 aa) fasta scores: E(): 6.6e-14, 41.748% id in 103 aa. Previously sequenced as Staphylococcus aureus 50S ribosomal protein L21 TR:AAK52740 (EMBL:AF349567) (102 aa) fasta scores: E(): 2e-35, 99.020% id in 102 aa; 50S ribosomal protein L21 complement(1791272..1791580) Staphylococcus aureus subsp. aureus MRSA252 2860916 YP_041116.1 CDS SAR1728 NC_002952.2 1791873 1792403 R Similar to Lactococcus lactis cell shape determining protein MreD TR:Q9CDJ0 (EMBL:AE006452) (175 aa) fasta scores: E(): 1.5e-06, 31.977% id in 172 aa, and to Bacillus subtilis rod shape-determining protein MreD SW:MRED_BACSU (Q01467) (172 aa) fasta scores: E(): 2.2e-05, 25.989% id in 177 aa; hypothetical protein complement(1791873..1792403) Staphylococcus aureus subsp. aureus MRSA252 2859403 YP_041117.1 CDS SAR1729 NC_002952.2 1792403 1793245 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(1792403..1793245) Staphylococcus aureus subsp. aureus MRSA252 2859404 YP_041118.1 CDS SAR1729a NC_002952.2 1793445 1793564 R Doubtful CDS. No database matches; hypothetical protein complement(1793445..1793564) Staphylococcus aureus subsp. aureus MRSA252 2859405 YP_041119.1 CDS SAR1730 NC_002952.2 1793638 1794111 R hypothetical protein complement(1793638..1794111) Staphylococcus aureus subsp. aureus MRSA252 2859406 YP_041120.1 CDS SAR1731 NC_002952.2 1794253 1794468 D Doubtful CDS. No significant database matches; hypothetical protein 1794253..1794468 Staphylococcus aureus subsp. aureus MRSA252 2859407 YP_041121.1 CDS SAR1732 NC_002952.2 1794584 1794868 R hypothetical protein complement(1794584..1794868) Staphylococcus aureus subsp. aureus MRSA252 2859408 YP_041122.1 CDS SAR1734 NC_002952.2 1795317 1795979 R Highly similar to Staphylococcus aureus transposon Tn554 hypothetical protein TR:Q48363 (EMBL:X03216) (220 aa) fasta scores: E(): 2.8e-82, 99.545% id in 220 aa; hypothetical protein complement(1795317..1795979) Staphylococcus aureus subsp. aureus MRSA252 2859409 YP_041123.1 CDS ermA2 NC_002952.2 1796513 1797244 D Identical to Staphylococcus aureus macrolide-lincosamide-streptogramin B resistance protein, rRNA adenine N-6-methyltransferase ErmA SW:ERM1_STAAU (P06699) (243 aa) fasta scores: E(): 1.7e-90, 100.000% id in 243 aa. Similar to Lactobacillus reuteri rRNA adenine N-6-methyltransferase ErmGT SW:ERMG_LACRE (Q00014) (244 aa) fasta scores: E(): 2.6e-54, 61.728% id in 243 aa; rRNA adenine N-6-methyltransferase 2 1796513..1797244 Staphylococcus aureus subsp. aureus MRSA252 2859615 YP_041124.1 CDS spc2 NC_002952.2 1797370 1798152 R Identical to Staphylococcus aureus streptomycin 3''-adenylyltransferase Spc SW:S3AD_STAAU (P04827) (260 aa) fasta scores: E(): 3.5e-100, 100.000% id in 260 aa. Similar to Streptomyces coelicolor nucleotidyltransferase SCD19.10 TR:Q9F2Z2 (EMBL:AL392149) (257 aa) fasta scores: E(): 4.4e-34, 44.493% id in 227 aa; streptomycin 3''-adenylyltransferase 2 complement(1797370..1798152) Staphylococcus aureus subsp. aureus MRSA252 2859154 YP_041125.1 CDS tnpC2 NC_002952.2 1798303 1798680 R Identical to Staphylococcus aureus transposase C from transposon Tn554 TnpC SW:TRAC_STAAU (P06698) (125 aa) fasta scores: E(): 1.1e-36, 100.000% id in 125 aa. Similar to Staphylococcus aureus transposase C from transposon psiTn554 TnpC SW:TNPF_STAAU (P37376) (125 aa) fasta scores: E(): 8e-34, 93.600% id in 125 aa; transposase C 2 complement(1798303..1798680) Staphylococcus aureus subsp. aureus MRSA252 2859542 YP_041126.1 CDS tnpB2 NC_002952.2 1798687 1800579 R Identical to Staphylococcus aureus transposase B from transposon Tn554 TnpB SW:TNPB_STAAU (P06697) (630 aa) fasta scores: E(): 0, 100.000% id in 630 aa. Similar to Staphylococcus aureus transposase B from transposon psiTn554 TnpB SW:TNPE_STAAU (P37375) (630 aa) fasta scores: E(): 0, 96.032% id in 630 aa; transposase B 2 complement(1798687..1800579) Staphylococcus aureus subsp. aureus MRSA252 2859540 YP_041127.1 CDS tnpA2 NC_002952.2 1800576 1801661 R Highly similar to Staphylococcus aureus transposase A from transposon Tn554 TnpA SW:TNPA_STAAU (P06696) (361 aa) fasta scores: E(): 6.1e-137, 99.723% id in 361 aa; transposase A 2 complement(1800576..1801661) Staphylococcus aureus subsp. aureus MRSA252 2859538 YP_041128.1 CDS SAR1741 NC_002952.2 1802331 1803038 R Similar to Vibrio cholerae leader peptidase TcpJ TR:AAK20796 (EMBL:AF325734) (253 aa) fasta scores: E(): 4.1e-07, 27.311% id in 238 aa, and to Thermotoga maritima type IV prepilin peptidase TM1696 TR:Q9X222 (EMBL:AE001810) (240 aa) fasta scores: E(): 3.2e-08, 27.727% id in 220 aa; type III leader peptidase complement(1802331..1803038) Staphylococcus aureus subsp. aureus MRSA252 2859410 YP_041129.1 CDS folC NC_002952.2 1803299 1804570 R Similar to Lactobacillus casei folylpolyglutamate synthase Fgs SW:FOLC_LACCA (P15925) (428 aa) fasta scores: E(): 4.5e-36, 32.634% id in 429 aa, and to Bacillus subtilis folylpolyglutamate synthase FolC SW:FOLC_BACSU (Q05865) (430 aa) fasta scores: E(): 3.3e-59, 43.091% id in 427 aa; folylpolyglutamate synthase complement(1803299..1804570) Staphylococcus aureus subsp. aureus MRSA252 2860676 YP_041130.1 CDS valS NC_002952.2 1804583 1807213 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(1804583..1807213) Staphylococcus aureus subsp. aureus MRSA252 2860426 YP_041131.1 CDS tag NC_002952.2 1807616 1808176 D Similar to Escherichia coli DNA-3-methyladenine glycosylase I Tag SW:3MG1_ECOLI (P05100) (187 aa) fasta scores: E(): 9.8e-30, 43.169% id in 183 aa, and to Haemophilus influenzae DNA-3-methyladenine glycosylase Tag SW:3MGA_HAEIN (P44321) (185 aa) fasta scores: E(): 1.6e-31, 46.369% id in 179 aa; DNA-3-methyladenine glycosylase I 1807616..1808176 Staphylococcus aureus subsp. aureus MRSA252 2859513 YP_041132.1 CDS SAR1745 NC_002952.2 1808399 1809472 R Similar to Escherichia coli, regulator of aidB, transport protein AbrB SW:ABRB_ECOLI (P75747) (348 aa) fasta scores: E(): 3.2e-15, 24.571% id in 350 aa, and to Bacillus subtilis hypothetical protein YhjN TR:O07568 (EMBL:Y14081) (384 aa) fasta scores: E(): 3.5e-08, 22.977% id in 309 aa; hypothetical protein complement(1808399..1809472) Staphylococcus aureus subsp. aureus MRSA252 2859411 YP_041134.1 CDS hemL NC_002952.2 1809667 1810953 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(1809667..1810953) Staphylococcus aureus subsp. aureus MRSA252 2860706 YP_041135.1 CDS hemB NC_002952.2 1811001 1811975 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(1811001..1811975) Staphylococcus aureus subsp. aureus MRSA252 2860701 YP_041136.1 CDS hemD NC_002952.2 1811978 1812646 R Previously sequenced as Staphylococcus aureus uroporphyrinogen III synthase HemD TR:O34091 (EMBL:U89396) (222 aa) fasta scores: E(): 2.7e-79, 98.649% id in 222 aa. Similar to Bacillus halodurans uroporphyrinogen III cosynthase BH3045 TR:Q9K8G1 (EMBL:AP001517) (253 aa) fasta scores: E(): 2.6e-08, 27.731% id in 238 aa; uroporphyrinogen III synthase complement(1811978..1812646) Staphylococcus aureus subsp. aureus MRSA252 2860703 YP_041137.1 CDS hemC NC_002952.2 1812668 1813594 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(1812668..1813594) Staphylococcus aureus subsp. aureus MRSA252 2860702 YP_041138.1 CDS SAR1751 NC_002952.2 1813636 1814451 R Similar to Bacillus subtilis protein membrane-bound protein HemX SW:HEMX_BACSU (P16645) (276 aa) fasta scores: E(): 4.3e-27, 33.585% id in 265 aa, and to Bacillus stearothermophilus hypothetical protein HemX TR:O69100 (EMBL:AF064058) (273 aa) fasta scores: E(): 5.2e-26, 33.588% id in 262 aa; hypothetical protein complement(1813636..1814451) Staphylococcus aureus subsp. aureus MRSA252 2859413 YP_041139.1 CDS hemA NC_002952.2 1814473 1815819 R catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase complement(1814473..1815819) Staphylococcus aureus subsp. aureus MRSA252 2860700 YP_041140.1 CDS engB NC_002952.2 1816036 1816626 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(1816036..1816626) Staphylococcus aureus subsp. aureus MRSA252 2859414 YP_041141.1 CDS clpX NC_002952.2 1816780 1818042 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1816780..1818042) Staphylococcus aureus subsp. aureus MRSA252 2859237 YP_041142.1 CDS tig NC_002952.2 1818193 1819494 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(1818193..1819494) Staphylococcus aureus subsp. aureus MRSA252 2859534 YP_041143.1 CDS SAR1756 NC_002952.2 1819657 1820586 R hypothetical protein complement(1819657..1820586) Staphylococcus aureus subsp. aureus MRSA252 2859415 YP_041144.1 CDS SAR1757 NC_002952.2 1820605 1821213 R Similar to Bacillus subtilis hypothetical protein YmaB SW:YMAB_BACSU (P50619) (206 aa) fasta scores: E(): 1.8e-28, 42.23% id in 206 aa, and to Thermotoga maritima conserved hypothetical protein TM1382 TR:Q9X1A2 (EMBL:AE001791) (199 aa) fasta scores: E(): 5.5e-10, 30.05% id in 193 aa; hypothetical protein complement(1820605..1821213) Staphylococcus aureus subsp. aureus MRSA252 2859416 YP_041145.1 CDS rplT NC_002952.2 1821355 1821711 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(1821355..1821711) Staphylococcus aureus subsp. aureus MRSA252 2860915 YP_041146.1 CDS rpmI NC_002952.2 1821758 1821958 R Similar to Bacillus stearothermophilus 50S ribosomal protein L35 RpmI SW:RL35_BACST (P13069) (65 aa) fasta scores: E(): 1.8e-15, 72.13% id in 61 aa, and to Bacillus subtilis 50S ribosomal protein L35 RpmI SW:RL35_BACSU (P55874) (65 aa) fasta scores: E(): 9.1e-16, 70.76% id in 65 aa; 50S ribosomal protein L35 complement(1821758..1821958) Staphylococcus aureus subsp. aureus MRSA252 2860166 YP_041147.1 CDS infC NC_002952.2 1821987 1822514 R IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 complement(1821987..1822514) Staphylococcus aureus subsp. aureus MRSA252 2859669 YP_041148.1 CDS lysP NC_002952.2 1822743 1824236 R Similar to Escherichia coli lysine-specific permease LysP SW:LYSP_ECOLI (P25737) (488 aa) fasta scores: E(): 2.4e-89, 51.77% id in 479 aa, and to Lactococcus lactis lysine specific permease LysP TR:Q9CDM6 (EMBL:AE006448) (506 aa) fasta scores: E(): 9.8e-99, 55.19% id in 491 aa; lysine-specific permease complement(1822743..1824236) Staphylococcus aureus subsp. aureus MRSA252 2859814 YP_041149.1 CDS thrS NC_002952.2 1824663 1826600 R catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase complement(1824663..1826600) Staphylococcus aureus subsp. aureus MRSA252 2859532 YP_041150.1 CDS dnaI NC_002952.2 1827013 1827933 R Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI complement(1827013..1827933) Staphylococcus aureus subsp. aureus MRSA252 2859602 YP_041151.1 CDS dnaB NC_002952.2 1827933 1829333 R Similar to Bacillus subtilis replication initiation and membrane attachment protein DnaB SW:DNAB_BACSU (P07908) (472 aa) fasta scores: E(): 1.7e-18, 29% id in 462 aa, and to Bacillus halodurans chromosome replication initiation/membrane attachment protein BH3145 TR:Q9K862 (EMBL:AP001517) (485 aa) fasta scores: E(): 9e-08, 26.81% id in 481 aa; chromosome replication initiation/membrane attachment protein complement(1827933..1829333) Staphylococcus aureus subsp. aureus MRSA252 2859598 YP_041152.1 CDS nrdR NC_002952.2 1829334 1829804 R Similar to Bacillus halodurans hypothetical protein BH3146 TR:Q9K861 (EMBL:AP001517) (153 aa) fasta scores: E(): 5.3e-30, 54.9% id in 153 aa, and to Streptococcus pyogenes hypothetical protein SPY0338 TR:Q9A1D3 (EMBL:AE006498) (164 aa) fasta scores: E(): 6.4e-30, 57.14% id in 147 aa; NrdR family transcriptional regulator complement(1829334..1829804) Staphylococcus aureus subsp. aureus MRSA252 2859417 YP_041153.1 CDS gap2 NC_002952.2 1830014 1831039 R Similar to Bacillus stearothermophilus glyceraldehyde 3-phosphate dehydrogenase Gap SW:G3P_BACST (P00362) (334 aa) fasta scores: E(): 1.6e-63, 54.21% id in 332 aa, and to Bacillus subtilis glyceraldehyde 3-phosphate dehydrogenase 2 GapB SW:G3P2_BACSU (O34425) (340 aa) fasta scores: E(): 3e-77, 62.17% id in 341 aa; glyceraldehyde 3-phosphate dehydrogenase 2 complement(1830014..1831039) Staphylococcus aureus subsp. aureus MRSA252 2860689 YP_041154.1 CDS coaE NC_002952.2 1831209 1831832 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(1831209..1831832) Staphylococcus aureus subsp. aureus MRSA252 2859241 YP_041155.1 CDS SAR1768 NC_002952.2 1831848 1832720 R Similar to Escherichia coli formamidopyrimidine-DNA glycosylase MutM SW:FPG_ECOLI (P05523) (269 aa) fasta scores: E(): 7.9e-21, 34.81% id in 293 aa, and to Caulobacter crescentus formamidopyrimidine-DNA glycosylase CC3707 TR:Q9A259 (EMBL:AE006028) (315 aa) fasta scores: E(): 9.2e-23, 31.02% id in 303 aa; formamidopyrimidine-DNA glycosylase complement(1831848..1832720) Staphylococcus aureus subsp. aureus MRSA252 2859418 YP_041156.1 CDS polA NC_002952.2 1832736 1835366 R Similar to Bacillus stearothermophilus DNA polymerase I PolA SW:DPO1_BACST (P52026) (876 aa) fasta scores: E(): 5.7e-169, 55.79% id in 880 aa, and to Bacillus subtilis DNA polymerase I PolA SW:DPO1_BACSU (O34996) (880 aa) fasta scores: E(): 2.2e-179, 59.68% id in 878 aa; DNA polymerase I complement(1832736..1835366) Staphylococcus aureus subsp. aureus MRSA252 2861011 YP_041157.1 CDS SAR1770 NC_002952.2 1835659 1837146 R hypothetical protein complement(1835659..1837146) Staphylococcus aureus subsp. aureus MRSA252 2861580 YP_041158.1 CDS phoR NC_002952.2 1837647 1839311 R Two-component regulatory system family, sensor kinase. Similar to Bacillus subtilis alkaline phosphatase synthesis sensor protein PhoR SW:PHOR_BACSU (P23545) (579 aa) fasta scores: E(): 6.3e-53, 35.06% id in 579 aa, and to Bacillus halodurans two-component sensor histidine kinase involved in phosphate regulation BH3156 TR:Q9K851 (EMBL:AP001517) (589 aa) fasta scores: E(): 6.4e-53, 34.63% id in 589 aa; alkaline phosphatase synthesis sensor protein complement(1837647..1839311) Staphylococcus aureus subsp. aureus MRSA252 2859906 YP_041159.1 CDS phoP NC_002952.2 1839311 1840012 R Two-component regulatory system family, response regulator protein. Similar to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 1.9e-59, 67.51% id in 237 aa, and to Bacillus halodurans two-component response regulator involved in phosphate regulation BH3157 TR:Q9K850 (EMBL:AP001517) (239 aa) fasta scores: E(): 5.8e-56, 63.98% id in 236 aa. Similar to SAR0018, 52.155% identity (52.838% ungapped) in 232 aa overlap; alkaline phosphatase synthesis transcriptional regulatory protein complement(1839311..1840012) Staphylococcus aureus subsp. aureus MRSA252 2859905 YP_041160.1 CDS citC NC_002952.2 1840402 1841670 R Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase complement(1840402..1841670) Staphylococcus aureus subsp. aureus MRSA252 2861358 YP_041161.1 CDS citZ NC_002952.2 1841719 1842840 R catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase complement(1841719..1842840) Staphylococcus aureus subsp. aureus MRSA252 2861360 YP_041162.1 CDS cycA NC_002952.2 1843188 1844549 D Similar to Escherichia coli D-serine/D-alanine/glycine transporter CycA SW:CYCA_ECOLI (P39312) (470 aa) fasta scores: E(): 9.9e-92, 52.22% id in 450 aa, and to Bacillus subtilis hypothetical transport protein YdgF SW:YDGF_BACSU (P96704) (458 aa) fasta scores: E(): 1.3e-86, 50.22% id in 440 aa. Smilar to SAR2528, 65.410% identity (65.556% ungapped) in 451 aa overlap; D-serine/D-alanine/glycine transporter 1843188..1844549 Staphylococcus aureus subsp. aureus MRSA252 2859255 YP_041163.1 CDS pyk NC_002952.2 1844896 1846653 R Similar to Bacillus licheniformis pyruvate kinase Pyk SW:KPYK_BACLI (P51181) (585 aa) fasta scores: E(): 2.9e-125, 62.28% id in 586 aa, and to Escherichia coli, and pyruvate kinase I PykF SW:KPY1_ECOLI (P14178) (470 aa) fasta scores: E(): 9.9e-72, 48.53% id in 478 aa; pyruvate kinase complement(1844896..1846653) Staphylococcus aureus subsp. aureus MRSA252 2861244 YP_041164.1 CDS pfkA NC_002952.2 1846675 1847643 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(1846675..1847643) Staphylococcus aureus subsp. aureus MRSA252 2859897 YP_041165.1 CDS accA NC_002952.2 1847912 1848856 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha complement(1847912..1848856) Staphylococcus aureus subsp. aureus MRSA252 2859052 YP_041166.1 CDS accD NC_002952.2 1848856 1849713 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(1848856..1849713) Staphylococcus aureus subsp. aureus MRSA252 2859055 YP_041167.1 CDS SAR1780 NC_002952.2 1849908 1851137 R Similar to the C-terminal region of Bacillus stearothermophilus NAD-dependent malic enzyme SW:MAOX_BACST (P16468) (478 aa) fasta scores: E(): 2.8e-76, 56.64% id in 399 aa, and to the full length Bacillus subtilis hypothetical protein YtsJ TR:O34962 (EMBL:AF008220) (410 aa) fasta scores: E(): 8.1e-111, 74.38% id in 406 aa; NAD-dependent malic enzyme complement(1849908..1851137) Staphylococcus aureus subsp. aureus MRSA252 2861581 YP_041168.1 CDS dnaE NC_002952.2 1851585 1854782 R Previously sequenced as Staphylococcus aureus DNA polymerase III alpha subunit DnaE SW:DP3A_STAAU (Q9F1K0) (1065 aa) fasta scores: E(): 0, 96.71% id in 1065 aa. Similar to Bacillus subtilis DNA polymerase III alpha subunit DnaE SW:DP3A_BACSU (O34623) (1115 aa) fasta scores: E(): 2.1e-131, 40.62% id in 1083 aa; DNA polymerase III subunit alpha complement(1851585..1854782) Staphylococcus aureus subsp. aureus MRSA252 2859600 YP_041169.1 CDS SAR1782 NC_002952.2 1854803 1855744 R Similar to Bacillus subtilis hypothetical protein YtqI TR:O34600 (EMBL:AF008220) (313 aa) fasta scores: E(): 2.7e-56, 49.5% id in 305 aa, and to Bacillus halodurans hypothetical protein BH3173 TR:Q9K834 (EMBL:AP001518) (314 aa) fasta scores: E(): 1.7e-52, 45.57% id in 305 aa; hypothetical protein complement(1854803..1855744) Staphylococcus aureus subsp. aureus MRSA252 2861582 YP_041170.1 CDS SAR1783 NC_002952.2 1856055 1857353 R Similar to Bacillus halodurans BH3175 TR:Q9K832 (EMBL:AP001518) (435 aa) fasta scores: E(): 1.5e-76, 47.11% id in 433 aa, and to Bacillus subtilis YtoI TR:O34921 (EMBL:AF008220) (439 aa) fasta scores: E(): 5.7e-72, 45.74% id in 435 aa; DNA-binding protein complement(1856055..1857353) Staphylococcus aureus subsp. aureus MRSA252 2861583 YP_041171.1 CDS SAR1784 NC_002952.2 1857558 1857971 D Similar to Bacillus halodurans hypothetical protein BH0415 TR:Q9KFR2 (EMBL:AP001508) (137 aa) fasta scores: E(): 6.7e-08, 32.35% id in 136 aa, and to Sulfolobus solfataricus hypothetical protein SSO2778 TR:AAK42888 (EMBL:AE006871) (139 aa) fasta scores: E(): 0.0003, 26.42% id in 140 aa; universal stress protein 1857558..1857971 Staphylococcus aureus subsp. aureus MRSA252 2861584 YP_041172.1 CDS SAR1785 NC_002952.2 1858278 1858967 R catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins; metal-dependent hydrolase complement(1858278..1858967) Staphylococcus aureus subsp. aureus MRSA252 2861585 YP_041173.1 CDS SAR1786 NC_002952.2 1859142 1860197 D Similar to Lactobacillus delbrueckii Xaa-Pro dipeptidase PepQ SW:PEPQ_LACDE (Q9S6S1) (368 aa) fasta scores: E(): 7.1e-40, 43.13% id in 357 aa, and to Bacillus halodurans prolidase BH3179 TR:Q9K828 (EMBL:AP001518) (364 aa) fasta scores: E(): 3.5e-58, 43.01% id in 358 aa; metallopeptidase 1859142..1860197 Staphylococcus aureus subsp. aureus MRSA252 2861586 YP_041174.1 CDS ald1 NC_002952.2 1860507 1861625 R Similar to Bacillus subtilis alanine dehydrogenase Ald SW:DHA_BACSU (Q08352) (378 aa) fasta scores: E(): 4.4e-83, 66.3% id in 371 aa, and to Enterobacter aerogenes alanine dehydrogenase AlaDH TR:Q9WX54 (EMBL:AB013821) (377 aa) fasta scores: E(): 1.1e-84, 65.76% id in 371 aa; alanine dehydrogenase complement(1860507..1861625) Staphylococcus aureus subsp. aureus MRSA252 2860988 YP_041175.1 CDS SAR1788 NC_002952.2 1861766 1862266 D Similar to Lactococcus lactis hypothetical protein YtaA TR:Q9CEK4 (EMBL:AE006413) (145 aa) fasta scores: E(): 9.2e-22, 48.57% id in 140 aa, and to Bacillus halodurans hypothetical protein BH3184 TR:Q9K823 (EMBL:AP001518) (147 aa) fasta scores: E(): 3.6e-21, 48.95% id in 143 aa; universal stress protein 1861766..1862266 Staphylococcus aureus subsp. aureus MRSA252 2861587 YP_041176.1 CDS ackA NC_002952.2 1862513 1863715 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(1862513..1863715) Staphylococcus aureus subsp. aureus MRSA252 2859056 YP_041177.1 CDS SAR1790 NC_002952.2 1863802 1864749 R Similar to the C-terminal region of Escherichia coli type I restriction enzyme EcoEI M protein HsdM SW:T1ME_ECOLI (Q47282) (490 aa) fasta scores: E(): 0.002, 23.94% id in 309 aa, and to the full length Bacillus subtilis hypothetical protein YtxK SW:YTXK_BACSU (P37876) (329 aa) fasta scores: E(): 3.4e-33, 35.09% id in 322 aa; hypothetical protein complement(1863802..1864749) Staphylococcus aureus subsp. aureus MRSA252 2861588 YP_041178.1 CDS tpx NC_002952.2 1864872 1865366 R antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase complement(1864872..1865366) Staphylococcus aureus subsp. aureus MRSA252 2861589 YP_041179.1 CDS SAR1792 NC_002952.2 1865464 1866234 R Similar to Bacillus halodurans hypothetical protein BH2122 TR:Q9KB14 (EMBL:AP001514) (259 aa) fasta scores: E(): 1.4e-41, 49.21% id in 256 aa, and to Pasteurella multocida hypothetical protein PM0361 TR:Q9CNR5 (EMBL:AE006072) (254 aa) fasta scores: E(): 1.1e-26, 33.98% id in 256 aa; hypothetical protein complement(1865464..1866234) Staphylococcus aureus subsp. aureus MRSA252 2861590 YP_041180.1 CDS thiI NC_002952.2 1866278 1867501 R Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI complement(1866278..1867501) Staphylococcus aureus subsp. aureus MRSA252 2859527 YP_041181.1 CDS SAR1794 NC_002952.2 1867501 1868640 R Similar to Escherichia coli cysteine desulfurase IscS SW:ISCS_ECOLI (P39171) (404 aa) fasta scores: E(): 3.5e-36, 38.14% id in 367 aa, and to Bacillus halodurans L-cysteine sulfurtransferase BZ3204 TR:Q9K803 (EMBL:AP001518) (380 aa) fasta scores: E(): 2.8e-46, 37.69% id in 382 aa; aminotransferase class-V protein complement(1867501..1868640) Staphylococcus aureus subsp. aureus MRSA252 2861591 YP_041182.1 CDS SAR1795 NC_002952.2 1869008 1870702 R acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA complement(1869008..1870702) Staphylococcus aureus subsp. aureus MRSA252 2861592 YP_041183.1 CDS SAR1796 NC_002952.2 1870839 1871303 D Similar to Bacillus halodurans hypothetical protein BH3208 TR:Q9K7Z9 (EMBL:AP001518) (160 aa) fasta scores: E(): 1.6e-31, 56.55% id in 145 aa, and to Xylella fastidiosa hypothetical protein XF1230 TR:Q9PDZ8 (EMBL:AE003957) (162 aa) fasta scores: E(): 2e-28, 48.36% id in 153 aa; hypothetical protein 1870839..1871303 Staphylococcus aureus subsp. aureus MRSA252 2861593 YP_041184.1 CDS rpsD NC_002952.2 1871547 1872149 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1871547..1872149 Staphylococcus aureus subsp. aureus MRSA252 2860175 YP_041185.1 CDS SAR1798 NC_002952.2 1872365 1873108 R Similar to Bacillus subtilis glycerophosphoryl diester phosphodiesterase GlpQ SW:GLPQ_BACSU (P37965) (293 aa) fasta scores: E(): 1.1e-14, 33.59% id in 256 aa, and to Bacillus subtilis hypothetical protein YhdW TR:O07592 (EMBL:Y14082) (243 aa) fasta scores: E(): 3.7e-25, 35.41% id in 240 aa; hypothetical protein complement(1872365..1873108) Staphylococcus aureus subsp. aureus MRSA252 2861594 YP_041186.1 CDS SAR1799 NC_002952.2 1873188 1873634 D Similar to Xanthomonas campestris organic hydroperoxide resistance protein Ohr SW:OHR_XANCH (O68390) (142 aa) fasta scores: E(): 0.00011, 27.85% id in 140 aa, and to Bacillus subtilis hypothetical protein YmaD TR:O31790 (EMBL:Z99113) (150 aa) fasta scores: E(): 2.6e-17, 38.29% id in 141 aa; OsmC-like protein 1873188..1873634 Staphylococcus aureus subsp. aureus MRSA252 2861595 YP_041187.1 CDS SAR1800 NC_002952.2 1873749 1874909 D Similar to Synechococcus sp soluble hydrogenase, small subunit SW:DHSS_SYNP1 (P14776) (384 aa) fasta scores: E(): 2.2e-50, 39.68% id in 383 aa, and to Anabaena cylindrica soluble hydrogenase subunit SW:DHSS_ANACY (P16421) (383 aa) fasta scores: E(): 1.6e-49, 38.25% id in 379 aa; soluble hydrogenase subunit 1873749..1874909 Staphylococcus aureus subsp. aureus MRSA252 2861596 YP_041188.1 CDS SAR1801 NC_002952.2 1874896 1876500 D catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 1874896..1876500 Staphylococcus aureus subsp. aureus MRSA252 2861597 YP_041189.1 CDS SAR1802 NC_002952.2 1876650 1877780 R hypothetical protein complement(1876650..1877780) Staphylococcus aureus subsp. aureus MRSA252 2861598 YP_041190.1 CDS SAR1803 NC_002952.2 1877886 1879352 R Similar to N-terminal region of Escherichia coli PTS system, N-acetylglucosamine-specific IIABC component NagE SW:PTAA_ECOLI (P09323) (648 aa) fasta scores: E(): 6.8e-53, 41.58% id in 493 aa, and to full length Pasteurella multocida hypothetical protein PM0876 TR:Q9CMF3 (EMBL:AE006126) (485 aa) fasta scores: E(): 2.1e-77, 48.58% id in 496 aa; PTS system IIBC component complement(1877886..1879352) Staphylococcus aureus subsp. aureus MRSA252 2861599 YP_041191.1 CDS SAR1804 NC_002952.2 1879480 1880097 R Similar to Bacillus subtilis hypothetical protein YhdO TR:O07584 (EMBL:Y14082) (199 aa) fasta scores: E(): 3.4e-31, 47.03% id in 202 aa, and to Lactococcus lactis hypothetical protein YbbE TR:Q9CJ88 (EMBL:AE006249) (213 aa) fasta scores: E(): 5.1e-18, 37.81% id in 201 aa; acyltransferase complement(1879480..1880097) Staphylococcus aureus subsp. aureus MRSA252 2861600 YP_041192.1 CDS SAR1805 NC_002952.2 1880269 1881543 D Similar to Lactobacillus helveticus trypsin-like serine protease HtrA TR:Q9Z4H7 (EMBL:AJ005672) (412 aa) fasta scores: E(): 1.7e-40, 41.88% id in 413 aa, and to Bacillus subtilis hypothetical protein YkdA TR:O34358 (EMBL:AJ002571) (449 aa) fasta scores: E(): 6.2e-39, 39.37% id in 419 aa; protease 1880269..1881543 Staphylococcus aureus subsp. aureus MRSA252 2861601 YP_041193.1 CDS tyrS NC_002952.2 1881637 1882899 R Similar to Bacillus stearothermophilus tyrosyl-tRNA synthetase TyrS SW:SYY_BACST (P00952) (419 aa) fasta scores: E(): 4.8e-101, 61.05% id in 416 aa, and to Bacillus caldotenax tyrosyl-tRNA synthetase TyrS SW:SYY_BACCA (P04077) (419 aa) fasta scores: E(): 2.6e-100, 60.81% id in 416 aa; tyrosyl-tRNA synthetase complement(1881637..1882899) Staphylococcus aureus subsp. aureus MRSA252 2860409 YP_041194.1 CDS SAR1807 NC_002952.2 1883280 1884185 D Possible gene remnant. Similar to the N-terminal regions of Bacillus subtilis penicillin-binding protein 1A/1B PonA SW:PBPA_BACSU (P39793) (914 aa) fasta scores: E(): 3.6e-15, 32.23% id in 273 aa, and Streptococcus pyogenes penicillin-binding protein 1B SPY0097 TR:Q9A1U2 (EMBL:AE006480) (770 aa) fasta scores: E(): 4.5e-32, 37.73% id in 265 aa. Full length CDS is similar to Staphylococcus epidermidis SgtA protein SE1407 SWALL:Q8CNW0 (EMBL:AE016748) (301 aa) fasta scores: E(): 2.1e-70, 63.63% id in 297 aa; transglycosylase 1883280..1884185 Staphylococcus aureus subsp. aureus MRSA252 2861602 YP_041195.1 CDS SAR1809a NC_002952.2 1887056 1887151 D Doubtful CDS; hypothetical protein 1887056..1887151 Staphylococcus aureus subsp. aureus MRSA252 2861603 YP_041196.1 CDS fhs NC_002952.2 1887397 1889064 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1887397..1889064) Staphylococcus aureus subsp. aureus MRSA252 2860663 YP_041197.1 CDS acsA NC_002952.2 1889504 1891210 R Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase complement(1889504..1891210) Staphylococcus aureus subsp. aureus MRSA252 2859059 YP_041198.1 CDS acuA NC_002952.2 1891379 1892011 D Similar to Bacillus subtilis acetoin utilization protein AcuA SW:ACUA_BACSU (P39065) (210 aa) fasta scores: E(): 1.4e-43, 51.9% id in 210 aa, and to Bacillus halodurans acetoin dehydrogenase BH3235 TR:Q9K7X3 (EMBL:AP001518) (210 aa) fasta scores: E(): 1.2e-44, 52.85% id in 210 aa; acetoin utilization protein 1891379..1892011 Staphylococcus aureus subsp. aureus MRSA252 2859060 YP_041199.1 CDS SAR1813 NC_002952.2 1892036 1893205 D Similar to Bacillus subtilis acetoin utilization protein AcuC SW:ACUC_BACSU (P39067) (387 aa) fasta scores: E(): 5.6e-74, 48.38% id in 372 aa, and to Staphylococcus xylosus acetoin utilization protein AcuC SW:ACUC_STAXY (Q56195) (385 aa) fasta scores: E(): 2.2e-113, 68.05% id in 385 aa; histone deacetylase 1892036..1893205 Staphylococcus aureus subsp. aureus MRSA252 2861604 YP_041200.1 CDS ccpA NC_002952.2 1893303 1894292 R Similar to Bacillus subtilis catabolite control protein A CcpA SW:CCPA_BACSU (P25144) (334 aa) fasta scores: E(): 1.7e-56, 53.93% id in 330 aa, and to Staphylococcus xylosus probable catabolite control protein A CcpA SW:CCPA_STAXY (Q56194) (329 aa) fasta scores: E(): 4e-92, 80.85% id in 329 aa; catabolite control protein A complement(1893303..1894292) Staphylococcus aureus subsp. aureus MRSA252 2861352 YP_041201.1 CDS SAR1815 NC_002952.2 1894832 1895923 R catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate; bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase complement(1894832..1895923) Staphylococcus aureus subsp. aureus MRSA252 2861605 YP_041202.1 CDS SAR1816 NC_002952.2 1896617 1897807 R No significant database matches. CDS contains an imperfect 54 amino repeat region, residues 99 to 206; hypothetical protein complement(1896617..1897807) Staphylococcus aureus subsp. aureus MRSA252 2861606 YP_041203.1 CDS SAR1817 NC_002952.2 1897881 1898372 R Similar to Bacillus subtilis hypothetical protein YtxG SW:YTXG_BACSU (P40779) (143 aa) fasta scores: E(): 2.7e-17, 48.148% id in 135 aa, and to Bacillus halodurans general stress protein BH3245 TR:Q9K7W3 (EMBL:AP001518) (148 aa) fasta scores: E(): 7.3e-15, 42.222% id in 135 aa; hypothetical protein complement(1897881..1898372) Staphylococcus aureus subsp. aureus MRSA252 2861607 YP_041204.1 CDS murC NC_002952.2 1898446 1899759 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(1898446..1899759) Staphylococcus aureus subsp. aureus MRSA252 2861321 YP_041205.1 CDS SAR1819 NC_002952.2 1899783 1903607 R C-terminus is similar to the C-terminal regions of Bacillus subtilis stage III sporulation protein E SpoIIIE SW:SP3E_BACSU (P21458) (787 aa) fasta scores: E(): 8.8e-56, 47.784% id in 519 aa, and Bacillus halodurans DNA translocase BH3250 TR:Q9K7V9 (EMBL:AP001518) (960 aa) fasta scores: E(): 5.4e-80, 42.638% id in 849 aa; FtsK/SpoIIIE family protein complement(1899783..1903607) Staphylococcus aureus subsp. aureus MRSA252 2861608 YP_041206.1 CDS SAR1820 NC_002952.2 1903628 1904266 R C-terminus is similar to the N-terminal region of Bacillus subtilis phenylalanyl-tRNA synthetase beta chain hypothetical protein PheT SW:SYFB_BACSU (P17922) (804 aa) fasta scores: E(): 4.8e-12, 41.985% id in 131 aa, and to full length Bacillus subtilis YtpR TR:O34943 (EMBL:AF008220) (201 aa) fasta scores: E(): 1.3e-33, 57.346% id in 211 aa. CDS contain additional amino acids, residues 51 to 64, compared to orthologues; the effect on the function of protein is not known; hypothetical protein complement(1903628..1904266) Staphylococcus aureus subsp. aureus MRSA252 2861609 YP_041207.1 CDS SAR1821 NC_002952.2 1904295 1905152 R Similar to Bacillus subtilis hypothetical protein YtpQ TR:O34496 (EMBL:AF008220) (269 aa) fasta scores: E(): 3e-50, 52.239% id in 268 aa, and to Bacillus halodurans hypothetical protein BH3252 TR:Q9K7V7 (EMBL:AP001518) (265 aa) fasta scores: E(): 3.8e-41, 44.528% id in 265 aa; hypothetical protein complement(1904295..1905152) Staphylococcus aureus subsp. aureus MRSA252 2861610 YP_041208.1 CDS SAR1822 NC_002952.2 1905252 1905563 R Similar to Schizosaccharomyces pombe thioredoxin II TRX2 SW:TRX2_SCHPO (O14463) (102 aa) fasta scores: E(): 2.1e-07, 31.579% id in 95 aa, and to Bacillus subtilis thioredoxin YtpP TR:O34357 (EMBL:AF008220) (107 aa) fasta scores: E(): 1.3e-18, 51.000% id in 100 aa; thioredoxin complement(1905252..1905563) Staphylococcus aureus subsp. aureus MRSA252 2861611 YP_041209.1 CDS SAR1823 NC_002952.2 1905628 1906704 R Similar to Lactococcus lactis glutamyl-aminopeptidase PepA SW:PEPA_LACLC (Q48677) (355 aa) fasta scores: E(): 2.2e-51, 41.690% id in 355 aa, and to Bacillus subtilis hypothetical protein YtoP TR:O34924 (EMBL:AF008220) (357 aa) fasta scores: E(): 8e-61, 44.957% id in 347 aa; aminopeptidase complement(1905628..1906704) Staphylococcus aureus subsp. aureus MRSA252 2861612 YP_041210.1 CDS SAR1824 NC_002952.2 1906791 1907102 D Similar to Bacillus subtilis hypothetical protein YtzB TR:O32065 (EMBL:Z99119) (105 aa) fasta scores: E(): 0.032, 25.243% id in 103 aa, and to Bacillus halodurans hypothetical protein BH3258 TR:Q9K7V1 (EMBL:AP001518) (102 aa) fasta scores: E(): 0.078, 25.532% id in 94 aa; hypothetical protein 1906791..1907102 Staphylococcus aureus subsp. aureus MRSA252 2861613 YP_041211.1 CDS SAR1825 NC_002952.2 1907226 1908068 R Similar to Bacillus halodurans hypothetical protein BH3260 TR:Q9K7U9 (EMBL:AP001518) (284 aa) fasta scores: E(): 1.3e-56, 51.481% id in 270 aa, and to Bacillus subtilis hypothetical protein YtnP TR:O34760 (EMBL:AF008220) (256 aa) fasta scores: E(): 7.7e-50, 51.181% id in 254 aa; metallo-beta-lactamase superfamily protein complement(1907226..1908068) Staphylococcus aureus subsp. aureus MRSA252 2861614 YP_041212.1 CDS SAR1826 NC_002952.2 1908514 1909329 R Highly similar to Staphylococcus aureus potential ATP-binding protein SW:ATBP_STAAU (P18179) (271 aa) fasta scores: E(): 5.9e-103, 99.631% id in 271 aa; ATP-binding protein complement(1908514..1909329) Staphylococcus aureus subsp. aureus MRSA252 2861615 YP_041213.1 CDS SAR1827 NC_002952.2 1909322 1910764 R Identical to Staphylococcus aureus transposase for transposon Tn552 SW:TRA3_STAAU (P18416) (480 aa) fasta scores: E(): 1.2e-189, 100.000% id in 480 aa. Similar to Rhizobium loti transposase MLR6273 TR:BAB52595 (EMBL:AP003008) (535 aa) fasta scores: E(): 3.6e-12, 24.486% id in 486 aa; transposase complement(1909322..1910764) Staphylococcus aureus subsp. aureus MRSA252 2861616 YP_041214.1 CDS tnpR NC_002952.2 1910736 1911329 R Similar to Staphylococcus aureus transposon Tn552 resolvase TnpR SW:BINL_STAAU (P18358) (197 aa) fasta scores: E(): 2.1e-72, 98.477% id in 197 aa, and to Lactococcus lactis resolvase TnpR TR:Q9R778 (EMBL:X92946) (183 aa) fasta scores: E(): 2.5e-55, 79.781% id in 183 aa; resolvase complement(1910736..1911329) Staphylococcus aureus subsp. aureus MRSA252 2859543 YP_041215.1 CDS blaI NC_002952.2 1911593 1911973 R Identical to Staphylococcus aureus penicillinase repressor BlaI SW:BLAI_STAAU (P18415) (126 aa) fasta scores: E(): 1.6e-40, 100.000% id in 126 aa. Similar to Bacillus licheniformis penicillinase repressor blaI SW:BLAI_BACLI (P06555) (128 aa) fasta scores: E(): 1.1e-11, 41.026% id in 117 aa; penicillinase repressor complement(1911593..1911973) Staphylococcus aureus subsp. aureus MRSA252 2858973 YP_041216.1 CDS blaR1 NC_002952.2 1911963 1913720 R Highly similar to Staphylococcus aureus beta-lactamase regulatory protein BlaR1 SW:BLAR_STAAU (P18357) (585 aa) fasta scores: E(): 0, 99.145% id in 585 aa. Similar to Bacillus licheniformis regulatory protein BlaR1 SW:BLAR_BACLI (P12287) (601 aa) fasta scores: E(): 4.7e-45, 27.703% id in 592 aa; beta-lactamase regulatory protein complement(1911963..1913720) Staphylococcus aureus subsp. aureus MRSA252 2858974 YP_041217.1 CDS blaZ NC_002952.2 1913827 1914672 D Similar to Staphylococcus aureus beta-lactamase precursor BlaZ SW:BLAC_STAAU (P00807) (281 aa) fasta scores: E(): 2.6e-94, 99.644% id in 281 aa, and to Bacillus licheniformis beta-lactamase precursor PenP SW:BLAC_BACLI (P00808) (307 aa) fasta scores: E(): 8.9e-36, 40.956% id in 293 aa; beta-lactamase precursor 1913827..1914672 Staphylococcus aureus subsp. aureus MRSA252 2859819 YP_041218.1 CDS SAR1832 NC_002952.2 1914968 1915084 D No significant database matches. Doubtful CDS; hypothetical protein 1914968..1915084 Staphylococcus aureus subsp. aureus MRSA252 2861617 YP_041219.1 CDS trmB NC_002952.2 1915146 1915790 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(1915146..1915790) Staphylococcus aureus subsp. aureus MRSA252 2861618 YP_041220.1 CDS SAR1834 NC_002952.2 1915805 1916596 R Similar to Bacillus halodurans hypothetical protein BH3263 TR:Q9K7U6 (EMBL:AP001518) (261 aa) fasta scores: E(): 2e-50, 47.308% id in 260 aa, and to Bacillus subtilis hypothetical protein YtmP TR:O34935 (EMBL:AF008220) (269 aa) fasta scores: E(): 9.4e-48, 46.693% id in 257 aa; hypothetical protein complement(1915805..1916596) Staphylococcus aureus subsp. aureus MRSA252 2860334 YP_041221.1 CDS dat NC_002952.2 1917147 1917995 R Similar to Listeria monocytogenes D-alanine aminotransferase Dat SW:DAAA_LISMO (O85046) (289 aa) fasta scores: E(): 1.8e-48, 51.986% id in 277 aa, and to Staphylococcus haemolyticus D-alanine aminotransferase Dat SW:DAAA_STAHA (P54694) (282 aa) fasta scores: E(): 2e-88, 80.071% id in 281 aa; D-alanine aminotransferase complement(1917147..1917995) Staphylococcus aureus subsp. aureus MRSA252 2859265 YP_041222.1 CDS SAR1836 NC_002952.2 1917999 1919408 R divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV complement(1917999..1919408) Staphylococcus aureus subsp. aureus MRSA252 2860335 YP_041223.1 CDS SAR1837 NC_002952.2 1919614 1920036 R Similar to the N-terminal region of Neisseria meningitidis hypothetical protein NMA2141 TR:Q9JST6 (EMBL:AL162758) (239 aa) fasta scores: E(): 1.8, 23.387% id in 124 aa. N-terminus is similar to the N-terminal region of Streptococcus pyogenes hypothetical protein SPY0588 TR:Q9A0W2 (EMBL:AE006514) (142 aa) fasta scores: E(): 2, 28.302% id in 106 aa; hypothetical protein complement(1919614..1920036) Staphylococcus aureus subsp. aureus MRSA252 2860336 YP_041224.1 CDS SAR1838 NC_002952.2 1920053 1920748 R Similar to Escherichia coli ribosomal small subunit pseudouridine synthase A RsuA SW:RSUA_ECOLI (P33918) (231 aa) fasta scores: E(): 2.1e-23, 37.004% id in 227 aa, and to Bacillus halodurans 16S pseudouridylate synthase BH3273 TR:Q9K7T6 (EMBL:AP001518) (238 aa) fasta scores: E(): 6.2e-41, 56.332% id in 229 aa; RNA pseudouridine synthase complement(1920053..1920748) Staphylococcus aureus subsp. aureus MRSA252 2860337 YP_041225.1 CDS SAR1839 NC_002952.2 1920745 1922406 R Similar to Bacillus subtilis hypothetical protein YtgP TR:O34674 (EMBL:AF008220) (544 aa) fasta scores: E(): 7.6e-68, 36.015% id in 547 aa, and to Bacillus subtilis stage V sporulation protein B SpoVB SW:SP5B_BACSU (Q00758) (518 aa) fasta scores: E(): 6.4e-05, 21.124% id in 516 aa; polysaccharide biosynthesis protein complement(1920745..1922406) Staphylococcus aureus subsp. aureus MRSA252 2860338 YP_041226.1 CDS SAR1840 NC_002952.2 1922810 1924078 D Similar to Bacillus subtilis hypothetical protein YtfP TR:O30505 (EMBL:AF008220) (405 aa) fasta scores: E(): 3.1e-85, 58.231% id in 407 aa, and to Bacillus halodurans hypothetical protein BH3279 TR:Q9K7T0 (EMBL:AP001518) (422 aa) fasta scores: E(): 1e-83, 54.893% id in 419 aa; hypothetical protein 1922810..1924078 Staphylococcus aureus subsp. aureus MRSA252 2860339 YP_041227.1 CDS sasC NC_002952.2 1924195 1930764 R Similar to Staphylococcus aureus hypothetical protein affecting the methicillin resistance Mrp TR:Q9RL69 (EMBL:Y09927) (2478 aa) fasta scores: E(): 2e-139, 32.553% id in 2178 aa, and to Abiotrophia defectiva extracellular matrix binding protein Emb TR:O85472 (EMBL:AF067776) (2055 aa) fasta scores: E(): 1.8e-62, 25.954% id in 2096 aa. Probable LPXTG-sorted surface protein; surface anchored protein complement(1924195..1930764) Staphylococcus aureus subsp. aureus MRSA252 2859120 YP_041228.1 CDS SAR1842 NC_002952.2 1931088 1931399 R Similar to Lactococcus lactis hypothetical protein YhjC TR:Q9CHE7 (EMBL:AE006312) (102 aa) fasta scores: E(): 6.9e-08, 38.710% id in 93 aa, and to Neisseria meningitidis hypothetical protein NMB1884 TR:Q9JXU1 (EMBL:AE002538) (107 aa) fasta scores: E(): 1.8e-07, 38.889% id in 90 aa; hypothetical protein complement(1931088..1931399) Staphylococcus aureus subsp. aureus MRSA252 2860340 YP_041229.1 CDS leuS NC_002952.2 1931421 1933835 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(1931421..1933835) Staphylococcus aureus subsp. aureus MRSA252 2859801 YP_041230.1 CDS SAR1844 NC_002952.2 1934127 1935308 R Similar to Bacillus subtilis hypothetical protein YttB TR:O34546 (EMBL:AF008220) (397 aa) fasta scores: E(): 5.6e-71, 51.918% id in 391 aa, and to Bacillus halodurans multidrug resistance protein BH3282 TR:Q9K7S7 (EMBL:AP001518) (401 aa) fasta scores: E(): 2.1e-68, 51.459% id in 377 aa; hypothetical protein complement(1934127..1935308) Staphylococcus aureus subsp. aureus MRSA252 2860341 YP_041231.1 CDS SAR1845 NC_002952.2 1935419 1936372 D Similar to Bacillus subtilis hypothetical protein YtqA TR:O35008 (EMBL:AF008220) (322 aa) fasta scores: E(): 2.5e-94, 75.490% id in 306 aa, and to Bacillus halodurans hypothetical protein BH3284 TR:Q9K7S5 (EMBL:AP001518) (325 aa) fasta scores: E(): 7.4e-90, 69.805% id in 308 aa; hypothetical protein 1935419..1936372 Staphylococcus aureus subsp. aureus MRSA252 2860342 YP_041232.1 CDS SAR1846 NC_002952.2 1936369 1936932 D Similar to Bacillus halodurans hypothetical protein BH3285 TR:Q9K7S4 (EMBL:AP001518) (190 aa) fasta scores: E(): 2.1e-31, 52.381% id in 189 aa, and to Bacillus subtilis hypothetical protein YtqB TR:O34614 (EMBL:AF008220) (194 aa) fasta scores: E(): 1.2e-30, 51.596% id in 188 aa; hypothetical protein 1936369..1936932 Staphylococcus aureus subsp. aureus MRSA252 2860343 YP_041233.1 CDS rot NC_002952.2 1937051 1937551 R Previously sequenced as Staphylococcus aureus repressor of toxins Rot TR:Q9RFJ6 (EMBL:AF189239) (166 aa) fasta scores: E(): 5.7e-60, 97.590% id in 166 aa. Similar to Staphylococcus aureus SarR TR:Q9F0R1 (EMBL:AF207701) (115 aa) fasta scores: E(): 0.0043, 28.814% id in 118 aa. Probable alternative translational start sites; repressor of toxins complement(1937051..1937551) Staphylococcus aureus subsp. aureus MRSA252 2860897 YP_041234.1 CDS SAR1848 NC_002952.2 1938025 1938852 R Similar to Bacillus halodurans lysophospholipase BH3288 TR:Q9K7S1 (EMBL:AP001518) (260 aa) fasta scores: E(): 1e-28, 34.091% id in 264 aa, and to Bacillus subtilis probable lysophospholipase YtpA TR:O34705 (EMBL:AF008220) (259 aa) fasta scores: E(): 2e-27, 32.184% id in 261 aa; hypothetical protein complement(1938025..1938852) Staphylococcus aureus subsp. aureus MRSA252 2860344 YP_041235.1 CDS SAR1849 NC_002952.2 1939086 1940087 D Similar to Bacillus halodurans proline oxidase BH2740 TR:Q9K9A9 (EMBL:AP001516) (306 aa) fasta scores: E(): 2e-44, 45.638% id in 298 aa, and to Bacillus subtilis hypothetical protein YusM TR:O32179 (EMBL:Z99120) (302 aa) fasta scores: E(): 1.1e-40, 42.244% id in 303 aa; proline dehydrogenase 1939086..1940087 Staphylococcus aureus subsp. aureus MRSA252 2860345 YP_041236.1 CDS ribH NC_002952.2 1940209 1940673 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(1940209..1940673) Staphylococcus aureus subsp. aureus MRSA252 2859270 YP_041237.1 CDS ribA NC_002952.2 1940686 1941867 R Similar to Actinobacillus pleuropneumoniae riboflavin biosynthesis protein RibA [includes: GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase] RibA SW:GCH2_ACTPL (P50855) (401 aa) fasta scores: E(): 1.8e-77, 51.777% id in 394 aa, and to Bacillus halodurans GTP cyclohydrolase II/ 3, 4-dihydroxy-2-butanone 4-phosphate synthase BH1556 TR:Q9KCL5 (EMBL:AP001512) (404 aa) fasta scores: E(): 3.4e-79, 52.284% id in 394 aa; riboflavin biosynthesis protein complement(1940686..1941867) Staphylococcus aureus subsp. aureus MRSA252 2859308 YP_041238.1 CDS ribE NC_002952.2 1941878 1942510 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(1941878..1942510) Staphylococcus aureus subsp. aureus MRSA252 2859269 YP_041239.1 CDS ribD NC_002952.2 1942517 1943560 R Similar to Escherichia coli riboflavin biosynthesis protein RibD [includes: diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5- phosphoribosylamino)uracil reductase] RibD SW:RIBD_ECOLI (P25539) (367 aa) fasta scores: E(): 1.4e-25, 34.444% id in 360 aa, and to Aquifex aeolicus riboflavin biosynthesis protein ribd [includes: diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5- phosphoribosylamino)uracil reductase] AQ_138 SW:RIBD_AQUAE (O66534) (356 aa) fasta scores: E(): 5.3e-41, 40.323% id in 310 aa; bifunctional riboflavin biosynthesis protein complement(1942517..1943560) Staphylococcus aureus subsp. aureus MRSA252 2859309 YP_041240.1 CDS SAR1854 NC_002952.2 1944041 1945543 R Similar to Rhizobium loti hypothetical protein MLR5217 TR:BAB51703 (EMBL:AP003006) (486 aa) fasta scores: E(): 9.5e-05, 19.141% id in 512 aa, and to Rhizobium loti hypothetical protein MLL4514 TR:BAB51151 (EMBL:AP003004) (450 aa) fasta scores: E(): 0.0097, 19.798% id in 495 aa; hypothetical protein complement(1944041..1945543) Staphylococcus aureus subsp. aureus MRSA252 2860346 YP_041241.1 CDS arsR2 NC_002952.2 1946186 1946500 D Similar to Staphylococcus aureus arsenical resistance operon repressor ArsR SW:ARSR_STAAU (P30338) (104 aa) fasta scores: E(): 5.4e-32, 75.962% id in 104 aa, and to Bacillus subtilis arsenical resistance operon repressor ArsR SW:ARSR_BACSU (P45949) (105 aa) fasta scores: E(): 2.1e-06, 38.542% id in 96 aa. Similar to SAR0690, 75.000% identity (75.000% ungapped) in 104 aa overlap; arsenical resistance operon repressor 2 1946186..1946500 Staphylococcus aureus subsp. aureus MRSA252 2859868 YP_041242.1 CDS arsB2 NC_002952.2 1946500 1947792 D Similar to Staphylococcus aureus arsenical pump membrane protein ArsB SW:ARSB_STAAU (P30329) (429 aa) fasta scores: E(): 1.1e-119, 79.953% id in 429 aa, and to Escherichia coli arsenical pump membrane protein ArsB SW:ARSB_ECOLI (P37310) (429 aa) fasta scores: E(): 1.1e-82, 55.556% id in 423 aa. Similar to SAR0691, 79.254% identity (79.254% ungapped) in 429 aa overlap; arsenical pump membrane protein 2 1946500..1947792 Staphylococcus aureus subsp. aureus MRSA252 2859865 YP_041243.1 CDS SAR1857 NC_002952.2 1947879 1948733 R Possible gene remnant. C-terminus is similar to C-terminal regions of Staphylococcus aureus bifunctional autolysin precursor [includes: N-acetylmuramoyl-L-alanine amidase; mannosyl-glycoprotein endo-beta-N-acetylglucosamidase] Atl SW:ATL_STAAU (P52081) (1256 aa) fasta scores: E(): 7.5e-30, 42.857% id in 245 aa, and to Staphylococcus saprophyticus surface protein Aas TR:O86919 (EMBL:AJ000007) (1463 aa) fasta scores: E(): 8e-34, 48.163% id in 245 aa; hypothetical protein complement(1947879..1948733) Staphylococcus aureus subsp. aureus MRSA252 2860347 YP_041244.1 CDS SAR1858 NC_002952.2 1949009 1949233 R Poor database matches. Similar to C-terminal region of Arabidopsis thaliana floral homeotic protein PI SW:PIST_ARATH (P48007) (208 aa) fasta scores: E(): 3.8, 30.556% id in 72 aa; hypothetical protein complement(1949009..1949233) Staphylococcus aureus subsp. aureus MRSA252 2860348 YP_041245.1 CDS SAR1859 NC_002952.2 1949432 1949902 D Poor database matches. Similar to Clostridium botulinum phage 1C hypothetical protein Orf22 TR:Q38195 (EMBL:X72793) (179 aa) fasta scores: E(): 0.00077, 27.389% id in 157 aa, and to Escherichia coli probable RNA polymerase sigma factor FecI SW:FECI_ECOLI (P23484) (173 aa) fasta scores: E(): 0.097, 25.610% id in 164 aa; DNA-binding protein 1949432..1949902 Staphylococcus aureus subsp. aureus MRSA252 2860349 YP_041246.1 CDS SAR1860 NC_002952.2 1950015 1950458 D hypothetical protein 1950015..1950458 Staphylococcus aureus subsp. aureus MRSA252 2860350 YP_041247.1 CDS SAR1861 NC_002952.2 1950445 1950888 R hypothetical protein complement(1950445..1950888) Staphylococcus aureus subsp. aureus MRSA252 2860351 YP_041248.1 CDS SAR1862 NC_002952.2 1951186 1951821 D Poor database matches. Similar to Streptococcus pneumoniae ABC transporter ATP binding domain SP0547 TR:Q9EW58 (EMBL:AJ278419) (203 aa) fasta scores: E(): 2.2e-07, 27.778% id in 198 aa. Similar to SAR1863, 52.000% identity (52.000% ungapped) in 200 aa overlap; CAAX amino terminal protease 1951186..1951821 Staphylococcus aureus subsp. aureus MRSA252 2860352 YP_041249.1 CDS SAR1863 NC_002952.2 1951988 1952608 D Poor database matches. Similar to Streptococcus pneumoniae ABC transporter ATP binding domain SP0547 TR:Q9EW58 (EMBL:AJ278419) (203 aa) fasta scores: E(): 3.8e-07, 23.858% id in 197 aa. Similar to SAR1862, 52.000% identity (52.000% ungapped) in 200 aa overlap; hypothetical protein 1951988..1952608 Staphylococcus aureus subsp. aureus MRSA252 2860353 YP_041250.1 CDS SAR1864 NC_002952.2 1953066 1953779 R similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; translaldolase complement(1953066..1953779) Staphylococcus aureus subsp. aureus MRSA252 2860354 YP_041251.1 CDS SAR1865 NC_002952.2 1954038 1954340 D Poor database matches. Similar to the C-terminal region of Escherichia coli hypothetical protein EscT TR:Q9AJ27 (EMBL:AF200363) (258 aa) fasta scores: E(): 2.3, 33.333% id in 93 aa; hypothetical protein 1954038..1954340 Staphylococcus aureus subsp. aureus MRSA252 2860355 YP_041252.1 CDS SAR1866 NC_002952.2 1954517 1954960 D may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1954517..1954960 Staphylococcus aureus subsp. aureus MRSA252 2860356 YP_041253.1 CDS SAR1867 NC_002952.2 1954957 1955310 D Similar to Escherichia coli camphor resistance and chromosome condensation protein CrcB SW:CRCB_ECOLI (P37002) (127 aa) fasta scores: E(): 6.9e-06, 34.959% id in 123 aa, and to Bacillus halodurans protein CrcB homologue 1 BH2986 TR:Q9K8M0 (EMBL:AP001517) (127 aa) fasta scores: E(): 2.6e-06, 36.800% id in 125 aa; CrcB-like protein 1954957..1955310 Staphylococcus aureus subsp. aureus MRSA252 2860357 YP_041254.1 CDS SAR1868 NC_002952.2 1955560 1956393 R Similar to Bacillus subtilis morphine dehydrogenase YtbE TR:O34678 (EMBL:AF008220) (280 aa) fasta scores: E(): 8.8e-57, 54.779% id in 272 aa, and to Bacillus subtilis hypothetical protein YvgN TR:O32210 (EMBL:Z99121) (276 aa) fasta scores: E(): 3.7e-56, 56.554% id in 267 aa; aldo/keto reductase complement(1955560..1956393) Staphylococcus aureus subsp. aureus MRSA252 2860358 YP_041255.1 CDS SAR1869 NC_002952.2 1956605 1957516 R Poor database matches. N-terminus is similar to N-terminal region of Physarum polycephalum plasmodial specific LAV1-2 protein SW:LAV1_PHYPO (P14725) (355 aa) fasta scores: E(): 3.2, 25.82% id in 213 aa; hypothetical protein complement(1956605..1957516) Staphylococcus aureus subsp. aureus MRSA252 2860359 YP_041256.1 CDS SAR1870 NC_002952.2 1957638 1958831 R methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase complement(1957638..1958831) Staphylococcus aureus subsp. aureus MRSA252 2860360 YP_041257.1 CDS pckA NC_002952.2 1959203 1960795 D PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 1959203..1960795 Staphylococcus aureus subsp. aureus MRSA252 2861481 YP_041258.1 CDS SAR1873 NC_002952.2 1961088 1961858 R Similar to Bacillus subtilis peptidase YtmA TR:O34493 (EMBL:AF008220) (257 aa) fasta scores: E(): 2.9e-28, 39.74% id in 239 aa, and to Bacillus halodurans hypothetical protein BH3306 TR:Q9K7Q5 (EMBL:AP001518) (265 aa) fasta scores: E(): 1.4e-23, 37.54% id in 253 aa; hypothetical protein complement(1961088..1961858) Staphylococcus aureus subsp. aureus MRSA252 2860361 YP_041259.1 CDS SAR1874 NC_002952.2 1961839 1962318 R Similar to Bacillus subtilis hypothetical protein YtkD TR:O35013 (EMBL:AF008220) (158 aa) fasta scores: E(): 1.1e-15, 37.34% id in 158 aa, and to Bacillus halodurans hypothetical protein BH3308 TR:Q9K7Q3 (EMBL:AP001518) (157 aa) fasta scores: E(): 2.3e-12, 36% id in 150 aa; hypothetical protein complement(1961839..1962318) Staphylococcus aureus subsp. aureus MRSA252 2860542 YP_041260.1 CDS SAR1875 NC_002952.2 1962378 1962635 D Similar to Bacillus subtilis hypothetical protein YtjA SW:YTJA_BACSU (O34601) (75 aa) fasta scores: E(): 2.7e-20, 70.27% id in 74 aa, and to Bacillus halodurans hypothetical protein BH2828 SW:YS28_BACHD (Q9K921) (75 aa) fasta scores: E(): 1.1e-18, 64.86% id in 74 aa; hypothetical protein 1962378..1962635 Staphylococcus aureus subsp. aureus MRSA252 2860543 YP_041261.1 CDS SAR1876 NC_002952.2 1962632 1963633 R Similar to Amycolatopsis sp N-acylamino acid racemase AaaR TR:Q44244 (EMBL:D30738) (368 aa) fasta scores: E(): 1.8e-09, 24.92% id in 341 aa, and to Thermoplasma acidophilum probable N-acylamino acid racemase TA0249 TR:Q9HLH9 (EMBL:AL445063) (361 aa) fasta scores: E(): 1.4e-10, 25.14% id in 342 aa; hypothetical protein complement(1962632..1963633) Staphylococcus aureus subsp. aureus MRSA252 2860544 YP_041262.1 CDS SAR1877 NC_002952.2 1963638 1965116 R Similar to Bacillus subtilis O-succinylbenzoic CoA synthase MenE TR:O34837 (EMBL:AF008220) (486 aa) fasta scores: E(): 9.5e-47, 32.86% id in 496 aa, and to Lactococcus lactis O-succinylbenzoic acid-CoA ligase MenE TR:Q9CHK3 (EMBL:AE006306) (420 aa) fasta scores: E(): 4.9e-34, 35.26% id in 448 aa; AMP-binding protein complement(1963638..1965116) Staphylococcus aureus subsp. aureus MRSA252 2860545 YP_041263.1 CDS SAR1878 NC_002952.2 1965275 1965757 R lipoprotein complement(1965275..1965757) Staphylococcus aureus subsp. aureus MRSA252 2860546 YP_041264.1 CDS SAR1879 NC_002952.2 1966128 1966682 D No significant database matches. Possible alternative translational start sites; hypothetical protein 1966128..1966682 Staphylococcus aureus subsp. aureus MRSA252 2860547 YP_041265.1 CDS SAR1880 NC_002952.2 1966763 1967758 D Internal region is similar to N-terminus of Bacillus halodurans hypothetical protein BH3064 TR:Q9K8E2 (EMBL:AP001517) (215 aa) fasta scores: E(): 7.7e-10, 37.58% id in 141 aa; hypothetical protein 1966763..1967758 Staphylococcus aureus subsp. aureus MRSA252 2860548 YP_041266.1 CDS SAR1881 NC_002952.2 1967834 1968460 D lipoprotein 1967834..1968460 Staphylococcus aureus subsp. aureus MRSA252 2860549 YP_041267.1 CDS SAR1882 NC_002952.2 1968501 1968845 D Poor database matches. Similar to Chrysodidymus synuroideus ribosomal protein S10 Rps10 TR:Q9MGA1 (EMBL:AF222718) (103 aa) fasta scores: E(): 9.2, 26.66% id in 90 aa; hypothetical protein 1968501..1968845 Staphylococcus aureus subsp. aureus MRSA252 2860550 YP_041268.1 CDS SAR1883 NC_002952.2 1968943 1969515 D Poor database matches. Similar to N-terminal region of Mycoplasma pulmonis hypothetical protein MYPU_3700 TR:CAC13543 (EMBL:AL445564) (292 aa) fasta scores: E(): 3.5e-08, 37.25% id in 153 aa. Possible gene remnant; hypothetical protein 1968943..1969515 Staphylococcus aureus subsp. aureus MRSA252 2860551 YP_041269.1 CDS SAR1884 NC_002952.2 1969664 1971031 R C-terminus is similar to an internal region of Bacillus anthracis virulence plasmid pX01 hypothetical protein pX01-90 TR:Q9X360 (EMBL:AF065404) (652 aa) fasta scores: E(): 0.017, 29.9% id in 214 aa; hypothetical protein complement(1969664..1971031) Staphylococcus aureus subsp. aureus MRSA252 2860552 YP_041270.1 CDS SAR1885 NC_002952.2 1971031 1971600 R Poor database matches. Similar to N-terminal region of Borrelia burgdorferi hypothetical protein BBB26 TR:O50997 (EMBL:AE000792) (231 aa) fasta scores: E(): 1.4e-05, 31.05% id in 161 aa. N-terminus is similar to the N-terminal region of Bacillus subtilis phage-like element PBSX protein XkdA SW:XKDA_BACSU (P39780) (198 aa) fasta scores: E(): 0.41, 25.64% id in 117 aa; hypothetical protein complement(1971031..1971600) Staphylococcus aureus subsp. aureus MRSA252 2860553 YP_041271.1 CDS SAR1886 NC_002952.2 1971793 1972239 R No significant database matches. Similar to SAR1889, 65.541% identity (65.986% ungapped) in 148 aa overlap, SAR1894, 59.864% identity (60.274% ungapped) in 147 aa overlap, an to SAR1890, 56.081% identity (56.463% ungapped) in 148 aa overlap. C-terminal region is similar to SAR1891, 68.224% identity (68.868% ungapped) in 107 aa overlap; hypothetical protein complement(1971793..1972239) Staphylococcus aureus subsp. aureus MRSA252 2860554 YP_041272.1 CDS SAR1889 NC_002952.2 1973184 1973630 R No significant database matches. Similar to SAR1886, 65.541% identity (65.986% ungapped) in 148 aa overlap, SAR1890, 62.838% identity (62.838% ungapped) in 148 aa overlap, SAR1894, 55.405% identity (55.405% ungapped) in 148 aa overlap, and to SAR1891, 62.264% identity (62.264% ungapped) in 106 aa overlap; hypothetical protein complement(1973184..1973630) Staphylococcus aureus subsp. aureus MRSA252 2859311 YP_041273.1 CDS SAR1890 NC_002952.2 1973627 1974073 R No significant database matches. Similar to SAR1889, 62.838% identity (62.838% ungapped) in 148 aa overlap, SAR1886, 56.081% identity (56.463% ungapped) in 148 aa overlap, SAR1894, 55.034% identity (55.405% ungapped) in 149 aa overlap, and to SAR1891, 61.321% identity (61.321% ungapped) in 106 aa overlap; hypothetical protein complement(1973627..1974073) Staphylococcus aureus subsp. aureus MRSA252 2859312 YP_041274.1 CDS hysA1 NC_002952.2 1975037 1977457 D Similar to Staphylococcus aureus hyaluronate lyase precursor HysA SW:HYSA_STAAU (Q59801) (807 aa) fasta scores: E(): 0, 75.8% id in 810 aa, and to Streptococcus pneumoniae hyaluronate lyase precursor SP0314 SW:HYSA_STRPN (Q54873) (949 aa) fasta scores: E(): 6.5e-74, 35.34% id in 795 aa. Similar to SAR2292, 74.969% identity (75.716% ungapped) in 811 aa overlap; hyaluronate lyase precursor 1 1975037..1977457 Staphylococcus aureus subsp. aureus MRSA252 2859653 YP_041275.1 CDS SAR1893 NC_002952.2 1977583 1977960 R No significant database matches. Possible alternative translational start sites; hypothetical protein complement(1977583..1977960) Staphylococcus aureus subsp. aureus MRSA252 2859314 YP_041276.1 CDS SAR1894 NC_002952.2 1978170 1978619 R No significant database matches. Similar to SAR1891, 90.566% identity (90.566% ungapped) in 106 aa overlap, SAR1886, 59.864% identity (60.274% ungapped) in 147 aa overlap, SAR1889, 55.405% identity (55.405% ungapped) in 148 aa overlap, and to SAR1890, 55.034% identity (55.405% ungapped) in 149 aa overlap. Similar to SAR1891, 90.566% identity (90.566% ungapped) in 106 aa overlap, SAR1886, 59.864% identity (60.274% ungapped) in 147 aa overlap, SAR1889, 55.405% identity (55.405% ungapped) in 148 aa overlap, and to SAR1890, 55.034% identity (55.405% ungapped) in 149 aa overlap; hypothetical protein complement(1978170..1978619) Staphylococcus aureus subsp. aureus MRSA252 2859315 YP_041277.1 CDS SAR1895 NC_002952.2 1978662 1980272 D Poor database matches. Similar to internal region of Clostridium botulinum botulinum neurotoxin type C1 precursor SW:BXC1_CLOBO (P18640) (1290 aa) fasta scores: E(): 0.41, 20.46% id in 557 aa; hypothetical protein 1978662..1980272 Staphylococcus aureus subsp. aureus MRSA252 2859316 YP_041278.1 CDS SAR1896 NC_002952.2 1980287 1980586 D Poor database matches. Similar to internal region of Campylobacter jejuni periplasmic protein CJ0162C TR:Q9PIW5 (EMBL:AL139074) (171 aa) fasta scores: E(): 1, 29.16% id in 96 aa; hypothetical protein 1980287..1980586 Staphylococcus aureus subsp. aureus MRSA252 2859317 YP_041279.1 CDS SAR1897 NC_002952.2 1980848 1982665 R Poor database matches. Similar to N-terminal region of Synechocystis sp hypothetical protein SLR1135 TR:P73259 (EMBL:D90905) (715 aa) fasta scores: E(): 4.7e-05, 24.76% id in 626 aa; hypothetical protein complement(1980848..1982665) Staphylococcus aureus subsp. aureus MRSA252 2859318 YP_041280.1 CDS SAR1898 NC_002952.2 1982702 1983856 R Similar to Streptococcus thermophilus type I restriction modification S-subunit protein TR:O52188 (EMBL:AF027167) (412 aa) fasta scores: E(): 3.1e-26, 32.54% id in 421 aa, and to Lactococcus lactis plasmid pSRQ900 type I restriction modification specificity subunit protein HsdS TR:AAC98712 (EMBL:AF001314) (396 aa) fasta scores: E(): 2.1e-20, 27.88% id in 416 aa; type I restriction modification DNA specificity protein complement(1982702..1983856) Staphylococcus aureus subsp. aureus MRSA252 2859319 YP_041281.1 CDS SAR1899 NC_002952.2 1983849 1985405 R Similar to Escherichia coli type I restriction enzyme EcoR124II M protein HsdM SW:T1M1_ECOLI (P10484) (520 aa) fasta scores: E(): 6.4e-73, 42.18% id in 512 aa, and to Streptococcus thermophilus type IC modification subunit HsdM TR:Q9RNW1 (EMBL:AF177167) (531 aa) fasta scores: E(): 2.4e-84, 49.13% id in 517 aa. Similar to SAR0433, 98.456% identity (98.456% ungapped) in 518 aa overlap; type I restriction modification system modification protein complement(1983849..1985405) Staphylococcus aureus subsp. aureus MRSA252 2859320 YP_041282.1 CDS splE NC_002952.2 1986657 1987373 R Similar to Staphylococcus aureus serine protease SplE TR:Q9KH47 (EMBL:AF271715) (238 aa) fasta scores: E(): 1.9e-85, 97.05% id in 238 aa. Simlar to SAR1905, 63.445% identity (63.445% ungapped) in 238 aa overlap, SAR1900, 64.481% identity (64.835% ungapped) in 183 aa overlap, and to SAR1903, 56.757% identity (56.757% ungapped) in 74 aa overlap; serine protease complement(1986657..1987373) Staphylococcus aureus subsp. aureus MRSA252 2859156 YP_041283.1 CDS SAR1905 NC_002952.2 1988419 1989135 R Similar to Staphylococcus aureus serine protease SplE TR:Q9KH47 (EMBL:AF271715) (238 aa) fasta scores: E(): 3.9e-56, 62.6% id in 238 aa. Similar to SAR1902, 63.445% identity (63.445% ungapped) in 238 aa overlap; serine protease complement(1988419..1989135) Staphylococcus aureus subsp. aureus MRSA252 2859322 YP_041284.1 CDS splC NC_002952.2 1989259 1989978 R Similar to Staphylococcus aureus serine protease SplC TR:Q9KH49 (EMBL:AF271715) (239 aa) fasta scores: E(): 7.6e-83, 94.56% id in 239 aa; serine protease complement(1989259..1989978) Staphylococcus aureus subsp. aureus MRSA252 2859155 YP_041285.1 CDS SAR1908 NC_002952.2 1990279 1990524 D hypothetical protein 1990279..1990524 Staphylococcus aureus subsp. aureus MRSA252 2859324 YP_041286.1 CDS SAR1909 NC_002952.2 1990763 1990894 D hypothetical protein 1990763..1990894 Staphylococcus aureus subsp. aureus MRSA252 2859325 YP_041287.1 CDS SAR1910 NC_002952.2 1990993 1991508 D hypothetical protein 1990993..1991508 Staphylococcus aureus subsp. aureus MRSA252 2859326 YP_041288.1 CDS SAR1911 NC_002952.2 1991755 1993101 D Poor database matches. C-terminus is similar to the C-terminal region of bacteriophage P27 hypothetical protein TR:Q9MC01 (EMBL:AJ249351) (409 aa) fasta scores: E(): 8.6e-21, 32.19% id in 323 aa. Contains coiled-coiled domains, residues 66 to 90, 248 to 278, 299 to 318; hypothetical protein 1991755..1993101 Staphylococcus aureus subsp. aureus MRSA252 2859327 YP_041289.1 CDS SAR1913 NC_002952.2 1993688 1993924 D hypothetical protein 1993688..1993924 Staphylococcus aureus subsp. aureus MRSA252 2859329 YP_041290.1 CDS SAR1916 NC_002952.2 1995296 1996072 R Similar to Staphylococcus aureus extracellular enterotoxin type G precursor Seg TR:O85382 (EMBL:AF064773) (258 aa) fasta scores: E(): 4.5e-101, 97.28% id in 258 aa, and to Staphylococcus aureus enterotoxin type B precursor EntB SW:ETXB_STAAU (P01552) (266 aa) fasta scores: E(): 8.1e-35, 44.65% id in 262 aa; enterotoxin complement(1995296..1996072) Staphylococcus aureus subsp. aureus MRSA252 2859331 YP_041291.1 CDS SAR1917 NC_002952.2 1996356 1997111 R Similar to Staphylococcus aureus enterotoxin SEN TR:Q9EZM4 (EMBL:AF285760) (258 aa) fasta scores: E(): 8.3e-90, 95.21% id in 251 aa, and to Staphylococcus aureus enterotoxin type A precursor EntA SW:ETXA_STAAU (P13163) (257 aa) fasta scores: E(): 8.8e-30, 37.84% id in 251 aa. CDS is truncated at the N-terminus in comparison to orthologues; enterotoxin complement(1996356..1997111) Staphylococcus aureus subsp. aureus MRSA252 2859332 YP_041292.1 CDS SAR1918 NC_002952.2 1997150 1997935 R Similar to Staphylococcus aureus enterotoxin type B precursor EntB SW:ETXB_STAAU (P01552) (266 aa) fasta scores: E(): 4.6e-51, 54.23% id in 260 aa, and to Staphylococcus aureus enterotoxin type C-3 precursor EntC3 SW:ETC3_STAAU (P23313) (266 aa) fasta scores: E(): 1.2e-50, 52.3% id in 260 aa; enterotoxin complement(1997150..1997935) Staphylococcus aureus subsp. aureus MRSA252 2859333 YP_041293.1 CDS SAR1919 NC_002952.2 1998089 1998817 R Similar to Staphylococcus aureus extracellular enterotoxin type I precursor SEI TR:O85383 (EMBL:AF064774) (242 aa) fasta scores: E(): 1.2e-91, 95.86% id in 242 aa, and to Staphylococcus aureus enterotoxin Ent TR:O54476 (EMBL:U93688) (242 aa) fasta scores: E(): 8.6e-64, 67.35% id in 242 aa. Similar to SAR1920, 56.017% identity (57.203% ungapped) in 241 aa overlap; enterotoxin complement(1998089..1998817) Staphylococcus aureus subsp. aureus MRSA252 2859334 YP_041294.1 CDS SAR1920 NC_002952.2 1998852 1999571 R Similar to Staphylococcus aureus enterotoxin SEM TR:Q9EZM7 (EMBL:AF285760) (239 aa) fasta scores: E(): 1.1e-83, 92.05% id in 239 aa, and to Staphylococcus aureus, and extracellular enterotoxin type I precursor SEI TR:O85383 (EMBL:AF064774) (242 aa) fasta scores: E(): 5.6e-49, 57.08% id in 233 aa. Similar to SAR1919, 56.017% identity (57.203% ungapped) in 241 aa overlap; enterotoxin complement(1998852..1999571) Staphylococcus aureus subsp. aureus MRSA252 2859335 YP_041295.1 CDS SAR1921 NC_002952.2 1999853 2000617 R Similar to Staphylococcus aureus enterotoxin SEL TR:Q9EZM8 (EMBL:AF285760) (261 aa) fasta scores: E(): 1.1e-87, 90.55% id in 254 aa, and to Staphylococcus aureus enterotoxin SEK TR:Q9EZM4 (EMBL:AF285760) (258 aa) fasta scores: E(): 1.3e-38, 43.87% id in 253 aa; enterotoxin complement(1999853..2000617) Staphylococcus aureus subsp. aureus MRSA252 2859336 YP_041296.1 CDS SAR1922 NC_002952.2 2002078 2002632 R Similar to Bacillus subtilis hypothetical protein YdeN TR:P96671 (EMBL:AB001488) (190 aa) fasta scores: E(): 3.2e-13, 24.04% id in 183 aa, and to Homo sapiens retinoblastoma-binding protein Bog TR:Q9H1D8 (EMBL:AF039564) (186 aa) fasta scores: E(): 0.00069, 21.22% id in 179 aa; hypothetical protein complement(2002078..2002632) Staphylococcus aureus subsp. aureus MRSA252 2859337 YP_041297.1 CDS hemY NC_002952.2 2002952 2004352 R catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase complement(2002952..2004352) Staphylococcus aureus subsp. aureus MRSA252 2860707 YP_041298.1 CDS hemH NC_002952.2 2004376 2005299 R protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase complement(2004376..2005299) Staphylococcus aureus subsp. aureus MRSA252 2860705 YP_041299.1 CDS hemE NC_002952.2 2005357 2006394 R catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase complement(2005357..2006394) Staphylococcus aureus subsp. aureus MRSA252 2860704 YP_041300.1 CDS trap NC_002952.2 2006656 2007159 D Similar to Staphylococcus aureus signal transduction protein, target of RNAIII-activating protein, TRAP TR:Q9F949 (EMBL:AF202641) (167 aa) fasta scores: E(): 8.2e-60, 88.02% id in 167 aa, and to Bacillus subtilis hypothetical protein YhgC SW:YHGC_BACSU (P38049) (166 aa) fasta scores: E(): 1e-08, 26.54% id in 162 aa; signal transduction protein 2006656..2007159 Staphylococcus aureus subsp. aureus MRSA252 2860395 YP_041301.1 CDS SAR1927 NC_002952.2 2007283 2008506 R Similar to Bacillus subtilis novel ABC transporter EcsB SW:ECSB_BACSU (P55340) (408 aa) fasta scores: E(): 4e-26, 27.97% id in 404 aa, and to Bacillus halodurans ABC transporter BH1192 TR:Q9KDM0 (EMBL:AP001511) (405 aa) fasta scores: E(): 1.7e-21, 24.48% id in 388 aa; transporter protein complement(2007283..2008506) Staphylococcus aureus subsp. aureus MRSA252 2859338 YP_041302.1 CDS SAR1928 NC_002952.2 2008499 2009239 R Similar to Bacillus subtilis ABC-type transporter ATP-binding protein EcsA SW:ECSA_BACSU (P55339) (247 aa) fasta scores: E(): 7.8e-49, 58.82% id in 238 aa, and to Lactococcus lactis ABC transporter ATP binding protein EcsA TR:Q9CE51 (EMBL:AE006429) (256 aa) fasta scores: E(): 7.3e-51, 59.83% id in 239 aa; ABC transporter ATP-binding protein complement(2008499..2009239) Staphylococcus aureus subsp. aureus MRSA252 2859339 YP_041303.1 CDS SAR1929 NC_002952.2 2009373 2009795 D Similar to Schizosaccharomyces pombe hypothetical HIT-family protein SPCC1442.14C TR:O94586 (EMBL:AL031966) (133 aa) fasta scores: E(): 5.7e-13, 37.03% id in 135 aa, and to Bacillus halodurans HIT-like protein involved in cell-cycle regulation BH1189 TR:Q9KDM3 (EMBL:AP001511) (142 aa) fasta scores: E(): 9.8e-25, 53.67% id in 136 aa; HIT-family protein 2009373..2009795 Staphylococcus aureus subsp. aureus MRSA252 2859340 YP_041304.1 CDS SAR1930 NC_002952.2 2009937 2010302 D Poor database matches. Similar to Bacillus halodurans hypothetical protein BH1186 TR:Q9KDM6 (EMBL:AP001511) (114 aa) fasta scores: E(): 0.18, 31.06% id in 103 aa; hypothetical protein 2009937..2010302 Staphylococcus aureus subsp. aureus MRSA252 2859341 YP_041305.1 CDS SAR1930a NC_002952.2 <2010299 2010487 D No significant database matches. Doubtful CDS; hypothetical protein <2010299..2010487 Staphylococcus aureus subsp. aureus MRSA252 2859342 YP_041306.1 CDS SAR1931 NC_002952.2 2011035 2011592 D oor database matches. Similar to Bacillus halodurans hypothetical protein BH1182 TR:Q9KDM9 (EMBL:AP001511) (180 aa) fasta scores: E(): 4.4e-09, 26.85% id in 175 aa; hypothetical protein 2011035..2011592 Staphylococcus aureus subsp. aureus MRSA252 2859343 YP_041307.1 CDS SAR1932 NC_002952.2 2011797 2012759 D Similar to Bacillus subtilis protein export protein PrsA SW:PRSA_BACSU (P24327) (292 aa) fasta scores: E(): 1.8e-10, 35.43% id in 302 aa, and to Bacillus halodurans protein export protein BH1177 TR:Q9KDN4 (EMBL:AP001511) (333 aa) fasta scores: E(): 1.5e-08, 25.24% id in 301 aa; peptidyl-prolyl cis-isomerase 2011797..2012759 Staphylococcus aureus subsp. aureus MRSA252 2859344 YP_041308.1 CDS SAR1933 NC_002952.2 2012880 2013821 R catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates; 3'-5' exoribonuclease YhaM complement(2012880..2013821) Staphylococcus aureus subsp. aureus MRSA252 2859345 YP_041309.1 CDS SAR1934 NC_002952.2 2013818 2016754 R Poor database matches. Similar to Bacillus subtilis hypothetical protein YhaN TR:O08455 (EMBL:Y14078) (963 aa) fasta scores: E(): 2.7e-17, 24.42% id in 991 aa; hypothetical protein complement(2013818..2016754) Staphylococcus aureus subsp. aureus MRSA252 2859346 YP_041310.1 CDS SAR1935 NC_002952.2 2016744 2017940 R Similar to Bacillus subtilis hypothetical protein YhaO TR:O07522 (EMBL:Y14078) (408 aa) fasta scores: E(): 1.1e-38, 34.91% id in 401 aa, and to Methanococcus jannaschii hypothetical protein MJ1323 mj1323 TR:Q58719 (EMBL:U67572) (366 aa) fasta scores: E(): 1e-08, 24.67% id in 385 aa; DNA repair exonuclease complement(2016744..2017940) Staphylococcus aureus subsp. aureus MRSA252 2859347 YP_041311.1 CDS SAR1936 NC_002952.2 2018828 2019172 R Similar to Bacillus subtilis hypothetical protein YheA TR:O07542 (EMBL:Y14080) (117 aa) fasta scores: E(): 1.1e-13, 49.1% id in 112 aa, and to Bacillus firmus hypothetical protein TR:O87558 (EMBL:AF084104) (118 aa) fasta scores: E(): 1e-12, 46.84% id in 111 aa; hypothetical protein complement(2018828..2019172) Staphylococcus aureus subsp. aureus MRSA252 2859348 YP_041312.1 CDS SAR1937 NC_002952.2 2019241 2020365 R Similar to Bacillus firmus hypothetical protein TR:O87557 (EMBL:AF084104) (370 aa) fasta scores: E(): 6.8e-32, 31.09% id in 373 aa, and to Bacillus subtilis hypothetical protein YheB TR:O07543 (EMBL:Y14080) (377 aa) fasta scores: E(): 2.7e-31, 30.35% id in 369 aa; hypothetical protein complement(2019241..2020365) Staphylococcus aureus subsp. aureus MRSA252 2861182 YP_041313.1 CDS SAR1938 NC_002952.2 2020544 2021008 R No significant database matches to the full length CDS. N-terminal region is similar to Streptococcus pneumoniae transcription regulator SP0333 TR:P72494 (EMBL:Z79691) (64 aa) fasta scores: E(): 2.3, 30.5% id in 59 aa, and Streptococcus pyogenes transcription regulator SPY1934 TR:Q99Y06 (EMBL:AE006617) (68 aa) fasta scores: E(): 0.97, 28.81% id in 59 aa; DNA-binding protein complement(2020544..2021008) Staphylococcus aureus subsp. aureus MRSA252 2861183 YP_041314.1 CDS SAR1939 NC_002952.2 2021366 2021989 R Two-component regulatory system family, response regulator protein. Similar to Bacillus halodurans two-component response regulator BH2213 TR:Q9KAS4 (EMBL:AP001514) (217 aa) fasta scores: E(): 1.6e-28, 47.08% id in 206 aa, and to Bacillus subtilis hypothetical protein YhcZ TR:O07528 (EMBL:Y14079) (214 aa) fasta scores: E(): 6.6e-27, 44.49% id in 209 aa; response regulator complement(2021366..2021989) Staphylococcus aureus subsp. aureus MRSA252 2861184 YP_041315.1 CDS SAR1940 NC_002952.2 2022011 2023123 R Similar to Bacillus subtilis hypothetical protein YhcY TR:O07527 (EMBL:Y14079) (379 aa) fasta scores: E(): 2.4e-47, 40% id in 365 aa, and to the Bacillus halodurans two-component sensor histidine kinase BH2214 TR:Q9KAS3 (EMBL:AP001514) (478 aa) fasta scores: E(): 2.3e-18, 28.72% id in 470 aa. B. halodurans protein is larger in comparison to the CDS and contains extra internal amino acids.; histidine kinase complement(2022011..2023123) Staphylococcus aureus subsp. aureus MRSA252 2861185 YP_041316.1 CDS SAR1941 NC_002952.2 2023286 2024107 D Similar to Bacillus subtilis hypothetical protein YhcT SW:YHCT_BACSU (P54604) (302 aa) fasta scores: E(): 3.5e-29, 39.6% id in 255 aa, and to Lactococcus lactis possible pseudouridine synthase RluA TR:Q9CDU9 (EMBL:AE006439) (288 aa) fasta scores: E(): 3.9e-29, 38.18% id in 275 aa; RNA pseudouridylate synthase 2023286..2024107 Staphylococcus aureus subsp. aureus MRSA252 2861186 YP_041317.1 CDS fumC NC_002952.2 2024563 2025948 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(2024563..2025948) Staphylococcus aureus subsp. aureus MRSA252 2861359 YP_041318.1 CDS SAR1943 NC_002952.2 2026144 2026539 R hypothetical protein complement(2026144..2026539) Staphylococcus aureus subsp. aureus MRSA252 2861187 YP_041319.1 CDS SAR1944 NC_002952.2 2027140 2027292 R hypothetical protein complement(2027140..2027292) Staphylococcus aureus subsp. aureus MRSA252 2861188 YP_041320.1 CDS SAR1945 NC_002952.2 2027317 2027916 R hypothetical protein complement(2027317..2027916) Staphylococcus aureus subsp. aureus MRSA252 2861189 YP_041321.1 CDS SAR1946 NC_002952.2 2028075 2028545 R Similar to Bacillus subtilis methylase homologue CspR TR:Q45512 (EMBL:U58864) (157 aa) fasta scores: E(): 3.5e-42, 64.74% id in 156 aa, and to Bacillus stearothermophilus hypothetical protein SW:YGL3_BACST (P32813) (157 aa) fasta scores: E(): 5.5e-42, 66.24% id in 157 aa; SpoU rRNA methylase complement(2028075..2028545) Staphylococcus aureus subsp. aureus MRSA252 2861190 YP_041322.1 CDS SAR1947 NC_002952.2 2028550 2029677 R Similar to Bacillus halodurans hypothetical protein BH1020 TR:Q9KE38 (EMBL:AP001510) (391 aa) fasta scores: E(): 6.5e-86, 57.45% id in 369 aa, and to Streptococcus pyogenes hypothetical protein SPY0642 TR:Q9A0S6 (EMBL:AE006518) (391 aa) fasta scores: E(): 3.6e-57, 42.81% id in 369 aa; iron-sulfur protein complement(2028550..2029677) Staphylococcus aureus subsp. aureus MRSA252 2861191 YP_041323.1 CDS glnQ NC_002952.2 2029828 2030556 R Similar to Bacillus stearothermophilus glutamine transport ATP-binding protein GlnQ SW:GLNQ_BACST (P27675) (242 aa) fasta scores: E(): 7e-43, 55.83% id in 240 aa, and to Streptococcus pyogenes amino acid ABC transporter SPY1506 TR:Q99YW9 (EMBL:AE006584) (244 aa) fasta scores: E(): 8.5e-49, 65% id in 240 aa. Similar to SAR2502, 54.622% identity (55.319% ungapped) in 238 aa overlap; glutamine transport ATP-binding protein complement(2029828..2030556) Staphylococcus aureus subsp. aureus MRSA252 2859922 YP_041324.1 CDS SAR1949 NC_002952.2 2030543 2032000 R Similar to Streptococcus pyogenes glutamine-binding periplasmic protein SPY0277 TR:Q9A1H0 (EMBL:AE006494) (522 aa) fasta scores: E(): 1.8e-23, 32.61% id in 512 aa, and to Synechocystis sp glutamine-binding periplasmic protein SLL1270 TR:P73544 (EMBL:D90907) (530 aa) fasta scores: E(): 3e-23, 30.3% id in 518 aa. Possible alternative translational start sites; extracellular glutamine-binding protein complement(2030543..2032000) Staphylococcus aureus subsp. aureus MRSA252 2861192 YP_041325.1 CDS SAR1950 NC_002952.2 2032259 2033320 R Similar to Treponema pallidum regulatory protein TP0038 TR:Q56343 (EMBL:AE001189) (350 aa) fasta scores: E(): 1.3e-45, 39.82% id in 344 aa, and to Streptococcus pyogenes probable regulatory protein SPY0851 TR:Q9A0B4 (EMBL:AE006535) (352 aa) fasta scores: E(): 5e-40, 39.65% id in 353 aa; hypothetical protein complement(2032259..2033320) Staphylococcus aureus subsp. aureus MRSA252 2861193 YP_041326.1 CDS perR NC_002952.2 2042134 2042580 R Similar to Bacillus subtilis peroxide operon regulator PerR SW:PERR_BACSU (P71086) (145 aa) fasta scores: E(): 2.4e-37, 67.62% id in 139 aa, and to Bacillus halodurans transcriptional regulator BH0951 TR:Q9JWQ8 (EMBL:AP001510) (145 aa) fasta scores: E(): 9.7e-36, 67.62% id in 139 aa; peroxide operon regulator complement(2042134..2042580) Staphylococcus aureus subsp. aureus MRSA252 2859896 YP_041327.1 CDS SAR1952 NC_002952.2 2042677 2043627 R Similar to Bacillus halodurans D-3-phosphoglycerate dehydrogenase BH0949 TR:Q9KEA4 (EMBL:AP001510) (316 aa) fasta scores: E(): 7.6e-38, 36.59% id in 317 aa, and to Lactococcus lactis dehydrogenase YugC TR:Q9CE59 (EMBL:AE006429) (325 aa) fasta scores: E(): 2.6e-23, 31.15% id in 321 aa; hypothetical protein complement(2042677..2043627) Staphylococcus aureus subsp. aureus MRSA252 2861194 YP_041328.1 CDS SAR1953 NC_002952.2 2043633 2044085 R Similar to Bacillus halodurans bacterioferritin comigratory protein BH0948 TR:Q9KEA5 (EMBL:AP001510) (154 aa) fasta scores: E(): 6.5e-24, 49.3% id in 144 aa, and to Aquifex aeolicus hypothetical protein AQ_495 TR:O66785 (EMBL:AE000692) (161 aa) fasta scores: E(): 6.6e-23, 47.71% id in 153 aa; AhpC/TSA family protein complement(2043633..2044085) Staphylococcus aureus subsp. aureus MRSA252 2861195 YP_041329.1 CDS SAR1954 NC_002952.2 2044169 2045458 D converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate; glutamate-1-semialdehyde aminotransferase 2044169..2045458 Staphylococcus aureus subsp. aureus MRSA252 2861196 YP_041330.1 CDS SAR1955 NC_002952.2 2045751 2046845 D Similar to Bacillus subtilis hypothetical protein YgaE TR:P71083 (EMBL:Z82044) (353 aa) fasta scores: E(): 1.9e-38, 38.01% id in 363 aa, and to Bacillus halodurans hypothetical protein BH0942 TR:Q9KEB1 (EMBL:AP001510) (360 aa) fasta scores: E(): 2.1e-34, 33.6% id in 363 aa; hypothetical protein 2045751..2046845 Staphylococcus aureus subsp. aureus MRSA252 2861197 YP_041331.1 CDS SAR1956 NC_002952.2 2047036 2048772 R Similar to Bacillus halodurans ABC transporter BH0941 TR:Q9KEB2 (EMBL:AP001510) (584 aa) fasta scores: E(): 1.8e-132, 64.12% id in 577 aa, and to Bacillus subtilis ABC transporter ATP-binding protein YgaD TR:P71082 (EMBL:Z82044) (589 aa) fasta scores: E(): 3.6e-130, 61.24% id in 578 aa; ABC transporter ATP-binding protein complement(2047036..2048772) Staphylococcus aureus subsp. aureus MRSA252 2861198 YP_041332.1 CDS SAR1957 NC_002952.2 2049063 2049605 R Similar to Bacillus halodurans hypothetical protein BH0940 TR:Q9KEB3 (EMBL:AP001510) (175 aa) fasta scores: E(): 1.3e-44, 63.79% id in 174 aa, and to Lactococcus lactis hypothetical protein YjjG TR:Q9CGX3 (EMBL:AE006331) (176 aa) fasta scores: E(): 3.8e-44, 59.19% id in 174 aa; hypothetical protein complement(2049063..2049605) Staphylococcus aureus subsp. aureus MRSA252 2861199 YP_041333.1 CDS SAR1958 NC_002952.2 2049908 2050945 R Similar to Salmonella typhimurium A/G-specific adenine glycosylase MutY SW:MUTY_SALTY (Q05869) (350 aa) fasta scores: E(): 1.1e-34, 33.72% id in 344 aa, and to Bacillus subtilis hypothetical protein YfhQ TR:O31584 (EMBL:Z99108) (369 aa) fasta scores: E(): 1.5e-53, 44.98% id in 349 aa; HhH-GPD superfamily base excision DNA repair protein complement(2049908..2050945) Staphylococcus aureus subsp. aureus MRSA252 2861200 YP_041334.1 CDS SAR1959 NC_002952.2 2051097 2052074 D Similar to Bacillus subtilis hypothetical protein YfhP TR:O31583 (EMBL:Z99108) (327 aa) fasta scores: E(): 1.1e-52, 42.76% id in 325 aa, and to Bacillus halodurans hypothetical protein BH0929 TR:Q9KEC4 (EMBL:AP001510) (327 aa) fasta scores: E(): 1.5e-50, 43.29% id in 328 aa; hypothetical protein 2051097..2052074 Staphylococcus aureus subsp. aureus MRSA252 2861201 YP_041335.1 CDS SAR1960 NC_002952.2 2052335 2053171 R Similar to Bacillus subtilis teichoic acid translocation permease TagG SW:TAGG_BACSU (P42953) (275 aa) fasta scores: E(): 0.00014, 24.61% id in 195 aa, and to Archaeoglobus fulgidus polysaccharide ABC transporter permease AF0289 TR:O29952 (EMBL:AE001085) (252 aa) fasta scores: E(): 0.12, 22.3% id in 260 aa; hypothetical protein complement(2052335..2053171) Staphylococcus aureus subsp. aureus MRSA252 2861202 YP_041336.1 CDS SAR1961 NC_002952.2 2053180 2054697 R Similar to Bacillus subtilis teichoic acid translocation ATP-binding protein TagH SW:TAGH_BACSU (P42954) (527 aa) fasta scores: E(): 2.4e-12, 24.04% id in 445 aa, and to Lactococcus lactis teichoic acid ABC transporter ATP binding protein TagH TR:Q9CH26 (EMBL:AE006326) (466 aa) fasta scores: E(): 1.4e-07, 22.22% id in 396 aa; hypothetical protein complement(2053180..2054697) Staphylococcus aureus subsp. aureus MRSA252 2861203 YP_041337.1 CDS SAR1962 NC_002952.2 2054712 2055026 R Similar to Bacillus subtilis hypothetical protein YfhH TR:O31576 (EMBL:Z99108) (104 aa) fasta scores: E(): 2.5e-11, 40.59% id in 101 aa, and to Bacillus halodurans hypothetical protein BH0925 TR:Q9KEC8 (EMBL:AP001510) (108 aa) fasta scores: E(): 1.4e-10, 42.15% id in 102 aa; hypothetical protein complement(2054712..2055026) Staphylococcus aureus subsp. aureus MRSA252 2861204 YP_041338.1 CDS recX NC_002952.2 2055004 2055822 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(2055004..2055822) Staphylococcus aureus subsp. aureus MRSA252 2861205 YP_041339.1 CDS SAR1964 NC_002952.2 2056083 2056892 R monofunctional; catalyzes the elongation of glycan strands in cell wall biosynthesis; glycosyltransferase complement(2056083..2056892) Staphylococcus aureus subsp. aureus MRSA252 2861206 YP_041340.1 CDS SAR1965 NC_002952.2 2057233 2057748 R Similar to Bacillus subtilis hypothetical protein YraA SW:YRAA_BACSU (O06006) (154 aa) fasta scores: E(): 5.5e-29, 56.95% id in 151 aa, and to Escherichia coli hypothetical protein YhbO SW:YHBO_ECOLI (P45470) (172 aa) fasta scores: E(): 5.4e-28, 49.41% id in 172 aa; ThiJ/PfpI family protein complement(2057233..2057748) Staphylococcus aureus subsp. aureus MRSA252 2861207 YP_041341.1 CDS SAR1966 NC_002952.2 2057878 2058039 R Poor database matches. Similar to Bacillus subtilis hypothetical protein YfjT TR:O35041 (EMBL:Z99108) (61 aa) fasta scores: E(): 0.0017, 42.3% id in 52 aa; hypothetical protein complement(2057878..2058039) Staphylococcus aureus subsp. aureus MRSA252 2861208 YP_041342.1 CDS SAR1967 NC_002952.2 2058263 2059414 D Similar to Bacillus halodurans hypothetical protein BH0889 TR:Q9KEG3 (EMBL:AP001510) (374 aa) fasta scores: E(): 2.2e-89, 56.38% id in 376 aa. N-terminus is similar to Bacillus subtilis hypothetical protein YfkA TR:O34400 (EMBL:Z99108) (154 aa) fasta scores: E(): 1.9e-35, 61.58% id in 151 aa. C-terminus is similar to Bacillus subtilis hypothetical protein YfkB TR:O34868 (EMBL:Z99108) (153 aa) fasta scores: E(): 1.9e-35, 63.94% id in 147 aa; hypothetical protein 2058263..2059414 Staphylococcus aureus subsp. aureus MRSA252 2861209 YP_041343.1 CDS SAR1968 NC_002952.2 2059674 2060204 R Similar to Bacillus halodurans acyl-CoA thioester hydrolase BH2302 TR:Q9KAI5 (EMBL:AP001515) (162 aa) fasta scores: E(): 5.2e-23, 46.1% id in 154 aa, and to Bacillus subtilis acyl-CoA thioester hydrolase YkhA SW:YKHA_BACSU (P49851) (179 aa) fasta scores: E(): 1e-22, 50% id in 150 aa; hypothetical protein complement(2059674..2060204) Staphylococcus aureus subsp. aureus MRSA252 2861210 YP_041344.1 CDS SAR1969 NC_002952.2 2060294 2061541 R Similar to Streptococcus thermophilus aminopeptidase PepS SW:PEPS_STRTR (Q9X4A7) (413 aa) fasta scores: E(): 9.9e-71, 46.48% id in 413 aa, and to Bacillus subtilis aminopeptidase AmpS SW:AMPS_BACSU (P39762) (410 aa) fasta scores: E(): 3.1e-73, 47.33% id in 412 aa; aminopeptidase complement(2060294..2061541) Staphylococcus aureus subsp. aureus MRSA252 2861211 YP_041345.1 CDS SAR1970 NC_002952.2 2061553 2061768 R Similar to Bacillus subtilis hypothetical protein YfkK TR:O35019 (EMBL:Z99108) (71 aa) fasta scores: E(): 0.0036, 40% id in 55 aa, and to Bacillus halodurans hypothetical protein BH2488 TR:Q9KA06 (EMBL:AP001515) (73 aa) fasta scores: E(): 0.0002, 39.7% id in 68 aa; hypothetical protein complement(2061553..2061768) Staphylococcus aureus subsp. aureus MRSA252 2861212 YP_041346.1 CDS SAR1971 NC_002952.2 2061900 2062364 D Similar to Rattus norvegicus low molecular weight phosphotyrosine protein phosphatase AcP1 SW:PPAC_RAT (P41498) (159 aa) fasta scores: E(): 8.6e-13, 36.05% id in 147 aa, and to Bacillus subtilis hypothetical protein YfkJ TR:O35016 (EMBL:Z99108) (156 aa) fasta scores: E(): 5.2e-23, 45.57% id in 158 aa; low molecular weight phosphotyrosine protein phosphatase 2061900..2062364 Staphylococcus aureus subsp. aureus MRSA252 2861213 YP_041347.1 CDS SAR1972 NC_002952.2 2062371 2062646 D hypothetical protein 2062371..2062646 Staphylococcus aureus subsp. aureus MRSA252 2861214 YP_041348.1 CDS SAR1973 NC_002952.2 2062924 2064141 D C-terminal region is similar to Bacillus cereus hypothetical protein YfkH TR:Q9XBK8 (EMBL:AJ010131) (289 aa) fasta scores: E(): 1.2e-34, 37.18% id in 277 aa, and Bacillus subtilis hypothetical protein YfkH TR:O34437 (EMBL:Z99108) (275 aa) fasta scores: E(): 3.7e-33, 39.33% id in 272 aa. CDS contains extra residues at the N-terminus in comparison to orthologues; hypothetical protein 2062924..2064141 Staphylococcus aureus subsp. aureus MRSA252 2861215 YP_041349.1 CDS SAR1974 NC_002952.2 2064254 2064883 R Two-component regulatory system family, response regulator protein. Similar to Bacillus halodurans two-component response regulator BH1200 TR:Q9KDL2 (EMBL:AP001511) (209 aa) fasta scores: E(): 3e-36, 55.28% id in 208 aa, and to Lactococcus lactis two-component system regulator LlrD TR:Q9CH48 (EMBL:AE006323) (209 aa) fasta scores: E(): 5.3e-35, 53.88% id in 206 aa; response regulator complement(2064254..2064883) Staphylococcus aureus subsp. aureus MRSA252 2861216 YP_041350.1 CDS vraS NC_002952.2 2064873 2065916 R Previously sequenced as Staphylococcus aureus histidine kinase sensor, up-regulated in vancomycin-resistant strains, VraS TR:Q9KWK8 (EMBL:AB035448) (347 aa) fasta scores: E(): 3e-115, 99.71% id in 347 aa. Similar to Bacillus subtilis hypothetical protein YvqE TR:O32198 (EMBL:Z99120) (360 aa) fasta scores: E(): 8.9e-32, 40.47% id in 336 aa; histidine kinase sensor complement(2064873..2065916) Staphylococcus aureus subsp. aureus MRSA252 2860430 YP_041351.1 CDS SAR1976 NC_002952.2 2065913 2066614 R Similar to Streptococcus pyogenes hypothetical protein SPY1623 TR:Q99YN1 (EMBL:AE006593) (228 aa) fasta scores: E(): 3.7e-05, 21.22% id in 212 aa, and to Bacillus subtilis hypothetical protein YvqF TR:O32199 (EMBL:Z99120) (241 aa) fasta scores: E(): 0.00046, 26.27% id in 236 aa; hypothetical protein complement(2065913..2066614) Staphylococcus aureus subsp. aureus MRSA252 2861217 YP_041352.1 CDS SAR1977 NC_002952.2 2066629 2067015 R hypothetical protein complement(2066629..2067015) Staphylococcus aureus subsp. aureus MRSA252 2861218 YP_041353.1 CDS SAR1978 NC_002952.2 2067232 2067990 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(2067232..2067990) Staphylococcus aureus subsp. aureus MRSA252 2861219 YP_041354.1 CDS SAR1980 NC_002952.2 2068690 2069676 D N-terminus is similar to the N-terminal regions of Bacillus halodurans hypothetical protein BH2644 TR:Q9K9K2 (EMBL:AP001516) (354 aa) fasta scores: E(): 7.7e-26, 34.04% id in 279 aa, and Bacillus subtilis hypothetical protein YgaE TR:P71083 (EMBL:Z82044) (353 aa) fasta scores: E(): 3.1e-12, 29.79% id in 292 aa; hypothetical protein 2068690..2069676 Staphylococcus aureus subsp. aureus MRSA252 2861220 YP_041355.1 CDS SAR1981 NC_002952.2 2069865 2070278 R No significant database matches. Possible alternative translational start sites; hypothetical protein complement(2069865..2070278) Staphylococcus aureus subsp. aureus MRSA252 2861221 YP_041356.1 CDS SAR1982 NC_002952.2 2070503 2071234 R Similar to the C-terminal region of Pyrococcus kodakaraensis probable cobyric acid synthase CobQ SW:COBQ_PYRKO (O33475) (472 aa) fasta scores: E(): 0.00014, 26.88% id in 186 aa, and to the full length Heliobacillus mobilis cobyric acid synthase CobQ TR:Q9ZGG8 (EMBL:AF080002) (252 aa) fasta scores: E(): 5e-35, 48.61% id in 216 aa; hypothetical protein complement(2070503..2071234) Staphylococcus aureus subsp. aureus MRSA252 2861222 YP_041357.1 CDS SAR1983 NC_002952.2 2071236 2072549 R Similar to Lactococcus lactis hypothetical protein YlbD TR:Q9CGJ0 (EMBL:AE006342) (449 aa) fasta scores: E(): 9.5e-42, 35.57% id in 447 aa, and to Heliobacillus mobilis UDP-N-acetylmuramyl tripeptide synthetase MurC TR:Q9ZGG7 (EMBL:AF080002) (455 aa) fasta scores: E(): 8.7e-27, 35.79% id in 447 aa; Mur ligase complement(2071236..2072549) Staphylococcus aureus subsp. aureus MRSA252 2861732 YP_041358.1 CDS SAR1984 NC_002952.2 2072841 2073341 D Similar to Escherichia coli ferritin 1 FtnA SW:FTNA_ECOLI (P23887) (165 aa) fasta scores: E(): 1e-18, 35.62% id in 160 aa, and to Bacillus halodurans ferritin BH1124 TR:Q9KDT7 (EMBL:AP001511) (169 aa) fasta scores: E(): 2.5e-33, 54.21% id in 166 aa; ferritin 2072841..2073341 Staphylococcus aureus subsp. aureus MRSA252 2861733 YP_041359.1 CDS SAR1985 NC_002952.2 2073732 2074286 D Similar to Caulobacter crescentus exonuclease CC1523 TR:Q9A841 (EMBL:AE005827) (202 aa) fasta scores: E(): 1.3e-13, 31.41% id in 156 aa, and to an internal region of Staphylococcus aureus DNA polymerase III PolC-type PolC SW:DPO3_STAAU (Q53665) (1436 aa) fasta scores: E(): 7.3e-08, 25.78% id in 190 aa; exonuclease 2073732..2074286 Staphylococcus aureus subsp. aureus MRSA252 2861642 YP_041360.1 CDS SAR1986 NC_002952.2 2074353 2075423 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(2074353..2075423) Staphylococcus aureus subsp. aureus MRSA252 2859554 YP_041361.1 CDS SAR1987 NC_002952.2 2075670 2076200 R Similar to Streptococcus downei surface protein antigen gene repressor protein Par TR:Q06370 (EMBL:D13323) (203 aa) fasta scores: E(): 0.0071, 30.07% id in 143 aa, and to Streptococcus criceti probable surface antigen negative regulator Par TR:BAB59133 (EMBL:AB042239) (183 aa) fasta scores: E(): 0.01, 26.7% id in 161 aa; hypothetical protein complement(2075670..2076200) Staphylococcus aureus subsp. aureus MRSA252 2859728 YP_041362.1 CDS SAR1988 NC_002952.2 2076370 2077731 R Similar to Bacillus halodurans RNA methyltransferase BH0687 TR:Q9KF10 (EMBL:AP001509) (458 aa) fasta scores: E(): 7.7e-89, 48.11% id in 451 aa, and to Bacillus subtilis hypothetical protein YefA TR:O31503 (EMBL:Z99107) (459 aa) fasta scores: E(): 4.8e-88, 49.66% id in 453 aa; RNA methyltransferase complement(2076370..2077731) Staphylococcus aureus subsp. aureus MRSA252 2859729 YP_041363.1 CDS SAR1989 NC_002952.2 2077812 2078759 R similar to YegS from E. coli; lipid kinase complement(2077812..2078759) Staphylococcus aureus subsp. aureus MRSA252 2859730 YP_041364.1 CDS gatB NC_002952.2 2079582 2081009 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(2079582..2081009) Staphylococcus aureus subsp. aureus MRSA252 2860692 YP_041365.1 CDS gatA NC_002952.2 2081022 2082479 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(2081022..2082479) Staphylococcus aureus subsp. aureus MRSA252 2860691 YP_041366.1 CDS gatC NC_002952.2 2082481 2082783 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(2082481..2082783) Staphylococcus aureus subsp. aureus MRSA252 2860693 YP_041367.1 CDS putP NC_002952.2 2083150 2084688 D Similar to Staphylococcus aureus high affinity proline permease PutP TR:O30986 (EMBL:AF024571) (497 aa) fasta scores: E(): 5.5e-176, 97.97% id in 494 aa, and to Bacillus subtilis osmoregulated proline transporter OpuE SW:OPUE_BACSU (O06493) (492 aa) fasta scores: E(): 4.3e-100, 55.25% id in 476 aa; high affinity proline permease 2083150..2084688 Staphylococcus aureus subsp. aureus MRSA252 2860034 YP_041368.1 CDS SAR1995 NC_002952.2 2084777 2085976 R Similar to Bacillus subtilis hypothetical protein YerH TR:O34629 (EMBL:Z99107) (396 aa) fasta scores: E(): 2.5e-43, 35.55% id in 405 aa, and to Bacillus halodurans hypothetical protein BH0650 TR:Q9KF36 (EMBL:AP001509) (392 aa) fasta scores: E(): 2.8e-21, 27.98% id in 411 aa; lipoprotein complement(2084777..2085976) Staphylococcus aureus subsp. aureus MRSA252 2859731 YP_041369.1 CDS lig NC_002952.2 2085989 2087992 R Previously sequenced as Staphylococcus aureus DNA ligase Lig TR:Q9AIU7 (EMBL:AF234833) (667 aa) fasta scores: E(): 0, 99.55% id in 667 aa. Similar to Bacillus subtilis DNA ligase LigA SW:DNLJ_BACSU (O31498) (668 aa) fasta scores: E(): 4.1e-153, 61.79% id in 657 aa; DNA ligase complement(2085989..2087992) Staphylococcus aureus subsp. aureus MRSA252 2859803 YP_041370.1 CDS pcrA NC_002952.2 2087996 2090188 R Similar to Bacillus subtilis ATP-dependent DNA helicase PcrA SW:PCRA_BACSU (O34580) (739 aa) fasta scores: E(): 6.1e-157, 59.73% id in 740 aa. Previously sequenced as Staphylococcus aureus ATP-dependent DNA helicase PcrA SW:PCRA_STAAU (Q53727) (675 aa) fasta scores: E(): 0, 99.85% id in 665 aa; ATP-dependent DNA helicase complement(2087996..2090188) Staphylococcus aureus subsp. aureus MRSA252 2859887 YP_041371.1 CDS pcrB NC_002952.2 2090185 2090877 R PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer; geranylgeranylglyceryl phosphate synthase complement(2090185..2090877) Staphylococcus aureus subsp. aureus MRSA252 2859888 YP_041372.1 CDS SAR1999 NC_002952.2 2091060 2091362 R Similar to Bacillus subtilis hypothetical protein YerC TR:O34975 (EMBL:Z99107) (104 aa) fasta scores: E(): 1.3e-24, 69.14% id in 94 aa, and to Bacillus halodurans hypothetical protein BH0639 TR:Q9KF47 (EMBL:AP001509) (100 aa) fasta scores: E(): 5.4e-24, 68.08% id in 94 aa; hypothetical protein complement(2091060..2091362) Staphylococcus aureus subsp. aureus MRSA252 2859732 YP_041373.1 CDS purB NC_002952.2 2091471 2092766 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(2091471..2092766) Staphylococcus aureus subsp. aureus MRSA252 2860159 YP_041374.1 CDS SAR2001 NC_002952.2 2093617 2094783 D Similar to Staphylococcus aureus cysteine protease (V8 protease) precursor BspB TR:Q9EYW7 (EMBL:AF309515) (393 aa) fasta scores: E(): 2.4e-47, 40.2% id in 398 aa. C-terminal region is identical to Staphylococcus aureus staphopain protease SW:STPA_STAAU (P81297) (174 aa) fasta scores: E(): 5.4e-64, 100% id in 174 aa; staphopain protease 2093617..2094783 Staphylococcus aureus subsp. aureus MRSA252 2859733 YP_041375.1 CDS SAR2002 NC_002952.2 2094814 2095137 D Poor database matches. Similar to Staphylococcus aureus Ssp serine protease (V8 protease) operon hypothetical protein SspC TR:Q9EYW6 (EMBL:AF309515) (109 aa) fasta scores: E(): 9.6, 22.68% id in 97 aa; hypothetical protein 2094814..2095137 Staphylococcus aureus subsp. aureus MRSA252 2859734 YP_041376.1 CDS SAR2003 NC_002952.2 2095431 2095604 R Similar to Bacillus halodurans hypothetical protein BH0622 TR:Q9KF64 (EMBL:AP001509) (65 aa) fasta scores: E(): 2.2e-07, 49.12% id in 57 aa, and to Bacillus subtilis hypothetical protein YebG TR:O34700 (EMBL:Z99107) (65 aa) fasta scores: E(): 2.1e-06, 43.1% id in 58 aa; hypothetical protein complement(2095431..2095604) Staphylococcus aureus subsp. aureus MRSA252 2859735 YP_041377.1 CDS SAR2004 NC_002952.2 2095585 2096187 R Similar to Bacillus halodurans hypothetical protein BH0621 TR:Q9KF65 (EMBL:AP001509) (179 aa) fasta scores: E(): 1.3e-39, 60.11% id in 178 aa. N-terminal region is similar to Bacillus subtilis hypothetical protein YebE TR:O34695 (EMBL:Z99107) (80 aa) fasta scores: E(): 4.2e-11, 58.33% id in 72 aa. C-terminal region is similar to Bacillus subtilis hypothetical protein YebF TR:O34624 (EMBL:Z99107) (88 aa) fasta scores: E(): 2.3e-17, 59.09% id in 88 aa; hypothetical protein complement(2095585..2096187) Staphylococcus aureus subsp. aureus MRSA252 2859736 YP_041378.1 CDS nadE NC_002952.2 2096457 2097278 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(2096457..2097278) Staphylococcus aureus subsp. aureus MRSA252 2859737 YP_041379.1 CDS SAR2006 NC_002952.2 2097271 2098740 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(2097271..2098740) Staphylococcus aureus subsp. aureus MRSA252 2859738 YP_041380.1 CDS SAR2007 NC_002952.2 2098924 2100000 D Similar to an internal region of Homo sapiens inducible nitric oxide synthase NOS2 SW:NS2A_HUMAN (P35228) (1153 aa) fasta scores: E(): 4.5e-38, 42.13% id in 356 aa, and to the full length Bacillus halodurans nitric oxide synthase BH0823 TR:Q9KEM9 (EMBL:AP001509) (366 aa) fasta scores: E(): 3.4e-69, 50.43% id in 349 aa; oxygenase 2098924..2100000 Staphylococcus aureus subsp. aureus MRSA252 2859739 YP_041381.1 CDS SAR2008 NC_002952.2 2100020 2100814 D Similar to the C-terminal region of Pseudomonas stutzeri bifunctional P-protein [includes: chorismate mutase, chorismate mutase/prephenate dehydratase] PheA SW:PHEA_PSEST (P27603) (365 aa) fasta scores: E(): 3.6e-18, 30.25% id in 271 aa, and to Methanococcus jannaschii probable prephenate dehydratase MJ0637 SW:PHEA_METJA (Q58054) (272 aa) fasta scores: E(): 7.6e-22, 33.33% id in 270 aa; prephenate dehydratase 2100020..2100814 Staphylococcus aureus subsp. aureus MRSA252 2859740 YP_041382.1 CDS SAR2009 NC_002952.2 2101004 2102566 R Similar to Oryctolagus cuniculus renal sodium/dicarboxylate cotransporter NaDC-1 SW:NDC1_RABIT (Q28615) (593 aa) fasta scores: E(): 2.3e-21, 35.54% id in 543 aa, and to Arabidopsis thaliana sodium sulfate or dicarboxylate transporter TR:Q9MAW4 (EMBL:AB043024) (540 aa) fasta scores: E(): 1.2e-31, 33.19% id in 482 aa; sodium:sulfate symporter complement(2101004..2102566) Staphylococcus aureus subsp. aureus MRSA252 2859741 YP_041383.1 CDS SAR2010 NC_002952.2 2102771 2103868 R Poor database matches. Similar to bacteriophage B103 pre-neck appendage protein (late protein gp12) SW:VG12_BPB03 (Q37893) (860 aa) fasta scores: E(): 0.012, 24.39% id in 373 aa; hypothetical protein complement(2102771..2103868) Staphylococcus aureus subsp. aureus MRSA252 2859742 YP_041384.1 CDS SAR2011 NC_002952.2 2104241 2104801 D Similar to Mycobacterium smegmatis nicotinamidase/pyrazinamidase PncA TR:Q9ZF59 (EMBL:AF117900) (187 aa) fasta scores: E(): 1.1e-05, 30.67% id in 163 aa, and to Bacillus halodurans pyrazinamidase/nicotinamidase BH3777 TR:Q9K6F2 (EMBL:AP001520) (183 aa) fasta scores: E(): 6.2e-40, 54.74% id in 179 aa; isochorismatase 2104241..2104801 Staphylococcus aureus subsp. aureus MRSA252 2859743 YP_041385.1 CDS ppaC NC_002952.2 2104848 2105783 D catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase 2104848..2105783 Staphylococcus aureus subsp. aureus MRSA252 2860000 YP_041386.1 CDS SAR2013 NC_002952.2 2106200 2107579 D Similar to Homo sapiens fatty aldehyde dehydrogenase ALDH10 SW:DHA4_HUMAN (P51648) (485 aa) fasta scores: E(): 1.4e-78, 45.35% id in 452 aa, and to Bacillus subtilis probable aldehyde dehydrogenase ywdh ywdh or ipa-58R SW:DHA2_BACSU (P39616) (457 aa) fasta scores: E(): 8.3e-92, 50.78% id in 447 aa; aldehyde dehydrogenase 2106200..2107579 Staphylococcus aureus subsp. aureus MRSA252 2859744 YP_041387.1 CDS SAR2014 NC_002952.2 2107699 2108727 R Similar to Bacillus subtilis hypothetical protein YkgB SW:YKGB_BACSU (O34499) (349 aa) fasta scores: E(): 3.4e-41, 37.79% id in 344 aa, and to Lactococcus lactis hypothetical protein SW:YADB_LACLC (O86281) (341 aa) fasta scores: E(): 2.1e-36, 34.6% id in 341 aa; hypothetical protein complement(2107699..2108727) Staphylococcus aureus subsp. aureus MRSA252 2859745 YP_041388.1 CDS SAR2015 NC_002952.2 2108998 2109399 D C-terminal region is similar to Bacillus anthracis plasmid pXO2 hypothetical protein pXO2-70 TR:Q9RMW4 (EMBL:AF188935) (113 aa) fasta scores: E(): 8.7e-10, 35.13% id in 111 aa, and bacteriophage SPBc2 hypothetical protein YolD TR:O64030 (EMBL:AF020713) (110 aa) fasta scores: E(): 8.1e-07, 39.02% id in 82 aa; hypothetical protein 2108998..2109399 Staphylococcus aureus subsp. aureus MRSA252 2859746 YP_041389.1 CDS SAR2016 NC_002952.2 2109456 2109629 R hypothetical protein complement(2109456..2109629) Staphylococcus aureus subsp. aureus MRSA252 2859747 YP_041390.1 CDS SAR2017 NC_002952.2 2110080 2111120 D Poor database matches. N-terminus is weakly similar to the N-terminal region of Rhizobium loti acyl-CoA-6-aminopenicillanic acid acyltransferase MLL9373 TR:BAB54980 (EMBL:AP003016) (334 aa) fasta scores: E(): 0.017, 21.56% id in 269 aa; hypothetical protein 2110080..2111120 Staphylococcus aureus subsp. aureus MRSA252 2859748 YP_041391.1 CDS SAR2018 NC_002952.2 2111177 2112019 R Poor database matches. Similar to the N-terminal regions of Staphylococcus sciuri penicillin-binding protein 2' MecA TR:O54286 (EMBL:Y13096) (668 aa) fasta scores: E(): 3.8, 22.93% id in 279 aa, and to Staphylococcus epidermidis penicillin binding protein 2' MecA TR:Q54113 (EMBL:X52592) (668 aa) fasta scores: E(): 4.4, 23.29% id in 279 aa; hypothetical protein complement(2111177..2112019) Staphylococcus aureus subsp. aureus MRSA252 2859749 YP_041392.1 CDS SAR2019 NC_002952.2 2112016 2112573 R Similar to Streptococcus pyogenes hypothetical protein SPY2173 TR:Q99XJ8 (EMBL:AE006634) (195 aa) fasta scores: E(): 0.0068, 27% id in 200 aa, and to Caulobacter crescentus hypothetical protein CC3409 TR:Q9A2Z7 (EMBL:AE006001) (187 aa) fasta scores: E(): 0.011, 22.77% id in 180 aa; hypothetical protein complement(2112016..2112573) Staphylococcus aureus subsp. aureus MRSA252 2859750 YP_041393.1 CDS SAR2020 NC_002952.2 2112633 2113157 R Poor database matches. Weakly similar to Candidatus Carsonella ruddii alkyl hydroperoxide reductase small subunit AhpC TR:Q9AIZ1 (EMBL:AF211134) (177 aa) fasta scores: E(): 10, 21.89% id in 169 aa; hypothetical protein complement(2112633..2113157) Staphylococcus aureus subsp. aureus MRSA252 2859751 YP_041394.1 CDS SAR2021 NC_002952.2 2113278 2113841 D Poor database matches. Weakly similar to Arabidopsis thaliana thioredoxin-like protein TR:Q9LVI2 (EMBL:AB019230) (175 aa) fasta scores: E(): 0.8, 25.82% id in 151 aa; hypothetical protein 2113278..2113841 Staphylococcus aureus subsp. aureus MRSA252 2859752 YP_041395.1 CDS SAR2022 NC_002952.2 2113905 2114645 R Weakly similar to Staphylococcus epidermidis membrane spanning protein SmpA TR:Q54139 (EMBL:Z30586) (256 aa) fasta scores: E(): 0.00053, 23.75% id in 261 aa, and to Staphylococcus hominis potential membrane spanning protein SmpB TR:Q54315 (EMBL:Z30587) (256 aa) fasta scores: E(): 0.00068, 24.52% id in 261 aa; hypothetical protein complement(2113905..2114645) Staphylococcus aureus subsp. aureus MRSA252 2859753 YP_041396.1 CDS SAR2023 NC_002952.2 2114645 2115517 R Similar to Streptococcus pyogenes ABC transporter SPY1784 TR:Q99YB1 (EMBL:AE006605) (300 aa) fasta scores: E(): 1.3e-19, 33.21% id in 286 aa, and to Staphylococcus aureus potential ABC transporter StpC TR:Q53763 (EMBL:Z30588) (231 aa) fasta scores: E(): 1.9e-19, 41.9% id in 210 aa; ABC transporter ATP-binding protein complement(2114645..2115517) Staphylococcus aureus subsp. aureus MRSA252 2859754 YP_041397.1 CDS SAR2024 NC_002952.2 2115514 2116194 R Similar to Phytophthora infestans mitochondrial SecY-independent transporter protein YMF16 TR:Q9T238 (EMBL:U17009) (248 aa) fasta scores: E(): 0.079, 26.57% id in 207 aa, and to Pyrococcus horikoshii hypothetical protein PH1493 TR:O59162 (EMBL:AP000006) (232 aa) fasta scores: E(): 0.2, 24.87% id in 205 aa; hypothetical protein complement(2115514..2116194) Staphylococcus aureus subsp. aureus MRSA252 2859755 YP_041398.1 CDS SAR2025 NC_002952.2 2116195 2117091 R Similar to Bacillus halodurans ABC transporter BH0652 TR:Q9KF34 (EMBL:AP001509) (288 aa) fasta scores: E(): 6.4e-37, 42.85% id in 280 aa, and to Thermotoga maritima ABC transporter ATP-binding protein TM1028 TR:Q9X0B8 (EMBL:AE001764) (293 aa) fasta scores: E(): 1.8e-18, 31.46% id in 286 aa; ABC transporter ATP-binding protein complement(2116195..2117091) Staphylococcus aureus subsp. aureus MRSA252 2859756 YP_041399.1 CDS SAR2026 NC_002952.2 2117088 2117543 R Similar to Bacillus halodurans transcriptional regulator BH0651 TR:Q9KF35 (EMBL:AP001509) (123 aa) fasta scores: E(): 1.3e-18, 52.03% id in 123 aa, and to Bacillus firmus hypothetical protein TR:O87562 (EMBL:AF084104) (119 aa) fasta scores: E(): 5.3e-11, 40.17% id in 117 aa; GntR family transcriptional regulator complement(2117088..2117543) Staphylococcus aureus subsp. aureus MRSA252 2859757 YP_041400.1 CDS SAR2027 NC_002952.2 2117726 2117902 R hypothetical protein complement(2117726..2117902) Staphylococcus aureus subsp. aureus MRSA252 2859758 YP_041401.1 CDS SAR2027a NC_002952.2 2118144 2118242 R Doubtful CDS. No database matches; hypothetical protein complement(2118144..2118242) Staphylococcus aureus subsp. aureus MRSA252 2859759 YP_041402.1 CDS SAR2028 NC_002952.2 2118442 2119728 D Similar to Bacillus circulans aspartate aminotransferase TR:Q59197 (EMBL:X94433) (432 aa) fasta scores: E(): 4e-70, 46.65% id in 433 aa. N-terminus is similar to the N-terminal region of Escherichia coli aspartate aminotransferase AspC SW:AAT_ECOLI (P00509) (396 aa) fasta scores: E(): 3.5e-07, 23.19% id in 332 aa; hypothetical protein 2118442..2119728 Staphylococcus aureus subsp. aureus MRSA252 2859760 YP_041403.1 CDS SAR2029 NC_002952.2 2119976 2121622 R Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 1e-198, 99.270% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 4.7e-99, 51.923% id in 520 aa; transposase complement(2119976..2121622) Staphylococcus aureus subsp. aureus MRSA252 2859761 YP_041404.1 CDS SAR2030 NC_002952.2 2121920 2123989 R Similar to Staphylococcus aureus mammalian extracellular protein-binding protein, major histocompatibility complex (MHC) class III analog TR:Q53599 (EMBL:U20503) (689 aa) fasta scores: E(): 0, 94.77% id in 689 aa; MHC class II analog complement(2121920..2123989) Staphylococcus aureus subsp. aureus MRSA252 2859762 YP_041405.1 CDS SAR2032 NC_002952.2 2124947 2125126 D hypothetical protein 2124947..2125126 Staphylococcus aureus subsp. aureus MRSA252 2859763 YP_041406.1 CDS SAR2033 NC_002952.2 2125150 2125458 D hypothetical protein 2125150..2125458 Staphylococcus aureus subsp. aureus MRSA252 2859764 YP_041407.1 CDS SAR2034 NC_002952.2 2125437 2125697 D hypothetical protein 2125437..2125697 Staphylococcus aureus subsp. aureus MRSA252 2861484 YP_041408.1 CDS SAR2035 NC_002952.2 2125750 2126100 R No significant database matches. Similar to SAR1131, 50.000% identity (50.893% ungapped) in 114 aa overlap; hypothetical protein complement(2125750..2126100) Staphylococcus aureus subsp. aureus MRSA252 2861485 YP_041409.1 CDS chp NC_002952.2 2126786 2127235 D secreted protein that specifically inhibits the activation of neutrophils and monocytes by binding to the formylated peptide receptor and the C5a receptor; blocks neutrophil migration towards the infection site and hinders the establishment of the initial defense against the infection; chemotaxis-inhibiting protein CHIPS 2126786..2127235 Staphylococcus aureus subsp. aureus MRSA252 2861356 YP_041410.1 CDS sak NC_002952.2 2128315 2128806 R Highly similar to Staphylococcus aureus plasminogen activator staphylokinase precursor Sak SW:SAK_STAAU (P00802) (163 aa) fasta scores: E(): 9.5e-61, 98.77% id in 163 aa, and to bacteriophage P42D staphylokinase precursor Sak SW:SAK_BPP42 (P15240) (163 aa) fasta scores: E(): 2.2e-59, 97.54% id in 163 aa; staphylokinase precursor complement(2128315..2128806) Staphylococcus aureus subsp. aureus MRSA252 2861465 YP_041411.1 CDS SAR2040 NC_002952.2 2128998 2129753 R Similar to the N-terminal region of Staphylococcus aureus autolysin, peptidoglycan hydrolase (N-acetylmuramyl-L-alanine amidase) LytA SW:ALYS_STAAU (P24556) (481 aa) fasta scores: E(): 6.3e-08, 29.61% id in 260 aa, and to the full length Staphylococcus aureus prophage phiPV83 lytic enzyme (N-acetylmuramyl-L-alanine amidase) TR:Q9MBN4 (EMBL:AB044554) (251 aa) fasta scores: E(): 1.6e-108, 98.8% id in 251 aa. Possible gene remnant; autolysin complement(2128998..2129753) Staphylococcus aureus subsp. aureus MRSA252 2861487 YP_041412.1 CDS SAR2041 NC_002952.2 2129765 2130019 R Similar to Staphylococcus aureus prophage phiPV83 holin TR:Q9MBN5 (EMBL:AB044554) (84 aa) fasta scores: E(): 3.8e-32, 98.81% id in 84 aa, and to bacteriophage TP901-1 Hol TR:Q9AZ53 (EMBL:AF304433) (88 aa) fasta scores: E(): 5.9e-11, 43.75% id in 80 aa; holin complement(2129765..2130019) Staphylococcus aureus subsp. aureus MRSA252 2861488 YP_041413.1 CDS SAR2042 NC_002952.2 2130231 2130416 R No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein complement(2130231..2130416) Staphylococcus aureus subsp. aureus MRSA252 2861489 YP_041414.1 CDS SAR2043 NC_002952.2 2130516 2131289 R Similar to Staphylococcus aureus enterotoxin type A precursor EntA SW:ETXA_STAAU (P13163) (257 aa) fasta scores: E(): 1.7e-98, 98.05% id in 257 aa, and to Staphylococcus aureus enterotoxin type E precursor EntE SW:ETXE_STAAU (P12993) (257 aa) fasta scores: E(): 1.2e-82, 82.87% id in 257 aa; enterotoxin type A precursor complement(2130516..2131289) Staphylococcus aureus subsp. aureus MRSA252 2861490 YP_041415.1 CDS SAR2044 NC_002952.2 2131407 2131601 R Doubtful CDS. No significant database hits; hypothetical protein complement(2131407..2131601) Staphylococcus aureus subsp. aureus MRSA252 2861491 YP_041416.1 CDS SAR2045 NC_002952.2 2131710 2132084 R Poor database matches. Similar to the C-terminal region of Borrelia hermsii hypothetical protein BdrC1 TR:Q9RG81 (EMBL:AF143476) (238 aa) fasta scores: E(): 3, 24.4% id in 127 aa; hypothetical protein complement(2131710..2132084) Staphylococcus aureus subsp. aureus MRSA252 2861492 YP_041417.1 CDS SAR2046 NC_002952.2 2132140 2132427 R Identical to bacteriophage phi PVL hypothetical protein Orf 22 TR:O80061 (EMBL:AB009866) (95 aa) fasta scores: E(): 2.6e-31, 100% id in 95 aa. Similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf 22 homologue TR:Q9MBN7 (EMBL:AB044554) (95 aa) fasta scores: E(): 2.1e-28, 91.57% id in 95 aa; hypothetical protein complement(2132140..2132427) Staphylococcus aureus subsp. aureus MRSA252 2861493 YP_041418.1 CDS SAR2047 NC_002952.2 2132474 2132626 R Identical to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 55 TR:Q9MBN8 (EMBL:AB044554) (50 aa) fasta scores: E(): 2e-19, 100% id in 50 aa; hypothetical protein complement(2132474..2132626) Staphylococcus aureus subsp. aureus MRSA252 2861494 YP_041419.1 CDS SAR2048 NC_002952.2 2132616 2136401 R Similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf 20 and 21 homologues TR:Q9MBN9 (EMBL:AB044554) (1261 aa) fasta scores: E(): 0, 97.78% id in 1261 aa. N-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 20 TR:O80059 (EMBL:AB009866) (759 aa) fasta scores: E(): 0, 99.46% id in 752 aa. C-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 21 TR:O80060 (EMBL:AB009866) (418 aa) fasta scores: E(): 5.2e-131, 99.76% id in 418 aa. Contains coiled-coiled domain, residues 714 to 735; hypothetical protein complement(2132616..2136401) Staphylococcus aureus subsp. aureus MRSA252 2861495 YP_041420.1 CDS SAR2049 NC_002952.2 2136417 2137901 R Similar to Staphylococcus aureus prophage phiPV83 phi PVL Orf 18 and 19 homologues TR:Q9MBP0 (EMBL:AB044554) (496 aa) fasta scores: E(): 1.4e-180, 88.91% id in 496 aa. N-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 18 TR:O80057 (EMBL:AB009866) (119 aa) fasta scores: E(): 3.7e-23, 60.52% id in 114 aa. C-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 19 TR:O80058 (EMBL:AB009866) (377 aa) fasta scores: E(): 3.7e-152, 99.46% id in 377 aa; hypothetical protein complement(2136417..2137901) Staphylococcus aureus subsp. aureus MRSA252 2861496 YP_041421.1 CDS SAR2050 NC_002952.2 2137898 2142427 R No significant database matches to the full length CDS. N-terminal region is similar to similar to bacteriophage phi PVL hypothetical protein Orf 15 TR:O80054 (EMBL:AB009866) (694 aa) fasta scores: E(): 5.7e-22, 28.4% id in 704 aa. Internal region is similar to bacteriophage phi PVL hypothetical protein Orf 16 TR:O80055 (EMBL:AB009866) (539 aa) fasta scores: E(): 2.2e-150, 82.97% id in 517 aa. C-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 17 TR:O80056 (EMBL:AB009866) (223 aa) fasta scores: E(): 2.5e-36, 55.55% id in 225 aa; hypothetical protein complement(2137898..2142427) Staphylococcus aureus subsp. aureus MRSA252 2861497 YP_041422.1 CDS SAR2051 NC_002952.2 2142484 2142645 R No significant database matches. Possible alternative translational start sites; hypothetical protein complement(2142484..2142645) Staphylococcus aureus subsp. aureus MRSA252 2861498 YP_041423.1 CDS SAR2052 NC_002952.2 2142672 2143022 R Poor database matches. C-terminus is similar to the C-terminal regions of bacteriophage phi PVL hypothetical protein Orf 14 TR:O80053 (EMBL:AB009866) (148 aa) fasta scores: E(): 2.4, 28.76% id in 73 aa, and to Staphylococcus aureus prophage phiPV83 phi PVL Orf 14 homologue TR:Q9MBP3 (EMBL:AB044554) (148 aa) fasta scores: E(): 1.3, 28.76% id in 73 aa; hypothetical protein complement(2142672..2143022) Staphylococcus aureus subsp. aureus MRSA252 2861499 YP_041424.1 CDS SAR2053 NC_002952.2 2143072 >2143353 R Similar to bacteriophage A118 gp13 TR:Q9T1B0 (EMBL:AJ242593) (110 aa) fasta scores: E(): 0.36, 28.23% id in 85 aa, and to the C-terminal region of bacteriophage phi PVL hypothetical protein Orf 13 TR:O80052 (EMBL:AB009866) (317 aa) fasta scores: E(): 0.00058, 38.09% id in 84 aa; hypothetical protein complement(2143072..>2143353) Staphylococcus aureus subsp. aureus MRSA252 2861500 YP_041425.1 CDS SAR2054 NC_002952.2 2143338 2143982 R Poor database matches. Similar to the N-terminal region of bacteriophage phi PVL hypothetical protein Orf 13 TR:O80052 (EMBL:AB009866) (317 aa) fasta scores: E(): 0.12, 23.83% id in 193 aa; hypothetical protein complement(2143338..2143982) Staphylococcus aureus subsp. aureus MRSA252 2861501 YP_041426.1 CDS SAR2055 NC_002952.2 2143983 2144390 R Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf131b TR:Q9B0D6 (EMBL:AB045978) (131 aa) fasta scores: E(): 0.015, 28.46% id in 137 aa; hypothetical protein complement(2143983..2144390) Staphylococcus aureus subsp. aureus MRSA252 2861502 YP_041427.1 CDS SAR2058 NC_002952.2 2144787 2145149 R Similar to bacteriophage phi PVL hypothetical protein Orf 10 TR:O80049 (EMBL:AB009866) (111 aa) fasta scores: E(): 3.8e-06, 30.27% id in 109 aa, and to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf110 TR:Q9B0D8 (EMBL:AB045978) (110 aa) fasta scores: E(): 0.00034, 26% id in 100 aa; hypothetical protein complement(2144787..2145149) Staphylococcus aureus subsp. aureus MRSA252 2861504 YP_041428.1 CDS SAR2059 NC_002952.2 2145133 2145417 R hypothetical protein complement(2145133..2145417) Staphylococcus aureus subsp. aureus MRSA252 2861505 YP_041429.1 CDS SAR2060 NC_002952.2 2145407 2145691 R Similar to Bacillus halodurans hypothetical protein BH3526 TR:Q9K747 (EMBL:AP001519) (80 aa) fasta scores: E(): 0.03, 32.92% id in 82 aa, and to bacteriophage phi ETA hypothetical protein Orf45 TR:Q9G000 (EMBL:AP001553) (108 aa) fasta scores: E(): 0.67, 26.66% id in 105 aa; hypothetical protein complement(2145407..2145691) Staphylococcus aureus subsp. aureus MRSA252 2861506 YP_041430.1 CDS SAR2061 NC_002952.2 2145711 2146856 R hypothetical protein complement(2145711..2146856) Staphylococcus aureus subsp. aureus MRSA252 2861507 YP_041431.1 CDS SAR2062 NC_002952.2 2146880 2147617 R Similar to Streptococcus thermophilus bacteriophage DT1 scaffolding protein TR:Q9XJA0 (EMBL:AF085222) (222 aa) fasta scores: E(): 6.5e-25, 43.33% id in 210 aa, and to Streptococcus thermophilus bacteriophage Sfi21 clp-protease Orf221 TR:Q9XJ78 (EMBL:AF115103) (224 aa) fasta scores: E(): 1.8e-23, 40.48% id in 205 aa; Clp protease complement(2146880..2147617) Staphylococcus aureus subsp. aureus MRSA252 2861508 YP_041432.1 CDS SAR2063 NC_002952.2 2147601 2148788 R Similar to bacteriophage bIL285 portal protein Orf42 TR:Q9AZY7 (EMBL:AF323668) (413 aa) fasta scores: E(): 0.0016, 23.96% id in 388 aa, and to bacteriophage phi-105 hypothetical protein Orf25 TR:Q9ZXF8 (EMBL:AB016282) (416 aa) fasta scores: E(): 0.027, 22.08% id in 403 aa; hypothetical protein complement(2147601..2148788) Staphylococcus aureus subsp. aureus MRSA252 2861509 YP_041433.1 CDS SAR2064 NC_002952.2 2148804 2150465 R Similar to Staphylococcus aureus temperate phage phiSLT terminase large subunit TR:Q9B0E3 (EMBL:AB045978) (563 aa) fasta scores: E(): 1.7e-27, 27.55% id in 548 aa, and to bacteriophage phi PVL hypothetical protein Orf 2 TR:O80041 (EMBL:AB009866) (564 aa) fasta scores: E(): 4.1e-19, 22.6% id in 553 aa; hypothetical protein complement(2148804..2150465) Staphylococcus aureus subsp. aureus MRSA252 2861510 YP_041434.1 CDS SAR2065 NC_002952.2 2150462 2150806 R hypothetical protein complement(2150462..2150806) Staphylococcus aureus subsp. aureus MRSA252 2861511 YP_041435.1 CDS SAR2065a NC_002952.2 2150829 2150942 R hypothetical protein complement(2150829..2150942) Staphylococcus aureus subsp. aureus MRSA252 2861512 YP_041436.1 CDS SAR2066 NC_002952.2 2150936 2151235 R Similar to the C-terminal regions of Streptococcus thermophilus bacteriophage Sfi21 hypothetical protein TR:Q9XJW4 (EMBL:AF112470) (175 aa) fasta scores: E(): 4e-06, 38.37% id in 86 aa, and bacteriophage bIL285 hypothetical protein Orf39 TR:Q9AZZ0 (EMBL:AF323668) (150 aa) fasta scores: E(): 4.7e-06, 42.1% id in 76 aa; hypothetical protein complement(2150936..2151235) Staphylococcus aureus subsp. aureus MRSA252 2861513 YP_041437.1 CDS SAR2067 NC_002952.2 2151467 2151883 R Similar to bacteriophage r1t hypothetical protein Orf25 TR:Q38111 (EMBL:U38906) (143 aa) fasta scores: E(): 0.0027, 26.35% id in 129 aa, and to Lactococcus bacteriophage phi31 transcriptional activator of phage 31 late promoter TR:O64272 (EMBL:AF022773) (143 aa) fasta scores: E(): 0.0027, 26.35% id in 129 aa; hypothetical protein complement(2151467..2151883) Staphylococcus aureus subsp. aureus MRSA252 2861514 YP_041438.1 CDS SAR2068 NC_002952.2 2151911 2152114 R Similar to bacteriophage phi PVL hypothetical protein Orf 60 TR:O80098 (EMBL:AB009866) (67 aa) fasta scores: E(): 7.2e-24, 95.52% id in 67 aa, and to Staphylococcus aureus prophage phiPV83 phi PVL orf 60 homologue TR:Q9MBQ6 (EMBL:AB044554) (66 aa) fasta scores: E(): 1.6e-24, 100% id in 66 aa; hypothetical protein complement(2151911..2152114) Staphylococcus aureus subsp. aureus MRSA252 2861515 YP_041439.1 CDS SAR2069 NC_002952.2 2152111 2152260 R Similar to bacteriophage phi PVL hypothetical protein Orf 57 TR:O80095 (EMBL:AB009866) (54 aa) fasta scores: E(): 3.9e-19, 93.87% id in 49 aa, and to Staphylococcus aureus prophage phiPV83 phi PVL Orf 57 / phi 11 RinB homologue TR:Q9MBQ7 (EMBL:AB044554) (49 aa) fasta scores: E(): 4.4e-19, 95.91% id in 49 aa. Similar to SAR1527, 87.755% identity (89.583% ungapped) in 49 aa overlap; hypothetical protein complement(2152111..2152260) Staphylococcus aureus subsp. aureus MRSA252 2861516 YP_041440.1 CDS SAR2070 NC_002952.2 2152257 2152643 R Identical to bacteriophage phi ETA hypothetical protein Orf36 TR:Q9G009 (EMBL:AP001553) (128 aa) fasta scores: E(): 4.5e-45, 100% id in 128 aa. Similar to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf31 TR:Q9MBQ8 (EMBL:AB044554) (130 aa) fasta scores: E(): 2.2e-40, 91.33% id in 127 aa; hypothetical protein complement(2152257..2152643) Staphylococcus aureus subsp. aureus MRSA252 2861517 YP_041441.1 CDS SAR2071 NC_002952.2 2152640 2152846 R Similar to bacteriophage phi ETA hypothetical protein Orf35 TR:Q9G010 (EMBL:AP001553) (68 aa) fasta scores: E(): 2.7e-23, 98.52% id in 68 aa, and to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf77 TR:Q9B0F0 (EMBL:AB045978) (77 aa) fasta scores: E(): 1.4e-12, 95.55% id in 45 aa. Similar to SAR1529, 78.723% identity (78.723% ungapped) in 47 aa overlap; hypothetical protein complement(2152640..2152846) Staphylococcus aureus subsp. aureus MRSA252 2861518 YP_041442.1 CDS SAR2072 NC_002952.2 2152883 2153425 R Similar to bacteriophage phi PVL dUTP pyrophosphatase (dUTPase) TR:O80091 (EMBL:AB009866) (175 aa) fasta scores: E(): 2.5e-30, 78.26% id in 184 aa, and to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 53 homologue TR:Q9B0F2 (EMBL:AB045978) (175 aa) fasta scores: E(): 1.2e-46, 77.17% id in 184 aa; dUTP pyrophosphatase complement(2152883..2153425) Staphylococcus aureus subsp. aureus MRSA252 2861519 YP_041443.1 CDS SAR2073 NC_002952.2 2153418 2153600 R hypothetical protein complement(2153418..2153600) Staphylococcus aureus subsp. aureus MRSA252 2861520 YP_041444.1 CDS SAR2074 NC_002952.2 2153590 2153841 R Similar to bacteriophage phi ETA hypothetical protein Orf32 TR:Q9G013 (EMBL:AP001553) (80 aa) fasta scores: E(): 5.8e-25, 95% id in 80 aa, and to bacteriophage phi PVL hypothetical protein Orf 52 TR:O80090 (EMBL:AB009866) (82 aa) fasta scores: E(): 9.7e-23, 85.36% id in 82 aa. Similar to SAR1532, 82.927% identity (82.927% ungapped) in 82 aa overlap; hypothetical protein complement(2153590..2153841) Staphylococcus aureus subsp. aureus MRSA252 2861521 YP_041445.1 CDS SAR2075 NC_002952.2 2153834 2154007 R Identical to the C-terminal region of bacteriophage phi ETA hypothetical protein Orf29 TR:Q9G016 (EMBL:AP001553) (139 aa) fasta scores: E(): 8.2e-23, 100% id in 56 aa. Possible C-terminal region of a pseudogene; hypothetical protein complement(2153834..2154007) Staphylococcus aureus subsp. aureus MRSA252 2861522 YP_041446.1 CDS SAR2076 NC_002952.2 2154013 2154255 R Similar to bacteriophage phi PVL hypothetical protein Orf 51 TR:O80089 (EMBL:AB009866) (80 aa) fasta scores: E(): 1.2e-29, 92.5% id in 80 aa. Similar to the N-terminus of bacteriophage phi ETA hypothetical protein Orf29 TR:Q9G016 (EMBL:AP001553) (139 aa) fasta scores: E(): 2e-21, 90.47% id in 63 aa. Possible N-terminal region of a pseudogene. Similar to SAR1536, 82.500% identity (82.500% ungapped) in 80 aa overlap; hypothetical protein complement(2154013..2154255) Staphylococcus aureus subsp. aureus MRSA252 2861523 YP_041447.1 CDS SAR2077 NC_002952.2 2154259 2154627 R Similar to bacteriophage phi PVL hypothetical protein Orf 50 TR:O80088 (EMBL:AB009866) (122 aa) fasta scores: E(): 5e-41, 97.54% id in 122 aa, and to Staphylococcus aureus temperate phage phiSLT phi PVL Orf 50 homologue TR:Q9B0F5 (EMBL:AB045978) (122 aa) fasta scores: E(): 1.2e-39, 92.62% id in 122 aa; hypothetical protein complement(2154259..2154627) Staphylococcus aureus subsp. aureus MRSA252 2861524 YP_041448.1 CDS SAR2080 NC_002952.2 2154958 2155176 R Similar to bacteriophage phi PVL hypothetical protein Orf 47 TR:O80086 (EMBL:AB009866) (72 aa) fasta scores: E(): 1.2e-29, 98.61% id in 72 aa; hypothetical protein complement(2154958..2155176) Staphylococcus aureus subsp. aureus MRSA252 2860092 YP_041449.1 CDS SAR2083 NC_002952.2 2156086 2156556 R Similar to bacteriophage phi PVL single-strand DNA-binding protein TR:O80084 (EMBL:AB009866) (156 aa) fasta scores: E(): 1.9e-55, 96.15% id in 156 aa, and to bacteriophage A118 ssDNA binding protein Ssb TR:Q9T160 (EMBL:AJ242593) (160 aa) fasta scores: E(): 6.2e-31, 56.87% id in 160 aa. Similar to SAR0363, 68.862% identity (73.718% ungapped) in 167 aa overlap; single-strand DNA-binding protein complement(2156086..2156556) Staphylococcus aureus subsp. aureus MRSA252 2860094 YP_041450.1 CDS SAR2084 NC_002952.2 2156557 2157042 R Similar to bacteriophage phi PVL hypothetical protein Orf 44 TR:O80083 (EMBL:AB009866) (161 aa) fasta scores: E(): 2.1e-60, 97.51% id in 161 aa; hypothetical protein complement(2156557..2157042) Staphylococcus aureus subsp. aureus MRSA252 2860095 YP_041451.1 CDS SAR2085 NC_002952.2 2157255 2158175 R Similar to bacteriophage phi PVL hypothetical protein Orf 43 TR:O80082 (EMBL:AB009866) (306 aa) fasta scores: E(): 7.5e-105, 99.67% id in 306 aa, and to Legionella pneumophila hypothetical protein TR:Q9AKZ0 (EMBL:AJ277755) (294 aa) fasta scores: E(): 0.36, 23.85% id in 306 aa; hypothetical protein complement(2157255..2158175) Staphylococcus aureus subsp. aureus MRSA252 2860096 YP_041452.1 CDS SAR2086 NC_002952.2 2158177 2160120 R Similar to N-terminal region of Thermoplasma volcanium purine NTPase TVG0235331 TR:BAB59370 (EMBL:AP000991) (895 aa) fasta scores: E(): 1.9e-05, 22.72% id in 691 aa. C-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 41 TR:O80080 (EMBL:AB009866) (332 aa) fasta scores: E(): 2.1e-85, 98.11% id in 318 aa. N-terminal region is similar to bacteriophage phi PVL hypothetical protein Orf 42 TR:O80081 (EMBL:AB009866) (273 aa) fasta scores: E(): 2.2e-69, 98.16% id in 273 aa; hypothetical protein complement(2158177..2160120) Staphylococcus aureus subsp. aureus MRSA252 2860097 YP_041453.1 CDS SAR2087 NC_002952.2 2160129 2160407 R Similar to bacteriophage phi PVL hypothetical protein Orf 40 TR:O80079 (EMBL:AB009866) (92 aa) fasta scores: E(): 2e-34, 98.91% id in 92 aa; hypothetical protein complement(2160129..2160407) Staphylococcus aureus subsp. aureus MRSA252 2860098 YP_041454.1 CDS SAR2088 NC_002952.2 2160401 2160661 R Similar to bacteriophage phi PVL hypothetical protein Orf 39 TR:O80078 (EMBL:AB009866) (86 aa) fasta scores: E(): 2.6e-13, 51.16% id in 86 aa, and to bacteriophage phi ETA hypothetical protein Orf15 TR:Q9G030 (EMBL:AP001553) (86 aa) fasta scores: E(): 6.8e-13, 48.83% id in 86 aa; hypothetical protein complement(2160401..2160661) Staphylococcus aureus subsp. aureus MRSA252 2860099 YP_041455.1 CDS SAR2089 NC_002952.2 2160642 2160968 R Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf100a TR:Q9B0G6 (EMBL:AB045978) (100 aa) fasta scores: E(): 1.9e-17, 52% id in 100 aa; hypothetical protein complement(2160642..2160968) Staphylococcus aureus subsp. aureus MRSA252 2860100 YP_041456.1 CDS SAR2090 NC_002952.2 2160965 2161066 R No significant database matches. Doubtful CDS, poor translational start site; hypothetical protein complement(2160965..2161066) Staphylococcus aureus subsp. aureus MRSA252 2860101 YP_041457.1 CDS SAR2091 NC_002952.2 2161063 2161224 R Similar to bacteriophage phi ETA hypothetical protein Orf14 TR:Q9G031 (EMBL:AP001553) (53 aa) fasta scores: E(): 2.2e-18, 94.34% id in 53 aa, and to bacteriophage phi PVL hypothetical protein Orf 38 TR:O80077 (EMBL:AB009866) (53 aa) fasta scores: E(): 7.7e-18, 92.45% id in 53 aa. Similar to SAR1546, 92.453% identity (92.453% ungapped) in 53 aa overlap; hypothetical protein complement(2161063..2161224) Staphylococcus aureus subsp. aureus MRSA252 2860102 YP_041458.1 CDS SAR2092 NC_002952.2 2161221 2161541 R Similar to Lactococcus lactis prophage pi1 protein 09 TR:Q9CIC0 (EMBL:AE006281) (109 aa) fasta scores: E(): 0.003, 32.99% id in 97 aa, and to bacteriophage bIL309 hypothetical protein Orf9 TR:Q9AZQ3 (EMBL:AF323670) (109 aa) fasta scores: E(): 0.003, 32.99% id in 97 aa; hypothetical protein complement(2161221..2161541) Staphylococcus aureus subsp. aureus MRSA252 2860103 YP_041459.1 CDS SAR2093 NC_002952.2 2161597 2162232 D Poor database matches. C-terminus is similar to the C-terminal region of bacteriophage phi ETA hypothetical protein Orf12 TR:Q9G033 (EMBL:AP001553) (221 aa) fasta scores: E(): 0.014, 25% id in 124 aa; hypothetical protein 2161597..2162232 Staphylococcus aureus subsp. aureus MRSA252 2860104 YP_041460.1 CDS SAR2094 NC_002952.2 2162247 2162387 R Similar to Staphylococcus aureus prophage phiPV83 hypothetical protein Orf 8 TR:Q9MBT1 (EMBL:AB044554) (46 aa) fasta scores: E(): 3.2e-16, 95.65% id in 46 aa; hypothetical protein complement(2162247..2162387) Staphylococcus aureus subsp. aureus MRSA252 2860105 YP_041461.1 CDS SAR2095 NC_002952.2 2162418 2162615 R Similar to bacteriophage phi PVL hypothetical protein Orf 35 TR:O80075 (EMBL:AB009866) (65 aa) fasta scores: E(): 8.1e-25, 95.38% id in 65 aa. Similar to SAR1552, 67.692% identity (67.692% ungapped) in 65 aa overlap; hypothetical protein complement(2162418..2162615) Staphylococcus aureus subsp. aureus MRSA252 2860106 YP_041462.1 CDS SAR2096 NC_002952.2 2162631 2163383 R Similar to bacteriophage phi PVL anti repressor TR:O80074 (EMBL:AB009866) (249 aa) fasta scores: E(): 1.3e-70, 80.95% id in 252 aa, and to bacteriophage phi ETA hypothetical protein Orf11 TR:Q9G034 (EMBL:AP001553) (250 aa) fasta scores: E(): 1.6e-80, 89.6% id in 250 aa; anti repressor complement(2162631..2163383) Staphylococcus aureus subsp. aureus MRSA252 2860107 YP_041463.1 CDS SAR2097 NC_002952.2 2163434 2163763 D Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf121 TR:Q9B0H0 (EMBL:AB045978) (121 aa) fasta scores: E(): 0.0053, 24.07% id in 108 aa; hypothetical protein 2163434..2163763 Staphylococcus aureus subsp. aureus MRSA252 2860108 YP_041464.1 CDS SAR2098 NC_002952.2 2163752 2163967 R Poor database matches. Similar to N-terminal region of Schizosaccharomyces pombe 60S ribosomal protein L43 RPL43 SW:RL43_SCHPO (O94686) (94 aa) fasta scores: E(): 5.5, 37.5% id in 56 aa; hypothetical protein complement(2163752..2163967) Staphylococcus aureus subsp. aureus MRSA252 2860109 YP_041465.1 CDS SAR2099 NC_002952.2 2163983 2164246 R Similar to bacteriophage A118 repressor protein TR:Q9T188 (EMBL:AJ242593) (101 aa) fasta scores: E(): 0.096, 37.87% id in 66 aa, and to Pyrococcus abyssi repressor protein PAB7155 TR:Q9V101 (EMBL:AJ248284) (73 aa) fasta scores: E(): 0.047, 39.06% id in 64 aa; DNA-binding protein complement(2163983..2164246) Staphylococcus aureus subsp. aureus MRSA252 2860110 YP_041466.1 CDS SAR2100 NC_002952.2 2164379 2165092 D Similar to bacteriophage phi ETA bacteriophage phi ETA repressor TR:Q9G039 (EMBL:AP001553) (238 aa) fasta scores: E(): 6.1e-57, 72.29% id in 231 aa, and to Staphylococcus aureus prophage phiPV83 repressor TR:Q9MBT4 (EMBL:AB044554) (236 aa) fasta scores: E(): 1.2e-42, 55.17% id in 232 aa; repressor 2164379..2165092 Staphylococcus aureus subsp. aureus MRSA252 2860111 YP_041467.1 CDS SAR2101 NC_002952.2 2165108 2166040 D Similar to Caulobacter crescentus exonuclease CC1523 TR:Q9A841 (EMBL:AE005827) (202 aa) fasta scores: E(): 1.6e-13, 30.57% id in 193 aa, and to Chlamydia pneumoniae DNA polymerase III epsilon chain CP0344 TR:Q9Z8D3 (EMBL:AE001624) (237 aa) fasta scores: E(): 1.2e-05, 25.5% id in 200 aa; exonuclease 2165108..2166040 Staphylococcus aureus subsp. aureus MRSA252 2860112 YP_041468.1 CDS SAR2102 NC_002952.2 2166046 2166387 D hypothetical protein 2166046..2166387 Staphylococcus aureus subsp. aureus MRSA252 2860113 YP_041469.1 CDS SAR2103 NC_002952.2 2166570 2166773 D hypothetical protein 2166570..2166773 Staphylococcus aureus subsp. aureus MRSA252 2860114 YP_041470.1 CDS SAR2104 NC_002952.2 2166873 2167337 D Poor database matches. Similar to Staphylococcus aureus temperate phage phiSLT hypothetical protein Orf144 TR:Q9B0H6 (EMBL:AB045978) (144 aa) fasta scores: E(): 0.0021, 31.61% id in 136 aa; lipoprotein 2166873..2167337 Staphylococcus aureus subsp. aureus MRSA252 2860115 YP_041471.1 CDS int NC_002952.2 2167396 2168433 D Similar to Staphylococcus aureus bacteriophage phi-42 integrase Int TR:Q38086 (EMBL:U01872) (345 aa) fasta scores: E(): 2.3e-125, 99.13% id in 345 aa, and to bacteriophage phi-13 integrase Int TR:Q38460 (EMBL:X82312) (345 aa) fasta scores: E(): 9.1e-125, 98.55% id in 345 aa; integrase 2167396..2168433 Staphylococcus aureus subsp. aureus MRSA252 2859670 YP_041472.1 CDS SAR2107 NC_002952.2 2169572 2170591 R Similar to Staphylococcus aureus leukocidin F subunit precursor LukF SW:LUKF_STAAU (P31715) (323 aa) fasta scores: E(): 2.5e-34, 40.97% id in 327 aa, and to Staphylococcus aureus prophage phiPV83 leukocidin F precursor LukF-PV TR:Q9MBN2 (EMBL:AB044554) (322 aa) fasta scores: E(): 4.2e-40, 39.45% id in 327 aa; leukocidin F subunit complement(2169572..2170591) Staphylococcus aureus subsp. aureus MRSA252 2860116 YP_041473.1 CDS SAR2108 NC_002952.2 2170613 2171668 R Similar to Staphylococcus aureus leukocidin S subunit precursor LukS SW:LUKS_STAAU (P31716) (315 aa) fasta scores: E(): 1.8e-25, 33.44% id in 290 aa, and to bacteriophage phi PVL leukocidin S component LukS-PV TR:O80066 (EMBL:AB009866) (312 aa) fasta scores: E(): 6.1e-27, 34.64% id in 280 aa; leukocidin S subunit complement(2170613..2171668) Staphylococcus aureus subsp. aureus MRSA252 2860117 YP_041474.1 CDS SAR2109 NC_002952.2 2172100 2173323 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2172100..2173323 Staphylococcus aureus subsp. aureus MRSA252 2860118 YP_041475.1 CDS SAR2111 NC_002952.2 2173762 2175069 D Similar to Bacillus subtilis YubG TR:O32081 (EMBL:Z99119) (445 aa) fasta scores: E(): 1.1e-58, 43.02% id in 423 aa, and to Aquifex aeolicus K+ transport protein homologue AQ_1504 TR:O67474 (EMBL:AE000743) (443 aa) fasta scores: E(): 3.4e-54, 38.82% id in 443 aa; sodium transport protein 2173762..2175069 Staphylococcus aureus subsp. aureus MRSA252 2860119 YP_041476.1 CDS SAR2113 NC_002952.2 2175647 2175988 R Doubtful CDS, poor translational start site. No significant database matches; hypothetical protein complement(2175647..2175988) Staphylococcus aureus subsp. aureus MRSA252 2860121 YP_041477.1 CDS SAR2114 NC_002952.2 2175978 2176274 R Doubtful CDS, poor translational start site. No significant database matches; hypothetical protein complement(2175978..2176274) Staphylococcus aureus subsp. aureus MRSA252 2860122 YP_041478.1 CDS SAR2115 NC_002952.2 2176271 2176459 R Poor database matches. Similar to the N-terminal region of Mycoplasma capricolum DNA repair protein RecM TR:Q49026 (EMBL:Z33128) (107 aa) fasta scores: E(): 9.9, 30.18% id in 53 aa; hypothetical protein complement(2176271..2176459) Staphylococcus aureus subsp. aureus MRSA252 2860123 YP_041479.1 CDS groEL NC_002952.2 2176992 2178608 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(2176992..2178608) Staphylococcus aureus subsp. aureus MRSA252 2859943 YP_041480.1 CDS groES NC_002952.2 2178684 2178968 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(2178684..2178968) Staphylococcus aureus subsp. aureus MRSA252 2859944 YP_041481.1 CDS SAR2118 NC_002952.2 2179143 2179886 D Similar to Bacillus subtilis hypothetical protein YdiL TR:O05525 (EMBL:D88802) (244 aa) fasta scores: E(): 2.4e-18, 33.33% id in 240 aa, and to Bacillus halodurans hypothetical protein BH0560 TR:Q9KFC4 (EMBL:AP001508) (237 aa) fasta scores: E(): 1.8e-16, 32.74% id in 226 aa; hypothetical protein 2179143..2179886 Staphylococcus aureus subsp. aureus MRSA252 2860124 YP_041482.1 CDS SAR2119 NC_002952.2 2179911 2181125 R Poor database matches. Similar to Staphylococcus epidermidis cell-surface-associated protein SdrH TR:Q9KI12 (EMBL:AF245043) (487 aa) fasta scores: E(): 1.1e-20, 32.51% id in 366 aa. Contains a proline rich region, residues 106 to 182; membrane anchored protein complement(2179911..2181125) Staphylococcus aureus subsp. aureus MRSA252 2860125 YP_041483.1 CDS SAR2120 NC_002952.2 2181322 2181948 D Similar to Neisseria meningitidis (serogroup A) hypothetical protein NMA2195 TR:Q9JQW5 (EMBL:AL162758) (201 aa) fasta scores: E(): 1.6e-34, 49.74% id in 195 aa, and to Pseudomonas aeruginosa hypothetical protein PA2575 TR:Q9I0R1 (EMBL:AE004686) (200 aa) fasta scores: E(): 4.4e-32, 46.9% id in 194 aa; hypothetical protein 2181322..2181948 Staphylococcus aureus subsp. aureus MRSA252 2860126 YP_041484.1 CDS SAR2121 NC_002952.2 2182309 2183094 D Previously sequenced as Staphylococcus aureus hypothetical protein in agr operon SW:YAG5_STAAU (P55177) (261 aa) fasta scores: E(): 3.9e-101, 98.85% id in 261 aa. Similar to Staphylococcus epidermidis hypothetical protein TR:O68163 (EMBL:AF012132) (264 aa) fasta scores: E(): 3.5e-61, 61.3% id in 261 aa; carbon-nitrogen hydrolase 2182309..2183094 Staphylococcus aureus subsp. aureus MRSA252 2860541 YP_041485.1 CDS hld NC_002952.2 2183697 2183834 R Lyses erythrocytes and other mammalian cells; delta-hemolysin complement(2183697..2183834) Staphylococcus aureus subsp. aureus MRSA252 2861641 YP_041486.1 CDS agrB NC_002952.2 2184067 2184630 D Signal generating component of the agr autoinducer peptide-quorum sensing system. Similar to Staphylococcus aureus probable autoinducer processing protein, accessory gene regulator protein B, AgrB SW:AGRB_STAAU (P21545) (189 aa) fasta scores: E(): 8.9e-56, 77.54% id in 187 aa, and to Staphylococcus epidermidis accessory gene regulator protein AgrB TR:O86859 (EMBL:Z49220) (194 aa) fasta scores: E(): 9.9e-36, 51.87% id in 187 aa; autoinducer processing protein 2184067..2184630 Staphylococcus aureus subsp. aureus MRSA252 2860982 YP_041487.1 CDS agrD NC_002952.2 2184634 2184774 D Signal generating component of the agr autoinducer peptide-quorum sensing system. Similar to Staphylococcus aureus group III autoinducer peptide precursor AgrD TR:O33589 (EMBL:AF001783) (46 aa) fasta scores: E(): 6.7e-19, 100% id in 46 aa. Similar to Staphylococcus aureus group IV autoinducer peptide precursor AgrD TR:Q9L561 (EMBL:AF255950) (46 aa) fasta scores: E(): 1.7e-06, 47.82% id in 46 aa; autoinducer peptide 2184634..2184774 Staphylococcus aureus subsp. aureus MRSA252 2860984 YP_041488.1 CDS agrC NC_002952.2 2184799 2186091 D Signal dectecting component of the agr autoinducer peptide-quorum sensing system. Two-component regulatory system family, sensor kinase. Similar to Staphylococcus aureus accessory gene regulator C AgrC TR:Q53644 (EMBL:X52543) (423 aa) fasta scores: E(): 1.7e-101, 75.23% id in 424 aa, and to Staphylococcus epidermidis histidine kinase AgrC TR:O68159 (EMBL:AF012132) (429 aa) fasta scores: E(): 6.3e-76, 54.93% id in 426 aa; autoinducer sensor protein 2184799..2186091 Staphylococcus aureus subsp. aureus MRSA252 2860983 YP_041489.1 CDS agrA NC_002952.2 2186110 2186826 D Signal dectecting component of the agr autoinducer peptide-quorum sensing system. Two-component regulatory system family, response regulator protein. Identical to Staphylococcus aureus accessory gene regulator protein A AgrA SW:AGRA_STAAU (P13131) (238 aa) fasta scores: E(): 2.5e-94, 100% id in 238 aa. Similar to Staphylococcus epidermidis response regulator AgrA TR:O68158 (EMBL:AF012132) (238 aa) fasta scores: E(): 2.2e-84, 87.39% id in 238 aa; autoinducer sensor protein response regulator protein 2186110..2186826 Staphylococcus aureus subsp. aureus MRSA252 2860981 YP_041490.1 CDS SAR2127 NC_002952.2 2187200 2188159 R Similar to Lycopersicon esculentum fructokinase FRK2 TR:Q42896 (EMBL:U62329) (328 aa) fasta scores: E(): 2.5e-39, 39.49% id in 314 aa, and to Beta vulgaris fructokinase TR:Q42645 (EMBL:U37838) (331 aa) fasta scores: E(): 3.3e-39, 40.38% id in 312 aa; fructokinase complement(2187200..2188159) Staphylococcus aureus subsp. aureus MRSA252 2859373 YP_041491.1 CDS scrB NC_002952.2 2188156 2189640 R Similar to Staphylococcus xylosus sucrose-6-phosphate hydrolase ScrB SW:SCRB_STAXY (Q05936) (494 aa) fasta scores: E(): 9e-151, 70.12% id in 492 aa, and to Vibrio alginolyticus sucrose-6-phosphate hydrolase ScrB SW:SCRB_VIBAL (P13394) (484 aa) fasta scores: E(): 1.8e-65, 39.87% id in 469 aa; sucrose-6-phosphate hydrolase complement(2188156..2189640) Staphylococcus aureus subsp. aureus MRSA252 2859127 YP_041492.1 CDS scrR NC_002952.2 2189789 2190739 R Similar to Staphylococcus xylosus sucrose operon repressor ScrR SW:SCRR_STAXY (P74892) (320 aa) fasta scores: E(): 1.6e-67, 59.23% id in 314 aa, and to Bacillus halodurans transcriptional regulator BH1855 TR:Q9KBS0 (EMBL:AP001513) (326 aa) fasta scores: E(): 1.2e-38, 37.1% id in 318 aa; sucrose operon repressor complement(2189789..2190739) Staphylococcus aureus subsp. aureus MRSA252 2859128 YP_041493.1 CDS SAR2130 NC_002952.2 2190923 2192173 R Similar to Bacillus subtilis probable ammonium transporter NrgA SW:NRGA_BACSU (Q07429) (404 aa) fasta scores: E(): 2.8e-79, 51.49% id in 402 aa, and to Lactococcus lactis ammonium transporter AmtB TR:Q9CF89 (EMBL:AE006389) (413 aa) fasta scores: E(): 7.4e-60, 42.01% id in 407 aa; ammonium transporter family protein complement(2190923..2192173) Staphylococcus aureus subsp. aureus MRSA252 2859374 YP_041494.1 CDS SAR2131 NC_002952.2 2192382 2192606 R Similar to Escherichia coli hypothetical protein YeeD SW:YEED_ECOLI (P33014) (75 aa) fasta scores: E(): 3.3e-17, 63.01% id in 73 aa, and to Escherichia coli, hypothetical protein YedF SW:YEDF_ECOLI (P31065) (77 aa) fasta scores: E(): 0.00059, 32.39% id in 71 aa; hypothetical protein complement(2192382..2192606) Staphylococcus aureus subsp. aureus MRSA252 2859375 YP_041495.1 CDS SAR2132 NC_002952.2 2192666 2193745 R Similar to Escherichia coli hypothetical protein YeeE SW:YEEE_ECOLI (P33015) (352 aa) fasta scores: E(): 1.2e-78, 58.62% id in 348 aa, and to Thermotoga maritima conserved hypothetical protein YM0982 TR:Q9X077 (EMBL:AE001760) (332 aa) fasta scores: E(): 3.3e-28, 35.65% id in 345 aa; hypothetical protein complement(2192666..2193745) Staphylococcus aureus subsp. aureus MRSA252 2859376 YP_041496.1 CDS SAR2133 NC_002952.2 2194051 2194686 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(2194051..2194686) Staphylococcus aureus subsp. aureus MRSA252 2859377 YP_041497.1 CDS SAR2134 NC_002952.2 2194939 2196867 D Similar to Bacillus subtilis hypothetical ABC transporter ATP-binding protein YdiF SW:YDIF_BACSU (O05519) (642 aa) fasta scores: E(): 4.3e-84, 48.36% id in 641 aa, and to Bacillus halodurans ABC transporter BH0550 TR:Q9KFD1 (EMBL:AP001508) (642 aa) fasta scores: E(): 1.3e-80, 45.25% id in 643 aa; ABC transporter ATP-binding protein 2194939..2196867 Staphylococcus aureus subsp. aureus MRSA252 2859378 YP_041498.1 CDS SAR2135 NC_002952.2 2197235 2198845 D No significant database matches to the full length CDS. C-terminal region is similar to internal regions of Thermus aquaticus DNA mismatch repair protein MutS SW:MUTS_THEAQ (Q56215) (811 aa) fasta scores: E(): 6.8e-13, 25.96% id in 312 aa, and Streptococcus pyogenes DNA mismatch repair protein SPY2148 TR:Q99XL8 (EMBL:AE006633) (851 aa) fasta scores: E(): 1e-14, 28.83% id in 274 aa; hypothetical protein 2197235..2198845 Staphylococcus aureus subsp. aureus MRSA252 2859075 YP_041499.1 CDS SAR2136 NC_002952.2 2199159 2200184 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease complement(2199159..2200184) Staphylococcus aureus subsp. aureus MRSA252 2859076 YP_041500.1 CDS SAR2137 NC_002952.2 2200177 2200641 R Similar to Escherichia coli ribosomal-protein-alanine acetyltransferase RimI SW:RIMI_ECOLI (P09453) (148 aa) fasta scores: E(): 2e-07, 29.86% id in 144 aa, and to Bacillus subtilis hypothetical protein YdiD TR:O05517 (EMBL:D88802) (151 aa) fasta scores: E(): 6.2e-24, 45.69% id in 151 aa; acetyltransferase complement(2200177..2200641) Staphylococcus aureus subsp. aureus MRSA252 2859077 YP_041501.1 CDS SAR2138 NC_002952.2 2200614 2201276 R Similar to Bacillus subtilis hypothetical protein YdiC TR:O05516 (EMBL:D88802) (229 aa) fasta scores: E(): 2.6e-25, 43.91% id in 230 aa, and to Enterococcus faecalis hypothetical protein YdiC TR:O86212 (EMBL:Y17797) (204 aa) fasta scores: E(): 1.2e-23, 44.11% id in 204 aa. Possible alternative translational start site; hypothetical protein complement(2200614..2201276) Staphylococcus aureus subsp. aureus MRSA252 2859078 YP_041502.1 CDS SAR2139 NC_002952.2 2201257 2201751 R Similar to Bacillus halodurans hypothetical protein BH0545 TR:Q9KFD6 (EMBL:AP001508) (157 aa) fasta scores: E(): 7.7e-21, 47.82% id in 138 aa, and to Bacillus subtilis hypothetical protein YdiB SW:YDIB_BACSU (O05515) (158 aa) fasta scores: E(): 2.6e-18, 43.26% id in 141 aa; hypothetical protein complement(2201257..2201751) Staphylococcus aureus subsp. aureus MRSA252 2859079 YP_041503.1 CDS ilvD NC_002952.2 2202229 2203917 D catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 2202229..2203917 Staphylococcus aureus subsp. aureus MRSA252 2859665 YP_041504.1 CDS ilvB NC_002952.2 2203945 2205714 D Similar to Lactococcus lactis acetolactate synthase large subunit IlvB SW:ILVB_LACLA (Q02137) (575 aa) fasta scores: E(): 5e-115, 53.95% id in 556 aa, and to Bacillus subtilis acetolactate synthase large subunit IlvB SW:ILVB_BACSU (P37251) (573 aa) fasta scores: E(): 1.5e-119, 54.15% id in 554 aa; acetolactate synthase large subunit 2203945..2205714 Staphylococcus aureus subsp. aureus MRSA252 2859663 YP_041505.1 CDS ilvC NC_002952.2 2206105 2207109 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 2206105..2207109 Staphylococcus aureus subsp. aureus MRSA252 2859664 YP_041506.1 CDS leuA NC_002952.2 2207139 2208668 D catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 2207139..2208668 Staphylococcus aureus subsp. aureus MRSA252 2859698 YP_041507.1 CDS leuB NC_002952.2 2208671 2209717 D catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 2208671..2209717 Staphylococcus aureus subsp. aureus MRSA252 2859699 YP_041508.1 CDS leuC NC_002952.2 2209731 2211098 D dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 2209731..2211098 Staphylococcus aureus subsp. aureus MRSA252 2859700 YP_041509.1 CDS leuD NC_002952.2 2211099 2211671 D catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 2211099..2211671 Staphylococcus aureus subsp. aureus MRSA252 2859701 YP_041510.1 CDS ilvA NC_002952.2 2211686 2212954 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 2211686..2212954 Staphylococcus aureus subsp. aureus MRSA252 2859662 YP_041511.1 CDS SAR2149 NC_002952.2 2213031 2213447 R hypothetical protein complement(2213031..2213447) Staphylococcus aureus subsp. aureus MRSA252 2859080 YP_041512.1 CDS SAR2150 NC_002952.2 2219748 2220203 R Similar to Bacillus halodurans hypothetical protein BH0532 TR:Q9JWQ2 (EMBL:AP001508) (151 aa) fasta scores: E(): 3.5e-30, 53.06% id in 147 aa, and to Bacillus subtilis hypothetical protein YdcK TR:P96628 (EMBL:AB001488) (150 aa) fasta scores: E(): 2.1e-29, 50% id in 146 aa; hypothetical protein complement(2219748..2220203) Staphylococcus aureus subsp. aureus MRSA252 2859081 YP_041513.1 CDS SAR2151 NC_002952.2 2220196 2222346 R Similar to Bacillus halodurans hypotetical protein BH0531 TR:Q9KFE8 (EMBL:AP001508) (728 aa) fasta scores: E(): 8.4e-135, 55.29% id in 718 aa, and to Lactococcus lactis hypotetical protein YciC TR:Q9CIS1 (EMBL:AE006266) (712 aa) fasta scores: E(): 2.4e-123, 51.87% id in 719 aa; RNA binding protein complement(2220196..2222346) Staphylococcus aureus subsp. aureus MRSA252 2859082 YP_041514.1 CDS sigB NC_002952.2 2222781 2223551 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase; RNA polymerase sigma factor SigB complement(2222781..2223551) Staphylococcus aureus subsp. aureus MRSA252 2859143 YP_041515.1 CDS rsbW NC_002952.2 2223526 2224005 R binds to sigma-B preventing the formation of an RNA polymerase holoenzyme; serine-protein kinase RsbW complement(2223526..2224005) Staphylococcus aureus subsp. aureus MRSA252 2861460 YP_041516.1 CDS rsbV NC_002952.2 2224007 2224333 R Similar to Bacillus subtilis anti-sigma B factor antagonist RsbV SW:RSBV_BACSU (P17903) (109 aa) fasta scores: E(): 4.7e-14, 42.45% id in 106 aa. Previously sequenced as Staphylococcus aureus anti-sigma B factor antagonist RsbV SW:RSBV_STAAU (P95842) (108 aa) fasta scores: E(): 2.1e-39, 99.07% id in 108 aa; anti-sigma B factor antagonist complement(2224007..2224333) Staphylococcus aureus subsp. aureus MRSA252 2861459 YP_041517.1 CDS rsbU NC_002952.2 2224452 2225453 R Similar to Bacillus subtilis sigma factor SigB regulation protein, required for full glucose induction of sigma B-dependent genes, RsbU SW:RSBU_BACSU (P40399) (335 aa) fasta scores: E(): 1.5e-41, 38.85% id in 332 aa, and to Bacillus halodurans indirect positive regulator of sigma-B activity BH0526 TR:Q9KFF3 (EMBL:AP001508) (337 aa) fasta scores: E(): 5.1e-45, 39.58% id in 336 aa; sigma factor sigB regulation protein complement(2224452..2225453) Staphylococcus aureus subsp. aureus MRSA252 2861458 YP_041518.1 CDS SAR2156 NC_002952.2 2225802 2226164 R Similar to Escherichia coli protein responsible for the stable inheritance of plasmids during cell division, PemK SW:PEMK_ECOLI (P13976) (133 aa) fasta scores: E(): 0.019, 28.43% id in 102 aa, and to Staphylococcus epidermidis hypothetical protein TR:Q9F7V5 (EMBL:AF274004) (120 aa) fasta scores: E(): 3.3e-35, 90% id in 120 aa; hypothetical protein complement(2225802..2226164) Staphylococcus aureus subsp. aureus MRSA252 2859083 YP_041519.1 CDS SAR2157 NC_002952.2 2226161 2226331 R Similar to the C-terminal regions of Lactobacillus reuteri hypothetical protein TR:Q9FCV1 (EMBL:AJ278312) (82 aa) fasta scores: E(): 4.5, 33.84% id in 65 aa, and Bacillus subtilis hypothetical protein YdcD TR:P96621 (EMBL:AB001488) (93 aa) fasta scores: E(): 2.1, 40% id in 35 aa; hypothetical protein complement(2226161..2226331) Staphylococcus aureus subsp. aureus MRSA252 2859084 YP_041520.1 CDS alr NC_002952.2 2226416 2227564 R Similar to Bacillus stearothermophilus alanine racemase Alr SW:ALR_BACST (P10724) (388 aa) fasta scores: E(): 4.4e-53, 43.66% id in 371 aa. Previously sequenced as Staphylococcus aureus alanine racemase Alr SW:ALR_STAAU (Q9ZAH5) (382 aa) fasta scores: E(): 1e-147, 99.47% id in 382 aa; alanine racemase complement(2226416..2227564) Staphylococcus aureus subsp. aureus MRSA252 2860990 YP_041521.1 CDS acpS NC_002952.2 2227630 2227989 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(2227630..2227989) Staphylococcus aureus subsp. aureus MRSA252 2859058 YP_041522.1 CDS SAR2160 NC_002952.2 2227993 2228484 R Similar to Bacillus subtilis hypothetical protein YdbS TR:P96615 (EMBL:AB001488) (159 aa) fasta scores: E(): 1.2e-08, 30.98% id in 142 aa, and to Bacillus halodurans hypothetical protein BH1720 TR:Q9KC54 (EMBL:AP001512) (159 aa) fasta scores: E(): 3.6e-05, 25% id in 148 aa; hypothetical protein complement(2227993..2228484) Staphylococcus aureus subsp. aureus MRSA252 2859085 YP_041523.1 CDS SAR2161 NC_002952.2 2228477 2230054 R Similar to Bacillus subtilis hypothetical protein YdbT TR:P96616 (EMBL:AB001488) (493 aa) fasta scores: E(): 7.6e-12, 22.64% id in 530 aa, and to Bacillus halodurans hypothetical protein BH1721 TR:Q9KC53 (EMBL:AP001512) (496 aa) fasta scores: E(): 2e-08, 21.46% id in 531 aa; hypothetical protein complement(2228477..2230054) Staphylococcus aureus subsp. aureus MRSA252 2859086 YP_041524.1 CDS SAR2162 NC_002952.2 2230047 2230526 R Similar to Bacillus halodurans Bhypothetical protein H1720 TR:Q9KC54 (EMBL:AP001512) (159 aa) fasta scores: E(): 0.14, 23.3% id in 133 aa, and to Bacillus subtilis hypothetical protein YdbS TR:P96615 (EMBL:AB001488) (159 aa) fasta scores: E(): 0.3, 20.98% id in 162 aa; hypothetical protein complement(2230047..2230526) Staphylococcus aureus subsp. aureus MRSA252 2859087 YP_041525.1 CDS kdpC NC_002952.2 2230735 2231295 R one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C complement(2230735..2231295) Staphylococcus aureus subsp. aureus MRSA252 2859682 YP_041526.1 CDS kdpB NC_002952.2 2231315 2233342 R One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B complement(2231315..2233342) Staphylococcus aureus subsp. aureus MRSA252 2859681 YP_041527.1 CDS kdpA NC_002952.2 2233361 2235037 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(2233361..2235037) Staphylococcus aureus subsp. aureus MRSA252 2859680 YP_041528.1 CDS kdpD NC_002952.2 2235309 2237966 D Two-component regulatory system family, sensor kinase. Similar to Escherichia coli sensor for high-affinity potassium transport system KdpD SW:KDPD_ECOLI (P21865) (894 aa) fasta scores: E(): 4.1e-61, 26.59% id in 876 aa, and to Rhizobium loti two-component sensor MLL3127 TR:BAB50088 (EMBL:AP003001) (907 aa) fasta scores: E(): 2.4e-67, 27.54% id in 875 aa; sensor kinase 2235309..2237966 Staphylococcus aureus subsp. aureus MRSA252 2859683 YP_041529.1 CDS kdpE NC_002952.2 2237966 2238661 D Two-component regulatory system family, response regulator protein. Similar to Escherichia coli kdp operon transcriptional regulatory protein KdpE SW:KDPE_ECOLI (P21866) (225 aa) fasta scores: E(): 5.9e-26, 40.26% id in 226 aa, and to Clostridium acetobutylicum CAC3677 TR:P94609 (EMBL:U39673) (232 aa) fasta scores: E(): 1.1e-26, 39.11% id in 225 aa; response regulator protein 2237966..2238661 Staphylococcus aureus subsp. aureus MRSA252 2859685 YP_041530.1 CDS SAR2168 NC_002952.2 2239017 2240537 R Similar to the N-terminal region of Escherichia coli cold-shock DEAD-box protein A CsdA SW:DEAD_ECOLI (P23304) (628 aa) fasta scores: E(): 1.2e-55, 40.8% id in 473 aa, and to Bacillus subtilis ATP-dependent RNA helicase YdbR TR:P96614 (EMBL:AB001488) (511 aa) fasta scores: E(): 3.3e-79, 47.35% id in 492 aa; helicase complement(2239017..2240537) Staphylococcus aureus subsp. aureus MRSA252 2859088 YP_041531.1 CDS SAR2169 NC_002952.2 2241054 2242412 R Similar to Escherichia coli UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate --D-alanyl-D- alanyl ligase MurF SW:MURF_ECOLI (P11880) (452 aa) fasta scores: E(): 4.4e-38, 32.23% id in 456 aa, and to Bacillus subtilis UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate --D-alanyl-D- alanyl ligase MurF SW:MURF_BACSU (P96613) (457 aa) fasta scores: E(): 1e-68, 45.51% id in 457 aa; UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-- D-alanyl-D-alanyl ligase complement(2241054..2242412) Staphylococcus aureus subsp. aureus MRSA252 2859089 YP_041532.1 CDS ddl NC_002952.2 2242427 2243497 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(2242427..2243497) Staphylococcus aureus subsp. aureus MRSA252 2859090 YP_041533.1 CDS SAR2171 NC_002952.2 2243815 2245017 D Similar to Escherichia coli rod shape-determining protein RodA SW:RODA_ECOLI (P15035) (370 aa) fasta scores: E(): 4.6e-25, 33.59% id in 387 aa, and to Bacillus subtilis hypothetical protein YwcF SW:YWCF_BACSU (P39604) (393 aa) fasta scores: E(): 9e-46, 37.78% id in 397 aa; hypothetical protein 2243815..2245017 Staphylococcus aureus subsp. aureus MRSA252 2859091 YP_041534.1 CDS SAR2173 NC_002952.2 2246273 2246410 R hypothetical protein complement(2246273..2246410) Staphylococcus aureus subsp. aureus MRSA252 2859093 YP_041535.1 CDS SAR2174 NC_002952.2 2246538 2246747 R Similar to Helicobacter felis divalent cation binding protein CopP SW:COPP_HELFE (O32620) (66 aa) fasta scores: E(): 1, 24.59% id in 61 aa, and to Bacillus halodurans mercuric transporter BH0556 TR:Q9KFC8 (EMBL:AP001508) (67 aa) fasta scores: E(): 0.17, 26.15% id in 65 aa; hypothetical protein complement(2246538..2246747) Staphylococcus aureus subsp. aureus MRSA252 2859094 YP_041536.1 CDS SAR2177 NC_002952.2 2247217 2248701 D Similar to Bacillus firmus cardiolipin synthetase Cls SW:CLS_BACFI (O66043) (503 aa) fasta scores: E(): 3.7e-71, 42.77% id in 498 aa, and to Bacillus subtilis probable cardiolipin synthetase 2 YwnE SW:CLS2_BACSU (P71040) (482 aa) fasta scores: E(): 3.9e-108, 58% id in 481 aa; cardiolipin synthetase 2247217..2248701 Staphylococcus aureus subsp. aureus MRSA252 2859096 YP_041537.1 CDS SAR2178 NC_002952.2 2248729 2249376 D Similar to Bacillus halodurans hypothetical protein BH2835 TR:Q9K916 (EMBL:AP001516) (215 aa) fasta scores: E(): 8.6e-28, 37.5% id in 216 aa, and to Lactococcus lactis hypothetical protein YagB TR:Q9CJD2 (EMBL:AE006245) (216 aa) fasta scores: E(): 5.7e-20, 36.09% id in 205 aa; hypothetical protein 2248729..2249376 Staphylococcus aureus subsp. aureus MRSA252 2859097 YP_041538.1 CDS SAR2179 NC_002952.2 2249989 2250861 R Similar to Bacillus subtilis stage III sporulation protein J precursor SpoIIIJ SW:SP3J_BACSU (Q01625) (261 aa) fasta scores: E(): 3.6e-15, 34.12% id in 252 aa, and to Bacillus halodurans stage III sporulation protein J BH1169 TR:Q9KDP2 (EMBL:AP001511) (280 aa) fasta scores: E(): 1.6e-26, 36.33% id in 289 aa; hypothetical protein complement(2249989..2250861) Staphylococcus aureus subsp. aureus MRSA252 2859098 YP_041539.1 CDS thiE NC_002952.2 2250947 2251588 R Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase complement(2250947..2251588) Staphylococcus aureus subsp. aureus MRSA252 2859526 YP_041540.1 CDS thiM NC_002952.2 2251590 2252381 R catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase complement(2251590..2252381) Staphylococcus aureus subsp. aureus MRSA252 2859528 YP_041541.1 CDS thiD NC_002952.2 2252365 2253195 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(2252365..2253195) Staphylococcus aureus subsp. aureus MRSA252 2859525 YP_041542.1 CDS tenA NC_002952.2 2253188 2253877 R Similar to Bacillus subtilis transcriptional activator of extracellular enzyme genes TenA SW:TENA_BACSU (P25052) (236 aa) fasta scores: E(): 3.9e-07, 23.11% id in 225 aa, and to Staphylococcus carnosus possible transcriptional activator TenA TR:O54496 (EMBL:AF109218) (228 aa) fasta scores: E(): 3.2e-51, 55.75% id in 226 aa; transcriptional activator complement(2253188..2253877) Staphylococcus aureus subsp. aureus MRSA252 2859523 YP_041543.1 CDS SAR2183b NC_002952.2 2254140 2254412 D Doubtful CDS. No database matches; hypothetical protein 2254140..2254412 Staphylococcus aureus subsp. aureus MRSA252 2859099 YP_041544.1 CDS SAR2184 NC_002952.2 2254402 2255097 R Similar to Staphylococcus carnosus hypothetical protein SceD TR:O54493 (EMBL:AF109218) (232 aa) fasta scores: E(): 2.4e-32, 50.82% id in 242 aa, and to Staphylococcus aureus immunodominant antigen A protein IsaA TR:Q9LAB6 (EMBL:AF144681) (233 aa) fasta scores: E(): 7.3e-13, 34.41% id in 247 aa; hypothetical protein complement(2254402..2255097) Staphylococcus aureus subsp. aureus MRSA252 2859100 YP_041545.1 CDS SAR2185 NC_002952.2 2255486 2255881 R Similar to Staphylococcus aureus prophage phiPV83 single strand DNA binding protein TR:Q9MBS1 (EMBL:AB044554) (142 aa) fasta scores: E(): 5.1e-13, 38.73% id in 111 aa, and to Staphylococcus carnosus single-strand binding protein Ssb TR:O54492 (EMBL:AF109218) (145 aa) fasta scores: E(): 1.6e-22, 54.41% id in 136 aa; ssDNA-binding protein complement(2255486..2255881) Staphylococcus aureus subsp. aureus MRSA252 2859101 YP_041546.1 CDS SAR2186 NC_002952.2 2256075 2256515 D Similar to Staphylococcus carnosus hypothetical protein TR:O54491 (EMBL:AF109218) (149 aa) fasta scores: E(): 2.4e-39, 71.81% id in 149 aa, and to Bacillus subtilis hypothetical protein YwpF TR:P94588 (EMBL:Z83337) (136 aa) fasta scores: E(): 8.1e-11, 32.35% id in 136 aa; hypothetical protein 2256075..2256515 Staphylococcus aureus subsp. aureus MRSA252 2859102 YP_041547.1 CDS fabZ NC_002952.2 2256572 2257012 R in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase complement(2256572..2257012) Staphylococcus aureus subsp. aureus MRSA252 2859622 YP_041548.1 CDS murA1 NC_002952.2 2257046 2258311 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(2257046..2258311) Staphylococcus aureus subsp. aureus MRSA252 2861318 YP_041549.1 CDS SAR2189 NC_002952.2 2258422 2258655 R Similar to Bacillus subtilis hypothetical protein YwzB TR:O32278 (EMBL:Z99122) (76 aa) fasta scores: E(): 2.7e-11, 44% id in 75 aa, and to Bacillus halodurans hypothetical protein BH3751 TR:Q9K6H8 (EMBL:AP001519) (77 aa) fasta scores: E(): 2.5e-08, 40% id in 75 aa; hypothetical protein complement(2258422..2258655) Staphylococcus aureus subsp. aureus MRSA252 2861000 YP_041550.1 CDS atpC NC_002952.2 2259534 2259938 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(2259534..2259938) Staphylococcus aureus subsp. aureus MRSA252 2859876 YP_041551.1 CDS atpD NC_002952.2 2259958 2261370 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(2259958..2261370) Staphylococcus aureus subsp. aureus MRSA252 2859877 YP_041552.1 CDS atpG NC_002952.2 2261392 2262258 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(2261392..2262258) Staphylococcus aureus subsp. aureus MRSA252 2859880 YP_041553.1 CDS atpA NC_002952.2 2262289 2263797 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(2262289..2263797) Staphylococcus aureus subsp. aureus MRSA252 2859874 YP_041554.1 CDS atpH NC_002952.2 2263819 2264358 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(2263819..2264358) Staphylococcus aureus subsp. aureus MRSA252 2859881 YP_041555.1 CDS atpF NC_002952.2 2264358 2264879 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel; F0F1 ATP synthase subunit B complement(2264358..2264879) Staphylococcus aureus subsp. aureus MRSA252 2859879 YP_041556.1 CDS atpE NC_002952.2 2265078 2265290 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(2265078..2265290) Staphylococcus aureus subsp. aureus MRSA252 2859878 YP_041557.1 CDS atpB NC_002952.2 2265333 2266061 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(2265333..2266061) Staphylococcus aureus subsp. aureus MRSA252 2859875 YP_041558.1 CDS atpI NC_002952.2 2266082 2266435 R Similar to Bacillus subtilis ATP synthase I AtpI SW:ATPZ_BACSU (P37816) (127 aa) fasta scores: E(): 0.047, 24.34% id in 115 aa, and to Bacillus megaterium ATP synthase I AtpI SW:ATPZ_BACME (P20598) (123 aa) fasta scores: E(): 0.0046, 29.91% id in 117 aa; ATP synthase I complement(2266082..2266435) Staphylococcus aureus subsp. aureus MRSA252 2859882 YP_041559.1 CDS mnaA NC_002952.2 2266598 2267731 R Similar to Staphylococcus aureus UDP-GlcNAc 2-epimerase MnaA TR:Q9REV4 (EMBL:AF209197) (375 aa) fasta scores: E(): 2.9e-135, 96.53% id in 375 aa, and to Bacillus subtilis UDP-N-acetylglucosamine 2-epimerase YvyH SW:YVYH_BACSU (P39131) (380 aa) fasta scores: E(): 2.5e-87, 61.39% id in 373 aa; UDP-GlcNAc 2-epimerase complement(2266598..2267731) Staphylococcus aureus subsp. aureus MRSA252 2861165 YP_041560.1 CDS upp NC_002952.2 2267752 2268381 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(2267752..2268381) Staphylococcus aureus subsp. aureus MRSA252 2860414 YP_041561.1 CDS glyA NC_002952.2 2268409 2269647 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(2268409..2269647) Staphylococcus aureus subsp. aureus MRSA252 2859934 YP_041562.1 CDS SAR2202 NC_002952.2 2269674 2270198 R Similar to Bacillus subtilis hypothetical protein YwlG SW:YWLG_BACSU (P39157) (180 aa) fasta scores: E(): 6.3e-28, 47.61% id in 168 aa, and to Bacillus halodurans hypothetical protein BH3766 TR:Q9K6G3 (EMBL:AP001519) (188 aa) fasta scores: E(): 1.4e-27, 47.39% id in 173 aa; hypothetical protein complement(2269674..2270198) Staphylococcus aureus subsp. aureus MRSA252 2861001 YP_041563.1 CDS SAR2203 NC_002952.2 2270305 2270724 R Similar to Bacillus subtilis low molecular weight protein-tyrosine-phosphatase YwlE SW:YWLE_BACSU (P39155) (150 aa) fasta scores: E(): 2.1e-15, 39.71% id in 141 aa, and to Bacillus halodurans protein-tyrosine-phosphatase BH3769 TR:Q9K6G0 (EMBL:AP001519) (161 aa) fasta scores: E(): 6.2e-09, 34.5% id in 142 aa; low molecular weight protein-tyrosine-phosphatase complement(2270305..2270724) Staphylococcus aureus subsp. aureus MRSA252 2861002 YP_041564.1 CDS SAR2204 NC_002952.2 2270721 2271767 R Similar to Bacillus subtilis hypothetical protein YwlC SW:YWLC_BACSU (P39153) (346 aa) fasta scores: E(): 2.5e-44, 40.22% id in 348 aa, and to Bacillus halodurans hypothetical protein BH3771 TR:Q9K6F8 (EMBL:AP001519) (348 aa) fasta scores: E(): 1.2e-43, 43.93% id in 330 aa; hypothetical protein complement(2270721..2271767) Staphylococcus aureus subsp. aureus MRSA252 2861003 YP_041565.1 CDS SAR2205 NC_002952.2 2271851 2272687 R Similar to Escherichia coli heme biosynthesis protein HemK SW:HEMK_ECOLI (P37186) (277 aa) fasta scores: E(): 3.5e-19, 32.36% id in 275 aa, and to Bacillus subtilis HemK protein homologue SW:HEMK_BACSU (P45873) (288 aa) fasta scores: E(): 1.7e-34, 40.36% id in 275 aa; hypothetical protein complement(2271851..2272687) Staphylococcus aureus subsp. aureus MRSA252 2861004 YP_041566.1 CDS prfA NC_002952.2 2272674 2273750 R recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 complement(2272674..2273750) Staphylococcus aureus subsp. aureus MRSA252 2860148 YP_041567.1 CDS SAR2207 NC_002952.2 2273751 2274350 R catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase complement(2273751..2274350) Staphylococcus aureus subsp. aureus MRSA252 2861005 YP_041568.1 CDS rpmE2 NC_002952.2 2274697 2274951 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(2274697..2274951) Staphylococcus aureus subsp. aureus MRSA252 2860925 YP_041569.1 CDS rho NC_002952.2 2275069 2276385 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(2275069..2276385) Staphylococcus aureus subsp. aureus MRSA252 2859307 YP_041570.1 CDS SAR2210 NC_002952.2 2276632 2278059 R Similar to Bacillus subtilis betaine aldehyde dehydrogenase GbsA SW:DHAB_BACSU (P71016) (490 aa) fasta scores: E(): 1.2e-59, 40.33% id in 476 aa, and to Caulobacter crescentus aldehyde dehydrogenase CC0419 TR:Q9AB15 (EMBL:AE005714) (479 aa) fasta scores: E(): 2.4e-87, 50.94% id in 475 aa; aldehyde dehydrogenase complement(2276632..2278059) Staphylococcus aureus subsp. aureus MRSA252 2861006 YP_041571.1 CDS SAR2211 NC_002952.2 2278297 2278635 R Similar to Bacillus subtilis hypothetical protein YodB SW:YODB_BACSU (O34844) (112 aa) fasta scores: E(): 1.5e-12, 38.46% id in 104 aa, and to Bacillus halodurans hypothetical protein BH3303 TR:Q9RC48 (EMBL:AB024562) (107 aa) fasta scores: E(): 2.2e-08, 36.53% id in 104 aa; hypothetical protein complement(2278297..2278635) Staphylococcus aureus subsp. aureus MRSA252 2860014 YP_041572.1 CDS murA2 NC_002952.2 2278721 2279980 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(2278721..2279980) Staphylococcus aureus subsp. aureus MRSA252 2861319 YP_041573.1 CDS SAR2213 NC_002952.2 2280446 2281306 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; induced by anaerobic conditions in Bacillus subtilis; fructose-bisphosphate aldolase complement(2280446..2281306) Staphylococcus aureus subsp. aureus MRSA252 2860015 YP_041574.1 CDS SAR2214 NC_002952.2 2281524 2282045 D Similar to Bacillus halodurans hypothetical protein BH3788 TR:Q9K6E1 (EMBL:AP001520) (178 aa) fasta scores: E(): 7.4e-06, 25.69% id in 179 aa, and to Bacillus subtilis hypothetical protein YwjG SW:YWJG_BACSU (P06629) (173 aa) fasta scores: E(): 5e-05, 29.54% id in 176 aa; hypothetical protein 2281524..2282045 Staphylococcus aureus subsp. aureus MRSA252 2860016 YP_041575.1 CDS pyrG NC_002952.2 2282154 2283764 R CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(2282154..2283764) Staphylococcus aureus subsp. aureus MRSA252 2859288 YP_041576.1 CDS rpoE NC_002952.2 2284100 2284630 R participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta complement(2284100..2284630) Staphylococcus aureus subsp. aureus MRSA252 2860172 YP_041577.1 CDS SAR2217 NC_002952.2 2284742 2285602 R Similar to Bacillus subtilis spermine/spermidine acetyltransferase BltD SW:BLTD_BACSU (P39909) (152 aa) fasta scores: E(): 0.0005, 27.4% id in 135 aa, and to Bacillus halodurans hypothetical protein BH3804 TR:Q9K6C5 (EMBL:AP001520) (167 aa) fasta scores: E(): 1.4e-15, 39.1% id in 156 aa; acetyltransferase complement(2284742..2285602) Staphylococcus aureus subsp. aureus MRSA252 2860017 YP_041578.1 CDS SAR2218 NC_002952.2 2286026 2286829 D catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type II pantothenate kinases are not regulated by feedback inhibition by coenzyme A; pantothenate kinase 2286026..2286829 Staphylococcus aureus subsp. aureus MRSA252 2860018 YP_041579.1 CDS SAR2219 NC_002952.2 2286955 2287626 R No significant database matches to the full length CDS. N-terminus is weakly similar to N-terminal region of Caenorhabditis elegans hypothetical protein Y71F9AL.1 TR:Q9N4H1 (EMBL:AC024200) (323 aa) fasta scores: E(): 9, 24.82% id in 141 aa; hypothetical protein complement(2286955..2287626) Staphylococcus aureus subsp. aureus MRSA252 2860127 YP_041580.1 CDS SAR2220 NC_002952.2 2288025 2289218 R No significant database matches to the full length CDS. N-terminus is weakly similar to N-terminal region of Pasteurella haemolytica probable phosphoribosylglycinamide formyltransferase 2 PurT SW:PURT_PASHA (P46927) (392 aa) fasta scores: E(): 4.2, 22.83% id in 289 aa; hypothetical protein complement(2288025..2289218) Staphylococcus aureus subsp. aureus MRSA252 2860050 YP_041581.1 CDS SAR2221 NC_002952.2 2289218 2290402 R N-terminus is similar to N-terminal region of Escherichia coli aminobenzoyl-glutamate utilization protein B AbgB SW:ABGB_ECOLI (P76052) (481 aa) fasta scores: E(): 2.9e-14, 32.98% id in 285 aa. Similar to full length Mycobacterium tuberculosis aminohydrolase RV3306c TR:O53358 (EMBL:AL021841) (394 aa) fasta scores: E(): 1.4e-36, 33.59% id in 381 aa; peptidase complement(2289218..2290402) Staphylococcus aureus subsp. aureus MRSA252 2860051 YP_041582.1 CDS luxS NC_002952.2 2290712 2291182 D catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2290712..2291182 Staphylococcus aureus subsp. aureus MRSA252 2859811 YP_041583.1 CDS SAR2223 NC_002952.2 2291334 2291684 R Similar to Deinococcus radiodurans hypothetical protein DR2024 TR:Q9RSU8 (EMBL:AE002039) (120 aa) fasta scores: E(): 2e-10, 41.74% id in 103 aa, and to Pseudomonas aeruginosa hypothetical protein PA0806 TR:Q9I5D2 (EMBL:AE004515) (131 aa) fasta scores: E(): 0.00064, 34.25% id in 108 aa; hypothetical protein complement(2291334..2291684) Staphylococcus aureus subsp. aureus MRSA252 2860052 YP_041584.1 CDS pyn NC_002952.2 2291698 2292999 R Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase complement(2291698..2292999) Staphylococcus aureus subsp. aureus MRSA252 2859281 YP_041585.1 CDS deoC2 NC_002952.2 2293279 2293941 R catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase complement(2293279..2293941) Staphylococcus aureus subsp. aureus MRSA252 2859588 YP_041586.1 CDS deoD NC_002952.2 2294256 2294966 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 2294256..2294966 Staphylococcus aureus subsp. aureus MRSA252 2859590 YP_041587.1 CDS SAR2227 NC_002952.2 2295087 2295530 R Similar to Listeria innocua non-heme iron-containing ferritin SW:FRI_LISIN (P80725) (156 aa) fasta scores: E(): 9.5e-21, 43.83% id in 146 aa, and to Bacillus subtilis general stress protein 20U SW:G20U_BACSU (P80879) (144 aa) fasta scores: E(): 1.2e-28, 52.11% id in 142 aa; non-heme iron-containing ferritin complement(2295087..2295530) Staphylococcus aureus subsp. aureus MRSA252 2860053 YP_041588.1 CDS SAR2228 NC_002952.2 2295730 2296143 R Similar to Bacillus halodurans hypothetical protein BH0852 TR:Q9KEK0 (EMBL:AP001510) (134 aa) fasta scores: E(): 1.3e-08, 31.57% id in 133 aa, and to Bacillus subtilis hypothetical protein YuxK SW:YUXK_BACSU (P40761) (137 aa) fasta scores: E(): 5.3e-06, 30.23% id in 129 aa; hypothetical protein complement(2295730..2296143) Staphylococcus aureus subsp. aureus MRSA252 2860054 YP_041589.1 CDS SAR2229 NC_002952.2 2296592 2297965 R hypothetical protein complement(2296592..2297965) Staphylococcus aureus subsp. aureus MRSA252 2860055 YP_041590.1 CDS SAR2230 NC_002952.2 2298638 2298868 R Doubtful CDS. No significant database matches; hypothetical protein complement(2298638..2298868) Staphylococcus aureus subsp. aureus MRSA252 2860056 YP_041591.1 CDS SAR2231 NC_002952.2 2298899 2299837 R Similar to Streptococcus mutans mannose-6-phosphate isomerase Pmi SW:MANA_STRMU (Q59935) (316 aa) fasta scores: E(): 3e-56, 46.62% id in 311 aa, and to Bacillus halodurans mannnose-6 phosphate isomerase BH3916 TR:Q9Z9T1 (EMBL:AB011838) (315 aa) fasta scores: E(): 3.7e-57, 43.59% id in 312 aa; mannose-6-phosphate isomerase complement(2298899..2299837) Staphylococcus aureus subsp. aureus MRSA252 2860057 YP_041592.1 CDS SAR2232 NC_002952.2 2300273 2300938 R Similar to Bacillus subtilis hypothetical protein YhfK TR:O07609 (EMBL:Y14083) (214 aa) fasta scores: E(): 2.6e-23, 41.81% id in 220 aa, and to Bacillus halodurans hypothetical protein BH1520 TR:Q9KCP9 (EMBL:AP001512) (213 aa) fasta scores: E(): 3.9e-21, 36.81% id in 220 aa; hypothetical protein complement(2300273..2300938) Staphylococcus aureus subsp. aureus MRSA252 2860058 YP_041593.1 CDS czrA NC_002952.2 2301090 2301410 D Previously sequenced as Staphylococcus aureus zinc and cobalt transport repressor protein CzrA TR:O85142 (EMBL:AF044951) (106 aa) fasta scores: E(): 4e-38, 100% id in 106 aa. Similar to Bacillus subtilis hypothetical protein YozA TR:O31844 (EMBL:Z99114) (107 aa) fasta scores: E(): 2e-13, 49% id in 100 aa; zinc and cobalt transport repressor protein 2301090..2301410 Staphylococcus aureus subsp. aureus MRSA252 2859259 YP_041594.1 CDS czrB NC_002952.2 2301412 2302392 D Previously sequenced as Staphylococcus aureus zinc resistance protein CzrB TR:Q9ZNF5 (EMBL:AB016431) (325 aa) fasta scores: E(): 3.2e-116, 98.46% id in 326 aa. Similar to Bacillus subtilis cation transport protein YrdO TR:O07084 (EMBL:U93876) (311 aa) fasta scores: E(): 4.1e-62, 56.95% id in 309 aa; zinc resistance protein 2301412..2302392 Staphylococcus aureus subsp. aureus MRSA252 2859260 YP_041595.1 CDS SAR2235 NC_002952.2 2302658 2303749 D No significant database matches. Previously sequenced as Staphylococcus aureus lytic regulatory protein TR:Q9ZB00 (EMBL:U67965) (370 aa) fasta scores: E(): 4.1e-113, 97.5% id in 360 aa; hypothetical protein 2302658..2303749 Staphylococcus aureus subsp. aureus MRSA252 2860059 YP_041597.1 CDS SAR2239 NC_002952.2 2307489 2307581 D Doubtful CDS. No database matches; hypothetical protein 2307489..2307581 Staphylococcus aureus subsp. aureus MRSA252 2860063 YP_041598.1 CDS SAR2240 NC_002952.2 2307711 2308568 R Similar to Bacillus halodurans hypothetical protein BH1746 TR:Q9KC28 (EMBL:AP001513) (282 aa) fasta scores: E(): 8.6e-14, 28.47% id in 288 aa, and to Bacillus subtilis hypothetical protein YwpJ TR:P94592 (EMBL:Z83337) (285 aa) fasta scores: E(): 6.1e-13, 24.74% id in 291 aa; haloacid dehalogenase-like hydrolase complement(2307711..2308568) Staphylococcus aureus subsp. aureus MRSA252 2860064 YP_041599.1 CDS SAR2241 NC_002952.2 2308636 2309418 R Similar to Thermoactinomyces vulgaris ATP-binding protein-homologue Orf-4 TR:Q9AJF6 (EMBL:AB047926) (266 aa) fasta scores: E(): 5.8e-34, 47.12% id in 261 aa, and to the C-terminal region Escherichia coli molybdenum transport ATP-binding protein ModF SW:MODF_ECOLI (P31060) (490 aa) fasta scores: E(): 1.3e-17, 35.71% id in 224 aa; ABC transporter ATP-binding protein complement(2308636..2309418) Staphylococcus aureus subsp. aureus MRSA252 2860065 YP_041600.1 CDS glmS NC_002952.2 2309650 2311455 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(2309650..2311455) Staphylococcus aureus subsp. aureus MRSA252 2859920 YP_041601.1 CDS SAR2243 NC_002952.2 2311923 2312120 D Poor database matches. Doubtful CDS; hypothetical protein 2311923..2312120 Staphylococcus aureus subsp. aureus MRSA252 2860066 YP_041602.1 CDS mtlA NC_002952.2 2312136 2313674 D Similar to Staphylococcus carnosus PTS system, mannitol-specific IIBC component MtlA SW:PTMB_STACA (P28008) (518 aa) fasta scores: E(): 2.5e-163, 84.01% id in 513 aa, and to Bacillus halodurans PTS system, mannitol-specific IIBC component BH3854 SW:PTMB_BACHD (Q9K678) (468 aa) fasta scores: E(): 1.1e-80, 55.35% id in 495 aa; PTS system mannitol-specific transporter subunit IIBC 2312136..2313674 Staphylococcus aureus subsp. aureus MRSA252 2861315 YP_041603.1 CDS SAR2245 NC_002952.2 2313709 2315841 D Similar to Bacillus subtilis cel operon transcriptional regulator (antiterminator) CelR SW:CELR_BACSU (P46321) (641 aa) fasta scores: E(): 4.9e-13, 24.24% id in 532 aa, and to Bacillus subtilis probable LysR family transcriptional regulator YdaA TR:P96574 (EMBL:AB001488) (694 aa) fasta scores: E(): 7e-50, 29.89% id in 726 aa; transcriptional antiterminator 2313709..2315841 Staphylococcus aureus subsp. aureus MRSA252 2860067 YP_041604.1 CDS mtlF NC_002952.2 2315853 2316287 D Previously sequenced as Staphylococcus aureus PTS system, mannitol-specific IIA component MtlF SW:PTMA_STAAU (P17875) (143 aa) fasta scores: E(): 5.1e-49, 99.3% id in 143 aa. Similar to Staphylococcus carnosus PTS system, mannitol-specific IIA component MtlF SW:PTMA_STACA (P17876) (143 aa) fasta scores: E(): 4.7e-39, 81.69% id in 142 aa; PTS system mannitol-specific transporter subunit IIA 2315853..2316287 Staphylococcus aureus subsp. aureus MRSA252 2861317 YP_041605.1 CDS mtlD NC_002952.2 2316287 2317393 D Similar to Streptococcus mutans mannitol-1-phosphate 5-dehydrogenase MtlD SW:MTLD_STRMU (Q02418) (382 aa) fasta scores: E(): 8.5e-30, 41.68% id in 379 aa. Previously sequenced as Staphylococcus aureus mannitol-1-phosphate 5-dehydrogenase TR:Q9RL68 (EMBL:Y09927) (368 aa) fasta scores: E(): 2.6e-131, 98.09% id in 368 aa; mannitol-1-phosphate 5-dehydrogenase 2316287..2317393 Staphylococcus aureus subsp. aureus MRSA252 2861316 YP_041606.1 CDS SAR2251 NC_002952.2 2325364 2327010 R Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 7e-199, 99.453% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 3e-99, 52.115% id in 520 aa; transposase complement(2325364..2327010) Staphylococcus aureus subsp. aureus MRSA252 2860068 YP_041607.1 CDS glmM NC_002952.2 2327307 2328662 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(2327307..2328662) Staphylococcus aureus subsp. aureus MRSA252 2860069 YP_041608.1 CDS SAR2253 NC_002952.2 2328689 2329621 R Similar to Streptococcus pyogenes hypothetical protein SPY1037 TR:Q99ZW9 (EMBL:AE006548) (318 aa) fasta scores: E(): 6.5e-10, 24.83% id in 310 aa, and to the N-terminal region of Bacillus subtilis hypothetical protein YbbR TR:O34659 (EMBL:Z99104) (483 aa) fasta scores: E(): 2.2e-20, 28.25% id in 315 aa; hypothetical protein complement(2328689..2329621) Staphylococcus aureus subsp. aureus MRSA252 2860070 YP_041609.1 CDS SAR2254 NC_002952.2 2329623 2330432 R Similar to Bacillus subtilis hypothetical protein YbbQ TR:Q45589 (EMBL:Z99104) (273 aa) fasta scores: E(): 2.5e-52, 56.42% id in 257 aa, and to Bacillus halodurans hypothetical protein BH0265 TR:Q9KG48 (EMBL:AP001507) (274 aa) fasta scores: E(): 3.6e-48, 56.22% id in 249 aa; hypothetical protein complement(2329623..2330432) Staphylococcus aureus subsp. aureus MRSA252 2860071 YP_041610.1 CDS rocF NC_002952.2 2330622 2331530 R Similar to Bacillus caldovelox arginase RocF SW:ARGI_BACCD (P53608) (299 aa) fasta scores: E(): 3.1e-57, 53% id in 300 aa, and to Bacillus subtilis arginase RocF SW:ARGI_BACSU (P39138) (296 aa) fasta scores: E(): 4e-55, 51.66% id in 300 aa; arginase complement(2330622..2331530) Staphylococcus aureus subsp. aureus MRSA252 2860896 YP_041611.1 CDS SAR2256 NC_002952.2 2337747 2338811 R Similar to Bacillus subtilis Mrp protein homologue YbaL SW:MRP_BACSU (P50863) (352 aa) fasta scores: E(): 1.9e-84, 63.53% id in 351 aa, and to Bacillus halodurans ATP-binding Mrp protein BH0240 TR:Q9KG72 (EMBL:AP001507) (350 aa) fasta scores: E(): 7.9e-76, 60.84% id in 355 aa; hypothetical protein complement(2337747..2338811) Staphylococcus aureus subsp. aureus MRSA252 2860072 YP_041612.1 CDS SAR2259 NC_002952.2 2340591 2341058 R Poor database matches. Similar to Borrelia burgdorferi conserved hypothetical integral membrane protein BB0717 TR:O51659 (EMBL:AE001171) (160 aa) fasta scores: E(): 0.24, 30.08% id in 123 aa; hypothetical protein complement(2340591..2341058) Staphylococcus aureus subsp. aureus MRSA252 2860074 YP_041613.1 CDS SAR2260 NC_002952.2 2341186 2342529 R Similar to Vibrio cholerae multidrug transporter VC1597 TR:Q9KRN9 (EMBL:AE004237) (477 aa) fasta scores: E(): 2.2e-29, 28.81% id in 413 aa, and to Deinococcus radiodurans multidrug-efflux transporter DR1327 TR:Q9RUQ5 (EMBL:AE001979) (477 aa) fasta scores: E(): 1.4e-27, 26.83% id in 436 aa; transport protein complement(2341186..2342529) Staphylococcus aureus subsp. aureus MRSA252 2860075 YP_041614.1 CDS SAR2261 NC_002952.2 2342707 2343390 R Similar to Bacillus cereus hemolysin III SW:HLY3_BACCE (P54176) (219 aa) fasta scores: E(): 2.5e-20, 34.8% id in 204 aa, and to Streptococcus pyogenes hemolysin III SPY1159 TR:Q99ZM9 (EMBL:AE006557) (216 aa) fasta scores: E(): 1e-42, 55.14% id in 214 aa; hypothetical protein complement(2342707..2343390) Staphylococcus aureus subsp. aureus MRSA252 2860076 YP_041615.1 CDS SAR2262 NC_002952.2 2343409 2344596 R Similar to Saccharomyces cerevisiae UDP-N-acetylglucosamine pyrophosphorylase UAP1 SW:UAP1_YEAST (P43123) (477 aa) fasta scores: E(): 3.5e-28, 33.41% id in 407 aa, and to Chlamydia trachomatis AgX-1 homolog-UDP-glucose pyrophosphorylase CT715 TR:O84720 (EMBL:AE001342) (455 aa) fasta scores: E(): 2.6e-26, 30.92% id in 401 aa; UTP--glucose-1-phosphate uridylyltransferase complement(2343409..2344596) Staphylococcus aureus subsp. aureus MRSA252 2860077 YP_041616.1 CDS SAR2263 NC_002952.2 2344640 2345155 R Similar to Bacillus subtilis hypothetical protein YvsG SW:YVSG_BACSU (O32205) (160 aa) fasta scores: E(): 7.1e-18, 37.97% id in 158 aa, and to Bacillus halodurans hypothetical protein BH2138 TR:Q9KAZ8 (EMBL:AP001514) (159 aa) fasta scores: E(): 1e-14, 34.61% id in 156 aa; hypothetical protein complement(2344640..2345155) Staphylococcus aureus subsp. aureus MRSA252 2860078 YP_041617.1 CDS SAR2264 NC_002952.2 2345332 2345592 D Similar to Bacillus subtilis hypothetical protein YnzG TR:O31800 (EMBL:Z99113) (83 aa) fasta scores: E(): 7.9e-05, 29.76% id in 84 aa, and to Bacillus halodurans hypothetical protein BH3607 TR:Q9K6W7 (EMBL:AP001519) (83 aa) fasta scores: E(): 0.049, 34.21% id in 76 aa; hypothetical protein 2345332..2345592 Staphylococcus aureus subsp. aureus MRSA252 2860079 YP_041618.1 CDS SAR2265 NC_002952.2 2345724 2347094 R Similar to Bacillus halodurans hypothetical protein BH3947 TR:Q9K5Y8 (EMBL:AP001520) (460 aa) fasta scores: E(): 3.2e-76, 47.31% id in 465 aa, and to Vibrio cholerae hypothetical protein VCA0076 TR:Q9KN89 (EMBL:AE004350) (458 aa) fasta scores: E(): 1.3e-73, 46.48% id in 441 aa; hypothetical protein complement(2345724..2347094) Staphylococcus aureus subsp. aureus MRSA252 2860080 YP_041619.1 CDS SAR2266 NC_002952.2 2347330 2348298 R Similar to Escherichia coli citrate-dependent iron transport protein FecD SW:FECD_ECOLI (P15029) (318 aa) fasta scores: E(): 1.1e-38, 39.8% id in 314 aa, and to Bacillus subtilis hypothetical protein YfmE TR:O34832 (EMBL:Z99108) (333 aa) fasta scores: E(): 8.6e-50, 46.3% id in 311 aa; FecCD transport family protein complement(2347330..2348298) Staphylococcus aureus subsp. aureus MRSA252 2860081 YP_041620.1 CDS SAR2267 NC_002952.2 2348295 2349326 R Similar to Bacillus subtilis ferrichrome ABC transporter permease FhuB SW:FHUB_BACSU (P49936) (384 aa) fasta scores: E(): 2.7e-39, 37.03% id in 324 aa, and to Bacillus subtilis hypothetical protein YfmD TR:O34933 (EMBL:Z99108) (333 aa) fasta scores: E(): 3.2e-54, 46.97% id in 330 aa; FecCD transport family protein complement(2348295..2349326) Staphylococcus aureus subsp. aureus MRSA252 2860082 YP_041621.1 CDS SAR2268 NC_002952.2 2349338 2350321 R Similar to Escherichia coli iron citrate-dependent iron transport, periplasmic protein FecB SW:FECB_ECOLI (P15028) (300 aa) fasta scores: E(): 2.9e-20, 37.23% id in 282 aa, and to Bacillus subtilis hypothetical protein YhfQ TR:O07616 (EMBL:Y14084) (348 aa) fasta scores: E(): 2e-32, 38.6% id in 316 aa; transport system binding lipoprotein complement(2349338..2350321) Staphylococcus aureus subsp. aureus MRSA252 2860083 YP_041622.1 CDS SAR2269 NC_002952.2 2350714 2351784 R Similar to Thermotoga maritima hypothetical protein TM1597 TR:Q9X1T3 (EMBL:AE001804) (354 aa) fasta scores: E(): 2.3e-17, 28.32% id in 346 aa. N-terminus is weakly similar to the N-terminal region of Staphylococcus aureus alanine racemase Alr SW:ALR_STAAU (Q9ZAH5) (382 aa) fasta scores: E(): 0.018, 22.65% id in 256 aa; hypothetical protein complement(2350714..2351784) Staphylococcus aureus subsp. aureus MRSA252 2860084 YP_041623.1 CDS SAR2270 NC_002952.2 2351791 2353548 R Similar to Rhizobium sp hypothetical protein Y4xN SW:Y4XN_RHISN (P55706) (628 aa) fasta scores: E(): 4.9e-10, 22.36% id in 617 aa, and to Escherichia coli aerobactin siderophore biosynthesis protein IucA SW:IUCA_ECOLI (Q47316) (575 aa) fasta scores: E(): 2.1e-05, 21.64% id in 596 aa; hypothetical protein complement(2351791..2353548) Staphylococcus aureus subsp. aureus MRSA252 2860085 YP_041624.1 CDS SAR2271 NC_002952.2 2353535 2354728 R Similar to Zymomonas mobilis transporter DitE TR:Q9XBR9 (EMBL:AF157493) (431 aa) fasta scores: E(): 5.6e-22, 26.3% id in 403 aa, and to Mycobacterium smegmatis hypothetical membrane protein TR:Q50396 (EMBL:U46844) (412 aa) fasta scores: E(): 1.2e-17, 24.73% id in 376 aa; hypothetical protein complement(2353535..2354728) Staphylococcus aureus subsp. aureus MRSA252 2860086 YP_041625.1 CDS SAR2272 NC_002952.2 2354830 2356806 D Internal region of the CDS is similar to the internal regions of Escherichia coli aerobactin siderophore biosynthesis protein IucC SW:IUCC_ECOLI (Q47318) (580 aa) fasta scores: E(): 2e-07, 22.91% id in 384 aa, and Rhizobium sp hypothetical protein Y4xN SW:Y4XN_RHISN (P55706) (628 aa) fasta scores: E(): 3.2e-10, 24.02% id in 412 aa; hypothetical protein 2354830..2356806 Staphylococcus aureus subsp. aureus MRSA252 2860087 YP_041626.1 CDS asp23 NC_002952.2 2356967 2357476 R Previously sequenced as Staphylococcus aureus alkaline shock protein 23 Asp23 TR:Q53485 (EMBL:S76213) (169 aa) fasta scores: E(): 6.8e-55, 100% id in 169 aa. Similar to Lactococcus lactis hypothetical protein YmgG TR:Q9CG71 (EMBL:AE006356) (183 aa) fasta scores: E(): 1.3e-13, 40.94% id in 127 aa; alkaline shock protein 23 complement(2356967..2357476) Staphylococcus aureus subsp. aureus MRSA252 2859871 YP_041627.1 CDS SAR2274 NC_002952.2 2357539 2357778 R Similar to Streptococcus pyogenes hypothetical protein SPY1263 TR:Q99ZE4 (EMBL:AE006565) (62 aa) fasta scores: E(): 0.012, 36.06% id in 61 aa, and to Lactococcus lactis hypothetical protein YmgH TR:Q9CG70 (EMBL:AE006356) (62 aa) fasta scores: E(): 0.041, 34.42% id in 61 aa; hypothetical protein complement(2357539..2357778) Staphylococcus aureus subsp. aureus MRSA252 2860088 YP_041628.1 CDS SAR2275 NC_002952.2 2357791 2358327 R Poor database matches. Similar to Lactococcus lactis unknown protein YtgA TR:Q9CEF1 (EMBL:AE006418) (186 aa) fasta scores: E(): 0.053, 24.13% id in 174 aa; hypothetical protein complement(2357791..2358327) Staphylococcus aureus subsp. aureus MRSA252 2860089 YP_041629.1 CDS opuD2 NC_002952.2 2358502 2360064 R Similar to Bacillus subtilis glycine betaine transporter OpuD SW:OPUD_BACSU (P54417) (512 aa) fasta scores: E(): 5.6e-102, 53.15% id in 508 aa, and to Listeria monocytogenes glycine betaine transporter BetL TR:Q9X4A5 (EMBL:AF102174) (507 aa) fasta scores: E(): 3.7e-99, 52.43% id in 492 aa; glycine betaine transporter 2 complement(2358502..2360064) Staphylococcus aureus subsp. aureus MRSA252 2861470 YP_041630.1 CDS SAR2277 NC_002952.2 2360372 2361379 R Similar to Bacillus halodurans alginate lyase BH0738 TR:Q9KEW1 (EMBL:AP001509) (339 aa) fasta scores: E(): 5.7e-47, 43.75% id in 336 aa, and to Lactococcus lactis quinone oxidoreductase Qor TR:Q9CHL2 (EMBL:AE006305) (328 aa) fasta scores: E(): 3e-40, 40.47% id in 336 aa; zinc-binding dehydrogenase complement(2360372..2361379) Staphylococcus aureus subsp. aureus MRSA252 2860090 YP_041631.1 CDS SAR2278 NC_002952.2 2361614 2362618 R Similar to Bacillus subtilis hypothetical protein YfmJ TR:O34812 (EMBL:Z99108) (339 aa) fasta scores: E(): 5.4e-62, 52.55% id in 333 aa, and to Escherichia coli NADP-dependent oxidoreductase YncB SW:YNCB_ECOLI (P76113) (353 aa) fasta scores: E(): 2.6e-52, 45.85% id in 338 aa; zinc-binding dehydrogenase complement(2361614..2362618) Staphylococcus aureus subsp. aureus MRSA252 2860091 YP_041632.1 CDS SAR2279 NC_002952.2 2362898 2363767 R C-terminus region is similar to the C-terminal regions of Lactococcus lactis hypothetical protein YriC TR:Q9CEV4 (EMBL:AE006403) (282 aa) fasta scores: E(): 4.4e-09, 24% id in 250 aa, and Lactococcus lactis hypothetical protein TR:Q9ZB16 (EMBL:U60828) (307 aa) fasta scores: E(): 7.2e-08, 22.98% id in 248 aa; hypothetical protein complement(2362898..2363767) Staphylococcus aureus subsp. aureus MRSA252 2861024 YP_041633.1 CDS lacG NC_002952.2 2364033 2365445 R catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase complement(2364033..2365445) Staphylococcus aureus subsp. aureus MRSA252 2859693 YP_041634.1 CDS lacE NC_002952.2 2365463 2367175 R Previously sequenced as Staphylococcus aureus PTS system, lactose-specific IIBC component LacE SW:PTLB_STAAU (P11162) (572 aa) fasta scores: E(): 1.3e-216, 99.82% id in 570 aa. Similar to Streptococcus mutans PTS system, lactose-specific IIBC component LacE SW:PTLB_STRMU (P50976) (568 aa) fasta scores: E(): 1.1e-168, 76.27% id in 569 aa; PTS system lactose-specific transporter subunit IIBC complement(2365463..2367175) Staphylococcus aureus subsp. aureus MRSA252 2859691 YP_041635.1 CDS lacF NC_002952.2 2367181 2367492 R Previously sequenced as Staphylococcus aureus PTS system, lactose-specific IIA component LacF SW:PTLA_STAAU (P02909) (103 aa) fasta scores: E(): 8.2e-39, 100% id in 103 aa. Similar to Streptococcus pyogenes pts system, lactose-specific component iia lacf or spy1918 TR:Q99Y16 (EMBL:AE006616) (105 aa) fasta scores: E(): 6e-30, 76.69% id in 103 aa; PTS system lactose-specific transporter subunit IIA complement(2367181..2367492) Staphylococcus aureus subsp. aureus MRSA252 2859692 YP_041636.1 CDS lacD NC_002952.2 2367514 2368494 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(2367514..2368494) Staphylococcus aureus subsp. aureus MRSA252 2859690 YP_041637.1 CDS lacC NC_002952.2 2368498 2369430 R catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase complement(2368498..2369430) Staphylococcus aureus subsp. aureus MRSA252 2859689 YP_041638.1 CDS lacB NC_002952.2 2369443 2369958 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(2369443..2369958) Staphylococcus aureus subsp. aureus MRSA252 2859688 YP_041639.1 CDS lacA NC_002952.2 2369974 2370402 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA complement(2369974..2370402) Staphylococcus aureus subsp. aureus MRSA252 2859687 YP_041640.1 CDS lacR NC_002952.2 2370769 2371524 R Previously sequenced as Staphylococcus aureus lactose phosphotransferase system repressor LacR SW:LACR_STAAU (P16644) (251 aa) fasta scores: E(): 4.7e-93, 99.2% id in 251 aa. Similar to Streptococcus mutans lactose phosphotransferase system repressor LacR SW:LACR_STRMU (P26422) (251 aa) fasta scores: E(): 4.2e-62, 62.94% id in 251 aa; lactose phosphotransferase system repressor complement(2370769..2371524) Staphylococcus aureus subsp. aureus MRSA252 2859694 YP_041641.1 CDS SAR2288 NC_002952.2 2371775 2372506 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 2371775..2372506 Staphylococcus aureus subsp. aureus MRSA252 2861025 YP_041642.1 CDS SAR2289 NC_002952.2 2372764 2373372 R Poor database matches. Similar to Bacillus subtilis hypothetical protein YnaE TR:P94483 (EMBL:U66480) (213 aa) fasta scores: E(): 3.2e-08, 26.13% id in 199 aa; hypothetical protein complement(2372764..2373372) Staphylococcus aureus subsp. aureus MRSA252 2861026 YP_041643.1 CDS SAR2289a NC_002952.2 2373634 2373759 R Doubtful CDS. No database matches; hypothetical protein complement(2373634..2373759) Staphylococcus aureus subsp. aureus MRSA252 2861027 YP_041644.1 CDS SAR2290 NC_002952.2 2373980 2374828 R Similar to Thermotoga maritima aldo/keto reductase oxidoreductase TM1009 TR:Q9X0A2 (EMBL:AE001762) (286 aa) fasta scores: E(): 3.6e-55, 53.95% id in 278 aa, and to Lactococcus lactis oxidoreductase YddB TR:Q9CIM3 (EMBL:AE006270) (272 aa) fasta scores: E(): 6.2e-40, 46.15% id in 273 aa; aldo/keto reductase complement(2373980..2374828) Staphylococcus aureus subsp. aureus MRSA252 2861028 YP_041645.1 CDS SAR2291 NC_002952.2 2374898 2375314 R Similar to Escherichia coli zinc (II) responsive transcriptional activator ZntR SW:ZNTR_ECOLI (P36676) (141 aa) fasta scores: E(): 0.00023, 27.77% id in 108 aa, and to Bacillus subtilis mercuric resistance operon regulatory protein YraB TR:O06008 (EMBL:X92868) (140 aa) fasta scores: E(): 3.7e-10, 36.56% id in 134 aa. Contains coiled-coiled domain, residues 88 to 105; MerR family transcriptional regulator complement(2374898..2375314) Staphylococcus aureus subsp. aureus MRSA252 2861029 YP_041646.1 CDS hysA2 NC_002952.2 2375721 2378147 D Similar to Staphylococcus aureus hyaluronate lyase precursor HysA SW:HYSA_STAAU (Q59801) (807 aa) fasta scores: E(): 0, 87.5% id in 808 aa, and to Streptococcus pneumoniae hyaluronate lyase precursor SP0314 SW:HYSA_STRPN (Q54873) (949 aa) fasta scores: E(): 5.3e-78, 36.75% id in 770 aa. Similar to SAR1892, 74.969% identity (75.716% ungapped) in 811 aa overlap; hyaluronate lyase precursor 2 2375721..2378147 Staphylococcus aureus subsp. aureus MRSA252 2859654 YP_041647.1 CDS SAR2293 NC_002952.2 2378207 2379061 R Poor database matches. C-terminus is similar to the C-terminal region of Borrelia burgdorferi conserved hypothetical protein BB0761 TR:O51702 (EMBL:AE001176) (295 aa) fasta scores: E(): 4.6e-06, 24.46% id in 233 aa; M23/M37 familypeptidase complement(2378207..2379061) Staphylococcus aureus subsp. aureus MRSA252 2861030 YP_041648.1 CDS SAR2294 NC_002952.2 2379272 2380087 R Similar to Bacillus subtilis hypothetical protein YhjK TR:O07565 (EMBL:Y14081) (286 aa) fasta scores: E(): 3.7e-25, 30.03% id in 263 aa, and to Pasteurella multocida hypothetical protein PM1047 pm1047 TR:Q9CM01 (EMBL:AE006146) (276 aa) fasta scores: E(): 1.3e-15, 26.56% id in 256 aa; hypothetical protein complement(2379272..2380087) Staphylococcus aureus subsp. aureus MRSA252 2861031 YP_041649.1 CDS SAR2295 NC_002952.2 2380382 2380807 D Poor database matches. Similar to the N-terminal region of Staphylococcus aureus cell surface protein Map-W precursor protein TR:Q9S2Z4 (EMBL:AJ245439) (687 aa) fasta scores: E(): 9.1e-06, 34.02% id in 144 aa. Possible gene remnant; hypothetical protein 2380382..2380807 Staphylococcus aureus subsp. aureus MRSA252 2861032 YP_041650.1 CDS SAR2296 NC_002952.2 2381198 2381902 R Similar to Bacillus subtilis alpha-acetolactate decarboxylase AlsD SW:ALDC_BACSU (Q04777) (255 aa) fasta scores: E(): 4.1e-25, 34.33% id in 233 aa, and to Enterobacter aerogenes alpha-acetolactate decarboxylase BudA SW:ALDC_ENTAE (P05361) (260 aa) fasta scores: E(): 5.5e-22, 33.33% id in 234 aa. Similar to SAR2679, 74.359% identity (74.359% ungapped) in 234 aa overlap; hypothetical protein complement(2381198..2381902) Staphylococcus aureus subsp. aureus MRSA252 2861033 YP_041651.1 CDS SAR2297 NC_002952.2 2381939 2383603 R catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; acetolactate synthase complement(2381939..2383603) Staphylococcus aureus subsp. aureus MRSA252 2861034 YP_041652.1 CDS SAR2297a NC_002952.2 2383883 2383999 D Doubtful CDS; hypothetical protein 2383883..2383999 Staphylococcus aureus subsp. aureus MRSA252 2861035 YP_041653.1 CDS SAR2297b NC_002952.2 2384073 2384255 R Doubtful CDS; hypothetical protein complement(2384073..2384255) Staphylococcus aureus subsp. aureus MRSA252 2861036 YP_041654.1 CDS SAR2299 NC_002952.2 2385333 2386784 R Similar to Campylobacter jejuni hypothetical protein CJ1552c TR:Q9PMB7 (EMBL:AL139079) (488 aa) fasta scores: E(): 0.00033, 21.5% id in 479 aa, and to Pyrococcus abyssi hypothetical protein PAB1002 TR:Q9UYK0 (EMBL:AJ248287) (428 aa) fasta scores: E(): 0.015, 25.05% id in 467 aa; hypothetical protein complement(2385333..2386784) Staphylococcus aureus subsp. aureus MRSA252 2861038 YP_041655.1 CDS rpsI NC_002952.2 2387118 2387510 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(2387118..2387510) Staphylococcus aureus subsp. aureus MRSA252 2860180 YP_041656.1 CDS rplM NC_002952.2 2387530 2387967 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(2387530..2387967) Staphylococcus aureus subsp. aureus MRSA252 2860908 YP_041657.1 CDS truA NC_002952.2 2388216 2389010 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(2388216..2389010) Staphylococcus aureus subsp. aureus MRSA252 2861039 YP_041658.1 CDS SAR2303 NC_002952.2 2389015 2389821 R Similar to Bacillus subtilis hypothetical protein YbaF TR:P70972 (EMBL:Z99104) (265 aa) fasta scores: E(): 8.6e-45, 45.83% id in 264 aa, and to Streptococcus pyogenes hypothetical protein SPY2193 TR:Q99XI3 (EMBL:AE006636) (266 aa) fasta scores: E(): 1.5e-42, 42.04% id in 264 aa; cobalt transport protein complement(2389015..2389821) Staphylococcus aureus subsp. aureus MRSA252 2861040 YP_041659.1 CDS cbiO NC_002952.2 2389811 2390671 R with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2389811..2390671) Staphylococcus aureus subsp. aureus MRSA252 2861041 YP_041660.1 CDS cbiO NC_002952.2 2390668 2391477 R with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2390668..2391477) Staphylococcus aureus subsp. aureus MRSA252 2861042 YP_041661.1 CDS SAR2306 NC_002952.2 2391853 2392608 D C-terminal region is similar to Lactobacillus johnsonii insertion element IS1223 hypothetical protein SW:YI3A_LACJO (Q48585) (177 aa) fasta scores: E(): 2.7e-08, 33.140% id in 172 aa, and Mycoplasma mycoides insertion element IS1296 hypothetical protein SW:YI6A_MYCMY (Q50239) (180 aa) fasta scores: E(): 0.0092, 30.526% id in 190 aa; insertion element protein 2391853..2392608 Staphylococcus aureus subsp. aureus MRSA252 2861043 YP_041662.1 CDS SAR2307 NC_002952.2 2392632 2393420 D Similar to the C-terminal region of Enterococcus faecium transposase TR:Q47815 (EMBL:L40841) (310 aa) fasta scores: E(): 1.9e-39, 46.183% id in 262 aa, and to the full length Neisseria gonorrhoeae hypothetical protein TR:Q50996 (EMBL:L36381) (267 aa) fasta scores: E(): 1.1e-27, 39.689% id in 257 aa; transposase 2392632..2393420 Staphylococcus aureus subsp. aureus MRSA252 2861044 YP_041663.1 CDS rplQ NC_002952.2 2393673 2394041 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(2393673..2394041) Staphylococcus aureus subsp. aureus MRSA252 2860912 YP_041664.1 CDS rpoA NC_002952.2 2394058 2395002 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(2394058..2395002) Staphylococcus aureus subsp. aureus MRSA252 2860168 YP_041665.1 CDS rpsK NC_002952.2 2395077 2395466 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(2395077..2395466) Staphylococcus aureus subsp. aureus MRSA252 2861447 YP_041666.1 CDS rpsM NC_002952.2 2395490 2395855 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(2395490..2395855) Staphylococcus aureus subsp. aureus MRSA252 2861449 YP_041667.1 CDS rpmJ NC_002952.2 2395878 2395991 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(2395878..2395991) Staphylococcus aureus subsp. aureus MRSA252 2860167 YP_041668.1 CDS infA NC_002952.2 2396023 2396241 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(2396023..2396241) Staphylococcus aureus subsp. aureus MRSA252 2859667 YP_041669.1 CDS adk NC_002952.2 2396434 2397081 R essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(2396434..2397081) Staphylococcus aureus subsp. aureus MRSA252 2860980 YP_041670.1 CDS secY NC_002952.2 2397098 2398390 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(2397098..2398390) Staphylococcus aureus subsp. aureus MRSA252 2859137 YP_041671.1 CDS rplO NC_002952.2 2398390 2398830 R late assembly protein; 50S ribosomal protein L15 complement(2398390..2398830) Staphylococcus aureus subsp. aureus MRSA252 2860910 YP_041672.1 CDS rpmD NC_002952.2 2398847 2399026 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(2398847..2399026) Staphylococcus aureus subsp. aureus MRSA252 2860924 YP_041673.1 CDS rpsE NC_002952.2 2399043 2399543 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(2399043..2399543) Staphylococcus aureus subsp. aureus MRSA252 2860176 YP_041674.1 CDS rplR NC_002952.2 2399564 2399923 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(2399564..2399923) Staphylococcus aureus subsp. aureus MRSA252 2860913 YP_041675.1 CDS rplF NC_002952.2 2399954 2400490 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(2399954..2400490) Staphylococcus aureus subsp. aureus MRSA252 2860903 YP_041676.1 CDS rpsH NC_002952.2 2400515 2400913 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(2400515..2400913) Staphylococcus aureus subsp. aureus MRSA252 2860179 YP_041677.1 CDS rpsN NC_002952.2 2400945 2401130 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 complement(2400945..2401130) Staphylococcus aureus subsp. aureus MRSA252 2861450 YP_041678.1 CDS rplE NC_002952.2 2401153 2401692 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(2401153..2401692) Staphylococcus aureus subsp. aureus MRSA252 2860902 YP_041679.1 CDS rplX NC_002952.2 2401719 2402036 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(2401719..2402036) Staphylococcus aureus subsp. aureus MRSA252 2860919 YP_041680.1 CDS rplN NC_002952.2 2402072 2402440 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(2402072..2402440) Staphylococcus aureus subsp. aureus MRSA252 2860909 YP_041681.1 CDS rpsQ NC_002952.2 2402472 2402735 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(2402472..2402735) Staphylococcus aureus subsp. aureus MRSA252 2861453 YP_041682.1 CDS rpmC NC_002952.2 2402759 2402968 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(2402759..2402968) Staphylococcus aureus subsp. aureus MRSA252 2860923 YP_041683.1 CDS rplP NC_002952.2 2402958 2403392 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(2402958..2403392) Staphylococcus aureus subsp. aureus MRSA252 2860911 YP_041684.1 CDS rpsC NC_002952.2 2403395 2404048 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(2403395..2404048) Staphylococcus aureus subsp. aureus MRSA252 2860174 YP_041685.1 CDS rplV NC_002952.2 2404072 2404425 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(2404072..2404425) Staphylococcus aureus subsp. aureus MRSA252 2860917 YP_041686.1 CDS rpsS NC_002952.2 2404454 2404732 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(2404454..2404732) Staphylococcus aureus subsp. aureus MRSA252 2861455 YP_041687.1 CDS rplB NC_002952.2 2404799 2405632 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(2404799..2405632) Staphylococcus aureus subsp. aureus MRSA252 2860899 YP_041688.1 CDS rplW NC_002952.2 2405665 2405940 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(2405665..2405940) Staphylococcus aureus subsp. aureus MRSA252 2860918 YP_041689.1 CDS rplD NC_002952.2 2405940 2406563 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(2405940..2406563) Staphylococcus aureus subsp. aureus MRSA252 2860901 YP_041690.1 CDS rplC NC_002952.2 2406590 2407252 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(2406590..2407252) Staphylococcus aureus subsp. aureus MRSA252 2860900 YP_041691.1 CDS rpsJ NC_002952.2 2407280 2407588 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(2407280..2407588) Staphylococcus aureus subsp. aureus MRSA252 2861446 YP_041692.1 CDS SAR2337 NC_002952.2 2407939 2408334 D Poor database matches. Weakly similar to the C-terminal region of Lactococcus lactis hypothetical protein YkaC TR:Q9CGW4 (EMBL:AE006332) (213 aa) fasta scores: E(): 6.6, 28.28% id in 99 aa; hypothetical protein 2407939..2408334 Staphylococcus aureus subsp. aureus MRSA252 2861045 YP_041693.1 CDS SAR2338 NC_002952.2 2408527 2409861 R Similar to Bacillus subtilis hypothetical protein YebB TR:O34987 (EMBL:Z99107) (440 aa) fasta scores: E(): 2e-100, 64.48% id in 442 aa, and to Bacillus halodurans hypothetical protein BH0608 TR:Q9KF77 (EMBL:AP001509) (434 aa) fasta scores: E(): 5.3e-82, 58.4% id in 440 aa; xanthine/uracil permease complement(2408527..2409861) Staphylococcus aureus subsp. aureus MRSA252 2861046 YP_041694.1 CDS SAR2339 NC_002952.2 2409974 2412109 R decatenates replicating daughter chromosomes; DNA topoisomerase III complement(2409974..2412109) Staphylococcus aureus subsp. aureus MRSA252 2861047 YP_041695.1 CDS SAR2340 NC_002952.2 2412296 2413183 D Poor database matches. Weakly similar to Bacillus halodurans hypothetical protein BH0299 TR:Q9KG16 (EMBL:AP001508) (305 aa) fasta scores: E(): 1.5e-05, 19.72% id in 294 aa; acetyltransferase (GNAT) family protein 2412296..2413183 Staphylococcus aureus subsp. aureus MRSA252 2861048 YP_041696.1 CDS glcU NC_002952.2 2413364 2414227 D Similar to Staphylococcus xylosus glucose uptake protein GlcU TR:O07881 (EMBL:Y14043) (288 aa) fasta scores: E(): 4.6e-72, 72.53% id in 284 aa, and to Bacillus megaterium hypothetical protein SW:YCXE_BACME (P40419) (286 aa) fasta scores: E(): 2.1e-53, 54.06% id in 283 aa; glucose uptake protein 2413364..2414227 Staphylococcus aureus subsp. aureus MRSA252 2859918 YP_041697.1 CDS SAR2342 NC_002952.2 2414646 2415554 R Poor database matches. Similar to Methanococcus jannaschii hypothetical protein MJ1031 SW:YA31_METJA (Q58437) (308 aa) fasta scores: E(): 8.2e-09, 21.45% id in 317 aa, and to Clostridium cellulovorans malate permease Mln TR:Q9LAI9 (EMBL:AF132735) (290 aa) fasta scores: E(): 4.4e-06, 25.08% id in 287 aa; hypothetical protein complement(2414646..2415554) Staphylococcus aureus subsp. aureus MRSA252 2861049 YP_041698.1 CDS SAR2343 NC_002952.2 2415687 2415851 D Poor database matches. Similar to Bacillus halodurans hypothetical protein BH0180 TR:Q9KGC4 (EMBL:AP001507) (59 aa) fasta scores: E(): 7e-05, 46.15% id in 52 aa; hypothetical protein 2415687..2415851 Staphylococcus aureus subsp. aureus MRSA252 2861050 YP_041699.1 CDS SAR2344 NC_002952.2 2416096 2416413 D Poor database matches. Similar to the N-terminal region of Drosophila yakuba NADH-ubiquinone oxidoreductase chain 6 ND6 SW:NU6M_DROYA (P07709) (174 aa) fasta scores: E(): 2.3, 24.24% id in 99 aa; hypothetical protein 2416096..2416413 Staphylococcus aureus subsp. aureus MRSA252 2861051 YP_041700.1 CDS SAR2345 NC_002952.2 2416600 2419767 R Similar to Bacillus subtilis hypothetical protein YerP TR:O31501 (EMBL:Z99107) (1065 aa) fasta scores: E(): 1.2e-160, 46.03% id in 1058 aa, and to Bacillus halodurans cation efflux system protein BH3816 TR:Q9K6B3 (EMBL:AP001520) (1093 aa) fasta scores: E(): 2.4e-57, 26.52% id in 1063 aa; AcrB/AcrD/AcrF family protein complement(2416600..2419767) Staphylococcus aureus subsp. aureus MRSA252 2861052 YP_041701.1 CDS fmhB NC_002952.2 2419884 2421149 R Similar to Staphylococcus sciuri, peptidoglycan pentaglycine interpeptide biosynthesis protein, essential for methicillin resistance FemA TR:Q9ZFG3 (EMBL:AF099966) (417 aa) fasta scores: E(): 6.4e-20, 25.82% id in 426 aa. Previously sequenced as Staphylococcus aureus peptidoglycan pentaglycine interpeptide biosynthesis protein FmhB TR:Q9X4D7 (EMBL:AF106850) (421 aa) fasta scores: E(): 5.3e-150, 99.28% id in 421 aa; peptidoglycan pentaglycine interpeptide biosynthesis protein complement(2419884..2421149) Staphylococcus aureus subsp. aureus MRSA252 2860669 YP_041702.1 CDS SAR2347 NC_002952.2 2421538 2421789 D No significant database matches. Doubtful CDS; hypothetical protein 2421538..2421789 Staphylococcus aureus subsp. aureus MRSA252 2861053 YP_041703.1 CDS SAR2348 NC_002952.2 2421781 2422545 R Poor database matches. Similar to an internal region of Legionella pneumophila hypothetical protein TR:Q9AKW5 (EMBL:AJ277755) (402 aa) fasta scores: E(): 4.1, 20.07% id in 254 aa; hypothetical protein complement(2421781..2422545) Staphylococcus aureus subsp. aureus MRSA252 2861054 YP_041704.1 CDS SAR2349 NC_002952.2 2422708 2423148 D Similar to Escherichia coli homoprotocatechuate degradative operon repressor HpcR SW:HPCR_ECOLI (Q07095) (148 aa) fasta scores: E(): 0.0022, 21.42% id in 112 aa, and to Staphylococcus sciuri Orf141 protein TR:O54273 (EMBL:Y13094) (141 aa) fasta scores: E(): 0.00089, 23.94% id in 142 aa; MarR family regulatory protein 2422708..2423148 Staphylococcus aureus subsp. aureus MRSA252 2861055 YP_041705.1 CDS SAR2350 NC_002952.2 2423141 2424352 D Similar to Lactococcus lactis transporter YbfD TR:Q9CJ52 (EMBL:AE006253) (393 aa) fasta scores: E(): 1.3e-48, 37.08% id in 391 aa, and to Bacillus subtilis hypothetical protein YwoG TR:P94577 (EMBL:Z82987) (396 aa) fasta scores: E(): 6.8e-38, 32.19% id in 379 aa; transporter protein 2423141..2424352 Staphylococcus aureus subsp. aureus MRSA252 2861056 YP_041706.1 CDS SAR2351 NC_002952.2 2424454 2424804 R Similar to Staphylococcus aureus staphylococcal accessory regulator A SarA TR:Q53600 (EMBL:U20782) (124 aa) fasta scores: E(): 0.27, 27.83% id in 97 aa, and to Staphylococcus epidermidis staphylococcal accessory regulator A homologue SarA TR:O85233 (EMBL:AF054173) (124 aa) fasta scores: E(): 0.11, 26.88% id in 93 aa; hypothetical protein complement(2424454..2424804) Staphylococcus aureus subsp. aureus MRSA252 2861057 YP_041707.1 CDS moaA NC_002952.2 2425381 2426403 R Similar to Bacillus subtilis molybdenum cofactor biosynthesis protein A MoaA SW:MOAA_BACSU (P39757) (341 aa) fasta scores: E(): 4e-64, 49.85% id in 339 aa, and to Staphylococcus carnosus molybdenum cofactor biosynthesis protein A MoaA SW:MOAA_STACA (Q9ZIM6) (340 aa) fasta scores: E(): 7.7e-111, 83.82% id in 340 aa; molybdenum cofactor biosynthesis protein A complement(2425381..2426403) Staphylococcus aureus subsp. aureus MRSA252 2861173 YP_041708.1 CDS mobA NC_002952.2 2426423 2427022 R in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA complement(2426423..2427022) Staphylococcus aureus subsp. aureus MRSA252 2861299 YP_041709.1 CDS moaD NC_002952.2 2427029 2427262 R Similar to Homo sapiens molybdopterin-synthase small subunit MOCO1-B TR:O96033 (EMBL:AF091871) (88 aa) fasta scores: E(): 0.00015, 34.14% id in 82 aa, and to Staphylococcus carnosus MoaD protein TR:Q9ZIM8 (EMBL:AF109295) (77 aa) fasta scores: E(): 5.4e-15, 59.74% id in 77 aa; molybdopterin-synthase small subunit complement(2427029..2427262) Staphylococcus aureus subsp. aureus MRSA252 2861297 YP_041710.1 CDS moaE NC_002952.2 2427268 2427714 R Similar to Homo sapiens molybdopterin-synthase large subunit MOCO1-A TR:O96007 (EMBL:AF091871) (188 aa) fasta scores: E(): 1.2e-16, 40% id in 130 aa, and to Staphylococcus carnosus MoaE protein TR:Q9ZIM9 (EMBL:AF109295) (150 aa) fasta scores: E(): 4.1e-49, 84.72% id in 144 aa; molybdopterin-synthase large subunit complement(2427268..2427714) Staphylococcus aureus subsp. aureus MRSA252 2861298 YP_041711.1 CDS mobB NC_002952.2 2427728 2428213 R Similar to Escherichia coli molybdopterin-guanine dinucleotide biosynthesis protein B MobB SW:MOBB_ECOLI (P32125) (174 aa) fasta scores: E(): 0.00063, 27.96% id in 118 aa, and to Staphylococcus carnosus MobB protein TR:Q9ZIN0 (EMBL:AF109295) (160 aa) fasta scores: E(): 1.1e-29, 57.96% id in 157 aa; molybdopterin-guanine dinucleotide biosynthesis protein B complement(2427728..2428213) Staphylococcus aureus subsp. aureus MRSA252 2861300 YP_041712.1 CDS moeA NC_002952.2 2428210 2429469 R Similar to Clostridium perfringens molybdenum cofactor biosynthesis protein MoeA TR:Q9WX93 (EMBL:AB017192) (406 aa) fasta scores: E(): 9.7e-44, 36.25% id in 400 aa, and to Staphylococcus carnosus MoeA protein TR:Q9ZIN1 (EMBL:AF109295) (419 aa) fasta scores: E(): 1.5e-112, 74.7% id in 419 aa; molybdenum cofactor biosynthesis protein complement(2428210..2429469) Staphylococcus aureus subsp. aureus MRSA252 2861304 YP_041713.1 CDS moaC NC_002952.2 2429532 2430026 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 2429532..2430026 Staphylococcus aureus subsp. aureus MRSA252 2861296 YP_041714.1 CDS moaB NC_002952.2 2430028 2430534 R Similar to Escherichia coli molybdenum cofactor biosynthesis protein B MoaB SW:MOAB_ECOLI (P30746) (169 aa) fasta scores: E(): 4.4e-18, 44.59% id in 148 aa, and to Staphylococcus carnosus MoaB protein TR:Q9ZIN3 (EMBL:AF109295) (170 aa) fasta scores: E(): 9.2e-45, 77.1% id in 166 aa; molybdenum cofactor biosynthesis protein B complement(2430028..2430534) Staphylococcus aureus subsp. aureus MRSA252 2861174 YP_041715.1 CDS moeB NC_002952.2 2430563 2431567 R Similar to Staphylococcus carnosus molybdopterin synthase sulfurylase MoeB TR:Q9ZIN4 (EMBL:AF109295) (333 aa) fasta scores: E(): 3.9e-92, 68.58% id in 331 aa. N-terminal region to Escherichia coli adenylyltransferase ThiF SW:THIF_ECOLI (P30138) (251 aa) fasta scores: E(): 8e-18, 33.73% id in 249 aa; molybdopterin synthase sulfurylase complement(2430563..2431567) Staphylococcus aureus subsp. aureus MRSA252 2861305 YP_041716.1 CDS modC NC_002952.2 2431735 2432340 R Similar to the N-terminal region of Escherichia coli molybdenum transport ATP-binding protein ModC SW:MODC_ECOLI (P09833) (352 aa) fasta scores: E(): 2e-19, 38.61% id in 202 aa, and to the full length Staphylococcus carnosus ModC protein TR:Q9ZIN5 (EMBL:AF109295) (202 aa) fasta scores: E(): 2.9e-48, 74.62% id in 201 aa; molybdenum transport ATP-binding protein complement(2431735..2432340) Staphylococcus aureus subsp. aureus MRSA252 2861303 YP_041717.1 CDS modB NC_002952.2 2432341 2433012 R Similar to Escherichia coli molybdenum ABC transporter permease ModB SW:MODB_ECOLI (P09834) (229 aa) fasta scores: E(): 6.7e-21, 35.26% id in 207 aa, and to Staphylococcus carnosus ModB protein TR:Q9ZIN6 (EMBL:AF109295) (223 aa) fasta scores: E(): 7.9e-69, 81.16% id in 223 aa; molybdenum ABC transporter permease complement(2432341..2433012) Staphylococcus aureus subsp. aureus MRSA252 2861302 YP_041718.1 CDS modA NC_002952.2 2433026 2433808 R Similar to Rhodobacter capsulatus molybdate-binding periplasmic protein precursor ModA SW:MODA_RHOCA (Q08383) (252 aa) fasta scores: E(): 1.4e-08, 26.99% id in 226 aa, and to Staphylococcus carnosus ModA protein TR:Q9ZIN7 (EMBL:AF109295) (261 aa) fasta scores: E(): 4.4e-60, 69.61% id in 260 aa; molybdate-binding lipoprotein precursor complement(2433026..2433808) Staphylococcus aureus subsp. aureus MRSA252 2861301 YP_041719.1 CDS SAR2364 NC_002952.2 2434098 2434895 D involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 2434098..2434895 Staphylococcus aureus subsp. aureus MRSA252 2861058 YP_041720.1 CDS SAR2365 NC_002952.2 2435066 2435836 R Poor database matches. Weakly similar to Bacillus subtilis hypothetical protein that possibly influences maturation of the outermost layer of the spore, CgeE SW:CGEE_BACSU (P42093) (259 aa) fasta scores: E(): 0.65, 20.96% id in 229 aa; acetyltransferase (GNAT) family protein complement(2435066..2435836) Staphylococcus aureus subsp. aureus MRSA252 2861059 YP_041721.1 CDS SAR2366 NC_002952.2 2435908 2436462 R Similar to Bacillus sphaericus biotin synthase BioY SW:BIOY_BACSH (P22819) (196 aa) fasta scores: E(): 1.2e-07, 30% id in 180 aa, and to Lactococcus lactis hypothetical protein YseA TR:Q9CEQ5 (EMBL:AE006408) (189 aa) fasta scores: E(): 8.6e-21, 43.75% id in 176 aa; BioY family protein complement(2435908..2436462) Staphylococcus aureus subsp. aureus MRSA252 2861060 YP_041722.1 CDS SAR2367 NC_002952.2 2436583 2437524 R Similar to Trypanosoma brucei brucei inosine-adenosine-guanosine-nucleoside hydrolase TR:O15727 (EMBL:AF017231) (327 aa) fasta scores: E(): 2.8e-16, 31.28% id in 326 aa, and to Trypanosoma vivax iag-nucleoside hydrolase TR:Q9GPQ4 (EMBL:AF311701) (327 aa) fasta scores: E(): 7.3e-18, 31.9% id in 326 aa; inosine-uridine preferring nucleoside hydrolase complement(2436583..2437524) Staphylococcus aureus subsp. aureus MRSA252 2861061 YP_041723.1 CDS SAR2368 NC_002952.2 2437923 2438831 R Similar to Bacillus subtilis ferrichrome-binding protein precursor FhuD SW:FHUD_BACSU (P37580) (315 aa) fasta scores: E(): 1.1e-31, 37.82% id in 312 aa, and to Streptococcus pyogenes ferrichrome ABC transporter SPY0385 TR:Q9A198 (EMBL:AE006501) (310 aa) fasta scores: E(): 8.4e-34, 37.74% id in 310 aa; ferrichrome-binding lipoprotein precursor complement(2437923..2438831) Staphylococcus aureus subsp. aureus MRSA252 2861062 YP_041724.1 CDS SAR2369 NC_002952.2 2439044 2440198 R Similar to Clostridium acetobutylicum short-chain specific acyl-CoA dehydrogenase Bcd SW:ACDS_CLOAB (P52042) (379 aa) fasta scores: E(): 7.5e-14, 22.4% id in 366 aa, and to Bacillus subtilis hypothetical protein YdbM TR:P96608 (EMBL:AB001488) (381 aa) fasta scores: E(): 9.4e-71, 48.93% id in 374 aa; hypothetical protein complement(2439044..2440198) Staphylococcus aureus subsp. aureus MRSA252 2861063 YP_041725.1 CDS SAR2370 NC_002952.2 2440245 2440337 R Doubtful CDS. No significant database matches; hypothetical protein complement(2440245..2440337) Staphylococcus aureus subsp. aureus MRSA252 2861064 YP_041726.1 CDS SAR2371 NC_002952.2 2440413 2441318 R Similar to internal regions of Homo sapiens erythrocyte urea transporter UT1 SW:UT1_HUMAN (Q13336) (389 aa) fasta scores: E(): 7.2e-17, 27.15% id in 302 aa, and Oryctolagus cuniculus kidney urea transporter UT2 SW:UT2_RABIT (Q28614) (397 aa) fasta scores: E(): 1.2e-15, 26.78% id in 295 aa; hypothetical protein complement(2440413..2441318) Staphylococcus aureus subsp. aureus MRSA252 2859823 YP_041727.1 CDS ureA NC_002952.2 2441578 2441880 D UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 2441578..2441880 Staphylococcus aureus subsp. aureus MRSA252 2860416 YP_041728.1 CDS ureB NC_002952.2 2441894 2442304 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Staphylococcus saprophyticus plays a role in bladder invasiveness and may induce the formation of kidney and bladder stones due to the alkalization of urine; urease subunit beta 2441894..2442304 Staphylococcus aureus subsp. aureus MRSA252 2860417 YP_041729.1 CDS ureC NC_002952.2 2442301 2444016 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 2442301..2444016 Staphylococcus aureus subsp. aureus MRSA252 2860418 YP_041730.1 CDS ureE NC_002952.2 2444029 2444481 D involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 2444029..2444481 Staphylococcus aureus subsp. aureus MRSA252 2860420 YP_041731.1 CDS ureF NC_002952.2 2444474 2445163 D Similar to Bacillus sp urease accessory protein UreF SW:UREF_BACSB (Q07402) (227 aa) fasta scores: E(): 3.5e-39, 44.39% id in 223 aa. N-terminus is similar to Staphylococcus xylosus urease accessory protein UreF SW:UREF_STAXY (P42876) (189 aa) fasta scores: E(): 3.9e-61, 78.19% id in 188 aa; urease accessory protein UreF 2444474..2445163 Staphylococcus aureus subsp. aureus MRSA252 2860421 YP_041732.1 CDS ureG NC_002952.2 2445176 2445790 D Similar to Staphylococcus xylosus urease accessory protein UreG SW:UREG_STAXY (P42877) (204 aa) fasta scores: E(): 2.1e-63, 89.7% id in 204 aa, and to Bacillus sp urease accessory protein UreG SW:UREG_BACSB (Q07403) (204 aa) fasta scores: E(): 8.1e-52, 75% id in 200 aa; urease accessory protein UreG 2445176..2445790 Staphylococcus aureus subsp. aureus MRSA252 2860422 YP_041733.1 CDS ureD NC_002952.2 2445790 2446626 D Similar to Bacillus sp urease accessory protein UreD SW:URED_BACSB (Q07400) (271 aa) fasta scores: E(): 1.8e-32, 34.19% id in 272 aa, and to Ureaplasma urealyticum urease complex component UreD TR:Q9FA29 (EMBL:AF085731) (287 aa) fasta scores: E(): 2.4e-26, 29.13% id in 278 aa; urease accessory protein UreD 2445790..2446626 Staphylococcus aureus subsp. aureus MRSA252 2860419 YP_041734.1 CDS sarR NC_002952.2 2446815 2447162 R Similar to Staphylococcus aureus staphylococcal accessory regulator A SarA TR:Q53600 (EMBL:U20782) (124 aa) fasta scores: E(): 1.9e-05, 30.08% id in 113 aa. Previously sequenced as Staphylococcus aureus taphylococcal accessory regulator A homologue SarR TR:Q9F0R1 (EMBL:AF207701) (115 aa) fasta scores: E(): 2.5e-37, 100% id in 115 aa; accessory regulator A complement(2446815..2447162) Staphylococcus aureus subsp. aureus MRSA252 2861467 YP_041735.1 CDS SAR2380 NC_002952.2 2447590 2447916 R Poor database matches. Similar to Staphylococcus xylosus hypothetical protein TR:Q9EV51 (EMBL:AJ295151) (108 aa) fasta scores: E(): 2.2e-22, 55.76% id in 104 aa; hypothetical protein complement(2447590..2447916) Staphylococcus aureus subsp. aureus MRSA252 2858996 YP_041736.1 CDS SAR2381 NC_002952.2 2447980 2448723 R Poor database matches. N-terminal region is similar to Staphylococcus aureus staphylococcal accessory regulator A homologue SarR TR:Q9F0R1 (EMBL:AF207701) (115 aa) fasta scores: E(): 3, 24.57% id in 118 aa. Similar to the full length Staphylococcus aureus rot-like protein Rlp TR:Q9EZK4 (EMBL:AF288788) (247 aa) fasta scores: E(): 0.41, 25.84% id in 236 aa; hypothetical protein complement(2447980..2448723) Staphylococcus aureus subsp. aureus MRSA252 2858997 YP_041737.1 CDS SAR2382 NC_002952.2 2448749 2450704 R No significant database matches to the full length CDS. N-terminus is similar to Bacillus halodurans transcriptional regulator BH0711 TR:Q9KEY8 (EMBL:AP001509) (263 aa) fasta scores: E(): 0.018, 22.43% id in 263 aa, and Lactococcus lactis xylose regulatory protein XylR TR:Q9RAV4 (EMBL:AF092040) (316 aa) fasta scores: E(): 0.024, 20.35% id in 285 aa; transcriptional regulator complement(2448749..2450704) Staphylococcus aureus subsp. aureus MRSA252 2858998 YP_041738.1 CDS SAR2383 NC_002952.2 2451314 2452123 D Similar to Staphylococcus carnosus major secreted protein SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 2.3e-57, 65.81% id in 275 aa, and to Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 6.3e-48, 72.89% id in 273 aa. Similar to SAR2648, 75.093% identity (79.216% ungapped) in 269 aa overlap. C-terminal region is similar to SAR2388, 63.077% identity (65.079% ungapped) in 130 aa overlap; hypothetical protein 2451314..2452123 Staphylococcus aureus subsp. aureus MRSA252 2858999 YP_041739.1 CDS SAR2384 NC_002952.2 2452192 2452386 R Doubtful CDS. No significant database matches; hypothetical protein complement(2452192..2452386) Staphylococcus aureus subsp. aureus MRSA252 2859000 YP_041740.1 CDS SAR2385 NC_002952.2 2452560 2453960 R Similar to Bacillus firmus Na+/H+ antiporter NhaC SW:NHAC_BACFI (P27611) (462 aa) fasta scores: E(): 4.8e-47, 31.25% id in 464 aa, and to Haemophilus influenzae hypothetical Na+/H+ antiporter HI1107 SW:YB07_HAEIN (Q57007) (468 aa) fasta scores: E(): 1.5e-63, 36.16% id in 459 aa; Na+/H+ antiporter complement(2452560..2453960) Staphylococcus aureus subsp. aureus MRSA252 2859001 YP_041741.1 CDS SAR2386 NC_002952.2 2454055 2455137 R Similar to Arthrobacter sp opine dehydrogenase Odh SW:ODH_ARTSP (Q44297) (359 aa) fasta scores: E(): 1.4e-22, 26.68% id in 356 aa, and to Agrobacterium vitis vitopine synthase Vis SW:VIS_AGRVI (Q04554) (360 aa) fasta scores: E(): 4.6e-10, 24.15% id in 356 aa; dehydrogenase complement(2454055..2455137) Staphylococcus aureus subsp. aureus MRSA252 2859002 YP_041742.1 CDS SAR2387 NC_002952.2 2455385 2455807 D Poor database matches. Weak similarity to Pseudomonas aeruginosa hypothetical protein PA5333 TR:Q9HTM4 (EMBL:AE004946) (123 aa) fasta scores: E(): 0.0059, 30.28% id in 142 aa, and to Synechocystis sp hypothetical protein SLR0686 TR:P72954 (EMBL:D90902) (119 aa) fasta scores: E(): 7e-05, 35.29% id in 136 aa; hypothetical protein 2455385..2455807 Staphylococcus aureus subsp. aureus MRSA252 2859003 YP_041743.1 CDS SAR2388 NC_002952.2 2456044 2456535 D Similar to the C-terminal regions of Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 1.5e-27, 59.12% id in 137 aa, andStaphylococcus carnosus major secreted protein SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 1.8e-27, 58.08% id in 136 aa. Similar to the C-terminal regions of SAR2383, 63.077% identity (65.079% ungapped) in 130 aa overlap, and SAR2648, 60.769% identity (62.698% ungapped) in 130 aa overlap; hypothetical protein 2456044..2456535 Staphylococcus aureus subsp. aureus MRSA252 2859004 YP_041744.1 CDS SAR2389 NC_002952.2 2456894 2457847 D Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; glycerate dehydrogenase 2456894..2457847 Staphylococcus aureus subsp. aureus MRSA252 2859005 YP_041745.1 CDS SAR2390 NC_002952.2 2457939 2459063 R Similar to Streptomyces coelicolor monooxygenase 2SCG61.20c TR:Q9K3Z5 (EMBL:AL359949) (396 aa) fasta scores: E(): 1.9e-22, 29.58% id in 365 aa, and to Pseudomonas aeruginosa probable FAD-dependent monooxygenase PA3328 TR:Q9HYR7 (EMBL:AE004755) (388 aa) fasta scores: E(): 2.4e-20, 25.72% id in 381 aa; hypothetical protein complement(2457939..2459063) Staphylococcus aureus subsp. aureus MRSA252 2859006 YP_041746.1 CDS SAR2391 NC_002952.2 2459728 2460504 R Similar to the C-terminal regions of Staphylococcus aureus bifunctional autolysin precursor [includes: N-acetylmuramoyl-L-alanine amidase; mannosyl-glycoprotein endo-beta-N-acetylglucosamidase] Atl SW:ATL_STAAU (P52081) (1256 aa) fasta scores: E(): 1.8e-24, 39.55% id in 225 aa, and Bacillus subtilis beta-N-acetylglucosaminidase precursor LytD SW:LYTD_BACSU (P39848) (880 aa) fasta scores: E(): 8.3e-22, 43.24% id in 185 aa; N-acetylmuramoyl-L-alanine amidase complement(2459728..2460504) Staphylococcus aureus subsp. aureus MRSA252 2859007 YP_041747.1 CDS SAR2391a NC_002952.2 2460526 2460777 R hypothetical protein complement(2460526..2460777) Staphylococcus aureus subsp. aureus MRSA252 2859008 YP_041748.1 CDS SAR2392 NC_002952.2 2461053 2461526 R Similar to Bacillus subtilis hypothetical protein YrhD SW:YRHD_BACSU (O05396) (160 aa) fasta scores: E(): 2.9e-07, 28.66% id in 157 aa, and to Bacillus subtilis hypothetical protein YjgD TR:O34681 (EMBL:AF015825) (186 aa) fasta scores: E(): 3.5e-06, 26.11% id in 157 aa; hypothetical protein complement(2461053..2461526) Staphylococcus aureus subsp. aureus MRSA252 2859009 YP_041749.1 CDS SAR2393 NC_002952.2 2461526 2464480 R C-terminal region is similar to Escherichia coli formate dehydrogenase H FdhF SW:FDHF_ECOLI (P07658) (715 aa) fasta scores: E(): 2.7e-78, 35.15% id in 697 aa. Full length CDS similar to Bacillus subtilis formate dehydrogenase alpha subunit homologue YjgC TR:O34720 (EMBL:AF015825) (985 aa) fasta scores: E(): 0, 59.34% id in 979 aa; bifunctional protein GlmU complement(2461526..2464480) Staphylococcus aureus subsp. aureus MRSA252 2859010 YP_041750.1 CDS SAR2394 NC_002952.2 2465082 2466029 R Similar to Bacillus subtilis membrane-bound attenuator of lytABC and lytR expression LytR SW:LYTR_BACSU (Q02115) (306 aa) fasta scores: E(): 1.5e-40, 40% id in 315 aa, and to Bacillus halodurans attenuator of lytABC and lytR expression BH3670 TR:Q9K6Q8 (EMBL:AP001519) (304 aa) fasta scores: E(): 3.3e-38, 37.91% id in 298 aa; hypothetical protein complement(2465082..2466029) Staphylococcus aureus subsp. aureus MRSA252 2859011 YP_041751.1 CDS SAR2395 NC_002952.2 2466162 2466959 R Similar to Escherichia coli extragenic suppressor protein SuhB SW:SUHB_ECOLI (P22783) (267 aa) fasta scores: E(): 1.8e-13, 28.19% id in 227 aa, and to Bacillus subtilis extragenic suppressor protein SuhB homologue SW:SUHB_BACSU (Q45499) (265 aa) fasta scores: E(): 8.2e-21, 30.76% id in 260 aa; inositol monophosphatase complement(2466162..2466959) Staphylococcus aureus subsp. aureus MRSA252 2859012 YP_041752.1 CDS SAR2396 NC_002952.2 2467344 2468036 D Similar to the N-terminal regions of Bacillus halodurans BH1889 TR:Q9KBN6 (EMBL:AP001513) (325 aa) fasta scores: E(): 5.9e-11, 23.47% id in 230 aa, and to Bacillus subtilis transcription regulator YobV TR:O34920 (EMBL:AF027868) (313 aa) fasta scores: E(): 0.0019, 22.76% id in 224 aa; DeoR family regulatory protein 2467344..2468036 Staphylococcus aureus subsp. aureus MRSA252 2859013 YP_041753.1 CDS SAR2397 NC_002952.2 2468061 2468798 R Poor database matches. Similar to Bacillus anthracis plasmid pXO2 hypothetical protein pXO2-46 TR:Q9RMY6 (EMBL:AF188935) (221 aa) fasta scores: E(): 2.7e-07, 28.11% id in 217 aa, and to Bacillus halodurans hypothetical protein BH0560 TR:Q9KFC4 (EMBL:AP001508) (237 aa) fasta scores: E(): 1.9e-06, 26% id in 223 aa; hypothetical protein complement(2468061..2468798) Staphylococcus aureus subsp. aureus MRSA252 2859014 YP_041754.1 CDS SAR2398 NC_002952.2 2468847 2469176 D Poor database matches. Similar to an internal region of Mycoplasma mycoides subsp. mycoides glycerol transporter subunit A GtsA TR:Q9F0F4 (EMBL:AF251037) (406 aa) fasta scores: E(): 4, 29.09% id in 110 aa; hypothetical protein 2468847..2469176 Staphylococcus aureus subsp. aureus MRSA252 2859015 YP_041755.1 CDS SAR2399 NC_002952.2 2469621 2470493 D Similar to Lactococcus lactis transcription regulator YleF TR:Q9CGG3 (EMBL:AE006345) (283 aa) fasta scores: E(): 3.6e-25, 31.15% id in 276 aa, and to Thermotoga maritima hypothetical protein TM0326 SW:Y326_THEMA (Q9WYG1) (280 aa) fasta scores: E(): 3.8e-19, 27.85% id in 280 aa. Similar to SAR0194, 54.639% identity (54.828% ungapped) in 291 aa overlap; transcriptional regulator 2469621..2470493 Staphylococcus aureus subsp. aureus MRSA252 2859016 YP_041756.1 CDS SAR2400 NC_002952.2 2470876 2472255 R Similar to Salmonella typhimurium proline-specific permease ProY SW:PROY_SALTY (P37460) (456 aa) fasta scores: E(): 4.9e-75, 46.05% id in 456 aa, and to Bacillus subtilis hypothetical transport protein YbxG SW:YBXG_BACSU (P54425) (462 aa) fasta scores: E(): 8.1e-113, 68.81% id in 449 aa; amino acid permease complement(2470876..2472255) Staphylococcus aureus subsp. aureus MRSA252 2859017 YP_041757.1 CDS SAR2401 NC_002952.2 2472535 2472891 D Poor database matches; hypothetical protein 2472535..2472891 Staphylococcus aureus subsp. aureus MRSA252 2859018 YP_041758.1 CDS SAR2402 NC_002952.2 2472888 2473073 D Poor database matches. Similar to Streptococcus pneumoniae hypothetical protein Orf24 TR:Q9EZG8 (EMBL:AF295925) (77 aa) fasta scores: E(): 9.8, 35.59% id in 59 aa; hypothetical protein 2472888..2473073 Staphylococcus aureus subsp. aureus MRSA252 2859019 YP_041759.1 CDS SAR2403 NC_002952.2 2473169 2473360 R Poor database matches; hypothetical protein complement(2473169..2473360) Staphylococcus aureus subsp. aureus MRSA252 2859020 YP_041760.1 CDS SAR2404 NC_002952.2 2473371 2474006 R Similar to Bacillus subtilis hypothetical protein YhcW SW:YHCW_BACSU (P54607) (220 aa) fasta scores: E(): 6.1e-15, 33.83% id in 201 aa, and to Deinococcus radiodurans CbbY/CbbZ/GpH/YieH family hydrolase DR2613 TR:Q9RR83 (EMBL:AE002090) (238 aa) fasta scores: E(): 4.3e-15, 34.73% id in 190 aa; haloacid dehalogenase-like hydrolase complement(2473371..2474006) Staphylococcus aureus subsp. aureus MRSA252 2859021 YP_041761.1 CDS SAR2407 NC_002952.2 2475266 2475796 D hypothetical protein 2475266..2475796 Staphylococcus aureus subsp. aureus MRSA252 2859023 YP_041762.1 CDS SAR2408 NC_002952.2 2475862 2477466 R Similar to Bacillus subtilis PTS system, arbutin-like IIBC component GlvC SW:PTIB_BACSU (P54715) (527 aa) fasta scores: E(): 2.4e-119, 56.43% id in 528 aa, and to Escherichia coli PTS system, arbutin-like IIC component GlvC SW:PTIC_ECOLI (P31452) (368 aa) fasta scores: E(): 2e-77, 55.31% id in 367 aa; PTS system, arbutin-like IIBC component complement(2475862..2477466) Staphylococcus aureus subsp. aureus MRSA252 2859024 YP_041763.1 CDS SAR2409 NC_002952.2 2477797 2478561 D Similar to Bacillus subtilis hypothetical protein YfiA SW:YFIA_BACSU (P54717) (254 aa) fasta scores: E(): 1e-26, 35.77% id in 246 aa, and to Bacillus halodurans hypothetical protein BH0181 TR:Q9KGC3 (EMBL:AP001507) (241 aa) fasta scores: E(): 2.3e-09, 28.34% id in 247 aa; transcriptional regulator 2477797..2478561 Staphylococcus aureus subsp. aureus MRSA252 2859025 YP_041764.1 CDS SAR2410 NC_002952.2 2478619 2479125 R hypothetical protein complement(2478619..2479125) Staphylococcus aureus subsp. aureus MRSA252 2859026 YP_041765.1 CDS SAR2411 NC_002952.2 2479295 2480671 R Similar to Bacillus firmus Na+/H+ antiporter NhaC SW:NHAC_BACFI (P27611) (462 aa) fasta scores: E(): 3.9e-07, 25.39% id in 449 aa, and to Vibrio cholerae Na+/H+ antiporter VCA0193 TR:Q9KMX3 (EMBL:AE004359) (447 aa) fasta scores: E(): 5.4e-60, 43.54% id in 434 aa. Possible alternative translational start site; transporter complement(2479295..2480671) Staphylococcus aureus subsp. aureus MRSA252 2859027 YP_041766.1 CDS SAR2412 NC_002952.2 2480830 2481399 R hypothetical protein complement(2480830..2481399) Staphylococcus aureus subsp. aureus MRSA252 2859028 YP_041767.1 CDS SAR2413 NC_002952.2 2481886 2482767 R Similar to Bacillus subtilis hypothetical oxidoreductase YhxD SW:YHXD_BACSU (P40398) (299 aa) fasta scores: E(): 1.1e-63, 60.9% id in 289 aa, and to Escherichia coli hypothetical oxidoreductase YghA TR:AAG58139 (EMBL:U28377) (294 aa) fasta scores: E(): 5.5e-63, 59.79% id in 286 aa; short chain dehydrogenase complement(2481886..2482767) Staphylococcus aureus subsp. aureus MRSA252 2859029 YP_041768.1 CDS hutI NC_002952.2 2484274 2485512 R catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; imidazolonepropionase complement(2484274..2485512) Staphylococcus aureus subsp. aureus MRSA252 2859651 YP_041769.1 CDS hutU NC_002952.2 2485512 2487173 R catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism; urocanate hydratase complement(2485512..2487173) Staphylococcus aureus subsp. aureus MRSA252 2859652 YP_041770.1 CDS SAR2418 NC_002952.2 2487333 2488217 D Similar to Bacillus subtilis als operon regulatory protein AlsR SW:ALSR_BACSU (Q04778) (302 aa) fasta scores: E(): 9.3e-14, 24.15% id in 294 aa, and to Bacillus halodurans transcriptional regulator BH3925 TR:Q9K610 (EMBL:AP001520) (289 aa) fasta scores: E(): 2.5e-14, 25.51% id in 290 aa; LysR family regulatory protein 2487333..2488217 Staphylococcus aureus subsp. aureus MRSA252 2859031 YP_041771.1 CDS fosB NC_002952.2 2488459 2488878 D catalyzes resistance to fosfomycin by the addition of a thiol cofactor; fosfomycin resistance protein FosB 2488459..2488878 Staphylococcus aureus subsp. aureus MRSA252 2860680 YP_041772.1 CDS SAR2420 NC_002952.2 2489134 2490069 R catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate; formimidoylglutamase complement(2489134..2490069) Staphylococcus aureus subsp. aureus MRSA252 2859032 YP_041773.1 CDS SAR2421 NC_002952.2 2490347 2491606 D hypothetical protein 2490347..2491606 Staphylococcus aureus subsp. aureus MRSA252 2859033 YP_041774.1 CDS SAR2422 NC_002952.2 2491672 2492358 R catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(2491672..2492358) Staphylococcus aureus subsp. aureus MRSA252 2859034 YP_041775.1 CDS SAR2423 NC_002952.2 2492529 2493182 D Similar to Bacillus subtilis hypothetical protein YflK TR:O34542 (EMBL:Z99108) (221 aa) fasta scores: E(): 3.9e-22, 35.81% id in 215 aa, and to Escherichia coli hypothetical protein YiiM SW:YIIM_ECOLI (P32157) (234 aa) fasta scores: E(): 8e-19, 34.13% id in 208 aa; hypothetical protein 2492529..2493182 Staphylococcus aureus subsp. aureus MRSA252 2859035 YP_041776.1 CDS SAR2424 NC_002952.2 2493418 2494437 R Similar to Haemophilus influenzae aldose 1-epimerase GalM SW:GALM_HAEIN (P31765) (340 aa) fasta scores: E(): 1.8e-17, 29.76% id in 336 aa, and to Lactococcus lactis aldose 1-epimerase GalM TR:Q9CE62 (EMBL:AE006428) (339 aa) fasta scores: E(): 5.1e-32, 34.09% id in 349 aa; aldose 1-epimerase complement(2493418..2494437) Staphylococcus aureus subsp. aureus MRSA252 2859036 YP_041777.1 CDS SAR2425 NC_002952.2 2494467 2494793 R Similar to Bacillus halodurans hypothetical protein BH2744 TR:Q9K9A5 (EMBL:AP001516) (108 aa) fasta scores: E(): 7.1e-23, 61.68% id in 107 aa, and to Bacillus subtilis hypothetical protein YfjF SW:YFJF_BACSU (O31553) (109 aa) fasta scores: E(): 1.1e-22, 57.94% id in 107 aa; hypothetical protein complement(2494467..2494793) Staphylococcus aureus subsp. aureus MRSA252 2859037 YP_041778.1 CDS SAR2426 NC_002952.2 2495011 2496243 R Similar to Bacillus subtilis hypothetical protein YhaP SW:YHAP_BACSU (O07523) (419 aa) fasta scores: E(): 3.9e-36, 32.93% id in 419 aa, and to Bacillus firmus hypothetical protein NatB TR:O87565 (EMBL:AF084104) (420 aa) fasta scores: E(): 3.3e-27, 27.99% id in 418 aa; hypothetical protein complement(2495011..2496243) Staphylococcus aureus subsp. aureus MRSA252 2859350 YP_041779.1 CDS SAR2427 NC_002952.2 2496236 2497135 R Similar to Bacillus firmus hypothetical protein NatA TR:O87564 (EMBL:AF084104) (299 aa) fasta scores: E(): 2.5e-53, 58.3% id in 295 aa, and to Bacillus halodurans ABC transporter BH1166 TR:Q9KDP5 (EMBL:AP001511) (299 aa) fasta scores: E(): 1.8e-52, 55.89% id in 297 aa; ABC transporter ATP-binding protein complement(2496236..2497135) Staphylococcus aureus subsp. aureus MRSA252 2859351 YP_041780.1 CDS SAR2428 NC_002952.2 2497368 2498015 R Poor database matches. N-terminus is weakly similar to Streptococcus thermophilus cysteine aminopeptidase PepC TR:Q56116 (EMBL:Z30315) (146 aa) fasta scores: E(): 0.0053, 27.06% id in 133 aa; hypothetical protein complement(2497368..2498015) Staphylococcus aureus subsp. aureus MRSA252 2859352 YP_041781.1 CDS SAR2428a NC_002952.2 2498007 2498129 D Doubtful CDS; hypothetical protein 2498007..2498129 Staphylococcus aureus subsp. aureus MRSA252 2859353 YP_041782.1 CDS SAR2428b NC_002952.2 2498195 2498326 D Doubtful CDS; hypothetical protein 2498195..2498326 Staphylococcus aureus subsp. aureus MRSA252 2859354 YP_041783.1 CDS SAR2429 NC_002952.2 2498414 2499022 D Similar to Arabidopsis thaliana DNA-3-methyladenine glycosylase MAG SW:3MG_ARATH (Q39147) (254 aa) fasta scores: E(): 5.8e-08, 29.31% id in 191 aa, and to Bacillus subtilis 3-methyladenine DNA glycosylase YxlJ SW:3MGH_BACSU (P94378) (196 aa) fasta scores: E(): 1.3e-22, 39.68% id in 189 aa; 3-methylpurine glycosylase 2498414..2499022 Staphylococcus aureus subsp. aureus MRSA252 2859355 YP_041784.1 CDS SAR2430 NC_002952.2 2499358 2500566 D Similar to Escherichia coli sodium/glutamate symport carrier protein GltS SW:GLTS_ECOLI (P19933) (401 aa) fasta scores: E(): 1.9e-48, 39.14% id in 396 aa, and to Pseudomonas aeruginosa sodium/glutamate symporter PA3176 TR:Q9HZ58 (EMBL:AE004741) (404 aa) fasta scores: E(): 3.2e-55, 41.19% id in 403 aa; permease 2499358..2500566 Staphylococcus aureus subsp. aureus MRSA252 2859356 YP_041785.1 CDS fni NC_002952.2 2500614 2501663 R catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase complement(2500614..2501663) Staphylococcus aureus subsp. aureus MRSA252 2860674 YP_041786.1 CDS SAR2432 NC_002952.2 2501694 2502641 R Similar to Bacillus subtilis hypothetical protein YfjQ TR:O31543 (EMBL:Z99108) (319 aa) fasta scores: E(): 1.1e-29, 33.1% id in 296 aa, and to Rhizobium loti divalent cation transport-related protein MLR5559 TR:BAB51987 (EMBL:AP003006) (364 aa) fasta scores: E(): 1e-18, 28.88% id in 322 aa; CorA-like Mg2+ transporter protein complement(2501694..2502641) Staphylococcus aureus subsp. aureus MRSA252 2859357 YP_041787.1 CDS SAR2433 NC_002952.2 2502738 2503229 D Similar to Rhizobium loti hypothetical protein MLR1489 TR:BAB48851 (EMBL:AP002997) (159 aa) fasta scores: E(): 2.3e-09, 25.15% id in 159 aa, and to Pseudomonas aeruginosa hypothetical protein PA5385 TR:Q9HTH9 (EMBL:AE004951) (159 aa) fasta scores: E(): 2.4e-08, 27.56% id in 156 aa; hypothetical protein 2502738..2503229 Staphylococcus aureus subsp. aureus MRSA252 2859358 YP_041788.1 CDS SAR2434 NC_002952.2 2503226 2503645 D Poor database matches. C-terminal region is similar to Bacillus subtilis plasmid pLS32 hypothetical protein TR:O52943 (EMBL:D49467) (98 aa) fasta scores: E(): 0.31, 30% id in 90 aa; hypothetical protein 2503226..2503645 Staphylococcus aureus subsp. aureus MRSA252 2859359 YP_041789.1 CDS SAR2435 NC_002952.2 2503753 2504673 R Similar to Streptomyces hygroscopicus acetyl-hydrolase Bah SW:BAH_STRHY (Q01109) (299 aa) fasta scores: E(): 4.3e-08, 26.99% id in 226 aa, and to Rhizobium loti esterase MLR1247 TR:BAB48665 (EMBL:AP002997) (317 aa) fasta scores: E(): 6.1e-21, 27.05% id in 292 aa; hypothetical protein complement(2503753..2504673) Staphylococcus aureus subsp. aureus MRSA252 2859360 YP_041790.1 CDS SAR2436 NC_002952.2 2504881 2505519 D hypothetical protein 2504881..2505519 Staphylococcus aureus subsp. aureus MRSA252 2859361 YP_041791.1 CDS SAR2437 NC_002952.2 2505765 2507702 R C-terminal region is similar to Escherichia coli multidrug resistance protein B EmrB SW:EMRB_ECOLI (P27304) (512 aa) fasta scores: E(): 1e-33, 29.5% id in 488 aa, and Bacillus subtilis hypothetical transport protein YhcA SW:YHCA_BACSU (P54585) (532 aa) fasta scores: E(): 1e-73, 46.81% id in 502 aa. CDS appears to have an extended N-terminus in comparsion to orthologues; transporter complement(2505765..2507702) Staphylococcus aureus subsp. aureus MRSA252 2859362 YP_041792.1 CDS SAR2438 NC_002952.2 2507715 2508362 R Similar to Bacillus subtilis hypothetical protein YhbJ TR:O31593 (EMBL:Z99108) (221 aa) fasta scores: E(): 7.9e-27, 45.02% id in 211 aa, and to the C-terminal region of Rhizobium etli transport protein RmrA TR:Q9KIH4 (EMBL:AF233286) (396 aa) fasta scores: E(): 9e-08, 30.5% id in 200 aa; hypothetical protein complement(2507715..2508362) Staphylococcus aureus subsp. aureus MRSA252 2859363 YP_041793.1 CDS SAR2439 NC_002952.2 2508483 2509037 D Similar to Bacillus halodurans transcriptional regulator BH0719 TR:Q9KEY0 (EMBL:AP001509) (188 aa) fasta scores: E(): 1.1e-08, 28.8% id in 184 aa, and to Streptococcus pyogenes transcriptional regulator SPY2177 TR:Q99XJ5 (EMBL:AE006635) (177 aa) fasta scores: E(): 7e-05, 26.4% id in 178 aa; TetR family regulatory protein 2508483..2509037 Staphylococcus aureus subsp. aureus MRSA252 2859364 YP_041794.1 CDS tcaB NC_002952.2 2509792 2511000 R Previously sequenced as Staphylococcus aureus teicoplanin resistance associated membrane protein TcaB TR:Q9F4G1 (EMBL:AY008833) (402 aa) fasta scores: E(): 9.9e-140, 99.75% id in 402 aa. Similar to Bacillus subtilis bicyclomycin resistance protein YdgK TR:P96709 (EMBL:AB001488) (402 aa) fasta scores: E(): 8.8e-42, 38.17% id in 372 aa; teicoplanin resistance associated membrane protein complement(2509792..2511000) Staphylococcus aureus subsp. aureus MRSA252 2859520 YP_041795.1 CDS tcaA NC_002952.2 2511268 2512650 R No significant database matches. Previously sequenced as Staphylococcus aureus teicoplanin resistance associated hypothetical transmembrane protein TcaA TR:Q9F4G2 (EMBL:AY008833) (460 aa) fasta scores: E(): 5.2e-158, 98.69% id in 460 aa; teicoplanin resistance associated membrane protein complement(2511268..2512650) Staphylococcus aureus subsp. aureus MRSA252 2859519 YP_041796.1 CDS tcaR NC_002952.2 2512890 2513345 R Previously sequenced as Staphylococcus aureus teicoplanin resistance associated transcription regulator TcaR TR:Q9F4G3 (EMBL:AY008833) (151 aa) fasta scores: E(): 4.4e-47, 100% id in 151 aa. Similar to Bacillus subtilis YdgG TR:P96705 (EMBL:AB001488) (152 aa) fasta scores: E(): 0.00029, 25% id in 136 aa; MarR family regulatory protein complement(2512890..2513345) Staphylococcus aureus subsp. aureus MRSA252 2859521 YP_041797.1 CDS SAR2444 NC_002952.2 2513540 2514508 D Similar to Staphylococcus epidermidis membrane protein EpiH TR:O07859 (EMBL:U77778) (330 aa) fasta scores: E(): 5.5e-18, 30.12% id in 312 aa, and to Staphylococcus gallinarum membrane protein GdmH TR:O07474 (EMBL:U61158) (330 aa) fasta scores: E(): 1.3e-16, 30.89% id in 314 aa; hypothetical protein 2513540..2514508 Staphylococcus aureus subsp. aureus MRSA252 2859366 YP_041798.1 CDS SAR2445 NC_002952.2 2514738 2515403 R Similar to Lactococcus lactis ABC transporter ATP-binding protein YxeB TR:Q9CDG4 (EMBL:AE006454) (223 aa) fasta scores: E(): 2.5e-30, 46.6% id in 221 aa, and to Streptococcus pyogenes ABC transporter SPY0773 TR:Q9A0H6 (EMBL:AE006528) (222 aa) fasta scores: E(): 1.3e-26, 42% id in 219 aa; ABC transporter ATP-binding protein complement(2514738..2515403) Staphylococcus aureus subsp. aureus MRSA252 2859367 YP_041799.1 CDS SAR2446 NC_002952.2 2515403 2516458 R Similar to Deinococcus radiodurans hypothetical protein DRA0279 TR:Q9RYN1 (EMBL:AE001863) (353 aa) fasta scores: E(): 2.3e-22, 29.94% id in 354 aa, and to Lactococcus lactis ABC transporter permease YgfB TR:Q9CHR2 (EMBL:AE006299) (357 aa) fasta scores: E(): 6.3e-22, 29.36% id in 361 aa; permease complement(2515403..2516458) Staphylococcus aureus subsp. aureus MRSA252 2859368 YP_041800.1 CDS SAR2447 NC_002952.2 2516594 2517268 D Two-component regulatory system family, response regulator protein. Similar to Mycobacterium tuberculosis sensory transduction protein RegX3 SW:RGX3_MYCTU (Q11156) (227 aa) fasta scores: E(): 2.3e-28, 40.96% id in 227 aa, and to Mycobacterium bovis sensory transduction protein RegX3 SW:RGX3_MYCBO (O07130) (227 aa) fasta scores: E(): 4.9e-28, 40.52% id in 227 aa; response regulator protein 2516594..2517268 Staphylococcus aureus subsp. aureus MRSA252 2859369 YP_041801.1 CDS SAR2448 NC_002952.2 2517261 2518634 D Two-component regulatory system family, sensor kinase. Similar to Escherichia coli copper-responsive sensor kinase CusS SW:CUSS_ECOLI (P77485) (480 aa) fasta scores: E(): 7.4e-17, 27.44% id in 481 aa, and to Bacillus subtilis hypothetical protein YvqB TR:O32193 (EMBL:Z99120) (451 aa) fasta scores: E(): 3.2e-16, 25.32% id in 458 aa; sensor kinase 2517261..2518634 Staphylococcus aureus subsp. aureus MRSA252 2859370 YP_041802.1 CDS SAR2449 NC_002952.2 2518797 2519240 D Similar to Lactococcus lactis hypothetical protein YfcC TR:Q9CI31 (EMBL:AE006287) (152 aa) fasta scores: E(): 0.19, 24.32% id in 148 aa. C-terminus is similar to the C-terminal region of Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR SW:ALGR_PSEAE (P26275) (248 aa) fasta scores: E(): 0.16, 29.52% id in 105 aa; hypothetical protein 2518797..2519240 Staphylococcus aureus subsp. aureus MRSA252 2859371 YP_041803.1 CDS SAR2450 NC_002952.2 2519237 2519692 D Poor database matches. Weak similarity to Ochromonas danica hypothetical protein Orf154 TR:Q9G294 (EMBL:AF287134) (154 aa) fasta scores: E(): 0.38, 25.85% id in 147 aa; hypothetical protein 2519237..2519692 Staphylococcus aureus subsp. aureus MRSA252 2861010 YP_041804.1 CDS SAR2451 NC_002952.2 2519869 2520432 R Similar to Streptococcus pyogenes transcriptional regulator SPY2177 TR:Q99XJ5 (EMBL:AE006635) (177 aa) fasta scores: E(): 1.8e-11, 29.88% id in 174 aa, and to Bacillus halodurans transcriptional regulator BH0719 TR:Q9KEY0 (EMBL:AP001509) (188 aa) fasta scores: E(): 5.4e-09, 26.66% id in 180 aa; hypothetical protein complement(2519869..2520432) Staphylococcus aureus subsp. aureus MRSA252 2858975 YP_041805.1 CDS SAR2452 NC_002952.2 2520566 2521294 D Similar to Bacillus subtilis hypothetical protein YfiL TR:P94440 (EMBL:D78508) (311 aa) fasta scores: E(): 4.7e-24, 41.07% id in 224 aa. Similar to an internal region of Rhizobium sp nodulation ATP-binding protein I NodI SW:NODI_RHISN (P55476) (343 aa) fasta scores: E(): 1.1e-22, 38.59% id in 228 aa; ABC transporter ATP-binding protein 2520566..2521294 Staphylococcus aureus subsp. aureus MRSA252 2858976 YP_041806.1 CDS SAR2453 NC_002952.2 2521291 2522373 D Similar to Lactococcus lactis ABC transporter permease YcfC TR:Q9CIV1 (EMBL:AE006262) (380 aa) fasta scores: E(): 1.7e-30, 37.46% id in 379 aa, and to Archaeoglobus fulgidus ABC transporter ATP-binding protein AF1005 TR:O29257 (EMBL:AE001034) (366 aa) fasta scores: E(): 1.4e-17, 22.06% id in 358 aa; hypothetical protein 2521291..2522373 Staphylococcus aureus subsp. aureus MRSA252 2858977 YP_041807.2 CDS mqo1 NC_002952.2 2522500 2523978 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(2522500..2523978) Staphylococcus aureus subsp. aureus MRSA252 2861307 YP_041808.1 CDS lldP2 NC_002952.2 2524359 2525957 R Similar to Escherichia coli L-lactate permease LldP SW:LLDP_ECOLI (P33231) (551 aa) fasta scores: E(): 6.2e-49, 45.1% id in 541 aa, and to Bacillus subtilis L-lactate permease LctP TR:O31470 (EMBL:Z99105) (541 aa) fasta scores: E(): 1.4e-95, 50.73% id in 542 aa. Similar to SAR0113, 65.977% identity (66.352% ungapped) in 532 aa overlap; L-lactate permease 2 complement(2524359..2525957) Staphylococcus aureus subsp. aureus MRSA252 2859807 YP_041809.1 CDS SAR2456 NC_002952.2 2526274 2527947 D No significant database matches to the full length CDS. Internal region of the CDS is similar to an internal region of Staphylococcus epidermidis CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase TagF TR:Q9RPD1 (EMBL:AF162863) (721 aa) fasta scores: E(): 0.0032, 23.76% id in 324 aa, and to Lactococcus lactis teichoic acid biosynthesis protein B TagB TR:Q9CH14 (EMBL:AE006327) (371 aa) fasta scores: E(): 0.041, 22.22% id in 234 aa; hypothetical protein 2526274..2527947 Staphylococcus aureus subsp. aureus MRSA252 2858978 YP_041810.1 CDS SAR2457 NC_002952.2 2528101 2528730 R No significant database matches. Contains hydrophobic region, residues 18 to 107; hypothetical protein complement(2528101..2528730) Staphylococcus aureus subsp. aureus MRSA252 2858979 YP_041811.1 CDS SAR2458 NC_002952.2 2529046 2529561 R Similar to Bacillus subtilis protease synthase and sporulation negative regulatory protein Pai 1 PaiA SW:PAIA_BACSU (P21340) (171 aa) fasta scores: E(): 1.5e-21, 41.31% id in 167 aa, and to Lactobacillus delbrueckii hypothetical protein SW:YPIP_LACDL (P46543) (173 aa) fasta scores: E(): 5.7e-21, 38.95% id in 172 aa; acetyltransferase (GNAT) family protein complement(2529046..2529561) Staphylococcus aureus subsp. aureus MRSA252 2858980 YP_041812.1 CDS SAR2459 NC_002952.2 2529751 2530755 D Similar to Homo sapiens quinone oxidoreductase CRYZ SW:QOR_HUMAN (Q08257) (329 aa) fasta scores: E(): 1.6e-10, 28.23% id in 301 aa, and to Bacillus subtilis hypothetical protein YhfP TR:O07615 (EMBL:Y14084) (330 aa) fasta scores: E(): 4.2e-54, 47.41% id in 329 aa; zinc-binding dehydrogenase 2529751..2530755 Staphylococcus aureus subsp. aureus MRSA252 2858981 YP_041813.1 CDS SAR2460 NC_002952.2 2531321 2531722 R Similar to Lactococcus lactis hypothetical protein YfiL TR:Q9CHW9 (EMBL:AE006293) (154 aa) fasta scores: E(): 0.0048, 29.46% id in 112 aa, and to Streptococcus pyogenes ribosomal-protein-alanine acetyltransferase SPY1873 TR:Q99Y45 (EMBL:AE006612) (141 aa) fasta scores: E(): 0.02, 30.43% id in 115 aa; acetyltransferase (GNAT) family protein complement(2531321..2531722) Staphylococcus aureus subsp. aureus MRSA252 2858982 YP_041814.1 CDS SAR2461 NC_002952.2 2531758 2532792 R Similar to Bacillus subtilis hypothetical protein YcgT TR:O31475 (EMBL:Z99105) (336 aa) fasta scores: E(): 1.4e-37, 36.58% id in 328 aa, and to Bacillus halodurans thioredoxin reductase BH3408 TR:Q9K7F3 (EMBL:AP001518) (330 aa) fasta scores: E(): 1.4e-34, 34.45% id in 328 aa; pyridine nucleotide-disulfide oxidoreductase complement(2531758..2532792) Staphylococcus aureus subsp. aureus MRSA252 2858983 YP_041815.1 CDS SAR2462 NC_002952.2 2533019 2533450 R Poor database matches. Weak similarity to Rhizobium loti hypothetical protein MLR0532 TR:BAB48098 (EMBL:AP002995) (160 aa) fasta scores: E(): 1.1, 25.33% id in 150 aa; hypothetical protein complement(2533019..2533450) Staphylococcus aureus subsp. aureus MRSA252 2858984 YP_041816.1 CDS SAR2463 NC_002952.2 2533656 2534933 R No significant database matches to the full length CDS. N-terminus is weakly similar to the N-terminal region of Lactococcus lactis phage infection protein Pip SW:PIP_LACLA (P49022) (901 aa) fasta scores: E(): 0.00046, 27.12% id in 317 aa; hypothetical protein complement(2533656..2534933) Staphylococcus aureus subsp. aureus MRSA252 2858985 YP_041817.1 CDS SAR2464 NC_002952.2 2535094 2535717 D Similar to Lactococcus lactis transcriptional regulator YxcB TR:Q9CDI1 (EMBL:AE006453) (204 aa) fasta scores: E(): 3e-10, 26.86% id in 201 aa, and to Bacillus halodurans transcriptional regulator BH0719 TR:Q9KEY0 (EMBL:AP001509) (188 aa) fasta scores: E(): 1.5e-08, 29.67% id in 182 aa; TetR family regulatory protein 2535094..2535717 Staphylococcus aureus subsp. aureus MRSA252 2858986 YP_041818.1 CDS SAR2465 NC_002952.2 2535763 2536707 D Similar to Streptococcus pyogenes divalent cation transport protein SPY1827 TR:Q99Y83 (EMBL:AE006609) (314 aa) fasta scores: E(): 2.3e-31, 37.28% id in 295 aa, and to Lactococcus lactis cationic transporter ypbB TR:Q9CFJ3 (EMBL:AE006378) (301 aa) fasta scores: E(): 5e-32, 36.64% id in 292 aa; CorA-like Mg2+ transporter protein 2535763..2536707 Staphylococcus aureus subsp. aureus MRSA252 2858987 YP_041819.1 CDS scrA NC_002952.2 2536793 2538235 R Similar to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SW:PTSB_STAXY (P51184) (480 aa) fasta scores: E(): 5.9e-145, 82.21% id in 478 aa, and to Vibrio cholerae PTS system, sucrose-specific IIBC component VCA0653 TR:Q9KLT8 (EMBL:AE004395) (479 aa) fasta scores: E(): 8.3e-104, 59.16% id in 480 aa; PTS system, sucrose-specific IIBC component complement(2536793..2538235) Staphylococcus aureus subsp. aureus MRSA252 2859126 YP_041820.1 CDS SAR2467 NC_002952.2 2538418 2538801 D Poor database matches. Similar to Streptococcus pyogenes hypothetical protein SPY0771 TR:Q9A0H8 (EMBL:AE006528) (128 aa) fasta scores: E(): 1.8e-09, 35.59% id in 118 aa; hypothetical protein 2538418..2538801 Staphylococcus aureus subsp. aureus MRSA252 2858988 YP_041821.1 CDS SAR2468 NC_002952.2 2540289 2542394 D No significant database matches to the full length CDS. N-terminal region is weakly similar to Streptococcus mutans msm operon regulatory protein MsmR SW:MSMR_STRMU (Q00753) (278 aa) fasta scores: E(): 4.3e-06, 25.71% id in 245 aa; AraC family transcription regulator 2540289..2542394 Staphylococcus aureus subsp. aureus MRSA252 2858989 YP_041822.1 CDS SAR2469 NC_002952.2 2542465 2542887 D Similar to Bacillus subtilis general stress protein 26 YdaG SW:GS26_BACSU (P80238) (140 aa) fasta scores: E(): 3.1e-16, 38.57% id in 140 aa; hypothetical protein 2542465..2542887 Staphylococcus aureus subsp. aureus MRSA252 2858990 YP_041823.1 CDS SAR2470 NC_002952.2 2543165 2543521 D Poor database matches. Weakly similar to Fowlpox virus hypothetical protein FPV145 TR:Q9J585 (EMBL:AF198100) (103 aa) fasta scores: E(): 1.2, 27.27% id in 99 aa; hypothetical protein 2543165..2543521 Staphylococcus aureus subsp. aureus MRSA252 2858991 YP_041824.1 CDS SAR2471 NC_002952.2 2543734 2545380 R Similar to Staphylococcus aureus prophage phiPV83 transposase TR:Q9MBP7 (EMBL:AB044554) (548 aa) fasta scores: E(): 7.9e-199, 99.453% id in 548 aa, and to Bacillus halodurans cassette chromosome recombinase B1 BH0682 TR:Q9KF15 (EMBL:AP001509) (522 aa) fasta scores: E(): 3.2e-99, 52.115% id in 520 aa; transposase complement(2543734..2545380) Staphylococcus aureus subsp. aureus MRSA252 2858992 YP_041825.1 CDS gltT NC_002952.2 2545682 2546959 R Similar to Bacillus stearothermophilus proton/sodium-glutamate symport protein GltT SW:GLTT_BACST (P24943) (421 aa) fasta scores: E(): 1.7e-88, 55.23% id in 420 aa, and to Bacillus caldotenax proton/sodium-glutamate symport protein GltT SW:GLTT_BACCA (P24944) (421 aa) fasta scores: E(): 3.3e-88, 55.63% id in 417 aa; proton/sodium-glutamate symport protein complement(2545682..2546959) Staphylococcus aureus subsp. aureus MRSA252 2859932 YP_041826.1 CDS SAR2473 NC_002952.2 2547141 2547506 R Poor database matches. Similar to the N-terminal region of Bacillus halodurans D-alanyl-D-alanine carboxypeptidase BH1810 TR:Q9KBW4 (EMBL:AP001513) (290 aa) fasta scores: E(): 1.5, 28.88% id in 90 aa; hypothetical protein complement(2547141..2547506) Staphylococcus aureus subsp. aureus MRSA252 2858993 YP_041827.1 CDS SAR2474 NC_002952.2 2547903 2548349 D N-terminus is similar to the N-terminal regions of Lactococcus lactis transcriptional regulator RmaJ TR:Q9CHX7 (EMBL:AE006292) (143 aa) fasta scores: E(): 4e-18, 55.35% id in 112 aa, and Bacillus subtilis hypothetical protein YkmA TR:O34777 (EMBL:AJ002571) (147 aa) fasta scores: E(): 3.2e-13, 45.71% id in 105 aa; MarR family regulatory protein 2547903..2548349 Staphylococcus aureus subsp. aureus MRSA252 2858994 YP_041828.1 CDS SAR2475 NC_002952.2 2548573 2548995 D Similar to Clostridium acetobutylicum 18 kDa heat shock protein Hsp18 SW:HS18_CLOAB (Q03928) (151 aa) fasta scores: E(): 1e-06, 31.74% id in 126 aa, and to Streptococcus thermophilus second small heat shock protein Hsp2 TR:O52192 (EMBL:AF027167) (142 aa) fasta scores: E(): 5.4e-13, 40.84% id in 142 aa; small heat shock protein 2548573..2548995 Staphylococcus aureus subsp. aureus MRSA252 2858995 YP_041829.1 CDS narT NC_002952.2 2549103 2550272 R Similar to Staphylococcus carnosus nitrate transporter NarT TR:O33854 (EMBL:U40014) (388 aa) fasta scores: E(): 6.1e-106, 74.54% id in 381 aa, and to Bacillus subtilis nitrite extrusion protein NarK SW:NARK_BACSU (P46907) (395 aa) fasta scores: E(): 3.8e-72, 53.47% id in 374 aa; nitrite transport protein complement(2549103..2550272) Staphylococcus aureus subsp. aureus MRSA252 2859724 YP_041830.1 CDS SAR2477 NC_002952.2 2550781 2551695 D Poor database matches. Similar to Bacillus subtilis hypothetical protein YjfC TR:O34458 (EMBL:AF015825) (309 aa) fasta scores: E(): 1e-22, 30.2% id in 298 aa; hypothetical protein 2550781..2551695 Staphylococcus aureus subsp. aureus MRSA252 2859952 YP_041831.1 CDS SAR2480 NC_002952.2 2552668 2553321 R Two-component regulatory system family, response regulator protein. Similar to Vibrio vulnificus transcriptional regulator TR:Q9AEP5 (EMBL:AY029275) (212 aa) fasta scores: E(): 4.1e-26, 42.13% id in 216 aa. C-terminal region is similar to Staphylococcus carnosus response regulator-like protein TR:Q9ZB65 (EMBL:U40158) (185 aa) fasta scores: E(): 1.1e-58, 85.4% id in 185 aa; response regulator complement(2552668..2553321) Staphylococcus aureus subsp. aureus MRSA252 2859954 YP_041832.1 CDS SAR2481 NC_002952.2 2553344 2554378 R C-terminus is similar to the C-terminal regions of Bacillus subtilis sensor protein two-component sensor histidine kinase DegS SW:DEGS_BACSU (P13799) (385 aa) fasta scores: E(): 1.7e-16, 29.56% id in 274 aa, and Bacillus halodurans two-component sensor histidine kinase BH3629 TR:Q9K6U6 (EMBL:AP001519) (377 aa) fasta scores: E(): 1.1e-18, 30.11% id in 269 aa; histidine kinase complement(2553344..2554378) Staphylococcus aureus subsp. aureus MRSA252 2859955 YP_041833.1 CDS SAR2482 NC_002952.2 2554402 2554854 R Poor database matches. Similar to an internal region of Streptomyces coelicolor hypothetical protein 2SCG2.24c TR:Q9EX29 (EMBL:AL445963) (634 aa) fasta scores: E(): 1.1, 23.3% id in 133 aa; hypothetical protein complement(2554402..2554854) Staphylococcus aureus subsp. aureus MRSA252 2859956 YP_041834.1 CDS narI NC_002952.2 2554874 2555551 R Similar to Bacillus subtilis nitrate reductase gamma chain NarI SW:NARI_BACSU (P42177) (223 aa) fasta scores: E(): 1.3e-41, 49.09% id in 222 aa, and to Staphylococcus carnosus nitrate reductase gamma chain NarI TR:Q9ZIF5 (EMBL:AF029224) (227 aa) fasta scores: E(): 1.1e-64, 70.53% id in 224 aa; nitrate reductase gamma chain complement(2554874..2555551) Staphylococcus aureus subsp. aureus MRSA252 2861335 YP_041835.1 CDS narJ NC_002952.2 2555544 2556119 R Similar to Escherichia coli respiratory nitrate reductase 2 delta chain NarW SW:NARW_ECOLI (P19317) (231 aa) fasta scores: E(): 0.00098, 24.71% id in 174 aa, and to Staphylococcus carnosus nitrate reductase delta chain NarJ TR:Q9ZIF6 (EMBL:AF029224) (191 aa) fasta scores: E(): 7.8e-52, 68.06% id in 191 aa; respiratory nitrate reductase delta chain complement(2555544..2556119) Staphylococcus aureus subsp. aureus MRSA252 2859722 YP_041836.1 CDS narH NC_002952.2 2556112 2557671 R Similar to Bacillus subtilis nitrate reductase beta chain NarH SW:NARH_BACSU (P42176) (487 aa) fasta scores: E(): 5.3e-142, 66.94% id in 484 aa, and to Staphylococcus carnosus nitrate reductase beta chain NarH TR:Q9ZIF7 (EMBL:AF029224) (525 aa) fasta scores: E(): 1.5e-187, 83.61% id in 525 aa; nitrate reductase subunit beta complement(2556112..2557671) Staphylococcus aureus subsp. aureus MRSA252 2861334 YP_041837.1 CDS narG NC_002952.2 2557661 2561350 R Similar to Bacillus subtilis nitrate reductase alpha chain NarG SW:NARG_BACSU (P42175) (1228 aa) fasta scores: E(): 0, 59.21% id in 1226 aa, and to Staphylococcus carnosus nitrate reductase alpha chainNarG TR:Q9ZIF8 (EMBL:AF029224) (1224 aa) fasta scores: E(): 0, 80.55% id in 1229 aa; nitrate reductase subunit alpha complement(2557661..2561350) Staphylococcus aureus subsp. aureus MRSA252 2861333 YP_041838.1 CDS SAR2487 NC_002952.2 2561657 2562634 R N-terminal region is similar to Bacillus megaterium uroporphyrin-III C-methyltransferase CobA SW:SUMT_BACME (P29928) (238 aa) fasta scores: E(): 2.8e-31, 43.69% id in 238 aa. Full length CDS is similar to Staphylococcus carnosus hypothetical protein SirB TR:Q9X2N1 (EMBL:AF029224) (317 aa) fasta scores: E(): 2.6e-57, 52.05% id in 317 aa; tetrapyrrole (corrin/porphyrin) methylase complement(2561657..2562634) Staphylococcus aureus subsp. aureus MRSA252 2859957 YP_041839.1 CDS nasE NC_002952.2 2562625 2562939 R Similar to Bacillus subtilis assimilatory nitrite reductase [NAD(P)H] small subunit NasE SW:NASE_BACSU (P42436) (106 aa) fasta scores: E(): 1.3e-17, 50.51% id in 97 aa, and to Staphylococcus carnosus assimilatory nitrite reductase small subunit NirD TR:Q9X2N0 (EMBL:AF029224) (104 aa) fasta scores: E(): 1.3e-29, 69.23% id in 104 aa; assimilatory nitrite reductase small subunit complement(2562625..2562939) Staphylococcus aureus subsp. aureus MRSA252 2859163 YP_041840.1 CDS nasD NC_002952.2 2562943 2565348 R Similar to Bacillus subtilis nitrite reductase [NAD(P)H] large subunit NasD SW:NASD_BACSU (P42435) (805 aa) fasta scores: E(): 2.6e-168, 53.18% id in 801 aa, and to Staphylococcus carnosus nitrite reductase [NAD(P)H] large subunit NirB TR:Q9X2M9 (EMBL:AF029224) (801 aa) fasta scores: E(): 0, 77.77% id in 801 aa; nitrite reductase large subunit complement(2562943..2565348) Staphylococcus aureus subsp. aureus MRSA252 2859162 YP_041841.1 CDS SAR2490 NC_002952.2 2565394 2566146 R Similar to Staphylococcus carnosus hypothetical protein NirR TR:Q9X2M7 (EMBL:AF029224) (240 aa) fasta scores: E(): 3e-26, 35.16% id in 236 aa, and to Bacillus subtilis hypothetical protein YlnE TR:O34632 (EMBL:AJ000974) (261 aa) fasta scores: E(): 4.9e-09, 22.67% id in 247 aa; hypothetical protein complement(2565394..2566146) Staphylococcus aureus subsp. aureus MRSA252 2859958 YP_041842.1 CDS SAR2491 NC_002952.2 2566374 2566910 R Similar to Bacillus subtilis hypothetical protein YtmI TR:O34350 (EMBL:AF008220) (178 aa) fasta scores: E(): 7.9e-40, 57.95% id in 176 aa, and to Bacillus subtilis hypothetical protein YxeL SW:YXEL_BACSU (P54951) (165 aa) fasta scores: E(): 1.7e-24, 45.86% id in 157 aa; acetyltransferase (GNAT) family protein complement(2566374..2566910) Staphylococcus aureus subsp. aureus MRSA252 2859959 YP_041843.1 CDS SAR2493 NC_002952.2 2567378 2568202 R Similar to Escherichia coli potential nitrite transporter NirC SW:NIRC_ECOLI (P11097) (268 aa) fasta scores: E(): 6.3e-12, 30.57% id in 242 aa, and to Staphylococcus carnosus potential nitrite transporter NirC TR:Q9X2M6 (EMBL:AF029224) (276 aa) fasta scores: E(): 5.3e-63, 63.63% id in 275 aa; nitrite transporter complement(2567378..2568202) Staphylococcus aureus subsp. aureus MRSA252 2859960 YP_041844.1 CDS SAR2494 NC_002952.2 2568405 2568587 R hypothetical protein complement(2568405..2568587) Staphylococcus aureus subsp. aureus MRSA252 2859961 YP_041845.1 CDS SAR2495 NC_002952.2 2568673 2569140 R Similar to Bacillus halodurans hypothetical protein BH0695 TR:Q9KF04 (EMBL:AP001509) (169 aa) fasta scores: E(): 7e-09, 28.22% id in 163 aa, and to Caulobacter crescentus hypothetical protein CC3077 TR:Q9A3X4 (EMBL:AE005971) (158 aa) fasta scores: E(): 1.9e-05, 26.49% id in 151 aa; hypothetical protein complement(2568673..2569140) Staphylococcus aureus subsp. aureus MRSA252 2859962 YP_041846.1 CDS SAR2496 NC_002952.2 2569326 2570873 R Similar to Streptococcus pyogenes zinc-binding protein AdcA precursor SPY0714 TR:Q9A0L9 (EMBL:AE006523) (515 aa) fasta scores: E(): 1.9e-53, 37.02% id in 524 aa. N-terminal region is similar to Bacillus subtilis hypothetical protein YcdH TR:O34966 (EMBL:AB000617) (319 aa) fasta scores: E(): 1.7e-15, 33.84% id in 325 aa; solute binding lipoprotein complement(2569326..2570873) Staphylococcus aureus subsp. aureus MRSA252 2859963 YP_041847.1 CDS SAR2497 NC_002952.2 2571166 2571432 R Similar to Escherichia coli hypothetical protein YoeB SW:YOEB_ECOLI (P56605) (84 aa) fasta scores: E(): 6.8e-14, 52.94% id in 85 aa, and to Streptomyces coelicolor hypothetical protein SCBAC17D6.03 TR:Q9Z4V8 (EMBL:Y17736) (84 aa) fasta scores: E(): 1.1e-11, 47.05% id in 85 aa; hypothetical protein complement(2571166..2571432) Staphylococcus aureus subsp. aureus MRSA252 2859964 YP_041848.1 CDS SAR2498 NC_002952.2 2571432 2571683 R Similar to Escherichia coli hypothetical protein YefM SW:YEFM_ECOLI (P46147) (83 aa) fasta scores: E(): 3.7e-07, 44.15% id in 77 aa, and to Streptomyces coelicolor hypothetical protein SCBAC17D6.02 SW:YU1E_STRCO (Q9Z4V7) (87 aa) fasta scores: E(): 1.4e-05, 42.66% id in 75 aa; hypothetical protein complement(2571432..2571683) Staphylococcus aureus subsp. aureus MRSA252 2859965 YP_041849.1 CDS SAR2499 NC_002952.2 2571954 2572553 R Similar to Caulobacter crescentus hypothetical protein CC0375 TR:Q9AB57 (EMBL:AE005710) (204 aa) fasta scores: E(): 0.00026, 28.27% id in 191 aa. C-terminus is similar to the C-terminal region of Bacillus subtilis hypothetical protein YvgV TR:O32218 (EMBL:Z99121) (222 aa) fasta scores: E(): 7e-14, 36.41% id in 173 aa; lipoprotein complement(2571954..2572553) Staphylococcus aureus subsp. aureus MRSA252 2859966 YP_041850.1 CDS SAR2500 NC_002952.2 2572572 2572934 R Similar to Bacillus subtilis hypothetical protein YddJ TR:P96647 (EMBL:AB001488) (126 aa) fasta scores: E(): 0.12, 29.34% id in 92 aa; lipoprotein complement(2572572..2572934) Staphylococcus aureus subsp. aureus MRSA252 2859967 YP_041851.1 CDS fmhA NC_002952.2 2573189 2574439 D Similar to Staphylococcus aureus factor essential for expression of methicillin resistance FemA SW:FEMA_STAAU (P14304) (433 aa) fasta scores: E(): 7.3e-63, 43.82% id in 413 aa. Previously sequenced as Staphylococcus aureus FemA-like protein FmhA TR:Q9X4D6 (EMBL:AF106849) (416 aa) fasta scores: E(): 1.1e-152, 98.31% id in 416 aa. Similar to SAR1224, 60.934% identity (60.934% ungapped) in 407 aa overlap; FemAB family protein 2573189..2574439 Staphylococcus aureus subsp. aureus MRSA252 2860668 YP_041852.1 CDS SAR2502 NC_002952.2 2574532 2575263 R Similar to Bacillus subtilis hypothetical protein YckI TR:Q9F4F9 (EMBL:AY009114) (247 aa) fasta scores: E(): 1.8e-44, 58.43% id in 243 aa, and to Bacillus halodurans amino acid ABC transporter (ATP-binding protein) BH0172 TR:Q9KGD1 (EMBL:AP001507) (247 aa) fasta scores: E(): 2.7e-44, 58.6% id in 244 aa. Similar to SAR1948, 54.622% identity (55.319% ungapped) in 238 aa overlap; ABC transporter ATP-binding protein complement(2574532..2575263) Staphylococcus aureus subsp. aureus MRSA252 2859968 YP_041853.1 CDS SAR2503 NC_002952.2 2575260 2575979 R Similar to Lactobacillus fermentum integral membrane protein homologue TR:O06528 (EMBL:U97348) (233 aa) fasta scores: E(): 2.3e-31, 45.74% id in 223 aa, and to Lactobacillus reuteri transmembrane protein TR:Q9FCU7 (EMBL:AJ293860) (233 aa) fasta scores: E(): 3.1e-31, 46.18% id in 223 aa; transport system membrane protein complement(2575260..2575979) Staphylococcus aureus subsp. aureus MRSA252 2859969 YP_041854.1 CDS SAR2504 NC_002952.2 2575960 2576739 R Similar to Escherichia coli cystine-binding periplasmic protein precursor FliY SW:FLIY_ECOLI (P39174) (266 aa) fasta scores: E(): 1e-22, 37.22% id in 231 aa, and to Haemophilus influenzae probable amino-acid ABC transporter binding protein HI1080 SW:YA80_HAEIN (P45024) (257 aa) fasta scores: E(): 6.6e-39, 45.73% id in 258 aa; extracellular solute-binding lipoprotein complement(2575960..2576739) Staphylococcus aureus subsp. aureus MRSA252 2859970 YP_041855.1 CDS SAR2505 NC_002952.2 2576860 2578299 R Similar to Bacillus subtilis hypothetical protein YcnB TR:P94422 (EMBL:D50453) (472 aa) fasta scores: E(): 2e-68, 41.7% id in 470 aa, and to Bacillus subtilis lincomycin-resistance protein LmrB TR:O35018 (EMBL:AB000617) (479 aa) fasta scores: E(): 1.2e-62, 37.44% id in 478 aa; transporter complement(2576860..2578299) Staphylococcus aureus subsp. aureus MRSA252 2859971 YP_041856.1 CDS gpmA NC_002952.2 2578730 2579416 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(2578730..2579416) Staphylococcus aureus subsp. aureus MRSA252 2859972 YP_041857.1 CDS SAR2507 NC_002952.2 2579743 2580609 R Similar to Bacillus subtilis hypothetical protein YdbO TR:P96610 (EMBL:AB001488) (290 aa) fasta scores: E(): 2.8e-42, 42.9% id in 289 aa, and to the N-terminal region of Streptococcus pyogenes cation efflux system protein SPY1272 TR:Q99ZD9 (EMBL:AE006566) (411 aa) fasta scores: E(): 9.5e-40, 40.92% id in 281 aa; cation efflux family protein complement(2579743..2580609) Staphylococcus aureus subsp. aureus MRSA252 2859973 YP_041858.1 CDS sbi NC_002952.2 2581308 2582621 D Similar to Staphylococcus aureus IgG-binding protein Sbi TR:O52187 (EMBL:AF027155) (436 aa) fasta scores: E(): 2.2e-121, 93.13% id in 437 aa. N-terminus is similar to the N-terminal region of Staphylococcus aureus immunoglobulin G binding protein A precursor Spa SW:SPA1_STAAU (P02976) (524 aa) fasta scores: E(): 1.4e-07, 28.77% id in 351 aa; IgG-binding protein 2581308..2582621 Staphylococcus aureus subsp. aureus MRSA252 2859124 YP_041859.1 CDS hlgA NC_002952.2 2583157 2584086 D Highly similar to Staphylococcus aureus gamma-hemolysin component A precursor HlgA SW:HLGA_STAAU (P31714) (309 aa) fasta scores: E(): 3.1e-115, 99.35% id in 309 aa. Similar to Staphylococcus aureus leukocidin S subunit precursor LukS SW:LUKS_STAAU (P31716) (315 aa) fasta scores: E(): 1.4e-76, 68.26% id in 312 aa. Similar to SAR2510, 68.910% identity (70.724% ungapped) in 312 aa overlap; gamma-hemolysin component A precursor 2583157..2584086 Staphylococcus aureus subsp. aureus MRSA252 2859641 YP_041860.1 CDS hlgC NC_002952.2 2584636 2585583 D Highly similar to Staphylococcus aureus leukocidin S subunit precursor LukS SW:LUKS_STAAU (P31716) (315 aa) fasta scores: E(): 8.6e-118, 97.77% id in 315 aa. Similar to Staphylococcus aureus gamma-hemolysin component A precursor HlgA SW:HLGA_STAAU (P31714) (309 aa) fasta scores: E(): 1.3e-77, 68.59% id in 312 aa. Similar to SAR2509, 68.910% identity (70.724% ungapped) in 312 aa overlap; gamma-hemolysin component C precursor 2584636..2585583 Staphylococcus aureus subsp. aureus MRSA252 2859643 YP_041861.1 CDS hlgB NC_002952.2 2585585 2586562 D Identical to Staphylococcus aureus HlgB-like precursor Luk F-R TR:Q57227 (EMBL:X81586) (325 aa) fasta scores: E(): 1.4e-125, 100% id in 325 aa. Similar to Staphylococcus aureus leukocidin F subunit precursor LukF SW:LUKF_STAAU (P31715) (323 aa) fasta scores: E(): 1.5e-119, 96.3% id in 325 aa; gamma-hemolysin component C precursor 2585585..2586562 Staphylococcus aureus subsp. aureus MRSA252 2859642 YP_041862.1 CDS SAR2512 NC_002952.2 2586614 2587081 R Similar to Bacillus sphaericus hypothetical protein BioX SW:BIOX_BACSH (P22821) (166 aa) fasta scores: E(): 2.6e-15, 40% id in 145 aa, and to Streptococcus pyogenes hypothetical protein SPY0373 TR:Q9A1A8 (EMBL:AE006500) (187 aa) fasta scores: E(): 1.2, 27.95% id in 161 aa; hypothetical protein complement(2586614..2587081) Staphylococcus aureus subsp. aureus MRSA252 2859974 YP_041863.1 CDS SAR2513 NC_002952.2 2587092 2587784 R catalyzes the formation of pimeloyl-CoA from pimelate and coenzyme A; 6-carboxyhexanoate--CoA ligase complement(2587092..2587784) Staphylococcus aureus subsp. aureus MRSA252 2859975 YP_041864.1 CDS SAR2514 NC_002952.2 2587795 2588910 R Similar to Bacillus subtilis 8-amino-7-oxononanoate synthase BioF SW:BIOF_BACSU (P53556) (389 aa) fasta scores: E(): 2.6e-29, 29.63% id in 378 aa, and to Bacillus sphaericus 8-amino-7-oxononanoate synthase BioF SW:BIOF_BACSH (P22806) (389 aa) fasta scores: E(): 2.5e-27, 29.45% id in 370 aa; 8-amino-7-oxononanoate synthase complement(2587795..2588910) Staphylococcus aureus subsp. aureus MRSA252 2859976 YP_041865.1 CDS bioB NC_002952.2 2588888 2589895 R catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase complement(2588888..2589895) Staphylococcus aureus subsp. aureus MRSA252 2858971 YP_041866.1 CDS bioA NC_002952.2 2589897 2591255 R Similar to Bacillus subtilis adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA SW:BIOA_BACSU (P53555) (448 aa) fasta scores: E(): 3.6e-83, 48.43% id in 446 aa, and to Bacillus sphaericus adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA SW:BIOA_BACSH (P22805) (455 aa) fasta scores: E(): 2.2e-63, 36.44% id in 450 aa; adenosylmethionine-8-amino-7-oxononanoate aminotransferase complement(2589897..2591255) Staphylococcus aureus subsp. aureus MRSA252 2858970 YP_041867.1 CDS SAR2517 NC_002952.2 2591233 2591919 R Similar to Bacillus sphaericus dethiobiotin synthetase BioD SW:BIOD_BACSH (P22818) (234 aa) fasta scores: E(): 7.1e-11, 29.3% id in 215 aa, and to Bacillus subtilis dethiobiotin synthetase BioD SW:BIOD_BACSU (P53558) (231 aa) fasta scores: E(): 4.5e-07, 28.42% id in 197 aa; dethiobiotin synthetase complement(2591233..2591919) Staphylococcus aureus subsp. aureus MRSA252 2859977 YP_041868.1 CDS SAR2518 NC_002952.2 2592372 2594105 R Similar to Proteus mirabilis NrpA hypothetical protein TR:Q9ZB58 (EMBL:U46488) (588 aa) fasta scores: E(): 1.2e-51, 33.79% id in 577 aa, and to Thermotoga maritima hypothetical ABC transporter ATP-binding protein TM0288 SW:Y288_THEMA (Q9WYC4) (598 aa) fasta scores: E(): 5.7e-45, 31.87% id in 571 aa; ABC transporter ATP-binding protein complement(2592372..2594105) Staphylococcus aureus subsp. aureus MRSA252 2859978 YP_041869.1 CDS SAR2519 NC_002952.2 2594130 2595914 R Similar to Zymomonas mobilis lipoprotein inner membrane ABC-transporter TR:Q9REN6 (EMBL:AF213822) (599 aa) fasta scores: E(): 1.2e-53, 33.91% id in 575 aa, and to Streptomyces coelicolor ABC transporter ATP-binding protein SC4C2.24 TR:Q9EWN8 (EMBL:AL450432) (608 aa) fasta scores: E(): 2.6e-52, 34.04% id in 564 aa; ABC transporter ATP-binding protein complement(2594130..2595914) Staphylococcus aureus subsp. aureus MRSA252 2859979 YP_041870.1 CDS SAR2519a NC_002952.2 2596407 2596514 R Doubtful CDS; hypothetical protein complement(2596407..2596514) Staphylococcus aureus subsp. aureus MRSA252 2859980 YP_041871.1 CDS SAR2520 NC_002952.2 2596545 2596799 D Doubtful CDS. No significant database matches; hypothetical protein 2596545..2596799 Staphylococcus aureus subsp. aureus MRSA252 2859981 YP_041872.1 CDS SAR2521 NC_002952.2 2596782 2597168 R Similar to Listeria monocytogenes cell wall teichoic acid glycosylation protein GtcA SW:GTCA_LISMO (Q9ZH29) (123 aa) fasta scores: E(): 0.00074, 28.92% id in 121 aa, and to Streptomyces coelicolor sugar translocase 2SCK8.02 TR:Q9AK50 (EMBL:AL589164) (148 aa) fasta scores: E(): 1.5e-14, 41.37% id in 116 aa; hypothetical protein complement(2596782..2597168) Staphylococcus aureus subsp. aureus MRSA252 2859982 YP_041873.1 CDS SAR2522 NC_002952.2 2597436 2598578 D Similar to Escherichia coli glycerate kinase 1 GlxK SW:GRK1_ECOLI (P77364) (381 aa) fasta scores: E(): 4.9e-61, 46.93% id in 375 aa, and to Bacillus halodurans glycerate kinase BH0555 SW:GRK_BACHD (Q9Z9P2) (380 aa) fasta scores: E(): 1.1e-68, 50.26% id in 374 aa; glycerate kinase 2597436..2598578 Staphylococcus aureus subsp. aureus MRSA252 2859983 YP_041874.1 CDS SAR2523 NC_002952.2 2598638 2599297 D hypothetical protein 2598638..2599297 Staphylococcus aureus subsp. aureus MRSA252 2859984 YP_041875.1 CDS SAR2524 NC_002952.2 2599479 2600690 D Similar to Staphylococcus aureus teicoplanin resistance associated membrane protein TcaB TR:Q9F4G1 (EMBL:AY008833) (402 aa) fasta scores: E(): 1.7e-62, 47.46% id in 394 aa, and to Escherichia coli bicyclomycin resistance protein Bcr SW:BCR_ECOLI (P28246) (396 aa) fasta scores: E(): 7.1e-30, 28.98% id in 376 aa; transporter protein 2599479..2600690 Staphylococcus aureus subsp. aureus MRSA252 2859985 YP_041876.1 CDS SAR2525 NC_002952.2 2600813 2601286 R Similar to the C-terminal regions of Lactococcus lactis positive transcriptional activator TR:O87252 (EMBL:AE001272) (265 aa) fasta scores: E(): 1.7e-12, 33.12% id in 157 aa, and Bacillus subtilis probable AraC family transcriptional regulator YdeE TR:P96662 (EMBL:AB001488) (290 aa) fasta scores: E(): 0.35, 21.34% id in 164 aa. Possible gene remnant; hypothetical protein complement(2600813..2601286) Staphylococcus aureus subsp. aureus MRSA252 2859986 YP_041877.1 CDS SAR2526 NC_002952.2 2601399 2602055 D Similar to the C-terminal regions of Bacillus subtilis hypothetical protein YvpB TR:O34735 (EMBL:AF017113) (250 aa) fasta scores: E(): 0.0011, 26.59% id in 173 aa, and Lactococcus lactis hypothetical protein YxaF TR:Q9CDJ5 (EMBL:AE006451) (225 aa) fasta scores: E(): 0.053, 25.3% id in 166 aa. Possible gene remnant; hypothetical protein 2601399..2602055 Staphylococcus aureus subsp. aureus MRSA252 2859987 YP_041878.1 CDS SAR2527 NC_002952.2 2602118 2602924 R Similar to Lactococcus lactis hypothetical protein YjjH TR:Q9CGX2 (EMBL:AE006331) (243 aa) fasta scores: E(): 9.5e-06, 26.27% id in 255 aa, and to Bacillus subtilis hypothetical protein YotB TR:O34642 (EMBL:Z99114) (275 aa) fasta scores: E(): 0.0094, 23.55% id in 276 aa; hypothetical protein complement(2602118..2602924) Staphylococcus aureus subsp. aureus MRSA252 2859988 YP_041879.1 CDS SAR2528 NC_002952.2 2603209 2604618 D Similar to Escherichia coli D-serine/D-alanine/glycine transporter CycA SW:CYCA_ECOLI (P39312) (470 aa) fasta scores: E(): 8.3e-88, 50.44% id in 454 aa, and to Bacillus subtilis hypothetical transport protein YdgF SW:YDGF_BACSU (P96704) (458 aa) fasta scores: E(): 5.1e-87, 51.58% id in 442 aa. Similar to SAR1775, 65.410% identity (65.556% ungapped) in 451 aa overlap; amino acid permease 2603209..2604618 Staphylococcus aureus subsp. aureus MRSA252 2859989 YP_041880.1 CDS SAR2529 NC_002952.2 2604756 2606834 D Similar to Bacillus subtilis hypothetical protein YvgP TR:O32212 (EMBL:Z99121) (670 aa) fasta scores: E(): 3.4e-48, 31.06% id in 692 aa, and to Lactococcus lactis Na+/H+ antiporter YdiF TR:Q9CIH7 (EMBL:AE006275) (680 aa) fasta scores: E(): 5.5e-36, 27.32% id in 688 aa; sodium/hydrogen exchanger family protein 2604756..2606834 Staphylococcus aureus subsp. aureus MRSA252 2859990 YP_041881.1 CDS SAR2530 NC_002952.2 2606974 2608803 R Similar to Bacillus subtilis hypothetical protein YdaO TR:P96589 (EMBL:AB001488) (607 aa) fasta scores: E(): 3.9e-126, 56.55% id in 610 aa, and to Mycobacterium tuberculosis hypothetical protein MTCY05A6.11c TR:O07192 (EMBL:Z96072) (657 aa) fasta scores: E(): 5.7e-32, 35.33% id in 634 aa; hypothetical protein complement(2606974..2608803) Staphylococcus aureus subsp. aureus MRSA252 2859991 YP_041882.1 CDS SAR2531 NC_002952.2 2609035 2610534 D Highly similar to Staphylococcus aureus FmtA-like protein Flp TR:Q9KJ74 (EMBL:AF210139) (498 aa) fasta scores: E(): 1.3e-171, 94.76% id in 497 aa. Similar to Bacillus halodurans hypothetical protein BH0715 TR:Q9KEY4 (EMBL:AP001509) (478 aa) fasta scores: E(): 2.2e-21, 26.84% id in 462 aa; hypothetical protein 2609035..2610534 Staphylococcus aureus subsp. aureus MRSA252 2859992 YP_041883.1 CDS SAR2532 NC_002952.2 2610641 2611492 R Similar to Vibrio cholerae hypothetical protein VC1697 TR:Q9KRE5 (EMBL:AE004247) (276 aa) fasta scores: E(): 0.001, 22.82% id in 276 aa, and to Halobacterium sp hypothetical protein VNG0267H TR:Q9HSE7 (EMBL:AE004989) (297 aa) fasta scores: E(): 2e-06, 25.09% id in 255 aa; hypothetical protein complement(2610641..2611492) Staphylococcus aureus subsp. aureus MRSA252 2859993 YP_041884.1 CDS SAR2533 NC_002952.2 2611814 2612749 R ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase complement(2611814..2612749) Staphylococcus aureus subsp. aureus MRSA252 2859994 YP_041885.1 CDS SAR2534 NC_002952.2 2612975 2614375 R Similar to Pseudomonas aeruginosa probable MFS transporter PA1316 TR:Q9I428 (EMBL:AE004561) (513 aa) fasta scores: E(): 6e-26, 31.45% id in 426 aa, and to Rhizobium loti transmembrane efflux protein MLL5686 TR:BAB52087 (EMBL:AP003007) (502 aa) fasta scores: E(): 1.5e-24, 26.1% id in 429 aa. Similar to SAR0109, 59.913% identity (60.706% ungapped) in 459 aa overlap, and to SAR1448, 57.204% identity (58.079% ungapped) in 465 aa overlap; transport protein complement(2612975..2614375) Staphylococcus aureus subsp. aureus MRSA252 2858889 YP_041886.1 CDS opuCD NC_002952.2 2614669 2615364 R Similar to Bacillus subtilis glycine betaine/carnitine/choline ABC transporter permease OpuCD SW:OPCD_BACSU (O34742) (229 aa) fasta scores: E(): 1.8e-46, 59.25% id in 216 aa, and to Listeria monocytogenes membrane permease OpuCD TR:Q9KHT6 (EMBL:AF249729) (223 aa) fasta scores: E(): 5.1e-46, 61.11% id in 216 aa; glycine betaine/carnitine/choline ABC transporter permease complement(2614669..2615364) Staphylococcus aureus subsp. aureus MRSA252 2860978 YP_041887.1 CDS opuCC NC_002952.2 2615364 2616305 R Similar to Bacillus subtilis glycine betaine/carnitine/choline-binding protein precursor OpuCC SW:OPCC_BACSU (O32243) (303 aa) fasta scores: E(): 3e-65, 56.2% id in 306 aa, and to Listeria monocytogenes substrate binding protein OpuCC TR:Q9KHT7 (EMBL:AF249729) (308 aa) fasta scores: E(): 1e-70, 60.51% id in 309 aa; glycine betaine/carnitine/choline-binding lipoprotein precursor complement(2615364..2616305) Staphylococcus aureus subsp. aureus MRSA252 2859187 YP_041888.1 CDS opuCB NC_002952.2 2616322 2616957 R Similar to Bacillus subtilis glycine betaine/carnitine/choline ABC transporter permease OpuCB SW:OPCB_BACSU (O34878) (217 aa) fasta scores: E(): 2.6e-39, 51.92% id in 208 aa, and to Listeria monocytogenes membrane permease OpuCB TR:Q9KHT8 (EMBL:AF249729) (218 aa) fasta scores: E(): 1.1e-38, 53.36% id in 208 aa; glycine betaine/carnitine/choline ABC transporter permease complement(2616322..2616957) Staphylococcus aureus subsp. aureus MRSA252 2859186 YP_041889.1 CDS opuCA NC_002952.2 2616954 2618180 R Similar to Bacillus subtilis glycine betaine/carnitine/choline transport ATP-binding protein OpuCA SW:OPCA_BACSU (O34992) (380 aa) fasta scores: E(): 5.9e-76, 59.2% id in 375 aa, and to Listeria monocytogenes ATPase OpuCA TR:Q9KHT9 (EMBL:AF249729) (397 aa) fasta scores: E(): 4.5e-81, 60.56% id in 393 aa; glycine betaine/carnitine/choline transport ATP-binding protein complement(2616954..2618180) Staphylococcus aureus subsp. aureus MRSA252 2859185 YP_041890.1 CDS SAR2539 NC_002952.2 2618850 2619449 R Similar to Bacillus halodurans hypothetical protein BH2088 TR:Q9Z9R5 (EMBL:AB013367) (197 aa) fasta scores: E(): 4.4e-37, 55.05% id in 198 aa, and to Bacillus subtilis hypothetical protein YdeI TR:P96666 (EMBL:AB001488) (197 aa) fasta scores: E(): 1.2e-35, 54.54% id in 198 aa; hypothetical protein complement(2618850..2619449) Staphylococcus aureus subsp. aureus MRSA252 2859189 YP_041891.1 CDS SAR2540 NC_002952.2 2619630 2621267 D Similar to Bacillus subtilis YbeC TR:Q45577 (EMBL:Z99105) (539 aa) fasta scores: E(): 5.7e-102, 48.23% id in 539 aa, and to Thermoplasma acidophilum L-asparagine permease related protein TA0427 TR:Q9HL13 (EMBL:AL445064) (557 aa) fasta scores: E(): 2.6e-56, 32.38% id in 525 aa; amino acid permease 2619630..2621267 Staphylococcus aureus subsp. aureus MRSA252 2859190 YP_041892.1 CDS SAR2541 NC_002952.2 2621574 2622926 D Similar to Bacillus subtilis para-nitrobenzyl esterase PnbA SW:PNBA_BACSU (P37967) (489 aa) fasta scores: E(): 6.2e-31, 32.54% id in 464 aa, and to Bacillus sp BP-7 type B carboxylesterase EstA1 TR:Q9L378 (EMBL:AJ278066) (486 aa) fasta scores: E(): 1.1e-31, 31.6% id in 462 aa; carboxylesterase 2621574..2622926 Staphylococcus aureus subsp. aureus MRSA252 2859191 YP_041893.1 CDS SAR2542 NC_002952.2 2622988 2624175 R Similar to Pseudomonas aeruginosa probable MFS transporter PA3303 TR:Q9HYU1 (EMBL:AE004752) (391 aa) fasta scores: E(): 1.8e-29, 33.05% id in 363 aa, and to Bacillus subtilis hypothetical protein YdhL TR:O05504 (EMBL:D88802) (425 aa) fasta scores: E(): 1e-28, 30.76% id in 377 aa; transport protein complement(2622988..2624175) Staphylococcus aureus subsp. aureus MRSA252 2859192 YP_041894.1 CDS SAR2543 NC_002952.2 2624569 2625345 R Similar to Escherichia coli hypothetical protein YbbM SW:YBBM_ECOLI (P77307) (259 aa) fasta scores: E(): 5.2e-38, 45.96% id in 248 aa, and to Bacillus subtilis hypothetical protein YjkA TR:O34684 (EMBL:AF015825) (250 aa) fasta scores: E(): 6.3e-21, 32.12% id in 249 aa; hypothetical protein complement(2624569..2625345) Staphylococcus aureus subsp. aureus MRSA252 2859193 YP_041895.1 CDS SAR2544 NC_002952.2 2625338 2626000 R Similar to Escherichia coli hypothetical ABC transporter ATP-binding protein YbbL SW:YBBL_ECOLI (P77279) (225 aa) fasta scores: E(): 3.5e-23, 42.92% id in 205 aa, and to Methanococcus jannaschii hypothetical ABC transporter ATP-binding protein MJ1508 SW:YF08_METJA (Q58903) (224 aa) fasta scores: E(): 1e-15, 36.63% id in 202 aa; ABC transporter ATP-binding protein complement(2625338..2626000) Staphylococcus aureus subsp. aureus MRSA252 2859194 YP_041896.1 CDS SAR2545 NC_002952.2 2626346 2627422 R Similar to Lactococcus lactis glutamyl-aminopeptidase PepA SW:PEPA_LACLC (Q48677) (355 aa) fasta scores: E(): 2.7e-39, 37.39% id in 353 aa, and to Bacillus subtilis hypothetical protein YsdC TR:P94521 (EMBL:Z75208) (361 aa) fasta scores: E(): 2.7e-71, 52.08% id in 359 aa; hypothetical protein complement(2626346..2627422) Staphylococcus aureus subsp. aureus MRSA252 2859195 YP_041897.1 CDS SAR2546 NC_002952.2 2627660 2628115 D Similar to Listeria monocytogenes hypothetical lipoprotein precursor SW:YORZ_LISMO (P33385) (153 aa) fasta scores: E(): 7.9e-12, 40.39% id in 151 aa, and to Escherichia coli hypothetical lipoprotein precursor YehR SW:YEHR_ECOLI (P33354) (153 aa) fasta scores: E(): 1.8e-08, 34.89% id in 149 aa; lipoprotein 2627660..2628115 Staphylococcus aureus subsp. aureus MRSA252 2859196 YP_041898.1 CDS SAR2547 NC_002952.2 2628283 2629860 R Similar to Bacillus subtilis YerD TR:O34849 (EMBL:Z99107) (525 aa) fasta scores: E(): 4.4e-112, 56.27% id in 526 aa, and to Pseudomonas aeruginosa hypothetical protein PA3602 TR:Q9HY24 (EMBL:AE004780) (536 aa) fasta scores: E(): 5.4e-45, 35.52% id in 518 aa; hypothetical protein complement(2628283..2629860) Staphylococcus aureus subsp. aureus MRSA252 2859197 YP_041899.1 CDS SAR2548 NC_002952.2 2630056 2630805 D Similar to Bacillus anthracis plasmid pXO2 hypothetical protein pXO2-46 TR:Q9RMY6 (EMBL:AF188935) (221 aa) fasta scores: E(): 0.29, 22.17% id in 230 aa, and to Bacillus subtilis hypothetical protein YybL SW:YYBL_BACSU (P37492) (236 aa) fasta scores: E(): 0.31, 21.88% id in 233 aa; hypothetical protein 2630056..2630805 Staphylococcus aureus subsp. aureus MRSA252 2859198 YP_041900.1 CDS SAR2549 NC_002952.2 2631029 2632222 R Similar to Bacillus subtilis multidrug resistance protein 2 Bmr2 SW:BMR2_BACSU (P39843) (400 aa) fasta scores: E(): 2.7e-07, 22.82% id in 390 aa, and to Bacillus halodurans hypothetical protein BH2079 TR:Q9KB52 (EMBL:AP001514) (392 aa) fasta scores: E(): 1.1e-76, 55.46% id in 384 aa; transporter complement(2631029..2632222) Staphylococcus aureus subsp. aureus MRSA252 2859199 YP_041901.1 CDS opp-1F NC_002952.2 2632234 2632983 R Previously sequenced as Staphylococcus aureus oligopeptide transporter ATPase domain Opp-1F TR:Q9ZGN8 (EMBL:AF076683) (251 aa) fasta scores: E(): 8.5e-88, 100% id in 249 aa. Similar to Escherichia coli peptide transport system ATP-binding protein SapF SW:SAPF_ECOLI (P36637) (268 aa) fasta scores: E(): 4.6e-24, 34.67% id in 248 aa; oligopeptide transporter ATPase complement(2632234..2632983) Staphylococcus aureus subsp. aureus MRSA252 2859180 YP_041902.1 CDS opp-1D NC_002952.2 2632976 2633791 R Previously sequenced as Staphylococcus aureus oligopeptide transporter ATPase domain Opp-1D TR:Q9ZGN9 (EMBL:AF076683) (271 aa) fasta scores: E(): 8.5e-90, 97.41% id in 271 aa. Similar to Bacillus subtilis oligopeptide transport ATP-binding protein OppD SW:OPPD_BACSU (P24136) (358 aa) fasta scores: E(): 6e-32, 42.35% id in 255 aa; oligopeptide transporter ATPase complement(2632976..2633791) Staphylococcus aureus subsp. aureus MRSA252 2859179 YP_041903.1 CDS opp-1C NC_002952.2 2633788 2634657 R Previously sequenced as Staphylococcus aureus oligopeptide transporter membrane permease domain Opp-1C TR:Q9ZGP0 (EMBL:AF076683) (289 aa) fasta scores: E(): 6.6e-107, 100% id in 289 aa. Similar to Escherichia coli nickel ABC transporter permease NikC SW:NIKC_ECOLI (P33592) (277 aa) fasta scores: E(): 6.6e-34, 36.64% id in 262 aa; oligopeptide transporter membrane permease complement(2633788..2634657) Staphylococcus aureus subsp. aureus MRSA252 2859178 YP_041904.1 CDS opp-1B NC_002952.2 2634654 2635589 R Previously sequenced as Staphylococcus aureus oligopeptide transporter membrane permease domain Opp-1B TR:Q9ZGP1 (EMBL:AF076683) (311 aa) fasta scores: E(): 7.1e-116, 99.67% id in 311 aa. Similar to Escherichia coli nickel ABC transporter permease NikB SW:NIKB_ECOLI (P33591) (314 aa) fasta scores: E(): 1.2e-37, 34.82% id in 313 aa; oligopeptide transporter membrane permease complement(2634654..2635589) Staphylococcus aureus subsp. aureus MRSA252 2859177 YP_041905.1 CDS opp-1A NC_002952.2 2635602 2637200 R Previously sequenced as Staphylococcus aureus oligopeptide transporter substrate binding domain Opp-1A TR:Q9ZGP2 (EMBL:AF076683) (486 aa) fasta scores: E(): 1.4e-175, 99.58% id in 486 aa. Similar to Bacillus halodurans nickel transport system BH0567 TR:Q9KFB8 (EMBL:AP001509) (539 aa) fasta scores: E(): 3.1e-62, 38.1% id in 538 aa, and to Escherichia coli nickel-binding periplasmic protein precursor NikA SW:NIKA_ECOLI (P33590) (524 aa) fasta scores: E(): 1.7e-56, 34.82% id in 491 aa. CDS is extended at the N-terminus in comparison previously sequenced protein; oligopeptide transporter substrate binding protein complement(2635602..2637200) Staphylococcus aureus subsp. aureus MRSA252 2859176 YP_041906.1 CDS SAR2555 NC_002952.2 2637343 2638644 R Similar to Bacillus halodurans hypothetical protein BH2073 TR:Q9KB58 (EMBL:AP001514) (436 aa) fasta scores: E(): 2.6e-76, 47.75% id in 423 aa, and to Pseudomonas aeruginosa hypothetical protein PA4835 TR:Q9HUX5 (EMBL:AE004896) (433 aa) fasta scores: E(): 6.2e-41, 31.34% id in 418 aa; hypothetical protein complement(2637343..2638644) Staphylococcus aureus subsp. aureus MRSA252 2859200 YP_041907.1 CDS SAR2556 NC_002952.2 2638637 2639455 R Similar to Bacillus halodurans hypothetical protein BH2072 TR:Q9KB59 (EMBL:AP001514) (264 aa) fasta scores: E(): 7.1e-33, 43.19% id in 257 aa, and to Thermotoga neapolitana hypothetical protein TR:O86951 (EMBL:AJ007446) (258 aa) fasta scores: E(): 0.051, 21.79% id in 257 aa; hypothetical protein complement(2638637..2639455) Staphylococcus aureus subsp. aureus MRSA252 2859201 YP_041908.1 CDS SAR2557 NC_002952.2 2639466 2640287 R Poor database matches. Similar to Bacillus halodurans BH2071 TR:Q9KB60 (EMBL:AP001514) (277 aa) fasta scores: E(): 1.5e-26, 32.73% id in 278 aa; hypothetical protein complement(2639466..2640287) Staphylococcus aureus subsp. aureus MRSA252 2859202 YP_041909.1 CDS SAR2558 NC_002952.2 2640989 2641756 R Similar to Bacillus subtilis hypothetical protein YddR TR:P96655 (EMBL:AB001488) (254 aa) fasta scores: E(): 1.1e-48, 50.39% id in 254 aa, and to Escherichia coli O157:H7 hypothetical protein ECS0400 TR:BAB33823 (EMBL:AP002551) (262 aa) fasta scores: E(): 3.2e-38, 44.01% id in 259 aa; hypothetical protein complement(2640989..2641756) Staphylococcus aureus subsp. aureus MRSA252 2859203 YP_041910.1 CDS SAR2559 NC_002952.2 2641857 2642675 R Similar to Escherichia coli oxidoreductase UcpA SW:UCPA_ECOLI (P37440) (285 aa) fasta scores: E(): 4.9e-25, 35.17% id in 253 aa, and to Bacillus subtilis hypothetical oxidoreductase YxbG SW:YXBG_BACSU (P46331) (262 aa) fasta scores: E(): 7.4e-43, 57.14% id in 210 aa. CDS appears to be truncated at the N-terminus in comparison to the E. coli protein; short chain dehydrogenase complement(2641857..2642675) Staphylococcus aureus subsp. aureus MRSA252 2859204 YP_041911.1 CDS SAR2560 NC_002952.2 2642910 2644448 D Similar to Escherichia coli aminobenzoyl-glutamate transport protein AbgT SW:ABGT_ECOLI (P46133) (510 aa) fasta scores: E(): 4.9e-63, 34.64% id in 508 aa, and to Bacillus halodurans hypothetical protein BH0866 TR:Q9KEI6 (EMBL:AP001510) (513 aa) fasta scores: E(): 2e-91, 46.33% id in 505 aa; transporter 2642910..2644448 Staphylococcus aureus subsp. aureus MRSA252 2859205 YP_041912.1 CDS SAR2561 NC_002952.2 2644560 2644982 R Similar to Bacillus subtilis hypothetical protein YdfG TR:P96684 (EMBL:AB001488) (147 aa) fasta scores: E(): 2.2e-14, 35.82% id in 134 aa, and to Streptomyces coelicolor hypothetical protein SCE6.22c TR:Q9KZR6 (EMBL:AL353832) (157 aa) fasta scores: E(): 3.2e-09, 31.57% id in 133 aa; hypothetical protein complement(2644560..2644982) Staphylococcus aureus subsp. aureus MRSA252 2859206 YP_041913.1 CDS SAR2562 NC_002952.2 2645435 2645848 R No significant database matches. Similar to SAR2566, 78.102% identity (79.259% ungapped) in 137 aa overlap, SAR2565, 75.000% identity (76.119% ungapped) in 136 aa overlap, and to SAR2563, 70.290% identity (71.324% ungapped) in 138 aa overlap; hypothetical protein complement(2645435..2645848) Staphylococcus aureus subsp. aureus MRSA252 2859207 YP_041914.1 CDS SAR2563 NC_002952.2 2645866 2646285 R Poor database matches. Similar to an internal region of Oxytricha fallax hypothetical protein TR:P90560 (EMBL:L39908) (193 aa) fasta scores: E(): 4.5, 25% id in 132 aa. Similar to SAR2565, 86.029% identity (86.029% ungapped) in 136 aa overlap, SAR2566, 70.073% identity (70.073% ungapped) in 137 aa overlap, and to SAR2562, 70.290% identity (71.324% ungapped) in 138 aa overlap; hypothetical protein complement(2645866..2646285) Staphylococcus aureus subsp. aureus MRSA252 2859208 YP_041915.1 CDS SAR2565 NC_002952.2 2646990 2647400 R Poor database matches. Weakly similar to the C-terminal region of Enterococcus faecium hypothetical protein TR:Q47816 (EMBL:U01917) (105 aa) fasta scores: E(): 7.1, 25% id in 76 aa. Similar to SAR2563, 86.029% identity (86.029% ungapped) in 136 aa overlap , SAR2562, 75.000% identity (76.119% ungapped) in 136 aa overlap, and to SAR2566, 72.059% identity (72.059% ungapped) in 136 aa overlap; hypothetical protein complement(2646990..2647400) Staphylococcus aureus subsp. aureus MRSA252 2859210 YP_041916.1 CDS SAR2566 NC_002952.2 2647678 2648100 R Poor database matches. Weakly similar to the C-terminal region of Enterococcus faecium hypothetical protein TR:Q47816 (EMBL:U01917) (105 aa) fasta scores: E(): 6.2, 25.97% id in 77 aa. Similar to SAR2562, 78.102% identity (79.259% ungapped) in 137 aa overlap, SAR2563, 70.073% identity (70.073% ungapped) in 137 aa overlap, and to SAR2565, 72.059% identity (72.059% ungapped) in 136 aa overlap; hypothetical protein complement(2647678..2648100) Staphylococcus aureus subsp. aureus MRSA252 2859211 YP_041917.1 CDS SAR2567 NC_002952.2 2648352 2649047 R Similar to Rhizobium meliloti D-beta-hydroxybutyrate dehydrogenase BdhA SW:BDHA_RHIME (O86034) (258 aa) fasta scores: E(): 5.5e-19, 35.68% id in 227 aa, and to Synechocystis sp hypothetical protein SLR0315 TR:Q55922 (EMBL:D64005) (244 aa) fasta scores: E(): 1.8e-25, 41.49% id in 241 aa; short chain dehydrogenase complement(2648352..2649047) Staphylococcus aureus subsp. aureus MRSA252 2859212 YP_041918.1 CDS SAR2568 NC_002952.2 2649346 2649627 D hypothetical protein 2649346..2649627 Staphylococcus aureus subsp. aureus MRSA252 2859213 YP_041919.1 CDS SAR2569 NC_002952.2 2649885 2650076 R hypothetical protein complement(2649885..2650076) Staphylococcus aureus subsp. aureus MRSA252 2859214 YP_041920.1 CDS SAR2570 NC_002952.2 2650637 2651431 R No significant database matches. Similar to SAR2573, 68.992% identity (68.992% ungapped) in 258 aa overlap, SAR0106, 63.320% identity (64.314% ungapped) in 259 aa overlap, SAR0444, 61.923% identity (62.403% ungapped) in 260 aa overlap; hypothetical protein complement(2650637..2651431) Staphylococcus aureus subsp. aureus MRSA252 2859215 YP_041921.1 CDS SAR2573 NC_002952.2 2652402 2653178 R No significant database matches. Similar to SAR2570, 69.884% identity (70.428% ungapped) in 259 aa overlap, SAR0444, 63.922% identity (64.427% ungapped) in 255 aa overlap, SAR0106, 59.846% identity (61.265% ungapped) in 259 aa overlap, and to SAR0445, 50.373% identity (52.326% ungapped) in 268 aa overlap; lipoprotein complement(2652402..2653178) Staphylococcus aureus subsp. aureus MRSA252 2859217 YP_041922.1 CDS SAR2574 NC_002952.2 2653482 2656343 R Similar to Streptomyces coelicolor helicase SCE20.37 TR:Q9RD88 (EMBL:AL136058) (945 aa) fasta scores: E(): 2.1e-34, 27.06% id in 968 aa. N-terminus is similar to the N-terminal region of Vibrio cholerae helicase-related protein VC0812 TR:Q9KTS6 (EMBL:AE004166) (979 aa) fasta scores: E(): 1.5e-51, 31.74% id in 712 aa; helicase complement(2653482..2656343) Staphylococcus aureus subsp. aureus MRSA252 2859218 YP_041923.1 CDS SAR2575 NC_002952.2 2656345 2656737 R Similar to Escherichia coli CTP pyrophosphohydrolase NudG SW:NUDG_ECOLI (P77788) (135 aa) fasta scores: E(): 5.4e-12, 38.4% id in 125 aa, and to Clostridium acetobutylicum NUDIX (MutT) family hydrolase/pyrophosphatase CAC2828 TR:Q97FB2 (EMBL:AE007780) (128 aa) fasta scores: E(): 2.6e-10, 33.07% id in 127 aa; NUDIX hydrolase complement(2656345..2656737) Staphylococcus aureus subsp. aureus MRSA252 2859219 YP_041924.1 CDS SAR2576 NC_002952.2 2657004 2658662 D Similar to Mycoplasma pirum phosphomannomutase ManB SW:MANB_MYCPI (P47723) (544 aa) fasta scores: E(): 2.5e-35, 28.64% id in 555 aa, and to Bacillus halodurans phosphomannomutase BH1106 TR:Q9KDV5 (EMBL:AP001510) (578 aa) fasta scores: E(): 1.1e-56, 38.4% id in 539 aa; phosphomannomutase 2657004..2658662 Staphylococcus aureus subsp. aureus MRSA252 2859220 YP_041925.1 CDS SAR2577 NC_002952.2 2658946 2659212 D hypothetical protein 2658946..2659212 Staphylococcus aureus subsp. aureus MRSA252 2859221 YP_041926.1 CDS SAR2578 NC_002952.2 2659356 2659664 D Poor database matches. Weakly similar to the C-terminal region of Lysiphlebus testaceipes NADH dehydrogenase 1 TR:O79074 (EMBL:AF069177) (155 aa) fasta scores: E(): 1.7, 24.27% id in 103 aa. Doubtful CDS; hypothetical protein 2659356..2659664 Staphylococcus aureus subsp. aureus MRSA252 2859222 YP_041927.1 CDS gtaB NC_002952.2 2659791 2660657 R Similar to Bacillus subtilis UTP--glucose-1-phosphate uridylyltransferase GtaB SW:GTAB_BACSU (Q05852) (292 aa) fasta scores: E(): 2.8e-74, 70.62% id in 286 aa, and to Bacillus halodurans UTP-glucose-1-phosphate uridylyltransferase BH3717 TR:Q9K6L2 (EMBL:AP001519) (293 aa) fasta scores: E(): 4e-72, 70.28% id in 286 aa; UTP--glucose-1-phosphate uridylyltransferase complement(2659791..2660657) Staphylococcus aureus subsp. aureus MRSA252 2859946 YP_041928.1 CDS fnbA NC_002952.2 2660837 2663734 R Similar to Staphylococcus aureus fibronectin-binding protein precursor FnbA SW:FNBA_STAAU (P14738) (1018 aa) fasta scores: E(): 3.6e-172, 79.15% id in 1022 aa, and to Staphylococcus aureus fibronectin binding protein B FnbB TR:Q53682 (EMBL:X62992) (940 aa) fasta scores: E(): 1.4e-55, 61.77% id in 1015 aa. Probable LPXTG-sorted surface protein. CDS contains two internal deletions relative to the previously sequenced fibronectin-binding protein precursor FnbA (after residues 786 and 840). Deletions occur in regions containing imperfect repeats; fibronectin-binding protein precursor complement(2660837..2663734) Staphylococcus aureus subsp. aureus MRSA252 2860673 YP_041929.1 CDS SAR2581 NC_002952.2 2663869 2664069 R No significant database matches. Possible alternative translational start sites; hypothetical protein complement(2663869..2664069) Staphylococcus aureus subsp. aureus MRSA252 2859223 YP_041930.1 CDS gntP NC_002952.2 2664202 2665560 R Similar to Bacillus licheniformis gluconate permease GntP SW:GNTP_BACLI (P46832) (448 aa) fasta scores: E(): 1.3e-99, 62.19% id in 447 aa, and to Bacillus subtilis gluconate permease GntP SW:GNTP_BACSU (P12012) (448 aa) fasta scores: E(): 4.7e-99, 62.64% id in 447 aa; gluconate permease complement(2664202..2665560) Staphylococcus aureus subsp. aureus MRSA252 2859937 YP_041931.1 CDS gntK NC_002952.2 2665677 2667230 R Similar to Bacillus subtilis gluconokinase GntK SW:GNTK_BACSU (P12011) (513 aa) fasta scores: E(): 1.1e-129, 62.45% id in 506 aa, and to Bacillus licheniformis gluconokinase GntK SW:GNTK_BACLI (P46834) (513 aa) fasta scores: E(): 5.3e-129, 61.85% id in 506 aa; gluconokinase complement(2665677..2667230) Staphylococcus aureus subsp. aureus MRSA252 2859936 YP_041932.1 CDS gntR NC_002952.2 2667255 2667935 R Similar to Bacillus subtilis gluconate operon transcriptional repressor GntR SW:GNTR_BACSU (P10585) (243 aa) fasta scores: E(): 2.5e-37, 46.39% id in 222 aa, and to Bacillus licheniformis gluconate operon transcriptional repressor GntR SW:GNTR_BACLI (P46833) (243 aa) fasta scores: E(): 8.8e-37, 45.49% id in 222 aa; gluconate operon transcriptional repressor complement(2667255..2667935) Staphylococcus aureus subsp. aureus MRSA252 2859938 YP_041933.1 CDS SAR2585 NC_002952.2 2668122 2668853 R Possible pseudogene. Similar to Streptococcus pyogenes transcriptional activator regulator protein SPY1863 TR:Q99Y55 (EMBL:AE006612) (245 aa) fasta scores: E(): 3.4e-20, 32.91% id in 237 aa. N-terminus is similar to the N-terminal region of Bacillus subtilis multidrug-efflux transporter 2 regulator BltR SW:BLTR_BACSU (P39842) (273 aa) fasta scores: E(): 7e-06, 30.57% id in 157 aa. CDS is truncated in comparison to S. aureus orthologues, e.g. SAS2393, due to a possible nonsense mutation after codon 243; MerR family transcriptional regulator complement(2668122..2668853) Staphylococcus aureus subsp. aureus MRSA252 2859224 YP_041934.1 CDS SAR2586 NC_002952.2 2669018 2669710 R Similar to Bacillus subtilis hypothetical protein YwaC SW:YWAC_BACSU (P39583) (210 aa) fasta scores: E(): 6.6e-29, 47.84% id in 186 aa, and to Lactococcus lactis hypothetical protein YijE TR:Q9CH66 (EMBL:AE006321) (224 aa) fasta scores: E(): 5.2e-21, 38.37% id in 185 aa; hypothetical protein complement(2669018..2669710) Staphylococcus aureus subsp. aureus MRSA252 2859225 YP_041935.1 CDS SAR2587 NC_002952.2 2669941 2670429 R No significant database matches. Possible alternative translational start sites; hypothetical protein complement(2669941..2670429) Staphylococcus aureus subsp. aureus MRSA252 2859226 YP_041936.1 CDS SAR2588 NC_002952.2 2670496 2672319 R Poor database matches. Weakly similar to Bacillus subtilis hypothetical protein YvaC TR:O32225 (EMBL:Z99121) (631 aa) fasta scores: E(): 1.6e-27, 25.08% id in 614 aa, and to Escherichia coli hypothetical protein YhfK SW:YHFK_ECOLI (P45537) (696 aa) fasta scores: E(): 2e-07, 24.67% id in 620 aa; hypothetical protein complement(2670496..2672319) Staphylococcus aureus subsp. aureus MRSA252 2859227 YP_041937.1 CDS SAR2589 NC_002952.2 2672796 2674073 R Similar to Mycobacterium smegmatis transporter protein TR:Q9RPH4 (EMBL:AF157643) (413 aa) fasta scores: E(): 3.7e-28, 30.38% id in 418 aa, and to Bacillus subtilis hypothetical transport protein YybO SW:YYBO_BACSU (P37489) (435 aa) fasta scores: E(): 4.2e-27, 25.72% id in 412 aa; transporter protein complement(2672796..2674073) Staphylococcus aureus subsp. aureus MRSA252 2859228 YP_041938.1 CDS SAR2590 NC_002952.2 2674624 2675235 D Similar to Lactococcus lactis alkaline phosphatase Apl TR:Q9CHL6 (EMBL:AE006305) (214 aa) fasta scores: E(): 1.2e-28, 42% id in 200 aa, and to Synechocystis sp alkaline phosphatase-like protein SLR0509 TR:Q55829 (EMBL:D64004) (205 aa) fasta scores: E(): 3.8e-23, 35.78% id in 204 aa; DedA family protein 2674624..2675235 Staphylococcus aureus subsp. aureus MRSA252 2859229 YP_041939.1 CDS SAR2591 NC_002952.2 2675466 2676083 R Similar to Bacillus subtilis hypothetical protein YisU TR:O06730 (EMBL:Y09476) (220 aa) fasta scores: E(): 9e-35, 52.85% id in 193 aa, and to Bacillus halodurans hypothetical protein BH0431 TR:Q9KFP7 (EMBL:AP001508) (200 aa) fasta scores: E(): 9.2e-29, 43.75% id in 192 aa. SAR0857, 63.415% identity (63.415% ungapped) in 205 aa overlap; LysE type translocator complement(2675466..2676083) Staphylococcus aureus subsp. aureus MRSA252 2859230 YP_041940.1 CDS SAR2592 NC_002952.2 2676080 2677060 R Poor database matches. Similar to Bradyrhizobium japonicum hypothetical protein ID867 TR:Q9AMU2 (EMBL:AF322013) (352 aa) fasta scores: E(): 1.4e-22, 30.96% id in 323 aa, and to Caulobacter crescentus hypothetical protein CC3422 TR:Q9A2Y4 (EMBL:AE006002) (329 aa) fasta scores: E(): 1.2e-14, 26.15% id in 302 aa; fatty acid desaturase complement(2676080..2677060) Staphylococcus aureus subsp. aureus MRSA252 2859995 YP_041941.1 CDS SAR2593 NC_002952.2 2677159 2678571 D Similar to Bacillus halodurans transcriptional regulator BH0432 TR:Q9KFP6 (EMBL:AP001508) (482 aa) fasta scores: E(): 2.2e-66, 39.4% id in 467 aa, and to Bacillus subtilis hypothetical protein YdfD TR:P96681 (EMBL:AB001488) (482 aa) fasta scores: E(): 1.1e-56, 35.88% id in 471 aa; transcriptional regulator 2677159..2678571 Staphylococcus aureus subsp. aureus MRSA252 2859996 YP_041942.1 CDS SAR2594 NC_002952.2 2679257 2679952 D Similar to Staphylococcus epidermidis ABC transporter StpA TR:Q54138 (EMBL:Z30586) (231 aa) fasta scores: E(): 8.6e-59, 85.71% id in 231 aa, and to Staphylococcus hominis potential ABC transporter StpB TR:Q54314 (EMBL:Z30587) (231 aa) fasta scores: E(): 8.6e-59, 85.71% id in 231 aa; ABC transporter ATP-binding protein 2679257..2679952 Staphylococcus aureus subsp. aureus MRSA252 2859997 YP_041943.1 CDS SAR2595 NC_002952.2 2679954 2680724 D Similar to Staphylococcus hominis potential membrane spanning protein SmpB TR:Q54315 (EMBL:Z30587) (256 aa) fasta scores: E(): 4.1e-60, 67.57% id in 256 aa, and to Staphylococcus epidermidis membrane spanning protein SmpA TR:Q54139 (EMBL:Z30586) (256 aa) fasta scores: E(): 6.2e-60, 66.4% id in 256 aa; hypothetical protein 2679954..2680724 Staphylococcus aureus subsp. aureus MRSA252 2859998 YP_041944.1 CDS SAR2596 NC_002952.2 2681229 2683193 D Similar to Bacillus subtilis hypothetical protein YydE TR:Q45597 (EMBL:D78193) (671 aa) fasta scores: E(): 8.8e-178, 69.45% id in 645 aa, and to Lactobacillus rhamnosus hypothetical protein TR:AAK64293 (EMBL:AF323526) (656 aa) fasta scores: E(): 6.1e-131, 53.39% id in 633 aa; hypothetical protein 2681229..2683193 Staphylococcus aureus subsp. aureus MRSA252 2859999 YP_041945.1 CDS SAR2597 NC_002952.2 2683537 2684616 D Similar to Bacillus subtilis hypothetical protein YkvI TR:O31674 (EMBL:Z99111) (347 aa) fasta scores: E(): 1.5e-17, 25% id in 348 aa, and to the N-terminal region of Corynebacterium glutamicum branched-chain amino acid transport system carrier protein BrnQ SW:BRNQ_CORGL (O06754) (426 aa) fasta scores: E(): 0.12, 22.35% id in 349 aa; hypothetical protein 2683537..2684616 Staphylococcus aureus subsp. aureus MRSA252 2858890 YP_041946.1 CDS SAR2598 NC_002952.2 2684721 2685317 R Similar to Bacillus halodurans hypothetical protein BH2174 TR:Q9KAW2 (EMBL:AP001514) (204 aa) fasta scores: E(): 7.4e-29, 41.93% id in 186 aa, and to Bacillus subtilis hypothetical protein YolF TR:O34842 (EMBL:AF006665) (200 aa) fasta scores: E(): 1.2e-25, 41.93% id in 186 aa; phospholipase/carboxylesterase complement(2684721..2685317) Staphylococcus aureus subsp. aureus MRSA252 2858891 YP_041947.1 CDS SAR2599 NC_002952.2 2685336 2686304 R Similar to Flavobacterium sp 2,6-dichloro-p-hydroquinone 1,2-dioxygenase PcpA TR:Q9ZBB0 (EMBL:M55159) (320 aa) fasta scores: E(): 5.6e-19, 29.46% id in 319 aa, and to Bacillus halodurans hypothetical protein BH2175 TR:Q9KAW1 (EMBL:AP001514) (327 aa) fasta scores: E(): 1.7e-58, 48.75% id in 320 aa; dioxygenase complement(2685336..2686304) Staphylococcus aureus subsp. aureus MRSA252 2858892 YP_041948.1 CDS SAR2600 NC_002952.2 2686382 2686816 R Similar to Bacillus subtilis hypothetical protein YkvE TR:O31672 (EMBL:Z99111) (145 aa) fasta scores: E(): 1.2e-16, 41.79% id in 134 aa, and to Streptococcus pyogenes transcriptional regulator SPY1960 TR:Q99XY5 (EMBL:AE006619) (142 aa) fasta scores: E(): 1.6e-11, 35.76% id in 137 aa; MarR family regulatory protein complement(2686382..2686816) Staphylococcus aureus subsp. aureus MRSA252 2858893 YP_041949.1 CDS SAR2601 NC_002952.2 2687033 2687326 D Similar to Escherichia coli hypothetical protein YjdJ SW:YJDJ_ECOLI (P39274) (90 aa) fasta scores: E(): 3.7e-11, 45.45% id in 88 aa, and to Lactococcus lactis YjdJ-like protein TR:O69438 (EMBL:Y13384) (105 aa) fasta scores: E(): 4.3e-06, 39.32% id in 89 aa; acetyltransferase (GNAT) family protein 2687033..2687326 Staphylococcus aureus subsp. aureus MRSA252 2858894 YP_041950.1 CDS SAR2602 NC_002952.2 2687501 2688307 D Similar to Bacillus halodurans hypothetical protein BH3305 TR:Q9K7Q6 (EMBL:AP001518) (286 aa) fasta scores: E(): 5.3e-34, 41.15% id in 243 aa, and to Rhizobium loti hypothetical protein MLR0078 TR:BAB47738 (EMBL:AP002994) (270 aa) fasta scores: E(): 1.5e-29, 35.45% id in 251 aa; glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein 2687501..2688307 Staphylococcus aureus subsp. aureus MRSA252 2858895 YP_041951.1 CDS ddh NC_002952.2 2689369 2690361 D catalyzes the formation of pyruvate from lactate; D-lactate dehydrogenase 2689369..2690361 Staphylococcus aureus subsp. aureus MRSA252 2859266 YP_041952.1 CDS SAR2607 NC_002952.2 2691460 2692260 R Similar to Escherichia coli hypothetical protein YbjI SW:YBJI_ECOLI (P75809) (271 aa) fasta scores: E(): 6.3e-28, 36.7% id in 267 aa, and to Escherichia coli hypothetical protein YbiV SW:YBIV_ECOLI (P75792) (271 aa) fasta scores: E(): 1.3e-26, 36.84% id in 266 aa; haloacid dehalogenase-like hydrolase complement(2691460..2692260) Staphylococcus aureus subsp. aureus MRSA252 2858898 YP_041953.1 CDS srtA NC_002952.2 2692490 2693110 R Previously sequenced as Staphylococcus aureus, peptidoglycan-anchored surface protein processing enzyme, sortase SrtA TR:Q9S446 (EMBL:AF162687) (206 aa) fasta scores: E(): 4e-71, 99.02% id in 206 aa. Similar to Bacillus halodurans hypothetical protein BH2015 TR:Q9KBB3 (EMBL:AP001514) (193 aa) fasta scores: E(): 5.4e-07, 29.83% id in 181 aa; sortase complement(2692490..2693110) Staphylococcus aureus subsp. aureus MRSA252 2859502 YP_041954.1 CDS SAR2609 NC_002952.2 2693304 2693795 D Similar to Streptomyces coelicolor phosphinothricin N-acetyltransferase Bar SW:PAT_STRCO (P21861) (171 aa) fasta scores: E(): 5.6e-14, 33.74% id in 163 aa, and to Pseudomonas aeruginosa hypothetical protein PA4866 TR:Q9HUU7 (EMBL:AE004900) (172 aa) fasta scores: E(): 3.1e-26, 46.58% id in 161 aa; acetyltransferase (GNAT) family protein 2693304..2693795 Staphylococcus aureus subsp. aureus MRSA252 2858899 YP_041955.1 CDS SAR2610 NC_002952.2 2694594 2695493 R Similar to Peptostreptococcus asaccharolyticus L-serine dehydratase, alpha chain SdhA SW:SDHA_PEPAS (P33073) (292 aa) fasta scores: E(): 1.7e-38, 44.4% id in 286 aa, and to Bacillus subtilis probable L-serine dehydratase, alpha chain YlpA SW:SDHA_BACSU (O34607) (300 aa) fasta scores: E(): 3.1e-58, 58.56% id in 292 aa; L-serine dehydratase subunit alpha complement(2694594..2695493) Staphylococcus aureus subsp. aureus MRSA252 2858900 YP_041956.1 CDS SAR2611 NC_002952.2 2695507 2696187 R N-terminus is similar to the N-terminal region of Peptostreptococcus asaccharolyticus L-serine dehydratase, beta chain SdhB SW:SDHB_PEPAS (P33074) (222 aa) fasta scores: E(): 2.6e-17, 44.89% id in 147 aaSimilar to the full length Bacillus subtilis probable L-serine dehydratase, beta chain YloW SW:SDHB_BACSU (O34635) (220 aa) fasta scores: E(): 7.5e-23, 42.03% id in 226 aa; L-serine dehydratase subunit beta complement(2695507..2696187) Staphylococcus aureus subsp. aureus MRSA252 2858901 YP_041957.1 CDS SAR2612 NC_002952.2 2696190 2697233 R Similar to Streptococcus pyogenes regulatory protein SPY0146 TR:Q9A1Q9 (EMBL:AE006484) (339 aa) fasta scores: E(): 5.5e-45, 43.5% id in 331 aa, and to an internal region of Streptococcus pyogenes sucrose-specific PTS permease, enzyme II SPY1815 TR:Q99Y91 (EMBL:AE006608) (620 aa) fasta scores: E(): 0.0098, 25.51% id in 341 aa; hypothetical protein complement(2696190..2697233) Staphylococcus aureus subsp. aureus MRSA252 2858902 YP_041958.1 CDS SAR2613 NC_002952.2 2697783 2697986 D hypothetical protein 2697783..2697986 Staphylococcus aureus subsp. aureus MRSA252 2858903 YP_041959.1 CDS SAR2614 NC_002952.2 2698179 2699105 D Similar to Bacillus halodurans hypothetical protein BH0725 TR:Q9KEX4 (EMBL:AP001509) (312 aa) fasta scores: E(): 2.2e-47, 45.94% id in 296 aa, and to Bacillus subtilis hypothetical protein YdeD SW:YDED_BACSU (P96661) (319 aa) fasta scores: E(): 9.1e-46, 44.26% id in 305 aa; hypothetical protein 2698179..2699105 Staphylococcus aureus subsp. aureus MRSA252 2858904 YP_041960.1 CDS SAR2615 NC_002952.2 2699186 2700154 R Similar to Streptococcus pyogenes esterase SPY1718 TR:Q99YG3 (EMBL:AE006601) (328 aa) fasta scores: E(): 7.6e-30, 33.66% id in 300 aa, and to Streptococcus pyogenes esterase SPY1308 TR:Q99ZB0 (EMBL:AE006570) (327 aa) fasta scores: E(): 2.7e-24, 29.28% id in 321 aa; hypothetical protein complement(2699186..2700154) Staphylococcus aureus subsp. aureus MRSA252 2858905 YP_041961.1 CDS SAR2616 NC_002952.2 2700275 2700631 R Similar to Schizosaccharomyces pombe thioredoxin II TRX2 SW:TRX2_SCHPO (O14463) (102 aa) fasta scores: E(): 0.0049, 25.3% id in 83 aa, and to Bacillus subtilis hypothetical protein YdfQ TR:P96695 (EMBL:AB001488) (112 aa) fasta scores: E(): 2.8e-12, 38.38% id in 99 aa; hypothetical protein complement(2700275..2700631) Staphylococcus aureus subsp. aureus MRSA252 2858906 YP_041962.1 CDS SAR2617 NC_002952.2 2700673 2701083 R Similar to Bacillus halodurans hypothetical protein BH2288 TR:Q9KAJ9 (EMBL:AP001515) (143 aa) fasta scores: E(): 0.0003, 29.5% id in 122 aa, and to Vibrio cholerae hypothetical protein VC1938 TR:Q9KQR0 (EMBL:AE004269) (149 aa) fasta scores: E(): 0.00043, 26.98% id in 126 aa; hypothetical protein complement(2700673..2701083) Staphylococcus aureus subsp. aureus MRSA252 2858907 YP_041963.1 CDS glcB NC_002952.2 2701463 2703529 R Similar to Bacillus subtilis PTS system, glucose-specific IIABC component PtsG SW:PTGA_BACSU (P20166) (699 aa) fasta scores: E(): 3.4e-121, 59.29% id in 683 aa, and to Staphylococcus carnosus PTS system, glucose-specific IIABC component GlcB TR:Q53922 (EMBL:X93360) (692 aa) fasta scores: E(): 2e-193, 74.09% id in 687 aa. Similar to SAR0190, 59.584% identity (61.692% ungapped) in 673 aa overlap; PTS system, glucose-specific IIABC component complement(2701463..2703529) Staphylococcus aureus subsp. aureus MRSA252 2859917 YP_041964.1 CDS SAR2619 NC_002952.2 2703829 2705568 R catalyzes the formation of acetyl phosphate from pyruvate; pyruvate oxidase complement(2703829..2705568) Staphylococcus aureus subsp. aureus MRSA252 2858908 YP_041965.1 CDS SAR2620 NC_002952.2 2705608 2706297 R Similar to Bacillus halodurans hypothetical protein BH3268 TR:Q9K7U1 (EMBL:AP001518) (227 aa) fasta scores: E(): 5e-24, 36.23% id in 218 aa, and to Escherichia coli hypothetical protein YohK SW:YOHK_ECOLI (P33373) (231 aa) fasta scores: E(): 3.7e-23, 35.29% id in 221 aa; hypothetical protein complement(2705608..2706297) Staphylococcus aureus subsp. aureus MRSA252 2858909 YP_041966.1 CDS SAR2621 NC_002952.2 2706290 2706685 R Similar to Bacillus subtilis hypothetical protein YwbH SW:YWBH_BACSU (P39591) (128 aa) fasta scores: E(): 1.9e-09, 31.25% id in 128 aa, and to Lactococcus lactis hypothetical protein YhhD TR:Q9CHG9 (EMBL:AE006310) (134 aa) fasta scores: E(): 8.4e-09, 35.39% id in 113 aa; hypothetical protein complement(2706290..2706685) Staphylococcus aureus subsp. aureus MRSA252 2858910 YP_041967.1 CDS SAR2622 NC_002952.2 2706899 2707777 R Similar to Bacillus subtilis transcriptional regulatory protein GltC SW:GLTC_BACSU (P20668) (300 aa) fasta scores: E(): 4.2e-20, 26.89% id in 290 aa, and to Bacillus subtilis hypothetical transcriptional regulator YwbI SW:YWBI_BACSU (P39592) (301 aa) fasta scores: E(): 8.5e-40, 38.01% id in 292 aa; LysR family regulatory protein complement(2706899..2707777) Staphylococcus aureus subsp. aureus MRSA252 2858911 YP_041968.1 CDS SAR2623 NC_002952.2 2707944 2708162 D hypothetical protein 2707944..2708162 Staphylococcus aureus subsp. aureus MRSA252 2858912 YP_041969.1 CDS SAR2624 NC_002952.2 2708550 2708981 D Similar to the C-terminal regions of Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 5.7e-13, 39.83% id in 118 aa, and Staphylococcus carnosus hypothetical protein SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 1.4e-13, 40.67% id in 118 aa; hypothetical protein 2708550..2708981 Staphylococcus aureus subsp. aureus MRSA252 2858913 YP_041970.1 CDS mvaA NC_002952.2 2709121 2710401 R Previously sequenced as Staphylococcus aureus 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase MvaA TR:Q9FD86 (EMBL:AF290086) (425 aa) fasta scores: E(): 1.2e-148, 97.64% id in 425 aa. Similar to Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-coenzyme A reductase MvaA SW:MVAA_PSEMV (P13702) (428 aa) fasta scores: E(): 3.2e-51, 40.41% id in 433 aa; 3-hydroxy-3-methylglutaryl-coenzyme A reductase complement(2709121..2710401) Staphylococcus aureus subsp. aureus MRSA252 2861328 YP_041971.1 CDS mvaS NC_002952.2 2710656 2711822 D Previously sequenced as Staphylococcus aureus 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase MvaS TR:Q9FD87 (EMBL:AF290086) (388 aa) fasta scores: E(): 5.2e-149, 98.45% id in 388 aa. Similar to Staphylococcus haemolyticus HMG-CoA synthase MvaS TR:Q9FD82 (EMBL:AF290088) (388 aa) fasta scores: E(): 6.5e-127, 81.95% id in 388 aa; 3-hydroxy-3-methylglutaryl coenzyme A synthase 2710656..2711822 Staphylococcus aureus subsp. aureus MRSA252 2861332 YP_041972.1 CDS SAR2627 NC_002952.2 2711993 2712514 R Similar to Bacillus subtilis methylated-DNA--protein-cysteine methyltransferase Ogt SW:OGT_BACSU (P11742) (165 aa) fasta scores: E(): 6.2e-14, 36.99% id in 173 aa, and to Haemophilus influenzae methylated-DNA--protein-cysteine methyltransferase HI0402 SW:OGT_HAEIN (P44687) (190 aa) fasta scores: E(): 9.7e-25, 45.19% id in 177 aa; 6-O-methylguanine DNA methyltransferase complement(2711993..2712514) Staphylococcus aureus subsp. aureus MRSA252 2858914 YP_041973.1 CDS clpL NC_002952.2 2712877 2714982 D Similar to Lactococcus lactis ATP-dependent protease ATP-binding subunit ClpL SW:CLPL_LACLA (Q06716) (763 aa) fasta scores: E(): 3.3e-125, 54.81% id in 706 aa, and to Streptococcus pyogenes ATP-dependent Clp proteinase SPY0888 TR:Q9A086 (EMBL:AE006538) (699 aa) fasta scores: E(): 1.4e-144, 63.15% id in 692 aa. CDS contains fewer amino acids at the N-terminus in comparison to the Lactococcus lactis orthologue; ATP-dependent protease ATP-binding subunit ClpL 2712877..2714982 Staphylococcus aureus subsp. aureus MRSA252 2859235 YP_041974.1 CDS SAR2629 NC_002952.2 2715052 2715222 R hypothetical protein complement(2715052..2715222) Staphylococcus aureus subsp. aureus MRSA252 2858915 YP_041975.1 CDS SAR2630 NC_002952.2 2715235 2717229 R Similar to Escherichia coli ferrous iron transport protein B FeoB SW:FEOB_ECOLI (P33650) (773 aa) fasta scores: E(): 4.1e-69, 34.81% id in 718 aa, and to Methanococcus jannaschii ferrous iron transport protein B homologue MJ0566 SW:FEOB_METJA (Q57986) (668 aa) fasta scores: E(): 7.5e-89, 40.05% id in 679 aa; ferrous iron transport protein B complement(2715235..2717229) Staphylococcus aureus subsp. aureus MRSA252 2858916 YP_041976.1 CDS SAR2631 NC_002952.2 2717241 2717468 R hypothetical protein complement(2717241..2717468) Staphylococcus aureus subsp. aureus MRSA252 2858917 YP_041977.1 CDS SAR2632 NC_002952.2 2717683 2720172 R Similar to Bacillus subtilis YdfJ TR:P96687 (EMBL:AB001488) (724 aa) fasta scores: E(): 6.9e-108, 45.46% id in 717 aa, and to Streptomyces coelicolor integral membrane protein SC8G12.12 TR:Q9KYZ3 (EMBL:AL355753) (739 aa) fasta scores: E(): 2.9e-88, 39.2% id in 727 aa; transport protein complement(2717683..2720172) Staphylococcus aureus subsp. aureus MRSA252 2858918 YP_041978.1 CDS SAR2633 NC_002952.2 2720317 2720865 D Similar to Streptococcus pyogenes transcriptional regulator SPY1258 TR:Q99ZE9 (EMBL:AE006565) (180 aa) fasta scores: E(): 7.2e-06, 25.69% id in 179 aa, and to Lactococcus lactis transcriptional regulator YxcB TR:Q9CDI1 (EMBL:AE006453) (204 aa) fasta scores: E(): 2.5e-05, 23.4% id in 188 aa; TetR family regulatory protein 2720317..2720865 Staphylococcus aureus subsp. aureus MRSA252 2858919 YP_041979.1 CDS SAR2634 NC_002952.2 2721221 2722765 R catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate; 1-pyrroline-5-carboxylate dehydrogenase complement(2721221..2722765) Staphylococcus aureus subsp. aureus MRSA252 2858920 YP_041980.1 CDS SAR2635 NC_002952.2 2722955 2723554 R Similar to Escherichia coli galactoside O-acetyltransferase LacA SW:THGA_ECOLI (P07464) (203 aa) fasta scores: E(): 9.1e-28, 43.01% id in 186 aa, and to Streptococcus pyogenes acetyltransferase SPY1065 TR:Q99ZU6 (EMBL:AE006551) (188 aa) fasta scores: E(): 1.5e-42, 56.45% id in 186 aa; acetyltransferase complement(2722955..2723554) Staphylococcus aureus subsp. aureus MRSA252 2858921 YP_041981.1 CDS SAR2636 NC_002952.2 2723784 2723984 D Poor database matches. Similar to the N-terminal regions of Streptomyces coelicolor hypothetical protein SCP8.13 TR:Q9FBK8 (EMBL:AL390975) (161 aa) fasta scores: E(): 8.9, 31.74% id in 63 aa; hypothetical protein 2723784..2723984 Staphylococcus aureus subsp. aureus MRSA252 2858922 YP_041982.1 CDS copA NC_002952.2 2724224 2726632 D Similar to Enterococcus hirae probable copper importing ATPase A CopA SW:COPA_ENTHR (P32113) (727 aa) fasta scores: E(): 9.8e-120, 50.34% id in 725 aa, and to Bacillus halodurans copper-transporting ATPase BH0557 TR:Q9KFC7 (EMBL:AP001508) (806 aa) fasta scores: E(): 5.6e-154, 55.15% id in 805 aa. CDS contains extra amino acids at the N-terminus in comparison to the Enterococcus hirae orthologue; copper importing ATPase A 2724224..2726632 Staphylococcus aureus subsp. aureus MRSA252 2859243 YP_041983.1 CDS SAR2639 NC_002952.2 2727453 2727659 D Similar to Enterococcus hirae activator of copYZAB CopZ SW:COPZ_ENTHR (Q47840) (69 aa) fasta scores: E(): 4.4e-05, 36.92% id in 65 aa, and to Bacillus subtilis hypothetical protein YvgY TR:O32221 (EMBL:Z99121) (69 aa) fasta scores: E(): 4.5e-12, 56.71% id in 67 aa; heavy-metal-associated protein 2727453..2727659 Staphylococcus aureus subsp. aureus MRSA252 2858923 YP_041984.1 CDS SAR2640 NC_002952.2 2727749 2728747 R catalyzes the formation of pyruvate from lactate; D-lactate dehydrogenase complement(2727749..2728747) Staphylococcus aureus subsp. aureus MRSA252 2858924 YP_041985.1 CDS SAR2641 NC_002952.2 2728770 2729924 R Similar to Bacillus subtilis probable aspartate aminotransferase YwfG SW:AAT2_BACSU (P39643) (399 aa) fasta scores: E(): 5.2e-52, 39.52% id in 382 aa, and to Bacillus halodurans aspartate aminotransferase BH1060 TR:Q9KE01 (EMBL:AP001510) (395 aa) fasta scores: E(): 5.9e-52, 39.48% id in 385 aa; aminotransferase complement(2728770..2729924) Staphylococcus aureus subsp. aureus MRSA252 2858925 YP_041986.1 CDS crtN NC_002952.2 2730351 2731859 R Previously sequenced as Staphylococcus aureus squalene synthase CrtN TR:O07855 (EMBL:X73889) (506 aa) fasta scores: E(): 1.1e-184, 97% id in 500 aa. Similar to Erwinia herbicola phytoene dehydrogenase CrtI SW:CRTI_ERWHE (P22871) (492 aa) fasta scores: E(): 2.1e-47, 32.47% id in 502 aa; squalene synthase complement(2730351..2731859) Staphylococcus aureus subsp. aureus MRSA252 2859245 YP_041987.1 CDS SAR2645 NC_002952.2 2732771 2733898 R Similar to Deinococcus radiodurans conserved hypothetical protein DR0089 TR:Q9RY61 (EMBL:AE001872) (358 aa) fasta scores: E(): 6.6e-09, 24.85% id in 334 aa, and to Pyrococcus abyssi hyaluronan synthase related protein PAB1314 TR:Q9UYC7 (EMBL:AJ248288) (350 aa) fasta scores: E(): 0.00076, 22.28% id in 332 aa; glycosyl transferase complement(2732771..2733898) Staphylococcus aureus subsp. aureus MRSA252 2858926 YP_041988.1 CDS SAR2646 NC_002952.2 2733904 2735397 R Similar to Myxococcus xanthus phytoene dehydrogenase CarA2 SW:CRTJ_MYXXA (P54979) (517 aa) fasta scores: E(): 2.8e-42, 29.96% id in 494 aa, and to Erwinia herbicola phytoene dehydrogenase CrtI SW:CRTI_ERWHE (P22871) (492 aa) fasta scores: E(): 5.3e-38, 27.55% id in 490 aa; phytoene dehydrogenase related protein complement(2733904..2735397) Staphylococcus aureus subsp. aureus MRSA252 2858927 YP_041989.1 CDS SAR2647 NC_002952.2 2735390 2735887 R Poor database matches. Weakly similar to Pyrococcus abyssi hypothetical protein PAB1170 TR:Q9UXS9 (EMBL:AJ248288) (220 aa) fasta scores: E(): 8.3, 24.34% id in 152 aa; hypothetical protein complement(2735390..2735887) Staphylococcus aureus subsp. aureus MRSA252 2860560 YP_041990.1 CDS ssaA NC_002952.2 2736059 2736826 R Similar to Staphylococcus epidermidis secretory antigen precursor SsaA TR:Q9KJT6 (EMBL:AF162275) (257 aa) fasta scores: E(): 2.4e-65, 75.19% id in 258 aa, and to Staphylococcus carnosus SceB precursor SceB TR:O54487 (EMBL:U96107) (263 aa) fasta scores: E(): 2.5e-54, 63.49% id in 263 aa. Similar to SAR2383, 75.093% identity (79.216% ungapped) in 269 aa overlap; secretory antigen precursor complement(2736059..2736826) Staphylococcus aureus subsp. aureus MRSA252 2859504 YP_041991.1 CDS SAR2649 NC_002952.2 2737187 2738998 R Similar to Bacillus subtilis hypothetical protein YrhL TR:O05402 (EMBL:U93874) (634 aa) fasta scores: E(): 6.9e-54, 38.86% id in 633 aa, and to Lactococcus lactis hypothetical protein YvhB TR:Q9CDV4 (EMBL:AE006439) (605 aa) fasta scores: E(): 6.5e-42, 31.78% id in 604 aa. Similar to SAR0937, 57.475% identity (58.545% ungapped) in 602 aa overlap; hypothetical protein complement(2737187..2738998) Staphylococcus aureus subsp. aureus MRSA252 2860561 YP_041992.1 CDS isaA NC_002952.2 2739685 2740386 R Similar to Staphylococcus aureus immunodominant antigen A IsaA TR:Q9LAB6 (EMBL:AF144681) (233 aa) fasta scores: E(): 4.7e-78, 99.57% id in 233 aa, and to Staphylococcus carnosus SceA precursor SceA TR:O54494 (EMBL:AF109218) (237 aa) fasta scores: E(): 2.5e-14, 34.8% id in 227 aa; immunodominant antigen A complement(2739685..2740386) Staphylococcus aureus subsp. aureus MRSA252 2859671 YP_041993.1 CDS SAR2651 NC_002952.2 2740994 2742049 R Similar to Treponema pallidum regulatory protein TP0038 TR:Q56343 (EMBL:AE001189) (350 aa) fasta scores: E(): 1.4e-52, 44.89% id in 343 aa, and to Streptococcus pyogenes probable regulatory protein SPY0851 TR:Q9A0B4 (EMBL:AE006535) (352 aa) fasta scores: E(): 4.9e-45, 42.61% id in 359 aa; hypothetical protein complement(2740994..2742049) Staphylococcus aureus subsp. aureus MRSA252 2860562 YP_041994.1 CDS SAR2652 NC_002952.2 2742460 2743029 D Similar to Lactococcus lactis transcriptional regulator YxcB TR:Q9CDI1 (EMBL:AE006453) (204 aa) fasta scores: E(): 2.3e-09, 29.5% id in 183 aa, and to Bacillus subtilis hypothetical protein YxbF SW:YXBF_BACSU (P46330) (380 aa) fasta scores: E(): 5.2e-06, 30.6% id in 183 aa; TetR family regulatory protein 2742460..2743029 Staphylococcus aureus subsp. aureus MRSA252 2860563 YP_041995.1 CDS SAR2653 NC_002952.2 2743227 2743727 D No significant database matches. Possible alternative translational start sites; hypothetical protein 2743227..2743727 Staphylococcus aureus subsp. aureus MRSA252 2860564 YP_041996.1 CDS SAR2654 NC_002952.2 2743947 2744177 D Similar to Bacillus subtilis hypothetical protein YnzC TR:O31818 (EMBL:Z99113) (77 aa) fasta scores: E(): 7.1e-07, 49.15% id in 59 aa, and to Lactococcus lactis hypothetical protein YlaC TR:Q9CGJ9 (EMBL:AE006342) (80 aa) fasta scores: E(): 2.3e-06, 42.85% id in 70 aa; hypothetical protein 2743947..2744177 Staphylococcus aureus subsp. aureus MRSA252 2860565 YP_041997.1 CDS SAR2655 NC_002952.2 2744340 2744717 R Similar to Escherichia coli, and lactoylglutathione lyase GloA SW:LGUL_ECOLI (Q59384) (135 aa) fasta scores: E(): 0.52, 27.86% id in 122 aa, and to Bacillus halodurans hypothetical protein BH3119 TR:Q9K887 (EMBL:AP001517) (134 aa) fasta scores: E(): 1.6e-07, 33.6% id in 125 aa; glyoxalase complement(2744340..2744717) Staphylococcus aureus subsp. aureus MRSA252 2860566 YP_041998.1 CDS SAR2656 NC_002952.2 2744734 2745555 R Similar to Streptomyces coelicolor actinorhodin biosynthetic protein ActVA 4 TR:Q53906 (EMBL:X58833) (294 aa) fasta scores: E(): 4.6e-20, 34.15% id in 284 aa, and to Rhizobium loti hypothetical protein MLL7605 protein mll7605 TR:BAB54033 (EMBL:AP003012) (294 aa) fasta scores: E(): 9.6e-12, 25.79% id in 283 aa; hypothetical protein complement(2744734..2745555) Staphylococcus aureus subsp. aureus MRSA252 2860567 YP_041999.1 CDS SAR2657 NC_002952.2 2745574 2745873 R Poor database matches. Similar to the C-terminal region of Deinococcus radiodurans hypothetical protein DR1049 TR:Q9RVI0 (EMBL:AE001956) (124 aa) fasta scores: E(): 1.7, 32% id in 100 aa; hypothetical protein complement(2745574..2745873) Staphylococcus aureus subsp. aureus MRSA252 2860568 YP_042000.1 CDS SAR2658 NC_002952.2 2746004 2746561 D No significant database matches to the full length CDS. Similar to Bacillus halodurans transcriptional regulator BH2145 TR:Q9KAZ1 (EMBL:AP001514) (193 aa) fasta scores: E(): 0.00041, 30.76% id in 130 aa, and to Mycobacterium tuberculosis transcriptional regulator MTV030.10c TR:O53612 (EMBL:AL021428) (189 aa) fasta scores: E(): 0.0013, 28.7% id in 108 aa; TetR family regulatory protein 2746004..2746561 Staphylococcus aureus subsp. aureus MRSA252 2860569 YP_042001.1 CDS SAR2659 NC_002952.2 2746554 2747258 D Similar to Rhizobium meliloti acetoacetyl-CoA reductase PhbB SW:PHBB_RHIME (P50205) (241 aa) fasta scores: E(): 8.8e-10, 29.71% id in 249 aa, and to Streptomyces coelicolor short chain oxidoreductase SCM1.23c TR:Q9RD20 (EMBL:AL133422) (235 aa) fasta scores: E(): 1.1e-31, 44.87% id in 234 aa; short chain dehydrogenase 2746554..2747258 Staphylococcus aureus subsp. aureus MRSA252 2860570 YP_042002.1 CDS SAR2660 NC_002952.2 2747356 2748366 D Similar to Synechocystis sp hypothetical protein SLR0619 TR:Q55861 (EMBL:D64004) (348 aa) fasta scores: E(): 1.1e-31, 35.34% id in 348 aa. Weakly similar to Rhizobium loti hypothetical protein MLR9221 TR:BAB54605 (EMBL:AP003015) (357 aa) fasta scores: E(): 0.0003, 20.51% id in 312 aa; hypothetical protein 2747356..2748366 Staphylococcus aureus subsp. aureus MRSA252 2860571 YP_042003.1 CDS SAR2661 NC_002952.2 2748386 2749216 D Similar to Bacillus subtilis hypothetical protein YraK TR:O07937 (EMBL:X92868) (229 aa) fasta scores: E(): 3.7e-09, 28.21% id in 241 aa, and to Streptomyces rishiriensis hydrolase CouN7 TR:Q9F8U0 (EMBL:AF235050) (281 aa) fasta scores: E(): 2.8e-08, 26.25% id in 278 aa; hydrolase 2748386..2749216 Staphylococcus aureus subsp. aureus MRSA252 2860572 YP_042004.1 CDS SAR2662 NC_002952.2 2749363 2750253 R Similar to Bacillus halodurans BH0366 TR:Q9KFV5 (EMBL:AP001508) (311 aa) fasta scores: E(): 2e-23, 29.77% id in 309 aa, and to Deinococcus radiodurans CobW protein DR2408 TR:Q9RRS7 (EMBL:AE002071) (320 aa) fasta scores: E(): 1.9e-18, 28.28% id in 304 aa; cobalamin synthesis protein/P47K family protein complement(2749363..2750253) Staphylococcus aureus subsp. aureus MRSA252 2860573 YP_042005.1 CDS SAR2663 NC_002952.2 2750353 2751699 R No significant database matches to the full length CDS. C-terminus is weakly similar to the C-terminal region of Archaeoglobus fulgidus iron (II) transporter (FeoB-1) AF0246 TR:O29993 (EMBL:AE001089) (639 aa) fasta scores: E(): 4.1e-11, 19.89% id in 372 aa. Internal region is weakly similar to an internal region of Escherichia coli ferrous iron transport protein B FeoB SW:FEOB_ECOLI (P33650) (773 aa) fasta scores: E(): 2e-07, 20.71% id in 280 aa; hypothetical protein complement(2750353..2751699) Staphylococcus aureus subsp. aureus MRSA252 2860574 YP_042006.1 CDS SAR2664 NC_002952.2 2751687 2752793 R Similar to Bacillus subtilis hypothetical protein YpdA SW:YPDA_BACSU (P50736) (324 aa) fasta scores: E(): 7.2e-08, 25.56% id in 352 aa. N-terminus is similar to the N-terminal region of Onchocerca volvulus glutathione reductase TR:O01412 (EMBL:Y11830) (462 aa) fasta scores: E(): 0.32, 23.38% id in 201 aa; hypothetical protein complement(2751687..2752793) Staphylococcus aureus subsp. aureus MRSA252 2860575 YP_042007.1 CDS SAR2665 NC_002952.2 2753126 2753422 R Similar to Bacillus halodurans BH0980 TR:Q9KE76 (EMBL:AP001510) (102 aa) fasta scores: E(): 4.7e-18, 56.25% id in 96 aa, and to Bacillus pseudofirmus hypothetical protein TR:O50571 (EMBL:U89914) (93 aa) fasta scores: E(): 0.038, 32.43% id in 74 aa; hypothetical protein complement(2753126..2753422) Staphylococcus aureus subsp. aureus MRSA252 2860576 YP_042008.1 CDS SAR2666 NC_002952.2 2753410 2753778 R hypothetical protein complement(2753410..2753778) Staphylococcus aureus subsp. aureus MRSA252 2860577 YP_042009.1 CDS SAR2667 NC_002952.2 2753793 2754071 R hypothetical protein complement(2753793..2754071) Staphylococcus aureus subsp. aureus MRSA252 2860578 YP_042010.1 CDS SAR2668 NC_002952.2 2754408 2755274 R Similar to Mus musculus fructosamine-3-kinase FN3K SW:FN3K_MOUSE (Q9ER35) (309 aa) fasta scores: E(): 8.9e-18, 30% id in 310 aa, and to Vibrio cholerae hypothetical protein VC1539 SW:YF39_VIBCH (Q9KRU5) (288 aa) fasta scores: E(): 9.7e-24, 32.63% id in 288 aa; hypothetical protein complement(2754408..2755274) Staphylococcus aureus subsp. aureus MRSA252 2860579 YP_042011.1 CDS SAR2669 NC_002952.2 2755492 2756556 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 2755492..2756556 Staphylococcus aureus subsp. aureus MRSA252 2860580 YP_042012.1 CDS SAR2670 NC_002952.2 2756711 2756986 D hypothetical protein 2756711..2756986 Staphylococcus aureus subsp. aureus MRSA252 2860581 YP_042013.1 CDS SAR2671 NC_002952.2 2757172 2757894 R Similar to Lactococcus lactis hypothetical protein YoaD TR:Q9CFU8 (EMBL:AE006369) (241 aa) fasta scores: E(): 4.7e-67, 67.79% id in 236 aa, and to Streptococcus pyogenes hypothetical protein SPY0233 TR:Q9A1K3 (EMBL:AE006490) (255 aa) fasta scores: E(): 2.2e-59, 59.74% id in 236 aa; hypothetical protein complement(2757172..2757894) Staphylococcus aureus subsp. aureus MRSA252 2860582 YP_042014.1 CDS SAR2672 NC_002952.2 2758250 2758699 D Similar to Lactococcus lactis hypothetical protein YldC TR:Q9CGH3 (EMBL:AE006345) (152 aa) fasta scores: E(): 1.2e-26, 44.96% id in 149 aa, and to Pseudomonas aeruginosa hypothetical protein PA1353 TR:Q9I3Z1 (EMBL:AE004565) (137 aa) fasta scores: E(): 1.5e-05, 26.61% id in 139 aa; hypothetical protein 2758250..2758699 Staphylococcus aureus subsp. aureus MRSA252 2860583 YP_042015.1 CDS SAR2673 NC_002952.2 2758780 2759367 R Similar to Clostridium acetobutylicum TetR family transcriptional regulator CAP0046 TR:Q97TQ2 (EMBL:AE001438) (188 aa) fasta scores: E(): 4e-10, 26.82% id in 164 aa, and to Lactococcus lactis transcriptional regulator YxcB TR:Q9CDI1 (EMBL:AE006453) (204 aa) fasta scores: E(): 2e-09, 23.46% id in 196 aa; DNA-binding protein complement(2758780..2759367) Staphylococcus aureus subsp. aureus MRSA252 2860584 YP_042016.1 CDS SAR2674 NC_002952.2 2759510 2761192 D SLactococcus lactis hypothetical protein YmgC TR:Q9CG75 (EMBL:AE006355) (572 aa) fasta scores: E(): 6.6e-53, 32.67% id in 554 aa. Weakly similar to Rhodococcus sp MB1 cocaine esterase CocE TR:Q9L9D7 (EMBL:AF173165) (574 aa) fasta scores: E(): 8.1e-06, 25.12% id in 613 aa; hypothetical protein 2759510..2761192 Staphylococcus aureus subsp. aureus MRSA252 2860585 YP_042017.1 CDS panD NC_002952.2 2761321 2761704 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(2761321..2761704) Staphylococcus aureus subsp. aureus MRSA252 2861474 YP_042018.1 CDS panC NC_002952.2 2761706 2762557 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(2761706..2762557) Staphylococcus aureus subsp. aureus MRSA252 2861473 YP_042019.1 CDS panB NC_002952.2 2762550 2763368 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(2762550..2763368) Staphylococcus aureus subsp. aureus MRSA252 2861472 YP_042020.1 CDS SAR2678 NC_002952.2 2763441 2764301 D catalyzes the formation of 2-dehydropantoate from (R)-pantoate; 2-dehydropantoate 2-reductase 2763441..2764301 Staphylococcus aureus subsp. aureus MRSA252 2860586 YP_042021.1 CDS SAR2679 NC_002952.2 2764387 2765091 R Similar to Klebsiella terrigena alpha-acetolactate decarboxylase BudA SW:ALDC_KLETE (Q04518) (259 aa) fasta scores: E(): 1.2e-23, 33.47% id in 236 aa, and to Lactococcus lactis alpha-acetolactate decarboxylase AldB TR:P95676 (EMBL:S82499) (236 aa) fasta scores: E(): 5.2e-36, 44.72% id in 237 aa. CDS is truncated at the N-terminus in comparison to the Klebsiella terrigena protein. Similar to SAR2296, 74.359% identity (74.359% ungapped) in 234 aa overlap; alpha-acetolactate decarboxylase complement(2764387..2765091) Staphylococcus aureus subsp. aureus MRSA252 2860587 YP_042022.1 CDS ldh2 NC_002952.2 2765369 2766328 R Similar to Bacillus caldotenax L-lactate dehydrogenase Ldh SW:LDH_BACCA (P10655) (317 aa) fasta scores: E(): 2.7e-60, 54.75% id in 305 aa, and to Bacillus caldolyticus L-lactate dehydrogenase TR:Q59244 (EMBL:M19394) (317 aa) fasta scores: E(): 2.3e-60, 54.87% id in 308 aa. Similar to SAR0234, 59.223% identity (59.609% ungapped) in 309 aa overlap; L-lactate dehydrogenase 2 complement(2765369..2766328) Staphylococcus aureus subsp. aureus MRSA252 2859696 YP_042023.1 CDS SAR2681 NC_002952.2 2767014 2768462 D Similar to Lactococcus lactis cationic amino acid transporter CtrA TR:Q9CJ89 (EMBL:AE006249) (469 aa) fasta scores: E(): 1.9e-111, 64.51% id in 465 aa, and to Xylella fastidiosa cationic amino acid transporter XF2207 TR:Q9PBD7 (EMBL:AE004033) (483 aa) fasta scores: E(): 3.1e-51, 35.72% id in 459 aa; amino acid permease 2767014..2768462 Staphylococcus aureus subsp. aureus MRSA252 2860588 YP_042024.1 CDS SAR2682 NC_002952.2 2768542 2769885 R catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase complement(2768542..2769885) Staphylococcus aureus subsp. aureus MRSA252 2860589 YP_042025.1 CDS SAR2683 NC_002952.2 2770133 2770549 D hypothetical protein 2770133..2770549 Staphylococcus aureus subsp. aureus MRSA252 2860590 YP_042026.1 CDS fda NC_002952.2 2770672 2771562 D catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis; fructose-1,6-bisphosphate aldolase 2770672..2771562 Staphylococcus aureus subsp. aureus MRSA252 2860659 YP_042027.1 CDS mqo2 NC_002952.2 2771755 2773251 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(2771755..2773251) Staphylococcus aureus subsp. aureus MRSA252 2861308 YP_042028.1 CDS SAR2686 NC_002952.2 2773678 2773878 D No significant database matches. Doubtful CDS; hypothetical protein 2773678..2773878 Staphylococcus aureus subsp. aureus MRSA252 2860591 YP_042029.1 CDS SAR2687 NC_002952.2 2773938 2775557 R Similar to Homo sapiens hypothetical protein associated with susceptibility to essential hypertension, SA TR:Q13732 (EMBL:D16350) (578 aa) fasta scores: E(): 3.6e-69, 37.68% id in 544 aa, and to Bacillus subtilis hypothetical protein YtcI TR:O34613 (EMBL:AF008220) (531 aa) fasta scores: E(): 1.8e-122, 57.17% id in 530 aa. CDS is truncated at the N-terminus in comparison to the Homo sapiens protein; AMP-binding protein complement(2773938..2775557) Staphylococcus aureus subsp. aureus MRSA252 2860592 YP_042030.1 CDS SAR2688 NC_002952.2 2775730 2776173 R Poor database matches. Similar to the C-terminal region of Bacillus subtilis hypothetical protein YhgC SW:YHGC_BACSU (P38049) (166 aa) fasta scores: E(): 2.7e-11, 35.53% id in 121 aa; hypothetical protein complement(2775730..2776173) Staphylococcus aureus subsp. aureus MRSA252 2860593 YP_042031.1 CDS SAR2689 NC_002952.2 2776453 2776665 R Poor database matches. Weakly similar to Bacillus subtilis hypothetical protein YozE TR:O31864 (EMBL:Z99114) (74 aa) fasta scores: E(): 7.9, 28.16% id in 71 aa; hypothetical protein complement(2776453..2776665) Staphylococcus aureus subsp. aureus MRSA252 2860594 YP_042032.1 CDS cudB NC_002952.2 2776943 2778652 R catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase complement(2776943..2778652) Staphylococcus aureus subsp. aureus MRSA252 2859253 YP_042033.1 CDS cudA NC_002952.2 2778913 2780403 R Similar to Staphylococcus xylosus glycine betaine aldehyde dehydrogenase CudA TR:Q9X2M1 (EMBL:AF009415) (497 aa) fasta scores: E(): 3.2e-161, 82.05% id in 496 aa, and to Bacillus subtilis betaine aldehyde dehydrogenase GbsA SW:DHAB_BACSU (P71016) (490 aa) fasta scores: E(): 2.2e-129, 66.87% id in 489 aa; betaine aldehyde dehydrogenase complement(2778913..2780403) Staphylococcus aureus subsp. aureus MRSA252 2859252 YP_042034.1 CDS SAR2692 NC_002952.2 2780653 2781219 D Similar to Staphylococcus xylosus regulatory protein CudC TR:Q9X2M0 (EMBL:AF009415) (186 aa) fasta scores: E(): 1.2e-45, 70.33% id in 182 aa, and to Bacillus subtilis hypothetical protein YuaC SW:YUAC_BACSU (P71015) (180 aa) fasta scores: E(): 6.5e-33, 55.35% id in 168 aa; hypothetical protein 2780653..2781219 Staphylococcus aureus subsp. aureus MRSA252 2860595 YP_042035.1 CDS cudT NC_002952.2 2781389 2783011 R Similar to Staphylococcus xylosus choline transporter CudT TR:Q9X2L9 (EMBL:AF009415) (540 aa) fasta scores: E(): 2.8e-171, 77.4% id in 540 aa, and to Corynebacterium glutamicum glycine betaine transporter BetP SW:BETP_CORGL (P54582) (595 aa) fasta scores: E(): 9e-49, 30.63% id in 519 aa. CDS is truncated at the N-terminus in comparison to the Corynebacterium glutamicum protein; choline transporter complement(2781389..2783011) Staphylococcus aureus subsp. aureus MRSA252 2859254 YP_042036.1 CDS nrdG NC_002952.2 2783529 2784065 R Similar to Escherichia coli anaerobic ribonucleoside-triphosphate reductase activating protein NrdG SW:NRDG_ECOLI (P39329) (154 aa) fasta scores: E(): 4.7e-15, 38.46% id in 143 aa, and to Lactococcus lactis anaerobic ribonucleotide reductase activator protein NrdG TR:Q9ZAX5 (EMBL:U73336) (199 aa) fasta scores: E(): 2.9e-26, 46.98% id in 166 aa; anaerobic ribonucleotide reductase activating protein complement(2783529..2784065) Staphylococcus aureus subsp. aureus MRSA252 2859167 YP_042037.1 CDS nrdD NC_002952.2 2784062 2785912 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(2784062..2785912) Staphylococcus aureus subsp. aureus MRSA252 2859166 YP_042038.1 CDS SAR2696 NC_002952.2 2786159 2787529 R Similar to Bacillus subtilis citrate transporter CitN SW:CITN_BACSU (P42308) (426 aa) fasta scores: E(): 5.1e-21, 32.81% id in 448 aa, and to Bacillus halodurans magnesium citrate secondary transporter BH0745 TR:Q9KEV4 (EMBL:AP001509) (442 aa) fasta scores: E(): 2e-83, 50.55% id in 449 aa; transporter protein complement(2786159..2787529) Staphylococcus aureus subsp. aureus MRSA252 2860596 YP_042039.1 CDS SAR2697 NC_002952.2 2788018 2788626 R catalyzes the formation of siroheme from precorrin-2; precorrin-2 dehydrogenase complement(2788018..2788626) Staphylococcus aureus subsp. aureus MRSA252 2860597 YP_042040.1 CDS cysJ NC_002952.2 2788692 2790572 R C-terminus is similar to the C-terminal region of Escherichia coli sulfite reductase [NADPH] flavoprotein alpha-component CysJ SW:CYSJ_ECOLI (P38038) (598 aa) fasta scores: E(): 3.3e-75, 39.41% id in 548 aa. Similar to the full length Bacillus subtilis sulfite reductase [NADPH] flavoprotein alpha-component-like protein YvgR TR:O32214 (EMBL:Z99121) (605 aa) fasta scores: E(): 6.8e-110, 48.08% id in 628 aa; sulfite reductase [NADPH] flavoprotein alpha-component complement(2788692..2790572) Staphylococcus aureus subsp. aureus MRSA252 2859257 YP_042041.1 CDS SAR2699 NC_002952.2 2790963 2791460 R Similar to Citrus sinensis glutathione peroxidase homologue CSA SW:GSHZ_CITSI (Q06652) (167 aa) fasta scores: E(): 2.7e-25, 41.13% id in 158 aa, and to Schizosaccharomyces pombe glutathione peroxidase GPX1 SW:GSHJ_SCHPO (O59858) (158 aa) fasta scores: E(): 6.6e-27, 46.1% id in 154 aa. Similar to SAR1280, 50.323% identity (50.323% ungapped) in 155 aa overlap; glutathione peroxidase complement(2790963..2791460) Staphylococcus aureus subsp. aureus MRSA252 2860598 YP_042042.1 CDS SAR2700 NC_002952.2 2792901 2794901 R Similar to Lactococcus lactis ABC transporter permease and substrate binding protein YsaB TR:Q9CET5 (EMBL:AE006405) (667 aa) fasta scores: E(): 2.2e-23, 22.79% id in 693 aa, and to Bacillus halodurans ABC transporter BH0752 TR:Q9KEU7 (EMBL:AP001509) (642 aa) fasta scores: E(): 5.5e-10, 21.57% id in 672 aa; hypothetical protein complement(2792901..2794901) Staphylococcus aureus subsp. aureus MRSA252 2860599 YP_042043.1 CDS SAR2701 NC_002952.2 2794898 2795653 R Similar to Lactococcus lactis ABC transporter ATP-binding protein YsaC TR:Q9CET4 (EMBL:AE006405) (259 aa) fasta scores: E(): 7e-38, 48% id in 250 aa, and to Bacillus subtilis hypothetical ABC transporter ATP-binding protein YxdL SW:YXDL_BACSU (P42423) (257 aa) fasta scores: E(): 3.9e-37, 49.2% id in 250 aa; ABC transporter ATP-binding protein complement(2794898..2795653) Staphylococcus aureus subsp. aureus MRSA252 2860600 YP_042044.1 CDS SAR2702 NC_002952.2 2795761 2796648 R Two-component regulatory system family, sensor kinase. Similar to Streptococcus pneumoniae histidine kinase SP1632 TR:Q9S1K1 (EMBL:AJ006391) (324 aa) fasta scores: E(): 7e-27, 32.77% id in 299 aa, and to Lactococcus lactis sensor protein kinase KinG TR:Q9CET8 (EMBL:AE006404) (291 aa) fasta scores: E(): 1.3e-24, 31.61% id in 291 aa; sensor kinase complement(2795761..2796648) Staphylococcus aureus subsp. aureus MRSA252 2860601 YP_042045.1 CDS SAR2703 NC_002952.2 2796659 2797324 R Two-component regulatory system family, response regulator protein. Similar to Streptococcus thermophilus response regulator Rr1 TR:Q9AGS2 (EMBL:AF327738) (226 aa) fasta scores: E(): 2.5e-42, 51.83% id in 218 aa, and to Streptococcus pneumoniae response regulator SP1633 TR:Q9S1K2 (EMBL:AJ006391) (225 aa) fasta scores: E(): 1.6e-39, 48.62% id in 218 aa; response regulator protein complement(2796659..2797324) Staphylococcus aureus subsp. aureus MRSA252 2860602 YP_042046.1 CDS SAR2704 NC_002952.2 2797350 2797550 R hypothetical protein complement(2797350..2797550) Staphylococcus aureus subsp. aureus MRSA252 2860603 YP_042047.1 CDS SAR2705 NC_002952.2 2797873 2798820 D Identical to Staphylococcus aureus transposase TR:O87114 (EMBL:AB010124) (328 aa) fasta scores: E(): 2.8e-127, 100.000% id in 315 aa, and similar to Bacillus halodurans transposase BH3503 TR:Q9JWR3 (EMBL:AP001520) (314 aa) fasta scores: E(): 3e-71, 58.413% id in 315 aa; transposase 2797873..2798820 Staphylococcus aureus subsp. aureus MRSA252 2860732 YP_042048.1 CDS SAR2706a NC_002952.2 2800306 2800407 R Doubtful CDS; hypothetical protein complement(2800306..2800407) Staphylococcus aureus subsp. aureus MRSA252 2860733 YP_042049.1 CDS SAR2707 NC_002952.2 2800529 2800984 R Similar to Lactococcus lactis transcriptional regulator RmaF TR:Q9CG06 (EMBL:AE006362) (156 aa) fasta scores: E(): 1.7e-13, 37.68% id in 138 aa. Weakly similar to Escherichia coli haemolysin transcriptional regulator SlyA SW:SLYA_ECOLI (P55740) (146 aa) fasta scores: E(): 0.33, 26.61% id in 124 aa; regulatory protein complement(2800529..2800984) Staphylococcus aureus subsp. aureus MRSA252 2860734 YP_042050.1 CDS SAR2708 NC_002952.2 2801229 2801990 R Similar to Lactococcus lactis tributyrin esterase EstA TR:Q9L9W2 (EMBL:AF157601) (258 aa) fasta scores: E(): 1.1e-27, 36.36% id in 253 aa, and to Streptococcus pyogenes tributyrin esterase SPY1022 TR:Q99ZY1 (EMBL:AE006547) (261 aa) fasta scores: E(): 1.7e-22, 30.58% id in 255 aa; esterase complement(2801229..2801990) Staphylococcus aureus subsp. aureus MRSA252 2860735 YP_042051.1 CDS clfB NC_002952.2 2802106 2804727 R Similar to Staphylococcus aureus clumping factor B precursor ClfB TR:O86476 (EMBL:AJ224764) (913 aa) fasta scores: E(): 4.6e-184, 89.48% id in 913 aa, and to Staphylococcus epidermidis fibrinogen-binding protein precursor TR:O70022 (EMBL:Y17116) (1092 aa) fasta scores: E(): 4.8e-44, 36.53% id in 1103 aa. CDS contains imperfect dipetide repeat (DS x321) between residues 587 and 800. In comparison to the ClfB protein, the CDS contains extra copies of the DS repeat. Probable LPXTG-sorted surface protein; fibrinogen and keratin-10 binding surface anchored protein complement(2802106..2804727) Staphylococcus aureus subsp. aureus MRSA252 2859232 YP_042052.1 CDS SAR2710 NC_002952.2 2805077 2805781 R Similar to Anabaena sp global nitrogen regulator NtcA SW:NTCA_ANASP (Q05061) (223 aa) fasta scores: E(): 0.0051, 18.94% id in 190 aa, and to Bacillus licheniformis Crp/Fnr family protein ArcR TR:Q9K5F3 (EMBL:Y17554) (225 aa) fasta scores: E(): 2.2e-10, 21.91% id in 219 aa; regulatory protein complement(2805077..2805781) Staphylococcus aureus subsp. aureus MRSA252 2860736 YP_042053.2 CDS arcC NC_002952.2 2805880 2806821 R catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase complement(2805880..2806821) Staphylococcus aureus subsp. aureus MRSA252 2859850 YP_042054.1 CDS arcD NC_002952.2 2806838 2808274 R Similar to Pseudomonas aeruginosa arginine/ornithine antiporter ArcD SW:ARCD_PSEAE (P18275) (482 aa) fasta scores: E(): 7.8e-77, 46.2% id in 487 aa, and to Bacillus licheniformis permease ArcD TR:O86133 (EMBL:Y17554) (468 aa) fasta scores: E(): 1.2e-99, 59.23% id in 471 aa; arginine/ornithine antiporter complement(2806838..2808274) Staphylococcus aureus subsp. aureus MRSA252 2859851 YP_042055.1 CDS arcB NC_002952.2 2808359 2809369 R catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase complement(2808359..2809369) Staphylococcus aureus subsp. aureus MRSA252 2859849 YP_042056.1 CDS arcA NC_002952.2 2809402 2810637 R catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase complement(2809402..2810637) Staphylococcus aureus subsp. aureus MRSA252 2859848 YP_042057.1 CDS SAR2715 NC_002952.2 2810984 2811433 R Similar to Bacillus stearothermophilus regulator of arginine biosynthesis genes, arginine repressor ArgR SW:ARGR_BACST (O31408) (149 aa) fasta scores: E(): 1.3e-06, 25% id in 148 aa, and to Thermotoga maritima arginine repressor TM0371 SW:ARGR_THEMA (Q9WW19) (152 aa) fasta scores: E(): 1.1e-10, 30.46% id in 151 aa; arginine repressor family protein complement(2810984..2811433) Staphylococcus aureus subsp. aureus MRSA252 2860737 YP_042058.1 CDS aur NC_002952.2 2811800 2813329 R Previously sequenced as Staphylococcus aureus zinc metalloproteinase aureolysin precursor Aur SW:AURE_STAAU (P81177) (509 aa) fasta scores: E(): 7.1e-185, 99.8% id in 509 aa. Similar to Staphylococcus epidermidis extracellular elastase precursor SepA SW:SEPA_STAEP (P43148) (507 aa) fasta scores: E(): 2.3e-136, 72.29% id in 509 aa; zinc metalloproteinase aureolysin complement(2811800..2813329) Staphylococcus aureus subsp. aureus MRSA252 2859883 YP_042059.1 CDS isaB NC_002952.2 2813743 2814270 R Poor database matches. Similar to Staphylococcus aureus immunodominant antigen B IsaB TR:Q9LAB5 (EMBL:AF144682) (175 aa) fasta scores: E(): 2.3e-53, 82.85% id in 175 aa; immunodominant antigen B complement(2813743..2814270) Staphylococcus aureus subsp. aureus MRSA252 2859672 YP_042060.1 CDS SAR2718 NC_002952.2 2814526 2814999 D hypothetical protein 2814526..2814999 Staphylococcus aureus subsp. aureus MRSA252 2860738 YP_042061.1 CDS SAR2719 NC_002952.2 2815239 2817113 D Similar to Bacillus subtilis cel operon regulator CelR SW:CELR_BACSU (P46321) (641 aa) fasta scores: E(): 1e-14, 21.6% id in 648 aa, and to Streptococcus pyogenes hypothetical protein SPY1952 TR:Q99XZ1 (EMBL:AE006618) (686 aa) fasta scores: E(): 1.1e-09, 22.78% id in 689 aa; transcriptional regulator 2815239..2817113 Staphylococcus aureus subsp. aureus MRSA252 2860739 YP_042062.1 CDS SAR2720 NC_002952.2 2817190 2819142 D N-terminus is similar to the N-terminal region of Escherichia coli PTS system, fructose-like-1 IIBC component FrvB SW:PTVB_ECOLI (P32154) (483 aa) fasta scores: E(): 7.3e-48, 35.18% id in 469 aa, and to the C-terminal region of Xanthomonas campestris PTS system, fructose-specific IIBC component fruA SW:PTFB_XANCP (P23355) (580 aa) fasta scores: E(): 5.6e-65, 43.93% id in 478 aa; PTS transport system, IIABC component 2817190..2819142 Staphylococcus aureus subsp. aureus MRSA252 2860740 YP_042063.1 CDS pmi NC_002952.2 2819156 2820094 D Similar to Streptococcus mutans mannose-6-phosphate isomerase Pmi SW:MANA_STRMU (Q59935) (316 aa) fasta scores: E(): 2.4e-64, 53.72% id in 309 aa, and to Lactococcus lactis mannose-6-phosphate isomerase Pmi TR:Q9CHG2 (EMBL:AE006310) (315 aa) fasta scores: E(): 1.1e-67, 52.58% id in 310 aa; mannose-6-phosphate isomerase 2819156..2820094 Staphylococcus aureus subsp. aureus MRSA252 2859909 YP_042064.1 CDS SAR2722 NC_002952.2 2820206 2823187 R Similar to Lactococcus lactis phage infection protein pip SW:PIP_LACLA (P49022) (901 aa) fasta scores: E(): 3.3e-34, 28.14% id in 995 aa, and to Bacillus subtilis hypothetical protein YhgE SW:YHGE_BACSU (P32399) (775 aa) fasta scores: E(): 9e-19, 22.61% id in 964 aa; hypothetical protein complement(2820206..2823187) Staphylococcus aureus subsp. aureus MRSA252 2860741 YP_042065.1 CDS SAR2723 NC_002952.2 2823398 2825257 D No significant database matches to the full length CDS. C-terminal region is similar to Lactococcus lactis N-acetylmuramidase AcmB TR:Q9CED5 (EMBL:AE006420) (475 aa) fasta scores: E(): 7.4e-29, 33.4% id in 482 aa, and to Streptococcus pyogenes immunogenic secreted protein precursor Isp TR:Q54707 (EMBL:U31811) (534 aa) fasta scores: E(): 1.2e-13, 26.7% id in 543 aa; N-acetylmuramoyl-L-alanine amidase 2823398..2825257 Staphylococcus aureus subsp. aureus MRSA252 2860742 YP_042066.1 CDS SAR2724 NC_002952.2 2825522 2826082 R Similar to an internal region of Escherichia coli isochorismatase EntB SW:ENTB_ECOLI (P15048) (285 aa) fasta scores: E(): 8.9e-08, 27.84% id in 176 aa, and to the full length Thermoplasma acidophilum N-carbamoylsarcosine amidase related protein TA1053 TR:Q9HJB7 (EMBL:AL445066) (192 aa) fasta scores: E(): 3e-08, 23.83% id in 193 aa; isochorismatase complement(2825522..2826082) Staphylococcus aureus subsp. aureus MRSA252 2860743 YP_042067.1 CDS sasF NC_002952.2 2826250 2828133 R Poor database matches. Similar to Mycoplasma hominis Lmp1 TR:Q49525 (EMBL:U21962) (1365 aa) fasta scores: E(): 0.0062, 21.78% id in 606 aa. Possible LPXAG-sorted surface protein; surface anchored protein complement(2826250..2828133) Staphylococcus aureus subsp. aureus MRSA252 2859122 YP_042068.1 CDS SAR2726 NC_002952.2 2828375 2829733 R Poor database matches. Similar to Streptococcus cristatus hypothetical protein TR:Q9KX32 (EMBL:U96166) (442 aa) fasta scores: E(): 1.3e-54, 38.83% id in 448 aa; hypothetical protein complement(2828375..2829733) Staphylococcus aureus subsp. aureus MRSA252 2860744 YP_042069.1 CDS SAR2727 NC_002952.2 2829726 2831234 R Weakly similar to Lactococcus lactis lipopolysaccharide biosynthesis protein YohH TR:Q9CFL5 (EMBL:AE006375) (541 aa) fasta scores: E(): 2.9e-17, 24.01% id in 533 aa. C-terminal region is similar to Homo sapiens N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein PIGA SW:PIGA_HUMAN (P37287) (484 aa) fasta scores: E(): 2.2e-06, 20.44% id in 406 aa; hypothetical protein complement(2829726..2831234) Staphylococcus aureus subsp. aureus MRSA252 2860745 YP_042070.1 CDS SAR2728 NC_002952.2 2831252 2833642 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins; preprotein translocase subunit SecA complement(2831252..2833642) Staphylococcus aureus subsp. aureus MRSA252 2860746 YP_042071.1 CDS SAR2729 NC_002952.2 2833632 2834591 R Poor database matches. N-terminal region is similar to Streptococcus gordonii hypothetical protein TR:Q9AET7 (EMBL:AY028381) (159 aa) fasta scores: E(): 7.7e-15, 37.12% id in 132 aa; hypothetical protein complement(2833632..2834591) Staphylococcus aureus subsp. aureus MRSA252 2860747 YP_042072.1 CDS SAR2730 NC_002952.2 2834569 2836137 R Poor database matches. Similar to Streptococcus gordonii hypothetical protein TR:Q9AET8 (EMBL:AY028381) (510 aa) fasta scores: E(): 2.7e-76, 39.02% id in 515 aa; hypothetical protein complement(2834569..2836137) Staphylococcus aureus subsp. aureus MRSA252 2860748 YP_042073.1 CDS secY NC_002952.2 2837691 2838902 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(2837691..2838902) Staphylococcus aureus subsp. aureus MRSA252 2860750 YP_042074.1 CDS sasA NC_002952.2 2839031 2843086 R Similar to the N-terminal region of Streptococcus gordonii streptococcal hemagglutinin Hsa TR:Q9KWR3 (EMBL:AB029393) (2178 aa) fasta scores: E(): 1.2e-52, 33.82% id in 1369 aa, and the C-terminal of Staphylococcus epidermidis cell-surface adhesin SdrF TR:Q9KI14 (EMBL:AF245041) (1733 aa) fasta scores: E(): 9.2e-35, 32.35% id in 1332 aa. CDS contains a serine rich region, residues 752 to 1287. Probable LPXTG-sorted surface protein; serine-rich repeat-containing protein complement(2839031..2843086) Staphylococcus aureus subsp. aureus MRSA252 2859119 YP_042075.1 CDS SAR2735 NC_002952.2 2843633 2844325 R Similar to Rhizobium loti hypothetical protein MLL0910 TR:BAB48397 (EMBL:AP002996) (202 aa) fasta scores: E(): 4.7e-24, 40.84% id in 213 aa, and to Aquifex aeolicus hypothetical protein AQ_928 TR:O67071 (EMBL:AE000714) (196 aa) fasta scores: E(): 3e-18, 36.78% id in 174 aa; hypothetical protein complement(2843633..2844325) Staphylococcus aureus subsp. aureus MRSA252 2860751 YP_042076.1 CDS SAR2738 NC_002952.2 2845569 2845871 D hypothetical protein 2845569..2845871 Staphylococcus aureus subsp. aureus MRSA252 2860753 YP_042077.1 CDS SAR2739 NC_002952.2 2846021 2846380 D No significant database matches. N-terminal region is similar to Staphylococcus carnosus N5,N10-methylenetetrahydromethanopterin reductase homologue SceB TR:O54485 (EMBL:U96107) (61 aa) fasta scores: E(): 3.2e-06, 50% id in 58 aa; hypothetical protein 2846021..2846380 Staphylococcus aureus subsp. aureus MRSA252 2860754 YP_042078.1 CDS SAR2740 NC_002952.2 2846465 2847076 R Similar to Bacillus subtilis hypothetical protein YwrF TR:O05220 (EMBL:Z93767) (205 aa) fasta scores: E(): 1.4e-36, 50% id in 204 aa, and to Bacillus halodurans hypothetical protein BH2278 TR:Q9KAK9 (EMBL:AP001515) (209 aa) fasta scores: E(): 3.7e-30, 42.78% id in 201 aa; hypothetical protein complement(2846465..2847076) Staphylococcus aureus subsp. aureus MRSA252 2860755 YP_042079.1 CDS SAR2741 NC_002952.2 2847155 2847631 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; a fusion protein of this enzyme with MsrB provides protection against oxidative stress in Neisseria gonorrhoeae; methionine sulfoxide reductase A complement(2847155..2847631) Staphylococcus aureus subsp. aureus MRSA252 2860756 YP_042080.1 CDS SAR2742 NC_002952.2 2847634 2848134 R Similar to Lactococcus lactis hypothetical protein YveC TR:Q9CDZ4 (EMBL:AE006436) (164 aa) fasta scores: E(): 1.3e-22, 43.22% id in 155 aa. Weak similarity to Saccharomyces cerevisiae glucosamine-phosphate N-acetyltransferase GNA1 SW:GNA1_YEAST (P43577) (159 aa) fasta scores: E(): 0.03, 26.49% id in 151 aa; acetyltransferase (GNAT) family protein complement(2847634..2848134) Staphylococcus aureus subsp. aureus MRSA252 2860757 YP_042081.1 CDS SAR2743 NC_002952.2 2848369 2849136 R Similar to Staphylococcus aureus type 1 capsule synthesis protein CapC SW:CAPC_STAAU (P39852) (255 aa) fasta scores: E(): 6.5e-57, 56.47% id in 255 aa, and to Staphylococcus aureus type 5 capsule synthesis protein Cap5C TR:P95697 (EMBL:U81973) (254 aa) fasta scores: E(): 3.2e-51, 53.33% id in 255 aa, and to Staphylococcus aureus type 8 capsule synthesis protein Cap8C TR:P72369 (EMBL:U73374) (254 aa) fasta scores: E(): 3.7e-51, 53.33% id in 255 aa. Similar to SAR0153, 52.549% identity (53.175% ungapped) in 255 aa overlap; capsule synthesis protein complement(2848369..2849136) Staphylococcus aureus subsp. aureus MRSA252 2860758 YP_042082.1 CDS SAR2744 NC_002952.2 2849133 2849825 R Similar to Staphylococcus aureus type 1 capsule synthesis protein CapB SW:CAPB_STAAU (P39851) (228 aa) fasta scores: E(): 5.1e-51, 60.08% id in 228 aa, and to Staphylococcus aureus type 5 capsule synthesis protein Cap5B TR:P95696 (EMBL:U81973) (228 aa) fasta scores: E(): 2.2e-48, 58.07% id in 229 aa, and to Staphylococcus aureus type 8 capsule synthesis protein Cap8B TR:P72368 (EMBL:U73374) (228 aa) fasta scores: E(): 1.8e-47, 57.2% id in 229 aa. Similar to SAR0152, 55.895% identity (56.140% ungapped) in 229 aa overlap; capsule synthesis protein complement(2849133..2849825) Staphylococcus aureus subsp. aureus MRSA252 2860759 YP_042083.1 CDS SAR2745 NC_002952.2 2849842 2850504 R Similar to Staphylococcus aureus type 1 capsule synthesis protein CapA SW:CAPA_STAAU (P39850) (221 aa) fasta scores: E(): 3e-39, 53.18% id in 220 aa, and to Staphylococcus aureus type 5 capsule synthesis protein Cap5A TR:P95695 (EMBL:U81973) (222 aa) fasta scores: E(): 3.5e-38, 52.48% id in 221 aa, and to Staphylococcus aureus type 8 capsule synthesis protein Cap8A TR:P72367 (EMBL:U73374) (222 aa) fasta scores: E(): 5.3e-38, 52.03% id in 221 aa. Similar to SAR0151, 52.489% identity (52.727% ungapped) in 221 aa overlap; capsule synthesis protein complement(2849842..2850504) Staphylococcus aureus subsp. aureus MRSA252 2860760 YP_042084.1 CDS icaR NC_002952.2 2851350 2851910 R Previously sequenced as Staphylococcus aureus intercellular adhesion (ica) operon transcriptional regulator IcaR TR:Q9RQQ0 (EMBL:AF086783) (186 aa) fasta scores: E(): 1.1e-64, 99.46% id in 186 aa. Similar to Staphylococcus caprae ica operon transcriptional regulator IcaR TR:Q9AIQ9 (EMBL:AF246926) (190 aa) fasta scores: E(): 2.5e-44, 67.02% id in 185 aa; ica operon transcriptional regulator complement(2851350..2851910) Staphylococcus aureus subsp. aureus MRSA252 2859659 YP_042085.1 CDS icaA NC_002952.2 2852074 2853312 D predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 2852074..2853312 Staphylococcus aureus subsp. aureus MRSA252 2859655 YP_042086.1 CDS icaD NC_002952.2 2853276 2853581 D Previously sequenced as Staphylococcus aureus intercellular adhesion protein D IcaD TR:Q9RQP8 (EMBL:AF086783) (101 aa) fasta scores: E(): 5.7e-38, 98.02% id in 101 aa. Similar to Staphylococcus caprae intercellular adhesion protein D IcaD TR:Q9AIQ7 (EMBL:AF246926) (101 aa) fasta scores: E(): 2.8e-25, 65.34% id in 101 aa; intercellular adhesion protein D 2853276..2853581 Staphylococcus aureus subsp. aureus MRSA252 2859658 YP_042087.1 CDS icaB NC_002952.2 2853578 2854450 D Previously sequenced as Staphylococcus aureus intercellular adhesion protein B IcaB TR:Q9RQP7 (EMBL:AF086783) (290 aa) fasta scores: E(): 9.7e-109, 97.58% id in 290 aa. Similar to Staphylococcus caprae intercellular adhesion protein B IcaB TR:Q9AIQ6 (EMBL:AF246926) (289 aa) fasta scores: E(): 3.7e-73, 65.39% id in 289 aa; intercellular adhesion protein B 2853578..2854450 Staphylococcus aureus subsp. aureus MRSA252 2859656 YP_042088.1 CDS icaC NC_002952.2 2854437 2855489 D Previously sequenced as Staphylococcus aureus intercellular adhesion protein C IcaC TR:Q9RQP6 (EMBL:AF086783) (350 aa) fasta scores: E(): 1.4e-121, 99.14% id in 350 aa. Similar to Staphylococcus caprae intercellular adhesion protein C IcaC TR:Q9AIQ5 (EMBL:AF246927) (357 aa) fasta scores: E(): 3.5e-100, 78.28% id in 350 aa; intercellular adhesion protein C 2854437..2855489 Staphylococcus aureus subsp. aureus MRSA252 2859657 YP_042089.1 CDS SAR2752 NC_002952.2 2855632 2855799 D No significant database matches. Doubtful CDS; hypothetical protein 2855632..2855799 Staphylococcus aureus subsp. aureus MRSA252 2860761 YP_042090.1 CDS lip NC_002952.2 2855881 2857926 R Similar to Staphylococcus epidermidis lipase precursor GehC SW:LIP_STAEP (Q02510) (688 aa) fasta scores: E(): 5.1e-123, 60.91% id in 701 aa. Previously sequenced as Staphylococcus aureus glycerol ester hydrolase lip TR:Q59811 (EMBL:M90693) (682 aa) fasta scores: E(): 0, 97.5% id in 682 aa; lipase precursor complement(2855881..2857926) Staphylococcus aureus subsp. aureus MRSA252 2859804 YP_042091.1 CDS hisIE NC_002952.2 2859014 2859646 R catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP complement(2859014..2859646) Staphylococcus aureus subsp. aureus MRSA252 2860714 YP_042092.1 CDS hisF NC_002952.2 2859643 2860401 R catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF complement(2859643..2860401) Staphylococcus aureus subsp. aureus MRSA252 2860711 YP_042093.1 CDS hisA NC_002952.2 2860398 2861102 R catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase complement(2860398..2861102) Staphylococcus aureus subsp. aureus MRSA252 2860708 YP_042094.1 CDS hisH NC_002952.2 2861095 2861673 R with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH complement(2861095..2861673) Staphylococcus aureus subsp. aureus MRSA252 2860713 YP_042095.1 CDS hisB NC_002952.2 2861670 2862248 R catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase complement(2861670..2862248) Staphylococcus aureus subsp. aureus MRSA252 2860709 YP_042096.1 CDS SAR2759 NC_002952.2 2862217 2863230 R Similar to Escherichia coli histidinol-phosphate aminotransferase HisC SW:HIS8_ECOLI (P06986) (356 aa) fasta scores: E(): 3.2e-16, 27% id in 337 aa, and to Deinococcus radiodurans histidinol-phosphate aminotransferase DR2461 TR:Q9RRM7 (EMBL:AE002075) (361 aa) fasta scores: E(): 1.4e-18, 28.03% id in 321 aa. CDS is truncated at the N-terminus in comparison to orthologues; aminotransferase complement(2862217..2863230) Staphylococcus aureus subsp. aureus MRSA252 2860762 YP_042097.1 CDS hisD NC_002952.2 2863246 2864502 R catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase complement(2863246..2864502) Staphylococcus aureus subsp. aureus MRSA252 2860710 YP_042098.1 CDS hisG NC_002952.2 2864489 2865103 R short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ; ATP phosphoribosyltransferase catalytic subunit complement(2864489..2865103) Staphylococcus aureus subsp. aureus MRSA252 2860712 YP_042099.1 CDS hisZ NC_002952.2 2865121 2865939 R May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine; ATP phosphoribosyltransferase regulatory subunit complement(2865121..2865939) Staphylococcus aureus subsp. aureus MRSA252 2860763 YP_042100.1 CDS SAR2763 NC_002952.2 2866243 2867367 R hypothetical protein complement(2866243..2867367) Staphylococcus aureus subsp. aureus MRSA252 2860764 YP_042101.1 CDS SAR2764 NC_002952.2 2867485 2867982 R Similar to Bacillus halodurans hypothetical protein BH1868 TR:Q9KBQ7 (EMBL:AP001513) (163 aa) fasta scores: E(): 0.004, 24.67% id in 154 aa, and to Streptomyces coelicolor acetyltransferase SCJ9A.01 TR:Q9S1R9 (EMBL:AL109972) (177 aa) fasta scores: E(): 0.005, 26.71% id in 146 aa; hypothetical protein complement(2867485..2867982) Staphylococcus aureus subsp. aureus MRSA252 2860765 YP_042102.1 CDS SAR2765 NC_002952.2 2868029 2868862 R Similar to Lactococcus lactis ABC transporter permease YdcF TR:Q9CIN0 (EMBL:AE006269) (273 aa) fasta scores: E(): 3.5e-56, 55.07% id in 276 aa, and to Mycoplasma pulmonis ABC transporter permease MYPU_3880 TR:CAC13561 (EMBL:AL445564) (296 aa) fasta scores: E(): 4.3e-12, 26.76% id in 284 aa; ABC transporter permease complement(2868029..2868862) Staphylococcus aureus subsp. aureus MRSA252 2860766 YP_042103.1 CDS SAR2766 NC_002952.2 2868859 2870571 R Similar to Lactococcus lactis ABC transporter ATP binding protein YdcE TR:Q9CIN1 (EMBL:AE006269) (565 aa) fasta scores: E(): 1.9e-93, 47.79% id in 567 aa, and to Pyrococcus horikoshii 284aa long hypothetical cobalt transport ATP-binding protein PH1815 TR:O59479 (EMBL:AP000007) (284 aa) fasta scores: E(): 9.5e-24, 34.95% id in 246 aa; ABC transporter ATP-binding protein complement(2868859..2870571) Staphylococcus aureus subsp. aureus MRSA252 2860767 YP_042104.1 CDS SAR2767 NC_002952.2 2870624 2871178 R Similar to Lactococcus lactis hypothetical protein YdcD TR:Q9CIN2 (EMBL:AE006269) (182 aa) fasta scores: E(): 8.5e-34, 51.64% id in 182 aa, and to Streptococcus pyogenes hypothetical protein SPY1899 TR:Q99Y30 (EMBL:AE006614) (156 aa) fasta scores: E(): 0.23, 28.97% id in 107 aa; hypothetical protein complement(2870624..2871178) Staphylococcus aureus subsp. aureus MRSA252 2860768 YP_042105.1 CDS SAR2768 NC_002952.2 2871207 2872055 R Similar to Helicobacter pylori conserved hypothetical protein HP0709 TR:O25413 (EMBL:AE000584) (300 aa) fasta scores: E(): 2.1e-53, 50.54% id in 277 aa, and to Methanococcus jannaschii hypothetical protein MJ1651 SW:YG51_METJA (Q59045) (263 aa) fasta scores: E(): 4.3e-17, 30.51% id in 272 aa; hypothetical protein complement(2871207..2872055) Staphylococcus aureus subsp. aureus MRSA252 2860769 YP_042106.1 CDS SAR2769 NC_002952.2 2872437 2872952 D Similar to Thermoplasma volcanium hypothetical protein TVG0219791 TR:BAB59353 (EMBL:AP000991) (177 aa) fasta scores: E(): 1.8e-20, 40% id in 170 aa, and to Thermoplasma acidophilum hypothetical protein TA0132 TR:Q9HLU3 (EMBL:AL445063) (180 aa) fasta scores: E(): 4.7e-19, 40.6% id in 165 aa; hypothetical protein 2872437..2872952 Staphylococcus aureus subsp. aureus MRSA252 2860770 YP_042107.1 CDS drp35 NC_002952.2 2873098 2874072 R Highly similar to Staphylococcus aureus beta-lactam induced protein Drp35 TR:Q9S0S3 (EMBL:AB030228) (323 aa) fasta scores: E(): 1.5e-130, 96.59% id in 323 aa. Similar to Xylella fastidiosa hypothetical protein XF1742 TR:Q9PCN6 (EMBL:AE003997) (356 aa) fasta scores: E(): 2.6e-50, 46.45% id in 310 aa. CDS is truncated at the N-terminus in comparison to Xylella fastidiosa protein; hypothetical protein complement(2873098..2874072) Staphylococcus aureus subsp. aureus MRSA252 2859608 YP_042108.1 CDS SAR2771 NC_002952.2 2874313 2875269 D Similar to Lactococcus lactis hypothetical protein YmdE TR:Q9CG88 (EMBL:U92974) (319 aa) fasta scores: E(): 3.9e-86, 67.42% id in 307 aa, and to Bacillus subtilis hypothetical protein YbfQ TR:O31457 (EMBL:AB006424) (322 aa) fasta scores: E(): 1.5e-83, 62.65% id in 316 aa; hypothetical protein 2874313..2875269 Staphylococcus aureus subsp. aureus MRSA252 2860771 YP_042109.1 CDS pcp NC_002952.2 2875422 2876060 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 2875422..2876060 Staphylococcus aureus subsp. aureus MRSA252 2861482 YP_042110.1 CDS SAR2773 NC_002952.2 2876163 2876627 D Poor database matches. Similar to Bacillus halodurans hypothetical protein BH0999 TR:Q9KE59 (EMBL:AP001510) (155 aa) fasta scores: E(): 0.031, 21.62% id in 148 aa; hypothetical protein 2876163..2876627 Staphylococcus aureus subsp. aureus MRSA252 2860772 YP_042111.1 CDS cna NC_002952.2 2876788 2880339 R Previously sequenced as Staphylococcus aureus collagen adhesin precursor Cna SW:CNA_STAAU (Q53654) (1183 aa) fasta scores: E(): 0, 97.97% id in 1183 aa. N-terminal region is similar to Enterococcus faecalis collagen adhesin precursor Ace TR:Q9F866 (EMBL:AF260873) (721 aa) fasta scores: E(): 1.8e-14, 25.78% id in 698 aa. CDS contains a repeat region (187 amino acids x3), residues 533 to 1094. Probable LPXTG-sorted surface protein; collagen adhesin precursor complement(2876788..2880339) Staphylococcus aureus subsp. aureus MRSA252 2859239 YP_042112.1 CDS SAR2775 NC_002952.2 2880717 2882135 D Similar to the C-terminal region of Spinacia oleracea 2-oxoglutarate/malate translocator, chloroplast precursor SODiT1 SW:SOT1_SPIOL (Q41364) (569 aa) fasta scores: E(): 4.1e-81, 46.03% id in 467 aa, and to the full length Bacillus subtilis hypothetical protein YflS TR:O34726 (EMBL:Z99108) (478 aa) fasta scores: E(): 3.4e-100, 54.77% id in 471 aa; sodium:sulfate symporter family protein 2880717..2882135 Staphylococcus aureus subsp. aureus MRSA252 2860773 YP_042113.1 CDS SAR2776 NC_002952.2 2882684 2883592 R Similar to Bacillus halodurans hypothetical protein BH3866 TR:Q9K666 (EMBL:AP001520) (308 aa) fasta scores: E(): 1.1e-46, 46.4% id in 306 aa, and to Vibrio cholerae RarD protein VC0195 TR:Q9KVF1 (EMBL:AE004110) (302 aa) fasta scores: E(): 6.2e-38, 39.78% id in 284 aa; hypothetical protein complement(2882684..2883592) Staphylococcus aureus subsp. aureus MRSA252 2860774 YP_042114.1 CDS SAR2777 NC_002952.2 2883814 2884389 D Poor database matches. Weakly similar to the C-terminal region of Mycobacterium tuberculosis RNA polymerase sigma factor sigg or rv0182c or mtci28.22C TR:O07426 (EMBL:Z97050) (370 aa) fasta scores: E(): 4, 24.71% id in 178 aa; hypothetical protein 2883814..2884389 Staphylococcus aureus subsp. aureus MRSA252 2860775 YP_042115.1 CDS SAR2778 NC_002952.2 2884553 2885569 D Similar to Alcaligenes eutrophus high-affinity nickel transport protein HoxN SW:HOXN_ALCEU (P23516) (351 aa) fasta scores: E(): 4e-52, 44.2% id in 328 aa, and to Helicobacter pylori J99 high-affinity nickel-transport protein JHP0348 SW:NIXA_HELPJ (Q9ZM74) (331 aa) fasta scores: E(): 1.5e-63, 53.15% id in 333 aa; nickel transport protein 2884553..2885569 Staphylococcus aureus subsp. aureus MRSA252 2860776 YP_042116.1 CDS SAR2779 NC_002952.2 2885811 2886611 D Similar to Salmonella typhimurium N-hydroxyarylamine O-acetyltransferase NhoA SW:NHOA_SALTY (Q00267) (281 aa) fasta scores: E(): 1.2e-13, 27.38% id in 241 aa, and to Caulobacter crescentus N-hydroxyarylamine O-acetyltransferase CC1563 TR:Q9A803 (EMBL:AE005831) (275 aa) fasta scores: E(): 1.4e-13, 30.64% id in 248 aa; N-acetyltransferase 2885811..2886611 Staphylococcus aureus subsp. aureus MRSA252 2859038 YP_042117.1 CDS SAR2780 NC_002952.2 2886913 2887425 R Similar to Pseudomonas aeruginosa hypothetical protein PA5409 TR:Q9HTF5 (EMBL:AE004953) (186 aa) fasta scores: E(): 0.0044, 22.48% id in 169 aa, and to Methanothermobacter thermautotrophicus hypothetical protein MTH881 TR:O26967 (EMBL:AE000864) (168 aa) fasta scores: E(): 0.05, 25.15% id in 159 aa; hypothetical protein complement(2886913..2887425) Staphylococcus aureus subsp. aureus MRSA252 2859039 YP_042118.1 CDS vraD NC_002952.2 2887715 2888473 D Previously sequenced as Staphylococcus aureus ABC transporter ATP-binding protein, up-regulated in vancomycin-resistant strains, VraD TR:Q9RL74 (EMBL:Y18641) (252 aa) fasta scores: E(): 4e-80, 99.6% id in 252 aa. Similar to Bacillus halodurans ABC transporter BH3913 TR:Q9K619 (EMBL:AP001520) (253 aa) fasta scores: E(): 1.1e-48, 59.92% id in 252 aa. Similar to SAR0671, 63.200% identity (63.454% ungapped) in 250 aa overlap; ABC transporter ATP-binding protein 2887715..2888473 Staphylococcus aureus subsp. aureus MRSA252 2860428 YP_042119.1 CDS vraE NC_002952.2 2888463 2890343 D Previously sequenced as Staphylococcus aureus ABC transporter permease, up-regulated in vancomycin-resistant strains, VraE TR:Q9KWJ6 (EMBL:AB035452) (626 aa) fasta scores: E(): 3.1e-195, 95.36% id in 626 aa. Similar to Bacillus subtilis YtsD TR:O34741 (EMBL:AF008220) (646 aa) fasta scores: E(): 9.7e-40, 31.89% id in 649 aa; ABC transporter permease 2888463..2890343 Staphylococcus aureus subsp. aureus MRSA252 2860429 YP_042120.1 CDS SAR2783 NC_002952.2 2890435 2890626 D No significant database matches. Doubtful CDS; hypothetical protein 2890435..2890626 Staphylococcus aureus subsp. aureus MRSA252 2859040 YP_042121.1 CDS SAR2787 NC_002952.2 2891713 2892210 R hypothetical protein complement(2891713..2892210) Staphylococcus aureus subsp. aureus MRSA252 2859042 YP_042122.1 CDS SAR2788 NC_002952.2 2892212 2892961 R No significant database matches to the full length CDS. C-terminus is similar to the C-terminal region of Neisseria meningitidis hypothetical protein NMB0372 TR:Q9K122 (EMBL:AE002393) (225 aa) fasta scores: E(): 2.7e-05, 52% id in 75 aa; hypothetical protein complement(2892212..2892961) Staphylococcus aureus subsp. aureus MRSA252 2859043 YP_042123.1 CDS SAR2789 NC_002952.2 2892980 2893783 R Poor database matches. Similar to internal regions of Bacillus subtilis minor extracellular protease precursor Epr SW:SUBE_BACSU (P16396) (645 aa) fasta scores: E(): 8.8e-17, 32.35% id in 204 aa, and Bacillus licheniformis subtilisin carlsberg precursor Apr SW:SUBT_BACLI (P00780) (379 aa) fasta scores: E(): 4e-16, 33.81% id in 207 aa; subtilase protease complement(2892980..2893783) Staphylococcus aureus subsp. aureus MRSA252 2859044 YP_042124.1 CDS cspB NC_002952.2 2894239 2894466 D Similar to Bacillus subtilis cold shock protein CspC SW:CSPC_BACSU (P39158) (66 aa) fasta scores: E(): 1.8e-17, 73.43% id in 64 aa. Previously sequenced as Staphylococcus aureus cold shock protein CspB TR:O33591 (EMBL:AF003592) (66 aa) fasta scores: E(): 6.4e-25, 100% id in 66 aa. Similar to SAR0848, 80.952% identity (80.952% ungapped) in 63 aa overlap SAR1414, 73.016% identity (73.016% ungapped) in 63 aa overlap; cold shock protein 2894239..2894466 Staphylococcus aureus subsp. aureus MRSA252 2859248 YP_042125.1 CDS SAR2791 NC_002952.2 2894593 2895162 R Similar to Streptococcus pyogenes hypothetical protein SPY1834 TR:Q99Y76 (EMBL:AE006610) (195 aa) fasta scores: E(): 2.1e-17, 37.3% id in 193 aa, and to Bacillus pumilus plasmid pSH1452 similar hypothetical protein TR:O33867 (EMBL:U53767) (211 aa) fasta scores: E(): 0.0009, 30.19% id in 202 aa; hypothetical protein complement(2894593..2895162) Staphylococcus aureus subsp. aureus MRSA252 2859045 YP_042126.1 CDS SAR2792 NC_002952.2 2895415 2895810 R Poor database matches. Similar to Bacillus halodurans hypothetical protein BH0644 TR:Q9KF42 (EMBL:AP001509) (112 aa) fasta scores: E(): 0.1, 22.44% id in 98 aa; hypothetical protein complement(2895415..2895810) Staphylococcus aureus subsp. aureus MRSA252 2859046 YP_042127.1 CDS SAR2793 NC_002952.2 2895878 2896231 R Similar to Bacillus halodurans hypothetical protein BH0644 TR:Q9KF42 (EMBL:AP001509) (112 aa) fasta scores: E(): 7.1, 22.43% id in 107 aa, and to Rhizobium loti hypothetical protein MLR8402 TR:BAB54292 (EMBL:AP003014) (109 aa) fasta scores: E(): 8.1, 26.92% id in 104 aa; hypothetical protein complement(2895878..2896231) Staphylococcus aureus subsp. aureus MRSA252 2859047 YP_042128.1 CDS SAR2795 NC_002952.2 2896726 2897565 R Similar to Bacillus halodurans DNA-binding protein Spo0J-like homologue BH4059 TR:Q9K5M9 (EMBL:AP001520) (283 aa) fasta scores: E(): 5.7e-39, 47.36% id in 285 aa, and to Bacillus subtilis hypothetical protein YyaA SW:YYAA_BACSU (P37524) (283 aa) fasta scores: E(): 6.7e-38, 48.23% id in 284 aa; DNA-binding protein complement(2896726..2897565) Staphylococcus aureus subsp. aureus MRSA252 2859048 YP_042129.1 CDS gidB NC_002952.2 2897608 2898327 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(2897608..2898327) Staphylococcus aureus subsp. aureus MRSA252 2859915 YP_042130.1 CDS gidA NC_002952.2 2898327 2900204 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA complement(2898327..2900204) Staphylococcus aureus subsp. aureus MRSA252 2859914 YP_042131.1 CDS trmE NC_002952.2 2900271 2901650 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(2900271..2901650) Staphylococcus aureus subsp. aureus MRSA252 2859049 YP_042132.1 CDS rnpA NC_002952.2 2901794 2902141 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(2901794..2902141) Staphylococcus aureus subsp. aureus MRSA252 2859277 YP_042133.1 CDS rpmH NC_002952.2 2902268 2902405 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(2902268..2902405) Staphylococcus aureus subsp. aureus MRSA252 2860165 SARt001 tRNA SARt001 NC_002952.2 24143 24217 D tRNA-Glu 24143..24217 Staphylococcus aureus subsp. aureus MRSA252 2859846 SARt002 tRNA SARt002 NC_002952.2 24225 24297 D tRNA-Asp 24225..24297 Staphylococcus aureus subsp. aureus MRSA252 2860046 SARt003 tRNA SARt003 NC_002952.2 504894 504986 D tRNA-Ser 504894..504986 Staphylococcus aureus subsp. aureus MRSA252 2861023 SARt004 tRNA SARt004 NC_002952.2 559132 559207 D tRNA-Val 559132..559207 Staphylococcus aureus subsp. aureus MRSA252 2861018 SARt005 tRNA SARt005 NC_002952.2 559224 559299 D tRNA-Thr 559224..559299 Staphylococcus aureus subsp. aureus MRSA252 2861019 SARt006 tRNA SARt006 NC_002952.2 559306 559378 D tRNA-Lys 559306..559378 Staphylococcus aureus subsp. aureus MRSA252 2860500 SARt007 tRNA SARt007 NC_002952.2 559412 559486 D tRNA-Gly 559412..559486 Staphylococcus aureus subsp. aureus MRSA252 2860501 SARt008 tRNA SARt008 NC_002952.2 559494 559582 D tRNA-Leu 559494..559582 Staphylococcus aureus subsp. aureus MRSA252 2861013 SARt009 tRNA SARt009 NC_002952.2 559588 559664 D tRNA-Arg 559588..559664 Staphylococcus aureus subsp. aureus MRSA252 2861014 SARt010 tRNA SARt010 NC_002952.2 559685 559758 D tRNA-Pro 559685..559758 Staphylococcus aureus subsp. aureus MRSA252 2860043 SARt011 tRNA SARt011 NC_002952.2 559782 559857 D tRNA-Ala 559782..559857 Staphylococcus aureus subsp. aureus MRSA252 2860044 SARt012 tRNA SARt012 NC_002952.2 561624 561700 D tRNA-Ile 561624..561700 Staphylococcus aureus subsp. aureus MRSA252 2861015 SARt013 tRNA SARt013 NC_002952.2 865895 865966 R tRNA-Arg complement(865895..865966) Staphylococcus aureus subsp. aureus MRSA252 2861020 SARt014 tRNA SARt014 NC_002952.2 1043154 1043242 R tRNA-Ser complement(1043154..1043242) Staphylococcus aureus subsp. aureus MRSA252 2861528 SARt015 tRNA SARt015 NC_002952.2 1043245 1043319 R tRNA-Asn complement(1043245..1043319) Staphylococcus aureus subsp. aureus MRSA252 2860392 SARt016 tRNA SARt016 NC_002952.2 1193918 1193991 R tRNA-Arg complement(1193918..1193991) Staphylococcus aureus subsp. aureus MRSA252 2861021 SARt017 tRNA SARt017 NC_002952.2 2000864 2000952 R tRNA-Ser complement(2000864..2000952) Staphylococcus aureus subsp. aureus MRSA252 2860555 SARt018 tRNA SARt018 NC_002952.2 2001007 2001078 R tRNA-Glu complement(2001007..2001078) Staphylococcus aureus subsp. aureus MRSA252 2860556 SARt019 tRNA SARt019 NC_002952.2 2001080 2001154 R tRNA-Asn complement(2001080..2001154) Staphylococcus aureus subsp. aureus MRSA252 2860557 SARt020 tRNA SARt020 NC_002952.2 2001169 2001242 R tRNA-Gly complement(2001169..2001242) Staphylococcus aureus subsp. aureus MRSA252 2860558 SARt021 tRNA SARt021 NC_002952.2 2001258 2001333 R tRNA-His complement(2001258..2001333) Staphylococcus aureus subsp. aureus MRSA252 2860559 SARt022 tRNA SARt022 NC_002952.2 2001347 2001419 R tRNA-Phe complement(2001347..2001419) Staphylococcus aureus subsp. aureus MRSA252 2860047 SARt023 tRNA SARt023 NC_002952.2 2001436 2001511 R tRNA-Asp complement(2001436..2001511) Staphylococcus aureus subsp. aureus MRSA252 2860048 SARt024 tRNA SARt024 NC_002952.2 2001533 2001606 R tRNA-Met complement(2001533..2001606) Staphylococcus aureus subsp. aureus MRSA252 2860049 SARt025 tRNA SARt025 NC_002952.2 2033867 2033950 R tRNA-Leu complement(2033867..2033950) Staphylococcus aureus subsp. aureus MRSA252 2859800 SARt026 tRNA SARt026 NC_002952.2 2033989 2034063 R tRNA-OTHER complement(2033989..2034063) Staphylococcus aureus subsp. aureus MRSA252 2859703 SARt027 tRNA SARt027 NC_002952.2 2034079 2034153 R tRNA-Gly complement(2034079..2034153) Staphylococcus aureus subsp. aureus MRSA252 2859704 SARt028 tRNA SARt028 NC_002952.2 2034161 2034234 R tRNA-Cys complement(2034161..2034234) Staphylococcus aureus subsp. aureus MRSA252 2859705 SARt029 tRNA SARt029 NC_002952.2 2034240 2034311 R tRNA-Gln complement(2034240..2034311) Staphylococcus aureus subsp. aureus MRSA252 2859706 SARt030 tRNA SARt030 NC_002952.2 2034323 2034395 R tRNA-His complement(2034323..2034395) Staphylococcus aureus subsp. aureus MRSA252 2859707 SARt031 tRNA SARt031 NC_002952.2 2034398 2034471 R tRNA-Trp complement(2034398..2034471) Staphylococcus aureus subsp. aureus MRSA252 2859708 SARt032 tRNA SARt032 NC_002952.2 2034487 2034567 R tRNA-Tyr complement(2034487..2034567) Staphylococcus aureus subsp. aureus MRSA252 2859709 SARt033 tRNA SARt033 NC_002952.2 2034573 2034648 R tRNA-Thr complement(2034573..2034648) Staphylococcus aureus subsp. aureus MRSA252 2861724 SARt034 tRNA SARt034 NC_002952.2 2034656 2034728 R tRNA-Phe complement(2034656..2034728) Staphylococcus aureus subsp. aureus MRSA252 2861725 SARt035 tRNA SARt035 NC_002952.2 2034747 2034822 R tRNA-Asp complement(2034747..2034822) Staphylococcus aureus subsp. aureus MRSA252 2861726 SARt036 tRNA SARt036 NC_002952.2 2034832 2034905 R tRNA-Met complement(2034832..2034905) Staphylococcus aureus subsp. aureus MRSA252 2861727 SARt037 tRNA SARt037 NC_002952.2 2034920 2035012 R tRNA-Ser complement(2034920..2035012) Staphylococcus aureus subsp. aureus MRSA252 2861728 SARt038 tRNA SARt038 NC_002952.2 2035051 2035126 R tRNA-Asp complement(2035051..2035126) Staphylococcus aureus subsp. aureus MRSA252 2861729 SARt039 tRNA SARt039 NC_002952.2 2035137 2035226 R tRNA-Ser complement(2035137..2035226) Staphylococcus aureus subsp. aureus MRSA252 2861730 SARt040 tRNA SARt040 NC_002952.2 2035236 2035309 R tRNA-Met complement(2035236..2035309) Staphylococcus aureus subsp. aureus MRSA252 2861731 SARt041 tRNA SARt041 NC_002952.2 2035335 2035411 R tRNA-Met complement(2035335..2035411) Staphylococcus aureus subsp. aureus MRSA252 2861175 SARt042 tRNA SARt042 NC_002952.2 2035433 2035508 R tRNA-Ala complement(2035433..2035508) Staphylococcus aureus subsp. aureus MRSA252 2861176 SARt043 tRNA SARt043 NC_002952.2 2035526 2035599 R tRNA-Pro complement(2035526..2035599) Staphylococcus aureus subsp. aureus MRSA252 2861177 SARt044 tRNA SARt044 NC_002952.2 2035609 2035682 R tRNA-Arg complement(2035609..2035682) Staphylococcus aureus subsp. aureus MRSA252 2861178 SARt045 tRNA SARt045 NC_002952.2 2035701 2035789 R tRNA-Leu complement(2035701..2035789) Staphylococcus aureus subsp. aureus MRSA252 2861179 SARt046 tRNA SARt046 NC_002952.2 2035800 2035874 R tRNA-Gly complement(2035800..2035874) Staphylococcus aureus subsp. aureus MRSA252 2861180 SARt047 tRNA SARt047 NC_002952.2 2035878 2035959 R tRNA-Leu complement(2035878..2035959) Staphylococcus aureus subsp. aureus MRSA252 2861181 SARt048 tRNA SARt048 NC_002952.2 2035963 2036038 R tRNA-Lys complement(2035963..2036038) Staphylococcus aureus subsp. aureus MRSA252 2861131 SARt049 tRNA SARt049 NC_002952.2 2036044 2036119 R tRNA-Thr complement(2036044..2036119) Staphylococcus aureus subsp. aureus MRSA252 2861132 SARt050 tRNA SARt050 NC_002952.2 2036136 2036211 R tRNA-Val complement(2036136..2036211) Staphylococcus aureus subsp. aureus MRSA252 2861133 SARt051 tRNA SARt051 NC_002952.2 2039546 2039621 R tRNA-Ala complement(2039546..2039621) Staphylococcus aureus subsp. aureus MRSA252 2861136 SARt052 tRNA SARt052 NC_002952.2 2039640 2039716 R tRNA-Ile complement(2039640..2039716) Staphylococcus aureus subsp. aureus MRSA252 2861137 SARt053 tRNA SARt053 NC_002952.2 2218924 2218997 R tRNA-Gly complement(2218924..2218997) Staphylococcus aureus subsp. aureus MRSA252 2860041 SARt054 tRNA SARt054 NC_002952.2 2219016 2219101 R tRNA-Leu complement(2219016..2219101) Staphylococcus aureus subsp. aureus MRSA252 2860042 SARt055 tRNA SARt055 NC_002952.2 2331669 2331744 R tRNA-Lys complement(2331669..2331744) Staphylococcus aureus subsp. aureus MRSA252 2860697 SARt056 tRNA SARt056 NC_002952.2 2331748 2331822 R tRNA-Gln complement(2331748..2331822) Staphylococcus aureus subsp. aureus MRSA252 2860698 SARt057 tRNA SARt057 NC_002952.2 2331832 2331915 R tRNA-Tyr complement(2331832..2331915) Staphylococcus aureus subsp. aureus MRSA252 2861289 SARt058 tRNA SARt058 NC_002952.2 2331944 2332019 R tRNA-Val complement(2331944..2332019) Staphylococcus aureus subsp. aureus MRSA252 2861290 SARt059 tRNA SARt059 NC_002952.2 2332027 2332098 R tRNA-Glu complement(2332027..2332098) Staphylococcus aureus subsp. aureus MRSA252 2861291 SARt060 tRNA SARt060 NC_002952.2 2332100 2332174 R tRNA-Asn complement(2332100..2332174) Staphylococcus aureus subsp. aureus MRSA252 2861292 SARr001 rRNA SARr001 NC_002952.2 514251 515805 D 16S ribosomal RNA 514251..515805 Staphylococcus aureus subsp. aureus MRSA252 2860128 SARr002 rRNA SARr002 NC_002952.2 516229 519151 D 23S ribosomal RNA 516229..519151 Staphylococcus aureus subsp. aureus MRSA252 2860129 SARr003 rRNA SARr003 NC_002952.2 519224 519338 D 5S ribosomal RNA 519224..519338 Staphylococcus aureus subsp. aureus MRSA252 2860130 SARr004 rRNA SARr004 NC_002952.2 559005 559119 D 5S ribosomal RNA 559005..559119 Staphylococcus aureus subsp. aureus MRSA252 2861017 SARr005 rRNA SARr005 NC_002952.2 559978 561532 D 16S ribosomal RNA 559978..561532 Staphylococcus aureus subsp. aureus MRSA252 2860045 SARr006 rRNA SARr006 NC_002952.2 561991 564913 D 23S ribosomal RNA 561991..564913 Staphylococcus aureus subsp. aureus MRSA252 2861016 SARr007 rRNA SARr007 NC_002952.2 564986 565100 D 5S ribosomal RNA 564986..565100 Staphylococcus aureus subsp. aureus MRSA252 2859702 SARr008 rRNA SARr008 NC_002952.2 2036223 2036337 R 5S ribosomal RNA complement(2036223..2036337) Staphylococcus aureus subsp. aureus MRSA252 2861134 SARr009 rRNA SARr009 NC_002952.2 2036410 2039332 R 23S ribosomal RNA complement(2036410..2039332) Staphylococcus aureus subsp. aureus MRSA252 2861135 SARr010 rRNA SARr010 NC_002952.2 2039806 2041361 R 16S ribosomal RNA complement(2039806..2041361) Staphylococcus aureus subsp. aureus MRSA252 2861138 SARr011 rRNA SARr011 NC_002952.2 2213775 2213889 R 5S ribosomal RNA complement(2213775..2213889) Staphylococcus aureus subsp. aureus MRSA252 2860038 SARr012 rRNA SARr012 NC_002952.2 2213963 2216887 R 23S ribosomal RNA complement(2213963..2216887) Staphylococcus aureus subsp. aureus MRSA252 2860039 SARr013 rRNA SARr013 NC_002952.2 2217252 2218806 R 16S ribosomal RNA complement(2217252..2218806) Staphylococcus aureus subsp. aureus MRSA252 2860040 SARr014 rRNA SARr014 NC_002952.2 2332186 2332300 R 5S ribosomal RNA complement(2332186..2332300) Staphylococcus aureus subsp. aureus MRSA252 2861293 SARr015 rRNA SARr015 NC_002952.2 2332374 2335296 R 23S ribosomal RNA complement(2332374..2335296) Staphylococcus aureus subsp. aureus MRSA252 2861294 SARr016 rRNA SARr016 NC_002952.2 2335736 2337289 R 16S ribosomal RNA complement(2335736..2337289) Staphylococcus aureus subsp. aureus MRSA252 2861295